|  [X] | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|-----------|--------------------------------------------------------------------------------------|

|  [  ] | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|-----------------|------------------------------------------------------------------------------------------|

| Tengion, Inc.(Exact name of registrant as specified in its charter)                                                                                                                   |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Delaware(State or other jurisdiction ofincorporation or organization)                                                                                                                      | 20-0214813(I.R.S. Employer Identification No.)  |
|  3929 Westpoint Boulevard, Suite GWinston-Salem, NC 27103(Address of principal executive offices) (336) 722-5855(Registrant’s telephone number, including area code)  |

| Title of each Class                            |  Name of Exchange on which registered |
|------------------------------------------------|--------------------------------------------|
|  Common Stock, par value $0.001 per share | NASDAQ Global Market                       |

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| EXPLANATORY NOTE                  | 1      |
|-----------------------------------|--------|
|                              |   |
| PART II – OTHER INFORMATION |   |
| Item 6.  Exhibits       | 2      |
|                              |   |
| SIGNATURES                        | 3      |

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EXPLANATORY 

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PART 

| Item 6. | EXHIBITS |
|---------|----------|

|   | (a)  Exhibits |
|--------|-------------------------|

| Exhibit No. | Description_____________________________________________________________________ |
|-------------|----------------------------------------------------------------------------------|

| 31.1 | Certification of John L. Miclot, President and Chief Executive Officer of the Registrant, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (Rule 13a-14(a)/15d-14(a) certification). |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 31.2 | Certification of A. Brian Davis, Chief Financial Officer and Vice President of Finance of the Registrant, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (Rule 13a-14(a)/15d-14(a) certification). |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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SIGNATURES

|                             | TENGION, INC. |
|----------------------------------|---------------|
|                             |          |   |
|                             |          |   |
| Date:  January 9, 2013 | By:           | /s/ John L. Miclot |
|                             |          | John L. Miclot |
|                             |          | President and Chief Executive Officer |

| Signature                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              | Title                                                                                                    | Date            |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------|-----------------|
| /s/ John L. Miclot                                                      John L. Miclot                                                                                                                                              | President and Chief Executive Officer, Director (Principal Executive Officer)                       | January 9, 2013 |
| /s/ A. Brian Davis                                                      A. Brian Davis                                                                                                                                              | Chief Financial Officer and Vice President of Finance (Principal Financial and Accounting Officer)  | January 9, 2013 |
|                        *                                                      David I. Scheer                    | Chairman of the Board of Directors                                                                       | January 9, 2013 |
|                        *                                                      Carl-Johan Dalsgaard, M.D., Ph.D.  | Director                                                                                                 | January 9, 2013 |
|                        *                                                      Diane K. Jorkasky, M.D.            | Director                                                                                                 | January 9, 2013 |
|                        *                                                      Richard E. Kuntz, M.D., M.Sc.      | Director                                                                                                 | January 9, 2013 |
|                        *                                                      Lorin J. Randall                        | Director                                                                                                 | January 9, 2013 |

| * By:  | /s/ A. Brian Davis |   |
|--------|--------------------|--------|
|   | A. Brian Davis     |   |
|   | Attorney-in-fact   |   |

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