# Patent

## Title
Fluorescence energy transfer and intramolecular energy transfer in

## Abstract

This is a divisional of application Ser. No. 08/362,577, filed as PCT/JP93/00936 Jul. 7, 1993.

## Background
The present invention relates to probes, prepared by making use of causative bacteria of infectious diseases, which are useful for detecting and identifying the causative bacteria.

In pathology, infection is defined as invasion and establishment of a foothold for growth in an organism by a pathogenic organism (hereinafter referred to as "bacteria"), then the outbreak of disease depends upon the interrelationship between the resistance of host and the virulence of bacteria.

In the infectious diseases, improvement in treatment methods of bateremia have been raised as an important issue. That is to say, bacteremia is not a disease caused by a particular bacterium, but is caused by emergence and habitancy of the various bacteria in blood, then onset thereof is clinically suspected when fever of about 40.degree. C. persists for two or more days. If a patient is an infant or is suffering from terminal cancer with weakened resistance, the patient may die in one or two days, therefore, the bacteremia is a serious and urgent disease, and the improvement in treatment methods thereof have been awaited.

In the infectious disease, phagocytes including neutrophils, monocytes and macrophages primarily work in defense of the body. Emergence of bacteria in the blood is thought as invasion of predominant bacteria which have emerged from the tissue of the phagocyte.

Bacteremia is a state wherein the bacteria is emerged into the blood, and a large amount of antibiotic is administrated to treat it wherein the causative bacteria is sensitive to the antibiotic. Generally, since antibiotics lower the functions of the internal organs such as liver, it is necessary to pay an attention to reduce an administration of an ineffective antibiotic to a patient in a serious state.

When bacteremia is defined as a case wherein phagocytesis of cells can not overcome the virulence of bacteria, then the bacteria spread in the body through the blood, bacteremia with serious symptoms due to toxins produced by the bacteria is called as sepsis. Proof of sepsis, in the other word, establishment of the diagnosis requires a check on the items of 1) clinical symptoms, 2) culturing of specimen, 3) gram-staining of the bacteria contained in the specimen, and 4) shock state, then, upon completing the check of these items, the treatment method is determined. Accordingly, to quickly and reliably identify the bacteria have been awaited in the art.

In the present method for detecting and identifying bacteria in a bacteremia-specimen, it is a common procedure to identify in selective medium a specimen which have positive signal in a routine process of culture bottle. However, to successfuly culture the bacteria from these blood specimen is quite difficult, then, if a large dose of antibiotics is administrated when bacteremia was suspected, bacteria in the blood will not be cultured and grown in many cases, therefore, the rate of culture bottle positive case become extremely low.

Although available sub-routine methods include instrumental analysis of constituents and metabolic products of bacteria (Yoshimi Benno, "Quick identification of bacteria with gas chromatography", Rinsho Kensa, Vol. 29, No. 12, November 1985, lgaku Shoin ed.), a method utilizing specific antibody (Japanese Patent Provisional Publication No. 60-224068), and a hybridization method utilizing specificity of DNA (Japanese Phase Patent Provisional Publication No. 61-502376) have been developed, any of which are required to separate the bacteria and culture it. On the other hand, as a method established based on the function of phagocytes in infectious diseases, there is a method to examine, under an optical microscope, a stained smear of buffy coat wherein leukocyte of the blood sample is concentrated. Generally speaking, although the rate of detection of bacteria in buffy coat specimens from adult bacteremia patients is 30% at most, which is similar to that in earlobe blood specimens, it was reported that bacteria had been detected in seven cases of ten cases (70%) in newborn patients, therefore, an information concerning the presence of a bacteria in peripheral blood to be obtained by microscope examination on smear is an important for treatment.

Since the conventional methods necessiate the pretreatment which requires at least three to four days in total containing one to two day(s) for selective isolation of bacteria from a specimen, one day for cultivation, and one or more day(s) for fixation, and the culture thereof is continued in practice until the bacteria grow, the culture will needs one week or more even for C.B.-positive cases, therefore, this was a factor in high mortality of C.B.-positive patients being treated by the conventional methods. For example, according to the a report published in "The Journal of the Japanese Association for Infectious Diseases", Vol. 58, No. 2, p. 122, 1984, even though the blood culture positive rate was 28.6% (163 cases/569 cases), the mortality was as high as 84.6% (138 cases/163 cases).

Further, it may be impossible to distinguish contamination at the cultivation by indigenous bacteria. For example, Staphylococcus epidermides, which is one of Staphylococci and is the causative bacterium of bacteremia, stayed in the skin of the normal person, then, there is a risk on contamination of a specimen with this bacterium when a needle is inserted into the skin.

As an important matter, under such circumstances above, since many bacteria in a specimen to be cultured have been incorporated into said phagocyte and are dead or stationary immobilized, the number of growable bacteria is small even under appropriate conditions for cultivation, thereby, the actual detection rate of bacteria through culture specimen is as low as about 10%. In the other word, at this moment, 90% of the examined blood, which have been cultured for further one or more day(s), of the patient suspected clinically as suffering with bacteremia can not clarify the presence of bacteria.

In light of the situation above, the present practice depends on a treatment to be started when bacteremia is clinically suspected without awaiting the detection results, that is to say, a trial and error method wherein an antibiotic having broad spectrum is administrated first, and if the antibiotic is not effective after one or two day(s), another antibiotic will be tried.

According to the method to stain the bacteria in the specimen, the constituents of the living body are also stained together with bacteria, therefore, experience to quickly identify bacteria according to thier image through microscope is required, then there may be cases that can be hardly diagnosed as bacteremia.

Although bacteremia is a disease wherein a rapid and exact diagnosis have been required, the conventional diagnosis method can not respond to such requirements.

The present invention was established in view of the problems in the art, and is directed to a probe having a specific reactivity with DNA or RNA obtained from primary causative bacteria of the infectious diseases, then provide a genetic information by analyzing the base sequence of DNA in the probe.

By the probe of the present invention, for example, a causative bacteria of the infectious diseases is detected rapidly and exactly, without cultivating/proliferating the bacteria, through a detection of DNA held in the causative bacteria digested and incorporated gradually with the phagocyte. Then, if primers are designed by referring to an information on base sequence of these probes, causative bacteria can identify, without the hybridization, by amplifying the DNA with PCR technique.

When non-radioactive probe, for example, biotinylated probe is used for hybridization, since such probe can be detected with an optical microscope in a conventional laboratory without radio isotope handling facilities, the detection process would be rapid and simple.

FIG. 1 is a restriction enzyme map of HindIII fragment on probe for detecting Staphylococcus aureus.

FIG. 2 is a restriction enzyme map of Hindlll fragment on probe for detecting Staphylococcus epidermidis.

FIG. 3 is a restriction enzyme map of HindIII fragment on probe for detecting Enterococcus faecalis.

FIG. 4 is a restriction enzyme map of HindIII fragment on probe for detecting Pseudomonas aeruginosa.

FIG. 5 is a restriction enzyme map of HindIII fragment on probe for detecting Escherichia coli.

FIG. 6 is a restriction enzyme map of HindIII fragment on probe for detecting Enterobacter cloacae and Klebsiella pneumonia.

Examples on probes prepared from Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae (J. Infection, vol. 26, pp. 159-170 (1993), J. Clin. Microbiol., vol. 31., pp. 552-557 (1993)) respectively listed as relatively popular causative bacteria of the infectious diseases, especially bacteremia were described as follows.

Preparation of DNA Probe from Causative Bacteria of Infectious Diseases

(1) Isolation of Causative Bacteria of Infectious Diseases

Blood collected from the patient who have been suffered with targeted diseases were applied to Blood Culture Method (BBC System: Blood Culture System; Roche) and to a conventional identification kit (Api 20, Apistaf, Apistlep 20: Bio-Meryu), and the each causative bacterium was isolated and identified according to the manual of said kit.

(2) Extraction and Purification of Genomic DNA from Isolated Strain

Strains isolated in the above (1) was cultivated overnight in BHI (Brain Heart Infusion) medium, collected the cultivated bacteria, added thereto achromopeptidase in stead of lysozyme, then, Genomic DNA was extracted according to Saito-Miura Method ("Preparation of Transforming Deoxyribonucleic Acid by Phenol Treatment", Biochem. Biophys. Acta. vol. 72, pp. 619-629), and extracted DNA was digested with restriction enzyme HindIII and was random cloned into vector pBR322.

(3) Selection of Probe having Specificity to Species of Origin Bacteria Escherichia coli containing each clone prepared according to Manual of Maniatis (T. Maniatis, et al., "Molecular Cloning (A Laboratory Manual)", Cold Spring Harbour Laboratory (1982)) was cultivated with small scale culture, and obtained plasmids containing each clone.

These plasmids were digested with restriction enzyme HindIII, thereby inserts were separated completely from plasmids with 1% agarose-gel electrophoresis (Myupid: Cosmo-Bio), then, were transcribed to nylon membrane with Southern-Transfer Technique (Paul Biodine A: Paul), and were cross-hybridized with a probe prepared by labelling .sup.32 P-dCTP (Amersham) through nick-translation to chromosome DNA from each bacteria species aforelisted.

In this hybridization, a probe which did not cross-react with any insert except for a probe prepared from the origin species thereof was selected as a probe containing DNA fragment which is specific to causative bacteria of the infectious diseases.

With regard to probes prepared from Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, since these bacteria are belonged to the same group (enteric bacteria; Gram negative aerobic bacillus) as a causative bacteria of bacteremia (See, J. Infection, vol. 26, pp. 159-170 (1993), J. Clin. Microbiol., vol. 31., pp. 552-557 (1993), supra), and the cross-reaction had been confirmed among said three bacteria in the foregoing series experiments on the specificity, each probe prepared from one of said three bacteria was designated as a probe for detecting all these bacteria as a relevant bacteria.

Probes (denotation) selected from each species through the foregoing methods are listed in the following Table 1. ______________________________________ SPECIES          DENOTATION ______________________________________ Staphylococcus aureus SA-7, SA-24, SA-36, SA-77 Staphylococcus epidermidis SE-3, SE-22, SE-32, SE-37 Enterococcus faecalis S2-1, S2-3, S2-7, S2-27 Pseudomonas aeruginosa P2-2, P2-7, P2-17, P4-5 Escherichia coli EC-24, EC-34, EC-39, EC-625 Klebsiella pneumoniae KI-50 Enterobacter cloacae ET-12, ET-49 ______________________________________

Restriction enzyme maps of each probe were also illustrated in FIGS. 1-6 respectively.

Evaluation on Species-Specificity of Each DNA Probe

Reactivity between each probe and DNA from causative bacteria of infectious diseases were examined acooding to the following method.

First of all, as subject strains for an examination, clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae were isolated according to the method of Example 1 (1) above.

Then, DNA of each clinical isolate were extracted according to the method of Example 1 (2), and samples for dot-blot-hybridization were obtained by spotting certain amount (e.g., 5 .mu.l) of DNA to nylon filter and selecting the isolates denatured with alkaline. Hybridization on DNA probes prepared from each subjected bacterium and labelled with biotin (Bio-dUTP; BRL) were performed overnight according to Manual of Maniatis, supra, under the condition of 45% formamide, 5.times.SSC, 42.degree. C.

Samples obtained through overnight hybridization were washed twice with 0.1.times.SSC, 0.1% SDS for 20 minutes at 55.degree. C., then, were detected the color reaction with Streptavidin-ALP conjugates (BRL), and evaluated the hybridization.

Experimental results on reactivity between each probe and DNA of each clinical isolate are illustrated in the following table 2 (i)-(vi). With regard to a denotation in the tables, denotation of "+" refers to the presence of a signal on hybridization, while that of "-" refers to the absence of a signal on hybridization. ______________________________________ SA-7  SA-24    SA-36    SA-77 ______________________________________ Staphylococcus aureus +       +        +      + Staphylococcus epidermidis -       -        -      - Enterococcus faecalis -       -        -      - Pseudomonas aeruginosa -       -        -      - Escherichia coli -       -        -      - Klebsiella pneumoniae -       -        -      - Enterobacter cloacae -       -        -      - ______________________________________ ______________________________________ SE-3  SE-22    SE-32    SE-37 ______________________________________ Staphylococcus aureus -       -        -      - Staphylococcus epidermidis +       +        +      + Enterococcus faecalis -       -        -      - Pseudomonas aeruginosa -       -        -      - Escherichia coli -       -        -      - Klebsiella pneumoniae -       -        -      - Enterobacter cloacae -       -        -      - ______________________________________ ______________________________________ S2-1 S2-3     S2-7   S2-27 ______________________________________ Staphylococcus aureus -      -        -    - Staphylococcus epidermidis -      -        -    - Enterococcus faecalis +      +        +    + Pseudomonas aeruginosa -      -        -    - Escherichia coli -      -        -    - Klebsiella pneumoniae -      -        -    - Enterobacter cloacae -      -        -    - ______________________________________ ______________________________________ P2-2 P2-7     P2-17  P4-5 ______________________________________ Staphylococcus aureus -      -        -    - Staphylococcus epidermidis -      -        -    - Enterococcus faecalis -      -        -    - Pseudomonas aeruginosa +      +        +    + Escherichia coli -      -        -    - Klebsiella pneumoniae -      -        -    - Enterobacter cloacae -      -        -    - ______________________________________ ______________________________________ EC-24  EC-34    EC-39    EC-625 ______________________________________ Staphylococcus aureus -        -        -      - Staphylococcus epidermidis -        -        -      - Enterococcus faecalis -        -        -      - Pseudomonas aeruginosa -        -        -      - Escherichia coli +        +        +      + Klebsiella pneumoniae +        +        +      + Enterobacter cloacae +        +        +      + ______________________________________ ______________________________________ ET-12    ET-49   KI-50 ______________________________________ Staphylococcus aureus -          -       - Staphylococcus epidermidis -          -       - Enterococcus faecalis -          -       - Pseudomonas aeruginosa -          -       - Escherichia coli +          +       + Klebsiella pneumoniae +          +       + Enterobacter cloacae +          +       + ______________________________________

Apparently from Table 2 above, each probe have reacted only with DNA obtained from origin strain (or relative strain thereof) and not reacted (hybridized) with any DNA obtained from strains except for strains from the origin strain, therefore, their specificity have been confirmed.

Analysis of Base Sequence

Base sequence of DNA probes (total 23 probes) of the present invention, which have been confirmed their specificity to the origin species in the Examples 1 and 2, were sequenced according to the following method.

(1) Preparation of Plasmid DNA

Escherichia coli K-12, JM109 transformants, wherein the subcloned insert fragments (to be seqeuenced) is contained in pGem-3Z (Promega), was inoculated in 5 ml of Luria-Bactani Medium (bacto-tryptone, 10 g/1 L; bacto-yeast extract, 5 g/1 L; NaCl, 10 g/1 L; adjusted pH to 7.0 with 5N NaOH) and cultivated overnight.

Culture liquid was centrifuged (5,000 rpm, 5 min.) and collected the bacteria. 100 .mu.l of solution of 50 mM glucose/50 mM Tris-HCl (pH8.0)10 mM EDTA containing 2.5 mg/ml of lysozyme (Sigma) was added to precipitate, and left at room temperature for five minutes. 0.2M NaOH solution containing 1% of sodium dodecyl sulfate (Sigma) was added to the suspension so obtained and mixed therewith. 150 .mu.l of 5M pottasium acetate solution (pH 4.8) was further added thereto and mixed therewith, then iced for 15 minutes.

Supernatant obtained by centrifugation (15,000 rpm, 15 min.) was treated with phenol/CHCI.sub.3 and added thereto ethanol of two times volume, then precipitate was obtained by centrifugation (12,000 rpm, 5 min.). This precipitate was dissolved in 100 .mu.l of solution of 10 mM Tris-HCl (pH7.5)/0.1 mM EDTA and added thereto 10 mg/ml RNaseA (Sigma) solution, then left it at room temperature for 15 minutes.

300 .mu.l of 0.1M sodium acetate solution (pH 4.8) was added to this preparation and treated with phenol/CHCI.sub.3, then precipitate was obtained by adding ethanol to supernatant. DNA samples were prepared by drying this precipitate and dissolving in 10 .mu.l distilled water.

(2) Pretreatment for Sequencing

Pretreatment for sequencing was performed with AutoRead.TM. Sequencing Kit (Pharmasia).

Concentration of DNA to become a template was adjusted to 5-10 .mu.g in 32 .mu.l. 32 .mu.l of template DNA was transferred to 1.5 ml mini-tube (Eppendolf), and added thereto 8 .mu.l of 2M NaOH solution, then mixed gently therewith. After instant centrifugation, it was left at room temperature for 10 minutes.

7 .mu.l of 3M sodium acetate (pH 4.8) and 4 .mu.l a of distilled water, then 120 .mu.l a of ethanol were added thereto then mixed therewith, and left for 15 minutes on dry ice. DNA which have been precipitated by centrifugation for 15 minutes were collected, and supernatant was removed carefully. The precipitate so obtained were washed with 70% ethanol and centrifuged for 10 minutes. Then, the supernatant was removed carefully again and dried the precipitate under the reduced pressure.

The precipitate was dissolved in 10 .mu.l of distilled water, then 2 .mu.l of fluorescent primer (0.42 A.sub.260 unit/10 ml, 4-6 pmol) (M13 Universal Primer; 5'-Fluorescein-dCGACGTTGTAAAACGACGGCCAGT!-3' (SEQ ID NO:24) (1.6 pmol/.mu.l; 0.42 A.sub.260 unit/ml); M13 Reverse Primer, 5'-Fluorescein-dCAGGAAACAG CTATGAC!-3' (SEQ ID NO:25) (2.1 pmol/.mu.l; 0.42 A.sub.260 unit/ml! and 2 .mu.l of saline for annealing were added thereto, and mixed gently.

After instant centrifugation, they were heat-treated at 65.degree. C. for 5 minutes and rapidly transferred it to a circumstance of 37.degree. C. and kept the temperature for 10 minutes. After keeping the temperature, it was left at room temperature for 10 minutes or more and centrifugated instantly. Then, samples were prepared by adding thereto 1 .mu.l of an elongation saline and 3 .mu.l of dimethyl sulfoxide.

Four mini-tubes have been identified with one of marks of "A", "C", "G" and "T", and, according to the mark, 2.5 .mu.l of A Mix (dissolved ddATP with dATP, dCTP, c.sup.7 dGTP and dTTP), C Mix (dissolved ddCTP with dATP, dCTP, c.sup.7 dGTP and dTTP), G Mix (dissolved ddGTP with dATP, dCTP, c.sup.7 dGTP and dTTP), or T Mix (dissolved ddTTP with dATP, dCTP, c.sup.7 dGTP and dTTF) were poured into each identified tube. Each solution was preserved in freezed condition, and the solution was heated at 37.degree. C. for one minute or more to use it.

2 .mu.l of diluted T7DNA polymerase (Pharmacia; 6-8 units/2 .mu.l ) was added to DNA sample, and completely mixed by pipetting or mixing it gently. Immediately after completing the mixing, these mixed solution was poured into 4.5 .mu.l of four-types solution respectively which have kept the certain temperature. Fresh tips were used at the time of pouring.

The solution have been kept for five minutes at 37.degree. C., then 5 .mu.l of termination solution were poured into each reaction-solution. Fresh tips were used for pouring. Immediately after keeping the solution for 2-3 minutes at 90.degree. C., it was cooled on ice. 4-6 .mu.l/lane of the solution was applied to the electrophoresis.

(3) Sequencing on Base Sequence

Sequencing on each base sequence of probes, disclosed in Examples 1 and 2, having the specificity against Staphylococcus aureus or Staphylococcus epidermidis were performed with A.L.F. DNA Sequencer System (Pharmacia) under an electrophoresis condition of 45.degree. C. for 6 hours.

Then, base sequences of the probes (SEQ ID.No.) prepared from each causative bacteria of the infectious diseases and listed in the following table 3 were disclosed in the sequence listing attached hereto. ______________________________________ SPECIES            Probes (SEQ ID. No.) ______________________________________ Staphylococcus aureus SA-7 (1), SA-24 (2) SA-36 (3), SA-77 (4) Staphylococcus epidermidis SE-3 (5), SE-22 (6) SE-32 (7), SE-37 (8) Enterococcus faecalis S2-1 (9), S2-3 (10) S2-7 (11), S2-27 (12) Pseudomonas aeruginosa P2-2 (13), S2-7 (14) P2-17 (15), P4-5 (16) Escherichia coli   EC-24 (17), EC-34 (18), EC-39 (19), EC-625 (20) Klebsiella pneumoniae KI-50 (23) Enterobacter cloacae ET-12 (21), ET-49 (22) ______________________________________

Thereby, genetic information concerning the specific site of each causative bacteria of the infectious diseases (or relative bacteria thereof) have been clarified.

According to probes of the present invention, for example, causative bacteria of the infectious diseases which have incorporated into the phagocyte can be directly detected, and rapidly and exactly identified without proliferating the bacteria. That is to say, according to the diagnosis using the probe of the present invention, identification of the bacteria can be realized with single specimen, then, reduced the necessary time for diagnosis to about one to two day(s), while the conventional method (with low detection rate) required 3-4 days, and improved remarkably the detection rate. Therefore, this invention can provide an objective factors for the treatment of bacteremia, then realize the effective treatment in the early stage of the infectious diseases, and expect to reduce the mortality.

Then, by clarifying the base sequences of probes which specifically react with primary bacteria of the infectious diseases, these probes can be prepared artifically. Further, a part of information on the analyzed base sequences may be used for rapidly diagnosing the causative bacteria by amplifying DNA of causative bacteria of the infectious diseases in the clinical specimen with PCR technique and primers prepared by making use of said information.

Further, by comparing base sequences of Genomic DNA in the clinical specimen with that of the present invention, rapid identification of the species of the causative bacteria of infectious diseases can be realized.

As stated above, the present invention provide desirable probes for diagnosing the infectious diseases, then expect utilities as a factor to prepare primers for PCR and standard sequence for a comparison with Genomic DNA in the clinical specimen, and further expect an effect to provide valuable hints for preparing and developing the other probes which specifically react with causative bacteria of the infectious diseases.

Then, since the base sequences disclosed in the present application was obtained by random-cloning the Genomic DNA of clinical isolates, utilities of the base sequences of the present invention should be extended to the complementary strands thereof.

Further, although it may be thought that DNA obtained from the wild strains contain the mutated portion, apparently from the disclosure of the Examples above, said mutated DNA portion would not affects the utilities to be derived by the present invention comprising the specificity of the probes of the present invention in the hybridization for a diagnosis of the infectious diseases, and an usage of the information on the base sequences disclosed in the present application to design the primers for PCR technique to realize a rapid diagnosis of the infectious diseases. SEQUENCE LISTING (1) GENERAL INFORMATION: (iii) NUMBER OF SEQUENCES: 25 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8959 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus aureus (B) STRAIN: Clinical Isolate SA- 7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: AAGCTTTATCTGCTGAATATACCGCATTTTTTATCTTGTTAATTGTCGGCACATTTTCTT60 CAATAGTTAAACCTGCTTTGTTAGCTTCTTCTAATAATGCTCGAGTTACTGTTTATTAAA120 TGTTCATTCGCTTTTCAACGACAACTGACGAACCAGTATCTGTTAGCTTAGACGCAACAG180 CGTTAATCTTCTGATTCACCTTAAATTCTACATCTGCTTTTTGAGGCTGCTTACGTAGTG240 TCCCGGTAATTTCATGTGTAAACTTAGATGGGATGTAAATACCTGCAAAATATTTACCCA300 TTTTTATCTCATGATCAGCTTTCTCTCTACTTACAAACTGCCAATCAAAACTTTTATTTT360 TCTTGAGTGTATTAACCATCGTATTACCGACATTAACTTTTTTCCCTCTGATTGTGTCGC420 CTTTATCTTCATTAACGACTGCGACCTTGATGTGTCCCGTGTTGCCATATGGATCCCACA480 TTGCCCATAAGTTAAACCAAGCGTAGAACGATGGCAAAATAGCTAAGCCTGCTAAGATAA540 TCCACACAGCTGGCGTCTTAGCTACTTTCTTCAGATCCATTTTAAATAATTTAAATGCGT600 TCTTCATTGTCACACTCCTATGTAGGAATTATTCATATTTTTTATATATTTTTTGTAAAT660 TAATTTATTTTTGCGTTGTGAATTAGTATAATCAATTTACTGGAAGATATTTAGTCGATT720 GATACCTATCAACTATTTTCAGCATACGATAAATTATAACAAATCATAGTTTATTATCAC780 ACTTAATTATTATATTTTTCAAGGGAGAATACGAAATATGCCTAAAAATAAAATTTTAAT840 TTATTTGCTATCAACTACCCTCGTATTACCTACTTTAGTTTCACCTACCGCTTATGCTGA900 TACACCTCAAAAAGATACTACAGCTAAGACAACATCTCATGATTCAAAAAAATCTAATGA960 CGATGAAACTTCTAAGGATACTACAAGTAAAGATACTGATAAAGCAGACAACAATAATAC1020 AAGTAACCAAGACAATAACGACAAAAAATTTAAAACTATAGACGACAGCACTTCAGACTC1080 TAACAATATCATTGATTTTATTTATAAAGAATTTACCACAAACCAATATAAACCAATTGC1140 TAACCAAAAATAAATACGATGATAATTACTCATTAACAACTTTAATCCAAAACTTATTCA1200 ATTTAAATTCGGATATTTCTGATTACGAACAACCTCGTAATGGCGAAAAGTCAACAAATG1260 ATTCGATAAAAACAGTGACATAGCATCAAAAATGACACTGATACGCAATCATCTAAACAA1320 GATAAAGCAGACAATCAAAAAGCACCTAAATCAAACAATACAAAACCAAGTACATCTAAT1380 AAGCAACCAAATTCGCCAAAGCCAACACAACCTAATCAATCAAATAGTCAACCAGCAAGT1440 GACGATAAAGCAAATCAAAAATCTTCATCGAAAGATAATCAATCAATGTCAGATTCGGCT1500 TTAGACTCTATTTTGGATCAATACAGTGAAGATGCAAAGAAAACACAAAAAGATTATGCA1560 TCTCAATCTAAAAAAGACAAAAATGAAAAATCTAATACAAAGAATCCACAGTTACCAACA1620 CAAGATGAATTGAAACATAAATCTAAACCTGCTCAATCATTCAATAACGATGTTAATCAA1680 AAGGATACACGTGCAACATCATTATTCGAAACAGATCCTAGTATATCTAACAATGATGAT1740 AGCGGACAATTTAACGTTGTTGACTCAAAAGATACACGTCAATTTGTCAAATCAATTGCT1800 AAAGATGCACATCGCATTGGTCAAGATAACGATATTTATGCGTCTGTCATGATTGCCCAA1860 GCAATCTTAGAATCTGACTCAGGTCGTAGTGCTTTAGCTAAGTCACCAAACCATAATTTA1920 TTCGGTATCAAAGGTGCTTTTGAAGGGAATTCTGTTCCTTTTAACACATTAGAAGCTGAT1980 GGTAATAAATTGTATAGTATTAATGCTGGATTCCGAAAATATCCAAGCACGAAAGAATCA2040 CTAAAAGATTACTCTGACCTTATTAAAAATGGTATTGATGGCAATCGAACAATTTATAAA2100 CCAACATGGAAATCGGAAGCCGATTCTTATAAAGATGCAACATCACACTTATCTAAAACA2160 TATGCTACAGATCCAAACTATGCTAAGAAATTAAACAGTATTATTAAACACTATCAATTA2220 ACTCAGTTTGACGATGAACGCATGCCAGATTTAGATAAATATGAACGTTCTATCAAGGAT2280 TATGATGATTCATCAGATGAATTCTGTTCCTTTTAACACATTAGAAGCTGATGGTAATAA2340 ATTGTATAGTATTAATGCTGGATTCCGAAAATATCCAAGCACGAAAGAATCACTAAAAGA2400 TTACTCTGACCTTATTAAAAATGGTATTGATGGCAATCGAACAATTTATAAACCAACATG2460 GAAATCGGAAGCCGATTCTTATAAAGATGCAACATCACACTTATCTAAAACATATGCTAC2520 AGATCCAAACTATGCTAAGAAATTAAACAGTATTATTAAACACTATCAATTAACTCAGTT2580 TGACGATGAACGCATGCCAGATTTAGATAAATATGAACGTTCTATCAAGGATTATGATGA2640 TTCATCAGATGAATTCAAACCTTTCCGCGAGGTATCTGATAGTATGCCATATCCACATGG2700 CCAATGTACTTGGTACGTATATAACCGTATGAAACAATTTGGTACATCTATCTCAGGTGA2760 TTTAGGTGATGCACATAATTGGAATAATCGAGCTCAATACCGTGATTATCAAGTAAGTCA2820 TACACCAAAACGTCATGCTGCTGTTGTATTTGAGGCTGGACAATTTGGTGCAGATCAACA2880 TTACGGTCATGTAGCATTTGTTGAAAAAGTTAACAGTGATGGTTCTATCGTTATTTCAGA2940 TCAATGTTAAAGGATTAGGTATCATTTCTCATAGAACTATCAATGCAGCTGCCGCTGAAG3000 AATTATCATATATTACAGGTAAATAAGTATTATTAAACCCGCAAAATTTATAAGTATAAA3060 CAAGGAGTTCGGACTTAAACATATTTCTGTTCATAAGTCCGATTTCTTATTCAATTAAAC3120 CCGAGGTATTCAGTTCGAACGCCTCGGGTCATTTTATATAAATATATTATTTTATGTTCA3180 AATGTTCCTCATCATATCCGTTTCAATTGTCATCTCACACATTTTATAAATATGAGCAAA3240 TGTACTTATTTTCAAACATTACTGCCTAGCTTTAATTGACGTTATATTAACTATAAACTA3300 CTTTTCCATGACTCTACGGATTCAATGTCACATGAGCGTGATAAAATTTGTTCAATAATA3360 AAGTCATGTTTATCATCTGATCTATCACCAACAGCATCTTCTAAAACAGTAATATAATAG3420 TCTTTATCTACACTTTCTAATGCCGTGCTCAATACAGCTCCACTCGTAGAGACACCCGTT3480 AATACTAAATGATTAATATCATTTGCACGTAAATAAACTTCCAAGTAACTACCTGTAAAT3540 GCGCTAAAGCGTCGCTTAGAAATAATCGGCTCATCTTCTAGTGGTGCTAAATCTTCAAGT3600 ATTCGTGTAGATGCATCTGCTTCAGTAATCGCATATCCTTGAGCTTTAATTGTTGAAAAC3660 ACTTTATTACTCGAGGAGACATCATTAAAATGCTTATCTAACACTAAACGTATGAAAATG3720 ACTGGTATTCGATGTTGTCTTGCTGCTTCAATTGCTCTCTGATTCGCTTTAATAATATTT3780 TTTATTCTAGGTACACTACTCGCTATACTTCTTGCATATCCAAACTAATAGCGCCGTTTT3840 TCGAGACATCTTCATTCTCCTTTACTTCTGTAGTTCTAAGTCGTTAAATTCATTATAACG3900 TTAAAATGATGGACAATCTATTCATTGCATTTTGCATATACTTCACAATAATTTAAGGGG3960 GAAATAAGACGTCTTATATACTTAAAAAAATATATAGATGCTCTTCCCCCAATATAATTA4020 TGCTTTATTTTTCAACTTATTGCGTCGTGATAACCAAATCATTAGTACACCCATTGCACC4080 AACAATTACAGATATCGGCAACCAATGTTCTTTTATCGTTTCCCCGCTTTAGGCAAGATA4140 CATTACCATCAGCATTTAATAATCCACTTAACAATCCATTACCTTTACCAAGTGTTACGT4200 CTTTTCTGGCTTTGGTGTGGGTATATCTGGAATACTGTCTAATAAATTTGATCCTTGATT4260 CATTAAATTTGCTAACTTATTTAAATCCGTTGTTTTCCCATTTTTATTCAATCGATCTAG4320 TAAACTTGGACGATTTACTATTGGTGATAAAATATAGTCTATATCTTTTTTCGTTTGATT4380 GAGTCTCTTTTGTAAATTCAATAAATCATCCGCTTTACCATTCAATGCCGATTTAACTAA4440 ATTAAAAATTTTATTTTGATCTGTTTCTATTTTAGTAATTAAATCTGCCAGTAATTTTGC4500 CTTTTGTCTTTCTATACGTGTTGCTAAAATCGTTTCAATTGCTTGCTTTTTATCTTTGGC4560 ATTATTCAAAATTGCTTTTAATATATCATCTGAAGACGTGTCGCCAGTTGATGCAAAATG4620 TTTCTTCAATTGGTCAACGATTTGGCGATTTGATAATCCTTTATTCGTCCAATCTTTAGC4680 CAATTTATCTGCTTCAGCTTTTCCTAATTTCGTTTGTAAGATTTGAGAAATCAATAGCGA4740 CTTATCTTGTGATTGATCAATCAATGACGTTAATAAATCATCACTCGTTGTCAGAGATAG4800 TTGATCAATATGACGAGTAATTTGATCTGCAATTTGTTGATCTGTTTTACCATCAACACG4860 TATATCTTTTAGAATTTTATCTGCCTCGTCTTTATTAAATATACTTTCTAAAATGCTTTG4920 TGTAGCATACTTTTTATCATCAGTACGTGCAAGTTCTTCCAAAATAATATTTCGTTGACT4980 TTTTATACGCTCTTTCGTCTTATTTACTTCGCTCATTAAGTCTGATTTTTGATTTTTAGG5040 AAGTTGCGTATTTGCAATACGTTGATCTAAAGATTGTAACGTATTCAGTTTATGATATGT5100 GTAATGTTGCGTTGAGGCATTACTTTTAGCCAATTTTTCAATCATAGCATGATTAATTTT5160 ATCGCTTCCTTGTAATTTATCAGTGAGTTGATTACTATGGCTTTGATTCTCTTCATTTGA5220 AAGAAATTTATTTAACACAACATGTCCAGAACCATCATTATTTGGCGTTTTAGCTACTTC5280 ATGATTACTATCTGTTGTAGACACTGCCGGATCTTTCGATGCATCTTTCAATGCATCTTT5340 CGATTTGTGTATTTGCTGATTCAAATGGTCTAGGTCTTCTAACGCCTTATTTACCATTGC5400 TTCATCATTTTTATCATCTTTTTCTCCATATTTTGTTGTAGCCGTTTGTGACATATCATT5460 TTTCATTGCATTAAGATCGTCCTCGCCACTTTGTTGACCCCTATCAACATTTGAAGAAAC5520 CTCATTTAAATCTTTAAGCAATTGATCTAATTTACTGTCTATATCACTTTGACCGTTCAT5580 TTCAGTGTGAGAACTTTTATTTTCTTTGCTATCCAACTCATTAGCTCGTTTTATGATTTC5640 ATCTATTTGCGATGCTGTTTTCGCTTCATTTAGTTGTGCTTTATAATGTGCTTTAGATGA5700 AGCCGATAACTGTTTTAATTGCTCAATTTGACGAATTGCTTTGTCAACTTTGTCTAATAA5760 ATCTTGCTTAGATAATATCTCTTTTGAAATTTCAGTATCCTTTTCAGATGCAGCTTGGGC5820 ATCGTACGGCAAGATATTCGTTAAAATGATACTTGACGCCATCATTGTCGAACACGATAA5880 CTTTACATATAATTGAAACGGTTTCCCTCGATATTTAGCCATCAACATACTCCTTTCTCA5940 CTTACTTCCTTCAAAGAATTACATACTATTATATACCTGTTTACAAGAAATTTACACTTA6000 TCTATCTAGTTATTGTTGTTAGTAATTATCAACTTATTACTTAGCTTATATTTAAGTAAA6060 CAAAAAAGCATGACGTAATATCATATTGTCCATGTCGCTAACATCATATTACGTCAAATC6120 TTTTAAATTAAATGATGCTTTATTTTAGACTGCTTTTTCTTTTTAGCTTTCGAGCGCCTG6180 TTTAAAAACTTGCTCGAATTGTTCACGCGAGATTTCGTGTGCATGTGCTTTTTGTGCTAA6240 TAAAGCATCTCGAAACTGTTGTTGATCTTTCAAACTTTCTAACATTTGTATTAATTGGTC6300 TTTACTTTCCATTGTTATCTCATCATTATGCTCAAATAAGTGCTCTGATAATGTTACTTT6360 AGCATGGTGTGCGGTTTGACGATAACCTAAAATCAACAACTCATAGTCAAACGCTTGTTC6420 CACCGCATTTAAAATTTCATTACCCTCATTGATATCAAGATAAATATCACATAACTGGTA6480 TAGTTCATTTACCCTGTCAATATAATAGATGGTATAAGTGCACATTAGCATATTGATCAA6540 GTTGCATTAGCTTATCAGACATCTCTGTAATAGCAGCGATGTGAAAATTAAAATCTGGTA6600 AAGTTTCAACCAATACCTTGATGTTACGAAGTTGATCCGAGTTAGTTAATATTACAATTT6660 CTTTAGTATATCTATTACGACTACGATAGTTATATAGATATCCGCCTTGTAAAATACGAG6720 ATTGAACCTTTGCGTCTGCTATATTGAGCATCGTTTCATATTCGTTTTTATCTGGAATAA6780 TAATATTACAATGTCGTTTCATATCACCTTTACACATCAATTGCATATTTCCCGGGACAT6840 TACCATTACAGTGTTCTTGCCATACCAAAACATCACTACCTTTTGATGGCAAATTATATA6900 ACACTGAAAATGGTAGGGCTAGTGAGTTAATAACGAAATGATGTTCCGTAATTTCAAGTT6960 GCTTGATAAAAAATAATACGAATGCGAGCTTTGAAGGGAAAAAGTAAGACTTCCCTTGCC7020 AATCCAATATGACATCAGATGTTACAAAATTTTCATAAATCACTTCTTTACCTTCTGCTG7080 TCATATATTTCTTCAAGATCGCTTTACGATTTAAATCGTAACAGTTTGTGCAATTTAATA7140 CCATTCTTAGAATAATAATCGACAAATCGGACACGTTGTTGGTCATCAAACCATTCGACA7200 CGACTAACAATTCTAGGGCGCTCTCCACTTTGATAAAATATTTTGCCTCGTAGACGTCCC7260 ATATCATTAATTGTAGCCGAATTGTTGTTACCTTTAATTTCCCAAAAAGCTGGTACAGTA7320 ACCTGATTAAAAAATCGTGGTTTCATATTTTCTGTATTATGATTATCTGCAAAAAATTGA7380 TACGGTGATATAACATCGTCCGGTAAAAAGCCATTGTCATTGAGTACAATTGTTAAATCT7440 TCTTCCAACTTACTGGCTTTAAAAGACTCATATAACTTTCGTGAATGATCGTTAAAGTAA7500 TCAAATAATTTAATCATGTAGCACCTCTTGAACTAATGTTTCCCATTTTAAAATAATATC7560 TTGAGTCATAAATTGCTGTGCCACTTCATAAGAGATGTCATGTGGTGCCTGGGGACCATT7620 GTTAAAATACATTACAATGGCATGAGCTAGTTTTGCGATAACATCATCCACACTATCTTC7680 GTCGGTATCAAAAGGTACCAAGTAGCCATTTTCCCCATCTCGAATAAAGGTTGGGTTACC7740 ATAATTCACATTTAATCCAATCATACCTAGTCCTGAGCCTACCGCTTCCATTAGTGTTAA7800 CCCAAAACCTTCGCTAGTTGATGCAGAAAGAAATAACTCATAATCATTATAAATTTCATC7860 AAGTTTAACATGCCCTTAGTAAACCGAATATAATCTTGTGCGCGGTGTGTATCAATAATT7920 TTACGCAGTCGCGTCTTCTCGCTACCTTCTCCATAAATATCAAATGTTAATTCTGGCACT7980 TGTCGTTTAGCCACGATAACCGCCTTGACAAGCCAATCAATATGTTTCTCATTTGCTAAA8040 CGAGATGCACTAATCATCGCATATGGCTTTCTTGATAATTTAGGATATGATAACGCATCA8100 ATGCTTCCCACCGGDATAGTATAGACACGTGGACGATAACCTTGATATTGCTCAAATTGT8160 CGACAAACCATATGATTTTGAATATCTGTTGCTGTAATAAAGAAATCAATGTATTTAGCT8220 TTTGAAAATTGATATTCATAATAATTGTTCCATAGTATATGCTGCTCGCTCATCATATTA8280 TTACTATAATGATCAGCATGAATCACAACACCAACTTTACTATCACCTTTATGCTGCAAA8340 ACAGCCTGACCAATATCAGAAGCGCGGTCTAATATGACAATATCGTCTCGGGTTAAATTC8400 AATCGTTGTAAAAAGTATGCAATAAATTCCGTTTTGTTATACAACACCGCATCTTCAAAC8460 ACATATATAGAGCTGTCTCCATCAATATATTCGTTATAAGCGATGGAACCATCTTCATTA8520 TAGAATTGTCGCATATATAATTTCGCTTTATTATCAGCTGGTGCATAATACTCAGAAAAT8580 ATACGCGTATAACTATAAAAATCTTTACGTACTAACATACTATTAATTACAATTCTGCAC8640 GATCCACAACATCTTTTTGTTCATTTTGTAGATAACATGTTACAAATGATGATTTCCCAT8700 TAAAATATAGACGGACTATCTTACCATTTCTTTCTCTAAAACTAATTTCATGACCAAGCT8760 CACGTTCAATGTCATCTAACGTGTACGTTGTTGGTGCTATAGAAATATCACTAAAAATAC8820 TGATACAACCAAATAACTTCTTGATCTTTAAACCCAATGTTTTGCGTTAATGTCTGTATG8880 TTCTCTGACTGTATAAAATCTAAAAACACAAATTTAGTGTCTTGATTTGTACGTCTCAAT8940 AATTTAGCACGGTAAGCTT8959 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10207 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE:Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus aureus (B) STRAIN: Clinical Isolate SA- 24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: AAGCTTATGGACCTATTTTAGGTATATTGATTAGTTGGCTTGGATTAATTTCTGGAACAT60 TTACAGTCTATTTGATCTGTAAACGATTGGTGAACACTGAGAGGATGCAGCGAATTAAAC120 AACGTACTGCTGTTCAACGCTTGATTAGTTTTATTGATCGCCAAGGATTAATCCCATTGT180 TTATTTTACTTTGTTTTCCTTTTACGCCAAATACATTAATAAATTTTGTAGCGAGTCTAT240 CTCATATTAGACCTAAATATTATTTCATTGTTTTGGCATCATCAAAGTTAGTTTCAACAA300 TTATTTTAGGTTATTTAGGTAAGGAAATTACTACAATTTTAACGCATCCTTTAAGAGGGA360 TATTAATGTTAGTTGTGTTGGTTGTATTTTGGATTGTTGGAAAAAAGTTAGAACAGCATT420 TTATGGGATCGAAAAAGGAGTGACATCGTGAAAAAAGTTGTAAAATATTTGATTTCATTG480 ATACTTGCTATTATCATTGTACTGTTCGTACAAACTTTTGTAATAGTTGGTCATGTCATT540 CCGAATAATGATATGTCACCAACCCTTAACAAAGGGACGTGTTATTGTAAATAAAATTAA600 AGTTACATTTAATCAATTGAATAATGGTGATATCATTACATATAGGCGTGGTAACGAGAT660 ATATACTAGTCGAATTATTGCCAAACCTGGTCAATCAATGGCGTTTCGTCAGGGACAATT720 ATACCGTGATGACCGACCGGTTGACGCATCTTATGCCAAGAACAGAAAAATTAAAGATTT780 TAGTTTGCGCAATTTTAAAGAATTAGATGGAGATATTATACCGCCTAACAATTTTGTTGT840 GCTAAATGATCATGATAACAATCAGCATGATTCTAGACAATTTGGTTTAATTGATAAAAA900 GGATATTATTGGTAATATAAGTTTGAGATATTATCCTTTTTCAAAATGGACGATTCAGTT960 CAAATCTTAAAAAGAGGTGTCAAAATTGAAAAAAGAATTATTGGAATGGATTATTTCAAT1020 TGCAGTCGCTTTTGTCATTTTATTTATAGTAGGTAAATTTATTGTTACACCATATACAAT1080 TAAAGGTGAATCAATGGATCCAACTTTGAAAGATGGCGAGCGAGTAGCTGTAAACATTAT1140 TGGATATAAAACAGGTGGTTTGGAAAAAGGTAATGTAGTTGTCTTCCATGCAAACAAAAA1200 TGATGACTATGTTAAACGTGTCATCGGTGTTCCTGGTGATAAAGTAGAATATAAAAATGA1260 TACATTATATGTCAATGGTAAAAAACAAGATGAACCATATTTAAACTATAATTTAAAACA1320 TAAACAAGGTGATTACATTACTGGGACTTTCCAAGTTAAAGATTTACCGAATGCGAATCC1380 TAAATCAAATGTCATTCCAAAAGGTAAATATTTAGTTCTTGGAGATAATCGTGAAGTAAG1440 TAAAGATAGCCGTGCGTTTGGCCTCATTGATGAAGACCAAATTGTTGGTAAAGTTTCATT1500 TAGATTCTGGCCATTTAGTGAATTTAAACATAATTTCAATCCTGAAAATACTAAAAATTA1560 ATATGAAACAAATACAACATCGTTTGTCGGTTTTAATACTGATAAACGATGTTTTATTTT1620 GTTAGTACCACAATAAAAGCTAAGTTCGAAATGAACTTATAATAAATCAATCACAATCAC1680 TTTGTGTTAAAATATGTGTCAAAGGAAGTGAGGGTTTGTCATGACATTACATGCTTATTT1740 AGGTAGAGCGGGAACAGGTAAGTCTACGAAAATGTTGACCGAAATAAAACAAAAAATGAA1800 AGCAGATCCGCTTGGAGATCCAATCATTTTAATTGCGCCAACTCAAAGTACATTTCAATT1860 AGAACAAGCCTTTGTCAATGATCCGGAATTAAATGGTAGTTTAAGAACAGAAGTGTTGCA1920 TTTTGAACGATTAAGTCATCGTATTTTCCAAGAAGTTGGTAGTTATAGCGAACAAAAGTT1980 ATCTAAAGCTGCAACGGAAATGATGATTTATAACATTGTTCAAGAACAACAAAAGTATTT2040 AAAACTTTATCAATCACAAGCAAAATATTATGGGTTTAGTGAAAAATTAACAGAACAAAT2100 TCAAGATTTTAAAAAATATGCAGTAACGCCTGAACATTTAGAACACTTTATTGCTGATAA2160 AAATATGCAAACTCGAACTAAAAATAAGTTAGAGGATATTGCTTTAATATACCGTGAGTT2220 CGAACAACGCATTCAAAACGAGTTTATTACTGGTGAGGATTCATTACAATATTTTATTGA2280 TTGTATGCCGAAATCAGAGTGGCTAAAACGTGCTGATATATATATTGATGGTTTTCACAA2340 CTTTTCAACGATTGAGTATTTAATAATCAAAGGATTAATTAAATATGCGAGAGTGTCACA2400 ATTATATTGACGACAGATGGTAACCACGATCAATTTAGTTTTTTAGAAAACCATCGGAAG2460 TGTTACGACATATTGAAGAAATAGCAAATGAACTCAATATTTCTATTGAACGTCAATATT2520 TCAACCAATTATATCGCTTCAATAATCAAGATTTAAAGCATCTTGAACAAGAATTTGATG2580 TACTTCAAATCAATCGAGTGGCATGTCAAGGTCATATCAATATTTTAGAATCTGCGACTA2640 TGAGAGAGGAAATAAATGAAATTGCGCGACGTATCATCGTTGATATTCGTGATAAGCAAT2700 TACGATATCAAGATATTGCAATTTTATATCGTGACGAGTCTTATGCTTATTTATTTGATT2760 CCATATTACCGCTTTATAATATTCCTTATAACATTGATACAAAGCGTTCGATGACACATC2820 ATCCGGTCATGGAAATGATTCGTTCATTGATTGAAGTTATTCAATCTAATTGGCAAGTGA2880 ATCCAATGCTACGCTTATTGAAGACTGATGTGTTAACGGCATCATATCTAAAAAGTGCAT2940 ACTTAGTTGATTTACTTGAAAATTTTGTACTTGAACGTGGTATATACGGTAAACGTTGGT3000 TAGATGATGAGCTATTTAATGTCGAACATTTTAGCAAAATGGGGCGTAAAGCGCATAAAC3060 TGACCGAAGATGAACGTAACACATTTGAACAAGTCGTTAAGTTAAAGAAAGATGTCATTG3120 ATAAAATTTTACATTTTGAAAAGCAAATGTCACAAGCGGAAACTGTAAAAGACTTTGCAA3180 CTGCTTTTTATGAAAGTATGGAATATTTCGAACTGCCAAATCAATTGATGACAGAGCGAG3240 ATGAACTTGATTTAAATGGTAATCATGAAAAGGCGGAGGAAATTGATCAAATATGGAATG3300 GCTTAATTCAAATCCTTGACGACTTAGTTCTAGTATTTGGAGATGAACCAATGTCGATGG3360 AACGTTTCTTAGAAGTATTTGATATTGGTTTAGAACAATTAGAATTTGTCATGATTCCAC3420 AAACATTAGATCAAGTTAGTATTGGTACGATGGATTTGGCTAAAGTCGACAATAAGCAAC3480 ATGTTTACTTAGTTGGAATGAACGACGGCACCATGCCACAACCAGTAACTGCATCAAGTT3540 TAATTACTGATGAAGAAAAGAAATATTTTGAACAACAAGCAAATGTAGAGTTGAGTCCTA3600 CATCAGATATTTTACAGATGGATGAAGCATTTGTTTGCTATGTTGCTATGACTAGAGCTA3660 AGGGAGATGTTACATTTTCTTACAGTCTAATGGGATCAAGTGGTGATGATAAGGAGATCA3720 GCCCATTTTTAAATCAAATTCAATCATTGTTCAACCAATTGGAAATTACTAACATTCCTC3780 AATACCATGAAGTTAACCCATTGTCACTAATGCAACATGCTAAGCAAACCAAAATTACAT3840 TATTTGAAGCATTGCGTGCTTGGTTAGATGATGAAATTGTGGCTGATAGTTGGTTAGATG3900 CTTATCAAGTAATTAGAGATAGCGATCATTTAAATCAAGGTTTAGATTATTTAATGTCAG3960 CATTAACGTTTGACAATGAAACTGTAAAATTAGGTGAAACGTTGTCTAAAGATTTATATG4020 GTAAGGAAATCAATGCCAGTGTATCTCGTTTTGAAGGTTATCAACAATGCCCATTTAAAC4080 ACTATGCTTCACATGGTCTGAAACTAAATGAACGAACGAAATATGAACTTCAAAACTTTG4140 ATTTAGGTGATATTTTCCATTCCGTTTTAAAATATATATCTGAACGTATTAATGGCGATT4200 TTAAACAATTAGACCTGAAAAAAATAAGACAATTAACGAATGAAGCATTGGAAGAAATTT4260 TACCTAAAGTTCAGTTTAATTTATTAAATTCTTCAGCTTACTATCGTTATTTATCAAGAC4320 GCATTGGCGCTATTGTAGAAACAACACTAAGCGCATTAAAATATCAAGGCACGTATTCAA4380 AGTTTATGCCAAAACATTTTGAGACAAGTTTTAGAAGGAAACCAAGAACCAAATGTACGA4440 ATTAATTGCACAAACATTAACGACAACTCAAGGTATTCCAATTAATATTAGAGGGCAAAT4500 TGACCGTATCGATACGTATACAAAGAATGATACAAGTTTTGTTAATATCATTGACTATAA4560 ATCCTCTGAAGGTAGTGCGACACTTGATTTAACGAAAGTATATTATGGTATGCAAATGCA4620 AATGATGACATACATGGATATCGTTTTACAAAATAAACAACGCCTTGGATTAACAGATAT4680 TGTGAAACCAGGTGGATTATTATACTTCCATGTACATGAACCTAGAATTAAATTTAAATC4740 ATGGTCTGATATTGATGAAGATAAACTAGAACAAGATTTAATTAAAAAGTTTAAGCTGAG4800 TGGTTTAGTGAATGCAGACCAAACTGTTATTGATGCATTGGATATTCGTTTAGAACCTAA4860 ATTCACTTCAGATATTGTACCAGTTGGTTTGAATAAAGATGGCTCTTTGAGTAAACGAGG4920 CAGCCAAGTGGCAGATGAAGCAACAATTTATAAATTCATTCAGCATAACAAAGAGAATTT4980 TATAGAAACAGCTTCAAATATTATGGATGGACATACTGAAGTGCACCATTAAAGTACAAA5040 CAAAAATTGCCATGTGCTTTTTGTAGTTATCAATCGGTATGTCATGTAGATGGCATGATT5100 GATAGTAAGCGATATCGAACTGTAGATGAAACAATAAATCCAATTGAAGCAATTCAAAAT5160 ATTAACATTAATGATGAATTTGGGGGTGAGTAATAGATGACAATTCCAGAGAAACCACAA5220 GGCGTGATTTGGACTGACGCGCAATGGCAAAGTATTTACGCAACTGGACAAGATGTACTT5280 GTTGCAGCCGCGGCAGGTTCAGGTAAAACAGCTGTACTAGTTGAGCGTATTATCCAAAAG5340 ATTTTACGTGATGGCATTGATGTCGATCGACTTTTAGTCGTAACGTTTACAAACTTAAGC5400 GCACGTGAAATGAAGCATCGTGTAGACCAACGTATTCAAGAGGCATCGATTGCTGATCCT5460 GCAAATGCACACTTGAAAAACCAACGCATCAAAATTCATCAAGCACAAATATCTACACTT5520 CATAGTTTTTGCTTGAAATTAATTCAACAGCATTATGATGTATTAAATATTGACCCGAAC5580 TTTAGAACAAGCAGTGAAGCTGAAAATATTTTATTATTAGAACAAACGATAGATGAGGTC5640 ATAGAACAACATTACGATATCCTTGATCCTGCTTTTATTGAATTAACAGAACAATTGTCT5700 TCAGATAGAAGTGATGATCAGTTTCGAATGATTATTAAACAATTGTATTTCTTTAGCGTT5760 GCAAATCCAAATCCTACAAATTGGTTGGATCAATTGGTGACACCATACGAAGAAGAAGCA5820 CAACAAGCGCAACTTATTCAACTACTAACAGACTTATCTAAAGTATTTATCACAGCTGCC5880 TATGATGCTTTAAATAAGGCGTATGATTTGTTTAGTATGATGGATGGCGTCGATAAACAT5940 TTAGCTGTTATAGAAGATGAACGACGTTTAATGGGGCGTGTTTTAGAAGGTGGTTTTATT6000 GATATACCTTATTTAACTGATCACGAATTTGGCGCGCGTTTGCCTAATGTAACAGCGAAA6060 ATTAAAGAAGCAAATGAAATGATGGTCGATGCCTTAGAAGATGCTAAACTTCAGTATAAA6120 AAATATAAATCATTAATTGATAAAGTGAAAAATGATTACTTTTCAAGAGAAGCTGATGAT6180 TTGAAAGCTGATATGCAACAATTGGCGCCACGAGTAAAGTACCTTGCGCGTATTGTGAAA6240 GATGTTATGTCAGAATTCAATCGAAAAAAGCGTAGCAAAAATATTCTGGATTTTTCTGAT6300 TATGAACAATTTGCATTACAAATTTTAACTAATGAGGATGGTTCGCCTTCAGAAATTGCC6360 GAATCATACCGTCAACACTTTCAAGAAATATTGGTCGATGAGTATCAAGATACGAACCGG6420 GTTCAAGAGAAAATACTATCTTGCATCAAAACGGGTGATGAACATAATGGTAATTTATTT6480 ATGGTTGGAGATGTTAAGCAATCCATTTATAAATTTAGACAAGCTGATCCAAGTTTATTT6540 ATTGAAAAGTATCAACGCTTTACTATAGATGGAGATGGCACTGGACGTCGAATTGATTTG6600 TCGCAAAACTCCGTTCTCGAAAAGAAGTACTGTCAACGACTAACTATATATCAAACATAT6660 GATGGATGAACAAGTCGGTGAAGTAAAATATGATGAAGCGGCACAGTTGTATTATGGTGC6720 ACCATATGATGAATCGGACCATCCAGTAAACTTAAAAGTGCTTGTTGAAGCGGATCAAGA6780 ACATAGTGATTTAACTGGTAGTGAACAAGAAGCGCATTTTATAGTAGAACAAGTTAAAGA6840 TATCTTAGAACATCAAAAAGTTTATGATATGAAAACAGGAAGCTATAGAAGTGCGACATA6900 CAAAGATATCGTTATTCTAGAACGCAGCTTTGGACAAGCTCGCAATTTACAACAAGCCTT6960 TAAAAATGAAGATATTCCATTCCATGTGAATAGTCGTGAAGGTTACTTTGAACAAACAGA7020 AGTCCGCTTAGTATTATCATTTTTAAGAGCGATAGATAATCCATTACAAGATATTTATTT7080 AGTTGGGTTAATGCGCTCCGTTATATATCAGTTCAAAGAAGACGAATTAGCTCAAATTAG7140 AATATTGAGTCAAATGATGACTACTTCTATCAATCGATTGTAAATTACATTAATGACGAA7200 GCAGCAGATGCTATTTTAGTTGATAAATTAAAAATGTTTTTATCAGATATTCAAAGTTAC7260 CAACAATATAGTAAAGATCATCCGGTGTATCAGTTAATTGATAAATTTTATAATGATCAT7320 TATGTTATTCAATACTTTAGTGGACTTATTGGTGGACGTGGACGACGTGCAAACCTTTAT7380 GGTTTATTTAATAAAGCTATCGAGTTTGAGAATTCAAGTTTTAGAGGTTTATATCAATTT7440 ATTCGTTTTATCGATGAATTGATTGAAAGAGGCAAAGATTTTGGTGAGGAAAATGTAGTT7500 GGTCCAAACGATAATGTTGTTAGAATGATGACAATTCATAGTAGTAAAGGTCTAGAGTTT7560 CCATTTGTCATTTATTCTGGATTGTCAAAAGATTTTAATAAACGTGATTTGAAACAACCA7620 GTTATTTTAAATCAGCAATTTGGTCTCGGAATGGATTATTTTGATGTGGATAAAGAAATG7680 GCATTTCCATCTTTAGCTTCGGTTGCATATAAAGCTGTTGCCGAAAAAGAACTTGTGTCA7740 GAAGAAATGCGATTAGTCTATGTAGCATTAACAAGAGCGAAAGAACAACTTTATTTAATT7800 GGTAGAGTGAAAAATTGATAAATCGTTACTAGAACTAGAGCAATTGTCTATTTCTGGTGA7860 GCACATTGCTGTCAATGAACGATTAACTTCACCAAATCCGTTCCATCTTATTTATAGTAT7920 TTTATCTAAACATCAATCTGCGTCAATTCCAGATGATTTAAAATTTGAAAAAGATATAGC7980 ACAAGTTGAAGATAGTAGTCGTCCGAATGTAAATATTTCAATTATATACTTTGAAGATGT8040 GTCTACAGAAACCATTTTAGATAATAATGAATATCGTTCGGTTAATCAATTAGAAACTAT8100 GCAAAATGGTAATGAGGATGTTAAAGCACAAATTAAACACCAACTTGATTATCAATATCC8160 ATATGTAAATGATACTAAAAAGCCATCCAAAACAATCTGTTTCTGAATTGAAAAGGCAAT8220 ATGAAAGAAGAAAGTGGCACAAGTTACGAACGAGTAAGACAATATCGTATCGGTTTTCAA8280 CGTATGAACGACCTAAATTTCTAAGTGAACAAGGTAAACGAAAAAGCGAATTGAAATTGG8340 TACGTTAATGCATACAGTGATGCAACATTTACCATTCAAAAAAGAACGCATATCTGAAGT8400 TGAGTTACATCAGTATATCGATGGATTAATCGATAAACATATTATCGAAGCAGATGCGAA8460 AAAAGATATCCGTATGGATGAAATAATGACATTATCAATAGTGAGTATATTCGATTATTG8520 CTGAAGCAGAGCAAGTTTATCGTGAATTACCGTTTGTAGTTAACCAAGCATTAGTTGACC8580 AATTGCCACAAGGAGACGAAGACGTCTCAATTATTCAAGGTATGATTGACTTAATCTTTG8640 TTAAAGATGGTGTGCATTATTTTGTAGACTATAAAACCGATGCATTTAATCGTCGCCGTG8700 GGATGACAGATGAAGAAATTGGTACACAATTAAAAAATAAATATAAGATACAGATGAAAT8760 ATTATCAAAATACGCTTCAAACGATACTTAATAAAGAAGTTAAAGGTTATTTATACTTCT8820 TCAAATTTGGTACATTGCAACTGTAGTATTTTGATTTTCAAAAGAATAAAAAATAATTTC8880 GATTAAGTGCAAAGTCCTTGTAGCAGAATGAACACAACTCATTTTCAAAATTGTCTTACT8940 TATTTATTTGTTATTTGATAACGAAAAAAGTTATAATGTGAATTAAGATAAAGATGAGGA9000 GTTGAGAATGAATGAAATTCTTATCATTCAAGTATAATGACAAAACTTCATATGGCGTTA9060 AAGTAAAACGCGAAGATGCTGTATGGGATTTAACACAAGTATTTGCTGACTTTGCAGAAG9120 GAGATTTCCATCCTAAAACATTGTTAGCTGGTTTACAACAAAATCATACTTTAGATTTTC9180 AAGAACAAGTACGTAAAGCAGTTGTAGCAGCAGAAGATAGCGGCAAAGCTGAAGACTATA9240 AAATTTCATTTAATGACATTGAATTCTTACCACCAGTAACACCTCCGAATAATGTGATTG9300 CTTTTGGTAGAAATTACAAAGATCATGCGAACGAATTAAATCATGAAGTAGAAAAATTAT9360 ATGTATTTACAAAAGCAGCGTCATCTTTAACAGGAGATAATGCAACAATTCCAAATCATA9420 AAGATATTACTGATCAATTAGATTATGAAGGTGAATTAGGTATTGTTATTGGTAAGTCTG9480 GTGAAAAGATTCCAAAAGCATTAGCTTTAGATTATGTTTACGGCTATACAATTATTAACG9540 ATATCACTGATCGCAAAGCACAAAGTGAACAAGATCAAGCATTTTTATCAAAAAGTTTAA9600 CTGGCGGTTGCCCAATGGGTCCTTATATCGTTACTAAAGACGAACTACCATTACCTGAAA9660 ATGTAAATATTGTTACAAAAGTTAACAATGAAATTAGACAAGATGGTAACACTGGCGAAA9720 TGATTCTTAAAATTGATGAATTAATAGAAGAAATTTCAAAATATGTTGCACTACTACCGG9780 GAGATTATTATTGCAACTGGTACACCAGCTGGCGTTGGTGCAGGTATGCAACCACCTAAA9840 TTTTTACAACCAGGTGATGAAGTTAAAGTGACTATTGATAATATTGGAACGCTGACAACT9900 TATATCGCTAAATAATTATCATTTAAAAAGCTAACCAGGTCTTTATATAGATTGGTTAGT9960 TTTTTCTTGCTTTTCTAAAAAGGTGTTAAAGATAAATTATTTATAATGTTACCATTTTGA10020 GATGAAAGTGAAATATTGATATTAAGAAGTAGTTGATTATTTTACAGCAGATTCACAATA10080 TTCTAATAAGGGCAATGCAAATGTCATGTTCTTCCTCTCAAATATAGAAGTGTGGTAGAA10140 TATATATTCGTGTATAATCAAATCTAGATTAAATTACAAGCAAGTGGGTATTAATCCCAA10200 GAAGCTT10207 (2) INFORMATION FOR SEQ ID NO:3: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2082 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus aureus (B) STRAIN: Clinical Isolate SA- 36 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: AAGCTTTCTAATCTATCGTTAATGATTTGCTTTAAAATTGGGTCGAAGTTAATTGAAGGT60 GTGAAGTGTATATCTGTATTAATAACCATGTCATTCATTTGCTGCTTCACTTTGTTAACA120 AGTCTTCCGTCATATAAAAATAATGGTACGACAATCAATTTTTGATACCGTTTCGAGATG180 CTTTCTAAATCATGTGTAAAACTAATCTCTCCATATAGCGTTCTCGCATAAGTAGGTTTA240 TTAATCTGCAAATGTTGAGCGCATATTTGTAACTCTTCGTGTGCCTTAGTAAAATTTCCA300 TTAATATTGCCGTGTGCAACAACCATAACTCCAACTTGTTGTTCGTCACCTGCTAATGCG360 TCACAAATACGTTGTTCAATTAATCGTCTCATTAAAGGATGTGTGCCAAGTGGCTCGCTT420 ACTTCTACCTTTATGTCTGGATACCGTCGTTTCATTTCATGAACGATATTCGGTATATCC480 TTGAGATAATGCATTGCACTAAAGATTAGCAATGGTACAATTTTAAAATGGTCAACCCCA540 CTTTGAATCAACGTCGTCATTACCGTCTCTAAATCCTGATGCTCACTTTCTAAAAACGCA600 ATATCATAGTGATGTATATCATCTTTTACTAATTCAGAAATAAATGCTTCTAACGCTTGA660 TTCTGTCGTCCGTGCCTCATGCCATGTGCAACAATGATATTCCCATTCACATTTACCAAC720 CCTTTCACACGTATTGTATACCAAATCATTTTGTTTTTGTGAAAAGAATCACATTATAAT780 GTAAAATCAGGGAATTCCCTGATGCCTGTAGTCATGCATATTCCTTATACATTTTCCCTT840 TTTGTTAAATCAAAAAAAGCGACCGATATATGAATCCCTACTCAACATTTATTTGAGCAA900 GCATCAATATATCGGTCGCTTGTAGTGTATATTATTATCTTAAAATGGTGGTTGGCCTAA960 TATTGTTTCGTCAAAGCGCTCGGGTATCAATACTTTGCGCATGATCACACCTAAATCGCC1020 ATCATCATTTTCATGTTCGCTGTATATTTCATAACCTCTTTTTTCATAAATTTTAAGTAA1080 CCACGGATGCAATCTTGCAGATGTACCTAAAGTAACTGCCGCTGACTTTAACGTATCTCG1140 CAAAAATGCTCTTCAACATAAGTAAGTAATTGGCTACCATAGCCTTTCCCTTCATACTCA1200 GGATTTGTCGCAAACCACCAGACAAAAGGATAGCCCGAAATACTTTTCACACTTCCCCAA1260 GGATATCTAACCGTAATCGTAGATATAATTTCATCATCAATTGTCATGACAAATGTAGTA1320 TTTTTATCTATATTTTCTTTAACAGCATCTAAATTAGCATTAACTGAAGGCCAATCAATA1380 CCTAGTTCTCTTAGAGGCGTAAATGCTTCATGCATGAGTTGTTGCAATTTTTCTGCATCT1440 TGTTCACTTGCGAGTCGAATCATCGTTTTTGTCATATTAATCCCCACTCTTTTTTAAATG1500 ATTTAACCATATTTTATTTTTAAAATAAATATCCATCAAAGTGTATCAATAAATTTATCA1560 CATGTCAGAAAGTATGCTTCATCTGAATACACCAATACTCTCATGAAACTTATTAAAAAT1620 TACTCTCTCAACGTAAAAAAACCATTCAAATTCATGAATGGTTTGGAAGAATGATTCATT1680 GTTACGCTATTTAATCACTACATCTTAATTATTGTTGCTCTAAACGATTACGCTTACCAT1740 TTAAGAAAGCATAAACGAGACCTACAAAAATACCGCCACCGACAAAGTTACCTAAGAAAG1800 CAAAAACGATATTTTTTAAAACATGTAACCATGAAACTGCATCAAGGTTAAAGAATACCA1860 TACCTGCATATAGACCTGCATTGAACACAACGTGCTCATATCCCATGTATACAAAGACCA1920 CGACACCACAAGCTATGAAGAATGCCTTTGTTAAGCCGCCTTTGAATTGCATAGAGATGA1980 AAATACCAATATTAATAAAGAAGTTACAGAAAATACCTTTTGTAAAAATATTCAACCATG2040 TTGAATCAACAGTCTTTTTCTGAACTAAAGCTGTTAAAGCTT2082 (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2885 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus aureus (B) STRAIN: Clinical Isolate SA- 77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: AAGCTTTTGATTAATTTGGGCTTTAAAGTATTCCCAATTATAATTCTTCATGATTTTCTT60 ATTGGATTTCGAATTTGGTTTCATGCATTGTTGCCTCAAAGAACATGCTGAACAGTCATC120 GCATTCATATAGCTTGAAGTCACGTTTAAAACCATATCTATCATTACGGTATGCATATCT180 TTTAAAACCTATTCTTTTGTTATTAGGACATATAAATTCATCATTAAGTTCGTCATATTT240 CCAATTTTGAGTGTTAAAAATGTCACTTTTAAACTTTCTAGTTTTATCTTTAATAAACAT300 GCCATACGTAATAAGTGGCGTTTTATTAAAACATCTATAATAGCCATATAGTTTTGCTCA360 CTATCATAACTGCATCAGCTACATTAACTCTGGTAATACCGAGGATTTGAATCATTGTTA420 AAAATGGAATTAAAGTTCTAGTATCTGTTGGGGTTTGAAATAGGTCATAGGATAAAAAAA480 TTGAGAATTTGTCGCTATTTGTAAATTGTATCCTGGCTTAAGTTGGCCATTTTTCATATG540 GTCTTCCTTCATTCTCATAAAAGTTGCATCATGATCAGCCCAGAAAGCTATTTCTATCTT600 TAAGAATCCATTTTTGTTCTTCATATTTATTTTTTCTTTCGGAATAATCATCAAATTTCT660 TTTTGAACTTCTTAATCTCAGTTCTTTTTTACGGGTCTGTTTTCTAATTTGAGCACTCTT720 CGTTCTAAATAGAATGATTTAAATCTTCGATTTCTTTTATCTAAATGACTACCAATTAAA780 TCTATTTCTTCTCGTGATTTTGAATACTTTTCTTCCACACAAATGTATATCTATTGGCAT840 TAGCTTCTACTTATGTACCATCAATAAAAATTGAATTATTATCAATAAGATTTTGCTTTA900 AACATTGACTATGGAACTGAATAAATAAAGATTCAATTAACGCATCAGTATTAGGATTCA960 CTCTAAAACGATTAATAGTTTTATAAGAAGGTGTTTGATCTTGAGCTAACCACATCATTC1020 GAATACTGTCATGAAGTAATTTCTCTATTCTACGACCAGAAAATACAGATTGAGTATATG1080 CATATAAGATGATTTTTAACATCATTTTTGGATGATAGGATGTTGCGCCACGATGATGTC1140 TGAATTCATCGAATTCGCTATCAGGTATCGTTTCAACAATTTCATTTACATATCGCGAAA1200 TATCATTTTAAGGAATTCTAACAGAAGTTTCTATTGGTAGTGTAAGTTGGGCAAAGTGTC1260 TTATTTTTTTAAAGTATGTAAAAGTAAAATTACATGTTAATACGTAGTATTAATGGCGAG1320 ACTCCTGAGGGAGCAGTGCCAGTCGAAGACCGAGGCTGAGACGGCACCCTAGGAAAGCGA1380 AGCATTCAATACGAAGTATTGTATAAATAGAGAACAGCAGTAAGATATTTTCTAATTGAA1440 AATTATCTTACTGCTGTTTTTTTAGGGATTTATGTCCCAGCCTGTTTTATTTTCGACTAG1500 TTTGGAGAATTTATTGACATTCACATTATTTAAACGGCAACAAAGATTGTTTTATTTTGA1560 TAGGCATTATATGGTGTTAAAAAATTTGCATGAAAATTAAAAAATGCTTCGTTCAGGAAG1620 GTGTCGTAATTTACCTATTTGCTGAATGAAGCATTTTATTTTTAAATATGATAGCCAATA1680 TAACAAGCTATAAATCCAATGATGAATTGTAAAAGTGAATAATTGAGAAAAAGGTTAATA1740 TCAAATTTTGGTGTCATCATTAATGTAAGTTCCTTGGCTAACGTTGAGAAAGTTGTTAAG1800 CCACCTAAAAAAACCGGTGACAAAGAACGCAGGGAACCATGAGATTGAAATTGATAGGCC1860 TATAGTTAATCCAATTAAAAAACTACCAACTAGATTTACTATCAATGTTGCGATAGGTAA1920 CTTTGAAGTAAATTTATGATTAAAATAATCAGTAATGGCACTTCTAGCAATTGCGCCAAA1980 ACCGCCGCCAATCATGACTAAAATGATTGATATCATGATAAACCACCACCTAGTTTTATA2040 CCGACGTAACATAACAAAATACCAAAGACATAACTTGTTACAGCATATAGTAGTAAAGTT2100 ATAAATTGTTGATGATCAAACATATGTATTAATTCTAATTGAAATGTTGAAAAAGTCGTT2160 AAAGCACCAAGAAAACCAGTCGTAATAGCTTTTTTTAGGGTCGGATGGTTTGAAAAAAAT2220 GCAATTGTTAAGGCTGTTAGCAATCCCATTACAAAGGCACCAGTCAAATTGGCTATCAGT2280 GTTCCGATTGGAAAACCTCCGTCAGTATTCAGAAAAGAAATGAGGTAACGTAATAAAGCG2340 CCTAAAGCACCACCGATAAAAATATATACATATTGCATTTGGTTCACCTCGAAAAGAAGT2400 AGTTTGAATTTAAAAAAGAGGTTTTGGCAACACGACGACAAAAATTGTCGATGCATTATC2460 AAACCTCATTATATGTTATATCTTGTTGTATAACTATAGCGATTAGATGCATAGTTATGA2520 TTTCGAAAATCTAATATTTTTTATACGCAACAACGTCATCAAATTGTTTTACTCATTATA2580 GCATGATACATTGTATTGTTTTGTATTAACGCTACATTGACATTTTATCTTTTTTAAATA2640 AAACCGAATGTACGACAATTGAAAAGATATGTACTAAAATAACAATTAGAATAATCCAAG2700 GCAAACTTTTACTCGCAATTCTAATCCAATCTGCATCAGGCTTTAGTGATTTAATTGAAC2760 GATCTGCAAAAATTATAGACAAAATTAGTACAATTGAGTTAATAACACTGCAGAAAAGTA2820 TTAATTTAATAAAAGAATTAAAAAATCCACTTAGGAAAACGTTATTTGTATTAAAGAAAA2880 AGCTT2885 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2362 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus epidermidis (B) STRAIN: Clinical Isolate SE- 3 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: AAGCTTCACAACTTGAAAATATAGCACAAACATTAAAGGATTTAGGTAGAAAACGAGCAA60 TTTTAATTCATGGTGCAAATGGGATGGATGAGGCCACGCTTTCTGGTGAAAATATCATTT120 ATGAAGTTAGCAGCGAAAGAGCATTAAAAAAATATAGTTTAAAAGCAGAAGAAGTCGGTT180 TAGCTTATGCAAATAATGACACGTTGATAGGTGGTTCACCTCAAACAAATAAACAAATTG240 CATTGAATATCCTAAGTGGCACGGATCACTCAAGTAAACGAGATGTAGTTTTGTTAAATG300 CTGGAATTGCTTTATATGTTGCTGAGCAAGTGGAAAGTATCAAACATGGCGTAGAGAGAG360 CGAAATATCTCATTGATACAGGTATGGCAATGAAACAATATTTAAAAATGGGAGGTTAAG420 TAATGACTATTTTAAATGAAATTATTGAGTATAAAAAAACTTTGCTTGAGCGTAAATACT480 ATGATAAAAAACTTGAAATTTTACAAGATAACGGAAATGTTAAGAGGAGAAAGCTGATTG540 ATTCACTTTAACTATGATAGAACATTATCAGTTATTGCTGAAATAAAATCGAAAAGCCCA600 TCTGTACCTCAATTACCGCAACGTGATCTTGTTCAACAAGTTAAAGATTATCAAAAATAT660 GGTGCTAATGCTATTTCAATATTAACTGATGAAAAATACTTTGGCGGTAGTTTTGAACGA720 TTAAATCAGTTATCAAAGATAACATCGTTACCAGTTTTATGTAAAGATTTTATTATTGAT780 AAAATTCAAATAGATGTTGCAAAACGAGCTGGTGCATCTATTATTTTATTAATAGTAAAT840 ATTTTAAGTGATGACCAATTAAAAGAATTGTATTCATATGCAACAAACCATAATTTAGAA900 GCTCTAGTAGAAGTTCATACAATTAGAGAACTTGAACGTGCACACCAAATTAACCCTAAA960 ATTATTGGTGTTAATAATCGTGATTTAAAACGATTTGAAACCGATGTTCTACATACAAAT1020 AAATTACTTAAGTTTAAAAAGTCTAATTGCTGCTACATTTCAGAGAGTGGCATTCATACA1080 AAAGAAGATGTTGAGAAAATAGTAGATTCAAGTATTGACGGTTTACTTGTAGGGGAGGCA1140 TTAATGAAAACAAATGACTTAAGTCAGTTTTTTGCCTAGTTTAAAGTTAAAGAAGAATCT1200 CTATGATAGTTAAATTTTGTGGTTTTAAAACCGAAAGTGATATTAAGAAAATTAAAAAAT1260 TAGAAGTTGATGCAGTAGGGTTTATACATTATCCCGATAGTAAGAGACATGTCTCACTGA1320 AACAATTAAAATATTTGGCTAAAATAGTGCCAGATCATATAGAGAAAGTAGTGTCGTAGT1380 AAATCCTCAAATGTCCACCATAAAGAGAATAATTAATCAAACTGATATTAACACAATCCA1440 ATTACATGGAAATGAAAGCATTCAATTAATTAGAAATATTAAGAAACTTAATTCAAAAAT1500 AAGAATCATAAAAGCAATTCCAGCAACAAGAAATTTAAATAATAACATTCAAAAGTATAA1560 AGATGAGATAGACTATGTTTATTATAGATACACCATCAATCACATACGGAGGGACAGGTC1620 AAAGTTTTGACTGGAAATTATTAAAAAAAATAAAGGCGTTGATTTTCTCATTGCGGTGGT1680 TTGGATTTTGAAAAGATAAAACGATTAGAAATATATTCATTTGGACAATGTGGTTATGAC1740 ATCTCAACTGGCATTGAGTCACATAATGAAAAAGATTTTAATAAGATGACTCGAATATTA1800 AAATTTTTGAAAGGAGACGAATGATTAATGAAAATTCAAACAGAAGTAGATGAATTGGGC1860 TTTTTCGGTGAATATGGTGGCCAATATGTACCTGAAACATTGATGCCAGCTATTATTGAA1920 CTTAAAAAAGCATATGAGGACGCGAAATCAGATACTCACTTCAAGAAAGAATTTAATTAT1980 TATTTAAGTGAATATGTTGGTAGAGAAACGCCTTTAACATTTGCTGAATCATACACAAAA2040 TTGTTAGGTGGTGCCAAAATATATCTTAAAAGAGAAGACTTAAATCACACTGGTGCTCAT2100 AAAATTAATAACGCGATAGGACAGGCACTATTAGCTAAAAGGATGGGGAAAACTAAATTA2160 GTAGCCGAAACAGGTGCTGGTCAACATGGTGTAGCAAGTGCCACCATCGCTGCTTTATTC2220 GATATGGATCTTATTGTTTTCATGGGAAGTGAAGATATCAAACGTCAACAACTTAACGTA2280 TTTAGAATGGAATTGCTAGGAGCTAAAGTAGTGTCTGTGTCAGATGGGCAAGGAACACTA2340 TCAGATGCTGTAAATAAAGCTT2362 (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8654 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus epidermidis (B) STRAIN: Clinical Isolate SE- 22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: AAGCTTGTTTTATTGCTTAGTTATATTTCCAATAACACTCATTTTATATGTACGTATTGC60 CAAAAAAAATTATCTATACAGTAATAAGTATGAAATGAGAACTGGAATAATCATTGGTAT120 TATTGCTTTAATTCTAGTAATTATGCAAGGGTTTCACTTTAACTGGGCTATTATTCCTAT180 TTCTATCTATGGTCATCAGTTTGTATTTTTCGCTGGAATTATTTTAAGTCTTGTTGGTAT240 ATTCTTTAAACGTATAGAATTTGTAGGAGTTGGCTTACTATTTTGTCAAAAACATAGATG300 CAATGGTAACTGACCCGGAAATTGCACAGTTTTTCTCTTTAGCAATTTGGATTATACTTG360 TTGTGCTAATCATTTTTTATACGATACGTTTATCTGAACGCACTAAATCATCATCATATA420 CAAAGATTTAAACTCAGAAAATATGCTAGACATATCTTTCTGAGTTTTTTAATTTATTAA480 AATATATCATTTGTTTACCATATAAGTTTGTTTTAGAAAATGAATCACTATTTTAATATA540 CAAATAATTTAATTACACTGAAAATAACCTAAAAGCGTAACACTATTTTAATATGGGTAT600 ATAAATGACTAAAGGGAGGTGCCAAGATGAATAAAATTCAAATTTGTAATCAGATTGAAC660 TTAACTATATTGATGAAGGCGAAGGCATCCCCATCATTTTAATTCATGGATTAGATGGAA720 ACTTGGCAGGATTTAAAGATTTAAAAAATGAACTCAAGAAGCAGTATAGAGTAATTACTT780 ATGATGTCAGAGGTCATGGAAAATCTTCACGAACAGAATCATATGAATTAAAAGATCATG840 TTGAAGATTTAAATGATTTAATGGGAGCATTAAATATCGATTCTGCACATATTTTAGGAC900 ATGATATGGGGGGCATCATTGCGAGTGAATTTACTGAAAAATATCAATATAAAGTGATTA960 CATTGACAATTGTTTCGGCCAAAAGTGAAGACATTGCAAATGGTTTCAACAAATTAATGG1020 TTGATTACCAAGAAGAATTAGCAGGCTTTAATAAATCTGAGGCAATGATTATTTTATTCT1080 CTAAATTATTTAAAGAGAAAGATAAAGCAATGAAATGGGTATCAAAGCCAAAAATTATAC1140 AATAGACCAACTCCGGAAGAAAGTGCAATTGCAGTACGTGCATTGCTTAATATTAAAGAT1200 TTAACTCGTGTTCATCATAATGTGTCCATACCTACTTTAATTGTGAATGGTAAGTATGAC1260 CCACTCATACAAAATAAAAGTCATTATGATATGGATCAATATTATGATCAAGTTACAAAA1320 ATTGTATTTGATAATTCAGGACATGCACCACATATCGAGGAACCAGAAAAATTCCTGAAA1380 CTCTACTTAGATTTTGTTAGTTAAAAAATAAGAACATAAATAAAAACCCTTAAATGATTA1440 TTGTCGGAAAATCATTTGAGGGTTTTGTAGTAGCAGTAAAGTTTGGACTCAGATCACTAT1500 CGTATTAACTTAATAAAAGAGTAAAACAGTCTTATCTTTCATAAGTGAAAGAAATATCTG1560 TTTNACTCCCTAGCCATTATACTTCATTTCATTATTTGCTTCTGTGATACGGTTGTTTAC1620 TCGTTTAAGTAAATCATCGATTTTTTTACGCTGCTTAGAATCTACTAAGATTAAAACAGT1680 TCTTTCATCGTGTTCATTACGTTTTTTATTAAAGTAATTTTCTTGAGATAAATTTTTAAC1740 AGCTTTAACAACTTGAGGTTGTTTATAATTTAAGTGATTGATAATATCTTTAAGATAATA1800 TTCCTCTTCTTTATTCTCACTAATATAAGTTAATACTGCAAATTCTTCAAAGCTGATTGA1860 GAATTCTTTTTTAATTATTCCTTTTAATCTGTCAGCATAAGTGACCATAGCTAATAATTC1920 AAAGCAGTCATTGATTTTTGAAATAGCCATTAATGAAACCTCCCTATTTATATCATATCC1980 ATAAATCTTAAAACCCATCTTTTTAAATTTAAAGATAGTTAATTATATTATTGAATTAAG2040 ATTACTTGGATACTATACCCTAATTTATTAATTTATATCTATTTTTCTTATGAAAATACG2100 AAAGTGTCCGTCATAATATAGTATTAATTTAAATTTAAAGAATATATTTAATGCTATATT2160 ATTTAGTTAATTATAACTAAATAAAATTAAGAAGTAAACAAATAAGTGTTTATAAAACAA2220 ATTATCTTTTAAAGTTTATACTTGAATTAGCAATGTAGCATTTGCTATATTCAAAAAAAT2280 AAGATTGTTTCTAATTTTCCTTAATTTAATAAAAATTATACTAAAAAGAATACTTTTTGG2340 AAAGAATTTTACTAACATTTTTTATATATAAATGTTTATTAATTTAGAAGTAGGATTTTT2400 AACAACTTTTTCATCTATCAATAAGCCTTTAGTTATATTAATATACCCACTTTTTAAACT2460 CTTTTTGTATGTTACTTCTCTTTTTGTAGAATTAAAACATAGCGTTTTTGAACAATAGCT2520 GACGTAGGTAACTCTATGTCATTTGAGGCTAATTTGATTTTAAAGTGTGTTCCAATTTGA2580 TGATTGGGTTGTGTAGAAAGTAAAATGTCGTAATATGAGACGCCATTTTTTATTTTTGAT2640 GGTATATTCGAAATTTCTTTAATTTTACTAGTAAATTGAGTGTTGTCACTAGATGTTACA2700 GAAATATTTTGATTTATTTTTAATAAATTCAACTCAGATTCTGATATATTAGCACGAATA2760 ATACGTTCGTTGCTATTAATTTGCACTATCTTTTCGTTTGGTTTTGAAGGGATAGAATTA2820 ATATATGAAATACTTCCATTAATTGGTGAAAATAAAGTGGATTTAATTGAGGATTTAGTT2880 TGAATCATTTGTAATTTTAGCTGATTAAGGAATGAATAATAATGTAAATCATTTTTAGAA2940 TTTAAAGTTTTGTTGTTACGTTCATTACTAAGTGTATTTTGGAGTTCCTCATATAAATGA3000 TCTTTTTCATAATTGTAATATTCTAACACTGGAGTGTTTTTAGATACTTTGCTATGATTT3060 TTTACTAAAAGTTTTTGGAGTTGTCCTAAAGTGGGAGTGTAGTAGAAAATATAGCTGTTA3120 AGAGGGGCTTGTATACCAGTTGTTGAAAGGAGTAATTTGGGCTTTGCTTTTATAGTTTTT3180 ATATTTTTAATATCTTCTGTTTTAGAAGTTAATTTAGAGAAAGTAATGTAACTAAAACTA3240 CAAGTTGTGAGAATGAAAATGAATAGTAATGAAGAAATAACGATGCGTTGCTTGGTCATG3300 GATGTTCACCTCATAATATTATTGTGAGGTTATTATACACTATTATTTTAAATGAAATAT3360 ATTAATTTTAAATAAGCATTACTTTTGGTTTGTATATTGTTTTATTTCAAAAAATAAAGT3420 AAATCAATTTAATAAATTGAAAAATAGAAGGCTATCTTTAATTTTAAAATATATGATTCT3480 ACATAAATGTTACTATAAGAAGAATCACTCATAAAAACTGCCAACAAAGACAAAATCTTT3540 GTTGGCAGTTCGAAATAGACATTTATTTGTATGAGGAATCTACATTAATATAAGCGGATA3600 ATTTTTATTCAGAATAAGGAATTTAAAATAATCGTAATAAAATAATACCTATAGCTATAC3660 ATAATAATCCACCTAACTTACGTGATGTTATTTTGTTTTTAGGTGAACCCAACAAACCGA3720 AATGATCGATAATAATACCCATAATCATTTGGCCCATCATAGCAATTATAGTAGTTAAAG3780 CTGCTCCTAAGAAAGGCATTAAAATAATATTAGATGTTACGAATGCCATTCCTAGTATCC3840 CTCCAATAAAATAAATAGATTTAATCTTACCTAGTGTTTTATGAGTAGATGATATTTTCA3900 GACTACGATTAAATACTAATGTTAATATAAATAACGCTATTGTACCAACGCTAAATGATA3960 TGAGTGAAGCAAATATGGATGAGTGTGTGTGTTGAGCCAGTGTGCTGTTGATTGTTGTTT4020 GGATTGGCGGACGAAACCAAATACGAATCCAATAAGCAACCAGAATACTATTGGTGTATT4080 CTTATGTCTATTAACAGGATGTCTACGAACATAATTCATAAATATAATTCCAGTAATTAA4140 AAATATAATTCCAACACCTTTAAATAATGTAAAAGATTGTTGATGGGCGCCCAATAATCC4200 AAATGTATCAATGATTACACCCATAATAATTTGCCCTGTAACCGTAATAACAACAGTAAG4260 TGCTGCGCCTAATCTTGGTAATAATAATAAGTTTCCAGTTAAATAGATAACACCTAATAG4320 TCCTCCTAGGACCCAAGTATAGTTAAGTGTTTGCTTAGAAAAGAATTCTGGTGTTAATAC4380 TTGTGGATGAATAATGATATTAAGCACAAGTAAGCATATTGTTCCGACAGCAAAAGATAT4440 GGTTGAAGCATAAAAAGATGAACGGGTAAATTGGCTTAGCCTTGAGTTGATTGAAGTTTG4500 AATAGGAAGTAACATGCCAACAAAAATTCCTAAAAGATATAGAAAAAACAATGATAAAAA4560 CCAACTTTCTCAATTTAATATGATTATCATACCATTCATAATCATGTTTCTAAAATGATT4620 GAGCCATAAGCAAAGTATAGAAATAAGTTGTGAATGTTCCGAGGTGTCATACAGCCGATA4680 CTATTTTGATGAATCATTATAATAAAATGCACATTAAACAAGTTTTAGAATTAAAAAAAG4740 CGAGACATCATTTTGAATTTGATATCTCACTTCATATTAATAAAAGAACAATGTAAATTA4800 AGTTCTTTTTTAGACTTGAACAATTTTAAAAAATTTGTTCTTCGATAAGTCTTTTTTATG4860 ATTTTAGTACTTTAAATAAAGCGTCAAAAATAATGTTTTATGAATTAATTTTTATCTTCA4920 AATATAACAGTTGTCCTTTTATCAATAAGTTGTGCAGCATAAATTTTGACAGGCTTTCCC4980 AAACTAAATCTTAAAATGTCTAATTCTAAAATGTCTAATTCTAAAAGTTGGTTCATACTT5040 TCTTTAATTAATTGTTCTGTAGTAATAGCGTTAAAATCGGGTAATAGTAATTTGACGGGT5100 TTATTAAGATTTGATTTAAATACGAGTTCCAAAGTTTTTGACATACTGATGTATCCTCCT5160 TAAATTAAAGATTCTGTTTTAACGATCTCGACTTTGTCATACTCTTCGCCACTGAACGTT5220 CAATGATGGAACGAAAAGATTTGATTTGATCATTAGAAACAAGCGGATTAATGTTAGAAA5280 AACGACGCTTATGTTCGACTACTTTACCTTCAGAATTATGTTTGATTTGAGTAAAGATAA5340 TCGTCACTTGATTGACTTCATTCATAATAAAACCTCCTTTCACTATATATATCGAAATAG5400 ATTGAAAAAAAAGGACACATTTTTTGAAAAATATAGGCAAATGCCTTTGATGTGATACAA5460 ACGTCATTTATCATTAATTATGAAACCTGTTTTAGAAGGTATATGAGGTAAGTAGAATTG5520 TTAAGTTGTAAAAGAAAAAATTGGAACCTGATATTTAAAATAACCAACTTAAAAGATTGA5580 TCAGTGTCTAAAATTACTATTTATATATGAATTAAAATATTAAGATCTCCCAATATGAGA5640 ATGAATTAGTTTAAGTTTATCGATGATTGAAAAATTATAGCCTCATGGATTCTATCTTAT5700 ATAAAATAAAGTTCTATTCCCTTTTGGATATAAATAAGAATAGTTACCTTTTTGTGATAT5760 GCCAATTCAGAAAAAAAGCGACAGTGCTTGAATCTATGTATGCTCAATAAACTCATTCAA5820 ATCAACTAGCAATATCAAATCATAAATCGTGTTGCACCATAATAAGGATTAAAACCTGTT5880 AGTTTAACTAATTTAAGAAAAACATTTGATTATCTTCTCTTTCAATCGGGAATATTAATT5940 TCTATCATTCAACAATATTTTGGATATCAGATAACTTAAGAAATATTGAGATTTATTGAA6000 ATACGATATGTTTCAAATCGCCATACAATGATTACACTTAATAAATGATTACACTTAATA6060 TAAATGTAAAAAGAAAAGGAGGGGTTAAATGAGTTTAGTATATCTTATGGCGACTAATTT6120 ATTAGTCATGCTCATAGTTTTATTCACTCTGAGTCATCGTCAACTAAGAAAGGTTGCGGG6180 CTATGTTGCATTAATAGCTCCTATTGTGACATCTACATATTTTATTATGAAAATACCAGA6240 TGTGATTCGAAATAAGTTTATTGCTGTTCGATTACCATGGATGCCTTCAATTGATATTAA6300 TTTAGATTTAAGATTAGATGGTTTAAGTTTAATGTTCGGCTTAATTATTTCGCTAATAGG6360 TGTGGGTGTATTTTTTTATGCTACGCAATATTTATCCCACAGTACGGACAATCTTCCTAG6420 ATTTTTCATCTATTTACTATTATTTATGTTCAGTATGATTGGCATTGTAATAGCTAATAA6480 TACCATCTTAATGTATGTATTTTGGGAACTCACAAGTATTTCCTCATTCTTGCTTATATC6540 CTATTGGTACAATAATGGTGAAAGTCAATTAGGCGCCATTCAATCTTTCATGATTACAGT6600 GTTTGGTGGGCTAGCGTTATTAACAGGATTTATCATTTTATATATCATTACAGGAACAAA6660 CACAATTACTGATATCTTAATCAACGCAATGCAATTTCACGACATCCTTTATTTATACCA6720 ATGATTTTGATGCTATTATTAGGTGCTTTTACCAAATCTGCACAATTTCCGTTTCATATT6780 TGGTTACCAAAGGCCATGGCAGCACCTACACCAGTAAGTGCTTATCTTCATTCGGCAACA6840 ATGGTAAAGGCTGGAATCTTTTTACTATTTAGATTTACACCTTTATTGGGACTTAGTAAT6900 GTTTATATTTATACAGTGACATTTGTTGGTCTAATAACTATGTTATTTGGATCTTTAACT6960 GCTTTACGACAATACGACTTAAAAGGTATACTCGCTTATTCTACAATAAGTCAATTAGGT7020 ATGATTATGACAATGGTAGGTCTAGGTGGCGGTTATGCTCAGCACACATCAGATGAATTG7080 TCTAAGTTTTATATTTTAGTTTTATTTGCTGGCTTATTCCATTTAATGAATCATGCGGTT7140 TTTAAATGTGCATTATTTATGGGCGTTGGTATCATTGATCACGAGTCCGGAACACGTGAT7200 ATTCGTTTGCTAAATGGTATGCGTAAAGTCTCCCCTAAAATGCATATTGTCATGTTGCTC7260 GCTGCATTATCTATGGCAGGTGTTCCTTTTTTAAATGGCTTTTTAAGTAAGGAAATGTTT7320 TTAGATTCGTTAACTAAAGCAAACGAACTTGATCAATATGGCTTCGTATTAACGTTTGTG7380 ATTATTTCAATAGGTGTCATCGCGAGTATATTGACTTTTACTTATGCACTTTACATGATA7440 AAAGAAACATTCTGGGGAAATTACAATATAGAAAAATTTAAACGTAAACAAATACATGAA7500 CCATGGCTATTTAGTTTACCAGCTGTGATTTTAATGTTACTCATTCCAGTTATCTTCTTT7560 GTTCCAAACGTTTTTGGCAACTTTGTTATTTTGCCCGCAACCAGATCTGTATCTGGGATA7620 GGGCGGAGGTTGATGCATTTGTGCCACATATTTCTCAGTGGCATGGTGTGAATCTCCATT7680 AATTTTAAGATAGTGTATATATTGGACTATTTTAGCTCTAGTGTGATTGGAAAGAGGTTA7740 CGCATCAAATAATCAAAAGTGCTCGATTACAGTGGCTATCGGAAATTTATAGAGAATTTG7800 AATTATACTCAGCCCGTGGTATACGTGCATTGATGAATAATAAATTGAATTATTACATCA7860 TGATTACATTATTTATTTTTGTAGCTATTGTAGTTATGGATATTTGACTGTGGGTTTTCC7920 TCATGTACTCAGCTTCATATTAGTTCTTTCGGACCGTTGGAAGTTATCTTATCAGTTGTA7980 ACATTGATTATCGGCATTTCATTAATCTTTATTCGTCAACGACTAACGATGGTGGTATTG8040 AATGGAATGATTGGATTCGCAGTTACATTATATTTTATTGCAATGAAAGCTCCAGATTTA8100 GCTTTAACACAGTTAGTTGTTGAAACTATTACGACAATCTTATTTATTGTTAGTTTTTCG8160 AGACTACCTAACATCCCTCGAGTTAAGGCAAATTTAAAAAAAGAGACCTTCAAAATCATT8220 GTGTCACTTGTTATGGCATTGACGGTGGTATCACTTATTTTTGTTGCTCAACAAGCAGAT8280 GGTATGCCTTCAATTGCTAAATTTTATGAAGATGCATATGAACTTACAGGTGGAAAAAAT8340 ATTGTCAATGCTATACTAGGTGACTTCAGAGCTTTAGATACTATGTTTGAAGGACTAGTG8400 TTAATCATAGCTGGATTAGGTATTTATACGTTACTTAATTACAAAGATAGGAGGGGGCAA8460 GATGAAAGAGAATGATGTAGTACTTAAATCAGTTACAAAAATTGTAGTGTTTATTTTGTT8520 AACATTTGGATTTTATGTATTTTTTGCTGGCCATAATAATCCAGGTGGTGGCTTTATTGG8580 TGGCTTGATTTTTAGCTCGGCATTTATCTTAATGTTTCTTGCCTTTGATGTAAATGAAGT8640 GTTGAAAAAAGCTT8654 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5024 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus epidermidis (B) STRAIN: Clinical Isolate SE- 32 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: AAGCTTTTTGATTTTTAAAGAAAAAATTAAACAAGGGGGCATTGCTTATGGTCAATAGAA60 GAAAGATATCAATTATTGGCGCGGGACATACAGGTGGGACTCTAGCATTCATTCTTGCAC120 AAAAGGAATTAGGAGATATTGTGTTGATTGAACGCCAGCAATCAGAGGGTATGGCTAAAG180 GAAAGGCGTTAGATATTTTAGAAAGCGGACCCATTTGGGGGTTTGACACATCTGTACATG240 GTTCAGTAAATATAGAAGATATTAAAGATTCAGACATAGTGGTGATGACTGCAGGTATAC300 CTAGGAAATCAGGAATGACAAGGAGAAGAATTAGTTCAAACTAATGAACAAATAGTACGA360 GAAACTGCATTACAAATTGCAACGTATGCACCTCATTCAATAATTATTGTATTGACTAAT420 CCGGTTGATGTTATGACATATACTGCATTTAAAGCATCAGGTTTTCCTAAAGAACGTATT480 ATTGGTCAATCTGGAATTTTAGACGCTGCAAGATATCGAACTTTTATTGCTCAAGAACTT540 AACGTGTCTGTCAAAGATGTAAATGGGTTTGTTTTAGGTGGACATGGTGATACGATGTTA600 CCTTTGATTAATAACACACACATTAATGGGATTCCAGTTAAGCATCTTATTTCTGAAGAA660 AAGATTGATCAAATTGTTGAACGTACACGTAAGGGTGGTGCAGAAATTGTTGCATTACTA720 GGTCAAGGCTCAGCATATTATGCACCAGCAACTGCTATATATGAAACTATAGATGCAATT780 TTTAATGATCGGAAACGGTTATTACCAAGTATTGCTTATCTAGAGGGAGAATACGGTTGT840 TCAGATATTTGTTTCGGAGTTCCTACTATAATAGGATATCAAGGAATAGAAAAGATTATA900 GAGGTAGATATGAATAATGATGAGTATCAACAACTACAACACTCTGCGCAAGATGTGAGT960 GAAGTCAAAAACTCACTAAAATTCAAATAAATAATTATGAAGTTCTACATCTTAAATTGT1020 TAGATTTTTGTGAAAATTGTGTAAAGGGTATTTTTTCGTTGATTTATAAAAGCGCTTTCT1080 TGATATAATGAACATATATTCATAGAATAAGGAGACGATTAAAATGGCTAAAGGGGACCA1140 ATATCAAGCTCATACTGAAAAATATCATGAGTAAAAAGTCTAAAAAAAGTTATAAACCTG1200 TGTGGATTATCATTAGTTTTATTATTTTAATTACAATCTTGTTATTACCCACACCAGCAG1260 GATTACCTGTAATGGCTAAAGCAGCACTAGCTATTTTAGCTTTCGCTGTAGTTATGTGGG1320 TTACAGAAGCAGTTACTTATCCAGTTTCTGCAACATTAATTTTAGGATTAATGATACTTT1380 TACTAGGTTTAAGTCCAGTTCAAGATTTATCCGAAAAACTTGGAAACCTAAAAGTGGCGA1440 CATAATACTAAAAGGTAGCGATATTTTAGGAACGAATAACGCGCTTAGTCACGCTTTTAG1500 TGGTTTTTCAACCTCAGCCGTAGCACTTGTAGCTGCAGCATTATTTTTAGCAGTAGCTAT1560 GCAGGAAACCAATTTACATAAACGACTTGCATTATTTGTGCTATCAATTGTTGGAAATAA1620 AACTAGAAATATAGTCATTGGTGCTATTTTAGTATCTATTGTTCTAGCATTCTTTGTACC1680 ATCAGCTACAGCACGTGCTGGTGCAGTTGTCCCAATATTACTGGGAATGATTGCTGCATT1740 TAATGTGAGTAAGGATAGTAGACTTGCTTCATTATTAATTATTACTGCTGTACAAGCAGT1800 TTCGATATGGAATATAGGTATTAAAAACGGCTGCAGCACAAAATATTGTAGCCATCAATT1860 TTATTAACCAAAATTTAGGACATGATGTATCATGGGGAGAGTGGTTTTTATATCTGCGCC1920 GTGGTCAATCATTATGTCTATAGCTCTTTATTTTATAATGATTAAGTTTATGCCACCTGA1980 ACATGATGCAATTGAAGGTGGAAAAGAGTTAATTAAAAAGGAACTTAATAAATTAGGACC2040 AGTCAGTCATAGAGAATGGCGACTAATTGTGATTTCAGTGCTTTTATATTCTCTGGTCGA2100 CTGAGAAAGTATTGCATCCGATTGATTCAGCTTCGATTACACTAGTTGCTCTAGGTATTA2160 TGCTAATGCCAAAGATTGGTGTTATTACTTGGAAAGGTGTTGAAAAGAAGATTCCTTGGG2220 GGACGATTATAGTATTTGGTGTAGGAATCTCACTTGGTAATGTATTACTTAAAACAGGAG2280 CCGCTCATGGTTAGTGATCAACATTTGTTTGATGGGTCTTAAACATTTACCGATCATAGC2340 AACTATTGCGTTAATTACCTTATTTAATATATTAATACATTTAGGTTTTGCAAGTGCAAC2400 GAGCTTAGCCTCTGCGTTAATACCTGTGTTTATTTCTTTGACTTCAACGCTAAATTTAGG2460 TGATCATGCTATTGGTTTTGTATTAATACAACAATTTGTGATTAGTTTTGGTTTCCTACT2520 ACCTGTCAGTGCACCACAAAATATGCTTGCATATGGTACTGGGACTTTTACCGTAAAGGA2580 TTTTTTAAAGACAGGTATACCTTTAACGATAGTAGGTTATATTTTAGTTATCGTATTTAG2640 TTTAACGTATTGGAAATGGCTTGGTTTAGTGTAAGTAAAAGATTTAGGTATTAAAATGAT2700 AATTATAAATGTCTCGTAAAGTTTAATATTTTAACTTTACGACACATTTTTTATAAACTC2760 GTGGCAAGTTAATCTTAATAGTTGAAATGTATCGTATAAAAAATATATGAATGTAAATAG2820 AATTTAGTATTAGAGAATAACAAAAAATTGATGTTAGGTGGTAAAATCTAATGGCTATAG2880 GTGTCATATTAAATAGAGTTTTTAGGCTAAATAATAATCCATTATTTGATTATATATATA2940 GTAATAAAGAATCTATAAATCATTGTTATTTTATTATTCCAACTGAAGAGTTTGAAGAAG3000 AAGCAAAAAAGAAAGCACAATACTATTATGGGTCCATACAGAAGTTTATGTATGAACTAC3060 AACGATATGATATAGAACCCTTTTTGATGTCTTATGATAAATTAATAGACTTTTGTAAAA3120 AACAAGCTATAGACAAAGTTGTTGTTGCAGGTGATATTATGAGTTATCATCACGAAGAAT3180 ATGACATTTTACATCAAAGGAAACGATTTAAACAAGCTAATATTCAAGTAATATCATTAA3240 GAGCAAATCATTATTTTAACCCCCGCAAAACACATAATAAACAAGGGGAACCATATAAAG3300 TATTTACCAGTTTTTATAGAAAATGGCGTCCTTACTTAATGATTAGAGATGAATATGACT3360 ATCATTTAGAAGATATTTCAAAGGTTGTAGTGAAATCTCAACATAAAATTAAAGAAGATT3420 ATCATTCATATGGTATAAGTGAACGTGATGTTCAAAATCGTTGGTCTGAATTTTTATCTC3480 AAGATATCGAAAATTATAAAGAAAACAGGGAATACTTGCCTGAAGTATTAACAAGCCAAC3540 TAAGTATTTACTTAGCTTATGGAATGATAGATATTATACAATGTTTTCAACGATTTACTT3600 CAAAATTATGATAAAAATGAACAAAATTACGAAACTTTTATACGTGAATTGATTTTTAGA3660 GAGTTTTATTATGTATTAATGACCAATTATCCCGAAACAGCTCATGTTGCTTTTAAAGAA3720 AAATACCAACAATTGAAATGGTCTTATAATGAAGAGAATTTTAAACTGTGGAAAGATGGG3780 AATACTGGTTTTCCAATTATTGATGCAGCAATGGAGGAACTTAAAACAACTGGATTTATG3840 CATAATCGCATGAGAATGGTAGTTTCTCAATTTTTAACTAAAGATTTGTTTATTGACTGG3900 ATTTGGGGTGAGTCATTTTTCAAACAAAAATTAATAGATTATGATGCAGCTTCAAATGTT3960 CACGGATGGCAGTGGTCAGCTTCTACTGGAACAGATGCTGTACCATACTTTAGAATGTTT4020 AATCCTATAAGACAAAGCGAGCGTTTTGATAATAATGCACGATATATAAAAACTTACATT4080 CCAAGATTAAATCAGGTAGATGCTAAGTATTTACACGATACTCATAAATTCGAGCAACAA4140 ATAAAGGGGCAAGGTGTTGAAATAGGTAAAGACTATCCTAAACAAATGATTGATCACAAA4200 GAAAGTAGACAACGTGTAATGTCAGAATTCAAAGCTATAGATTAAATAAAAAAGATCTGA4260 ACAACATGATATAGGTGTTCAGATCTTTATCTAGTTACATAAAAAAGCAAACATGAATTA4320 AAATATATTCTAACAAAGTTAAAATATACATATATTTAAGATTTAATTTAGTTTTCAAAG4380 GTACTTCCCAATTTGTATAACGGGGCTCATAATAAAATAATTGCATCAAATATAATCCTA4440 TCCCTAACGGTAAACACATTAATAAAATAGCTTTAGTATAACTCCATCCTATTTGATGCC4500 ATAAATGACCTATCATAAGTTGAATAATGATGAGACATACCATTAAAATTACTTCAATTA4560 TCATTGGTATAATCTCACCCCTTTAATAAACAATATGACTGTTGCTTGTATGAGCACCAT4620 TAAAACGACAAATAGTAACGCTTTAACATCTATGATTAAAAAAACCTCTTTCACAATTTT4680 TAAAGGTGCATTTAATAAATAGACAGTATGTAATCTTAAGAATCGACCGATGTAAATACC4740 TAATCCATTTAAGAACATTAATATAACTATCAATAGTCGATTTAACCATACATAAGACGT4800 AAAATGTGCAATTTCTAAAAATATAAGAATTGTGAGGTATATTGCTAAGAGTACGCCAAG4860 TATTAAATAGGTGAAATAAATCCATTCTGTGATGTTTAATCCAGCTAAAAAGTTAAATTG4920 AAATTGGTTTAAGTGTATGAGATCGGTAATCATATAAAATGTGTTTGGAACTAATAATAG4980 AAATATGAGTCCGAAAACAATAAATAAGGGCCATTCAAAAGCTT5024 (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3287 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus epidermidis (B) STRAIN: Clinical Isolate SE- 37 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: AAGCTTGCCTATTGATTTTAAAAAATTAATGATTATAGGTTCACTCATATCTGTTGCAAC60 TGCATCAGTGCCTATGTTTTTTGGGAAGCCATTTTTATATCAAACTGAAGCAAATGTAAC120 ATTTCCATTACTAGGACATGTTCATGTTACTACTGTGACTTTATTTGAGCTTGGCATCTT180 ATTAACAGTAGTAGGTGTGATTGTTACAGTTATGCTATCTATAAGTGGGGGTAGATCATG240 AATTTAATATTACTCCTTGTGATAGGATTTTTAGTGTTTATTGGAACTTATATGATTTTA300 TCTATTAATTTAATTCGTATTGTTATTGGTATTTCTATTTATACACACGCCGGTAATTTA360 ATTATTATGAGTATGGGGAAATATGGACCTCATATGTCTGAACCGCTAATTCAAGGTCAT420 GCTCAAAACTTTTGTTGATCCTTTATTACAAGCTATCGTTTTAACAGCTATTGTGATTGG480 ATTTGGTATGACTGCGTTTTTATTGGTGTTAATATATAGAACTTACAGAGTAACTAAAGA540 GGATGAAATAAGTGCATTGAAAGGTGATGAAGATGATGAGTAATTTAATAATATTGCCTA600 TGTTGTTGCCTTTTGTATGTGCTTTAATTTTAGTCTTCACTAAAAATAAAAATCGTATTT660 CGAAAATCCTATCCATTACAACTATGATTGTTAATACAATGATTTCAATTGCTTTACTTA720 TTTATGTCGTTAATCATAAACCGATAACACTTGATTTTTGGGGGGATGGAAAGCACCTTT780 CGGCATTCAATTTCTAGGTGATTCACTGAGTCTGCTTATGGTGTCAGTATCATCTTTTGT840 TGTTACGCTAATAATGGCATACGGCTTTGGTAGAGGGGAGAAGCGAGTCAATCGATTCAC900 CTCCTACATTATCTTTATTAACAGTAGGTGTTATTGGTTCGTTTTTAACTTCTGATTTAT960 TTAACCTATACGTGATGTTTGAAATTATGCTTCTTGCTTCGTTTGTACTTGTTACATTAG1020 GACAATCTGTTGAACAATTACGTGCAGCGATAGTATATGTTGTTCTGAATATTTTAGGTT1080 CGTGGTTGCTTTTATTAGGAATTGGCATGTTATATAAGACAGTCGGAACACTTAATTTCT1140 CACATTTAGCGATGCGATTGAATCATATGGAAAATAACCAAACAATAACGATGATATCTT1200 TAGTATTTCTAGTTGCTTTTAGTTCAAAGGCAGCACTAGTGATTTTCATGTGGTTACCTA1260 AAGCATATGCAGTGCTTAATACGGAACTTGCCGCGTTATTTGCAGCATTGATGACAAAAG1320 TTGGAGCTTATRCGCTTATTCGTTTTTTTACTTTACTATTCGACCATCATCCAAGCGTCA1380 CGCATACATTGCTCGTGTTTATGGCTTGTATCACAATGATTATCGGTGCATTTGGTGTCA1440 TCGCTTACAAAGATATTAAGAAAATTGCGGCTTATCAAGTTATTTTGTCTATTGGATTCA1500 TTATTTTAGGTTTAGGTTCTCATACTATATCAGGTGTAAATGGTGCTATCTTCTATTTAG1560 CGAATGATATTATCGTTAAGACATTATTGTTTTTTGTAATTGGTAGTCTTGTTTATATGT1620 CAGGCTATCGAAATTATCAGTATTTAAGTGGACTGGCAAAAGAGAACCATTCTTTGGTGT1680 TGCATTTGTCGTGGTAATTTTTGCTATAGGTGGCGTACCTCCTTTTAGTGGCTTTCCGGG1740 TAAAGTCTTAATATTCCAAGGGGCTATTACAAATGGTAATTATATTGGTTTAGCACTTAT1800 GATTGTGACAAGTTTAATTGCTATGTATAGTCTTTTTAGAGTGATGTTTATAATGTATTT1860 TGGTGATGCTGACGGAGAACAAGTACAATTTAGACCACTACCTATTTATCGTAAAGGTTT1920 ACTTAGTGTTTTAGTTGTAGTGGTATTAGCGATGGGTATTGCAGCCCCTGTTGTTCTGAA1980 AGTAACAGAGGATGCAACAAATCTTAATATGAAAGAAGATGTCTTTCAAAAGAATGTAAA2040 TACACATTTGAAGGAGGTTAATCATAAGTGAAGCAAGTTGTATTAAATATTGTTATCGCG2100 TTCCTTTGGGTACCCTTTCAAGATGAAGATGAATTTAAATTTACAACCTTCTTTGCTGGA2160 TTTTTAATTGGTTTAATTGTGATTTATATTCTGCATCGCTTTTTTGGTGAAGAATTTTAT2220 TTGAAAAAGATATGGGTGGCTATTAAATTTTTAGCTGTATACCTATACCAGCTTATTACT2280 TCTAGTATAAGTACCATAAATTACATCTTATTTAAGACGAATGAAGTTAATCCAGGTTTA2340 CTCACATATGAAACTTCATTAAAAAGTAATTGGGCTATTACTTTTTTAACGATTTTAATT2400 ATTATTACTCCAGGATCGACAGTTATTCGAATTTCTAAAAATACTAATAAATTTTTTATT2460 CACAGTATTGATGTGTCAGAAAAAGATAAAGAAAATCTTCTAAAAAGTATTAAGCAGTAT2520 GAGGATTTAATTTTGGAGGTGACACGATGATTGAAATGTTCACTCAAATATTTATTATAA2580 GTGCATTAGTGATTTTTGGTATGGCACTACTTGTTTGTCTAGTCAGATTAATTAAAGGTC2640 CCACTACTGCTGATAGAGTTGTATCATTTGATGCCTCGAGTGCTGTTGTTATGTCTATTG2700 TTGGTGTGATGAGCGTTATTTTTAACTCAGTGTCTTAATGTTAATTGCAATTATTTCGTT2760 TGTCAGTTCGGTCTCAATTTCAAGATTCATCGGGGAAGGACGTGTCTTCAATGGAAATCA2820 TAAAAGACATCGTTAGTCTTATTGCTTCGATACTTATTTTCTTAGGAAGTATTATTGCAT2880 TAATTAGTGCAATAGGGATTGTAAAATTTCAAGATGTCTTTCTAAGAAGTCACGCCTCAA2940 CGAAAAGTTCTACATTGTCAGTATTACTAACTGTAGTTGGTGTACTGATCTATTTTATTG3000 TGAATTCAGGTTTTTTCAGTGTCAGATTATTATTATCACTAGTTTTTATCAATCTTACAT3060 CTCCGGTTGGAATGCATTTGATAAGTAGAGCGGCCTACCGTAATGGTGCATATATGTACA3120 GGAAAGACGATGCATCTAGACAATCTACTATCTTATTAAGCCAAAAAGAGTTTAATACGC3180 CAGAAGAATTAAAAAAACGTGCAAAACTACGAGAAGAAAGACGAGAAAAATTATACTATA3240 AAGAAAAAGAATATATTAATAAAATGGACGATTGATTGTTTAAGCTT3287 (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2291 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Staphylococcus faecalis (B) STRAIN: Clinical Isolate S2- 1 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: AAGCTTTAGATAATGATAAACGCGTGTATGTGAATGTCCAGCCGATTCAATCGCCTACTG60 GAGAAACAGTGATTGGTGTCCTTTATGTGAAAAGTAATTTAGAAAATAAATACCAAGAAA120 TTACTAACACAGCAAGTATCTTTTTCACTGCTTCTATTATTGCCGCAGCAATCTCGATTA180 TTGTGACCCTACTGATTGCACGATCAATCACGAAGCCGATTGGTGAAATGCGCGAGCAAG240 CCATTCGAATCGCTCGTGGTGATTACGCTGGAAAAGTAGAAGTCCATGGAAAAGATGAAT300 TAGGCCAATTAGCAGAAACATTTAATCAATTATCAGAACGGATTGAAGAAGCACAAGAAA360 CAATGGAAGCAGAAGAATCGTTTAGATAGTGTCTTAACGCATATGACAGATGGTGTCATT420 GCGACGGATCGCCGCGGAAAGGTGATTACGATTAATGAGATGGCCCTTTCATTATTAAAT480 GTAAAAAATGAAAATGTGATTGGGACCTCGTTATTAGAGTTGTTAGATATTGAAGAAGAT540 TACACATTGCGGAAGCTGTTAGAAGAGCCAGATGAACTGCTGATTGATCGCTCAACGTCT600 GATCGTGAAGAAGACCAAATGATTATCCGGGTAGACTTTACGATGATTCGTCGGGAATCA660 GGATTTATTACTGGCTTAGTTTGCGTACTTCATGACGTCACAGAACAGGAAAAAAACGAA720 CGGGAAAGACGGGAATTTGTTTCCAATGTTTCTCATGAGTTGCGACGCCTTTGACAAGTA780 TGCGTAGTTATATAGAGGCTTTGAGTGAAGGAGCTTGGGAAAACCCTGAGATTGCGCCGA840 ATTTCTTAAAAGTCACGTTAGAAGAAACCGACCGGATGATTCGTATGATTAATGATTTGT900 TAAATTTATCTCGGATGGACTCTGGGAATACACATCTTCAATTAGAGTATGTGAATTTTA960 ACGAATTGATTAATTTTGTCTTGGATCGCTTTGATATGATGATTGAAAATGAGCAAAAAA1020 ATTACAAAATTCGCCGTGAATTTACTAAACGCGATTTATGGGTAGAGTTAGATACAGACA1080 AAGTAATTCAGGTTTTTGACAACATTTTGAACAATGCGATTAAGTATTCGCCAGATGGCG1140 GCGTCATTACCTGCCGACTAGTTGAAACACATAATAATGTCGTCTTTAGTATCTCGGACC1200 AAGGTTTGGGCATCCCTAAAAAAGATCTCGGGAAAGTCTTCGAGCGTTTTTATCGTGTGG1260 ATAAAGCACGTGCGCGAGCACAAGGTGGGACTGGTTTAGGTTTAGCAATTTCTAAAGAAG1320 TAATTCGGGCCCATAACGGGAGTATTTGGGTGGAAAGTACAGAAGGTGAAGGATCAACTT1380 TCTATATTTCACTACCATATGAACCTTATGAAGAGGATTGGTGGGAATGATGAAAAAATC1440 AGAATGGATTACAAGAATTGGCTTGATTTTGATGGTCATTTTAAGTATATATTTTTCAGT1500 CAATATCTGGCTGAATTCTGCCAAAAAAATACCAGAAATGAAGTCGGGAAGCCAAGTCAC1560 AACAGCTGTCAATGAAAAAGCCATTGGCGATGTCTATTTACCTTTGCAATTGATTCGAAT1620 AGCCGATGGAAAAGCGATGCAAAGTAATCGTGAAACATTAATTAGTAATGTTCAAAATGA1680 TATTAAAATGGCTACGTTTGGTAAATTGACACAAGTTGTGACAAAAAATGCAGAGCAACT1740 TAAGCGCTACAACCAAATGGAACAAGGCATTGAACTTCTTTATCAAGGTCCCTTTTTAAT1800 CTCGGACTATGCTTCGATTTATAATCTATCCATTAATTTTACTAACTTTAATGAGTTGAC1860 GGACCAGTATTTTACGAAAATTCAATTGGATTTTAACGAAAATAAGATACGTTTTTTAGA1920 TTATGATCAATCCAACGTCTATGAAGCGCCCATGACTGTTAATAAGGCGCGCTTAATGGG1980 AATTATCAATAAAGAGGGATTGCAATATCAAGACGTTTCCGAAAATACGCTAACCAAACA2040 AGGACAATGTTATTTAACCAATGATATGAAGTTGAAAAAGTACAGTTATATCTTANTTCG2100 CAACCAGTTACTCGTTTTAGGAATGCTTTTTTCAATGAAACGGAAGATATCCAAACCAAT2160 GAAGACAGTCAAGACTTAACCTATACGAGTAAAGAAGAACGATTGTTTGCAGAAGAAAAA2220 CTGGGGAAAATCGATTTTAAAGGGACCTTGCCAGAAGAGAATAAACGGGACTCAATCTAT2280 AATCAAAGCTT2291 (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3719 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Enterococcus faecalis (B) STRAIN: Clinical Isolate S2- 3 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: AAGCTTCATTAGAGCGTCAACTGTTTTTGGTGTTGGGTTCACAATGTCAATTAGACGTTT60 GTGAGTACGCATTTCGAATTGTTCGCGAGAATCTTTGTATTTATGAGTCGCACGAATAAC120 TGTGTAAAGTGAGCGTTCTGTTGGTAATGGAATCGGACCTGATACGTCAGCTCCAGTTCT180 TTTTGCTGTTTCCACAATTTTATCCGCTGATTGATCTAAAATACGGTGTTCATACGCTTT240 TAAACGGATACGAATTTTTTGTTTTGCCATCTTGTTCCCTCCTTCGCCTATTTTAAAAGT300 AGACATAGCTCCACGAAAATTTATCCGGCATGCTCGTTCATGGCAAAGCGTCCGAGCGTG360 TCGCAACCTCTCGCTTCACAGCCGGCAAATCAAATCGTTGATCTACCAATGCTTTTTACA420 CTCCTGTAAACAGCACCTTTTTGATTATACTATGAAAGGATAGTGTTAGCAAGGATTTTC480 TGCGTTTTTTTAAAAGAATTTTTTCTTGTTTTGAAAAGCATTTGTTTTGTTTTTCAATTC540 TTTTCATTCTATTTTTATAAAAAAAGAATTTGAGATTCTTTTTTTACCAGAATCTCAAAT600 TCTTTCTTTTTTATTCTATTAACCAATCCGGCGCATTGGAATATCATTGTTATCTGGATG660 AACCAATAAATATTGAATAACATCAATATTGCTTGCTTGGAATGAGGCTGCACATGCTTG720 CAAATATAAGTCCCACATTCGATAGAAGCGCTCGCCTTTTTCGTCAACAATTTCTGTTTC780 TATATTATGGAAGTTTTTTGTCCAATGTTCCAACGTCAATTGATAATCTCTGCGCAAACT840 TTCCAAGTCAATCACTTGCAAGTCGTTTTCTGTCATATGGCCGACTAGCTCAGTGACACC900 AGGAATATAGCCACCTGGGAAAATATAACGATTAATCCAAGCATTTTTAGCCCCACCTTG960 TTGGCGACTGATCCCATGAATCAACGCCGTACCTTTAGGCGCTAAATTTCGCTGAACGAC1020 ATCAAAATATTCATGTAGATTTTCCGCACCGACATGTTCAAACATCCCAACACTCGTAAT1080 ATGGTCAAAAGACTCTCCTTTTAAATCACGATAATCCATCAATTTGACAGTCATTCGATC1140 TTGTAGACCTTCTTTTTCTATAATATGGCGAATATGATGAAATTGCTCTTCACTTAATGT1200 AATCCCAGTTGCTTTGGCTCCATATTCTTTCACCGCAGTTAAAATTAACGTGCCCCAGCC1260 GCAGCCAATATCCAGTAAAGTGTCGCCCTCTTTGATAAACAATTTATCTAAAATATGATG1320 AACTTTATTCACTTGCGCTTGTTCTAATGTATCTTCAGGCGTTTTAAAATAAGCACATGA1380 ATACGTCATTGTTTGGTCAAGCCATTTTTTGTAAAAATCATTTCCTAGATCGTAATGGCT1440 GTGAATATCCTCTTGCGAACGTTTTTTTGAATGACTTTCTTTAGGAAGCCATTTAATAAA1500 TTTAGCATTGTGTAAAAAGCTATCCTTTTGGTTATACACATCATAAATCAGCGCTTGGAT1560 ATCGCCTTCGATTTCAATTTTGCGATCCATGTAGGCTTCCCCTAAAGTTAACGAAGCGTT1620 ATTCAGTAAATCCTTCACAGGAATTTTTTCATTGAATACAATTTTAAAAACCGGATCCCC1680 CGACCCTTGCCCATACTCTTTGACGGTACCATCCCAGTATGTGACTTGTGTCTTTTTTGA1740 AAAAGACCATTTAAACAGTTGACTGTACGTTTCTTTTTCTAACATTGCATTCCCTCCATT1800 AAATACCATTTGAAGCCAAAACAAAAAGAAGTCGCTTTCCGGTAGTTCGTCAAAACAAAC1860 ACCACAGTCCGTTCTAAACTGAAGCACAGAAAAGTTATCACCCCTTCTATGTTCCGCTTC1920 TTTTTTGCAATTACAGTTCTATTCTACTCCTCTTTTAAAAATTTGAACATTCTTTTAACG1980 TAATACCTACTATTGTTATTCTTTATCACAAAAAAACTAGAGCCAGTCCTTGACAGACTC2040 CTCTAGTTCTAAATATTATGCTTTCTTACGCATCCGTTGTTCCGCATGAGTGTAAGCGCC2100 ATGCCACACGTGCCCCACATAAGGATTAACTTGAATACCGTGTTTAATCGCCGCTGCTAC2160 AAATTTTTCGCTAAAGTTACTGCTTCTAACACCGAATAACCTTTCGCCAAGCCAGCTGTG2220 ATTGCCGCTGAAAAAGTACAACCTGCACCATGATTATAATCAGTTGGATATAATTCATTT2280 TCCAAAAGATGCGCGGTGTGACCATCGTAAAATAAGTCCAGTGCTTTTTCACCAGCTAAG2340 CGATGTCCCCCTTTAACCACGACATGCTTGGCTCCCATTTGTACAATTCGTTTTGCCGCT2400 TCTTCCATCTCCGCCACGGAAGAAATTTCGCCTAAACCAGATAAGATGCCCGCTTCAATT2460 AAATTAGGCGTGGCAACTAATGCTAATGGCAGTAAATCGTTTTTAGGCCTTCCACACTTT2520 TGGGTTGCAGAATTTGTGCCGTTCCCTTACAAGCAATGACTGGGTCAATCACGACTTTTT2580 GAATTTTTTCTTGTTTAATGTACTTACTAGCCATTTTAATATTTTGTTCATTACCCCATC2640 ATCCCCTGTTTTCAAAGCCGCTACTGGACCGCCTGCAAAAACCGAAATCAATTGTTTTTC2700 TAAGAGCGTTTCTGGCAATTCAGTTACTTCATGTGACCAACCTGTCGTAGGATCCATCGT2760 CACAATCGAGGTTAAACTTGAAAATCCAAAAACTCCATACTCTTCAAATGTTTTTAAATC2820 TGCTTGAATCCCTGCCCCTCCAGTTGAATCGGAGCCTGCAATCGTCAATACTTTTTCCAT2880 TAAATCACCTAACCTTTTTCTCCAAGTATACGGAAGAAACAAGTCTGCTAAAACAGCCAA2940 TTGGCTTATTTTTTAGCCAGCCAATTTCTAAACAAAAAAAAGACCAGAGAATAAATTCTC3000 TGGTCTTACGTCCGAATACCCCAGTTTTTCACGCTGGTTAAAGCTATAGTTAAAAAGTTA3060 ATTATTTAACGATTTCAGTAACAACGCCTGAACCTACAGTACGTCCGCCTTCACGAATAG3120 AGAAACGAGTTCCGTCTTCGATAGCGATTGGGTGAATTAATTCAACGTCCATAGCAACGT3180 TATCACCAGGCATTACCATTTCAGTACCTTCTGGCAATTCTACAACACCAGTAACGTCTG3240 TTGTACGGAAGTAGAATTGAGGACGATAGTTAGTGAAGAATGAGTGTGACGTCCGCCCTC3300 TTCTTTTGATAATACGTATACTTCAGCTTTGAATTTTGTGTGTGGAGTGATTGTAGCTGG3360 TTTAGCTAATACTTGTCCACGTTCGATATCTTCACGTGCAACACCACGTAATAAAGCACC3420 GATGTTGTCGCCTGCTTCAGCGTAGTCTAATAATTTACGGAACATTTCAACACCTGTAAC3480 AGTTGTTTTAGATGTTTCGTCTTTAATACCAACGATTTCAACTTCGTCACCAACGCGAAC3540 TTCACCACGTTCAACACGGCCTGTAGCAACAGTACCACGTCCAGTGATTGAGAATACGTC3600 TTCGACTGGCATCATGAATGGTTTGTCAGTATCACGTTCTGGAGTTGGGATATATTCGTC3660 AACTGCAGCCATTAATTCTAAGATTTTTTCTTCATAAGACTCGTCGCCTTCTAAAGCTT3719 (2) INFORMATION FOR SEQ ID NO:11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3480 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Enterococcus faecalis (B) STRAIN: Clinical Isolate S2- 7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: AAGCTTCTAGCGTTTCGGATTGGCGCCTATGATGCACCAGGAGAGCGACGAATCAATACC60 AAAAATATGCCTACAGCAGGAGGACTTGCAATCTACATTGCTTTTGCTAGTTCATGTTTA120 TTGATTTTTCGTTCGATTATCCCACAAGATTATATTTGGCCGATTATTTTGGCTGGTGGA180 ATGGTTGTTTTGACAGGCCTCATTGATGATATTAAAGAGATTACTCCAATGAAAAAAACA240 ATCGGTATTTTGTTAGCAGCATTAGTTATTTTATTTTGTTGCTGGAATTCGGATAGATTT300 TGTGACGTTGCCAGTTGTTGGAATGATTGATTTGCGCTGGTTTAGTTTACCACTAACTTT360 ATTGTGGATTTTAGCGATTACGAATGCAGTAAATTTAATTGATGGTTTGGATGGTTTAGC420 ATCAGGCGTATCCATTATTGGATTAACCACGATTGGTATTACAGGGTATTTTTTCCTACA480 TGCTAAAACGGTCTATATCCCAATTGTTATTTTTATTTTAGTTGCGAGCATTGCGGGATT540 TTTCCCATACAATTTTTATCCGGCTAAAATATTTCTAGGAGATACCGGGGCGTTATTCCT600 CGGGTTTATGATTGCAGTAATGTCGTTACAGGGCTTGAAAAATGCTACGTTTATTACGGT660 AATTACGCCAATGGTGATTTTAGGTGTGCAATTACGGATACGGTTTATGCAATTATTCGA720 CGGCTATTGAACAAGAAGCCCATTTCCTCAGCAGATAAAATGCATTTACATCACCGCTTG780 TTATCTTTAGGTTTTACCCATAAAGGGGCGGTCATGACTATTTATGCATTAGCGTTAGTT840 TTTTCCTTTGTCTCTTTATTGTTCAGCTATTCAAGTACAGTAGCATCAATTTTATTAATT900 GTCTTTTGTTTAATTGGCTTAGAACTATTCATTGAACTAATCGGTCTAGTTGGCGAAGGG960 CATCAACCGTTGATGTATTTGTTACGGATTTTAGGGAATCGTGAATATCGTCAGGAGCAA1020 ATGAAAAAGCGACTTGGCAAGCATTCTAAGAGAAAGTAAAGAAATCTTTAGGTTGCTTTG1080 CGAGAGCTAAACCTATGATATAATTCCATTAAACTTAAAAAAGTATATGTGTGAAACATA1140 TGCTTTTTTTTTAAGACGATGTTTCAGTAGTAAGGAGAAATGAGCATGCAAGAAATGGTA1200 ACAATCTCGATTGTCACTTATAATAGTCGTTACATTTTTAATGTACTAGACCAATTAAAA1260 GCCGAACTAGGTACTGATAGTATCTATGATATTCATATCTATGACAATCATTCTGAAACA1320 GCGTATCTTGAAAAATTAACAACATATGAACCATTTATTACTATCCATCGCGCTGAAGAA1380 AATCAAGGGTTTGGTCATGGTCATAATCAAGTGTTATTCAATGCTTCGACAAAGTATGCA1440 ATTATTTTTATCCCGATGTGTTGGTTACTAAAGACGTGCTTGATCGTTATTAGACGTATC1500 AAATAGATAAGAACATTGCAGTCGGTAGCCCTAAAGTTGTTAAATGAAGATGGCACGACG1560 CAATATTTAGTTCGTCAAAAATTAGATGTCTTCGATTATATGTTACGTTTTATTCCCTTT1620 CAATTTGTAAAGAAAATTTTTGATAAACGTTTGAGTATTTATGAATGTCGCGATTTGTCG1680 GATACAGAAACAACGGATATTAAAATGGGCTCAGGCTGTTTTATGTTGATTGATCGTGAA1740 AAATTCGTTGAAATTGGTGGGTTCGATGAACGTTTCTTCATGTACTTTGAAGACAACGAT1800 TTATGTTTACGCTTTGGCAAAGCAGGCTATCGGATTCTCTATACGCCTTTTGAAACGGTT1860 GTTCACATGTATGAAAAGGGCGCCCATAAAAGTCGAAAATTGTTTAAAATCTTTATGCAA1920 TCAATGGGGAAATTTTTTAACAAATGGGGCTGGAGGTTCTTTTAATGAGTCAAAGATTAG1980 CGGTAGTCATCGTCTTATATCAAATGAAAATGGCTGATACGCCGAATTATTTGTTATTAA2040 AAGAAGTGGTAGACCACCCCCAATTGCACTTATTTATTTATGACAACAGTCCACTTCCTC2100 AAGAAGATGCATTATTTTTACAACCAAATGTTACTTATCGACATAATCCTGATAATCCAG2160 GACTAGCGACCGCTTATAATGAAGCGATTGCTTTTAGTCAAGCGAATCAATGTGAATTAT2220 TGTTGCTCCTTGACCAAGACACAGAAGTGCCAGCCTCTTATTTTGATACGTTGATCATCA2280 TGCCATTAGATCCGACTGTGGCAGTCTATGTTCCAATTGTAGAAGCAAATGGACAACAAA2340 TTTCGCCAGTATATAGTGATCAATACGTTGGGCTTAAAGGAGCAAAGCCAACAGCAGGGA2400 TAGCCAACCAACCGTTGATGGCTATCAATTCTGGTACAGTTATTACGGCAGAAACGCTAC2460 GCTGGTTGGAAGGATTTTCGGAAGAATTTCCTTTGGACTATTTAGACCATTGGTTCTTTT2520 ATCAATTAAATCAAGCCAATAAAAAGATTGAAGTCTTACCAATCCACCTAAAACAAGAAT2580 TGTCTGTTTTAGATTATCGTACAATGAGTCCTCAACGTTATCGCTCTATTATTGAAGCAG2640 AAACGTTATTTTATCGTCGATATGATCAAGAAAAGTTTTCCCATCATCGACGCCATTTAT2700 TTTTACGCAGTAGTAAGCAATTTTTAACTGTCAAAAATCGCCAAATTTGGCGGCAAACAT2760 TGGCAGAATTTCTCAAGTTAATGAAAGGATAATCTATGATCTCAGTTTGTATTGCGACAT2820 ATAATGGAGAAAAATATCTCGCGGAACAATTAGATAGTATTCTTTTACAAGTCAGTGAAG2880 AAGATGAACTAATTATTTCAGATGATGGTTCTACTGATCATACGTTGGAAATTTTGAGGA2940 CGTATGCAGCGAATTATCCCCAAATTCAATTGTTACAAGGTCCCAGGGCAAGGAGTGATT3000 GCTAATTTTGCATTTTGCCTTACGCATACGAAAGGCGAAGTAATATTTTTAGCAGATCAA3060 GATGATGTTTGGTTGCCAAATAAAGTAACGACGGTGACAGAATATTTTGAAGCGCACCCT3120 GACATCCAAGTGGTTATTAGTGACTTGAAAATTGTTGATGCGGATTTACAAGTTACCAAT3180 CCCTCTTATTTAAGTTTCGAAAAGTCAAACCAGGGTTTTGGCGAAATGCGATAAAAAGTG3240 GCTATATTGGGGCAGGTATGGCCTTTCGTCAAGAAATGAAAAACGTCATTTTACCCATTC3300 CGCCAGAAGTTCCTATGCATGATATGTGGATTGGCTTATTAGCTGCACGGAAGAAGCAAA3360 CGGGTCTCATTAAAGAACCATTAGTGCTTTACCGAAGACATGGAGCGAATGTCAGCCCCA3420 TTATTACCAAAACAAGTTTCCAACAAAAATTAAATTGGCGTGTGAATTTATTAAAAGCTT3480 (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2441 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Enterococcus faecalis (B) STRAIN: Clinical Isolate S2- 27 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: AAGCTTCTGCGCTAGGAACCAGCCCTTTAATTACATCTCCCCATACTGGATTTGACAATG60 CCACTTGATAAGCAAAAATCACAAAAATAACAACAATTAAAGCAACAACAATAGCTTCAA120 TTTTTCTAAAACCAATTTTTGTCAATAACAACAAAAGTAAAACATCAAATACCGTAATGA180 AGACAGCCAGACCTAAAGGAATATGAAATAATAAATATAAGGCAATTGCGCCCCCGATAA240 CTTCAGCGATATCTGTAGCCATAATTGCTAACTCTGTTAAAATCCATAATACAATACCTA300 ACGTCTTACTAGTTCTAGCACGAATCGCTTGTGCTAAATCCATCTGTGAACAATGCCTAA360 TTTAGCAGCCATATATTGGAGCAACATTGCAATCAAACTGGAAATTAAAATAATCGACAT420 CAATAAATATTGAAAATTTTGTCCCCCAGTAATTGAAGTAGACCAGTTTCCTGGATCCAT480 ATACCCCACTGCTACCAATGCTCCTGGACCTGAGTAAGCAAATAACGTTTTCCAAAAACT540 CATATTTTTAGGCACGTCGATGGTGCCATTAATTTCTTCAAGCGAAGGACCATTTGCATA600 TTCAATCAAATGATGTCTTTGCTTTGGTTCATGTTCTTCTGAATTTTTCAATTCAATTCC660 TTCTTTCGTTTTGCAATAATTTTAAAAGGCCCTTCCCGTTAGAAGGTTAACCTCTAGTAT720 ATTTTAGGTACACCTAAAATATACTGCTAAAAATAACAAAATGCAAGACTTGAAAGAAAA780 TTTTGACAGTGTAAAAATAGATTGTCGTAAATGTGCGATCTTAAAGTTTGAAGAAATCAG840 GGTAGCTGGTAGTTGATTATCTTAAGAAGTAGAAAATAAGGGACCTAAGTCATTTCGGCT900 TAGGTCCCTTATTTTATTTTTATTCGGTTATTCTATTAAGAATGGATGCTACAATTTCTG960 TCGTGTCAGCTGAATGATTTCTAAAATCTCGTAAACTTAATCTGACGAAAACCTTCAAGT1020 ACTTCGGGCAACTTATTTTNCCCCCATTCAAAAGTTCCATCATTTCTTTTCAATAATCTT1080 TGTAAAATTTCTTCTTTCTCGACCGCTAACAAAAAATGATAAACGTCAATGCCTGCTCGT1140 CTCAGATATCCAATCAGCTCTTCTTCATATTCATTTTTATAAAGGGTCATTGTAACAATA1200 ATCGGCCGTCCAGACTCTTTGGACATTCGTTTTAATAAATGAGCATTCCAGCAACGCCAT1260 TCCTGATACTCCTGAAAATCATTTTCTTTCATTTCTTCGGGAACTAGCTCCATCAATGCA1320 CTACCAATAATTTCTGGATCATAAATGATTGCGTTGGGAAGTTTTTGTTGTAACTCATGT1380 GCAATGGTCGTTTTTCCGGATCCAAACGCACCGTTTAACCAAATAATTATCATAATTTCC1440 TTTTCTTCTGAACAAATTTCTTTGTTGTTTAATTTAGGTGCTAGATTACTTTTAATTTTT1500 TTAGCCATTCACTTATAGTTACTACTTACATCTTTAACAGTAAACGAGACAAACTAAAAA1560 TACAACATCCTACGCTATTAACCTCGGGTTATATAACATACTCATCTGATAATTTCTCCC1620 TAAAAAAACAGAATGTGGGCAATCTTTTTAAGAATAATTGAATAGAATAACAACAAACAG1680 TAATTCAGGTATAACCAGCTAGAAATTGTTTTATTTTTAGTCACGAGTATGATAAGCATG1740 TAAATCAAATAGAATCATATTAGGTGAGGTTACTCTGAAGAACACAGGTTATCGCTCGGA1800 AATGTCGAGAGACAGTAACGAGTAAAGCAGGGATTGTCGAATTAAGGCTTTCCTAAGATA1860 ACTAGAATTTTTTTCTTACGTCTCAGAAAGCCAAAGCTCAATTATTGTGATTACCCTATA1920 ATCTTCTTCTTTTATTCGGCGACCTCTTTAATATGATTAATTGGAGGTTTTTAAATTGAA1980 AGCTGTCACTGCATCATCTAAGAAAAATACCCTACTTGCTAAAAGTATCGGGAATCTTAC2040 CTTGCTCATCATTTTAGGCATTTTCATTTTTATCATCGTCTTCTCTTGGCTAAAAATGAA2100 TCGCCCTCTCCACACCCTTCCCTCAGAAGAATTCCTCGCAACACCAAGTAAAACAGATGA2160 TTTCTTATCTCCATCAAATCTTTTTTACTTTTCAATTCGAACCATGTTTCGAATGATTGT2220 GGGGATGGCTTGGTCCTTCCTGTTTTCCTTTGTTTTTGGTATTTTAGCCGTAAAATATAA2280 AACGGCACGAAGAGTCATTTTACCATTAGTTAATTTCCTTGAATCTGTTCCATTGCTAGG2340 TTTTTTGACCTTTACAACTGCTTGGTTACTTGGTTTATTTCCAGGAAATGTGATGGGCGC2400 AGAAGCGGTTGCTATTTTTGCCATCTTCACAGGTCAAGCTT2441 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9515 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Pseudomonas aeruginosa (B) STRAIN: Clinical Isolate P2- 2 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: AAGCTTTCCTCCAGACCCTTCACCGCCGTGGAGATCGACGGCTGGGCGATGTACAGCTTG60 CGCGAGGCCTCGGCCACGCTGCCGCATTCCACGGTGGTCACGAAATACTTGAGTTGCCGC120 AAGGTATAGGACGCCACTGCAAGACCTCATCGGCGCATCATCCTCCCCGGGCCGGGCGTG180 CGCGCCTCGATTGTTGTGTCCGCCGCGCTGCAAGCAAGTTGCAGGCCGCTGCCGAGCGTC240 GCGCGCTGGCCGCGGAACGATTGCCCGCCTGCACGATAACCCAGCACGACGCACTTTGCC300 GGGGCACGCCTGGCCAGCTTTTTCTTATGTCCCGAGGACATTTTTAATAATTTTCCTTCG360 CCGCGGCTTGCGCGACCATCCTTCCCCATCGACCCCATGGACAGCGGTTCGCCTCCCGGC420 GGTCCGGGCCATGCGTGCAGAACCACGACCGGCGCAGACCGGCGAGATAACAAGGAGAAG480 GTGGGGTGTTCGAACTCAGCGATTGGCAACGGCGCGCCGCGACACAGCGCTTCATCGACC540 AGGCCCTGATCGGCGGCCGCCAGCGTCCAGCCGCCAGCGGCGCTACCTTCGACGCCATCG600 ATCCGGCGAGCAATCGCCTGCTGGCGCGGGTCGCGGCCTGCGATGCGGCCGACGTCGACG660 CGGCAGTGGCCGCCGCCCGCCGCGCCTTCGACGAAGGCCCCTGGGCGCGTCTCGCCCCGG720 TCGAGCGCAAGCGCGTGCTCTGCGCCTGGCCGAGCTGATGCTGGCCCATCGCGAAGAGCT780 GGCGCTGCTCGACTCGCTGAACATGGGCAAGCCGGTGATGGACGCCTGGAACATCGATGT840 ACCCGGCGCCGCCCACGTCTTCGCCTGGTATGCGGAAAGCCTCGACAAGCTCTACGACCA900 GGTCGCGCCGGCCGCCCAGCAGACCCTGGCCACCATTACCCGCGTGCCGCTGGGGGTGAT960 CGGCGCGGTGGTGCCGTGGAACTTCCCGCTCGACATGGCCGCCTGGAAGCTCGCCCCGGC1020 CCTGGCCGCCGGCAACTCGGTGGTGCTCAAGCCGGCCGAGCAGTCGCCGTTCTCCGCCCT1080 GCGCCTGGCCGAGCTGGCCCTGGAGGCGGGGGTGCCGGAAGGCGTGCTGAACGTGGTGCC1140 GGGCCTCGGCGAGCAGGCCGGCAAGGCCCTCGGCTTGCACCCGGAGGTGGACGCACTGGT1200 GTTCACCGGCTCCACCGAGGTCGGCAAGTACTTCATGCAGTATTCCGCGCAATCCAACCT1260 CAAGCAGGTCTGGCTGGAGTGCGGCGGTAAGAGTCCGAACCTGGTGTTCGCCGATTGCCG1320 CGATCTTGACCTGGCGGCGGAAAAAGGCGCCTTCGGCATTTTCTTCAATCAGGGCGAGGT1380 CTGTTCGGCGAACTCGCGCTTGCTGGTGGAGCGTTCGATCCACGACGAGTTCGTCGAGCG1440 CCTGCTGGCCAAGGCCCGCGACTGGCAGCCGGGCGATCCGCTGGACCCGGGCCAGCCGCG1500 CCGGCGCCATCGTCGACCGCCGGCAGACCGCCGGGATTCTCGCCGCCATCGAGCGGGCGC1560 AAGGCGAGGGCGCGACCCTGCTCGCGGTGGCCGCCAGTTGACGATCAACGGTTCGGACAA1620 CTTCATCGAACCGACCCTGTTCGGCGACGTACGCCCGGACATGCAGCTGGCCCGCGAGGA1680 AATCTTCGGCCCGGTGCTGGCGATCAGCGCCTTCGACTCCGAGGACGAGGCCATACGCCT1740 GGCCAAGGACAGCCGCTACGGCCTCGCCGCCTCGCTGTGGAGCGACGACCTGCACCGTGC1800 GCACCGGGTGGCGCGGCGCTTGAATGCCGGAACGTGTCGGTGAATACCGTGGACGCGCTG1860 GACGTCGCGGTGCCTTTCGGCGGCGGCAAGCAGTCCGGCTTCGGTCGCGACCTGTCGCTG1920 CATTCCTTCGACAAGTACACCCAGTTGAAGACGACCTGGTTCCAGTTGCGCTGAAGACGC1980 GACGGACGCGACACGACTCGATGCCGATAACGACAACAAGAGGACGATCGAATGAACGAC2040 ACGCCGAACGTGCGTGAGCCGGCCCTGCGCCGCGTGCTCGGGCTGGGACCGCTGCTGGCG2100 GTGGCCATCGGCCTGGTGGTTTCCCAGGGCGTGATGGTACTGATGCTGCAAGGCGCCGGG2160 ACGGCCGGCCTGGGCTTCATCGTGCCGCTGGGAGTGGCCTACCTGCTGGCGCTGACTACG2220 CCTTTTCCTTTTCCGAGCTGGCCCTGATGATTCCCCGCGCCGGTAGCCTGAGCAGCTACA2280 CCGAGGTGGCCATCGGGCATTTCCCGGCGATCCTGGCGACCTTTTCCGGCTACGTGGTGG2340 TGGCGATGTTCGCCCTCTCGGCGGAACTGCTGCTGCTCGACCTGATCATCGGCAAGGTCT2400 ACCCCGGCGCGCTGCCGCCGATGCTGGTGCTACGGCGTGCTCGGCCTGTTCACCCTGCTC2460 AACCTGCTCGGCATCGACATCTTCGCGCGCCTGCAGAGCGCGCTGGCGCTGCTGATGATG2520 ATCGTCCTGCTGGTGCTCGGCCTGGGTGCGGTGAGCAGCGACCACGCTTCCGCGCAGACC2580 GCCCTGGCGAGCGGCTGGAACCCGCTGGGGGTAAGCGCCCTGGCGCTCACCGCGATGGCC2640 GTGTGGGGCTTCGTCGGCGCCGAGTTCGTCTGCCCGCTGGTGGAGGAGACGCGGCGTCCG2700 GAGCGCAACATCCCGCGTTCGATGATCCTCGGCCTGAGCATCATCTTCCTGACCATCGCC2760 CTCTACTGCTTCGGTGCGCTGCTGTGCATCCCGCAGGCGGAACTGGCCGGCGACCCGCTG2820 CCACACTTCCTCTTCGCCAACCGCGTGTTCGGCGAGTACGGCCAGCTGTTCCTGGTGATC2880 GCCGCGATCACCGCCACCTGCAGCACCCTCAACTCGTCGCTGGCGGCGATCCCGCGGATG2940 CTCTACGGGATGGCGCAGAACGGCCAGGCCTTCCCGCAATTCAAGCAGCTCAGCCGGCGG3000 GCGCGCACGCCCTGGGTGGCGGTGCTGTTCGTCGCCGCGATCACCGGCCTGCCGATCCTG3060 ATCCTCGGCCAGGACCCGGACTCGATCAACCTGCTGCTGCTCGCCGCCGCGCTGGCCTGG3120 CTGCTGGCCTACATCATCGCCCACGTCGACGTGCTGGCCCTGCGCCGTCGCTATCCGCAC3180 ATCGCCCGTCCGTTTCGCACGCCGTTCTACCCGCTGCCGCAACTGTTCGGCATCGCCGGG3240 ATGATCTACGCGGTGGTCCACGTCTCGCCGACCCCGGAAATGACCGGACGGATCTTCGCC3300 AGCGCCGGCGTGGTGCTCGGCGTGGTCTCGCTGGTGGCGGTGGTGTGGATCAAGGGCGTG3360 ATGCGCAAGCCCCTCTTCGTACCCGAACCGCTCGAGACGGCCGGTGAGACTGCCCAGGGC3420 AAGTCCGTCGCCCTCGATCCCCTGCAATCCCTTCGGCCTGACGCGCCAAGGGAACAAGGA3480 GAACACAGACGATGACCGCTCAGCTCAACCCGCAGCGCGACACCCGCGACTACCAGCAAC3540 TGGACGCCGCGCACCACATCCACGCCTTCCTCGACCAGAAGGCGCTGAACCGCGAAAGGC3600 CCGCGGGTGATGGTCCGCGGCGATGGCCTGCAGCTCTGGGACAACGACGGCAAGCGCTAC3660 CTGGACGGCATGTCCGGCCTCTGGTGTACCAACCTCGGCTACGGCCGCCAGGACCTCGCC3720 GCCGCCGCCAGCCGCCAGCTGGAACAACTGCCGTACTACAACATGTTCTTCCACACCACC3780 CACCCGGCGGTGGTGGAGCTTTCCGAGATGCTCTTCAGCCTGCTGCCGGACCACTACAGC3840 CACGCGATCTACACCAACTCCGGCTCCGAGGCCAACGAGGTGCTGATCCGTACCGTGCGG3900 CGCTACTGGCAGATCCTCGGCAAGCCGCAGAAGAAGATCATGATCGGCCGCTGGAACGGC3960 TACCACGGCTCGACCCTGGGCAGCACCGCGCTCGGCGGGATGAAGTTCATGCACGAGATG4020 GGCGCATGCTGCCGGACTTCGCCCACATCGACGAACCCTACTGGTACGCCAACGGCGGCG4080 AGCTGAGCCCGGCCGAAGTTCGGTCGCCGCGCGGCGCTGCAACTGGAGGAGAAGATCCTC4140 GAACTGGGCGCGGAGAACGTCGCCGCCTTCGTCGCCGAGCCCTTCCAGGGCGCCGGTGGC4200 ATGATCTTCCCGCCGCAAAGCTATTGGCCGGAGATCCAGCGCATCTGCCGGCAGTACGAC4260 GTGCTGCTGTGCGCCGACGAAGTGATCGGCGGCTTCGGCCGCACCGGCGAATGGTTCGCC4320 CACGAACACTTTCGCTTCCAGCCGGACACCTTGTCCATCGCCAAGGGCCTGACGTCCGGC4380 TACATCCCCATGGGCGGCCTGGTACTCGGCAAGCGCATCGCCGAGGTGCTGGTGGAGCAG4440 GGCGGGGTGTTCGCCCACGGCCTGACCTATTCCGGCCACCCGGTGGCGGCGGCGGTGGCC4500 ATCGCCAACCTCAAGGCTGCGCGACGAGGGCGTGGTCACGCGGGTCAGGGAGGAGACCGG4560 CCCCTACCTGCAACGCTGCCTGCGCGAGGTCTTCGGCGACCATCCGCTGGTCGGCGAGGT4620 CCAGGGCGCCGGCTTCGTCGCCGCGCTGCAGTTCGCCGAGGACAAGGTGACCCGCAAGCG4680 CTTCGCCAACGAGAACGATCTGGCCTGGCGCTGCCGCACCATCGGCGGCTTCGAGGAGGG4740 CGTGATCATCCGCTCCACCCTCGGCCGCATGATCATGGCCCCGGCGCTGGTGGCCGGGCG4800 TGCCGAGATCGACGAACTGATCGACAAGACCCGTATCGCGGTGGATCGCACCGCGCGCGA4860 GATCGGCGTGCTCTGACGCGCCCCGGCGGCCCGGCCTCGGCCGGGTCGCCTGCGACACGG4920 AGCGTCCCCCCATAACGACGATGCGGCGCCTGGCGACCGCGCGCGGAACCGTTTCGGCCT4980 CTGGCGGCAACTGCCTAAGCAACATCACAACAATGCCAATCGGCTGTGGGAGTGTTCCAT5040 GTTCAAGTCCTTGCACCAGTACGCACACGTGTTTTCCCGGTTGTCCCTGTTCGTCCTGGC5100 GTTCGCCGCGGCGGCCCAGGCGCAGAGCCAGAGCCTGACGGTGATCTCCTTCGGCGGCGC5160 GACCAAGGCCGCCCAGGAACAGGCCTATTTCAAACCCTTCGAGCGAAGCGGCGGCGGGCA5220 GGTGGTCGCCGGCGAATACAACGGCGAAATGGCCAAGGTGAAGGCCATGGTCGACGTCGG5280 CAAGGTCAGCTGGGACGTGGTCGAGGTGGAGAGCCCCGAACTGCTCCGCGGCTGCGACGA5340 GGGGCTGTTCGAACGCCTCGACCCGGCGCGTTTCGGCGACCCCGCGCAGTTCGTCCCCGG5400 CACTTTCAGCGAGTGCGGGGTGGCCACCTACGTCTGGTCGATGGTGATGGCCTACGACTC5460 GACGAAGCTGGCCAGGGCGCCGCAGTCCTGGGCGGATTTCTGGAACGTCCGCGAGTTCCC5520 CCGGCAAGCGTGGCCTGCGCAAGGGCGCCAAGTACACCCTGGAAGTGGCGTTGCTGGCCG5580 ACGGGGTGAAGGCGGAGGACCTCTACAAGGTACTCGCCACCCCGGAGGGGGTCAGCCGCG5640 CCTTTCGCCAAGCTCGACCAGCTCAAGCCGAACATCCAGTGGTGGGAGGCCGGCGCCCAG5700 CCGCCGCAATGGCTGGCGGCCGGCGACGTGGTGATGAGCGCGGCCTACAACGGGCGCATC5760 GCCGCTGCGCAGAAGGAGGGGGTGAAACTGGCCATCGTCTGGCCCGGCAGTCTCTACGAT5820 CCGGAGTACTGGGCGGTGGTGAAGGGCACCCCGAACAAGGCGCTGGCGGAGAAATTCATC5880 GCCTTCGCCAGCCAGCCGCAGACGCAGAAGGTGTTCTCCGAGCAGATCCCCTACGGGCCG5940 GTACACAAGGGCACCCTGGCGTTGCTGCCGAAGACGGTGCAGGAGGCGCTGCCGACCCGC6000 GCCGGCCAACCTCGAAGGCGCGCGGGCGGTGGATGCCGAGTTCTGGGTGGACCACGGCGA6060 GGAGCTGGAACAGCGTTTCAATGCCTGGGCGCGCGCTGAGCGCTGCGCGTCGGCAAAAAA6120 AATGACGGGCCCCAAGTCGTCCGGGCCCGTCGGGTCAAAGCGCTGACGGGGTGATCAGCG6180 CAGCTCTTCCAACAACCCCTGCAGATACCGACAGCCCTCGGTATCCAGCGCCTGCACCGG6240 AAGGCGCGGCGCCCCCACCTCCAGGCCGGAGAGGCCCAGGCCGGCCTTGATGGTGGTCGG6300 CAGGCCCCGGCGGAGGATGAAGTCGAGCAGCGGCAACTGCCGGTAGAACAGCGCGCGGGC6360 CTTCTCCAGGTCGCCGTCGAGCACCGCCTGGTAGAGCTGGCCGTTGAGCGTCGGGATCAG6420 GTTCGGCGCGGCGCTGCACCAGCCTTTCGCGCCGGCCACGAAGGCCTCCAGCGCCAGCGC6480 GTTGCAGCCGTTGTAGAAGGGCACCCGGCCTTCGCCGAGCAGGCGCAGCTTGTGCATGCG6540 CTGGATGTCGCCGGTGCTCTCCTTGACCATGGTCACGTTGTCCACTTCGCGGACGATGCG6600 CAGGATCAGTTCCACCGACATGTCGATGCCGCTGGTGCCCGGGTTGTTGTAGAGCATCAC6660 CGGCACGCCGATGGCTTCGCCAACCGCGCGGTAGTGCTGGAACACTTCCGCCTCGTTGAG6720 CTTCCAGTAGGAGATCGGCAGGACCATCACCGCCTCGGCGCCGAGGGATTCGGCGAACTG6780 CGCGCGGCGCACGGTCTTGGCGGTGGTCAGGTCGGAGACGCTGACGATGGTCGGCACGCG6840 ATGGGCGACGGTCTTCAGGGTGAAGTCGACCACCTCGTCCCATTCCGGGTCGCTCAGGTA6900 GGCGCCTTCGCCGGTGCTGCCGAGCGGGGCGATGGCGTGCACGCCGCCGTCGATCAGGCG6960 CTCGATGGAGCGGCCGAGGGCCGGCAGGTCGAGACCGCCGTCGGCGCCGAAGGGGGGTGA7020 TGGTGTAGCCGATGATGCCGTGGATGGATGCGGACATTGGATGTACCCGTGACATTGAGT7080 GGGAAATGCCAGGACGGACCTGGTGGGAAAGGTCGTTCAGCTCAGGCAGTCGCTGTTGCG7140 CGGCAGGCAGCGCCGGGCGTAGTAGTTGAATGCGGCGCCGTGGCGCTTCGGGGTGGAGAT7200 CCAGTCGTGGGCCTCGCGCGCCAGGGCCGGCGGGATCGGCTTGATCTCTCCGGCGGCCAT7260 CGCCAGCAACTGCATCTTCGCCGCGCGCTCGAGCAGCACCGCGATCACGCAGGCCTCCTC7320 GATGCTCGCACCGGTGGCCAGCAGGCCGTGGTGGGAGAGCAGGATGGCGCGCTTGTCGCC7380 GAGGGCGGCGGAGATGATCTCGCCTTCCTCGTTGCCTACCGGCACGCCCGGCCAGTCCTT7440 GAGGAAGGCGCAGTCGTCGTATAGCGGGCAAAGGTCCATGTGCGAGACCTGCAGCGGTAC7500 TTCCAGGGTCGACAGCGCGGCGATGTGCAGCGGGTGGGTGTGGATGATGCAGTTGACGTC7560 CGGGCGGGCGCGATAGACCCAGCTGTGGAAGCGATTGGCCGGATTCGCCATGCCGTGCCC7620 GTGGAGGACGTTGAGGTCTTCGTCGACCAGCAGCAGGTTGCCGGCGCTGATCTCGTCGAA7680 GCCCAGGCCCAGTTGCTGGGTGTAGTAGGTCCCCGCCTCCGGGCCGCGCGAGGTGATCTG7740 CCCGGCGAGCCCGGAGTCGTGGCCGGCCTCGAAGAGAATCCGGCAGGTCAGGGCCAGCTT7800 TTGCCGGTCAGTCCACGTATTATCGCCGAGGCTGCTTTTCATCTGCTTCAGCGCGTGCTG7860 GATCAGTTGATCCTTGGGTAATTCCAGTGTCGTAACCATGCGAGGTTCCTTTGACGGAGC7920 GAGTCGGGGGAAACGCCAGGCAGTTGCGCGCCACGCAACGACCCGGCTGTAAATGACACG7980 GATCAAGTTATATGACACAAAGTGTCATTTAGCAAGAGAGAAGTTTCATCGCCATCGGGA8040 GAAGGCTGTCCTCAATGTCCATGCGCTTGAAATTGCTGAGAAAAAAACTCGGGGTCACGC8100 TGGAGACCCTGGCCGACAAGACCGGCCTGACCAAGAGCTACCTGTCCAAGGTCGAGCGCG8160 GGCTGAACACGCCGTCCATTGCCGCCGCGCTGAAGCTGGCGAAGGCGTTGAACGTGCAGG8220 TGGAGGAGCTGTTCTCCGAGGAAAGCGACGGTGTCGACGGCTACAGCATCGTTCGTCGCG8280 ACCAGCGCAAGTCGCTGTCCAGCGGCGACGACGGCCCGGCCTACGCCTCCCTCGTCGCAG8340 CAGATCGGCGCCCGCGCGCTGTTGCCGTTCATCGTCCACCCCCCGCGCGATTTCAGTCAC8400 TCGACGTTCAAGGAGCACCTCGGCGAAGAGTTCATCTTCGTCCATGAGGGCCAGGTCGAG8460 GTCGACTTCATGAACCAGCGGATCATCCTCGAGCGCGGCGACGCCCTGCATTTCAACGCA8520 CAGAAGCCGCACCGCATCCGCTCCCTGGGGGAGACCCAGGCGGAATTGCTGGTGGTGATC8580 CACAGCGACGAATGAGGCGACGGCTTCGGTCGATCGGATGCTTGCTAACGTTCTGTTCGA8640 TTATCGAACTGTTAATCGATTATCGGATTGTGAGCCCTCGGACCCCGGCGTAAGGTTCTC8700 GTCACGTGCCGTCCAGGCAGCGCACAACAAGACGAGACCCGACCGATGGCTGAAATCCTC8760 TCCCTGCGCGAACGGTGCGACGCTTCGTCCACGATGGCGACAGCGTCGCCCTCGAAGGCT8820 TCACTCACCTGATCCCGACGNCCGCCGGCCACGAGCTGATCCGCCAGGGCAGGAAAGACC8880 TGACGCTGATCCGCATGACTCCCGACCTGGTCTACGACCTGCTGATCGGTGCAGGCTGCG8940 CGAAGAAGCTGGTGTTCTCCTGGGGCGGCAACCCCGGTGTCGGTTCGCTGCACCGCCTGC9000 GCGACGCGGTGGAGAAGGGCTCGGCCGCAACCGCTGGAGATCGAGGAACACAGCCACGCC9060 GACCTCGCCAACGCCTATTTTGCCGGCGCCTCCGGGCTGCCCTTCGCGGTNTGCGCGCCT9120 ACGCCGGCTCCGACCTGCCGAAGGTCAACCCGCTGATCCGCAGCGTCACCTGCCCGTTCA9180 CCGGCGAAGTGCTGGCGGCGGTGCCCTCGGTGCGTCCGGACGTCAGCGTGATCCACGCGC9240 AGAAGGCCGACCGCAAGGGCAACGTGCTGCTCTGGGGCATCCTCGGCGTGCAGAAGGAAG9300 CGGCCCTGGCGGCGAAGCGCTGCATCGTCACCGTCGAGGAGATCGTCGACGAACTGGACG9360 CCCCGATGAACGCCTGCGTCCTGCCGAGCTGGGGCGCTCAGCGCCGTGTGCCTGGTGCCC9420 GGCGGCGCGCATCCGTCCTATGCCCACGGCTACTACGAGCGCGACAACCGCTTCTACCAG9480 GACTGGGACCCGATCGCCCGCGACCGCGAAAGCTT9515 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2471 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Pseudomonas aeruginosa (B) STRAIN: Clinical Isolate P2- 7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: AAGCTTGTTCCAGGCCCTCGACCGCTGCGATCTTCTGCGGGTAGGCGGCGATGGTCTGTT60 CGGAGTTCGCCAACTGCAGGCGACGCTGCGCCAGCTGCGCCGCCTGCACGCCGGCAAGCA120 TCAGGTCCTGATCGAGCGAGGGGTTGAAGCCGCGCACGAACTCGCTGAACTGGTCCACGC180 CGAACAGGGTGGCGATGAGCTGGCGCTGATCGCTCGGGGTCCGCGCGGCGATTCGGGCGA240 AATCGTCGAGGCGGTTCTTCTCGATGAAGCAGAAGCGATACTCAGCTTCGTCGGGCTGGA300 CGGCCTGCGCCTCGCCCGCNGCCGTAGACGACAGGACTGGCGCGATGTGGCGGCGCAGGC360 GAGCGTTGTTGCAGTACGTCCGCTGGTCGACCGCTTGGCCTGCGCTTCGCTGATCGAACC420 GAGCATCGCCACTTCCAAGGCTTCGCAGAAGCTGCTCTTGCCGGTGCCGTTGGCACGTNA480 GACCAAGGTGATGTCATGGCTGAGGTCGAACGTCTCCTGCCGCATGAATCCTCGAAACGG540 CCCGACTTCGAGCTGGTGCAGTCGCCCGAGCGCCGGCCCGTTTTCGGGGCCGCGCGCGTC600 CCCGTCGTAGGCGACAGGCATCTGCGCCAAGATGCGCGATGGCCAGCGGCGCCAAGCCGC660 GTGGGAGCGCCCCCCGGCGTGCAGCACCGACCTCGGCCAGTGGCTGCAGGTGATCGAGCA720 CCAGGGTGCGCCAGCCGGCGCACCGTTTCGTCGTGCACGTGCCGCTGCGTCAAGTGCGCC780 AGGAACCGGTGGTACTCCGAACGTATGCTTGCCACAGCGACCCCTCACTTGGTCAACCAC840 TGACCGTAAGCCTCCACATCGATCATGGGGACCGTTCCACTGAACTGAAGCTGCGCGATC900 AGCTTGAAAAGAAACGCGGTCGCCGGCTTGTTTTCGTTGGTGTAGCTGTACGCGCCGCTG960 GCTTGGTCATAGAAAAAGTGCCCGTGGGCGGCAACGCATCCGATGTCCAGACGCCCCTCG1020 GTGAGGTTTGCGTTCAGCGCCTTGTCCATGGATGGGCCCAATGCAGGACTCCATTCGCTC1080 TCGAAGGTGAGCAAGCCACCCAGAATCGGAATCAACGCTTCGCTGGGTAGGTCCCGCCAG1140 CGTGCGGGATCGGCAGGCTCGTGCGGTGCAGCCTGCGCACACTGGCGACCTTCTCCTGGC1200 ATAGCCACAAGCCCCGCGTCAGCCGTCTGCTTGGCCTCGAACACGGCGTACACGCTTTCG1260 GCTGGAATGATCGTCTCGTTCTCGTAGGTGAAGATAAAAGGCGAATATTGCCGATCAAAC1320 ACCACCACATCGATCTGCTGGCTGAAGTTCCCCAGGCTGTCCACCACATGCGCCTTCGCC1380 GCCTGGTACCGTTTGGGCAGATAGGTATCCAGCATGTCGATCCAGACGTTCTCGCTCGCA1440 TCCCCCTTCGTACCCGGGTGACCGAAGGTCTTGCGTACTACGGACAAGCGCTGCTGGATG1500 TCTTCATGCAGGGACGACAGGAGCTGGGAAAGCGACCACTGGGACATGCTGTACCTCGAT1560 GGGACGTGTATGGAAGCCGATGGAATCAGGACAGTGGGAACTTGGGGCCAAACAGTGCGC1620 GCCAGGGCGAAGCGCTTCGATATTGCGACCACGACGCGTGTGGTCGATGGCGATGCTTGC1680 GTCCTGGCTCGCCTGGAACAGCAGCTGCTNGCGNGCGCTGCTTGCGCGCGGCATCCATAT1740 CGTTGCTGATCGCCGGGCCAAGTCCGGCGGGATCCGGCCACTCGTCATGAACACGATCGG1800 CAAGCGTGGCAAAGAACGACTGGATCTCGCGATCGAACGATCCTCCCCAGCCGCCGTAAA1860 GACACTCAAGGGCCATTACCTCGATCAGGAACGAGGGCTTCACCGGCTTCTGATCGCCGT1920 GCTTGGGATTGTTGTTCCAGTACTTCACCATGCGCACGAGACCTTTCCACTCATTGCCAT1980 AGGCTTGGTGCGCTGCGGTCGCCTTGTCCTTATGGATCTCCGGGTCCGTCTTGATCCACT2040 TTCCGGACGCCGTATCGGGGATCTCATACTGGTCGCCGGTGTCGAATGCGGGCACCGCAT2100 CCACGCTGACCACCCGGTAGTCCGTGTTGTCCTCCGCGTCGATGTGAACACCGAAATCCA2160 CGTTGATCGAGNGCGCCTGTTTGCGCACGGCCGCCGAACCGTATTTCTCCACCAATGCAG2220 AGTGGAAATCATCCAGCACTACCGATGCGGCCTTGCCGTGGTAATGCTTCTCCGAGTCCT2280 TCAGCACGAAGAAGATGTCGATATCCTTGAGCGGCTTCGTCTTCGTGTATCGAGCATAGG2340 ACCCGGTCAGGAACTGCGCGCAATGCCGAACTTGGTCTGCAGGTAGTCCCGCACTTCGTT2400 CTGGCGTTGCGAGGCATTCTTCTGCTCGCGTTCGTTGAGTTCCAGACGCGACTTGAACTT2460 GCGAAAAGCTT2471 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5247 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Pseudomonas aeruginosa (B) STRAIN: Clinical Isolate P2- 17 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: AAGCTTCGAGGGGGCTGGGCGAGGATCGACCGGCCCCGCTCGTGTCGGAAGGGAAGGCCA60 GGGCTGGCCTGCCCGTTCGGCGCTTCGGCAGGCTGGCGCAGAACGATGCAAGGTCGTTCG120 GGTCAGCATCAGGGATGAAATGACTGACAGGAGTCGGGATGCTGCGTTACGTCGTGGGTT180 TTCTCGCGTTCACCGTGCTGGCGGCCTATCTGTTGCTGGGGGTTTCCCAGCACGCCTTCC240 TGCCGTGACCGGTCGGCATGGCGGCTTCAGCTGCGTTGCGGAAGAGGCTGTGGCGGCCGT300 GCGGGATGCCGGTTTTCGGCTTGCCGTGCCTTGCGTTGCAGGCGTCGCGCCGACGCGGCA360 CGCCAGGGAAGGCCCACAGGGTGACGCCGGCGAGGCCCAGCCAGGCGACGATCAGCAATG420 TGACGAAGGATTCGGGAGTCATGGTTCGTCCTCCTCTTACCCAAGGATAGACCCTGCGGG480 AAGGGGAATTACTGCAATCGGTCTTCGACCATGGTCTGAAACGCGGTCACTCGGGGCCGG540 CGCCGACCAGGGCCAGGCAGCCGGTGAGGCTGGTCAGCAGGGGCAGGGCGAGCAGGAAAG600 CCAGCCAGATGGCCTCCATGCGCAACAGCGTGGCGCCGAGGAACAGCGCGACCAGGAGGA660 TGGTCATGAGCAGGGCGGTCCAGCCGAAGTACATGGCGAAGTTGTCGATGCCCAGGCCGA720 TGCCCCAGCCCAGCAGCAGGGCCCATACCCCGGCCAGAGCCAGGCCGAGGGCCAGCATGC780 TCGCCAGGGTCCGGGCGGACGGGGCATGCAGCGGGTGGTTGCGGAATAGCTCGTAGAAGA840 TCGGCGTATTCATCGGCGTCACCTCCGCAGGGGAACTTCCAGCCTAGTCCAGCGGGCGAG900 ACGGCCCTAGACCTATTTGTCATTACGAGGCGTGACCTCAGGCCGTTAACATCCATCTTT960 TTCCAGGCGATGCCGTGCATCGGGCTGCGGGCCCGCTCACCGTTCGTCGCGCTGAGTCGA1020 AAAAGAAACCGAAAGGGTTGCGTGCATGAGTTGGCGAACTCGCCTCGTTCGAGGTGGATG1080 GGTATCAACTGGTCTATCAGGACCTGGGTGAAGGCACGCCGGTGCTACTGGTCCACGGTT1140 CGCTGTGCGACTACCGCTACTGGCAATGGCAGTTGCGCAGCTCGGCAAGCACCACCGGCT1200 GATCGTGCCGAGCCTGCGTCACTACTACCCCGAGCGCTGGGACGGGCAGGGTGCGGACTT1260 CACCAGCGCCCGCCACGTCGCCGACCTGCTGGCGCTGGTCGAGCGGCTCGGCGAGCCGGT1320 ACACCTGCTCGGCCATTCCCGTGGCGGCAACCTGGCGTTGCGCCTGGCGCTGGCCGCTCC1380 GGACGCCCTGCGTTCGCTGAGCCTGGCCGATTCCCGGCGGCGACTATGCCGCCGAGGTCT1440 ACGCCCACGCCGGCCTGCCTGCGCCCGAGGAACCATTGGAACGCAACCAGTTCCGGCGCC1500 AGGCGCTCGAATTGATCCGTGGCGGCGAGGCGGAACGGGGACTGGAACTGTTCGTCGATA1560 CGGTGAGCGGCGCCGGGGTATGGAAACGCTCGTCGGCGACGTTCCGCCGAATGACGCTGG1620 ACAACGCCATGACCCTGGTCGGGCAGGTGGCCGACCAGCCGCCGGCGCTGGCGCTGTCGG1680 AACTGCGCTCGATCGACCTGCCGAGCCTGATCCTCAATGGCGAACGCAGCCCGCTGCCAT1740 TCCCGGCCACCGCCGAGGCGCTGGCGGCGGCCCTGCCGCGCGCCGAGCTGCAACGCATCC1800 AGGGCGCGTCCCATGGCCTCAATGCCACCCGTCCGGCGGCTTTCAACCGGTCGGTGCTGG1860 AGTTCCTGGCGCGCGTCGATGGCGTTGCGCCGGACGTGGAAACGTCCTGAAGCGAGGCCG1920 GGCGAACTGACCGCTCGTCAGCTCGCCGCGGATGCTTTACCATGCGTTCGCGCCGGATCA1980 GCTCCGGCGTTTTTCGTCAGTATCCATTCCCAGTGATCTCCGTCCGCGCGCTTCGGCGCA2040 GGGGTGCCGCAAGGCGCCTGCCACTGTGAGGCAGGCCGGCCCGGCGGGCGACGCTTACTG2100 GCACATCCCAACCCACGTGGCCTTTGGTAGGGTCACCACTAGAGAGAGCGCCATGCCCAT2160 CATTACTCTTCCCGACGGCAGTCAACGTTCCTTCGATCACCCGGTCTCCGTGGCCGAGGT2220 GGCCCAATCCATCGGCGCAGGCCTGGCCAAGGCGACCCTCGCCGGCAAGGTCGACGGCCG2280 CCTGGTCGACGCCTGCGACACCATCGATCGCGACGCGACCCTGCAGATCATCACGCCCAA2340 GGACGAGGAAGGACTGGAGATCATCCGCCACTCCTGCGCCCACCTGGTCGGCCATGCGGT2400 CAAGCAGCTCTATCCGACCGCGAAGATGGTCATCGGCCCGGTGATCGAGGAAGGCTTCTA2460 CTACGACATCTTCTTCGAGCGCCCCTTCACCCCCGAGGACATGGCGGCGATCCAGCAGGC2520 ATGCGCGAGCTGATCGACAAGGACTACGACGTGATCAAGAAGATGACCCCGCGCGCCGAG2580 GTCATCGAGCTGTTCAAGTCCCGTGGCGAAGACTAACAAGCTGCGCCTGATCGACGACAT2640 GCCGGACGAGAAGGCCATGGGCCTGTACTTCCATGAGGAGTACGTGGACATGTGCCGCGG2700 CCCGCACGTGCCGAACACTCGCTTCCTCAAGGCGTTCCAGCTGACCAAGATTTCCGGCGC2760 CTACTGGCGCGGCGACTCGAAGAACGAGCAGTTGCAACGCATCTACGGCACCGCCTGGGC2820 CGACAAGAAGCAACTGGCGGCCTACATCCAGCGCATCGAAGAGGCCGAGAAGCGCGACCA2880 TCGCCGCATCGGCAAGCAGCTCGACCTGTTCCACCTGCAGGAAGAAGCGCCGGGCATGGT2940 GTTCTGGCACCCGAATGCTGGAGCGTCTACCAGGTGCTCGAGCAGTACATGCGCAAGGTC3000 CAGCGCGACCATGGCTATGTCGAAGTGCGTACCCCGCAGGTGGTCGACCGCATCCTCTGG3060 GAGCGTTCGGGCCACTGGTCGAACTACGCCGAGAACATGTTCACCACCTCCTCGGAAAGC3120 CGCGACTACGCGGTCAAGCCGATGAACTGCCCGTGCCACGTGCAGATCTTCAACCAGGGC3180 CTGAAGTCCTACCGCGACCTGCCNTGCGCCTCGCCGAGTTCGGCGCCTGCCACCGCAACG3240 AGCCGTCCGGCGCGCTGCACGGATCATGCGGTACGCGGCTTTACCCAGGACGACGCGCAT3300 ATCTTCTGCACCGAAGAGCAGGTGAAGAAGGAAGCGGCCGATTTCATCAAGCTGACTTGC3360 AGGTCTACCGCGACTTCGTTTCACCGACATCGCCATGAAGCTGTCGACCCGTCCGGCCAA3420 GCGCGTCGGTTCCGACGAGCTGTGGGATCCCGAAGGCGCGCTGGCCGATGCGCTGAACGA3480 ATCCGGCCTGGCCTGGGAATACCAGCCGGGCGAGGGCGCGTTCTACGGGCCGAAGATCGA3540 GTTCACCCTGAAGGACTGCCTCGGCCGTAACTGGCAGTGCGGCACCCTGCAGTACGACCC3600 GAACCTGCCGGAGCGCCTGGACGCCAGCTACATCGCCGAGGACAACAACCGCAAGCGCCC3660 GGTGATGCTGCACCGTGCGATCCTCGGGTCCTTCGAGCGCTTCATCGGCATGCTCATCGA3720 GCACTACGCCGGAGCCTTCCCGGCCTGCTGGCGCCGACCCAGGCAGTGGTGATGAACATC3780 ACCGACAAGCAGGCCGATTTCGCCGCCGAGGTGGTGCGGATCCTCGGGGAAAGCGGATTC3840 CGTGCCAAGTCCGACTTGAGAAACGAGAAGATCGGCTTTAAAATCCGCGAGCATACTTTG3900 CTCAAGGTTCCCTATCTCTTGGTTATTGGAGATCGGGAAGTTGAATCGAAGGCCGTCGCG3960 GTGCGTACGCGCGAAGGGGAAGACCTGGGCTCCATGCCCGTCACCCAGTTCGCTGAGCTG4020 TTGGCACAGGCGGTTTCCCGGCGTGGTCGCCAAGACTCGGAGTAATCATTATTAAGCGTG4080 AAATGAGACAGGATAAGCGAGCTCAACCGAAACCCCCGATCAACGAGAACATCTCGGCTC4140 GTGAGGTACGGTTGATTGGAGCTGATGGCCAGCAGGTTGGTGTTGTTTCGATCGATGAGG4200 CGATCCGCCTAGCCGAAGAGGCGAAGCTGGACCTGGTTGAGATTTCGGCCGACGCGGTGC4260 CTCCTGTCTGCCGCATCATGGACTACGGCAAGCACCTGTTCGAGAAGAAGAAGCAGGCTG4320 CGGTCGCCAAGAAGAACCAGAAGCAGGCGCAGGTCAAAGAAATCAAGTTTCGTCCAGGGA4380 CGGAAGAAGGGGATTACCAGGTAAAACTACGCAACCTGGTACGTTTCCTTAGTGAAGGGG4440 ACAAGGCCAAGGTATCCCTGCGATTCCGCGGCCGTGAGATGGCTCACCAGGAGCTGGGGA4500 TGGAGCTGTTGAAGCGGGTCGAAGCCGACCTCGTGGAGTACGGCACCGTCGAGCAGCATC4560 CTAAGCTGGAAGGACGCCAGCTGATGATGGTCATCGCTCCCAAGAAGAAAAAGTAACCAC4620 CAGGGCACTGGCAGGCCTTGCGGTTATGCGTAATCACTCAATGCGGAGTATCCGAACATG4680 CCAAAGATGAAGACCAAAAAGTGGGCGCGGCCAAGCGCTTCAAGAAGACTGCTGGTGGCC4740 TCAAGCACAAGCACGCCTTCAAGAGCCACATCCTGACCAAGATGACCACCAAGCGTAAGC4800 GTCAACTGCGCGGCACCTCGATGCTGAACAAGTCTGACGTTGCGCGCGTAGAACGCTCCC4860 TGCGTCTGCGCTGATTATTAAGGTAGAGGATTAATTCATGGCTCGTGTTAAGCGTGGCGT4920 TATCGCCCGTCGTCGTCACAAGAAAATTCTGAAGCTCGCCAAGGGCTACTACGGTGCACG4980 CTCGCGCGTGTTCCGCGTTGCCAAGCAGGCGGTGATCAAGGCTGGCCAATACGCCTACCG5040 TGACCGTCGTCAGCGCAAGCGTCAGTTCCGCGCACTGTGGATCGCCCGTATCAACGCTGG5100 TGCTCGTCAGAACGGTCTGTCCTACAGCCGCCTGATCGCCGGCCTGAAAAAGGCGGCCAT5160 CGAGATCGACCGTAAGGTCCTGGCCGATCTGGCAGTGAACGAAAAAGCGGCGTTTACCGC5220 GATTGTCGAGAAAGCGAAGGCAAGCTT5247 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2812 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Pseudomonas aeruginosa (B) STRAIN: Clinical Isolate P4- 5 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: AAGCTTTGGTGATCTTAACGTGACAAGCTCCTTAGAAAAATTTTATGAGTTTATTAGCGG60 GGTCTTTCTTGATCCGACTGTACCAAGACTTTCAACTCGTAAAATACGCAAGCACAAAAG120 CACTGAAATGCACTCTGCACGTTTGTCGCCGTCCACGGTAGCGGCATCCCTCAATCACAC180 CGAAGCGGTGAATCTTTCTACCTATGCAGAGGCAACACCTGAACAGCAGCAATCCGAGTT240 CAGCCTGTTTTGGGATGCAATACGCCACGCTGCTCATGTTGTGCGTGAGCGAAGCCGCAA300 GGCTGTAGCAAGTAGTGTCGCAATAGCGGCGGGTCACTGCGAGGATTTCAATAAGCCGAC360 GTCTGCCACTGATGTGGGATTGATTATAGAGCCGAACTGCCGCACCCAATATGGTTGTTT420 GTACTGCGAAAACTATTTATGTCACGGCGATGAGGAGGATCTGCATAAAATTCTGAGTTT480 GCAATACGTGGTCAATGCCGTGCGTAAATCGGCCCCCGATGCAGCGCATACTGAGGCACT540 TTTCAAAGAGTTATCTATCCGGATCGAGTTTATAGTCGATGCTCTTAGTGAGCGCTCTAG600 CTCGGTGAAACAGACAGTCGAAAAGGTTAAAGCTAAGGTGTTTGAATACGGCGAGTTAAC660 TAAGTTTTGGGAAGTCCGGTTGGGTCGCTATGAAAAAATGGGGATCGTATTTTGAGTGCT720 GCTGTTCAGTCGATAGGTAGTCTTTTTTCTAGCGGCCAGTTTCCAGTCACCAGCCAGCCA780 GATAGTGCGGCTCAGCTGTATGGGAAGCCCGCGTCGGATTTTGTTATCTGTCGCACTGAG840 TATGGCAATGCAACGGCAGTGTACGGCGAGTCTGTATGGGACTTTAACCCGTACAGGCTG900 AGTGCAAAAAAAATTGGCCGAATACGCTTCGATATGGTGTTCGGTGATTATGGTCATGAT960 CAGCAAGCGCTGATCGAAGAAGCCAAATATCTTCTGTATTGTCTTATTTATTTCGCTGGC1020 GGTGGGCGGATTGGTAAGCTGAGTGCATCTACGATTATTTCATATTGGGTTGTGCTGCGC1080 ATCGCTATGAAGTTCTGCTATGCGCAGAAAAAGAAGTCAATGGTTGGTGTGCTGTCCTTG1140 CAGCAGCTTTTTACCGTGCCTGTTTATCTAGCGGCTTTTGTTAGTGAAAGTAATTTTGAC1200 AAGACGGTTCTTAGTGGGATATTGCACGGATTGATTAGTGTGGGCGAGGAACGCCTAGGG1260 TATGTTGTGCTGAATCCAAGAGTTTTTGATTTGAGAAGACCTGATTCTAAACAGCATTCC1320 GGTAATTCCGACACGCCTTTATTTGAATTTAATAATATTGTGGCGACCTGCTCGATCATC1380 TTACTTGGGTGTTGGGAATATTGATTCATTTATATCGTGCTTTGCTGATGAGTATTTCGG1440 TCTTACTCCGCACCGTCAAAAATCTTTGGGGGTTGGTGGTAAGTCGCGCTATCGCCCCGG1500 TATTCAGCAAGCAATAGAGGAATATGGTCTGGCTGCGGTTTTTGTCGGTGAGTTTGCCTG1560 TTCCGAAAAGAGAAAGCTGCAGCGAGTCCTTCTCAAGATGCAGTATGTGGTGAGAATGGT1620 GATACACCTATATACCGGCATGCGTGATCAAGAGGTGATGCGTATGTCTTATAACTGCTT1680 ATCTGATCAAGTCGTGAGATGTTCAGTGGTTGATGATCAAGGTTTTATGCGCGATCAACC1740 GCAATCAGTACACATATTATCGACTACCACGAAGTTTAGCGGTTACAAGAAAGAAAGCGC1800 ATGGTTCGCGGCAGGCGAAGTCGTCAAGGCGGTCGAGGTTGGCCAGGCGATTTGTCGTGG1860 TTTAGCCCGGCTCTATAGGATTGAACTGGATGATCGTTGTCCGCTATTCATCAATCCGTC1920 CGTCCTGTGTAAAACGAAGAATTGTGCAGAAGTTGGTGTAACAGACTTTACATTGAGAGC1980 AACGATGGCAGTGCTTTGAAATCCTTATCGATTCAATCAGAGGATTTACAAGAGTTGGCT2040 CAGAGCGACCCTTCTCGTGACTTTTACAATGAGCCAGATTTTGCAGTAGGCCAGCCCTGG2100 CCGCTGACTAGCCATCAATTCCGACGTTCGTTGGCCTTCTATGGAAGCAGTAGCGGCTTT2160 CTCTCGTTACCGACTCTGCGAGCGCAGTTCAAGCATATGACCCATTCAGATGGCGCGCTA2220 TTATGCGAATGGCTTTGATAACTTGCGCACCATTTTTGGCTACTATGACGAGAAGAAAAT2280 AGACTTCGTGCTACCATATAACCACTTTGCTTTCGAGTTCCAGATGGCCATGCCGATGTC2340 GGTGGCCAATCAGTTGATTGCAGATCTGCTGTTCAAAGAAGAACCGCTGTTTGGTGGCAC2400 CGGTTCATACATGCAGAGGCAGAAAGAACGTGTTGAAGCTGGCGAGATAAAGATTGAAGA2460 TATTCGTGCCGATACAGAGCTTCGGGTGAAGAACGGTGCAATTAGCTATCGGCCAACGCT2520 ACTCGGTGGTTGCACCAAGGTGGGCCGCTGCGATTCCTTCATGCTCGGTGACTATACTGA2580 ATGTTTGTCCTGCGAGGGTGCGATTATCAAGCCCTCCAGGTTAAGTGCGGCCATTGAGGA2640 TGCGAAAAACGAGTTGTCAAACTACGCAGAAGACTCAGGCGAATATCAAATTGTGAAGGG2700 CGATATTGAGCGCCTAATGGTTTTCAAGACTCGCCTGATCGACACTGTGGAGCTTTAGTC2760 ATGAAGTCTGGTGAAGGAATAAGCAAGGGGGTTGGTGCCTGTCAGGAAGCTT2812 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3615 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Escherichia coli (B) STRAIN: Clinical Isolate EC- 24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: AAGCTTTTCTTGCGTGTTCTTGTGAGGCTTCCTTCGCCATTATCATCACGATCCACATAA60 ATAAAGCCGTAGCGCTTAGACATTTGTGAATGAGATGCACTGACTAAATCAATTGGCCCC120 CAACTGGTGTACCCCATAATATCCACACCATCGGCAATCGCTTCATTTACCTGTACCAGG180 TGATCGTTTAAATAGGCAATTCGATAATCGTCCTGTATCGAACCATCCGCTTCAACGCTG240 TCTTTTGCGCCTAATCCGTTCTCGACAATAAATAACGGTTTTTGATAACGATCCCAAAGC300 GTATTTAACAGAACCCGTAATCCAACCGGATCAATTTGCCACCCCCACTCTGAACTTTTC360 AGATGCGGATTGGGGATCATATTCAGTATGTTGCCCTGCGCATTTTTATTAATGCTTTCG420 TCGTGGGAACACAACCAGTCATGTATAACTAAAGAGATGAATCGACGGTATGTTTTAAAT480 CTCTGCGTCACTTTCAGTCATCTCAATGGTGATATTGTGGTCGCGGAAGAAACGCTGCAT540 ATAGCCGGGATACTGGCCACGCGCCTGAACATCACCAAAGAACATCCAGCGCCGGTTCTC600 TTCCATGGCCTGCAACATATCCTGTGGCTGGCAGGTGAGGGGGTAAACCAGCCCACCGAG660 AAGCATATTGCCGATTTTCGCTTCGGGGAGCAGGCTATGACAGGCTTTAACTGCCCGCGC720 ACTGGCAACCAGTTGATGGTGGATAGCCTGATAAACTTCCGCCTCGCCACTCTCTTCTGC780 CAGCCCCACGCCCGTGAATGGCGCGTGTAACGACATGTTGATTTCATTAAACGTCAGCCA840 TAACGCCACTTTATGTTGGTAGCGAGTAAAGACCGTGCGGGCGTAATGTTCGAAGTGATC900 GATGACCGCTCGATTAGCCAACCGCCGTAGTTTTTCACCAGCCCATATGGCATTTCGTAA960 TGGGATAACGTTACCAGCGGCTTGATCCCCGCCTGCGCCATTTCATCAAACAGCCGATCG1020 TAAAACGCTAACCCCGCTTCATTCGGTTCGACTTCGTCGCCCTGAGGGAAAATTCGCGCC1080 CAGGCAATGGAAATACGCAGACAGGTGAAGCCCATCTCGGCAAATAACGCGATATCTTCC1140 GGGTAACGGTGATAAAAATCGATGGCGACATCTTTGATATTCTCTTTCCCCAGGATGCGC1200 GGTTCCATTTTTCCCATTACGCATGAGGCTGTAAATCTGAGGTCGAGATCCCTTTGCCAT1260 CTTCCTGCCAGGCACCTTCCACCTGATTGGCAGCTGTTGCGGCACCCCAAAGAAATGTTT1320 CTGGAAATGCTTTCATAATTAACTCCTTTTATCGTTAGCGAATGATGGATAACAGCGGTT1380 CACCTGCGCTTATCTGCGCCGTGCCGTGGGGTAATACGTCCGTAAAATCATCGCTATTAC1440 TGATTAATACCGGCGTCGTCAGATCAAATCCGGCCTCGCGAATAGCAGGGATATCAAAAG1500 AAATCAGCCGATCGCCTGTATTGACCTTGTCACCCACGTTGACGTGAGCGGAAAAGAATT1560 TGCCGTCCAGTTTTACGGTGTCGATACCGACATGAATCAGGATCTCCACACCATCATCTG1620 ACTCAATGCCAATGGCGTGTAATGTGGCGAACAACGAAGCAATTCGACCCGCAACCGGAG1680 AACGCACTTCACCAACCGAGGGCAGAATGGCAATACCTTTACCCAACAGGCCACTGGCAA1740 ACGTGGTATCAGCGACGTGAATGAGCGACACAATCTCTCCCGTCATCGGTGAACAGATAC1800 CGCCCTGCTCAGGTGGTGTAATAACCTCTGGTGTTTTCTCTTCGGGGCACCCTGCGCTGG1860 CTGACGTTTAGCGGTGATGAAATGAAGCATCACCGTACCGACAAATGCGCAACCGATGGC1920 AATGACACCGCCAATAACGCTGGCCCAGACGGTGAAATCAATTCCCGTTGACGGGATGGT1980 TTGCATGAAGGTGAAAATACTTGGCAAACCAAAGGAGTAGACTTTCGTTTGCGCGTAGCC2040 AATAATGGTGGCCCCCAAAGCCCCACTGATACAGGCGATAACAAAGGGGTACTTACGCGG2100 CAGGTTGACGCCATATACCGCTGGTTCGGTGATACCAAACAGACTCGTCAACGCCGCTGA2160 TCCCGCCACCACTTTTTTCTGCGCATCGCGTTCGCAGAGGAAGACGCCGAGCGCCGCCCC2220 GACCTGCGCCATAATGGCGGGCATTAACAGCGGGATCATGGTGTCGTAGCCCAGCACGGT2280 GAAGTTATTGATACACACCGGCACCAGGCCCCAGTGCAGTCCGAACATGACGAAGATTTG2340 CCAGAAGCCGCCCATTACCGCGCCCGCAAATGCAGGAACCGCCTGATAAAGCCAGAGATA2400 ACCGGCGGCAATCAGTTCGCTTATCCAGGTTGATAGCGGCCCCACCAGCAGAAAGGTGAC2460 GGGTGTGATAACCATCAGACATAGCAATGGTGTGAAGAAATTTTTGATTGCCGACGGTAA2520 CCACGCATTAAGTCGGCGTTCCAGAATGCTGCACAACCAGGCAGAAAAAATAATGGGAAT2580 AACCGATGACGAGTAATTCAACAATGTGACCGGAATACCCAGGAAATCCAGCCCCAGCGC2640 ATCCGCTTTTGCGCGTTCTCGAAAAGCAGTACAGAATTAATGGATGCACTAACGCTCCAC2700 CAATCACCATGGCAGTAAATGGATTATCGCCGAAGCGTTTCCCCGCGGTGTATCCCAGGA2760 TTATCGGGAAGAACCAAAACAAGGCATCACTGGCGCTGAATAAAATTAAATAAGTACCAC2820 TTTGTTCGGGCGTCCACTGAAAAGTGAGCGCCAGAGCCAGCATACCTTTCAAGATCCCCG2880 GTTGCCCGCCATCAAACCGATACAGAGGCGTAAAAATACCTGAAATAACATAAACAAAGC2940 GGTTTAGACAGATTACCTTTATCATACATTTTCCGGTGCCTGTTGCGCTTTTTCGTCAAG3000 GCCTGCCACACTGTTAACCGCCAGGAAGACATCGGCCACATGGTTACCTATGACCACCTG3060 AAACTGGCCACCGCTTTCCACCACCATAATAATACCGGGGGTCTTTTTCAGTACCTCTGC3120 TTGCGCTTTGCTTTCATCCTTTAATTTAAAAACGTAAATCGCGTTGCGCAATGCATCAGA3180 CTCACAATGTTATCTGCGCCCCCGACTCCTGCGACTATTTTTCTGGCTAACTCCGTCATA3240 ACTTGCCCTCTACGCTTTGCGGCAAAACTCCAAAAAAAAACCTGAAAAAAACGGCCTGAC3300 GTGAATCAAGCAATTTTTTTCAGGTTTTGCCCGCTTAGTGCGGTAACAATCCTTTACTCA3360 GTAATAATATTTCAGTGTTCTTTGCGCACGCGCTCTATATTTATGGCTAAAAACATAATC3420 TCTGCGGGTGAAATTTTACGTTGATACTGCAAACCAATAAAAATGGCGATCCGTTCCGCA3480 CATTGCCATGCTTGCGGGTAATTTTGTTTTACTGCTTGTTGTAATGATTCATCACTATCG3540 TTAATTGAAGCATGTTCAAGAATACGCCAGGATAAAAACTTCAGATGTGTAACCAGTCGC3600 TGATAACTCAAGCTT3615 (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4954 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Escherichia coli (B) STRAIN: Clinical Isolate EC- 34 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: AAGCTTAACCGCTCTCATCTGTTGACCGCACGGCATAGCTATATTCTGCCGGTCCTGGGA60 CGTAGCGAGATTGACATGCAAAAAAACGGTGCGCAGGCGGTAACCGTTGAGGATTCAATG120 TCGATGATTCATGCCTCGCGTGGCGTGTTAAAACCCGCCGGTGTAATGCTGAAATCAGAG180 TGTGCAGTGGTCGCGGGAATCGCGCAGGCAGCACTACCCCAGAGCGTGGTAGCCTGGGAG240 TATCTGGTGGAAGATTATGATCGCATTCGCAATGACATTGAAGCTGTGCTGCCAGAGTTC300 GCCGACTATAACCAGCGCATCCGTCATCCCGGTGGTTTTCACCTGATAAATGCAGCTGCT360 GAAAGGCGCTGGATGACGCCGTCAGGTAAGGCTAATTTCATTACCAGCAAAGGGCTGTTA420 GAAGATCCCTCTTCAGCGTTTAACAGTAAGCTGGTCATGGCGACAGTACGCAGCCACGAT480 CAGTACAACACGACGATTTATGGTATGGATGATCGCTATCGAGGGGTATTCGGTCAACGA540 GATGTGGTCTTTATGAGTGCTAAACAAGCTAAAATTTGCCGTGTAAAAAACGGCGAAAGA600 GTTAATCTTATTGCGCTTACGCCAGACGGTAAGCGCAGTCACGCCGCATGGATAGATTAA660 AAGTGGTCATTTACCCTATGGCTGACCGCTCACTGGTGACCTATTTTCCAGAATCGAATC720 ACATGCTAACACTTGATAACCACGATCCATTAAGTGGCATTCCTGGCTATAAAAGTATTC780 CGCTTGAATTAGAACCATCAAATTAATGTCTCTTCTCATTTCTTCTGCTGTCATCCGCAC840 AGCAGAAGAATTCCTCATTGACTATTATTTCGCAATTTGCTCACATGGATTAAATTAAAC900 TACATACTATAAGATATAAACTTCTGCCTACAGCTGTAAGAAACTCCGCTCAGTACTGAA960 GCACCAGTCCTATTTCCTCTTTTCTCCAGCCTGTTATATTAAGCATACTGATTAACGATT1020 TTTAACGTTATCCGCTAAATAAACATATTTGAAATGCATGCGACCACAGTGAAAAACAAA1080 ATCACGCAAAGAGACAACTATAAAGAAATCATGTCTGCAATTGTGGGTGTCTTATTACTG1140 ACACTTACGTGATAGCCATTTTTTCGGCAATTGATCAGCTGAGTATTTCAGAAATGGGTC1200 GCATTGCAAGAGATCTTACACATTTCATTATCAATAGTTTGCAAGGCTGTAAACAAACAG1260 CAAATTATAAATATGAAATGTTAAAAAAGTATCGATAAAAACTTTATTGTTTTAAGGAGA1320 TAAAATGTCGCTCGTTTGTTCTGTTATATTTATTCATCATGCCTTCAACGCTAACATTTT1380 AGATAAAGATTACGCCTTCTCTGACGGCGAGATCCTGATGGTAGATAACGCTGTTCGTAC1440 GCATTTTGAACCTTATGAGCGGCATTTTAAAGAGATCGGATTTACTGAAAATACCATTAA1500 AAAATATCTACAATGCACTAACATCCAGACAGTGACGGTGCCTGTTCCTGCGAAGTTTTT1560 ACGTGCTTCAAATGTACCGACTGGATTGCTTAATGAAATGATTGCTTATCTCAACTCGGA1620 AGAACGCAATCATCATAATTTTTCAGAACTTTTGCTTTTTTCTTGCCTGTCTATTTTTGC1680 CGCATGCAAAGGTTTCATTACACTATTAACTAACGGTGTGCTATCCGTTTCTGGGAAAGT1740 GAGAAATATTGTCAACATGAAGCCGGCGCACCCATGGAAGCTGAAAGATATTTGTGACTG1800 CCTGTACATCAGTGAAAGCCTGTTGAAGAAAAACTTAAGCAAGAGCAAACGACATTCTCA1860 CAGATTCTTTTAGATGCAAGAATGCAGCACGCAAAAAATTTGATACGCGTAGAAGGTTCA1920 GTCAATAAAATTGCCGAACAATGTGGTTATGCCAGTACATCTTATTTTATTTATGCGTTC1980 CGCAAACATTTCGGCAACAGTCCGAAGAGAGTTTCTAAGGAGTACCGTTGTCAAAGTCAC2040 ACGGGTATGAATACGGGCAACACGATGAATGCTTTAGCTATTTGATTATTTGCTAACGAG2100 TAGTCAACCACACACGCTGCGTAAGAATTAAATGGGGCAGCCATTCCCTGCCCCGCGTTG2160 TTTTTAGGCGATATATTTATTGAAATAAATAAGTGACATCCATCACATATTTATGCACTT2220 GCATAACCTGTTGCATGATTATTTATGATCTCAATTCTGCATTTTGTCAGTAAAATGCAA2280 TAATTTATTAAATATCAATAAATTAGTTGTTTATCGGCGAGAAATTACTTAATAGAACAG2340 AAAGTAATGTCAACGCTTTATGGACTGTTTTTTCCCTTTTTTTAGCTAAATCTGCTATCT2400 CTTTATGTGACTAACTTCACTTACATCCACTTATTTCTCTTCGTAAAATTACTTTGGAAT2460 TAAGTACAATAAGAAGAGGAACATTTATGAAGTCTGCATTAAAGAAAAGTGTCGTAAGTA2520 CCTCGATATCTTTGATACTGGCATCTGGTATGGCTGCATTTGCTGCTCATGCGGCAGATG2580 ATGTAAAGCTGAAAGCAACCAAAACAAACGTTGCTTTCTCAGACTTTACGCCGACAGAAT2640 ACAGTACCAAAGGAAAGCCAAATATTATCGTACTGACCATGGATGATCTTGGTTATGGAC2700 AACTTCCTTTTGATAAGGGATCTTTTGACCCAAAAACAATGGAAAATCGTGAAGTTGTCG2760 ATACCTACAAAATAGGGATAGATAAAGCCATTGAAGCTGCACAAAAATCAACGCCGACGC2820 TCCTTTCATTAATGGATGAAGGCGTACGTTTTACTAACGGCTATGTGGCACACGGTGTTT2880 CCGGCCCCTCCCGCGCCGCAATAATGACCGGTCGAGCTCCCGCCCGCTTTGGTGTCTATT2940 CCAATACCGATGCTCAGGATGGTATTCCGCTAACAGAAACTTTCTTGCCTGAATTATTCC3000 AGAATCATGGTTATTACACTGCAGCAGTAGGTAAATGGCACTTGTCAAAAATCAGTAATG3060 TGCCGGTACCGGAAGATAAACAAACGCGTGACTATCATGACACCTTCACCACATTTTCTG3120 CGGAAGAATGGCAACCTCAAAACCGTGGCTTTGATTACTTTATGGGATTCCACGCTGCAG3180 GAACGGCATATTACAACTCCCCTTCACTGTTCAAAAATCGTGAACGTGTCCCCGCAAAAG3240 GTTATATCAGCGATCAGTTAACCGATGAGGCAATTGGCGTTGTTGATCGTGCCAAAACAC3300 TTGACCAGCCTTTTATGCTTTACCTGGCTTATAATGCTCCGCACCTGCCAAATGATAATC3360 CTGCACCGGATCAATATCAGAAGCAATTTAATACCGGTAGTCAAACAGCAGATAACTACT3420 ACGCTTCCGTTTATTCTGTTGATCAGGGTGTAAAACGCATTCTCGAACAACTGAAGAAAA3480 ACGGACAGTATGACAATACAATTATTCTCTTTACCTCCGATAATGGTGCGGTTATCGATG3540 GTCCTCTGCCGCTGAACGGGGCGCAAAAAGGCTATAAGAGTCAGACCTATCCTGGCGGTA3600 CTCACACCCCAATGTTTATGTGGTGGAGAAGGAAAACTTCAACCCGGTAATTATGACAAG3660 CTGATTTCCGCAATGGATTTCTACCCGACAGCTCTTGATGCAGCCGATATCAGCATTCCA3720 AAAGACCTTAAGCTGGATGGCGTTTCCTTGCTGCCCTGGTTGCAAGATAAGAAACAAGGC3780 GAGCCACATAAAAATCTGACCTGGATAACCTCTTATTCTCACTGGTTTGACGAGGAAAAT3840 ATTCCATTCTGGGATAATTACCACAAATTTGTTCGCCATACAGTCAGACGATTACCCGCA3900 TAACCCCAACACTGAGGACTTAAGCCAATTCTCTTATACGGTGAGAAATAACGATTATTC3960 GCTTGTCTATACAGTAGAAAACAATCAGTTAGGTCTCTACAAACTGACGGATCTACAGCA4020 AAAAGATAACCTTGCCGCCGCCAATCCGCAGGTCGTTATAGAGATGCAAGGCGTGGTAAG4080 AGAGTTTATCGACAGCAGCCAGCCACCGCTTAGCGAGGTAAATCAGGAGAAGTTTAACAA4140 TATCAAGAAAGCACTAAGCGAAGCGAAATAACTAAACCTTCATGCGGCGGATTTTTCCGC4200 CGCCTTATTGAGCGAGATAGCGATGCACGTTACAGCCAAGCCCTCCAGTTTTCAATGTAA4260 TCTCAAATGTGATTACTGTTTTTACCTTGAAAAAGAGTCGCAGTTTACTCATGAAAAATG4320 GATGGATGACAGCACTTTGAAAGAGTTCATCAAACAATATATCGCAGCGTCTGGCAATCA4380 GGTCTATTTTACCTGGCAAGGCGGTGAACCCACTCTGGCTGGCCTGGATTTTTTCCGTAA4440 AGTTATTCACTATCAACAACGCTATGCAGGCCAAAAACGTATTTTTAATGCATTACAAAC4500 GAATGGCATTTTATTGAATAATGAATGGTGTGCCTTCTCAAAGAACATGAATTTCTGGTG4560 GTATCTCGATCGATGGCCCCCAGGAGTTACATGACCGTTACAGACGCAGTAATTCAGGTA4620 ACGGTACTTTTGCAAAAGTGATAGCAGCCATCGAGCGTCTGAAATCATATCAAGTAGAGT4680 TTAATACGTTAACCGTCATTAATAACGTTAATGTCCATTACCCTCTTGAGGTTTATCATT4740 TTTTAAAATCTATCGGCAGTAAACATATGCAATTTATCGAATTGCTAGAAACCGGGACGC4800 CGAATATTGATTTCAGTGGTCATAGTGAGAACACATTCCGTATCATTGATTTTTCTGTGC4860 CTCCCACGGCTTATGGCAAGTTTATGTCAACCATTTTTATGCAATGGGTTAAAAACGATG4920 TGGGTGAAATTTTCATCCGTCAGTTTGAAAGCTT4954 (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3796 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Escherichia coli (B) STRAIN: Clinical Isolate EC- 39 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: AAGCTTAATCGCGTGAATCAGGAGTAAAAAAATGACAACCCAGACTGTCTCTGGTCGCCG60 TTATTTCACGAAAGCGTGGCTGATGGAGCAGAAATCGCTTATCGCTCTGCTGGTGCTGAT120 CGCGATTGTCTCGACGTTAAGCCCGAACTTTTTCACCATCAATAACTTATTCAATATTCT180 CCAGCAAACCTCAGTGAACGCCATTATGGCGGTCGGGATGACGCTGGTGATCCTGACGTC240 GGGCATCGACTTATCGGTAGGTTCTCTGTTGGCGCTGACCGGCGCAGTTGCTGCATCTAT300 CGTCGGCATTGAAGTCAATGCGCTGGTGGCTGTCGCTGCTGCTCTCGCGTTAGGTGCGCA360 ATTGGTGCGGTAACCGGGGTGATTGTAGCGAAAGGTCGCGTCCAGGCGTTTATCGCTACG420 CTGGTTATGATGCTTTTACTGCGCGGCGTGACCATGGTTTATACCAACGGTAGCCCAGTG480 AATACCGGCTTTACTGAGAACGCCGATCTGTTTGGCTGGTTTGGTATTGGTCGTCCGCTG540 GGCGTACCGACGCCAGTCTGGATCATGGGGATTGTCTTCCTCGCGGCCTGGTACATGCTG600 CATCACACGCGTCTGGGGCGTTACATCTACGCGCTGGGCGACAACGAAGCGACAACGCGT660 CTTTCTGGTATCAACGTCAATAAAATCAAAATCATCGTCTATTCTCTTTGTGGTCTGCTG720 GCATCGCTGGCGGGATCATAGAAGTGGCGCGTCTCTCCTCCGCACAACCACGGCGGGGAC780 TGGCTATGAGCTGGATGCTATTGCTGCGGTGGTTCTGGGCGGTACGAGTCTGGCGGGCGG840 AAAAGGTCGCATTGTTGGGACGTTGATCGGCGCATTAATTCTTGGCTTCCTTAATAATGG900 ATTGAATTTGTTAGGTGTTTCCTCCTATTACCAGATGATCGTCAAAGCGGTGGTGATTTT960 GCTGGCGGTGCTGGTAGACAACAAAAAGCAGTAATAACGACTACAGGCACATCTTGAATA1020 TGAACATGAAAAAACTGGCTACCCTGGTTTCCGCTGTTGCGCTAAGCGCCACCGTCAGTG1080 CGAATGCGATGGCAAAAGACACCATCGCGCTGGTGGTCTCCACGCTTAACAACCCGTTCT1140 TTGTATCGCTGAAAGATGGCGCGCAGAAAGAGGCGGATAAACTTGGCTATAACCTGGTGC1200 TGGACTCCCAGAACAACCCGGCGAAAGAGCTGGCGAACGTGCAGGACTTAACCGTTCGCG1260 GCACAAAAATTCTGCTGATTAACCCGACCGACTCCGACGCAGTGGGTAATGCTGTGAAGA1320 TGGCTAACCAGGCGAACATCCCGGTTATCACTCTTGACCGCCAGGCAACGAAAGGTGAAG1380 TGGTGAGCCACATTGCTTCTGATAACGTACTGGGCGGCAAAATCGCTGGTGATTACATCG1440 CGAAGAAAGCGGGTGAAGGTGCCAAAGTTATCGAGCTGCAAGGCATTGCTGGTACATCCG1500 CAGCCCGTGAACGTGGCGAAGGCTTCCAGCAGGCCGTTGCTGCTCACAAGTTTAATGTTC1560 TTGCCAGCCAGCCAGCAGATTTTGATCGCATTAAAGGTTTGAACGTAATGCAGAACCTGT1620 TGACCGCTCATCCGGATGTTCAGGCTGTATTCGCGCAGAATGATGAAATGGCGCTGGGCG1680 CGCTGCGCGCACTGCAAACTGCCGGTAAATCGGATGTGATGGTCGTCGGATTTGACGGTA1740 CACCGGATGGCGAAAAAGCGGTGAATGATGGCAAACTAGCAGCGACTATCGCTCAGCTAC1800 CCGATCAGATTGGCGCGAAAGGCGTCGAAACCGCAGATAAAGTGCTGAAAGGCGAGAAAG1860 TTCAGGCTAAGTATCCGGTTGATCTGAAACTGGTTGTTAAGCAGTAGTTTTAATCAGGTT1920 GTATGACCTGATGGTGACATAAATACGTCATCGACAGATGAACGTGTAATATAAAGAAAA1980 GCAGGGCACGCGCCACCCTAACACGGTGGCGCATTTTATGGACATCCCGAATATGCAAAA2040 CGCAGGCAGCCTCGTTGTTCTTGGCAGCATTAATGCTGACCACATTCTTAATCTTCAATC2100 TTTTCCTACTCCAGGCGAAACGTAACCGGTAACCACTATCAGGTTGCATTTGGCGGCAAA2160 GGCGCGAATCAGGCTGTGGCTGCTGGGCGTAGCGGTGCGAATATCGCGTTTATTGCCTGT2220 ACGGGTGATGACAGCATTGGTGAGAGCGTTCGCCAGCAGCTCGCCACTGATAACATTGAT2280 ATTACTCCGGTCAGCGTGATCAAAGGCGAATCAACAGGTGTGGCGCTGATTTTTGTTAAT2340 GGCGAAGGTGAGAATGTCATCGGTATTCATGCCGGCGCTAATGCTGCCCTTTCCCCGGCG2400 CTGGTGGAAGCGCAACGTGAGCGTATTGCCAACGCGTCAGCATTATTAATGCAGCTGGAA2460 TCACCACTCGAAAGTGTGATGGCAGCGGCGAAAATCGCCCATCAAAATAAAAACTATCGT2520 TCGCTTAACCCGCTCCGGCTCGCGAACTTCCTGACGAACTCTGCGCTGTGGACATTATTA2580 CGCCAAACGAAACGGAAGCAGAAAAGCTCACCGGTATTCGTGTTGAAAATGATGAAGATG2640 CAGCGAAGGCGGCGCAGGTACTTCATGAAAAAGGTATCCGTACTGTACTGATTACTTTAG2700 GAAGTCGTGGTGTATGGGCTAGCGTGAATGGTGAAGGTCAGCGCGTTCCTGGATTCCGGG2760 TGCAGGCTGTCGATACCATTGCTGCCGGAGATACCTTTAACGGTGCGTTAATCACGGCAT2820 TGCTGGAAGAAAAACCATTGCCAGAGGCGATTCGTTTTGCCCATGCTGCCGCTGCGATTG2880 CCGTAACACGTAAAGGCGCACAACCTTCCGTACCGTGGCGTGAAGAGATCGACGCATTTT2940 TAGACAGGCAGAGGTGACGCTTGGCTACAATGAAAGATGTTGCCCGCCTGGCGGGCGTTT3000 CTACCTCAACAGTTTCTCACGTTATCAATAAAGATCGCTTCGTCAGTGAAGCGATTACCG3060 CAAAGTGAGCGCGATTAAAGACTCAATTACGCGCCATCAGCTCTGGCGCGTAGCCTCAAA3120 CTCAATCAAACACATACCATTGGCATGTTGATCACTGCCAGTACCAATCCTTTCTATTCA3180 GAACTGGTGCGTGTCGTTGAACGCAGCTGCTTCGAACGCGGTTATAGTCTCGTCCTTTGC3240 AATACCGAAGGCGATGAACAGCGGATGAATCGCAATCTGGAAACGCTGATGCAAAAACGC3300 GTTGATGGCTTGCTGTTACTGTGCACCGAAACGCATCAACCTTCGCGTGAAATCATGCAA3360 CGTTATCCGACAGTGCCTACTGTGATGATGGACTGGGCTCCGTTCGATGGCGACAGCGAT3420 CTTATTCAGGATAACTCGTTGCTGGGCGGAGACTTAGCAACGCAATATCTGATCGATAAA3480 GGTCATACCCGTATCGCCTGTATTACCGGCCCGCTGGATAAAACTCCGGCGCGCTGCGGT3540 TGGAAGGTTATCGGGCGGCGATGAAACGTGCGGGTCTCAACATTCCTGATGGCTATGAAG3600 TCACTGGTGATTTTGAATTTAACGGCGGGTTTGACGCTATGCGCCAACTGCTATCACATC3660 CGCTGCGTCCTCAGGCCGTCTTTACCGGAAATGACGCTATGGCTGTTGGCGTTTACCAGG3720 CGTTATATCAGGCAGAGTTACAGGTTCCGCAGGATATCGCGGTGATTGGCTATGACGATA3780 TCGAACTGGCAAGCTT3796 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5541 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Escherichia coli (B) STRAIN: Clinical Isolate EC- 625 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: AAGCTTAAGCCTGCATTTGCTCAATGAAGCGCAGAATGAGCTGGAACTGTCAGAAGGCAG60 CGACGATAACGAAGGTATTAAAGAACGTACCAGCTTCCGTCTGGAGCGTCGGGTCGCCGG120 AGTGGGTCGTCAAATGGGCCGCGGTAACGGCTATCTGGCAACCATCGGCGCGATTTCTCC180 GTTCGTTGGTCTGTTTGGTACGGTCTGGGGCATCATGAACAGCTTTATTGGTATCGCGCA240 AACGCAGACCACTAACCTGGCAGTCGTTGCGCCGGGTATCGCAGAAGCTCTGTTAGCAAC300 GGCAATCGGCCTCGTGGCAGCGATTCCTGCGGTCGTTATCTATAACGTATTTGCACGCCA360 GATTGGCGGCTTTAAAGCGATGCTGGGTGATGTTGCAGCGCAGGTATTGTTGCTGCAAAG420 CCGTGACCTGGATCTGGAAGCCAGCGCCGCTGCGCATCCGGTTCGTGTCGCACAAAAATT480 ACGCGCAGGATAATATCCGATGGCAATGCATCTTAACGAAAACCTCGACGATAACGGCGA540 AATGCATGATATCAACGTGACGGCGTTTATCGACGTGATGTTGGTTCTGCTGATTATCTT600 TATGGTGGCGGCACCGTTAGCGACGGTAGATGTGAAGGTGAACTTGCCTGCTTCTACCAG660 CACGCCGCAGCCGCGGCCGGAAAAACCGGTTTATCTGTCGGTGAAGGCAGACAACTCGAT720 GTTTATCGGTAACGATCCGGTCACCGATGAAACAATGATTACGGCGTTGAATGCGTTAAC780 CGAAGGCAAGAAAGACACCACCATCTTCTTCCGAGCGGATAAAACCGTCGATTACGAGAC840 GTTGATGAAGGTAATGGATACGCTGCATCAGGCGGGTTACCTGAAGATAGGTCTGGTCGG900 CGAAGAAACCGCCAAAGCGAAGTAAAGTAGAATTGCCTGATGCGCTACGCTCATCAGGCC960 TACAAAATCTATTGCAACATGTTGAATCTTCGTGCGTTTGTAGGCCGGATAAGGCGTTCA1020 CGCGCATCCGGCATTAGGTGCTCAATGCCTGATGCGCTACGTTTATCAGGCCTACAAAAT1080 CTATTGCAACATGTTGAATCTTCATGCGTTTGTAGGCGGATAAGGCGTTTTCGCACATCA1140 GGTAAGAGTGAATTCACAATGATGCCCGGTTGCTTTTCACAACCGGGCATTTTTTTAACC1200 TAAATGCTCGCCGCCGCACACACCGTGCACTTCTGCGGTGACGTAGCTCGACTCCTGACT1260 TGCCAGATAAACATATACTGGGGCCAGTTCCGCCGGTTGCCCCGCACGCTTCATCGGCGT1320 TTTCTGACCAAACTGCGGGATCTTATCCTGCGTTTGTCCGCCGGAAATTTGCAGTGCCGT1380 CCAGATAGGGCCTGGCGCGACAATATTCACCCGAATACCTTTCTCCGCGACCTGTTTTGC1440 CAGGCCACGGCTGTAGTTCAGAATCGCCGCCTTCGTAGCCGCATAGTCCAGTAAATGCGG1500 ACTTGGCTGGTATGCCTGGATTGACGAAGTGGTGATAATACTTGCACCTTTCGGTAGCAG1560 GGGGATCGCTTCCTGGGTTAGCCAGAACAGCGCGAAAACGTTAATGGCAAAGGTCTTTTG1620 AAACTGTTCGCTGGTGAGGTCTGCAATATCAGGAATGGCAACCTGTTTCCCGGCGACCAG1680 CGCCATAATATCCAGCCCGCCTAACGCCTTGTGCGCTTCGTGAACCAGCGAACGGGCGAA1740 TTTCTCATCGCTTAAATCGCCTGGCAGCAGAACGGCTTTGCGTCCGCATTCTTCAATGAT1800 CTTTTTCACATCCTGAGCGTCTTCTTCTTCCACGGGAAGATAACTGATCGCCACGTCAGC1860 CCCTTCACACGCGTAAGATGGCGGCAGCGCGACCGATTCCGGAATCGCCCCCTGTCACCA1920 GTGCTTTACGATCTTTCAGGCGACCGCTACCAACATAGGTTTTCTCGCCGCAATCCGGTA1980 CCGGTGTCATCTTCGCCTGGATGCCTGGCGTCGGTTGTTTCTGTTTGGGATATTCACCAG2040 TGTAATACTGCGTGGTCGGGTCTTTTAAATGAGACATCGTTTTTCTCCCTTCAGGTTCAA2100 CGTCCTTTAAGGGTAGACGCTCTCGATGCGTTGATAAGGGAACCAGGAAGATCCCTAACC2160 CTCAGAATTATGCGACAAAGGTTTAACGGATATGTTGATTTGCTGTTGCGCGCTGTTTAC2220 TCAATTGCGATATACTGTTGCCCGTTTTAACTACACGACAGGAATGTATGGAACGTTTTC2280 TTGAAAATGCAATGTATGCTTCTCGCTGGCTGCTTGCCCCCGTGTACTTTGGCCTTTCGC2340 TGGCGTTAGTTGCCCTGGCGCTGAAGTTCTTCCAGGAGATTATTCACGTACTGCCGAATA2400 TCTTCTCGATGGCGGAATCAGATTTGATCCTCGTGTTGCTGTCGCTGGTGGATATGACAC2460 TGGTTGGCGGTTTACTGGTGATGGTGATGTTTTCCGGTTATGAGAATTTCGTCTCGCAGC2520 TGGATATCTCCGAGAACAAAGAGAAGCTGAACTGGCTGGGGAAAATGGACGCAACGTCGC2580 TGAAAAACAAAGTAGCAGCGTCGATTGTGGCAATTTCTTCCATTCACTTACTGCGCGTCT2640 TTATGGATGCGAAAAATGTCCCTGATAACAAACTGATGTGGTACGTCATTATCCATCTGA2700 CGTTTGTGCTCTCTGCATTTGTGATGGGCTATCTTGACCGACTGACTCGTCATAATCACT2760 GATCTTATGCGGGCGCGGTTCTCGCGCCCGTTATTAACAGGTCATTTATCGGAAGACGCC2820 TGCCACAGATTCAGCTCGCCATCGGCGATATGCTGATCAATCTGCGCCAGCTCCTCGGTG2880 CTAAATGTCAGATTATTCAGCGCCTGCACGTTCTCCTCAAGTTGTCCGCGCGGCTGGCAC2940 CAATCAATACCGACGTCACGCGATCATCTTTCAGCAACCAGCTTAACGCCATTTGCGCCA3000 TTGATTGTCCACGCTGCTGTGCCATTTCATTCAATAAGTGTAGGCTGTTGAGGTTGGCTT3060 CGGTAAGCATTTTCGGCGTCAGACCACGAACTTTATTCCCTTCACGATGCATCCGTGAAT3120 CTTGCGGAATGCCGTTGAGATATTTTCCGGTCAGCAATCCCTGAGCCAGAGGAGTAAAGG3180 CAATACAGCCCACGCCGTTATTTTGCAGGGTATCCAGCAGGCCGCTTTTATCCACCCAGC3240 GGTTCAGTAAATTGTACGAAGGTTGATGAATTAACAGCGGAATTTTCCACTCGCGCAGCA3300 ACTCAACCATTTTTTGCGTCCGCTCTGGCGAGTAAGAGGAGATCCCGACATAAAGCGCCT3360 TACCGCTTTGTACCGCATGAGCCAGCGCAGAGGCGGTTTCTTCCATCGGCGTATTTTCAT3420 CGACGCGATGAGAGTAAAAGATATCGACATACTCAAGCCCCATACGCTTCAGGCTTTGGT3480 CGAGGCTGGAGAGCAGGTATTTACGTGAACCGCCAGAGCCGTAAGGGCCGGGCCACATAT3540 CGTAGCCAGCCTTGGTAGAGATAATCAGTTCATCGCGATAAGCGGCAAAATCCTCCCGCA3600 GCAGGCGACCAAAGTTCTCTTCTGCGCTTCCTGGAGGCGGCCCGTAATTGTTGGCTAAAT3660 CAAAGTGCGTAATGCCTAAATCAAACGCTTTACGCAGGATTGCACGCTGTGATTCCAGCG3720 CGTTAACGTGACCGAAATTGTGCCATAAACCGAGCGATAACGCGGGCAGGCGTAAACCAC3780 TTTTTCCGCAATAGCGGTACTGCATCTGCCCGTAACGTTCGGGTTCGCTAACCAGACCAT3840 GACCTCTCCTTTCCACCGTTCAATTTCGAAACAATGTTTCTAGTTTAGCGATTCGCCAGC3900 GCGTATCCCGTAGTCTGGCTCACAGAGTGACGAAAAATTGGCAAAAACACGCGCTTATGC3960 TTTGCTTAAAAAAACACCAGTTGAGGAGTGCAACGATGCCGCGTTTAACCGCCAAAGATT4020 TCCCACAAGAGTTGTTGGATTACTACGACTATTACGCTCACGGGAAAATCTCGAAACGTG4080 AGTTCCTCAATCTTGCGGCGAAGTATGCGGTGGGCGGGATGACGGCATTAGCGTTGTTTG4140 ATTTGCTCAAGCCAAATTATGCGCTGGCGACTCAGGTAGAGTTTACCGACCTGGAGATTG4200 TTGCTGAGTACATCACGTATCCTTCGCCAAATGGTCACGGCGAGGTACGGGGTTATCTGG4260 TGAAACCCGCAAAAATGAGCGGCAAAACGCCAACCGTGGTGGTGGTGCATGAGAATCGTG4320 GACTGAATCCGTATATCGAAGATGTGGCACGGCGAGTGGCGAAGGCGGGGTATATCGCCC4380 TGGCACCTGACGGCTTAAGTTCCGTTGGAGGTTATCCGGGAAATGATGATAAAGGTCGTG4440 AGCTGCAACAGACAGGTTGATCCAACCAAACTGATGAATGATTTCTTTGCCGCAATTGAG4500 TTTATGCAACGCTATCCGCAAGCGACAGGCAAAGTGGGTATTACCGGATTTTGCTATGGC4560 GGTGGCGTATCGAACGCGGCGGCTGTCGCGTATCCGGAACTGGCCTGCGCGGTGCCGTTT4620 TATGGTCGTCAGGCACCCACTGCCGATGTGGCGAAGATTGAAGCGCCTTTACTACTCCAC4680 TTCGCGGAACTGGACACCCGAATCAACGAGGGCTGGCCTGCTTACGAGGCGGCGTTGAAA4740 GCCAATAATAAGGTTTATGAGGCGTATATCTATCCGGGGGTTAATCACGGATTCCATAAT4800 GATTCCACGCCCCGTTATGACAAATCTGCCGCCGATCTTTCCTGGCAAAGGACACTGAAA4860 TGGTTCGATAAATATCTCTCCTGATAGGTTTATCTCTTACGGGATTACGTCTTAAACAAG4920 CATGAAAAAATAGCGTGCGCAAAAGTCGTTCTTTGCCTAAAATATCGCTATATATAACAA4980 TATATAGCGAATGAGGTGAACGATGAATAACCATTTTGGTAAAGGCTTAATGGCGGGATT5040 AAAAGCAACGCATGCCGACAGTGCGGTTAATGTGACAAAATACTGTGCCGATTATAAACG5100 CGGTTTTGTATTAGGCTACTCACACCGGATGTACGAAAAGACCGGAGATCGCCAGCTTAG5160 CGCCTGGGAAGCGGGTATTCTGACGCGCCGCTATGGACTGGATAAAGAGATGGTAATGGA5220 TTTCTTTCGTGAGAATAATTCCTGTTCTACGTTGCGCTTTTTTATGGCCGGTTATCGCCT5280 CGAAAATTGATCAAACATACGTATTATCTTGCTTTAATTAATTACACTAATGCTTCTTCC5340 CTTCGTTTTAGCGCCCCGCCGCAGTATCATGATATCGATAACCATAATAAATGTGTGGTA5400 AATGGCGCATCGATCGCATTATTGATTTTGCGATTGAGGCAAAATATATGCCAGGTCTTC5460 GCAACGGAATAACTATAAATGACTGGAGATAACACCCTCATCCATTCTCACGGCATTAAC5520 CGTCGTGATTTCATGAAGCTT5541 (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6317 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Enterobacter cloacae (B) STRAIN: Clinical Isolate ET- 12 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: AAGCTTGCCCGCATCATTCAGGAGCAGGGGCGTCGCGACCAGTTAGGTGTGAAGTTTGGC60 AGCGGTGACAGCCCGGACTGCCGGGGGATCACGGTTCCGGAACTGCAGAGTATCGACTTC120 GACAAAATCAACTTCTCTGACTTCTACGAGGATTTGATGAAGAACCAGAAAATCCCCGAT180 ACCAGCGCGCAGGTCAAGCAGATTAAGGATCGCATCGCCGCGCAGGTGAACCAGCAGGGA240 GGTGGCAAATGAAGCGTGTCCTCTGTGGCCTGCTTATGGCGCTGGCGAGCCATACGGCAC300 TGGCCGATGAGATTGTGACGCCGGCTGAGCCGTTCACCGGCTGGTCCTGGTACAACGAAC360 CGAAAAAGCCCCCTGAGCAGCCCCGGAAACCGCAGCAGCCAGCACCGCAGCCATTCCGGA420 TCTCAGCAAAATGTCCCCGATGGAGCAGGCCAGGGTGCTGAAAGGGTATACACAGGAGGC480 GCTTAACCGCGCCATCCTGTACCCCTCAAGGGAAAACACGGCGACGTTCCTGCGCTGGCA540 GAAGTTCTGGACGGACCGGGCATCGATGTTCAGCCAGTCCTTTGCGGCGGCGCAGCTGAG600 CCATCCGGACCTCGACTACAACCTGGAGTATCCGCACTACAACAGCATGGCGCCGTTTAT660 GCAGACCCGTGACCAGCAGACGCGGCAGAGCGCCGTGGAGCAGCTTGCGCAGAGTACGGT720 CTGTTCTACTTCTACCGGGGCAGTGACCCGATTGATGTGCAGATGGCGGGCGTGGTGGCT780 GACTTTGCGAAAACCAACGGGATCTCACTCATTCCGGTCTCGGTTGACGGACAGGTGGCG840 GCCACCCTGCCGCAAAGCCGTCCGGACACCGGACAGTCCCGGTCGATGAATATCACGCAC900 TTTCCGGCGCTCTTCCTGGTTGACCCGCGCAACCAGAACTACCGTGCCCTGTCCTATGGC960 TTCATGACCCAGGATGACCTGTCAAAACGATTCCTGAACGTGGCCACCGGCTTTAAACCC1020 AATTCCTGAGAGCCTTTTATGACAAAAACACTGTTTACCTCATCCGCGATGCAGGGCGGG1080 CTGCCCTGTATTCCTTCGTCCTCGGCCCGGCACTGGTGCTGTATGTGTTTGTGATGCTGG1140 CGGCATCAGACGGCTCACTTTCCCGGCAATTCCTGACGACCTTTCATCACCTGACTGAGG1200 GTGCGCCTGCCGGCAAGGTGATGGGATGTGTTAATGAACATGAGATGGCAGGGCGTTTCT1260 CGCCACCTGAACCCGGAGAGTCGTTAAAGCCCGTGCCTTCCGTTTTAGATAAAGCACCGC1320 CTGAAGTGTTATGTCAGCTCGGGCCCGTTGACAGCGATTCGTGGGCGCGTACGACAGATG1380 CAACGTTGCTCAACACCTGGATTATCTCGGTGATGTTTGGCTTTGGTGTGTGGTTTGTTT1440 TATATGGCCTGTCCCGGGCCGCTCAGCGTCGCATTTCACCAGACACACATTCTGTACTGG1500 TACGGCAGAACAAGGAGACACAGGAATGAAACCAACTCTTCTCGCAGGACTGATTTTCTG1560 GGGCATGATGGCGCGCCGTACTGAGCGAGCTGATGACCTGGTCCGTGGAGCATACACAGC1620 AGGGCCTGCTGTGGCTGTGCAATGGGATGTGGGCCGGGGCGGCTGGCATGGTGATTTATG1680 CAGGTTATCGCTGGTACCGTGACGAAAGAGGGCAAACGCATAAGGAAGGCGATCATGAAC1740 ATTAAAACCGGACTCACGGCTCTGCTGATGTGCCTGCCCCTGCTGGCGAACGCGGGGGCG1800 CGCGAGGAGTTAATGGCGCTTGAAGCGACAAAAACAACCTCTGCTGACGCTGCAGCCATC1860 ACCGCCTCCACCATTCCGGTACCTGCGCCGGCCAGCCTGATGGCGCTGCCGGACGGACGT1920 CGGGCTAACATGAAAGATTATGCCGTGGTGCTTTTTATGCAGGCACACTGCCAGTACAGC1980 GCGAAGTTTGACCCGCTGCTGAAGGGCTGGGCTGATGAGCATTCTGTCAGGGTTTATCCA2040 TACACCCTGGACGGCGGCGGTGATGTGTCTTACCGACGCCGATGATCCCGCGCAAGACGG2100 ACCCGAATTCTCCCATTGCAGACGAGATTGTCACCTTCTTCGGAAACGGGCTGCCGATTG2160 CGACACCAACGGCCTTTATGGTCAACGTTAACACCCTGAAAGCCTACCCGCTGACCCAGG2220 GTGTGATGGACATCCCCGCTCTTGAGAGCCGTATGGCCAGCCTGATTCAGGCTGACATGG2280 ACAACGTCGATCCGAAAACGCTGCCGCCCATGCCGGCAAGTGCGCAGGTCACCCCTCAGT2340 AATACAAACGGACTACAAAATGACGACAAATACGTATGCGTTATCGCGTACCGAGCGCGT2400 GTGGCTGTTATTCAGCGTGACGCTGCTTGTGTCCGCAGCTTTCTATGGGGTACTGGCCCA2460 CCGGGTGGTCAGCGTCTGACCGTCAGACTGACAACTGTTTGCAGGACTTTCCGGTGCTCC2520 TGCTTATCTCGCTGAGTATCGGATTCTTTTTCACCGTCACCGGGCTGTACGTCTGCCGGC2580 AGACCCTGGTCAGGAAACCCCGGGAGGAGATTGCATGAGGCACATCAGACTGAAGACGTT2640 TATCCGAAACCAGGCTATCGGGATACTGAAAGACAGTAGTGAGGATACGGAAACCCGAAA2700 ATGGACGGATTTGTTAACCCTGAAACTGTTTTTATGCCTTAATTTTTACCGCCGTAGTCG2760 AAAGGGTATACGTGAAGTGCGCCATCACAACGCTCAGTGCGATCTCCGTTGACCGCTCCG2820 AACAGTTTACGCTCTCGCTTCTCATCCACTATCCACAGTACCTGTTGTGGGGCGTTATGG2880 CCGCGATTATCGCGCTCATTGCGGTGAATTTACTCGTCTGCGGCTGGTTCTGTCTGGCCA2940 CATATCTTTGCCGCAAACTGAACCGGACTGACATCCCGGCAGGCAAGGATATGCAAGCTG3000 TGGAGGTGCCTAATGATTAAGGCGCTTATTACGGCAGGGGTTGTGTTCTTCTCAGGTCTG3060 GCAGCGCTGCCTGCTCAGGCGGACGTCAATGGTGACTCAACGGCTTCTTTGGCAAGCTGG3120 GCTACAGCGGCAACGTCTCTCAGGCGCAGGCCTGGCAGGGGCAGGCGGCCGGGTATTTCT3180 CCGGCGGGTCGGTCTACCTGCGAAACCCCGTCAAAAACGTTCAGCTGATCTCGATGCAGC3240 TGCCGTCCCTGAACGCCGGCTGCGGCGGTATCGATGCCTACCTGGGGTCATTCAGCATGA3300 TCAGCGGTGAGGAAATTCAGCGATTCGTGAAGCAAATCATGAGTAACGCGGCTGGCTATG3360 CATTCGACCTGGCACTGCAGACGATGGTCCCGGAGCTGAAGCAGGCGAAAGATTTCCTGC3420 AGAAGCTGGCCAGTGATGTTAACTCCATGAACATGAGTTCGTGCCAGGCCGCTCAGGGCA3480 TCATAGGCGGGTTGTGGCCCGTAACGCAGGTGTCACAGCAGAAAATCTGCCAGGACATTG3540 CCGGCGAAACCAACATGTTTGCTGACTGGGCGGCCTCCCGCCAGGGCTGCACCGTCGGAG3600 GACAGGGGGATAAAGTCACGGCCAAAGCCGGCGACGCAGAAAAAAGACCCAGGTACTGAA3660 AAACAAAAACCTTATCTGGGACACGCTCAGTAAGAACGGGCTGCTTGGTAACGATCGCGC3720 CCTGAAGGAGCTGGTCATGAGTACTGTCGGCTCCATCATTTTCAACAAAACCGGAGACGT3780 GACATCCTGACGCCGCTGGTCGATACCGCGACCTGATTAAAGTTCTGATGCGCGGGGGAA3840 CAGCGAAGGTCTACGGGTGCGATGAGGCAACACTCTGTCTGGGGCCTGTCGTTACTAACC3900 TGACGATTACTGAGTCCAACGCTCTGGTCACACTGGTCAAAAAACTGATGCTCTCGATGC3960 AGAACAAACTTGTCGATGACAAACCGCTGACCGATCAGGAAAAAGGCTTCGTGAACACCA4020 CCTCTGTGCCGGTACTGAAATACCTGACCAACGCCCAGAGTATGGGGATGAGCGCCACGT4080 ACCTCCTGCAGGTTTCCGACTTCATCGCGCAGGACCTGATGATCCAGTACCTCCAGGAAC4140 TGGTGAAACAGGCAAGCCTGTCTCTGGCTGGTAAGAACTTCCCGGAAGAGGCCGCTGCGA4200 AGTGCGCGACAACATCATTCATGCCCAGGGACTGCTGGCCGACATGAAGCTGCAGTCTGC4260 GGCAGACCAGAACGCACTGGACGGCATCGACCGCAACATGCAGTACTGCAGCAGCAGGTG4320 TCCACCATTGTTTCAGGCTCCTATCAAAGCAACTATCACTGGGGTGATCGCTGATGCTTG4380 AGATATACACCATTTATGGCGGGGGAATGTGGAAAAACGCGCTGGACGCCGTTGTCACCC4440 TTGTCGGTCAGAATACCTTCCACACCTTAATGCGTATTCGCCCGGCACCTTCGGGGTGCT4500 GGCTGTATTGCTCACTTTCATCAAACAACGTAACCCGATGGTCTTCGTCCAGTGGCTGGC4560 GATCTTCATGATCCTGACGACCATCCTGCTGGTACCGAAACGTTCAGTACAGATAATTGA4620 CCTCTCAGACCCCGGCTGCGGTGTGGAAAACCGATAATGTACCGGTCGGTCTGGCTGCCA4680 TCGCGTCACTGACGACCAGCATCGGTTACAAAATGGCATCGGTGTACGACATGCTGATGG4740 CCAGACCTGACTCGGTAACCTACAGCAAGACCGGTATGCTGTTTGGCTCGCAGATTGTGG4800 CGGAAACCAGTGACTTCACCACGCAAAACCCGGAACTGGCTCAGATGCTGCCGGACTACG4860 TGGAAAACTGTGTGATCGGCGACATTCTGCTGAACGGTAAATACACCATCAATCAGCTGC4920 TCAATTCCACTGACCCGCTGACGTTGATAACCAGTAACCCAAGCCCGCTGCGGGGCATCT4980 TTAAGATGACCTCCACCTCGCGCCAGTTCCTGACCTGTCAGCAGGCGGCAACGGAGATTA5040 AGACGCTGGCGAATACCGACGTCAATCCGGGCAGTGCGACGTTCACCTGGCTGACGCGGA5100 AGGTATTCGGCAACAAGCTGAATGGTGCCTCGCTTCTGCCAACGCTATGGGTGAGAGCTA5160 CGGATTCTTCTATGCCGGGGGAATGACGGCTGCGCAGATCATGAAGAACAACATCACGAA5220 CAGTGCAGTTCGGCAGGGGATTAAGGGTTTCGCCGCTCGCTCATCCGACACGGCTAACCT5280 GCTGAACCTGGCCACCGAGAACGCTGCAACCAAACAGCGTCTCAGCTGGGCTGCGGGTAA5340 TGAGCTTGCCACCCGAACTCTGCCGTTTGCACAGTCCCTGCTGATGCTTATCCTGGTGTG5400 CCTGTTCCCGTTGATGATTGCGCTGGCCGCATCAAATCACACTATGTTTGGGCTGAACAC5460 CCTGAAAATATACATTTCCGGTTTTATCTATTTCCAGATGTGGCCGGTGATGTTCGCCAT5520 CCTTAACTATGCTGCCAACTACTGGCTGCAGAGTCAGTCCGGGGGCACGCCTCTGGTGCT5580 GGCCAACAAGGATGTAGTGGCACTGCAGCATTCGGACGTGGCGAATCTGGCAGGGTATCT5640 GTCGTTGTCCATTCCGGTGCTGTCGTTCGTATCTGACCAAGGGGGCTGCGGCGATGGGCT5700 CTCAGGTGGCAGGCAGTGTCCTCAGTTCGGGCGCCTTCACGTCGGCAGGTGTGGCAGCAA5760 CCACGGCGGACGGGAACTGGTCGTTTAACAACATGTCAATGGACAATGTCAGCCAGAACA5820 AGCTGGATACCAACCTGATGCAGCGTCAGGCCAGCAGACGTGGCAGGCAGATAATGGTTC5880 CACGCAGACGCAGACGCCGGTGGCCATACGGTATCGACGGCTCAGGCGCAATGTCGAATC5940 TGCCGGTGAACATGAAGCTCAGCCAGCTGGCCAGCAGTGGTTTCCAGGAGTCTGCCCGCC6000 AGTCGCAGGTCCAGGCGCAGACGGCGCTCGATGGCTACAACCACAGTGTCACCAGTGGCT6060 GGTCGCAGCTCTCACAGCTGTCTCACCAGACCGGTACCAGCGACAGCCTGACCAGCGGCA6120 GTGAAAACAGCCAGGCCACTAACTCAACGCGCGGCGCGAGCATGATGATGTCGGCCGCTG6180 AAAGCTATGCGAAAGCTAACAATATCTCGACGCAGGAAGCCTATAACAAGCTGATGGATA6240 TCAGTAATCAGGGTTCTGTATCTGCAGGCATTAAAGGTACGGCCGGAGGGGGACTTAATC6300 TGGGCGTTGTTAAGCTT6317 (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6914 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Enterobacter cloacae (B) STRAIN: Clinical Isolate ET- 49 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: AAGCTTTTCGAGTTCGCCATCCGGCAACAGCTCACTGAGCTTTTACGCGCCCAGGGTGCC60 TTTGAACTCAATTCCCAGCTCAGTAAGGCGGTCCTGAATAATCTCTTTGCGAGATTTTTC120 ACTGGTACCGGCATCAGGTGTTGCAGGTTTCAGCTCGCCACCAGCCTCGCCCTTCATCAG180 CCGGACGTTAGACTTCAGCGCCGGGTGAAGATCTTTCAACTCCACCACGTCGCCAACCTT240 TACGCCGAACCATGGGCGCACAACTTCGTATTTAGCCATGCTGTTTCCTTACGCCAGGTT300 AGCGCCGTAGACAACGCCAGACAGGCCTGATCGTCTGCAGTAATTTGCAGGCCTTCAGCA360 GACATGATCTGGAAGTTGTAGTTAACGTTAGGCAGTGGGCGCGGCAGTGGCACAACGCCA420 ACAGCCATACCCACCAGTGGGGAGATCACGTCACGACGACGAACGTACGCGATAAACTCG480 TTACCGGTCAGCGCGAAGTCATGCGGATTTCTTTCACCGGTGCGAATGGCAGAACAGCCT540 GCAGGAGAGTGCCGCTCACCACACCATTAACTACGTATGGCTGAGCCATATTTGCCCAGA600 TCTCAGGGGAAACCCACATCACATCATACTGAGCTACTTTGTTGGTGCGTGCGGTGGTAC660 CGAATGCTCCTTTACCAAAGAACTCAAAATATTGAGTCGTGGTTGCGCTGGTCAGGTCGA720 TGTTCGCACCACCAGCACCAGAACCGAGGTTAATCTTCTTGGTGTTGCGGTGGTTCTTGA780 TGCCCTGCGCCGGGTAGGACTGAACCTGAATTTTTGAATCGCCGTTCAGGTAGTAGTTGA840 CGCGCTTCTGGTTGAACTTGCGCATCTTCGCCATCTGCGAATCCAGAACCAGATCAATGC900 CTACAGAGTTAAGGCCAGCAGCATGACGCCAGTTAACACCGTAGCCAGCAGTGAACACCG960 GAATCGGGTCGCCATCGCTCGCGTAGTCAGTGTGGTCGAAGGAGAATGGCGCCTGACCAT1020 CGATGCTTACTGACACGTCGTCAGCGATGTCGCCGACCACGTTATACAGCTTGGCGGTTT1080 TACCAACCGGCAGCACGGTCTGAACGCCGATCAGGTCGTTTACGATTTCCATGCCAACTT1140 CCTGATCCCGCAGCTGCAGCACCTGGTTGTCAATCTCAGCCCAGAAGTCACGGGAGAAAC1200 CGCCAACAGCGTTACAAGCCAGCATGTCAGGCGTCATCATTGCGCGGTTAGCTGCAATGA1260 TGGAATCGTTCTGTAGGTTCCACATGTTGCGGTTTGCCCACAGCTCACTCCAGTGCCCGC1320 CGAGGCGGGAGTTAGTCGCCAGCGTCTCTTTAGAGAAGTACATATGTGTTTGTCCTTTTG1380 TTACGCGCCAGCTGCGGCGACAGTGCCAACGCGCATACGCACGCGAATGAAGTCAGTGGT1440 GCTGGCCGCGATGGTGTATTCATCCTGGCTGTAGCCGATCACTGAATCAGTGTCGGATGT1500 GGCAAGGGTAAACTGACCGGCAGTTCCCAGCTTGATCGGGCTGTCTTTTTTATACGCACC1560 AGGCAGGCAGCGCAGCGCCAGCTCACGACCTTCTTCGACGTAGTTACCTACTGCCGAATC1620 CCCGGCAGGGATTTCTTCGGTGATTGTCAGGCCCTGGTGATAACCGACATCGATGATGTA1680 CAGGCGGCCGGTTAGCGCGGTGGCCTGAGCGAATTTATCGGATGAGTTGATGGTTGCGGC1740 GGTGCCAGGAAGCAACCCGGCGGCCGTTGTGCGGGTTTCGGTCTTGTACAGAGACTGACC1800 GTCGATATTAACGCGACGATAACGTGGCATTATTCCGGCTCCTTACTTGAAGTGTTCGTC1860 TGCGGCTGGTGCGCCGGTTTCTTTGTGCTGCTGAGCATTGTTGGTGCCCAGCGACTTGAA1920 CATCGCGTCCAGAGCTTCGCCTGACAGAGCGTTCGCGAGCGATATCGCCATGGACCTTCG1980 CAACCGCTTCGCGCTTTGCTTTCTCTTCGGCACGGGAGTTCGCGGTAAGGGTTTCCGCGA2040 GTTGCTTCTGATTGGCCTGCAGCGCATCAACCTTTTCCGCGAGAGGCTTAATAGCCGCTT2100 CAGTATTGGTCGCAACAGCCTGGCCGATCATGCTGCCGATTTGTTCCAGTTCTTCTTTGG2160 TTAAAGGCATGTCGCCTCCGTTTTGTGGTTTGGTGCAGGCTGTTCCTGCGGTGTGAATAG2220 AGCTTTGAATTGTTAGCGACGACTGCCACCCACGACTCCTGGCGCGCTACTGCGGTTCCG2280 GTATCGTCGATTGTGATCTTCCCGCCATCAGCGAATACCGTAAACCTGAGCATCACCGCC2340 ATTTCGCACGATGACCACCTGCGAGTCAGTGAGTCAGCAACCCAGGCATATTCATCCGTG2400 CCCGGCGCAAACTTGGCTTTGGCTGCCCGATCGAGACGCTGCTCGCGCTCCCGGTAGGAT2460 TCACCCACCAGCGCGCCGGAGTTCGCTTTAAGCGGCTGCGCCAGATCGGCGTTTACCATC2520 AGGCCAACGCCCTGCTCAGGGGTGGCGGCTCCGACTTCGTGCAGTAGGATCGCGTCGTGG2580 TCCATGCTGTGAATCTTCGCCACCCACTCGGCACCCGTAGCTCTCTGTTGTTCGTTAGGC2640 TCAAGCTGGTCGAGGAAAGCGGCGACACTGGTATGAATCGGCGGAACGTCATCGCCGCGC2700 TCGATGGCTGCGACGCGCTCAAGTAGTTCTCGGCCACCTTCAGACTCACCGGCGCGGGCA2760 ACATCAACCCACTTTTCGAGGTAGATACGATTACCGGACTTCTTAACGTTGCGGTTCCAC2820 GCGCCGATATGGCCTGCGTTAATCCCCTCCGGGGAGAAAGCAGACACGAACTGACCATTA2880 ACCTGAGGGTGGCCCAGCGGCGCCAGGGTACCTTCCAGCCCCTTATAGTGGGCGTCGATT2940 TGCTCTTGCGTGTACAAGCCGCCATTCATGACGACGTTAGCTGGAAGTGTGTAGCTCGGC3000 AGCACCAGGTGCTCACGCCCGTTGTATGTTTCGCGCCGGATAGACTGGCTGTTCACCTTT3060 GTGGTGATGTTGACCTGAATATGCTCACCATGTTTCGGTGCCTGGATTGGACGCTGTGCT3120 TCGTGGTTTACCTGGAATTTCATGAGTTATTTCTCCGCCCAGGCGTAACCGCTCGCCTGC3180 ATCGATTTATATTCCTGTTTGAGTTTCGTGATGGTGTCCGGGTATTCCGGCTTGCCGTCC3240 GCATCCACCAGCACCGACTGCTGGCTGCATTTGCAGTTGATGGAGTTGCCATCTTTGCTG3300 TACCAGTCACGCACCTCTTCGTTGGTGTAGAGGTGGGCATGGGCGCACTGCGTGGGTATG3360 TCGCGTTGTCGGCGACAGAGCTGAGATGTGAACCAGCAGCGTTTTAAGGCCGAACAGGTC3420 ATTCGCCTCTTGGTCTTCATCCCACTTGGCCCGGCGCAGCGCGGTAGTCACTTCAGTGCG3480 TGCTATCCGGTTAGCCCGGCGTTTCTCGATGCCGGTCTGGTCTGTCAGGTTGCGGGCAAT3540 GTCCAGAGGATTGAGCCCGCGCCCAACACCATCAGTAAGACACGCGCCATGTCGCGCTTA3600 ACGTCAGCCGTCAGCCCCTTCATTTCCTCAAATACACGCGCATGCACCAGCGCCATGCGT3660 TTCTGATACTGGTCGCTTGCGAGGATGGAGGCCAGCGACTCACGCCCGGCTGCGTACACC3720 GGGGATTGCTGACTGAGGTTGTAGAACGACTGCCCGGTCCCTTTTTCCGAAGCCAGATCG3780 ATGTACTCGTAAAACCACAGGTCGTAATCGCCACCTTCAAGCAGTACCTGATCAACCAGG3840 TAACTGGCATCGTTCAGGATGATGGAGAGTAGCATTGGGTTTAGCTGGTATTCGTATCTG3900 GCGTTTACTGCGAGGGAGGAAGGTATTTTGTTGAGTGCTGATTTGTACGCCTTGCCAATC3960 TTATTCATCCGCCTGGCGAAGTCTTTCATTGCCCGGCGTTCCAGCGCATCGGCTCCGGTC4020 GGATCCTGATAGTTACGCGGCAGAATCGGTGGCTTCGTCTTCTTCGTCGCCATCCTCTTC4080 TCCTAATGGAAATTCATCGACGTTTTCATAACCGGCAGCAGTGCGGAATTTCTTCACGAC4140 TAAAGGCTGGTTTTTCTCCGCTCCCCTGGAACGTCTGGTTAATCTCTGCCATGGTTTTGG4200 CATTTGCGAGTTTCTCAGTTCCAGTCTGTTCGTTGAGGTCATCCCAGATAACCGTCTTCT4260 CGCTGACTGCATCAATAATTTTCAGGTCGATGAGCTTGTCACTGAAGTCTTCAATTTCGA4320 ATGACAGGTCACCGCGCCGTGACTGGCAGCGCGCGTTGAAATATTTCTGATCCTCGGTGC4380 TTGCCCTTTCACCCGTCTGCATCCCAACCAGAACCTTCACAGGGATATCAACAGATGCAG4440 CGAAGGTTTGCAGGTTGACGTTATAGGTCGCTGACGGATCCGCTACAGCTGTGACCAGTG4500 GTGTGACTGTAGCCCCTTGGGTTGTCATCAGAACATCGTTACCACGGTTCATTTCCCCGG4560 CAACTTCGTTAAACTTATCCTGCAACTCGTCCATGTCACGCCATAAAGTGACGCGAGATT4620 GTTGAAATCGATTTCCTTCTCAAAGTTGACATTAAGCTGCCGCGCGGCGTTCTTTAGGAA4680 TGACTCACCAGAACCACCCTCGACCTTCTCAAGGCTGACGCAGGCGTTATAGCCAGGCTC4740 AAGGAAGCCAATAGCATCATTAGAATAGTCACCAAGGATAAAGACGCGATCGGGATGTAC4800 GAAGCGCTGATTAGTTCCACCGCTTGGAAGGCTCTCAACATATTTCCACTGCTTTGGCTG4860 CCCGTAGCCTGCCGATTTCTGGTCAGTTACCCACTCGCTGACTGTTAATGACCCAGCCCA4920 TGCGATCGTAACCTTTTTTAGTGACTTGCCACGAACAACAGGCTGATCCCATGTTCTGGA4980 ATCATTGATATGCAGCAGGATACCCGCATAACGTCCGACCTGTCGGCGGCGGTCTGCTTC5040 AGCAAAAGCCCGCCAAAGGCGCTTTGTGAAAACCTTTTTGGTGTTCTTCTCCCAGGCAGT5100 TTCATCCTTACTCTCGTCGGCATCATCACCCTCGATGATTTCCGGGTTGGTCTGCCAGCA5160 CTTGCCCACCAGCTTCTCTACTGCGCCGTGGGCTATTCCACCGCGACGATACAGTGCGTA5220 GAGGTTTTCGTAAGTGACCTGCTCAGGGAATCCATACTCGCACCATGCGGAATGGCGCTT5280 ATTGTCCAGCCCCATTGTAGGCGCCAACAGCCCCATACGGGCACGGGCCATCCGCGCATC5340 GTTCAACGCATGGTTGACGGCGAGAGTTAATTTGTCAGTCATGGTTTGTCCGTTGGTGGA5400 TTTAAGGCATAAAAAAAGGCCGCTTTGGCGACCTTGTGGCTATTTAAAAAGCTAAACTCT5460 GTTGAACGAAATAAACATAATCTGCTCAGGCTTAACGCCATAATCACTTGCCAACTTCTG5520 AGTGCACTCAATTAAGACAGTTGATGCAGATTTCGAAGAGCTTGCACCATAAATTTCGAA5580 GTTTTCAAATACTCCGCCGTTGGTGTGGTAAATCTTATATGACATAAACCAATCATTCAT5640 AATATCTACTCCCTTACAGAATTGAGTAGATATTATCGGCAAGTGCATATGTTTCTTTAA5700 ATTATCTCAACCTTTTCGGGATCATCATCCCGGCCATCTGGCCCTTACGTTTAATGTGTC5760 CGTCGAGGCTGTAGCGAATACCGTCCCAGCAGTGTTCGTAACCGTCTGCCAGTTTAGGCA5820 ATACCTCGCCGGTGATGCGGTCCGTTTTGTAGGACCACATGCGGGCCTCTCTCGCCACAT5880 TCTTGCAGCGAGGATGGATAATGATTTCGTCAAAGCCGCGAAGATGCGCGATACCGTCCT5940 CAACACTCCCCTGCCATTTCTCGGCAGCCGAGATGTTGAAGCCCTGGCGCTTGAGATAGC6000 TGATAGTCTCGGGTCGGGCGGAGTCGGCCTTGATGGGCCAGTCACGCGATCCGGGGATTG6060 TGTCGTATAGCTCTGGCATATGGTCGAGCTCTGTCTGCTGACCGTATGCCTCGTATTCGA6120 TGTACAGCCGGTTGTGCAGGATGAACGAGCGCACCAGCGTGTTAGGGTCTTTGGCGAAAC6180 CGAAGTCAGCACCGAAGAAAAGGCGATCGGCCTCTTTCCATAGCTGGTCCGAGAACTCAG6240 CGATCCGGTATTTACCGGCCAGCACCTGCTTATCAGAGTTTTCGAGGTAAGCACCTTCCC6300 AAACCCACGCGTATGTTGCCGGGTCAAGGCGGCGCTGATCGTTCTGTCGCTCACCTTCCA6360 GCACGTCGGGGAACCATGGATTATCCGTGTAGTTCATCTCAACGTGATACAGTCGTCGCC6420 AGCCTCTTTACGGAAACGCTTATCCGTGCGCTGCCGTCGCGCTCCGGGTTCCATGTCACC6480 CAAATCTCTGAACCTTCCTCACGAACGGTCGGGCTCAGCTTCTGCCAGGCTATTTCGCTG6540 ACTGATTCAGCCTCATCAACCCAACAGAGCAAGATGCGCGCTTTCGACTTGATGCTGTCG6600 AGGTTATGCCGCAGACCGCAGAACACGTAGTTAACGCTCTTGTCGATGGTGCGGATGTAC6660 TTCTCGCCGATATCAAAGTTGGAAGCCAGCCAGGGAACAGACAGGATAGCCTGTTTCACC6720 TCCTGCATACTCGACTCTTCCAGTGAGTTCATGAATTCACGCGCACAGAGCACCACGCCG6780 CTTTCACCGTTCATCATCGACTGATACGCCTTTACGGCTGTCATCAGCGCAAAAGTGCGC6840 GTCTTGGCACTACCACGCCCACCATGCGAGCACCGGTAACGCTTATTCTCGGCGATGAAC6900 AGTGGCGCAAGCTT6914 (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5975 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: double (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (vi) ORIGINAL SOURCE: (A) ORGANISM: Klebsiella pneumoniae (B) STRAIN: Clinical Isolate KI- 50 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: AAGCTTATTCCACGCTGGAGGCGTCCGGGATTATCGGCGTCAACGCTATCGCCGGCATCG60 CCGGGACCATCATCGCCGGCATGCTCTCCGACCGCTTTTTCAAACGCAACCGCAGCGTGA120 TGGCCGGATTCATCAGCCTGCTGAACACCGCCGGCTTCGCCCTGATGCTCTGGTCGCCGC180 ACAATTACTACACTGATATTCTGGCGATGATTATCTTCGGGGCCACCATTGGCGCTCTGA240 CCTGCTTCCTTGGCGGGCTGATCGCCGTCGATATCTCTTCGCGCAAGGCCGCCGGGGCCG300 CGCTCGGCACCATCGGCATCGCAGCTACGCCGGCGCCGGCCTGGGCGAGTTTCTCACCGG360 GTTCATTATTGATAAAACGGCTATCCTTGAAAACGGCAAAACGCTGTATGATTTCAGCAC420 GTTGGCGCTGTTCTGGGTGGGTACGGTCTGGGTTCNGCGCTACTCTGTTTTACCACTGCC480 GCCATCGTCGCCCGGCGCCATGCCGTCGAACGGCAGACCTCGTTCTCCTCATAACCGATT540 AACGAATAAGGAAGAAGATATGATGCCTGCAAGACATCAGGGGCTGTTACGCCTGTTTAT600 CGCCTGCGCGCTGCCGCTGCTGGCGCTGCAATCTGCCGCCGCCGCGGACTGGCAGCTGGA660 GAAAGTGGTCGAGCTCAGCCGCCACGGTATTCGTCCGCCGACGGCCGGCAACCGGGAAGC720 CATCGAGGCCGCCACCGGCCGACCGTGGACCGAGTGGACCACCCATGACGGGGAGCTCAC780 CGGCCATGGCTATGCCGCCGTGGTCAACAAAGGGCGTGCGGAAGGCCAGCATTACCGCCA840 GCTCGGCCTGCTGCAGGCCGGATGCCCGACGGCGGAGTCGATATACGTGCGCGCCAGCCC900 GCTGCAGCGGACGCGAGCGACCGCCCAGGCGCTGGTGGATGGCGCCTTCCCCGGCTGCGG960 CGTCGCTATCCATTATGTCAGCGGGGATGCCGATCCCCTGTTTCAGACCGACAAGTTCGC1020 CGCCACGCAAACCGACCCCGCCCGCCAGCTGGCGCGGTGAAAGAGAAGGCCGGGGATCTG1080 GCGCAGGTCGGCAGGCGCTGGCGCCGACCATCCAGCTATTGAAACAGGCGGTTTGTCAGG1140 CCGATAAGCCCTGCCCGATCTTCGATACCCCGTGGCAGGTCGAGCAGAGCAAAAGTGGGA1200 AGACCACCATTAGCGGACTGAGCGTGATGGCCAATATGGTGGAGACGCTGCGTCTCGGCT1260 GGAGTGAAAACCTGCCTCTCAGCCAGCTGGCGTGGGGCAAGATCACCCAGGCCAGGCAGA1320 TCACCGCCCTGCTGCCGCTGTTAACGGAAAACTACGATCTGAGTAACGATGTGTTGTATA1380 CCGCGCAAAAACGCGGGTCGGTGCTGCTCAACGCTATGCTCGACGGCGTCAAACCGGAGC1440 GAATCGAACGTACGCTGGCTGCTGCTGGTGGCCATGACACCAATATCGCCATGGTGCGCA1500 CGCTGATGAACTTTAGCTGGCAGCTGCCGGGCTACAGCCGGGGAAATATCCCGCCGGGCA1560 GCAGCCTGGTGCTGGAGCGCTGGCGCAACGCGAAGAGCGGAGAACGCTATCTGCGGGTCT1620 ATTTCCAGGCCCAGGGCCTCGACGACCTGCGTCGTCTGCAGACGCCGGACGCGCAGACCC1680 CGATGCTGCGTCAGGAGTGGCATCAGCCGGGCTGCCGTCAGACCGATGTCGGTACGCTGT1740 GTCCCTTCCAGGCGGCTATTACCGCCCTCGGTCAGCGTATCGACCGATCATCCGCCCCGG1800 CGGTAGCATGGTCCTGCCGTAGCGGCGCGGTGTTTGTCCGGGCCCGGGAAAACCTTTTTT1860 TCCAGGCCGGCACGACGTCCGTTATCCGTTGTCCGGCGCAAACGCCCCGGCGGCGACCTG1920 CGCCGGGGTGACACCCGCTGTCCAGCACCCAGCCGCTTATCAGCCCAGCAGGCGTGACGT1980 CGAACGCCGGATTGTAAACGGTGGCCCCCGTCGGCGCCCACTGTACCGCGCCGAAGCTGC2040 CCGCCACTCCGGTCACTTCCGCCGCCGCGCGCTGCTCAATGGGGATCGCCGCCCCGTTCG2100 GGCAATGGCGGTCGAGGGTGGTCTGCGGGGCAGCGACGTAAAACGGGATCTGGTGATAAT2160 GGGCCAAAACCGCCAGAGAATAGGTGCCGATTTTATTCGCCACGTCGCCGTTGGCGGCGA2220 TACGGTCGGCGCCGACCCACACCGCATCCACCTGCCCCTGCGCCATCAGGCTGGCGGCCA2280 TTGAATCGGCGATCAGCTGATAGGGCACGCCCAGCTCGCCCAGCTCCCAGGCGGTTAAAC2340 GACCGCCCTGCAGCAGCGGCCGGGTTTCATCAACCCATACGTTGGTCACTTTTCCCTGCC2400 GGTGCGCCAGCGCGATAACGCCGAGGGCGGTCCCTACCCCGGCGGTCGCCAGGCCACCGG2460 TGTTGCAGTGGGTCAGCAGTCGACTGCCGGGCTTCACCAGCGCACTGCCCGCCTCAGCGA2520 TGCGGTCGCACAGCTGTTTATCTTCTTCGACCAGACGCAAGGCTTCCGCTTCCAGCGCCT2580 GCGGGTAATCTCCGGGCCAGCGCTGCTTCATGCGATCAGATTATTCATCAGGTTGACCGC2640 CGTCGGCCGCGCCGCGCGCAGTCTCCAGCGCCTGCTGGAGTGCATCCCGGTTCAGGCCGC2700 GCTGGGCCAGCAGGGCCAGCAGCAGGCTGGCGGACAGGCCAATCAGCGGCGCGCCGCGCA2760 CCCCGCAGGTATGAATATGGTCCACCAGCAGCGCAACGTTATCCGCCGCCAGCCAGCGTT2820 TTTCCTGCGGCAAGGCCTGCTGGTCGAGAATAAAAAGCTGATTTTCACTCACCCGCAGGC2880 TGGTGGTCTGTAATGTCTGCATGTCGTTAAATCCCTGTTGCGTTGTTGTATCACATTGTG2940 TCAGGATGGAATCCAGAAGTATAGACGTCTGAACGGCTTAATCAGAATTCGAGGATCGAG3000 GCAATGTCGCAATACCATACCTTCACCGCCCACGATGCCGTGGCTTACGCGCAGAGTTTC3060 GCCGGCATCGACANCCATCTGAGCTGGTCAGCGCGCAGGAAGTGGGCGATGGCAACTCAA3120 TCTGGTGTTTAAAGTGTTCGATCGCCAGGGCGTCACGGGCGATCGTCAAACAGGCTCTGC3180 CCTACGTGCGCTGCGTCGGCGAATCCTGGCCGCTGACCCTCGACCGCGCCCGTCTCGAAG3240 CGCAGACCCTGGTCGCCCACTATCAGCACAGCCCGCAGCACACGGTAAAAATCCATCACT3300 TTGATCCCGAGCTGGCGGTGATGGTGATGGAAGATCTTTCCGACCACCGCATCTTGCGCG3360 GAGAGCTTATCGCTAACGTCTACTATCCCCAGGCGGCCCGCCAGCTTGGCGACTATCTGG3420 CGCAGGTGCTGTTTCACACCAGCGATTTCTACCTCCATCCCCACGAGAAAAAGGCGCAGG3480 TGGCGCAGTTTATTAACCCGGCGATGTGCGAGATCACCGAGGATCTGTTCTTTAACGACC3540 CGTATCAGATCCACGAGCGCAATAACTACCCGGCGGAGCTGGGAGGCCGATGTCGCCGCC3600 CTGCGCGACGACGCTCAGCTTAAGCTGGCGGTGGCGGCGCTGAAGCACCGTTTCTTTGCC3660 CATGCGGAAGCGCTGCTGCACGGCGATATCCACAGCGGGTCGATCTTCGTTGCCGAAGGC3720 AGCCTGAAGGCCATCGACGCCGAGTTCGGCTACTTCGGCCCCATTGGCTTCGATATCGGC3780 ACCGCCATCGGCAACCTGCTGCTTAACTACTGCGGCCTGCCGGGCCAGCTCGGCATTCGC3840 GATGCCGCCGCCGCGCGCGAGCAGCGGCTGAACGACATCCACCAGCTGTGGACCACCTTT3900 GCCGAGCGCTTCCAGGCGCTGGCGGCGGAGAAAACCCGCGACGCGGCGCTGGCTTACCCC3960 GGCTATGCCTCCGCCTTTCTGAAAAAGGTGTGGGCGGACGCGGTCGGCTTCTGCGGCAGC4020 GAACTGATCCGCCGCAGCGTCGGACTGTCGCACGTCGCGGATATCGACACTATCCAGGAC4080 GACGCCATGCGTCATGAGTGCCTGCGCCACGCCATTACCCTGGGCAGAGCGCTGATCGTG4140 CTGGCCGAGCGTATCGACAGCGTCGACGAGCTGCTGGCGNGGGTACGCCAGTACAGCTGA4200 GTGCGCCTGTTTCCCTCACCCCAACCCTCTCCCACAGGGAGAGGGAGCACCCCCTAAAAA4260 AGTGCCATTTTCTGGGATTGCCCGGCGNGNTGCGCTTGCCGGGCCTACAGATAGCCGCAT4320 AACGGTTTGATCTTGCACTCTTTCGTAGGCCGGGTAAGGCGAAAGCCGCCACCCGGCAGA4380 CATGCGAGTACAATTTTGCATTTACCTTACCCTCACCCCAGATACTCAATCACCGATAGC4440 CCGCCGTTGTAATCGGTGCTGTAGATAATGCCTTGCGCATCGACAAACACGTCACAGGAC4500 TGGATCACCCGCGGGCGGCCGGGACGGGTATCCATCATTCTCTCAGCGCAGCCGGCACCA4560 GCGCCCCGGTCTCCAGCGGGCGATACGGGTTGGAAATGTCGTAAGCCCGCACGCCGGCAT4620 TCTGATACGTGGCAAAAATCAGCGTTGAGCTGACAAAGCTCCCCGGCCGGTTCTCATGCA4680 GGTTGTGCGGACCGAAATGCGCCCCTTTCGCCACGTAATCCGCTTCATCCGGCGGCGGGA4740 AGGTGGCGATGCTCACCGGGTTGGTTGGCTCGCGGATATCAAACAGCCAGATCAGCTTCT4800 CGCCGTCCTCCTGGTTATCGAGCACCGCTTCATCCAGCACCACCAGCAGATCGCGATCCG4860 GCAGCGGCAGCGCGGTATGCGTTCCGCCGCCGAACGGCGGGCTCCAGTTGCGATGGCTAA4920 TCAGCCTCGGCTGGGTACGGTCTTTGACATCCAGCAGCGTCAGGCCGCCGTCGCGCCAGC4980 TGCGTAGGCGTATCCCCGGCAATAATGGCGTGATGCAGCGCATAGCGTTTGCCCTGCGGC5040 CAGTCCGGTGTTTCACCGCCCGCCTGGTGCATCCCCGGCAGCCACCAGCGCCCGGCTACT5100 TCGGGCTTACGCGGATCGGCCAGATCGATGGTCAGGAAGATGTAGTCGGTAAAACCGTCG5160 ATCAGCGCAGACACATACGCCCAGCGCCCGCCGACGTACCAGATGCGGTGAATACCGATG5220 CCGTTAAGCGACAGGAAACTGATTTCCCGCGCTGCGCGGGAGTGGAAATATCAAAGATGC5280 GCAGCCCGGCGCTCCAGCCCCTGTCCTGCACATCGCTGACCGTGTCACCCACCGAGCGGG5340 TGTAGTACACCTTCTCATCAGCAAAACGGGCGTCAGCAAACAGATCCCGGGCGTTGATCA5400 CCAGCAGCAGATCGTCATGCGCCTGGAGTGCACGTTCCAGGTGCCCGGCGGCGCGGCAAT5460 ATAGTTGACGGTGGTGGGCCGGGTCGGATCGCGAACATCGACCACGGAAAAACCCTGCGA5520 CACCATATGGCCGATATAGGCGAATCCGCGGTGCACCATCAGCTGCACGCCGTCCGGACG5580 ACCGCCCTGATCGCTATGGCCAATCAGCCGCATATTGCGGCTGTATTCGGGGGAAGGTAA5640 TGCTGACATAGGGGATCCCTCTCGCCCGGTGGCATGGTTTTCCCCCCTCTCCTGCGGAGA5700 GGGCCGGGGCGAGGGCACCAGGCCGCCGCCCACCGCCACCCGGCTTGATTTTATTTGTTC5760 TTCGCTTCCAGCGTCGCGAACCACGGCGCGATAAAGTCTTCGGTCTGGCCCCAGCCAGGG5820 ATAATTTTCCCCAGCGACGCCACGTTTACCGCTCCCGGCTGGGCCGCCAGCAGCGCCTGG5880 GGAATCGCTGCCGCCTTGAAGTCGTAGGTGGCTGGCGTCGGCTCGCCGGCGATCTTGTTG5940 GCGATCAGCCGCACGTTGGTCGCGCCGATAAGCTT5975 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: other nucleic acid (A) DESCRIPTION: /desc = "primer" (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: CGACGTTGTAAAACGACGGCCAGT24 (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: other nucleic acid (A) DESCRIPTION: /desc = "primer" (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: CAGGAAACAGCTATGAC17 __________________________________________________________________________

## Claims

1. A probe composition for detecting Escherichia coli, Klebsiella pneumoniae or Enterobacter cloacae wherein the probe composition consists essentially of

2. A method for detecting the presence of Escherichia coli, Klebsiella pneunmniae or Enterobacter cloacae in a sample comprising the steps of contacting nucleic acid from said sample with the probe composition of claim 1 and detecting hybridization of the nucleic acid from said sample with DNA in said probe composition as an indication of the presence of Escherichia coli, Klebsiella pneumoniae or Enterobacter cloacae.