S-Metolach lor Dietary Expos ur e and Ri sk Assessment 

### DP # 04 25 1 69



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON

, 

### D.C

. 20460



### M EM ORANDUM

D ate : 05/7 / 2015 OFFICE OF CHEMICA L SAFETY AND
POLLUTION PREVENTION



### SU BJE CT: S-meto l ac hlor

- Acute and Chronic Agg r egate Dietar y (Food and Drinkin g Water) Exposure and Risk Assessment for Estab li s hment of To l e rance s fo r New

Uses on Lettuce

, Low Growi n g Berr y Subg r o up l 3-07G, except Cra nb e rr y; Vegetable

, Cucurbit

, Group 9; Su nfl ower subgroup 20 8 ; Vegetable

, Fruiting

, Group 

## 8- l O; except Tabasco Pepper.

.

P C Co d e: I 08800

Deci s ion No.: 488023

P e tition No.: 4E8248

Ri s k Assessme n t T y p e: Dietary

TXR No.: NA

MRID No.: NA



### F rom: Thurston G. Morton

, Chemist

Risk Assessment Br anc h IV / Healt DP Barc o d e: 0425169

Re g i s trati o n No.: I 00-816

· R eg ul atory Ac tion: Section 3 Re gistration

Ca se No.: 000 I

C AS No.: 87392-1 2 -9

40 C F : § 1 80.368

# -~ f ects Di v i sion ( R A B I V/HED ; 7509 P )

T h roug h: Dou g l as D otson, Ph.D.

, Senior Che mi st /).

## ~~ Nancy Dodd

, C hemi st**~ ~**  

### Diet ary Exposure Science Advistfr'y Council (DESAC)

An d

Elissa R eaves PhD

., Branch Chief


## RAB IV / H ED (7509 P )

To: Barbara Madden/Sidney Jackson

, PM # 5

M in o r Use 

### & Emergency R espo n se Branch

Re gist r at ion Division (7505P)

P age I 

### of24

### S- Metolachlor Dietary Exposure and Ri sk Assessment DP # 0425169



### Exec uti ve S umma ry

Acute and chronic aggregate dietary [food and drinking water] exposu r e and risk assessments

we re conducted usin g the Dietar y Exposure Eva luation Model softwa r e with the Food

Co mmodity Intak e Database ( DE EM-FCID) Version 3.16. This softwa r e u ses 2003-2008 food consumption data from th e U.S. Department of Agriculture's (US D A's) Nat i onal Health and

Nut riti on Exam in ation Survey

, What We Eat in America (NHANES / WWETA). The 

### anal yses

were conducted in s upport of a human-health risk assessment 

### for the propo sed Section 

### 3 of S

metolachlor on lettuce

, low grow ing berry s ub group l 3-07G

, except cranberry ; vegeta bl e
,

c ucurbit

, group 

### 9 ; vegetable, fruiting , g roup 

### 8- 1 O; excep t taba sco p eppe r and okra

, and s unflo we r

s ubgroup 

### 208.

T hi s m e morandum was r ev iew e d by two pe e r revi ewe rs of the DESA C per DESA C SOP 20 1 2. 

### l.

/\cute Dietary Exposure R es ult s and C haract e rization

/\.conservative acute di e t a ry exposure analysis wa s performed for the ge n eral U.S. population



### a

nd va ri ous popula tion subgroups. Tolerance-leve l residues and 

### I 00 pe rc ent crop treated

ass umption s we r e u se d. DEEM default proc ess in g factors wer e u se d to modi fy th e tolerance

values. Th e acute a nal ys i s inc o rp o rat e d the l in 

### 10 year peak groun dw a ter es timat e from

app li cat i on of S-metolachlor on cotton. Thi s assessment concludes th a t

, for a ll supported

co mm od iti es
, the acu te dietary exposu r e estimates are below H E D 's l eve l of concern. Th e 

### 95 111



### percentile ac ute di e ta ry expos ur e estimates fo r th e ge n era l U.S. population and th e high est

expose d population s ub g r o up , a ll infant s < I 

### year o ld

, are 2 .1 

### % and 6. 1 

### %, r es pectiv e ly

, of th e

ac ut e populat i on adjusted dose 

### (a. PAD ).

Chro ni c Di etary Exposure Re su lt s and Characte ri zat ion



### A conservative chronic dietary exposure analysis was performed for the general 

### U.S. population

a nd various popul a tion s ubgroups. Tolerance-level residues and 100 pe rc ent crop treat ed

ass u mpt ion s we r e used. 

### DEEM default pr ocess in g factors were u se d to modif y the tolerance

values. Th e c hr o ni c anal ys i s in co rporated the 

### I 0 yea r average s urface drinking water estimate

from app lic a tion of S

- m e tolachlor to l e ttuc e. The c hroni c dietar y e xp os ure est imat e for t h e

ge n e r a l U

. S. population a nd th e high est exposed population subgrou p
, c hildr e n 1- 2 

### ye ar s old

, i s

6 .8 % a nd 3.1 % of the chronic p o pulation adjusted dose (c PAD)

, resp ec tively.



### l. 

### Introduction

Dietar y ri sk assess ment incorporates both ex po s ur e and t ox icit y of a give n p es ticid e. F o r acute

and c hroni c assess m e nt s
, the risk is exp re ssed as a percentage of a m axi mum acceptable dose
( i .e., the do se that I 

### l ED h as concluded will res ult in no unreas o nabl e adverse health effec t s)

. T hi s dose i s r eferred to as the population-adjusted dose 

### ( PAD )

. Th e P A D i s e qui va l e nt t o the

P age 

### 2of24S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 3 of 24 point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety

factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2 000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

1999).

The most recent dietary risk assessment for S

- metolachlor was conducted by R. Duncan ( D 3 96451, 1/3/12 ) for the Section 3 use on cilantro and garden beet leaves

.

II. Residue Information

Metolachlor (PC Code 108801) is a racemic herbicide that consists of 50% each of the R

enantiomer and the S

- enantiomer. S

- metolachlor products are an isomer enriched formula comprised of 88% S

- isomer and 12% R

- isomer. The residues of concern for S

- metolachlor are the same as those for metolachlor (D226780, L. Kutney, 11/12/96). The Metabolism Assessment Review Committee (MARC , 8/14/001 ) determined that the residues of concern for plant and

livestock commodities are metolachlor and its metabolites, determined as the derivatives 2

- [(2

- ethyl

- 6

- methylphenyl)amino]

- 1

- propanol ( CGA

- 37913) and 4

- (2

- ethyl

- 6

- methylphenyl)

- 2

- hydroxy

- 5

- methyl

- 3

- morpholinone ( CGA

- 49751). Metabolites of metolachlor are assumed t o be toxicologically equivalent to parent metolachlor. Permanent tolerances are established in 40 CFR § 180.368(a)(2) for S

- metolachlor , including its metabolites and degra dates in/on a variety of crop commodities, at levels ranging from 0.02 in/on meat a nd dairy products to 20 ppm in/on peanut hay. Compliance with the tolerance levels is to be determined by measuring S

metolachlor, its R

- enantiomer, and the two metabolites CGA

- 37913 and CGA

- 49751. In cases where separate tolerance listings occur for both metolachlor and S

- metolachlor on the same commodity, the higher value of the two is used in the analyses. Residues used in the acute and chronic dietary analyses are provided in Tables 1 , 2, 3 and 4.

The recommend ed tolerances for the proposed commodit ies are as follows: 1.5 ppm on lettuce, 0.50 ppm on vegetable, cucurbit group 9, 0.10 ppm on vegetable, fruiting group 8

- 10, except tabasco pepper and okra, 0.40 ppm on low growing berry subgroup 13

- 07G except cranberry, and 0.50 ppm on sunflower subgroup 20B (S. Hummel, D420046, 10/27/14)

.S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 4 of 24 Table 1. Metolachlor Tolerances Commodity Tolerance (ppm) Cattle, fat; Cattle, meat 0.02 Cattle, kidney 0.2 0
Cattle, liver 0.05 Cattle, meat byproducts, except kidney and liver 0.04 Corn, field, grain 0.1 0 Corn, pop, grain 0.10 Corn, sweet, kernel plus cob with husks removed 0.1 0
Cotton, undelinted seed 0.1 0

Dillweed 0.5 0 Egg 0.02
Goat, fat; Goat, meat 0.02 Goat, kidney 0.2 0
Goat, liver 0.05 Goat, meat byproducts, except kidney and liver 0.04
Horse, fat; Horse, meat 0.02 Horse, kidney 0.2 0
Horse, liver 0.05 Horse, meat byproducts, except kidney and liver 0.04

Milk 0.02 Nut, tree, group 14 0.1 0

Okra 0.5 0

Peanut 0.2 0 Pepper, nonbell (Sec 18) 0.50

Potato 0.2 0 Poultry, fat; Poultry, meat 0.02 Poultry, meat byproducts 0.05 Sheep, fat; Sheep, meat 0.02 Sheep, kidney 0.2 0 Sheep, liver 0.05 Sheep, meat byproducts, except kidney and liver 0.04 Sorghum, grain, grain 0.3 0 Soybean, seed (superseded by legume tolerance of 0.3 ppm) 0.2 0

Tomato 0.1 0 Vegetable, legume, group 6 0.3 0

Table 2. S

- metolachlor Tolerances Commodity Tolerance (ppm) Asparagus 0.1 0
Beet, garden

, leaves 1.8 Beet, sugar, molasses 2 .0 Beet, sugar, roots 0.5 0 Beet, sugar, tops 15 Brassica, head and stem, subgroup 5A 0.6 0
Brassica, leafy greens , subgroup 5 B 1.8 Bushberry subgroup 13

- 07B 0.15 Caneberry, s ubgroup 13

- 07A 0.1 0 Low grow berry subgroup 13

- 07G (except cranberry) 0.40S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 5 of 24 Table 2. S

- metolachlor Tolerances Commodity Tolerance (ppm)

Carrot , roots 0.40
Cattle, fat; Cattle, meat 0.02 Cattle, kidney 0.2 0
Cattle, liver 0.05 Cattle, meat byproducts, except kidney and liver 0.04
Cilantro, leaves 8.0
Coriander, seed 0.13 Corn, field, grain 0.1 0 Corn, pop, grain 0.1 0 Corn, sweet, kernel plus cob with husks removed 0.1 0
Cotton, undelinted seed 0.1 0 Egg 0.02
Goat, fat; Goat, meat 0.02 Goat, kidney 0.2 0
Goat, liver 0.05 Goat, meat byproducts, except kidney and liver 0.04
Horse, fat; Horse, meat 0.02 Horse, kidney 0.2 0
Horse, liver 0.05 Horse, meat byproducts, except kidney and liver 0.04 Leaf petioles, subgroup 4B 0.1 0

Milk 0.02

Okra 0. 50
Onion, b ulb, s ubgroup 3

- 07A 0.1 0
Onion, g reen, s ubgroup 3

- 07B 2 .0

Peanut 0.2 0 Pepper, tabasco (regional registration) 0.50 Poultry, fat; Poultry, meat 0.02 Poultry, meat byproducts 0.05
Safflower, seed 0.1 0
Sesame, seed 0.13 Sheep, fat; Sheep, meat 0.02 Sheep, kidney 0.2 0 Sheep, liver 0.05 Sheep, meat byproducts, except kidney and liver 0.04 Sorghum, grain, grain 0.3 0 Soybean, seed (superseded by legume tolerance of 0.3 ppm) 0.2 0 Spinach 0.5 0
Sunflower, seed 0.5 0 Tomato, paste 0.3 0 Vegetable, fruiting, group 8, except tabasco pepper 0.1 0 Vegetable, legume, group 6 0.3 0 Vegetable, root, except sugar beet, subgroup 1B except carrot 0.3 0 Vegetable, tuberous and corm, subgroup 1C 0.2 0S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 6 of 24 Table 3. Metolachlor Inadvertent Tolerances

Commodities Tolerance (ppm) Barley, grain 0.10 Buckwheat, grain 0.10 Millet, grain 0.10 Oat, grain 0.10 Rice, grain 0.10 Rye, grain 0.10 Wheat, grain 0.10

Table 4. S

- metolachlor Inadvertent Tolerances Commodity Tolerance (ppm) Barley, grain 0.10 Buckwheat, grain 0.10 Millet, grain 0.10 Oat, grain 0.10 Rice, grain 0.10 Rye, grain 0.10 Wheat, grain 0.10



### Residues in Fish : In 2008, 2009, and 2010 the USDA Pesticide Data Program (PDP) analyzed catfish samples for metolachlor. There was only 1 detected residue of metolachlor.

I I I. Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop treated (CT).

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: “ Tier II Drinking Water Asses sment for the P roposed S

- Metolachlor Use on Lettuce (Head and Leaf),

Low

- Growing Berry Subgroup 13

- 07G (excluding Cranberry), Cucurbit Vegetable Group 9, Sunflower Subgroup 20B and Fruiting Vegetable Group 8

- 10. ” ( D 420047

, C. Koper

, 12/16/14 ) and incorporated directly into this dietary assessment. Water residues were incorporated in the

DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all

sources.”

Following the recent recommendation of the Residues of Concern Knowledgebase

Subc ommittee (D424250), parent metolachlor, CGA

- 51202 (metolachlor

- OA), CGA

- 40172, and

CGA

- 50720 will be assessed together in the drinking water assessment using a total toxic residues (TTR; USEPA 2009a) approach where half

- lives were recalculated (PestDF; USE PA, 2009b) to collectively account for the parent and the combined residues of concern. These values will be utilized in surface and ground water modeling to generate aquatic exposure

estimates.S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 7 of 24 Recommended EDWCs of S

- metolachlor in surface water and grou nd water are reported in

Table 5. The EDWC used in the acute assessment is 1.060 ppm. The EDWC used in the chronic assessment is 0.0437 ppm.

The acute EDWC is a ground water value generated using the Pesticide Root Zone Model

– Ground Water (PRZM

- GW) based on a 30 year simulation of 2 foliar applications of 2.0 lbs

a.i./A for a maximum annual rate of 4.0 lbs a.i/A for corn/cotton.

The chronic EDWC is a surface water value generated using the Surface Water Concentration

Calculator ( SWCC ) model using a e rial application with a percent crop treated (P CA ) factor of

0.91 , based on the c urrent proposed use on lettuce (2 apps x 0.95 lbs a.i./A x 2 seasons).

Table 5

. Recommended EDWCs for S

- Metolachlor Use on Various Crops

Drinking Water

Source Crop Scenario 1

- in

- 10 year

acute
( 

### μg/L ) 1

- in

- 10 year

chronic
( 

### μg/L ) 30

- year average

cancer chronic
( 

### μg/L )

Surface Water MS Corn 1 (aerial) 

### 371

-- --

CA Lettuce 2 (aerial)



### -- 43.70 * 21.80

Ground Water NC Cotton 3 (aerial) 

### 1060 * NA

--

WI Corn 3 (aerial)



### -- NA 978

1 EDWC calculated from the maximum rate (2 apps x 2.0 lbs a.i./A) registered on corn and cotton generated using

SWCC model (aerial application; TTR approach) with a PCA factor of 0.91.

2 Current proposed use on lettuce (2 apps x 0.95 lbs a.i./A x 2 seasons).

3 Highest EDWCs generated using PRZM

- GW model based on a 30 year simulation of 2 foliar applications of 2.0 lbs a.i./A for a maximum annual rate of 4.0 lbs a.i/A for corn/cotton (Metolachlor RED; D185152, 172022 )

.
* Bolded concentrations w ere used in the acute and chronic dietary exposure analyses.



### V. DEEM

- FCID Program and Consumption Information

S

- metolachlor acute and chronic dietary exposure assessments were conducted using the DEEM

FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g.

, apples , peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the ent ire U.S. population and within population subgroups . However , for acute
exposure assessment

, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following populatio n subgroups: the general U.S. population, all infants (<1 year old), childrenS

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 8 of 24 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue lev el in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent

of the cPAD. Th is procedure is performed for each population subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a re sidue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of e xposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In acco rdance with HED policy, per capita exposure and risk are reported for a nalyses performed at all levels of refinement . However, for

deterministic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

VI. Toxicological Information

HED evaluated the toxicology database for S

- metolachlor and selected the following doses and endpoints for acute and chronic dietary and drinking water risk assessments.S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 9 of 24 Table 6. Summary of Toxicological Endpoints for S

- metolachlor for Use in Dietary Human Health Risk

Assessments

Exposure
Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD,

LOC for Risk

Assessment Study and Toxicological Effects

Acute Dietary (general population) NOAEL =

300 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Acute RfD =

3.0 mg/kg/day

aPAD = 3.0 mg/kg/day Developmental Toxicity Study

- Rat

LOAEL = 1000 mg/kg/day based on increased incidence of death, clinical signs (clonic and/or tonic convulsions, excessive salivation, urine

- stained abdominal fur and/or excessive lacrimation) and decreased body weight gain.

Chronic Dietary (all populations) NOAEL =

9.7 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Chronic RfD =

0.097 mg/kg/day

cPAD = 0.097mg/kg/day Chronic Toxicity

- Dog;

LOAEL = 33 mg/kg/day based decreased body weight gain in females

Cancer (all routes) Metolachlor has been classified as a Group C carcinogen with risk quantitated using a non

- linear

(Margin of Exposure) approach.
Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to m ark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.

NOAEL = no observed adverse effect level.

LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolati on from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic).

RfD = reference dose.



### V II. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The r esults reported in Table 7 below are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years old.S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169



### Page 10 of 24 Table 7 Summary of Dietary Food and Drinking Wate r Exposure and Risk for

S

- metolachlor and Metolachlor

.

Population Subgroup Acute Dietary ( 95th Percentile) Chronic Dietary

Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD*

General U.S. Population 0.0613 69 2.1 0.0030 08 3 .1

All Infants (<1 year old) 0.184 165 6.1 0.0056 52 5.8

Children 1

- 2 years old 0.096 061 3.2 0.006 557 6. 8

Children 3

- 5 years old 0.07 7899 2.6 0.005 513 5. 7

Children 6

- 12 years old 0.059 378 2.0 0.003 690 3. 8

Youth 13

- 19 years old 0.0 49953 1.7 0.0024 07 2.5

Adults 20

- 49 years old 0.0 59238 2.0 0.002 687 2.8

Adults 50

- 99 years old 0.0535 03 1.8 0.00 26 44 2. 7

Females 13

- 49 years old 0.0599 90 2.0 0.00 2 687 2.8
*The subpopulation (s) with the highest risk estimates are bolded

.



### VIII. Characterization of Inputs/Outputs

The acute and chronic analyses assumed tolerance

- level residues, 100% CT, and DEEM default processing factors. Therefore, these analyses are considered conservative. While they could be significantly refined, further r efinement is not warranted as estimated risks are not of concern.

IX. Conclusions

Based on analyses of estimated dietary risks for the general U.S. population and various population subgroups, the acute and chronic dietary exposure estimates for S

- m etolachlor are significantly below HED’s level of concern for all supported commodities . The 95th percentile acute dietary exposure estimate for the highest exposed population subgroup, all infants < 1 year

old is 6.1 % of the aPAD. The chronic dietary ex posure estimate for the highest exposed population subgroup, children 1

- 2 year s old is 6. 8 % of the cPAD.

X. List of Attachments

1. Acute DEEM

- FCID Residue Input File.

2. Results of Acute DEEM

- FCID Dietary Exposure Analysis.

3. Chronic DEEM

- FCID Residue Input File.

4. Results of Chronic DEEM

- FCID Dietary Exposure Analysis.S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 11 of 24 

### Attachment 1 Acute DEEM

- FCID Residue Input File

Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 108800 s

- Metolachlor \ 108800 Acut e Food plus Water.r08

Chemical: s

- Metolachlor and Metolachlor RfD(Chronic): .097 mg/kg bw/day NOEL(Chronic): 9.7 mg/kg bw/day RfD(Acute): 3 mg/kg bw/day NOEL(Acute): 300 mg/kg bw/day
Date created/last modified: 01

- 22

- 2015/09:35:41 Program ver. 3.1 6, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.300000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 0.300000 1.000 1.000

0101052000 1A Be et, sugar 0.500000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.500000 1.000 1.000 0101053000 1A Beet, sugar, molasses 2.000000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- babyf ood 2.000000 1.000 1.000

0101067000 1AB Burdock 0.300000 1.000 1.000

0101078000 1AB Carrot 0.400000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.400000 1.000 1.000 0101079000 1AB Carrot, juice 0.400000 1.000 1.000

0101084000 1AB Celeriac 0.300000 1.000 1.000 0101100000 1AB Chicory, roots 0.300000 1.000 1.000

0101168000 1AB Ginseng, dried 0.300000 1.000 1.000

0101190000 1AB Horseradish 0.300000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.300000 1.000 1.000 0101251000 1AB Parsnip 0.300000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.300000 1.000 1.000 0101314000 1AB Radish, roots 0.300000 1.000 1.000
0101316000 1AB Radish, Oriental, roots 0.300000 1.00 0 1.000 0101327000 1AB Rutabaga 0.300000 1.000 1.000 0101331000 1AB Salsify, roots 0.300000 1.000 1.000 0101388000 1AB Turnip, roots 0.300000 1.000 1.000
0103015000 1CD Arrowroot, flour 0.200000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.200000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.200000 1.000 1.000

0103082000 1CD Cassava 0.200000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.200000 1.000 1.000 0103139000 1CD Dasheen, corm 0.200000 1.000 1.000 0103166000 1CD Ginger 0.200000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.200000 1.000 1.000 0103167000 1CD Ginger, dried 0.200000 1.000 1.000 0103296000 1C Potato, chips 0.200000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.200000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.200000 6.500 1.000
0103298000 1C Potato, flour 0.200000 6.500 1.000 0103298001 1C Potato, flour

- babyfood 0.200000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.200000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.200000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.200000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.200000 1.000 1.000 0103366000 1CD Sweet potato 0.200000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.200000 1.000 1.00 0 0103371000 1CD Tanier, corm 0.200000 1.000 1.000

0103387000 1CD Turmeric 0.200000 1.000 1.000
0103406000 1CD Yam, true 0.200000 1.000 1.000

0103407000 1CD Yam bean 0.200000 1.000 1.000 0200051000 2 Beet, garden, tops 1.800000 1.000 1.000 0301165000 3A Garlic, bulb 0.100000 1.000 1.000 0301165001 3A Garlic, b ulb

- babyfood 0.100000 1.000 1.000 0301237000 3A Onion, bulb 0.100000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0.100000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 0.100000 9.000 1.000
0301338000 3A Shallot, bulb 0.100000 1.000 1.000 0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000

0302198000 3B Leek 2.000000 1.000 1.000 0302239000 3B Onion, green 2.000000 1.000 1.000
0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 12 of 24 0401204000 4A Lettuce , head 1.500000 1.000 1.000
0401205000 4A Lettuce, leaf 1.500000 1.000 1.000 0401355000 4A Spinach 0.500000 1.000 1.000 0401355001 4A Spinach

- babyfood 0.500000 1.000 1.000

0402076000 4B Cardoon 0.100000 1.000 1.000 0402085000 4B Celery 0.100000 1.000 1.000 0402085001 4B Celery

- babyfood 0.100000 1.000 1.00 0 0402086000 4B Celery, juice 0.100000 1.000 1.000

0402087000 4B Celtuce 0.100000 1.000 1.000
0402152000 4B Fennel, Florence 0.100000 1.000 1.000

0402322000 4B Rhubarb 0.100000 1.000 1.000

0402367000 4B Swiss chard 0.100000 1.000 1.000

0501061000 5A Broccoli 0.600000 1.000 1.000

0501061001 5A Broccoli

- babyfood 0.600000 1.000 1.000 0501062000 5A Broccoli, Chinese 0.600000 1.000 1.000 0501064000 5A Brussels sprouts 0.600000 1.000 1.000 0501069000 5A Cabbage 0.600000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.600000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 0.600000 1.000 1.000

0501083000 5A Cauliflower 0.600000 1.000 1.000

0501196000 5A Kohlrabi 0.600000 1.000 1.000

0502063000 5B Broccoli raab 1.800000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 1.800000 1.000 1.000

0502117000 5B Collard s 1.800000 1.000 1.000

0502194000 5B Kale 1.800000 1.000 1.000 0502229000 5B Mustard greens 1.800000 1.000 1.000 0502318000 5B Rape greens 1.800000 1.000 1.000 0502389000 5B Turnip, greens 1.800000 1.000 1.000 0600347000 6 Soybean, seed 0.300000 1.000 1.000 0600349000 6 Soybean, soy milk 0.300000 1.000 1.00 0 0600349001 6 Soybean, soy milk

- babyfood or in 0.300000 1.000 1.000 0600350000 6 Soybean, oil 0.300000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.300000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.300000 1.000 1.000 0601043001 6A Bean, snap, succulent

- babyfood 0.300000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 0.300000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.300000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.300000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.300000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.300000 1.000 1.000
0602255000 6B Pea, succulent 0.300000 1.000 1.000 0602255001 6B Pea, succulent

- babyfood 0.300000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 0.300000 1.000 1.000
0603030000 6C Bean, black, seed 0.300000 1.000 1.000
0603032000 6C Bean, broad, seed 0.300000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.300000 1.000 1.000
0603035000 6C Bean, great northern, seed 0.300000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.300000 1.000 1.000
0603038000 6C Bean, lima, seed 0.300000 1.000 1.000 0603039000 6C Bean, mung, seed 0.300000 1.000 1.000 0603040000 6C Bean, navy, seed 0.300000 1.000 1.000 0603041000 6C Bean, pink, seed 0.300000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.300000 1.000 1.00 0 0603098000 6C Chickpea, seed 0.300000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.300000 1.000 1.000 0603099000 6C Chickpea, flour 0.300000 1.000 1.000
0603182000 6C Guar, seed 0.300000 1.000 1.000
0603182001 6C Guar, seed

- babyfood 0.300000 1.000 1.000 0603203000 6C Lentil, seed 0.300000 1.000 1.000 0603256000 6C Pea, dry 0.300000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.300000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.300000 1.000 1.000 0603348000 6C Soybean, flour 0.300000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.300000 1.000 1.000

0801374000 8A Tomatillo 0.100000 1.000 1.000

0801375000 8A Tomato 0.100000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.100000 1.000 1.000 0801376000 8A Tomato, paste 0.300000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.300000 1.000 1.000
0801377000 8A Tomato, puree 0.100000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.100000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 13 of 24 0801378000 8A Tomato, dried 0.100000 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 0.100000 14.300 1.000 0801379000 8A Tomato, juice 0.100000 1.500 1.000
0801380000 8A Tomato, Tree 0.100000 1.000 1.000 0802148000 8BC Eggplant 0.100000 1.000 1.00 0

0802234000 8BC Okra 0.500000 1.000 1.000 0802270000 8B Pepper, bell 0.100000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 0.100000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.100000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.500000 1.000 1.000 0802272001 8BC Pepper, n onbell

- babyfood 0.500000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.500000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000

0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000 1301055000 13A Blackberry 0.100000 1.000 1.00 0 1301056000 13A Blackberry, juice 0.100000 1.000 1.000 1301056001 13A Blackberry, juice

- babyfood 0.100000 1.000 1.000 1301058000 13A Boysenberry 0.100000 1.000 1.000 1301208000 13A Loganberry 0.100000 1.000 1.000 1301320000 13A Raspberry 0.100000 1.000 1.000 1301320001 13A Raspberry

- babyfood 0.100000 1.000 1.000 1301321000 13A Raspberry , juice 0.100000 1.000 1.000 1301321001 13A Raspberry, juice

- babyfood 0.100000 1.000 1.000 1302057000 13B Blueberry 0.400000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.400000 1.000 1.000

1302136000 13B Currant 0.150000 1.000 1.000 1302137000 13B Currant, dried 0.150000 1.000 1.000 1302149000 13B Elderberry 0.150000 1.000 1.000 1302174000 13B Gooseberry 0.150000 1.000 1.000 1302191000 13B Huckleberry 0.150000 1.000 1.000 1307359000 13G Strawberry 0.400000 1.000 1.000

1307359001 13G Strawbe rry

- babyfood 0.400000 1.000 1.000 1307360000 13G Strawberry, juice 0.400000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 0.400000 1.000 1.000

1400003000 14 Almond 0.100000 1.000 1.000

1400003001 14 Almond

- babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000 1400004001 14 Almond, oil

- babyfood 0.100000 1.000 1.00 0

1400059000 14 Brazil nut 0.100000 1.000 1.000

1400068000 14 Butternut 0.100000 1.000 1.000

1400081000 14 Cashew 0.100000 1.000 1.000

1400092000 14 Chestnut 0.100000 1.000 1.000

1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 1400185000 14 Hickory n ut 0.100000 1.000 1.000

1400213000 14 Macadamia nut 0.100000 1.000 1.000

1400269000 14 Pecan 0.100000 1.000 1.000

1400278000 14 Pine nut 0.100000 1.000 1.000

1400282000 14 Pistachio 0.100000 1.000 1.000

1400391000 14 Walnut 0.100000 1.000 1.000 1500025000 15 Barley, pearled barley 0.100000 1.000 1.000 1500025001 15 Barley, pearled barley

- babyfood 0.100000 1.000 1.000 1500026000 15 Barley, flour 0.100000 1.000 1.000 1500026001 15 Barley, flour

- babyfood 0.100000 1.000 1.000 1500027000 15 Barley, bran 0.100000 1.000 1.000

1500065000 15 Buckwheat 0.100000 1.000 1.000
1500066000 15 Buckwheat, flour 0.100000 1.000 1.000 1500120000 15 Corn, field, flour 0.100000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 14 of 24 1500120001 15 Corn, field, flour

- babyfood 0.100000 1.000 1.000
1500121000 15 Corn, field, meal 0.100000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.100000 1.000 1.00 0 1500122000 15 Corn, field, bran 0.100000 1.000 1.000 1500123000 15 Corn, field, starch 0.100000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.000 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.100000 1.000 1.000 1500125000 15 Corn, field, oil 0.100000 1.000 1.000
1500125001 15 Corn, fie ld, oil

- babyfood 0.100000 1.000 1.000 1500126000 15 Corn, pop 0.100000 1.000 1.000
1500127000 15 Corn, sweet 0.100000 1.000 1.000 1500127001 15 Corn, sweet

- babyfood 0.100000 1.000 1.000 1500226000 15 Millet, grain 0.100000 1.000 1.000
1500231000 15 Oat, bran 0.100000 1.000 1.000
1500232000 15 Oat, flour 0.100000 1.000 1.000 1500232001 15 Oat, flour

- babyfood 0.100000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.100000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.100000 1.000 1.000 1500323000 15 Rice, w hite 0.100000 1.000 1.000 1500323001 15 Rice, white

- babyfood 0.100000 1.000 1.000 1500324000 15 Rice, brown 0.100000 1.000 1.000 1500324001 15 Rice, brown

- babyfood 0.100000 1.000 1.000 1500325000 15 Rice, flour 0.100000 1.000 1.000
1500325001 15 Rice, flour

- babyfood 0.100000 1.000 1.000 1500326000 15 Rice, bran 0.100000 1.000 1.00 0 1500326001 15 Rice, bran

- babyfood 0.100000 1.000 1.000 1500328000 15 Rye, grain 0.100000 1.000 1.000 1500329000 15 Rye, flour 0.100000 1.000 1.000 1500344000 15 Sorghum, grain 0.300000 1.000 1.000 1500345000 15 Sorghum, syrup 0.300000 1.000 1.000 1500381000 15 Triticale, flour 0.100000 1.000 1.000

1500381001 15 Triticale , flour

- babyfood 0.100000 1.000 1.000 1500401000 15 Wheat, grain 0.100000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.100000 1.000 1.000 1500402000 15 Wheat, flour 0.100000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.100000 1.000 1.000 1500403000 15 Wheat, germ 0.100000 1.000 1.000
1500404000 15 Wheat, bran 0.100000 1.000 1.000

1500405000 15 Wild rice 0.100000 1.000 1.000
1901118000 19A Cilantro, leaves 8.000000 1.000 1.000 1901118001 19A Cilantro, leaves

- babyfood 8.000000 1.000 1.000

1901144000 19A Dillwee d 0.500000 1.000 1.000 1902119000 19B Coriander, seed 0.130000 1.000 1.000
1902119001 19B Coriander, seed

- babyfood 0.130000 1.000 1.000 2001336000 20A Sesame, seed 0.130000 1.000 1.000
2001336001 20A Sesame, seed

- babyfood 0.130000 1.000 1.000 2001337000 20A Sesame, oil 0.130000 1.000 1.000
2001337001 20A Sesame, oil

- babyfood 0.130000 1.000 1.00 0 2002330000 20B Safflower, oil 0.500000 1.000 1.000 2002330001 20B Safflower, oil

- babyfood 0.500000 1.000 1.000
2002364000 20B Sunflower, seed 0.500000 1.000 1.000 2002365000 20B Sunflower, oil 0.500000 1.000 1.000
2002365001 20B Sunflower, oil

- babyfood 0.500000 1.000 1.000 2003128000 20C Cottonseed, oil 0.100000 1.000 1.000

2003128001 20C Cottonsee d, oil

- babyfood 0.100000 1.000 1.000 3100044000 31 Beef, meat 0.020000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.020000 1.000 1.000 3100045000 31 Beef, meat, dried 0.020000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.040000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.040000 1.000 1.000
3100047000 31 Beef, fat 0.020000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 0.050000 1.000 1.000
3100049001 31 Beef, l iver

- babyfood 0.050000 1.000 1.000 3200169000 32 Goat, meat 0.020000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.040000 1.000 1.000 3200171000 32 Goat, fat 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 0.050000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 15 of 24 3300189000 33 Horse, meat 0.020000 1.000 1.00 0 3500339000 35 Sheep, meat 0.020000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.020000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.040000 1.000 1.000 3500341000 35 Sheep, fat 0.020000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, li ver 0.050000 1.000 1.000 3600222000 36 Milk, fat 0.020000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.020000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.020000 1.000 1.000
3600224000 36 Milk, water 0.020000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.020000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.020000 1.000 1.000
3800221000 38 Meat, game 0.020000 1.000 1.000 3900312000 39 Rabbit, meat 0.020000 1.000 1.000

4000093000 40 Chicken , meat 0.020000 1.000 1.000 4000093001 40 Chicken, meat

- babyfood 0.020000 1.000 1.000 4000094000 40 Chicken, liver 0.050000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.050000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.050000 1.000 1.000 4000096000 40 Chicken, fat 0.020000 1.000 1.000
4000096001 40 Chicken, fat

- babyfood 0.020000 1.000 1.00 0 4000097000 40 Chicken, skin 0.050000 1.000 1.000 4000097001 40 Chicken, skin

- babyfood 0.050000 1.000 1.000 5000382000 50 Turkey, meat 0.020000 1.000 1.000

5000382001 50 Turkey, meat

- babyfood 0.020000 1.000 1.000 5000383000 50 Turkey, liver 0.050000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.050000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.050000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.050000 1.000 1.000 5000385000 50 Turkey, fat 0.020000 1.000 1.000 5000385001 50 Turkey, fat

- babyfood 0.020000 1.00 0 1.000 5000386000 50 Turkey, skin 0.050000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.050000 1.000 1.000 6000301000 60 Poultry, other, meat 0.020000 1.000 1.000

6000302000 60 Poultry, other, liver 0.050000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.050000 1.000 1.000 6000304000 60 Poultry, other, fat 0.020000 1.000 1.000 6000305000 60 Poultry, other, skin 0.050000 1.000 1.000 7000145000 70 Egg, whole 0.020000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.020000 1.000 1.000 7000146000 70 Egg, white 0.020000 1. 000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.020000 1.000 1.000 7000147000 70 Egg, yolk 0.020000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 1.060000 1.000 1.000
8602000000 86B Water, indirect, all sources 1.060000 1.000 1.000 9500019000 O Asparagus 0.100000 1.000 1.000

9500263000 O Peanut 0.200000 1.000 1.000
9500264000 O Peanut, butter 0.200000 1.890 1.000 9500265000 O Peanut, oil 0.200000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 16 of 24 

### Attachment 2. Results of Acute DEEM

- FCID Dietary Exposure Analysis

Food and Water

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for S

- METOLACHLOR AND METOLACHLOR

NHANES 2 003

- 2008 2

- Day Residue file: 108800 Acute Food plus Water.r08 Adjustment factor #2 NOT used. Analysis Date: 01

- 22

- 2015/10:57:18 Residue file dated: 01

- 22

- 2015/10:45:01 NOEL (Acute) = 300.000000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.061369 2.05 4888 0.098883 3.30 3033 0.184088 6.14 1629

All Infants:

0.184165 6.14 1628 0.247593 8.25 1211 0.362877 12.10 826

Children 1

- 2:

0.096061 3.20 3123 0.141084 4.70 2126 0.333970 11.13 898

Children 3

- 5:

0.077899 2.60 3851 0.116785 3.89 2568 0.184547 6.15 1625

Children 6

- 12:

0.059378 1.98 5052 0.092547 3.08 3241 0.142872 4.76 2099

Youth 13

- 19:

0.049953 1.67 6005 0.081490 2.72 3681 0.121875 4.06 2461

Adults 20

- 49:

0.059238 1.97 5064 0.087047 2.90 3446 0.124221 4.14 2415

Adults 50

- 99:

0.053503 1.78 5607 0.079765 2.66 3761 0.122829 4.09 2442

Female 13

- 49:

0.059990 2.00 5000 0.087956 2. 93 3410 0.121039 4.03 2478



### Food Only

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for S

- METOLACHLOR AND METOLACHLOR

NHANES 2003

- 2008 2

- Day Residue file: 108800 Acute Food Only.r08 Adjustment factor #2 NOT used. Analysis Date: 01

- 22

- 2015/10:48:53 Residue file dated: 01

- 22

- 2015/10:44:36
NOEL (Acute) = 30 0.000000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 9 9.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.005486 0.18 54682 0.009348 0.31 32093 0.017389 0.58 17252

All Infants:

0.009009 0.30 33299 0.015185 0.51 19756 0.019855 0.66 15109

Children 1

- 2:

0.012003 0.40 24993 0.021911 0.73 13691 0.030840 1.03 9727

Children 3

- 5:

0.009890 0.33 30332 0.016190 0.54 18529 0.030185 1.01 9938

Children 6

- 12:

0.006844 0.23 43835 0.011201 0.37 26783 0.015203 0.51 19733

Youth 13

- 19:

0.004198 0.14 71468 0.007086 0.24 42339 0.014079 0.47 21308S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 17 of 24 Adults 20

- 49:

0.004442 0.15 67539 0.007335 0.24 40901 0.011159 0.37 26884

Adults 50

- 99:

0.004242 0.14 70726 0.006972 0.23 43031 0.010961 0.37 27370

Female 13

- 49:

0.004587 0.1 5 65397 0.007656 0.26 39185 0.012159 0.41 24673S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 18 of 24 

### Attachment 3. Chronic DEEM

- FCID Residue Input File

Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 108800 s

- Metolachlor \ 108800 Chronic Food plus Water.r08

Chemical: s

- Metolachlor and Metolachlor RfD(Chronic): .097 mg/kg bw/day NOEL(Chronic): 9.7 mg/kg bw/day RfD(Acute): 3 mg/kg bw/day NOEL(Acute): 300 mg/kg bw/day
Date created/last modified: 01

- 22

- 2015/09:36:41 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.300000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 0.300000 1.000 1.000

0101052000 1A B eet, sugar 0.500000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.500000 1.000 1.000 0101053000 1A Beet, sugar, molasses 2.000000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- baby food 2.000000 1.000 1.000

0101067000 1AB Burdock 0.300000 1.000 1.000

0101078000 1AB Carrot 0.400000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.400000 1.000 1.000 0101079000 1AB Carrot, juice 0.400000 1.000 1.000

0101084000 1AB Celeriac 0.300000 1.000 1.000 0101100000 1AB Chicory, roots 0.300000 1.000 1.000

0101168000 1AB Ginseng, dried 0.300000 1.000 1.000

0101190000 1AB Horseradish 0.300000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.300000 1.000 1.000 0101251000 1AB Parsnip 0.300000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.300000 1.000 1.000 0101314000 1AB Radish, roots 0.300000 1.000 1.000
0101316000 1AB Radish, Oriental, roots 0.300000 1.000 1.000 0101327000 1AB Rutabaga 0.300000 1.000 1.000 0101331000 1AB Salsify, roots 0.300000 1.000 1.000 0101388000 1AB Turnip, r oots 0.300000 1.000 1.000
0103015000 1CD Arrowroot, flour 0.200000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.200000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.200000 1.000 1.000

0103082000 1CD Cassava 0.200000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.200000 1.000 1.000 0103139000 1CD Dasheen, corm 0.200000 1.000 1.000 0103166000 1CD Ginger 0.200000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.200000 1.000 1.000 0103167000 1CD Ginger, dried 0.200000 1.000 1.000
0103296000 1C Potato, chips 0.200000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.200000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.200000 6.500 1.000
0103298000 1C Potato, flour 0.200000 6.500 1.000 0103298001 1C Potato, flour

- babyfood 0.200000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.200000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.200000 1.000 1.00 0 0103300000 1C Potato, tuber, w/o peel 0.200000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.200000 1.000 1.000 0103366000 1CD Sweet potato 0.200000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.200000 1.000 1.000 0103371000 1CD Tanier, corm 0.200000 1.000 1.000

0103387000 1CD Turmeric 0.200000 1.000 1.000
0103406000 1CD Yam, true 0.200000 1.000 1.000

0103407000 1CD Yam bean 0.200000 1.000 1.000 0200051000 2 Beet, garden, tops 1.800000 1.000 1.000 0301165000 3A Garlic, bulb 0.100000 1.000 1. 000 0301165001 3A Garlic, bulb

- babyfood 0.100000 1.000 1.000 0301237000 3A Onion, bulb 0.100000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0.100000 1.000 1.000

0301238000 3A Oni on, bulb, dried 0.100000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 0.100000 9.000 1.000
0301338000 3A Shallot, bulb 0.100000 1.000 1.000 0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000

0302198000 3B Leek 2.000000 1.000 1.000 0302239000 3B Onion, green 2.000000 1.000 1.000
0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 19 of 24 0401204000 4A Lettuce, head 1.500000 1.000 1.000
0401205000 4A Lettuce, leaf 1.500000 1.000 1.000 0401355000 4A Spinach 0.500000 1.000 1.000

0401355001 4A S pinach

- babyfood 0.500000 1.000 1.000

0402076000 4B Cardoon 0.100000 1.000 1.000 0402085000 4B Celery 0.100000 1.000 1.000 0402085001 4B Celery

- babyfood 0.100000 1.000 1.000 0402086000 4B Celery, juice 0.100000 1.000 1.000

0402087000 4B Celtuce 0.100000 1.000 1.000
0402152000 4B Fennel, Florence 0.100 000 1.000 1.000

0402322000 4B Rhubarb 0.100000 1.000 1.000

0402367000 4B Swiss chard 0.100000 1.000 1.000

0501061000 5A Broccoli 0.600000 1.000 1.000

0501 061001 5A Broccoli

- babyfood 0.600000 1.000 1.000 0501062000 5A Broccoli, Chinese 0.600000 1.000 1.000 0501064000 5A Brussels sprouts 0.600000 1.000 1.000 0501069000 5A Cabbage 0.600000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.600000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 0.600000 1.000 1.000

0501083000 5A Cauliflower 0.6 00000 1.000 1.000

0501196000 5A Kohlrabi 0.600000 1.000 1.000

0502063000 5B Broccoli raab 1.800000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 1.800000 1.000 1.000

05 02117000 5B Collards 1.800000 1.000 1.000

0502194000 5B Kale 1.800000 1.000 1.000 0502229000 5B Mustard greens 1.800000 1.000 1.000 0502318000 5B Rape greens 1.800000 1.000 1.000 0502389000 5B Turnip, greens 1.800000 1.000 1.000 0600347000 6 Soybean, seed 0.300000 1.000 1.000 0600349000 6 Soybean, soy milk 0.300000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.300000 1.000 1.000 0600350000 6 Soybean, oil 0.300000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.300000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.300000 1.000 1.000 0601043001 6A Bean, snap, succulent

- babyfood 0.300000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 0.300000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.300000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.300000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.300000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.300000 1.000 1.000
0602255000 6B Pea, succulent 0.300000 1.000 1.000 0602255001 6B Pea, succulent

- babyfood 0.300000 1.000 1.000 0602259000 6B Pea, pi geon, succulent 0.300000 1.000 1.000 0603030000 6C Bean, black, seed 0.300000 1.000 1.000
0603032000 6C Bean, broad, seed 0.300000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.300000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.300000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.300000 1.000 1.000
0603038000 6C Bean, lima, seed 0.300000 1.000 1.00 0 0603039000 6C Bean, mung, seed 0.300000 1.000 1.000 0603040000 6C Bean, navy, seed 0.300000 1.000 1.000 0603041000 6C Bean, pink, seed 0.300000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.300000 1.000 1.000 0603098000 6C Chickpea, seed 0.300000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.300000 1.000 1.000 0603099000 6C Chickpea, flour 0.300000 1.000 1.000 0603182000 6C Guar, seed 0.300000 1.000 1.000
0603182001 6C Guar, seed

- babyfood 0.300000 1.000 1.000 0603203000 6C Lentil, seed 0.300000 1.000 1.000 0603256000 6C Pea, dry 0.300000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.300000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.300000 1.000 1.000 0603348000 6C Soybean, flour 0.300000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.300000 1.000 1.000

0801374000 8A Tomatillo 0.100000 1.000 1.000

0801375000 8A Tomato 0.100000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.100000 1.000 1.000 0801376000 8A Tomato, paste 0.300000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.300000 1.000 1.000 0801377000 8A Tomato, puree 0.100000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.100000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 20 of 24 0801378000 8A Tomato, dried 0.100000 14.300 1.00 0
0801378001 8A Tomato, dried

- babyfood 0.100000 14.300 1.000 0801379000 8A Tomato, juice 0.100000 1.500 1.000
0801380000 8A Tomato, Tree 0.100000 1.000 1.000 0802148000 8BC Eggplant 0.100000 1.000 1.000

0802234000 8BC Okra 0.500000 1.000 1.000 0802270000 8B Pepper, bell 0.100000 1.000 1.000 0802270001 8B Pepper, b ell

- babyfood 0.100000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.100000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.500000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.500000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.500000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000

0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000

0902021000 9B Balsam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.00 0 0902356001 9B Squash, summer

- babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000 1301055000 13A Blackberry 0.100000 1.000 1.000 1301056000 13A Blackberry, juice 0.100000 1.000 1.000 1301056001 13A Blackberry, juice

- babyfood 0.100000 1.000 1.000 1301058000 13A Boysenber ry 0.100000 1.000 1.000 1301208000 13A Loganberry 0.100000 1.000 1.000 1301320000 13A Raspberry 0.100000 1.000 1.000 1301320001 13A Raspberry

- babyfood 0.100000 1.000 1.000 1301321000 13A Raspberry, juice 0.100000 1.000 1.000 1301321001 13A Raspberry, juice

- babyfood 0.100000 1.000 1.000 1302057000 13B Blueberry 0.400000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.400000 1.000 1.000

1302136000 13B Currant 0.150000 1.000 1.000 1302137000 13B Currant, dried 0.150000 1.000 1.000

1302149000 13B Elderbe rry 0.150000 1.000 1.000 1302174000 13B Gooseberry 0.150000 1.000 1.000 1302191000 13B Huckleberry 0.150000 1.000 1.000 1307359000 13G Strawberry 0.400000 1.000 1.000 1307359001 13G Strawberry

- babyfood 0.400000 1.000 1.000 1307360000 13G Strawberry, juice 0.400000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 0.400000 1.000 1.00 0

1400003000 14 Almond 0.100000 1.000 1.000

1400003001 14 Almond

- babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000

1400004001 14 Almond, oil

- babyfood 0.100000 1.000 1.000

1400059000 14 Brazil nut 0.100000 1.000 1.000

1400068000 14 Butternut 0.100000 1.000 1.000

1400081000 14 Cashew 0.100000 1.000 1.000

1400092000 14 Chestnut 0.100000 1.000 1.000

1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Hazelnut, oil 0.100000 1.00 0 1.000 1400185000 14 Hickory nut 0.100000 1.000 1.000

1400213000 14 Macadamia nut 0.100000 1.000 1.000

1400269000 14 Pecan 0.100000 1.000 1.000

1400278000 14 Pine nut 0.100000 1.000 1.000

1400282000 14 Pistachio 0.100000 1.000 1.000

1400391000 14 Walnut 0.100000 1.000 1.000 1500025000 15 Barley, pearled barley 0.100000 1.000 1.000 1500025001 15 Barley, pearled barley

- babyfood 0.100000 1.000 1.000 1500026000 15 Barley, flour 0.100000 1.000 1.000 1500026001 15 Barley, flour

- babyfood 0.100000 1. 000 1.000 1500027000 15 Barley, bran 0.100000 1.000 1.000

1500065000 15 Buckwheat 0.100000 1.000 1.000
1500066000 15 Buckwheat, flour 0.100000 1.000 1.000

1500120000 1 5 Corn, field, flour 0.100000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 21 of 24 1500120001 15 Corn, field, flour

- babyfood 0.100000 1.000 1.000
1500121000 15 Corn, field, meal 0.100000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.100000 1.000 1.000 1500122000 15 Corn, field, bran 0.100000 1.000 1.000 1500123000 15 Corn, field, starch 0.100000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.000 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.100000 1.000 1.000 1500125000 15 Corn, field, oil 0.100000 1.000 1.000

1500125 001 15 Corn, field, oil

- babyfood 0.100000 1.000 1.000 1500126000 15 Corn, pop 0.100000 1.000 1.000
1500127000 15 Corn, sweet 0.100000 1.000 1.000 1500127001 15 Corn, sweet

- baby food 0.100000 1.000 1.000 1500226000 15 Millet, grain 0.100000 1.000 1.000
1500231000 15 Oat, bran 0.100000 1.000 1.000
1500232000 15 Oat, flour 0.1000 00 1.000 1.000 1500232001 15 Oat, flour

- babyfood 0.100000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.100000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.100000 1.000 1.000

15003 23000 15 Rice, white 0.100000 1.000 1.000 1500323001 15 Rice, white

- babyfood 0.100000 1.000 1.000 1500324000 15 Rice, brown 0.100000 1.000 1.000 1500324001 15 Rice, brown

- ba byfood 0.100000 1.000 1.000 1500325000 15 Rice, flour 0.100000 1.000 1.000
1500325001 15 Rice, flour

- babyfood 0.100000 1.000 1.000 1500326000 15 Rice, bran 0.100000 1.000 1.000
1500326001 15 Rice, bran

- babyfood 0.100000 1.000 1.000 1500328000 15 Rye, grain 0.100000 1.000 1.000 1500329000 15 Rye, flou r 0.100000 1.000 1.000 1500344000 15 Sorghum, grain 0.300000 1.000 1.000 1500345000 15 Sorghum, syrup 0.300000 1.000 1.000 1500381000 15 Triticale, flour 0.100000 1.000 1.000 1500381001 15 Triticale, flour

- babyfood 0.100000 1.000 1.000 1500401000 15 Wheat, grain 0.100000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.100000 1.000 1.000 1500402000 15 Wheat, flour 0.100000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.100000 1.000 1.000 1500403000 15 Wheat, germ 0.100000 1.000 1.000
1500404000 15 Wheat, bran 0.100000 1.000 1.000

1500405000 15 Wild rice 0.100000 1.000 1.000
1901118000 19A Cilantro, leaves 8.000000 1.000 1.000 1901118001 19A Cilantro, leaves

- babyfood 8.000000 1.000 1.000

1901144000 19A Dillweed 0.500000 1.000 1.000 1902119000 19B Coriander, seed 0.130000 1.000 1.000
1902119001 19B Coriander, seed

- babyfood 0.130000 1.000 1.00 0 2001336000 20A Sesame, seed 0.130000 1.000 1.000
2001336001 20A Sesame, seed

- babyfood 0.130000 1.000 1.000 2001337000 20A Sesame, oil 0.130000 1.000 1.000

2001337001 20A Sesame, oil

- babyfood 0.130000 1.000 1.000 2002330000 20B Safflower, oil 0.500000 1.000 1.000 2002330001 20B Safflower, oil

- babyfood 0.500000 1.000 1.000
2002364000 20B Sunflower, seed 0.500000 1.000 1.000 2002365000 20B Sunflower, oil 0.500000 1.000 1.000
2002365001 20B Sunflower, oil

- babyfood 0.500000 1.000 1.000 2003128000 20C Cottonseed, oil 0.100000 1.00 0 1.000 2003128001 20C Cottonseed, oil

- babyfood 0.100000 1.000 1.000 3100044000 31 Beef, meat 0.020000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.020000 1.000 1.000

3100045000 31 Beef, meat, dried 0.020000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.040000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.040000 1.000 1.000
3100047000 31 Beef, fat 0.020000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 0.050000 1. 000 1.000 3100049001 31 Beef, liver

- babyfood 0.050000 1.000 1.000 3200169000 32 Goat, meat 0.020000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.040000 1.000 1.000

3200171000 3 2 Goat, fat 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 0.050000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 22 of 24 3300189000 33 Horse, meat 0.020000 1.000 1.000 3500339000 35 Sheep, meat 0.020000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.020000 1.000 1.000 3500340000 35 Sheep, me at byproducts 0.040000 1.000 1.000 3500341000 35 Sheep, fat 0.020000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 0.050000 1.000 1.000 3600222000 36 Milk, fat 0.020000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.020000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.020000 1.000 1.000
3600224000 36 Milk, water 0.020000 1.000 1.000
3600224001 36 Milk, w ater

- babyfood/infant form 0.020000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.020000 1.000 1.000
3800221000 38 Meat, game 0.020000 1.000 1.000 3900312000 39 Rabbit, meat 0.020000 1.000 1.000 4000093000 40 Chicken, meat 0.020000 1.000 1.000 4000093001 40 Chicken, meat

- babyfood 0.020000 1.000 1.000 4000094000 40 Chicken, liver 0.050000 1.000 1.00 0 4000095000 40 Chicken, meat byproducts 0.050000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.050000 1.000 1.000 4000096000 40 Chicken, fat 0.020000 1.000 1.000

4000096001 40 Chicken, fat

- babyfood 0.020000 1.000 1.000 4000097000 40 Chicken, skin 0.050000 1.000 1.000 4000097001 40 Chicken, skin

- babyfood 0.050000 1.000 1.000 5000382000 50 Turkey, meat 0.020000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.020000 1.000 1.000 5000383000 50 Turkey, liver 0.050000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.050000 1.00 0 1.000 5000384000 50 Turkey, meat byproducts 0.050000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.050000 1.000 1.000 5000385000 50 Turkey, fat 0.020000 1.000 1.000

5000385001 50 Turkey, fat

- babyfood 0.020000 1.000 1.000 5000386000 50 Turkey, skin 0.050000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.050000 1.000 1.000 6000301000 60 Poultry, other, meat 0.020000 1.000 1.000 6000302000 60 Poultry, other, liver 0.050000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.050000 1.000 1.000 6000304000 60 Poultry, other, fat 0.020000 1. 000 1.000 6000305000 60 Poultry, other, skin 0.050000 1.000 1.000 7000145000 70 Egg, whole 0.020000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.020000 1.000 1.000

7000146000 7 0 Egg, white 0.020000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.020000 1.000 1.000 7000147000 70 Egg, yolk 0.020000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.043700 1.000 1.000
8602000000 86B Water, indirect, all sources 0.043700 1.000 1.000 9500019000 O Asparagus 0.100000 1.000 1.000

9500263000 O Peanut 0.200000 1.000 1.000
9500264000 O Peanut, butter 0.200000 1.890 1.000 9500265000 O Peanut, oil 0.200000 1.000 1.000S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 23 of 24 

### Attachment 4 Results of Chronic DEEM

- FCID Dietary Exposure Analysis

Food and Water

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for S

- METOLACHLOR AND METOLACHLOR

NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 108800 s

- Metolachlor \ 108800 Chronic Food plus Water.r08 Adj ustment factor #2 NOT used. Analysis Date 01

- 22

- 2015/10:47:30 Residue file dated: 01

- 22

- 2015/10:46:05 Reference dose (RfD, Chronic) = .097 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

--------- -------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- -------------- -- Total US Population 0.003008 3.1% Hispanic 0.002977 3.1%

Non

- Hisp

- White 0.003039 3.1%

Non

- Hisp

- Black 0.002660 2.7%

Non

- Hisp

- Other 0.003509 3.6% Nursing Infants 0.002830 2.9%

Non

- Nursing Infants 0.006912 7.1%

Female 13+ PREG 0.002782 2.9%

Children 1

- 6 0.005774 6.0%

Children 7

- 12 0.003487 3.6%

Male 13

- 19 0.002427 2.5%

Female 13

- 19/NP 0.002390 2.5%

Male 20+ 0.002566 2.6% Female 20+/NP 0.002758 2.8%

Seniors 55+ 0.002610 2.7%

All Infants 0.005652 5.8%

Female 13

- 50 0.002682 2.8%

Children 1

- 2 0.006557 6.8%

Children 3

- 5 0.005513 5.7%

Children 6

- 12 0.003690 3.8%

Youth 13

- 19 0.002407 2.5%

Adults 20

- 49 0.002687 2.8%

Adults 50

- 99 0.002644 2.7%

Female 13

- 49 0.002687 2.8%

------------ -------------------------------------------------------------------S

- Metolachlor Dietary Exposure and Risk Assessment DP # D 425169

Page 24 of 24 

### Food Only

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for S

- METOLACHLOR AND METOLACHLOR

NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 108800 s

- Metolachlor \ 108800 Chronic Food Only.r08 Adjustmen t factor #2 NOT used. Analysis Date 01

- 22

- 2015/10:47:02 Residue file dated: 01

- 22

- 2015/10:45:46 Reference dose (RfD, Chronic) = .097 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.002093 2.2% Hispanic 0.002104 2.2%

Non

- Hisp

- White 0.002098 2.2%

Non

- Hisp

- Black 0.001905 2.0%

Non

- Hisp

- Other 0.002454 2.5% Nursing Infants 0.002002 2.1%

Non

- Nursing Infants 0.003869 4.0%

Female 13+ PREG 0.001921 2.0%

Children 1

- 6 0.004602 4.7%

Children 7

- 12 0.002724 2.8%

Male 13

- 19 0.00179 8 1.9%

Female 13

- 19/NP 0.001685 1.7%

Male 20+ 0.001714 1.8% Female 20+/NP 0.001797 1.9%

Seniors 55+ 0.001725 1.8%

All Infants 0.003292 3.4%

Female 13

- 50 0.001771 1.8%

Children 1

- 2 0 .005237 5.4%

Children 3

- 5 0.004401 4.5%

Children 6

- 12 0.002888 3.0%

Youth 13

- 19 0.001740 1.8%

Adult s 20

- 49 0.001774 1.8%

Adults 50

- 99 0.001742 1.8%

Female 13

- 49 0.001777 1.8%

-------------------------------------- -----------------------------------------