77426 Federal Register / Vol. 85, No. 232 / Wednesday, December 2, 2020 / Notices 

3See the following studies for leaderless FMD 

virus safety data: Uddowla S., et al. A Safe Footand-Mouth Disease Vaccine Platform with Two 

Negative Markers for Differentiating Infected from 

Vaccinated Animals. Journal of Virology Oct 2012, 

86(21) 11675–11685: DOI: 10.1128/JVI.01254–12; 

Eschbaumer M., et al. Foot-and-mouth disease virus 

lacking the leader 2 protein and containing two 

negative DIVA markers 3 (FMDV LL3B3D A24) is 

fully attenuated in pigs. Pathogens. (2020) 17:1–8: 

DOI: 10.3390/pathogens9020129; Hardham, John 

M., et al., Novel Foot-and-Mouth Disease Vaccine 

Platform: Formulations for Safe and DIVACompatible FMD Vaccines with Improved Potency. 

Frontiers in Veterinary Science, 25 September 2020; 

https://doi.org/10.3389/fvets.2020.554305. 

4 In a 2018 meeting report drafted by the Global 

Foot-and-Moth Disease Research Alliance that 

reviewed FMD vaccine platforms, the FMDLL3B3D 

platform received the highest score. Global Footand-Mouth Disease Research Alliance, Gap 

Analysis Report. December 2018: https://

go.usa.gov/xdrKh. 

In addition to the risk assessment 

summary, we wish to provide the 

following information regarding our 

evaluation. 

Development and Safety of the FMD– 

LL3B3D Leaderless FMD Virus 

The FMD–LL3B3D leaderless vaccine 

platform virus was created by deleting 

the leader (L) and one of three 3B 

genetic sequences of the FMD virus (L 

is a part of the virus that determines 

virulence), resulting in an attenuated 

virus that is innocuous for cattle and 

pigs but capable of growing in cell 

culture.3 As a result, if the FMD– 

LL3B3D leaderless virus were to escape 

a manufacturing facility, it would be 

incapable of causing FMD in any 

animals exposed to it, nor could such 

animals spread the virus to other 

animals. In contrast, the risk of escape 

from facilities using traditionally 

virulent FMD viruses to manufacture 

vaccine is why many countries restrict 

FMD vaccine production to only local 

endemic strains. The deletion of L and 

the relevant 3B genetic sequence was 

therefore a key consideration in our 

evaluation. 

Of similar importance was our review 

of available data regarding virulence of 

FMD–LL3B3D vaccines. Several FMD– 

LL3B3D vaccine viruses have been 

derived in vitro and characterized for 

their virulence in cattle and pigs. The 

cumulative data have shown that these 

FMD–LL3B3D marker viruses are highly 

attenuated in their natural hosts. Safety 

studies involving direct inoculation of 

live FMD–LL3B3D virus in cattle and 

pigs (see table 1) showed a high 

restriction of the novel vaccine virus to 

replicate and resulted in no clinical 

disease or transmission.4

TABLE 1—LIVE INNOCUITY STUDIES USING A VARIETY OF FMDLL3B3D VACCINE STRAINS IN CATTLE AND SWINE 1

Construct Inoculation route Number of 

animals Results 

Cattle: 

FMD–LL3B3D–A24 Cruzeiro ............ Intralingual (7×106) .................................. 2 • No clinical disease. 

FMD–LL3B3D–A24 Cruzeiro ............ Aerosol (1×106 to 3×106) ........................ 3 • No viral shedding. 

FMD–LL3B3D–A24 Cruzeiro ............ Aerosol and Contact/(1×106) ................... 9 • No fever spikes. 

• No contact transmission. 

• Very limited if any immune response. 

Swine: 

FMD–LL3B3D–A24 Cruzeiro ............ Heelbulb and Contact (1×105) ................ 4 • No clinical disease. 

FMD–LL3B3D–Asia1 Shamir ........... Heelbulb and Contact (1×106) ................ 5 • No viral shedding. 

FMD–LL3B3D–A Turkey 06 ............. Heelbulb and Contact (1×106) ................ 5 • No fever spikes. 

FMD–LL3B3D–O1 Campos ............. Heelbulb and Contact (1×106) ................ 4 • No contact transmission. 

FMD–LL3B3D–A Argentina .............. Heelbulb and Contact (2×106) ................ 4 • Very limited if any immune response. 

FMD–LL3B3D–C3 Indaial ................ Heelbulb and Contact (2.8×106) .............. 4 

1 Data prepared by Foreign Animal Disease Research Unit, USDA/ARS, Plum Island Animal Disease Center. 

We are therefore reopening the 

comment period on Docket No. APHIS– 

2020–0054 for an additional 30 days. 

This action will allow interested 

persons to prepare and submit 

comments on the additional information 

we provided. We will also consider all 

comments received between September 

14, 2020, and the date of this notice. 

Authority: 7 U.S.C. 1633, 7701–7772, 

7781–7786, and 8301–8317; 21 U.S.C. 136 

and 136a; 31 U.S.C. 9701; 7 CFR 2.22, 2.80, 

and 371.4. 

Done in Washington, DC, this 25th day of 

November 2020. 

Mark Davidson, 

Acting Administrator, Animal and Plant 

Health Inspection Service. 

[FR Doc. 2020–26560 Filed 12–1–20; 8:45 am] 

BILLING CODE 3410–34–P 

DEPARTMENT OF AGRICULTURE 

Forest Service 

Medicine Bow-Routt National Forests 

and Thunder Basin National 

Grassland; Wyoming; 2020 Thunder 

Basin National Grassland Plan 

Amendment 

AGENCY: Forest Service, USDA. 

ACTION: Notice of Grassland Plan 

amendment approval. 

SUMMARY: Russell M. Bacon, Forest 

Supervisor for the Medicine Bow-Routt 

National Forests and Thunder Basin 

National Grassland, Rocky Mountain 

Region, signed the final Record of 

Decision (ROD) for the 2020 Thunder 

Basin National Grassland Land and 

Resource Management Plan Amendment 

(Grassland Plan amendment). The Final 

ROD documents the rationale for 

approving the Grassland Plan 

amendment and is consistent with the 

Reviewing Officer’s response to 

objections and instructions. 

DATES: The effective date of the 

Grassland Plan amendment is 30 days 

after publication of notice of Grassland 

Plan amendment approval in the 

newspaper of record, the Laramie 

Boomerang. 

ADDRESSES: To view the final ROD, final 

environmental impact statement (FEIS), 

FEIS errata, objection responses, and 

other related documents, visit the 2020 

Thunder Basin National Grassland Plan 

Amendment website at https://

www.fs.usda.gov/project/ 

?project=55479. 

FOR FURTHER INFORMATION CONTACT: 

Monique Nelson, plan amendment team 

leader, by email at monique.nelson@

usda.gov or by telephone at 307–275– 

0956. 

Individuals who use 

telecommunication devices for the deaf 

(TDD) may call the Federal Information 

Relay Service (FIRS) at 1–800–877–8339 

Federal Register / Vol. 85, No. 232 / Wednesday, December 2, 2020 / Notices 77427 

between 8 a.m. and 8 p.m., Eastern 

Time, Monday through Friday. 

SUPPLEMENTARY INFORMATION: The 

Grassland Plan amendment addresses 

management of black-tailed prairie dog 

colonies on National Forest System land 

within the administrative boundary of 

the Thunder Basin National Grassland. 

New and amended plan components 

remove a 56,000-acre ‘‘Black-footed 

Ferret Reintroduction Habitat’’ 

management area and designate a new 

42,000-acre ‘‘Short-Stature Vegetation 

Emphasis’’ management area; set an 

objective of 10,000 acres of prairie dog 

colonies for conservation of wildlife 

habitat; establish prairie dog 

management zones along boundaries 

between National Forest System land 

and private or state properties; allow 

broader application of tools for prairie 

dog colony control; and increase 

emphasis on management of sylvatic 

plague. The Grassland Plan amendment 

was informed by the best available 

scientific information, current laws and 

regulations, and collaborative 

relationships with cooperating agencies 

and stakeholder groups. 

Cooperating Agencies 

U.S. Fish and Wildlife Service, 

Wyoming Field Office; Natural 

Resources Conservation Service, 

Wyoming State Office; Wyoming 

Department of Agriculture; Wyoming 

Game and Fish Department; Wyoming 

State Office of Lands and Investments; 

Wyoming Weed and Pest Council; 

Campbell County, WY; Converse 

County, WY; Crook County, WY; 

Niobrara County, WY; Weston County, 

WY. 

Responsible Official 

Russell M. Bacon, Forest Supervisor, 

Medicine Bow Routt National Forests 

and Thunder Basin National Grassland. 

Christine Dawe, 

Acting Associate Deputy Chief, National 

Forest System. 

[FR Doc. 2020–26563 Filed 12–1–20; 8:45 am] 

BILLING CODE 3411–15–P 

COMMISSION ON CIVIL RIGHTS 

Agenda and Notice of Public Meeting 

of the Delaware Advisory Committee 

AGENCY: Commission on Civil Rights. 

ACTION: Announcement of meetings. 

SUMMARY: Notice is hereby given, 

pursuant to the provisions of the rules 

and regulations of the U.S. Commission 

on Civil Rights (Commission), and the 

Federal Advisory Committee Act 

(FACA), that planning meetings of the 

Delaware Advisory Committee to the 

Commission will convene by conference 

call, on the following Wednesdays at 

1:00 p.m. (ET): November 4 and 

December 2, 2020 and January 6 and 

February 3, 2021. The purpose of the 

meetings is for project planning and 

possible selection of project topic and 

project proposal. 

DATES: Wednesdays at 1:00 p.m. (ET), 

November 4 and December 2, 2020 and 

January 6 and February 3, 2021. 

ADDRESSES: Public Call-In Information: 

Conference call number: 1–800–367– 

2403 and conference call ID: 4195799. 

FOR FURTHER INFORMATION CONTACT: Ivy 

L. Davis, at ero@usccr.gov or by phone 

at 202–376–7533. 

SUPPLEMENTARY INFORMATION: Interested 

members of the public may listen to the 

discussion by calling the following tollfree conference call number: 1–800– 

367–2403 and conference call ID: 

4195799. Please be advised that before 

placing them into the conference calls, 

the conference call operator may ask 

callers to provide their names, their 

organizational affiliations (if any), and 

email addresses (so that callers may be 

notified of future meetings). Callers can 

expect to incur charges for calls they 

initiate over wireless lines, and the 

Commission will not refund any 

incurred charges. Callers will incur no 

charge for calls they initiate over landline connections to the toll-free 

telephone number herein. 

Individuals who are deaf, deafblind 

and hard of hearing may also follow the 

proceedings by first calling the Federal 

Relay Service at 1–800–877–8339 and 

providing the Federal Relay Service 

operator with the conference call-in 

numbers: 1–800–822–2024 and 

conference call ID: 4195799. 

Members of the public are invited to 

make brief statements during the Public 

Comment section of each meeting or to 

submit written comments. The 

comments must be received in the 

regional office approximately 30 days 

after each scheduled meeting via email 

to Ivy Davis at ero@usccr.gov. 

Records and documents discussed 

during the meeting will be available for 

public viewing, as they become 

available, at www.facadatabase.gov. 

Persons interested in the work of this 

advisory committee are advised to go to 

the Commission’s website, 

www.usccr.gov, or to contact the Eastern 

Regional Office at the above email 

address. 

Agenda 

Wednesdays at 1:00 p.m. (ET): Nov. 4 

and Dec. 2, 2020 and Jan. 6 and Feb. 3, 

2021 

I. Welcome and Roll Call 

II. Project Planning 

III. Other Business 

IV. Next Planning Meeting 

V. Public Comments 

VI. Adjourn 

Dated: November 25, 2020. 

David Mussatt, 

Supervisory Chief, Regional Programs Unit. 

[FR Doc. 2020–26553 Filed 12–1–20; 8:45 am] 

BILLING CODE 6335–01–P 

DEPARTMENT OF COMMERCE 

Foreign-Trade Zones Board 

[S–174–2020] 

Approval of Subzone Expansion; 

ASML US, LLC; Wilton, Connecticut 

On October 5, 2020, the Executive 

Secretary of the Foreign-Trade Zones 

(FTZ) Board docketed an application 

submitted by the Bridgeport Port 

Authority, grantee of FTZ 76, requesting 

an expansion of Subzone 76A subject to 

the existing activation limit of FTZ 76, 

on behalf of ASML US, LLC, in Wilton, 

Connecticut. 

The application was processed in 

accordance with the FTZ Act and 

Regulations, including notice in the 

Federal Register inviting public 

comment (85 FR 63505, October 8, 

2020). The FTZ staff examiner reviewed 

the application and determined that it 

meets the criteria for approval. Pursuant 

to the authority delegated to the FTZ 

Board Executive Secretary (15 CFR 

400.36(f)), the application to expand 

Subzone 76A was approved on 

November 25, 2020, subject to the FTZ 

Act and the Board’s regulations, 

including Section 400.13, and further 

subject to FTZ 76’s 476-acre activation 

limit. 

Dated: November 25, 2020. 

Andrew McGilvray, 

Executive Secretary. 

[FR Doc. 2020–26578 Filed 12–1–20; 8:45 am] 

BILLING CODE 3510–DS–P