2 milligrams of 

powder next to 

a penny.

Carfentanil: A Dangerous New Factor in the U.S. Opioid Crisis

Carfentanil is a synthetic opioid approximately 10,000 times more potent than morphine and 100 times 

more potent than fentanyl. The presence of carfentanil in illicit U.S. drug markets is cause for concern, as 

the relative strength of this drug could lead to an increase in overdoses and overdose-related deaths, even 

among opioid-tolerant users. The presence of carfentanil poses a significant threat to first responders and 

law enforcement personnel who may come in contact with this substance. In any situation where any

fentanyl-related substance, such as carfentanil, might be present, law enforcement should 

carefully follow safety protocols to avoid accidental exposure.

Officer & Public Safety Information

 

Carfentanil and other fentanyl analogues present a serious risk to public safety, first responder, medical, 

treatment, and laboratory personnel. These substances can come in several forms, including powder, 

blotter paper, tablets, patch, and spray. Some forms can be absorbed through the skin or accidentally 

inhaled. If encountered, responding personnel should do the following based on the specific situation:

 Exercise extreme caution. Only properly trained and outfitted law enforcement professionals 

should handle any substance suspected to contain fentanyl or a fentanyl-related compound. If 

encountered, contact the appropriate officials within your agency.

 Be aware of any sign of exposure. Symptoms include: respiratory depression or arrest, 

drowsiness, disorientation, sedation, pinpoint pupils, and clammy skin. The onset of these symptoms 

usually occurs within minutes of exposure.

 Seek IMMEDIATE medical attention. Carfentanil and other fentanyl-related substances can work 

very quickly, so in cases of suspected exposure, it is important to call EMS immediately. If inhaled, 

move the victim to fresh air. If ingested and the victim is conscious, wash out the victim’s eyes and 

mouth with cool water.

 Be ready to administer naloxone in the event of exposure. Naloxone is an antidote for opioid

overdose. Immediately administering naloxone can reverse an overdose of carfentanil, fentanyl, or 

other opioids, although multiple doses of naloxone may be required. Continue to administer a dose 

of naloxone every 2-3 minutes until the individual is breathing on his/her own for at least 15 minutes 

or until EMS arrives.

 Remember that carfentanil can resemble powdered cocaine or heroin. If you suspect the 

presence of carfentanil or any synthetic opioid, do not take samples or otherwise disturb the 

substance, as this could lead to accidental exposure. Rather, secure the substance and follow 

approved transportation procedures.

Lethality:

Carfentanil is used as a tranquilizing agent for elephants and other large mammals. The 

lethal dose range for carfentanil in humans is unknown; however, carfentanil is 

approximately 100 times more potent than fentanyl, which can be lethal at the 2-

milligram range (photograph), depending on route of administration and other factors.

For additional safety information, please use the resources below:

 CDC Health Advisory (#CDCHAN-00384); http://emergency.cdc.gov/han/han00384.asp

 CDC Health Update (#CDCHAN-00395); http://emergency.cdc.gov/han/han00395.asp

 DEA Fentanyl Warning Video;https://www.dea.gov/video_clips/Fentanyl%20Roll%20Call%20Video.mp4