Exhibit 10.25



AMENDMENT 3
TO TERM LOAN AGREEMENT



THIS AMENDMENT 3, dated as of December 29, 2015
(this “Amendment”) is made among TearLab Corporation, a Delaware corporation (“Borrower”),
the subsidiary guarantors listed on the signature pages hereof under the heading “SUBSIDIARY GUARANTORS” (each a “Subsidiary
Guarantor” and, collectively, the “Subsidiary Guarantors”) and the lenders listed on the
signature pages hereof under the heading “LENDERS” (each a “Lender” and, collectively, the
“Lenders”), with respect to the Loan Agreement referred to below.



RECITALS



WHEREAS, the Borrower and the Lenders are parties
to a Term Loan Agreement, dated as of March 4, 2015, as amended by the Omnibus Amendment Agreement, dated as of April 2, 2015,
and by Amendment 2, dated as of August 6, 2015 (the “Loan Agreement”), with the Subsidiary Guarantors
from time to time party thereto.



WHEREAS, the parties hereto desire to amend the
Loan Agreement on the terms and subject to the conditions set forth herein.



NOW, THEREFORE, in consideration of the mutual
agreements, provisions and covenants contained herein, the parties agree as follows:



SECTION 1.	Definitions; Interpretation.



(a)	Terms Defined in Loan Agreement.
All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise defined herein shall have the
meanings assigned to them in the Loan Agreement.



(b)	Interpretation. The rules of interpretation
set forth in Section 1.03 of the Loan Agreement shall be applicable to this Amendment and are incorporated herein by this
reference.



SECTION 2.	Amendment. Subject to Section
3, the Loan Agreement is hereby amended as follows:



(a)	Section 10.02(b)of the Loan Agreement
is amended and restated in its entirety as follows:



“(b) during the twelve month period beginning
on January 1, 2016, of at least $30,000,000;”



SECTION 3.	Conditions of Effectiveness.
The effectiveness of Section 2 shall be subject to the following conditions precedent:



(a)	The Borrower shall have paid or reimbursed
Lenders for Lenders’ reasonable out of pocket costs and expenses incurred in connection with this Amendment, including Lenders’
reasonable and documented out of pocket legal fees and costs, pursuant to Section 12.03(a)(i)(z)of the Loan Agreement.













(b)	The representations and warranties in Section
4shall be true in all material respects on the date hereof and on the first date on which the condition set forth in Section
3(a) shall have been satisfied.



SECTION 4.	Representations and Warranties;
Reaffirmation.



(a)	The Borrower hereby represents and warrants
to each Lender as follows:



(i)	The Borrower has full power, authority
and legal right to make and perform this Amendment. This Amendment is within the Borrower’s corporate powers and has been
duly authorized by all necessary corporate and, if required, by all necessary shareholder action. This Amendment has been duly
executed and delivered by the Borrower and constitutes a legal, valid and binding obligation of the Borrower, enforceable against
the Borrower in accordance with its terms, except as such enforceability may be limited by (a) bankruptcy, insolvency, reorganization,
moratorium or similar laws of general applicability affecting the enforcement of creditors’ rights and (b) the application
of general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law).
This Amendment (x) does not require any consent or approval of, registration or filing with, or any other action by, any Governmental
Authority or any third party, except for such as have been obtained or made and are in full force and effect, (y) will not violate
any applicable law or regulation or the charter, bylaws or other organizational documents of the Borrower and its Subsidiaries
or any order of any Governmental Authority, other than any such violations that, individually or in the aggregate, could not reasonably
be expected to have a Material Adverse Effect, (z) will not violate or result in an event of default under any material indenture,
agreement or other instrument binding upon the Borrower and its Subsidiaries or assets, or give rise to a right thereunder to require
any payment to be made by any such Person.



(ii)	No Default has occurred or is continuing
or will result after giving effect to this Amendment.



(iii)	The representations and warranties made
by or with respect to the Borrower in Section 7 of the Loan Agreement are true in all material respects (taking into account
any changes made to schedules updated in accordance with Section 7.21 of the Loan Agreement or attached hereto), except
that such representations and warranties that refer to a specific earlier date were true in all material respects on such earlier
date.



(iv)	There has been no Material Adverse Effect
since the date of the Loan Agreement.



(b)	The Borrower hereby ratifies, confirms,
reaffirms, and acknowledges its obligations under the Loan Documents to which it is a party and agrees that the Loan Documents
remain in full force and effect, undiminished by this Amendment, except as expressly provided herein. By executing this Amendment,
the Borrower acknowledges that it has read, consulted with its attorneys regarding, and understands, this Amendment.





2







SECTION 5.	Governing
Law; Submission to Jurisdiction; Waiver of Jury Trial.



(a)	Governing Law. This Amendment and
the rights and obligations of the parties hereunder shall be governed by, and construed in accordance with, the law of the State
of New York, without regard to principles of conflicts of laws that would result in the application of the laws of any other jurisdiction;
provided that Section 5-1401 of the New York General Obligations Law shall apply.



(b)	Submission to Jurisdiction. The
Borrower agrees that any suit, action or proceeding with respect to this Amendment or any other Loan Document to which it is a
party or any judgment entered by any court in respect thereof may be brought initially in the federal or state courts in Houston,
Texas or in the courts of its own corporate domicile and irrevocably submits to the non-exclusive jurisdiction of each such court
for the purpose of any such suit, action, proceeding or judgment. This Section 5 is for the benefit of the Lenders only
and, as a result, no Lender shall be prevented from taking proceedings in any other courts with jurisdiction. To the extent allowed
by applicable Laws, the Lenders may take concurrent proceedings in any number of jurisdictions.



(c)	Waiver of Jury Trial. The
Borrower and each Lender hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial
by jury in any suit, action or proceeding arising out of or relating to this Amendment, the other Loan Documents or the transactions
contemplated hereby or thereby.



SECTION 6.	Miscellaneous.



(a)	No Waiver. Nothing contained herein
shall be deemed to constitute a waiver of compliance with any term or condition contained in the Loan Agreement or any of the other
Loan Documents or constitute a course of conduct or dealing among the parties. Except as expressly stated herein, the Lenders reserve
all rights, privileges and remedies under the Loan Documents. Except as amended hereby, the Loan Agreement and other Loan Documents
remain unmodified and in full force and effect. All references in the Loan Documents to the Loan Agreement shall be deemed to be
references to the Loan Agreement as amended hereby.



(b)	Severability. In case any provision
of or obligation under this Amendment shall be invalid, illegal or unenforceable in any jurisdiction, the validity, legality and
enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction, shall
not in any way be affected or impaired thereby.



(c)	Headings. Headings and captions
used in this Amendment (including the Exhibits, Schedules and Annexes hereto, if any) are included for convenience of reference
only and shall not be given any substantive effect.



(d)	Integration. This Amendment constitutes
a Loan Document and, together with the other Loan Documents, incorporates all negotiations of the parties hereto with respect to
the subject matter hereof and is the final expression and agreement of the parties hereto with respect to the subject matter hereof.



(e)	Counterparts. This Amendment may
be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument and any of
the parties hereto may execute this Amendment by signing any such counterpart.



(f)	Controlling Provisions. In the event
of any inconsistencies between the provisions of this Amendment and the provisions of any other Loan Document, the provisions of
this Amendment shall govern and prevail. Except as expressly modified by this Amendment, the Loan Documents shall not be modified
and shall remain in full force and effect.



[Remainder of page intentionally
left blank]



3







IN WITNESS WHEREOF, the parties hereto have duly
executed this Amendment, as of the date first above written.



| | BORROWER:             
| | ----------------------
| |                       
| | TEARLAB CORPORATION   
| |                       
| | By:                   
| | Name:                 
| | Title:                
| |                       
| | SUBSIDIARY GUARANTORS:
| |                       
| | TEARLAB RESEARCH, INC.
| |                       
| | By:                   
| | Name:                 
| | Title:                
| |                       
| | OCUHUB HOLDINGS, INC. 
| |                       
| | By:                   
| | Name:                 
| | Title:                
| |                       
| | OCUHUB LLC            
| |                       
| | By:                   
| | Name:                 
| | Title:                
| |                       
| | OCCULOGIX CANADA CORP.
| |                       
| | By:                   
| | Name:                 
| | Title:                











|LENDERS:                                                     |                                                             | 
|------------------------------------------------------------ | ----------------------------------------------------------- | 
|                                                             |                                                             | 
|CAPITAL ROYALTY PARTNERS II L.P.                             |                                                            
|                                                             |                                                             | 
|By: CAPITAL ROYALTY PARTNERS II GP L.P., its General Partner
|                                                             |                                                             | 
|                                                             | By: CAPITAL ROYALTY PARTNERS II GP LLC, its General Partner



| | By:    | /s/ Nathan Hukill    | 
| | ------ | -------------------- | 
| | Name:  | Nathan Hukill        | 
| | Title: | Authorized Signatory | 



|CAPITAL ROYALTY PARTNERS II – PARALLEL FUND “A” L.P.                             |                                                                                   
|-------------------------------------------------------------------------------- | ----------------------------------------------------------------------------------
|                                                                                 |                                                                                   
|By: CAPITAL ROYALTY PARTNERS II – PARALLEL FUND “A” GP L.P., its General Partner |                                                                                   
|                                                                                 |                                                                                   
|                                                                                 | By CAPITAL ROYALTY PARTNERS
    II – PARALLEL FUND “A” GP LLC, its General Partner



| | By:    | /s/ Nathan Hukill    | 
| | ------ | -------------------- | 
| | Name:  | Nathan Hukill        | 
| | Title: | Authorized Signatory | 



|PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.                             | 
|------------------------------------------------------------------------------ | 
|                                                                               | 
|By: PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II GP L.P., its General Partner | 
|                                                                               | 
|By: PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II GP LLC, its General Partner  | 



| | By:    | /s/ Nathan Hukill    | 
| | ------ | -------------------- | 
| | Name:  | Nathan Hukill        | 
| | Title: | Authorized Signatory | 













|CAPITAL ROYALTY PARTNERS II – PARALLEL FUND “B” (CAYMAN) L.P.         | 
|--------------------------------------------------------------------- | 
|                                                                     
|By: CAPITAL ROYALTY PARTNERS II (CAYMAN) GP L.P., its General Partner | 
|                                                                      | 
|By: CAPITAL ROYALTY PARTNERS II (CAYMAN) GP LLC, its General Partner  | 



| | By:      | /s/ Nathan Hukill    | 
| | -------- | -------------------- | 
| | Name:    | Nathan Hukill        | 
| | Title:   | Authorized Signatory | 
| |          |                      | 
| | WITNESS: | /s/ Zain Shekhani    | 
| | Name:    | Zain Shekhani        |