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|   | 1. | The      above recitals are true in substance and in  fact. |
|--------|----|-------------------------------------------------------------|

|   | 2. | The      Lease shall be and is hereby amended asfollows: |
|--------|----|----------------------------------------------------------|

|   | (a) | Section      1(b) Term is extended for a further Three (3) years from August 1, 2007 to      July 31, 2010; |
|--------|-----|-------------------------------------------------------------------------------------------------------------|

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|   | (b) | Section      1(d) Expiry Date is extended to July 31,2010; |
|--------|-----|------------------------------------------------------------|

|   | (c) | Section      1(e) Basic Rent shall be amended by adding the  following: |
|--------|-----|-------------------------------------------------------------------------|

| Rental      Period                   | Annual      Basic Rent | Monthly      Basic Rent | Annual      Rate per square foot of Rentable Area |
|--------------------------------------|------------------------|-------------------------|---------------------------------------------------|
| August      1, 2007 to July 31, 2010 | $79,200.00             | $6,600.00               | $12.00                                            |

|   | (e) | The      Landlord’s address for service in Section 1(i) shall be deleted and      replaced with the following: |
|--------|-----|----------------------------------------------------------------------------------------------------------------------|

|   | (d) | The      Tenant shall have no right or option to extend or renew the Lease or the      term of the Lease. |
|--------|-----|-----------------------------------------------------------------------------------------------------------|

|   | (e) | The      Tenant accepts the Premises in their current “as is” condition and the      Landlord shall not provide any Landlord’s Work.  There shall be      no rental credit, rent free period, tenant allowance, Landlord’s Work,      Fixturing Period, leasehold improvements or other tenant inducement      whatsoever provided by theLandlord. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (f) | The      Tenant’s right of first offer to lease the ROFO Space is hereby terminated      and Sections 4 and 5 of Schedule D to the Lease are hereby deleted from      the Lease. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (g) | Section      5.5 of the Lease is hereby amended by deleting the word “audited” from the      ninth line thereof, so that the statement of Operating Costs and Realty      Taxes for the Project to be provided annually by the Landlord to the      Tenant shall not be required to be in audited  form. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3. | The      Landlord and the Tenant hereby acknowledge, confirm and agree that in all      other respects the terms of the Lease and the Rent Deposit Agreement are      to remain in full force and effect, unchanged and unmodified except in      accordance with this Agreement. |
|--------|----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 4. | Except      as specifically stated in this Agreement, any expression used in this      Agreement has the same meaning as the corresponding expression in the      Lease. |
|--------|----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 5. | This      Agreement shall enure to the benefit of and be binding upon the parties      hereto and their respective permitted successors and permitted      assigns. |
|--------|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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|   | 6. | This      Agreement may be executed by the parties hereto in separate counterparts,      each of which so executed shall be deemed to be an      original.  Such counterparts together shall constitute one and      the same instrument and, notwithstanding the date of execution, shall be      deemed to bear the effective date set forth  above. |
|--------|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Tenant:                                          |                               |
|--------|--------------------------------------------------|------------------------------------|
|   | OCCULOGIX,      INC.                             |                               |
|   |                                             |                               |   |   |
|   |                                             |                               |   |   |
|   | Per:                                             | “TomReeves”            |   |
|   |                                             | Name:                              | Tom      Reeves |   |
|   |                                             | Title:                             | President      & COO |   |
|   |                                             |                               |   |   |
|   |                                             |                               |   |   |
|   | Per:                                             | “William      Dumencu” |   |
|   |                                             | Name:                              | William      Dumencu |   |
|   |                                             | Title:                             | CFO      & Treasurer |   |
|   |                                             |                               |   |   |
|   |                                             |                               |   |   |
|   | I/We      have authority to bind the Corporation |                               |
|   |                                             |                               |   |   |
|   |                                             |                               |   |   |
|   | Landlord:                                        |                               |
|   | 2600      SKYMARK INVESTMENTS INC.               |                               |
|   |                                             |                               |   |   |
|   |                                             |                               |   |   |
|   | Per:                                             | “Michael Bunston”      |   |
|   |                                             | Name:                              | Michael      Bunston |   |
|   |                                             | Title:                             | President |   |
|   |                                             |                               |   |   |
|   | I      have authority to bind the Corporation    |                               |

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