Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

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PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (26-

October-2011; DP#389652).

II. Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock: 

Residues of concern were determined based on recommendations from the HED Residues of 

Concern Knowledgebase Sub-committee (ROCKS) (D391350, 9/19/11). The residue of concern 

for plant commodities for tolerance expression and risk assessment purposes is difenoconazole 

per se. The HED ROCKS has determined that the parent compound and the CGA-205375 

metabolite are the residues of concern in livestock commodities for both the tolerance expression 

and the risk assessment. In addition, metabolite OH-CGA-169374, which comprised 15% of the 

TRR in goat milk from the phenyl-labeled study, should be considered as a residue of concern for 

the dietary risk assessment. Based on available goat metabolism data, total residues of concern 

in milk for dietary risk assessments (parent, CGA-205375, and OH-CGA-169374), should be 

calculated by multiplying the tolerance in milk by a factor of 1.5x. Table 1 summarizes tolerance 

expression and the residues of concern in plant and livestock commodities.

Table 1. Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants Primary and Rotational crops Parent Only Parent Only

Livestock Ruminant and Poultry Parent and CGA 205375 Parent and CGA 205375

Milk Parent, CGA 205375 and 

OH-CGA-169374

Parent and CGA 205375

Drinking Water Parent Only NA

Note: The triazole-containing metabolites 1,2,4-T, TA, and TAA should be included in the residues of concern for risk 

assessment purposes only for plant and livestock commodities. Since these metabolites are common to the entire class of 

traizole-derivative fungicides and because of differential toxicity between metabolites and the various parent compounds, risks 

associated with exposure to 1,2,4-T and to TA/TAA are addressed separately.

Recommended Tolerances: Based on the residue chemistry data submitted with the previous

petitions, HED recommended for establishment of the new food tolerances (DP# 366507, B. 

Cropp-Kohlligian, 30-May-2012). The recommended, established, and revised tolerances are 

listed in Table 2 below.
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Table 2. Tolerance Summary for Difenoconazole (non feed items).

Commodity Existing/Established 

Tolerances (ppm)

New Tolerances (ppm)

Almond, nutmeat 0.03 ------

Brassica subgroup 5A 1.9 ------

Brassica subgroup 5B 35 ------

Citrus oil 25 ------

Fruit, citrus, group 10 0.6 ------

Grape 4.0 ------

Grape, raisin 6.0 ------

Nut, tree, group 14 0.03 ------

Onion, bulb, subgroup 3—07A 0.20 ------

Onion, green, subgroup 3—07B 6.0 ------

Pistachios 0.03 ------

Vegetable, cucurbit, group 9 0.7 ------

Fruit, Pome, group 11 1.0 ------

Vegetable, Fruiting, Group 8 0.60 ------

Vegetable, Tuberous and Corm, 

subgroup 1C

0.01 4.0

Beet, sugar 0.30 ------

Papaya 0.30 ------

Banana 0.2 ------

Barley, grain 0.1 ------

Canola, seed 0.01 ------

Cattle fat 0.10 ------

Cattle, meat 0.05 ------

Cattle, meat byproducts 0.10 ------

Cattle, liver 0.40 ------

Corn, sweet, kernel plus cob 

with husks removed

0.01 ------

Cotton, undelinted seed 0.05 ------

Egg 0.02 ------

Goat, fat 0.10 ------

Goat, meat 0.05 ------

Goat, meat byproducts (except 

liver)

0.10 ------

Goat, liver 0.40 ------

Hog, fat 0.10 ------

Hog, meat 0.05 ------

Hog, meat byproducts (except 

liver)

0.1 ------

Hog, liver 0.40 ------

Horse, fat 0.10 ------

Horse, meat 0.05 ------

Horse, meat byproducts (except 0.10 ------
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Table 2. Tolerance Summary for Difenoconazole (non feed items).

Commodity Existing/Established 

Tolerances (ppm)

New Tolerances (ppm)

liver)

Horse, liver 0.40 ------

Milk 0.01 ------

Rye, grain 0.01 ------

Sheep, fat 0.10 ------

Sheep, meat 0.05 ------

Sheep, meat byproducts (except 

liver)

0.10 ------

Sheep, liver 0.40 ------

Wheat, grain 0.1 ------

Wax apple 0.07 ------

Mango 0.07 ------

Carrot 0.50 ------

Chickpea 0.08 ------

Soybean, seed 0.15 ------

Fruit, stone, group 12 2.5 ------

Strawberry 2.5 ------

Turnip greens 35 ------

Oat, grain 0.01 ------

The dietary exposure analyses for the triazole metabolites (D397591, T. Morton, 19 Jan. 

2012) was updated.

Food Residues and processing factors used in the Acute and Chronic Analysis: The acute 

analysis assumed tolerance-level residues and 100% CT for all the registered and proposed crops.

Tolerance-level residues were also assumed for all livestock tissues in this assessment. The 

chronic analysis assumed tolerance-level residues for some commodities, average field trial 

residues for the majority of commodities, and 100 % CT. Those commodities where field trial 

data were used are summarized below. HED SOP 2000.1 Guidance for Translation of Field 

Trial Data from Representative Commodities in the Crop Group Regulation to Other 

Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other 

commodities in the crop group. Experimental processing factors were used for apple juice 

(0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), 

raisin (3.5x chronic only since the raisin tolerance was used in acute), sugar beet molasses (0.6x), 

tomato paste (1.6x), and tomato puree (0.5x); DEEM (ver. 7.81) default processing factors 

were assumed for other processed commodities. 

Almond: Field trial residues were used from MRID 47586101. 

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102. Residues from 1-7 day PHI were 

used since registered labels allow from 1-7 day PHIs.
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Cabbage: Field trial residues were used from 47586102. Residues from 1-7 day PHI were used 

since registered labels allow from 1-7 day PHIs. To refine the dietary exposure data from only 

cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI 

were used since registered labels allow from 0-1 day PHI.

Carrot: Field trial residues were used from MRID 47929804.

Chickpea: Field trial residues were used from MRID 47929805.

Cucumber: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI 

were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 

47586102. Residues from 1-7 day PHI were used since registered labels allow from 1-7 day 

PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 47929804.

Soybean: Field trial residues were used from MRID 47929801.

Stone Fruit: Field trial residues were used from MRID 47929803.

Strawberry: Field trial residues were used from MRID 47929802.

Sugar Beet: Field trial residues were used from MRID 46950236.
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Summer Squash: Field trial residues were used from MRID 47586103. Residues from 0-1 day 

PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

III. Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED; Memo, F. Khan, 23-February-2012; D398836). 

EFED conducted a Tier II drinking water assessment for surface water sources using the 

Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered 

and proposed new uses. Among all the registered and proposed new uses, the highest estimated 

drinking water concentrations (EDWCs) for surface water sources were derived for aerial 

applications of difenoconazole to New York grapes at the maximum annual application rate of 

0.46 lb ai/acre. The estimated drinking water residues for 1-in-10 year annual peak, 1-in-10 year 

annual mean, and 36-year annual mean are 17.4, 11.8, and 8.6 μg/L (ppb) respectively. 

The highest Screening Concentration In GROund Water (SCI-GROW) estimated drinking water 

concentration of difenoconazole from shallow ground water sources is 1.28 x 10-2μg/L, obtained 

for the maximum application rate for ornamentals (0.52 lb ai/A; D333319). These 

concentrations can be considered as both the acute and chronic groundwater values. The 

EDWCs from ground water sources are expected to be the same for the proposed golf course turf 

uses as estimated for ornamentals.

The 1-in-10 year annual peak EDWC of 17.4 μg/L (ppb) was used for the acute dietary (food 

plus water) exposure analysis and the 1-in-10 year annual mean EDWC of 11.8 μg/L (ppb) was 

used for the chronic dietary (food plus water) exposure analysis.

IV. DEEM-FCID Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994-

1996 and 1998). The 1994-96, 98 data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 
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average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant 

differences in user vs. per capita exposure and risk are identified and noted in the risk 

assessment.

V. Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review Committee (HIARC) 

evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 1994, 

as well as the toxicological endpoints for the dietary and occupational exposure risk assessments 

that were selected in 1994. At this meeting, the HIARC also addressed the potential enhanced 

sensitivity of infants and children from exposure to difenoconazole as required by the Food 

Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998). In July, 2007, 

the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the 

HIARC since new studies were submitted. RAB1 toxicologists and risk assessment team also 

reevaluated FQPA assessments. The risk assessment team concluded that the default 10x FQPA 

Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures

(M.Sahafeyan, D333320, 09-AUG-07). The relevant endpoints are shown in Table 3.

In accordance with HED’s current policy and EPA’s 2005 Cancer Guidelines, difenoconazole is 

classified as “Suggestive Evidence of Carcinogenic Potential,” based on excessive toxicity 

observed at the two highest doses, the absence of tumors at the lower doses and the absence of 

genotoxic effects. A margin-of-exposure (MOE) approach in risk assessment was advocated by 

HED’s CPRC in 1994. Use of an MOE approach was reviewed and reaffirmed in 2007 by the 

CPRC Chair (PV Shah, 3/1/07, HED Doc. No. 0054532). Therefore, a separate cancer dietary 

assessment is not being conducted for difenoconazole.
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Table 3. Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk 

Assessments. 

Exposure 

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, for Risk 

Assessment

Study and Relevant 

Toxicological Effects

Acute Dietary 

(All 

populations)

NOAEL = 

25

mg/kg

UFA = 10X

UFH = 10X

FQPA SF = 1X 

aRfD = aPAD = 0.25 

mg/kg/day

Acute Neurotoxicity Study 

in Rats

LOAEL= 200 mg/kg in 

males based on reduced 

fore-limb grip strength in 

males on day 1.

Chronic 

Dietary (All 

populations)

NOAEL = 

0.96

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

cRfD = cPAD = 

0.01mg/kg/day

Combined chronic 

toxicity/carcinogenicity 

(rat; dietary) LOAEL = 

24.1/32.8 mg/kg/day (M/F) 

based on cumulative 

decreases in body-weight 

gains.

Cancer (oral, 

dermal, 

inhalation)

Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) 

approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated 

March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of 

cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity 

among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population 

adjusted dose (a = acute, c = chronic). RfD = reference dose. 

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the 

DEEM-FCID (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID

estimating the dietary exposure of the U.S. population and various population subgroups. The 

results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively. 

The resulting acute food exposure estimates were less than HED’s level of concern (<100% 

aPAD) at the 95th percentile of the exposure distribution for general US population (12 % aPAD) 

and all population sub-groups; the most highly exposed population subgroup was Children 1-2 

years old with 27 % aPAD. The resulting chronic food exposure estimates were less than HED’s 

level of concern (<100% cPAD) for the general U.S. population (30 % cPAD) and all population 

sub-groups; the most highly exposed population subgroup was children 1-2 years old with 75 % 

cPAD. A separate cancer dietary assessment was not conducted for difenoconazole because the 

cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is 

considered protective of all chronic effects including carcinogenicity.
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Table 4. Summary of Acute Dietary (Food plus Water) Exposure and Risk for Difenoconazole at the 95th

Percentile.

Population Subgroup aPAD (mg/kg/day) Exposure (mg/kg/day) %aPAD

General U.S. Population

0.25

0.030385 12

All Infants (< 1 year old) 0.056767 23

Children 1-2 years old 0.066505 27

Children 3-5 years old 0.053081 21

Children 6-12 years old 0.034395 14

Youth 13-19 years old 0.023787 10

Adults 20-49 years old 0.022687 9

Adults 50+ years old 0.025302 10

Females 13-49 years old 0.022729 9

The bolded %aPAD is the highest.

Table 5. Summary of Chronic Dietary (Food plus Water) Exposure and Risk for Difenoconazole.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD

General U.S. Population

0.01

0.002987 30

All Infants (< 1 year old) 0.004701 47

Children 1-2 years old 0.007460 75

Children 3-5 years old 0.006242 62

Children 6-12 years old 0.003903 39

Youth 13-19 years old 0.002574 26

Adults 20-49 years old 0.002382 24

Adults 50+ years old 0.002594 26

Females 13-49 years old 0.002304 23

The bolded %cPAD is the highest.

 

VII. Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or DEEM

default processing factors. The chronic analysis assumed tolerance-level residues for some 

commodities, average field trial residues for the majority of commodities, 100 % CT, and 

empirical or DEEM default processing factors. Therefore, these analyses are considered 

conservative. While they could be significantly refined, further refinement is not warranted as 

estimated risks are not of concern. 
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VIII. Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole 

using the DEEM-FCID (ver. 2.03) Model and assumed tolerance-level residues, 100% CT, and 

empirical or DEEM default processing factors. The chronic aggregate dietary risk assessment 

assumed tolerance-level residues for some commodities, average field trial residues for the 

majority of commodities, 100 % CT, and empirical or DEEM default processing factors. The 

resulting acute and chronic aggregate exposure estimates were less than HED’s level of concern. 

For the general U.S. population, the aPAD and cPAD were 12 % and 30 %, respectively. The 

most highly-exposed population subgroups in the acute (at the 95th percentile of the exposure 

distribution) and chronic analyses were Children 1-2 years old (27 % aPAD) and children 1-2 

years old (75 % cPAD), respectively. 

IX. Attachments

Attachment 1: DEEM-FCID Acute Residue File

Attachment 2: DEEM-FCID Acute Exposure Estimates

Attachment 3: DEEM-FCID Chronic Residue File

Attachment 4: DEEM-FCID Chronic Exposure Estimates

cc with all attachments: T. Morton (RABIV)

RDI: A. Acierto and M. Sahafeyan - DESAC (26-January-2012); S. Hummel (30-May-2012)

Petition Number(s): 1E7852

DP#: 389652

PC Code: 128847

T. Morton:S10838:PY1:(703)305-6691
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Attachment 1: DEEM-FCID Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 

1E7852 Jan 2012\difenoconazole_acute-01-12 wheat barley at tolerance.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-07-2012/12:32:14/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010520 1A Beet, sugar 0.300000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

01010780 1AB Carrot 0.500000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.500000 1.000 1.000 

01010790 1AB Carrot, juice 0.500000 1.000 1.000 

01030150 1CD Arrowroot, flour 4.000000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 4.000000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 4.000000 1.000 1.000 

01030820 1CD Cassava 4.000000 1.000 1.000 

01030821 1CD Cassava-babyfood 4.000000 1.000 1.000 

01031390 1CD Dasheen, corm 4.000000 1.000 1.000 

01031660 1CD Ginger 4.000000 1.000 1.000 

01031661 1CD Ginger-babyfood 4.000000 1.000 1.000 

01031670 1CD Ginger, dried 4.000000 1.000 1.000 

01032960 1C Potato, chips 4.000000 0.500 1.000 

01032970 1C Potato, dry (granules/ flakes) 4.000000 0.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 4.000000 0.500 1.000 

01032980 1C Potato, flour 4.000000 0.500 1.000 

01032981 1C Potato, flour-babyfood 4.000000 0.500 1.000 

01032990 1C Potato, tuber, w/peel 4.000000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 4.000000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 4.000000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 4.000000 1.000 1.000 

01033660 1CD Sweet potato 4.000000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 4.000000 1.000 1.000 

01033710 1CD Tanier, corm 4.000000 1.000 1.000 

01033870 1CD Turmeric 4.000000 1.000 1.000 

01034060 1CD Yam, true 4.000000 1.000 1.000 

01034070 1CD Yam bean 4.000000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

03001980 3 Leek 6.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 6.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

05010610 5A Broccoli 1.900000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.900000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.900000 1.000 1.000 

05010640 5A Brussels sprouts 1.900000 1.000 1.000 

05010690 5A Cabbage 1.900000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 

05010830 5A Cauliflower 1.900000 1.000 1.000 

05011960 5A Kohlrabi 1.900000 1.000 1.000 

05020630 5B Broccoli raab 35.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000 

05021170 5B Collards 35.000000 1.000 1.000 

05021940 5B Kale 35.000000 1.000 1.000 

05022290 5B Mustard greens 35.000000 1.000 1.000 

05023180 5B Rape greens 35.000000 1.000 1.000 

05023890 5B Turnip, greens 35.000000 1.000 1.000 

06003470 6 Soybean, seed 0.150000 1.000 1.000 

06003480 6 Soybean, flour 0.150000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.150000 1.000 1.000 

06003490 6 Soybean, soy milk 0.150000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.150000 1.000 1.000 

06003500 6 Soybean, oil 0.150000 1.000 1.000 
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06003501 6 Soybean, oil-babyfood 0.150000 1.000 1.000 

06030980 6C Chickpea, seed 0.080000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.080000 1.000 1.000 

06030990 6C Chickpea, flour 0.080000 1.000 1.000 

08001480 8 Eggplant 0.600000 1.000 1.000 

08002340 8 Okra 0.600000 1.000 1.000 

08002700 8 Pepper, bell 0.600000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.600000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.600000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.600000 1.000 1.000 

08002720 8 Pepper, nonbell 0.600000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.600000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.600000 1.000 1.000 

08003740 8 Tomatillo 0.600000 1.000 1.000 

08003750 8 Tomato 0.600000 1.000 1.000 

08003751 8 Tomato-babyfood 0.600000 1.000 1.000 

08003760 8 Tomato, paste 0.600000 1.600 1.000 

08003761 8 Tomato, paste-babyfood 0.600000 1.600 1.000 

08003770 8 Tomato, puree 0.600000 0.500 1.000 

08003771 8 Tomato, puree-babyfood 0.600000 0.500 1.000 

08003780 8 Tomato, dried 0.600000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.600000 14.300 1.000 

08003790 8 Tomato, juice 0.600000 1.500 1.000 

09010750 9A Cantaloupe 0.700000 1.000 1.000 

09010800 9A Casaba 0.700000 1.000 1.000 

09011870 9A Honeydew melon 0.700000 1.000 1.000 

09013990 9A Watermelon 0.700000 1.000 1.000 

09014000 9A Watermelon, juice 0.700000 1.000 1.000 

09020210 9B Balsam pear 0.700000 1.000 1.000 

09020880 9B Chayote, fruit 0.700000 1.000 1.000 

09021020 9B Chinese waxgourd 0.700000 1.000 1.000 

09021350 9B Cucumber 0.700000 1.000 1.000 

09023080 9B Pumpkin 0.700000 1.000 1.000 

09023090 9B Pumpkin, seed 0.700000 1.000 1.000 

09023560 9B Squash, summer 0.700000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.700000 1.000 1.000 

09023570 9B Squash, winter 0.700000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.700000 1.000 1.000 

10001060 10 Citrus citron 0.600000 1.000 1.000 

10001070 10 Citrus hybrids 0.600000 1.000 1.000 

10001080 10 Citrus, oil 25.000000 1.000 1.000 

10001800 10 Grapefruit 0.600000 1.000 1.000 

10001810 10 Grapefruit, juice 0.600000 0.100 1.000 

10001970 10 Kumquat 0.600000 1.000 1.000 

10001990 10 Lemon 0.600000 1.000 1.000 

10002000 10 Lemon, juice 0.600000 0.100 1.000 

10002001 10 Lemon, juice-babyfood 0.600000 0.100 1.000 

10002010 10 Lemon, peel 0.600000 1.000 1.000 

10002060 10 Lime 0.600000 1.000 1.000 

10002070 10 Lime, juice 0.600000 0.100 1.000 

10002071 10 Lime, juice-babyfood 0.600000 0.100 1.000 

10002400 10 Orange 0.600000 1.000 1.000 

10002410 10 Orange, juice 0.600000 0.100 1.000 

10002411 10 Orange, juice-babyfood 0.600000 0.100 1.000 

10002420 10 Orange, peel 0.600000 1.000 1.000 

10003070 10 Pummelo 0.600000 1.000 1.000 

10003690 10 Tangerine 0.600000 1.000 1.000 

10003700 10 Tangerine, juice 0.600000 0.100 1.000 

11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 

11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

11000090 11 Apple, dried 1.000000 8.000 1.000 

11000091 11 Apple, dried-babyfood 1.000000 8.000 1.000 

11000100 11 Apple, juice 1.000000 0.040 1.000 

11000101 11 Apple, juice-babyfood 1.000000 0.040 1.000 

11000110 11 Apple, sauce 1.000000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 1.000000 1.000 1.000 

11001290 11 Crabapple 1.000000 1.000 1.000 

11002100 11 Loquat 1.000000 1.000 1.000 

11002660 11 Pear 1.000000 1.000 1.000 

11002661 11 Pear-babyfood 1.000000 1.000 1.000 

11002670 11 Pear, dried 1.000000 6.250 1.000 

11002680 11 Pear, juice 1.000000 1.000 1.000 

11002681 11 Pear, juice-babyfood 1.000000 1.000 1.000 

11003100 11 Quince 1.000000 1.000 1.000 

12000120 12 Apricot 2.500000 1.000 1.000 

12000121 12 Apricot-babyfood 2.500000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

14 of 21

12000130 12 Apricot, dried 2.500000 1.000 1.000 

12000140 12 Apricot, juice 2.500000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 2.500000 1.000 1.000 

12000900 12 Cherry 2.500000 1.000 1.000 

12000901 12 Cherry-babyfood 2.500000 1.000 1.000 

12000910 12 Cherry, juice 2.500000 1.000 1.000 

12000911 12 Cherry, juice-babyfood 2.500000 1.000 1.000 

12002300 12 Nectarine 2.500000 1.000 1.000 

12002600 12 Peach 2.500000 1.000 1.000 

12002601 12 Peach-babyfood 2.500000 1.000 1.000 

12002610 12 Peach, dried 2.500000 1.000 1.000 

12002611 12 Peach, dried-babyfood 2.500000 1.000 1.000 

12002620 12 Peach, juice 2.500000 1.000 1.000 

12002621 12 Peach, juice-babyfood 2.500000 1.000 1.000 

12002850 12 Plum 2.500000 1.000 1.000 

12002851 12 Plum-babyfood 2.500000 1.000 1.000 

12002860 12 Plum, prune, fresh 2.500000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 2.500000 1.000 1.000 

12002870 12 Plum, prune, dried 2.500000 1.000 1.000 

12002871 12 Plum, prune, dried-babyfood 2.500000 1.000 1.000 

12002880 12 Plum, prune, juice 2.500000 1.000 1.000 

12002881 12 Plum, prune, juice-babyfood 2.500000 1.000 1.000 

13020570 13B Blueberry 2.500000 1.000 1.000 

13020571 13B Blueberry-babyfood 2.500000 1.000 1.000 

14000030 14 Almond 0.030000 1.000 1.000 

14000031 14 Almond-babyfood 0.030000 1.000 1.000 

14000040 14 Almond, oil 0.030000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.030000 1.000 1.000 

14000590 14 Brazil nut 0.030000 1.000 1.000 

14000680 14 Butternut 0.030000 1.000 1.000 

14000810 14 Cashew 0.030000 1.000 1.000 

14000920 14 Chestnut 0.030000 1.000 1.000 

14001550 14 Filbert 0.030000 1.000 1.000 

14001560 14 Filbert, oil 0.030000 1.000 1.000 

14001850 14 Hickory nut 0.030000 1.000 1.000 

14002130 14 Macadamia nut 0.030000 1.000 1.000 

14002690 14 Pecan 0.030000 1.000 1.000 

14002820 14 Pistachio 0.030000 1.000 1.000 

14003910 14 Walnut 0.030000 1.000 1.000 

15000250 15 Barley, pearled barley 0.100000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 

15000260 15 Barley, flour 0.100000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.100000 1.000 1.000 

15000270 15 Barley, bran 0.100000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15002310 15 Oat, bran 0.010000 1.000 1.000 

15002320 15 Oat, flour 0.010000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.010000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.010000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 

15003280 15 Rye, grain 0.010000 1.000 1.000 

15003290 15 Rye, flour 0.010000 1.000 1.000 

15004010 15 Wheat, grain 0.100000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

15004020 15 Wheat, flour 0.100000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.100000 1.000 1.000 

15004030 15 Wheat, germ 0.100000 1.000 1.000 

15004040 15 Wheat, bran 0.100000 1.000 1.000 

20003190 20 Rapeseed, oil 0.010000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.010000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.400000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.400000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.400000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

15 of 21

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.400000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.400000 1.000 1.000 

27002220 D Milk, fat 0.015000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.015000 1.000 1.000 

27012230 D Milk, nonfat solids 0.015000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.015000 1.000 1.000 

27022240 D Milk, water 0.015000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.015000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.015000 1.000 1.000 

70001450 P Egg, whole 0.020000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.020000 1.000 1.000 

70001460 P Egg, white 0.020000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.020000 1.000 1.000 

70001470 P Egg, yolk 0.020000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.017400 1.000 1.000 

86020000 O Water, indirect, all sources 0.017400 1.000 1.000 

95000230 O Banana 0.200000 1.000 1.000 

95000231 O Banana-babyfood 0.200000 1.000 1.000 

95000240 O Banana, dried 0.200000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 

95001280 O Cottonseed, oil 0.050000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 

95001750 O Grape 4.000000 1.000 1.000 

95001760 O Grape, juice 4.000000 0.200 1.000 

95001761 O Grape, juice-babyfood 4.000000 0.200 1.000 

95001770 O Grape, leaves 4.000000 1.000 1.000 

95001780 O Grape, raisin 6.000000 1.000 1.000 

95001790 O Grape, wine and sherry 4.000000 1.000 1.000 

95002150 O Mango 0.070000 1.000 1.000 

95002151 O Mango-babyfood 0.070000 1.000 1.000 

95002160 O Mango, dried 0.070000 1.000 1.000 

95002170 O Mango, juice 0.070000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 

95002450 O Papaya 0.300000 1.000 1.000 

95002451 O Papaya-babyfood 0.300000 1.000 1.000 

95002460 O Papaya, dried 0.300000 1.800 1.000 

95002470 O Papaya, juice 0.300000 1.500 1.000 

95002830 O Plantain 0.200000 1.000 1.000 

95002840 O Plantain, dried 0.200000 3.900 1.000 

95003590 O Strawberry 2.500000 1.000 1.000 

95003591 O Strawberry-babyfood 2.500000 1.000 1.000 

95003600 O Strawberry, juice 2.500000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 2.500000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

16 of 21

Attachment 2: DEEM-FCID Acute Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE (1994-98 data)

Residue file: difenoconazole_acute-01-12 wheat barley at tolerance.R98

 Adjustment factor #2 used.

Analysis Date: 02-22-2012/13:40:53 Residue file dated: 02-22-2012/13:38:41/8

Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

U.S. Population:

 0.030385 12.15 0.067004 26.80 0.154531 61.81 

All infants:

 0.056767 22.71 0.094429 37.77 0.140489 56.20 

Children 1-2 yrs:

 0.066505 26.60 0.110223 44.09 0.262525 105.01 

Children 3-5 yrs:

 0.053081 21.23 0.097507 39.00 0.381012 152.40 

Children 6-12 yrs:

 0.034395 13.76 0.059641 23.86 0.148121 59.25 

Youth 13-19 yrs:

 0.023787 9.51 0.052679 21.07 0.138411 55.36 

Adults 20-49 yrs:

 0.022687 9.07 0.048712 19.48 0.116353 46.54 

Adults 50+ yrs:

 0.025302 10.12 0.067231 26.89 0.149167 59.67 

Females 13-49 yrs:

 0.022729 9.09 0.048698 19.48 0.121607 48.64
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

17 of 21

Attachment 3: DEEM-FCID Chronic Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 

1E7852 Jan 2012\difenoconazole_chronic-01-12AverageFT wheat barley at tolerance.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-07-2012/12:33:37/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010520 1A Beet, sugar 0.300000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

01010780 1AB Carrot 0.062000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.062000 1.000 1.000 

01010790 1AB Carrot, juice 0.062000 1.000 1.000 

01030150 1CD Arrowroot, flour 1.360000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 1.360000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 1.360000 1.000 1.000 

01030820 1CD Cassava 1.360000 1.000 1.000 

01030821 1CD Cassava-babyfood 1.360000 1.000 1.000 

01031390 1CD Dasheen, corm 1.360000 1.000 1.000 

01031660 1CD Ginger 1.360000 1.000 1.000 

01031661 1CD Ginger-babyfood 1.360000 1.000 1.000 

01031670 1CD Ginger, dried 1.360000 1.000 1.000 

01032960 1C Potato, chips 1.360000 0.500 1.000 

01032970 1C Potato, dry (granules/ flakes) 1.360000 0.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 1.360000 0.500 1.000 

01032980 1C Potato, flour 1.360000 0.500 1.000 

01032981 1C Potato, flour-babyfood 1.360000 0.500 1.000 

01032990 1C Potato, tuber, w/peel 1.360000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 1.360000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 1.360000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 1.360000 1.000 1.000 

01033660 1CD Sweet potato 1.360000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 1.360000 1.000 1.000 

01033710 1CD Tanier, corm 1.360000 1.000 1.000 

01033870 1CD Turmeric 1.360000 1.000 1.000 

01034060 1CD Yam, true 1.360000 1.000 1.000 

01034070 1CD Yam bean 1.360000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

03001980 3 Leek 6.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 6.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

05010610 5A Broccoli 0.221000 1.000 1.000 

05010611 5A Broccoli-babyfood 0.221000 1.000 1.000 

05010620 5A Broccoli, Chinese 0.221000 1.000 1.000 

05010640 5A Brussels sprouts 0.029000 1.000 1.000 

05010690 5A Cabbage 0.029000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 0.029000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 0.221000 1.000 1.000 

05010830 5A Cauliflower 0.221000 1.000 1.000 

05011960 5A Kohlrabi 0.029000 1.000 1.000 

05020630 5B Broccoli raab 5.100000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 5.100000 1.000 1.000 

05021170 5B Collards 5.100000 1.000 1.000 

05021940 5B Kale 5.100000 1.000 1.000 

05022290 5B Mustard greens 5.100000 1.000 1.000 

05023180 5B Rape greens 5.100000 1.000 1.000 

05023890 5B Turnip, greens 5.100000 1.000 1.000 

06003470 6 Soybean, seed 0.021500 1.000 1.000 

06003480 6 Soybean, flour 0.021500 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.021500 1.000 1.000 

06003490 6 Soybean, soy milk 0.021500 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.021500 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

18 of 21

06003500 6 Soybean, oil 0.021500 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.021500 1.000 1.000 

06030980 6C Chickpea, seed 0.017000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.017000 1.000 1.000 

06030990 6C Chickpea, flour 0.017000 1.000 1.000 

08001480 8 Eggplant 0.133000 1.000 1.000 

08002340 8 Okra 0.600000 1.000 1.000 

08002700 8 Pepper, bell 0.133000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.133000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.133000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.133000 1.000 1.000 

08002720 8 Pepper, nonbell 0.133000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.133000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.133000 1.000 1.000 

08003740 8 Tomatillo 0.165000 1.000 1.000 

08003750 8 Tomato 0.165000 1.000 1.000 

08003751 8 Tomato-babyfood 0.165000 1.000 1.000 

08003760 8 Tomato, paste 0.165000 1.600 1.000 

08003761 8 Tomato, paste-babyfood 0.165000 1.600 1.000 

08003770 8 Tomato, puree 0.165000 0.500 1.000 

08003771 8 Tomato, puree-babyfood 0.165000 0.500 1.000 

08003780 8 Tomato, dried 0.165000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.165000 14.300 1.000 

08003790 8 Tomato, juice 0.165000 1.500 1.000 

09010750 9A Cantaloupe 0.137000 1.000 1.000 

09010800 9A Casaba 0.137000 1.000 1.000 

09011870 9A Honeydew melon 0.137000 1.000 1.000 

09013990 9A Watermelon 0.137000 1.000 1.000 

09014000 9A Watermelon, juice 0.137000 1.000 1.000 

09020210 9B Balsam pear 0.055000 1.000 1.000 

09020880 9B Chayote, fruit 0.310000 1.000 1.000 

09021020 9B Chinese waxgourd 0.055000 1.000 1.000 

09021350 9B Cucumber 0.055000 1.000 1.000 

09023080 9B Pumpkin 0.031000 1.000 1.000 

09023090 9B Pumpkin, seed 0.031000 1.000 1.000 

09023560 9B Squash, summer 0.031000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.031000 1.000 1.000 

09023570 9B Squash, winter 0.031000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.031000 1.000 1.000 

10001060 10 Citrus citron 0.208000 1.000 1.000 

10001070 10 Citrus hybrids 0.208000 1.000 1.000 

10001080 10 Citrus, oil 25.000000 1.000 1.000 

10001800 10 Grapefruit 0.120000 1.000 1.000 

10001810 10 Grapefruit, juice 0.120000 0.100 1.000 

10001970 10 Kumquat 0.208000 1.000 1.000 

10001990 10 Lemon 0.176000 1.000 1.000 

10002000 10 Lemon, juice 0.176000 0.100 1.000 

10002001 10 Lemon, juice-babyfood 0.176000 0.100 1.000 

10002010 10 Lemon, peel 0.176000 1.000 1.000 

10002060 10 Lime 0.176000 1.000 1.000 

10002070 10 Lime, juice 0.176000 0.100 1.000 

10002071 10 Lime, juice-babyfood 0.176000 0.100 1.000 

10002400 10 Orange 0.208000 1.000 1.000 

10002410 10 Orange, juice 0.208000 0.100 1.000 

10002411 10 Orange, juice-babyfood 0.208000 0.100 1.000 

10002420 10 Orange, peel 0.208000 1.000 1.000 

10003070 10 Pummelo 0.120000 1.000 1.000 

10003690 10 Tangerine 0.208000 1.000 1.000 

10003700 10 Tangerine, juice 0.208000 0.100 1.000 

11000070 11 Apple, fruit with peel 0.203000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.203000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.203000 1.000 1.000 

11000090 11 Apple, dried 0.203000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.203000 8.000 1.000 

11000100 11 Apple, juice 0.203000 0.040 1.000 

11000101 11 Apple, juice-babyfood 0.203000 0.040 1.000 

11000110 11 Apple, sauce 0.203000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.203000 1.000 1.000 

11001290 11 Crabapple 0.203000 1.000 1.000 

11002100 11 Loquat 0.123000 1.000 1.000 

11002660 11 Pear 0.123000 1.000 1.000 

11002661 11 Pear-babyfood 0.123000 1.000 1.000 

11002670 11 Pear, dried 0.123000 6.250 1.000 

11002680 11 Pear, juice 0.123000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.123000 1.000 1.000 

11003100 11 Quince 0.123000 1.000 1.000 

12000120 12 Apricot 0.421000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

19 of 21

12000121 12 Apricot-babyfood 0.421000 1.000 1.000 

12000130 12 Apricot, dried 0.421000 1.000 1.000 

12000140 12 Apricot, juice 0.421000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.421000 1.000 1.000 

12000900 12 Cherry 0.622000 1.000 1.000 

12000901 12 Cherry-babyfood 0.622000 1.000 1.000 

12000910 12 Cherry, juice 0.622000 1.000 1.000 

12000911 12 Cherry, juice-babyfood 0.622000 1.000 1.000 

12002300 12 Nectarine 0.421000 1.000 1.000 

12002600 12 Peach 0.421000 1.000 1.000 

12002601 12 Peach-babyfood 0.421000 1.000 1.000 

12002610 12 Peach, dried 0.421000 1.000 1.000 

12002611 12 Peach, dried-babyfood 0.421000 1.000 1.000 

12002620 12 Peach, juice 0.421000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.421000 1.000 1.000 

12002850 12 Plum 0.295000 1.000 1.000 

12002851 12 Plum-babyfood 0.295000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.295000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.295000 1.000 1.000 

12002870 12 Plum, prune, dried 0.295000 2.600 1.000 

12002871 12 Plum, prune, dried-babyfood 0.295000 2.600 1.000 

12002880 12 Plum, prune, juice 0.295000 1.000 1.000 

12002881 12 Plum, prune, juice-babyfood 0.295000 1.000 1.000 

13020570 13B Blueberry 0.495000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.495000 1.000 1.000 

14000030 14 Almond 0.005000 1.000 1.000 

14000031 14 Almond-babyfood 0.005000 1.000 1.000 

14000040 14 Almond, oil 0.005000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.005000 1.000 1.000 

14000590 14 Brazil nut 0.007000 1.000 1.000 

14000680 14 Butternut 0.007000 1.000 1.000 

14000810 14 Cashew 0.007000 1.000 1.000 

14000920 14 Chestnut 0.005000 1.000 1.000 

14001550 14 Filbert 0.007000 1.000 1.000 

14001560 14 Filbert, oil 0.007000 1.000 1.000 

14001850 14 Hickory nut 0.007000 1.000 1.000 

14002130 14 Macadamia nut 0.007000 1.000 1.000 

14002690 14 Pecan 0.007000 1.000 1.000 

14002820 14 Pistachio 0.005000 1.000 1.000 

14003910 14 Walnut 0.007000 1.000 1.000 

15000250 15 Barley, pearled barley 0.100000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 

15000260 15 Barley, flour 0.100000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.100000 1.000 1.000 

15000270 15 Barley, bran 0.100000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15002310 15 Oat, bran 0.010000 1.000 1.000 

15002320 15 Oat, flour 0.010000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.010000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.010000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 

15003280 15 Rye, grain 0.010000 1.000 1.000 

15003290 15 Rye, flour 0.010000 1.000 1.000 

15004010 15 Wheat, grain 0.100000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

15004020 15 Wheat, flour 0.100000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.100000 1.000 1.000 

15004030 15 Wheat, germ 0.100000 1.000 1.000 

15004040 15 Wheat, bran 0.100000 1.000 1.000 

20003190 20 Rapeseed, oil 0.010000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.010000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.400000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.400000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.400000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

20 of 21

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.400000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.400000 1.000 1.000 

27002220 D Milk, fat 0.010000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

70001450 P Egg, whole 0.020000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.020000 1.000 1.000 

70001460 P Egg, white 0.020000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.020000 1.000 1.000 

70001470 P Egg, yolk 0.020000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.011800 1.000 1.000 

86020000 O Water, indirect, all sources 0.011800 1.000 1.000 

95000230 O Banana 0.200000 1.000 1.000 

95000231 O Banana-babyfood 0.200000 1.000 1.000 

95000240 O Banana, dried 0.200000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 

95001280 O Cottonseed, oil 0.050000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 

95001750 O Grape 0.613000 1.000 1.000 

95001760 O Grape, juice 0.613000 0.200 1.000 

95001761 O Grape, juice-babyfood 0.613000 0.200 1.000 

95001770 O Grape, leaves 0.613000 1.000 1.000 

95001780 O Grape, raisin 0.613000 3.500 1.000 

95001790 O Grape, wine and sherry 0.613000 1.000 1.000 

95002150 O Mango 0.070000 1.000 1.000 

95002151 O Mango-babyfood 0.070000 1.000 1.000 

95002160 O Mango, dried 0.070000 1.000 1.000 

95002170 O Mango, juice 0.070000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 

95002450 O Papaya 0.300000 1.000 1.000 

95002451 O Papaya-babyfood 0.300000 1.000 1.000 

95002460 O Papaya, dried 0.300000 1.800 1.000 

95002470 O Papaya, juice 0.300000 1.500 1.000 

95002830 O Plantain 0.200000 1.000 1.000 

95002840 O Plantain, dried 0.200000 3.900 1.000 

95003590 O Strawberry 0.495000 1.000 1.000 

95003591 O Strawberry-babyfood 0.495000 1.000 1.000 

95003600 O Strawberry, juice 0.495000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.495000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 397664

PC Code: 128847

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Attachment 4: DEEM-FCID Chronic Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for DIFENOCONAZOLE (1994-98 data)

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

Difenoconazole 1E7852 Jan 2012\difenoconazole_chronic-01-12AverageFT wheat barley at 

tolerance.R98

 Adjustment factor #2 used.

Analysis Date 02-22-2012/13:42:37 Residue file dated: 02-22-2012/13:39:12/8

Reference dose (RfD, Chronic) = .01 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.002987 29.9%

U.S. Population (spring season) 0.002974 29.7%

U.S. Population (summer season) 0.003013 30.1%

U.S. Population (autumn season) 0.003022 30.2%

U.S. Population (winter season) 0.002935 29.3%

Northeast region 0.002890 28.9%

Midwest region 0.003081 30.8%

Southern region 0.002911 29.1%

Western region 0.003095 31.0%

Hispanics 0.003058 30.6%

Non-hispanic whites 0.002892 28.9%

Non-hispanic blacks 0.003214 32.1%

Non-hisp/non-white/non-black 0.003732 37.3%

All infants (< 1 year) 0.004701 47.0%

Nursing infants 0.002496 25.0%

Non-nursing infants 0.005539 55.4%

Children 1-6 yrs 0.006440 64.4%

Children 7-12 yrs 0.003708 37.1%

Females 13-19 (not preg or nursing) 0.002301 23.0%

Females 20+ (not preg or nursing) 0.002402 24.0%

Females 13-50 yrs 0.002455 24.5%

Females 13+ (preg/not nursing) 0.002384 23.8%

Females 13+ (nursing) 0.002707 27.1%

Males 13-19 yrs 0.002844 28.4%

Males 20+ yrs 0.002516 25.2%

Seniors 55+ 0.002645 26.4%

Children 1-2 yrs 0.007460 74.6%

Children 3-5 yrs 0.006242 62.4%

Children 6-12 yrs 0.003903 39.0%

Youth 13-19 yrs 0.002574 25.7%

Adults 20-49 yrs 0.002382 23.8%

Adults 50+ yrs 0.002594 25.9%

Females 13-49 yrs 0.002304 23.0%

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