Saflufenacil Dietary Exposure and Risk Assessment

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### UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY**

**MEMORANDUM D**  **ATE :**  04 - AUG - 2011 **SUBJECT: Saflufenacil**  **.** Acute and

Exposure and Risk Assessment for Coffee, Banana, and Mango **PC Code:** 118203 **Decision No .:**  442242 **Petition No.:** 0E7806 **Risk Assessment Type:** Dietary **T XR No.:**  NA **MRID No.:** NA **FROM:** George F. Kramer, Ph.D.,

Risk Assessment Branch **THROUGH:** David E. Hrdy, Senior Biologist

Dennis McNeill y, Chemist Dietary Exposure Science Advisory Council (DESAC) HED (7509P) and Dana M. Vogel, Branch Chief RAB1/HED (7509P) **TO:** George F. Kramer, Ph.D.,

RAB1/HED (7509P) and Kathry n Montague/ Registration Division (RD) (7505P) **Executive Summary** Acute and chronic dietary - exposure and risk assessments were conducted Exposure Evaluation Model soft ware with the Food Commodity Intake Database (DEEM FCID TM 

### , Version 2.03) which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994 Dietary Exposure and Risk Assessment DP Number:

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### Page 1 of 18 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 CHEMICAL SAFETY AND**  **POLLUTION PREVENTION**



### Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for Tolerances for Residues in/on Coffee, Banana, and Mango . **DP Barcode:** D 3 9 0 923 **Registration No. :**  7969 - 278 **Regulatory Action:** Tolerances With No U.S. Registration Dietary **Case No.:** NA

**CAS No.:** 372137 - 35 - 4 **40 CFR:** §180.649 George F. Kramer, Ph.D., Senior Chemist Risk Assessment Branch 1 (RAB1) /Health Effects Division (HED; 7509P) Hrdy, Senior Biologist Dennis McNeill y, Chemist Dietary Exposure Science Advisory Council (DESAC) Dana M. Vogel, Branch Chief RAB1/HED (7509P) George F. Kramer, Ph.D., Risk Assessor RAB1/HED (7509P) Kathry n Montague/ Susan Stanton , PM Team 23 Registration Division (RD) (7505P)

exposure and risk assessments were conducted using the ware with the Food Commodity Intake Database (DEEM which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994 DP Number: 390923

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### UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY OFFICE OF**  **CHEMICAL SAFETY AND POLLUTION PREVENTION** 



### Chronic Aggregate Dietary (Food and Drinking Water) Tolerances for Residues in/on Imported

Tolerances With No U.S.

/Health Effects Division (HED; 7509P)

using the Dietary ware with the Food Commodity Intake Database (DEEM which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994 - 1996 andSaflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 2 of 18 1998. These analy ses were performed to support a tolerance petition for residues in/on imported coffee, banana, and mango . Acute Dietary

(Food and Drinking Water) Exposure Results and Characterization The unrefined acute analy sis assumed 100% crop treated (CT), DEEM TM 

### 7.81 defa ult concentration factors, and tolerance - level residues for all commodities [ except for cottonseed; sunflower subgroup 20 B ; soy bean, seed; vegetable, legume, subgroup 6C, pea and bean (except soy bean); and rapeseed subgroup 20A

– see Section II for more de tail s] . The drinking water estimate from the existing U.S. uses was incorporated directl y into the dietary assessment using the concentration for ground water generated b y the Tier II Pesticide Root Zone Model Ground Water (PRZM GW ) . The acute dietary risk estimates (food + water) at the 95 th 

### percentile are <1% of the acute population - adjusted dose (aPAD) for the general U.S. population and <1 % of the aPAD for the most highl y exposed population subgroup ( all infants (<1 year old) ) and are thus below HED’s level of concern (<100% aPAD). Chronic Dietary

(Food and Drinking Water) Exposure Results and Characterization The unrefined chronic analy sis assumed 100% CT , DEEM TM 

### 7.81 default concentration factors , and tolerance - level residues for all commodities [ except for cottonseed; sunflower subgroup 20 B ; soy bean, seed; vegetable, legume, subgroup 6C, pea and bean (except soy bean); and rapeseed subgroup 20A

– see Section II for more detail s]. The drinking wate r estimate from the existing U.S. uses was incorporated directl y into th e dietary assessment using the concentration for ground water generated by PRZM GW . The chronic dietary risk estimates (food + water) 9.2 % of the chronic population - adjusted dose (cPAD) for the general U.S. population and 3 1 % of the cPAD for the most highl y exposed population subgroup ( all infants (<1 year old) ) and are thus below HED’s level of concern (<100% cPAD). Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization Saflufenacil is classified as “not likely carcinogenic to humans.” Therefore, cancer risk is not a concern for this chemical. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to point of departure (POD, NOAEL, LOAE L, i.e. ) divided by the required uncertainty or safet y factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA PEST/2000/July

/Day - 12/6061.pdf

; or see SOP 99.6 (20 - AUG - 1999).Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 3 of 18 The most recent dietary

exposure risk assessment for saflufenacil was conducted by G. Kramer (Memo, 24 - MAR - 2011 , D381976 ). **II. Residue Information**  Saflufenacil Proposed and Registered Uses: Saflufenacil is currentl y registered for use on legume vegetabl es ( crop group 06), the foliage of legume vegetables ( crop group 07), cereal grains ( crop group 15), forage, fodder , and straw of cereal grains ( crop group 16), cottonseed ( subgroup 20C ) , r apeseed ( subgroup 20A ), and s unflower ( subgroup 20B ) . BASF has submitted a tolerance petition for residues in/on imported coffee, banana, and mango . Residues of Concern: The nature of the residue in plants, rotational crops, and livestock is adequatel y understood based on acceptable metabolism studies con ducted on corn (preplant application), so ybean (preplant and pre harvest application), tomato (preplant application), rotational crops, lactating goats, and laying hens. The HED Residues of Concern Knowledgebase Subcommittee (ROCKS) determined that residue s of concern for the tolerance expression and risk assessment in plants consist of saflufenacil, M800H11, and M800H35 ; and that saflufenacil is the only residue of concern in livestock (Memo, B. Daiss, 1/6/09; D 359645 ). An additional major metabolite ( M800H02 ) that is not included in the tolerance expression was observed in so ybean seed following pre harvest (harvest aid) application . As the structure of M800H02 is closely

related to the parent compound and it is the precursor of the regulated metabolit e M800H11, RAB1 concludes that M800H02 is a residue of concern for risk assessment purposes in crops following post - emergence treatment. **Table 1. Summary of Metabolites and Degradates to be**  **I ncluded in the Risk Assessment**  **. Matrix**  **Residues included in Risk**  **Assessment Residues included in**  **Tolerance Expression** Plants Primary Crops (preplant

application) Saflufenacil + M800H11, M800H35 Saflufenacil + M800H11, M800H35 Primary Crops (pre harvest application) Saflufenacil + M800H11, M800H02 , M800H35 Rotational Crops Saflufenacil + M800H11, M800H35 Livestock Ruminants Saflufenacil Saflufenacil

Poultry Drinking Water Saflufenacil + M800H 0 1, M800H 0 2, M800H 07, M800H 0 8, M800H 15, M800H 22, P roduct 8 Not Applicable 

### Established Tolerances: Permanent tolerances for “ saflufenacil, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined b y measuring only the sum of saflufenacil, 2 - chloro - 5 - [3,6 - dihydr o - 3 - methyl - 2,6 - dioxo - 4 - (trifluoromethyl) - 1(2H ) - py rimidinyl] - 4 - fluoro -N

- [[methyl(1 - methylethyl)amino]sulfonyl]benzamide, and its metabolites N - [2 - chloro - 5 - (2,6 - dioxo - 4 - (trifluorometh yl ) - 3,6 - dihydro - 1(2H ) - py rimidinyl) - 4 - fluorobenzo yl ] -N ' - isopropylsulfamide and N - [4 - chloro - 2 - fluoro - 5 - ({[(isopropylamino)sulfonyl]amino}carbon yl )phenyl]urea, calculated as the stoichiometric equivalent of saflufenacil ” are currentl y established under 40 CFRSaflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 4 of 18 §180.649 (a)(1) for residues on citrus fruit ( Crop Gr oup 10), pome fruit ( Crop Group 11), stone fruit ( Crop Group 12), grape, tree nuts ( Crop Group 1 4 ), legume vegetables ( crop group 06), the foliage of legume vegetables ( crop group 07), cereal grains ( crop group 15), forage, fodder , and straw of cereal grai ns ( crop group 16), cottonseed ( subgroup 20C ), r apeseed ( subgroup 20A ), and s unflower ( subgroup 20B ) . Additionally , permanent tolerances for “ saflufenacil, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only

saflufenacil, 2 - chloro - 5 - [3,6 - dihydro - 3 - methyl - 2,6 - dioxo - 4 - (trifluoromethyl) - 1(2H ) - py rimidinyl] - 4 - fluoro -N

- [[methyl(1 - methylethyl)amino]sulfonyl]benzamide ” are currently establ ished under 40 CFR §180.649 (a)(2) for residues on livestock commodities . Recommended Tolerances: Based on the residue chemistry data submitted with the current petition, HED recommended for establishment of the following tolerances (G. Kramer , 04 - AUG 201 1 ; D 390922 ): **Table 2. Tolerance Summary for Saflufenacil.** Commodity Recommended Tolerance (ppm) Coffee, green bean 0.03 Banana 0.03 Mango 0.03 

### Residue Data used for Acute and Chronic Assessments: The acute and chronic assessments were based on the assumption of tolerance - level residues for all commodities, except for cottonseed; sunflower subgroup 20 B ; soy bean, seed; vegetable, legume, subgroup 6C, pea and bean (except soy bean); and rapeseed subgro up 20A . For the se crops , residues were also based on the recommended tolerances; however, a correction factor was applied to the tolerance level to account for the M800H02 metabolite included in the risk assessment as a result of preharvest uses . The add itional metabolite, M800H02 , w as observed in the metabolism studies of preharvest - treated soy bean seed, comprising 2 6 . 3 % of the total radioactive residues ( G. Kramer, 3/24 / 11 ; DP# 381129 ). Since the toxicity of the M800H02 is expected to be comparable to the parent compound, it was included in the risk assessment for preharvest uses , but not in the tolerance expression. To account for this additional toxicity exposure, the recommended tolerance level was multiplied by a correction factor of 1. 7 x, where 1. 7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression). 1.7 = (Saflufenacil + M800H11 + M800H02 + M800H35)/(Saflufenacil + M800H11 + M800H35) = (2 6 . 1 % + 10. 9 % + 2 6 . 3 % + 0% )/( 2 6 . 1 % + 10. 9 % + 0% ) 

### Therefore, in the acute and chronic assessments , a residue of 0.34 ppm was used for cottonseed; a residue of 1.7 ppm was used for sunflower subgroup 20 B ; a residue of 0.17 ppm was used for soy bean, seed; a residue of 0.51 ppm was used for vegetable, legume, subgroup 6C, pea and bean (except soy

bean); and a residue of 0.76 ppm was used for rapeseed subgroup 20A (see Table 3 ).Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 5 of 18 **Table 3**  **. Corrected Residues Used in the Chronic Assessment. Crop Group and/or Comm**  **odity Tolerance (ppm)**  2 **Corrected Residue Used in Dietary**  **Assessment s**  **1** Cottonseed Subgroup 20C 0.20 0. 34 Sunflower Subgroup 20B 1.0 1. 7 Soy bean, seed 0.10 0.1 7 Vegetable, Legume, Subgroup 6C, pea and bean (except soybean) 0.30 0. 51 Rapeseed Subgroup 20A 0.45 0. 76 1 Tolerance level residues were corrected to account for the addition of the M800H02 metabolite which was observed in the metabolism studies of preharvest - treated soybean seed . The recommended tolerance level was multiplied by a correction factor of 1. 7 x, where 1. 7 = (Metabolite s in Risk Assessment)/(Metabolite s in Tolerance Expression). 2 These are HED - recommended tolerances based on Petition s 0F7744 and 0F7766 . 

### %CT Information : The chronic assessment was based on the assumption of 100% CT for all commodities. Processing Factors: DEEM TM 

### 7.81 default processing factors were used for all processed commodities (where provided). **III. Drinking Water Data**  The Estimated Drinking Water Concentrations (EDWC s ) used in the dietary exposure risk assessment were provided by the Environmental Fate and Effects Division (EFED) in a memorandum dated 0 4 / 1 5 /0 9 (Memo, G . Orrick ; DP# 349860 ) . Water residues were incorporated directl y into the DEEM - FCID TM 

### into the food categories “water, direct, all sources” and “water, indirect, all sources.” Screening EDWC s ( Table 3 ) of saflufenacil were generated with FQPA Index Reservoir Screening Tool (FIRST) for surface water and with PRZM GW for ground water. Modeled application rates represent the maximum use patterns of five proposed end - use labels with selected uses on row crops, orchard trees, vineyards, tree plantations, and non - agricultural areas . Remaining model input parameters were chosen according to current guidance (USEPA, 2002). EDWCs reflect exposure to saflufenacil and all degradates of concern in drinking water ( Table 1 ). **Table 3. Tiered EDWCs**  **for Proposed Saflufenacil Uses. Source (Tier: Model)**  **1 -**  **in -**  **10 -** **year Peak Exposure (**  **ppb )**  **1 -**  **in -**  **10 -** **year Annual Mean Exposure (**  **ppb )**  Surface water (Tier I: FIRST) 37.3 23.8 Ground water (Tier II: PRZM GW) 180 (used in acute analysis) 173 (used in chronic analysis) 

### IV. **DEEM -**  **FCID TM**  

### Program and Consumption Information Saflufenacil acute and chronic dietary exposure assessments were conducted using DEEM FCID TM 

### , Version 2.03, which incorporates consumption data from USDA’s CSFII, 1994 - 1996 and 1998. The 1994 - 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” ( i.e. , apple pie) are linked to EPA - defined food commodities ( i.e. apples, peeled fruit - cooked; fresh or N/S; baked;Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 6 of 18 or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on anal ys is of the 1994 - 96, 98 CSFII consumption data, which took into account dietary patterns and sur

vey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 ye ar old), children 1 - 2 ye ars old, children 3 - 5 ye ars old, children 6 - 12 ye ars old, youth 13 - 19 ye ars old, females 13 - 49 ye ars old, adults 20 - 49 ye ars old, and adults 50+ years old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food form ( i.e. , orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments, individua l one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic expos ure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eati ng relevant commodities/food forms) and a per - capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of anal ysis. Howeve r, for Tiers 1 and 2, an y significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment. **V. Toxicological Information**  **Table 4**  **. Summary of Toxicological Doses and Endpoints for S**  **aflufenaci l**  **for Use in Dietary Hum an**  **- Health Risk**  **Assessments. Exposure/**  **Scenario Point of** 

**Departure Uncertainty/** 

**FQPA SF**  **s RfD, PAD,** 

**LOC for Risk Assessment**  **Study and Toxicological Effects** Ac ute Dietary (General Population, including Infants and Children) NOAEL = 500

mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1X **Acute RfD** =

5.0 mg/kg aPAD = 5.0 mg/kg Ac ute Neurotoxicity Study .

NOAEL = 500 (M) and 2000 (F) mg/kg/day . LOAEL was 2000 mg/kg/day (males) based on the decreased motor activity representing mild and transient systemic toxicity. LOAEL was not established for females. Chronic Dietary (All Populations) NOAEL = 4.6

mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1X **Chronic RfD**

= 0.046 mg/kg/day **cPAD** = 0.046 mg/kg/day Chronic/Carcinogenicity (mouse) .

NOAEL = 4.6 mg/kg bw/d (males) and 18.9 mg/kg bw/d (females). LOAELs = 13.8 mg/kg bw/d (males) and 38.1 mg/kg bw/day (females) based on decreased red blood cells, hemoglobin, and hematocrit and porphyria observed in the satellite group.Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 7 of 18 **Table 4**  **. Summary of Toxicological Doses and Endpoints for S**  **aflufenaci l**  **for Use in Dietary Hum an**  **- Health Risk**  **Assessments.** Cancer (oral, dermal, inhalation) Classification: Not carcinogenic based on the lack of tumors in the mouse and rat carcinogenicity

studies and lack of mutagenicity. NOAEL = no - observed adverse - effect level. LOAEL = lowest - observed adverse - effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population - adjusted dose (a = acute, c = chronic). RfD = reference dose. LOC = level of concern. 

### VI. **Results/Discussion** For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID TM 

### analy ses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 3 are for the general U.S. population, all infants (<1 year old), children 1 - 2 ye ars old, childr en 3 - 5 ye ars old, children 6 - 12 ye ars old, youth 13 - 19 ye ars old, females 13 - 49 ye ars old, adults 20 - 49 years old, and adults 50+ ye ars old. Results of Acute and Chronic Dietary Exposure Analy ses The acute dietary risk for food and drinking water utilized (<1 % of the aPAD for the U.S. population. The acute dietary risk for the highest exposed population subgroup, a ll i nfants (<1 ye ar old) , i s <1 % of the aPAD at the 95 th 

### percentile . The chronic dietary risk for food and drinking water utili zed 9.2 % of the cPAD for the U.S. population. T he chronic dietary risk for the highest exposed population subgroup, a ll i nfants (<1 ye ar old) , i s 3 1 % of the cPAD. The results of the acute and chronic dietary exposure anal ys es are reported in Table 5. **Table 5**  **. Summary of Dietary (Food and Drinking Water) Exposure Risk for Saflufenacil .**  Population Subgroup Ac ute Dietary (95 th Percentile) Chronic Dietary Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD General U.S. Population 0.010415 <1 0.0042 32 9. 2 All Infants (<1 year old) **0.038388** <1 **0.014043 3**  **1** Children 1 - 2 years old 0.0172 62 <1 0.0072 90 1 6 Children 3 - 5 years old 0.0154 38 <1 0.0065 35 1 4 Children 6 - 12 years old 0.01047 1 <1 0.0043 83 1 0 Youth 13 - 19 years old 0.0084 51 <1 0.0031 64 6.9 Adults 20 - 49 years old 0.0092 6 6 <1 0.0038 2 1 8. 3 Adults 50+ years old 0.0083 88 <1 0.00395 9 8.6 Females 13 - 49 years old 0.0093 36 <1 0.003 802 8. 3 *The values for the highest exposed population for each type of risk assessment are bolded.Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 8 of 18 **VII. Characterization of Inputs/Outputs**  These acute and chronic dietary exposure and risk estimates are conservative since they assumed 100% CT, DEEM TM 

### 7.81 default concentration factors , and tolerance - level or higher residues and were based on screening level estimates of drinking water concentrations generated b y PRZM GW . They

could be further refined through the use of anticipated residues, empirical processing factors and % CT data, as well as refined drinking water estimates. **VIII. Conclusions**  The acute and chronic dietary exposure and risk analy s e s using DEEM - FCID TM 

### indicates that dietary risk s to saflufenacil from food and drinking water are well below HED’s levels of concern for this pesticide. Estimated acute dietary risk s are <1 % of the aPA D at the 95 th 

### percentile for the general U.S. population and all population subgroups and estimated chronic dietary risks are ≤ 3 1 % of the cPAD for the general U.S. population and all population subgroups . **IX. List of Attachments** 

· Acute Food plus Water Residue Input File.

· Acute Results File.

· Chronic Food plus Water Residue Input File.

· Chronic Results File.

cc: G. Kramer (RAB1) RDI : DESAC ( 7 / 18 / 1 1 ) G.F. Kramer: S10 95 7 :PY - S:(703)305 - 5079:7509P:RAB1Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 9 of 18 Acute Food plus Water Residue Input File Filename: C: \ Documents and Settings \ gkramer \ My Documents \ Gk \ ##Saflufenacil new \ 0E7806 \ Saflufenacil_Acute.R98 Chemical: Saflufenacil RfD(Chronic): .046 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 5 mg/kg bw/day NOEL(Ac ute): 0 mg/kg bw/day Date created/last modified: 07 - 14 - 2011/14:09:07/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 06003470 6 Soybe an, seed 0.170000 1.000 1.000 06003480 6 Soybean, flour 0.170000 1.000 1.000 06003481 6 Soybean, flour - babyfood 0.170000 1.000 1.000 06003490 6 Soybean, soy milk 0 .170000 1.000 1.000 06003491 6 Soybean, soy milk - babyfood or in 0.170000 1.000 1.000 06003500 6 Soybean, oil 0.170000 1.000 1.000 06003501 6 Soybean, oil - babyfood 0.170000 1.000 1.000 060104 30 6A Bean, snap, succulent 0.030000 1.000 1.000 06010431 6A Bean, snap, succulent - babyfood 0.030000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.030000 1.000 1.000 06020310 6B Bean, broad, succulent 0.030000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.030000 1.000 1.000 06020370 6B Bean, lima, succulent 0.030000 1.000 1.000 06022550 6B Pea, succulent 0.030000 1.000 1 .000 06022551 6B Pea, succulent - babyfood 0.030000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.030000 1.000 1.000 06030300 6C Bean, black, seed 0.510000 1.000 1.000 06030320 6C Bean, broa d, seed 0.510000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.510000 1.000 1.000 06030350 6C Bean, great northern, seed 0.510000 1.000 1.000 06030360 6C Bean, kidney, seed 0.5100 00 1.000 1.000 06030380 6C Bean, lima, seed 0.510000 1.000 1.000 06030390 6C Bean, mung, seed 0.510000 1.000 1.000 06030400 6C Bean, navy, seed 0.510000 1.000 1.000 06030410 6C Bean, pink, seed 0.510000 1.000 1.000 06030420 6C Bean, pinto, seed 0.510000 1.000 1.000 06030980 6C Chickpea, seed 0.510000 1.000 1.000 06030981 6C Chickpea, seed - babyfood 0.510000 1.000 1.000 06030990 6C Chickpea, flour 0.510000 1.000 1.000 06031820 6C Guar, seed 0.510000 1.000 1.000 06031821 6C Guar, seed - babyfo od 0.510000 1.000 1.000 06032030 6C Lentil, seed 0.510000 1.000 1.000 06032560 6C Pea, dry 0.510000 1.000 1.000 06032561 6C Pea, dry - babyfood 0.510000 1. 000 1.000 06032580 6C Pea, pigeon, seed 0.510000 1.000 1.000 10001060 10 Citrus citron 0.030000 1.000 1.000 10001070 10 Citrus hybrids 0.030000 1.000 1.000 10001080 10 Citr us, oil 0.030000 1.000 1.000 10001800 10 Grapefruit 0.030000 1.000 1.000 10001810 10 Grapefruit, juice 0.030000 2.100 1.000 10001970 10 Kumquat 0.030000 1.000 1.000 10001990 10 Lemon 0.030000 1.000 1.000 10002000 10 Lemon, juice 0.030000 2.000 1.000 10002001 10 Lemon, juice - babyfood 0.030000 2.000 1.000 10002 010 10 Lemon, peel 0.030000 1.000 1.000 10002060 10 Lime 0.030000 1.000 1.000 10002070 10 Lime, juice 0.030000 2.000 1.000 10002071 10 Lime, juice - babyfood 0.030000 2.000 1.000 10002400 10 Orange 0.030000 1.000 1.000 10002410 10 Orange, juice 0.030000 1.800 1.000 10002411 10 Orange, juice - babyfood 0.030000 1.800 1.000 10002420 10 Orange, peel 0.030000 1.000 1.000 10003070 10 Pummelo 0.030000 1.000 1.000 10003690 10 Tangerine 0.030000 1.000 1.000 10003700 10 Tangerine , juice 0.030000 1.000 1.000 11000070 11 Apple, fruit with peel 0.030000 1.000 1.000 11000080 11 Apple, peeled fruit 0.030000 1.000 1.000 11000081 11 Apple, peeled fruit - babyfood 0.030000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 10 of 18 11000090 11 Apple, dried 0.030000 8.000 1.000 11000091 11 Apple, dried - babyfood 0.030000 8.000 1.000 11000100 11 Apple, juice 0.030000 1.300 1.000 11000101 11 Apple, juice - babyfood 0.030000 1.300 1.000 11000110 11 Apple, sauce 0.030000 1.000 1.000 11000111 11 Apple, sauce - babyfood 0.030000 1. 000 1.000 11001290 11 Crabapple 0.030000 1.000 1.000 11002100 11 Loquat 0.030000 1.000 1.000 11002660 11 Pear 0.030000 1.000 1.000 11002661 11 Pear - babyfood 0.030000 1.000 1.000 11002670 11 Pear, dried 0.030000 6.250 1.000 11002680 11 Pear, juice 0.030000 1.000 1.000 11002681 11 Pear, juice - babyfood 0.030000 1.000 1.000 11003100 11 Quince 0.030000 1.000 1.000 12000120 12 Apricot 0.030000 1.000 1.000 12000121 12 Apricot - babyfood 0.030000 1.000 1.000 12000 130 12 Apricot, dried 0.030000 6.000 1.000 12000140 12 Apricot, juice 0.030000 1.000 1.000 12000141 12 Apricot, juice - babyfood 0.030000 1.000 1.000 12000900 12 Cherry 0.030000 1.000 1.000 12000901 12 Cherry - babyfood 0.030000 1.000 1.000 12000910 12 Cherry, juice 0.030000 1.500 1.000 12000911 12 Cherry, juice - babyfood 0.030000 1.500 1.000 12002300 12 Nectarine 0.030000 1.000 1.000 12002600 12 Peach 0.030000 1.000 1.000 12002601 12 Peach - babyfood 0.030000 1.000 1.000 12002610 12 Peach, dried 0.030000 7.000 1.000 12002611 12 Peach, dried - babyfood 0.030000 7.000 1.000 12002620 12 Peach, juice 0.030000 1.500 1.000 12002621 12 Peach, juice - baby food 0.030000 1.500 1.000 12002850 12 Plum 0.030000 1.000 1.000 12002851 12 Plum - babyfood 0.030000 1.000 1.000 12002860 12 Plum, prune, fresh 0.030000 1. 000 1.000 12002861 12 Plum, prune, fresh - babyfood 0.030000 1.000 1.000 12002870 12 Plum, prune, dried 0.030000 5.000 1.000 12002871 12 Plum, prune, dried - babyfood 0.030000 5.000 1.000 12002880 12 Plum , prune, juice 0.030000 1.400 1.000 12002881 12 Plum, prune, juice - babyfood 0.030000 1.400 1.000 14000030 14 Almond 0.030000 1.000 1.000 14000031 14 Almond - babyfood 0.030000 1.000 1.000 14000040 14 Almond, oil 0.030000 1.000 1.000 14000041 14 Almond, oil - babyfood 0.030000 1.000 1.000 14000590 14 Brazil nut 0.030000 1.000 1.000 14000 680 14 Butternut 0.030000 1.000 1.000 14000810 14 Cashew 0.030000 1.000 1.000 14000920 14 Chestnut 0.030000 1.000 1.000 14001550 14 Filbert 0.030000 1.000 1.000 14001560 14 Filbert, oil 0.030000 1.000 1.000 14001850 14 Hickory nut 0.030000 1.000 1.000 14002130 14 Macadamia nut 0.030000 1.000 1.000 14002690 14 Pecan 0.030000 1.000 1.000 14002820 14 Pistachio 0.030000 1.000 1.000 14003910 14 Walnut 0.030000 1.000 1.000 15000250 15 Barley, p earled barley 0.030000 1.000 1.000 15000251 15 Barley, pearled barley - babyfood 0.030000 1.000 1.000 15000260 15 Barley, flour 0.030000 1.000 1.000 15000261 15 Barley, flour - babyfood 0.030000 1.000 1.000 15000270 15 Barley, bran 0.030000 1.000 1.000 15000650 15 Buckwheat 0.030000 1.000 1.000 15000660 15 Buckwheat, flour 0.030000 1.000 1.000 15001200 15 Corn, field, flour 0.030000 1.000 1.000 15001201 15 Corn, field, flour - babyfood 0.030000 1.000 1.000 15001210 15 Corn, field, meal 0.030000 1. 000 1.000 15001211 15 Corn, field, meal - babyfood 0.030000 1.000 1.000 15001220 15 Corn, field, bran 0.030000 1.000 1.000 15001230 15 Corn, field, starch 0.030000 1.000 1.000 15001231 15 Corn , field, starch - babyfood 0.030000 1.000 1.000 15001240 15 Corn, field, syrup 0.030000 1.500 1.000 15001241 15 Corn, field, syrup - babyfood 0.030000 1.500 1.000 15001250 15 Corn, field, oil 0.030000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 11 of 18 15001251 15 Corn, field, oil - babyfood 0.030000 1.000 1.000 15001260 15 Corn, pop 0.030000 1.000 1.000 15001270 15 Corn, sweet 0.030000 1.000 1.000 15001 271 15 Corn, sweet - babyfood 0.030000 1.000 1.000 15002260 15 Millet, grain 0.030000 1.000 1.000 15002310 15 Oat, bran 0.030000 1.000 1.000 15002320 15 Oat, flour 0.030000 1.000 1.000 15002321 15 Oat, flour - babyfood 0.030000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.030000 1.000 1.000 15002331 15 Oat, groats/rolled oats - babyfood 0.030000 1.000 1.000 15003230 15 Rice, white 0.030000 1.000 1.000 15003231 15 Rice, white - babyfood 0.030000 1.000 1.000 15003240 15 Rice, brown 0.030000 1.000 1.000 15003241 15 Rice, bro wn - babyfood 0.030000 1.000 1.000 15003250 15 Rice, flour 0.030000 1.000 1.000 15003251 15 Rice, flour - babyfood 0.030000 1.000 1.000 15003260 15 Rice, bran 0.030000 1.000 1.000 15003261 15 Rice, bran - babyfood 0.030000 1.000 1.000 15003280 15 Rye, grain 0.030000 1.000 1.000 15003290 15 Rye, flour 0.030000 1.000 1.000 15003440 15 Sorghum, grain 0.030000 1.000 1.000 15003450 15 Sorghum, syrup 0.030000 1.000 1.000 15003810 15 Triticale, flour 0.030000 1. 000 1.000 15003811 15 Triticale, flour - babyfood 0.030000 1.000 1.000 15004010 15 Wheat, grain 0.030000 1.000 1.000 15004011 15 Wheat, grain - babyfood 0.030000 1.000 1.000 15004020 15 Whea t, flour 0.030000 1.000 1.000 15004021 15 Wheat, flour - babyfood 0.030000 1.000 1.000 15004030 15 Wheat, germ 0.030000 1.000 1.000 15004040 15 Wheat, bran 0.030000 1.000 1.000 15004050 15 Wild rice 0.030000 1.000 1.000 20001630 20 Flaxseed, oil 0.760000 1.000 1.000 20003190 20 Rapeseed, oil 0.760000 1.000 1.000 20003 191 20 Rapeseed, oil - babyfood 0.760000 1.000 1.000 20003300 20 Safflower, oil 1.700000 1.000 1.000 20003301 20 Safflower, oil - babyfood 1.700000 1.000 1.000 20003640 20 Sunflower, seed 1.700000 1.000 1.000 20003650 20 Sunflower, oil 1.700000 1.000 1.000 20003651 20 Sunflower, oil - babyfood 1.700000 1.000 1.000 21000440 M Beef, meat 0.010000 1.000 1.000 21000441 M Beef, meat - babyfood 0.010000 1.000 1.000 21000450 M Beef, meat, dried 0.010000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts - babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.010000 1.000 1.000 21000471 M Beef,fat - babyfood 0.010000 1.000 1.000 21000480 M Beef, kidney 0.050000 1.000 1.000 21000490 M Beef, liver 2.500000 1.000 1.000 21000491 M Beef, liver - babyfood 2.500000 1.000 1.000 23001690 M Goat, meat 0.010000 1. 000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.010000 1.000 1.000 23001720 M Goat, kidney 0.050000 1.000 1.000 23001730 M Goat , liver 2.500000 1.000 1.000 24001890 M Horse, meat 0.010000 1.000 1.000 25002900 M Pork, meat 0.010000 1.000 1.000 25002901 M Pork, meat - babyfood 0.010000 1.000 1.000 25002910 M Pork, skin 0.010000 1.000 1.000 25002920 M Pork, meat byproducts 0.020000 1.000 1.000 25002921 M Pork, meat byproducts - babyfood 0.020000 1.000 1.000 25002 930 M Pork, fat 0.010000 1.000 1.000 25002931 M Pork, fat - babyfood 0.010000 1.000 1.000 25002940 M Pork, kidney 0.010000 1.000 1.000 25002950 M Pork, liver 0.800000 1.000 1.000 26003390 M Sheep, meat 0.010000 1.000 1.000 26003391 M Sheep, meat - babyfood 0.010000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.010000 1.000 1.000 26003411 M Sheep, fat - babyfood 0.010000 1.000 1.000 26003420 M Sheep, kidney 0.050000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 12 of 18 26003430 M Sheep, li ver 2.500000 1.000 1.000 27002220 D Milk, fat 0.010000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 27012230 D Milk, nonfat solids 0.010000 1.000 1.000 27012231 D Milk, nonfat solids - baby food/in 0.010000 1.000 1.000 27022240 D Milk, water 0.010000 1.000 1.000 27022241 D Milk, water - babyf ood/infant form 0.010000 1.000 1.000 27032251 D Milk, sugar (lactose) - baby food/ 0.010000 1.000 1.000 29003120 M Rabbit, meat 0.010000 1.000 1.000 86010000 O Water, direct, all sources 0.180000 1. 000 1.000 86020000 O Water, indirect, all sources 0.180000 1.000 1.000 95000230 O Banana 0.030000 1.000 1.000 95000231 O Banana - babyfood 0.030000 1.000 1.000 95000240 O Bana na, dried 0.030000 3.900 1.000 95000241 O Banana, dried - babyfood 0.030000 3.900 1.000 95001150 O Coffee, roasted bean 0.030000 1.000 1.000 95001160 O Coffee, instant 0.030000 1.000 1.000 95001280 O Cottonseed, oil 0.340000 1.000 1.000 95001281 O Cottonseed, oil - babyfood 0.340000 1.000 1.000 95001750 O Grape 0.030000 1.000 1.000 95001 760 O Grape, juice 0.030000 1.200 1.000 95001761 O Grape, juice - babyfood 0.030000 1.200 1.000 95001770 O Grape, leaves 0.030000 1.000 1.000 95001780 O Grape, raisin 0.030000 4.300 1.000 95001790 O Grape, wine and sherry 0.030000 1.000 1.000 95002150 O Mango 0.030000 1.000 1.000 95002160 O Mango, dried 0.030000 1.000 1.000 95002170 O Mango, juice 0.030000 1.000 1.000 95002171 O Mango, juice - babyfood 0.030000 1.000 1.000 95003360 O Sesame, seed 0.760000 1.000 1.000 95003361 O Sesame, s eed - babyfood 0.760000 1.000 1.000 95003370 O Sesame, oil 0.760000 1.000 1.000 95003371 O Sesame, oil - babyfood 0.760000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 13 of 18 Acute Results File. U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for SAFLUFENACIL (1994 - 98 data) Residue file: Saflufenacil_Acute.R98 Adjustment factor #2 used. Analysis Date: 07 - 14 - 2011/15:27:20 Residue file dated: 07 - 14 - 2011/14:09:07/8 Daily totals for food and foodform consumption used. Run Comment: ""

=============================================================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population: 0.010415 0 .21 0.019031 0.38 0.037230 0.74 All infants: 0.038388 0.77 0.054734 1.09 0.095501 1.91 Children 1 - 2 yrs: 0.017262 0.35 0.028555 0.57 0.040967 0.82 Children 3 - 5 yrs : 0.015438 0.31 0.023025 0.46 0.039569 0.79 Children 6 - 12 yrs: 0.010471 0.21 0.017194 0.34 0.026015 0.52 Youth 13 - 19 yrs: 0.008451 0.17 0.013822 0.28 0.023396 0.47 Adults 20 - 49 yrs: 0.009266 0.19 0.015264 0.31 0.027095 0.54 Adults 50+ yrs: 0.008388 0.17 0.011916 0.24 0.019613 0.39 Females 13 - 49 yrs: 0.009336 0.19 0.014984 0.30 0.025487 0.51Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 14 of 18 Chronic Food plus Water Residue Input File. Filename: C: \ Documents and Settings \ gkramer \ My Documents \ Gk \ ##Saflufenacil new \ 0E7806 \ Sa flufenacil_ Chronic .R98 Chemical: Saflufenacil RfD(Chronic): .046 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 03 - 18 - 2011/10:48:46/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------ ------------------------- ---------- ------ ------ ------- 06003470 6 Soybean, seed 0.170000 1.000 1.000 06003480 6 Soybean, flour 0.170000 1.000 1.000 06003481 6 Soybean, flour - babyfood 0.170000 1.000 1.000 06003490 6 Soybean, soy milk 0.170000 1.000 1.000 06003491 6 Soybean, soy milk - babyfood or in 0.170000 1.000 1.000 06003500 6 Soybean, oil 0.170000 1.000 1.000 06003501 6 Soybean, oil - babyfood 0.170000 1.000 1.000 06010430 6A Bean, snap, succulent 0.030000 1.000 1.000 06010431 6A Bean, snap, succulent - babyfood 0.030000 1. 000 1.000 06012570 6A Pea, edible podded, succulent 0.030000 1.000 1.000 06020310 6B Bean, broad, succulent 0.030000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.030000 1.000 1.000 06020370 6B Bean , lima, succulent 0.030000 1.000 1.000 06022550 6B Pea, succulent 0.030000 1.000 1.000 06022551 6B Pea, succulent - babyfood 0.030000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.030000 1.000 1.000 06030300 6C Bean, black, seed 0.510000 1.000 1.000 06030320 6C Bean, broad, seed 0.510000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.510000 1.000 1.000 06030 350 6C Bean, great northern, seed 0.510000 1.000 1.000 06030360 6C Bean, kidney, seed 0.510000 1.000 1.000 06030380 6C Bean, lima, seed 0.510000 1.000 1.000 06030390 6C Bean, mung, seed 0.510000 1.000 1.000 06030400 6C Bean, navy, seed 0.510000 1.000 1.000 06030410 6C Bean, pink, seed 0.510000 1.000 1.000 06030420 6C Bean, pinto, seed 0.510000 1.000 1.000 06030980 6C Chickpea, seed 0.510000 1.000 1.000 06030981 6C Chickpea, seed - babyfood 0.510000 1.000 1.000 06030990 6C Chickpea, flour 0.510000 1.000 1.000 06031820 6C Guar, seed 0.510000 1.000 1.000 06031821 6C Guar, seed - babyfood 0.510000 1.000 1.000 06032030 6C Lentil, seed 0.510000 1.000 1.000 06032560 6C Pea, dry 0.510000 1.000 1.000 06032561 6C Pea, dry - babyfood 0.510000 1.000 1.000 06032580 6C Pea, pigeon, seed 0.510000 1.000 1.000 10001060 10 Citrus citron 0.030000 1. 000 1.000 10001070 10 Citrus hybrids 0.030000 1.000 1.000 10001080 10 Citrus, oil 0.030000 1.000 1.000 10001800 10 Grapefruit 0.030000 1.000 1.000 10001810 10 Grap efruit, juice 0.030000 2.100 1.000 10001970 10 Kumquat 0.030000 1.000 1.000 10001990 10 Lemon 0.030000 1.000 1.000 10002000 10 Lemon, juice 0.030000 2.000 1.000 10002001 10 Lemon, juice - babyfood 0.030000 2.000 1.000 10002010 10 Lemon, peel 0.030000 1.000 1.000 10002060 10 Lime 0.030000 1.000 1.000 10002 070 10 Lime, juice 0.030000 2.000 1.000 10002071 10 Lime, juice - babyfood 0.030000 2.000 1.000 10002400 10 Orange 0.030000 1.000 1.000 10002410 10 Orange, juice 0.030000 1.800 1.000 10002411 10 Orange, juice - babyfood 0.030000 1.800 1.000 10002420 10 Orange, peel 0.030000 1.000 1.000 10003070 10 Pummelo 0.030000 1.000 1.000 10003690 10 Tangerine 0.030000 1.000 1.000 10003700 10 Tangerine, juice 0.030000 1.000 1.000 11000070 11 Apple, fruit with peel 0.030000 1.000 1.000 11000080 11 Apple, pe eled fruit 0.030000 1.000 1.000 11000081 11 Apple, peeled fruit - babyfood 0.030000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 15 of 18 11000090 11 Apple, dried 0.030000 8.000 1.000 11000091 11 Apple, dried - babyfood 0.030000 8.000 1.000 11000100 11 Apple, juice 0.030000 1.300 1.000 11000101 11 Apple, juice - babyfood 0.030000 1.300 1.000 11000110 11 Apple, sauce 0.030000 1.000 1.000 11000111 11 Apple, sauce - babyfood 0.030000 1.000 1.000 11001290 11 Crabapple 0.030000 1.000 1.000 11002100 11 Loquat 0.030000 1. 000 1.000 11002660 11 Pear 0.030000 1.000 1.000 11002661 11 Pear - babyfood 0.030000 1.000 1.000 11002670 11 Pear, dried 0.030000 6.250 1.000 11002680 11 Pear , juice 0.030000 1.000 1.000 11002681 11 Pear, juice - babyfood 0.030000 1.000 1.000 11003100 11 Quince 0.030000 1.000 1.000 12000120 12 Apricot 0.030000 1.000 1.000 12000121 12 Apricot - babyfood 0.030000 1.000 1.000 12000130 12 Apricot, dried 0.030000 6.000 1.000 12000140 12 Apricot, juice 0.030000 1.000 1.000 12000 141 12 Apricot, juice - babyfood 0.030000 1.000 1.000 12000900 12 Cherry 0.030000 1.000 1.000 12000901 12 Cherry - babyfood 0.030000 1.000 1.000 12000910 12 Cherry, juice 0.030000 1.500 1.000 12000911 12 Cherry, juice - babyfood 0.030000 1.500 1.000 12002300 12 Nectarine 0.030000 1.000 1.000 12002600 12 Peach 0.030000 1.000 1.000 12002601 12 Peach - babyfood 0.030000 1.000 1.000 12002610 12 Peach, dried 0.030000 7.000 1.000 12002611 12 Peach, dried - babyfood 0.030000 7.000 1.000 12002620 12 Peach, ju ice 0.030000 1.500 1.000 12002621 12 Peach, juice - babyfood 0.030000 1.500 1.000 12002850 12 Plum 0.030000 1.000 1.000 12002851 12 Plum - babyfood 0.030000 1.000 1.000 12002860 12 Plum, prune, fresh 0.030000 1.000 1.000 12002861 12 Plum, prune, fresh - babyfood 0.030000 1.000 1.000 12002870 12 Plum, prune, drie d 0.030000 5.000 1.000 12002871 12 Plum, prune, dried - babyfood 0.030000 5.000 1.000 12002880 12 Plum, prune, juice 0.030000 1.400 1.000 12002881 12 Plum, prune, juice - babyfood 0.030000 1. 400 1.000 14000030 14 Almond 0.030000 1.000 1.000 14000031 14 Almond - babyfood 0.030000 1.000 1.000 14000040 14 Almond, oil 0.030000 1.000 1.000 14000041 14 Almo nd, oil - babyfood 0.030000 1.000 1.000 14000590 14 Brazil nut 0.030000 1.000 1.000 14000680 14 Butternut 0.030000 1.000 1.000 14000810 14 Cashew 0.030000 1.000 1.000 14000920 14 Chestnut 0.030000 1.000 1.000 14001550 14 Filbert 0.030000 1.000 1.000 14001560 14 Filbert, oil 0.030000 1.000 1.000 14001 850 14 Hickory nut 0.030000 1.000 1.000 14002130 14 Macadamia nut 0.030000 1.000 1.000 14002690 14 Pecan 0.030000 1.000 1.000 14002820 14 Pistachio 0.030000 1.000 1.000 14003910 14 Walnut 0.030000 1.000 1.000 15000250 15 Barley, pearled barley 0.030000 1.000 1.000 15000251 15 Barley, pearled barley - babyfood 0.030000 1.000 1.000 15000260 15 Barley, flour 0.030000 1.000 1.000 15000261 15 Barley, flour - babyfood 0.030000 1.000 1.000 15000270 15 Barley, bran 0.030000 1.000 1.000 15000650 15 Buckwheat 0.030000 1.000 1.000 15000660 15 Buckwheat, flour 0.030000 1.000 1.000 15001200 15 Corn, field, flour 0.030000 1.000 1.000 15001201 15 Corn, field, flou r - babyfood 0.030000 1.000 1.000 15001210 15 Corn, field, meal 0.030000 1.000 1.000 15001211 15 Corn, field, meal - babyfood 0.030000 1.000 1.000 15001220 15 Corn, field, bran 0.030000 1. 000 1.000 15001230 15 Corn, field, starch 0.030000 1.000 1.000 15001231 15 Corn, field, starch - babyfood 0.030000 1.000 1.000 15001240 15 Corn, field, syrup 0.030000 1.500 1.000 15001241 15 Corn , field, syrup - babyfood 0.030000 1.500 1.000 15001250 15 Corn, field, oil 0.030000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 16 of 18 15001251 15 Corn, field, oil - babyfood 0.030000 1.000 1.000 15001260 15 Corn, pop 0.030000 1.000 1.000 15001270 15 Corn, sweet 0.030000 1.000 1.000 15001271 15 Corn, sweet - babyfood 0.030000 1.000 1.000 15002260 15 Millet, grain 0.030000 1.000 1.000 15002 310 15 Oat, bran 0.030000 1.000 1.000 15002320 15 Oat, flour 0.030000 1.000 1.000 15002321 15 Oat, flour - babyfood 0.030000 1.000 1.000 15002330 15 Oat, groats/rolled oat s 0.030000 1.000 1.000 15002331 15 Oat, groats/rolled oats - babyfood 0.030000 1.000 1.000 15003230 15 Rice, white 0.030000 1.000 1.000 15003231 15 Rice, white - babyfood 0.030000 1.000 1.000 15003240 15 Rice, brown 0.030000 1.000 1.000 15003241 15 Rice, brown - babyfood 0.030000 1.000 1.000 15003250 15 Rice, flour 0.030000 1.000 1.000 15003251 15 Rice, flo ur - babyfood 0.030000 1.000 1.000 15003260 15 Rice, bran 0.030000 1.000 1.000 15003261 15 Rice, bran - babyfood 0.030000 1.000 1.000 15003280 15 Rye, grain 0.030000 1.000 1.000 15003290 15 Rye, flour 0.030000 1.000 1.000 15003440 15 Sorghum, grain 0.030000 1.000 1.000 15003450 15 Sorghum, syrup 0.030000 1.000 1.000 15003810 15 Triticale, flour 0.030000 1.000 1.000 15003811 15 Triticale, flour - babyfood 0.030000 1.000 1.000 15004010 15 Wheat, grain 0.030000 1. 000 1.000 15004011 15 Wheat, grain - babyfood 0.030000 1.000 1.000 15004020 15 Wheat, flour 0.030000 1.000 1.000 15004021 15 Wheat, flour - babyfood 0.030000 1.000 1.000 15004030 15 Whea t, germ 0.030000 1.000 1.000 15004040 15 Wheat, bran 0.030000 1.000 1.000 15004050 15 Wild rice 0.030000 1.000 1.000 20001630 20 Flaxseed, oil 0.760000 1.000 1.000 20003190 20 Rapeseed, oil 0.760000 1.000 1.000 20003191 20 Rapeseed, oil - babyfood 0.760000 1.000 1.000 20003300 20 Safflower, oil 1.700000 1.000 1.000 20003 301 20 Safflower, oil - babyfood 1.700000 1.000 1.000 20003640 20 Sunflower, seed 1.700000 1.000 1.000 20003650 20 Sunflower, oil 1.700000 1.000 1.000 20003651 20 Sunflower, oil - babyfoo d 1.700000 1.000 1.000 21000440 M Beef, meat 0.010000 1.000 1.000 21000441 M Beef, meat - babyfood 0.010000 1.000 1.000 21000450 M Beef, meat, dried 0.010000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts - babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.010000 1.000 1.000 21000471 M Beef,fat - babyfood 0.010000 1.000 1.000 21000480 M Beef, kidney 0.050000 1.000 1.000 21000490 M Beef, liver 2.500000 1.000 1.000 21000491 M Beef, liver - babyfood 2.500000 1.000 1.000 23001690 M Goat, meat 0.010000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.010000 1.000 1.000 23001720 M Goat, kidney 0.050000 1.000 1.000 23001730 M Goat, liver 2.500000 1.000 1.000 24001890 M Horse, meat 0.010000 1. 000 1.000 25002900 M Pork, meat 0.010000 1.000 1.000 25002901 M Pork, meat - babyfood 0.010000 1.000 1.000 25002910 M Pork, skin 0.010000 1.000 1.000 25002920 M Pork , meat byproducts 0.020000 1.000 1.000 25002921 M Pork, meat byproducts - babyfood 0.020000 1.000 1.000 25002930 M Pork, fat 0.010000 1.000 1.000 25002931 M Pork, fat - babyfood 0.010000 1.000 1.000 25002940 M Pork, kidney 0.010000 1.000 1.000 25002950 M Pork, liver 0.800000 1.000 1.000 26003390 M Sheep, meat 0.010000 1.000 1.000 26003 391 M Sheep, meat - babyfood 0.010000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.010000 1.000 1.000 26003411 M Sheep, fat - babyfood 0.010000 1.000 1.000 26003420 M Sheep, kidney 0.050000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 17 of 18 26003430 M Sheep, liver 2.500000 1.000 1.000 27002220 D Milk, fat 0.010000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 27012230 D Milk, nonfat solids 0.010000 1.000 1.000 27012231 D Milk, nonfat solids - baby food/in 0.010000 1.000 1.000 27022240 D Milk, water 0.010000 1.000 1.000 27022241 D Milk, water - babyfood/infant form 0.010000 1.000 1.000 27032251 D Milk, sugar (lactose) - baby food/ 0.010000 1.000 1.000 29003120 M Rabbit, meat 0.010000 1.000 1.000 86010000 O Water, direct, all sources 0.1 73 000 1.000 1.000 86020000 O Water, indirect, all sources 0.1 73 000 1.000 1.000 95000230 O Banana 0.030000 1. 000 1.000 95000231 O Banana - babyfood 0.030000 1.000 1.000 95000240 O Banana, dried 0.030000 3.900 1.000 95000241 O Banana, dried - babyfood 0.030000 3.900 1.000 95001150 O Coff ee, roasted bean 0.030000 1.000 1.000 95001160 O Coffee, instant 0.030000 1.000 1.000 95001280 O Cottonseed, oil 0.340000 1.000 1.000 95001281 O Cottonseed, oil - babyfood 0.340000 1.000 1.000 95001750 O Grape 0.030000 1.000 1.000 95001760 O Grape, juice 0.030000 1.200 1.000 95001761 O Grape, juice - babyfood 0.030000 1.200 1.000 95001 770 O Grape, leaves 0.030000 1.000 1.000 95001780 O Grape, raisin 0.030000 4.300 1.000 95001790 O Grape, wine and sherry 0.030000 1.000 1.000 95002150 O Mango 0.030000 1.000 1.000 95002160 O Mango, dried 0.030000 1.000 1.000 95002170 O Mango, juice 0.030000 1.000 1.000 95002171 O Mango, juice - babyfood 0.030000 1.000 1.000 95003360 O Sesame, seed 0.760000 1.000 1.000 95003361 O Sesame, seed - babyfood 0.760000 1.000 1.000 95003370 O Sesame, oil 0.760000 1.000 1.000 95003371 O Sesame, o il - babyfood 0.760000 1.000 1.000Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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### Page 18 of 18 Chronic Results File. .S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for SAFLUFENACIL (1994 - 98 data) Residue file name: C: \ Documents and Settings \ gkramer \ My Documents \ Gk \ ##Saflufenacil new \ 0E7806 \ Saflufenacil_Chronic.R98 Adjustment factor #2 used. Analysis Date 07 - 14 - 2011/14:09:51 Residue file dated: 07 - 14 - 2011/14:07: 35/8 Reference dose (RfD, Chronic) = .046 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

--------------------------------------------------------------- ---------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgro up body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.004232 9.2% U.S. Population (spring season) 0.004195 9.1% U.S. Population (summer season) 0.004498 9.8% U.S. Population (autumn season) 0.004115 8.9% U.S. Population (winter season) 0.004116 8.9% Nor theast region 0.003915 8.5% Midwest region 0.004270 9.3% Southern region 0.004020 8.7% Western region 0.004814 10.5% Hispanics 0.004896 10.6% Non - hispanic whites 0.004107 8.9% Non - hispanic blacks 0.004075 8 .9% Non - hisp/non - white/non - black 0.005158 11.2% All infants (< 1 year) 0.014043 30.5% Nursing infants 0.005194 11.3% Non - nursing infants 0.017401 37.8% Children 1 - 6 yrs 0.006649 14.5% Children 7 - 12 yrs 0.004146 9.0% Females 13 - 19 (not preg or nursing) 0.003045 6.6% Females 20+ (not preg or nursing) 0.004018 8.7% Females 13 - 50 yrs 0.003997 8.7% Females 13+ (preg/not nursing) 0.004046 8.8% Females 13+ (nursing) 0.005640 12.3% Males 13 - 19 yrs 0.003256 7.1% Males 20+ yrs 0.003690 8.0% Seniors 55+ 0.003953 8.6% Children 1 - 2 yrs 0.007290 15.8% Children 3 - 5 yrs 0.006535 14.2% Children 6 - 12 yrs 0.004383 9.5% Youth 13 - 19 yr s 0.003164 6.9% Adults 20 - 49 yrs 0.003821 8.3% Adults 50+ yrs 0.003959 8.6% Females 13 - 49 yrs 0.00 3802 8.3%

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