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| x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|---|--------------------------------------------------------------------------------------|

| o | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|---|------------------------------------------------------------------------------------------|

| Delaware                                                       |   | 59-3434771                              |
|----------------------------------------------------------------|--------|-----------------------------------------|
| (State or other jurisdiction of incorporation or organization) |   | (I.R.S. Employer Identification Number) |

| 7360 Carroll Road, Suite 200San Diego, California |   | 92121      |
|---------------------------------------------------|--------|------------|
| (Address of principal executive offices)          |   | (Zip Code) |

| Title of each class            |   | Name of each exchange on which registered |
|--------------------------------|--------|-------------------------------------------|
| COMMON STOCK, $0.001 PAR VALUE |   | The Nasdaq Stock Market LLC               |
|                           |   | (The Nasdaq Capital Market)               |

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| Large accelerated filer o | Accelerated filer o                           | Non-accelerated filer o | Smaller reporting company x |
|---------------------------|-----------------------------------------------|-------------------------|-----------------------------|
|                      | (Do not check if a smaller reporting company) |

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|     |   |                                                                                           |   | Page |
|----------|--------|------------------------------------------------------------------------------------------------|--------|------|
| PART III |
| Item 10. |   | Directors, Executive Officers and Corporate Governance                                         |   | 1    |
| Item 11. |   | Executive Compensation                                                                         |   | 9    |
| Item 12. |   | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters |   | 15   |
| Item 13. |   | Certain Relationships and Related Transactions, and Director Independence                      |   | 16   |
| Item 14. |   | Principal Accounting Fees and Services                                                         |   | 18   |
| PART IV  |
| Item 15. |   | Exhibits, Financial Statement Schedules                                                        |   | 19   |

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| ITEM 10. | Directors, Executive Officers and Corporate Governance. |
|----------|---------------------------------------------------------|

| Name                    |   | Age |   | Position                                          |
|-------------------------|--------|-----|--------|---------------------------------------------------|
| Elias Vamvakas          |   | 52  |   | Chairman of the Board and Chief Executive Officer |
| Anthony E. Altig        |   | 55  |   | Director                                          |
| Thomas N. Davidson, Jr. |   | 51  |   | Director                                          |
| Adrienne L. Graves      |   | 56  |   | Director                                          |
| Paul M. Karpecki        |   | 44  |   | Director                                          |
| Richard L. Lindstrom    |   | 63  |   | Director                                          |
| Donald Rindell          |   | 58  |   | Director                                          |
| Brock Wright            |   | 51  |   | Director                                          |

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| Director                |           | Compensation |           | Corporate Governance and Nominating |           | Audit  |
|-------------------------|----------------|--------------|----------------|-------------------------------------|----------------|--------|
| Anthony E. Altig (1)    |   ▪ |         |   ▪ |                                |   ▪ | ü |
| Thomas N. Davidson, Jr. |   ▪ |         |   ▪ |                                |   ▪ | ü |
| Adrienne L. Graves (2)  |   ▪ | ü       |   ▪ | ü                              |   ▪ |   |
| Paul M. Karpecki        |   ▪ |         |   ▪ | ü                              |   ▪ |   |
| Richard L. Lindstrom    |   ▪ | ü       |   ▪ |                                |   ▪ |   |
| Donald Rindell (3)      |   ▪ |         |   ▪ | ü                              |   ▪ | ü |
| Brock Wright            |   ▪ | ü       |   ▪ |                                |   ▪ |   |

| (1) | Audit Committee Chair. |
|-----|------------------------|

| (2) | Compensation Committee Chair. |
|-----|-------------------------------|

| (3) | Corporate Governance and Nominating Committee Chair. |
|-----|------------------------------------------------------|

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|   | · | to establish criteria for Board and committee membership and to recommend to the Board proposed nominees for election to the Board and for membership on committees of the Board; |
|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | to ensure that appropriate processes are established by the Board to fulfill its responsibility for (i) the oversight of strategic direction and development and the review of ongoing results of operations of the Company by the appropriate committee of the Board and (ii) the oversight of the Company’s investor relations and public relations activities and ensuring that procedures are in place for the effective monitoring of the stockholder base, receipt of stockholder feedback and responses to stockholder concerns; |
|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | to monitor the quality of the relationship between management and the Board and to recommend improvements for ensuring an effective and appropriate relationship; and |
|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | to make recommendations to the Board regarding corporate governance matters and practices. |
|--------|--------|--------------------------------------------------------------------------------------------|

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|   | · | experience, skills and other qualifications in view of the specific needs of the Board and the Company; |
|--------|--------|---------------------------------------------------------------------------------------------------------|

|   | · | diversity of background; and |
|--------|--------|------------------------------|

|   | · | demonstration of high ethical standards, integrity and sound business judgment. |
|--------|--------|---------------------------------------------------------------------------------|

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| April 28, 2011 | AUDIT COMMITTEE    |
|----------------|--------------------|
|           |               |
|           | Anthony Altig      |
|           | Thomas N. Davidson |
|           | Donald Rindell     |

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|   | · | On July 1, 2010, the compensation committee of the Board granted options to Tom Davidson, Sr., Donald Rindell, Anthony Altig, Paul Karpecki, Richard Lindstrom and Adrienne Graves.  The Forms 4 were filed late on July 30, 2010. |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | On March 19, 2010, Elias Vamvakas acquired beneficial ownership of 24,395 shares of the Company’s common stock through an issuance to Marchant Securities Inc., related to the Canadian Placement Agency Agreement, as defined below under the heading “Interests of Insiders in Prior and Proposed Transactions.”  The Form 4 was filed late on April 22, 2011. |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | On March 19, 2010, Elias Vamvakas acquired beneficial ownership of 474,820 shares of the Company’s common stock through the purchase of shares by Greybrook Capital, Inc. in the First Quarter Private Placement, as defined below under the heading “Interests of Insiders in Prior and Proposed Transactions.”  The Form 4 was filed late on April 22, 2011. |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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ITEM 

| Name               |   | Age |   | Position                                          |
|--------------------|--------|-----|--------|---------------------------------------------------|
| Elias Vamvakas     |   | 52  |   | Chairman of the Board and Chief Executive Officer |
| William G. Dumencu |   | 56  |   | Chief Financial Officer                           |
| Duane Morrison     |   | 50  |   | Vice President, Sales                             |

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| Name and Principal Position          |   | Year |   | Salary ($) |    |   | Bonus ($) |   |    | Option Awards ($) (1) |   |   | All Other Compensation($) |   |   | Total($) |    |
|--------------------------------------|--------|------|--------|------------|---------|--------|-----------|--------|---------|-----------------------|--------|--------|---------------------------|--------|--------|----------|---------|
| Elias Vamvakas                       |   | 2010 |   |       | — |   |      |   | — |                  |   |   | —                   |   |   |     | 28,584  |   |   |   | 28,584 |   |
| Chairman and Chief Executive Officer |   | 2009 |   |       | — |   |      |   | — |                  |   |   | 466,488                   |   |   |     | 23,262  |   |   |   | 489,750 |   |
| William G. Dumencu                   |   | 2010 |   |       | 184,289 |   |      |   | 30,703  |                  |   |   | —                   |   |   |     | — |   |   |   | 214,992 |   |
| Chief Financial Officer              |   | 2009 |   |       | 146,329 |   |      |   | — |                  |   |   | 62,626                    |   |   |     | — |   |   |   | 208,955 |   |
| Duane Morrison                       |   | 2010 |   |       | 105,000 |   |      |   | — |                  |   |   | 184,300                   |   |   |     | — |   |   |   | 289,300 |   |
| Vice President, Sales                |   | 2009 |   |       | — |   |      |   | — |                  |   |   | —                   |   |   |     | — |   |   |   | — |   |

| (1) | The values set forth in this column are based on the full grant date fair value of stock option awards, computed in accordance with the provisions of FASB ASC Topic 718, using the Black-Scholes pricing model, utilizing certain assumptions as outlined in the footnotes to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2010.  These stock options include time-based stock options granted during the years ended December 31, 2010 and December 31, 2009. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|                    |   | Option Awards                                       |
|-------------------------|--------|-----------------------------------------------------|
| Name                    |   | Number of Securities Underlying Unexercised Options |   |   | Number of Securities Underlying Unexercised Options |   |   | Option Exercise Price |   | Option Expiration Date |
|                    |   | (#)Exercisable                                      |   |   | (#)Unexercisable |   |   | ($) |   |   |
| Elias Vamvakas (1)      |   |                                                | 184 |   |   |   | — |   |   |   | 32.50 |   | 8/1/2012 |
| Elias Vamvakas (2)      |   |                                                | 20,000 |   |   |   | — |   |   |   | 24.75 |   | 7/1/2013 |
| Elias Vamvakas (3)      |   |                                                | — |   |   |   | 4,500 |   |   |   | 51.25 |   | 3/30/2015 |
| Elias Vamvakas (4)      |   |                                                | 12,000 |   |   |   | — |   |   |   | 47.50 |   | 8/3/2016 |
| Elias Vamvakas (5)      |   |                                                | 4,000 |   |   |   | — |   |   |   | 27.75 |   | 7/3/2017 |
| Elias Vamvakas (6)      |   |                                                | 626,164 |   |   |   | — |   |   |   | 2.63 |   | 10/6/2018 |
| Elias Vamvakas (7)      |   |                                                | 15,000 |   |   |   | — |   |   |   | 2.00 |   | 6/18/2019 |
| Elias Vamvakas (8)      |   |                                                | 14,899 |   |   |   |   |   |   |   | 1.22 |   | 9/30/2019 |
| Elias Vamvakas (9)      |   |                                                | 45,000 |   |   |   | 90,000 |   |   |   | 1.22 |   | 9/30/2019 |
| Elias Vamvakas (10)     |   |                                                | 100,000 |   |   |   | — |   |   |   | 1.22 |   | 9/30/2019 |
| Elias Vamvakas (11)     |   |                                                | 200,000 |   |   |   | — |   |   |   | 1.22 |   | 9/30/2019 |
| William G. Dumencu (12) |   |                                                | 4,000 |   |   |   | — |   |   |   | 24.75 |   | 8/1/2013 |
| William G. Dumencu (13) |   |                                                | — |   |   |   | 1,800 |   |   |   | 51.25 |   | 3/30/2015 |
| William G. Dumencu (14) |   |                                                | 1,200 |   |   |   | — |   |   |   | 27.75 |   | 7/3/2017 |
| William G. Dumencu (15) |   |                                                | 37,665 |   |   |   | — |   |   |   | 2.63 |   | 10/6/2018 |
| William G. Dumencu (16) |   |                                                | 3,334 |   |   |   | 6,666 |   |   |   | 1.99 |   | 3/3/2019 |
| William G. Dumencu (17) |   |                                                | 17,445 |   |   |   | 34,890 |   |   |   | 1.22 |   | 9/30/2019 |
| Duane Morrison (18)     |   |                                                | 0 |   |   |   | 100,000 |   |   |   | 2.20 |   | 6/1/2020 |

| (1) | 184 post-split options were granted on August 1, 2002, under the Plan.  These time-based options have fully vested. |
|-----|-------------------------------------------------------------------------------------------------------------------------------|

| (2) | 20,000 post-split options were granted on July 1, 2003, under the Plan.  These time-based options have fully vested. |
|-----|--------------------------------------------------------------------------------------------------------------------------------|

| (3) | 4,500 post-split options were granted on March 30, 2005, under the Plan.  These performance-based options were to vest as follows: (a) as to 100% when and if the Company receives the approval that it is seeking from the U.S. Food and Drug Administration for the RHEO System for use in the Rheopheresis treatment of non-exudative age-related macular degeneration (the “FDA Approval”), if the FDA Approval is received on or before November 30, 2006; (b) as to 80% when and if the Company receives the FDA Approval, if the FDA Approval is received after November 30, 2006 but on or before January 31, 2007;(c) as to 60% when and if the Company receives the FDA Approval, if the FDA Approval is received after January 31, 2007. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | 12,000 post-split options were granted on August 3, 2006, under the Plan.  These options vested fully upon the date of grant. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------|

| (5) | 4,000 post-split options were granted on July 3, 2007, under the Plan.  These time-based options vest annually in 1/3 installments, starting on the one year anniversary of the date of grant. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | 626,164 post-split options were granted on October 6, 2008, under the Plan.  These options vested fully upon the date of grant. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | 15,000 options were granted on June 18, 2009, under the Plan.  These time-based options have fully vested. |
|-----|----------------------------------------------------------------------------------------------------------------------|

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| (8) | 14,899 options were granted on September 30, 2009, under the Plan.  These options vested fully upon the date of grant. |
|-----|----------------------------------------------------------------------------------------------------------------------------------|

| (9) | 135,000 options were granted on September 30, 2009, under the Plan.  These time-based options vest annually in 1/3 installments, starting on the one year anniversary of the date of grant. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (10) | 100,000 options were granted on September 30, 2009, under the Plan.  These time-based options vest monthly in 1/6 installments, starting on June 30, 2009. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (11) | 200,000 options were granted on September 30, 2009, under the Plan.  These time-based options vest monthly in 1/12 installments, starting on January 1, 2010. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (12) | 4,000 options were granted on August 1, 2003, under the Plan.  These time-based options are fully vested. |
|------|---------------------------------------------------------------------------------------------------------------------|

| (13) | 1,400 post-split options were granted on March 30, 2005, under the Plan.  These performance-based options were to vest as follows: (a) as to 100% when and if the Company receives the approval that it is seeking from the U.S. Food and Drug Administration for the RHEO System for use in the Rheopheresis treatment of non-exudative age-related macular degeneration (the “FDA Approval”), if the FDA Approval is received on or before November 30, 2006; (b) as to 80% when and if the Company receives the FDA Approval, if the FDA Approval is received after November 30, 2006, but on or before January 31, 2007; (c) as to 60% when and if the Company receives the FDA Approval, if the FDA Approval is received after January 31, 2007. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (14) 1,200 post-split options were granted on July 3, 2007, under the Plan.  These time-based options are fully vested. |
|--------|-----------------------------------------------------------------------------------------------------------------------------------|

| (15) | 37,665 post-split options were granted on October 6, 2008, under the Plan.  These options vested fully upon the date of grant. |
|------|------------------------------------------------------------------------------------------------------------------------------------------|

| (16) | 10,000 options were granted on March 3, 2009, under the Plan.  These time-based options vest annually in 1/3 installments, starting on the one year anniversary of the date of grant. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (17) | 52,335 options were granted on September 30, 2009, under the Plan.  These time-based options vest annually in 1/3 installments, starting on the one year anniversary of the date of grant. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (18) | 100,000 options were granted on June 1, 2010, under the Plan.  These time-based options vest annually in 1/3 installments, starting on the one year anniversary of the date of grant. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Name                    |   | Fees Earned or Paidin Cash ($) |    |   | StockAwards ($) |   |    | Option Awards ($) (1) |   |   | Non-Equity Incentive Plan Compensation ($) |   |   | Change in Pension Value and Nonqualified Deferred Compensation Earnings ($) |    |   | All Other Compensation ($) |   |    | Total ($) |   |
|-------------------------|--------|--------------------------------|---------|--------|-----------------|--------|---------|-----------------------|--------|--------|--------------------------------------------|--------|--------|-----------------------------------------------------------------------------|---------|--------|----------------------------|--------|---------|-----------|--------|
| Anthony E. Altig        |   |                           | — |   |            |   | — |                  |   |   | 29,398                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 29,398 |   |
| Thomas N. Davidson, Sr. |   |                           | — |   |            |   | — |                  |   |   | 17,122                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 17,122 |   |
| Adrienne L. Graves      |   |                           | — |   |            |   | — |                  |   |   | 25,008                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 25,008 |   |
| Paul M. Karpecki        |   |                           | — |   |            |   | — |                  |   |   | 44,172                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 44,172 |   |
| Richard Lindstrom       |   |                           | — |   |            |   | — |                  |   |   | 22,655                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 22,655 |   |
| Donald Rindell          |   |                           | — |   |            |   | — |                  |   |   | 28,472                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 28,472 |   |
| Brock Wright            |   |                           | — |   |            |   | — |                  |   |   | 37,534                                     |   |   |                                                                        | — |   |                       |   | — |      |   |   | — |   |   |   | 37,534 |   |

| (1) | The values set forth in this column are based on the full grant date fair value of stock option awards, computed in accordance with the provisions of FASB ASC Topic 718, using the Black-Scholes pricing model, utilizing certain assumptions as outlined in the footnotes to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2010.  These stock options include time-based stock options granted during the years ended December 31, 2010 and December 31, 2009. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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EM 

| Name of Beneficial Owner                                         |   | Shares Beneficially Owned |      |   | Percentage of Shares Beneficially Owned |   |
|------------------------------------------------------------------|--------|---------------------------|-----------|--------|-----------------------------------------|--------|
| 5% Stockholder:                                                  |   |                      |      |   |                                    |   |
| Eric Donsky (1)                                                  |   |                      | 1,609,880 |   |                                    |   | 10.8 | % |
| Executive Officers and Directors:                                |   |                      |      |   |                                    |   |   |   |
| Elias Vamvakas (2)                                               |   |                      | 1,895,486 |   |                                    |   | 12.0 | % |
| Duane Morrison                                                   |   |                      | 0         |   |                                    |   | * |   |
| William G. Dumencu (3)                                           |   |                      | 66,976    |   |                                    |   | * |   |
| Paul Karpecki (4)                                                |   |                      | 46,712    |   |                                    |   | * |   |
| Richard Lindstrom (5)                                            |   |                      | 154,307   |   |                                    |   | 1.0 | % |
| Adrienne Graves (6)                                              |   |                      | 52,350    |   |                                    |   | * |   |
| Donald Rindell (7)                                               |   |                      | 89,981    |   |                                    |   | * |   |
| Anthony Altig (8)                                                |   |                      | 58,287    |   |                                    |   | * |   |
| Brock Wright (9)                                                 |   |                      | 538,518   |   |                                    |   | 3.6 | % |
| Thomas N. Davidson, Jr. (10)                                     |   |                      | 147,619   |   |                                    |   | 1.0 | % |
| All directors and executive officers as a group (15 people) (11) |   |                      | 3,691,574 |   |                                    |   | 22.0 | % |

| (*) | Represents beneficial ownership of less than 1%. |
|-----|--------------------------------------------------|

| (1) | Includes 107,500 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|------------------------------------------------------------------------------------------|

| (2) | Includes (a) 1,037,247 shares subject to options exercisable within 60 days of March 15, 2011; (b) 551,011 shares held beneficially by Mr. Vamvakas through his relationship with Greybrook Corporation; (c) 306,428 shares held beneficially by Mr. Vamvakas through his relationship with Marchant Securities, Inc.; and (d) 800 shares held by Mr. Vamvakas.  Greybrook Corporation’s address is 5090 Explorer Drive, Suite 203, Mississauga, Ontario L4W 4T9.  Marchant Securities, Inc.’s address is 10 Wanless Avenue, Toronto, Ontario M4N 3B7. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Includes 66,976 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (4) | Includes 46,712 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (5) | Includes 68,069 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (6) | Includes 52,221 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (7) | Includes 89,981 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (8) | Includes 58,287 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (9) | Includes 15,122 shares subject to options exercisable within 60 days of March 15, 2011. |
|-----|-----------------------------------------------------------------------------------------|

| (10) | Includes (a) 3,750 shares subject to options exercisable within 60 days of March 15, 2011; (b) 104,079 shares held beneficially by Mr. Davidson through his relationship with Cardinal Crest Partners, 7 Sunrise Cay, Key Largo, FL 33037. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (11) | See footnotes 2 through 10 inclusive. |
|------|---------------------------------------|

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| Equity Compensation Plan Category      |   | Number of securities to be issued upon exercise of outstanding options, warrants and rights(a) |      |   | Weighted average exercise price of outstanding options, warrants and rights(b) |   |   | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a))(c) |   |
|----------------------------------------|--------|------------------------------------------------------------------------------------------------|-----------|--------|--------------------------------------------------------------------------------|--------|--------|------------------------------------------------------------------------------------------------------------------------------------------------|--------|
| Plans approved by security holders (1) |   |                                                                                           | 3,576,543 |   |                                                                           |   | 3.46   |                                                                                                                                           |   |   | –– |   |
| Plans not approved by security holders |   |                                                                                           |      |   |                                                                           |   |   |                                                                                                                                           |   |   |   |   |
| The 2007 Warrants (2)                  |   |                                                                                           | 127,050   |   |                                                                           |   | 46.25  |                                                                                                                                           |   |   | –– |   |
| The Cowen Warrants (3)                 |   |                                                                                           | 4,447     |   |                                                                           |   | 46.25  |                                                                                                                                           |   |   | –– |   |
| The 2010 Warrants (4)                  |   |                                                                                           | 621,118   |   |                                                                           |   | 4.00   |                                                                                                                                           |   |   | –– |   |
| Total                                  |   |                                                                                           | 752,615   |   |                                                                           |   | 11.38  |                                                                                                                                           |   |   | –– |   |

| (1) | For discussion of the 2002 Stock Incentive Plan, which was approved by the security holders, please refer to footnote 12 to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2010. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | On February 6, 2007, pursuant to a securities purchase agreement (the “2007 Securities Purchase Agreement”), the Company issued warrants to certain investors (the “2007 Warrants”).  The Warrants are five-year warrants exercisable into an aggregate of 106,838 shares of the Company's common stock at $46.25 per common share. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | On February 6, 2007, the Company issued a warrant to Cowen and Company, LLC (the “Cowen Warrant”) in partial payment of the placement fee payable for the services it had rendered as the placement agent in connection with the 2007 Securities Purchase Agreement.  The Cowen Warrant is a five-year warrant exercisable into an aggregate of 3,740 shares of the Company's common stock.  The per share exercise price of the Cowen Warrants is $46.25, and the Cowen Warrants became exercisable on August 6, 2007. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | On March 18, 2010, pursuant to a registered direct financing, the Company issued warrants to certain investors (the “2010 Warrants”).  The Warrants are eighteen month warrants exercisable into an aggregate of 621,118 shares of the Company's common stock at $4.00 per common share. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

ITEM 13.  

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ITEM 14

|               |   | For the years ended December 31, |   |
|--------------------|--------|---------------------------------------|--------|
|               |   | 2010 ($)                              |   |   | 2009 ($) |   |
|               |   | (in thousands)                        |   |
| Audit Fees         |   | $                                     | 236.0  |   |   | $ | 209.4 |   |
| Audit-Related Fees |   |                                  | 0.0    |   |   |   | 30.2 |   |
| Tax Fees           |   |                                  | 0.0    |   |   |   | 0.0 |   |
| All Other Fees     |   |                                  | 0.0    |   |   |   | 0.0 |   |
| Totals             |   | $                                     | 236.0  |   |   | $ | 239.6 |   |

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ITEM

| Exhibit Number | — | Exhibit Description                                                                                                                                                           |   | Incorporated by Reference                                                                                                                                                                                                                                                 |
|----------------|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 2.1            |    | Form of Plan of Reorganization.                                                                                                                                               |   | Exhibit 2.1 to the Registrant’s Registration Statement on Form S-1/A No. 4, filed with the Commission on December 6, 2004 (file no. 333-118024)                                                                                                                     |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 3.1            |    | Restated Certificate of Incorporation of OccuLogix, Inc., filed with the Secretary of State of the State of Delaware on October 7, 2008.                                      |   | Exhibit 3.3 to the Registrant’s Current Report on Form 8-K filed with the Commission on October 9, 2008 (file no. 000-51030)                                                                                                                                        |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 3.2            |    | Amended and Restated By-Laws of the Registrant as currently in effect.                                                                                                        |   | Exhibit 10.4 to the Registrant’s Registration Statement on Form S-1/A No. 3, filed with the Commission on November 16, 2004 (file no. 333-118024)                                                                                                                   |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 3.3            |    | Certificate of Amendment of OccuLogix, Inc., filed with the Secretary of State of the State of Delaware on October 7, 2008.                                                   |   | Exhibit 3.2 to the Registrant’s Current Report on Form 8-K filed with the Commission on October 9, 2008 (file no. 000-51030)                                                                                                                                        |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 3.4            |    | Certificate of Amendment of OccuLogix, Inc., filed with the Secretary of State of the State of Delaware on May 18, 2010.                                                      |   | Exhibit 3.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on May 19, 2010 (file no. 000-51030)                                                                                                                                           |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 4.1            |    | Form of Common Stock Purchase Warrant Agreement                                                                                                                               |   | Exhibit A to the Registrant’s free writing prospectus filed with the Commission on March 17, 2010 (file no. 333-157269)                                                                                                                                             |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 4.2            |    | Form of Common Stock Purchase Warrant Agreement                                                                                                                               |   | Exhibit 10.3 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 16, 2009 (file no. 000-51030)                                                                                                                                         |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 10.1           |    | Series A Stock Purchase Agreement by and among TearLab, Inc. and the Registrant dated as of November 30, 2006.                                                                |   | Exhibit 10.45 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)  (Exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K and will be provided to the SEC upon request.) |
|           |    |                                                                                                                                                                          |   |                                                                                                                                                                                                                                                                      |
| 10.2           |    | Securities Purchase Agreement, dated as of February 1, 2007, by and among the Registrant and the investors listed on the Schedule of Investors attached thereto as Exhibit A. |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K, filed with the Commission on February 6, 2007 (file no. 000-51030)                                                                                                                                     |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                                                                                  |   | Incorporated by Reference                                                                                                                                                                                                                        |
|----------------|---------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.3           | #       | Employment Agreement between the Registrant and Suh Kim dated as of March 12, 2007.                                                                                                                                                                                  |   | Exhibit 10.47 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)                                                                                                           |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.4           |    | License Agreement between TearLab, Inc. and The Regents of the University of California dated March 12, 2003.                                                                                                                                                        |   | Exhibit 10.48 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)  (Portions of this exhibit have been omitted pursuant to a request for confidential treatment.) |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.5           |    | Amendment No. 1, dated June 9, 2003, to the License Agreement between TearLab, Inc. and The Regents of the University of California dated March 12, 2003.                                                                                                            |   | Exhibit 10.49 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)                                                                                                           |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.6           |    | Amendment No. 2, dated September 5, 2005, to the License Agreement between TearLab, Inc. and The Regents of the University of California dated March 12, 2003.                                                                                                       |   | Exhibit 10.50 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)  (Portions of this exhibit have been omitted pursuant to a request for confidential treatment.) |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.7           |    | Amendment No. 3, dated July 7, 2006, to the License Agreement between TearLab, Inc. and The Regents of the University of California dated March 12, 2003.                                                                                                            |   | Exhibit 10.51 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)                                                                                                           |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.8           |    | Amendment No. 4, dated October 9, 2006, to the License Agreement between TearLab, Inc. and The Regents of the University of California dated March 12, 2003.                                                                                                         |   | Exhibit 10.52 to the Registrant’s Annual Report on Form 10-K/A, filed with the Commission on March 29, 2007 (file no. 000-51030)                                                                                                           |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.9           |    | Terms of Business, dated February 5, 2007, between Invetech Pty Ltd. and TearLab, Inc.                                                                                                                                                                               |   | Exhibit 10.30 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)                                                                                                             |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.10          |    | Amendment No. 5, dated June 29, 2007, to the License Agreement between TearLab, Inc. and The Regents of the University of California dated March 12, 2003.  (Portions of this exhibit have been omitted pursuant to a request for confidential treatment.) |   | Exhibit 10.31 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)                                                                                                             |
|           |    |                                                                                                                                                                                                                                                                 |   |                                                                                                                                                                                                                                             |
| 10.11          |    | Lease, dated October 17, 2005, between Penyork Properties III Inc. and the Registrant.                                                                                                                                                                               |   | Exhibit 10.32 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)                                                                                                             |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |   | Incorporated by Reference                                                                                                                |
|----------------|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.12          |    | Lease Amending Agreement, dated as of March 9, 2007, between the Registrant and 2600 Skymark Investments Inc., amending the Lease between Penyork Properties III Inc. and the Registrant dated October 17, 2005.                                                                                                                                                                                                                                                                                    |   | Exhibit 10.33 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.13          |    | 2002 Stock Option Plan, as amended and restated on June 24, 2010.                                                                                                                                                                                                                                                                                                                                                                                                                                   |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K, filed with the Commission on July 23, 2010 (file no. 000-51030)       |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.14          |    | Manufacturing and Development Agreement, dated October 25, 2007, between MiniFAB (Aust) Pty Ltd and TearLab, Inc.  (Portions of this exhibit have been omitted pursuant to a request for confidential treatment.)                                                                                                                                                                                                                                                                         |   | Exhibit 10.35 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.15          |    | First Amendment to Series A Preferred Stock Purchase Agreement, dated October 29, 2007, between TearLab, Inc. and the Registrant                                                                                                                                                                                                                                                                                                                                                                    |   | Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on November 9, 2007 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.16          |    | Research Agreement, dated as of December 13, 2007, between * and TearLab, Inc. (Portions of this exhibit have been omitted pursuant to a request for confidential treatment.)                                                                                                                                                                                                                                                                                                                       |   | Exhibit 10.37 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.17          |    | Stock Purchase Agreement, dated as of December 19, 2007, between the Registrant and Solx Acquisition, Inc.  (Exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K and will be provided to the Commission upon request.)                                                                                                                                                                                                                                                |   | Exhibit 10.38 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.18          |    | Amending Agreement, dated as of December 19, 2007, by and among the Registrant, Solx, Inc. and Peter M. Adams, acting for and on behalf of the Stockholder Representative Committee, amending the Agreement and Plan of Merger, dated as of August 1, 2006, by and among the Registrant, OccuLogix Mergeco, Inc., Solx, Inc. and Doug P. Adams, John Sullivan and Peter M. Adams, acting in each case, in his capacity as a member of the Stockholder Representative Committee referred to therein. |   | Exhibit 10.39 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                     |
| 10.19          | #       | Termination Agreement, dated as of December 19, 2007, between Doug P. Adams and the Registrant, terminating the Employment Agreement between the Registrant and Doug P. Adams dated as of September 1, 2006.                                                                                                                                                                                                                                                                                        |   | Exhibit 10.40 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030)     |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                              |   | Incorporated by Reference                                                                                                            |
|----------------|---------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.20          |    | Limited Guaranty, dated as of December 19, 2007, by Doug P. Adams for the benefit of the Registrant.                                                                                                             |   | Exhibit 10.41 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.21          |    | Security Agreement, dated as of December 19, 2007, by Solx, Inc. in favor of the Registrant.                                                                                                                     |   | Exhibit 10.42 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.22          |    | Letter Agreement, dated December 20, 2007, between the Registrant and Solx Acquisition, Inc.                                                                                                                     |   | Exhibit 10.43 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.23          | #       | Termination Agreement, dated as of January 4, 2008, between John Cornish and the Registrant, terminating the Employment Agreement between the Registrant and John Cornish dated as of April 1, 2005, as amended. |   | Exhibit 10.44 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.24          | #       | Termination Agreement, dated as of January 4, 2008, between Julie Fotheringham and the Registrant, terminating the Employment Agreement between the Registrant and Julie Fotheringham dated September 1, 2004.   |   | Exhibit 10.45 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.25          | #       | Termination Agreement, dated as of January 4, 2008, between Stephen Parks and the Registrant, terminating the Employment Agreement between Stephen Parks and the Registrant dated as of October 4, 2005.         |   | Exhibit 10.46 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.26          | #       | Termination Agreement, dated as of January 8, 2008, between David C. Eldridge and the Registrant, terminating the Employment Agreement between the Registrant and Dr. David Eldridge dated November 9, 2004.     |   | Exhibit 10.47 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.27          | #       | Termination Agreement, dated as of January 31, 2008, between Nozhat Choudry and the Registrant, terminating the Employment Agreement between Nozhat Choudry and the Registrant, as amended.                      |   | Exhibit 10.48 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                             |   |                                                                                                                                 |
| 10.28          | #       | Termination Agreement, dated as of January 31, 2008, between Stephen Kilmer and the Registrant, terminating the Employment Agreement between the Registrant and Stephen Kilmer dated July 30, 2004.              |   | Exhibit 10.49 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                         |   | Incorporated by Reference                                                                                                            |
|----------------|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.29          |    | Loan Agreement, dated as of February 19, 2008, by and among the Registrant, the Lenders named therein and Marchant Securities Inc.                                                                          |   | Exhibit 10.50 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.30          |    | Share Pledge Agreement, dated as of February 19, 2008, by the Registrant in favor of Marchant Securities Inc., as collateral agent.                                                                         |   | Exhibit 10.51 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.31          | #       | Employment Agreement, dated as of February 25, 2008, between the Registrant and William G. Dumencu.                                                                                                         |   | Exhibit 10.52 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.32          | #       | Termination Agreement, dated as of February 25, 2008, between Asahi Kasei Kuraray Medical Co., Ltd. and the registrant.                                                                                     |   | Exhibit 10.53 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.33          | #       | Amending Agreement, dated as of March 3, 2008, between Nozhat Choudry and the Registrant, amending the Termination Agreement between Nozhat Choudry and the Registrant dated as of January 31, 2008.        |   | Exhibit 10.54 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.34          | #       | Amending Agreement, dated as of March 3, 2008, between John Cornish and the Registrant, amending the Termination Agreement between John Cornish and the Registrant dated as of January 4, 2008.             |   | Exhibit 10.55 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.35          | #       | Amending Agreement, dated as of March 3, 2008, between David C. Eldridge and the Registrant, amending the Termination Agreement between David C. Eldridge and the Registrant dated as of January 8, 2008.   |   | Exhibit 10.56 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.36          | #       | Amending Agreement, dated as of March 3, 2008, between Julie Fotheringham and the Registrant, amending the Termination Agreement between Julie Fotheringham and the Registrant dated as of January 4, 2008. |   | Exhibit 10.57 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                        |   |                                                                                                                                 |
| 10.37          | #       | Amending Agreement, dated as of March 3, 2008, between Stephen Parks and the Registrant, amending the Termination Agreement between Stephen Parks and the Registrant dated as of January 4, 2008.           |   | Exhibit 10.58 to the Registrant’s Annual Report on Form 10-K, filed with the Commission on March 17, 2008 (file no. 000-51030) |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   | Incorporated by Reference                                                                                                               |
|----------------|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.38          |    | Agreement and Plan of Merger and Reorganization, dated April 22, 2008, by and among the Registrant, OcuSense Acquireco, Inc. and TearLab, Inc. (formerly known as OcuSense, Inc.) (Exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K and will be provided to the SEC upon request.)                                                                                                                                                                                                                                                               |   | Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on May 12, 2008 (file no. 000-51030)    |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.39          |    | Amending Agreement, dated as of May 5, 2008, by and among the Registrant, the lenders listed on the Schedule of New Lenders attached there to as Exhibit A, the lenders listed the Schedule of Required Lenders attached thereto as Exhibit B and Marchant Securities Inc., amending the Loan Agreement, dated as of February 19, 2008, by and among the Registrant, the Lenders named therein and Marchant Securities Inc. and the Share Pledge Agreement, dated as of February 19, 2008, by the Registrant in favor of Marchant Securities Inc., as collateral agent. |   | Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on May 12, 2008 (file no. 000-51030)    |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.40          |    | Securities Purchase Agreement, dated as of May 19, 2008, by and among OccuLogix, Inc., Marchant Securities Inc. and the investors listed on the Schedule of Investors attached thereto as Exhibit A.                                                                                                                                                                                                                                                                                                                                                                    |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K, filed with the Commission on May 21, 2008 (file no. 000-51030)       |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.41          |    | Amending Agreement by and among OccuLogix, Inc., Marchant Securities Inc. and the investor party thereto.                                                                                                                                                                                                                                                                                                                                                                                                                                                               |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 28, 2008 (file no. 000-51030)       |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.42          |    | Amending Agreement, dated as of July 28, 2008, by and among OccuLogix, Inc., OcuSense Acquireco, Inc. and TearLab, Inc. (formerly known as OcuSense, Inc.)                                                                                                                                                                                                                                                                                                                                                                                                              |   | Exhibit 10.2 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 28, 2008 (file no. 000-51030)       |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.43          | #       | Second Amending Agreement, dated as of June 16, 2008, between John Cornish and the Registrant, amending the Termination Agreement between the Registrant and John Cornish dated as of January 4, 2008, as amended.                                                                                                                                                                                                                                                                                                                                                      |   | Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   |                                                                                                                                    |
| 10.44          | #       | Second Amending Agreement, dated as of June 16, 2008, between Julie Fotheringham and the Registrant, amending the Termination Agreement between the Registrant and Julie Fotheringham dated as of January 4, 2008, as amended.                                                                                                                                                                                                                                                                                                                                          |   | Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                                           |   | Incorporated by Reference                                                                                                                |
|----------------|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.45          | #       | Amending Agreement, dated as of June 16, 2008, between Stephen Kilmer and the Registrant, amending the Termination Agreement between the Registrant and Stephen Kilmer dated as of January 31, 2008.                          |   | Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.46          | #       | Second Amending Agreement, dated as of June 16, 2008, between David C. Eldridge and the Registrant, amending the Termination Agreement between the Registrant and David C. Eldridge dated as of January 8, 2008, as amended.  |   | Exhibit 10.4 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.47          | #       | Second Amending Agreement, dated as of June 16, 2008, between Stephen Parks and the Registrant, amending the Termination Agreement between the Registrant and Stephen Parks dated as of January 4, 2008, as amended.          |   | Exhibit 10.5 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.48          | #       | Second Amending Agreement, dated as of June 19, 2008, between Nozhat Choudry and the Registrant, amending the Termination Agreement between the Registrant and Nozhat Choudry dated as of January 31, 2008, as amended.       |   | Exhibit 10.6 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.49          | #       | Termination Agreement, dated as of June 30, 2008, between Thomas P. Reeves and the Registrant, terminating the Employment Agreement between the Registrant and Thomas P. Reeves dated as of August 1, 2004, as amended.       |   | Exhibit 10.7 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.50          | #       | Third Amending Agreement, dated as of July 25, 2008, between John Cornish and the Registrant, amending the Termination Agreement between the Registrant and John Cornish dated as of January 4, 2008, as amended.             |   | Exhibit 10.8 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.51          | #       | Third Amending Agreement, dated as of July 25, 2008, between Julie Fotheringham and the Registrant, amending the Termination Agreement between the Registrant and Julie Fotheringham dated as of January 4, 2008, as amended. |   | Exhibit 10.9 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030)  |
|           |    |                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.52          | #       | Second Amending Agreement, dated as of July 25, 2008, between Stephen Kilmer and the Registrant, amending the Termination Agreement between the Registrant and Stephen Kilmer dated as of January 31, 2008, as amended.       |   | Exhibit 10.10 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |   | Incorporated by Reference                                                                                                                |
|----------------|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.53          | #       | Third Amending Agreement, dated as of July 25, 2008, between David C. Eldridge and the Registrant, amending the Termination Agreement between the Registrant and David C. Eldridge dated as of January 8, 2008, as amended.                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   | Exhibit 10.11 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.54          | #       | Third Amending Agreement, dated as of July 25, 2008, between Stephen Parks and the Registrant, amending the Termination Agreement between the Registrant and Stephen Parks dated as of January 4, 2008, as amended.                                                                                                                                                                                                                                                                                                                                                                                                                                                           |   | Exhibit 10.12 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.55          | #       | Third Amending Agreement, dated as of July 25, 2008, between Nozhat Choudry and the Registrant, amending the Termination Agreement between the Registrant and Nozhat Choudry dated as of January 31, 2008, as amended.                                                                                                                                                                                                                                                                                                                                                                                                                                                        |   | Exhibit 10.13 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.56          | #       | Amending Agreement, dated as of July 25, 2008, between Thomas P. Reeves and the Registrant, amending the Termination Agreement between the Registrant and Thomas P. Reeves dated as of June 30, 2008.                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |   | Exhibit 10.14 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.57          |    | Second Amending Agreement, dated as of July 28, 2008, by and among the Registrant, the lenders listed on the Schedule of Second New Lenders attached thereto as Exhibit A, the lenders listed on the Schedule of Required Lenders attached thereto as Exhibit B and Marchant Securities Inc., amending the Loan Agreement, dated as of February 19, 2008, by and among the Registrant, the lenders listed on the Schedule of Lenders attached thereto as Exhibit A and Marchant Securities Inc., as amended, and amending the Share Pledge Agreement, dated as of February 19, 2008, by the Registrant in favor of Marchant Securities Inc., as collateral agent, as amended. |   | Exhibit 10.15 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 11, 2008 (file no. 000-51030) |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.58          |    | Loan Agreement, dated as of August 13, 2008, by and among OccuLogix, Inc. and TearLab, Inc. (formerly known as OcuSense, Inc.)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on August 15, 2008 (file no. 000-51030)      |
|           |    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                                     |
| 10.59          |    | Second Amending Agreement, dated as of October 6, 2008, by and among OccuLogix, Inc., OcuSense Acquireco, Inc. and TearLab, Inc. (formerly known as OcuSense, Inc.)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on October 9, 2008 (file no. 000-51030)      |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                                                                                 |   | Incorporated by Reference                                                                                                              |
|----------------|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.60          |    | Second Amending Agreement, dated as of October 1, 2008, by and among OccuLogix, Inc., Marchant Securities Inc. and the investors listed on the Schedule of Investors attached thereto as Exhibit A. |   | Exhibit 10.2 to the Registrant’s Current Report on Form 8-K filed with the Commission on October 9, 2008 (file no. 000-51030)    |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.61          |    | Letter Agreement, dated January 8, 2010, amending the Capital Advisory Agreement with Greybrook Capital Inc.                                                                                        |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on January 11, 2010 (file no. 000-51030)   |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.62          |    | Placement Agency Agreement, dated as of March 14, 2010, by and between the Company and Rodman & Renshaw, LLC.                                                                                   |   | Exhibit 99.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on March 15, 2010 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.63          |    | Securities Purchase Agreement, dated as of March 14, 2010, by and between the Company and certain investors.                                                                                        |   | Exhibit A to the Registrant’s free writing prospectus filed with the Commission on March 17, 2010 (file no. 333-157269)          |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.64          |    | Distribution Agreement, dated as of August 20, 2009, by and between the Company and Science with Vision, a Canadian corporation.                                                                    |   | Exhibit 99.5 to the Registrant’s Current Report on Form 8-K filed with the Commission on March 15, 2010 (file no. 000-51030)     |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.65          |    | Capital Advisory Agreement with Greybrook Capital Inc., dated November 3, 2009                                                                                                                      |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on November 3, 2009 (file no. 000-51030)   |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.66          |    | Securities Purchase Agreement, dated as of July 15, 2009, by and between the Company and certain investors.                                                                                         |   | Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 16, 2009 (file no. 000-51030)      |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.67          |    | Form of 12% Convertible Secured Note.                                                                                                                                                               |   | Exhibit 10.2 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 16, 2009 (file no. 000-51030)      |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.68          |    | Security Agreement, dated July 15, 2009, by and between the Company and certain investors.                                                                                                          |   | Exhibit 10.4 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 16, 2009 (file no. 000-51030)      |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 10.69          |    | Form of Director and Affiliate Letter Agreement.                                                                                                                                                    |   | Exhibit 10.5 to the Registrant’s Current Report on Form 8-K filed with the Commission on July 16, 2009 (file no. 000-51030)      |
|           |    |                                                                                                                                                                                                |   |                                                                                                                                   |
| 14.1           |    | Code of Business Conduct and Ethics of the Registrant                                                                                                                                               |   | Exhibit 14.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 9, 2005 (file no. 000-51030) |

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Table of Contents

| Exhibit Number | — | Exhibit Description                                                                                                                     |   | Incorporated by Reference                                                                                                              |
|----------------|---------|-----------------------------------------------------------------------------------------------------------------------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------|
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 14.2           |    | Complaint and Reporting Procedures of the Registrant.                                                                                   |   | Exhibit 14.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the Commission on August 9, 2005 (file no. 000-51030) |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 21.1           |    | Subsidiaries of Registrant.                                                                                                             |   | Exhibit 21.1 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 (filed on March 29, 2011)       |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 23.1           |    | Consent of Independent Registered Public Accounting Firm.                                                                               |   | Exhibit 23.1 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 (filed on March 29, 2011)       |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 24.1           |    | Power of Attorney (included on signature page).                                                                                         |   | Included on signature page to original filing on March 26, 2010                                                                        |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 31.1           |    | CEO’s Certification required by Rule 13A-14(a) of the Securities Exchange Act of 1934.                                            |   | Filed herewith.                                                                                                                        |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 31.2           |    | CFO’s Certification required by Rule 13A-14(a) of the Securities Exchange Act of 1934.                                            |   | Filed herewith.                                                                                                                        |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 32.1           |    | CEO’s Certification of periodic financial reports pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, U.S.C. Section 1350. |   | Exhibit 32.1 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 (filed on March 29, 2011)       |
|           |    |                                                                                                                                    |   |                                                                                                                                   |
| 32.2           |    | CFO’s Certification of periodic financial reports pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, U.S.C. Section 1350. |   | Exhibit 32.2 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 (filed on March 29, 2011)       |

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Table of Contents

| Dated: April 28, 2011 |   | TEARLAB CORPORATION |                    |
|-----------------------|--------|---------------------|-------------------------|
|                  |   | By:                 | /s/ Elias Vamvakas      |   |
|                  |   |                | Elias Vamvakas          |   |
|                  |   |                | Chief Executive Officer |   |

| Dated: April 28, 2011 |               | By:    | /s/ Elias Vamvakas     |
|-----------------------|--------------------|--------|------------------------|
|                  |               |   |                   | Elias Vamvakas |
|                  |               |   |                   | Chief Executive Officer and |
|                  |               |   |                   | Chairman of Board of Directors |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ William G. Dumencu |
|                  |               |   |                   | William G. Dumencu |
|                  |               |   |                   | Chief Financial Officer and Treasurer |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Anthony Altig |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Thomas N. Davidson, Jr. |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Adrienne L. Graves |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Richard L. Lindstrom, M.D. |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Donald Rindell |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Paul Karpecki |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| Dated: April 28, 2011 |               | By:    | /s/ *                  |
|                  |               |   |                   | Brock Wright |
|                  |               |   |                   | Director |
|                  |               |   |                   |   |
| *By:                  | /s/ Elias Vamvakas |   |                   |   |
|                  | Elias Vamvakas     |   |                   |   |
|                  | Attorney-in-Fact   |   |                   |   |

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