Saflufenacil Dietary Exposure and Risk Assessment

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

MEMORANDUM

DATE: 04-AUG-2011

SUBJECT: Saflufenacil. Acute and 

Exposure and Risk Assessment for 

Coffee, Banana, and Mango

PC Code: 118203

Decision No.: 442242 

Petition No.: 0E7806

Risk Assessment Type: Dietary

TXR No.: NA

MRID No.: NA

FROM: George F. Kramer, Ph.D., 

Risk Assessment Branch 

THROUGH: David E. Hrdy, Senior Biologist

Dennis McNeilly, Chemist

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

Dana M. Vogel, Branch Chief

RAB1/HED (7509P)

TO: George F. Kramer, Ph.D., 

RAB1/HED (7509P)

and

Kathryn Montague/

Registration Division (RD) (7505P)

Executive Summary

Acute and chronic dietary-exposure and risk assessments were conducted 

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM

FCIDTM, Version 2.03) which use food consumption data from the U.S. Department of 

Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994

Dietary Exposure and Risk Assessment DP Number: 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

CHEMICAL SAFETY AND

POLLUTION PREVENTION

Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for Tolerances for Residues in/on

Coffee, Banana, and Mango.

DP Barcode: D390923

Registration No.: 7969-278

Regulatory Action: Tolerances With No U.S. 

Registration

Dietary Case No.: NA

CAS No.: 372137-35-4

40 CFR: §180.649

George F. Kramer, Ph.D., Senior Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

Hrdy, Senior Biologist

Dennis McNeilly, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Dana M. Vogel, Branch Chief

RAB1/HED (7509P)

George F. Kramer, Ph.D., Risk Assessor

RAB1/HED (7509P)

Kathryn Montague/Susan Stanton, PM Team 23

Registration Division (RD) (7505P)

exposure and risk assessments were conducted using the 

ware with the Food Commodity Intake Database (DEEM

which use food consumption data from the U.S. Department of 

Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994

DP Number: 390923

______________________________________________________________________________________

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF

CHEMICAL SAFETY AND

POLLUTION PREVENTION

Chronic Aggregate Dietary (Food and Drinking Water) 

Tolerances for Residues in/on Imported 

Tolerances With No U.S. 

/Health Effects Division (HED; 7509P)

using the Dietary

ware with the Food Commodity Intake Database (DEEMwhich use food consumption data from the U.S. Department of 

Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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1998. These analyses were performed to support a tolerance petition for residues in/on imported 

coffee, banana, and mango. 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

The unrefined acute analysis assumed 100% crop treated (CT), DEEMTM 7.81 default 

concentration factors, and tolerance-level residues for all commodities [except for cottonseed; 

sunflower subgroup 20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except 

soybean); and rapeseed subgroup 20A – see Section II for more details]. The drinking water 

estimate from the existing U.S. uses was incorporated directly into the dietary assessment using 

the concentration for ground water generated by the Tier II Pesticide Root Zone Model Ground 

Water (PRZM GW). The acute dietary risk estimates (food + water) at the 95th percentile are 

<1% of the acute population-adjusted dose (aPAD) for the general U.S. population and <1% of 

the aPAD for the most highly exposed population subgroup (all infants (<1 year old)) and are 

thus below HED’s level of concern (<100% aPAD).

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The unrefined chronic analysis assumed 100% CT, DEEMTM 7.81 default concentration factors,

and tolerance-level residues for all commodities [except for cottonseed; sunflower subgroup 

20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); and 

rapeseed subgroup 20A – see Section II for more details]. The drinking water estimate from the 

existing U.S. uses was incorporated directly into the dietary assessment using the concentration 

for ground water generated by PRZM GW. The chronic dietary risk estimates (food + water) 

9.2% of the chronic population-adjusted dose (cPAD) for the general U.S. population and 31% 

of the cPAD for the most highly exposed population subgroup (all infants (<1 year old)) and are 

thus below HED’s level of concern (<100% cPAD).

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Saflufenacil is classified as “not likely carcinogenic to humans.” Therefore, cancer risk is not a 

concern for this chemical.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to point of departure (POD, 

NOAEL, LOAEL, i.e.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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The most recent dietary exposure risk assessment for saflufenacil was conducted by G. Kramer 

(Memo, 24-MAR-2011, D381976).

II. Residue Information

Saflufenacil Proposed and Registered Uses:

Saflufenacil is currently registered for use on legume vegetables (crop group 06), the foliage of 

legume vegetables (crop group 07), cereal grains (crop group 15), forage, fodder, and straw of 

cereal grains (crop group 16), cottonseed (subgroup 20C), rapeseed (subgroup 20A), and 

sunflower (subgroup 20B). BASF has submitted a tolerance petition for residues in/on imported 

coffee, banana, and mango. 

Residues of Concern: The nature of the residue in plants, rotational crops, and livestock is 

adequately understood based on acceptable metabolism studies conducted on corn (preplant

application), soybean (preplant and preharvest application), tomato (preplant application), 

rotational crops, lactating goats, and laying hens. The HED Residues of Concern 

Knowledgebase Subcommittee (ROCKS) determined that residues of concern for the tolerance 

expression and risk assessment in plants consist of saflufenacil, M800H11, and M800H35; and

that saflufenacil is the only residue of concern in livestock (Memo, B. Daiss, 1/6/09; D359645). 

An additional major metabolite (M800H02) that is not included in the tolerance expression was 

observed in soybean seed following preharvest (harvest aid) application. As the structure of 

M800H02 is closely related to the parent compound and it is the precursor of the regulated 

metabolite M800H11, RAB1 concludes that M800H02 is a residue of concern for riskassessment purposes in crops following post-emergence treatment. 

Table 1. Summary of Metabolites and Degradates to be Included in the Risk Assessment.

Matrix Residues included in Risk 

Assessment

Residues included in 

Tolerance Expression

Plants

Primary Crops (preplant 

application)

Saflufenacil + M800H11, 

M800H35

Saflufenacil + M800H11, 

M800H35

Primary Crops 

(preharvest application)

Saflufenacil + M800H11, 

M800H02, M800H35

Rotational Crops Saflufenacil + M800H11, 

M800H35

Livestock

Ruminants

Saflufenacil Saflufenacil

Poultry

Drinking Water

Saflufenacil + M800H01, 

M800H02, M800H07, M800H08, 

M800H15, M800H22, Product 8

Not Applicable

Established Tolerances: Permanent tolerances for “saflufenacil, including its metabolites and 

degradates, in or on the commodities in the table below. Compliance with the tolerance levels 

specified below is to be determined by measuring only the sum of saflufenacil, 2-chloro-5-[3,6-

dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-

methylethyl)amino]sulfonyl]benzamide, and its metabolites N-[2-chloro-5-(2,6-dioxo-4-

(trifluoromethyl)-3,6-dihydro-1(2H)-pyrimidinyl)-4-fluorobenzoyl]-N'-isopropylsulfamide and 

N-[4-chloro-2-fluoro-5-({[(isopropylamino)sulfonyl]amino}carbonyl)phenyl]urea, calculated as 

the stoichiometric equivalent of saflufenacil” are currently established under 40 CFR 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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§180.649(a)(1) for residues on citrus fruit (Crop Group 10), pome fruit (Crop Group 11), stone

fruit (Crop Group 12), grape, tree nuts (Crop Group 14), legume vegetables (crop group 06), the 

foliage of legume vegetables (crop group 07), cereal grains (crop group 15), forage, fodder, and 

straw of cereal grains (crop group 16), cottonseed (subgroup 20C), rapeseed (subgroup 20A), and 

sunflower (subgroup 20B). Additionally, permanent tolerances for “saflufenacil, including its 

metabolites and degradates, in or on the commodities in the table below. Compliance with the 

tolerance levels specified below is to be determined by measuring only saflufenacil, 2-chloro-5-

[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-

methylethyl)amino]sulfonyl]benzamide” are currently established under 40 CFR §180.649(a)(2) 

for residues on livestock commodities.

Recommended Tolerances: Based on the residue chemistry data submitted with the current 

petition, HED recommended for establishment of the following tolerances (G. Kramer, 04-AUG2011; D390922):

Table 2. Tolerance Summary for Saflufenacil.

Commodity Recommended Tolerance (ppm)

Coffee, green bean 0.03 

Banana 0.03

Mango 0.03

Residue Data used for Acute and Chronic Assessments:

The acute and chronic assessments were based on the assumption of tolerance-level residues for 

all commodities, except for cottonseed; sunflower subgroup 20B; soybean, seed; vegetable, 

legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A. For these 

crops, residues were also based on the recommended tolerances; however, a correction factor 

was applied to the tolerance level to account for the M800H02 metabolite included in the risk 

assessment as a result of preharvest uses. The additional metabolite, M800H02, was observed in 

the metabolism studies of preharvest-treated soybean seed, comprising 26.3% of the total 

radioactive residues (G. Kramer, 3/24/11; DP# 381129). Since the toxicity of the M800H02 is 

expected to be comparable to the parent compound, it was included in the risk assessment for 

preharvest uses, but not in the tolerance expression. To account for this additional toxicity

exposure, the recommended tolerance level was multiplied by a correction factor of 1.7x, where 

1.7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression). 

1.7 = (Saflufenacil + M800H11 + M800H02 + M800H35)/(Saflufenacil + M800H11 + M800H35) = 

(26.1% + 10.9% + 26.3% + 0%)/(26.1% + 10.9% + 0%)

Therefore, in the acute and chronic assessments, a residue of 0.34 ppm was used for cottonseed; 

a residue of 1.7 ppm was used for sunflower subgroup 20B; a residue of 0.17 ppm was used for 

soybean, seed; a residue of 0.51 ppm was used for vegetable, legume, subgroup 6C, pea and bean 

(except soybean); and a residue of 0.76 ppm was used for rapeseed subgroup 20A (see Table 3).
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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Table 3. Corrected Residues Used in the Chronic Assessment.

Crop Group and/or Commodity Tolerance (ppm)2 Corrected Residue Used in Dietary Assessments

1

Cottonseed Subgroup 20C 0.20 0.34

Sunflower Subgroup 20B 1.0 1.7

Soybean, seed 0.10 0.17

Vegetable, Legume, Subgroup 6C, 

pea and bean (except soybean) 0.30 0.51

Rapeseed Subgroup 20A 0.45 0.76

1 Tolerance level residues were corrected to account for the addition of the M800H02 metabolite which was observed in the 

metabolism studies of preharvest-treated soybean seed. The recommended tolerance level was multiplied by a correction factor 

of 1.7x, where 1.7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression).

2 These are HED-recommended tolerances based on Petitions 0F7744 and 0F7766.

%CT Information: The chronic assessment was based on the assumption of 100% CT for all 

commodities.

Processing Factors: DEEMTM 7.81 default processing factors were used for all processed 

commodities (where provided).

III. Drinking Water Data

The Estimated Drinking Water Concentrations (EDWCs) used in the dietary exposure risk 

assessment were provided by the Environmental Fate and Effects Division (EFED) in a 

memorandum dated 04/15/09 (Memo, G. Orrick; DP# 349860). Water residues were 

incorporated directly into the DEEM-FCIDTM into the food categories “water, direct, all sources” 

and “water, indirect, all sources.”

Screening EDWCs (Table 3) of saflufenacil were generated with FQPA Index Reservoir 

Screening Tool (FIRST) for surface water and with PRZM GW for ground water. Modeled 

application rates represent the maximum use patterns of five proposed end-use labels with 

selected uses on row crops, orchard trees, vineyards, tree plantations, and non-agricultural areas. 

Remaining model input parameters were chosen according to current guidance (USEPA, 2002). 

EDWCs reflect exposure to saflufenacil and all degradates of concern in drinking water (Table 

1). 

Table 3. Tiered EDWCs for Proposed Saflufenacil Uses.

Source (Tier: Model)

1-in-10-year Peak Exposure 

(ppb)

1-in-10-year Annual Mean 

Exposure (ppb)

Surface water (Tier I: FIRST) 37.3 23.8

Ground water (Tier II: PRZM GW) 180

(used in acute analysis)

173

(used in chronic analysis)

IV. DEEM-FCIDTM Program and Consumption Information

Saflufenacil acute and chronic dietary exposure assessments were conducted using DEEMFCIDTM, Version 2.03, which incorporates consumption data from USDA’s CSFII, 1994-1996 

and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (i.e., apple pie) are 

linked to EPA-defined food commodities (i.e. apples, peeled fruit - cooked; fresh or N/S; baked; 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2 years 

old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 years 

old, adults 20-49 years old, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (i.e., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, any 

significant differences in user vs. per capita exposure and risk are specifically identified and 

noted in the risk assessment.

V. Toxicological Information

Table 4. Summary of Toxicological Doses and Endpoints for Saflufenacil for Use in Dietary Human-Health Risk 

Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA SFs

RfD, PAD, 

LOC for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children)

NOAEL = 500 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

Acute RfD =

5.0 mg/kg

aPAD = 5.0 

mg/kg

Acute Neurotoxicity Study.

NOAEL = 500 (M) and 2000 (F) mg/kg/day.

LOAEL was 2000 mg/kg/day (males) based on 

the decreased motor activity representing mild 

and transient systemic toxicity. 

LOAEL was not established for females.

Chronic 

Dietary (All 

Populations)

NOAEL = 4.6 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

Chronic RfD 

= 0.046 

mg/kg/day

cPAD = 0.046 

mg/kg/day

Chronic/Carcinogenicity (mouse).

NOAEL = 4.6 mg/kg bw/d (males) and 18.9 

mg/kg bw/d (females). 

LOAELs = 13.8 mg/kg bw/d (males) and 38.1 

mg/kg bw/day (females) based on decreased 

red blood cells, hemoglobin, and hematocrit 

and porphyria observed in the satellite group.
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Table 4. Summary of Toxicological Doses and Endpoints for Saflufenacil for Use in Dietary Human-Health Risk 

Assessments.

Cancer (oral, 

dermal, 

inhalation)

Classification: Not carcinogenic based on the lack of tumors in the mouse and rat carcinogenicity 

studies and lack of mutagenicity.

NOAEL = no-observed adverse-effect level. LOAEL = lowest-observed adverse-effect level. UF = uncertainty 

factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity among 

members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population-adjusted 

dose (a = acute, c = chronic). RfD = reference dose. LOC = level of concern.

VI. Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 3 are for the general U.S. 

population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12

years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50+ 

years old. 

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary risk for food and drinking water utilized (<1% of the aPAD for the U.S. 

population. The acute dietary risk for the highest exposed population subgroup, all infants (<1 

year old), is <1% of the aPAD at the 95th percentile.

The chronic dietary risk for food and drinking water utilized 9.2% of the cPAD for the U.S. 

population. The chronic dietary risk for the highest exposed population subgroup, all infants (<1 

year old), is 31% of the cPAD. 

The results of the acute and chronic dietary exposure analyses are reported in Table 5. 

Table 5. Summary of Dietary (Food and Drinking Water) Exposure Risk for Saflufenacil.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary

Dietary Exposure 

(mg/kg/day) % aPAD Dietary Exposure(mg/kg/day) % cPAD

General U.S. Population 0.010415 <1 0.004232 9.2

All Infants (<1 year old) 0.038388 <1 0.014043 31

Children 1-2 years old 0.017262 <1 0.007290 16

Children 3-5 years old 0.015438 <1 0.006535 14

Children 6-12 years old 0.010471 <1 0.004383 10

Youth 13-19 years old 0.008451 <1 0.003164 6.9

Adults 20-49 years old 0.009266 <1 0.003821 8.3

Adults 50+ years old 0.008388 <1 0.003959 8.6

Females 13-49 years old 0.009336 <1 0.003802 8.3

*The values for the highest exposed population for each type of risk assessment are bolded.
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VII. Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk estimates are conservative since they assumed 

100% CT, DEEMTM 7.81 default concentration factors, and tolerance-level or higher residues and 

were based on screening level estimates of drinking water concentrations generated by PRZM

GW. They could be further refined through the use of anticipated residues, empirical processing 

factors and % CT data, as well as refined drinking water estimates.

VIII. Conclusions

The acute and chronic dietary exposure and risk analyses using DEEM-FCIDTM indicates that 

dietary risks to saflufenacil from food and drinking water are well below HED’s levels of 

concern for this pesticide. Estimated acute dietary risks are <1% of the aPAD at the 95th

percentile for the general U.S. population and all population subgroups and estimated chronic 

dietary risks are ≤31% of the cPAD for the general U.S. population and all population subgroups. 

IX. List of Attachments

· Acute Food plus Water Residue Input File.

· Acute Results File.

· Chronic Food plus Water Residue Input File.

· Chronic Results File.

cc: G. Kramer (RAB1)

RDI: DESAC (7/18/11)

G.F. Kramer:S10957:PY-S:(703)305-5079:7509P:RAB1
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\##Saflufenacilnew\0E7806\Saflufenacil_Acute.R98

Chemical: Saflufenacil

RfD(Chronic): .046 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 07-14-2011/14:09:07/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

06003470 6 Soybean, seed 0.170000 1.000 1.000 

06003480 6 Soybean, flour 0.170000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.170000 1.000 1.000 

06003490 6 Soybean, soy milk 0.170000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.170000 1.000 1.000 

06003500 6 Soybean, oil 0.170000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.170000 1.000 1.000 

06010430 6A Bean, snap, succulent 0.030000 1.000 1.000 

06010431 6A Bean, snap, succulent-babyfood 0.030000 1.000 1.000 

06012570 6A Pea, edible podded, succulent 0.030000 1.000 1.000 

06020310 6B Bean, broad, succulent 0.030000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 0.030000 1.000 1.000 

06020370 6B Bean, lima, succulent 0.030000 1.000 1.000 

06022550 6B Pea, succulent 0.030000 1.000 1.000 

06022551 6B Pea, succulent-babyfood 0.030000 1.000 1.000 

06022590 6B Pea, pigeon, succulent 0.030000 1.000 1.000 

06030300 6C Bean, black, seed 0.510000 1.000 1.000 

06030320 6C Bean, broad, seed 0.510000 1.000 1.000 

06030340 6C Bean, cowpea, seed 0.510000 1.000 1.000 

06030350 6C Bean, great northern, seed 0.510000 1.000 1.000 

06030360 6C Bean, kidney, seed 0.510000 1.000 1.000 

06030380 6C Bean, lima, seed 0.510000 1.000 1.000 

06030390 6C Bean, mung, seed 0.510000 1.000 1.000 

06030400 6C Bean, navy, seed 0.510000 1.000 1.000 

06030410 6C Bean, pink, seed 0.510000 1.000 1.000 

06030420 6C Bean, pinto, seed 0.510000 1.000 1.000 

06030980 6C Chickpea, seed 0.510000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.510000 1.000 1.000 

06030990 6C Chickpea, flour 0.510000 1.000 1.000 

06031820 6C Guar, seed 0.510000 1.000 1.000 

06031821 6C Guar, seed-babyfood 0.510000 1.000 1.000 

06032030 6C Lentil, seed 0.510000 1.000 1.000 

06032560 6C Pea, dry 0.510000 1.000 1.000 

06032561 6C Pea, dry-babyfood 0.510000 1.000 1.000 

06032580 6C Pea, pigeon, seed 0.510000 1.000 1.000 

10001060 10 Citrus citron 0.030000 1.000 1.000 

10001070 10 Citrus hybrids 0.030000 1.000 1.000 

10001080 10 Citrus, oil 0.030000 1.000 1.000 

10001800 10 Grapefruit 0.030000 1.000 1.000 

10001810 10 Grapefruit, juice 0.030000 2.100 1.000 

10001970 10 Kumquat 0.030000 1.000 1.000 

10001990 10 Lemon 0.030000 1.000 1.000 

10002000 10 Lemon, juice 0.030000 2.000 1.000 

10002001 10 Lemon, juice-babyfood 0.030000 2.000 1.000 

10002010 10 Lemon, peel 0.030000 1.000 1.000 

10002060 10 Lime 0.030000 1.000 1.000 

10002070 10 Lime, juice 0.030000 2.000 1.000 

10002071 10 Lime, juice-babyfood 0.030000 2.000 1.000 

10002400 10 Orange 0.030000 1.000 1.000 

10002410 10 Orange, juice 0.030000 1.800 1.000 

10002411 10 Orange, juice-babyfood 0.030000 1.800 1.000 

10002420 10 Orange, peel 0.030000 1.000 1.000 

10003070 10 Pummelo 0.030000 1.000 1.000 

10003690 10 Tangerine 0.030000 1.000 1.000 

10003700 10 Tangerine, juice 0.030000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.030000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.030000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 10 of 18

11000090 11 Apple, dried 0.030000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.030000 8.000 1.000 

11000100 11 Apple, juice 0.030000 1.300 1.000 

11000101 11 Apple, juice-babyfood 0.030000 1.300 1.000 

11000110 11 Apple, sauce 0.030000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.030000 1.000 1.000 

11001290 11 Crabapple 0.030000 1.000 1.000 

11002100 11 Loquat 0.030000 1.000 1.000 

11002660 11 Pear 0.030000 1.000 1.000 

11002661 11 Pear-babyfood 0.030000 1.000 1.000 

11002670 11 Pear, dried 0.030000 6.250 1.000 

11002680 11 Pear, juice 0.030000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.030000 1.000 1.000 

11003100 11 Quince 0.030000 1.000 1.000 

12000120 12 Apricot 0.030000 1.000 1.000 

12000121 12 Apricot-babyfood 0.030000 1.000 1.000 

12000130 12 Apricot, dried 0.030000 6.000 1.000 

12000140 12 Apricot, juice 0.030000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.030000 1.000 1.000 

12000900 12 Cherry 0.030000 1.000 1.000 

12000901 12 Cherry-babyfood 0.030000 1.000 1.000 

12000910 12 Cherry, juice 0.030000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.030000 1.500 1.000 

12002300 12 Nectarine 0.030000 1.000 1.000 

12002600 12 Peach 0.030000 1.000 1.000 

12002601 12 Peach-babyfood 0.030000 1.000 1.000 

12002610 12 Peach, dried 0.030000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.030000 7.000 1.000 

12002620 12 Peach, juice 0.030000 1.500 1.000 

12002621 12 Peach, juice-babyfood 0.030000 1.500 1.000 

12002850 12 Plum 0.030000 1.000 1.000 

12002851 12 Plum-babyfood 0.030000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.030000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.030000 1.000 1.000 

12002870 12 Plum, prune, dried 0.030000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.030000 5.000 1.000 

12002880 12 Plum, prune, juice 0.030000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.030000 1.400 1.000 

14000030 14 Almond 0.030000 1.000 1.000 

14000031 14 Almond-babyfood 0.030000 1.000 1.000 

14000040 14 Almond, oil 0.030000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.030000 1.000 1.000 

14000590 14 Brazil nut 0.030000 1.000 1.000 

14000680 14 Butternut 0.030000 1.000 1.000 

14000810 14 Cashew 0.030000 1.000 1.000 

14000920 14 Chestnut 0.030000 1.000 1.000 

14001550 14 Filbert 0.030000 1.000 1.000 

14001560 14 Filbert, oil 0.030000 1.000 1.000 

14001850 14 Hickory nut 0.030000 1.000 1.000 

14002130 14 Macadamia nut 0.030000 1.000 1.000 

14002690 14 Pecan 0.030000 1.000 1.000 

14002820 14 Pistachio 0.030000 1.000 1.000 

14003910 14 Walnut 0.030000 1.000 1.000 

15000250 15 Barley, pearled barley 0.030000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.030000 1.000 1.000 

15000260 15 Barley, flour 0.030000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.030000 1.000 1.000 

15000270 15 Barley, bran 0.030000 1.000 1.000 

15000650 15 Buckwheat 0.030000 1.000 1.000 

15000660 15 Buckwheat, flour 0.030000 1.000 1.000 

15001200 15 Corn, field, flour 0.030000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.030000 1.000 1.000 

15001210 15 Corn, field, meal 0.030000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.030000 1.000 1.000 

15001220 15 Corn, field, bran 0.030000 1.000 1.000 

15001230 15 Corn, field, starch 0.030000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.030000 1.000 1.000 

15001240 15 Corn, field, syrup 0.030000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.030000 1.500 1.000 

15001250 15 Corn, field, oil 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 11 of 18

15001251 15 Corn, field, oil-babyfood 0.030000 1.000 1.000 

15001260 15 Corn, pop 0.030000 1.000 1.000 

15001270 15 Corn, sweet 0.030000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.030000 1.000 1.000 

15002260 15 Millet, grain 0.030000 1.000 1.000 

15002310 15 Oat, bran 0.030000 1.000 1.000 

15002320 15 Oat, flour 0.030000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.030000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.030000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.030000 1.000 1.000 

15003230 15 Rice, white 0.030000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.030000 1.000 1.000 

15003240 15 Rice, brown 0.030000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.030000 1.000 1.000 

15003250 15 Rice, flour 0.030000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.030000 1.000 1.000 

15003260 15 Rice, bran 0.030000 1.000 1.000 

15003261 15 Rice, bran-babyfood 0.030000 1.000 1.000 

15003280 15 Rye, grain 0.030000 1.000 1.000 

15003290 15 Rye, flour 0.030000 1.000 1.000 

15003440 15 Sorghum, grain 0.030000 1.000 1.000 

15003450 15 Sorghum, syrup 0.030000 1.000 1.000 

15003810 15 Triticale, flour 0.030000 1.000 1.000 

15003811 15 Triticale, flour-babyfood 0.030000 1.000 1.000 

15004010 15 Wheat, grain 0.030000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.030000 1.000 1.000 

15004020 15 Wheat, flour 0.030000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.030000 1.000 1.000 

15004030 15 Wheat, germ 0.030000 1.000 1.000 

15004040 15 Wheat, bran 0.030000 1.000 1.000 

15004050 15 Wild rice 0.030000 1.000 1.000 

20001630 20 Flaxseed, oil 0.760000 1.000 1.000 

20003190 20 Rapeseed, oil 0.760000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.760000 1.000 1.000 

20003300 20 Safflower, oil 1.700000 1.000 1.000 

20003301 20 Safflower, oil-babyfood 1.700000 1.000 1.000 

20003640 20 Sunflower, seed 1.700000 1.000 1.000 

20003650 20 Sunflower, oil 1.700000 1.000 1.000 

20003651 20 Sunflower, oil-babyfood 1.700000 1.000 1.000 

21000440 M Beef, meat 0.010000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.010000 1.000 1.000 

21000450 M Beef, meat, dried 0.010000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.010000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.010000 1.000 1.000 

21000480 M Beef, kidney 0.050000 1.000 1.000 

21000490 M Beef, liver 2.500000 1.000 1.000 

21000491 M Beef, liver-babyfood 2.500000 1.000 1.000 

23001690 M Goat, meat 0.010000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.010000 1.000 1.000 

23001720 M Goat, kidney 0.050000 1.000 1.000 

23001730 M Goat, liver 2.500000 1.000 1.000 

24001890 M Horse, meat 0.010000 1.000 1.000 

25002900 M Pork, meat 0.010000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.010000 1.000 1.000 

25002910 M Pork, skin 0.010000 1.000 1.000 

25002920 M Pork, meat byproducts 0.020000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

25002930 M Pork, fat 0.010000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.010000 1.000 1.000 

25002940 M Pork, kidney 0.010000 1.000 1.000 

25002950 M Pork, liver 0.800000 1.000 1.000 

26003390 M Sheep, meat 0.010000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.010000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.010000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.010000 1.000 1.000 

26003420 M Sheep, kidney 0.050000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 12 of 18

26003430 M Sheep, liver 2.500000 1.000 1.000 

27002220 D Milk, fat 0.010000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

29003120 M Rabbit, meat 0.010000 1.000 1.000 

86010000 O Water, direct, all sources 0.180000 1.000 1.000 

86020000 O Water, indirect, all sources 0.180000 1.000 1.000 

95000230 O Banana 0.030000 1.000 1.000 

95000231 O Banana-babyfood 0.030000 1.000 1.000 

95000240 O Banana, dried 0.030000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000 

95001150 O Coffee, roasted bean 0.030000 1.000 1.000 

95001160 O Coffee, instant 0.030000 1.000 1.000 

95001280 O Cottonseed, oil 0.340000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.340000 1.000 1.000 

95001750 O Grape 0.030000 1.000 1.000 

95001760 O Grape, juice 0.030000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.030000 1.200 1.000 

95001770 O Grape, leaves 0.030000 1.000 1.000 

95001780 O Grape, raisin 0.030000 4.300 1.000 

95001790 O Grape, wine and sherry 0.030000 1.000 1.000 

95002150 O Mango 0.030000 1.000 1.000 

95002160 O Mango, dried 0.030000 1.000 1.000 

95002170 O Mango, juice 0.030000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.030000 1.000 1.000 

95003360 O Sesame, seed 0.760000 1.000 1.000 

95003361 O Sesame, seed-babyfood 0.760000 1.000 1.000 

95003370 O Sesame, oil 0.760000 1.000 1.000 

95003371 O Sesame, oil-babyfood 0.760000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 13 of 18

Acute Results File.

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for SAFLUFENACIL (1994-98 data)

Residue file: Saflufenacil_Acute.R98 Adjustment factor #2 used.

Analysis Date: 07-14-2011/15:27:20 Residue file dated: 07-14-2011/14:09:07/8

Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

U.S. Population:

 0.010415 0.21 0.019031 0.38 0.037230 0.74 

All infants:

 0.038388 0.77 0.054734 1.09 0.095501 1.91 

Children 1-2 yrs:

 0.017262 0.35 0.028555 0.57 0.040967 0.82 

Children 3-5 yrs:

 0.015438 0.31 0.023025 0.46 0.039569 0.79 

Children 6-12 yrs:

 0.010471 0.21 0.017194 0.34 0.026015 0.52 

Youth 13-19 yrs:

 0.008451 0.17 0.013822 0.28 0.023396 0.47 

Adults 20-49 yrs:

 0.009266 0.19 0.015264 0.31 0.027095 0.54 

Adults 50+ yrs:

 0.008388 0.17 0.011916 0.24 0.019613 0.39 

Females 13-49 yrs:

 0.009336 0.19 0.014984 0.30 0.025487 0.51 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 14 of 18

Chronic Food plus Water Residue Input File.

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\##Saflufenacilnew\0E7806\Saflufenacil_Chronic.R98

Chemical: Saflufenacil

RfD(Chronic): .046 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 03-18-2011/10:48:46/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

06003470 6 Soybean, seed 0.170000 1.000 1.000 

06003480 6 Soybean, flour 0.170000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.170000 1.000 1.000 

06003490 6 Soybean, soy milk 0.170000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.170000 1.000 1.000 

06003500 6 Soybean, oil 0.170000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.170000 1.000 1.000 

06010430 6A Bean, snap, succulent 0.030000 1.000 1.000 

06010431 6A Bean, snap, succulent-babyfood 0.030000 1.000 1.000 

06012570 6A Pea, edible podded, succulent 0.030000 1.000 1.000 

06020310 6B Bean, broad, succulent 0.030000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 0.030000 1.000 1.000 

06020370 6B Bean, lima, succulent 0.030000 1.000 1.000 

06022550 6B Pea, succulent 0.030000 1.000 1.000 

06022551 6B Pea, succulent-babyfood 0.030000 1.000 1.000 

06022590 6B Pea, pigeon, succulent 0.030000 1.000 1.000 

06030300 6C Bean, black, seed 0.510000 1.000 1.000 

06030320 6C Bean, broad, seed 0.510000 1.000 1.000 

06030340 6C Bean, cowpea, seed 0.510000 1.000 1.000 

06030350 6C Bean, great northern, seed 0.510000 1.000 1.000 

06030360 6C Bean, kidney, seed 0.510000 1.000 1.000 

06030380 6C Bean, lima, seed 0.510000 1.000 1.000 

06030390 6C Bean, mung, seed 0.510000 1.000 1.000 

06030400 6C Bean, navy, seed 0.510000 1.000 1.000 

06030410 6C Bean, pink, seed 0.510000 1.000 1.000 

06030420 6C Bean, pinto, seed 0.510000 1.000 1.000 

06030980 6C Chickpea, seed 0.510000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.510000 1.000 1.000 

06030990 6C Chickpea, flour 0.510000 1.000 1.000 

06031820 6C Guar, seed 0.510000 1.000 1.000 

06031821 6C Guar, seed-babyfood 0.510000 1.000 1.000 

06032030 6C Lentil, seed 0.510000 1.000 1.000 

06032560 6C Pea, dry 0.510000 1.000 1.000 

06032561 6C Pea, dry-babyfood 0.510000 1.000 1.000 

06032580 6C Pea, pigeon, seed 0.510000 1.000 1.000 

10001060 10 Citrus citron 0.030000 1.000 1.000 

10001070 10 Citrus hybrids 0.030000 1.000 1.000 

10001080 10 Citrus, oil 0.030000 1.000 1.000 

10001800 10 Grapefruit 0.030000 1.000 1.000 

10001810 10 Grapefruit, juice 0.030000 2.100 1.000 

10001970 10 Kumquat 0.030000 1.000 1.000 

10001990 10 Lemon 0.030000 1.000 1.000 

10002000 10 Lemon, juice 0.030000 2.000 1.000 

10002001 10 Lemon, juice-babyfood 0.030000 2.000 1.000 

10002010 10 Lemon, peel 0.030000 1.000 1.000 

10002060 10 Lime 0.030000 1.000 1.000 

10002070 10 Lime, juice 0.030000 2.000 1.000 

10002071 10 Lime, juice-babyfood 0.030000 2.000 1.000 

10002400 10 Orange 0.030000 1.000 1.000 

10002410 10 Orange, juice 0.030000 1.800 1.000 

10002411 10 Orange, juice-babyfood 0.030000 1.800 1.000 

10002420 10 Orange, peel 0.030000 1.000 1.000 

10003070 10 Pummelo 0.030000 1.000 1.000 

10003690 10 Tangerine 0.030000 1.000 1.000 

10003700 10 Tangerine, juice 0.030000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.030000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.030000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 15 of 18

11000090 11 Apple, dried 0.030000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.030000 8.000 1.000 

11000100 11 Apple, juice 0.030000 1.300 1.000 

11000101 11 Apple, juice-babyfood 0.030000 1.300 1.000 

11000110 11 Apple, sauce 0.030000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.030000 1.000 1.000 

11001290 11 Crabapple 0.030000 1.000 1.000 

11002100 11 Loquat 0.030000 1.000 1.000 

11002660 11 Pear 0.030000 1.000 1.000 

11002661 11 Pear-babyfood 0.030000 1.000 1.000 

11002670 11 Pear, dried 0.030000 6.250 1.000 

11002680 11 Pear, juice 0.030000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.030000 1.000 1.000 

11003100 11 Quince 0.030000 1.000 1.000 

12000120 12 Apricot 0.030000 1.000 1.000 

12000121 12 Apricot-babyfood 0.030000 1.000 1.000 

12000130 12 Apricot, dried 0.030000 6.000 1.000 

12000140 12 Apricot, juice 0.030000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.030000 1.000 1.000 

12000900 12 Cherry 0.030000 1.000 1.000 

12000901 12 Cherry-babyfood 0.030000 1.000 1.000 

12000910 12 Cherry, juice 0.030000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.030000 1.500 1.000 

12002300 12 Nectarine 0.030000 1.000 1.000 

12002600 12 Peach 0.030000 1.000 1.000 

12002601 12 Peach-babyfood 0.030000 1.000 1.000 

12002610 12 Peach, dried 0.030000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.030000 7.000 1.000 

12002620 12 Peach, juice 0.030000 1.500 1.000 

12002621 12 Peach, juice-babyfood 0.030000 1.500 1.000 

12002850 12 Plum 0.030000 1.000 1.000 

12002851 12 Plum-babyfood 0.030000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.030000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.030000 1.000 1.000 

12002870 12 Plum, prune, dried 0.030000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.030000 5.000 1.000 

12002880 12 Plum, prune, juice 0.030000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.030000 1.400 1.000 

14000030 14 Almond 0.030000 1.000 1.000 

14000031 14 Almond-babyfood 0.030000 1.000 1.000 

14000040 14 Almond, oil 0.030000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.030000 1.000 1.000 

14000590 14 Brazil nut 0.030000 1.000 1.000 

14000680 14 Butternut 0.030000 1.000 1.000 

14000810 14 Cashew 0.030000 1.000 1.000 

14000920 14 Chestnut 0.030000 1.000 1.000 

14001550 14 Filbert 0.030000 1.000 1.000 

14001560 14 Filbert, oil 0.030000 1.000 1.000 

14001850 14 Hickory nut 0.030000 1.000 1.000 

14002130 14 Macadamia nut 0.030000 1.000 1.000 

14002690 14 Pecan 0.030000 1.000 1.000 

14002820 14 Pistachio 0.030000 1.000 1.000 

14003910 14 Walnut 0.030000 1.000 1.000 

15000250 15 Barley, pearled barley 0.030000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.030000 1.000 1.000 

15000260 15 Barley, flour 0.030000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.030000 1.000 1.000 

15000270 15 Barley, bran 0.030000 1.000 1.000 

15000650 15 Buckwheat 0.030000 1.000 1.000 

15000660 15 Buckwheat, flour 0.030000 1.000 1.000 

15001200 15 Corn, field, flour 0.030000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.030000 1.000 1.000 

15001210 15 Corn, field, meal 0.030000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.030000 1.000 1.000 

15001220 15 Corn, field, bran 0.030000 1.000 1.000 

15001230 15 Corn, field, starch 0.030000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.030000 1.000 1.000 

15001240 15 Corn, field, syrup 0.030000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.030000 1.500 1.000 

15001250 15 Corn, field, oil 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

______________________________________________________________________________________

Page 16 of 18

15001251 15 Corn, field, oil-babyfood 0.030000 1.000 1.000 

15001260 15 Corn, pop 0.030000 1.000 1.000 

15001270 15 Corn, sweet 0.030000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.030000 1.000 1.000 

15002260 15 Millet, grain 0.030000 1.000 1.000 

15002310 15 Oat, bran 0.030000 1.000 1.000 

15002320 15 Oat, flour 0.030000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.030000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.030000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.030000 1.000 1.000 

15003230 15 Rice, white 0.030000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.030000 1.000 1.000 

15003240 15 Rice, brown 0.030000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.030000 1.000 1.000 

15003250 15 Rice, flour 0.030000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.030000 1.000 1.000 

15003260 15 Rice, bran 0.030000 1.000 1.000 

15003261 15 Rice, bran-babyfood 0.030000 1.000 1.000 

15003280 15 Rye, grain 0.030000 1.000 1.000 

15003290 15 Rye, flour 0.030000 1.000 1.000 

15003440 15 Sorghum, grain 0.030000 1.000 1.000 

15003450 15 Sorghum, syrup 0.030000 1.000 1.000 

15003810 15 Triticale, flour 0.030000 1.000 1.000 

15003811 15 Triticale, flour-babyfood 0.030000 1.000 1.000 

15004010 15 Wheat, grain 0.030000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.030000 1.000 1.000 

15004020 15 Wheat, flour 0.030000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.030000 1.000 1.000 

15004030 15 Wheat, germ 0.030000 1.000 1.000 

15004040 15 Wheat, bran 0.030000 1.000 1.000 

15004050 15 Wild rice 0.030000 1.000 1.000 

20001630 20 Flaxseed, oil 0.760000 1.000 1.000 

20003190 20 Rapeseed, oil 0.760000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.760000 1.000 1.000 

20003300 20 Safflower, oil 1.700000 1.000 1.000 

20003301 20 Safflower, oil-babyfood 1.700000 1.000 1.000 

20003640 20 Sunflower, seed 1.700000 1.000 1.000 

20003650 20 Sunflower, oil 1.700000 1.000 1.000 

20003651 20 Sunflower, oil-babyfood 1.700000 1.000 1.000 

21000440 M Beef, meat 0.010000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.010000 1.000 1.000 

21000450 M Beef, meat, dried 0.010000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.010000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.010000 1.000 1.000 

21000480 M Beef, kidney 0.050000 1.000 1.000 

21000490 M Beef, liver 2.500000 1.000 1.000 

21000491 M Beef, liver-babyfood 2.500000 1.000 1.000 

23001690 M Goat, meat 0.010000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.010000 1.000 1.000 

23001720 M Goat, kidney 0.050000 1.000 1.000 

23001730 M Goat, liver 2.500000 1.000 1.000 

24001890 M Horse, meat 0.010000 1.000 1.000 

25002900 M Pork, meat 0.010000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.010000 1.000 1.000 

25002910 M Pork, skin 0.010000 1.000 1.000 

25002920 M Pork, meat byproducts 0.020000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

25002930 M Pork, fat 0.010000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.010000 1.000 1.000 

25002940 M Pork, kidney 0.010000 1.000 1.000 

25002950 M Pork, liver 0.800000 1.000 1.000 

26003390 M Sheep, meat 0.010000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.010000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.010000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.010000 1.000 1.000 

26003420 M Sheep, kidney 0.050000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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Page 17 of 18

26003430 M Sheep, liver 2.500000 1.000 1.000 

27002220 D Milk, fat 0.010000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

29003120 M Rabbit, meat 0.010000 1.000 1.000 

86010000 O Water, direct, all sources 0.173000 1.000 1.000 

86020000 O Water, indirect, all sources 0.173000 1.000 1.000 

95000230 O Banana 0.030000 1.000 1.000 

95000231 O Banana-babyfood 0.030000 1.000 1.000 

95000240 O Banana, dried 0.030000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000 

95001150 O Coffee, roasted bean 0.030000 1.000 1.000 

95001160 O Coffee, instant 0.030000 1.000 1.000 

95001280 O Cottonseed, oil 0.340000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.340000 1.000 1.000 

95001750 O Grape 0.030000 1.000 1.000 

95001760 O Grape, juice 0.030000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.030000 1.200 1.000 

95001770 O Grape, leaves 0.030000 1.000 1.000 

95001780 O Grape, raisin 0.030000 4.300 1.000 

95001790 O Grape, wine and sherry 0.030000 1.000 1.000 

95002150 O Mango 0.030000 1.000 1.000 

95002160 O Mango, dried 0.030000 1.000 1.000 

95002170 O Mango, juice 0.030000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.030000 1.000 1.000 

95003360 O Sesame, seed 0.760000 1.000 1.000 

95003361 O Sesame, seed-babyfood 0.760000 1.000 1.000 

95003370 O Sesame, oil 0.760000 1.000 1.000 

95003371 O Sesame, oil-babyfood 0.760000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 390923

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Page 18 of 18

Chronic Results File.

.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL (1994-98 data)

Residue file name: C:\Documents and Settings\gkramer\My Documents\Gk\##Saflufenacilnew\0E7806\Saflufenacil_Chronic.R98

 Adjustment factor #2 used.

Analysis Date 07-14-2011/14:09:51 Residue file dated: 07-14-2011/14:07:35/8

Reference dose (RfD, Chronic) = .046 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

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 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.004232 9.2%

U.S. Population (spring season) 0.004195 9.1%

U.S. Population (summer season) 0.004498 9.8%

U.S. Population (autumn season) 0.004115 8.9%

U.S. Population (winter season) 0.004116 8.9%

Northeast region 0.003915 8.5%

Midwest region 0.004270 9.3%

Southern region 0.004020 8.7%

Western region 0.004814 10.5%

Hispanics 0.004896 10.6%

Non-hispanic whites 0.004107 8.9%

Non-hispanic blacks 0.004075 8.9%

Non-hisp/non-white/non-black 0.005158 11.2%

All infants (< 1 year) 0.014043 30.5%

Nursing infants 0.005194 11.3%

Non-nursing infants 0.017401 37.8%

Children 1-6 yrs 0.006649 14.5%

Children 7-12 yrs 0.004146 9.0%

Females 13-19 (not preg or nursing) 0.003045 6.6%

Females 20+ (not preg or nursing) 0.004018 8.7%

Females 13-50 yrs 0.003997 8.7%

Females 13+ (preg/not nursing) 0.004046 8.8%

Females 13+ (nursing) 0.005640 12.3%

Males 13-19 yrs 0.003256 7.1%

Males 20+ yrs 0.003690 8.0%

Seniors 55+ 0.003953 8.6%

Children 1-2 yrs 0.007290 15.8%

Children 3-5 yrs 0.006535 14.2%

Children 6-12 yrs 0.004383 9.5%

Youth 13-19 yrs 0.003164 6.9%

Adults 20-49 yrs 0.003821 8.3%

Adults 50+ yrs 0.003959 8.6%

Females 13-49 yrs 0.003802 8.3%

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