# Patent

## Title
Substituted tetrazolinones and herbicidal compositions thereof

## Abstract

There is disclosed imidazolesulfonamide derivatives represented by the general formula (I): ##STR1## wherein Q, m, R, B, D and T represent a group as specified in the specification and

## Background
This invention relates to a novel imidazolesulfonamide derivative, a process for preparing the compound and a herbicide containing the compound as an active ingredient.

In order to protect important crops such as rice plants, wheat, corn, soybean, cotton, beat, etc. from damages by weeds to achieve an increased yield, it is indispensable to use a herbicide. In recent years in particular, a herbicide having selectivity (or discriminativity) is sought after as it can kill only weeds selectively without damages to crops even when a foliage treatment with the herbicide is applied simultaneously on crops and weeds in a cultivated land wherein useful crops and weeds are grown together. Also, from viewpoints of prevention of environmental pollution, the transportation, and the economical cost reduction in application of chemicals, studies and researches have been made over many years on such compounds that may achieve a higher herbicidal activity with use of chemicals in a lower amount. Some of the compounds having such a property are presently used as the herbicide having selectivity. Still, however, there are further demands for new compounds having such a property.

The present inventors have made researches over many years to develop herbicides having the selectivity on important crops, and have examined herbicidal properties of a number of compounds to create compounds having a higher herbicidal effect and the selectivity. As a result, it was found that an imidazolesulfonamide derivative represented by general Formula (I) (hereinafter referred to as "the compound of this invention): ##STR2## wherein Q represents a group of; ##STR3## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a halogenated lower alkyl group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a group of NR.sup.12 R.sup.13, a lower alkoxy group, a group of SO.sub.2 NR.sup.8 R.sup.9, a group of SO.sub.2 OR.sup.11 or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group and a lower alkyl group); atom, a lower alkyl group, a halogenated loweralkyl group, a nitro group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a lower alkoxy group or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a group of COOR.sup.10, a nitro group, a lower alkoxy group and a lower alkyl group); atom, a lower alkyl group, a lower alkoxy group, a nitro group or a group of COOR.sup.10 ; alkyl group or a phenyl group; ; or 2; and lower alkyl group, nitro group, a lower alkyl group, an aralkyl group, a lower alkoxy group, a halogenated alkyl group, a halogenated alkenyl group, a lower alkoxyalkyl group, an alkylcarbonyl group, a group of COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21 , a hydroxy group, a benzoyl group which may be substituted (the substituent is selected from a halogen atom and a lower alkyl group) or a phenyl group which may substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group and a lower alkyl group); substituted (the substituent is selected from a lower alkoxy group which may be substituted by a group of OR.sup.10, a halogen atom, a halogenated lower alkoxy group, a cyano group, a phenoxy group, a lower alkoxycarbonyl group, a group of NR.sup.10 R.sup.11, a lower cycloalkyl group, a lower alkylthio group and a lower alkylcarbonyl group), a lower alkenyl group, a halogenated lower alkenyl group, a lower alkynyl group, a halogenated lower alkynyl group, a halogenated lower cycloalkyl group or a benzyl group; and R.sup.16 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; group, a halogenated alkyl group, a lower alkenyloxy group or a lower alkynyloxy group; and n represents an integer of 0, 1 or 2; alkyl group, a lower alkylcarbonyl group or a lower alkylsulfonyl group; alkyl group, a lower alkenyl group or a lower alkynyl group; ##STR4## E represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower alkoxy group; ##STR5## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkoxyalkyl group, a halogenated alkyl group, a halogenated lower alkoxy group, a group of NR.sup.24 R.sup.25, a group of OCH(R.sup.10)COOR.sup.10, a group of COOR.sup.10, a cyclopropyl group, a group of CH(OR.sup.26).sub.2, a lower alkylthio group or a halogenated lower alkylthio group, lower alkyl group or a lower alkoxy group; atom, a lower alkyl group, a halogenated alkyl group or a lower alkoxy group; alkoxy group, and Y.sup.2 represents a lower alkyl group; lower alkyl group, a halogen atom, a lower alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ; alkoxyalkyl group or a halogen atom; atom, a monoalkylamino group or a dialkylamino group; group, a group of S(O).sub.n R.sup.11, an alkyl group or a halogenated alkyl group; lower alkoxy group; (wherein R.sup.28 represents a hydrogen atom or a lower alkoxy group); imidazolynyl group, a pyrazolyl group, a triazolyl group or a benzimidazolyl group each of which may be mono-, di- or tri-substituted by a lower alkyl group; ##STR6## wherein Q, R, m, B and D have the same meanings as defined above; and R.sup.23 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group,

has a strong herbicidal effect to various weeds while retaining high safety to the important crops in either case of the soil treatment or the foliage treatment, whereby this invention has been accomplished. The compound of this invention shows a high herbicidal activity in an application of a very low amount of the active ingredient as compared with the conventional herbicides, and accordingly it is useful also as a herbicide for orchards and uncultivated lands.

As a prior technique, for example, Japanese Provisional Patent Publication No. 162587/1983 and No. 1480/1984 disclose imidazolesulfonylurea which has the structure similar to the compound of this invention. However, there has been disclosed no compound wherein a heterocyclic ring is substituted on an imidazole ring as the compound of this invention. Thus, the compound of this invention can be said to be a novel one.

In the present invention, preferred componds represented by the formula (I) are as follows: ##STR7## wherein R.sub.1 represents a hydrogen atom, a methyl group, a halogen atom or a nitro group; R represents a methyl group or an ethyl group; Q is selected from the group of Q5, Q6, Q7, Q9, Q15, Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68, Q88, Q127, Q138Q142, Q188, Q189, Q201, Q202, Q204, Q205, Q209, Q222, Q225, Q229, Q230, Q246 and Q250 as mentioned on pages 45 to 57 hereinbelow; group; and Z is --CH.dbd. or --N.dbd..

The compound of this invention, represented by general formula (I) can be readily prepared by selecting any of reaction schemes 1 to 7 shown below. ##STR8## wherein B, D, E, G, Q, R, W.sup.2 and m have the same meanings as defined above.

More specifically, the imidazolesulfonyl(thio)isocyanate derivative (II) is dissolved in a sufficiently dried inert solvent such as dioxane and acetonitrile and thereto is added a pyrimidine, triazine or triazole derivative represented by Formula (III), with stirring. Thus, the reactants generally are reacted with each other rapidly to give the compound (I)' which is part of the compound of this invention. In cases where it is difficult for the reaction to proceed, a trace or small amount of suitable base, such as triethylamine, triethylenediamine, pyridine, a sodium alkoxide, sodium hydride and the like, may be added to the reaction system to allow the reaction to proceed readily. ##STR9## wherein B, D, E, G, Q, R, W.sup.2 and m have the same meanings as defined above. R.sup.29 represents a lower alkyl group or a phenyl group.

More specifically, the imidazolesulfonamide derivative (V) is reacted with a chloroformic acid (thio)ester or a carbonic acid (thio)ester in a solvent such as acetone, methyl ethyl ketone and acetonitrile in the presence of a base such as potassium carbonate to give the compound (IV). Subsequently, the resulting (IV) is heated with the compound (III) in a solvent such as tolune to give the compound (I)' which is a part of the compound of this invention. ##STR10## wherein B, D, E, G, Q, R, W.sup.2 and m have the same meanings as defined above. R.sup.29 represents a lower alkyl group or a phenyl group.

More specifically, by reacting the imidazolesulfonamide derivative (V) with an N-heterocylic carbamate (III)' in the presence of an inorganic salts such as hydroxides, hydrides, etc., or an organic bases such as alkylamine, pyridine, 1,8-diazabicyclo(5.4.0)-7-undecene in an inert solvent such as methylene chloride, tetrahydrofuran, acetonitrile, etc., the compound (I)' which is a part of the compound of this invention can be obtained. ##STR11## wherein B, D, E, G, Q, R, m, R.sup.22 and R.sup.23 have the same meanings as defined above. ##STR12## wherein Az, B, D, E, G, Q, R, W.sup.2, m, R.sup.22 and R.sup.23 have the same meanings as defined above. ##STR13## wherein Az, B, D, E, G, Q, R and m have the same meanings as defined above.

More specifically, the above imidazolesulfonamide derivative in any of Reaction schemes 4 to 6, which is a part of the compound of this invention can be synthesized in accordance with the process disclosed in Japanese Provisional Patent Publications No. 167570/1984, No. 6654/1985, No. 36467/1985, No. 60670/1986, No. 60684/1986 and No. 72783/1986. ##STR14## wherein B, D, E, G, Q, R, W and m have the same meanings as defined above; and Hal represents a halogen atom.

More specifically, 1H-imidazolesulfonylurea is reacted with a Hal--(CHR).sub.m --Q in the presence of an appropriate base to give the compound (I)' which is a part of the compound of this invention. Be noted that in case where m is 0, Q desirably has an electron attractive group such as a nitro group, CF.sub.3, a halogen atom or the like as a substituent therefor in many occasions and the Hal-group is required to have high reactivity.

The starting material, the imidazolesulfonyl(thio)isocyanate (II) or the imidazolesulfonyl(thio)carbamate derivative (IV) which is used in Reaction schemes 1 and 2 may be synthesized by optionally selecting the methods as will be described hereinafter to synthesize the imidazolesulfonamide (V) and further converting the resulting product to the desired product with reference to the methods as described in European Patent Publication No. 87,780 (EP-A0 087 780) and Japanese Provisional Patent Publication No. 13266/1980.

The imidazolesulfonamide which is an intermediate to be used in the present invention is also a novel compound, which can be obtained by optionally selecting one of the following Reaction schemes 8 to 12 and the methods described in Japanese Provisional Patent Publications No. 162587/1983, No. 1480/1984, etc. ##STR15##

(a) NaNO.sub.2.HCl or NaNO.sub.2.HBr

(b) SO.sub.2.Cu salt

(c) NH.sub.4 OH or ammonium carbonate

(d) Cu salt

(e) NaSH

(f) NaOH.NH.sub.4 OH/NaOCl

(g) Oxidizing agent

(h) NaSCH.sub.2 Ph

(i) Cl.sub.2 /CH.sub.3 CO.sub.2 H.H.sub.2 O or NaOCl/HCl

(j)

(k)

(l) Q--(CHR).sub.m --Hal/base

In Reaction schemes 8 to 12, B, D, Q, R and m have the same meanings as defined above; and Hal represents a halogen atom.

The imidazolesulfonamide (V) may usually be obtained by reacting a corresponding imidazolesulfonyl chloride with an aqueous ammonia or ammonium carbonate. In order to introduce a sulfonyl group into an imidazole ring, there may be adopted such methods as follows:

(1) The amino group is subjected to diazonium decomposition in the presence of sulfur dioxide to give a imidazolesulfonyl chloride;

(2) A sulfur atom is introduced into the imidazole ring by a nucleophilic substitution reaction with a halogen atom or the like and optionally the resulting compound is further oxidized to given an imidazolesulfonyl chloride;

(3) A carbanion of an imidazole is formed by using a base and sulfur dioxide is reacted therewith followed by halogenation to give an imidazolesulfonyl chloride; and

(4) Chlorosulfonic acid or the like is used to directly give an imdazolesulfonyl chloride in an electrophilic substitution reaction.

More specifically, (1) according to Reaction scheme 8, an aminoimidazole is converted into a diazonium salt by using sodium nitrite or the like in hydrochloric acid, hydrobromic acid or the like and then sulfur dioxide is reacted with the resulting diazonium salt in the presence of a catalyst which is usually used for diazonium decomposition such as a copper salt or the like, to afford a corresponding imidazolesulfonyl chloride. With the resulting compound was reacted an aqueous ammonia to give the desired pyrazolesulfonamide (V).

(2) According to Reaction scheme 9, a halogenated imidazole is treated with sodium hydrosulfide, sodium salt of benzylmercaptan or the like to introduce a sulfur atom into the imidazole ring, followed by oxidation with chlorine in a solvent such as acetic acid/water to give an imidazolesulfonyl chloride. As in Reaction scheme 8, a reaction with an aqueous ammonia gives the desired pyrazolesulfonamide (V). The desired imidazolesulfonamide may also be obtained by converting the intermediate of mercaptopyrazole into a sulfenamide which is then oxidized. The starting material, the halogenated imidazole, may be obtained by diazo-decomposition of an aminopyrazole; by the reaction of a hydroxyimidazole with phosphorus oxychloride or phosphorus oxybromide; or by formation of an anion by using a strong base such as butyl lithium, lithium diisopropylamide or the like, followed by halogenation.

(3) According to Reaction scheme 11, an anion may be formed by using a strong base such as butyl lithium, lithium diisopropylamide or the like, and the resulting anion may further be treated with sulfur dioxide and subsequently with an N-halogenosuccinimide to form an imidazolesulfonyl chloride which is then treated with an aqueous ammonia to give the desired imidazolesulfonamide (V).

(4) According to Reaction scheme 10, use of chlorosulfonic acid may give directly an imidazolesulfonyl chloride.

In addition to the above schemes, according to Reaction scheme 12, the desired imidazolesufonamide (V) may be obtained by allowing an imidazolesulfonamide having no substituent on the 1-position to react with an appropriate halogen derivative Hal--(CHR).sub.m --Q (wherein Q, R, m and Hal have the same meanings as defined above) in the presence of a suitable base. The reaction may be carried out in accordance with Reaction scheme 7. In reactions in Reaction schemes 10 to 12, isomers may possibly be formed in admixture with the desired compound depending upon occasion. However, such isomers may be separated by recrystallization, column chromatography or the like and used as an intermediate for the compound of this invention. General literatures for the chemistry on the imidazoles used as starting materials in the above-mentioned reactions include the following ones. M. R. Grimmett, Advanced Heterocyclic Chemistry, Vol. 12, p. 104 (1970); R. C. Elderfield, Heterocyclic Compounds, Vol. V, p. 194 (1957), published by John Wiley and Sons, Inc., New York; K. Schofield, M. R. Grimmett and B. R. T. Keene, Heteroaromatic Nitrogen Compounds The Azoles, published by Cambridge University Press, (1976); M. R. Grimmett, Comprehensive Heterocyclic Chemistry, Vol. 5, p. 345 (1984), published by Pergamon Press.

The mercaptoimidazole derivative, for example, may be synthesized, as shown in Reaction scheme 13, according to methods described in R. G. Jones, E. C. Kornfeld, K. C. McLaughlin and R. C. Anderson, J. Am. Chem. Soc., Vol. 71, p. 4000 (1949). ##STR16## wherein Q, R, R.sup.11 and m have the same meanings as defined above; and B and D each independently represent a hydrogen atom or a lower alkyl group. ##STR17## wherein Q, R, R.sup.11, W.sup.2, m and Hal have the same meanings as defined above; B represents a hydrogen atom, a lower alkyl group or a lower alkylmercapto group; D represents an alkylcarbonyl group, a benzoyl group, a cyano group, an alkylsulfonyl group, a phenylsulfonyl group, a group of COOR.sup.14 or a group of CONR.sup.15 R.sup.16 ; wherein R.sup.14, R.sup.15 and R.sup.16 have the same meanings as defined above. ##STR18## wherein Q, R, R.sup.11 and m have the same meanings as defined above; B represents a hydrogen atom or a lower alkyl group; D represents a hydrogen atom, an alkylcarbonyl group, a benzoyl group, a cyano group, an alkylsulfonyl group, a phenylsulfonyl group, a group of COOR.sup.14 or a group of CONR.sup.15 R.sup.16, in which R.sup.14, R.sup.15 and R.sup.16 have the same meanings as defined above.

An aminoimidazole may be synthesized, as shown in Reaction scheme 14, according to methods described in K. Gewald and G. Heinhold, Monatsh. Chem., Vol. 107, p. 1413 (1976), specification of East German Pat. No. 118,640 and A. Edenhofer, Helv. Chim. Acta., Vol. 58, p. 2192 (1975) to give 4-aminoimidazole derivatives having various substituents. Also, 5-aminoimidazole may be synthesized, as shown in Reaction scheme 15, according to methods described in D. H. Robinson and G. Shaw, J. Chem. Soc., Perkin Trans. I, p. 1715 (1972).

Further, a heterocyclic isothiocyanate which is a raw material to be used in a reaction of Reaction scheme 13 may be synthesized, for example as shown in Reaction scheme 16, according to methods desribed in D. J. LeCount, D. J. Dewsbury and W. Grundy, Synthesis, p. 582 (1977). ##STR19## wherein Q, R and m have the same meanings as defined above.

Generally, a person skilled in the art would be able to obtain an intermediate for the compound of the present invention by investigating experimental conditions and the like taking into consideration the above descriptions and the prior art technologies as mentioned above. Hereinafter, there will be described Synthesis examples of the present compounds and the intermediate imidazolesulfonamide therefor by way of Examples or Reference examples, which, however, should not be construed to limit the present invention.

To a mixture of 29.1 g of 3-amino-1-methylpyrazole and 45 ml of triethylamine was added dropwise 18 ml of carbon disulfide and the resulting mixture was stirred at 40.degree. C. for 30 minutes to precipitate solids. To the reaction mixture was added ether, followed by pulverization of solids. After filtration, the thus pulverized solids were washed with ether to give 67 g of triethylamine salt of 1-methyl-3-pyrazolyldithiocarbamic acid (melting point: 79.degree. to 82.degree. C.) 31.8 g of the thus obtained triethylamine salt of dithiocarbamic acid and 11.7 g of triethylamine were dissolved in 150 ml of methylene chloride. To the resulting solution was added at one time 34.5 g of ferric chloride 6 hydrate dissolved in 100 ml of water, followed by vigorous stirring for 10 minutes. The reaction mixture was filtered to remove insoluble solids. The organic layer was separated and then the aqueous layer was extracted with methylene chloride. After the organic layers were combined, washed with water and dried, the solvent was distilled off under reduced pressure. To the thus obtained residue was added ether to filter the insoluble solids off and the filtrate was concentrated under reduced pressure to give 9.0 g of oil. The thus obtained oil was evaporated under reduced pressure to give 6.5 g of the desired compound. b.p.: 135.degree. to 138.degree. C./23 mmHg.

To 6.6 g of 2,2-diethoxyethylamine dissolved in 100 ml of ethanol was added 6.3 g of 1-methyl-3-pyrzolylisothiocyanate, followed by stirring at room temperature over night. Crystals precipitated were filtered out and washed with a small amount of ethanol to give 10.3 g of N-2,2-diethoxyethyl-N'-(1-methylpyrazol-3-yl)thiourea (m.p.: 152.degree. to 155.degree. C.). 10.0 g of the crystals thus obtained were suspended in 70 ml of water. To the resulting suspension was added 15 ml of conc. hydrochloric acid, followed by stirring under reflux with heating for 30 minutes. The reaction mixture was cooled and adjusted to pH to 4 to 6 with use of 50% aqueous sodium hydroxide solution to precipitate crystals. The crystals precipitated were filtered out, washed with water and dried to give 6.0 g of the desired compound. m.p.: 126.degree. to 128.degree. C.

To a mixture of 5.8 g of 1-(1-methylpyrazol-3-yl)imidazole-2-thiol, 30 ml of water, 60 ml of chloroform and 27 g of conc. hydrochloric acid was added dropwise 192 g of aqueous sodium hypochlorite solution (content of 6%) under vigorous stirring at -10.degree. to 0.degree. C. over about 4 hours. After completion of the dropwise addition, the resulting mixture was stirred at the same temperature for 1 hour. Then, the organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined and washed with water. Then, to the organic layer was added dropwise 20 ml of 28% aqueous ammonia under ice-cooling, followed by stirring at room temperature for 1.5 hours. Crystals precipitated by concentrating the resulting mixture under reduced pressure, were filtered out, washed with water and subsequently with ether to give 2.9 g of the desired compound. m.p.: 208.degree. to 210.degree. C.

Using 5-amino-1-methylpyrazole as a starting material, triethylamine salt of 1-methyl-5-pyrazolyldithiocarbamic acid (m.p.: 89.degree. to 94.degree. C.) was synthesized, following the procedures described in Reference Example 1. Ferric chloride was allowed to act upon the resulting product to yield the desired compound. Oily substance.

Using 1-methyl-5-pyrazolylisothiocyanate as a starting material, the desired compound was obtained via N-2,2-diethoxyethyl-N'-(1-methylpyrazol-5-yl)thiourea (m.p.: 148.degree. to 149.degree. C.) as an intermediate, following the procedures described in Reference Example 2. m.p.: 247.degree. to 251.degree. C.

To a mixture of 5.0 g of 1-(1-methylpyrazol-5-yl)imidazole-2-thiol, 30 ml of water, 60 ml of chloroform and 23 g of conc. hydrochloric acid, was added dropwise 100 g of aqueous sodium hypochlorite (content of 6%) under vigorous stirring at -10.degree. to 0.degree. C. over 2.5 hours. After completion of the dropwise addition, the resulting mixture was stirred at the same temperature for 0.5 hour. Then the organic layer was separated and the aqueous layer was extracted with chloroform. After the organic layers were combined and washed with water, to the organic layer was added dropwise 20 ml of 28% aqueous ammonia under ice-cooling, followed by stirring at room temperature for 1.5 hours. Crystals precipitated by concentrating the resulting mixture under reduced pressure, were filtered out, washed with water and subsequently with ether to give 3.4 g of the desired compound. m.p.: 230.degree. to 233.degree. C.

In 200 ml of acetonitrile, 6.7 g of ethyl-aminocyanoacetate, 8.5 g of ethyl orthoformate and 5.6 g of 3-amino-1-methylpyrazole were refluxed under heating for 4.5  hours. After completion of the reaction, the solvent was distilled off under reduced pressure. Crystals precipitated was filtered out, followed by washing with ether to give 7.5 g of the desired compound. m.p.: 168.degree. to 170.degree. C.

7.4 g of 5-amino-4-ethoxycarbonyl-1-(1-methylpyrazol-3-yl)imidazole was dissolved in 40 ml of conc. hydrochloric acid and the resulting solution was cooled to -5.degree. C. Subsequently, 2.6 g of sodium nitrite was dissolved in 10 ml of water and the resulting solution was added dropwise to the previously prepared solution while maintaining the temperature at -5.degree. C. or lower. After completion of the dropwise addition, the resulting mixture was stirred at the same temperature for 0.5 hour. The thus obtained solution was added dropwise at around 5.degree. C. to 120 ml of a solution of chloroform containing 0.5 g of cuprous chloride and 17 g of sulfur dioxide. After the resulting mixture was stirred at room temperature for 1 hour, was added thereto 200 ml of water and the organic layer was separated. The aqueous layer was extracted with chloroform and the organic layers were combined, washed with water and dried. The solvent was then removed by distillation to give 8.0 g of 5-chloro-6-ethoxycarbonyl-1-(1-methylpyrazol- 3-yl)imidazole as an oil. 1-(4-chloro-1-methylpyrazol-3-yl)-4-ethoxycarbonylimidazole-5-sulfonamide

7.5 g of 5-chloro-4-ethoxycarbonyl-1-(1-methylpyrazol-3-yl)imidazole was dissolved in 30 ml of dimethylformamide. To the resulting solution was added 5.9 g of sodium hydrosulfide (content of 70%), followed by stirring of the resulting mixture at 70.degree. to 80.degree. C. for 1.5 hours. After completion of the reaction, 100 ml of ice-cold water was added to the reaction mixture and the resulting mixture was made weakly acidic with use of conc. hydrochloric acid. Subsequently, 100 ml of chloroform was added to the mixture and chlorine was introduced into the resulting mixture little by little at -10.degree. to 0.degree. C. over 2 hours. After completion of the reaction, the organic layer was separated and the aqueous layer was extracted with chloroform. After the organic layers were combined and washed with water, 20 ml of 28% aqueous ammonia was added dropwise under ice-cooling, followed by stirring of the resulting mixture at room temperature for 1.5 hours. Crystals precipitated by concentrating the reaction mixture under reduced pressure were filtered out and washed with water and subsequently with ether to give 7.6 g of the desired compound. m.p.: 167.degree. to 168.degree. C.

Following the procedure described in Reference Example 7, the desired compound was synthesized using ethyl .alpha.-aminocyanoacetate, ethyl orthoformate and 2-aminothiazole as raw materials. m.p.: 120.degree. to 123.degree. C.

Following the procedure described in Reference Example 8, the desired compound was synthesized using 5-amino-4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole as a raw material. m.p.: 128.degree. to 131.degree. C.

8.0 g of 5-chloro-4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole was dissolved in 30 ml of dimethylformamide. To the resulting solution was added 6.2 g of sodium hydrosulfide (content of 70%), followed by stirring of the resulting mixture at 60.degree. C. for 1 hour. After completion of the reaction, the reaction mixture was poured into ice water and the resulting solution was made weakly acidic with conc. hydrochloric acid. Crystals precipitated were filtered out, washed and dried to give 7.5 g of the desired compound. m.p.: 155.degree. to 158.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 6 by using 4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole-5-thiol as a raw material. m.p.: 84.degree. to 85.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 7 by using ethyl .alpha.-aminocyanoacetate, ethyl orthoformate and 2-amino-4-methylthiazole as raw materials. m.p.: 152.degree. to 155.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 8 by using 5-amino-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole as a raw material. m.p.: 98.degree. to 101.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 12 by using 5-chloro-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole as a raw material. m.p.: 193.degree. to 195.degree. C. 4-ethoxycarbonyl-1-(5-chloro-4-methylthiazol-2-yl)imidazole-5-sulfonamide

A mixture consisting of 4.2 g of 4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole-5-thiol, 3.2 g of anhydrous potassium carbonate, 2.2 g of benzyl chloride, 20 ml of dimethylformamide and 100 ml of acetonitrile was stirred at room temperature for 2 hours. After the reaction, solid materials were separated by filtration, and the filtrate was condensed under reduced pressure to obtain crude 5-benzylthio-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole as oily product. The resulting oily product was dissolved in 100 ml of chloroform and after addition of 13 g of conc. hydrochloric acid and 30 ml of water, 28 g of a 10% sodium hypochlorite solution was added dropwise to the mixture at -10.degree. C. to -5.degree. C. over 15 minutes. After the reaction mixture was stirred at 0.degree. C. or lower for 20 minutes, an organic layer was separated and an aqueous layer was extracted with chloroform. After the organic layers were combined and washed with water, 60 ml of tetrahydrofuran was added to the organic layer and then 20 ml of a 28% aqueous ammonia was added dropwise under icc-cooling, and the mixture was stirred at room temperature for 1.5 hours. After the reaction mixture was concentrated under reduced pressure, ethyl acetate and water were added thereto, an organic layer was separated and an aqueous layer was extracted with ethyl acetate. The organic layers were combined and dried, and then concentrated under reduced pressure to obtain oily product. The resulting oily product was identified as 5-benzylsulfinyl-4-ethoxycarbonyl-1-(5-chloro-4-methylthiazol-2-yl)imidazo le by NMR and MS analyses.

The resulting oily product was again treated with sodium hypochlorite in accordance with the above-mentioned method, and reacted with an aqueous ammonia to obtain 0.86 g of the title compound. m.p.: 136.degree. to 139.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 7 by using ethyl .alpha.-aminocyanoacetate, ethyl orthoformate and 2-amino-1,3,4-thiadiazole as raw materials. m.p.: 181.degree. to 183.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 8 by using 5-amino-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole as a raw material. m.p.: 184.degree. to 185.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 12 by using 5-chloro-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole as a raw material. m.p.: 182.degree. to 185.degree. C. 4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide

The desired compound was synthesized following the precedures described in Reference Example 17 by using 4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-thiol as a raw material and via 5-benzylthio-4-ethoxycarbonyl-b 1-(1,3,4-thiadiazol-2-yl)imidazole (m.p.: 113.degree. to 115.degree. C.) as an indermediate. m.p.: 168.degree. to 171.degree. C.

To 200 ml of acetonitrile, 14.6 g of N-(thiazol-2-yl)methyldithiocarbamate and 12 g of 2,2-diethoxyethylamine were added and the mixture was refluxed under heating for 12 hours. After removing acetonitrile, diisopropyl ether was added to the residue and precipitated crystals were collected by filtration to obtain 9.5 g of N-2,2-diethoxyethyl-N'-(thiazol-2-yl)thiourea (m.p.: 118.degree. to 119.degree. C.). In 55 ml of water was suspended 8.5 g of the resulting crystals, and 25 ml of conc. hydrochloric acid was added thereto and then the mixture was refluxed under heating for 5 hours. The reaction mixture was cooled and then the precipitated crystals were collected by filtration. The resulting crystals were dissolved in 30 ml of a 20% aqueous sodium hydroxide solution and a pH thereof was adjusted to 7 to 6 to precipitate crystals. The precipitated crystals were collected by filtration, washed with water and then dried to obtain 5.0 g of the title compound. m.p.: 211.degree. to 213.degree. C.

The desired compound was synthesized following the procedures described in Reference Example 6 by using 1-(thiazol-2-yl)imidazole-2-thiol as a raw material. m.p.: 157.degree. to 162.degree. C.

(1) Synthesis of 1-(2-pyridyl)imidazole-2-thiol

To a solution of 11.1 g of 2-pyridylisothiocyanate dissolved in 100 ml of ethanol, was added 10.0 g of aminoacetaldehyde diethylacetal, followed by stirring of the resulting mixture under reflux with heating for 40 minutes. After completion of the reaction, the solvent was distilled off under reduced pressure. Crystals precipitated were collected by filtration to give 13.8 g of N-2,2-diethoxyethyl-N'-(2-pyridyl)thiourea (m.p.: 132.degree. to 133.degree. C.). To the thus obtained crystals was added 120 ml of 10% diluted hydrochloric acid, followed by stirring of the resulting mixture under reflux with heating for 30 minutes. The reaction mixture was cooled and adjusted to pH of 5 to 6 with use of 50% aqueous sodium hydroxide to precipitate crystals. The crystals precipitated were filtered out, washed with water and dried to give 8.3 g of the desired compound. m.p.: 162.degree. to 163.degree. C.

(2) Synthesis of 1-(2-pyridyl)imidazole-2-sulfonamide

A mixture consisting of 5.1 g of 1-(2-pyridyl)imidazole-2-thiol, 5.2 g of anhydrous potassium carbonate, 3.7 g of benzyl chloride and 50 ml of acetonitrile was stirred at room temperature for 4 hours. After completion of the reaction, solids were filtered off and the filtrate was concentrated under reduced pressure. Crystals precipitated were collected by filtration to give 7.1 g of 2-benzylthio-1-(2-pyridyl)imidazole (m.p.: 76.degree. to 77.degree. C.). To a mixture consisting of 7.1 g of the thus obtained crystals, 50 ml of methylene chloride, 50 ml of water and 22 g of conc. hydrochloric acid was added dropwise 80 g of 6% sodium hypochlorite solution under vigorous stirring at -10.degree. to 0.degree. C. over 1 hour. After completion of the dropwise addition, the resulting mixture was stirred at the same temperature for 30 minutes. Then, the organic layer was separated and the aqueous layer was extracted with methylene chloride. After the organic layers were combined and washed with water, to the organic layer was added dropwise 10 ml of a 28% aqueous ammonia under ice-cooling while vigorous stirring. After completion of the dropwise addition, the resulting mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated to dryness and the thus obtained concentrated residue was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure to give 3.0 g of a crude product of the desired compound. Crystals precipitated from the resulting crude product were collected by filtration to give 0.8 g of the desired compound. m.p.: 187.degree. to 188.degree. C.

(1) Synthesis of 5-amino-4-ethoxycarbonyl-1-(2-pyridyl)imidazole

In 230 ml of acetonitrile, 8.5 g of ethyl .alpha.-aminocyanoacetate, 10.8 g of ethyl orthoformate and 6.2 g of 2-aminopyridine were heated under reflux for 1.5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and crystals precipitated were filtered off and washed with benzene to give 11.0 g of the desired compound. m.p.: 129.degree. to 131.degree. C.

(2) Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-thiol

11.0 g of 5-amino-4-ethoxycarbonyl-1-(2-pyridyl)imidazole was dissolved in 60 ml of conc. hydrochloric acid and the resulting solution was cooled to -5.degree. C. Subsequently, 3.9 g of sodium nitrite was dissolved in 10 ml of water and the resulting solution was added dropwise to the previously prepared solution while maintaining the temperature at -5.degree. C. or lower. After completion of the dropwise addition, the resulting mixture was stirred at the same temperature for 0.5 hour. The thus obtained solution was added dropwise at around 5.degree. C. to 150 ml of a solution of chloroform containing 1.0 g of cuprous chloride and 12 g of sulfur dioxide. After the resulting mixture was stirred at room temperature for 1 hour, was added thereto 300 ml of water and the organic layer was separated. The aqueous layer was extracted with chloroform and the organic layers were combined, washed with water and dried. The solvent was then removed by distillation to give 11.6 g of 5-chloro-4-ethoxycarbonyl-1-(2-pyridyl)imidazole as an oil.

The thus obtained 11.6 g of 5-chloroimidazole derivative was dissolved in 30 ml of dimethylformamide. To the resulting solution was added 9.2 g of sodium hydrosulfide (content of 70%), followed by stirring of the resulting mixture at room temperature for 1 hour. The reaction mixture was poured into ice water and insolubles were filtered out. Then the filtrate was made weakly acidic with use of conc. hydrochloric acid. Crystals precipitated were collected by filtration, washed with water and dried to give 10.6 g of the desired compound. m.p.: 84.degree. to 87.degree. C.

(3) Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-sulfonamide

To a mixture consisting of 10.6 g of 4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-thiol, 50 ml of water, 100 ml of chloroform and 35.5 g of conc. hydrochloric acid, was added dropwise 128 g of sodium hypochlorite solution (content of 6%) under vigorous stirring at -10.degree. to 0.degree. C. over 1 hour. After completion of the dropwise addition, the resulting mixture was stirred at the same temperature for 0.5 hour. Then, the organic layer was separated and the aqueous layer was extracted with chloroform. After the organic layers were combined and washed with water, to the organic layer was added dropwise 10 ml of 28% aqueous ammonia under ice-cooling, followed by stirring of the resulting mixture at room temperature for 1.5 hours. The reaction mixture was concentrated to dryness under reduced pressure and the residue was extracted with ethyl acetate.

After the solvent was distilled off, crystals precipitated were collected by filtration to give 4.1 g of the desired compound. m.p.: 138.degree. to 139.degree. C.

Specific examples of synthesizing the present compounds using the intermediate obtained in the above Reference Examples will be given below. N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-(4-chloro-1-methylpyrazol -3-yl)imidazole-2-sulfonamide

In 50 ml of acetonitrile, 2.8 g of 1-(4-chloro-1-methylpyrazol-3-yl)imidazole-2-sulfonamide, 1,4 g of ethyl chloroformate and 2.2 g of anhydrous potassium carbonate were heated under reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and ice water was added to the residue and then extracted with chloroform. The aqueous layer was separated and was made acidic with diluted hydrochloric acid. Crystals thus precipitated were filtered, washed with water and dried to give 2.1 g of N-[1-(4-chloro-1-methylpyrazol-3-yl)imidazole-2-sulfonyl]ethyl carbamate. m.p.: 150.degree. to 151.degree. C.

0.7 g of ethyl carbamate thus obtained and 0.32 g of 2-amino-4,6-dimethoxypyrimidine were refluxed under heating in 30 ml of toluene for 2 hours while removing toluene by distillation little by little. After completion of the reaction, the residue was left for cooling and crystals precipitated were filtered out and washed with benzene to give 0.6 g of the desired compound. m.p.: 164.degree. to 165.degree. C. N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-(2-pyridyl)imidazole-2-su lfonamide

In 15 ml of acetonitrile, 0.8 g of 1-(2-pyridyl)imidazole-2-sulfonamide, 0.5 g of methyl chloroformate and 0.75 g of anhydrous potassium carbonate were refluxed under heating for 1 hour. After the reaction, the solvent was removed by distillation under reduced pressure and ice water was added to the residue, followed by extraction with methylene chloride. The aqueous layer was made weakly acidic with use of diluted hydrochloric acid and concentrated under reduced pressure to precipitate crystals. Crystals thus precipitated were filtered, washed with water and dried to give 0.46 g of N-[1-(2-pyridyl)imidazole-2-sulfonyl]methyl carbamate. m.p.: 154.degree. to 156.degree. C.

0.46 g of methyl carbamate thus obtained and 0.25 g of 2-amino-4,6-dimethoxypyrimidine were refluxed under heating in 30 ml of toluene for 1.5 hours while removing toluene little by little by distillation. After the reaction, the filtration was carried out during hot. Crystals precipitated from the filtrate were filtered out to give 0.3 g of the desired compound. m.p.: 146.degree. to 149.degree. C. N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(1,3,4-t hiadiazol-2-yl)imidazole-5-sulfonamide

0.23 g of 1,8-diazobicyclo(5,4,0)-7-undecene was added dropwise to a mixture of 0.45 g of 4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide, 0.41 g of N-(4,6-dimethoxypyrimidine-2-yl)phenylcarbamate and 5 ml of acetonitrile. After stirring the reaction mixture at room temperature for 20 minutes, 20 ml of ice water was added thereto and the mixture was filtered. The filtrate was made acidic with use of conc. hydrochloric acid, and resulting precipitated crystals were collected by filtration, washed with water and ethyl ether, and dried to obtain 0.45 g of the title compound. m.p.: 169.degree. to 171.degree. C.

Chemical structures and physical properties of compounds synthesized according to Examples in addition to the compound synthesized in Examples will be given below. ##STR20##

Examples of compounds to be included in the compound of this invention are shown below in Table 1 to Table 15 in addition to the compounds synthesized in the above Example, which, however, should not be construed to limit this invention.

Be noted that the symbols in Tables have the meanings as shown below.

Me: methyl group, Et: ethyl group, Pr-n: n-propyl group, Pr-i: isopropyl group, Ph: phenyl group

Gn represents the following groups.

Ga=G1 to G35, Gb=G1 to G6, Gc=G1 to G3 ##STR21##

Qn have the following meanings. ##STR22##

J1 to J14 each represent the following groups. ##STR23## ______________________________________ A              B        D           Gn ______________________________________ Q1             H        H           Gb CH.sub.2 - Q1  H        H           Gc CHMe- Q1       H        H           G3 Q2             H        H           Gb Q3             H        H           Gb Q4             H        H           Gb Q5             H        H           Ga CH.sub.2 - Q5  H        H           Gc CHMe - Q5      H        H           G3 Q6             H        H           G3 Q7             H        H           G3 Q8             H        H           G3 Q9             H        H           Gc CH.sub.2 - Q9  H        H           Gc Q10            H        H           Gc Q11            H        H           G3 Q12            H        H           G3 Q13            H        H           G3 Q14            H        H           G1 Q15            H        H           G3 Q16            H        H           Gc Q17            H        H           Gc Q18            H        H           G3 Q19            H        H           Gc Q20            H        H           Gc Q21            H        H           Gc Q22            H        H           G3 Q23            H        H           Gc CH.sub.2 - Q23 H        H           G3 Q24            H        H           Gc Q25            H        H           Gb Q26            H        H           Gb CH.sub.2 - Q26 H        H           G3 CHMe - Q26     H        H           G3 Q27            H        H           G3 Q28            H        H           G3 Q29            H        H           Gc CH.sub.2 - Q29 H        H           G3 Q30            H        H           G3 Q31            H        H           Gc Q32            H        H           Gc CH.sub.2 - Q32 H        H           G3 Q33            H        H           G3 Q34            H        H           G3 Q35            H        H           G3 Q36            H        H           G3 Q37            H        H           Gc Q38            H        H           Gc Q39            H        H           G3 Q40            H        H           Gc Q41            H        H           Gc Q42            H        H           Gc Q43            H        H           G3 Q44            H        H           Gc Q45            H        H           Gc Q46            H        H           Gc Q47            H        H           Gc Q48            H        H           Gc Q49            H        H           G3 Q50            H        H           Gc CH.sub.2 - Q50 H        H           G3 Q51            H        H           Gc Q52            H        H           G3 Q53            H        H           G3 Q54            H        H           Gc Q55            H        H           Gc Q56            H        H           Gc Q57            H        H           G3 Q58            H        H           Gc Q59            H        H           Gc CH.sub.2 - Q59 H        H           G3 Q60            H        H           Gc Q61            H        H           Ga CH.sub.2 - Q61 H        H           Gb CHMe - Q61     H        H           Gc Q62            H        H           Gc Q63            H        H           Gc Q64            H        H           Gb CH.sub.2 - Q64 H        H           G3 CHMe - Q64     H        H           G3 Q65            H        H           G3 Q66            H        H           G3 Q67            H        H           G3 Q68            H        H           G3 Q69            H        H           Gc Q70            H        H           Gc Q71            H        H           Gc Q72            H        H           Gc CH.sub.2 - Q72 H        H           G3 CHMe - Q72     H        H           G3 Q73            H        H           Gc CH.sub.2 - Q73 H        H           G3 Q74            H        H           Gc Q75            H        H           G3 Q76            H        H           G3 Q77            H        H           Gc CH.sub.2 - Q77 H        H           G3 Q78            H        H           Gc Q79            H        H           Gc Q80            H        H           Gc Q81            H        H           G3 Q82            H        H           G3 Q83            H        H           G1 Q84            H        H           G2 Q85            H        H           G3 Q86            H        H           Gc Q87            H        H           G2 Q88            H        H           Gc Q89            H        H           Gc Q90            H        H           Gc Q91            H        H           Gc Q92            H        H           G3 Q93            H        H           Gc Q94            H        H           G3 Q95            H        H           Gc Q96            H        H           G3 Q97            H        H           Gc Q98            H        H           Gc Q99            H        H           Gc Q100           H        H           Gc Q101           H        H           Gc CH.sub.2 - Q101 H        H           G3 Q102           H        H           G3 Q103           H        H           G3 Q104           H        H           G3 Q105           H        H           Gc Q106           H        H           G3 Q107           H        H           Gc Q108           H        H           G1 Q109           H        H           G3 Q110           H        H           G3 Q111           H        H           G3 Q112           H        H           Gc Q113           H        H           Gc Q114           H        H           Gc Q115           H        H           G2 Q116           H        H           Gc Q117           H        H           Gc Q118           H        H           G3 Q119           H        H           Gc Q120           H        H           Gc Q121           H        H           G2 Q122           H        H           Gc Q123           H        H           Gc Q124           H        H           Gc Q125           H        H           Gc Q126           H        H           Gc Q127           H        H           Gc Q128           H        H           Gc Q129           H        H           Gc Q130           H        H           G2 Q131           H        H           Gc Q132           H        H           Gc Q133           H        H           G3 Q134           H        H           G3 Q135           H        H           Gc Q136           H        H           G3 Q137           H        H           G1 Q138           H        H           Gc CH.sub.2 - Q138 H        H           G3 Q139           H        H           G3 Q140           H        H           G1 Q141           H        H           G3 Q142           H        H           Gc Q143           H        H           Gc CH.sub.2 - Q143 H        H           G3 Q144           H        H           G3 Q145           H        H           Gc Q146           H        H           Gc Q147           H        H           G3 Q148           H        H           G1 Q149           H        H           G3 Q150           H        H           G3 Q151           H        H           G2 Q152           H        H           G1 Q153           H        H           Gc Q154           H        H           Gc Q155           H        H           G3 Q156           H        H           G3 Q157           H        H           Gc Q158           H        H           Gc CH.sub.2 - Q158 H        H           G3 CHMe - Q158    H        H           G3 Q159           H        H           G3 Q160           H        H           Gc Q161           H        H           Gc Q162           H        H           Gc Q163           H        H           G3 Q164           H        H           Gc Q165           H        H           Gc Q166           H        H           Gc Q167           H        H           G3 Q168           H        H           G3 Q169           H        H           Gc CH.sub.2 - Q169 H        H           G3 CHMe - Q169    H        H           G3 Q170           H        H           Gc Q171           H        H           Gc Q172           H        H           Gc Q173           H        H           Gc Q174           H        H           Gc Q175           H        H           Gc Q176           H        H           Gc Q177           H        H           Gc CH.sub.2 - Q177 H        H           G3 CHMe - Q177    H        H           G3 Q178           H        H           G3 Q179           H        H           G3 Q180           H        H           Gc CH.sub.2 - Q180 H        H           G3 Q181           H        H           G1 Q182           H        H           G3 Q183           H        H           G3 Q184           H        H           Gc CH.sub.2 - Q184 H        H           G3 CHMe - Q184    H        H           G3 Q185           H        H           G3 Q186           H        H           G3 Q187           H        H           G3 Q188           H        H           Gb Q189           H        H           Gb Q1             H        Me          G3 Q2             H        Me          G3 Q4             H        Me          G3 Q5             H        Me          G3 Q7             H        Me          G3 Q9             H        Me          G3 Q10            H        Me          G3 Q19            H        Me          G3 Q23            H        Me          G3 Q26            H        Me          G3 Q32            H        Me          G3 Q41            H        Me          G3 Q45            H        Me          G3 Q50            H        Me          G3 Q61            H        Me          G3 Q69            H        Me          G3 Q79            H        Me          G3 Q83            H        Me          G3 Q96            H        Me          G3 Q124           H        Me          G3 Q131           H        Me          G3 Q132           H        Me          G3 Q135           H        Me          G3 Q138           H        Me          G3 Q142           H        Me          G3 Q157           H        Me          G3 Q158           H        Me          G3 Q159           H        Me          G3 Q177           H        Me          G3 Q180           H        Me          G3 Q184           H        Me          G3 Q188           H        Me          Gb Q189           H        Me          Gb Q1             Me       H           G3 Q2             Me       H           G3 Q4             Me       H           G3 Q5             Me       H           G3 Q7             Me       H           G3 Q9             Me       H           G3 Q10            Me       H           G3 Q19            Me       H           G3 Q23            Me       H           G3 Q26            Me       H           G3 Q32            Me       H           G3 Q41            Me       H           G3 Q45            Me       H           G3 Q50            Me       H           G3 Q61            Me       H           G3 Q69            Me       H           G3 Q79            Me       H           G3 Q83            Me       H           G3 Q96            Me       H           G3 Q124           Me       H           G3 Q131           Me       H           G3 Q132           Me       H           G3 Q135           Me       H           G3 Q138           Me       H           G3 Q142           Me       H           G3 Q157           Me       H           G3 Q158           Me       H           G3 Q159           Me       H           G3 Q177           Me       H           G3 Q180           Me       H           G3 Q184           Me       H           G3 Q188           Me       H           Gb Q189           Me       H           Gb Q4             Me       Me          G3 Q5             Me       Me          G3 Q7             Me       Me          G3 Q9             Me       Me          G3 Q23            Me       Me          G3 Q26            Me       Me          G3 Q32            Me       Me          G3 Q61            Me       Me          G3 Q96            Me       Me          G3 Q142           Me       Me          G3 Q158           Me       Me          G3 Q188           Me       Me          Gb Q189           Me       Me          Gb Q201           H        H           Ga CH.sub.2 - Q201 H        H           Ga CHMe - Q201    H        H           Gc Q202           H        H           Gb Q203           H        H           Gb Q204           H        H           Gb Q205           H        H           Gb CH.sub.2 - Q205 H        H           Gc Q206           H        H           G3 Q207           H        H           Gc Q208           H        H           G3 Q209           H        H           Gc CH.sub.2 - Q209 H        H           Gc Q210           H        H           Gc Q211           H        H           G3 Q212           H        H           Gc Q213           H        H           Gc Q214           H        H           G1 Q215           H        H           Gc Q216           H        H           Gc Q217           H        H           Gc Q218           H        H           G3 Q219           H        H           Gc Q220           H        H           Gc Q221           H        H           G2 Q222           H        H           Gb CH.sub.2 - Q222 H        H           Gc Q223           H        H           G3 Q224           H        H           Gc Q225           H        H           Gb CH.sub.2 - Q225 H        H           Gc Q226           H        H           G3 Q227           H        H           Gc Q228           H        H           Gc Q229           H        H           Gb CH.sub.2 - Q229 H        H           Gc Q230           H        H           Gc Q231           H        H           Gc CH.sub.2 - Q231 H        H           Gc Q232           H        H           Gc Q233           H        H           G3 Q234           H        H           Gc Q235           H        H           Gc Q236           H        H           G1 Q237           H        H           Gc Q238           H        H           Gc Q239           H        H           G3 Q240           H        H           Gc Q241           H        H           Gc Q242           H        H           Gc Q243           H        H           G3 Q244           H        H           Gc Q245           H        H           Gc Q246           H        H           Gb CH.sub.2 - Q246 H        H           Gc Q247           H        H           Gc Q248           H        H           G2 Q249           H        H           Gc Q250           H        H           Gc CH.sub.2 - Q250 H        H           Gc Q251           H        H           Gc Q252           H        H           G3 Q253           H        H           Gc Q254           H        H           Gc Q255           H        H           Gc Q256           H        H           G2 Q257           H        H           Gc Q258           H        H           Gc Q259           H        H           Gc CH.sub.2 - Q259 H        H           G3 Q260           H        H           Gc CH.sub.2 - Q60 H        H           Gc Q261           H        H           G1 Q262           H        H           Gc Q263           H        H           Gc Q264           H        H           G1 Q201           H        Me          Gc Q202           H        Me          G3 Q205           H        Me          Gc Q209           H        Me          G1 Q222           H        Me          Gc Q225           H        Me          G3 Q229           H        Me          Gc Q231           H        Me          Gc Q246           H        Me          G3 Q260           H        Me          Gc Q201           Me       H           Gc Q202           Me       H           G3 Q205           Me       H           Gc Q209           Me       H           Gc Q222           Me       H           Gc Q225           Me       H           G2 Q229           Me       H           Gc Q231           Me       H           Gc Q246           Me       H           G1 Q260           Me       H           Gc Q201           Me       Me          Gc Q202           Me       Me          G3 Q205           Me       Me          Gc Q209           Me       Me          G3 Q222           Me       Me          Gc Q225           Me       Me          Gc Q229           Me       Me          Gc Q231           Me       Me          G1 Q246           Me       Me          Gc Q260           Me       Me          G3 Q201           C1       H           Gc Q205           C1       H           Gc Q222           C1       H           G3 Q229           C1       H           Gc Q201           H        C1          Gc Q205           H        C1          G1 Q201           C1       Me          Gc Q205           C1       Me          Gc Q201           C1       C1          Gc Q205           C1       C1          Gc Q222           C1       C1          G3 Q229           C1       C1          Gc Q201           Br       H           Gc Q205           Br       H           Gc Q222           Br       H           G2 Q229           Br       H           Gc Q201           H        Br          Gc Q205           H        Br          G3 Q201           Br       Me          Gc Q205           Br       Me          G3 Q201           Br       Br          Gc Q205           Br       Br          G3 Q6             H        Me          Gb Q15            H        Me          Gc Q21            H        Me          G3 Q29            H        Me          Gb Q54            H        Me          Gb Q68            H        Me          Gb Q88            H        Me          G3 Q127           H        Me          G3 Q204           H        Me          G3 Q230           H        Me          G3 Q250           H        Me          G3 Q5             H        C1          G3 Q6             H        C1          G3 Q7             H        C1          G3 Q9             H        C1          G3 Q15            H        C1          G3 Q21            H        C1          G3 Q26            H        C1          G3 Q29            H        C1          G3 Q32            H        C1          G3 Q50            H        C1          G3 Q54            H        C1          G3 Q61            H        C1          G3 Q68            H        C1          G3 Q88            H        C1          G3 Q127           H        C1          G3 Q138           H        C1          G3 Q142           H        C1          G3 Q188           H        C1          G3 Q189           H        C1          G3 Q202           H        C1          G3 Q204           H        C1          G3 Q209           H        C1          G3 Q222           H        C1          G3 Q225           H        C1          G3 Q229           H        C1          G3 Q230           H        C1          G3 Q246           H        C1          G3 Q250           H        C1          G3 Q5             H        NO.sub.2    G3 Q6             H        NHCOMe      G3 Q7             H        NO.sub.2    G3 Q9             H        NO.sub.2    G3 Q15            H        NMe.sub.2   G3 Q21            H        NMe.sub.2   G3 Q26            H        NHCOMe      G3 Q29            H        NO.sub.2    G3 Q32            H        NMe.sub.2   G3 Q50            H        NO.sub.2    G3 Q54            H        NMe.sub.2   G3 Q61            H        NO.sub.2    G3 Q68            H        NO.sub.2    G3 Q88            H        NO.sub.2    G3 Q127           H        NMe.sub.2   G3 Q138           H        NHCOMe      G3 Q142           H        NO.sub.2    G3 Q188           H        NO.sub.2    G3 Q189           H        NO.sub.2    G3 Q201           H        NMe.sub.2   G3 Q202           H        NHCOMe      G3 Q204           H        NO.sub.2    G3 Q205           H        NHCOMe      G3 Q209           H        NMe.sub.2   G3 Q222           H        NO.sub.2    G3 Q225           H        NMe.sub.2   G3 Q229           H        NHCOMe      G3 Q230           H        NO.sub.2    G3 Q246           H        NMe.sub.2   G3 Q250           H        NO.sub.2    G3 ______________________________________ ______________________________________ ##STR24## A            B        D              Gn ______________________________________ Q1           H        COOMe          Gb CH.sub.2 - Q1 H        COOMe          Gc CHMe - Q1    H        COOMe          G3 Q2           H        COOMe          Gb Q3           H        COOMe          Gb Q4           H        COOMe          Gb Q5           H        COOMe          Ga CH.sub.2 - Q5 H        COOMe          Gc CHMe - Q5    H        COOMe          G3 Q6           H        COOMe          G3 Q7           H        COOMe          G3 Q8           H        COOMe          G3 Q9           H        COOMe          Gc CH.sub.2 - Q9 H        COOMe          Gc Q10          H        COOMe          Gc Q11          H        COOMe          G3 Q12          H        COOMe          G3 Q13          H        COOMe          G3 Q14          H        COOMe          G1 Q15          H        COOMe          G3 Q16          H        COOMe          Gc Q17          H        COOMe          Gc Q18          H        COOMe          G3 Q19          H        COOMe          Gc Q20          H        COOMe          Gc Q21          H        COOMe          Gc Q22          H        COOMe          G3 Q23          H        COOMe          Gc CH.sub.2 - Q23 H        COOMe          G3 Q24          H        COOMe          Gc Q25          H        COOMe          Gb Q26          H        COOMe          Ga CH.sub.2 - Q26 H        COOMe          G3 CHMe - Q26   H        COOMe          G3 Q27          H        COOMe          G3 Q28          H        COOMe          G3 Q29          H        COOMe          Gc CH.sub.2 - Q29 H        COOMe          G3 Q30          H        COOMe          G3 Q31          H        COOMe          Gc Q32          H        COOMe          Gc CH.sub.2 - Q32 H        COOMe          G3 Q33          H        COOMe          G3 Q34          H        COOMe          G3 Q35          H        COOMe          G3 Q36          H        COOMe          G3 Q37          H        COOMe          Gc Q38          H        COOMe          Gc Q39          H        COOMe          G3 Q40          H        COOMe          Gc Q41          H        COOMe          Gc Q42          H        COOMe          Gc Q43          H        COOMe          G3 Q44          H        COOMe          Gc Q45          H        COOMe          Gc Q46          H        COOMe          Gc Q47          H        COOMe          Gc Q48          H        COOMe          Gc Q49          H        COOMe          G3 Q50          H        COOMe          Gc CH.sub.2 - Q50 H        COOMe          G3 Q51          H        COOMe          Gc Q52          H        COOMe          G3 Q53          H        COOMe          G3 Q54          H        COOMe          Gc Q55          H        COOMe          Gc Q56          H        COOMe          Gc Q57          H        COOMe          G3 Q58          H        COOMe          Gc Q59          H        COOMe          Gc CH.sub.2 - Q59 H        COOMe          G3 Q60          H        COOMe          Gc Q61          H        COOMe          Ga CH.sub.2 - Q61 H        COOMe          Gb CHMe - Q61   H        COOMe          Gc Q62          H        COOMe          Gc Q63          H        COOMe          Gc Q64          H        COOMe          Gb CH.sub.2 - Q64 H        COOMe          G3 CHMe - Q64   H        COOMe          G3 Q65          H        COOMe          G3 Q66          H        COOMe          G3 Q67          H        COOMe          G3 Q68          H        COOMe          G3 Q69          H        COOMe          Gc Q70          H        COOMe          Gc Q71          H        COOMe          Gc Q72          H        COOMe          Gc CH.sub.2 - Q72 H        COOMe          G3 CHMe - Q72   H        COOMe          G3 Q73          H        COOMe          Gc CH.sub.2 - Q73 H        COOMe          G3 Q74          H        COOMe          Gc Q75          H        COOMe          G3 Q76          H        COOMe          G3 Q77          H        COOMe          Gc CH.sub.2 - Q77 H        COOMe          G3 Q78          H        COOMe          Gc Q79          H        COOMe          Gc Q80          H        COOMe          Gc Q81          H        COOMe          G3 Q82          H        COOMe          G3 Q83          H        COOMe          G1 Q84          H        COOMe          G2 Q85          H        COOMe          G3 Q86          H        COOMe          Gc Q87          H        COOMe          G2 Q88          H        COOMe          Gc Q89          H        COOMe          Gc Q90          H        COOMe          Gc Q91          H        COOMe          Gc Q92          H        COOMe          G3 Q93          H        COOMe          Gc Q94          H        COOMe          G3 Q95          H        COOMe          Gc Q96          H        COOMe          G3 Q97          H        COOMe          Gc Q98          H        COOMe          Gc Q99          H        COOMe          Gc Q100         H        COOMe          Gc Q101         H        COOMe          Gc CH.sub. 2 - Q101 H        COOMe          G3 Q102         H        COOMe          G3 Q103         H        COOMe          G3 Q104         H        COOMe          G3 Q105         H        COOMe          Gc Q106         H        COOMe          G3 Q107         H        COOMe          Gc Q108         H        COOMe          G1 Q109         H        COOMe          G3 Q110         H        COOMe          G3 Q111         H        COOMe          G3 Q112         H        COOMe          Gc Q113         H        COOMe          Gc Q114         H        COOMe          Gc Q115         H        COOMe          G2 Q116         H        COOMe          Gc Q117         H        COOMe          Gc Q118         H        COOMe          G3 Q119         H        COOMe          Gc Q120         H        COOMe          Gc Q121         H        COOMe          G2 Q122         H        COOMe          Gc Q123         H        COOMe          Gc Q124         H        COOMe          Gc Q125         H        COOMe          Gc Q126         H        COOMe          Gc Q127         H        COOMe          Gc Q128         H        COOMe          Gc Q129         H        COOMe          Gc Q130         H        COOMe          G2 Q131         H        COOMe          Gc Q132         H        COOMe          Gc Q133         H        COOMe          G3 Q134         H        COOMe          G3 Q135         H        COOMe          Gc Q136         H        COOMe          G3 Q137         H        COOMe          G1 Q138         H        COOMe          Gc CH.sub.2 - Q138 H        COOMe          G3 Q139         H        COOMe          G3 Q140         H        COOMe          G1 Q141         H        COOMe          G3 Q142         H        COOMe          Gc Q143         H        COOMe          Gc CH.sub.2 - Q143 H        COOMe          G3 Q144         H        COOMe          G3 Q145         H        COOMe          Gc Q146         H        COOMe          Gc Q147         H        COOMe          G3 Q148         H        COOMe          G1 Q149         H        COOMe          G3 Q150         H        COOMe          G3 Q151         H        COOMe          G2 Q152         H        COOMe          G1 Q153         H        COOMe          Gc Q154         H        COOMe          Gc Q155         H        COOMe          G3 Q156         H        COOMe          G3 Q157         H        COOMe          Gc Q158         H        COOMe          Ga CH.sub.2 - Q158 H        COOMe          G3 CHMe - Q158  H        COOMe          G3 Q159         H        COOMe          G3 Q160         H        COOMe          Gc Q161         H        COOMe          Gc Q162         H        COOMe          Gc Q163         H        COOMe          G3 Q164         H        COOMe          Gc Q165         H        COOMe          Gc Q166         H        COOMe          Gc Q167         H        COOMe          G3 Q168         H        COOMe          G3 Q169         H        COOMe          Gc CH.sub.2 - Q169 H        COOMe          G3 CHMe - Q169  H        COOMe          G3 Q170         H        COOMe          Gc Q171         H        COOMe          Gc Q172         H        COOMe          Gc Q173         H        COOMe          Gc Q174         H        COOMe          Gc Q175         H        COOMe          Gc Q176         H        COOMe          Gc Q177         H        COOMe          Gc CH.sub.2 - Q177 H        COOMe          G3 CHMe - Q177  H        COOMe          G3 Q178         H        COOMe          G3 Q179         H        COOMe          G3 Q180         H        COOMe          Gc CH.sub.2 - Q180 H        COOMe          G3 Q181         H        COOMe          G1 Q182         H        COOMe          G3 Q183         H        COOMe          G3 Q184         H        COOMe          Gc CH.sub.2 - Q184 H        COOMe          G3 CHMe - Q184  H        COOMe          G3 Q185         H        COOMe          G3 Q186         H        COOMe          G3 Q187         H        COOMe          G3 Q188         H        COOMe          Gb Q189         H        COOMe          Gb Q1           H        COOEt          Gb CH.sub.2 - Q1 H        COOEt          Gc CHMe - Q1    H        COOEt          G3 Q2           H        COOEt          Gb Q3           H        COOEt          Gb Q4           H        COOEt          Gb Q5           H        COOEt          Ga CH.sub.2 - Q5 H        COOEt          Gc CHMe - Q5    H        COOEt          G3 Q6           H        COOEt          G3 Q7           H        COOEt          G3 Q8           H        COOEt          G3 Q9           H        COOEt          Gc CH.sub.2 - Q9 H        COOEt          Gc Q10          H        COOEt          Gc Q11          H        COOEt          G3 Q12          H        COOEt          G3 Q13          H        COOEt          G3 Q14          H        COOEt          G1 Q15          H        COOEt          G3 Q16          H        COOEt          Gc Q17          H        COOEt          Gc Q18          H        COOEt          G3 Q19          H        COOEt          Gc Q20          H        COOEt          Gc Q21          H        COOEt          Gc Q22          H        COOEt          G3 Q23          H        COOEt          Gc CH.sub.2 - Q23 H        COOEt          G3 Q24          H        COOEt          Gc Q25          H        COOEt          Gb Q26          H        COOEt          Ga CH.sub.2 - Q26 H        COOEt          G3 CHMe - Q26   H        COOEt          G3 Q27          H        COOEt          G3 Q28          H        COOEt          G3 Q29          H        COOEt          Gc CH.sub.2 - Q29 H        COOEt          G3 Q30          H        COOEt          G3 Q31          H        COOEt          Gc Q32          H        COOEt          Gc CH.sub.2 - Q32 H        COOEt          G3 Q33          H        COOEt          G3 Q34          H        COOEt          G3 Q35          H        COOEt          G3 Q36          H        COOEt          G3 Q37          H        COOEt          Gc Q38          H        COOEt          Gc Q39          H        COOEt          G3 Q40          H        COOEt          Gc Q41          H        COOEt          Gc Q42          H        COOEt          Gc Q43          H        COOEt          G3 Q44          H        COOEt          Gc Q45          H        COOEt          Gc Q46          H        COOEt          Gc Q47          H        COOEt          Gc Q48          H        COOEt          Gc Q49          H        COOEt          G3 Q50          H        COOEt          Gc CH.sub.2 - Q50 H        COOEt          G3 Q51          H        COOEt          Gc Q52          H        COOEt          G3 Q53          H        COOEt          G3 Q54          H        COOEt          Gc Q55          H        COOEt          Gc Q56          H        COOEt          Gc Q57          H        COOEt          G3 Q58          H        COOEt          Gc Q59          H        COOEt          Gc CH.sub.2 - Q59 H        COOEt          G3 Q60          H        COOEt          Gc Q61          H        COOEt          Ga CH.sub.2 - Q61 H        COOEt          Gb CHMe - Q61   H        COOEt          Gc Q62          H        COOEt          Gc Q63          H        COOEt          Gc Q64          H        COOEt          Gb CH.sub. 2 - Q64 H        COOEt          G3 CHMe - Q64   H        COOEt          G3 Q65          H        COOEt          G3 Q66          H        COOEt          G3 Q67          H        COOEt          G3 Q68          H        COOEt          G3 Q69          H        COOEt          Gc Q70          H        COOEt          Gc Q71          H        COOEt          Gc Q72          H        COOEt          Gc CH.sub.2 - Q72 H        COOEt          G3 CHMe - Q72   H        COOEt          G3 Q73          H        COOEt          Gc CH.sub.2 - Q73 H        COOEt          G3 Q74          H        COOEt          Gc Q75          H        COOEt          G3 Q76          H        COOEt          G3 Q77          H        COOEt          Gc CH.sub.2 - Q77 H        COOEt          G3 Q78          H        COOEt          Gc Q79          H        COOEt          Gc Q80          H        COOEt          Gc Q81          H        COOEt          G3 Q82          H        COOEt          G3 Q83          H        COOEt          G1 Q84          H        COOEt          G2 Q85          H        COOEt          G3 Q86          H        COOEt          Gc Q87          H        COOEt          G2 Q88          H        COOEt          Gc Q89          H        COOEt          Gc Q90          H        COOEt          Gc Q91          H        COOEt          Gc Q92          H        COOEt          G3 Q93          H        COOEt          Gc Q94          H        COOEt          G3 Q95          H        COOEt          Gc Q96          H        COOEt          G3 Q97          H        COOEt          Gc Q98          H        COOEt          Gc Q99          H        COOEt          Gc Q100         H        COOEt          Gc Q101         H        COOEt          Gc CH.sub.2 - Q101 H        COOEt          G3 Q102         H        COOEt          G3 Q103         H        COOEt          G3 Q104         H        COOEt          G3 Q105         H        COOEt          Gc Q106         H        COOEt          G3 Q107         H        COOEt          Gc Q108         H        COOEt          G1 Q109         H        COOEt          G3 Q110         H        COOEt          G3 Q111         H        COOEt          G3 Q112         H        COOEt          Gc Q113         H        COOEt          Gc Q114         H        COOEt          Gc Q115         H        COOEt          G2 Q116         H        COOEt          Gc Q117         H        COOEt          Gc Q118         H        COOEt          G3 Q119         H        COOEt          Gc Q120         H        COOEt          Gc Q121         H        COOEt          G2 Q122         H        COOEt          Gc Q123         H        COOEt          Gc Q124         H        COOEt          Gc Q125         H        COOEt          Gc Q126         H        COOEt          Gc Q127         H        COOEt          Gc Q128         H        COOEt          Gc Q129         H        COOEt          Gc Q130         H        COOEt          G2 Q131         H        COOEt          Gc Q132         H        COOEt          Gc Q133         H        COOEt          G3 Q134         H        COOEt          G3 Q135         H        COOEt          Gc Q136         H        COOEt          G3 Q137         H        COOEt          G1 Q138         H        COOEt          Gc CH.sub.2 - Q138 H        COOEt          G3 Q139         H        COOEt          G3 Q140         H        COOEt          G1 Q141         H        COOEt          G3 Q142         H        COOEt          Gc Q143         H        COOEt          Gc CH.sub.2 - Q143 H        COOEt          G3 Q144         H        COOEt          G3 Q145         H        COOEt          Gc Q146         H        COOEt          Gc Q147         H        COOEt          G3 Q148         H        COOEt          G1 Q149         H        COOEt          G3 Q150         H        COOEt          G3 Q151         H        COOEt          G2 Q152         H        COOEt          G1 Q153         H        COOEt          Gc Q154         H        COOEt          Gc Q155         H        COOEt          G3 Q156         H        COOEt          G3 Q157         H        COOEt          Gc Q158         H        COOEt          Ga CH.sub.2 - Q158 H        COOEt          G3 CHMe - Q158  H        COOEt          G3 Q159         H        COOEt          G3 Q160         H        COOEt          Gc Q161         H        COOEt          Gc Q162         H        COOEt          Gc Q163         H        COOEt          G3 Q164         H        COOEt          Gc Q165         H        COOEt          Gc Q166         H        COOEt          Gc Q167         H        COOEt          G3 Q168         H        COOEt          G3 Q169         H        COOEt          Gc CH.sub.2 - Q169 H        COOEt          G3 CHMe - Q169  H        COOEt          G3 Q170         H        COOEt          Gc Q171         H        COOEt          Gc Q172         H        COOEt          Gc Q173         H        COOEt          Gc Q174         H        COOEt          Gc Q175         H        COOEt          Gc Q176         H        COOEt          Gc Q177         H        COOEt          Gc CH.sub.2 - Q177 H        COOEt          G3 CHMe - Q177  H        COOEt          G3 Q178         H        COOEt          G3 Q179         H        COOEt          G3 Q180         H        COOEt          Gc CH.sub.2 - Q180 H        COOEt          G3 Q181         H        COOEt          G1 Q182         H        COOEt          G3 Q183         H        COOEt          G3 Q184         H        COOEt          Gc CH.sub.2  - Q184 H        COOEt          G3 CHMe - Q184  H        COOEt          G3 Q185         H        COOEt          G3 Q186         H        COOEt          G3 Q187         H        COOEt          G3 Q188         H        COOEt          Gb Q189         H        COOEt          Gb Q5           H        COOPri         G3 Q26          H        COOPri         G3 Q61          H        COOPri         G3 Q158         H        COOPri         G3 Q5           H        COOCH.sub.2 CH.sub.2 Cl G3 Q26          H        COOCH.sub.2 CH.sub.2 Cl G3 Q61          H        COOCH.sub.2 CH.sub.2 Cl G3 Q158         H        COOCH.sub.2 CH.sub.2 Cl G3 Q5           H        COOCH.sub.2 CHCH.sub.2 G3 Q26          H        COOCH.sub.2 CHCH.sub.2 G3 Q61          H        COOCH.sub.2 CHCH.sub.2 G3 Q158         H        COOCH.sub.2 CHCH.sub.2 G3 Q5           H        COOCH.sub.2 C CH G3 Q26          H        COOCH.sub.2 C CH G3 Q61          H        COOCH.sub.2 C CH G3 Q158         H        COOCH.sub.2 C CH G3 Q1           H        COOPri         G3 Q2           H        COOCH.sub.2 CH.sub.2 Cl G3 Q4           H        COOCH.sub.2 CHCH.sub.2 G3 Q7           H        COOCH.sub.2 C CH G3 Q9           H        COOPri         G3 Q10          H        COOCH.sub.2 CH.sub.2 Cl G3 Q19          H        COOPri         G3 Q23          H        COOCH.sub.2 CHCH.sub.2 G3 Q32          H        COOCH.sub.2 C CH G3 Q41          H        COOPri         G3 Q45          H        COOCH.sub.2 CH.sub.2 Cl G3 Q50          H        COOCH.sub.2 C CH G3 Q69          H        COOPri         G3 Q79          H        COOCH.sub.2 CH.sub.2 Cl G3 Q83          H        COOCH.sub.2 C CH G3 Q96          H        COOPri         G3 Q124         H        COOCH.sub.2 CH.sub.2 Cl G3 Q131         H        COOCH.sub.2 CHCH.sub.2 G3 Q132         H        COOCH.sub.2 C CH G3 Q135         H        COOPri         G3 Q138         H        COOPri         G3 Q142         H        COOCH.sub.2 CHCH.sub.2 G3 Q157         H        COOPri         G3 Q159         H        COOCH.sub.2 CH.sub.2 Cl G3 Q177         H        COOCH.sub.2 CHCH.sub.2 G3 Q180         H        COOCH.sub.2 C CH G3 Q184         H        COOPri         G3 Q5           H        COOH           G3 Q26          H        COOH           G3 Q61          H        COOH           G3 Q158         H        COOH           G3 Q5           H        CONHMe         G3 Q26          H        CONHMe         G3 Q61          H        CONHMe         G3 Q158         H        CONHMe         G3 Q5           H        CONMe.sub.2    G3 Q26          H        CONMe.sub.2    G3 Q61          H        CONMe.sub.2    G3 Q158         H        CONMe.sub.2    G3 Q5           H        COMe           G3 Q26          H        COMe           G3 Q61          H        COMe           G3 Q158         H        COMe           G3 Q189         H        COMe           Gb Q5           H        COEt           G3 Q26          H        COEt           G3 Q61          H        COEt           G3 Q158         H        COEt           G3 Q189         H        COEt           Gb Q5           H        COPri          G3 Q26          H        COPri          G3 Q61          H        COPri          G3 Q158         H        COPri          G3 Q5           H        COPh           G3 Q26          H        COPh           G3 Q61          H        COPh           G3 Q158         H        COPh           G3 Q1           H        COMe           G3 Q2           H        COEt           G3 Q4           H        COMe           G3 Q7           H        COMe           G3 Q9           H        COEt           G3 Q10          H        COPri          G3 Q19          H        COPh           G3 Q23          H        COMe           G3 Q32          H        COMe           G3 Q41          H        COPri          G3 Q45          H        COPh           G3 Q50          H        COMe           G3 Q69          H        COEt           G3 Q79          H        COPri          G3 Q83          H        COPh           G3 Q96          H        COMe           G3 Q124         H        COEt           G3 Q131         H        COMe           G3 Q132         H        COMe           G3 Q135         H        COEt           G3 Q138         H        COPri          G3 Q142         H        COPh           G3 Q157         H        COMe           G3 Q159         H        COEt           G3 Q177         H        COMe           G3 Q180         H        COMe           G3 Q184         H        COPri          G3 Q4           H        CN             G3 Q5           H        CN             G3 Q7           H        CN             G3 Q9           H        CN             G3 Q23          H        CN             G3 Q26          H        CN             G3 Q32          H        CN             G3 Q61          H        CN             G3 Q96          H        CN             G3 Q142         H        CN             G3 Q158         H        CN             G3 Q5           H        H              G3 Q26          H        H              G3 Q61          H        H              G3 Q158         H        H              G3 Q5           H        Me             G3 Q26          H        Me             G3 Q61          H        Me             G3 Q158         H        Me             G3 Q5           H        Et             G3 Q26          H        Et             G3 Q61          H        Et             G3 Q158         H        Et             G3 Q5           H        Pri            G3 Q26          H        Pri            G3 Q61          H        Pri            G3 Q158         H        Pri            G3 Q5           H        CHCH.sub.2     G3 Q26          H        CHCH.sub.2     G3 Q61          H        CHCHMe         G3 Q158         H        CHCHMe         G3 Q5           H        CH.sub.2 CHCH.sub.2 G3 Q26          H        CH.sub.2 CHCH.sub.2 G3 Q61          H        CH.sub.2 CHCH.sub. 2 G3 Q158         H        CH.sub.2 CHCH.sub.2 G3 Q1           H        H              G3 Q2           H        Me             G3 Q4           H        Me             G3 Q7           H        Me             G3 Q9           H        Et             G3 Q10          H        Pri            G3 Q19          H        Me             G3 Q23          H        CH.sub.2 CHCH.sub.2 G3 Q32          H        H              G3 Q41          H        Me             G3 Q45          H        Me             G3 Q50          H        Et             G3 Q69          H        Pri            G3 Q79          H        Me             G3 Q83          H        Et             G3 Q96          H        Me             G3 Q124         H        Et             G3 Q131         H        Me             G3 Q132         H        CH.sub.2 CHCH.sub.2 G3 Q135         H        Et             G3 Q138         H        Pri            G3 Q142         H        H              G3 Q157         H        Me             G3 Q159         H        Me             G3 Q177         H        H              G3 Q180         H        Me             G3 Q184         H        Me             G3 Q5           H        CH.sub.2 Cl    G3 Q26          H        CH.sub.2 Cl    G3 Q61          H        CH.sub.2 Cl    G3 Q158         H        CH.sub.2 Cl    G3 Q5           H        CH.sub.2 CH.sub.2 Cl G3 Q26          H        CH.sub.2 CH.sub.2 Cl G3 Q61          H        CH.sub.2 CH.sub.2 Cl G3 Q158         H        CH.sub.2 CH.sub.2 Cl G3 Q5           H        CF.sub.3       G3 Q26          H        CF.sub.3       G3 Q61          H        CF.sub.3       G3 Q158         H        CF.sub.3       G3 Q5           H        CFCFCl         G3 Q26          H        CFCFCl         G3 Q61          H        CH.sub.2 Ph    G3 Q158         H        CH.sub.2 Ph    G3 Q5           H        Ph             G3 Q26          H        Ph             G3 Q61          H        Ph             G3 Q158         H        Ph             G3 Q5           H        Ph2-Cl         G3 Q26          H        Ph2-Me         G3 Q61          H        Ph2-Cl         G3 Q158         H        Ph2-Me         G3 Q1           H        Ph             G3 Q2           H        CH.sub.2 Cl    G3 Q4           H        CH.sub.2 CH.sub.2 Cl G3 Q7           H        Ph             G3 Q9           H        CF.sub.3       G3 Q10          H        CF.sub.3       G3 Q19          H        CFCFCl         G3 Q23          H        CH.sub.2 CH.sub.2 Cl G3 Q32          H        Ph             G3 Q41          H        Ph2-Cl         G3 Q45          H        Ph2-Me         G3 Q50          H        CH.sub.2 CH.sub.2 Cl G3 Q69          H        Ph             G3 Q79          H        CF.sub.3       G3 Q83          H        CF.sub.3       G3 Q96          H        Ph             G3 Q124         H        Ph2-Cl         G3 Q131         H        Ph2-Me         G3 Q132         H        CH.sub.2 CH.sub.2 Cl G3 Q135         H        Ph             G3 Q138         H        CF.sub.3       G3 Q142         H        CF.sub.3       G3 Q157         H        CFCFCl         G3 Q159         H        CH.sub.2 Cl    G3 Q177         H        CH.sub.2 CH.sub.2 Cl G3 Q180         H        Ph             G3 Q184         H        Ph2-Cl         G3 Q5           H        Cl             G3 Q26          H        Cl             G3 Q61          H        Cl             G3 Q158         H        Cl             G3 Q5           H        Br             G3 Q26          H        Br             G3 Q61          H        Br             G3 Q158         H        Br             G3 Q5           H        F              G3 Q26          H        F              G3 Q61          H        I              G3 Q158         H        I              G3 Q1           H        Cl             G3 Q2           H        Cl             G3 Q4           H        Cl             G3 Q7           H        Br             G3 Q9           H        F              G3 Q10          H        I              G3 Q19          H        Cl             G3 Q23          H        Cl             G3 Q32          H        Cl             G3 Q41          H        Br             G3 Q45          H        Br             G3 Q50          H        F              G3 Q69          H        Cl             G3 Q79          H        F              G3 Q83          H        Cl             G3 Q96          H        Cl             G3 Q124         H        Cl             G3 Q131         H        Br             G3 Q132         H        Br             G3 Q135         H        F              G3 Q138         H        Br             G3 Q142         H        Cl             G3 Q157         H        Cl             G3 Q159         H        Cl             G3 Q177         H        Br             G3 Q180         H        Br             G3 Q184         H        Cl             G3 Q4           H        NO.sub.2       G3 Q5           H        NO.sub.2       G3 Q7           H        NO.sub.2       G3 Q9           H        NO.sub.2       G3 Q23          H        NO.sub.2       G3 Q26          H        NO.sub.2       G3 Q32          H        NO.sub.2       G3 Q61          H        NO.sub.2       G3 Q96          H        NO.sub.2       G3 Q142         H        NO.sub.2       G3 Q158         H        NO.sub.2       G3 Q5           H        NH.sub.2       G3 Q26          H        NH.sub.2       G3 Q61          H        NH.sub.2       G3 Q158         H        NH.sub.2       G3 Q5           H        NHMe           G3 Q26          H        NHMe           G3 Q61          H        NHMe           G3 Q158         H        NHMe           G3 Q5           H        NMe.sub.2      G3 Q26          H        NMe.sub.2      G3 Q61          H        NMe.sub.2      G3 Q158         H        NMe.sub.2      G3 Q5           H        NMeEt          G3 Q26          H        NMeEt          G3 Q61          H        NMeEt          G3 Q158         H        NMeEt          G3 Q5           H        NHSO.sub.2 Me  G3 Q26          H        NHSO.sub.2 Me  G3 Q61          H        NHSO.sub.2 Me  G3 Q158         H        NHSO.sub.2 Me  G3 Q1           H        NH.sub.2       G3 Q2           H        NH.sub.2       G3 Q4           H        NH.sub.2       G3 Q7           H        NHMe           G3 Q9           H        NHMe           G3 Q10          H        NMe.sub.2      G3 Q19          H        NMeEt          G3 Q23          H        NMe.sub.2      G3 Q32          H        NMeEt          G3 Q41          H        NH.sub.2       G3 Q45          H        NH.sub.2       G3 Q50          H        NHMe           G3 Q69          H        NHMe           G3 Q79          H        NMe.sub.2      G3 Q83          H        NMeEt          G3 Q96          H        NHSO.sub.2 Me  G3 Q124         H        NMe.sub.2      G3 Q131         H        NMeEt          G3 Q132         H        NH.sub.2       G3 Q135         H        NH.sub.2       G3 Q138         H        NHMe           G3 Q142         H        NHMe           G3 Q157         H        NHSO.sub.2 Me  G3 Q159         H        NMe.sub.2      G3 Q177         H        NMeEt          G3 Q180         H        NH.sub.2       G3 Q184         H        NH.sub.2       G3 Q4           H        NHCOMe         G3 Q5           H        NHCOMe         G3 Q7           H        NHCOMe         G3 Q9           H        NHCOMe         G3 Q23          H        NHCOMe         G3 Q26          H        NHCOMe         G3 Q32          H        NHCOMe         G3 Q61          H        NHCOMe         G3 Q96          H        NHCOMe         G3 Q142         H        NHCOMe         G3 Q158         H        NHCOMe         G3 Q5           H        NHCOEt         G3 Q26          H        NHCOEt         G3 Q61          H        NHCOEt         G3 Q158         H        NHCOEt         G3 Q5           H        OMe            G3 Q26          H        OMe            G3 Q61          H        OMe            G3 Q158         H        OMe            G3 Q5           H        OEt            G3 Q26          H        OEt            G3 Q61          H        OEt            G3 Q158         H        OEt            G3 Q5           H        CH.sub.2 OMe   G3 Q26          H        CH.sub.2 OMe   G3 Q61          H        CH.sub.2 OMe   G3 Q158         H        CH.sub.2 OMe   G3 Q5           H        SMe            G3 Q26          H        SMe            G3 Q61          H        SMe            G3 Q158         H        SMe            G3 Q5           H        SO.sub.2 OMe   G3 Q26          H        SO.sub.2 OMe   G3 Q61          H        SO.sub.2 OMe   G3 Q158         H        SO.sub.2 OMe   G3 Q1           H        OMe            G3 Q2           H        OMe            G3 Q4           H        OEt            G3 Q7           H        SO.sub.2 OMe   G3 Q9           H        CH.sub.2 OMe   G3 Q10          H        SMe            G3 Q19          H        SO.sub.2 OMe   G3 Q23          H        OMe            G3 Q32          H        OEt            G3 Q41          H        SO.sub.2 OMe   G3 Q45          H        CH.sub.2 OMe   G3 Q50          H        SMe            G3 Q69          H        SO.sub.2 OMe   G3 Q79          H        OMe            G3 Q83          H        OEt            G3 Q96          H        CH.sub.2 OMe   G3 Q124         H        SMe            G3 Q131         H        OMe            G3 Q132         H        OEt            G3 Q135         H        CH.sub.2 OMe   G3 Q138         H        SMe            G3 Q142         H        SO.sub.2 OMe   G3 Q157         H        OMe            G3 Q159         H        OEt            G3 Q177         H        SO.sub.2 OMe   G3 Q180         H        OMe            G3 Q184         H        OEt            G3 Q4           H        SO.sub.2 Me    G3 Q5           H        SO.sub.2 Me    G3 Q7           H        SO.sub.2 Me    G3 Q9           H        SO.sub.2 Me    G3 Q23          H        SO.sub.2 Me    G3 Q26          H        SO.sub.2 Me    G3 Q32          H        SO.sub.2 Me    G3 Q61          H        SO.sub.2 Me    G3 Q96          H        SO.sub.2 Me    G3 Q142         H        SO.sub.2 Me    G3 Q158         H        SO.sub.2 Me    G3 Q188         H        SO.sub.2 Me    Gb Q189         H        SO.sub. 2 Me   Gb Q5           H        SO.sub.2 Ph    G3 Q26          H        SO.sub.2 Ph    G3 Q61          H        SO.sub.2 Ph    G3 Q158         H        SO.sub.2 Ph    G3 Q5           H        SO.sub.2 NH.sub.2 G3 Q26          H        SO.sub.2 NH.sub.2 G3 Q61          H        SO.sub.2 NH.sub.2 G3 Q158         H        SO.sub.2 NH.sub.2 G3 Q5           H        SO.sub.2 NHMe  G3 Q26          H        SO.sub.2 NHMe  G3 Q61          H        SO.sub.2 NHMe  G3 Q158         H        SO.sub.2 NHMe  G3 Q5           H        SO.sub.2 NMe.sub.2 G3 Q26          H        SO.sub.2 NMe.sub.2 G3 Q61          H        SO.sub.2 NMe.sub.2 G3 Q158         H        SO.sub.2 NMe.sub.2 G3 Q1           H        SO.sub.2 Me    G3 Q2           H        SO.sub.2 Me    G3 Q4           H        SO.sub.2 Ph    G3 Q7           H        SO.sub.2 NH.sub.2 G3 Q9           H        SO.sub.2 NH.sub.2 G3 Q10          H        SO.sub.2 Ph    G3 Q19          H        SO.sub.2 Me    G3 Q23          H        SO.sub.2 Ph    G3 Q32          H        SO.sub.2 NHMe  G3 Q41          H        SO.sub.2 NMe.sub.2 G3 Q45          H        SO.sub.2 Me    G3 Q50          H        SO.sub.2 NH.sub.2 G3 Q69          H        SO.sub.2 Me    G3 Q79          H        SO.sub.2 Ph    G3 Q83          H        SO.sub.2 Me    G3 Q96          H        SO.sub.2 NMe.sub.2 G3 Q124         H        SO.sub.2 NH.sub.2 G3 Q131         H        SO.sub.2 Me    G3 Q132         H        SO.sub.2 Me    G3 Q135         H        SO.sub.2 NHMe  G3 Q138         H        SO.sub.2 NMe.sub.2 G3 Q142         H        SO.sub.2 NH.sub.2 G3 Q157         H        SO.sub.2 Me    G3 Q159         H        SO.sub.2 Me    G3 Q177         H        SO.sub.2 NHMe  G3 Q180         H        SO.sub.2 NHMe.sub.2 G3 Q184         H        SO.sub.2 Me    G3 Q1           Me       COOMe          G3 Q2           Me       COOMe          G3 Q4           Me       COOMe          G3 Q5           Me       COOMe          G3 Q7           Me       COOMe          G3 Q9           Me       COOMe          G3 Q10          Me       COOMe          G3 Q19          Me       COOMe          G3 Q23          Me       COOMe          G3 Q26          Me       COOMe          G3 Q32          Me       COOMe          G3 Q41          Me       COOMe          G3 Q45          Me       COOMe          G3 Q50          Me       COOMe          G3 Q61          Me       COOMe          G3 Q69          Me       COOMe          G3 Q79          Me       COOMe          G3 Q83          Me       COOMe          G3 Q96          Me       COOMe          G3 Q124         Me       COOMe          G3 Q131         Me       COOMe          G3 Q132         Me       COOMe          G3 Q135         Me       COOMe          G3 Q138         Me       COOMe          G3 Q142         Me       COOMe          G3 Q157         Me       COOMe          G3 Q158         Me       COOMe          G3 Q159         Me       COOMe          G3 Q177         Me       COOMe          G3 Q180         Me       COOMe          G3 Q184         Me       COOMe          G3 Q1           Me       COOEt          G3 Q2           Me       COOEt          G3 Q4           Me       COOEt          G3 Q5           Me       COOEt          G3 Q7           Me       COOEt          G3 Q9           Me       COOEt          G3 Q10          Me       COOEt          G3 Q19          Me       COOEt          G3 Q23          Me       COOEt          G3 Q26          Me       COOEt          G3 Q32          Me       COOEt          G3 Q41          Me       COOEt          G3 Q45          Me       COOEt          G3 Q50          Me       COOEt          G3 Q61          H        COOEt          G3 Q69          Me       COOEt          G3 Q79          Me       COOEt          G3 Q83          Me       COOEt          G3 Q96          Me       COOEt          G3 Q124         Me       COOEt          G3 Q131         Me       COOEt          G3 Q132         Me       COOEt          G3 Q135         Me       COOEt          G3 Q138         Me       COOEt          G3 Q142         Me       COOEt          G3 Q157         Me       COOEt          G3 Q158         Me       COOEt          G3 Q159         Me       COOEt          G3 Q177         Me       COOEt          G3 Q180         Me       COOEt          G3 Q184         Me       COOEt          G3 Q158         Me       COOEt          G3 Q5           Me       COOPri         G3 Q26          Me       COOPri         G3 Q61          Me       COOPri         G3 Q158         Me       COOPri         G3 Q5           Me       COOCH.sub.2 CH.sub.2 Cl G3 Q26          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q61          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q158         Me       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Me       COOCH.sub.2 CHCH.sub.2 G3 Q26          Me       COOCH.sub.2 CHCH.sub.2 G3 Q61          Me       COOCH.sub.2 CHCH.sub.2 G3 Q158         Me       COOCH.sub.2 CHCH.sub.2 G3 Q5           Me       COOCH.sub.2 C CH G3 Q26          Me       COOCH.sub.2 C CH G3 Q61          Me       COOCH.sub.2 C CH G3 Q158         Me       COOCH.sub.2 C CH G3 Q5           Me       CONHMe         G3 Q26          Me       CONHMe         G3 Q61          Me       CONHMe         G3 Q158         Me       CONHMe         G3 Q5           Me       CONMe.sub.2    G3 Q26          Me       CONMe.sub.2    G3 Q61          Me       CONMe.sub.2    G3 Q158         Me       CONMe.sub.2    G3 Q1           Me       COOPri         G3 Q2           Me       COOPri         G3 Q4           Me       COOCH.sub.2 CH.sub.2 Cl G3 Q7           Me       COOCH.sub.2 CHCH.sub.2 G3 Q9           Me       COOCH.sub.2 C CH G3 Q10          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q19          Me       COOPri         G3 Q23          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q32          Me       CONMe.sub.2    G3 Q41          Me       COOPri         G3 Q45          Me       CONHMe         G3 Q50          Me       CONMe.sub.2    G3 Q69          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q79          Me       COOCH.sub.2 CHCH.sub.2 G3 Q83          Me       COOPri         G3 Q96          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q124         Me       COOPri         G3 Q131         Me       COOCH.sub.2 CH.sub.2 Cl G3 Q132         Me       CONHMe         G3 Q135         Me       CONMe.sub.2    G3 Q138         Me       COOCH.sub.2 C CH G3 Q142         Me       COOPri         G3 Q157         Me       COOPri         G3 Q159         Me       COOCH.sub.2 CHCH.sub.2 G3 Q177         Me       COOCH.sub.2 C CH G3 Q180         Me       COOPri         G3 Q184         Me       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Me       COMe           G3 Q26          Me       COMe           G3 Q61          Me       COMe           G3 Q158         Me       COMe           G3 Q5           Me       COEt           G3 Q26          Me       COEt           G3 Q61          Me       COEt           G3 Q158         Me       COEt           G3 Q5           Me       COPri          G3 Q26          Me       COPri          G3 Q61          Me       COPri          G3 Q158         Me       COPri          G3 Q5           Me       CN             G3 Q26          Me       CN             G3 Q61          Me       CN             G3 Q158         Me       CN             G3 Q5           Me       H              G3 Q26          Me       H              G3 Q61          Me       H              G3 Q158         Me       H              G3 Q5           Me       Me             G3 Q26          Me       Me             G3 Q61          Me       Me             G3 Q158         Me       Me             G3 Q5           Me       Et             G3 Q26          Me       Et             G3 Q61          Me       Et             G3 Q158         Me       Et             G3 Q5           Me       Pri            G3 Q26          Me       Pri            G3 Q61          Me       CHCH.sub.2     G3 Q158         Me       CHCH.sub.2     G3 Q5           Me       CHCHMe         G3 Q26          Me       CH.sub.2 CHCH.sub.2 G3 Q61          Me       CHCHMe         G3 Q158         Me       CH.sub.2 CHCH.sub.2 G3 Q1           Me       COMe           G3 Q2           Me       COEt           G3 Q4           Me       CHCHMe         G3 Q7           Me       CH.sub.2 CHCH.sub.2 G3 Q9           Me       CN             G3 Q10          Me       H              G3 Q19          Me       Me             G3 Q23          Me       COMe           G3 Q32          Me       COEt           G3 Q41          Me       H              G3 Q45          Me       Me             G3 Q50          Me       COPri          G3 Q69          Me       CN             G3 Q79          Me       Et             G3 Q83          Me       Pri            G3 Q96          Me       COMe           G3 Q124         Me       COEt           G3 Q131         Me       CH.sub.2 CHCH.sub.2 G3 Q132         Me       Me             G3 Q135         Me       COPr-i         G3 Q138         Me       CN             G3 Q142         Me       Et             G3 Q157         Me       CH.sub.2 CHCH.sub.2 G3 Q159         Me       COMe           G3 Q177         Me       COEt           G3 Q180         Me       CHCHMe         G3 Q184         Me       COMe           G3 Q5           Me       CH.sub.2 Cl    G3 Q26          Me       CH.sub. 2 Cl   G3 Q5           Me       CH.sub.2 CH.sub.2 Cl G3 Q26          Me       CH.sub.2 CH.sub.2 Cl G3 Q61          Me       CH.sub.2 CH.sub.2 Cl G3 Q158         Me       CH.sub.2 CH.sub.2 Cl G3 Q5           Me       CF.sub.3       G3 Q26          Me       CF.sub.3       G3 Q61          Me       CF.sub.3       G3 Q158         Me       CF.sub.3       G3 Q5           Me       CFCFCl         G3 Q26          Me       CFCFCl         G3 Q61          Me       CH.sub.2 Ph    G3 Q158         Me       CH.sub.2 Ph    G3 Q5           Me       Ph             G3 Q26          Me       Ph             G3 Q61          Me       Ph             G3 Q158         Me       Ph             G3 Q5           Me       Ph2-Cl         G3 Q26          Me       Ph2-Cl         G3 Q61          Me       Ph2-Me         G3 Q158         Me       Ph2-Me         G3 Q5           Me       Cl             G3 Q26          Me       Cl             G3 Q61          Me       Cl             G3 Q158         Me       Cl             G3 Q5           Me       Br             G3 Q26          Me       Br             G3 Q61          Me       Br             G3 Q158         Me       Br             G3 Q5           Me       F              G3 Q26          Me       F              G3 Q61          Me       I              G3 Q158         Me       I              G3 Q1           Me       Ph             G3 Q2           Me       Cl             G3 Q4           Me       CH.sub.2 CH.sub.2 Cl G3 Q7           Me       Ph             G3 Q9           Me       Ph             G3 Q10          Me       Cl             G3 Q19          Me       Cl             G3 Q23          Me       Br             G3 Q32          Me       CH.sub. 2 Cl   G3 Q41          Me       CH.sub.2 CH.sub.2 Cl G3 Q45          Me       CF.sub.3       G3 Q50          Me       Cl             G3 Q69          Me       Cl             G3 Q79          Me       Br             G3 Q83          Me       Ph             G3 Q96          Me       CF.sub.3       G3 Q124         Me       CF.sub.3       G3 Q131         Me       CH.sub.2 CH.sub.2 Cl G3 Q132         Me       Ph             G3 Q135         Me       Br             G3 Q138         Me       Ph             G3 Q142         Me       Ph             G3 Q157         Me       Cl             G3 Q159         Me       Br             G3 Q177         Me       CF.sub.3       G3 Q180         Me       CH.sub.2 CH.sub.2 Cl G3 Q184         Me       Ph             G3 Q5           Me       NO.sub.2       G3 Q26          Me       NO.sub.2       G3 Q61          Me       NO.sub.2       G3 Q158         Me       NO.sub.2       G3 Q5           Me       NH.sub.2       G3 Q26          Me       NH.sub.2       G3 Q61          Me       NH.sub.2       G3 Q158         Me       NH.sub.2       G3 Q5           Me       NHMe           G3 Q26          Me       NHMe           G3 Q61          Me       NHMe           G3 Q158         Me       NHMe           G3 Q5           Me       NMe.sub.2      G3 Q26          Me       NMe.sub.2      G3 Q61          Me       NMe.sub.2      G3 Q158         Me       NMe.sub.2      G3 Q5           Me       NMeEt          G3 Q26          Me       NMeEt          G3 Q5           Me       NHCOMe         G3 Q26          Me       NHCOMe         G3 Q61          Me       NHCOMe         G3 Q158         Me       NHCOMe         G3 Q5           Me       NHCOEt         G3 Q26          Me       NHCOEt         G3 Q61          Me       NHSO.sub.2 Me  G3 Q158         Me       NHSO.sub.2 Me  G3 Q5           Me       OMe            G3 Q26          Me       OMe            G3 Q61          Me       OMe            G3 Q158         Me       OMe            G3 Q5           Me       OEt            G3 Q26          Me       OEt            G3 Q61          Me       CH.sub.2 OMe   G3 Q158         Me       CH.sub.2 OMe   G3 Q1           Me       NO.sub.2       G3 Q2           Me       NHCOMe         G3 Q4           Me       NHCOEt         G3 Q7           Me       NHMe           G3 Q9           Me       NO.sub.2       G3 Q10          Me       NH.sub.2       G3 Q19          Me       NHCOMe         G3 Q23          Me       OMe            G3 Q32          Me       NHCOMe         G3 Q41          Me       NHCOEt         G3 Q45          Me       CH.sub.2 OMe   G3 Q50          Me       OMe            G3 Q69          Me       OEt            G3 Q79          Me       NO.sub.2       G3 Q83          Me       NH.sub.2       G3 Q96          Me       NMe.sub.2      G3 Q124         Me       NMeEt          G3 Q131         Me       NHCOMe         G3 Q132         Me       NHCOEt         G3 Q135         Me       NO.sub.2       G3 Q138         Me       OMe            G3 Q142         Me       OEt            G3 Q157         Me       NO.sub.2       G3 Q159         Me       NH.sub.2       G3 Q177         Me       OMe            G3 Q180         Me       NHCOMe         G3 Q184         Me       NO.sub.2       G3 Q26          Me       SMe            G3 Q61          Me       SMe            G3 Q5           Me       SO.sub.2 Me    G3 Q26          Me       SO.sub.2 Me    G3 Q61          Me       SO.sub.2 Me    G3 Q158         Me       SO.sub.2 Me    G3 Q5           Me       SO.sub.2 Ph    G3 Q26          Me       SO.sub.2 Ph    G3 Q61          Me       SO.sub.2 Ph    G3 Q158         Me       SO.sub.2 Ph    G3 Q5           Me       SO.sub.2 OMe   G3 Q26          Me       SO.sub.2 OMe   G3 Q61          Me       SO.sub.2 NH.sub.2 G3 Q158         Me       SO.sub.2 NH.sub.2 G3 Q5           Me       SO.sub.2 NHMe  G3 Q26          Me       SO.sub.2 NHMe  G3 Q61          Me       SO.sub.2 NHMe  G3 Q158         Me       SO.sub.2 NHMe  G3 Q5           Me       SO.sub.2 NMe.sub.2 G3 Q26          Me       SO.sub.2 NMe.sub.2 G3 Q61          Me       SO.sub.2 NMe.sub.2 G3 Q158         Me       SO.sub.2 NMe.sub.2 G3 Q1           Me       SO.sub.2 Ph    G3 Q2           Me       SO.sub.2 OMe   G3 Q4           Me       SO.sub.2 NHMe  G3 Q7           Me       SO.sub.2 NMe.sub.2 G3 Q9           Me       SO.sub.2 Me    G3 Q10          Me       SO.sub.2 Me    G3 Q19          Me       SMe            G3 Q23          Me       SO.sub.2 Me    G3 Q32          Me       SO.sub.2 OMe   G3 Q41          Me       SO.sub.2 NMe.sub.2 G3 Q45          Me       SO.sub.2 NHMe  G3 Q50          Me       SO.sub.2 NMe.sub.2 G3 Q69          Me       SO.sub.2 Me    G3 Q79          Me       SO.sub.2 Me    G3 Q83          Me       SO.sub.2 Ph    G3 Q96          Me       SO.sub.2 OMe   G3 Q124         Me       SO.sub.2 NMe.sub.2 G3 Q131         Me       SO.sub.2 NHMe  G3 Q132         Me       SO.sub.2 NMe.sub.2 G3 Q135         Me       SO.sub.2 Ph    G3 Q138         Me       SO.sub.2 Ph    G3 Q142         Me       SO.sub.2 Me    G3 Q157         Me       SO.sub.2 Me    G3 Q159         Me       SO.sub.2 NHMe  G3 Q177         Me       SO.sub.2 NMe.sub.2 G3 Q180         Me       SO.sub.2 NMe.sub.2 G3 Q184         Me       SO.sub.2 Me.sub.2 G3 Q5           Et       COOMe          G3 Q26          Et       COOMe          G3 Q61          Et       COOMe          G3 Q142         Et       COOMe          G3 Q158         Et       COOMe          G3 Q159         Et       COOMe          G3 Q4           Et       COOEt          G3 Q5           Et       COOEt          G3 Q9           Et       COOEt          G3 Q26          Et       COOEt          G3 Q32          Et       COOEt          G3 Q61          Et       COOEt          G3 Q69          Et       COOEt          G3 Q96          Et       COOEt          G3 Q158         Et       COOEt          G3 Q61          Et       COOPri         G3 Q158         Et       COOPri         G3 Q5           Et       COOCH.sub.2 CH.sub.2 Cl G3 Q26          Et       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Et       COOCH.sub.2 CHCH.sub.2 G3 Q158         Et       COOCH.sub.2 CHCH.sub.2 G3 Q5           Et       COOCH.sub.2 C CH G3 Q26          Et       COOCH.sub.2 C CH G3 Q5           Et       CONHMe         G3 Q26          Et       CONMe.sub.2    G3 Q1           Et       COOPri         G3 Q4           Et       COOCH.sub.2 CH.sub.2 Cl G3 Q69          Et       COOCH.sub.2 CH.sub.2 Cl G3 Q79          Et       COOCH.sub.2 CHCH.sub.2 G3 Q83          Et       COOPri         G3 Q96          Et       COOCH.sub.2 CH.sub.2 Cl G3 Q131         Et       COOCH.sub.2 CH.sub.2 Cl G3 Q157         Et       COOPri         G3 Q159         Et       COOCH.sub.2 CHCH.sub.2 G3 Q184         Et       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Et       COMe           G3 Q26          Et       COMe           G3 Q158         Et       COEt           G3 Q5           Et       COPri          G3 Q26          Et       CN             G3 Q61          Et       H              G3 Q26          Et       Me             G3 Q158         Et       Et             G3 Q5           Et       Pri            G3 Q1           Et       COMe           G3 Q2           Et       COEt           G3 Q9           Et       CN             G3 Q23          Et       COMe           G3 Q96          Et       COMe           G3 Q124         Et       COEt           G3 Q135         Et       COPri          G3 Q138         Et       CN             G3 Q5           Et       CH.sub.2 CH.sub.2 Cl G3 Q26          Et       CH.sub.2 CH.sub.2 Cl G3 Q158         Et       CF.sub.3       G3 Q5           Et       Ph             G3 Q26          Et       Ph             G3 Q158         Et       Ph2-Me         G3 Q26          Et       Cl             G3 Q61          Et       Cl             G3 Q5           Et       Br             G3 Q1           Et       Ph             G3 Q2           Et       Cl             G3 Q9           Et       Ph             G3 Q5           Et       NO.sub.2       G3 Q5           Et       NH.sub.2       G3 Q5           Et       NHMe           G3 Q26          Et       NMe.sub.2      G3 Q61          Et       NHCOMe         G3 Q158         Et       NHSO.sub.2 Me  G3 Q2           Et       NHCOMe         G3 Q23          Et       OMe            G3 Q32          Et       NHCOMe         G3 Q96          Et       NMe.sub.2      G3 Q26          Et       SO.sub.2 Me    G3 Q61          Et       SO.sub.2 Me    G3 Q5           Et       SO.sub.2 Ph    G3 Q26          Et       SO.sub.2 OMe   G3 Q61          Et       SO.sub.2 NH.sub.2 G3 Q5           Et       SO.sub.2 NHMe  G3 Q26          Et       SO.sub.2 NMe.sub.2 G3 Q4           Et       SO.sub.2 NHMe  G3 Q7           Et       SO.sub.2 NMe.sub.2 G3 Q9           Et       SO.sub.2 Me    G3 Q142         Et       SO.sub.2 Me    G3 Q159         Et       SO.sub.2 NMe.sub.2 G3 Q5           Cl       COOMe          G3 Q26          Cl       COOMe          G3 Q61          Cl       COOMe          G3 Q5           Cl       COOEt          G3 Q26          Cl       COOEt          G3 Q61          Cl       COOEt          G3 Q96          Cl       COOEt          G3 Q158         Cl       COOEt          G3 Q61          Cl       COOPri         G3 Q5           Cl       COMe           G3 Q158         Cl       COEt           G3 Q5           Cl       COPri          G3 Q26          Cl       CN             G3 Q61          Cl       H              G3 Q26          Cl       Me             G3 Q158         Cl       Et             G3 Q5           Cl       Pri            G3 Q1           Cl       COMe           G3 Q26          Cl       CH.sub.2 CH.sub.2 Cl G3 Q158         Cl       CF.sub.3       G3 Q5           Cl       Ph             G3 Q26          Cl       Cl             G3 Q5           Cl       Br             G3 Q2           Cl       Cl             G3 Q9           Cl       Ph             G3 Q5           Cl       NO.sub.2       G3 Q5           Cl       NH.sub.2       G3 Q5           Cl       NHMe           G3 Q26          Cl       NMe.sub.2      G3 Q61          Cl       NHCOMe         G3 Q158         Cl       NHSO.sub.2 Me  G3 Q2           Cl       NHCOMe         G3 Q26          Cl       SO.sub.2 Me    G3 Q61          Cl       SO.sub.2 Me    G3 Q5           Cl       SO.sub.2 Ph    G3 Q61          Cl       SO.sub.2 NH.sub.2 G3 Q5           Cl       SO.sub.2 NHMe  G3 Q26          Cl       SO.sub.2 NMe.sub.2 G3 Q5           Br       COOMe          G3 Q26          Br       COOMe          G3 Q61          Br       COOMe          G3 Q5           Br       COOEt          G3 Q26          Br       COOEt          G3 Q61          Br       COOEt          G3 Q61          Br       COOPri         G3 Q5           Br       COMe           G3 Q158         Br       COEt           G3 Q26          Br       CN             G3 Q26          Br       Me             G3 Q158         Br       Et             G3 Q26          Br       CH.sub.2 CH.sub.2 Cl G3 Q158         Br       CF.sub.3       G3 Q5           Br       Ph             G3 Q26          Br       Cl             G3 Q5           Br       Br             G3 Q5           Br       NO.sub.2       G3 Q5           Br       NH.sub.2       G3 Q26          Br       NMe.sub.2      G3 Q61          Br       NHCOMe         G3 Q61          Br       SO.sub.2 Me    G3 Q5           Br       SO.sub.2 Ph    G3 Q61          Br       SO.sub.2 NH.sub.2 G3 Q26          Br       SO.sub.2 NMe.sub.2 G3 Q5           SMe      COOMe          G3 Q26          SMe      COOMe          G3 Q61          SMe      COOMe          G3 Q5           SMe      COOEt          G3 Q26          SMe      COOEt          G3 Q61          SMe      COOEt          G3 Q61          SMe      COOPri         G3 Q5           SMe      COMe           G3 Q158         SMe      COEt           G3 Q26          SMe      CN             G3 Q26          SMe      Me             G3 Q158         SMe      Et             G3 Q26          SMe      CH.sub.2 CH.sub.2 Cl G3 Q158         SMe      CF.sub.3       G3 Q5           SMe      Ph             G3 Q26          SMe      Cl             G3 Q5           SMe      Br             G3 Q5           SMe      NO.sub.2       G3 Q5           SMe      NH.sub.2       G3 Q26          SMe      NMe.sub.2      G3 Q61          SMe      NHCOMe         G3 Q61          SMe      SO.sub.2 Me    G3 Q5           SMe      SO.sub.2 Ph    G3 Q61          SMe      SO.sub.2 NH.sub.2 G3 Q26          SMe      SO.sub.2 NMe.sub.2 G3 Q5           SO.sub.2 Me COOMe          G3 Q26          SO.sub.2 Me COOMe          G3 Q61          SO.sub.2 Me COOMe          G3 Q5           SO.sub.2 Me COOEt          G3 Q26          SO.sub.2 Me COOEt          G3 Q61          SO.sub.2 Me COOEt          G3 Q96          SO.sub.2 Me COOEt          G3 Q158         SO.sub.2 Me COOEt          G3 Q61          SO.sub.2 Me COOPr i        G3 Q5           SO.sub.2 Me COMe           G3 Q158         SO.sub.2 Me COEt           G3 Q5           SO.sub.2 Me COPri          G3 Q26          SO.sub.2 Me CN             G3 Q61          SO.sub.2 Me H              G3 Q26          SO.sub.2 Me Me             G3 Q158         SO.sub.2 Me Et             G3 Q5           SO.sub.2 Me Pri            G3 Q1           SO.sub.2 Me COMe           G3 Q26          SO.sub.2 Me CH.sub.2 CH.sub.2 Cl G3 Q158         SO.sub.2 Me CF.sub.3       G3 Q5           SO.sub.2 Me Ph             G3 Q26          SO.sub.2 Me Cl             G3 Q5           SO.sub.2 Me Br             G3 Q2           SO.sub.2 Me Cl             G3 Q9           SO.sub.2 Me Ph             G3 Q5           SO.sub.2 Me NO.sub.2       G3 Q5           SO.sub.2 Me NH.sub.2       G3 Q5           SO.sub.2 Me NHMe           G3 Q26          SO.sub.2 Me NMe.sub.2      G3 Q61          SO.sub.2 Me NHCOMe         G3 Q158         SO.sub.2 Me NHSO.sub.2 Me  G3 Q2           SO.sub.2 Me NHCOMe         G3 Q26          SO.sub.2 Me SO.sub.2 Me    G3 Q61          SO.sub.2 Me SO.sub.2 Me    G3 Q5           SO.sub.2 Me SO.sub.2 Ph    G3 Q61          SO.sub.2 Me SO.sub.2 NH.sub.2 G3 Q5           SO.sub.2 Me SO.sub.2 NHMe  G3 Q26          SO.sub.2 Me SO.sub.2 NMe.sub. 2 G3 Q5           Ph       COOMe          G3 Q26          Ph       COOMe          G3 Q61          Ph       COOMe          G3 Q5           Ph       COOEt          G3 Q26          Ph       COOEt          G3 Q61          Ph       COOEt          G3 Q61          Ph       COOPri         G3 Q5           Ph       COMe           G3 Q158         Ph       COEt           G3 Q26          Ph       CN             G3 Q26          Ph       Me             G3 Q158         Ph       Et             G3 Q26          Ph       CH.sub.2 CH.sub.2 Cl G3 Q158         Ph       CF.sub.3       G3 Q5           Ph       Ph             G3 Q26          Ph       Cl             G3 Q5           Ph       Br             G3 Q5           Ph       NO.sub.2       G3 Q5           Ph       NH.sub.2       G3 Q26          Ph       NMe.sub.2      G3 Q61          Ph       NHCOMe         G3 Q61          Ph       SO.sub.2 Me    G3 Q5           Ph       SO.sub.2 Ph    G3 Q61          Ph       SO.sub.2 NH.sub.2 G3 Q26          Ph       SO.sub.2 NMe.sub.2 G3 Q201         H        COOMe          Ga CH.sub.2 - Q201 H        COOMe          Gb CHMe - Q201  H        COOMe          Gb Q202         H        COOMe          Gb CH.sub.2 - Q202 H        COOMe          Gb Q203         H        COOMe          Gb Q204         H        COOMe          Gb Q205         H        COOMe          Gb CH.sub.2 - Q205 H        COOMe          Gc Q206         H        COOMe          G.sub.3 Q207         H        COOMe          Gc Q208         H        COOMe          G.sub.3 Q209         H        COOMe          Gc CH.sub.2 - Q209 H        COOMe          Gc Q210         H        COOMe          Gc CH.sub.2 - Q210 H        COOMe          G.sub.3 Q211         H        COOMe          G.sub.3 Q212         H        COOMe          Gc Q213         H        COOMe          Gc Q214         H        COOMe          Gc Q215         H        COOMe          G.sub.1 Q216         H        COOMe          Gc Q217         H        COOMe          Gc Q218         H        COOMe          G.sub.3 Q219         H        COOMe          Gc Q220         H        COOMe          Gc Q221         H        COOMe          G.sub.2 Q222         H        COOMe          Gb CH.sub.2 - Q222 H        COOMe          Gc Q223         H        COOMe          Gc Q224         H        COOMe          G.sub.3 Q225         H        COOMe          Gb CH.sub.2 - Q225 H        COOMe          Gc Q226         H        COOMe          G.sub.3 Q227         H        COOMe          Gc Q228         H        COOMe          Gc Q229         H        COOMe          Gb CH.sub.2 - Q229 H        COOMe          Gc Q230         H        COOMe          Gc Q231         H        COOMe          Gc Q232         H        COOMe          G.sub.3 Q233         H        COOMe          Gc Q234         H        COOMe          Gc Q235         H        COOMe          Gc Q236         H        COOMe          G.sub.3 Q237         H        COOMe          Gc Q238         H        COOMe          Gc Q239         H        COOMe          G.sub.2 Q240         H        COOMe          Gc Q241         H        COOMe          Gc Q242         H        COOMe          Gc Q243         H        COOMe          G.sub.1 Q244         H        COOMe          Gc Q245         H        COOMe          Gc Q246         H        COOMe          Gb CH.sub.2 - Q246 H        COOMe          Gc Q247         H        COOMe          G.sub. 3 Q248         H        COOMe          Gc Q249         H        COOMe          Gc Q250         H        COOMe          Gc CH.sub.2 - Q250 H        COOMe          G.sub.3 Q251         H        COOMe          Gc Q252         H        COOMe          Gc Q253         H        COOMe          Gc Q254         H        COOMe          G.sub.1 Q255         H        COOMe          Gc Q256         H        COOMe          Gc Q257         H        COOMe          G.sub.3 Q258         H        COOMe          Gc Q259         H        COOMe          Gc CH.sub.2 - Q259 H        COOMe          Gc Q260         H        COOMe          Gc CH.sub.2 - Q260 H        COOMe          Gc Q261         H        COOMe          G.sub.1 Q262         H        COOMe          Gc Q263         H        COOMe          Gc Q264         H        COOMe          G.sub.2 Q201         H        COOEt          Ga CH.sub.2 - Q201 H        COOEt          Gb CHMe - Q201  H        COOEt          Gb Q202         H        COOEt          Gb CH.sub.2 - Q202 H        COOEt          Gb Q203         H        COOEt          Gb Q204         H        COOEt          Gb Q205         H        COOEt          Gb CH.sub.2 - Q205 H        COOEt          Gc Q206         H        COOEt          G.sub.3 Q207         H        COOEt          Gc Q208         H        COOEt          G.sub.3 Q209         H        COOEt          Gc CH.sub.2 - Q209 H        COOEt          Gc Q210         H        COOEt          Gc CH.sub.2 - 210 H        COOEt          G.sub.3 Q211         H        COOEt          Gc Q212         H        COOEt          Gc Q213         H        COOEt          Gc Q214         H        COOEt          G.sub.1 Q215         H        COOEt          Gc Q216         H        COOEt          Gc Q217         H        COOEt          G.sub.2 Q218         H        COOEt          Gc Q219         H        COOEt          Gc Q220         H        COOEt          G.sub.3 Q221         H        COOEt          Gc Q222         H        COOEt          Gb CH.sub.2 - Q222 H        COOEt          Gc Q223         H        COOEt          Gc Q224         H        COOEt          Gc Q225         H        COOEt          Gb CH.sub.2 - Q225 H        COOEt          Gc Q226         H        COOEt          G.sub.3 Q227         H        COOEt          Gc Q228         H        COOEt          Gc Q229         H        COOEt          Gb CH.sub.2 - Q229 H        COOEt          Gc Q230         H        COOEt          Gc Q231         H        COOEt          Gc Q232         H        COOEt          G.sub.3 Q233         H        COOEt          Gc Q234         H        COOEt          Gc CH.sub.2 - Q234 H        COOEt          Gc Q235         H        COOEt          Gc Q236         H        COOEt          G.sub.3 Q237         H        COOEt          Gc Q238         H        COOEt          Gc Q239         H        COOEt          Gc Q240         H        COOEt          G.sub.1 Q241         H        COOEt          Gc Q242         H        COOEt          Gc Q243         H        COOEt          Gc Q244         H        COOEt          G.sub.2 Q245         H        COOEt          Gc Q246         H        COOEt          Gb CH.sub.2 - Q246 H        COOEt          Gc Q247         H        COOEt          Gc Q248         H        COOEt          Gc Q249         H        COOEt          G.sub.3 Q250         H        COOEt          Gc CH.sub.2  - Q250 H        COOEt          Gc Q251         H        COOEt          Gc Q252         H        COOEt          G.sub.3 Q253         H        COOEt          Gc Q254         H        COOEt          Gc Q255         H        COOEt          Gc Q256         H        COOEt          Gc Q257         H        COOEt          Gc Q258         H        COOEt          G.sub.1 Q259         H        COOEt          Gc CH.sub.2 - Q259 H        COOEt          Gc Q260         H        COOEt          Gc CH.sub.2 - Q260 H        COOEt          Gc Q261         H        COOEt          G.sub.3 Q262         H        COOEt          Gc Q263         H        COOEt          Gc Q264         H        COOEt          G.sub.3 Q201         H        COOH           Gc Q202         H        COOH           Gc Q222         H        COOH           Gc Q225         H        COOH           G.sub.3 Q229         H        COOH           Gc Q246         H        COOH           G.sub.3 Q201         H        COOPri         Gc Q202         H        COOPri         G.sub.3 Q205         H        COOPri         Gc Q209         H        COOPri         Gc Q222         H        COOPri         Gc Q225         H        COOPri         Gc Q229         H        COOPri         G.sub.3 Q246         H        COOPri         Gc Q201         H        COOCH.sub.2 CH.sub.2 Cl Gc Q202         H        COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q205         H        COOCH.sub.2 CH.sub.2 Cl Gc Q209         H        COOCH.sub.2 CH.sub.2 Cl Gc Q222         H        COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q225         H        COOCH.sub.2 CH.sub.2 Cl Gc Q229         H        COOCH.sub.2 CH.sub.2 Cl Gc Q246         H        COOCH.sub.2 CH.sub.2 Cl G.sub.1 Q201         H        COOCH.sub.2 CHCH.sub.2 Gc Q202         H        COOCH.sub.2 CHCH.sub.2 Gc Q205         H        COOCH.sub.2 CHCH.sub.2 G.sub.3 Q209         H        COOCH.sub.2 CHCH.sub.2 Gc Q222         H        COOCH.sub.2 CHCH.sub.2 Gc Q225         H        COOCH.sub.2 CHCH.sub.2 Gc Q229         H        COOCH.sub.2 CHCH.sub.2 G.sub.3 Q246         H        COOCH.sub.2 CHCH.sub.2 Gc Q201         H        COOCH.sub.2 CCH Gc Q202         H        COOCH.sub.2 CCH G.sub.3 Q205         H        COOCH.sub.2 CCH Gc Q209         H        COOCH.sub.2 CCH Gc Q222         H        COOCH.sub.2 CCH Gc Q225         H        COOCH.sub.2 CCH G.sub.3 Q229         H        COOCH.sub.2 CCH Gc Q246         H        COOCH.sub.2 CCH G.sub.3 Q201         H        CONHMe         Gc Q202         H        CONHMe         G.sub.3 Q205         H        CONHMe         Gc Q209         H        CONHMe         Gc Q222         H        CONHMe         G.sub.3 Q225         H        CONHMe         Gc Q229         H        CONHMe         Gc Q246         H        CONHMe         G.sub.3 Q201         H        CONMe.sub.2    Gc Q202         H        CONMe.sub.2    G.sub.3 Q205         H        CONMe.sub.2    Gc Q209         H        CONMe.sub.2    Gc Q222         H        CONMe.sub.2    Gc Q225         H        CONMe.sub.2    G.sub.3 Q229         H        CONMe.sub.2    Gc Q246         H        CONMe.sub.2    G.sub.2 Q201         H        COMe           Gc CH.sub.2 - Q201 H        COMe           G.sub.3 Q202         H        COMe           G.sub.3 Q205         H        COMe           Gc Q207         H        COMe           G.sub.3 Q222         H        COMe           Gc Q225         H        COMe           Gc Q229         H        COMe           Gc Q230         H        COMe           G.sub.2 Q231         H        COMe           G.sub.3 Q237         H        COMe           Gc Q246         H        COMe           Gc Q247         H        COMe           G.sub.3 Q250         H        COMe           Gc Q259         H        COMe           Gc Q260         H        COMe           Gc Q263         H        COMe           G.sub.3 Q201         H        COEt           Gc Q202         H        COEt           G.sub.3 Q205         H        COEt           Gc Q209         H        COEt           Gc Q222         H        COEt           Gc Q225         H        COEt           G.sub.3 Q229         H        COEt           Gc Q246         H        COEt           G.sub.3 Q201         H        COPri          Gc Q202         H        COPri          G.sub.3 Q205         H        COPri          Gc Q209         H        COPri          Gc Q222         H        COPri          Gc Q225         H        COPri          G.sub.3 Q229         H        COPri          Gc Q246         H        COPri          Gc Q201         H        COPh           Gc Q202         H        COPh           G.sub.3 Q205         H        COPh           Gc Q209         H        COPh           Gc Q222         H        COPh           G.sub.3 Q225         H        COPh           Gc Q229         H        COPh           Gc Q246         H        COPh           G.sub.3 Q201         H        CN             Gc CH.sub.2 - Q201 H        CN             G.sub.3 Q202         H        CN             Gc Q205         H        CN             Gc Q209         H        CN             Gc Q222         H        CN             Gc Q225         H        CN             Gc Q229         H        CN             Gc Q246         H        CN             G.sub.3 Q201         H        H              Gc Q202         H        H              G.sub.3 Q205         H        H              Gc Q207         H        H              Gc Q222         H        H              Gc Q225         H        H              G.sub.3 Q229         H        H              Gc Q230         H        H              Gc Q231         H        H              G.sub.3 Q237         H        H              Gc Q246         H        H              Gc Q247         H        H              G.sub.3 Q250         H        H              Gc Q259         H        H              G.sub.3 Q260         H        H              Gc Q263         H        H              G.sub.3 Q201         H        Me             Gc Q202         H        Me             G.sub.3 Q205         H        Me             Gc Q207         H        Me             G.sub.3 Q222         H        Me             Gc Q225         H        Me             Gc Q229         H        Me             Gc Q230         H        Me             G.sub.3 Q231         H        Me             Gc Q237         H        Me             Gc Q246         H        Me             Gc Q247         H        Me             G.sub.3 Q250         H        Me             Gc Q259         H        Me             Gc Q260         H        Me             Gc Q263         H        Me             G.sub.3 Q201         H        Et             Gc Q202         H        Et             G.sub.1 Q205         H        Et             Gc Q209         H        Et             Gc Q222         H        Et             G.sub.3 Q225         H        Et             Gc Q229         H        Et             Gc Q246         H        Et             G.sub.2 Q201         H        Pri            Gc Q205         H        Pri            Gc Q209         H        Pri            Gc Q222         H        Pri            G.sub.3 Q229         H        Pri            Gc Q201         H        CHCH.sub.2     Gc Q205         H        CHCH.sub.2     G.sub.3 Q209         H        CHCH.sub.2     Gc Q229         H        CHCH.sub.2     G.sub.3 Q201         H        CHCHMe         Gc Q205         H        CHCHMe         Gc Q201         H        CH.sub.2 CHCH.sub.2 Gc Q205         H        CH.sub.2 CHCH.sub.2 G.sub.3 Q209         H        CH.sub.2 CHCH.sub.2 Gc Q229         H        CH.sub.2 CHCH.sub.2 Gc Q201         H        CH.sub.2 Cl    Gc Q205         H        CH.sub.2 Cl    G.sub.3 Q209         H        CH.sub.2 Cl    Gc Q229         H        CH.sub.2 Cl    Gc Q201         H        CH.sub.2 CH.sub.2 Cl Gc Q205         H        CH.sub.2 CH.sub.2 Cl G.sub.3 Q209         H        CH.sub.2 CH.sub.2 Cl Gc Q229         H        CH.sub.2 CH.sub.2 Cl G.sub.2 Q201         H        CF.sub.3       Gc Q205         H        CF.sub.3       G.sub.3 Q209         H        CF.sub.3       Gc Q222         H        CF.sub.3       Gc Q225         H        CF.sub.3       G.sub.3 Q229         H        CF.sub.3       G.sub.1 Q201         H        CFCFCl         Gc Q205         H        CFCFCl         Gc Q229         H        CFCFCl         G.sub.3 Q201         H        CH.sub.2 Ph    Gc Q205         H        CH.sub.2 Ph    Gc Q209         H        CH.sub.2 Ph    G.sub.3 Q201         H        Ph             Gc Q202         H        Ph             G.sub.1 Q205         H        Ph             Gc Q209         H        Ph             Gc Q222         H        Ph             G.sub.3 Q225         H        Ph             Gc Q229         H        Ph             Gc Q246         H        Ph             G.sub.2 Q201         H        Ph2-Cl         Gc Q205         H        Ph2-Cl         G.sub.1 Q209         H        Ph2-Cl         Gc Q201         H        Ph2-Me         Gc Q205         H        Ph2-Me         G.sub.3 Q209         H        Ph2-Me         Gc Q225         H        Ph2-Me         Gc Q229         H        Ph2-Me         G.sub.3 Q201         H        Cl             Gc Q205         H        Cl             Gc Q207         H        Cl             G.sub.3 Q222         H        Cl             Gc Q225         H        Cl             Gc Q229         H        Cl             G.sub.1 Q231         H        Cl             Gc Q246         H        Cl             Gc Q250         H        Cl             G.sub.3 Q259         H        Cl             Gc Q260         H        Cl             Gc Q201         H        Br             Gc Q205         H        Br             G.sub.3 Q207         H        Br             Gc Q229         H        Br             Gc Q231         H        Br             G.sub.3 Q250         H        Br             Gc Q259         H        Br             Gc Q260         H        Br             G.sub.3 Q201         H        F              Gc Q205         H        F              G.sub.3 Q209         H        F              Gc Q229         H        F              Gc Q246         H        F              G.sub.3 Q201         H        I              Gc Q205         H        I              Gc Q209         H        I              Gc Q222         H        I              Gc Q201         H        NO.sub.2       Gc CH.sub.2 - Q201 H        NO.sub.2       G.sub.3 Q202         H        NO.sub.2       G.sub.3 Q205         H        NO.sub.2       Gc Q207         H        NO.sub.2       Gc Q222         H        NO.sub.2       G.sub.3 Q225         H        NO.sub.2       Gc Q229         H        NO.sub.2       Gc Q230         H        NO.sub.2       G.sub.1 Q231         H        NO.sub.2       Gc Q237         H        NO.sub.2       Gc Q246         H        NO.sub.2       Gc Q247         H        NO.sub.2       G.sub.2 Q250         H        NO.sub.2       Gc Q259         H        NO.sub.2       Gc Q260         H        NO.sub.2       G.sub.3 Q263         H        NO.sub.2       Gc Q201         H        NH.sub. 2      Gc Q202         H        NH.sub.2       G.sub.3 Q205         H        NH.sub.2       Gc Q209         H        NH.sub.2       Gc Q222         H        NH.sub.2       G.sub.3 Q225         H        NH.sub.2       Gc Q229         H        NH.sub.2       Gc Q246         H        NH.sub.2       G.sub.3 Q201         H        NHMe           Gc Q205         H        NHMe           Gc Q209         H        NHMe           Gc Q225         H        NHMe           Gc Q229         H        NHMe           G.sub.3 Q201         H        NMe.sub.2      Gc Q205         H        NMe.sub.2      Gc Q209         H        NMe.sub.2      Gc Q222         H        NMe.sub.2      G.sub.1 Q225         H        NMe.sub.2      Gc Q229         H        NMe.sub.2      Gc Q246         H        NMe.sub.2      G.sub.3 Q201         H        NMeEt          Gc Q205         H        NMeEt          Gc Q209         H        NMeEt          G.sub.3 Q222         H        NMeEt          Gc Q225         H        NMeEt          Gc Q229         H        NMeEt          G.sub.2 Q201         H        NHCOMe         Gc Q202         H        NHCOMe         G.sub.3 Q205         H        NHCOMe         Gc Q209         H        NHCOMe         Gc Q222         H        NHCOMe         G.sub.3 Q225         H        NHCOMe         Gc Q229         H        NHCOMe         Gc Q246         H        NHCOMe         G.sub.3 Q201         H        NHCOEt         Gc Q205         H        NHCOEt         Gc Q209         H        NHCOEt         Gc Q222         H        NHCOEt         G.sub.1 Q225         H        NHCOEt         Gc Q229         H        NHCOEt         G.sub.3 Q201         H        NHSO.sub.2 Me  Gc Q205         H        NHSO.sub.2 Me  Gc Q209         H        NHSO.sub. 2 Me Gc Q225         H        NHSO.sub.2 Me  G.sub.3 Q229         H        NHSO.sub.2 Me  G.sub.3 Q201         H        OMe            Gc Q205         H        OMe            Gc Q209         H        OMe            G.sub.3 Q222         H        OMe            Gc Q225         H        OMe            Gc Q229         H        OMe            G.sub.2 Q246         H        OMe            G.sub.1 Q201         H        OEt            Gc Q205         H        OEt            Gc Q209         H        OEt            Gc Q222         H        OEt            G.sub.3 Q229         H        OEt            Gc Q201         H        CH.sub.2 OMe   Gc Q205         H        CH.sub.2 OMe   Gc Q209         H        CH.sub.2 OMe   G.sub.3 Q222         H        CH.sub.2 OMe   Gc Q201         H        SMe            Gc Q205         H        SMe            Gc Q209         H        SMe            Gc Q222         H        SMe            G.sub.1 Q225         H        SMe            Gc Q229         H        SMe            G.sub.3 Q201         H        SO.sub.2 Me    Gc CH.sub.2 - Q201 H        SO.sub.2 Me    G.sub.3 Q202         H        SO.sub.2 Me    Gc Q205         H        SO.sub.2 Me    Gc Q209         H        SO.sub.2 Me    Gc Q222         H        SO.sub.2 Me    G.sub.3 Q225         H        SO.sub.2 Me    Gc Q229         H        SO.sub.2 Me    Gc Q246         H        SO.sub.2 Me    G.sub.3 Q201         H        SO.sub.2 Ph    Gc Q202         H        SO.sub.2 Ph    G.sub.1 Q205         H        SO.sub.2 Ph    Gc Q209         H        SO.sub.2 Ph    Gc Q222         H        SO.sub.2 Ph    Gc Q225         H        SO.sub.2 Ph    G.sub.3 Q229         H        SO.sub.2 Ph    Gc Q246         H        SO.sub.2 Ph    G.sub.1 Q201         H        SO.sub.2 OMe   Gc Q205         H        SO.sub.2 OMe   Gc Q209         H        SO.sub.2 OMe   Gc Q222         H        SO.sub.2 OMe   Gc Q229         H        SO.sub.2 OMe   G.sub.3 Q201         H        SO.sub.2 NH.sub.2 Gc Q205         H        SO.sub.2 NH.sub.2 Gc Q209         H        SO.sub.2 NH.sub.2 G.sub.3 Q225         H        SO.sub.2 NH.sub.2 Gc Q229         H        SO.sub.2 NH.sub.2 Gc Q246         H        SO.sub.2 NH.sub.2 G.sub.1 Q201         H        SO.sub.2 NHMe  Gc Q205         H        SO.sub.2 NHMe  Gc Q209         H        SO.sub.2 NHMe  G.sub.3 Q222         H        SO.sub.2 NHMe  Gc Q225         H        SO.sub.2 NHMe  Gc Q229         H        SO.sub.2 NHMe  Gc Q246         H        SO.sub.2 NHMe  G.sub.2 Q201         H        SO.sub.2 NMe.sub.2 Gc Q202         H        SO.sub.2 NMe.sub.2 G.sub.3 Q205         H        SO.sub.2 NMe.sub.2 Gc Q209         H        SO.sub.2 NMe.sub.2 Gc Q222         H        SO.sub.2 NMe.sub.2 G.sub.2 Q225         H        SO.sub.2 NMe.sub.2 Gc Q229         H        SO.sub.2 NMe.sub. 2 Gc Q246         H        SO.sub.2 NMe.sub.2 G.sub.3 Q201         Me       COOMe          Gc CH.sub.2 - Q201 Me       COOMe          G.sub.3 Q201         Me       COOMe          G.sub.1 Q205         Me       COOMe          Gc Q207         Me       COOMe          G.sub.3 Q209         Me       COOMe          Gc Q222         Me       COOMe          Gc Q225         Me       COOMe          G.sub.2 Q229         Me       COOMe          Gc Q230         Me       COOMe          Gc Q231         Me       COOMe          G.sub.3 Q237         Me       COOMe          Gc Q246         Me       COOMe          Gc Q247         Me       COOMe          G.sub.3 Q250         Me       COOMe          Gc Q259         Me       COOMe          G.sub.1 Q260         Me       COOMe          Gc Q263         Me       COOMe          G.sub.3 Q201         Me       COOEt          Gc CH.sub.2 - Q201 Me       COOEt          G.sub.2 Q222         Me       COOEt          Gc Q205         Me       COOEt          Gc Q207         Me       COOEt          G.sub.3 Q209         Me       COOEt          Gc Q222         Me       COOEt          Gc Q225         Me       COOEt          G.sub.3 Q229         Me       COOEt          Gc Q230         Me       COOEt          Gc Q231         Me       COOEt          Gc Q237         Me       COOEt          G.sub.1 Q246         Me       COOEt          Gc Q247         Me       COOEt          Gc Q250         Me       COOEt          Gc Q259         Me       COOEt          G.sub.3 Q260         Me       COOEt          Gc Q263         Me       COOEt          G.sub.3 Q201         Me       COOH           G.sub.1 Q205         Me       COOH           Gc Q201         Me       COOPri         Gc Q202         Me       COOPri         G.sub.3 Q205         Me       COOPri         Gc Q209         Me       COOPri         Gc Q222         Me       COOPri         G.sub.3 Q225         Me       COOPri         Gc Q229         Me       COOPri         Gc Q246         Me       COOPri         G.sub.1 Q201         Me       COOCH.sub.2 CH.sub.2 Cl Gc Q205         Me       COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q222         Me       COOCH.sub.2 CH.sub.2 Cl Gc Q229         Me       COOCH.sub.2 CH.sub.2 Cl G.sub.1 Q201         Me       COOCH.sub.2 CHCH.sub.2 Gc Q205         Me       COOCH.sub.2 CHCH.sub.2 G.sub.3 Q222         Me       COOCH.sub.2 CHCH.sub.2 Gc Q229         Me       COOCH.sub.2 CHCH.sub.2 G.sub.1 Q201         Me       COOCH.sub.2 CCH Gc Q205         Me       COOCH.sub.2 CCH G.sub.2 Q222         Me       COOCH.sub.2 CCH Gc Q229         Me       COOCH.sub.2 CCH Gc Q201         Me       CONHMe         Gc Q205         Me       CONHMe         G.sub.3 Q222         Me       CONHMe         Gc Q229         Me       CONHMe         Gc Q201         Me       CONMe.sub.2    Gc Q205         Me       CONMe.sub.2    G.sub.3 Q222         Me       CONMe.sub.2    Gc Q229         Me       CONMe.sub.2    Gc Q201         Me       COMe           Gc Q202         Me       COMe           G.sub.3 Q205         Me       COMe           Gc Q207         Me       COMe           Gc Q222         Me       COMe           G.sub.3 Q225         Me       COMe           Gc Q229         Me       COMe           Gc Q230         Me       COMe           G.sub.3 Q231         Me       COMe           Gc Q237         Me       COMe           Gc Q246         Me       COMe           Gc Q247         Me       COMe           G.sub.2 Q250         Me       COMe           Gc Q259         Me       COMe           Gc Q260         Me       COMe           G.sub.1 Q263         Me       COMe           Gc Q201         Me       COEt           Gc Q205         Me       COEt           G.sub.3 Q222         Me       COEt           Gc Q229         Me       COEt           Gc Q201         Me       COPri          Gc Q205         Me       COPri          G.sub.3 Q222         Me       COPri          Gc Q229         Me       COPri          G.sub.1 Q201         Me       COPh           Gc Q205         Me       COPh           Gc Q222         Me       COPh           G.sub.3 Q229         Me       COPh           Gc Q201         Me       CN             Gc Q202         Me       CN             G.sub.3 Q205         Me       CN             Gc Q209         Me       CN             Gc Q222         Me       CN             G.sub.3 Q225         Me       CN             Gc Q229         Me       CN             Gc Q246         Me       CN             G.sub.1 Q201         Me       H              Gc Q205         Me       H              Gc Q222         Me       H              G.sub.3 Q229         Me       H              Gc Q201         Me       Me             Gc Q202         Me       Me             G.sub.3 Q205         Me       Me             Gc Q209         Me       Me             Gc Q222         Me       Me             Gc Q225         Me       Me             Gc Q229         Me       Me             G.sub.3 Q246         Me       Me             Gc Q201         Me       Et             Gc Q205         Me       Et             Gc Q222         Me       Et             G.sub.3 Q229         Me       Et             Gc Q201         Me       Pri            Gc Q205         Me       Pri            G.sub.2 Q201         Me       CHCH.sub.2     Gc Q205         Me       CHCH.sub.2     G.sub.3 Q201         Me       CHCHMe         G.sub.3 Q205         Me       CHCHMe         Gc Q201         Me       CH.sub.2 CHCH.sub.2 Gc Q205         Me       CH.sub.2 CHCH.sub.2 G.sub.3 Q201         Me       CH.sub.2 Cl    Gc Q205         Me       CH.sub.2 Cl    G.sub.2 Q222         Me       CH.sub.2 Cl    Gc Q229         Me       CH.sub.2 Cl    G.sub.3 Q201         Me       CH.sub.2 CH.sub.2 Cl Gc Q205         Me       CH.sub.2 CH.sub.2 Cl Gc Q222         Me       CH.sub.2 CH.sub.2 Cl G.sub.3 Q229         Me       CH.sub.2 CH.sub.2 Cl Gc Q201         Me       CF.sub.3       Gc Q205         Me       CF.sub.3       G.sub.3 Q222         Me       CF.sub.3       G.sub.3 Q229         Me       CF.sub.3       Gc Q201         Me       CFCFCl         Gc Q205         Me       CFCFCl         G.sub.3 Q201         Me       CH.sub.2 Ph    Gc Q205         Me       CH.sub.2 Ph    G.sub.3 Q201         Me       Ph             Gc Q202         Me       Ph             Gc Q205         Me       Ph             Gc Q209         Me       Ph             Gc Q222         Me       Ph             G.sub.3 Q225         Me       Ph             G.sub.3 Q229         Me       Ph             Gc Q246         Me       Ph             G.sub.3 Q201         Me       Ph2-Cl         Gc Q205         Me       Ph2-Cl         G.sub.3 Q201         Me       Ph2-Me         Gc Q205         Me       Ph2-Me         Gc Q229         Me       Ph2-Me         G.sub.3 Q201         Me       Cl             Gc Q202         Me       Cl             G.sub.3 Q205         Me       Cl             Gc Q209         Me       Cl             Gc Q222         Me       Cl             G.sub.3 Q225         Me       Cl             Gc Q229         Me       Cl             Gc Q246         Me       Cl             G.sub.3 Q201         Me       Br             Gc Q205         Me       Br             G.sub.3 Q222         Me       Br             Gc Q229         Me       Br             G.sub.1 Q201         Me       F              G.sub.1 Q205         Me       F              G.sub.1 Q201         Me       I              G.sub.1 Q205         Me       I              G.sub.1 Q201         Me       NO.sub.2       Gc Q202         Me       NO.sub.2       G.sub.3 Q205         Me       NO.sub.2       Gc Q209         Me       NO.sub.2       Gc Q222         Me       NO.sub.2       Gc Q225         Me       NO.sub.2       G.sub.3 Q229         Me       NO.sub.2       Gc Q246         Me       NO.sub.2       Gc Q201         Me       NH.sub.2       Gc Q205         Me       NH.sub.2       G.sub.3 Q222         Me       NH.sub.2       Gc Q229         Me       NH.sub.2       G.sub.3 Q201         Me       NHMe           Gc Q205         Me       NHMe           Gc Q229         Me       NHMe           G.sub.3 Q201         Me       NMe.sub.2      Gc Q205         Me       NMe.sub.2      Gc Q229         Me       NMe.sub.2      G.sub.3 Q201         Me       NMeEt          Gc Q205         Me       NMeEt          Gc Q201         Me       NHCOMe         Gc Q205         Me       NHCOMe         Gc Q222         Me       NHCOMe         G.sub.3 Q229         Me       NHCOMe         Gc Q201         Me       NHCOEt         Gc Q205         Me       NHCOEt         G.sub.3 Q201         Me       NHSO.sub.2 Me  Gc Q205         Me       NHSO.sub.2 Me  Gc Q229         Me       NHSO.sub.2 Me  G.sub.2 Q201         Me       OMe            Gc Q205         Me       OMe            G.sub.3 Q222         Me       OMe            Gc Q229         Me       OMe            G.sub.1 Q201         Me       OEt            Gc Q205         Me       OEt            G.sub.3 Q201         Me       CH.sub.2 OMe   Gc Q205         Me       CH.sub.2 OMe   Gc Q229         Me       CH.sub.2 OMe   G.sub.3 Q201         Me       SMe            Gc Q205         Me       SMe            G.sub.3 Q201         Me       SO.sub.2 Me    Gc Q205         Me       SO.sub.2 Me    Gc Q222         Me       SO.sub.2 Me    G.sub.1 Q229         Me       SO.sub.2 Me    G.sub.3 Q201         Me       SO.sub.2 Ph    Gc Q205         Me       SO.sub.2 Ph    Gc Q222         Me       SO.sub.2 Ph    G.sub.3 Q229         Me       SO.sub.2 Ph    Gc Q201         Me       SO.sub.2 OMe   Gc Q205         Me       SO.sub.2 OMe   G.sub.3 Q229         Me       SO.sub.2 OMe   Gc Q201         Me       SO.sub.2 NH.sub.2 Gc Q205         Me       SO.sub.2 NH.sub.2 Gc Q229         Me       SO.sub.2 NH.sub.2 G.sub.3 Q201         Me       SO.sub.2 NHMe  Gc Q205         Me       SO.sub.2 NHMe  Gc Q222         Me       SO.sub.2 NHMe  G.sub.1 Q229         Me       SO.sub.2 NHMe  Gc Q201         Me       SO.sub.2 NMe.sub.2 Gc Q205         Me       SO.sub.2 NMe.sub.2 G.sub.3 Q222         Me       SO.sub.2 NMe.sub.2 Gc Q229         Me       SO.sub.2 NMe.sub.2 G.sub.1 Q201         Et       COOMe          Gc Q205         Et       COOMe          Gc Q229         Et       COOMe          G.sub.3 Q246         Et       COOMe          G.sub.3 Q201         Et       COOEt          Gc Q202         Et       COOEt          G.sub.2 Q209         Et       COOEt          Gc Q222         Et       COOEt          G.sub.3 Q225         Et       COOEt          Gc Q201         Et       COOPri         G.sub.3 Q205         Et       COOPri         Gc Q201         Et       COOCH.sub.2 CHCl Gc Q205         Et       COOCH.sub.2 CHCH.sub.2 G.sub.3 Q201         Et       COOCH.sub.2 CCH Gc Q201         Et       CONHMe         Gc Q201         Et       CONMe.sub.2    Gc Q201         Et       COMe           Gc Q205         Et       COMe           G.sub.3 Q229         Et       COMe           Gc Q201         Et       COEt           Gc Q201         Et       COPh           Gc Q201         Et       CN             Gc Q205         Et       CN             G.sub.3 Q229         Et       CN             Gc Q201         Et       H              Gc Q205         Et       H              G.sub.3 Q201         Et       Me             Gc Q205         Et       Me             G.sub.3 Q201         Et       Et             Gc Q205         Et       Pri            Gc Q201         Et       CHCHMe         Gc Q201         Et       CH.sub.2 CH.sub.2 Cl Gc Q201         Et       CH.sub.2 Ph    G.sub.3 Q201         Et       Ph             Gc Q205         Et       Ph             Gc Q209         Et       Ph             Gc Q229         Et       Ph             G.sub.3 Q201         Et       Ph2-Cl         Gc Q205         Et       Ph2-Me         Gc Q201         Et       Cl             Gc Q205         Et       Cl             G.sub.2 Q201         Et       Br             Gc Q205         Et       Br             G.sub.1 Q201         Et       F              Gc Q201         Et       NO.sub.2       Gc Q205         Et       NO.sub.2       G.sub.3 Q209         Et       NO.sub.2       Gc Q201         Et       NH.sub.2       Gc Q201         Et       NHMe           Gc Q201         Et       NMe.sub.2      Gc Q205         Et       NMe.sub.2      G.sub.3 Q201         Et       NHCOMe         Gc Q205         Et       NHCOMe         Gc Q201         Et       NHCOEt         Gc Q201         Et       NHSO.sub.2 Me  Gc Q201         Et       OMe            Gc Q205         Et       OEt            G.sub.3 Q201         Et       CH.sub.2 OMe   Gc Q201         Et       SMe            Gc Q201         Et       SO.sub.2 Me    Gc Q205         Et       SO.sub.2 Me    G.sub.3 Q201         Et       SO.sub.2 Ph    Gc Q205         Et       SO.sub.2 Ph    G.sub.3 Q201         Et       SO.sub.2 OMe   Gc Q201         Et       SO.sub.2 NH.sub.2 Gc Q205         Et       SO.sub.2 NHMe  G.sub.3 Q201         Et       SO.sub. 2 NMe.sub.2 Gc Q205         Et       SO.sub.2 NMe.sub.2 G.sub.3 Q201         Cl       COOMe          Gc Q209         Cl       COOMe          G.sub.3 Q229         Cl       COOMe          Gc Q246         Cl       COOMe          G.sub.3 Q201         Cl       COOEt          Gc Q205         Cl       COOEt          Gc Q222         Cl       COOEt          G.sub.1 Q225         Cl       COOEt          Gc Q246         Cl       COOEt          G.sub.3 Q201         Cl       COOPri         Gc Q205         Cl       COOPri         G.sub.3 Q205         Cl       COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q201         Cl       COOCH.sub.2 CHCH.sub.2 Gc Q201         Cl       COOCH.sub.2 CCH G.sub.3 Q201         Cl       CONHMe         Gc Q201         Cl       CONMe.sub.2    G.sub.3 Q201         Cl       COMe           Gc Q205         Cl       COMe           Gc Q201         Cl       COEt           G.sub.3 Q201         Cl       COPri          Gc Q201         Cl       COPh           G.sub.3 Q201         Cl       CN             Gc Q205         Cl       CN             Gc Q201         Cl       H              G.sub.3 Q201         Cl       Me             Gc Q205         Cl       Me             G.sub.3 Q205         Cl       Et             Gc Q201         Cl       Pri            G.sub.3 Q201         Cl       CHCHMe         Gc Q201         Cl       CH.sub.2 CHCH.sub.2 G.sub.1 Q205         Cl       CH.sub.2 CH.sub.2 Cl Gc Q201         Cl       Ph             Gc Q205         Cl       Ph             Gc Q209         Cl       Ph             G.sub.3 Q201         Cl       Ph2-Cl         Gc Q205         Cl       Ph2-Me         G.sub.3 Q201         Cl       Cl             Gc Q205         Cl       Cl             G.sub.3 Q201         Cl       Br             Gc Q201         Cl       NO.sub.2       Gc Q205         Cl       NO.sub.2       G.sub.3 Q209         Cl       NO.sub.2       Gc Q201         Cl       NH.sub.2       Gc Q201         Cl       NHMe           G.sub.1 Q201         Cl       NMe.sub.2      G.sub.3 Q201         Cl       NHCOMe         Gc Q205         Cl       NHCOEt         Gc Q201         Cl       NHSO.sub.2 Me  G.sub.3 Q201         Cl       OMe            Gc Q201         Cl       CH.sub.2 OMe   G.sub.3 Q201         Cl       SO.sub.2 Me    Gc Q201         Cl       SO.sub.2 Ph    Gc Q201         Cl       SO.sub.2 NH.sub.2 G.sub.3 Q201         Cl       SO.sub.2 NMe.sub.2 Gc Q205         Cl       SO.sub.2 NMe.sub.2 Gc Q201         Br       COOMe          Gc Q205         Br       COOMe          G.sub.3 Q209         Br       COOMe          G.sub.3 Q201         Br       COOEt          Gc Q209         Br       COOEt          Gc Q229         Br       COOEt          G.sub.3 Q201         Br       COOPri         G.sub.3 Q201         Br       COOCH.sub.2 CHCl Gc Q201         Br       COOCH.sub.2 CHCH.sub.2 G.sub.3 Q201         Br       CONHMe         Gc Q201         Br       CONMe.sub.2    G.sub.3 Q201         Br       COMe           Gc Q205         Br       COMe           G.sub.3 Q201         Br       COEt           Gc Q201         Br       COPh           G.sub.3 Q201         Br       CN             Gc Q205         Br       CN             Gc Q201         Br       H              G.sub.3 Q201         Br       Me             G.sub.2 Q201         Br       Et             G.sub.1 Q201         Br       CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         Br       Ph             Gc Q205         Br       Ph             Gc Q209         Br       Ph             G.sub.3 Q201         Br       Ph2-Cl         G.sub.3 Q201         Br       Cl             Gc Q201         Br       Br             Gc Q205         Br       Br             G.sub.3 Q201         Br       NO.sub.2       Gc Q209         Br       NO.sub.2       Gc Q201         Br       NH.sub.2       Gc Q201         Br       NMe.sub.2      G.sub.3 Q201         Br       NHCOMe         Gc Q201         Br       OMe            G.sub.3 Q201         Br       CH.sub.2 OMe   Gc Q201         Br       SMe            Gc Q201         Br       SO.sub.2 Me    Gc Q201         Br       SO.sub.2 NH.sub.2 G.sub.3 Q201         Br       SO.sub.2 NHMe  Gc Q201         Br       SO.sub.2 NMe.sub.2 G.sub.3 Q201         SMe      COOMe          Gc Q205         SMe      COOMe          Gc Q209         SMe      COOMe          G.sub.3 Q201         SMe      COOEt          Gc Q205         SMe      COOEt          Gc Q209         SMe      COOEt          Gc Q229         SMe      COOEt          G.sub.3 Q246         SMe      COOEt          Gc Q201         SMe      COOPri         Gc Q205         SMe      COOPri         G.sub.3 Q201         SMe      COOCH.sub.2 CH.sub.2 Cl Gc Q201         SMe      COOCH.sub.2 CHCH.sub.2 Gc Q201         SMe      CONHMe         Gc Q201         SMe      CONMe.sub.2    G.sub.1 Q201         SMe      COMe           Gc Q205         SMe      COMe           Gc Q201         SMe      COEt           G.sub.3 Q201         SMe      COPri          Gc Q201         SMe      COPh           G.sub.3 Q201         SMe      CN             Gc Q205         SMe      CN             Gc Q229         SMe      CN             G.sub.3 Q201         SMe      H              Gc Q201         SMe      Me             Gc Q205         SMe      Me             G.sub.3 Q201         SMe      Et             Gc Q205         SMe      Et             Gc Q201         SMe      CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         SMe      Ph             Gc Q205         SMe      Ph             Gc Q209         SMe      Ph             G.sub.3 Q201         SMe      Ph2-Cl         Gc Q201         SMe      Cl             Gc Q205         SMe      Cl             G.sub.3 Q201         SMe      Br             Gc Q201         SMe      NO.sub.2       Gc Q205         SMe      NO.sub.2       Gc Q209         SMe      NO.sub.2       G.sub.3 Q201         SMe      NH.sub.2       Gc Q205         SMe      NH.sub.2       Gc Q201         SMe      NHMe           G.sub.3 Q201         SMe      NMe.sub.2      Gc Q205         SMe      NMe.sub.2      Gc Q201         SMe      NHCOMe         Gc Q205         SMe      NHCOMe         G.sub.3 Q201         SMe      NHSO.sub.2 Me  Gc Q201         SMe      OMe            Gc Q201         SMe      CH.sub.2 OMe   Gc Q201         SMe      SMe            Gc Q201         SMe      SO.sub.2 Me    Gc Q205         SMe      SO.sub.2 Me    G.sub.3 Q201         SMe      SO.sub.2 Ph    Gc Q201         SMe      SO.sub.2 NH.sub.2 Gc Q201         SMe      SO.sub.2 NHMe  G.sub.3 Q201         SMe      SO.sub.2 NMe.sub.2 Gc Q201         SO.sub.2 Me COOMe          Gc Q205         SO.sub.2 Me COOMe          Gc Q209         SO.sub.2 Me COOMe          G.sub.3 Q229         SO.sub.2 Me COOMe          G.sub.3 Q246         SO.sub.2 Me COOMe          G.sub.1 Q201         SO.sub.2 Me COOEt          Gc Q205         SO.sub.2 Me COOEt          Gc Q209         SO.sub.2 Me COOEt          G.sub.3 Q222         SO.sub.2 Me COOEt          Gc Q225         SO.sub.2 Me COOEt          Gc Q201         SO.sub.2 Me COOPri         G.sub.3 Q205         SO.sub.2 Me COOPri         Gc Q201         SO.sub.2 Me COOCH.sub.2 CH.sub.2 Cl Gc Q201         SO.sub.2 Me COOCH.sub.2 CHCH.sub.2 G.sub.3 Q201         SO.sub.2 Me COOCH.sub.2 CCH Gc Q201         SO.sub.2 Me CONHMe         Gc Q201         SO.sub.2 Me CONMe.sub.2    G.sub.2 Q201         SO.sub.2 Me COMe           Gc Q205         SO.sub.2 Me COMe           Gc Q229         SO.sub.2 Me COMe           G.sub.3 Q201         SO.sub.2 Me COEt           Gc Q205         SO.sub.2 Me COEt           Gc Q201         SO.sub.2 Me COPri          G.sub.3 Q201         SO.sub.2 Me COPh           Gc Q201         SO.sub.2 Me CN             Gc Q205         SO.sub.2 Me CN             Gc Q222         SO.sub.2 Me CN             Gc Q229         SO.sub.2 Me CN             Gc Q201         SO.sub.2 Me H              G.sub.2 Q201         SO.sub.2 Me Me             Gc Q205         SO.sub.2 Me Me             Gc Q201         SO.sub.2 Me Et             G.sub.3 Q201         SO.sub.2 Me Pri            Gc Q201         SO.sub.2 Me CHCH.sub.2     Gc Q201         SO.sub.2 Me CHCHMe         G.sub.1 Q201         SO.sub.2 Me CH.sub.2 CH.sub.2 Cl Gc Q205         SO.sub.2 Me CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         SO.sub.2 Me CH.sub.2 Ph    G.sub.3 Q201         SO.sub.2 Me Ph             Gc Q205         SO.sub.2 Me Ph             Gc Q209         SO.sub.2 Me Ph             Gc Q229         SO.sub.2 Me Ph             G.sub.3 Q246         SO.sub.2 Me Ph             G.sub.3 Q201         SO.sub.2 Me Ph2-Cl         Gc Q205         SO.sub.2 Me Ph2-Me         Gc Q201         SO.sub.2 Me Cl             Gc Q205         SO.sub.2 Me Cl             Gc Q229         SO.sub.2 Me Cl             G.sub.3 Q201         SO.sub.2 Me Br             G.sub.3 Q205         SO.sub.2 Me Br             Gc Q201         SO.sub.2 Me NO.sub.2       Gc Q205         SO.sub.2 Me NO.sub.2       Gc Q209         SO.sub.2 Me NO.sub.2       Gc Q229         SO.sub.2 Me NO.sub.2       G.sub.3 Q201         SO.sub.2 Me NH.sub.2       Gc Q205         SO.sub.2 Me NH.sub.2       G.sub.3 Q201         SO.sub.2 Me NHMe           Gc Q201         SO.sub.2 Me NMe.sub.2      Gc Q205         SO.sub.2 Me NMe.sub.2      G.sub.1 Q201         SO.sub.2 Me NHCOMe         Gc Q205         SO.sub.2 Me NHCOMe         Gc Q201         SO.sub.2 Me NHCOEt         G.sub.3 Q201         SO.sub.2 Me NHSO.sub.2 Me  Gc Q201         SO.sub.2 Me OMe            G.sub.1 Q201         SO.sub.2 Me CH.sub.2 OMe   Gc Q205         SO.sub.2 Me CH.sub.2 OMe   Gc Q201         SO.sub.2 Me SO.sub.2 Me    Gc Q205         SO.sub.2 Me SO.sub.2 Me    Gc Q201         SO.sub.2 Me SO.sub.2 Ph    G.sub.3 Q201         SO.sub.2 Me SO.sub.2 OMe   Gc Q201         SO.sub.2 Me SO.sub.2 NH.sub.2 Gc Q201         SO.sub.2 Me SO.sub.2 NHMe  G.sub.3 Q201         SO.sub.2 Me SO.sub.2 NMe.sub.2 Gc Q201         Ph       COOMe          Gc Q205         Ph       COOMe          G.sub.3 Q209         Ph       COOMe          Gc Q201         Ph       COOEt          Gc Q205         Ph       COOEt          Gc Q209         Ph       COOEt          G.sub.3 Q229         Ph       COOEt          Gc Q201         Ph       COOPri         G.sub.3 Q201         Ph       COOCH.sub.2 CH.sub.2 Cl Gc Q201         Ph       COOCH.sub.2 CHCH.sub.2 Gc Q201         Ph       COOCH.sub.2 CCH G.sub.3 Q201         Ph       CONMe.sub.2    Gc Q201         Ph       COMe           Gc Q205         Ph       COMe           Gc Q201         Ph       COEt           G.sub.3 Q201         Ph       CN             Gc Q205         Ph       CN             Gc Q201         Ph       H              G.sub.3 Q201         Ph       Me             Gc Q201         Ph       Et             Gc Q201         Ph       CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         Ph       Ph             Gc Q205         Ph       Ph             Gc Q209         Ph       Ph             G.sub.3 Q201         Ph       Cl             Gc Q201         Ph       Br             G.sub.3 Q201         Ph       NO.sub.2       Gc Q201         Ph       NH.sub.2       Gc Q201         Ph       NHMe           G.sub.3 Q201         Ph       NMe.sub.2      Gc Q201         Ph       NHCOMe         Gc Q201         Ph       NHSO.sub.2 Me  G.sub.1 Q201         Ph       CH.sub.2 OMe   Gc Q201         Ph       SO.sub.2 Me    G.sub.3 Q201         Ph       SO.sub.2 NH.sub.2 Gc Q201         Ph       SO.sub.2 NHMe  Gc Q201         Ph       SO.sub.2 NMe.sub.2 G.sub.3 ______________________________________ ______________________________________ ##STR25## A            B        D              Gn ______________________________________ Q1           H        COOMe          Gb CH.sub.2 - Q1 H        COOMe          Gc CHMe - Q1    H        COOMe          G3 Q2           H        COOMe          Gb Q3           H        COOMe          Gb Q4           H        COOMe          Gb Q5           H        COOMe          Ga CH.sub.2 - Q5 H        COOMe          Gc CHMe - Q5    H        COOMe          G3 Q6           H        COOMe          G3 Q7           H        COOMe          G3 Q8           H        COOMe          G3 Q9           H        COOMe          Gc CH.sub.2 - Q9 H        COOMe          Gc Q10          H        COOMe          Gc Q11          H        COOMe          G3 Q12          H        COOMe          G3 Q13          H        COOMe          G3 Q14          H        COOMe          G1 Q15          H        COOMe          G3 Q16          H        COOMe          Gc Q17          H        COOMe          Gc Q18          H        COOMe          G3 Q19          H        COOMe          Gc Q20          H        COOMe          Gc Q21          H        COOMe          Gc Q22          H        COOMe          G3 Q23          H        COOMe          Gc CH.sub.2 - Q23 H        COOMe          G3 Q24          H        COOMe          Gc Q25          H        COOMe          Gb Q26          H        COOMe          Ga CH.sub.2 - Q26 H        COOMe          G3 CHMe - Q26   H        COOMe          G3 Q27          H        COOMe          G3 Q28          H        COOMe          G3 Q29          H        COOMe          Gc CH.sub.2 - Q29 H        COOMe          G3 Q30          H        COOMe          G3 Q31          H        COOMe          Gc Q32          H        COOMe          Gc CH.sub.2 - Q32 H        COOMe          G3 Q33          H        COOMe          G3 Q34          H        COOMe          G3 Q35          H        COOMe          G3 Q36          H        COOMe          G3 Q37          H        COOMe          Gc Q38          H        COOMe          Gc Q39          H        COOMe          G3 Q40          H        COOMe          Gc Q41          H        COOMe          Gc Q42          H        COOMe          Gc Q43          H        COOMe          G3 Q44          H        COOMe          Gc Q45          H        COOMe          Gc Q46          H        COOMe          Gc Q47          H        COOMe          Gc Q48          H        COOMe          Gc Q49          H        COOMe          G3 Q50          H        COOMe          Gc CH.sub.2 - Q50 H        COOMe          G3 Q51          H        COOMe          Gc Q52          H        COOMe          G3 Q53          H        COOMe          G3 Q54          H        COOMe          Gc Q55          H        COOMe          Gc Q56          H        COOMe          Gc Q57          H        COOMe          G3 Q58          H        COOMe          Gc Q59          H        COOMe          Gc CH.sub.2 - Q59 H        COOMe          G3 Q60          H        COOMe          Gc Q61          H        COOMe          Ga CH.sub.2 - Q61 H        COOMe          Gb CHMe - Q61   H        COOMe          Gc Q62          H        COOMe          Gc Q63          H        COOMe          Gc Q64          H        COOMe          Gb CH.sub.2 - Q64 H        COOMe          G3 CHMe - Q64   H        COOMe          G3 Q65          H        COOMe          G3 Q66          H        COOMe          G3 Q67          H        COOMe          G3 Q68          H        COOMe          G3 Q69          H        COOMe          Gc Q70          H        COOMe          Gc Q71          H        COOMe          Gc Q72          H        COOMe          Gc CH.sub.2 - Q72 H        COOMe          G3 CHMe - Q72   H        COOMe          G3 Q73          H        COOMe          Gc CH.sub.2 - Q73 H        COOMe          G3 Q74          H        COOMe          Gc Q75          H        COOMe          G3 Q76          H        COOMe          G3 Q77          H        COOMe          Gc CH.sub.2 - Q77 H        COOMe          G3 Q78          H        COOMe          Gc Q79          H        COOMe          Gc Q80          H        COOMe          Gc Q81          H        COOMe          G3 Q82          H        COOMe          G3 Q83          H        COOMe          G1 Q84          H        COOMe          G2 Q85          H        COOMe          G3 Q86          H        COOMe          Gc Q87          H        COOMe          G2 Q88          H        COOMe          Gc Q89          H        COOMe          Gc Q90          H        COOMe          Gc Q91          H        COOMe          Gc Q92          H        COOMe          G3 Q93          H        COOMe          Gc Q94          H        COOMe          G3 Q95          H        COOMe          Gc Q96          H        COOMe          G3 Q97          H        COOMe          Gc Q98          H        COOMe          Gc Q99          H        COOMe          Gc Q100         H        COOMe          Gc Q101         H        COOMe          Gc CH.sub. 2 - Q101 H        COOMe          G3 Q102         H        COOMe          G3 Q103         H        COOMe          G3 Q104         H        COOMe          G3 Q105         H        COOMe          Gc Q106         H        COOMe          G3 Q107         H        COOMe          Gc Q108         H        COOMe          G1 Q109         H        COOMe          G3 Q110         H        COOMe          G3 Q111         H        COOMe          G3 Q112         H        COOMe          Gc Q113         H        COOMe          Gc Q114         H        COOMe          Gc Q115         H        COOMe          G2 Q116         H        COOMe          Gc Q117         H        COOMe          Gc Q118         H        COOMe          G3 Q119         H        COOMe          Gc Q120         H        COOMe          Gc Q121         H        COOMe          G2 Q122         H        COOMe          Gc Q123         H        COOMe          Gc Q124         H        COOMe          Gc Q125         H        COOMe          Gc Q126         H        COOMe          Gc Q127         H        COOMe          Gc Q128         H        COOMe          Gc Q129         H        COOMe          Gc Q130         H        COOMe          G2 Q131         H        COOMe          Gc Q132         H        COOMe          Gc Q133         H        COOMe          G3 Q134         H        COOMe          G3 Q135         H        COOMe          Gc Q136         H        COOMe          G3 Q137         H        COOMe          G1 Q138         H        COOMe          Gc CH.sub.2 - Q138 H        COOMe          G3 Q139         H        COOMe          G3 Q140         H        COOMe          G1 Q141         H        COOMe          G3 Q142         H        COOMe          Gc Q143         H        COOMe          Gc CH.sub.2 - Q143 H        COOMe          G3 Q144         H        COOMe          G3 Q145         H        COOMe          Gc Q146         H        COOMe          Gc Q147         H        COOMe          G3 Q148         H        COOMe          G1 Q149         H        COOMe          G3 Q150         H        COOMe          G3 Q151         H        COOMe          G2 Q152         H        COOMe          G1 Q153         H        COOMe          Gc Q154         H        COOMe          Gc Q155         H        COOMe          G3 Q156         H        COOMe          G3 Q157         H        COOMe          Gc Q158         H        COOMe          Ga CH.sub.2 - Q158 H        COOMe          G3 CHMe - Q158  H        COOMe          G3 Q159         H        COOMe          G3 Q160         H        COOMe          Gc Q161         H        COOMe          Gc Q162         H        COOMe          Gc Q163         H        COOMe          G3 Q164         H        COOMe          Gc Q165         H        COOMe          Gc Q166         H        COOMe          Gc Q167         H        COOMe          G3 Q168         H        COOMe          G3 Q169         H        COOMe          Gc CH.sub.2 - Q169 H        COOMe          G3 CHMe - Q169  H        COOMe          G3 Q170         H        COOMe          Gc Q171         H        COOMe          Gc Q172         H        COOMe          Gc Q173         H        COOMe          Gc Q174         H        COOMe          Gc Q175         H        COOMe          Gc Q176         H        COOMe          Gc Q177         H        COOMe          Gc CH.sub.2 - Q177 H        COOMe          G3 CHMe - Q177  H        COOMe          G3 Q178         H        COOMe          G3 Q179         H        COOMe          G3 Q180         H        COOMe          Gc CH.sub.2 - Q180 H        COOMe          G3 Q181         H        COOMe          G1 Q182         H        COOMe          G3 Q183         H        COOMe          G3 Q184         H        COOMe          Gc CH.sub.2 - Q184 H        COOMe          G3 CHMe - Q184  H        COOMe          G3 Q185         H        COOMe          G3 Q186         H        COOMe          G3 Q187         H        COOMe          G3 Q188         H        COOMe          Gb Q189         H        COOMe          Gb Q1           H        COOEt          Gb CH.sub.2 - Q1 H        COOEt          Gc CHMe - Q1    H        COOEt          G3 Q2           H        COOEt          Gb Q3           H        COOEt          Gb Q4           H        COOEt          Gb Q5           H        COOEt          Ga CH.sub.2 - Q5 H        COOEt          Gc CHMe - Q5    H        COOEt          G3 Q6           H        COOEt          G3 Q7           H        COOEt          G3 Q8           H        COOEt          G3 Q9           H        COOEt          Gc CH.sub.2 - Q9 H        COOEt          Gc Q10          H        COOEt          Gc Q11          H        COOEt          G3 Q12          H        COOEt          G3 Q13          H        COOEt          G3 Q14          H        COOEt          G1 Q15          H        COOEt          G3 Q16          H        COOEt          Gc Q17          H        COOEt          Gc Q18          H        COOEt          G3 Q19          H        COOEt          Gc Q20          H        COOEt          Gc Q21          H        COOEt          Gc Q22          H        COOEt          G3 Q23          H        COOEt          Gc CH.sub.2 - Q23 H        COOEt          G3 Q24          H        COOEt          Gc Q25          H        COOEt          Gb Q26          H        COOEt          Ga CH.sub.2 - Q26 H        COOEt          G3 CHMe - Q26   H        COOEt          G3 Q27          H        COOEt          G3 Q28          H        COOEt          G3 Q29          H        COOEt          Gc CH.sub.2 - Q29 H        COOEt          G3 Q30          H        COOEt          G3 Q31          H        COOEt          Gc Q32          H        COOEt          Gc CH.sub.2 - Q32 H        COOEt          G3 Q33          H        COOEt          G3 Q34          H        COOEt          G3 Q35          H        COOEt          G3 Q36          H        COOEt          G3 Q37          H        COOEt          Gc Q38          H        COOEt          Gc Q39          H        COOEt          G3 Q40          H        COOEt          Gc Q41          H        COOEt          Gc Q42          H        COOEt          Gc Q43          H        COOEt          G3 Q44          H        COOEt          Gc Q45          H        COOEt          Gc Q46          H        COOEt          Gc Q47          H        COOEt          Gc Q48          H        COOEt          Gc Q49          H        COOEt          G3 Q50          H        COOEt          Gc CH.sub.2 - Q50 H        COOEt          G3 Q51          H        COOEt          Gc Q52          H        COOEt          G3 Q53          H        COOEt          G3 Q54          H        COOEt          Gc Q55          H        COOEt          Gc Q56          H        COOEt          Gc Q57          H        COOEt          G3 Q58          H        COOEt          Gc Q59          H        COOEt          Gc CH.sub.2 - Q59 H        COOEt          G3 Q60          H        COOEt          Gc Q61          H        COOEt          Ga CH.sub.2 - Q61 H        COOEt          Gb CHMe - Q61   H        COOEt          Gc Q62          H        COOEt          Gc Q63          H        COOEt          Gc Q64          H        COOEt          Gb CH.sub. 2 - Q64 H        COOEt          G3 CHMe - Q64   H        COOEt          G3 Q65          H        COOEt          G3 Q66          H        COOEt          G3 Q67          H        COOEt          G3 Q68          H        COOEt          G3 Q69          H        COOEt          Gc Q70          H        COOEt          Gc Q71          H        COOEt          Gc Q72          H        COOEt          Gc CH.sub.2 - Q72 H        COOEt          G3 CHMe - Q72   H        COOEt          G3 Q73          H        COOEt          Gc CH.sub.2 - Q73 H        COOEt          G3 Q74          H        COOEt          Gc Q75          H        COOEt          G3 Q76          H        COOEt          G3 Q77          H        COOEt          Gc CH.sub.2 - Q77 H        COOEt          G3 Q78          H        COOEt          Gc Q79          H        COOEt          Gc Q80          H        COOEt          Gc Q81          H        COOEt          G3 Q82          H        COOEt          G3 Q83          H        COOEt          G1 Q84          H        COOEt          G2 Q85          H        COOEt          G3 Q86          H        COOEt          Gc Q87          H        COOEt          G2 Q88          H        COOEt          Gc Q89          H        COOEt          Gc Q90          H        COOEt          Gc Q91          H        COOEt          Gc Q92          H        COOEt          G3 Q93          H        COOEt          Gc Q94          H        COOEt          G3 Q95          H        COOEt          Gc Q96          H        COOEt          G3 Q97          H        COOEt          Gc Q98          H        COOEt          Gc Q99          H        COOEt          Gc Q100         H        COOEt          Gc Q101         H        COOEt          Gc CH.sub.2 - Q101 H        COOEt          G3 Q102         H        COOEt          G3 Q103         H        COOEt          G3 Q104         H        COOEt          G3 Q105         H        COOEt          Gc Q106         H        COOEt          G3 Q107         H        COOEt          Gc Q108         H        COOEt          G1 Q109         H        COOEt          G3 Q110         H        COOEt          G3 Q111         H        COOEt          G3 Q112         H        COOEt          Gc Q113         H        COOEt          Gc Q114         H        COOEt          Gc Q115         H        COOEt          G2 Q116         H        COOEt          Gc Q117         H        COOEt          Gc Q118         H        COOEt          G3 Q119         H        COOEt          Gc Q120         H        COOEt          Gc Q121         H        COOEt          G2 Q122         H        COOEt          Gc Q123         H        COOEt          Gc Q124         H        COOEt          Gc Q125         H        COOEt          Gc Q126         H        COOEt          Gc Q127         H        COOEt          Gc Q128         H        COOEt          Gc Q129         H        COOEt          Gc Q130         H        COOEt          G2 Q131         H        COOEt          Gc Q132         H        COOEt          Gc Q133         H        COOEt          G3 Q134         H        COOEt          G3 Q135         H        COOEt          Gc Q136         H        COOEt          G3 Q137         H        COOEt          G1 Q138         H        COOEt          Gc CH.sub.2 - Q138 H        COOEt          G3 Q139         H        COOEt          G3 Q140         H        COOEt          G1 Q141         H        COOEt          G3 Q142         H        COOEt          Gc Q143         H        COOEt          Gc CH.sub.2 - Q143 H        COOEt          G3 Q144         H        COOEt          G3 Q145         H        COOEt          Gc Q146         H        COOEt          Gc Q147         H        COOEt          G3 Q148         H        COOEt          G1 Q149         H        COOEt          G3 Q150         H        COOEt          G3 Q151         H        COOEt          G2 Q152         H        COOEt          G1 Q153         H        COOEt          Gc Q154         H        COOEt          Gc Q155         H        COOEt          G3 Q156         H        COOEt          G3 Q157         H        COOEt          Gc Q158         H        COOEt          Ga CH.sub.2 - Q158 H        COOEt          G3 CHMe - Q158  H        COOEt          G3 Q159         H        COOEt          G3 Q160         H        COOEt          Gc Q161         H        COOEt          Gc Q162         H        COOEt          Gc Q163         H        COOEt          G3 Q164         H        COOEt          Gc Q165         H        COOEt          Gc Q166         H        COOEt          Gc Q167         H        COOEt          G3 Q168         H        COOEt          G3 Q169         H        COOEt          Gc CH.sub.2 - Q169 H        COOEt          G3 CHMe - Q169  H        COOEt          G3 Q170         H        COOEt          Gc Q171         H        COOEt          Gc Q172         H        COOEt          Gc Q173         H        COOEt          Gc Q174         H        COOEt          Gc Q175         H        COOEt          Gc Q176         H        COOEt          Gc Q177         H        COOEt          Gc CH.sub.2 - Q177 H        COOEt          G3 CHMe - Q177  H        COOEt          G3 Q178         H        COOEt          G3 Q179         H        COOEt          G3 Q180         H        COOEt          Gc CH.sub.2 - Q180 H        COOEt          G3 Q181         H        COOEt          G1 Q182         H        COOEt          G3 Q183         H        COOEt          G3 Q184         H        COOEt          Gc CH.sub.2  - Q184 H        COOEt          G3 CHMe - Q184  H        COOEt          G3 Q185         H        COOEt          G3 Q186         H        COOEt          G3 Q187         H        COOEt          G3 Q188         H        COOEt          Gb Q189         H        COOEt          Gb Q5           H        COOPri         G3 Q26          H        COOPri         G3 Q61          H        COOPri         G3 Q158         H        COOPri         G3 Q5           H        COOCH.sub.2 CH.sub.2 Cl G3 Q26          H        COOCH.sub.2 CH.sub.2 Cl G3 Q61          H        COOCH.sub.2 CH.sub.2 Cl G3 Q158         H        COOCH.sub.2 CH.sub.2 Cl G3 Q189         H        COOCH.sub.2 CH.sub.2 Cl G3 Q5           H        COOCH.sub.2 CHCH.sub.2 G3 Q26          H        COOCH.sub.2 CHCH.sub.2 G3 Q61          H        COOCH.sub.2 CHCH.sub.2 G3 Q158         H        COOCH.sub.2 CHCH.sub.2 G3 Q5           H        COOCH.sub.2 CCH G3 Q26          H        COOCH.sub.2 CCH G3 Q61          H        COOCH.sub.2 CCH G3 Q158         H        COOCH.sub.2 CCH G3 Q1           H        COOPri         G3 Q2           H        COOCH.sub.2 CH.sub.2 Cl G3 Q4           H        COOCH.sub.2 CHCH.sub.2 G3 Q7           H        COOCH.sub.2 CCH G3 Q9           H        COOPri         G3 Q10          H        COOCH.sub.2 CH.sub.2 Cl G3 Q19          H        COOPri         G3 Q23          H        COOCH.sub.2 CHCH.sub.2 G3 Q32          H        COOCH.sub.2 CCH G3 Q41          H        COOPri         G3 Q45          H        COOCH.sub.2 CH.sub.2 Cl G3 Q50          H        COOCH.sub.2 CCH G3 Q69          H        COOPri         G3 Q79          H        COOCH.sub.2 CH.sub.2 Cl G3 Q83          H        COOCH.sub.2 CCH G3 Q96          H        COOPri         G3 Q124         H        COOCH.sub.2 CH.sub.2 Cl G3 Q131         H        COOCH.sub.2 CHCH.sub.2 G3 Q132         H        COOCH.sub.2 CCH G3 Q135         H        COOPri         G3 Q138         H        COOPri         G3 Q142         H        COOCH.sub.2 CHCH.sub.2 G3 Q157         H        COOPri         G3 Q159         H        COOCH.sub.2 CH.sub.2 Cl G3 Q177         H        COOCH.sub.2 CHCH.sub.2 G3 Q180         H        COOCH.sub.2 CCH G3 Q184         H        COOPri         G3 Q5           H        COOH           G3 Q26          H        COOH           G3 Q61          H        COOH           G3 Q158         H        COOH           G3 Q5           H        CONHMe         G3 Q26          H        CONHMe         G3 Q61          H        CONHMe         G3 Q158         H        CONHMe         G3 Q5           H        CONMe.sub.2    G3 Q26          H        CONMe.sub.2    G3 Q61          H        CONMe.sub.2    G3 Q158         H        CONMe.sub.2    G3 Q5           H        COMe           G3 Q26          H        COMe           G3 Q61          H        COMe           G3 Q188         H        COMe           Gb Q189         H        COMe           Gb Q158         H        COMe           G3 Q5           H        COEt           G3 Q26          H        COEt           G3 Q61          H        COEt           G3 Q158         H        COEt           G3 Q188         H        COEt           Gb Q189         H        COEt           Gb Q5           H        COPri          G3 Q26          H        COPri          G3 Q61          H        COPri          G3 Q158         H        COPri          G3 Q5           H        COPh           G3 Q26          H        COPh           G3 Q61          H        COPh           G3 Q158         H        COPh           G3 Q1           H        COMe           G3 Q2           H        COEt           G3 Q4           H        COMe           G3 Q7           H        COMe           G3 Q9           H        COEt           G3 Q10          H        COPri          G3 Q19          H        COPh           G3 Q23          H        COMe           G3 Q32          H        COMe           G3 Q41          H        COPri          G3 Q45          H        COPh           G3 Q50          H        COMe           G3 Q69          H        COEt           G3 Q79          H        COPri          G3 Q83          H        COPh           G3 Q96          H        COMe           G3 Q124         H        COEt           G3 Q131         H        COMe           G3 Q132         H        COMe           G3 Q135         H        COEt           G3 Q138         H        COPri          G3 Q142         H        COPh           G3 Q157         H        COMe           G3 Q159         H        COEt           G3 Q177         H        COMe           G3 Q180         H        COMe           G3 Q184         H        COPri          G3 Q4           H        CN             G3 Q5           H        CN             G3 Q7           H        CN             G3 Q9           H        CN             G3 Q23          H        CN             G3 Q26          H        CN             G3 Q32          H        CN             G3 Q61          H        CN             G3 Q96          H        CN             G3 Q142         H        CN             G3 Q158         H        CN             G3 Q5           H        H              G3 Q26          H        H              G3 Q61          H        H              G3 Q158         H        H              G3 Q5           H        Me             G3 Q26          H        Me             G3 Q61          H        Me             G3 Q158         H        Me             G3 Q5           H        Et             G3 Q26          H        Et             G3 Q61          H        Et             G3 Q158         H        Et             G3 Q5           H        Pri            G3 Q26          H        Pri            G3 Q61          H        Pri            G3 Q158         H        Pri            G3 Q5           H        CHCH.sub.2     G3 Q26          H        CHCH.sub.2     G3 Q61          H        CHCHMe         G3 Q158         H        CHCHMe         G3 Q5           H        CH.sub.2 CHCH.sub.2 G3 Q26          H        CH.sub.2 CHCH.sub.2 G3 Q61          H        CH.sub.2 CHCH.sub.2 G3 Q158         H        CH.sub.2 CHCH.sub.2 G3 Q1           H        H              G3 Q2           H        Me             G3 Q4           H        Me             G3 Q7           H        Me             G3 Q9           H        Et             G3 Q10          H        Pri            G3 Q19          H        Me             G3 Q23          H        CH.sub.2 CHCH.sub.2 G3 Q32          H        H              G3 Q41          H        Me             G3 Q45          H        Me             G3 Q50          H        Et             G3 Q69          H        Pri            G3 Q79          H        Me             G3 Q83          H        Et             G3 Q96          H        Me             G3 Q124         H        Et             G3 Q131         H        Me             G3 Q132         H        CH.sub.2 CHCH.sub.2 G3 Q135         H        Et             G3 Q138         H        Pri            G3 Q142         H        H              G3 Q157         H        Me             G3 Q159         H        Me             G3 Q177         H        H              G3 Q180         H        Me             G3 Q184         H        Me             G3 Q5           H        CH.sub.2 Cl    G3 Q26          H        CH.sub.2 Cl    G3 Q61          H        CH.sub.2 Cl    G3 Q158         H        CH.sub.2 Cl    G3 Q5           H        CH.sub.2 CH.sub.2 Cl G3 Q26          H        CH.sub.2 CH.sub.2 Cl G3 Q61          H        CH.sub.2 CH.sub. 2 Cl G3 Q158         H        CH.sub.2 CH.sub.2 Cl G3 Q5           H        CF.sub.3       G3 Q26          H        CF.sub.3       G3 Q61          H        CF.sub.3       G3 Q158         H        CF.sub.3       G3 Q5           H        CFCFCl         G3 Q26          H        CFCFCl         G3 Q61          H        CH.sub.2 Ph    G3 Q158         H        CH.sub.2 Ph    G3 Q5           H        Ph             G3 Q26          H        Ph             G3 Q61          H        Ph             G3 Q158         H        Ph             G3 Q5           H        Ph2-Cl         G3 Q26          H        Ph2-Me         G3 Q61          H        Ph2-Cl         G3 Q158         H        Ph2-Me         G3 Q1           H        Ph             G3 Q2           H        CH.sub.2 Cl    G3 Q4           H        CH.sub.2 CH.sub.2 Cl G3 Q7           H        Ph             G3 Q9           H        CF.sub.3       G3 Q10          H        CF.sub.3       G3 Q19          H        CFCFCl         G3 Q23          H        CH.sub.2 CH.sub.2 Cl G3 Q32          H        Ph             G3 Q41          H        Ph2-Cl         G3 Q45          H        Ph2-Me         G3 Q50          H        CH.sub.2 CH.sub.2 Cl G3 Q69          H        Ph             G3 Q79          H        CF.sub.3       G3 Q83          H        CF.sub.3       G3 Q96          H        Ph             G3 Q124         H        Ph2-Cl         G3 Q131         H        Ph2-Me         G3 Q132         H        CH.sub.2 CH.sub.2 Cl G3 Q135         H        Ph             G3 Q138         H        CF.sub.3       G3 Q142         H        CF.sub.3       G3 Q157         H        CFCFCl         G3 Q159         H        CH.sub.2 Cl    G3 Q177         H        CH.sub.2 CH.sub.2 Cl G3 Q180         H        Ph             G3 Q184         H        Ph2-Cl         G3 Q5           H        Cl             G3 Q26          H        Cl             G3 Q61          H        Cl             G3 Q158         H        Cl             G3 Q5           H        Br             G3 Q26          H        Br             G3 Q61          H        Br             G3 Q158         H        Br             G3 Q5           H        F              G3 Q26          H        F              G3 Q61          H        I              G3 Q158         H        I              G3 Q1           H        Cl             G3 Q2           H        Cl             G3 Q4           H        Cl             G3 Q7           H        Br             G3 Q9           H        F              G3 Q10          H        I              G3 Q19          H        Cl             G3 Q23          H        Cl             G3 Q32          H        Cl             G3 Q41          H        Br             G3 Q45          H        Br             G3 Q50          H        F              G3 Q69          H        Cl             G3 Q79          H        F              G3 Q83          H        Cl             G3 Q96          H        Cl             G3 Q124         H        Cl             G3 Q131         H        Br             G3 Q132         H        Br             G3 Q135         H        F              G3 Q138         H        Br             G3 Q142         H        Cl             G3 Q157         H        Cl             G3 Q159         H        Cl             G3 Q177         H        Br             G3 Q180         H        Br             G3 Q184         H        Cl             G3 Q4           H        NO.sub.2       G3 Q5           H        NO.sub.2       G3 Q7           H        NO.sub.2       G3 Q9           H        NO.sub.2       G3 Q23          H        NO.sub.2       G3 Q26          H        NO.sub.2       G3 Q32          H        NO.sub.2       G3 Q61          H        NO.sub.2       G3 Q96          H        NO.sub.2       G3 Q142         H        NO.sub.2       G3 Q158         H        NO.sub.2       G3 Q5           H        NH.sub.2       G3 Q26          H        NH.sub.2       G3 Q61          H        NH.sub.2       G3 Q158         H        NH.sub.2       G3 Q5           H        NHMe           G3 Q26          H        NHMe           G3 Q61          H        NHMe           G3 Q158         H        NHMe           G3 Q5           H        NMe.sub.2      G3 Q26          H        NMe.sub.2      G3 Q61          H        NMe.sub.2      G3 Q158         H        NMe.sub.2      G3 Q5           H        NMeEt          G3 Q26          H        NMeEt          G3 Q61          H        NMeEt          G3 Q158         H        NMeEt          G3 Q5           H        NHSO.sub.2 Me  G3 Q26          H        NHSO.sub.2 Me  G3 Q61          H        NHSO.sub.2 Me  G3 Q158         H        NHSO.sub.2 Me  G3 Q1           H        NH.sub.2       G3 Q2           H        NH.sub.2       G3 Q4           H        NH.sub.2       G3 Q7           H        NHMe           G3 Q9           H        NHMe           G3 Q10          H        NMe.sub.2      G3 Q19          H        NMeEt          G3 Q23          H        NMe.sub.2      G3 Q32          H        NMeEt          G3 Q41          H        NH.sub.2       G3 Q45          H        NH.sub.2       G3 Q50          H        NHMe           G3 Q69          H        NHMe           G3 Q79          H        NMe.sub.2      G3 Q83          H        NMeEt          G3 Q96          H        NHSO.sub.2 Me  G3 Q124         H        NMe.sub.2      G3 Q131         H        NMeEt          G3 Q132         H        NH.sub.2       G3 Q135         H        NH.sub.2       G3 Q138         H        NHMe           G3 Q142         H        NHMe           G3 Q157         H        NHSO.sub.2 Me  G3 Q159         H        NMe.sub.2      G3 Q177         H        NMeEt          G3 Q180         H        NH.sub.2       G3 Q184         H        NH.sub.2       G3 Q4           H        NHCOMe         G3 Q5           H        NHCOMe         G3 Q7           H        NHCOMe         G3 Q9           H        NHCOMe         G3 Q23          H        NHCOMe         G3 Q26          H        NHCOMe         G3 Q32          H        NHCOMe         G3 Q61          H        NHCOMe         G3 Q96          H        NHCOMe         G3 Q142         H        NHCOMe         G3 Q158         H        NHCOMe         G3 Q5           H        NHCOEt         G3 Q26          H        NHCOEt         G3 Q61          H        NHCOEt         G3 Q158         H        NHCOEt         G3 Q5           H        OMe            G3 Q26          H        OMe            G3 Q61          H        OMe            G3 Q158         H        OMe            G3 Q5           H        OEt            G3 Q26          H        OEt            G3 Q61          H        OEt            G3 Q158         H        OEt            G3 Q5           H        CH.sub.2 OMe   G3 Q26          H        CH.sub.2 OMe   G3 Q61          H        CH.sub.2 OMe   G3 Q158         H        CH.sub.2 OMe   G3 Q5           H        SMe            G3 Q26          H        SMe            G3 Q61          H        SMe            G3 Q158         H        SMe            G3 Q5           H        SO.sub.2 OMe   G3 Q26          H        SO.sub.2 OMe   G3 Q61          H        SO.sub.2 OMe   G3 Q158         H        SO.sub.2 OMe   G3 Q1           H        OMe            G3 Q2           H        OMe            G3 Q4           H        OEt            G3 Q7           H        SO.sub.2 OMe   G3 Q9           H        CH.sub.2 OMe   G3 Q10          H        SMe            G3 Q19          H        SO.sub.2 OMe   G3 Q23          H        OMe            G3 Q32          H        OEt            G3 Q41          H        SO.sub.2 OMe   G3 Q45          H        CH.sub.2 OMe   G3 Q50          H        SMe            G3 Q69          H        SO.sub.2 OMe   G3 Q79          H        OMe            G3 Q83          H        OEt            G3 Q96          H        CH.sub.2 OMe   G3 Q124         H        SMe            G3 Q131         H        OMe            G3 Q132         H        OEt            G3 Q135         H        CH.sub.2 OMe   G3 Q138         H        SMe            G3 Q142         H        SO.sub.2 OMe   G3 Q157         H        OMe            G3 Q159         H        OEt            G3 Q177         H        SO.sub.2 OMe   G3 Q180         H        OMe            G3 Q184         H        OEt            G3 Q4           H        SO.sub.2 Me    G3 Q5           H        SO.sub.2 Me    G3 Q7           H        SO.sub.2 Me    G3 Q9           H        SO.sub.2 Me    G3 Q23          H        SO.sub.2 Me    G3 Q26          H        SO.sub.2 Me    G3 Q32          H        SO.sub.2 Me    G3 Q61          H        SO.sub.2 Me    G3 Q96          H        SO.sub.2 Me    G3 Q142         H        SO.sub.2 Me    G3 Q158         H        SO.sub.2 Me    G3 Q188         H        SO.sub.2 Me    Gb Q189         H        SO.sub.2 Me    Gb Q5           H        SO.sub.2 Ph    G3 Q26          H        SO.sub.2 Ph    G3 Q61          H        SO.sub.2 Ph    G3 Q158         H        SO.sub.2 Ph    G3 Q5           H        SO.sub.2 NH.sub.2 G3 Q26          H        SO.sub.2 NH.sub.2 G3 Q61          H        SO.sub.2 NH.sub.2 G3 Q158         H        SO.sub.2 NH.sub.2 G3 Q5           H        SO.sub.2 NHMe  G3 Q26          H        SO.sub.2 NHMe  G3 Q61          H        SO.sub.2 NHMe  G3 Q158         H        SO.sub.2 NHMe  G3 Q5           H        SO.sub.2 NMe.sub.2 G3 Q26          H        SO.sub.2 NMe.sub.2 G3 Q61          H        SO.sub.2 NMe.sub.2 G3 Q158         H        SO.sub.2 NMe.sub.2 G3 Q188         H        SO.sub.2 NMe.sub.2 Gb Q189         H        SO.sub.2 NMe.sub.2 Gb Q1           H        SO.sub.2 Me    G3 Q2           H        SO.sub.2 Me    G3 Q4           H        SO.sub.2 Ph    G3 Q7           H        SO.sub.2 NH.sub.2 G3 Q9           H        SO.sub.2 NH.sub.2 G3 Q10          H        SO.sub.2 Ph    G3 Q19          H        SO.sub.2 Me    G3 Q23          H        SO.sub.2 Ph    G3 Q32          H        SO.sub. 2 NHMe G3 Q41          H        SO.sub.2 NMe.sub.2 G3 Q45          H        SO.sub.2 Me    G3 Q50          H        SO.sub.2 NH.sub.2 G3 Q69          H        SO.sub.2 Me    G3 Q79          H        SO.sub.2 Ph    G3 Q83          H        SO.sub.2 Me    G3 Q96          H        SO.sub.2 NMe.sub.2 G3 Q124         H        SO.sub.2 NH.sub.2 G3 Q131         H        SO.sub.2 Me    G3 Q132         H        SO.sub.2 Me    G3 Q135         H        SO.sub.2 NHMe  G3 Q138         H        SO.sub.2 NMe.sub.2 G3 Q142         H        SO.sub.2 NH.sub.2 G3 Q157         H        SO.sub.2 Me    G3 Q159         H        SO.sub.2 Me    G3 Q177         H        SO.sub.2 NHMe  G3 Q180         H        SO.sub.2 NHMe.sub.2 G3 Q184         H        SO.sub.2 Me    G3 Q1           Me       COOMe          G3 Q2           Me       COOMe          G3 Q4           Me       COOMe          G3 Q5           Me       COOMe          G3 Q7           Me       COOMe          G3 Q9           Me       COOMe          G3 Q10          Me       COOMe          G3 Q19          Me       COOMe          G3 Q23          Me       COOMe          G3 Q26          Me       COOMe          G3 Q32          Me       COOMe          G3 Q41          Me       COOMe          G3 Q45          Me       COOMe          G3 Q50          Me       COOMe          G3 Q61          Me       COOMe          G3 Q69          Me       COOMe          G3 Q79          Me       COOMe          G3 Q83          Me       COOMe          G3 Q96          Me       COOMe          G3 Q124         Me       COOMe          G3 Q131         Me       COOMe          G3 Q132         Me       COOMe          G3 Q135         Me       COOMe          G3 Q138         Me       COOMe          G3 Q142         Me       COOMe          G3 Q157         Me       COOMe          G3 Q158         Me       COOMe          G3 Q159         Me       COOMe          G3 Q177         Me       COOMe          G3 Q180         Me       COOMe          G3 Q184         Me       COOMe          G3 Q1           Me       COOEt          G3 Q2           Me       COOEt          G3 Q4           Me       COOEt          G3 Q5           Me       COOEt          G3 Q7           Me       COOEt          G3 Q9           Me       COOEt          G3 Q10          Me       COOEt          G3 Q19          Me       COOEt          G3 Q23          Me       COOEt          G3 Q26          Me       COOEt          G3 Q32          Me       COOEt          G3 Q41          Me       COOEt          G3 Q45          Me       COOEt          G3 Q50          Me       COOEt          G3 Q61          H        COOEt          G3 Q69          Me       COOEt          G3 Q79          Me       COOEt          G3 Q83          Me       COOEt          G3 Q96          Me       COOEt          G3 Q124         Me       COOEt          G3 Q131         Me       COOEt          G3 Q132         Me       COOEt          G3 Q135         Me       COOEt          G3 Q138         Me       COOEt          G3 Q142         Me       COOEt          G3 Q157         Me       COOEt          G3 Q158         Me       COOEt          G3 Q159         Me       COOEt          G3 Q177         Me       COOEt          G3 Q180         Me       COOEt          G3 Q184         Me       COOEt          G3 Q158         Me       COOEt          G3 Q5           Me       COOPri         G3 Q26          Me       COOPri         G3 Q61          Me       COOPri         G3 Q158         Me       COOPri         G3 Q5           Me       COOCH.sub.2 CH.sub.2 Cl G3 Q26          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q61          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q158         Me       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Me       COOCH.sub.2 CHCH.sub.2 G3 Q26          Me       COOCH.sub.2 CHCH.sub.2 G3 Q61          Me       COOCH.sub.2 CHCH.sub.2 G3 Q158         Me       COOCH.sub.2 CHCH.sub.2 G3 Q5           Me       COOCH.sub.2 CCH G3 Q26          Me       COOCH.sub.2 CCH G3 Q61          Me       COOCH.sub.2 CCH G3 Q158         Me       COOCH.sub.2 CCH G3 Q5           Me       CONHMe         G3 Q26          Me       CONHMe         G3 Q61          Me       CONHMe         G3 Q158         Me       CONHMe         G3 Q5           Me       CONMe.sub.2    G3 Q26          Me       CONMe.sub.2    G3 Q61          Me       CONMe.sub.2    G3 Q158         Me       CONMe.sub.2    G3 Q1           Me       COOPri         G3 Q2           Me       COOPri         G3 Q4           Me       COOCH.sub.2 CH.sub.2 Cl G3 Q7           Me       COOCH.sub.2 CHCH.sub.2 G3 Q9           Me       COOCH.sub.2 CCH G3 Q10          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q19          Me       COOPri         G3 Q23          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q32          Me       CONMe.sub.2    G3 Q41          Me       COOPri         G3 Q45          Me       CONHMe         G3 Q50          Me       CONMe.sub.2    G3 Q69          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q79          Me       COOCH.sub.2 CHCH.sub.2 G3 Q83          Me       COOPri         G3 Q96          Me       COOCH.sub.2 CH.sub.2 Cl G3 Q124         Me       COOPri         G3 Q131         Me       COOCH.sub.2 CH.sub.2 Cl G3 Q132         Me       CONHMe         G3 Q135         Me       CONMe.sub.2    G3 Q138         Me       COOCH.sub.2 CCH G3 Q142         Me       COOPri         G3 Q157         Me       COOPri         G3 Q159         Me       COOCH.sub.2 CHCH.sub.2 G3 Q177         Me       COOCH.sub.2 CCH G3 Q180         Me       COOPri         G3 Q184         Me       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Me       COMe           G3 Q26          Me       COMe           G3 Q61          Me       COMe           G3 Q158         Me       COMe           G3 Q5           Me       COEt           G3 Q26          Me       COEt           G3 Q61          Me       COEt           G3 Q158         Me       COEt           G3 Q5           Me       COPri          G3 Q26          Me       COPri          G3 Q61          Me       COPri          G3 Q158         Me       COPr i         G3 Q5           Me       CN             G3 Q26          Me       CN             G3 Q61          Me       CN             G3 Q158         Me       CN             G3 Q5           Me       H              G3 Q26          Me       H              G3 Q61          Me       H              G3 Q158         Me       H              G3 Q5           Me       Me             G3 Q26          Me       Me             G3 Q61          Me       Me             G3 Q158         Me       Me             G3 Q5           Me       Et             G3 Q26          Me       Et             G3 Q61          Me       Et             G3 Q158         Me       Et             G3 Q5           Me       Pri            G3 Q26          Me       Pri            G3 Q61          Me       CHCH.sub.2     G3 Q158         Me       CHCH.sub.2     G3 Q5           Me       CHCHMe         G3 Q26          Me       CH.sub.2 CHCH.sub.2 G3 Q61          Me       CHCHMe         G3 Q158         Me       CH.sub.2 CHCH.sub.2 G3 Q1           Me       COMe           G3 Q2           Me       COEt           G3 Q4           Me       CHCHMe         G3 Q7           Me       CH.sub.2 CHCH.sub.2 G3 Q9           Me       CN             G3 Q10          Me       H              G3 Q19          Me       Me             G3 Q23          Me       COMe           G3 Q32          Me       COEt           G3 Q41          Me       H              G3 Q45          Me       Me             G3 Q50          Me       COPri          G3 Q69          Me       CN             G3 Q79          Me       Et             G3 Q83          Me       Pri            G3 Q96          Me       COMe           G3 Q124         Me       COEt           G3 Q131         Me       CH.sub.2 CHCH.sub.2 G3 Q132         Me       Me             G3 Q135         Me       COPr-i         G3 Q138         Me       CN             G3 Q142         Me       Et             G3 Q157         Me       CH.sub.2 CHCH.sub.2 G3 Q159         Me       COMe           G3 Q177         Me       COEt           G3 Q180         Me       CHCHMe         G3 Q184         Me       COMe           G3 Q5           Me       CH.sub.2 Cl    G3 Q26          Me       CH.sub.2 Cl    G3 Q5           Me       CH.sub.2 CH.sub.2 Cl G3 Q26          Me       CH.sub.2 CH.sub.2 Cl G3 Q61          Me       CH.sub.2 CH.sub.2 Cl G3 Q158         Me       CH.sub.2 CH.sub.2 Cl G3 Q5           Me       CF.sub.3       G3 Q26          Me       CF.sub.3       G3 Q61          Me       CF.sub.3       G3 Q158         Me       CF.sub.3       G3 Q5           Me       CFCFCl         G3 Q26          Me       CFCFCl         G3 Q61          Me       CH.sub.2 Ph    G3 Q158         Me       CH.sub.2 Ph    G3 Q5           Me       Ph             G3 Q26          Me       Ph             G3 Q61          Me       Ph             G3 Q158         Me       Ph             G3 Q5           Me       Ph2-Cl         G3 Q26          Me       Ph2-Cl         G3 Q61          Me       Ph2-Me         G3 Q158         Me       Ph2-Me         G3 Q5           Me       Cl             G3 Q26          Me       Cl             G3 Q61          Me       Cl             G3 Q158         Me       Cl             G3 Q5           Me       Br             G3 Q26          Me       Br             G3 Q61          Me       Br             G3 Q158         Me       Br             G3 Q5           Me       F              G3 Q26          Me       F              G3 Q61          Me       I              G3 Q158         Me       I              G3 Q1           Me       Ph             G3 Q2           Me       Cl             G3 Q4           Me       CH.sub.2 CH.sub.2 Cl G3 Q7           Me       Ph             G3 Q9           Me       Ph             G3 Q10          Me       Cl             G3 Q19          Me       Cl             G3 Q23          Me       Br             G3 Q32          Me       CH.sub.2 Cl    G3 Q41          Me       CH.sub.2 CH.sub.2 Cl G3 Q45          Me       CF.sub.3       G3 Q50          Me       Cl             G3 Q69          Me       Cl             G3 Q79          Me       Br             G3 Q83          Me       Ph             G3 Q96          Me       CF.sub.3       G3 Q124         Me       CF.sub.3       G3 Q131         Me       CH.sub.2 CH.sub.2 Cl G3 Q132         Me       Ph             G3 Q135         Me       Br             G3 Q138         Me       Ph             G3 Q142         Me       Ph             G3 Q157         Me       Cl             G3 Q159         Me       Br             G3 Q177         Me       CF.sub.3       G3 Q180         Me       CH.sub.2 CH.sub.2 Cl G3 Q184         Me       Ph             G3 Q5           Me       NO.sub.2       G3 Q26          Me       NO.sub.2       G3 Q61          Me       NO.sub.2       G3 Q158         Me       NO.sub.2       G3 Q5           Me       NH.sub.2       G3 Q26          Me       NH.sub.2       G3 Q61          Me       NH.sub.2       G3 Q158         Me       NH.sub.2       G3 Q5           Me       NHMe           G3 Q26          Me       NHMe           G3 Q61          Me       NHMe           G3 Q158         Me       NHMe           G3 Q5           Me       NMe.sub.2      G3 Q26          Me       NMe.sub.2      G3 Q61          Me       NMe.sub.2      G3 Q158         Me       NMe.sub.2      G3 Q5           Me       NMeEt          G3 Q26          Me       NMeEt          G3 Q5           Me       NHCOMe         G3 Q26          Me       NHCOMe         G3 Q61          Me       NHCOMe         G3 Q158         Me       NHCOMe         G3 Q5           Me       NHCOEt         G3 Q26          Me       NHCOEt         G3 Q61          Me       NHSO.sub.2 Me  G3 Q158         Me       NHSO.sub.2 Me  G3 Q5           Me       OMe            G3 Q26          Me       OMe            G3 Q61          Me       OMe            G3 Q158         Me       OMe            G3 Q5           Me       OEt            G3 Q26          Me       OEt            G3 Q61          Me       CH.sub.2 OMe   G3 Q158         Me       CH.sub.2 OMe   G3 Q1           Me       NO.sub.2       G3 Q2           Me       NHCOMe         G3 Q4           Me       NHCOEt         G3 Q7           Me       NHMe           G3 Q9           Me       NO.sub.2       G3 Q10          Me       NH.sub.2       G3 Q19          Me       NHCOMe         G3 Q23          Me       OMe            G3 Q32          Me       NHCOMe         G3 Q41          Me       NHCOEt         G3 Q45          Me       CH.sub.2 OMe   G3 Q50          Me       OMe            G3 Q69          Me       OEt            G3 Q79          Me       NO.sub.2       G3 Q83          Me       NH.sub.2       G3 Q96          Me       NMe.sub.2      G3 Q124         Me       NMeEt          G3 Q131         Me       NHCOMe         G3 Q132         Me       NHCOEt         G3 Q135         Me       NO.sub.2       G3 Q138         Me       OMe            G3 Q142         Me       OEt            G3 Q157         Me       NO.sub.2       G3 Q159         Me       NH.sub.2       G3 Q177         Me       OMe            G3 Q180         Me       NHCOMe         G3 Q184         Me       NO.sub.2       G3 Q26          Me       SMe            G3 Q61          Me       SMe            G3 Q5           Me       SO.sub.2 Me    G3 Q26          Me       SO.sub.2 Me    G3 Q61          Me       SO.sub.2 Me    G3 Q158         Me       SO.sub.2 Me    G3 Q5           Me       SO.sub.2 Ph    G3 Q26          Me       SO.sub.2 Ph    G3 Q61          Me       SO.sub.2 Ph    G3 Q158         Me       SO.sub.2 Ph    G3 Q5           Me       SO.sub.2 OMe   G3 Q26          Me       SO.sub.2 OMe   G3 Q61          Me       SO.sub.2 NH.sub.2 G3 Q158         Me       SO.sub.2 NH.sub.2 G3 Q5           Me       SO.sub.2 NMe   G3 Q26          Me       SO.sub.2 NMe   G3 Q61          Me       SO.sub.2 NMe   G3 Q158         Me       SO.sub.2 NMe   G3 Q5           Me       SO.sub.2 NHMe.sub.2 G3 Q26          Me       SO.sub.2 NHMe.sub.2 G3 Q61          Me       SO.sub.2 NHMe.sub.2 G3 Q158         Me       SO.sub.2 NHMe.sub.2 G3 Q1           Me       SO.sub.2 Ph    G3 Q2           Me       SO.sub.2 OMe   G3 Q4           Me       SO.sub.2 NHMe  G3 Q7           Me       SO.sub.2 NMe.sub.2 G3 Q9           Me       SO.sub.2 Me    G3 Q10          Me       SO.sub.2 Me    G3 Q19          Me       SMe            G3 Q23          Me       SO.sub.2 Me    G3 Q32          Me       SO.sub.2 OMe   G3 Q41          Me       SO.sub.2 NMe.sub.2 G3 Q45          Me       SO.sub.2 NHMe  G3 Q50          Me       SO.sub.2 NMe.sub.2 G3 Q69          Me       SO.sub.2 Me    G3 Q79          Me       SO.sub.2 Me    G3 Q83          Me       SO.sub.2 Ph    G3 Q96          Me       SO.sub.2 OMe   G3 Q124         Me       SO.sub.2 NMe.sub.2 G3 Q131         Me       SO.sub.2 NHMe  G3 Q132         Me       SO.sub.2 NMe.sub.2 G3 Q135         Me       SO.sub.2 Ph    G3 Q138         Me       SO.sub.2 Ph    G3 Q142         Me       SO.sub.2 Me    G3 Q157         Me       SO.sub.2 Me    G3 Q159         Me       SO.sub.2 NHMe  G3 Q177         Me       SO.sub.2 NMe.sub.2 G3 Q180         Me       SO.sub.2 NMe.sub.2 G3 Q184         Me       SO.sub.2 Me.sub.2 G3 Q5           Et       COOMe          G3 Q26          Et       COOMe          G3 Q61          Et       COOMe          G3 Q142         Et       COOMe          G3 Q158         Et       COOMe          G3 Q159         Et       COOMe          G3 Q4           Et       COOEt          G3 Q5           Et       COOEt          G3 Q9           Et       COOEt          G3 Q26          Et       COOEt          G3 Q32          Et       COOEt          G3 Q61          Et       COOEt          G3 Q69          Et       COOEt          G3 Q96          Et       COOEt          G3 Q158         Et       COOEt          G3 Q61          Et       COOPri         G3 Q158         Et       COOPri         G3 Q5           Et       COOCH.sub.2 CH.sub.2 Cl G3 Q26          Et       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Et       COOCH.sub.2 CHCH.sub.2 G3 Q158         Et       COOCH.sub.2 CHCH.sub.2 G3 Q5           Et       COOCH.sub.2 CCH G3 Q26          Et       COOCH.sub.2 CCH G3 Q5           Et       CONHMe         G3 Q26          Et       CONMe.sub.2    G3 Q1           Et       COOPri         G3 Q4           Et       COOCH.sub.2 CH.sub.2 Cl G3 Q69          Et       COOCH.sub.2 CH.sub.2 Cl G3 Q79          Et       COOCH.sub.2 CHCH.sub.2 G3 Q83          Et       COOPri         G3 Q96          Et       COOCH.sub.2 CH.sub.2 Cl G3 Q131         Et       COOCH.sub.2 CH.sub.2 Cl G3 Q157         Et       COOPri         G3 Q159         Et       COOCH.sub.2 CHCH.sub.2 G3 Q184         Et       COOCH.sub.2 CH.sub.2 Cl G3 Q5           Et       COMe           G3 Q26          Et       COMe           G3 Q158         Et       COEt           G3 Q5           Et       COPri          G3 Q26          Et       CN             G3 Q61          Et       H              G3 Q26          Et       Me             G3 Q158         Et       Et             G3 Q5           Et       Pri            G3 Q1           Et       COMe           G3 Q2           Et       COEt           G3 Q9           Et       CN             G3 Q23          Et       COMe           G3 Q96          Et       COMe           G3 Q124         Et       COEt           G3 Q135         Et       COPri          G3 Q138         Et       CN             G3 Q5           Et       CH.sub.2 CH.sub.2 Cl G3 Q26          Et       CH.sub.2 CH.sub.2 Cl G3 Q158         Et       CF.sub.3       G3 Q5           Et       Ph             G3 Q26          Et       Ph             G3 Q158         Et       Ph2-Me         G3 Q26          Et       Cl             G3 Q61          Et       Cl             G3 Q5           Et       Br             G3 Q1           Et       Ph             G3 Q2           Et       Cl             G3 Q9           Et       Ph             G3 Q5           Et       NO.sub.2       G3 Q5           Et       NH.sub.2       G3 Q5           Et       NHMe           G3 Q26          Et       NMe.sub.2      G3 Q61          Et       NHCOMe         G3 Q158         Et       NHSO.sub.2 Me  G3 Q2           Et       NHCOMe         G3 Q23          Et       OMe            G3 Q32          Et       NHCOMe         G3 Q96          Et       NMe.sub.2      G3 Q26          Et       SO.sub.2 Me    G3 Q61          Et       SO.sub.2 Me    G3 Q5           Et       SO.sub.2 Ph    G3 Q26          Et       SO.sub.2 OMe   G3 Q61          Et       SO.sub.2 NH.sub.2 G3 Q5           Et       SO.sub.2 NHMe  G3 Q26          Et       SO.sub.2 NMe.sub.2 G3 Q4           Et       SO.sub.2 NHMe  G3 Q7           Et       SO.sub.2 NMe.sub.2 G3 Q9           Et       SO.sub.2 Me    G3 Q142         Et       SO.sub.2 Me    G3 Q159         Et       SO.sub.2 NMe.sub.2 G3 Q5           Cl       COOMe          G3 Q26          Cl       COOMe          G3 Q61          Cl       COOMe          G3 Q5           Cl       COOEt          G3 Q26          Cl       COOEt          G3 Q61          Cl       COOEt          G3 Q96          Cl       COOEt          G3 Q158         Cl       COOEt          G3 Q61          Cl       COOPri         G3 Q5           Cl       COMe           G3 Q158         Cl       COEt           G3 Q5           Cl       COPri          G3 Q26          Cl       CN             G3 Q61          Cl       H              G3 Q26          Cl       Me             G3 Q158         Cl       Et             G3 Q5           Cl       Pri            G3 Q1           Cl       COMe           G3 Q26          Cl       CH.sub.2 CH.sub.2 Cl G3 Q158         Cl       CF.sub.3       G3 Q5           Cl       Ph             G3 Q26          Cl       Cl             G3 Q5           Cl       Br             G3 Q2           Cl       Cl             G3 Q9           Cl       Ph             G3 Q5           Cl       NO.sub.2       G3 Q5           Cl       NH.sub.2       G3 Q5           Cl       NHMe           G3 Q26          Cl       NMe.sub.2      G3 Q61          Cl       NHCOMe         G3 Q158         Cl       NHSO.sub.2 Me  G3 Q2           Cl       NHCOMe         G3 Q26          Cl       SO.sub.2 Me    G3 Q61          Cl       SO.sub.2 Me    G3 Q5           Cl       SO.sub.2 Ph    G3 Q61          Cl       SO.sub.2 NH.sub.2 G3 Q5           Cl       SO.sub.2 NHMe  G3 Q26          Cl       SO.sub.2 NMe.sub.2 G3 Q5           Br       COOMe          G3 Q26          Br       COOMe          G3 Q61          Br       COOMe          G3 Q5           Br       COOEt          G3 Q26          Br       COOEt          G3 Q61          Br       COOEt          G3 Q61          Br       COOPri         G3 Q5           Br       COMe           G3 Q158         Br       COEt           G3 Q26          Br       CN             G3 Q26          Br       Me             G3 Q158         Br       Et             G3 Q26          Br       CH.sub.2 CH.sub.2 Cl G3 Q158         Br       CF.sub.3       G3 Q5           Br       Ph             G3 Q26          Br       Cl             G3 Q5           Br       Br             G3 Q5           Br       NO.sub.2       G3 Q5           Br       NH.sub.2       G3 Q26          Br       NMe.sub.2      G3 Q61          Br       NHCOMe         G3 Q61          Br       SO.sub.2 Me    G3 Q5           Br       SO.sub.2 Ph    G3 Q61          Br       SO.sub.2 NH.sub.2 G3 Q26          Br       SO.sub.2 NMe.sub.2 G3 Q5           SMe      COOMe          G3 Q26          SMe      COOMe          G3 Q61          SMe      COOMe          G3 Q5           SMe      COOEt          G3 Q26          SMe      COOEt          G3 Q61          SMe      COOEt          G3 Q61          SMe      COOPri         G3 Q5           SMe      COMe           G3 Q158         SMe      COEt           G3 Q26          SMe      CN             G3 Q26          SMe      Me             G3 Q158         SMe      Et             G3 Q26          SMe      CH.sub.2 CH.sub.2 Cl G3 Q158         SMe      CF.sub.3       G3 Q5           SMe      Ph             G3 Q26          SMe      Cl             G3 Q5           SMe      Br             G3 Q5           SMe      NO.sub.2       G3 Q5           SMe      NH.sub.2       G3 Q26          SMe      NMe.sub.2      G3 Q61          SMe      NHCOMe         G3 Q61          SMe      SO.sub.2 Me    G3 Q5           SMe      SO.sub.2 Ph    G3 Q61          SMe      SO.sub.2 NH.sub.2 G3 Q26          SMe      SO.sub.2 NMe.sub.2 G3 Q5           SO.sub. 2 Me COOMe          G3 Q26          SO.sub.2 Me COOMe          G3 Q61          SO.sub.2 Me COOMe          G3 Q5           SO.sub.2 Me COOEt          G3 Q26          SO.sub.2 Me COOEt          G3 Q61          SO.sub.2 Me COOEt          G3 Q96          SO.sub.2 Me COOEt          G3 Q158         SO.sub.2 Me COOEt          G3 Q61          SO.sub.2 Me COOPri         G3 Q5           SO.sub.2 Me COMe           G3 Q158         SO.sub.2 Me COEt           G3 Q5           SO.sub.2 Me COPri          G3 Q26          SO.sub.2 Me CN             G3 Q61          SO.sub.2 Me H              G3 Q26          SO.sub.2 Me Me             G3 Q158         SO.sub.2 Me Et             G3 Q5           SO.sub.2 Me Pri            G3 Q1           SO.sub.2 Me COMe           G3 Q26          SO.sub.2 Me CH.sub.2 CH.sub.2 Cl G3 Q158         SO.sub.2 Me CF.sub.3       G3 Q5           SO.sub.2 Me Ph             G3 Q26          SO.sub.2 Me Cl             G3 Q5           SO.sub.2 Me Br             G3 Q2           SO.sub.2 Me Cl             G3 Q9           SO.sub.2 Me Ph             G3 Q5           SO.sub.2 Me NO.sub.2       G3 Q5           SO.sub.2 Me NH.sub.2       G3 Q5           SO.sub.2 Me NHMe           G3 Q26          SO.sub.2 Me NMe.sub.2      G3 Q61          SO.sub.2 Me NHCOMe         G3 Q158         SO.sub.2 Me NHSO.sub.2 Me  G3 Q2           SO.sub.2 Me NHCOMe         G3 Q26          SO.sub.2 Me SO.sub.2 Me    G3 Q61          SO.sub.2 Me SO.sub.2 Me    G3 Q5           SO.sub.2 Me SO.sub.2 Ph    G3 Q61          SO.sub.2 Me SO.sub.2 NH.sub.2 G3 Q5           SO.sub.2 Me SO.sub.2 NHMe  G3 Q26          SO.sub.2 Me SO.sub.2 NMe.sub.2 G3 Q5           Ph       COOMe          G3 Q26          Ph       COOMe          G3 Q61          Ph       COOMe          G3 Q5           Ph       COOEt          G3 Q26          Ph       COOEt          G3 Q61          Ph       COOEt          G3 Q61          Ph       COOPri         G3 Q5           Ph       COMe           G3 Q158         Ph       COEt           G3 Q26          Ph       CN             G3 Q26          Ph       Me             G3 Q158         Ph       Et             G3 Q26          Ph       CH.sub.2 CH.sub.2 Cl G3 Q158         Ph       CF.sub.3       G3 Q5           Ph       Ph             G3 Q26          Ph       Cl             G3 Q5           Ph       Br             G3 Q5           Ph       NO.sub.2       G3 Q5           Ph       NH.sub.2       G3 Q26          Ph       NMe.sub.2      G3 Q61          Ph       NHCOMe         G3 Q61          Ph       SO.sub.2 Me    G3 Q5           Ph       SO.sub.2 Ph    G3 Q61          Ph       SO.sub.2 NH.sub.2 G3 Q26          Ph       SO.sub.2 NMe.sub.2 G3 Q201         H        COOMe          Ga CH.sub.2 - Q201 H        COOMe          Gb CHMe - Q201  H        COOMe          Gb Q202         H        COOMe          Gb CH.sub.2 - Q202 H        COOMe          Gb Q203         H        COOMe          Gb Q204         H        COOMe          Gb Q205         H        COOMe          Gb CH.sub.2 - Q205 H        COOMe          Gc Q206         H        COOMe          G.sub.3 Q207         H        COOMe          Gc Q208         H        COOMe          G.sub.3 Q209         H        COOMe          Gc CH.sub.2 - Q209 H        COOMe          Gc Q210         H        COOMe          Gc CH.sub.2 - Q210 H        COOMe          G.sub.3 Q211         H        COOMe          G.sub.3 Q212         H        COOMe          Gc Q213         H        COOMe          Gc Q214         H        COOMe          Gc Q215         H        COOMe          G.sub.1 Q216         H        COOMe          Gc Q217         H        COOMe          Gc Q218         H        COOMe          G.sub.3 Q219         H        COOMe          Gc Q220         H        COOMe          Gc Q221         H        COOMe          G.sub.2 Q222         H        COOMe          Gb CH.sub.2 - Q222 H        COOMe          Gc Q223         H        COOMe          Gc Q224         H        COOMe          G.sub.3 Q225         H        COOMe          Gb CH.sub.2 - Q225 H        COOMe          Gc Q226         H        COOMe          G.sub.3 Q227         H        COOMe          Gc Q228         H        COOMe          Gc Q229         H        COOMe          Gb CH.sub.2 - Q229 H        COOMe          Gc Q230         H        COOMe          Gc Q231         H        COOMe          Gc Q232         H        COOMe          G.sub.3 Q233         H        COOMe          Gc Q234         H        COOMe          Gc Q235         H        COOMe          Gc Q236         H        COOMe          G.sub.3 Q237         H        COOMe          Gc Q238         H        COOMe          Gc Q239         H        COOMe          G.sub.2 Q240         H        COOMe          Gc Q241         H        COOMe          Gc Q242         H        COOMe          Gc Q243         H        COOMe          G.sub.1 Q244         H        COOMe          Gc Q245         H        COOMe          Gc Q246         H        COOMe          Gb CH.sub.2 - Q246 H        COOMe          Gc Q247         H        COOMe          G.sub.3 Q248         H        COOMe          Gc Q249         H        COOMe          Gc Q250         H        COOMe          Gc CH.sub.2 - Q250 H        COOMe          G.sub.3 Q251         H        COOMe          Gc Q252         H        COOMe          Gc Q253         H        COOMe          Gc Q254         H        COOMe          G.sub.1 Q255         H        COOMe          Gc Q256         H        COOMe          Gc Q257         H        COOMe          G.sub.3 Q258         H        COOMe          Gc Q259         H        COOMe          Gc CH.sub.2 - Q259 H        COOMe          Gc Q260         H        COOMe          Gc CH.sub.2 - Q260 H        COOMe          Gc Q261         H        COOMe          G.sub.1 Q262         H        COOMe          Gc Q263         H        COOMe          Gc Q264         H        COOMe          G.sub.2 Q201         H        COOEt          Ga CH.sub.2 - Q201 H        COOEt          Gb CHMe - Q201  H        COOEt          Gb Q202         H        COOEt          Gb CH.sub.2 - Q202 H        COOEt          Gb Q203         H        COOEt          Gb Q204         H        COOEt          Gb Q205         H        COOEt          Gb CH.sub.2 - Q205 H        COOEt          Gc Q206         H        COOEt          G.sub.3 Q207         H        COOEt          Gc Q208         H        COOEt          G.sub.3 Q209         H        COOEt          Gc CH.sub.2 - Q209 H        COOEt          Gc Q210         H        COOEt          Gc CH.sub.2 - 210 H        COOEt          G.sub.3 Q211         H        COOEt          Gc Q212         H        COOEt          Gc Q213         H        COOEt          Gc Q214         H        COOEt          G.sub.1 Q215         H        COOEt          Gc Q216         H        COOEt          Gc Q217         H        COOEt          G.sub.2 Q218         H        COOEt          Gc Q219         H        COOEt          Gc Q220         H        COOEt          G.sub.3 Q221         H        COOEt          Gc Q222         H        COOEt          Gb CH.sub.2 - Q222 H        COOEt          Gc Q223         H        COOEt          Gc Q224         H        COOEt          Gc Q225         H        COOEt          Gb CH.sub.2 - Q225 H        COOEt          Gc Q226         H        COOEt          G.sub.3 Q227         H        COOEt          Gc Q228         H        COOEt          Gc Q229         H        COOEt          Gb CH.sub.2 - Q229 H        COOEt          Gc Q230         H        COOEt          Gc Q231         H        COOEt          Gc Q232         H        COOEt          G.sub.3 Q233         H        COOEt          Gc Q234         H        COOEt          Gc CH.sub.2 - Q234 H        COOEt          Gc Q235         H        COOEt          Gc Q236         H        COOEt          G.sub.3 Q237         H        COOEt          Gc Q238         H        COOEt          Gc Q239         H        COOEt          Gc Q240         H        COOEt          G.sub.1 Q241         H        COOEt          Gc Q242         H        COOEt          Gc Q243         H        COOEt          Gc Q244         H        COOEt          G.sub.2 Q245         H        COOEt          Gc Q246         H        COOEt          Gb CH.sub.2 - Q246 H        COOEt          Gc Q247         H        COOEt          Gc Q248         H        COOEt          Gc Q249         H        COOEt          G.sub.3 Q250         H        COOEt          Gc CH.sub.2 - Q250 H        COOEt          Gc Q251         H        COOEt          Gc Q252         H        COOEt          G.sub.3 Q253         H        COOEt          Gc Q254         H        COOEt          Gc Q255         H        COOEt          Gc Q256         H        COOEt          Gc Q257         H        COOEt          Gc Q258         H        COOEt          G.sub.1 Q259         H        COOEt          Gc CH.sub.2 - Q259 H        COOEt          Gc Q260         H        COOEt          Gc CH.sub.2 - Q260 H        COOEt          Gc Q261         H        COOEt          G.sub.3 Q262         H        COOEt          Gc Q263         H        COOEt          Gc Q264         H        COOEt          G.sub.3 Q201         H        COOH           Gc Q202         H        COOH           Gc Q222         H        COOH           Gc Q225         H        COOH           G.sub.3 Q229         H        COOH           Gc Q246         H        COOH           G.sub.3 Q201         H        COOPri         Gc Q202         H        COOPri         G.sub.3 Q205         H        COOPri         Gc Q209         H        COOPri         Gc Q222         H        COOPri         Gc Q225         H        COOPri         Gc Q229         H        COOPri         G.sub.3 Q246         H        COOPri         Gc Q201         H        COOCH.sub.2 CH.sub.2 Cl Gc Q202         H        COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q205         H        COOCH.sub.2 CH.sub.2 Cl Gc Q209         H        COOCH.sub.2 CH.sub.2 Cl Gc Q222         H        COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q225         H        COOCH.sub.2 CH.sub.2 Cl Gc Q229         H        COOCH.sub.2 CH.sub.2 Cl Gc Q246         H        COOCH.sub.2 CH.sub.2 Cl G.sub.1 Q201         H        COOCH.sub.2 CHCH.sub.2 Gc Q202         H        COOCH.sub.2 CHCH.sub.2 Gc Q205         H        COOCH.sub.2 CHCH.sub.2 G.sub.3 Q209         H        COOCH.sub.2 CHCH.sub.2 Gc Q222         H        COOCH.sub.2 CHCH.sub.2 Gc Q225         H        COOCH.sub.2 CHCH.sub.2 Gc Q229         H        COOCH.sub.2 CHCH.sub.2 G.sub.3 Q246         H        COOCH.sub.2 CHCH.sub.2 Gc Q201         H        COOCH.sub.2 CCH Gc Q202         H        COOCH.sub.2 CCH G.sub.3 Q205         H        COOCH.sub.2 CCH Gc Q209         H        COOCH.sub.2 CCH Gc Q222         H        COOCH.sub. 2 CCH Gc Q225         H        COOCH.sub.2 CCH G.sub.3 Q229         H        COOCH.sub.2 CCH Gc Q246         H        COOCH.sub.2 CCH G.sub.3 Q201         H        CONHMe         Gc Q202         H        CONHMe         G.sub.3 Q205         H        CONHMe         Gc Q209         H        CONHMe         Gc Q222         H        CONHMe         G.sub.3 Q225         H        CONHMe         Gc Q229         H        CONHMe         Gc Q246         H        CONHMe         G.sub.3 Q201         H        CONMe.sub.2    Gc Q202         H        CONMe.sub.2    G.sub.3 Q205         H        CONMe.sub.2    Gc Q209         H        CONMe.sub.2    Gc Q222         H        CONMe.sub.2    Gc Q225         H        COMe           Gc Q229         H        COMe           Gc Q230         H        COMe           G.sub.2 Q231         H        COMe           G.sub.3 Q237         H        COMe           Gc Q246         H        COMe           Gc Q247         H        COMe           G.sub.3 Q250         H        COMe           Gc Q259         H        COMe           Gc Q260         H        COMe           Gc Q263         H        COMe           G.sub.3 Q201         H        COEt           Gc Q202         H        COEt           G.sub.3 Q205         H        COEt           Gc Q209         H        COEt           Gc Q222         H        COEt           Gc Q225         H        COEt           G.sub.3 Q229         H        COEt           Gc Q246         H        COEt           G.sub.3 Q201         H        COPri          Gc Q202         H        COPri          G.sub.3 Q205         H        COPri          Gc Q209         H        COPri          Gc Q222         H        COPri          Gc Q225         H        COPri          G.sub.3 Q229         H        COPri          Gc Q246         H        COPri          Gc Q201         H        COPh           Gc Q202         H        COPh           G.sub.3 Q205         H        COPh           Gc Q209         H        COPh           Gc Q222         H        COPh           G.sub.3 Q225         H        COPh           Gc Q229         H        COPh           Gc Q246         H        COPh           G.sub.3 Q201         H        CN             Gc CH.sub.2 - Q201 H        CN             G.sub.3 Q202         H        CN             Gc Q205         H        CN             Gc Q209         H        CN             Gc Q222         H        CN             Gc Q225         H        CN             Gc Q229         H        CN             Gc Q246         H        CN             G.sub.3 Q201         H        H              Gc Q202         H        H              G.sub.3 Q205         H        H              Gc Q207         H        H              Gc Q222         H        H              Gc Q225         H        H              G.sub.3 Q229         H        H              Gc Q230         H        H              Gc Q231         H        H              G.sub.3 Q237         H        H              Gc Q246         H        H              Gc Q247         H        H              G.sub.3 Q250         H        H              Gc Q259         H        H              G.sub.3 Q260         H        H              Gc Q263         H        H              G.sub.3 Q201         H        Me             Gc Q202         H        Me             G.sub.3 Q205         H        Me             Gc Q207         H        Me             G.sub.3 Q222         H        Me             Gc Q225         H        Me             Gc Q229         H        Me             Gc Q230         H        Me             G.sub.3 Q231         H        Me             Gc Q237         H        Me             Gc Q246         H        Me             Gc Q247         H        Me             G.sub.3 Q250         H        Me             Gc Q259         H        Me             Gc Q260         H        Me             Gc Q263         H        Me             G.sub.3 Q201         H        Et             Gc Q202         H        Et             G.sub.1 Q205         H        Et             Gc Q209         H        Et             Gc Q222         H        Et             G.sub.3 Q225         H        Et             Gc Q229         H        Et             Gc Q246         H        Et             G.sub.2 Q201         H        Pri            Gc Q205         H        Pri            Gc Q209         H        Pri            Gc Q222         H        Pri            G.sub.3 Q229         H        Pri            Gc Q201         H        CHCH.sub.2     Gc Q205         H        CHCH.sub.2     G.sub.3 Q209         H        CHCH.sub.2     Gc Q229         H        CHCH.sub.2     G.sub.3 Q201         H        CHCHMe         Gc Q205         H        CHCHMe         Gc Q201         H        CH.sub.2 CHCH.sub.2 Gc Q205         H        CH.sub.2 CHCH.sub.2 G.sub.3 Q209         H        CH.sub.2 CHCH.sub.2 Gc Q229         H        CH.sub.2 CHCH.sub.2 Gc Q201         H        CH.sub.2 Cl    Gc Q205         H        CH.sub.2 Cl    G.sub.3 Q209         H        CH.sub.2 Cl    Gc Q229         H        CH.sub.2 Cl    Gc Q201         H        CH.sub.2 CH.sub.2 Cl Gc Q205         H        CH.sub.2 CH.sub.2 Cl G.sub.3 Q209         H        CH.sub.2 CH.sub.2 Cl Gc Q229         H        CH.sub.2 CH.sub.2 Cl G.sub.2 Q201         H        CF.sub.3       Gc Q205         H        CF.sub.3       G.sub.3 Q209         H        CF.sub.3       Gc Q222         H        CF.sub.3       Gc Q225         H        CF.sub.3       G.sub.3 Q229         H        CF.sub.3       G.sub.1 Q201         H        CFCFCl         Gc Q205         H        CFCFCl         Gc Q229         H        CFCFCl         G.sub.3 Q201         H        CH.sub.2 Ph    Gc Q205         H        CH.sub.2 Ph    Gc Q209         H        CH.sub.2 Ph    G.sub.3 Q201         H        Ph             Gc Q202         H        Ph             G.sub.1 Q205         H        Ph             Gc Q209         H        Ph             Gc Q222         H        Ph             G.sub.3 Q225         H        Ph             Gc Q229         H        Ph             Gc Q246         H        Ph             G.sub.2 Q201         H        Ph2-Cl         Gc Q205         H        Ph2-Cl         G.sub.1 Q209         H        Ph2-Cl         Gc Q201         H        Ph2-Me         Gc Q205         H        Ph2-Me         G.sub.3 Q209         H        Ph2-Me         Gc Q225         H        Ph2-Me         Gc Q229         H        Ph2-Me         G.sub.3 Q201         H        Cl             Gc Q205         H        Cl             Gc Q207         H        Cl             G.sub.3 Q222         H        Cl             Gc Q225         H        Cl             Gc Q229         H        Cl             G.sub.1 Q231         H        Cl             Gc Q246         H        Cl             Gc Q250         H        Cl             G.sub.3 Q259         H        Cl             Gc Q260         H        Cl             Gc Q201         H        Br             Gc Q205         H        Br             G.sub.3 Q207         H        Br             Gc Q229         H        Br             Gc Q231         H        Br             G.sub.3 Q250         H        Br             Gc Q259         H        Br             Gc Q260         H        Br             G.sub.3 Q201         H        F              Gc Q205         H        F              G.sub.3 Q209         H        F              Gc Q229         H        F              Gc Q246         H        F              G.sub.3 Q201         H        I              Gc Q205         H        I              Gc Q209         H        I              Gc Q222         H        I              Gc Q201         H        NO.sub.2       Gc CH.sub.2 - Q201 H        NO.sub.2       G.sub.3 Q202         H        NO.sub.2       G.sub.3 Q205         H        NO.sub.2       Gc Q207         H        NO.sub.2       Gc Q222         H        NO.sub.2       G.sub.3 Q225         H        NO.sub.2       Gc Q229         H        NO.sub.2       Gc Q230         H        NO.sub.2       G.sub.1 Q231         H        NO.sub.2       Gc Q237         H        NO.sub.2       Gc Q246         H        NO.sub.2       Gc Q247         H        NO.sub.2       G.sub.2 Q250         H        NO.sub.2       Gc Q259         H        NO.sub.2       Gc Q260         H        NO.sub.2       G.sub.3 Q263         H        NO.sub.2       Gc Q201         H        NH.sub.2       Gc Q202         H        NH.sub.2       G.sub.3 Q205         H        NH.sub.2       Gc Q209         H        NH.sub.2       Gc Q222         H        NH.sub.2       G.sub.3 Q225         H        NH.sub.2       Gc Q229         H        NH.sub.2       Gc Q246         H        NH.sub.2       G.sub.3 Q201         H        NHMe           Gc Q205         H        NHMe           Gc Q209         H        NHMe           Gc Q225         H        NHMe           Gc Q229         H        NHMe           G.sub.3 Q201         H        NMe.sub.2      Gc Q205         H        NMe.sub.2      Gc Q209         H        NMe.sub.2      Gc Q222         H        NMe.sub.2      G.sub.1 Q225         H        NMe.sub.2      Gc Q229         H        NMe.sub.2      Gc Q246         H        NMe.sub.2      G.sub.3 Q201         H        NMeEt          Gc Q205         H        NMeEt          Gc Q209         H        NMeEt          G.sub.3 Q222         H        NMeEt          Gc Q225         H        NMeEt          Gc Q229         H        NMeEt          G.sub.2 Q201         H        NHCOMe         Gc Q202         H        NHCOMe         G.sub.3 Q205         H        NHCOMe         Gc Q209         H        NHCOMe         Gc Q222         H        NHCOMe         G.sub.3 Q225         H        NHCOMe         Gc Q229         H        NHCOMe         Gc Q246         H        NHCOMe         G.sub.3 Q201         H        NHCOEt         Gc Q205         H        NHCOEt         Gc Q209         H        NHCOEt         Gc Q222         H        NHCOEt         G.sub.1 Q225         H        NHCOEt         Gc Q229         H        NHCOEt         G.sub.3 Q201         H        NHSO.sub.2 Me  Gc Q205         H        NHSO.sub.2 Me  Gc Q209         H        NHSO.sub.2 Me  Gc Q225         H        NHSO.sub.2 Me  G.sub.3 Q229         H        NHSO.sub.2 Me  G.sub.3 Q201         H        OMe            Gc Q205         H        OMe            Gc Q209         H        OMe            G.sub.3 Q222         H        OMe            Gc Q225         H        OMe            Gc Q229         H        OMe            G.sub.2 Q246         H        OMe            G.sub.1 Q201         H        OEt            Gc Q205         H        OEt            Gc Q209         H        OEt            Gc Q222         H        OEt            G.sub.3 Q229         H        OEt            Gc Q201         H        CH.sub.2 OMe   Gc Q205         H        CH.sub.2 OMe   Gc Q209         H        CH.sub.2 OMe   G.sub.3 Q222         H        CH.sub.2 OMe   Gc Q201         H        SMe            Gc Q205         H        SMe            Gc Q209         H        SMe            Gc Q222         H        SMe            G.sub.1 Q225         H        SMe            Gc Q229         H        SMe            G.sub.3 Q201         H        SO.sub.2 Me    Gc CH.sub.2 - Q201 H        SO.sub.2 Me    G.sub.3 Q202         H        SO.sub.2 Me    Gc Q205         H        SO.sub.2 Me    Gc Q209         H        SO.sub.2 Me    Gc Q222         H        SO.sub.2 Me    G.sub.3 Q225         H        SO.sub.2 Me    Gc Q229         H        SO.sub.2 Me    Gc Q246         H        SO.sub.2 Me    G.sub.3 Q201         H        SO.sub.2 Ph    Gc Q202         H        SO.sub.2 Ph    G.sub.1 Q205         H        SO.sub.2 Ph    Gc Q209         H        SO.sub.2 Ph    Gc Q222         H        SO.sub.2 Ph    Gc Q225         H        SO.sub.2 Ph    G.sub.3 Q229         H        SO.sub.2 Ph    Gc Q246         H        SO.sub.2 Ph    G.sub.1 Q201         H        SO.sub.2 OMe   Gc Q205         H        SO.sub.2 OMe   Gc Q209         H        SO.sub.2 OMe   Gc Q222         H        SO.sub.2 OMe   Gc Q229         H        SO.sub.2 OMe   G.sub.3 Q201         H        SO.sub.2 NH.sub.2 Gc Q205         H        SO.sub.2 NH.sub.2 Gc Q209         H        SO.sub.2 NH.sub.2 G.sub.3 Q225         H        SO.sub.2 NH.sub.2 Gc Q229         H        SO.sub.2 NH.sub.2 Gc Q246         H        SO.sub.2 NH.sub.2 G.sub.1 Q201         H        SO.sub.2 NHMe  Gc Q205         H        SO.sub.2 NHMe  Gc Q209         H        SO.sub.2 NHMe  G.sub.3 Q222         H        SO.sub.2 NHMe  Gc Q225         H        SO.sub.2 NHMe  Gc Q229         H        SO.sub.2 NHMe  Gc Q246         H        SO.sub.2 NHMe  G.sub.2 Q201         H        SO.sub.2 NMe.sub.2 Gc Q202         H        SO.sub.2 NMe.sub.2 G.sub.3 Q205         H        SO.sub.2 NMe.sub.2 Gc Q209         H        SO.sub.2 NMe.sub.2 Gc Q222         H        SO.sub.2 NMe.sub.2 G.sub.2 Q225         H        SO.sub.2 NMe.sub.2 Gc Q229         H        SO.sub.2 NMe.sub.2 Gc Q246         H        SO.sub.2 NMe.sub.2 G.sub.3 Q201         Me       COOMe          Gc CH.sub.2 - Q201 Me       COOMe          G.sub.3 Q202         Me       COOMe          G.sub.1 Q205         Me       COOMe          Gc Q207         Me       COOMe          G.sub.3 Q209         Me       COOMe          Gc Q222         Me       COOMe          Gc Q225         Me       COOMe          G.sub.2 Q229         Me       COOMe          Gc Q230         Me       COOMe          Gc Q231         Me       COOMe          G.sub.3 Q237         Me       COOMe          Gc Q246         Me       COOMe          Gc Q247         Me       COOMe          G.sub.3 Q250         Me       COOMe          Gc Q259         Me       COOMe          G.sub.1 Q260         Me       COOMe          Gc Q263         Me       COOMe          G.sub.3 Q201         Me       COOEt          Gc CH.sub.2 - Q201 Me       COOEt          G.sub.2 Q222         Me       COOEt          Gc Q205         Me       COOEt          Gc Q207         Me       COOEt          G.sub.3 Q209         Me       COOEt          Gc Q222         Me       COOEt          Gc Q225         Me       COOEt          G.sub.3 Q229         Me       COOEt          Gc Q230         Me       COOEt          Gc Q231         Me       COOEt          Gc Q237         Me       COOEt          G.sub.1 Q246         Me       COOEt          Gc Q247         Me       COOEt          Gc Q250         Me       COOEt          Gc Q259         Me       COOEt          G.sub.3 Q260         Me       COOEt          Gc Q263         Me       COOEt          G.sub.3 Q201         Me       COOH           G.sub.1 Q205         Me       COOH           Gc Q201         Me       COOPri         Gc Q202         Me       COOPri         G.sub.3 Q205         Me       COOPri         Gc Q209         Me       COOPri         Gc Q222         Me       COOPri         G.sub.3 Q225         Me       COOPri         Gc Q229         Me       COOPri         Gc Q246         Me       COOPri         G.sub.1 Q201         Me       COOCH.sub.2 CH.sub.2 Cl Gc Q205         Me       COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q222         Me       COOCH.sub.2 CH.sub.2 Cl Gc Q229         Me       COOCH.sub.2 CH.sub.2 Cl G.sub.1 Q201         Me       COOCH.sub.2 CHCH.sub.2 Gc Q205         Me       COOCH.sub.2 CHCH.sub.2 G.sub.3 Q222         Me       COOCH.sub.2 CHCH.sub.2 Gc Q229         Me       COOCH.sub.2 CHCH.sub.2 G.sub.1 Q201         Me       COOCH.sub.2 CCH Gc Q205         Me       COOCH.sub.2 CCH G.sub.2 Q222         Me       COOCH.sub.2 CCH Gc Q229         Me       COOCH.sub.2 CCH Gc Q201         Me       CONHMe         Gc Q205         Me       CONHMe         G.sub.3 Q222         Me       CONHMe         Gc Q229         Me       CONHMe         Gc Q201         Me       CONMe.sub.2    Gc Q205         Me       CONMe.sub.2    G.sub.3 Q222         Me       CONMe.sub.2    Gc Q229         Me       CONMe.sub.2    Gc Q201         Me       COMe           Gc Q202         Me       COMe           G.sub.3 Q205         Me       COMe           Gc Q207         Me       COMe           Gc Q222         Me       COMe           G.sub.3 Q225         Me       COMe           Gc Q229         Me       COMe           Gc Q230         Me       COMe           G.sub.3 Q231         Me       COMe           Gc Q237         Me       COMe           Gc Q246         Me       COMe           Gc Q247         Me       COMe           G.sub.2 Q250         Me       COMe           Gc Q259         Me       COMe           Gc Q260         Me       COMe           G.sub.1 Q263         Me       COMe           Gc Q201         Me       COEt           Gc Q205         Me       COEt           G.sub.3 Q222         Me       COEt           Gc Q229         Me       COEt           Gc Q201         Me       COPri          Gc Q205         Me       COPri          G.sub.3 Q222         Me       COPri          Gc Q229         Me       COPri          G.sub.1 Q201         Me       COPh           Gc Q205         Me       COPh           Gc Q222         Me       COPh           G.sub.3 Q229         Me       COPh           Gc Q201         Me       CN             Gc Q202         Me       CN             G.sub.3 Q205         Me       CN             Gc Q209         Me       CN             Gc Q222         Me       CN             G.sub.3 Q225         Me       CN             Gc Q229         Me       CN             Gc Q246         Me       CN             G.sub.1 Q201         Me       H              Gc Q205         Me       H              Gc Q222         Me       H              G.sub.3 Q229         Me       H              Gc Q201         Me       Me             Gc Q202         Me       Me             G.sub.3 Q205         Me       Me             Gc Q209         Me       Me             Gc Q222         Me       Me             Gc Q225         Me       Me             Gc Q229         Me       Me             G.sub.3 Q246         Me       Me             Gc Q201         Me       Et             Gc Q205         Me       Et             Gc Q222         Me       Et             G.sub.3 Q229         Me       Et             Gc Q201         Me       Pri            Gc Q205         Me       Pri            G.sub.2 Q201         Me       CHCH.sub.2     Gc Q205         Me       CHCH.sub.2     G.sub.3 Q201         Me       CHCHMe         G.sub.3 Q205         Me       CHCHMe         Gc Q201         Me       CH.sub.2 CHCH.sub.2 Gc Q205         Me       CH.sub.2 CHCH.sub.2 G.sub.3 Q201         Me       CH.sub.2 Cl    Gc Q205         Me       CH.sub.2 Cl    G.sub.2 Q222         Me       CH.sub.2 Cl    Gc Q229         Me       CH.sub.2 Cl    G.sub.3 Q201         Me       CH.sub.2 CH.sub.2 Cl Gc Q205         Me       CH.sub.2 CH.sub.2 Cl Gc Q222         Me       CH.sub.2 CH.sub.2 Cl G.sub.3 Q229         Me       CH.sub.2 CH.sub.2 Cl Gc Q201         Me       CF.sub.3       Gc Q205         Me       CF.sub.3       G.sub.3 Q222         Me       CF.sub.3       G.sub.3 Q229         Me       CF.sub.3       Gc Q201         Me       CFCFCl         Gc Q205         Me       CFCFCl         G.sub.3 Q201         Me       CH.sub.2 Ph    Gc Q205         Me       CH.sub.2 Ph    G.sub.3 Q201         Me       Ph             Gc Q202         Me       Ph             Gc Q205         Me       Ph             Gc Q209         Me       Ph             Gc Q222         Me       Ph             G.sub.3 Q225         Me       Ph             G.sub.3 Q229         Me       Ph             Gc Q246         Me       Ph             G.sub.3 Q201         Me       Ph2-Cl         Gc Q205         Me       Ph2-Cl         G.sub.3 Q201         Me       Ph2-Me         Gc Q205         Me       Ph2-Me         Gc Q229         Me       Ph2-Me         G.sub.3 Q201         Me       Cl             Gc Q202         Me       Cl             G.sub.3 Q205         Me       Cl             Gc Q209         Me       Cl             Gc Q222         Me       Cl             G.sub.3 Q225         Me       Cl             Gc Q229         Me       Cl             Gc Q246         Me       Cl             G.sub.3 Q201         Me       Br             Gc Q205         Me       Br             G.sub.3 Q222         Me       Br             Gc Q229         Me       Br             G.sub.1 Q201         Me       F              G.sub.1 Q205         Me       F              G.sub.1 Q201         Me       I              G.sub.1 Q205         Me       I              G.sub.1 Q201         Me       NO.sub.2       Gc Q202         Me       NO.sub.2       G.sub.3 Q205         Me       NO.sub.2       Gc Q209         Me       NO.sub.2       Gc Q222         Me       NO.sub.2       Gc Q225         Me       NO.sub.2       G.sub.3 Q229         Me       NO.sub.2       Gc Q246         Me       NO.sub.2       Gc Q201         Me       NH.sub.2       Gc Q205         Me       NH.sub.2       G.sub.3 Q222         Me       NH.sub.2       Gc Q229         Me       NH.sub.2       G.sub. 3 Q201         Me       NHMe           Gc Q205         Me       NHMe           Gc Q229         Me       NHMe           G.sub.3 Q201         Me       NMe.sub.2      Gc Q205         Me       NMe.sub.2      Gc Q229         Me       NMe.sub.2      G.sub.3 Q201         Me       NMeEt          Gc Q205         Me       NMeEt          Gc Q201         Me       NHCOMe         Gc Q205         Me       NHCOMe         Gc Q222         Me       NHCOMe         G.sub.3 Q229         Me       NHCOMe         Gc Q201         Me       NHCOEt         Gc Q205         Me       NHCOEt         G.sub.3 Q201         Me       NHSO.sub.2 Me  Gc Q205         Me       NHSO.sub.2 Me  Gc Q229         Me       NHSO.sub.2 Me  G.sub.2 Q201         Me       OMe            Gc Q205         Me       OMe            G.sub.3 Q222         Me       OMe            Gc Q229         Me       OMe            G.sub.1 Q201         Me       OEt            Gc Q205         Me       OEt            G.sub.3 Q201         Me       CH.sub.2 OMe   Gc Q205         Me       CH.sub.2 OMe   Gc Q229         Me       CH.sub.2 OMe   G.sub.3 Q201         Me       SMe            Gc Q205         Me       SMe            G.sub.3 Q201         Me       SO.sub.2 Me    Gc Q205         Me       SO.sub.2 Me    Gc Q222         Me       SO.sub.2 Me    G.sub.1 Q229         Me       SO.sub.2 Me    G.sub.3 Q201         Me       SO.sub.2 Ph    Gc Q205         Me       SO.sub.2 Ph    Gc Q222         Me       SO.sub.2 Ph    G.sub.3 Q229         Me       SO.sub.2 Ph    Gc Q201         Me       SO.sub.2 OMe   Gc Q205         Me       SO.sub.2 OMe   G.sub.3 Q229         Me       SO.sub.2 OMe   Gc Q201         Me       SO.sub.2 NH.sub.2 Gc Q205         Me       SO.sub.2 NH.sub.2 Gc Q229         Me       SO.sub.2 NH.sub.2 G.sub.3 Q201         Me       SO.sub.2 NHMe  Gc Q205         Me       SO.sub.2 NHMe  Gc Q222         Me       SO.sub.2 NHMe  G.sub.1 Q229         Me       SO.sub.2 NHMe  Gc Q201         Me       SO.sub.2 NMe.sub.2 Gc Q205         Me       SO.sub.2 NMe.sub.2 G.sub.3 Q222         Me       SO.sub.2 NMe.sub.2 Gc Q229         Me       SO.sub.2 NMe.sub.2 G.sub.1 Q201         Et       COOMe          Gc Q205         Et       COOMe          Gc Q229         Et       COOMe          G.sub.3 Q246         Et       COOMe          G.sub.3 Q201         Et       COOEt          Gc Q202         Et       COOEt          G.sub.2 Q209         Et       COOEt          Gc Q222         Et       COOEt          G.sub.3 Q225         Et       COOEt          Gc Q201         Et       COOPri         G.sub.3 Q205         Et       COOPri         Gc Q201         Et       COOCH.sub.2 CHCl Gc Q205         Et       COOCH.sub.2 CHCH.sub.2 G.sub.3 Q201         Et       COOCH.sub.2 CCH Gc Q201         Et       CONHMe         Gc Q201         Et       CONMe.sub.2    Gc Q201         Et       COMe           Gc Q205         Et       COMe           G.sub.3 Q229         Et       COMe           Gc Q201         Et       COEt           Gc Q201         Et       COPh           Gc Q201         Et       CN             Gc Q205         Et       CN             G.sub.3 Q229         Et       CN             Gc Q201         Et       H              Gc Q205         Et       H              G.sub.3 Q201         Et       Me             Gc Q205         Et       Me             G.sub.3 Q201         Et       Et             Gc Q205         Et       Pri            Gc Q201         Et       CHCHMe         Gc Q201         Et       CH.sub.2 CH.sub.2 Cl Gc Q201         Et       CH.sub.2 Ph    G.sub.3 Q201         Et       Ph             Gc Q205         Et       Ph             Gc Q209         Et       Ph             Gc Q229         Et       Ph             G.sub.3 Q201         Et       Ph2-Cl         Gc Q205         Et       Ph2-Me         Gc Q201         Et       Cl             Gc Q205         Et       Cl             G.sub.2 Q201         Et       Br             Gc Q205         Et       Br             G.sub.1 Q201         Et       F              Gc Q201         Et       NO.sub.2       Gc Q205         Et       NO.sub.2       G.sub.3 Q209         Et       NO.sub.2       Gc Q201         Et       NH.sub.2       Gc Q201         Et       NHMe           Gc Q201         Et       NMe.sub.2      Gc Q205         Et       NMe.sub.2      G.sub.3 Q201         Et       NHCOMe         Gc Q205         Et       NHCOMe         Gc Q201         Et       NHCOEt         Gc Q201         Et       NHSO.sub.2 Me  Gc Q201         Et       OMe            Gc Q205         Et       OEt            G.sub.3 Q201         Et       CH.sub.2 OMe   Gc Q201         Et       SMe            Gc Q201         Et       SO.sub.2 Me    Gc Q205         Et       SO.sub.2 Me    G.sub.3 Q201         Et       SO.sub.2 Ph    Gc Q205         Et       SO.sub.2 Ph    G.sub.3 Q201         Et       SO.sub.2 OMe   Gc Q201         Et       SO.sub.2 NH.sub.2 Gc Q205         Et       SO.sub.2 NHMe  G.sub.3 Q201         Et       SO.sub.2 NMe.sub.2 Gc Q205         Et       SO.sub.2 NMe.sub.2 G.sub.3 Q201         Cl       COOMe          Gc Q209         Cl       COOMe          G.sub.3 Q229         Cl       COOMe          Gc Q246         Cl       COOMe          G.sub.3 Q201         Cl       COOEt          Gc Q205         Cl       COOEt          Gc Q222         Cl       COOEt          G.sub.1 Q225         Cl       COOEt          Gc Q246         Cl       COOEt          G.sub.3 Q201         Cl       COOPri         Gc Q205         Cl       COOPri         G.sub.3 Q205         Cl       COOCH.sub.2 CH.sub.2 Cl G.sub.3 Q201         Cl       COOCH.sub.2 CHCH.sub.2 Gc Q201         Cl       COOCH.sub.2 CCH G.sub.3 Q201         Cl       CONHMe         Gc Q201         Cl       CONMe.sub.2    G.sub.3 Q201         Cl       COMe           Gc Q205         Cl       COMe           Gc Q201         Cl       COEt           G.sub.3 Q201         Cl       COPri          Gc Q201         Cl       COPh           G.sub.3 Q201         Cl       CN             Gc Q205         Cl       CN             Gc Q201         Cl       H              G.sub.3 Q201         Cl       Me             Gc Q205         Cl       Me             G.sub.3 Q205         Cl       Et             Gc Q201         Cl       Pri            G.sub.3 Q201         Cl       CHCHMe         Gc Q201         Cl       CH.sub.2 CH CH.sub.2 G.sub.1 Q205         Cl       CH.sub.2 CH.sub.2 Cl Gc Q201         Cl       Ph             Gc Q205         Cl       Ph             Gc Q209         Cl       Ph             G.sub.3 Q201         Cl       Ph2-Cl         Gc Q205         Cl       Ph2-Me         G.sub.3 Q201         Cl       Cl             Gc Q205         Cl       Cl             G.sub.3 Q201         Cl       Br             Gc Q201         Cl       NO.sub.2       Gc Q205         Cl       NO.sub.2       G.sub.3 Q209         Cl       NO.sub.2       Gc Q201         Cl       NH.sub.2       Gc Q201         Cl       NHMe           G.sub.1 Q201         Cl       NMe.sub.2      G.sub.3 Q201         Cl       NHCOMe         Gc Q205         Cl       NHCOEt         Gc Q201         Cl       NHSO.sub.2 Me  G.sub.3 Q201         Cl       OMe            Gc Q201         Cl       CH.sub.2 OMe   G.sub.3 Q201         Cl       SO.sub.2 Me    Gc Q201         Cl       SO.sub.2 Ph    Gc Q201         Cl       SO.sub.2 NH.sub.2 G.sub.3 Q201         Cl       SO.sub.2 NMe.sub.2 Gc Q205         Cl       SO.sub.2 NMe.sub.2 Gc Q201         Br       COOMe          Gc Q205         Br       COOMe          G.sub.3 Q209         Br       COOMe          G.sub.3 Q201         Br       COOEt          Gc Q209         Br       COOEt          Gc Q229         Br       COOEt          G.sub.3 Q201         Br       COOPri         G.sub.3 Q201         Br       COOCH.sub.2 CH.sub.2 Cl Gc Q201         Br       COOCH.sub.2 CHCH.sub.2 G.sub.3 Q201         Br       CONHMe         Gc Q201         Br       CONMe.sub.2    G.sub. 3 Q201         Br       COMe           Gc Q205         Br       COMe           G.sub.3 Q201         Br       COEt           Gc Q201         Br       COPh           G.sub.3 Q201         Br       CN             Gc Q205         Br       CN             Gc Q201         Br       H              G.sub.3 Q201         Br       Me             G.sub.2 Q201         Br       Et             G.sub.1 Q201         Br       CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         Br       Ph             Gc Q205         Br       Ph             Gc Q209         Br       Ph             G.sub.3 Q201         Br       Ph2-Cl         G.sub.3 Q201         Br       Cl             Gc Q201         Br       Br             Gc Q205         Br       Br             G.sub.3 Q201         Br       NO.sub.2       Gc Q209         Br       NO.sub.2       Gc Q201         Br       NH.sub.2       Gc Q201         Br       NMe.sub.2      G.sub.3 Q201         Br       NHCOMe         Gc Q201         Br       OMe            G.sub.3 Q201         Br       CH.sub.2 OMe   Gc Q201         Br       SMe            Gc Q201         Br       SO.sub.2 Me    Gc Q201         Br       SO.sub.2 NH.sub.2 G.sub.3 Q201         Br       SO.sub.2 NHMe  Gc Q201         Br       SO.sub.2 NMe.sub.2 G.sub.3 Q201         SMe      COOMe          Gc Q205         SMe      COOMe          Gc Q209         SMe      COOMe          G.sub.3 Q201         SMe      COOEt          Gc Q205         SMe      COOEt          Gc Q209         SMe      COOEt          Gc Q229         SMe      COOEt          G.sub.3 Q246         SMe      COOEt          Gc Q201         SMe      COOPri         Gc Q205         SMe      COOPri         G.sub.3 Q201         SMe      COOCH.sub.2 CH.sub.2 Cl Gc Q201         SMe      COOCH.sub.2 CHCH.sub.2 Gc Q201         SMe      CONHMe         Gc Q201         SMe      CONMe.sub.2    G.sub.1 Q201         SMe      COMe           Gc Q205         SMe      COMe           Gc Q201         SMe      COEt           G.sub.3 Q201         SMe      COPri          Gc Q201         SMe      COPh           G.sub.3 Q201         SMe      CN             Gc Q205         SMe      CN             Gc Q229         SMe      CN             G.sub.3 Q201         SMe      H              Gc Q201         SMe      Me             Gc Q205         SMe      Me             G.sub.3 Q201         SMe      Et             Gc Q205         SMe      Et             Gc Q201         SMe      CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         SMe      Ph             Gc Q205         SMe      Ph             Gc Q209         SMe      Ph             G.sub.3 Q201         SMe      Ph2-Cl         Gc Q201         SMe      Cl             Gc Q205         SMe      Cl             G.sub.3 Q201         SMe      Br             Gc Q201         SMe      NO.sub.2       Gc Q205         SMe      NO.sub.2       Gc Q209         SMe      NO.sub.2       G.sub.3 Q201         SMe      NH.sub.2       Gc Q205         SMe      NH.sub.2       Gc Q201         SMe      NHMe           G.sub.3 Q201         SMe      NMe.sub.2      Gc Q205         SMe      NMe.sub.2      Gc Q201         SMe      NHCOMe         Gc Q205         SMe      NHCOMe         G.sub.3 Q201         SMe      NHSO.sub.2 Me  Gc Q201         SMe      OMe            Gc Q201         SMe      CH.sub.2 OMe   Gc Q201         SMe      SMe            Gc Q201         SMe      SO.sub.2 Me    Gc Q205         SMe      SO.sub.2 Me    G.sub.3 Q201         SMe      SO.sub.2 Ph    Gc Q201         SMe      SO.sub.2 NH.sub.2 Gc Q201         SMe      SO.sub.2 NHMe  G.sub.3 Q201         SMe      SO.sub.2 NMe.sub.2 Gc Q201         SO.sub.2 Me COOMe          Gc Q205         SO.sub.2 Me COOMe          Gc Q209         SO.sub.2 Me COOMe          G.sub.3 Q229         SO.sub.2 Me COOMe          G.sub.3 Q246         SO.sub.2 Me COOMe          G.sub.1 Q201         SO.sub.2 Me COOEt          Gc Q205         SO.sub.2 Me COOEt          Gc Q209         SO.sub.2 Me COOEt          G.sub.3 Q222         SO.sub.2 Me COOEt          Gc Q225         SO.sub.2 Me COOEt          Gc Q201         SO.sub.2 Me COOPri         G.sub.3 Q205         SO.sub.2 Me COOPri         Gc Q201         SO.sub.2 Me COOCH.sub.2 CH.sub.2 Cl Gc Q201         SO.sub.2 Me COOCH.sub.2 CHCH.sub.2 G.sub.3 Q201         SO.sub.2 Me COOCH.sub.2 CCH Gc Q201         SO.sub.2 Me CONHMe         Gc Q201         SO.sub.2 Me CONMe.sub.2    G.sub.2 Q201         SO.sub.2 Me COMe           Gc Q205         SO.sub.2 Me COMe           Gc Q229         SO.sub.2 Me COMe           G.sub.3 Q201         SO.sub.2 Me COEt           Gc Q205         SO.sub.2 Me COEt           Gc Q201         SO.sub.2 Me COPri          G.sub.3 Q201         SO.sub.2 Me COPh           Gc Q201         SO.sub.2 Me CN             Gc Q205         SO.sub.2 Me CN             Gc Q222         SO.sub.2 Me CN             Gc Q229         SO.sub.2 Me CN             Gc Q201         SO.sub.2 Me H              G.sub.2 Q201         SO.sub.2 Me Me             Gc Q205         SO.sub.2 Me Me             Gc Q201         SO.sub.2 Me Et             G.sub.3 Q201         SO.sub.2 Me Pri            Gc Q201         SO.sub.2 Me CHCH.sub.2     Gc Q201         SO.sub.2 Me CHCHMe         G.sub.1 Q201         SO.sub.2 Me CH.sub.2 CH.sub.2 Cl Gc Q205         SO.sub.2 Me CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         SO.sub.2 Me CH.sub.2 Ph    G.sub.3 Q201         SO.sub.2 Me Ph             Gc Q205         SO.sub.2 Me Ph             Gc Q209         SO.sub.2 Me Ph             Gc Q229         SO.sub.2 Me Ph             G.sub.3 Q246         SO.sub.2 Me Ph             G.sub.3 Q201         SO.sub.2 Me Ph2-Cl         Gc Q205         SO.sub.2 Me Ph2-Me         Gc Q201         SO.sub.2 Me Cl             Gc Q205         SO.sub.2 Me Cl             Gc Q229         SO.sub.2 Me Cl             G.sub.3 Q201         SO.sub.2 Me Br             G.sub.3 Q205         SO.sub.2 Me Br             Gc Q201         SO.sub.2 Me NO.sub.2       Gc Q205         SO.sub.2 Me NO.sub.2       Gc Q209         SO.sub.2 Me NO.sub.2       Gc Q229         SO.sub.2 Me NO.sub.2       G.sub.3 Q201         SO.sub.2 Me NH.sub.2       Gc Q205         SO.sub.2 Me NH.sub.2       G.sub.3 Q201         SO.sub.2 Me NHMe           Gc Q201         SO.sub.2 Me NMe.sub.2      Gc Q205         SO.sub.2 Me NMe.sub.2      G.sub.1 Q201         SO.sub.2 Me NHCOMe         Gc Q205         SO.sub.2 Me NHCOMe         Gc Q201         SO.sub.2 Me NHCOEt         G.sub.3 Q201         SO.sub.2 Me NHSO.sub.2 Me  Gc Q201         SO.sub.2 Me OMe            G.sub.1 Q201         SO.sub.2 Me CH.sub.2 OMe   Gc Q205         SO.sub.2 Me CH.sub.2 OMe   Gc Q201         SO.sub.2 Me SO.sub.2 Me    Gc Q205         SO.sub.2 Me SO.sub.2 Me    Gc Q201         SO.sub.2 Me SO.sub.2 Ph    G.sub.3 Q201         SO.sub.2 Me SO.sub.2 OMe   Gc Q201         SO.sub.2 Me SO.sub.2 NH.sub.2 Gc Q201         SO.sub.2 Me SO.sub.2 NHMe  G.sub.3 Q201         SO.sub.2 Me SO.sub.2 NMe.sub.2 Gc Q201         Ph       COOMe          Gc Q205         Ph       COOMe          G.sub.3 Q209         Ph       COOMe          Gc Q201         Ph       COOEt          Gc Q205         Ph       COOEt          Gc Q209         Ph       COOEt          G.sub.3 Q229         Ph       COOEt          Gc Q201         Ph       COOPri         G.sub.3 Q201         Ph       COOCH.sub.2 CH.sub.2 Cl Gc Q201         Ph       COOCH.sub.2 CHCH.sub.2 Gc Q201         Ph       COOCH.sub.2 CCH G.sub.3 Q201         Ph       CONMe.sub.2    Gc Q201         Ph       COMe           Gc Q205         Ph       COMe           Gc Q201         Ph       COEt           G.sub.3 Q201         Ph       CN             Gc Q205         Ph       CN             Gc Q201         Ph       H              G.sub.3 Q201         Ph       Me             Gc Q201         Ph       Et             Gc Q201         Ph       CH.sub.2 CH.sub.2 Cl G.sub.3 Q201         Ph       Ph             Gc Q205         Ph       Ph             Gc Q209         Ph       Ph             G.sub.3 Q201         Ph       Cl             Gc Q201         Ph       Br             G.sub.3 Q201         Ph       NO.sub.2       Gc Q201         Ph       NH.sub.2       Gc Q201         Ph       NHMe           G.sub.3 Q201         Ph       NMe.sub.2      Gc Q201         Ph       NHCOMe         Gc Q201         Ph       NHSO.sub.2 Me  G.sub.1 Q201         Ph       CH.sub.2 OMe   Gc Q201         Ph       SO.sub.2 Me    G.sub.3 Q201         Ph       SO.sub.2 NH.sub.2 Gc Q201         Ph       SO.sub.2 NHMe  Gc Q201         Ph       SO.sub.2 NMe.sub.2 G.sub.3 ______________________________________ ______________________________________ ##STR26## A         B      D      E          W     Gn ______________________________________ Q5        H      H      Me         O     Gc CH.sub.2Q5 H      H      Me         O     Gc Q5        H      H      Et         O     G3 Q5        H      H      Prn        O     G3 Q5        H      H      CH.sub.2 CHCH.sub.2 O     G3 Q5        H      H      OMe        O     G3 Q61       H      H      Me         O     Gc CH.sub.2Q61 H      H      Me         O     Gc Q61       H      H      Et         O     G3 Q61       H      H      Prn        O     G3 Q61       H      H      CH.sub.2 CHCH.sub.2 O     G3 Q61       H      H      OMe        O     G3 Q26       H      H      Me         O     G3 Q26       H      H      Et         O     G3 Q26       H      H      OMe        O     G3 Q5        H      H      H          S     Gc CH.sub.2Q5 H      H      H          S     G3 Q26       H      H      H          S     Gc Q61       H      H      H          S     Gc CH.sub.2Q61 H      H      H          S     G3 Q5        H      H      H          NH    Gc CH.sub.2Q5 H      H      H          NH    G3 Q26       H      H      H          NH    Gc Q61       H      H      H          NH    Gc CH.sub.2Q61 H      H      H          NH    G3 Q5        H      H      H          NOMe  Gc CH.sub.2Q5 H      H      H          NOMe  G3 Q26       H      H      H          NOMe  Gc Q61       H      H      H          NOMe  Gc CH.sub.2Q61 H      H      H          NOMe  G3 Q201      H      H      Me         O     Gc CH.sub.2Q201 H      H      Me         O     G.sub.3 Q201      H      H      Et         O     Gc Q201      H      H      Prn        O     G.sub.3 Q201      H      H      CH.sub.2 CHCH.sub.2 O     Gc Q201      H      H      OMe        O     Gc Q205      H      H      Me         O     G.sub.3 Q205      H      H      Et         O     G.sub.3 Q205      H      H      OMe        O     G.sub.3 Q201      H      H      H          S     Gb CH.sub.2Q201 H      H      H          S     G.sub.3 Q205      H      H      H          S     Gc Q222      H      H      H          S     G.sub.2 Q229      H      H      H          S     G.sub.3 Q201      H      H      H          NH    Gb CH.sub.2Q201 H      H      H          NH    G.sub.3 Q205      H      H      H          NH    Gc Q222      H      H      H          NH    G.sub.3 Q229      H      H      H          NH    G.sub.3 Q201      H      H      H          NOMe  Gb CH.sub.2Q201 H      H      H          NOMe  G.sub.3 Q205      H      H      H          NOMe  Gc Q222      H      H      H          NOMe  Gc Q229      H      H      H          NOMe  G.sub.3 ______________________________________ ______________________________________ ##STR27## A           B      D       W2    R22    Gn ______________________________________ Q5          H      H       O     Me     Gc CH.sub.2Q5  H      H       O     Me     G3 Q5          H      H       O     Et     Gc Q5          H      H       O     Prn    G3 Q26         H      H       O     Me     Gc Q26         H      H       O     Et     G3 Q61         H      H       O     Me     Gc CH.sub.2Q61 H      H       O     Me     Gc Q61         H      H       O     Et     Gc Q61         H      H       O     Prn    G3 Q158        H      H       O     Et     G3 Q158        H      H       O     Me     G3 Q5          H      H       S     Me     Gc CH.sub.2Q5  H      H       S     Me     G3 Q5          H      H       S     Et     Gc Q5          H      H       S     Prn    G3 Q26         H      H       S     Me     Gc Q26         H      H       S     Et     G3 Q61         H      H       S     Me     Gc CH.sub.2Q61 H      H       S     Me     Gc Q61         H      H       S     Et     Gc Q61         H      H       S     Prn    G3 Q158        H      H       S     Et     G3 Q158        H      H       S     Me     G3 Q201        H      H       O     Me     Gc CH.sub.2Q201 H      H       O     Me     G.sub.3 Q201        H      H       O     Et     Gc Q201        H      H       O     Prn    Gc Q205        H      H       O     Me     G.sub.3 Q205        H      H       O     Et     Gc Q222        H      H       O     Me     Gc Q222        H      H       O     Et     G.sub.3 Q229        H      H       O     Me     Gc Q229        H      H       O     Et     G.sub.3 Q201        H      H       S     Me     Gc CH.sub.2Q201 H      H       S     Me     G.sub.3 Q201        H      H       S     Et     Gc Q201        H      H       S     Prn    Gc Q205        H      H       S     Me     Gc Q205        H      H       S     Et     Gc Q222        H      H       S     Me     G.sub.3 Q222        H      H       S     Et     Gc Q229        H      H       S     Me     Gc Q229        H      H       S     Et     G.sub.3 ______________________________________ ______________________________________ ##STR28## A            B      D      Az         Gn ______________________________________ Q5           H      H      Imidazol-1-yl Gc Q5           H      H      Pyrazol-1-yl Gc CH.sub.2Q5   H      H      Imidazol-1-yl G3 CH.sub.2Q5   H      H      Pyrazol-1-yl G3 Q26          H      H      Imidazol-1-yl Gc Q26          H      H      Pyrazol-1-yl Gc Q61          H      H      Imidazol-1-yl Gc Q61          H      H      Pyrazol-1-yl Gc CH.sub.2Q61  H      H      Imidazol-1-yl G3 CH.sub.2Q61  H      H      Pyrazol-1-yl G3 Q158         H      H      Imidazol-1-yl G3 Q158         H      H      Pyrazol-1-yl G3 Q201         H      H      Imidazol-1-yl Gc Q201         H      H      Pyrazol-1-yl Gc CH.sub.2Q201 H      H      Imidazol-1-yl G.sub.3 CH.sub.2Q201 H      H      Pyrazol-1-yl G.sub.3 Q205         H      H      Imidazol-1-yl Gc Q205         H      H      Pyrazol-1-yl Gc Q222         H      H      Imidazol-1-yl G.sub.3 Q222         H      H      Pyrazol-1-yl G.sub.3 Q229         H      H      Imidazol-1-yl Gc Q229         H      H      Pyrazol-1-yl Gc ______________________________________ ______________________________________ ##STR29## A         B       D       J      R23    Gn ______________________________________ Q5        H       H       Me     H      Gc Q5        H       H       Me     Me     G3 Q5        H       H       Me     OMe    Gc Q5        H       H       Et     H      G3 Q5        H       H       Et     Me     G3 Q5        H       H       Et     OMe    Gc Q5        H       H       J1     H      G3 Q5        H       H       J1     Me     G1 Q5        H       H       J1     OMe    G3 Q201      H       H       Me     H      Gc Q201      H       H       Me     Me     G.sub.3 Q201      H       H       Me     OMe    Gc Q201      H       H       Et     H      G.sub.3 Q201      H       H       Et     Me     G.sub.3 Q201      H       H       Et     OMe    Gc Q201      H       H       J10    H      G.sub.3 Q201      H       H       J10    Me     G.sub.1 Q201      H       H       J10    OMe    G.sub.3 ______________________________________ ______________________________________ ##STR30## A        B      D        E         W     Gn ______________________________________ Q5       H      COOMe    Me        O     Gc CH.sub.2Q5 H      COOMe    Me        O     G3 Q5       H      COOMe    Et        O     Gc Q5       H      COOMe    Prn       O     Gc Q5       H      COOMe    CH.sub.2 CHCH.sub.2 O     G3 Q5       H      COOMe    OMe       O     Gc Q26      H      COOMe    Me        O     G3 Q26      H      COOMe    Et        O     Gc Q26      H      COOMe    OMe       O     Gc Q61      H      COOMe    Me        O     Gc CH.sub.2Q61 H      COOMe    Me        O     G3 Q61      H      COOMe    Et        O     Gc Q61      H      COOMe    Prn       O     Gc Q61      H      COOMe    CH.sub.2 CHCH.sub.2 O     G3 Q61      H      COOMe    OMe       O     Gc Q5       H      COOMe    H         S     Gb CH.sub.2Q5 H      COOMe    H         S     G3 Q26      H      COOMe    H         S     Gc Q61      H      COOMe    H         S     Gc CH.sub.2Q61 H      COOMe    H         S     G3 Q5       H      COOMe    H         NH    Gb CH.sub.2Q5 H      COOMe    H         NH    G3 Q26      H      COOMe    H         NH    Gc Q61      H      COOMe    H         NH    Gc CH.sub.2Q61 H      COOMe    H         NH    G3 Q5       H      COOMe    H         NOMe  Gb CH.sub.2Q5 H      COOMe    H         NOMe  G3 Q26      H      COOMe    H         NOMe  Gc Q61      H      COOMe    H         NOMe  Gc CH.sub.2Q61 H      COOMe    H         NOMe  G3 Q5       H      COOEt    Me        O     Gc CH.sub.2Q5 H      COOEt    Me        O     G3 Q5       H      COOEt    Et        O     Gc Q5       H      COOEt    Prn       O     Gc Q5       H      COOEt    CH.sub.2 CHCH.sub.2 O     G3 Q5       H      COOEt    OMe       O     Gc Q26      H      COOEt    Me        O     G3 Q26      H      COOEt    Et        O     Gc Q26      H      COOEt    OMe       O     Gc Q61      H      COOEt    Me        O     Gc CH.sub.2Q61 H      COOEt    Me        O     G3 Q61      H      COOEt    Et        O     Gc Q61      H      COOEt    Prn       O     Gc Q61      H      COOEt    CH.sub.2 CHCH.sub.2 O     G3 Q61      H      COOEt    OMe       O     Gc Q5       H      COOEt    H         S     Gb CH.sub.2Q5 H      COOEt    H         S     G3 Q26      H      COOEt    H         S     Gc Q61      H      COOEt    H         S     Gc CH.sub.2Q61 H      COOEt    H         S     G3 Q5       H      COOEt    H         NH    Gb CH.sub.2Q5 H      COOEt    H         NH    G3 Q26      H      COOEt    H         NH    Gc Q61      H      COOEt    H         NH    Gc CH.sub.2Q61 H      COOEt    H         NH    G3 Q5       H      COOEt    H         NOMe  Gb CH.sub.2Q5 H      COOEt    H         NOMe  G3 Q26      H      COOEt    H         NOMe  Gc Q61      H      COOEt    H         NOMe  Gc CH.sub.2Q61 H      COOEt    H         NOMe  G3 Q201     H      COOMe    Me        O     Gc CH.sub.2Q201 H      COOMe    Me        O     G.sub.3 Q201     H      COOMe    Et        O     Gc Q201     H      COOMe    Prn       O     Gc Q201     H      COOMe    CH.sub.2 CHCH.sub.2 O     G.sub.3 Q201     H      COOMe    OMe       O     Gc Q205     H      COOMe    Me        O     G.sub.3 Q205     H      COOMe    Et        O     Gc Q205     H      COOMe    OMe       O     Gc Q201     H      COOMe    H         S     Gb CH.sub.2Q201 H      COOMe    H         S     G.sub.3 Q205     H      COOMe    H         S     Gc Q222     H      COOMe    H         S     G.sub.3 Q229     H      COOMe    H         S     G.sub.1 Q201     H      COOMe    H         NH    Gb CH.sub.2Q201 H      COOMe    H         NH    G.sub.3 Q205     H      COOMe    H         NH    Gc Q222     H      COOMe    H         NH    Gc Q229     H      COOMe    H         NH    G.sub.3 Q201     H      COOMe    H         NOMe  Gb CH.sub.2Q201 H      COOMe    H         NOMe  G.sub.3 Q205     H      COOMe    H         NOMe  Gc Q222     H      COOMe    H         NOMe  Gc Q229     H      COOMe    H         NOMe  G.sub.3 Q201     H      COOEt    Me        O     Gc CH.sub.2Q201 H      COOEt    Me        O     G.sub.3 Q201     H      COOEt    Et        O     Gc Q201     H      COOEt    Prn       O     Gc Q201     H      COOEt    CH.sub.2 CHCH.sub.2 O     Gc Q201     H      COOEt    OMe       O     Gc Q205     H      COOEt    Me        O     G.sub.3 Q205     H      COOEt    Et        O     G.sub.3 Q205     H      COOEt    OMe       O     Gc Q201     H      COOEt    H         S     Gb CH.sub.2Q201 H      COOEt    H         S     G.sub.3 Q205     H      COOEt    H         S     Gc Q222     H      COOEt    H         S     Gc Q229     H      COOEt    H         S     Gc Q201     H      COOEt    H         NH    Gb CH.sub.2Q201 H      COOEt    H         NH    G.sub.3 Q205     H      COOEt    H         NH    Gc Q222     H      COOEt    H         NH    Gc Q229     H      COOEt    H         NH    Gc Q201     H      COOEt    H         NOMe  Gb CH.sub.2Q201 H      COOEt    H         NOMe  G.sub.3 Q205     H      COOEt    H         NOMe  Gc Q222     H      COOEt    H         NOMe  Gc Q229     H      COOEt    H         NOMe  G.sub. 3 ______________________________________ ______________________________________ ##STR31## A         B       D         W2    R22    Gn ______________________________________ Q5        H       COOMe     O     Me     Gc CH.sub.2Q5 H       COOMe     O     Me     G3 Q5        H       COOMe     O     Et     Gc Q5        H       COOMe     O     Prn    G3 Q26       H       COOMe     O     Me     Gc Q26       H       COOMe     O     Et     G3 Q61       H       COOMe     O     Me     Gc CH.sub.2Q61 H       COOMe     O     Me     G3 Q61       H       COOMe     O     Et     Gc Q61       H       COOMe     O     Prn    G3 Q158      H       COOMe     O     Me     Gc Q158      H       COOMe     O     Et     G3 Q5        H       COOMe     S     Me     Gc CH.sub.2Q5 H       COOMe     S     Me     G3 Q5        H       COOMe     S     Et     Gc Q5        H       COOMe     S     Prn    G3 Q26       H       COOMe     S     Me     Gc Q26       H       COOMe     S     Et     G3 Q61       H       COOMe     S     Me     Gc CH.sub.2Q61 H       COOMe     S     Me     G3 Q61       H       COOMe     S     Et     Gc Q61       H       COOMe     S     Prn    G3 Q158      H       COOMe     S     Me     Gc Q158      H       COOMe     S     Et     G3 Q5        H       COOEt     O     Me     Gc CH.sub.2Q5 H       COOEt     O     Me     G3 Q5        H       COOEt     O     Et     Gc Q5        H       COOEt     O     Prn    G3 Q26       H       COOEt     O     Me     Gc Q26       H       COOEt     O     Et     G3 Q61       H       COOEt     O     Me     Gc CH.sub.2Q61 H       COOEt     O     Me     G3 Q61       H       COOEt     O     Et     Gc Q61       H       COOEt     O     Prn    G3 Q158      H       COOEt     O     Me     Gc Q158      H       COOEt     O     Et     G3 Q5        H       COOEt     S     Me     Gc CH.sub.2Q5 H       COOEt     S     Me     G3 Q5        H       COOEt     S     Et     Gc Q5        H       COOEt     S     Prn    G3 Q26       H       COOEt     S     Me     Gc Q26       H       COOEt     S     Et     G3 Q61       H       COOEt     S     Me     Gc CH.sub.2Q61 H       COOEt     S     Me     G3 Q61       H       COOEt     S     Et     Gc Q61       H       COOEt     S     Prn    G3 Q158      H       COOEt     S     Me     Gc Q158      H       COOEt     S     Et     G3 Q201      H       COOMe     O     Me     Gc CH.sub.2Q201 H       COOMe     O     Me     G3 Q201      H       COOMe     O     Et     Gc Q201      H       COOMe     O     Prn    Gc Q205      H       COOMe     O     Me     Gc Q205      H       COOMe     O     Et     Gc Q222      H       COOMe     O     Me     Gc Q222      H       COOMe     O     Et     G3 Q229      H       COOMe     O     Me     G3 Q229      H       COOMe     O     Et     Gc Q201      H       COOMe     S     Me     Gc CH.sub.2Q201 H       COOMe     S     Me     G3 Q201      H       COOMe     S     Et     Gc Q201      H       COOMe     S     Prn    Gc Q205      H       COOMe     S     Me     Gc Q205      H       COOMe     S     Et     Gc Q222      H       COOMe     S     Me     Gc Q222      H       COOMe     S     Et     G3 Q229      H       COOMe     S     Me     Gc Q229      H       COOMe     S     Et     G3 Q201      H       COOEt     O     Me     Gc CH.sub.2Q201 H       COOEt     O     Me     G3 Q201      H       COOEt     O     Et     Gc Q201      H       COOEt     O     Prn    Gc Q205      H       COOEt     O     Me     Gc Q205      H       COOEt     O     Et     Gc Q222      H       COOEt     O     Me     Gc Q222      H       COOEt     O     Et     G3 Q229      H       COOEt     O     Me     Gc Q229      H       COOEt     O     Et     G3 Q201      H       COOEt     S     Me     Gc CH.sub.2Q201 H       COOEt     S     Me     G3 Q201      H       COOEt     S     Et     Gc Q201      H       COOEt     S     Prn    Gc Q205      H       COOEt     S     Me     Gc Q205      H       COOEt     S     Et     G3 Q222      H       COOEt     S     Me     Gc Q222      H       COOEt     S     Et     Gc Q229      H       COOEt     S     Me     G1 Q229      H       COOEt     S     Et     G1 ______________________________________ ______________________________________ ##STR32## A           B      D         Az        Gn ______________________________________ Q5          H      COOMe     Imidazol-1-yl Gc Q5          H      COOMe     Pyrazol-1-yl Gc CH.sub.2Q5  H      COOMe     Imidazol-1-yl G1 CH.sub.2Q5  H      COOMe     Pyrazol-1-yl G1 Q26         H      COOMe     Imidazol-1-yl Gc Q26         H      COOMe     Pyrazol-1-yl Gc Q61         H      COOMe     Imidazol-1-yl Gc Q61         H      COOMe     Pyrazol-1-yl Gc CH.sub.2Q61 H      COOMe     Imidazol-1-yl G3 CH.sub.2Q61 H      COOMe     Pyrazol-1-yl G3 Q5          H      COOEt     Imidazol-1-yl Gc Q5          H      COOEt     Pyrazol-1-yl Gc CH.sub.2Q5  H      COOEt     Imidazol-1-yl G3 CH.sub.2Q5  H      COOEt     Pyrazol-1-yl G3 Q26         H      COOEt     Imidazol-1-yl Gc Q26         H      COOEt     Pyrazol-1-yl Gc Q61         H      COOEt     Imidazol-1-yl Gc Q61         H      COOEt     Pyrazol-1-yl Gc CH.sub.2Q61 H      COOEt     Imidazol-1-yl G3 CH.sub.2Q61 H      COOEt     Pyrazol-1-yl G3 Q201        H      COOMe     Imidazol-1-yl Gc Q201        H      COOMe     Pyrazol-1-yl Gc CH.sub.2Q201 H      COOMe     Imidazol-1-yl G1 CH.sub.2Q201 H      COOMe     Pyrazol-1-yl G1 Q205        H      COOMe     Imidazol-1-yl Gc Q205        H      COOMe     Pyrazol-1-yl Gc Q222        H      COOMe     Imidazol-1-yl Gc Q222        H      COOMe     Pyrazol-1-yl Gc Q229        H      COOMe     Imidazol-1-yl G3 Q229        H      COOMe     Pyrazol-1-yl G3 Q201        H      COOEt     Imidazol-1-yl Gc Q201        H      COOEt     Pyrazol-1-yl Gc CH.sub.2Q201 H      COOEt     Imidazol-1-yl G3 CH.sub.2Q201 H      COOEt     Pyrazol-1-yl G3 Q205        H      COOEt     Imidazol-1-yl Gc Q205        H      COOEt     Pyrazol-1-yl Gc Q222        H      COOEt     Imidazol-1-yl Gc Q222        H      COOEt     Pyrazol-1-yl Gc Q229        H      COOEt     Imidazol-1-yl G3 Q229        H      COOEt     Pyrazol-1-yl G3 ______________________________________ ______________________________________ ##STR33## A           B      D         J     R23   Gn ______________________________________ Q5          H      COOMe     Me    H     G3 Q5          H      COOMe     Me    Me    Gc Q5          H      COOMe     Me    OMe   Gc Q5          H      COOMe     Et    H     Gc Q5          H      COOMe     Et    Me    Gc Q5          H      COOMe     Et    OMe   G3 Q5          H      COOMe     J2    H     Gc Q5          H      COOMe     J2    Me    Gc Q5          H      COOMe     J2    OMe   G3 Q5          H      COOEt     Me    H     Gc Q5          H      COOEt     Me    Me    G3 Q5          H      COOEt     Me    OMe   Gc Q5          H      COOEt     Et    H     Gc Q5          H      COOEt     Et    Me    G3 Q5          H      COOEt     Et    OMe   Gc Q5          H      COOEt     J3    H     Gc Q5          H      COOEt     J3    Me    Gc Q5          H      COOEt     J3    OMe   Gc CH.sub.2Q5  H      COOMe     Me    H     G3 CH.sub.2Q5  H      COOEt     Me    OMe   Gc Q26         H      COOMe     Me    H     Gc Q26         H      COOEt     Me    OMe   Gc Q61         H      COOMe     Me    H     G3 Q61         H      COOMe     Me    Me    Gc Q61         H      COOMe     Me    OMe   Gc Q61         H      COOMe     Et    H     Gc Q61         H      COOMe     Et    Me    Gc Q61         H      COOMe     Et    OMe   G3 Q61         H      COOMe     J4    H     Gc Q61         H      COOMe     J4    Me    Gc Q61         H      COOMe     J4    OMe   G3 Q61         H      COOEt     Me    H     Gc Q61         H      COOEt     Me    Me    G3 Q61         H      COOEt     Me    OMe   Gc Q61         H      COOEt     Et    H     Gc Q61         H      COOEt     Et    Me    G3 Q61         H      COOEt     Et    OMe   Gc Q61         H      COOEt     J5    H     Gc Q61         H      COOEt     J5    Me    Gc Q61         H      COOEt     J5    OMe   Gc CH.sub.2Q61 H      COOMe     Me    H     G3 CH.sub.2Q61 H      COOEt     Me    OMe   Gc Q201        H      COOMe     Me    H     G3 Q201        H      COOMe     Me    Me    Gc Q201        H      COOMe     Me    OMe   Gc Q201        H      COOMe     Et    H     Gc Q201        H      COOMe     Et    Me    Gc Q201        H      COOMe     Et    OMe   G3 Q201        H      COOMe     J11   H     Gc Q201        H      COOMe     J11   Me    Gc Q201        H      COOMe     J11   OMe   G3 Q201        H      COOEt     Me    H     Gc Q201        H      COOEt     Me    Me    G3 Q201        H      COOEt     Me    OMe   Gc Q201        H      COOEt     Et    H     Gc Q201        H      COOEt     Et    Me    G3 Q201        H      COOEt     Et    OMe   Gc Q201        H      COOEt     J12   H     Gc Q201        H      COOEt     J12   Me    Gc Q201        H      COOEt     J12   OMe   Gc CH.sub.2Q201 H      COOMe     Me    H     G3 CH.sub.2Q201 H      COOEt     Me    OMe   Gc Q205        H      COOMe     Me    H     Gc Q205        H      COOEt     Me    OMe   Gc Q229        H      COOMe     Me    H     Gc Q229        H      COOEt     Me    OMe   G3 ______________________________________ ______________________________________ ##STR34## A        B      D        E         W     Gn ______________________________________ Q5       H      COOMe    Me        O     Gc CH.sub.2Q5 H      COOMe    Me        O     G3 Q5       H      COOMe    Et        O     Gc Q5       H      COOMe    Prn       O     Gc Q5       H      COOMe    CH.sub.2 CHCH.sub.2 O     G3 Q5       H      COOMe    OMe       O     Gc Q26      H      COOMe    Me        O     G3 Q26      H      COOMe    Et        O     Gc Q26      H      COOMe    OMe       O     Gc Q61      H      COOMe    Me        O     Gc CH.sub.2Q61 H      COOMe    Me        O     G3 Q61      H      COOMe    Et        O     Gc Q61      H      COOMe    Prn       O     Gc Q61      H      COOMe    CH.sub.2 CHCH.sub.2 O     G3 Q61      H      COOMe    OMe       O     Gc Q5       H      COOMe    H         S     Gb CH.sub.2Q5 H      COOMe    H         S     G3 Q26      H      COOMe    H         S     Gc Q61      H      COOMe    H         S     Gc CH.sub.2Q61 H      COOMe    H         S     G3 Q5       H      COOMe    H         NH    Gb CH.sub.2Q5 H      COOMe    H         NH    G3 Q26      H      COOMe    H         NH    Gc Q61      H      COOMe    H         NH    Gc CH.sub.2Q61 H      COOMe    H         NH    G3 Q5       H      COOMe    H         NOMe  Gb CH.sub.2Q5 H      COOMe    H         NOMe  G3 Q26      H      COOMe    H         NOMe  Gc Q61      H      COOMe    H         NOMe  Gc CH.sub.2Q61 H      COOMe    H         NOMe  G3 Q5       H      COOEt    Me        O     Gc CH.sub.2Q5 H      COOEt    Me        O     G3 Q5       H      COOEt    Et        O     Gc Q5       H      COOEt    Prn       O     Gc Q5       H      COOEt    CH.sub.2 CHCH.sub.2 O     G3 Q5       H      COOEt    OMe       O     Gc Q26      H      COOEt    Me        O     G3 Q26      H      COOEt    Et        O     Gc Q26      H      COOEt    OMe       O     Gc Q61      H      COOEt    Me        O     Gc CH.sub.2Q61 H      COOEt    Me        O     G3 Q61      H      COOEt    Et        O     Gc Q61      H      COOEt    Prn       O     Gc Q61      H      COOEt    CH.sub.2 CHCH.sub.2 O     G3 Q61      H      COOEt    OMe       O     Gc Q5       H      COOEt    H         S     Gb CH.sub.2Q5 H      COOEt    H         S     G3 Q26      H      COOEt    H         S     Gc Q61      H      COOEt    H         S     Gc CH.sub.2Q61 H      COOEt    H         S     G3 Q5       H      COOEt    H         NH    Gb CH.sub.2Q5 H      COOEt    H         NH    G3 Q26      H      COOEt    H         NH    Gc Q61      H      COOEt    H         NH    Gc CH.sub.2Q61 H      COOEt    H         NH    G3 Q5       H      COOEt    H         NOMe  Gb CH.sub.2Q5 H      COOEt    H         NOMe  G3 Q26      H      COOEt    H         NOMe  Gc Q61      H      COOEt    H         NOMe  Gc CH.sub.2Q61 H      COOEt    H         NOMe  G3 Q201     H      COOMe    Me        O     Gc CH.sub.2Q201 H      COOMe    Me        O     G3 Q201     H      COOMe    Et        O     Gc Q201     H      COOMe    Prn       O     Gc Q201     H      COOMe    CH.sub.2 CHCH.sub.2 O     G3 Q201     H      COOMe    OMe       O     Gc Q205     H      COOMe    Me        O     G3 Q205     H      COOMe    Et        O     Gc Q205     H      COOMe    OMe       O     Gc Q201     H      COOMe    H         S     Gb CH.sub.2Q201 H      COOMe    H         S     G3 Q205     H      COOMe    H         S     Gc Q222     H      COOMe    H         S     G3 Q229     H      COOMe    H         S     G1 Q201     H      COOMe    H         NH    Gb CH.sub.2Q201 COOMe  H        NH        G3 Q205     H      COOMe    H         NH    Gc Q222     H      COOMe    H         NH    Gc Q229     H      COOMe    H         NH    G3 Q201     H      COOMe    H         NOMe  Gb CH.sub.2 Q201 H      COOMe    H         NOMe  G3 Q205     H      COOMe    H         NOMe  Gc Q222     H      COOMe    H         NOMe  Gc Q229     H      COOMe    H         NOMe  G3 Q201     H      COOEt    Me        O     Gc CH.sub.2Q201 H      COOEt    Me        O     G3 Q201     H      COOEt    Et        O     Gc Q201     H      COOEt    Prn       O     Gc Q201     H      COOEt    CH.sub.2 CHCH.sub.2 O     Gc Q201     H      COOEt    OMe       O     Gc Q205     H      COOEt    Me        O     G3 Q205     H      COOEt    Et        O     G3 Q205     H      COOEt    OMe       O     Gc Q201     H      COOEt    H         S     Gb CH.sub.2Q201 H      COOEt    H         S     G3 Q205     H      COOEt    H         S     Gc Q222     H      COOEt    H         S     Gc Q229     H      COOEt    H         S     Gc Q201     H      COOEt    H         NH    Gb CH.sub.2Q201 H      COOEt    H         NH    G3 Q205     H      COOEt    H         NH    Gc Q222     H      COOEt    H         NH    Gc Q229     H      COOEt    H         NH    Gc Q201     H      COOEt    H         NOMe  Gb CH.sub.2Q201 H      COOEt    H         NOMe  G3 Q205     H      COOEt    H         NOMe  Gc Q222     H      COOEt    H         NOMe  Gc Q229     H      COOEt    H         NOMe  G3 ______________________________________ ______________________________________ ##STR35## A         B         D      W2     R22   Gn ______________________________________ Q5        H         COOMe  O      Me    Gc CH.sub.2 - Q5 H         COOMe  O      Me    G3 Q5        H         COOMe  O      Et    Gc Q5        H         COOMe  O      Prn   G3 Q26       H         COOMe  O      Me    Gc Q26       H         COOMe  O      Et    G3 Q61       H         COOMe  O      Me    Gc CH.sub.2 - Q61 H         COOMe  O      Me    G3 Q61       H         COOMe  O      Et    Gc Q61       H         COOMe  O      Prn   G3 Q158      H         COOMe  O      Me    Gc Q158      H         COOMe  O      Et    G3 Q5        H         COOMe  S      Me    Gc CH.sub.2 - Q5 H         COOMe  S      Me    G3 Q5        H         COOMe  S      Et    Gc Q5        H         COOMe  S      Prn   G3 Q26       H         COOMe  S      Me    Gc Q26       H         COOMe  S      Et    G3 Q61       H         COOMe  S      Me    Gc CH.sub.2 - Q61 H         COOMe  S      Me    G3 Q61       H         COOMe  S      Et    Gc Q61       H         COOMe  S      Prn   G3 Q158      H         COOMe  S      Me    Gc Q158      H         COOMe  S      Et    G3 Q5        H         COOEt  O      Me    Gc CH.sub.2 - Q5 H         COOEt  O      Me    G3 Q5        H         COOEt  O      Et    Gc Q5        H         COOEt  O      Prn   G3 Q26       H         COOEt  O      Me    Gc Q26       H         COOEt  O      Et    G3 Q61       H         COOEt  O      Me    Gc CH.sub.2 - Q61 H         COOEt  O      Me    G3 Q61       H         COOEt  O      Et    Gc Q61       H         COOEt  O      Prn   G3 Q158      H         COOEt  O      Me    Gc Q158      H         COOEt  O      Et    G3 Q5        H         COOEt  S      Me    Gc CH.sub.2 - Q5 H         COOEt  S      Me    G3 Q5        H         COOEt  S      Et    Gc Q5        H         COOEt  S      Prn   G3 Q26       H         COOEt  S      Me    Gc Q26       H         COOEt  S      Et    G3 Q61       H         COOEt  S      Me    Gc CH.sub.2 - Q61 H         COOEt  S      Me    G3 Q61       H         COOEt  S      Et    Gc Q61       H         COOEt  S      Prn   G3 Q158      H         COOEt  S      Me    Gc Q158      H         COOEt  S      Et    G3 Q201      H         COOMe  O      Me    Gc CH.sub.2 - Q201 H         COOMe  O      Me    G.sub.3 Q201      H         COOMe  O      Et    Gc Q201      H         COOMe  O      Prn   Gc Q205      H         COOMe  O      Me    Gc Q205      H         COOMe  O      Et    Gc Q222      H         COOMe  O      Me    Gc Q222      H         COOMe  O      Et    G.sub.3 Q229      H         COOMe  O      Me    G.sub.3 Q229      H         COOMe  O      Et    Gc Q201      H         COOMe  S      Me    Gc CH.sub.2 - Q201 H         COOMe  S      Me    G.sub.3 Q201      H         COOMe  S      Et    Gc Q201      H         COOMe  S      Prn   Gc Q205      H         COOMe  S      Me    Gc Q205      H         COOMe  S      Et    Gc Q222      H         COOMe  S      Me    Gc Q222      H         COOMe  S      Et    G.sub.3 Q229      H         COOMe  S      Me    Gc Q229      H         COOMe  S      Et    G.sub.3 Q201      H         COOEt  O      Me    Gc CH.sub.2 - Q201 H         COOEt  O      Me    G.sub.3 Q201      H         COOEt  O      Et    Gc Q201      H         COOEt  O      Prn   Gc Q205      H         COOEt  O      Me    Gc Q205      H         COOEt  O      Et    Gc Q222      H         COOEt  O      Me    Gc Q222      H         COOEt  O      Et    G.sub.3 Q229      H         COOEt  O      Me    Gc Q229      H         COOEt  O      Et    G.sub..sub.3 Q201      H         COOEt  S      Me    Gc CH.sub.2 - Q201 H         COOEt  S      Me    G.sub.3 Q201      H         COOEt  S      Et    Gc Q201      H         COOEt  S      Prn   Gc Q205      H         COOEt  S      Me    Gc Q205      H         COOEt  S      Et    G.sub.3 Q222      H         COOEt  S      Me    Gc Q222      H         COOEt  S      Et    Gc Q229      H         COOEt  S      Me    G.sub.1 Q229      H         COOEt  S      Et    G.sub.1 ______________________________________ ______________________________________ ##STR36## A         B       D         Az       Gn ______________________________________ Q5        H       COOMe     Imidazol-1-yl Gc Q5        H       COOMe     Pyrazol-1-yl Gc CH.sub.2 - Q5 H       COOMe     Imidazol-1-yl G.sub.1 CH.sub.2 - Q5 H       COOMe     Pyrazol-1-yl G.sub.1 Q26       H       COOMe     Imidazol-1-yl Gc Q26       H       COOMe     Pyrazol-1-yl Gc Q61       H       COOMe     Imidazol-1-yl Gc Q61       H       COOMe     Pyrazol-1-yl Gc CH.sub.2 - Q61 H       COOMe     Imidazol-1-yl G.sub.3 CH.sub.2 - Q61 H       COOMe     Pyrazol-1-yl G.sub.3 Q5        H       COOEt     Imidazol-1-yl Gc Q5        H       COOEt     Pyrazol-1-yl Gc CH.sub.2 - Q5 H       COOEt     Imidazol-1-yl G.sub.3 CH.sub.2 - Q5 H       COOEt     Pyrazol-1-yl G.sub.3 Q26       H       COOEt     Imidazol-1-yl Gc Q26       H       COOEt     Pyrazol-1-yl Gc Q61       H       COOEt     Imidazol-1-yl Gc Q61       H       COOEt     Pyrazol-1-yl Gc CH.sub.2 - Q61 H       COOEt     Imidazol-1-yl G.sub.3 CH.sub.2 - Q61 H       COOEt     Pyrazol-1-yl G.sub.3 Q201      H       COOMe     Imidazol-1-yl Gc Q201      H       COOMe     Pyrazol-1-yl Gc CH.sub.2 - Q201 H       COOMe     Imidazol-1-yl G.sub.1 CH.sub.2 - Q201 H       COOMe     Pyrazol-1-yl G.sub.1 Q205      H       COOMe     Imidazol-1-yl Gc Q205      H       COOMe     Pyrazol-1-yl Gc Q222      H       COOMe     Imidazol-1-yl Gc Q222      H       COOMe     Pyrazol-1-yl Gc Q229      H       COOMe     Imidazol-1-yl G.sub.3 Q229      H       COOMe     Pyrazol-1-yl G.sub.3 Q201      H       COOEt     Imidazol-1-yl Gc Q201      H       COOEt     Pyrazol-1-yl Gc CH.sub.2 - Q201 H       COOEt     Imidazol-1-yl G.sub.3 CH.sub.2 - Q201 H       COOEt     Pyrazol-1-yl G.sub.3 Q205      H       COOEt     Imidazol-1-yl Gc Q205      H       COOEt     Pyrazol-1-yl Gc Q222      H       COOEt     Imidazol-1-yl Gc Q222      H       COOEt     Pyrazol-1-yl Gc Q229      H       COOEt     Imidazol-1-yl G.sub.3 Q229      H       COOEt     Pyrazol-1-yl G.sub.3 ______________________________________ ______________________________________ ##STR37## A         B       D        J      R.sup.23 Gn ______________________________________ Q5        H       COOMe    Me     H    G3 Q5        H       COOMe    Me     Me   Gc Q5        H       COOMe    Me     OMe  Gc Q5        H       COOMe    Et     H    Gc Q5        H       COOMe    Et     Me   Gc Q5        H       COOMe    Et     OMe  G3 Q5        H       COOMe    J6     H    Gc Q5        H       COOMe    J6     Me   Gc Q5        H       COOMe    J6     OMe  G3 Q5        H       COOEt    Me     H    Gc Q5        H       COOEt    Me     Me   G3 Q5        H       COOEt    Me     OMe  Gc Q5        H       COOEt    Et     H    Gc Q5        H       COOEt    Et     Me   G3 Q5        H       COOEt    Et     OMe  Gc Q5        H       COOEt    J7     H    Gc Q5        H       COOEt    J7     Me   Gc Q5        H       COOEt    J7     OMe  Gc CH.sub.2 - Q5 H       COOMe    Me     H    G3 CH.sub.2 - Q5 H       COOEt    Me     OMe  Gc Q26       H       COOMe    Me     H    Gc Q26       H       COOEt    Me     OMe  Gc Q61       H       COOMe    Me     H    G3 Q61       H       COOMe    Me     Me   Gc Q61       H       COOMe    Me     OMe  Gc Q61       H       COOMe    Et     H    Gc Q61       H       COOMe    Et     Me   Gc Q61       H       COOMe    Et     OMe  G3 Q61       H       COOMe    J8     H    Gc Q61       H       COOMe    J8     Me   Gc Q61       H       COOMe    J8     OMe  G3 Q61       H       COOEt    Me     H    Gc Q61       H       COOEt    Me     Me   G3 Q61       H       COOEt    Me     OMe  Gc Q61       H       COOEt    Et     H    Gc Q61       H       COOEt    Et     Me   G3 Q61       H       COOEt    Et     OMe  Gc Q61       H       COOEt    J9     H    Gc Q61       H       COOEt    J9     Me   Gc Q61       H       COOEt    J9     OMe  Gc CH.sub.2 - Q61 H       COOMe    Me     H    G3 CH.sub.2 - Q61 H       COOEt    Me     OMe  Gc Q201      H       COOMe    Me     H    G.sub.3 Q201      H       COOMe    Me     Me   Gc Q201      H       COOMe    Me     OMe  Gc Q201      H       COOMe    Et     H    Gc Q201      H       COOMe    Et     Me   Gc Q201      H       COOMe    Et     OMe  G.sub.3 Q201      H       COOMe    J13    H    Gc Q201      H       COOMe    J13    Me   Gc Q201      H       COOMe    J13    OMe  G.sub.3 Q201      H       COOEt    Me     H    Gc Q201      H       COOEt    Me     Me   G.sub.3 Q201      H       COOEt    Me     OMe  Gc Q201      H       COOEt    Et     H    Gc Q201      H       COOEt    Et     Me   G.sub.3 Q201      H       COOEt    Et     OMe  Gc Q201      H       COOEt    J14    H    Gc Q201      H       COOEt    J14    Me   Gc Q201      H       COOEt    J14    OMe  Gc CH.sub.2 - Q201 H       COOMe    Me     H    G.sub.3 CH.sub.2 - Q201 H       COOEt    Me     OMe  Gc Q205      H       COOMe    Me     H    Gc Q205      H       COOEt    Me     OMe  Gc Q229      H       COOMe    Me     H    Gc Q229      H       COOEt    Me     OMe  G.sub.3 ______________________________________

In application of the compounds of this invention as herbicides, they can be applied by mixing with suitable carriers such as solid carriers, including for example clay, talc, bentonite, diatomaceous earth and others, or liquid carriers, including for example water, alcohols (methanol, ethanol and the like), aromatic hydrocarbons (benzene, toluene, xylene and the like), chlorinated hydrocarbons, ethers, ketones, esters (ethyl acetate etc.), acid amides (dimethylformamide etc.) and others. They can be provided for practical use with addition of any desired additive selected from an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader and a stabilizer and in any desired form such as a soluble concentrate, an emulsifiable concentrate, a wettable powder, a dust, a granule, a flowable, etc.

In the following, there are shown examples of formulations of herbicides containing the compounds of this invention as active ingredients, but they are not limitative of this invention. In the exemplary formulations shown below, "parts" means "parts by weight". Exemplary Formulation 1: Wettable powder ______________________________________ Compound No. 11 of this invention 20 parts Zeeklite A                  76 parts (kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.) Solpol 5039                  2 parts (mixture of nonionic surfactant and anionic surfac- tant; trade name; produced by Toho Kagaku Co., Ltd.) Carplex (anticaking agent)   2 parts (white carbon; trade name, produced by Shionogi Seiyaku Co., Ltd.) ______________________________________

The above components are mixed and pulverized homogeneously to prepare a wettable powder. Exemplary Formulation 2: Wettable powder ______________________________________ Compound No. 6 of this invention 40 parts Zeeklite A                  54 parts (kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.) Solpol 5039                  2 parts (mixture of nonionic surfactant and anionic surfac- tant; trade name; produced by Toho Kagaku Co., Ltd.) Carplex (anticaking agent)   4 parts (white carbon; trade name, produced by Shionogi Seiyaku Co., Ltd.) ______________________________________

The above components are mixed and pulverized homogeneously to prepare a wettable powder. Exemplary Formulation 3: Emulsifiable concentrate ______________________________________ Compound No. 3 of this invention 5 parts Xylene                      75 parts Dimethylformamide           15 parts Solpol 2680                  5 parts (mixture of nonionic surfactant and anionic surfac- tant; trade name; produced by Toho Kagaku Co., Ltd.) ______________________________________

The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted 10 to 10,000 times and sprayed in an amount of 0.005 to 10 kg per hectare in terms of the active ingredient. Exemplary Formulation 4: Flowable ______________________________________ Compound No. 11 of this invention 25     parts Agrisol S-710              10     parts (nonionic surfactant; trade name; produced by Kao Co., Ltd.) Runox 1000C                0.5    part (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) 1% Rhodopol water          20     parts (thickener; trade name, produced by Rhone-Poulenc Co., Ltd.) Water                      44.5   parts ______________________________________

The above components are mixed homogeneously to provide a flowable agent. Exemplary Formulation 5: Flowable ______________________________________ Compound No. 9 of this invention 40     parts Agrisol S-710              10     parts (nonionic surfactant; trade name; produced by Kao Co., Ltd.) Runox 1000C                0.5    part (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) 1% Rhodopol water          20     parts (thickener; trade name, produced by Rhone-Poulenc Co., Ltd.) Water                      29.5   parts ______________________________________

The above components are mixed homogeneously to provide a flowable agent. Exemplary Formulation 6: Granule ______________________________________ Compound No. 8 of this invention 1        part Bentonite             55       parts Talc                  44       parts ______________________________________

The above components are mixed and pulverized homogeneously, then a small amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule. Exemplary Formulation 7: Wettable powder ______________________________________ Compound No. 24 of this invention 20 parts Zeeklite A                  76 parts (kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.) Solpol 5039                  2 parts (mixture of nonionic surfactant and anionic surfac- tant; trade name; produced by Toho Kagaku Co., Ltd.) Carplex (anticaking agent)   2 parts (white carbon; trade name, produced by Shionogi Seiyaku Co., Ltd.) ______________________________________

The above components are mixed and pulverized homogeneously to prepare a wettable powder. Exemplary Formulation 8: Wettable powder ______________________________________ Compound No. 21 of this invention 40 parts Zeeklite A                  54 parts (kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.) Solpol 5039                  2 parts (mixture of nonionic surfactant and anionic surfac- tant; trade name; produced by Toho Kagaku Co., Ltd.) Carplex (anticaking agent)   4 parts (white carbon; trade name, produced by Shionogi Seiyaku Co., Ltd.) ______________________________________

The above components are mixed and pulverized homogeneously to prepare a wettable powder. Exemplary Formulation 9: Emulsifiable concentrate ______________________________________ Compound No. 22 of this invention 5 parts Xylene                      75 parts Dimethylformamide           15 parts Solpol 2680                  5 parts (mixture of nonionic surfactant and anionic surfac- tant; trade name; produced by Toho Kagaku Co., Ltd.) ______________________________________

The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted 10 to 10,000 times and sprayed in an amount of 0.005 to 10 kg per hectare in terms of the active ingredient. Exemplary Formulation 10: Flowable ______________________________________ Compound No. 24 of this invention 25     parts Agrisol S-710              10     parts (nonionic surfactant; trade name; produced by Kao Co., Ltd.) Runox 1000C                0.5    part (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) 1% Rhodopol water          20     parts (thickener; trade name, produced by Rhone-Poulenc Co., Ltd.) Water                      44.5   parts ______________________________________

The above components are mixed homogeneously to provide a flowable agent. Exemplary Formulation 11: Flowable ______________________________________ Compound No. 21 of this invention 40     parts Agrisol S-710              10     parts (nonionic surfactant; trade name; produced by Kao Co., Ltd.) Runox 1000C                0.5    part (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) 1% Rhodopol water          20     parts (thickener; trade name, produced by Rhone-Poulenc Co., Ltd.) Water                      29.5   parts ______________________________________

The above components are mixed homogeneously to provide a flowable agent. Exemplary Formulation 12: Granule ______________________________________ Compound No. 23 of this invention 1        part Bentonite             55       parts Talc                  44       parts ______________________________________

The above components are mixed and pulverized homogeneously, then a small amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

If desired, the compound of this invention may be applied as a mixture with other kinds of herbicides, various insecticides, sterilizers or adjuvants during preparation or before spraying.

Such other kinds of herbicides as mentioned above include compounds as described in Farm Chemicals Handbook (1986).

The compounds of this invention can also be applied not only to the agricultural and horticultural fields such as farm fields, paddy fields, fruit gardens and the like, but to the non-agricultural fields such as athletic grounds, vacant lands, belts along railroads and others in order to prevent and eliminate various weeds. The amounts of the herbicide to be applied, which may differ depending on the scenes to be applied, the time of application, the application method, the kinds of the objective grasses and the crops harvested, may generally range suitably from about 0.005 to 10 kg per hectare in terms of the active ingredient.

The following test examples are set forth for illustrating specifically the effectiveness of the compounds of this invention as herbicides.

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (A) barnyardgrass (Echinochloa crusgalli), (B) large crabgrass (Digitaria adscendens), (C) annual sedge (Cyperus microiria), (D) black nightshade (Solanum nigrum L.), (E) hairly galinosoga (Galinosoga ciliata), (F) yellows cress (Rorippa atrovirens), (G) rice (Oryza sativa), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp) and (L) sugar beet (Beta vulgaris) were sown mixedly. After covering the seeds with soil to about 1.5 cm, herbicides were sprayed evenly on the soil surface respectively such that a predetermined proportion of the active ingredient may be applied.

In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops and each of the weeds were examined according to the judgment criteria shown below. Provided that, in the following Table, a mark "-" was shown in the column of activity when beet was omitted from the crops to be tested.

The results are shown in Table 16.

Some of the compounds of this invention show the selectivity on certain crops. Judgment criteria: ______________________________________ 5 . . .  Growth control rates of more than 90% (almost completely withered) 4 . . .  Growth control rates of 70 to 90% 3 . . .  Growth control rates of 40 to 70% 2 . . .  Growth control rates of 20 to 40% 1 . . .  Growth control rates of 5 to 20% 0 . . .  Growth control rates of less than 5% (substantially no effect) ______________________________________

The above growth control rates are determined by measuring the top fresh weights of the treated plants and those of the non-treated plants, and calculated from the following formula: ##EQU1## __________________________________________________________________________ Amount of ac- tive ingredi- Compound ent applied No.   kg/ha   (A) (B) (C) (D) (E) (F) (G) (H) (I) (J) (K) (L) __________________________________________________________________________ 3    0.32    5  4  5  4  4  5  5  5  5  5  0  -- 6    0.32    5  5  5  5  5  5  5  5  5  5  0  -- 9    0.16    5  5  5  5  5  5  5  5  5  5  0  -- 0.32    5  5  5  5  5  5  5  5  5  5  0  -- 11    0.08    5  5  5  5  5  5  5  5  5  5  5  0 0.16    5  5  5  5  5  5  5  5  5  5  5  0 13    0.16    5  5  5  5  5  5  5  5  5  5  5  0 16    0.08    5  3  5  5  5  5  5  5  3  3  0  0 0.16    5  4  5  5  5  5  5  5  4  4  1  0 19    0.04    4  3  5  5  5  5  5  5  5  5  5  -- 0.08    5  4  5  5  5  5  5  5  5  5  5  -- 0.16    5  5  5  5  5  5  5  5  5  5  5  -- 21    0.04    4  4  4  4  5  5  5  4  0  4  0  -- 0.08    5  5  5  5  5  5  5  5  1  5  0  -- 0.16    5  5  5  5  5  5  5  5  2  5  1  -- 24    0.02    5  4  5  5  5  5  5  5  5  5  0  -- 0.04    5  5  5  5  5  5  5  5  5  5  0  -- 0.08    5  5  5  5  5  5  5  5  5  5  0  -- __________________________________________________________________________ (A) barnyardgrass (Echinochloa crusgalli), (B) large crabgrass (Digitaria adscendens), (C) annual sedge (Cyperus microiria), (D) black nightshade (Solanum nigrum L.), (E) hairly galinosoga (Galinosoga ciliata), (F) yellows cress (Rorippa atrovirens), (G) rice (Oryza sativa), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp), (L) sugar beet (Beta vulgaris).

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (A) barnyardgrass (Echinochloa crusgalli), (B) large crabgrass (Digitaria adscendens), (C) annual sedge (Cyperus microiria), (D) black nightshade (Solanum nigrum L.), (E) hairly galinosoga (Galinosoga ciliata), (F) yellows cress (Rorippa atrovirens), (G) rice (Oryza sativa), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp) and (L) sugar beet (Beta vulgaris) were sown in spots. After covering the seeds with soil to about 1.5 cm, herbicides were sprayed evenly on the soil surface such that a predetermined proportion of the active ingredient may be applied.

In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface of the foliage portions of each crop and weed by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops etc. and each of the weeds were examined according to the judgment criteria shown in Test Example 1.

The results are shown in Table 17. __________________________________________________________________________ Amount of ac- tive ingredi- Compound ent applied No.   kg/ha   (A) (B) (C) (D) (E) (F) (G) (H) (I) (J) (K) (L) __________________________________________________________________________ 3    0.08    5  2  5  5  5  5  5  5  5  5  0  5 0.16    5  3  5  5  5  5  5  5  5  5  1  5 5    0.32    5  5  5  5  5  5  5  5  5  5  5  -- 6    0.04    5  1  4  5  5  5  5  5  0  5  5  5 0.08    5  2  5  5  5  5  5  5  1  5  5  5 0.16    5  3  5  5  5  5  5  5  2  5  5  5 8    0.08    4  1  5  5  5  5  5  4  0  5  4  5 0.16    5  2  5  5  5  5  5  5  0  5  5  5 9    0.04    5  3  4  5  5  5  5  5  4  5  5  5 0.08    5  4  5  5  5  5  5  5  5  5  5  5 0.16    5  5  5  5  5  5  5  5  5  5  5  5 11    0.04    5  4  5  5  5  5  5  5  5  5  5  0 0.08    5  5  5  5  5  5  5  5  5  5  5  0 0.16    5  5  5  5  5  5  5  5  5  5  5  0 13    0.16    5  5  5  5  5  5  5  5  5  5  5  0 16    0.08    5  4  5  5  5  5  5  5  5  5  5  0 0.16    5  5  5  5  5  5  5  5  5  5  5  0 19    0.04    5  4  5  5  5  5  5  5  5  5  5  5 0.08    5  5  5  5  5  5  5  5  5  5  5  5 0.16    5  5  5  5  5  5  5  5  5  5  5  5 21    0.02    3  2  5  5  5  5  5  5  4  5  4  5 0.04    4  3  5  5  5  5  5  5  5  5  5  5 0.08    5  4  5  5  5  5  5  5  5  5  5  5 24    0.01    5  4  5  5  5  5  5  5  4  5  4  5 0.02    5  5  5  5  5  5  5  5  5  5  5  5 0.04    5  5  5  5  5  5  5  5  5  5  5  5 __________________________________________________________________________ (A) barnyardgrass (Echinochloa crusgalli), (B) large crabgrass (Digitaria adscendens), (C) annual sedge (Cyperus microiria), (D) black nightshade (Solanum nigrum L.), (E) hairly galinosoga (Galinosoga ciliata), (F) yellows cress (Rorippa atrovirens), (G) rice (Oryza sativa), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp), (L) sugar beet (Beta vulgaris).

## Claims

1. An imidazolesulfonamide derivative represented by the formula (I): ##STR38## wherein Q represents a group of: ##STR39## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a halogenated lower alkyl group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a group of NR.sup.12 R.sup.13, a lower alkoxy group, a group of SO.sub.2 NR.sup.8 R.sup.9, a group of SO.sub.2 OR.sup.11 or a phenyl group which may be substituted by a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group or a lower alkyl group; atom, a lower alkyl group, a halogenated lower alkyl group, a nitro group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a lower alkoxy group or a phenyl group which may be substituted by a halogen atom, a group of COOR.sup.10, a nitro group, a lower alkoxy group or a lower alkyl group; atom, a lower alkyl group, a lower alkoxy group, a nitro group or a group of COOR.sup.10 ; alkyl group or a phenyl group; ; or 2; and lower alkyl group; nitro group, a lower alkyl group, a lower aralkyl group, a lower alkoxy group, a halogenated lower alkyl group, a halogenated lower alkenyl group, a lower alkoxyalkyl group, an alkylcarbonyl group, a group of COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of OH, a benzoyl group which may be substituted by a halogen atom or a lower alkyl group or a phenyl group which may substituted by is selected from a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group or a lower alkyl group; substituted by a group of OR.sup.10, a halogen atom, a halogenated lower alkoxy group, a cyano group, a phenoxy group, a lower alkoxycarbonyl group, a group of NR.sup.10 R.sup.11, a lower cycloalkyl group, a lower alkylthio group or a lower alkylcarbonyl group, a lower alkenyl group, a halogenated lower alkenyl group, a lower alkynyl group, a halogenated lower alkynyl group, a lower cycloalkyl group or a benzyl group; and R.sup.16 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; group, a halogenated alkyl group, a lower alkenyloxy group or a lower alkynyloxy group; and n represents an integer of 0, 1 or 2; alkyl group, a lower alkylcarbonyl group or a lower alkylsulfonyl group; alkyl group, a lower alkenyl group or a lower alkynyl group; ##STR40## E represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower alkoxy group; ##STR41## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkoxyalkyl group, a halogenated alkyl group, a halogenated lower alkoxy group, a group of NR.sup.24 R.sup.25, a group of OCH(R.sup.10)--COOR.sup.10, a group of COOR.sup.10, a cyclopropyl group, a group of CH(OR.sup.26).sub.2, a lower alkylthio group or a halogenated lower alkylthio group; alkyl group or a lower alkoxy group; atom, a lower alkyl group, a halogenated alkyl group or a lower alkoxy group; lower alkyl group, a halogen atom, a lower alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ; R.sup.28 represents a hydrogen atom or a lower alkoxy group; imidazolynyl group, a pyrazolyl group, a triazolyl group or a benzimidazolyl group each of which may be mono-, di- or tri-substituted by a lower alkyl group; ##STR42## wherein Q, R, m, B and D have the same meanings as defined above; R.sup.23 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group.

2. The compound of claim 1, which is represented by the formula: ##STR43## wherein R.sub.1 represents a hydrogen atom, a methyl group or a halogen atom; R represents a methyl group or an ethyl group; Q is selected from the group of Q5, Q6, Q7, Q9, Q15, Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68, Q88, Q127, Q138, Q142, Q188, Q189, Q201, Q202, Q204, Q205, Q209, Q222, Q225, Q229, Q230, Q246 and Q250 as shown below: ##STR44## X and Y are each independently a halogen atom, a methyl group, a methoxy group; and Z is --CH.dbd..

3. The compound of claim 2, which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-thiaz olyl)imidazole-5-sulfonamide.

4. The compound of claim 2, which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-thia zolyl)imidazole-5-sulfonamide.

5. The compound of claim 2, which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(1,3,4- thiadiazol-2-yl)imidazole-5-sulfonamide.

6. The compound of claim 2, which is N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyrid yl)imidazole-5-sulfonamide.

7. The compound of claim 2, which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyri midyl)imidazole-5-sulfonamide.

8. The compound of claim 1, which is represented by the formula: ##STR45## wherein R.sub.1 represents a hydrogen atom or a methyl group; R represents a methyl group or an ethyl group; Q is selected from the group of Q5, Q6, Q7, Q9, Q15, Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68, Q88, Q127, Q138, Q142, Q188, Q189, Q201, Q202, Q204, Q205, Q209, Q222, Q225, Q229, Q230, Q246 and Q250 as shown below: ##STR46## X and Y are each independently a halogen atom, a methyl group, a methoxy group; and Z is --CH.dbd..

9. The compound of claim 1, which is represented by the formula: ##STR47## wherein R.sub.1 represents a hydrogen atom, a methyl group, a halogen atom or a nitro group; R represents a methyl group or an ethyl group; Q is selected from the group of Q5, Q6, Q7, Q9, Q15, Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68, Q88, Q127, Q138, Q142, Q188, Q189, Q201, Q202, Q204, Q205, Q209, Q222, Q225, Q229, Q230, Q246 and Q250 as shown below: ##STR48## X and Y are each independently a halogen atom, a methyl group, a methoxy group; and Z is --CH.dbd..

10. The compound of claim 2, which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-pyrid yl)imidazole-5-sulfonamide.

11. The compound of claim 2, which is the compound where R is an ethyl group, R.sub.1 is a hydrogen atom and Q is Q204.

12. The compound of claim 11, wherein X and Y are each independently selected from methyl and methoxy.

13. The compound of claim 12, wherein X and Y are each methoxy.

14. The compound of claim 2, which is the compound where R is an ethyl group, R.sub.1 is a hydrogen atom and Q is Q222.

15. The compound of claim 14, wherein X and Y are each independently selected from methyl and methoxy.

16. The compound of claim 15, wherein X and Y are each methoxy.

17. The compound of claim 1, wherein G is ##STR49##

18. A method for inhibiting growth of undesirable plants by using the compound represented by the formula (I): ##STR50## wherein Q represents a group of: ##STR51## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a halogenated lower alkyl group, group of NR.sup.12 R.sup.13, a lower alkoxy group, a group of SO.sub.2 NR.sup.8 R.sup.9, a group of SO.sub.2 OR.sup.11 or a phenyl group which may be substituted by a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group or a lower alkyl group; atom, a lower alkyl group, a halogenated lower alkyl group, a nitro group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a lower alkoxy group or a phenyl group which may be substituted by a halogen atom, a group of COOR.sup.10, a nitro group, a lower alkoxy group or a lower alkyl group; atom, a lower alkyl group, a lower alkoxy group, a nitro group or a group of COOR.sup.10 ; alkyl group or a phenyl group; ; or 2; and lower alkyl group; nitro group, a lower alkyl group, a lower aralkyl group, a lower alkoxy group, a halogenated lower alkyl group, a halogenated lower alkenyl group, a lower alkoxyalkyl group, an alkylcarbonyl group, a group of COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of OH, a benzoyl group which may be substituted by a halogen atom or a lower alkyl group or a phenyl group which may substituted by is selected from a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group or a lower alkyl group; substituted by a group of OR.sup.10, a halogen atom, a halogenated lower alkoxy group, a cyano group, a phenoxy group, a lower alkoxycarbonyl group, a group of NR.sup.10 R.sup.11, a lower cycloalkyl group, a lower alkylthio group or a lower alkylcarbonyl group, a lower alkenyl group, a halogenated lower alkenyl group, a lower alkynyl group, a halogenated lower alkynyl group, a lower cycloalkyl group or a benzyl group; and R.sup.16 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; group, a halogenated alkyl group, a lower alkenyloxy group or a lower alkynyloxy group; and n represents an integer of 0, 1 or 2; alkyl group, a lower alkylcarbonyl group or a lower alkylsulfonyl group; alkyl group, a lower alkenyl group or a lower alkynyl group; ##STR52## E represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower alkoxy group; ##STR53## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkoxyalkyl group, a halogenated alkyl group, a halogenated lower alkoxy group, a group of NR.sup.24 R.sup.25, a group of OCH(R.sup.10)--COOR.sup.10, a group of COOR.sup.10, a cyclopropyl group, a group of CH(OR.sup.26).sub.2, a lower alkylthio group or a halogenated lower alkylthio group; alkyl group or a lower alkoxy group; atom, a lower alkyl group; a halogenated alkyl group or a lower alkoxy group; lower alkyl group, a halogen atom, a lower alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ; R.sup.28 represents a hydrogen atom or a lower alkoxy group; imidazolynyl group, a pyrazolyl group, a triazolyl group or a benzimidazolyl group each of which may be mono-, di- or tri-substituted by a lower alkyl group; ##STR54## wherein Q, R, m, B and D have the same meanings as defined above; R.sup.23 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group.

19. The method of claim 18, wherein G is ##STR55##

20. A herbicide which comprises a herbicidal carrier and as an effective ingredient, a compound represented by the formula (I): ##STR56## wherein Q represents a group of; ##STR57## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a halogenated lower alkyl group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a group of NR.sup.12 R.sup.13, a lower alkoxy group, a group of SO.sub.2 NR.sup.8 R.sup.9, a group of SO.sub.2 OR.sup.11 or a phenyl group which may be substituted by a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group or a lower alkyl group; atom, a lower alkyl group, a halogenated lower alkyl group, a nitro group, a cyano group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a lower alkoxy group or a phenyl group which may be substituted by a halogen atom, a group of COOR.sup.10, a nitro group, a lower alkoxy group or a lower alkyl group; atom, a lower alkyl group, a lower alkoxy group, a nitro group or a group of COOR.sup.10 ; alkyl group or a phenyl group; ; or 2; and lower alkyl group; nitro group, a lower alkyl group, a lower aralkyl group, a lower alkoxy group, a halogenated lower alkyl group, a halogenated lower alkenyl group, a lower alkoxyalkyl group, an alkylcarbonyl group, a group of COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of OH, a benzoyl group which may be substituted by a halogen atom or a lower alkyl group or a phenyl group which may substituted by is selected from a halogen atom, a nitro group, a group of COOR.sup.10, a lower alkoxy group or a lower alkyl group; substituted by a group of OR.sup.10, a halogen atom, a halogenated lower alkoxy group, a cyano group, a phenoxy group, a lower alkoxycarbonyl group, a group of NR.sup.10 R.sup.11, a lower cycloalkyl group, a lower alkylthio group or a lower alkylcarbonyl group, a lower alkenyl group, a halogenated lower alkenyl group, a lower alkynyl group, a halogenated lower alkynyl group, a lower cycloalkyl group or a benzyl group; and R.sup.16 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; group, a halogenated alkyl group, a lower alkenyloxy group or a lower alkynyloxy group; and n represents an integer of 0, 1 or 2; alkyl group, a lower alkylcarbonyl group or a lower alkylsulfonyl group; alkyl group, a lower alkenyl group or a lower alkynyl group; ##STR58## E represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower alkoxy group; ##STR59## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkoxyalkyl group, a halogenated alkyl group, a halogenated lower alkoxy group, a group of NR.sup.24 R.sup.25, a group of OCH(R.sup.10)--COOR.sup.10, a group of COOR.sup.10, a cyclopropyl group, a group of CH(OR.sup.26).sub.2, a lower alkylthio group or a halogenated lower alkylthio group; alkyl group or a lower alkoxy group; atom, a lower alkyl group, a halogenated alkyl group or a lower alkoxy group; lower alkyl group, a halogen atom, a lower alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ; R.sup.28 represents a hydrogen atom or a lower alkoxy group; imidazolynyl group, a pyrazolyl group, a triazolyl group or a benzimidazolyl group each of which may be mono-, di- or tri-substituted by a lower alkyl group; ##STR60## wherein Q, R, m, B and D have the same meanings as defined above; R.sup.23 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group.

21. The herbicide of claim 20, wherein G is ##STR61##