Exhibit 4.2

   

  EXECUTION COPY

   

  THERMO FISHER SCIENTIFIC INC.,

  as Issuer

   

  AND

   

  THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,

  

  as Trustee

   

  TWENTY-FIFTH SUPPLEMENTAL INDENTURE

  

  Dated as of November 21, 2022

   

  3.200% Senior Notes due 2026

   

  3.650% Senior Notes due 2034

   

  
    

    
      
 

  

   

  THIS TWENTY-FIFTH SUPPLEMENTAL INDENTURE (this “Supplemental

        Indenture”) is dated as of November 21, 2022 between THERMO FISHER SCIENTIFIC INC., a Delaware corporation (the “Company”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association, as trustee (the “Trustee”).

   

  RECITALS

   

  WHEREAS, the Company and the Trustee executed and delivered an Indenture, dated as
      of November 20, 2009 (the “Base Indenture” and, as supplemented by this Supplemental Indenture, the “Indenture”), to provide for the issuance by the Company from time to time of unsubordinated debt securities evidencing its unsecured
      indebtedness.

   

  WHEREAS, the Company has authorized the issuance of €500,000,000 aggregate
      principal amount of the Company’s 3.200% Senior Notes due 2026 (the “2026 Notes”) and €750,000,000 aggregate principal amount of the Company’s 3.650% Senior Notes due 2034 (the “2034 Notes” and, together with the 2026 Notes, the “Notes”).

   

  WHEREAS, the entry into this Supplemental Indenture by the parties hereto is in all
      respects authorized by the provisions of the Base Indenture.

   

  WHEREAS, the Company desires to enter into this Supplemental Indenture pursuant to
      Section 9.01 of the Base Indenture to establish the terms of the Notes in accordance with Section 2.01 of the Base Indenture and to establish the form of the Notes in accordance with Sections 2.01(a)(10) and 2.02 of the Base Indenture.

   

  WHEREAS, all things necessary to make this Supplemental Indenture a valid and
      legally binding agreement according to its terms have been done.

   

  NOW, THEREFORE, for and in consideration of the foregoing premises, the Company and
      the Trustee, mutually covenant and agree for the equal and proportionate benefit of the respective Holders from time to time of the Notes as follows:

   

  ARTICLE I

   

  		Section 1.1	Defined Terms.


   

  (1)          Capitalized terms used but not defined in this Supplemental Indenture
      shall have the meanings ascribed thereto in the Base Indenture.

   

  (2)          A term defined anywhere in this Supplemental Indenture has the same
      meaning throughout.

   

  
    

    
      
 

  

   

  (3)         The singular includes the plural and vice versa.

   

  (4)         Headings are for convenience of reference only and do not affect the
      interpretation.

   

  (5)         As used herein, the following defined terms shall have the following
      meanings with respect to the Notes and this Supplemental Indenture only:

   

  “Additional Amounts” has the meaning set forth in Section
      1.5(2).

   

  “Below Investment Grade Rating Event” means, with respect to a series of
      Notes, such Notes are downgraded below an Investment Grade Rating by any two of the Rating Agencies on any date during the period (the “Trigger Period”) commencing 60 days prior to the first public announcement by the Company of the occurrence
      of a Change of Control (or pending Change of Control) and ending 60 days following consummation of such Change of Control (which Trigger Period shall be extended so long as the rating of such Notes is under publicly announced consideration for
      possible downgrade by at least two of such Rating Agencies on such 60th day, such extension to last with respect to each such Rating Agency until the date on which such Rating Agency considering such possible downgrade either (x) rates such Notes
      below an Investment Grade Rating or (y) publicly announces that it is no longer considering such Notes for possible downgrade, provided that no such extension will occur if on such 60th day such Notes have an Investment Grade Rating from at
      least two of such Rating Agencies in question and are not subject to review for possible downgrade by such Rating Agencies). The Trustee shall not be responsible for monitoring, or charged with knowledge of, the ratings of the Notes.

   

  “Business Day” means any day, other than a Saturday or
      Sunday, (1) which is not a day on which banking institutions in The City of New York or London are authorized or required by law, regulation or executive order to close and (2) on which the Trans-European Automated Real-Time Gross Settlement Express
      Transfer system (the TARGET2 system), or any successor thereto, is open.

   

  “Change of Control” means the occurrence of any of the following: (1) the
      direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its subsidiaries
      taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its direct or indirect wholly-owned subsidiaries; (2) the consummation of any transaction (including, without limitation,
      any merger or consolidation) as a result of which any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more
      than 50% of the Company’s outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares; (3) the Company consolidates
      with, or merges with or into, any “person” or “group” (as that term is used in Section 13(d)(3) of the Exchange Act), or any “person” or “group” consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in
      which any of the Company’s Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property, other than any such transaction where the shares of the Company’s Voting Stock outstanding
      immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any direct or indirect parent company of the surviving person immediately after giving effect to such
      transaction; or (4) the adoption of a plan relating to the Company’s liquidation or dissolution.

   

  

  
    

    
      
 

  

  
   

  Notwithstanding the foregoing, a transaction will not be deemed to involve a
      Change of Control if (a) the Company becomes a direct or indirect wholly owned subsidiary of a holding company (which shall include a parent company) and (b)(i) the holders of the Voting Stock of such holding company immediately following that
      transaction are substantially the same as the holders of the Voting Stock of the Company immediately prior to that transaction or (ii) no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) (other than a holding company satisfying
      the requirements of this sentence) becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the voting power of the Voting Stock of such holding company immediately
      following such transaction.

   

  “Change of Control Triggering Event” means, with respect to either series of
      Notes, the occurrence of both a Change of Control and a Below Investment Grade Rating Event.

   

  “Code” means the U.S. Internal Revenue Code of 1986, as amended.

   

  “Common Depositary” means The Bank of New York Mellon, London Branch, as
      common depositary for the Depositary.

   

  “Comparable Bond Rate” means, for any Optional Redemption Date, the rate
      per annum equal to the annual equivalent yield to maturity or interpolated yield to maturity (on a day count basis), computed as of the third Business Day immediately preceding that Optional Redemption Date, of the Comparable Government Issue,
      assuming a price for the Comparable Government Issue (expressed as a percentage of its principal amount) equal to the Comparable Price for that Optional Redemption Date.

   

  “Comparable Government Issue” means, with respect to either series of Notes
      to be redeemed, the euro-denominated security issued by the German government selected by an Independent Investment Banker as having an actual or interpolated maturity comparable to the remaining term of the applicable series of Notes to be redeemed
      (assuming that such Notes to be redeemed matured on their applicable Par Call Date) that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable
      maturity to the remaining term of the applicable series of Notes to be redeemed.

   

  “Comparable Price” means, with respect to any Optional Redemption Date, (a)
      the average of the Reference Dealer Quotations for such Optional Redemption Date, after excluding the highest and lowest of the Reference Dealer Quotations, (b) if the Company obtains fewer than four Reference Dealer Quotations, the arithmetic
      average of those quotations or (c) if the Company obtains only one Reference Dealer Quotation, such Reference Dealer Quotation.

   

  “Depositary” means each of Clearstream Banking, S.A. and Euroclear Bank SA/NV
      as operator of the Euroclear System.

   

  

  
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  “Electronic Means” shall mean the following communications methods: e-mail,
      facsimile transmission, secure electronic transmission containing applicable authorization codes, passwords and/or authentication keys issued by the Trustee, or another method or system specified by the Trustee as available for use in connection with
      its services hereunder.

   

  “euro” or “€” means the single currency introduced at the third stage
      of the European Economic and Monetary Union pursuant to the Treaty establishing the European Community, as amended.

   

  “Fitch” means Fitch Ratings Limited, and any successor to its rating agency
      business.

   

  “ICMA” means the International Capital Markets Association.

   

  “Independent Investment Banker” means one of the Reference Dealers appointed
      by the Company to act as Independent Investment Banker.

   

  “Investment Grade Rating” means a rating by Moody’s equal to or higher than
      Baa3 (or the equivalent under a successor rating category of Moody’s) or a rating by S&P equal to or higher than BBB- (or the equivalent under any successor rating category of S&P) or a rating by Fitch equal to or higher than BBB- (or the
      equivalent under any successor rating category of Fitch).

   

  “Moody’s” means Moody’s Investors Service, Inc., and any successor to its
      rating agency business.

   

  “Optional Redemption Date” when used with respect to any Note to be redeemed
      at the Company’s option, means the date fixed for such redemption by or pursuant to Section 1.3 of this Supplemental Indenture.

   

  “Optional Redemption Price” when used with respect to any Note to be redeemed
      at the Company’s option, means the price at which it is to be redeemed pursuant to Section 1.3 of this Supplemental Indenture.

   

  “Par Call Date” means December 21, 2025 in the case of the 2026 Notes; and
      August 21, 2034 in the case of the 2034 Notes.

   

  “Paying Agency Agreement” means the Paying Agency Agreement, dated as of
      November 21, 2022, between the Company and the Paying Agent.

   

  “Paying Agent” means The Bank of New York Mellon, London Branch, or any
      successor.

   

  “Primary Bond Dealer” means a broker or dealer of, and/or a market maker in,
      German government bonds.

   

  “Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any of
      Moody’s, S&P or Fitch ceases to rate the applicable series of Notes or fails to make a rating of such Notes publicly available for any reason, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the
      Exchange Act, selected by the Company (as certified by a resolution of its Board of Directors) as a replacement agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be.

   

  

  
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  “Reference Dealer” means each of (i) Citigroup Global Markets Limited,
      Deutsche Bank AG, London Branch and Merrill Lynch International and their respective affiliates or successors and (ii) one other nationally recognized investment banking firm (or its affiliate) that is a Primary Bond Dealer that the Company selects
      in connection with the particular redemption, and each of their respective successors, provided that if at any time any of the above is not a Primary Bond Dealer, the Company will substitute that entity with another nationally recognized
      investment banking firm that the Company selects that is a Primary Bond Dealer.

   

  “Reference Dealer Quotations” means, with respect to each Reference Dealer and
      any Optional Redemption Date, the arithmetic average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Government Issue (expressed in each case as a percentage of its principal amount) quoted in
      writing to the Independent Investment Banker by such Reference Dealer at 11:00 a.m., London time, on the third Business Day preceding such Optional Redemption Date.

   

  “Remaining Scheduled Payments” means, with respect to each Note to be
      redeemed, the remaining scheduled payments of the principal thereof and interest thereon that would be due after the related Optional Redemption Date but for such redemption (assuming that such Note to be redeemed matured on its applicable Par Call
      Date); provided, however, that, if such Optional Redemption Date is not an interest payment date with respect to such Note, the amount of the next succeeding scheduled interest payment thereon will be reduced by the amount of interest accrued
      thereon to such Optional Redemption Date.

   

  “S&P” means S&P Global Ratings, a division of S&P Global, Inc.,
      and any successor to its rating agency business.

   

  “Specified Office of the Paying Agent” means, initially, the London Branch of
      The Bank of New York Mellon, located at 160 Queen Victoria Street, London EC4V 4LA, England.

   

  “United States” means the United States of America, the states of the United
      States, and the District of Columbia.

   

  		Section 1.2	Terms of the Notes.


   

  The following terms relate to the Notes:

   

  (1)         The 2026 Notes shall constitute a separate series of Notes having the
      title “3.200% Senior Notes due 2026” and the 2034 Notes shall constitute a separate series of Notes having the title “3.650% Senior Notes due 2034.”

   

  

  
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  (2)         The aggregate principal amount of the 2026 Notes (the “Initial 2026
        Notes”) and the 2034 Notes (the “Initial 2034 Notes,” and, together with the Initial 2026 Notes, the “Initial Notes”) that may be initially authenticated and delivered under the Indenture shall be €500,000,000 and €750,000,000,
      respectively. The Company may from time to time, without giving notice to or seeking the consent of any Holders of Notes of such series, issue additional 2026 Notes (in any such case, the “Additional 2026 Notes”) and additional 2034 Notes (in
      any such case, the “Additional 2034 Notes,” and, together with the Additional 2026 Notes, the “Additional Notes”) having the same terms (except for the issue date, offering price and, if applicable, the first interest payment date) and
      ranking equally and ratably with the Initial 2026 Notes and the Initial 2034 Notes, as the case may be. Any Additional Notes of a series and the Initial Notes of such series shall constitute a single series under the Indenture; provided that
      if any Additional Notes of a series are not fungible with the Initial Notes of such series for U.S. federal income tax purposes, such Additional Notes of such series shall have separate ISIN and Common Code numbers. All references to a series of
      Notes shall include both the Initial Notes and any Additional Notes of such series, unless the context otherwise requires. The aggregate principal amount of each of the 2026 Notes and the 2034 Notes shall be unlimited.

   

  (3)          The entire respective Outstanding principal amount of the 2026 Notes
      and the 2034 Notes shall be payable on January 21, 2026 and November 21, 2034, respectively. The principal of each Note payable at maturity or upon earlier redemption shall be paid against presentation and surrender of such Note at the office or
      agency maintained for such purposes in London, initially, the Specified Office of the Paying Agent.

   

  (4)        The rate at which the 2026 Notes shall bear interest shall be 3.200%
      per annum and the rate at which the 2034 Notes shall bear interest shall be 3.650% per annum. The date from which interest shall accrue on the Notes shall be the most recent Interest Payment Date to which interest has been paid or provided for or, if
      no interest has been paid, from November 21, 2022. The Interest Payment Dates for the 2026 Notes shall be January 21 of each year, beginning on January 21, 2023 until the principal is paid or made available for payment, and the Interest Payment Dates
      for the 2034 Notes shall be November 21 of each year, beginning on November 21, 2023 until the principal is paid or made available for payment; provided that if any Interest Payment Date for either series of Notes falls on a day that is not
      a Business Day, the required payment shall be made on the next Business Day as if it were made on the date the payment to Holders was due and no interest shall accrue on the amount so payable for the period from and after that Interest Payment Date.
      The regular record date shall be the Business Day immediately preceding each Interest Payment Date. Interest on the Notes shall be computed by the Company on the basis of an ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of ICMA) day count
      convention.

   

  (5)          The Notes shall be issuable in whole in the form of one or more
      registered Global Securities, without coupons, which shall be deposited with, or on behalf of, the applicable Depositary and shall be registered in the name of the Common Depositary for, and in respect of interests held through, the applicable
      Depositary. Each Note shall be substantially in the form attached hereto as Exhibit A, the terms of which are herein incorporated by reference. The Notes shall be issuable in denominations of €100,000 or any integral multiple of €1,000 in
      excess thereof.

   

  

  
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  (6)          The Notes may be redeemed at the option of the Company prior to the
      maturity date, as provided in Section 1.3 and 1.4 hereof.

   

  (7)          The Notes shall not have the benefit of any
      sinking fund.

   

  (8)          Except as provided herein, the Holders shall have no special rights in
      addition to those provided in the Base Indenture upon the occurrence of any particular events.

   

  (9)         The Notes shall be general unsecured and unsubordinated obligations of
      the Company and shall be ranked equally among themselves.

   

  (10)       The Notes are not convertible into shares of common stock or other
      securities of the Company.

   

  (11)       The covenants set forth in Section 1.5 hereof
      shall be applicable to the Notes.

   

  (12)       The transfer and exchange provisions set forth in Section 2.05 of the
      Base Indenture shall be applicable to the Notes.

   

  (13)       All payments of principal of, and interest (including Additional
      Amounts, if any) and premium (if any) on, the Notes shall be payable in euro; provided, however, that if, on or after November 14, 2022, euro is unavailable to the Company due to the imposition of exchange controls or other circumstances
      beyond the Company’s control or if the euro is no longer being used by the then member states of the European Economic and Monetary Union that have adopted the euro as their currency or for the settlement of transactions by public institutions of or
      within the international banking community, then all payments in respect of the Notes shall be made in U.S. dollars until the euro is again available to the Company or so used. In such circumstances, the amount payable on any date in euro shall be
      converted into U.S. dollars at the rate mandated by the U.S. Federal Reserve Board as of the close of business on the second Business Day prior to the relevant payment date or, in the event the U.S. Federal Reserve Board has not mandated a rate of
      conversion, on the basis of the most recent U.S. dollar/euro exchange rate published in The Wall Street Journal on or prior to the second Business Day prior to the relevant payment date. Any payment in respect of the Notes so made in U.S.
      dollars shall not constitute an Event of Default under the Notes or the Indenture. Neither the Trustee nor the Paying Agent shall have any responsibility for any calculation or conversion in connection with the foregoing. Any references elsewhere in
      the Indenture or the Notes to payments being made in euro notwithstanding, payments shall be made in U.S. dollars to the extent set forth in this Section 1.2(13).

   

  (a)         The Bank of New York Mellon, London Branch, shall initially act as the
      Paying Agent in accordance with the terms of the Paying Agency Agreement. The Company hereby initially designates the Specified Office of the Paying Agent as the office to be maintained by it where Notes may be presented for payment, registration of
      transfer or exchange, and where notices to or demands upon the Company in respect of the Notes or the Indenture may be served. The Security Registrar for the Notes shall initially be the Trustee. Upon notice to the Trustee, the Company may at any
      time vary or terminate the appointment of any Paying Agent or Security Registrar, to appoint additional or other Paying Agents or Security Registrars and to approve any change in the office through which any Paying Agent or Security Registrar acts.

   

  

  
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  (14)        In order to provide for all payments due on the Notes as the same shall
      become due, the Company shall cause to be paid to the Paying Agent, no later than 10:00 a.m. London time on the Business Day prior to the payment date of each Note, at such bank as the Paying Agent shall previously have notified the Company, in
      immediately available funds sufficient to meet all payments due on such Notes.

      

    

   

  (15)        Notwithstanding any other provision of this Supplemental Indenture, the
      Trustee and Paying Agent shall be entitled to make a deduction or withholding from any payment which it makes under this Supplemental Indenture for or on account of any present or future taxes, duties or charges if and to the extent so required by
      any applicable law and any current or future regulations or agreements thereunder or official interpretations thereof or any law implementing an intergovernmental approach thereto or by virtue of the relevant Holder failing to satisfy any
      certification or other requirements in respect of the Notes, in which event the Trustee or Paying Agent shall make such payment after such withholding or deduction has been made and shall account to the relevant authorities for the amount so withheld
      or deducted and shall have no obligation to gross up any payment hereunder or pay any additional amount as a result of such withholding tax.

   

  		Section 1.3	Optional Redemption.


   

  (a)          The provisions of Article III of the Base Indenture, as amended by the
      provisions of this Supplemental Indenture, shall apply to the Notes with respect to this Section 1.3.

   

  (b)          Prior to their applicable Par Call Date, the Notes of either series
      shall be redeemable, in whole at any time or in part from time to time, at the Company’s option. Upon redemption of the Notes of either series, the Company shall pay an Optional Redemption Price equal to the greater of:

   

  		(i)	100% of the principal amount of the Notes of such series to be redeemed, and


   

  		(ii)	the sum of the present values of the Remaining Scheduled Payments of the Notes of such series to be
            redeemed, discounted to the Optional Redemption Date on an annual basis (ACTUAL/ACTUAL (ICMA)) using a discount rate equal to the Comparable Bond Rate, plus 20 basis points, in the case of the 2026 Notes, and 25 basis points, in the case of the
            2034 Notes;


   

  plus, in each case, in addition to such Optional Redemption Price, accrued
      and unpaid interest on the Notes being redeemed, if any, to, but excluding, the Optional Redemption Date.

   

  On and after the applicable Par Call Date, the Notes of either series shall be
      redeemable, in whole at any time or in part from time to time, at the Company’s option, at an Optional Redemption Price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding,
      the Optional Redemption Date.

   

  

  
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  (c)          Notwithstanding the foregoing, installments of interest on either series
      of Notes whose Stated Maturity is on or prior to the Optional Redemption Date shall be payable on the applicable Interest Payment Date to the Holders of such Notes registered as such at the close of business on the applicable regular record date
      pursuant to the Notes and the Indenture.

   

  (d)          On and after the applicable Optional Redemption Date for either series
      of Notes, interest shall cease to accrue on the Notes to be redeemed or any portion thereof called for redemption, unless the Company defaults in the payment of the Optional Redemption Price and accrued and unpaid interest and Additional Amounts, if
      any. No later than 10:00 a.m. London time on the Business Day prior to the Optional Redemption Date for any Notes to be redeemed, the Company shall deposit with the Trustee or Paying Agent, funds sufficient to pay the Optional Redemption Price of
      such Notes on the Optional Redemption Date, and (except if the date fixed for redemption shall be an Interest Payment Date) accrued and unpaid interest and Additional Amounts, if any. If less than all of the Notes of either series are to be redeemed,
      the Notes to be redeemed shall be selected, in the case of global securities, in accordance with applicable Depositary procedures and, in the case of definitive securities in a manner the trustee deems fair and appropriate, unless otherwise required
      by law or applicable stock exchange requirements.

   

  (e)           Notice of any optional redemption shall be transmitted at least 10 days
      but not more than 60 days before the applicable Optional Redemption Date to each Holder of the Notes to be redeemed; provided, however, that the Company shall notify the Trustee of the Optional Redemption Date at least 15 days prior to the
      date of the giving of such notice (unless a shorter notice shall be satisfactory to the Trustee). A notice of redemption may, at the discretion of the Company, be subject to one or more conditions precedent, including, but not limited to, completion
      of an equity offering, a financing, or other corporate transaction, provided that if such redemption or notice is subject to satisfaction of one or more conditions precedent, such notice shall state that, in the Company’s discretion, the Optional
      Redemption Date may be postponed until up to 60 days following the notice of redemption, and such notice may be rescinded in the event that any or all such conditions shall not have been satisfied by the Optional Redemption Date (including as it may
      be postponed). Such notice shall be provided in accordance with Section 3.02 of the Base Indenture. If the Optional Redemption Price cannot be determined at the time such notice is to be given, the actual Optional Redemption Price applicable to the
      Notes that are being redeemed, calculated as described above in clause (b), shall be set forth in an Officers’ Certificate of the Company delivered to the Trustee no later than two (2) Business Days prior to the Optional Redemption Date. Notice of
      redemption having been given as provided in the Indenture, the Notes called for redemption shall (subject to the satisfaction or waiver of any applicable condition precedent), on the Optional Redemption Date, become due and payable at the Optional
      Redemption Price, plus accrued and unpaid interest and Additional Amounts, if any, to, but excluding, the Optional Redemption Date.

   

  		Section 1.4	Redemption Upon Changes in Withholding Taxes.


   

  The Notes of either series may be redeemed, as a whole but not in part, at the
      option of the Company, upon not less than 10 nor more than 90 days’ notice (which notice shall be irrevocable), at a redemption price equal to 100% of the principal amount thereof, together with accrued and unpaid interest, if any, to the redemption
      date and Additional Amounts, if any, if as a result of any amendment to, or change in, the laws, regulations, rulings or treaties of the United States or other jurisdiction in which the Company or any successor thereof (including a continuing
      corporation, partnership, limited liability company, joint venture, joint-stock company, association, trust or unincorporated organization formed by a consolidation with the Company, into which the Company is merged, or that acquires or leases all or
      substantially all of the property and assets of the Company) may be organized, as applicable, or any political subdivision thereof or therein having the power to tax (a “Taxing Jurisdiction”), or any change in the application or official
      interpretation of such laws, regulations, rulings or treaties, including any action taken by, or change in the published administrative practice of, a taxing authority or a holding by a court of competent jurisdiction (regardless of whether such
      action, change or holding is with respect to the Company), as a result of such amendment or change, the Company has become, or there is a material probability that it will become, obligated to pay Additional Amounts on the next date on which any
      amount would be payable with respect to the Notes of such series, and such obligation cannot be avoided by the use of commercially reasonable measures available to the Company not including substitution of the obligor on the Notes; provided, however,
      that no such notice of redemption may be given earlier than 90 days prior to the earliest date on which the Company would be obligated, or there is a material probability the Company would otherwise be obligated, to pay such Additional Amount. Prior
      to the publication or, where relevant, mailing (and/or to the extent permitted by applicable procedures or regulations, electronic delivery) of any notice of redemption described in this paragraph, the Company shall deliver to the Trustee (i) an
      Officer’s Certificate of the Company stating that the obligation to pay Additional Amounts cannot be avoided by the Company taking commercially reasonable measures available to it, as described above, and (ii) a written opinion of independent tax
      counsel to the Company of recognized standing to the effect that the Company has or there is a material probability that it will become obligated to pay Additional Amounts as a result of a change, amendment, official interpretation or application
      described above and that the Company cannot avoid the payment of such Additional Amounts by taking commercially reasonable measures available to it as described above.

   

  

  
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  		Section 1.5	Additional Covenants.


   

  The following additional covenants shall apply with respect to the Notes so long as
      any of the Notes remain Outstanding:

   

  		(1)	Change of Control Triggering Event.


   

  (a)          If a Change of Control Triggering Event occurs with respect to either
      series of the Notes, unless the Company shall have redeemed such series of the Notes in full, as set forth in Section 1.3 or 1.4 of this Supplemental Indenture or the Company shall have defeased such series of the Notes or have satisfied and
      discharged such series of the Notes, as set forth in Article XI of the Base Indenture, the Company shall make an offer (a “Change of Control Offer”) to each Holder of the applicable series of the Notes to repurchase any and all of such
      Holder’s Notes of such series at a repurchase price in cash equal to 101% of the aggregate principal amount of the Notes to be repurchased (such principal amount to be equal to €100,000 or any integral multiple of €1,000 in excess thereof), plus
      accrued and unpaid interest, if any, on the Notes to be repurchased up to, but excluding, the date of repurchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, notice shall be delivered to
      the Holders of Notes of such series describing the transaction or transactions that constitute the Change of Control Triggering Event and offering to repurchase such Notes on the date specified in the notice, which date will be no earlier than 10
      days and no later than 60 days from the date such notice is delivered (the “Change of Control Payment Date”). Notwithstanding the foregoing, installments of interest on either series of Notes whose Stated Maturity is on or prior to the Change
      of Control Payment Date shall be payable on the applicable Interest Payment Date to the Holders of such Notes registered as such at the close of business on the applicable regular record date pursuant to the Notes and the Indenture.

   

  

  
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  (b)         On the Change of Control Payment Date, the Company will be required, to
      the extent lawful, to:

   

  		(i)	accept for payment all Notes or portions of Notes of the applicable series properly
            tendered pursuant to the Change of Control Offer;


   

  		(ii)	deposit with the Trustee or a paying agent an amount equal to the Change of Control
            Payment in respect of all Notes or portions of Notes of the applicable series properly tendered; and


   

  		(iii)	deliver or cause to be delivered to the Trustee the Notes properly accepted, together
            with an Officer’s Certificate stating (1) the aggregate principal amount of such series of Notes or portions of such series of Notes being repurchased, (2) that all conditions precedent contained herein to make a Change of Control Offer have
            been complied with and (3) that the Change of Control Offer has been made in compliance with the Indenture.


   

  The Company shall comply in all material respects with the requirements of Rule
      14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the
      extent that the provisions of any such securities laws or regulations conflict with this Section 1.5, the Company shall comply with the applicable securities laws and regulations and shall not be deemed to have breached its obligations under this
      Section 1.5 by virtue of any such conflict.

   

  		(2)	Additional Amounts.


   

  (a)          Unless otherwise required by law, the Company will not deduct or
      withhold from payments made under or with respect to the Notes of either series for or on account of any present or future taxes, duties, levies, imposts, assessments or governmental charges of whatever nature imposed or levied by or on behalf of any
      Taxing Jurisdiction (“Taxes”). In the event that the Company is required to withhold or deduct any amount for or on account of any Taxes from any payment made under or with respect to the Notes of either series, as the case may be, the Company
      will pay such additional amounts (“Additional Amounts”) so that the net amount received by each Holder of the Notes (including Additional Amounts) after such withholding or deduction will equal the amount that such Holder would have received
      if such Taxes had not been required to be withheld or deducted.

   

  

  

  
    11

    
      
 

  

   

  (b)         Additional Amounts will not be payable with respect to a payment made
      to a Holder of the Notes or a Holder of beneficial interests in global securities representing the Notes where such Holder is subject to taxation on such payment by a relevant Taxing Jurisdiction for any reason other than such Holder’s mere ownership
      of the Notes or for or on account of:

   

  		(i)	any Taxes that are imposed or withheld solely because such Holder (or the beneficial
            owner for whose benefit such Holder holds the Notes) or a fiduciary, settlor, beneficiary, member, shareholder or other equity owner of, or possessor of a power over, such Holder (or beneficial owner) if such Holder (or beneficial owner) is an
            estate, trust, partnership, limited liability company, corporation or other entity:


   

  		(A)	is or was present or engaged in, or is or was treated as present or engaged in, a
            trade or business in the Taxing Jurisdiction or has or had a permanent establishment in the Taxing Jurisdiction (in each cash, other than the mere fact of ownership of such securities, without another presence or business in such Taxing
            Jurisdiction);


   

  		(B)	has or had any present or former connection (other than the mere fact of ownership
            of the Notes) with the Taxing Jurisdiction imposing such Taxes, including being or having been a national citizen or resident thereof, being treated as being or having been a resident thereof or being or having been physically present therein;


   

  		(C)	with respect to any withholding Taxes imposed by the United States, is or was with
            respect to the United States a personal holding company, a passive foreign investment company, a controlled foreign corporation, a foreign private foundation or other foreign tax exempt organization or corporation that has accumulated earnings
            to avoid United States federal income tax;


   

  		(D)	actually or constructively owns or owned 10% or more of the total combined voting
            power of all of the Company’s classes of stock within the meaning of Section 871(h)(3) of the Code; or


   

  		(E)	is or was a bank receiving payments on an extension of credit made pursuant to a
            loan agreement entered into in the ordinary course of its trade or business within the meaning of Section 881(c)(3) of the Code;


   

  		(ii)	any estate, inheritance, gift, sales, transfer, excise, personal property or similar
            Taxes imposed with respect to the Notes, except as otherwise provided herein;


   

  		(iii)	any Taxes imposed solely as a result of the presentation of the Notes (where
            presentation is required) for payment on a date more than 15 days after the date on which such payment became due and payable or the date on which payment thereof is duly provided for, whichever is later, except to the extent that the
            beneficiary or Holder thereof would have been entitled to the payment of Additional Amounts had the Notes been presented for payment on any date during such 15-day period;


   

  

  
    12

    
      
 

  

   

  		(iv)	any Taxes imposed or withheld solely as a result of the failure of such Holder or
            any other person to comply with applicable certification, information, documentation or other reporting requirements concerning the nationality, residence, identity or connection with the Taxing Jurisdiction of such Holder, if such compliance
            is required by statute, regulation, ruling or administrative practice of the relevant Taxing Jurisdiction or by any applicable tax treaty to which the relevant Taxing Jurisdiction is a party as a precondition to relief or exemption from such
            Taxes;


   

  		(v)	with respect to withholding Taxes imposed by the United States, any such Taxes
            imposed by reason of the failure of such Holder to fulfill the statement requirements of sections 871(h) or 881(c) of the Code;


   

  		(vi)	any Taxes that are payable by any method other than withholding or deduction by the
            Company or any paying agent from payments in respect of the Notes;


   

  		(vii)	any Taxes required to be withheld by any paying agent from any payment in respect
            of the Notes if such payment can be made without such withholding by at least one other paying agent;


   

  		(viii)	any withholding or deduction for Taxes which would not have been imposed if the
            Notes had been presented to another paying agent in a country that is a member state of the European Union as of the date hereof;


   

  		(ix)	any withholding or deduction required pursuant to sections 1471 through 1474 of the
            Code, any regulations or agreements thereunder, official interpretations thereof, any intergovernmental agreement, or any law, rule, guidance or administrative practice implementing an intergovernmental agreement entered into in connection with
            such sections of the Code; or


   

  		(x)	any combination of items (i), (ii), (iii), (iv), (v), (vi), (vii), (viii) and (ix) above;


   

  Additional Amounts also will not be payable to any Holder of the Notes or the Holder of a beneficial
      interest in a global security representing the Notes that is a fiduciary, partnership, limited liability company or other fiscally transparent entity, or to such Holder that is not the sole Holder of such security or Holder of such beneficial
      interests in such security, as the case may be. The exception, however, will apply only to the extent that a beneficiary or settlor with respect to the fiduciary, or a beneficial owner or member of the partnership, limited liability company or other
      fiscally transparent entity, would not have been entitled to the payment of an Additional Amount had the beneficiary, settlor, beneficial owner or member received directly its beneficial or distributive share of the payment.

   

  (c)          The Company will also (i) make such withholding or deduction of Taxes
      and (ii) remit the full amount of Taxes so deducted or withheld to the relevant Taxing Jurisdiction in accordance with all applicable laws. The Company will use its commercially reasonable efforts to obtain from each Taxing Jurisdiction imposing such
      Taxes certified copies of tax receipts evidencing the payment of any Taxes deducted or withheld. The Company will, upon request, make available to the Holders of the Notes, within 90 days after the date the payment of any Taxes so deducted or
      withheld is due pursuant to applicable law, certified copies of tax receipts evidencing such payment by the Company or if, notwithstanding the Company’s efforts to obtain such receipts, the same are not obtainable, other evidence of such payments.

   

  

  
    13

    
      
 

  

   

  (d)         At least 30 days prior to each date on which any payment under or with
      respect to the Notes of either series is due and payable for which the Company will be obligated to pay Additional Amounts, with respect to such payment, the Company will deliver to the Trustee an Officers’ Certificate stating the fact that such
      Additional Amounts will be payable, the amounts so payable and such other information as is necessary to enable the Trustee to pay such Additional Amounts to Holders of such series of Notes on the payment date.

   

  (e)          In addition, the Company will pay any stamp, issue, registration,
      documentary or other similar taxes and duties, including interest, penalties and Additional Amounts with respect thereto, payable in the United States or any political subdivision or taxing authority of or in the United States in respect of the
      creation, issue, offering, enforcement, redemption or retirement of the Notes of either series.

   

  (f)          The provisions of this Section 1.5(2) shall survive any termination or
      the discharge of this Supplemental Indenture and shall apply mutatis mutandis to any jurisdiction in which the Company or any successor Person to the Company is organized or is engaged in business for tax purposes or any political subdivisions or
      taxing authority or agency thereof or therein; provided, however, the date on which the Company changes its jurisdiction in which it is organized or such Person becomes a successor to the Company shall be substituted for the date on which the
      applicable series of Notes was issued.

   

  (g)         Whenever in this Supplemental Indenture or the Notes there is
      mentioned, in any context, the payment of principal and premium, if any, redemption price, interest or any other amount payable under or with respect to any Note, such mention shall be deemed to include mention of the payment of Additional Amounts to
      the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof.

   

  		Section 1.6	Events of Default.


   

  (a)         The provisions of Article VI of the Base Indenture shall be applicable
      to each series of the Notes, except that clauses (1) through (7) of Section 6.01(a) thereof shall be modified with respect to Notes of a series as follows:

   

  (1)          default in the payment of the principal or any premium on such series
      of Notes when due (whether at maturity, upon acceleration, redemption or otherwise);

   

  (2)         default for 30 days in the payment of
      interest on the Notes of such series when due;

   

  (3)         (i) failure by the Company to comply with
      Section 1.5(1) of this Supplemental Indenture with respect to such series of Notes or (ii) failure by the Company to observe or perform any term of the Indenture applicable to such series of Notes (other than those referred to in (1) or (2) above or
      (3)(i) above) for a period of 90 days after the Company receives a notice of default stating that the Company is in breach. The notice required under 3(ii) above must be sent by either the Trustee or Holders of 25% of the principal amount of the
      applicable series of Notes;

   

  

  
    14

    
      
 

  

   

  (4)          (A) failure by the Company to pay indebtedness for money borrowed by
      the Company or for which the Company has guaranteed the payment, in an aggregate principal amount of at least $500,000,000, at the later of final maturity and the expiration of any related applicable grace period and such defaulted payment shall not
      have been made, waived or extended within 30 days or (B) acceleration of the maturity of any indebtedness for money borrowed by the Company or for which the Company has guaranteed the payment, in an aggregate principal amount of at least
      $500,000,000, if such indebtedness has not been discharged in full or such acceleration has not been rescinded or annulled within 30 days; provided, however, that, if the default under the instrument is cured by the Company, or waived
      by the holders of the indebtedness, in each case as permitted by the governing instrument, then the Event of Default under the Indenture caused by such default will be deemed likewise to be cured or waived;

   

  (5)          the entry by a court having competent
      jurisdiction of:

   

  (A)         an order for relief in respect of the
      Company as debtor in an involuntary proceeding under any applicable Bankruptcy Law and such order shall remain unstayed and in effect for a period of 60 consecutive days; or

   

  (B)         a final and non-appealable order appointing a Custodian of
      the Company, or ordering the winding up or liquidation of the affairs of the Company, and such order shall remain unstayed and in effect for a period of 60 consecutive days; or

   

  (6)         the commencement by the Company of a voluntary proceeding under any
      applicable Bankruptcy Law or the consent by the Company as debtor to the entry of a decree or order for relief in an involuntary proceeding under any applicable Bankruptcy Law, or the filing by the Company as debtor of a consent to an order for
      relief in any involuntary proceeding under any Bankruptcy Law, or to the appointment of a Custodian or the making by the Company of an assignment for the benefit of creditors.

   

  ARTICLE II

   

  MISCELLANEOUS

   

  		Section 2.1	Business Day.


   

  If any maturity date or earlier date of redemption for either series of Notes falls
      on a day that is not a Business Day, the required payment shall be made on the next Business Day as if it were made on the date the payment to Holders was due and no interest shall accrue on the amount so payable for the period from and after that
      maturity date or that date of redemption, as the case may be.

   

  		Section 2.2	[Reserved].


   

  

  
    15

    
      
 

  

   

  		Section 2.3	Confirmation of Indenture.


   

  The Base Indenture, as supplemented and amended by this Supplemental Indenture, is
      in all respects ratified and confirmed, and the Base Indenture, this Supplemental Indenture and all indentures supplemental thereto shall be read, taken and construed as one and the same instrument.

   

  		Section 2.4	Concerning the Trustee.


   

  In carrying out its responsibilities hereunder, the Trustee shall have all of the
      rights, protections and immunities which it possesses under the Indenture. The recitals contained herein and in the Notes, except the Trustee’s certificate of authentication, shall be taken as the statements of the Company, and the Trustee assumes no
      responsibility for their correctness. The Trustee makes no representations as to the validity or sufficiency of this Supplemental Indenture or of the Notes. The Trustee shall not be accountable for the use or application by the Company of the Notes
      or the proceeds thereof.

   

  		Section 2.5	Governing Law.


   

  This Supplemental Indenture and the Notes shall be deemed to be a contract made
      under the internal laws of the State of New York, and for all purposes shall be governed by and construed in accordance with the laws of said State.

   

  		Section 2.6	Separability.


   

  In case any provision in this Supplemental Indenture shall for any reason be held
      to be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby.

   

  		Section 2.7	Counterparts.


   

  This Supplemental Indenture may be executed in any number of counterparts each of
      which shall be an original, but such counterparts shall together constitute but one and the same instrument. The exchange of copies of this Supplemental Indenture and of signature pages by facsimile or electronic format (e.g., “.pdf” or “.tif”)
      transmission shall constitute effective execution and delivery of this Supplemental Indenture as to the parties hereto and may be used in lieu of the original Supplemental Indenture for all purposes.

   

  The words “execution,” “signed,” “signature,” and words of like import in this
      Supplemental Indenture, the Indenture or any agreement entered into in connection herewith shall be deemed to include electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or
      enforceability as a manually executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National Commerce
      Act, the New York State Electronic Signatures and Records Act, or any other similar state laws based on the Uniform Electronic Transactions Act (e.g. DocuSign). Without limitation to the foregoing, and anything in the Indenture to the contrary
      notwithstanding, (a) any Officer’s Certificate, Authentication Order, Opinion of Counsel, Security, certificate of authentication appearing on or attached to any Security, or other certificate, opinion of counsel, instrument, agreement or other
      document delivered pursuant to the Indenture may be executed, attested and transmitted by any of the foregoing electronic means and formats and (b) all references in Section 2.04 or elsewhere in the Base Indenture to the execution, attestation or
      authentication of any Security or any certificate of authentication appearing on or attached to any Security by means of a manual or facsimile signature shall be deemed to include signatures that are made or transmitted by any of the foregoing
      electronic means or formats.

   

  

  
    16

    
      
 

  

   

  		Section 2.8	No Benefit.


   

  Nothing in this Supplemental Indenture, express or implied, shall give to any
      Person other than the parties hereto and their successors or assigns, and the Holders, any benefit or legal or equitable rights, remedy or claim under this Supplemental Indenture or the Base Indenture.

   

  		Section 2.9	Electronic Means.


   

  The Trustee shall have the right to accept and act upon instructions, including
      funds transfer instructions (“Instructions”) given pursuant to the Indenture and delivered using Electronic Means; provided, however, that the Company shall provide to the Trustee an incumbency certificate listing officers with the authority
      to provide such Instructions (“Authorized Officers”) and containing specimen signatures of such Authorized Officers, which incumbency certificate shall be amended by the Company whenever a person is to be added or deleted from the listing. If
      the Company elects to give the Trustee Instructions using Electronic Means and the Trustee in its discretion elects to act upon such Instructions, the Trustee’s understanding of such Instructions shall be deemed controlling. The Company understands
      and agrees that the Trustee cannot determine the identity of the actual sender of such Instructions and that the Trustee shall conclusively presume that directions that purport to have been sent by an Authorized Officer listed on the incumbency
      certificate provided to the Trustee have been sent by such Authorized Officer. The Company shall be responsible for ensuring that only Authorized Officers transmit such Instructions to the Trustee and that the Company and all Authorized Officers are
      solely responsible to safeguard the use and confidentiality of applicable user and authorization codes, passwords and/or authentication keys upon receipt by the Company. The Trustee shall not be liable for any losses, costs or expenses arising
      directly or indirectly from the Trustee’s reliance upon and compliance with such Instructions notwithstanding such directions conflict or are inconsistent with a subsequent written instruction. The Company agrees: (i) to assume all risks arising out
      of the use of Electronic Means to submit Instructions to the Trustee, including without limitation the risk of the Trustee acting on unauthorized Instructions, and the risk of interception and misuse by third parties; (ii) that it is fully informed
      of the protections and risks associated with the various methods of transmitting Instructions to the Trustee and that there may be more secure methods of transmitting Instructions than the method(s) selected by the Issuer; (iii) that the security
      procedures (if any) to be followed in connection with its transmission of Instructions provide to it a commercially reasonable degree of protection in light of its particular needs and circumstances; and (iv) to notify the Trustee immediately upon
      learning of any compromise or unauthorized use of the security procedures.

   

  		Section 2.10	OFAC Certification and Covenants.


   

  (a)         The Company covenants and represents that neither it nor any of its
      subsidiaries, directors or officers are the target or subject of any sanctions enforced by the US Government, (including, the Office of Foreign Assets Control of the US Department of the Treasury (“OFAC”)), the United Nations Security Council,
      the European Union, or Her Majesty’s Treasury (collectively “Sanctions”).

   

  

  
    17

    
      
 

  

   

  (b)         The Company covenants and represents that neither it nor any of its
      subsidiaries, directors or officers will use any part of the proceeds received in connection with the Indenture and the Notes to be issued thereunder or any other of the transaction documents to fund or facilitate any activities of or business with
      any person who, at the time of such funding or facilitation, to the Company’s knowledge after due inquiry, is the subject or target of Sanctions.

   

  [SIGNATURE PAGES FOLLOW]

   

  
    18

    
      
 

  

  IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to
      be duly executed all as of the day and year first above written.

   

  

  	 	THERMO FISHER SCIENTIFIC INC.
	 	 
	 	By:	/s/ Anthony H. Smith	 
	 	 	Name:	Anthony H. Smith	 
	 	 	Title:	Vice President, Tax and Treasury and Treasurer	 


   

  

  [Twenty-Fifth Supplemental Indenture]

   

  
    

    
      
 

  

   

  

  	 	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
	 	 
	 	By:	/s/ April Bradley	 
	 	 	Name:	April Bradley	 
	 	 	Title:	Vice President	 


  

   

  [Twenty-Fifth Supplemental Indenture]

   

  
    

    
      
 

  

  
   

  EXHIBIT A

   

  [Insert the Global Security legend, if applicable]

   

  [  ]%1 SENIOR NOTES DUE [  ]2

   

  	No. [  ]	€ [  ]


  

  ISIN No. [  ]3

   

  THERMO FISHER SCIENTIFIC INC.

   

  promises to pay to [ ] or registered assigns, the principal sum of [ ] Euro on [ ]4.

   

  Interest Payment Date: [ ]5

   

  Record Date: The Business Day immediately preceding the applicable Interest Payment Date

   

  Each holder of this Security (as defined below), by accepting the same, agrees to
      and shall be bound by the provisions hereof and of the Indenture described herein, and authorizes and directs the Trustee described herein on such holder’s behalf to be bound by such provisions. Each holder of this Security hereby waives all notice
      of the acceptance of the provisions contained herein and in the Indenture and waives reliance by such holder upon said provisions.

   

  This Security shall not be entitled to any benefit under the Indenture, or be valid
      or become obligatory for any purpose, until the Certificate of Authentication hereon shall have been signed by or on behalf of the Trustee. The provisions of this Security are continued on the reverse side hereof, and such continued provisions shall
      for all purposes have the same effect as though fully set forth at this place.

   

  

  
  
     

  

  
  

  1 2026 Notes: 3.200%
      and 2034 Notes: 3.650%

  

  2 2026 Notes: 2026
      and 2034 Notes: 2034

  

  3 2026 Notes:
      XS2557526006 and 2034 Notes: XS2557526345

  

  4 2026 Notes: January
      21, 2026 and 2034 Notes: November 21, 2034

  

  5 2026 Notes: January
      21 and 2034 Notes: November 21

   

  
    A-1

    
      
 

  

   

  IN WITNESS WHEREOF, the Company has caused this instrument to be signed in
      accordance with Section 2.04 of the Base Indenture.

   

  Date: [             ]

   

  

  	 	THERMO FISHER SCIENTIFIC INC.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:


   

  
    A-2

    
      
 

  

   

  CERTIFICATE OF AUTHENTICATION

   

  This is one of the [      ]6
      issued by Thermo Fisher Scientific Inc. of the series designated therein, referred to in the within-mentioned Indenture.

   

  Date: [            ]

   

  

  	 	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.
	 	as Trustee	 
	 	 	 
	 	By:	 	 
	 	 	Authorized Signatory	 


   

  
  
     

  

  
  

  6 2026 Notes: 3.200%
      Senior Notes due 2026 and 2034 Notes: 3.650% Senior Notes due 2034

   

  
    A-3

    
      
 

  

   

  Thermo Fisher Scientific Inc.

   

  [ ]7

   

  This security is one of a duly authorized series of debt securities of Thermo Fisher Scientific Inc., a
      Delaware corporation (the “Company”), issued or to be issued in one or more series under and pursuant to an Indenture for the Company’s unsubordinated debt securities, dated as of November 20, 2009 (the “Base Indenture”), duly executed
      and delivered by and among the Company and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”), as supplemented by the Twenty-Fifth Supplemental Indenture, dated as of November 21, 2022 (the “Supplemental Indenture”),

      between the Company and the Trustee. The Notes are subject to a Paying Agency Agreement, dated as of November 21, 2022 (the “Paying Agency Agreement”), between the Company and The Bank of New York Mellon, London Branch, as paying agent (the “Paying

        Agent”). The Base Indenture as supplemented and amended by the Supplemental Indenture is referred to herein as the “Indenture.” By the terms of the Base Indenture, the debt securities issuable thereunder are issuable in series that may
      vary as to amount, date of maturity, rate of interest and in other respects as provided in the Base Indenture. This security is one of the series designated on the face hereof (individually, a “Security,” and collectively, the “Securities”),


      and reference is hereby made to the Indenture for a description of the rights, limitations of rights, obligations, duties and immunities of the Trustee, the Company and the holders of the Securities (the “Securityholders”). Capitalized terms
      used herein and not otherwise defined shall have the meanings given them in the Base Indenture or the Supplemental Indenture, as applicable.

   

  1.            Interest. The Company promises to pay interest on the
      principal amount of this Security at an annual rate of [ ]%8. The Company will pay interest annually in arrears on [ ]9 of each year (each such day, an “Interest Payment Date”) until the principal is paid or made available for payment. If any Interest Payment Date, redemption date or maturity date of this Security is not a
      Business Day, then payment of interest or principal (and premium, if any) shall be made on the next succeeding Business Day with the same force and effect as if made on the date such payment was due, and no interest shall accrue for the period after
      such date to the date of such payment on the next succeeding Business Day. Interest on the Securities will accrue from the most recent date to which interest has been paid or duly made available for payment or, if no interest has been paid, from the
      date of issuance; provided that, if there is no existing Default in the payment of interest, and if this Security is authenticated between a regular record date referred to on the face hereof and the next succeeding Interest Payment Date,
      interest shall accrue from such next succeeding Interest Payment Date; and provided, further, that the first Interest Payment Date shall be [ ].10 Interest on
      the Securities shall be computed on the basis of an ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of ICMA) day count convention. In order to provide for all payments due on the Securities as the same shall become due, the Company shall cause to be
      paid to the Paying Agent, no later than 10:00 a.m. London time on the Business Day prior the payment date of each Security, at such bank as the Paying Agent shall previously have notified to the Company, in immediately available funds sufficient to
      meet all payments due on such Securities.

   

  
  
     

  

  
  

  7 2026 Notes: 3.200%
      Senior Notes due 2026 and 2034 Notes: 3.650% Senior Notes due 2034

  

  8 2026 Notes: 3.200%
      and 2034 Notes: 3.650%

  

  9 2026 Notes: January
      21 and 2034 Notes: November 21

  

  10 2026 Notes:
      January 21, 2023 and 2034 Notes: November 21, 2023

   

  
    A-4

    
      
 

  

  

   

  2.           Method of Payment. The Company will pay interest on the
      Securities (except defaulted interest), if any, to the persons in whose name such Securities are registered at the close of business on the regular record date referred to on the facing page of this Security for such interest installment. In the
      event that the Securities or a portion thereof are called for redemption pursuant to an optional redemption or there is a Change of Control Offer, and the Optional Redemption Date or Change of Control Payment Date, as applicable, is subsequent to a
      regular record date with respect to any Interest Payment Date and prior to such Interest Payment Date, interest on such Securities shall instead be paid upon presentation and surrender of such Securities as provided in the Indenture. Subject to
      Section 1.2 of the Supplemental Indenture, all payments of principal of, and interest (including Additional Amounts, if any) and premium (if any) on, the Securities shall be payable in euro.

   

  3.           Paying Agent and Registrar. Initially, The Bank of New York
      Mellon, London Branch, shall act as the Paying Agent in accordance with the terms of the Paying Agency Agreement and the Trustee shall act as Security Registrar. Upon prior notice to the Trustee, the Company may change or appoint any Paying Agent or
      Security Registrar without notice to any Securityholder. The Company or any of its Subsidiaries may act in any such capacity.

   

  4.           Indenture. The terms of the Securities include those stated in
      the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended (“TIA”), as in effect on the date the Indenture is qualified. The Securities are subject to all such terms, and Securityholders are
      referred to the Indenture and TIA for a statement of such terms. In the event of a conflict between the terms of the Securities and the terms of the Indenture, the terms of the Indenture shall prevail. The Securities are unsecured general obligations
      of the Company and constitute the series designated on the face hereof as the “[ ]11,” initially limited to €[ ]12 in aggregate principal amount. The Company shall furnish to any Securityholder upon written request and without charge a copy of the Base Indenture and the Supplemental Indenture. Requests may be made to: Thermo Fisher
      Scientific Inc., 168 Third Avenue, Waltham, Massachusetts 02451, Attention: Michael A. Boxer.

   

  5.           Redemption. The Securities may be redeemed at the option of
      the Company prior to the maturity date, as provided in Section 1.3 and 1.4 of the Supplemental Indenture. The Company shall not be required to make sinking fund payments with respect to the Securities.

   

  6.           Redemption Upon Changes in Withholding Taxes; Payment of
        Additional Amounts.

   

  

  
  
     

  

  
  

  11 2026 Notes: 3.200%
      Senior Notes due 2026 and 2034 Notes: 3.650% Senior Notes due 2034

  

  12 2026 Notes:
      €500,000,000 and 2034 Notes: €750,000,000

   

  
    A-5

    
      
 

  

   

  The provisions of Sections 1.4 and 1.5(2) of the Supplemental Indenture shall apply
      to the Securities.

   

  Whenever the payment of the principal of or interest or any other amounts on, or in
      respect of, the Securities is mentioned, in any context, such mention shall be deemed to include mention of the payment of Additional Amounts to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof
      pursuant to the terms of the Indenture, and express mention of the payment of Additional Amounts in any provision of the Securities shall not be construed as excluding the payment of Additional Amounts in those provisions where such express mention
      is not made.

   

  7.            Change of Control Triggering Event. Upon the occurrence of a
      Change of Control Triggering Event, unless the Company has redeemed this Security or the Company has defeased this Security or satisfied and discharged this Security, the holder of this Security shall have the right to require that the Company
      repurchase all or a portion (such principal amount to be equal to €100,000 or any integral multiple of €1,000 in excess thereof) of this Security at a repurchase price equal to 101% of the aggregate principal amount repurchased plus accrued and
      unpaid interest, if any, on the amount to be repurchased up to but excluding the date of repurchase. Within 30 days following any Change of Control Triggering Event, the Company shall send, by first class mail, a notice to each Holder, in accordance
      with Section 1.5(1)(a) of the Supplemental Indenture, with a copy to the Trustee, which notice shall govern the terms of the Change of Control Offer.

   

  8.            Denominations, Transfer, Exchange. The Securities are in
      registered form without coupons in the denominations of €100,000 or any integral multiple of €1,000 in excess thereof. The transfer of Securities may be registered and Securities may be exchanged as provided in the Indenture. The Securities may be
      presented for exchange or for registration of transfer (duly endorsed or with the form of transfer endorsed thereon duly executed if so required by the Company or the Security Registrar) at the office of the Paying Agent or at the office of any
      transfer agent designated by the Company for such purpose. No service charge shall be made for any registration of transfer or exchange, but a Securityholder may be required to pay any applicable taxes or other governmental charges. If the Securities
      are to be redeemed, the Company shall not be required to: (i) issue, register the transfer of, or exchange any Security during a period beginning at the opening of business 15 days before the day of mailing of a notice of redemption of less than all
      of the outstanding Securities and ending at the close of business on the day of such mailing; (ii) register the transfer of or exchange any Security or portions thereof selected for redemption, in whole or in part, except the unredeemed portions of
      any such Security being redeemed in part; nor (iii) register the transfer of or exchange of a Security between the applicable record date and the next succeeding Interest Payment Date.

   

  9.           Persons Deemed Owners. The registered Securityholder may be
      treated as its owner for all purposes.

   

  10.         Repayment to the Company. Any funds or Governmental Obligations
      deposited with any paying agent or the Trustee, or then held by the Company, in trust for payment of principal of, premium, if any, or interest on the Securities that are not applied but remain unclaimed by the holders of such Securities for at least
      one year after the date upon which the principal of, premium, if any, or interest on such Securities shall have respectively become due and payable, shall be repaid to the Company, as applicable, or (if then held by the Company) shall be discharged
      from such trust. After return to the Company, Holders entitled to the money or securities must look to the Company, as applicable, for payment as unsecured general creditors.

   

  
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  11.         Amendments, Supplements and Waivers. The Indenture permits,
      with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities to be affected under the Indenture at any time by the Company and the
      Trustee with the consent of the Holders of a majority in principal amount of the Securities at the time Outstanding to be affected. The Indenture also contains provisions permitting the Holders of a majority in principal amount of the Securities at
      the time Outstanding, on behalf of the Holders of all Securities, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the
      Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
      notation of such consent or waiver is made upon this Security.

   

  12.         Defaults and Remedies. If an Event of Default with respect to
      the Securities occurs and is continuing, the Trustee or the holders of at least 25% in aggregate principal amount of the Securities then Outstanding, by notice in writing to the Company (and to the Trustee if notice is given by such holders), may
      declare the entire principal amount of, premium, if any, and accrued interest, if any, of such Securities due and immediately payable. Subject to the terms of the Indenture, if an Event of Default under the Indenture shall occur and be continuing,
      the Trustee shall be under no obligation to exercise any of its rights or powers under the Indenture at the request or direction of any of the holders, unless such holders have offered the Trustee indemnity satisfactory to it. Upon satisfaction of
      certain conditions set forth in the Indenture, the holders of a majority in principal amount of the Outstanding Securities shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee,
      or exercising any trust or power conferred on the Trustee, with respect to the Securities.

   

  13.         Trustee, Paying Agent and Security Registrar May Hold Securities.
      The Trustee, subject to certain limitations imposed by the TIA, or any paying agent or Security Registrar, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were not
      Trustee, paying agent or Security Registrar.

   

  14.         No Recourse Against Others. No recourse under or upon any
      obligation, covenant or agreement of the Indenture, or of any Security, or for any claim based thereon or otherwise in respect hereof or thereof, shall be had against any incorporator, stockholder, officer or director, past, present or future as
      such, of the Company or of any predecessor or successor corporation, either directly or through the Company or any such predecessor or successor corporation, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any
      assessment or penalty or otherwise; it being expressly understood that the Indenture and the obligations issued hereunder and thereunder are solely corporate obligations, and that no such personal liability whatever shall attach to, or is or shall be
      incurred by, the incorporators, stockholders, officers or directors as such, of the Company or of any predecessor or successor corporation, or any of them, because of the creation of the indebtedness authorized by the Indenture, or under or by reason
      of the obligations, covenants or agreements contained in the Indenture or in the Securities or implied therefrom; and that any and all such personal liability of every name and nature, either at common law or in equity or by constitution or statute,
      of, and any and all such rights and claims against, every such incorporator, stockholder, officer or director as such, because of the creation of the indebtedness authorized by the Indenture, or under or by reason of the obligations, covenants or
      agreements contained in the Indenture or in the Securities or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration for, the acceptance of the Securities.

   

  
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  15.         Discharge of Indenture. The Indenture
      contains certain provisions pertaining to discharge and defeasance, which provisions shall for all purposes have the same effect as if set forth herein.

   

  16.         Authentication. This Security shall not be valid until the
      Trustee signs the certificate of authentication attached to the other side of this Security.

   

  17.         Abbreviations. Customary abbreviations may be used in the name
      of a Securityholder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (=tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (=Custodian), and U/G/M/A (= Uniform Gifts to
      Minors Act).

   

  18.         Governing Law. The Base Indenture, the Supplemental Indenture
      and this Security shall be deemed to be a contract made under the internal laws of the State of New York, and for all purposes shall be construed in accordance with the laws of said State.

   

  
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  ASSIGNMENT FORM

   

  To assign this Security, fill in the form below: (I) or (we) assign and transfer
      this Security to

  

  	 
	 
	(Insert assignee’s soc. sec. or tax I.D. no.)
	 
	 
	 
	 


  

  (Print or type assignee’s name, address and zip code)

   

  and irrevocably appoint
      __________________________________________________________ agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

   

  Date: ______________

  

  	 	 	 
	 	Your Signature	 
	 	(Sign exactly as your name appears on the face of this Security)


   

  Signature Guarantee: ______________________________

   

  
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  OPTION OF HOLDER TO ELECT PURCHASE

   

  If you want to elect to have this Security purchased by the Company pursuant to
      Section 1.5(l) of the Supplemental Indenture, check the box:

   

  		☐	1.5(l) Change of Control Triggering Event


   

  If you want to elect to have only part of this Security purchased by the Company
      pursuant to Section 1.5(l) of the Supplemental Indenture, state the amount: €_________

   

  

  	Date: ________________________	 	 
	 	 	 
	 	Your Signature	 
	 	(Sign exactly as your name appears on the face of this Security)


  

   

  	 	Tax I.D. Number:_______________________


   

  

  	Signature Guarantee:	 	 
	 	(Signature must be guaranteed by a participant in a recognized signature guarantee medallion program)	 


  

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