EXHIBIT
      4.12




**AMENDMENT
      No. 1**


**To**


**MDWERKS,
      INC.**


**FIRST
      AMENDED AND RESTATED SENIOR SECURED**


**CONVERTIBLE
      NOTE**







This
      AMENDMENT No. 1 to the MDwerks, Inc. First Amended and Restated Senior Secured
      Convertible Note, dated September 28, 2007 (this “ Amendment ”)
      is
      dated as of March 1, 2008, by and between MDWERKS, INC., a Delaware corporation
      (the “ Company ”),
      and
      GOTTBETTER CAPITAL MASTER, LTD. (IN LIQUIDATION), a Cayman Islands company
      (the
“ Consenting
      Holder ”).





WITNESSETH





WHEREAS,
      pursuant to a Securities Purchase Agreement, dated as of November 9, 2006 (as
      amended, the “ Securities
      Purchase Agreement ”),
      the
      Consenting Holder purchased a Senior Secured Convertible Note in the original
      principal amount of $2,500,000 (the “Original Note”);





WHEREAS,
      on September 28, 2007 the Company issued to the Consenting Holder the First
      Amended and Restated Senior Secured Convertible Note (as amended, or as amended
      and restated, from time to time, the “Note”) and the Original Note was
      cancelled;





WHEREAS,
      the Company and the Consenting Holder wish to extend the maturity date of the
      Note from November 9, 2009 to January 1, 2011 and to amend the Installment
      Schedule attached to the Note as Schedule I;





WHEREAS,
      defined terms used herein but not otherwise defined herein shall have the
      respective meanings ascribed to such terms in the Note;





NOW,
      THEREFORE, in consideration of the mutual promises of the parties hereto and
      of
      the mutual benefits to be gained by the performance thereof, and for other
      good
      and valuable consideration, the receipt and sufficiency of which are hereby
      acknowledge, the parties hereto hereby agree as follows:








1.  Section
      1
      of the Note is hereby deleted and is replaced in its entirety with the
      following:





“
1. PAYMENTS
      OF PRINCIPAL; MATURITY .
      On each
      Installment Date commencing March 1, 2008, the Company shall pay to the Holder
      an amount equal to the Installment Amount due on such Installment Date in cash
      by wire transfer of immediately available funds. Installment Dates and
      Installment Amounts are as set forth on the Installment Schedule. The **“Maturity
      Date”** shall be
      January 1, 2011, as may be extended at the option of the Holder (i) in the
      event
      that, and for so long as, an Event of Default (as defined in Section 4(a))
      shall
      have occurred and be continuing and (ii) through the date that is ten (10)
      days
      after the consummation of a Change of Control in the event that a Change of
      Control is publicly announced or a Change of Control Notice (as defined in
      Section 5(b)) is delivered prior to the Maturity Date.”










2.  The Installment
      Schedule attached to the Note as Schedule I is hereby deleted and replaced
      in
      its entirety with the Installment Schedule dated as of the date hereof and
      attached to this Amendment as Exhibit A.





3.  Notwithstanding
      anything to the contrary contained herein, if the Company does not obtain
      additional funding in the amount of at least five million dollars ($5,000,000)
      on or before March 31, 2008, this Amendment shall be void and of no force and
      effect; provided , however ,
      that
      the Consenting Party shall be deemed to have granted its consent to extend
      the
      February 1, 2008 and the March 1, 2008 Installment Dates set forth in the
      Original Note, until April 1, 2008.





4.  The
      Company hereby confirms that upon the closing of a financing to be provided
      by
      Vicis Capital Master Fund, or one of its affiliates, in the amount of not less
      than five million dollars ($5,000,000), the Company shall issue to the
      Consenting Party a warrant to purchase two million (2,000,000) shares of common
      stock of the Company at an exercise price equal to the lowest exercise or
      conversion price of any warrants, options or convertible securities issued
      to
      Vicis Capital Master fund in connection with such financing.




5.  This
      Amendment shall be construed and enforced in accordance with the laws of the
      State of New York.





6.  This
      Amendment may be executed in two or more counterparts, all of which shall
      together constitute a single agreement. A facsimile of an executed counterpart
      signature page shall be deemed to constitute an original executed counterpart
      signature page.





[SIGNATURE
      PAGE TO IMMEDIATELY FOLLOW THIS PAGE]








IN
      WITNESS WHEREOF, the parties hereto have duly executed this Amendment, Consent
      and Waiver as of the day and year first above written.




MDWERKS,
              INC.By:
            /s/ 
Howard
              B. KatzName:Howard
              B. KatzTitle:  
              Chief
              Executive Officer




GOTTBETTER
                CAPITAL MASTER,
                LTD.
              (IN
                LIQUIDATION)By:
            /s/ Stuart
              SybersmaName:Stuart
              SybersmaTitle:  
              Liquidator







**EXHIBIT
      A**




**SCHEDULE
      I**





**INSTALLMENT
      SCHEDULE**


AS
      OF
      MARCH 1, 2008


**Issue
                  Date**
              
              **11/9/2006****Face
                  Amount**
              
              **$2,500,000****Interest
                  Rate**
              
              **8.0%****Term
                  (months)**
              
              **49****Principal
                  (months)**
              
              **35****Period**
              **Installment**
                **Date**
              **Beginning****Principal**
              **Accrued****Interest**
              **Interest****Due**
              **Installment****Payment**
              **Ending****Principal**0
              12/1/2006
              2,500,000.00
              11,666.67
              11,666.67
              0.00
              2,500,000.001
              1/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.002
              2/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.003
              3/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.004
              4/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.005
              5/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.006
              6/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.007
              7/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.008
              8/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.009
              9/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.0010
              10/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.0011
              11/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.0012
              12/1/2007
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.0013
              1/1/2008
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.0014
              2/1/2008
              2,500,000.00
              16,666.67
              16,666.67
              0.00
              2,500,000.0015
              3/1/2008
              2,500,000.00
              16,666.67
              16,666.67
              138,888.89
              2,361,111.1116
              4/1/2008
              2,361,111.11
              15,740.74
              15,740.74
              69,444.44
              2,291,666.6717
              5/1/2008
              2,291,666.67
              15,277.78
              15,277.78
              69,444.44
              2,222,222.2218
              6/1/2008
              2,222,222.22
              14,814.81
              14,814.81
              69,444.44
              2,152,777.7819
              7/1/2008
              2,152,777.78
              14,351.85
              14,351.85
              69,444.44
              2,083,333.3320
              8/1/2008
              2,083,333.33
              13,888.89
              13,888.89
              69,444.44
              2,013,888.8921
              9/1/2008
              2,013,888.89
              13,425.93
              13,425.93
              69,444.44
              1,944,444.4422
              10/1/2008
              1,944,444.44
              12,962.96
              12,962.96
              69,444.44
              1,875,000.0023
              11/1/2008
              1,875,000.00
              12,500.00
              12,500.00
              69,444.44
              1,805,555.5624
              12/1/2008
              1,805,555.56
              12,037.04
              12,037.04
              69,444.44
              1,736,111.1125
              1/1/2009
              1,736,111.11
              11,574.07
              11,574.07
              69,444.44
              1,666,666.6726
              2/1/2009
              1,666,666.67
              11,111.11
              11,111.11
              69,444.44
              1,597,222.22
  
  **Period**
              **Installment**
                **Date**
              **Beginning****Principal**
              **Accrued****Interest**
              **Interest****Due**
              **Installment****Payment**
              **Ending****Principal**27
              3/1/2009
              1,597,222.22
              10,648.15
              10,648.15
              69,444.44
              1,527,777.7828
              4/1/2009
              1,527,777.78
              10,185.19
              10,185.19
              69,444.44
              1,458,333.3329
              5/1/2009
              1,458,333.33
              9,722.22
              9,722.22
              69,444.44
              1,388,888.8930
              6/1/2009
              1,388,888.89
              9,259.26
              9,259.26
              69,444.44
              1,319,444.4431
              7/1/2009
              1,319,444.44
              8,796.30
              8,796.30
              69,444.44
              1,250,000.0032
              8/1/2009
              1,250,000.00
              8,333.33
              8,333.33
              69,444.44
              1,180,555.5633
              9/1/2009
              1,180,555.56
              7,870.37
              7,870.37
              69,444.44
              1,111,111.1134
              10/1/2009
              1,111,111.11
              7,407.41
              7,407.41
              69,444.44
              1,041,666.6735
              11/1/2009
              1,041,666.67
              6,944.44
              6,944.44
              69,444.44
              972,222.2236
              12/1/2009
              972,222.22
              6,481.48
              6,481.48
              69,444.44
              902,777.7837
              1/1/2010
              902,777.78
              6,018.52
              6,018.52
              69,444.44
              833,333.3338
              2/1/2010
              833,333.33
              5,555.56
              5,555.56
              69,444.44
              763,888.8939
              3/1/2010
              763,888.89
              5,092.59
              5,092.59
              69,444.44
              694,444.4440
              4/1/2010
              694,444.44
              4,629.63
              4,629.63
              69,444.44
              625,000.0041
              5/1/2010
              625,000.00
              4,166.67
              4,166.67
              69,444.44
              555,555.5642
              6/1/2010
              555,555.56
              3,703.70
              3,703.70
              69,444.44
              486,111.1143
              7/1/2010
              486,111.11
              3,240.74
              3,240.74
              69,444.44
              416,666.6744
              8/1/2010
              416,666.67
              2,777.78
              2,777.78
              69,444.44
              347,222.2245
              9/1/2010
              347,222.22
              2,314.81
              2,314.81
              69,444.44
              277,777.7846
              10/1/2010
              277,777.78
              1,851.85
              1,851.85
              69,444.44
              208,333.3347
              11/1/2010
              208,333.33
              1,388.89
              1,388.89
              69,444.44
              138,888.8948
              12/1/2010
              138,888.89
              925.93
              925.93
              69,444.44
              69,444.4449
              1/1/2011
              69,444.44
              462.96
              462.96
              69,444.44
              0.00