3-decen-2-one DP Number: 373085

PC Code: 068403 EPA File Symbol No.: 5481-LAI

Type of Review: Human Health Toxicity

OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

MEMORANDUM

DATE: January 3, 2013

SUBJECT: Preliminary Product Chemistry Assessment for the Registration Review of 1-

Octen-3-ol (Octenol) and (R)-(-)-1-Octen-3-ol (R-Octenol).

Registration Review Case Number: 6033

Chemical Class: Biochemical

PC Codes: 069037 and 069038

CAS Number: 3391-86-4 and 3687-48-7

Type of Review: Product Chemistry Assessment

FROM: Colin G. Walsh, M.S., Biologist /s/ 01/03/2013

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P)

TO: Leonard Cole, Senior Regulatory Action Leader

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED

The following scoping document contains the preliminary product chemistry assessment for the 

biopesticides, 1-Octen-3-ol (Octenol) and (R)-(-)-1-Octen-3-ol (R-Octenol), in support of the 

development of the Registration Review Preliminary Work Plan. 
Octenol and R-Octenol PC Codes: 069037 and 069038

Type of Review: Product Chemistry Assessment (Registration Review)

2

Introduction

The Agency has determined that all necessary product chemistry information is available 

on the pesticide active ingredients, 1-Octen-3-ol (Octenol) and (R)-(-)-1-Octen-3-ol (ROctenol).

Octenol is a biochemical pesticide intended for use as an attractant for certain species of 

mosquitoes, biting flies, and other biting insects; however, the chemical itself does not kill 

insects. Octenol is typically used in conjunction with carbon dioxide and electronic devices that 

in turn kill the trapped insects. This form of Octenol, 1-Octen-3-ol, is the racemic mixture and 

includes all isomers of this chemical. The first product containing this active ingredient was 

registered with the Agency in 1996. Currently, there are seven active registrations containing 

Octenol; one manufacturing-use product (MP) and six end-use products (EPs).

R-Octenol is also a biochemical pesticide intended for use as an attractant for certain species of 

mosquitoes and other biting insects; however, the chemical itself does not kill insects. As with 

Octenol, R-Octenol is typically used in conjunction with carbon dioxide and electronic devices 

that in turn kill the trapped insects. This form of Octenol, (R)-(-)-1-Octen-3-ol, is a single isomer 

from the racemic mix. The first product containing this active ingredient was registered with the 

Agency in 2007. Currently, there are two active registrations containing R-Octenol; one MP and 

one EP.

Concerning the product chemistry of Octenol and R-Octenol, all biochemical pesticide data 

requirements for the technical grade active ingredients have been satisfied and are summarized in 

Table 3. UV/Visible light absorption data is the only product chemistry data outstanding for the 

products currently registered. Future registrations must adequately address all of the biochemical 

pesticides product chemistry data requirements.

Table 1. Product Identity and Composition for 1-Octen-3-ol

Common Name 1-Octen-3-ol (Octenol)

Chemical Name, IUPAC oct-1-en-3-ol
Octenol and R-Octenol PC Codes: 069037 and 069038

Type of Review: Product Chemistry Assessment (Registration Review)

3

Molecular Weight 128.21

PC Code 069037

CAS Registry Number 3391-86-4

Empirical Formula C8H16O

Registration Review Case Number 6033

Chemical Structure

Table 2. Product Identity and Composition for (R)-(-)-1-Octen-3-ol

Common Name (R)-(-)-1-Octen-3-ol (R-Octenol)

Chemical Name, IUPAC oct-1-en-3-ol

Molecular Weight 128.22

PC Code 069038

CAS Registry Number 3687-48-7

Empirical Formula C8H16O

Registration Review Case Number 6033
Octenol and R-Octenol PC Codes: 069037 and 069038

Type of Review: Product Chemistry Assessment (Registration Review)

4

Chemical Structure

Product Chemistry Summary 

The Agency has conducted reviews of the available product chemistry data and information for 

Octenol and R-Octenol. During the registration of the active ingredient, R-Octenol, the registrant 

requested to bridge the physical and chemical characteristics from Octenol to R-Octenol. The 

bridging request was acceptable to the Agency (EPA, 2007a). These data are summarized in 

Table 3, below.

Table 3. Biochemical Pesticides Product Chemistry Data Requirements for Octenol and ROctenol

Guideline No. Physical and Chemical 

Properties

Status1 Value MRID

830.1100 Product Identity and 

Composition

A Refer to Tables 1

and 2.

-

830.1200 Description of starting 

materials, production and 

formulation process

A CBI -

830.1400 Discussion of formation of 

impurities

A CBI -

830.1700 Preliminary analysis A CBI -

830.6302 Color A Colorless to pale 

yellow

45415201

830.6303 Physical state A Liquid at room 

temperature

45415201

830.6304 Odor A Earthy 45415201

830.6313 Stability to normal and 

elevated temperatures, 

A Stable at 54°C 

for 14 days; 

45503901; 

45585601
Octenol and R-Octenol PC Codes: 069037 and 069038

Type of Review: Product Chemistry Assessment (Registration Review)

5

metals and metal ions chemical not 

expected to be in 

contact with 

metals. 

830.7000 pH N/A N/A; not soluble 

or dispersible in 

water

-

830.7050 UV/Visible light absorption N/D - -

830.7200 Melting point/melting range N/A N/A; not a solid -

830.7220 Boiling point/boiling range A 175oC at 760 mm 

Hg

45415201

830.7300 Density A 0.84 g/ml at 

25oC

45415201

830.7520 Particle size, fiber length, 

and diameter distribution

N/A N/A; not a solid -

830.7550

830.7560

830.7570

Partition coefficient (nOctanol/Water)A Kow = 105 

(estimated)

45415201

830.7840 Water solubility A 9.7 x 10-8 mol/L 

(estimated)

45415201

830.7950 Vapor pressure A 0.5 mm Hg at 

20°C (estimated)

45415201

1. A=Acceptable. N/A=Not Applicable. N/D=Not Determined.

References

EPA. 2002. Memorandum from Paul Zubkoff to Todd Peterson. Chemistry Reviews of 

Bedoukian (2E)-1-octen-3-ol Technical. U.S. Environmental Protection Agency Office of 

Pesticide Programs. January 17, 2002.

EPA. 2006. Memorandum from Russell S. Jones to Todd Peterson. Science Review in Support of 

the Registration of the Manufacturing Use Product, Roctenol, Containing 98% (R)-(-)-1-Octen3-ol, A New Active Ingredient. Review of Product Chemistry, Tier 1 Toxicity Studies and 

Waiver Requests, Tier 1 Non-Target Organism Waiver Requests, and Endangered Species Risk 

Assessment. U.S. Environmental Protection Agency Office of Pesticide Programs. November 7, 

2006.

EPA. 2007a. Memorandum from Nina Simeonova to Todd Peterson. Response to the deficiency

letter submitted in support of application for registration of Roctenol TGAI, containing 98% (R)-

(-)-1-octen-3-ol as its active ingredient. U.S. Environmental Protection Agency Office of 

Pesticide Programs. June 18, 2007.

EPA. 2007b. Biopesticides Fact Sheet for 1-Octen-3-ol (069037) & R-(-)-1-Octen-3-ol (069038). 

U.S. Environmental Protection Agency Office of Pesticide Programs. July 5, 2007.

http://www.epa.gov/opp00001/chem_search/reg_actions/registration/fs_G-126_05-Jul-07.pdf
Octenol and R-Octenol PC Codes: 069037 and 069038

Type of Review: Product Chemistry Assessment (Registration Review)

6

Maloney, R. 2001. Product Chemistry of Bedoukian Octenol Technical. Unpublished study

prepared by Bedoukian Research, Inc. 34 p. MRID 45415201.

Maloney, R. 2001. Supplemental Product Chemistry for Bedoukian Octenol Technical. 

Unpublished study prepared by Bedoukian Research, Inc. 6 p. MRID 45503901.

Maloney, R. 2002. Supplemental Product Chemistry for Bedoukian Octenol Technical. 

Unpublished study prepared by Bedoukian Research Inc. 10 p. MRID 45585601

Pesticide Chemical Search. http://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:1:.

01/03/2013.

PubChem. http://pubchem.ncbi.nlm.nih.gov/. 01/03/2013.

cc: Colin G. Walsh, Leonard Cole, BPPD Science Review File, IHAD/ARS, Colin G. Walsh, FT, 

PY-S, January 3, 2013