### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 3 of 21 PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

- 1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton ( 26

- October

- 20 1 1 ; DP# 3 89652 ).

II. Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock :

Residues of concern were determined based on recommendations from the HED Residues of Concern Knowledgebase Sub

- committee (R OCKS) (D391350, 9/19/11). The residue of concern for plant commodities for tolerance expression and risk assessment purposes is difenoconazole

per se . The HED ROCKS has determined that the parent compound and the CGA

- 205375

metabolite are the residues of concern in livestock commodities for both the tolerance expression and the risk assessment. In addition, metabolite OH

- CGA

- 169374, which comprised 15% of the TRR in goat milk from the phenyl

- labeled study, should be considered as a residue of concern for the dietary risk assessment. Based on available goat metabolism data, total residues of concern in milk for dietary risk assessments (parent, CGA

- 205375, and OH

- CGA

- 169374), should be calculated by multiplying the tolerance in milk by a factor of 1.5x. T able 1 summarizes tolerance expression and the residues of concern in plant and livestock commodities.

Table 1 . Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants Primary and Rotational crops Parent Only Parent Only

Livestock Ruminant and Poultry Parent and CGA 205375 Parent and CGA 205375

Milk Parent, CGA 205375 and

OH

- CGA

- 169374 Parent and CGA 205375

Drinking Water Parent Only NA

Note: The triazole

- containi ng metabolites 1,2,4

- T, TA, and TAA should be included in the residues of concern for risk assessment purposes only for plant and livestock commodities. Since these metabolites are common to the entire class of

traizole

- derivative fungicides and because o f differential toxicity between metabolites and the various parent compounds, risks associated with exposure to 1,2,4

- T and to TA/TAA are addressed separately.



## Recommended Tolerances : Based on the residue chemistry data submitted with the previous petiti ons, HED recommended for establishment of the new food toleranc es ( DP# 36 6507

, B

. Cropp

- Ko h lligian

, 30

- May

- 20 1 2 ). The recommended , established, and revised tolerances are

listed in Table 2 below.

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 4 of 21 Table 2 . Tolerance Summary for Difenoconazole (no n feed items)

. Commodity Existing/ Established Tolerances (ppm) New Tolerances (ppm)

Almond, nutmeat 0.0 3

------ Brassica subgroup 5A 1.9

------ Brassica subgroup 5B 35

------
Citrus oil 25

------ Fruit, citrus, group 10 0.6

------ Grape 4.0

------ Grape, raisin 6.0

------ Nut, tree, group 14 0.03

------ Onion, bulb, subgroup 3

— 07A 0.20

------ Onion, green, subgroup 3

— 07B 6.0

------
Pistachios 0.03

------ Vegetable, cucurbit, group 9 0.7

------ Fruit, Pome, g roup 11 1.0

------ Vegetable, Fruit ing, Group 8 0.60

------ Vegetable, Tuberous and Corm, subgroup 1C 0.01 4.0

Beet, sugar 0.30

------ Papaya 0.30

------
Banana 0.2

------ Barley, grain 0.1

------ Canola, seed 0.01

------
Cattle fat 0. 10

------ Cattle, meat 0.05

------ Cattle, meat byproducts 0.10

------ Cattle, liver 0. 4 0

------ Corn, sweet, kernel plus cob

with husks removed 0.01

------

Cotton, undelinted seed 0.0 5

------ Egg 0. 02

------ Goat, fat 0.10

------ Goat, meat 0.05

------ Goat, meat byproducts (except liver) 0.10

------

Goat, liver 0. 4 0

------ Hog, fat 0.10

------ Hog, meat 0.05

------ Hog, meat byproducts (except liver) 0.1

------

Hog, liver 0. 4 0

------ Horse, fat 0.10

------ Horse, meat 0.05

------ Horse, meat byproducts (except 0. 10

------

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 5 of 21 Table 2 . Tolerance Summary for Difenoconazole (no n feed items)

. Commodity Existing/ Established Tolerances (ppm) New Tolerances (ppm)

liver)

Horse, liver 0. 4 0

------
Milk 0.01

------ Rye, grain 0. 0 1

------ Sheep, fat 0. 10

------ Sheep, meat 0.05

------ Sheep, meat byproducts (except liver) 0. 10

------

Sheep, liver 0. 40

------ Wheat, grain 0.1

------ Wax apple 0.07

------ Mango 0.07

------
C arrot 0.50

------ Chickpea 0.08

------ Soybean, seed 0.15

------ Fruit, stone, group 12 2.5

------ Strawberry 2.5

------ Turnip greens 35

------ Oat, grain 0.01

------



## The dietary exposure analyses for the triazole metabolites (D397591, T. Morton, 19 Jan. 2012) was updated

.

Food Residues and processing factors used in the Acute and Chronic Analysis : The acute analys i s assumed tolerance

- level residues and 100% CT for all the registered and proposed crops.

T olerance

- level residues were also assumed for all livestock tissues in this assessment. The chronic analysis as sumed tolerance

- level residues for some commodities, average field trial residues for the majority of commodities, and 100 % CT

. Those commodities where field trial

data were used are summarized below. HED SOP 2000.1 Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other

commodities in the crop group. Experimental processing factors were used for apple juice (0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), raisin (3.5x chronic only since the raisin tolerance was used in acute ), sugar be et molasses (0.6x), tomato paste (1.6x), and tomato puree (0.5x); DEEM (ver. 7. 81 ) default process ing factors

were assumed for other processed commodities.

Almond : Field trial residues were used from MRID 47586101.

Apple : Field trial residues were u sed from MRID 46950233.

Broccoli : Field trial residues were used from MRID 47586102. Residues from 1

- 7 day PHI were used since registered labels allow from 1

- 7 day PHIs.

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 6 of 21 Cabbage : Field trial residues were used from 47586102. Residues from 1

- 7 day PHI were used since registered labels allow from 1

- 7 day PHIs. To refine the dietary exposure data from only cabbage samples without wrapper leaves were used.

Cantaloupe : Field trial residues were used from MRID 4758610 3 . Residues from 0

- 1 day PHI

were used since registered labels allow from 0

- 1 day PHI.

Carrot : Field trial residues were used from MRID 47929804.

Chickpea : Field trial residues were used from MRID 47929805.

Cucumber : Field trial residues were used from MRID 47586103. Residues from 0

- 1 day PHI were used since registered labels allow from 0

- 1 day PHI.

Grape : Field trial residues were used from MRID 47586105.

Grapefruit : Field trial residues were used from MRID 47586104.

Lemon : Field trial residues were used from MRID 47586104.

Lime : Field trial residues were used from MRID 47586104.

Mustard Greens : Field trial residues were used from MRIDs 47417704, 47417707, and

47586102. Residues from 1

- 7 day PHI were used since registered labels allow from 1

- 7 day

PHIs.

Orange : Field trial residues w ere used from MRID 47586104.

Pear : Field trial residues were used from MRID 46950233.

Pecan : Field trial residues were used from MRID 47586106.

Peppers : Field trial residues were used from MRID 46950234.

Potato : Field trial residues were used from MRID 47929804

.

Soybean : Field trial residues were used from MRID 47929801.

Stone Fruit : Field trial residues were used from MRID 47929803.

Strawberry : Field trial residues were used from MRID 47929802.

Sugar Beet : Field trial residues were used from MRID 4 6950236.

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 7 of 21 Summer Squash : Field trial residues were used from MRID 47586103. Residues from 0

- 1 day PHI were used since registered labels allow from 0

- 1 day PHI s

.

Tomato : Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

III. Drink ing Water Data

The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED; Memo, F

. Khan

, 23

- February

- 201 2 ; D3 98836 ). EFED conducted a Tier II drinking water assessment for surface water sources using the Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/ EXAMS ) for the registered and proposed new uses. Among all the registered and proposed new uses, the highest estimated drinking water concentrations (EDWCs) f or surface wa ter sources were derived for aerial applications of difenoconazole to New York grapes at the maximum annual applicati on rate of 0.46 lb ai/acre. The estimated drinking water residues for 1

- in

- 10 year annual peak, 1

- in

- 10 year annual mean, and 36

- year annua l mean are 17.4

, 11.8 , and 8.6 μg/L (ppb) respectively.

The highest S creening C oncentration In GRO und W ater ( SCI

- GROW ) estimated drinking water

concentration of difenoconazole from sh allow ground water sources is 1.28 x 10 - 2 

## μg/L

, obtained

for the maxim um application rate for ornamentals (0.52 lb ai/A; D333319 ) . These

concentrations can be considered as both the acute and chronic groundwater values. The EDWCs from ground water sources are expected to be the same for the proposed golf course turf

uses a s estimated for ornamentals.

The 1

- in

- 10 year annual peak EDWC of 17.4 μg/L (ppb) was used for the acute dietary (food plus water) exposure analysis and the 1

- in

- 10 year annual mean EDWC of 1 1

. 8 μg/L (ppb) was used for the chronic dietary (food plus water) exposure analysis.

I V

. DEEM

- FCID Program and Consumption Informat ion

Difenoconazole acute and chronic dietary exposure assessments were conducted using the

DEEM

- FCID (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994

- 1996 and 1998). The 1994

- 96, 98 data are based on the reported consumption of m ore than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” ( e

. g

. , apple pie)

are linked to EPA

- defined food commodities ( e .g

. , apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) usi ng publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute
exposure assessment are reta ined as individual consumption events. Based on analysis of the

1994

- 96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subg roups: the general U.S. population, all infants (<1 year old), children 1

- 2,

children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in eac h food or food

form ( e .g

. , orange or orange juice) on the food commodity residue list is multiplied by the

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 8 of 21 average daily consumption estimate for that food/food form. The resulting residue consumption

estimate for each food/food form is summed with the re sidue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each p opulation subgroup.

For acute exposure assessments, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obt ain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user ( i.e. , those who reported eating relevant commodities/food forms) and a per

- capita ( i.e. , those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk

assessment.

V. Toxicological Information

On 08

- SEP

- 1998, HED’s Hazard I dentification Assessment Review Committee (HIARC) evaluated the toxicology database of difenoconazole and re

- assessed the RfD established in 1994, as well as the toxicological endpoints for the dietary and occupational exposure risk assessments

that were s elected in 1994. At this meeting, the HIARC also addressed the potential enhanced sensitivity of infants and children from exposure to difenoconazole as required by the Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25

- SEP

- 1998). In Jul y, 2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the HIARC since new studies were submitted. RAB1 toxicologists and risk assessment team also reevaluated FQPA assessments. The risk assessment team concl uded that the default 10x FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures ( M. Sahafeyan, D333320, 09

- AUG

- 07) . The relevant endpoints are shown in Table 3.

In accordance with HED’s current policy and EPA’s 2005 Cancer Guidelines, difenoconazole is classified as “Suggestive Evidence of Carcinogenic Potential,” b ased on excessive toxicity observed at the two highest doses, the absence of tumors at the lower doses and the absence of genotoxic effects

. A marg in

- of

- exposure (MOE) approach in risk assessment was advocated by HED’s CPRC in 1994. Use of an MOE approach was reviewed and reaffirmed in 2007 by the

CPRC Chair (PV Shah, 3/1/07, HED Doc. No. 0054532). Therefore, a separate cancer dietary

assessment i s not being conducted for difenoconazole.

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 9 of 21 Table 3. Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk

Assessments.
Exposure

Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD, for Risk

Asse ssment Study and Relevant Toxicological Effects
Acute Dietary (All populations) NOAEL =

25 mg/kg UF A 

### = 10X

UF H 

### = 10X FQPA SF = 1X aRfD = aPAD = 0.25

mg/kg/day Acute Neurotoxicity Study

in Rats LOAEL= 200 mg/kg in

males based on reduced

fore

- limb grip str ength in males on day 1.

Chronic Dietary (All populations) NOAEL =

0.96 mg/kg/day UF A 

### = 10X

UF H 

### = 10X FQPA SF = 1X cRfD = cPAD =

0.01mg/kg/day Combined chronic toxicity/carcinogenicity (rat; dietary) LOAEL = 24.1 /32.8 mg/kg/day (M/F)

based on cumulative

d ecreases in body

- weight gains

. Cancer (oral, dermal, inhalation) Difenoconazole is classified as a Group C, possible human carcinogen with a non

- linear (MOE)

approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated March 3, 2007, HED Doc. No. 0054532) . The chronic dietary exposure assessment is protective of

cancer effects. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrap olation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human ( int er sp ecies ). UF H 

### = potential variation in sensitivity among members of the human population ( int ra species ). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference do se.



## V I . Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the

DEEM

- FCID (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggre gate (food + water) analyses were performed using DEEM

- FCID

estimat ing the dietary exposure of the U.S. population and various population subgroups. The

results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively

.

The re sulting acute food exposure estimates were less than HED’s level of concern ( <100 % aPAD) at the 95 th 

## percentile of the exposure distribution for general US population ( 12 % aPAD) and all population sub

- groups; the most highly exposed population subgroup w as Children 1

- 2 years old with 2 7 % aPAD. The resulting chronic food exposure estimates were less than HED’s level of concern ( <100 % cPAD) for the general U

. S

. population ( 30 % cPAD) and all population

sub

- groups; the most highly exposed population subgr oup was children 1

- 2 years old with 7 5 %

cPAD. A separate cancer dietary assessment was not conducted for difenoconazole because the cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is

considered protective of all chronic effects including carcinogenicity

.

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 10 of 21 Table 4

. Summary of A cute Dietary (Food plus Water) Exposure and Risk for Difenoconazole at the 95 th



### Percentile.

Population Subgroup aPAD (mg/kg/day) Exposure (mg/kg/day) % a PAD

General U.S. Populatio n

0.25 0.0 30 3 85 12

All Infants (< 1 year old) 0. 0 56 767 23

Children 1

- 2 years old 0. 0 66 505 2 7

Children 3

- 5 years old 0.0 5 30 81 21

Children 6

- 12 years old 0.0 3 43 95 14

Youth 13

- 19 years old 0.0 23 7 87 10

Adults 20

- 49 years old 0.0 2 2 6 87 9

Adults 50+ years old 0.0 25 302 10

Females 13

- 49 years old 0.0 22 7 29 9

The bolded %aPAD is the highest.



### Table 5

. Summary of Chronic Dietary (Food plus Water) Exposure and Risk for Difenoconazole.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD

General U.S. Population

0.01 0.00 2 9 87 30

All Infants (< 1 year old) 0.00 4 701 4 7

Children 1

- 2 years old 0.00 7 4 60 7 5

Children 3

- 5 years old 0.00 62 42 62

Children 6

- 12 years old 0.00 3 903 3 9

Youth 13

- 19 ye ars old 0.00 2 5 74 2 6

Adults 20

- 49 years old 0.00 2 3 82 2 4

Adults 50+ years old 0.00 2 5 94 2 6

Females 13

- 49 years old 0.00 2 304 2 3

The bolded %cPAD is the highest.



## VI I . Characterization of Inputs/Outputs

The acute analys i s assumed toleran ce

- level residues, 100% CT, and empirical or DEEM default processing factors

. The chronic analysis assumed tolerance

- level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT , and empirical or DEEM defa ult processing factors

. Therefore, these analyses are considered

conservative

. While they could be significantly refined, further refinement is not warranted as

estimated risks are not of concern.

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 11 of 21 VII I . Conclusions

An a cute aggregate (food + w ater) dietary risk assessment was conducted for difenoconazole using the DEEM

- FCID (ver. 2.03) M odel and assumed tolerance

- level residues, 100% CT, and empirical or DEEM default processing factors

. The chronic aggregate dietary risk assessment

assumed t olerance

- level residues for some commodities, average field trial residues for the majority of commodities, 1 00 % CT , and empirical or DEEM default processing factors

. The resulting acute and chronic aggregate exposure estimate s w ere less than HED’s leve l of concern

. For the general U.S. population, the aPAD and cPAD were 12 % and 30 %, respectively. The most highly

- exposed population subgroups in the acute ( at the 95 th 

## percentile of the exposure distribution) and chronic analyses were Children 1

- 2 year s old ( 27 % aPAD) and children 1

- 2 years old ( 7 5 % cPAD)

, respectively.

IX . Attachments

Attachment 1 : DEEM

- FCID Acute Residue File

Attachment 2 : DEEM

- FCID Acute Exposure Estimates

Attachment 3 : DEEM

- FCID Chronic Residue File

Attachment 4 : DE EM

- FCID Chronic Exposure Estimates

c c with all attachments: T

. Morton (RAB IV )

RDI: A

. Acierto and M. Sahafeyan

- DESAC ( 26

- January

- 20 1 2 ) ; S. Hummel ( 30

- Ma y

- 201 2 ) Petition Number(s): 1E7852

DP#: 389652

PC Code: 128847

T

. Morton :S10 838 :PY1:(703)305

- 6691

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 12 of 21 Attachment 1 : DEEM

- FCID Acute Residue File

Filename: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 128847 Difenoconazole

1E7852 Jan 2012 \ difenoconazole_acute

- 01

- 12 wheat barley at tolerance.R98

Chemical: Difenoconazole RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 02

- 07

- 2012/12:32:14/8 Program ver. 2.03

----------------------------------------------------------------------- --------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01010520 1A Beet, sugar 0.300000 1.000 1.000 01010521 1A Beet, sugar

- babyfood 0.300000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 01010531 1A Beet, sugar, molasses

- baby food 0.300000 0.600 1.000

01010780 1AB Carrot 0.500000 1.000 1.000

01010781 1AB Carrot

- babyfood 0.500000 1.000 1.000 01010790 1AB Carrot, juice 0.500000 1.000 1.00 0 01030150 1CD Arrowroot, flour 4.000000 1.000 1.000 01030151 1CD Arrowroot, flour

- babyfood 4.000000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 4.000000 1.000 1.000

01030820 1CD Cassava 4.000000 1.000 1.000

01030821 1CD Cassava

- babyfood 4.000000 1.000 1.000 01031390 1CD Dasheen, corm 4.000000 1.000 1.000 01031660 1CD Ginger 4.000000 1.000 1.000 01031661 1CD Ginger

- babyfood 4.000000 1.000 1.000 01031670 1CD Ginger, dried 4.000000 1.000 1.000 01032960 1C Potato, chips 4.000000 0.500 1.000

01032970 1C Potato, dry (granules/ flakes) 4.000000 0.500 1.000 01032971 1C Potato, dry (granules/ flakes)

- b 4.000000 0.500 1.000 01032980 1C Potato, flour 4.000000 0.500 1.000 01032981 1C Potato, flour

- babyfood 4.000000 0.500 1.000 01032990 1C Potato, tuber, w/peel 4.000000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 4.000000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 4.000000 1.000 1.000

0 1033001 1C Potato, tuber, w/o peel

- babyfood 4.000000 1.000 1.000 01033660 1CD Sweet potato 4.000000 1.000 1.000 01033661 1CD Sweet potato

- babyfood 4.000000 1.000 1.000 01033710 1CD Tanier, corm 4.000000 1.000 1.000

01033870 1CD Turmeric 4.000000 1.000 1.000 01034060 1CD Yam, true 4.000000 1.000 1.000

01034070 1CD Yam bean 4.000000 1.0 00 1.000

03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried

- babyfood 0.200000 1.000 1.000

03001980 3 Leek 6.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb

- babyfood 0.200000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0 .200000 9.000 1.000 03002381 3 Onion, dry bulb, dried

- babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 6.000000 1.000 1.000

03003380 3 Shallot 0.200000 1.000 1.000

050106 10 5A Broccoli 1.900000 1.000 1.000

05010611 5A Broccoli

- babyfood 1.900000 1.000 1.000 05010620 5A Broccoli, Chinese 1.900000 1.000 1.000 05010640 5A Brussels sprouts 1.900000 1.000 1.000 05010690 5A Cabbage 1.900000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 1.900000 1.000 1 .000

05010830 5A Cauliflower 1.900000 1.000 1.000

05011960 5A Kohlrabi 1.900000 1.000 1.000

05020630 5B Broccoli raab 35.000000 1.000 1.000 05020700 5B Cabbage, C hinese, bok choy 35.000000 1.000 1.000

05021170 5B Collards 35.000000 1.000 1.000

05021940 5B Kale 35.000000 1.000 1.000 05022290 5B Mustard greens 35.0000 00 1.000 1.000 05023180 5B Rape greens 35.000000 1.000 1.000 05023890 5B Turnip, greens 35.000000 1.000 1.000 06003470 6 Soybean, seed 0.150000 1.000 1.000

06003480 6 Soybean, flour 0.150000 1.000 1.000 06003481 6 Soybean, flour

- babyfood 0.150000 1.000 1.000 06003490 6 Soybean, soy milk 0.150000 1.000 1.000 06003491 6 Soybean, soy milk

- babyfood o r in 0.150000 1.000 1.000 06003500 6 Soybean, oil 0.150000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

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## 13 of 21 06003501 6 Soybean, oil

- babyfood 0.150000 1.000 1.000 06030980 6C Chickpea, seed 0.080000 1.000 1.000 06030981 6C Chickpea, seed

- babyfood 0.080000 1.000 1.000 06030990 6C Chickpea, flour 0.080000 1.000 1.000 08001480 8 Eggplant 0.600000 1.000 1.000

08002340 8 Okra 0.600000 1.000 1.000 08002700 8 Pepper, bell 0.600000 1.000 1.000 08002701 8 Pepper, bell

- babyfood 0.600000 1.000 1.000 08002710 8 Pepper, bell, dried 0.600000 1.000 1.000 08002711 8 Pepper, bell, dried

- babyfood 0.600000 1.000 1.000 08002720 8 Pepper, nonbell 0.600000 1.000 1.000 08002721 8 Pepper, nonbell

- babyfood 0.600000 1.000 1.000

08002730 8 Pe pper, nonbell, dried 0.600000 1.000 1.000

08003740 8 Tomatillo 0.600000 1.000 1.000

08003750 8 Tomato 0.600000 1.000 1.000

08003751 8 Tomato

- babyfood 0.600000 1.000 1.000 08003760 8 Tomato, paste 0.600000 1.600 1.000 08003761 8 Tomato, paste

- babyfood 0.600000 1.600 1.000 08003770 8 Tomato, puree 0.600000 0.500 1.000

080 03771 8 Tomato, puree

- babyfood 0.600000 0.500 1.000 08003780 8 Tomato, dried 0.600000 14.300 1.000 08003781 8 Tomato, dried

- babyfood 0.600000 14.300 1.000 08003790 8 Tomato, juice 0.600000 1.500 1.000 09010750 9A Cantaloupe 0.700000 1.000 1.000

09010800 9A Casaba 0.700000 1.000 1.000 09011870 9A Honeydew melon 0.700000 1.000 1.000

09013990 9A Watermelon 0.700000 1.000 1.000 09014000 9A Watermelon, juice 0.700000 1.000 1.000 09020210 9B Balsam pear 0.700000 1.000 1.000 09020880 9B Chayote , fruit 0.700000 1.000 1.000 09021020 9B Chinese waxgourd 0.700000 1.000 1.000

09021350 9B Cucumber 0.700000 1.000 1.000 09023080 9B Pumpkin 0.7 00000 1.000 1.000 09023090 9B Pumpkin, seed 0.700000 1.000 1.000 09023560 9B Squash, summer 0.700000 1.000 1.000 09023561 9B Squash, summer

- babyfood 0.700000 1.000 1.000

09023570 9B Squash, winter 0.700000 1.000 1.000 09023571 9B Squash, winter

- babyfood 0.700000 1.000 1.000

10001060 10 Citrus citron 0.600000 1.000 1.000 10001070 10 Citrus hybrids 0.600000 1.000 1.000 10001080 10 Citrus, oil 25.000000 1.000 1.000 10001800 10 Grapefruit 0.600000 1.000 1.000 10001810 10 Grapefruit, juice 0.600000 0.100 1.0 00 10001970 10 Kumquat 0.600000 1.000 1.000

10001990 10 Lemon 0.600000 1.000 1.000 10002000 10 Lemon, juice 0.600000 0.100 1.000 10002001 10 Lemon, juice

- babyfood 0.600000 0.100 1.000 10002010 10 Lemon, peel 0.600000 1.000 1.000

10002060 10 Lime 0.600000 1.000 1.000 10002070 10 Lime, juice 0.600000 0.100 1.000 10002071 10 Lime, juice

- babyfood 0.600000 0.100 1.000 10002400 10 Orange 0.600000 1.000 1.000 10002410 10 Orange, juice 0.600000 0.100 1.000

10002411 10 Orange, juice

- babyfood 0.600000 0.100 1.000 10002420 10 Orange, peel 0.600000 1.000 1.000

10003070 10 Pummelo 0.600000 1.000 1.000 10003690 10 Tangerine 0.600000 1.000 1.000 10003700 10 Tangerine, juice 0.600000 0.100 1.000 11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 11000081 11 Apple, peeled fruit

- babyfood 1.000000 1.000 1.000 11000090 11 Apple, dried 1.000000 8.000 1.000 11000091 11 Apple, dried

- babyfood 1.000000 8.000 1.000 11000100 11 Apple, juice 1.000000 0.040 1.000 11000101 11 Apple, juice

- babyfood 1.000000 0.040 1.000 11000110 11 Apple, sauce 1.000000 1.000 1.000 11000111 11 Apple, sauce

- babyfood 1.000000 1. 000 1.000 11001290 11 Crabapple 1.000000 1.000 1.000 11002100 11 Loquat 1.000000 1.000 1.000

11002660 11 Pear 1.000000 1.000 1.000

11002661 11 Pear

- babyfood 1.000000 1.000 1.000 11002670 11 Pear, dried 1.000000 6.250 1.000 11002680 11 Pear, juice 1.000000 1.000 1.000 11002681 11 Pear, juice

- babyfood 1.000000 1.000 1.000 11003100 11 Quince 1.000000 1.000 1.000 12000120 12 Apricot 2.500000 1.000 1.000 12000121 12 Apricot

- babyfood 2.500000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 14 of 21 12000 130 12 Apricot, dried 2.500000 1.000 1.000 12000140 12 Apricot, juice 2.500000 1.000 1.000 12000141 12 Apricot, juice

- babyfood 2.500000 1.000 1.000 12000900 12 Cherry 2.500000 1.000 1.000 12000901 12 Cherry

- babyfood 2.500000 1.000 1.000 12000910 12 Cherry, juice 2.500000 1.000 1.000 12000911 12 Cherry, juice

- babyfood 2.500000 1.000 1.000

12002300 12 Nectarine 2.500000 1.000 1.000

12002600 12 Peach 2.500000 1.000 1.000

12002601 12 Peach

- babyfood 2.500000 1.000 1.000 12002610 12 Peach, dr ied 2.500000 1.000 1.000 12002611 12 Peach, dried

- babyfood 2.500000 1.000 1.000 12002620 12 Peach, juice 2.500000 1.000 1.000 12002621 12 Peach, juice

- babyfood 2.500 000 1.000 1.000

12002850 12 Plum 2.500000 1.000 1.000

12002851 12 Plum

- babyfood 2.500000 1.000 1.000 12002860 12 Plum, prune, fresh 2.500000 1.000 1.000

12002861 1 2 Plum, prune, fresh

- babyfood 2.500000 1.000 1.000 12002870 12 Plum, prune, dried 2.500000 1.000 1.000 12002871 12 Plum, prune, dried

- babyfood 2.500000 1.000 1.000 12002880 12 Plum, prune, juice 2.500000 1.000 1.000 12002881 12 Plum, prune, juice

- babyfood 2.500000 1.000 1.000 13020570 13B Blueberry 2.500000 1.000 1.000 13020571 13B Blueberry

- babyfood 2.500000 1.000 1.000

14000030 14 Almond 0.030000 1.000 1.000

14000031 14 Almond

- babyfood 0.030000 1.000 1.000 14000040 14 Almond, oil 0.030000 1.000 1.000 14000041 14 Almond, oil

- ba byfood 0.030000 1.000 1.000

14000590 14 Brazil nut 0.030000 1.000 1.000

14000680 14 Butternut 0.030000 1.000 1.000

14000810 14 Cashew 0.030000 1.000 1.000

14000920 14 Chestnut 0.030000 1.000 1.000

14001550 14 Filbert 0.030000 1.000 1.000 14001560 14 Filbert, oil 0.030000 1.000 1.000

14001850 14 H ickory nut 0.030000 1.000 1.000

14002130 14 Macadamia nut 0.030000 1.000 1.000

14002690 14 Pecan 0.030000 1.000 1.000

14002820 14 Pistachio 0.030000 1.000 1.000

14003910 14 Walnut 0.030000 1.000 1.000 15000250 15 Barley, pearled barley 0.100000 1.000 1.000 15000251 15 Barley, pearled barley

- babyfood 0.100000 1.000 1.000

15 000260 15 Barley, flour 0.100000 1.000 1.000 15000261 15 Barley, flour

- babyfood 0.100000 1.000 1.000 15000270 15 Barley, bran 0.100000 1.000 1.000 15001270 15 Corn, sweet 0.010000 1.000 1.000 15001271 15 Corn, sweet

- babyfood 0.010000 1.000 1.000 15002310 15 Oat, bran 0.010000 1.000 1.000 15002320 15 Oat, flour 0.010000 1.00 0 1.000 15002321 15 Oat, flour

- babyfood 0.010000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.010000 1.000 1.000 15002331 15 Oat, groats/rolled oats

- babyfood 0.010000 1.000 1.000 15003280 15 Rye, g rain 0.010000 1.000 1.000 15003290 15 Rye, flour 0.010000 1.000 1.000 15004010 15 Wheat, grain 0.100000 1.000 1.000 15004011 15 Wheat, grain

- babyfood 0. 100000 1.000 1.000 15004020 15 Wheat, flour 0.100000 1.000 1.000 15004021 15 Wheat, flour

- babyfood 0.100000 1.000 1.000 15004030 15 Wheat, germ 0.100000 1.000 1.000

1500404 0 15 Wheat, bran 0.100000 1.000 1.000 20003190 20 Rapeseed, oil 0.010000 1.000 1.000 20003191 20 Rapeseed, oil

- babyfood 0.010000 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat

- babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.100000 1.000 1. 000 21000461 M Beef, meat byproducts

- babyfood 0.100000 1.000 1.000 21000470 M Beef, fat 0.100000 1.000 1.000 21000471 M Beef,fat

- babyfood 0.100000 1.000 1.000 21000480 M Beef, kidne y 0.100000 1.000 1.000 21000490 M Beef, liver 0.400000 1.000 1.000 21000491 M Beef, liver

- babyfood 0.400000 1.000 1.000 23001690 M Goat, meat 0.05000 0 1.000 1.000 23001700 M Goat, meat byproducts 0.100000 1.000 1.000 23001710 M Goat, fat 0.100000 1.000 1.000 23001720 M Goat, kidney 0.100000 1.000 1.000

23001730 M Goat, liver 0.400000 1.000 1.000 24001890 M Horse, meat 0.050000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 15 of 21 25002900 M Pork, meat 0.050000 1.000 1.000 25002901 M Pork, meat

- babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.100000 1.000 1.000 25002920 M Pork, meat byproducts 0.100000 1.000 1.000 25002921 M Pork, meat byproducts

- babyfood 0.100000 1.000 1.000 25002930 M Pork, fat 0.100000 1.000 1.000 25002931 M Pork, fat

- babyfood 0.100000 1.000 1.000 25002940 M Pork, kidney 0.100000 1.000 1.000 25002950 M Pork, liver 0.400000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat

- babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.100000 1 .000 1.000 26003410 M Sheep, fat 0.100000 1.000 1.000 26003411 M Sheep, fat

- babyfood 0.100000 1.000 1.000 26003420 M Sheep, kidney 0.100000 1.000 1.000

26003430 M She ep, liver 0.400000 1.000 1.000 27002220 D Milk, fat 0.015000 1.000 1.000 27002221 D Milk, fat

- baby food/infant for 0.015000 1.000 1.000 27012230 D Milk, nonfat solids 0.015000 1.000 1.000 27012231 D Milk, nonfat solids

- baby food/in 0.015000 1.000 1.000 27022240 D Milk, water 0.015000 1.000 1.000 27022241 D Milk, water

- babyfood/infant form 0.015000 1.000 1.000

2703 2251 D Milk, sugar (lactose)

- baby food/ 0.015000 1.000 1.000 70001450 P Egg, whole 0.020000 1.000 1.000 70001451 P Egg, whole

- babyfood 0.020000 1.000 1.000 70001460 P Egg, white 0.020000 1.000 1.000 70001461 P Egg, white (solids)

- babyfood 0.020000 1.000 1.000 70001470 P Egg, yolk 0.020000 1.000 1.000 70001471 P Egg, yolk

- babyfood 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.017400 1.000 1.000 86020000 O Water, indirect, all sources 0.017400 1.000 1.000

95000230 O Banana 0.200000 1.000 1.000

95000231 O Banana

- b abyfood 0.200000 1.000 1.000 95000240 O Banana, dried 0.200000 3.900 1.000 95000241 O Banana, dried

- babyfood 0.200000 3.900 1.000 95001280 O Cottonseed, oil 0.05 0000 1.000 1.000 95001281 O Cottonseed, oil

- babyfood 0.050000 1.000 1.000 95001750 O Grape 4.000000 1.000 1.000 95001760 O Grape, juice 4.000000 0.200 1.000

95001761 O Grape, juice

- babyfood 4.000000 0.200 1.000 95001770 O Grape, leaves 4.000000 1.000 1.000 95001780 O Grape, raisin 6.000000 1.000 1.000 95001790 O Grape, wine and sherry 4.000000 1.000 1.000 95002150 O Mango 0.070000 1.000 1.000 95002151 O Mango

- babyfood 0.070000 1.000 1.000 95002160 O Mango, dried 0.070000 1.000 1.00 0 95002170 O Mango, juice 0.070000 1.000 1.000 95002171 O Mango, juice

- babyfood 0.070000 1.000 1.000 95002450 O Papaya 0.300000 1.000 1.000 95002451 O Papaya

- babyfo od 0.300000 1.000 1.000 95002460 O Papaya, dried 0.300000 1.800 1.000 95002470 O Papaya, juice 0.300000 1.500 1.000

95002830 O Plantain 0.200000 1.000 1.000 95002840 O Plantain, dried 0.200000 3.900 1.000 95003590 O Strawberry 2.500000 1.000 1.000 95003591 O Strawberry

- babyfood 2.500000 1.000 1.000

95003600 O Strawberry, juice 2.500000 1.000 1.000 95003601 O Strawberry, juice

- babyfood 2.500000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 16 of 21 Attachment 2 : DEEM

- FCID Acute Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.02

DEEM

- FCID ACUTE Analysis for DIFENOCONAZOLE (1994

- 98 data) Residue file: difenoconazole_acute

- 01

- 12 wheat barley at tolerance.R98 Adjustment factor #2 used. Analysis Date: 02

- 22

- 2012/13:40:53 Residue fil e dated: 02

- 22

- 2012/13:38:41/8 Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population:

0.030385 12.15 0.067004 26.80 0.154531 61.81

All infants:

0.056767 22.71 0.094429 37.77 0.140489 56.20

Children 1

- 2 yrs:

0.066505 26.60 0.110223 44.09 0.262525 105.01

Children 3

- 5 yrs:

0.053081 21.23 0.097507 39.00 0.381012 152.40

Children 6

- 12 yrs:

0.034395 13.76 0.059641 23.86 0.148121 59.25

Youth 13

- 19 yrs:

0.023787 9.51 0.052679 21.07 0.138411 55.36

Adults 20

- 49 yrs:

0.022687 9.07 0.048712 19.48 0.116353 46.54 Adults 50+ yrs:

0.025302 10.12 0.067231 26.89 0.149167 59.67

Females 13

- 49 yrs:

0.022729 9.09 0.048698 19.48 0.121607 48.64

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 17 of 21 Attachment 3 : DEEM

- FCID Chronic Residue File

Filename: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 128847 Difenoconazole

1E7852 Jan 2012 \ difenoconazole_chronic

- 01

- 12Avera geFT wheat barley at tolerance.R98

Chemical: Difenoconazole RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 02

- 07

- 2012/12:33:37/8 Program ver. 2.0 3

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ---- --------------------------- ---------- ------ ------ ------- 01010520 1A Beet, sugar 0.300000 1.000 1.000 01010521 1A Beet, sugar

- babyfood 0.300000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 01010531 1A Beet, sugar, molasses

- babyfood 0.300000 0.600 1.000

01010780 1AB Carrot 0.062000 1.000 1.000

01010781 1AB Carrot

- babyfood 0.062000 1.000 1.000 01010790 1AB Carrot, juice 0.062000 1.000 1.000 01030150 1CD Arrowroot, flour 1.360000 1.000 1.000 01030151 1CD Arrowroot, flour

- babyfood 1.360000 1.000 1.000 01030170 1CD Artichoke, Jeru salem 1.360000 1.000 1.000

01030820 1CD Cassava 1.360000 1.000 1.000

01030821 1CD Cassava

- babyfood 1.360000 1.000 1.000 01031390 1CD Dasheen, corm 1.360000 1.000 1.000 01031660 1CD Ginger 1.360000 1.000 1.000 01031661 1CD Ginger

- babyfood 1.360000 1.000 1.000 01031670 1CD Ginger, dried 1.360000 1.000 1.000

01032960 1C Po tato, chips 1.360000 0.500 1.000 01032970 1C Potato, dry (granules/ flakes) 1.360000 0.500 1.000 01032971 1C Potato, dry (granules/ flakes)

- b 1.360000 0.500 1.000 01032980 1C Potato, flour 1.360000 0.500 1.000 01032981 1C Potato, flour

- babyfood 1.360000 0.500 1.000 01032990 1C Potato, tuber, w/peel 1.360000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 1.360000 1.000 1.000

010 33000 1C Potato, tuber, w/o peel 1.360000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 1.360000 1.000 1.000 01033660 1CD Sweet potato 1.360000 1.000 1.000 01033661 1CD Sweet potato

- babyfoo d 1.360000 1.000 1.000 01033710 1CD Tanier, corm 1.360000 1.000 1.000

01033870 1CD Turmeric 1.360000 1.000 1.000 01034060 1CD Yam, true 1.360000 1.000 1.000

01034070 1CD Yam bean 1.360000 1.000 1.000

03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried

- babyfood 0.200000 1.000 1.000

03001980 3 Leek 6.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb

- babyfood 0.2 00000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 03002381 3 Onion, dry bulb, dried

- babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 6.000000 1.000 1.000

03003380 3 Shallot 0.200000 1.000 1.000

05010610 5A Broccoli 0.221000 1.000 1.000

05010611 5A Broccoli

- babyfood 0.221000 1.000 1.000 05010620 5A Broccoli, Chinese 0.221000 1.000 1.000 05010640 5A Brussels sprouts 0.029000 1.000 1.000 05010690 5A Cabbage 0.029000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 0.029000 1.000 1.0 00 05010720 5A Cabbage, Chinese, mustard 0.221000 1.000 1.000

05010830 5A Cauliflower 0.221000 1.000 1.000

05011960 5A Kohlrabi 0.029000 1.000 1.000

05020630 5B Broccoli raa b 5.100000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 5.100000 1.000 1.000

05021170 5B Collards 5.100000 1.000 1.000

05021940 5B Kale 5.100000 1.000 1.000 05022290 5B Mustard greens 5.100000 1.000 1.000 05023180 5B Rape greens 5.100000 1.000 1.000 05023890 5B Turnip, greens 5.100000 1.000 1.000

06003470 6 Soybean, seed 0.021500 1.000 1.000 06003480 6 Soybean, flour 0.021500 1.000 1.000 06003481 6 Soybean, flour

- babyfood 0.021500 1.000 1.000 06003490 6 Soybean, soy milk 0.021500 1.000 1.000 06003491 6 Soybean, soy milk

- babyfood or in 0.021500 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 18 of 21 06003500 6 Soybean, oil 0.021500 1.000 1.000 06003501 6 Soybean, oil

- babyfood 0.021500 1.000 1.000 06030980 6C Chickpea, seed 0.017000 1.000 1.000 06030981 6C Chickpea, seed

- babyfood 0.017000 1.000 1.000 06030990 6C Chickpea, flour 0.017000 1.000 1.000 08001480 8 Eggplant 0.133000 1.000 1.000

08002340 8 Okra 0.600000 1.000 1.000 08002700 8 Pepper, bell 0.133000 1.000 1.000 08002701 8 Pepper, bell

- babyfood 0.133000 1. 000 1.000 08002710 8 Pepper, bell, dried 0.133000 1.000 1.000 08002711 8 Pepper, bell, dried

- babyfood 0.133000 1.000 1.000 08002720 8 Pepper, nonbell 0.133000 1.000 1.000 08002721 8 Pepp er, nonbell

- babyfood 0.133000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.133000 1.000 1.000

08003740 8 Tomatillo 0.165000 1.000 1.000

08003750 8 Tomato 0.165000 1.000 1.000

08003751 8 Tomato

- babyfood 0.165000 1.000 1.000 08003760 8 Tomato, paste 0.165000 1.600 1.000 08003761 8 Tomato, paste

- babyfood 0.165000 1.600 1.000

08003 770 8 Tomato, puree 0.165000 0.500 1.000 08003771 8 Tomato, puree

- babyfood 0.165000 0.500 1.000 08003780 8 Tomato, dried 0.165000 14.300 1.000 08003781 8 Tomato, dried

- babyfood 0.165000 14.300 1.000 08003790 8 Tomato, juice 0.165000 1.500 1.000 09010750 9A Cantaloupe 0.137000 1.000 1.000

09010800 9A Casaba 0.137000 1.000 1.000 09011870 9A Honeydew melon 0.137000 1.000 1.000

09013990 9A Watermelon 0.137000 1.000 1.000 09014000 9A Watermelon, juice 0.137000 1.000 1.000 09020210 9B Balsam pe ar 0.055000 1.000 1.000 09020880 9B Chayote, fruit 0.310000 1.000 1.000 09021020 9B Chinese waxgourd 0.055000 1.000 1.000

09021350 9B Cucumber 0.055 000 1.000 1.000 09023080 9B Pumpkin 0.031000 1.000 1.000 09023090 9B Pumpkin, seed 0.031000 1.000 1.000 09023560 9B Squash, summer 0.031000 1.000 1.000

09023561 9 B Squash, summer

- babyfood 0.031000 1.000 1.000 09023570 9B Squash, winter 0.031000 1.000 1.000 09023571 9B Squash, winter

- babyfood 0.031000 1.000 1.000

10001060 10 Citrus citron 0.208000 1.000 1.000 10001070 10 Citrus hybrids 0.208000 1.000 1.000 10001080 10 Citrus, oil 25.000000 1.000 1.000 10001800 10 Grapefruit 0.120000 1.000 1.000 10001810 10 Grapefruit, juice 0.120000 0.100 1.000 10001970 10 Kumquat 0.208000 1.000 1.000

10001990 10 Lemon 0.176000 1.000 1.000 10002000 10 Lemon, juice 0.176000 0.100 1.000 10002001 10 Lemon, juice

- babyfood 0.176000 0.100 1.000 10002010 10 Lemon, peel 0.176000 1.000 1.000

10002060 10 Lime 0.176000 1.000 1.000 10002070 10 Lime, juice 0.176000 0.100 1.000 10002071 10 Lime, juice

- babyfood 0.176000 0.100 1.000 10002400 10 Orange 0.208000 1.000 1.000

10002410 10 O range, juice 0.208000 0.100 1.000 10002411 10 Orange, juice

- babyfood 0.208000 0.100 1.000 10002420 10 Orange, peel 0.208000 1.000 1.000

10003070 10 Pummelo 0.120000 1.000 1.000 10003690 10 Tangerine 0.208000 1.000 1.000 10003700 10 Tangerine, juice 0.208000 0.100 1.000 11000070 11 Apple, fruit with peel 0.203000 1.000 1.000

11 000080 11 Apple, peeled fruit 0.203000 1.000 1.000 11000081 11 Apple, peeled fruit

- babyfood 0.203000 1.000 1.000 11000090 11 Apple, dried 0.203000 8.000 1.000 11000091 11 Apple, dried

- babyfo od 0.203000 8.000 1.000 11000100 11 Apple, juice 0.203000 0.040 1.000 11000101 11 Apple, juice

- babyfood 0.203000 0.040 1.000 11000110 11 Apple, sauce 0.203000 1.00 0 1.000 11000111 11 Apple, sauce

- babyfood 0.203000 1.000 1.000 11001290 11 Crabapple 0.203000 1.000 1.000 11002100 11 Loquat 0.123000 1.000 1.000

11002660 11 Pear 0.123000 1.000 1.000

11002661 11 Pear

- babyfood 0.123000 1.000 1.000 11002670 11 Pear, dried 0.123000 6.250 1.000 11002680 11 Pear, juice 0. 123000 1.000 1.000 11002681 11 Pear, juice

- babyfood 0.123000 1.000 1.000 11003100 11 Quince 0.123000 1.000 1.000 12000120 12 Apricot 0.421000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 19 of 21 1200012 1 12 Apricot

- babyfood 0.421000 1.000 1.000 12000130 12 Apricot, dried 0.421000 1.000 1.000 12000140 12 Apricot, juice 0.421000 1.000 1.000 12000141 12 Apricot, juice

- babyfood 0.421000 1.000 1.000 12000900 12 Cherry 0.622000 1.000 1.000 12000901 12 Cherry

- babyfood 0.622000 1.000 1.000 12000910 12 Cherry, juice 0.622000 1.000 1. 000 12000911 12 Cherry, juice

- babyfood 0.622000 1.000 1.000

12002300 12 Nectarine 0.421000 1.000 1.000

12002600 12 Peach 0.421000 1.000 1.000

12002601 12 Peach

- babyf ood 0.421000 1.000 1.000 12002610 12 Peach, dried 0.421000 1.000 1.000 12002611 12 Peach, dried

- babyfood 0.421000 1.000 1.000 12002620 12 Peach, juice 0.42100 0 1.000 1.000 12002621 12 Peach, juice

- babyfood 0.421000 1.000 1.000

12002850 12 Plum 0.295000 1.000 1.000

12002851 12 Plum

- babyfood 0.295000 1.000 1.000

12002860 12 Plum, prune, fresh 0.295000 1.000 1.000 12002861 12 Plum, prune, fresh

- babyfood 0.295000 1.000 1.000 12002870 12 Plum, prune, dried 0.295000 2.600 1.000 12002871 12 Plum, prune, dried

- babyfood 0.295000 2.600 1.000 12002880 12 Plum, prune, juice 0.295000 1.000 1.000 12002881 12 Plum, prune, juice

- babyfood 0.295000 1.000 1.000 13020570 13B Blueberry 0.495000 1.000 1.000 13020571 13B Blueberry

- babyfood 0.495000 1.000 1.000

14000030 14 Almond 0.005000 1.000 1.000

14000031 14 Almond

- babyfood 0.005000 1.000 1.000 14000040 14 Almond, oil 0.005000 1.000 1.000 14000041 14 Almond, oil

- babyfood 0.005000 1.000 1.000

14000590 14 Brazil nut 0.007000 1.000 1.000

14000680 14 Butternut 0.007000 1 .000 1.000

14000810 14 Cashew 0.007000 1.000 1.000

14000920 14 Chestnut 0.005000 1.000 1.000

14001550 14 Filbert 0.007000 1.000 1.000

14001560 14 Fil bert, oil 0.007000 1.000 1.000 14001850 14 Hickory nut 0.007000 1.000 1.000

14002130 14 Macadamia nut 0.007000 1.000 1.000

14002690 14 Pecan 0.007000 1.000 1.000

14002820 14 Pistachio 0.005000 1.000 1.000

14003910 14 Walnut 0.007000 1.000 1.000 15000250 15 Barley, pearled barley 0.100000 1.000 1.000

1500 0251 15 Barley, pearled barley

- babyfood 0.100000 1.000 1.000 15000260 15 Barley, flour 0.100000 1.000 1.000 15000261 15 Barley, flour

- babyfood 0.100000 1.000 1.000 15000270 15 Barley, bran 0.100000 1.000 1.000 15001270 15 Corn, sweet 0.010000 1.000 1.000 15001271 15 Corn, sweet

- babyfood 0.010000 1.000 1.000 15002310 15 Oat, bran 0.010000 1.000 1.000 15002320 15 Oat, flour 0.010000 1.000 1.000 15002321 15 Oat, flour

- babyfood 0.010000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.010000 1.000 1.000 15002331 15 Oat, gro ats/rolled oats

- babyfood 0.010000 1.000 1.000 15003280 15 Rye, grain 0.010000 1.000 1.000 15003290 15 Rye, flour 0.010000 1.000 1.000 15004010 15 Wheat, grain 0.10 0000 1.000 1.000 15004011 15 Wheat, grain

- babyfood 0.100000 1.000 1.000 15004020 15 Wheat, flour 0.100000 1.000 1.000 15004021 15 Wheat, flour

- babyfood 0.100000 1.000 1.000

15004030 15 Wheat, germ 0.100000 1.000 1.000 15004040 15 Wheat, bran 0.100000 1.000 1.000 20003190 20 Rapeseed, oil 0.010000 1.000 1.000 20003191 20 Rapeseed, oil

- babyfood 0.010000 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat

- babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.00 0 21000460 M Beef, meat byproducts 0.100000 1.000 1.000 21000461 M Beef, meat byproducts

- babyfood 0.100000 1.000 1.000 21000470 M Beef, fat 0.100000 1.000 1.000 21000471 M Beef,fat

- baby food 0.100000 1.000 1.000 21000480 M Beef, kidney 0.100000 1.000 1.000 21000490 M Beef, liver 0.400000 1.000 1.000 21000491 M Beef, liver

- babyfood 0.400000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.100000 1.000 1.000 23001710 M Goat, fat 0.100000 1.000 1.000

23001720 M Goat, kidney 0.100000 1.000 1.000 23001730 M Goat, liver 0.400000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 20 of 21 24001890 M Horse, meat 0.050000 1.000 1.000 25002900 M Pork, meat 0.050000 1.000 1.000 25002901 M Pork, meat

- babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.100000 1.000 1.000 25002920 M Pork, meat byproducts 0.100000 1.000 1.000

2 5002921 M Pork, meat byproducts

- babyfood 0.100000 1.000 1.000 25002930 M Pork, fat 0.100000 1.000 1.000 25002931 M Pork, fat

- babyfood 0.100000 1.000 1.000 25002940 M Pork, kidney 0.100000 1.000 1.000 25002950 M Pork, liver 0.400000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat

- babyfood 0.050000 1.0 00 1.000 26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 26003410 M Sheep, fat 0.100000 1.000 1.000 26003411 M Sheep, fat

- babyfood 0.100000 1.000 1.000 26003420 M Sheep , kidney 0.100000 1.000 1.000 26003430 M Sheep, liver 0.400000 1.000 1.000 27002220 D Milk, fat 0.010000 1.000 1.000 27002221 D Milk, fat

- baby food/infant for 0 .010000 1.000 1.000 27012230 D Milk, nonfat solids 0.010000 1.000 1.000 27012231 D Milk, nonfat solids

- baby food/in 0.010000 1.000 1.000 27022240 D Milk, water 0.010000 1.000 1.000

270222 41 D Milk, water

- babyfood/infant form 0.010000 1.000 1.000 27032251 D Milk, sugar (lactose)

- baby food/ 0.010000 1.000 1.000 70001450 P Egg, whole 0.020000 1.000 1.000 70001451 P Egg, whole

- babyfood 0.020000 1.000 1.000 70001460 P Egg, white 0.020000 1.000 1.000 70001461 P Egg, white (solids)

- babyfood 0.020000 1.000 1.000 70001470 P Egg, yolk 0.020000 1.000 1 .000 70001471 P Egg, yolk

- babyfood 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.011800 1.000 1.000 86020000 O Water, indirect, all sources 0.011800 1.000 1.000

95000230 O Banana 0.200000 1.000 1.000

95000231 O Banana

- babyfood 0.200000 1.000 1.000 95000240 O Banana, dried 0.200000 3.900 1.000 95000241 O Banana, dried

- babyfood 0.2000 00 3.900 1.000 95001280 O Cottonseed, oil 0.050000 1.000 1.000 95001281 O Cottonseed, oil

- babyfood 0.050000 1.000 1.000 95001750 O Grape 0.613000 1.000 1.000

95001760 O Grape, juice 0.613000 0.200 1.000 95001761 O Grape, juice

- babyfood 0.613000 0.200 1.000 95001770 O Grape, leaves 0.613000 1.000 1.000 95001780 O Grape, raisin 0.613000 3.500 1.000 95001790 O Grape, wine and sherry 0.613000 1.000 1.000 95002150 O Mango 0.070000 1.000 1.000 95002151 O Mango

- babyfood 0.070000 1.000 1.000 95002160 O Mango, dried 0.070000 1.000 1.000 95002170 O Mango, juice 0.070000 1.000 1.000 95002171 O Mango, juice

- babyfood 0.070000 1.000 1.000 95002450 O Papaya 0.300000 1.000 1.000 95002451 O Papaya

- babyfood 0.300000 1.000 1.000 95002460 O Papaya, dried 0.300000 1.800 1.000 95002470 O Papaya, juice 0.300000 1.500 1.000

95002830 O Plantain 0.200000 1.000 1.000 95002840 O Plantain, dried 0.200000 3.900 1.000 95003590 O Strawberry 0.495000 1.000 1.000

95003591 O St rawberry

- babyfood 0.495000 1.000 1.000 95003600 O Strawberry, juice 0.495000 1.000 1.000 95003601 O Strawberry, juice

- babyfood 0.495000 1.000 1.000

### Difenoconazole Dietary Exposure Assessment DP#: 3 97664

PC Code: 128847



## 21 of 21 Attachm ent 4 : DEEM

- FCID Chronic Exposure Es timates

U.S. Environmental Protection Agency Ver. 2.00

DEEM

- FCID Chronic analysis for DIFENOCONAZOLE (1994

- 98 data)

Residue file name: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 1288 47

Difenoconazole 1E7852 Jan 2012 \ difenoconazole_chronic

- 01

- 12AverageFT wheat barley at

tolerance.R98 Adjustment factor #2 used. Analysis Date 02

- 22

- 2012/13:42:37 Residue file dated: 02

- 22

- 2012/13:39 :12/8 Reference dose (RfD, Chronic) = .01 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

--------------------------------------------------------------- ----------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgro up body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.002987 29.9%

U.S. Population (spring season) 0.002974 29.7% U.S. Population (summer season) 0.003013 30.1% U.S. Population (autumn season) 0.003022 30.2% U.S. Population (winter season) 0.002935 29.3%

Nor theast region 0.002890 28.9% Midwest region 0.003081 30.8% Southern region 0.002911 29.1% Western region 0.003095 31.0%

Hispanics 0.003058 30.6%

Non

- hispanic whites 0.002892 28.9%

Non

- hispanic blacks 0.003214 32 .1%

Non

- hisp/non

- white/non

- black 0.003732 37.3%

All infants (< 1 year) 0.004701 47.0% Nursing infants 0.002496 25.0%

Non

- nursing infants 0.005539 55.4%

Children 1

- 6 yrs 0.006440 64.4%

Children 7

- 12 yrs 0.003708 37.1%

Females 13

- 19 (not preg or nursing) 0.002301 23.0% Females 20+ (not preg or nursing) 0.002402 24.0%

Females 13

- 50 yrs 0.002455 24.5% Females 13+ (preg/not nursing) 0.002384 23.8% Females 13+ (nursing) 0.002707 27.1%

Males 13

- 19 yrs 0.002844 28.4% Males 20+ yrs 0.002516 25.2%

Seniors 55+ 0.002645 26.4%

Children 1

- 2 yrs 0.007460 74.6%

Children 3

- 5 yrs 0.006242 62.4%

Children 6

- 12 yrs 0.003903 39.0%

Youth 13

- 19 yrs 0.002574 25.7%

Adults 20

- 49 yrs 0.002382 23.8% Adults 50+ yrs 0.002594 25.9%

Females 13

- 49 yrs 0.002304 23.0%

-------------------------------------------------------------------------------