EX-10.2




 Exhibit 10.2 

Execution Version 

LOAN AND SECURITY AGREEMENT 

THIS LOAN AND SECURITY AGREEMENT is made and dated as of November 1, 2022 (as amended, restated, amended and restated, supplemented or
otherwise modified from time to time, this “Agreement”) and is entered into by and among Kura Oncology, Inc., a Delaware corporation, and each of its Subsidiaries from time to time party hereto (hereinafter collectively referred to as
“Borrower”), the several banks and other financial institutions or entities from time to time parties to this Agreement (collectively, referred to as the “Lenders”) and HERCULES CAPITAL, INC., a Maryland corporation, in its
capacity as administrative agent and collateral agent for itself and the Lenders (in such capacity, the “Agent”). 
 RECITALS

 A. Borrower has requested the Lenders make available to Borrower a loan in an aggregate principal amount of up to One Hundred
Twenty-Five Million Dollars ($125,000,000) (the “Term Loan”); and 
 B. The Lenders are willing to make the Term Loan on the terms
and conditions set forth in this Agreement. 
 AGREEMENT 

NOW, THEREFORE, Borrower, Agent and the Lenders agree as follows: 

SECTION 1. DEFINITIONS AND RULES OF CONSTRUCTION 

1.1 Unless otherwise defined herein, the following capitalized terms shall have the following meanings: 

“Account Control Agreement(s)” means any agreement entered into by and among the Agent, Borrower and a third party bank or other
institution (including a Securities Intermediary) in which Borrower maintains a Deposit Account or an account holding Investment Property and which perfects Agent’s first priority security interest in the subject account or accounts. 

“ACH Authorization” means the ACH Debit Authorization Agreement in substantially the form of Exhibit H, which account numbers shall
be redacted for security purposes if and when filed publicly by Borrower. 
 “Acquisition” means any transaction or series of
related transactions for the purpose of or resulting, directly or indirectly, in (a) the acquisition of all or substantially all of the assets of a Person, or of any business, line of business or division or other unit of operation of a Person,
(b) the acquisition of fifty percent (50%) or more of the Equity Interests of any Person, whether or not involving a merger, consolidation or similar transaction with such other Person, or otherwise causing any Person to become a Subsidiary of
Borrower, or (c) the acquisition of, or the right to use, develop or sell (in each case, including through any exclusive license), any product, product line or Intellectual Property of or from any other Person. 

“Advance(s)” means a Term Loan Advance. 

“Advance Date” means the funding date of any Advance. 











 “Advance Request” means a request for an Advance submitted by Borrower to Agent in
substantially the form of Exhibit A, which account numbers shall be redacted for security purposes if and when filed publicly by Borrower. 

“Affiliate” means (a) any Person that directly or indirectly controls, is controlled by, or is under common control with the
Person in question, (b) any Person directly or indirectly owning, controlling or holding with power to vote twenty percent (20%) or more of the outstanding voting securities of another Person, or (c) any Person twenty percent (20%) or more
of whose outstanding voting securities are directly or indirectly owned, controlled or held by another Person with power to vote such securities. As used in the definition of “Affiliate,” the term “control” means the possession,
directly or indirectly, of the power to direct or cause the direction of the management and policies of a Person, whether through ownership of voting securities, by contract or otherwise. 

“Agreement” means this Loan and Security Agreement, as amended, restated, amended and restated, supplemented or otherwise modified
from time to time. 
 “Amortization Date” means November 1, 2024; provided however, (i) if the Interest Only
Milestone 1 Conditions are satisfied, then May 1, 2025, (ii) if the Interest Only Milestone 2 Conditions are satisfied, then November 1, 2025, and (iii) if Borrower has achieved the Approval Milestone, then November 1, 2026. 

“Anti-Corruption Laws” means all laws, rules, and regulations of any jurisdiction applicable to Borrower or any of its Affiliates
from time to time concerning or relating to bribery or corruption, including without limitation the United States Foreign Corrupt Practices Act of 1977, as amended, the UK Bribery Act 2010 and other similar legislation in any other jurisdictions.

 “Anti-Terrorism Laws” means any laws, rules, regulations or orders relating to
terrorism or money laundering, including without limitation Executive Order No. 13224 (effective September 24, 2001), the USA PATRIOT Act, the laws comprising or implementing the Bank Secrecy Act, and the laws administered by OFAC. 

“Approval Milestone” means Borrower shall have obtained approval of the NDA for Ziftomenib from the FDA, with an approved label that
is generally consistent with the label sought in Borrower’s NDA, subject to reasonable verification by Agent (including any supporting documentation requested by Agent). 

“Blocked Person” means any Person: (a) listed in the annex to, or is otherwise subject to the provisions of, Executive Order
No. 13224, (b) a Person owned or controlled by, or acting for or on behalf of, any Person that is listed in the annex to, or is otherwise subject to the provisions of, Executive Order No. 13224, (c) a Person with which any Lender is
prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism Law, (d) a Person that commits, threatens or conspires to commit or supports “terrorism” as defined in Executive Order No. 13224, or
(e) a Person that is named a “specially designated national” or “blocked person” on the most current list published by OFAC or other similar list. 

“Borrower Products” means all products, software, service offerings, technical data or technology currently being designed,
manufactured or sold by Borrower or which Borrower intends to sell, license, or distribute in the future including any products or service offerings under development, collectively, together with all products, software, service offerings, technical
data or technology that have been sold, licensed or distributed by Borrower since its incorporation. 











 “Borrower’s Books” means Borrower’s or any of its Subsidiaries’
books and records including ledgers, federal, state, local and foreign tax returns, records regarding Borrower’s or its Subsidiaries’ assets or liabilities, the Collateral, business operations or financial condition, and all computer
programs or storage or any equipment containing such information. 
 “Borrower’s Market Capitalization” means, for any given
date of determination, an amount equal to (a) the average of the daily volume weighted average price of Common Stock as reported for each the five (5) trading days preceding such date of determination (it being understood that a
“trading day” shall mean a day on which shares of Common Stock trade on the NASDAQ in an ordinary trading session) multiplied by (b) the total number of issued and outstanding shares of Common Stock that are issued and outstanding on
the date of the determination and listed on the NASDAQ. Such determination shall be appropriately adjusted for any stock dividend, stock split, stock combination, reclassification or other similar transaction during the applicable calculation
period. 
 “Business Day” means any day other than Saturday, Sunday and any other day on which banking institutions in the State
of California are closed for business. 
 “Cash” means all cash, cash equivalents and liquid funds. 

“Change in Control” means any event, transaction, or occurrence as a result of which any “person” (as such term is defined
in Sections 3(a)(9) and 13(d)(3) of the Exchange Act), other than a trustee or other fiduciary holding securities under an employee benefit plan of Borrower, is or becomes a beneficial owner (within the meaning Rule
13d-3 promulgated under the Exchange Act), directly or indirectly, of securities of Borrower, representing forty-nine percent (49%) or more of the combined voting power of Borrower’s then outstanding
securities. In addition, the occurrence of any “change of control”, “fundamental change”, “make-whole fundamental change” or any comparable term under and as defined in any indenture governing any Permitted Convertible
Debt shall constitute a “Change in Control”. 
 “Closing Date” means the date of this Agreement. 

“Code” means the Internal Revenue Code of 1986, as amended. 

“Common Stock” means the common stock, par value $0.0001 per share, of Kura Oncology. 

“Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that Person
with respect to (i) any Indebtedness, capital lease, dividend, letter of credit or other obligation of another, including any such obligation directly or indirectly guaranteed, endorsed, co-made or
discounted or sold with recourse by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit, corporate credit cards or merchant services issued
for the account of that Person; and (iii) all obligations arising under any Hedging Agreement; provided, however, that the term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course of
business. The amount of any Contingent Obligation shall be deemed, without duplication of the primary obligation, to be an amount equal to the stated or determined amount of the primary obligation in respect of which such Contingent Obligation is
made or, if not stated or determinable, the maximum reasonably anticipated liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in any event exceed the maximum amount of the
obligations under the guarantee or other support arrangement. For the avoidance of doubt, no Permitted Bond Hedge Transaction or Permitted Warrant Transaction will be considered a Contingent Obligation of Borrower. 











 “Copyright License” means any written agreement granting any right to use any
Copyright or Copyright registration, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 

“Copyrights” means all copyrights, whether registered or unregistered, held pursuant to the laws of the United States of
America, any State thereof, or of any other country. 
 “Corporate Collaborations” means any corporate collaborations, including
without limitation: cost-sharing arrangements with collaborative partners, collaborative work on manufacturing process improvements and academic or development collaborations for discovery research projects, arrangements with contract research
organizations, preclinical work, animal studies or investigator-sponsored clinical trials or proof of concept studies. 

“Cross-Default Reference Obligation” has the meaning assigned to such term in the definition of “Permitted Convertible
Debt”. 
 “Default” means any event, circumstance or condition that has occurred or exists, that would, with the passage of
time or the requirement that notice be given or both, become an Event of Default. 
 “Deposit Accounts” means any “deposit
accounts,” as such term is defined in the UCC, and includes any checking account, savings account, or certificate of deposit. 

“Disclosure Letter” means that certain letter, dated the date hereof, delivered by Borrower to Agent. 

“Disqualified Equity Interests” means any Equity Interests that, by their terms (or by the terms of any security or other Equity
Interests into which they are convertible or for which they are exchangeable), or upon the happening of any event or condition (a) mature or are mandatorily redeemable (other than solely for Qualified Equity Interests) pursuant to a sinking
fund obligation or otherwise on or prior to one hundred eighty (180) days following the Term Loan Maturity Date at the time such Equity Interests are issued (it being understood that if any such redemption is in part, only such part coming into
effect prior to one hundred eighty (180) days following the Term Loan Maturity Date shall constitute Disqualified Equity Interests) (except as a result of a change of control or asset sale so long as any rights of the holders thereof upon the
occurrence of a change of control or asset sale event shall be subject to the prior repayment in full of the Secured Obligations), (b) are redeemable at the option (except as a result of a change of control or asset sale so long as any rights of the
holders thereof upon the occurrence of a change of control or asset sale event shall be subject to the prior repayment in full of the Secured Obligations) of the holder thereof (other than solely for Qualified Equity Interests), in whole or in part,
on or prior to one hundred eighty (180) days following the Term Loan Maturity Date at the time such Equity Interests are issued, (c) provide for scheduled payments of dividends in cash or cash equivalents on or prior to one hundred eighty
(180) days following the Term Loan Maturity Date at the time such Equity Interests are issued, or (d) are or become convertible into or exchangeable for Indebtedness or any other Equity Interests that would constitute Disqualified Equity
Interests, in each case, prior to the date that is one hundred eighty (180) days after the Term Loan Maturity Date. 
 “Domestic
Subsidiary” means any Subsidiary organized under the laws of the United States of America, any State thereof, the District of Columbia, or any other jurisdiction within the United States of America. 











 “Due Diligence Fee” means $50,000, which fee has been paid to the Lenders prior to
the Closing Date, and shall be deemed fully earned on such date regardless of the early termination of this Agreement. 
 “Equity
Interests” means, with respect to any Person, the capital stock, partnership or limited liability company interest, or other equity securities or equity ownership interests of such Person. 

“ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the regulations promulgated thereunder. 

“Excluded Accounts” means (i) any Deposit Account that is used solely as a payroll account for the employees of Borrower or any
of its Subsidiaries or the funds in which consist solely of funds held in trust for any director, officer or employee of such Borrower or Subsidiary or any employee benefit plan maintained by such Borrower or Subsidiary or funds representing
deferred compensation for the directors and employees of such Borrower or Subsidiary, collectively not to exceed 200% of the amount to be paid in the ordinary course of business in the then-next payroll cycle (including, without limitation, any
bonus payments), (ii) escrow accounts, trust accounts, restricted cash accounts and other Deposit Accounts or Securities Accounts, in each case holding assets that are pledged or otherwise encumbered by Permitted Liens (but only to the extent
required to be excluded pursuant to the underlying documents entered into in connection with such Permitted Liens in the ordinary course of business), (iii) accounts containing no (zero) balance so long as the balance in each such account is swept
no less frequently than once every Business Day into a Deposit Account subject to an Account Control Agreement, or (iv) any Deposit Account with a balance less than $750,000; provided, that the aggregate balance of all such Deposit Accounts
excluded pursuant to this clause (iv) shall at no time exceed $750,000. 
 “FDA” means the U.S. Food and Drug Administration
or any successor thereto. 
 “FDCA” means the Federal Food, Drug, and Cosmetic Act, 21 U.S.C. § 301 et seq., as amended from
time to time, and the rules and regulations promulgated thereunder. 
 “Foreign Subsidiary” means any Subsidiary other than a
Domestic Subsidiary. 
 “GAAP” means generally accepted accounting principles in the United States of America, as in effect from
time to time. 
 “Healthcare Laws” means all health care laws applicable to Borrower or any Subsidiary and to the ownership,
testing, development, sale, marketing, manufacture, packaging, processing, use, distribution, storage, import, export or disposal of Borrower’s or any Subsidiary’s products or product candidates, including but not limited to, the FDCA, the
Anti-Kickback Statute (42 U.S.C. Section 1320a-7b(b)), the Civil Monetary Penalties Law (42 U.S.C. § 1320a-7a), the Physician Payment Sunshine Act (42 U.S.C.
§ 1320a-7h), the Civil False Claims Act (31 U.S.C. Section 3729 et seq.), the criminal False Claims Law (42 U.S.C. § 1320a-7b(a)), all criminal laws
relating to health care fraud and abuse, including but not limited to 18 U.S.C. Sections 286 and 287, and the health care fraud criminal provisions under HIPAA (42 U.S.C. Section 1320d et seq.), the exclusion laws (42 U.S.C. § 1320a-7), HIPAA and similar state and foreign privacy and data security laws such as the European Union General Data Protection Regulation, Medicare (Title XVIII of the Social Security Act), Medicaid (Title XIX of
the Social Security Act), and any and all other comparable state, local, federal or foreign health care laws and the regulations promulgated pursuant to such laws, each as amended from time to time. 

“Hedging Agreement” means any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar
agreement, or other agreement or arrangement designated to 











 
protect Borrower or its Subsidiaries against fluctuation in interest rates, currency exchange rates or commodity price. 

“HIPAA” means the U.S. Health Insurance Portability and Accountability Act of 1996 (42 U.S.C. § 1320d et seq.) as amended by
the Health Information Technology for Economic and Clinical Health Act (42 U.S.C. § 17921 et seq.), and all regulations promulgated thereunder. 

“IND” means an investigational new drug application submitted to the FDA pursuant to 21 C.F.R. § 312 for allowance to initiate
human clinical trials in the United States, including all amendments that may be filed or submitted thereto. 
 “Indebtedness”
means indebtedness of any kind, including (a) all indebtedness for borrowed money or the deferred purchase price of property or services (excluding trade credit entered into in the ordinary course of business due within one-hundred twenty (120) days), including reimbursement and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar
instruments, (c) all capital lease obligations, (d) Disqualified Equity Interests, (e) “earnouts”, deferred purchase price and similar payment obligations or continuing obligations of any nature arising out of purchase and sale
contracts (excluding any contingent or performance-based milestones, earnouts, or royalties), and (f) all Contingent Obligations. For the avoidance of doubt no Permitted Warrant Transaction shall be considered Indebtedness of Borrower. 

“Initial Facility Charge” means One Hundred Twenty Five Thousand Dollars ($125,000.00), which is payable to the Lenders in
accordance with Section 4.1(f). 
 “Insolvency Proceeding” means any proceeding by or against any Person under the United
States Bankruptcy Code, or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other similar
relief. 
 “Intellectual Property” means all of Borrower’s Copyrights; Trademarks; Patents; Licenses; trade secrets and
inventions; mask works; Borrower’s applications therefor and reissues, extensions, or renewals thereof; and Borrower’s goodwill associated with any of the foregoing, together with Borrower’s rights to sue for past, present and future
infringement of Intellectual Property and the goodwill associated therewith. 
 “Interest Only Milestone 1 Conditions” shall mean
satisfaction of each of the following events, subject to reasonable verification by Agent: (a) no Default or Event of Default shall have occurred; (b) satisfaction of the Tranche 2 Milestone; and (c) Borrower has closed an arm’s
length strategic partnership transaction permitted hereunder relating to Borrower’s core Intellectual Property, in which Borrower receives unrestricted (including, not subject to any redemption, clawback, escrow or similar encumbrance or
restriction) upfront net proceeds of at least Twenty Million Dollars ($20,000,000) in the period between October 13, 2022 and October 15, 2024, in each case subject to reasonable verification by Agent (including any supporting
documentation requested by Agent). 
 “Interest Only Milestone 2 Conditions” shall mean satisfaction of each of the following
events, subject to reasonable verification by Agent: (a) no Default or Event of Default shall have occurred; (b) satisfaction of the Interest Only Milestone 1 Conditions; (c) Borrower has announced Positive Clinical Data from the KOMET-001 registration-enabling trial evaluating Ziftomenib for the treatment of patients with acute myeloid leukemia; and (d) the FDA has accepted for filing an NDA submission seeking approval for Ziftomenib,
in each case subject to reasonable verification by Agent (including any supporting documentation requested by Agent). 











 “Investment” means (a) any beneficial ownership (including stock,
partnership, limited liability company interests, or other securities) of or in any Person, (b) any loan, advance or capital contribution to any Person, or (c) any Acquisition. 

“IRS” means the United States Internal Revenue Service. 

“Joinder Agreements” means for each Subsidiary, a completed and executed Joinder Agreement in substantially the form attached hereto
as Exhibit F. 
 “KO-2806” means Borrower’s next-generation farnesyl transferase
inhibitor product candidate KO-2806. 
 “Kura Oncology” means Kura Oncology, Inc., a
Delaware corporation. 
 “License” means any Copyright License, Patent License, Trademark License or other license of rights or
interests. 
 “Lien” means any mortgage, deed of trust, pledge, hypothecation, assignment for security, security interest,
encumbrance, levy, lien or charge of any kind, whether voluntarily incurred or arising by operation of law or otherwise, against any property, any conditional sale or other title retention agreement, and any lease in the nature of a security
interest. 
 “Loan” means the Advances made under this Agreement. 

“Loan Documents” means this Agreement, the promissory notes (if any), the ACH Authorization, the Account Control Agreements, the
Joinder Agreements, all UCC financing statements, the Warrant and any other documents executed in connection with the Secured Obligations or the transactions contemplated hereby, as the same may from time to time be amended, modified, supplemented
or restated. 
 “Material Adverse Effect” means a material adverse effect upon: (i) the business, operations, properties,
assets or financial condition of Borrower and its Subsidiaries taken as a whole; or (ii) the ability of Borrower to perform or pay the Secured Obligations in accordance with the terms of the Loan Documents, or the ability of Agent or the
Lenders to enforce any of its rights or remedies with respect to the Secured Obligations; or (iii) the Collateral or Agent’s Liens on the Collateral or the priority of such Liens. 

“Maximum Term Loan Amount” means One Hundred Twenty-Five Million and No/100 Dollars ($125,000,000.00). 

“NDA” means (i) a new drug application submitted to the FDA pursuant to 21 U.S.C. § 355 seeking authorization to market a
new drug in the United States and (ii) all supplements and amendments that may be filed or submitted thereto. 
 “Non-Core Intellectual Property” means any Intellectual Property not material to Borrower’s business upon prior consultation with Agent. For the avoidance of doubt, any Intellectual Property related
to or in connection with Ziftomenib, Tipifarnib and KO-2806 shall not constitute Non-Core Intellectual Property. 

“OFAC” means the U.S. Department of Treasury Office of Foreign Assets Control. 











 “OFAC Lists” mean, collectively, the Specially Designated Nationals and Blocked
Persons List maintained by OFAC pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) and/or any other list of terrorists or other restricted Persons maintained pursuant to any of the rules and regulations of OFAC or
pursuant to any other applicable Executive Orders. 
 “Patent License” means any written agreement granting any right with respect
to any invention on which a Patent is in existence or a Patent application is pending, in which agreement Borrower now holds or hereafter acquires any interest. 

“Patents” means all letters patent of, or rights corresponding thereto, in the United States of America or in any other country, all
registrations and recordings thereof, and all applications for letters patent of, or rights corresponding thereto, in the United States of America or any other country. 

“Permits” means all certifications, registrations, licenses, permits, franchises, approvals, clearances, exemptions, authorizations
or consents of any governmental entity, necessary for or used in the conduct or operation Borrower’s or any Subsidiary’s business. 

“Permitted Acquisition” means (a) the Acquisition described on Schedule 1B(ii) of the Disclosure Letter with an aggregate cash
consideration not to exceed $25,000,000 and (b) any Acquisition (including Corporate Collaborations constituting Acquisitions), which is conducted in accordance with the following requirements: 

(i) of a business or Person or product engaged in a line of business similar, related or complementary to that of Borrower or its
Subsidiaries; 
 (ii) if such Acquisition is structured as a stock acquisition, then the Person so acquired shall either (i) become a
wholly-owned Subsidiary of Borrower or of a Subsidiary and Borrower shall comply, or cause such Subsidiary to comply, with 7.13 hereof or (ii) such Person shall be merged with and into Borrower (with Borrower being the surviving entity); 

(iii) if such Acquisition is structured as the acquisition or in-licensing of assets, such assets
shall be acquired by Borrower, and shall be free and clear of Liens other than Permitted Liens; 
 (iv) Borrower shall have delivered to the
Lenders not less than fifteen (15) nor more than forty five (45) days prior to the date of such Acquisition, notice of such Acquisition together with pro forma projected financial information (to the extent available), copies of
then-current drafts of all material documents relating to such acquisition, and historical financial statements (to the extent available) for such acquired entity, division or line of business, in each case in form and substance reasonably
satisfactory to the Lenders and demonstrating compliance with the covenants set forth in Section 7.19 hereof on a pro forma basis as if the Acquisition occurred on the first day of the most recent measurement period; 

(v) both immediately before and after such Acquisition no Default or Event of Default shall have occurred and be continuing; and 

(vi) the aggregate cash consideration paid or payable in respect of such Acquisition (excluding any contingent or performance-based
milestones, earnouts, or royalties), together with all other Permitted Acquisitions made during the term of this Agreement, shall not be greater than Ten Million Dollars ($10,000,000); provided, that, for the avoidance of doubt, the
remainder of such purchase price may be paid in Equity Interests of the Borrower or the net cash proceeds of any substantially concurrent offering of Equity Interests of the Borrower, in each case, to the extent permitted hereunder. 











 “Permitted Bond Hedge Transaction” means any call or capped call option (or
substantively equivalent derivative transaction) relating to the Common Stock (or other securities or property following a merger event or other change of the Common Stock) purchased by Borrower in connection with the issuance of any Permitted
Convertible Debt and as may be amended in accordance with its terms; provided that the net purchase price of any such call option transaction less the amount received by Borrower in respect of any Permitted Warrant Transaction in connection
with such issuance of Permitted Convertible Debt shall not exceed fifteen percent (15%) of the gross proceeds to Borrower from such issuance of Permitted Convertible Debt; provided further that terms, conditions and covenants of each such
call option transaction are customary for agreements of such type, as determined in good faith by the Borrower. 
 “Permitted
Convertible Debt” means Indebtedness of Borrower that is convertible into a fixed number (subject to customary anti-dilution adjustments, “make-whole” increases and other customary changes thereto), at the option of the holders
thereof, of shares of Common Stock (or other securities or property following a merger event or other change of the Common Stock), cash or any combination thereof; provided that such Indebtedness shall (a) not require any scheduled
amortization or otherwise require payment of principal prior to, or have a scheduled maturity date, earlier than, ninety-one (91) days after the Term Loan Maturity Date (other than the requirement to
deliver consideration in satisfaction of conversions), (b) be (i) unsecured or (ii) (A) expressly subordinated to the Secured Obligations pursuant to market standard subordination terms for underwritten offerings of senior subordinated
convertible notes and (B) specifically designate this Agreement and all Secured Obligations as “designated senior indebtedness” or similar term so that the subordination terms referred to in the preceding clause (A) specifically
refer to such notes as being subordinated to the Secured Obligations pursuant to such subordination terms, (c) be on terms and conditions customary for Indebtedness of such type, as determined in good faith by the Borrower, and (d) not be
guaranteed by any Subsidiary of Borrower that has not executed a joinder; provided further, that any cross-default or cross-acceleration event of default (each howsoever defined) provision contained therein that relates to indebtedness
or other payment obligations of Borrower (or any of its Subsidiaries) (such indebtedness or other payment obligations, a “Cross-Default Reference Obligation”) contains a cure period of at least thirty (30) calendar days (after written
notice to the issuer of such Indebtedness by the trustee or to such issuer and such trustee by holders of at least 25% in aggregate principal amount of such Indebtedness then outstanding) before a default, event of default, acceleration or other
event or condition under such Cross-Default Reference Obligation results in an event of default under such cross-default or cross-acceleration provision. 

“Permitted Indebtedness” means: 

(i) Indebtedness of Borrower in favor of the Lenders or Agent arising under this Agreement or any other Loan Document; 

(ii) Indebtedness existing on the Closing Date which is disclosed in Schedule 1A to the Disclosure Letter; 

(iii) Indebtedness of up to Five Hundred Thousand Dollars ($500,000) outstanding at any time secured by a Lien described in
clause (vii) of the defined term “Permitted Liens,” provided such Indebtedness does not exceed the cost of the Equipment or software or other intellectual property financed with such Indebtedness; 

(iv) Indebtedness to trade creditors incurred in the ordinary course of business (due within
one-hundred twenty (120) days), including such Indebtedness incurred in the ordinary course of business with corporate credit cards, purchase cards and debit cards and other similar instruments in an
amount not to exceed One Million Dollars ($1,000,000) at any time outstanding; 











 (v) Indebtedness that also constitutes a Permitted Investment or is secured
by a Permitted Lien, and Indebtedness consisting of obligations under deferred or contingent consideration arrangements (including, without duplication, earn-outs, milestone payments, royalties and other contingent or deferred obligations as long as
such obligations are not evidenced by any “seller notes” or similar Indebtedness in connection with Permitted Acquisitions); 

(vi) Subordinated Indebtedness; 

(vii) reimbursement obligations in connection with letters of credit that are secured by Cash and issued on behalf of Borrower
or a Subsidiary thereof in an amount not to exceed Five Hundred Thousand Dollars ($500,000) at any time outstanding, 

(viii) other Indebtedness in an amount not to exceed One Million Dollars ($1,000,000) at any time outstanding, 

(ix) intercompany Indebtedness as long as each of the obligor and the obligee under such Indebtedness is the Borrower or a
Subsidiary that has executed a Joinder Agreement; 
 (x) Permitted Convertible Debt not to exceed Two Hundred Fifty Million
Dollars ($250,000,000) in aggregate principal amount at any one time outstanding; 
 (xi) Indebtedness with respect to a
Permitted Royalty Transaction that (a) is subordinated to the Secured Obligations pursuant to a subordination or intercreditor agreement on terms and conditions reasonably satisfactory to Agent, (b) does not have a scheduled maturity date
earlier than one hundred eighty (180) days after the Term Loan Maturity Date, and (c) is in an aggregate amount not less than Fifty Million Dollars ($50,000,000); 

(xii) Licenses permitted pursuant to the definition of Permitted Transfers or otherwise permitted hereunder, solely to the
extent involving the incurrence of Indebtedness; 
 (xiii) Guarantees of the obligations of suppliers, customers and
licensees of the Borrower incurred to third parties for the purpose of enabling such suppliers, customers and licensees to purchase products that will be supplied, or incorporated into products that will be supplied, to the Borrower by such
suppliers, customers or licensees, in an amount not to exceed One Million Dollars ($1,000,000) in the aggregate; 
 (xiv)
Financing of insurance premiums in the ordinary course of business; 
 (xv) Advances or deposits received in the ordinary
course of business from customers or vendors; 
 (xvi) Indebtedness with respect to performance bonds, appeal bonds and other
similar obligations, in an aggregate amount not to exceed $500,000 at any time outstanding; 
 (xvii) Indebtedness incurred
as a result of endorsing negotiable instruments received in the ordinary course of business; 
 (xviii) obligations under any
Hedging Agreement incurred for bona-fide risk management purposes in the ordinary course of business and not for speculative purposes; 











 (xix) Indebtedness assumed pursuant to any Permitted Acquisition; provided
that (i) no such Indebtedness shall exceed 10% of the total purchase price paid in connection with such Permitted Acquisition, (ii) the aggregate outstanding principal amount of Indebtedness permitted pursuant to this clause
(xx) shall not exceed $1,000,000 at any time outstanding and (iii) no such Indebtedness was created or incurred in connection with, or in contemplation of, such Permitted Acquisition; or 

(xx) extensions, refinancings and renewals of any items of Permitted Indebtedness, provided that the principal amount is not
increased or the terms modified to impose materially more burdensome terms upon the Borrower or its Subsidiary, as the case may be. 

“Permitted Investment” means: 

(i) Investments existing on the Closing Date which are disclosed in Schedule 1B(i) to the Disclosure Letter; 

(ii) (a) marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or
any State thereof maturing within one year from the date of acquisition thereof currently having a rating of at least A-2 or P-2 from either Standard &
Poor’s Corporation or Moody’s Investors Service, (b) commercial paper maturing no more than one year from the date of creation thereof and currently having a rating of at least A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s Investors Service, (c) certificates of deposit issued by any bank with assets of at least $500,000,000 maturing no more than one year
from the date of investment therein, (d) money market accounts and (e) other Investments described in Borrower’s investment policy (as amended or otherwise modified from time to time as approved by Kura Oncology’s board of
directors and the Agent); 
 (iii) repurchases of stock from former or current employees, directors, or consultants of
Borrower under the terms of applicable repurchase agreements at the original issuance price of such securities in an aggregate amount not to exceed Five Hundred Thousand Dollars ($500,000) in any fiscal year, provided that no Event of Default has
occurred, is continuing or would exist immediately after giving effect to any such repurchase; 
 (iv) Investments accepted
in connection with Permitted Transfers; 
 (v) Investments (including debt obligations) (a) received in connection with
the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent or doubtful obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business and (b) consisting
of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business; 

(vi) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and
suppliers who are not Affiliates, in the ordinary course of business, provided that this subparagraph (vi) shall not apply to Investments of Borrower in any Subsidiary; 

(vii) Investments consisting of loans not involving the net transfer on a substantially contemporaneous basis of cash proceeds
to employees, officers or directors relating to the purchase of capital stock of Borrower pursuant to employee stock purchase plans or other similar agreements approved by Kura Oncology’s board of directors, not to exceed, in combination with
any Investments made pursuant to clause (viii) of this definition, Five Hundred Thousand Dollars ($500,000) in the aggregate in any fiscal year; 











 (viii) Investments consisting of travel advances in the ordinary course of
business, not to exceed, in combination with any Investments made pursuant to clause (vii) of this definition, Five Hundred Thousand Dollars ($500,000) in the aggregate in any fiscal year; 

(ix) Investments in newly-formed Subsidiaries, provided that each such Subsidiary enters into a Joinder Agreement promptly
after its formation by Borrower and execute such other documents as shall be reasonably requested by Agent; 
 (x)
Investments in Foreign Subsidiaries not to exceed $500,000 during any fiscal year or as approved in advance in writing by Agent; 

(xi) Permitted Acquisitions; 

(xii) Borrower’s entry into (including payments of premiums in connection therewith), and the performance of obligations
under, and the receipt of Common Stock upon termination, settlement or unwind of, any Permitted Bond Hedge Transactions and Permitted Warrant Transactions in accordance with their terms; 

(xiii) joint ventures or strategic alliances in the ordinary course of Borrower’s business, provided that any cash
Investments by Borrower do not exceed Five Hundred Thousand Dollars ($500,000) in the aggregate in any fiscal year; 
 (xiv)
Hedging Agreements permitted under the definition of Permitted Indebtedness; 
 (xv) Permitted Licenses, to the extent
constituting Investments; and 
 (xvi) additional Investments that do not exceed One Million Dollars ($1,000,000) in the
aggregate. 
 “Permitted License” means licenses and similar arrangements for the use of Intellectual Property (including
Corporate Collaborations not constituting Acquisitions) satisfying each of the following conditions: (a) [reserved], (b) such license could not result in a legal transfer of title of the licensed property, (c) such license is entered into
with non-Affiliate third parties and constitutes an arms-length transaction on commercially reasonably terms, and (d) such license is (w) non-exclusive,
(x) exclusive as to territory but only as to discrete geographical areas outside of the United States of America in the ordinary course of business, (y) exclusive solely with respect to Non-Core
Intellectual Property or (z) exclusive as to any territory including the United States solely with respect to any Corporate Collaborations; provided that, solely with respect to this clause (d)(z), at all times after the
consummation of and prior to the termination of any such transaction the Borrower is in compliance with Section 7.19(a)(ii). 

“Permitted Liens” means: 

(i) Liens in favor of Agent or the Lenders; 

(ii) Liens existing on the Closing Date which are disclosed in Schedule 1C to the Disclosure Letter; 

(iii) Liens for Taxes, fees, assessments or other governmental charges or levies, either not yet due or being contested in good
faith by appropriate proceedings diligently conducted; provided, that Borrower maintains adequate reserves therefor on Borrower’s Books in accordance with GAAP (to the extent required thereby); 











 (iv) Liens securing claims or demands of materialmen, artisans, mechanics,
carriers, warehousemen, landlords and other like Persons arising in the ordinary course of Borrower’s business and imposed without action of such parties; provided, that (A) the payment thereof is not yet required and (B) the
aggregate amount of the obligations secured by such liens does not at any time exceed Five Hundred Thousand Dollars ($500,000); 

(v) Liens arising from judgments, decrees or attachments in circumstances which do not constitute an Event of Default
hereunder; 
 (vi) the following deposits, to the extent made in the ordinary course of business: deposits to secure the
performance obligations (including by way of deposits to secure letters of credit issued to secure the same) under agreements with contract research organizations (CROs) or other similar commercial contracts, commercial supply and/or manufacturing
agreements, deposits under worker’s compensation, unemployment insurance, social security and other similar laws, or to secure the performance of bids, tenders or contracts (other than for the repayment of borrowed money) or to secure
indemnity, performance or other similar bonds for the performance of bids, tenders or contracts (other than for the repayment of borrowed money) or to secure statutory obligations (other than Liens arising under ERISA or environmental Liens) or
surety or appeal bonds, or to secure indemnity, performance or other similar bonds; 
 (vii) Liens on Equipment or software
or other intellectual property constituting purchase money Liens and Liens in connection with capital leases securing Indebtedness permitted in clause (iii) of “Permitted Indebtedness”; 

(viii) Liens incurred in connection with Subordinated Indebtedness; 

(ix) leasehold interests in leases or subleases (whether as lessor or lessee thereunder) and licenses or sublicenses granted in
the ordinary course of business and not interfering in any material respect with the business of the licensor; 
 (x) Liens
in favor of customs and revenue authorities arising as a matter of law to secure payment of custom duties that are promptly paid on or before the date they become due; 

(xi) Liens on insurance proceeds securing the payment of financed insurance premiums that are promptly paid on or before the
date they become due (provided that such Liens extend only to such insurance proceeds and not to any other property or assets); 

(xii) statutory and common law rights of set-off and other similar rights as to
deposits of cash and securities in favor of banks, other depository institutions and brokerage firms; 
 (xiii) easements,
servitudes, zoning restrictions, rights-of-way and similar encumbrances on real property imposed by law or arising in the ordinary course of business so long as they do
not materially impair the value or marketability of the related property; 
 (xiv) Permitted Licenses; 

(xv) Liens solely on the royalty interests purchased pursuant to a Permitted Royalty Transaction and proceeds thereof and
Intellectual Property being financed by such facility; 
 (xvi) (A) Liens on Cash or government securities securing
obligations permitted under clause (vii) of the definition of Permitted Indebtedness and (B) security deposits in connection with 











 
real property leases, the combination of (A) and (B) in an aggregate amount not to One Million Dollars ($1,000,000) at any time; 

(xvii) Liens on Cash securing obligations under corporate credit cards permitted under clause (iv) of the definition of
Permitted Indebtedness; 
 (xviii) Liens in favor of financial institutions arising in connection with Borrower’s
deposit and/or securities accounts held at such institutions, provided that (i) such accounts are permitted by this Agreement and (ii) Agent has a first priority perfected security interest in the amounts held in such deposit and/or
securities accounts other than Excluded Accounts; 
 (xix) Liens incurred in connection with sales, transfers, licenses,
sublicenses, leases, subleases or other dispositions of assets in the ordinary course of business and permitted by Section 7.8 and, in connection therewith, customary rights and restrictions contained in agreements relating to such transactions
pending the completion thereof or during the term thereof, and any option or other agreement to sell, transfer, license, sublicense, lease, sublease or dispose of an asset permitted by Section 7.8; 

(xx) Liens in the nature of deposits, or liens on deposit accounts, to secure (i) the performance of tenders, bids, trade
and commercial contracts, licenses and leases, statutory obligations, surety bonds, performance bonds, bank guaranties and other obligations of a like nature incurred in the ordinary course of business (including earnest money deposits in respect of
any asset acquisition) or (ii) indemnification obligations relating to any disposition; provided that, in each case, such Liens do not secure Indebtedness for borrowed money and are incurred in the ordinary course of business; 

(xxi) good faith deposits required in connection with any Permitted Acquisition in the ordinary course of business; 

(xxii) to the extent constituting Liens, escrow arrangements securing indemnification obligations associated with any Permitted
Acquisition; 
 (xxiii) Liens securing Indebtedness described in clause (xix) of the definition of Permitted
Indebtedness; provided that (i) such Lien is not created in contemplation of or in connection with such Permitted Acquisition pursuant to which such Indebtedness was assumed, (ii) such Lien shall not apply to any other property or assets
of Borrower or any Subsidiary other than the assets subject to such Liens immediately prior to the consummation of such Permitted Acquisition, (iii) such Lien shall be limited to specific assets and not all assets or substantially all assets of
Borrower or any Subsidiary and (iv) such Lien shall secure only those obligations that it secured immediately prior to the consummation of such Permitted Acquisition; 

(xxiv) additional Liens not otherwise permitted hereunder in an aggregate amount not to exceed One Million Dollars
($1,000,000); and 
 (xxv) Liens incurred in connection with the extension, renewal or refinancing of the Indebtedness
secured by Liens of the type described in clauses (i) through (xxiv) above; provided, that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the
Indebtedness being extended, renewed or refinanced (as may have been reduced by any payment thereon) does not increase. 











 “Permitted Royalty Transaction” means any synthetic royalty participation (and not
royalty purchases or buyouts) in the ordinary course of business and on terms, in each case, reasonably satisfactory to Agent, as long as (i) such transaction does not interfere with the security interest granted to Agent pursuant to this
Agreement, (ii) such transaction does not result in a transfer of title to any Intellectual Property, (iii) such transaction does not result in a transfer of any Rights to Payment of any Intellectual Property, (iv) the beneficiary is
Borrower or a Subsidiary that has executed and delivered to Agent a Joinder Agreement pursuant to Section 7.13 and (v) all fees and payments with respect to such transaction (including, without limitation, with respect to the underlying
Intellectual Property and Rights to Payment) are payable to Borrower or such Subsidiary, as applicable, and made to an Account subject to an Account Control Agreement. 

“Permitted Transfers” means: 

(i) sales, transfers or other dispositions of Inventory in the ordinary course of business, 

(ii) Permitted Licenses; 

(iii) Permitted Royalty Transactions; 

(iv) dispositions of worn-out, obsolete or surplus Equipment at fair market value in
the ordinary course of business and of Intellectual Property not material to Borrower’s business in the ordinary course of business; 

(v) use or transfer of Cash in the ordinary course of business in a manner not prohibited by the terms of this Agreement; 

(vi) Transfers by and among Borrower and any Subsidiary that has executed a Joinder Agreement; 

(vii) Transfers constituting the making of Permitted Investments or the granting of Permitted Liens; 

(viii) sale or issuance of Equity Interests of Kura Oncology in the ordinary course of business not constituting a Change of
Control and otherwise in a manner not prohibited by the terms of this Agreement; 
 (ix) Transfers in connection with the
termination or unwind of any Permitted Bond Hedge Transaction; 
 (x) Retirements of abandoned or expired Intellectual
Property not material to Borrower’s business; and 
 (xi) other Transfers of assets having a fair market value of not
more than Five Hundred Thousand Dollars ($500,000) in the aggregate in any fiscal year. 
 “Permitted Warrant Transaction” means
any call option, warrant or right to purchase (or substantively equivalent derivative transaction) relating to Common Stock (or other securities or property following a merger event or other change of the Common Stock) and/or cash (in an amount
determined by reference to the price of such Common Stock) sold by Borrower substantially concurrently with any purchase by Borrower of a related Permitted Bond Hedge Transaction and as may be amended in












 
accordance with its terms; provided that (x) that the terms, conditions and covenants of each such call option transaction are customary for agreements of such type, as determined in good
faith by the Borrower and (y) such call option transaction would be classified as an equity instrument in accordance with GAAP. 

“Person” means any individual, sole proprietorship, partnership, joint venture, trust, unincorporated organization, association,
corporation, limited liability company, institution, other entity or government. 
 “Positive Clinical Data” means, with respect
to a clinical trial, Borrower shall have issued a press release announcing that (i) such clinical trial has achieved its protocol-specified primary efficacy endpoint with statistical significance; and (ii) the investigational product under
evaluation was well tolerated, in each case subject to reasonable verification by Agent (including any supporting documentation reasonably requested by Agent). 

“Qualified Cash” means Cash held by Borrower subject to an Account Control Agreement. 

“Qualified Equity Interests” means any Equity Interests that are not Disqualified Equity Interests. 

“Receivables” means (i) all of Borrower’s Accounts, Instruments, Documents, Chattel Paper, Supporting Obligations, letters
of credit, proceeds of any letter of credit, and Letter of Credit Rights, and (ii) all customer lists, software, and business records related thereto. 

“Redemption Conditions” means, with respect to any payment of cash in respect of the principal amount of any Permitted Convertible
Debt, satisfaction of each of the following events: (a) at the time of such redemption, no Default or Event of Default shall exist or result therefrom, and (b) both immediately before and at all times after such redemption, Borrower’s
Qualified Cash shall be not less than 150% of the outstanding Secured Obligations. 
 “Required Lenders” means at any time, the
holders of more than 50% of the aggregate unpaid principal amount of the Term Loan Advances then outstanding. 
 “Sanctioned
Country” means, at any time, a country or territory which is the subject or target of any Sanctions. 
 “Sanctioned Person”
means, at any time, (a) any Person listed in any Sanctions-related list of designated Persons maintained by the Office of Foreign Assets Control of the U.S. Department of the Treasury or the U.S. Department of State, or by the United Nations
Security Council, the European Union or any EU member state, (b) any Person operating, organized or resident in a Sanctioned Country or (c) any Person controlled by any such Person. 

“Sanctions” means economic or financial sanctions or trade embargoes imposed, administered or enforced from time to time by
(a) the U.S. government, including those administered by the Office of Foreign Assets Control of the U.S. Department of the Treasury or the U.S. Department of State, or (b) the United Nations Security Council, the European Union or Her
Majesty’s Treasury of the United Kingdom. 
 “SBA Funding Date” means each date on which a Lender which is an SBIC funds any
portion of the Term Loan. 











 “Secured Obligations” means Borrower’s obligations under this Agreement and
any Loan Document (other than the Warrant), including any obligation to pay any amount now owing or later arising. 
 “Subordinated
Indebtedness” means Indebtedness subordinated to the Secured Obligations in amounts and on terms and conditions satisfactory to Agent in its reasonable discretion and subject to a subordination agreement in form and substance satisfactory to
Agent in its sole discretion. 
 “Subsequent Financing” means the closing of any bona fide Borrower financing event with the
primary purpose of raising capital which becomes effective after the Closing Date in which Borrower offers to sell its Equity Interests. 

“Subsidiary” means an entity, whether a corporation, partnership, limited liability company, joint venture or otherwise, in which
Borrower owns or controls, either directly or indirectly, 50% or more of the outstanding voting securities, including each entity listed on Schedule 1 to the Disclosure Letter. 

“Taxes” means all present or future taxes, levies, imposts, duties, deductions, withholdings (including backup withholding),
assessments, fees or other charges imposed by any governmental authority, including any interest, additions to tax or penalties applicable thereto. 

“Term Commitment” means as to any Lender, the obligation of such Lender, if any, to make a Term Loan Advance to Borrower in a
principal amount not to exceed the amount set forth under the heading “Term Commitment” opposite such Lender’s name on Schedule 1.1. 

“Term Loan Advance” means each Tranche 1 Advance, Tranche 2 Advance, Tranche 3 Advance, Tranche 4 Advance and any other Term Loan
funds advanced under this Agreement. 
 “Term Loan Interest Rate” means for any day a per annum rate of interest equal to the
greater of either (i) the prime rate as reported in The Wall Street Journal minus 6.25%, plus 8.65%, and (ii) 8.65%. 
 “Term Loan
Maturity Date” means November 1, 2027; provided that if such day is not a Business Day, the Term Loan Maturity Date shall be the immediately preceding Business Day. 

“Tipifarnib” means Borrower’s clinical-stage farnesyl transferase inhibitor product candidate tipifarnib. 

“Trademark License” means any written agreement granting any right to use any Trademark or Trademark registration, now owned or
hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Trademarks” means all
trademarks (registered, common law or otherwise) and any applications in connection therewith, including registrations, recordings and applications in the United States Patent and Trademark Office or in any similar office or agency of the United
States of America, any State thereof or any other country or any political subdivision thereof. 
 “Tranche 1 Expiration Date”
means September 15, 2023. 
 “Tranche 2 Expiration Date” means March 15, 2024. 

“Tranche 2 Facility Charge” means one half of one percent (0.50%) of the Tranche 2 Commitment, which is payable to the Lenders in
accordance with Section 4.2(e). 











 “Tranche 2 Milestone” means satisfaction of each of the following events, subject
to reasonable verification by Agent: (a) no Default or Event of Default shall have occurred; (b) Borrower has announced Positive Clinical Data from the phase 1b study evaluating Ziftomenib, clinicaltrials.gov identifier #NCT04067336, for
the treatment of relapsed/refractory acute myeloid leukemia and has dosed the first patient in a registration-enabling trial, in each case subject to reasonable verification by Agent (including any supporting documentation requested by Agent); and
(c) either (x) Borrower has drawn the Tranche 1 Advance in full or (y) the Tranche 1 Expiration Date has passed. 
 “Tranche
2 Milestone Date” means the date on which Borrower achieves the Tranche 2 Milestone. 
 “Tranche 3 Expiration Date” means
December 15, 2024. 
 “Tranche 3 Facility Charge” means one half of one percent (0.50%) of the Tranche 3 Commitment, which is
payable to the Lenders in accordance with Section 4.2(f). 
 “Tranche 3 Milestone” means satisfaction of each of the
following events, subject to reasonable verification by Agent: (a) no Default or Event of Default shall have occurred; (b) satisfaction of the Interest-Only Milestone 1; (c) the registration-enabling trial evaluating Ziftomenib for the
treatment of acute myeloid leukemia remains ongoing; (d) Borrower has submitted an IND with respect to KO-2806 and the FDA has allowed Borrower to proceed with clinical studies under such IND; (e) a
phase 2 study evaluating the combination of a proprietary farnesyl transferase inhibitor and another targeted therapy has been initiated, in each case subject to reasonable verification by Agent (including any supporting documentation requested by
Agent); and (f) either (x) Borrower has drawn the Tranche 1 Advance and Tranche 2 Advance in full or (y) the Tranche 2 Expiration Date has passed. 

“Tranche 3 Milestone Date” means the date on which Borrower achieves the Tranche 3 Milestone. 

“Tranche 4 Facility Charge” means one half of one percent (0.50%) of the Tranche 4 Commitment, which is payable to the Lenders in
accordance with Section 4.2(g). 
 “UCC” means the Uniform Commercial Code as the same is, from time to time, in effect in
the State of California; provided, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection or priority of, or remedies with respect to, Agent’s Lien on any Collateral is governed by the Uniform
Commercial Code as the same is, from time to time, in effect in a jurisdiction other than the State of California, then the term “UCC” shall mean the Uniform Commercial Code as in effect, from time to time, in such other jurisdiction
solely for purposes of the provisions thereof relating to such attachment, perfection, priority or remedies and for purposes of definitions related to such provisions. 

“U.S. Person” means any Person that is a “United States person” as defined in Section 7701(a)(30) of the Code. 

“Warrant” means any warrant entered into in connection with the Loan, as may be amended, restated or modified from time to time.

 “Ziftomenib” means Borrower’s clinical-stage product candidate ziftomenib, the international nonproprietary name for KO-539. 
 1.2 The following terms are defined in the Sections or subsections referenced
opposite such terms: 












							
	 	  	 Defined Term
	  	 Section
	  	 
		  	 Agent
	  	 Preamble
	  	
		  	 Assignee
	  	 11.14
	  	
		  	 Borrower
	  	 Preamble
	  	
		  	 Claims
	  	 11.11
	  	
		  	 Collateral
	  	 3.1
	  	
		  	 Confidential Information
	  	 11.13
	  	
		  	 End of Term Charge
	  	 2.6
	  	
		  	 Event of Default
	  	 9
	  	
		  	 Financial Statements
	  	 7.1
	  	
		  	 Indemnified Person
	  	 6.3
	  	
		  	 Lenders
	  	 Preamble
	  	
		  	 Liabilities
	  	 6.3
	  	
		  	 Maximum Rate
	  	 2.3
	  	
		  	 Open Source License
	  	 5.10
	  	
		  	 Participant Register
	  	 11.8
	  	
		  	 Prepayment Charge
	  	 2.5
	  	
		  	 Publicity Materials
	  	 11.19
	  	
		  	 Register
	  	 11.7
	  	
		  	 Rights to Payment
	  	 3.1
	  	
		  	 SBA
	  	 7.16
	  	
		  	 SBIC
	  	 7.16
	  	
		  	 SBIC Act
	  	 7.16
	  	
		  	 Tranche 1 Maximum Amount
	  	 2.2(a)(ii)
	  	
		  	 Tranche 1A Advance
	  	 2.2(a)
	  	
		  	 Tranche 1B Advance
	  	 2.2(a)
	  	
		  	 Tranche 2 Advance
	  	 2.2(a)
	  	
		  	 Tranche 3 Advance
	  	 2.2(a)
	  	
		  	 Tranche 4 Advance
	  	 2.2(a)
	  	

 1.3 Unless otherwise specified, all references in this Agreement or any Annex or Schedule
hereto to a “Section,” “subsection,” “Exhibit,” “Annex,” or “Schedule” shall refer to the corresponding Section, subsection, Exhibit, Annex, or Schedule in or to this Agreement or the Disclosure
Letter, as applicable. Unless otherwise specifically provided herein, any accounting term used in this Agreement or the other Loan Documents shall have the meaning customarily given such term in accordance with GAAP, and all financial computations
hereunder shall be computed in accordance with GAAP, consistently applied; provided that, no effect shall be given to Accounting Standards Codification 842, Leases (or any other Accounting Standards Codification having similar result or effect) (and
related interpretations) to the extent any lease (or similar arrangement) would be required to be treated as a capital lease thereunder where such lease (or arrangement) would have been treated as an operating lease under GAAP as in effect
immediately prior to the effectiveness of such Accounting Standards Codification. Unless otherwise defined herein or in the other Loan Documents, terms that are used herein or in the other Loan Documents and defined in the UCC shall have the
meanings given to them in the UCC. For all purposes under the Loan Documents, in connection with any division or plan of division under Delaware law (or any comparable 











 
event under a different jurisdiction’s laws): (a) if any asset, right, obligation or liability of any Person becomes the asset, right, obligation or liability of a different Person, then it
shall be deemed to have been transferred from the original Person to the subsequent Person and (b) if any new Person comes into existence, such new Person shall be deemed to have been organized on the first date of its existence by the holders
of its Equity Interests at such time. 
 1.4 Notwithstanding anything to the contrary in this Agreement or any other Loan
Document, all terms of an accounting or financial nature used herein shall be construed, and all computations of amounts and ratios referred to herein shall be made without giving effect to any treatment of Indebtedness in respect of convertible
debt instruments under Accounting Standards Codification 470-20 (or any other Accounting Standards Codification or Financial Accounting Standard having a similar result or effect) to value any such
Indebtedness in a reduced or bifurcated manner as described therein, and such Indebtedness shall at all times be valued at the full stated principal amount thereof. For the avoidance of doubt, and without limitation of the foregoing, Permitted
Convertible Debt shall at all times be valued at the full stated principal amount thereof and shall not include any reduction or appreciation in value of the shares deliverable upon conversion thereof. 

SECTION 2. THE LOAN 

2.1 [Reserved] 

2.2 Term Loan. 

(a) Advances: 

(i) Subject to the terms and conditions of this Agreement, the Lenders will severally (and not jointly) make in an amount not
to exceed its respective Term Commitment, and Borrower agrees to draw, a Term Loan Advance of at least Ten Million Dollars ($10,000,000) but not to exceed Twenty-Five Million Dollars ($25,000,000) (the “Tranche 1 Maximum Amount”) on the
Closing Date (the “Tranche 1A Advance”). 
 (ii) If the drawn amount of the Tranche 1A Advance is less than the
Tranche 1 Maximum Amount, subject to the terms and conditions of this Agreement, beginning on the Closing Date and continuing through the Tranche 1 Expiration Date, Borrower may request and the Lenders shall severally (and not jointly) make an
additional Term Loan Advance in a principal amount equal to the difference between the amount of the Tranche 1A Advance drawn on the Closing Date and the Tranche 1 Maximum Amount, in minimum increments of Five Million Dollars ($5,000,000) (the
“Tranche 1B Advance”, and together with the Tranche 1A Advance, each, a “Tranche 1 Advance”). 
 (iii)
Subject to the terms and conditions of this Agreement, beginning on the Tranche 2 Milestone Date and continuing through the Tranche 2 Expiration Date, Borrower may request and the Lenders shall severally (and not jointly) make an additional Term
Loan Advance in a principal amount of Thirty-Five Million Dollars ($35,000,000), in minimum increments of Five Million Dollars ($5,000,000) (the “Tranche 2 Advance”). 

(iv) Subject to the terms and conditions of this Agreement, beginning on the Tranche 3 Milestone Date and continuing through
the Tranche 3 Expiration Date, Borrower may request and the Lenders shall severally (and not jointly) make an additional Term Loan Advance in a principal amount of Forty Million Dollars ($40,000,000), in minimum increments of Five Million Dollars
($5,000,000) (the “Tranche 3 Advance”). 











 (v) Subject to the terms and conditions of this Agreement and conditioned on
approval by the Lenders’ investment committee in its sole and unfettered discretion, on or before the Tranche 3 Expiration Date, Borrower may request an additional Term Loan Advance in a principal amount of Twenty-Five Million Dollars
($25,000,000), in minimum increments of Five Million Dollars ($5,000,000) (the “Tranche 4 Advance”). The aggregate outstanding Term Loan Advances may be up to the Maximum Term Loan Amount. 

(b) Advance Request. To obtain a Term Loan Advance, Borrower shall complete, sign and deliver an Advance Request (at least one
(1) Business Day before the Closing Date and at least five (5) Business Days before each Advance Date other than the Closing Date) to Agent. The Lenders shall fund the Term Loan Advance in the manner requested by the Advance Request
provided that each of the conditions precedent set forth in Section 4 and applicable to such Term Loan Advance is satisfied as of the requested Advance Date. 

(c) Interest. The principal balance shall bear interest thereon from such Advance Date at the Term Loan Interest Rate based on
a year consisting of 360 days, with interest computed daily based on the actual number of days elapsed. The Term Loan Interest Rate will float and change on the day the prime rate changes from time to time. 

(d) Payment. Borrower will pay accrued and unpaid interest on each outstanding Term Loan Advance on the first Business Day of
each month, beginning the month after the applicable Advance Date for such Term Loan Advance. Commencing with the Amortization Date, and continuing on the first Business Day of each month until the Term Loan Maturity Date, Borrower shall repay the
aggregate principal balance of the Term Loan Advances that are outstanding on the day immediately preceding the Amortization Date, in equal monthly installments of principal and interest (mortgage style) beginning on the Amortization Date and
continuing on the first Business Day of each month thereafter until the Secured Obligations (other than inchoate indemnity or reimbursement obligations and any other obligations which, by their terms, are to survive the termination of this
Agreement) are repaid. The entire Term Loan principal balance and all accrued but unpaid interest hereunder, shall be due and payable on the Term Loan Maturity Date. Borrower shall make all payments under this Agreement without setoff, recoupment or
deduction and regardless of any counterclaim or defense. If a payment hereunder becomes due and payable on a day that is not a Business Day, the due date thereof shall be the immediately preceding Business Day. The Lenders will initiate debit
entries to Borrower’s account as authorized on the ACH Authorization (i) on each payment date of all periodic obligations payable to the Lenders under each Term Loan Advance and (ii) reasonable and documented out-of-pocket legal fees and costs incurred by Agent or the Lenders in connection with Section 11.12 of this Agreement; provided that, with respect to clause
(i) above, in the event that the Lenders or Agent inform Borrower in writing that the Lenders will not initiate a debit entry to Borrower’s account for a certain amount of the periodic obligations due on a specific payment date, Borrower
shall pay to the Lenders (or to Agent, for the ratable benefit of the Lenders) such amount of periodic obligations in full in immediately available funds on such payment date; provided, further, that, with respect to clause (i) above, if the
Lenders or Agent inform Borrower in writing that the Lenders will not initiate a debit entry as described above later than the date that is three (3) Business Days prior to such payment date, Borrower shall pay to the Lenders (or to Agent, for
the ratable benefit of the Lenders) such amount of periodic obligations in full in immediately available funds on the date that is three (3) Business Days after the date on which the Lenders or Agent notify Borrower of such; provided, further,
that, with respect to clause (ii) above, in the event that the Lenders or Agent informs Borrower that the Lenders will not initiate a debit entry to Borrower’s account for certain amount of such out-of-pocket legal fees and costs incurred by Agent or the Lenders, Borrower shall pay to the Lenders such amount in full 











 
in immediately available funds within five (5) Business Days of Agent or the Lenders furnishing to Borrower an invoice for such out-of-pocket legal fees and costs incurred by Agent or the Lenders. 
 2.3 Maximum
Interest. Notwithstanding any provision in this Agreement or any other Loan Document, it is the parties’ intent not to contract for, charge or receive interest at a rate that is greater than the maximum rate permissible by law that a court of
competent jurisdiction shall deem applicable hereto (which under the laws of the State of California shall be deemed to be the laws relating to permissible rates of interest on commercial loans) (the “Maximum Rate”). If a court of
competent jurisdiction shall finally determine that Borrower has actually paid to the Lenders an amount of interest in excess of the amount that would have been payable if all of the Secured Obligations had at all times borne interest at the Maximum
Rate, then such excess interest actually paid by Borrower shall be applied as follows: first, to the payment of the Secured Obligations consisting of the outstanding principal; second, after all principal is repaid, to the payment of the
Lenders’ accrued interest, costs, reasonable and documented expenses, professional fees and any other Secured Obligations; and third, after all Secured Obligations are repaid, the excess (if any) shall be refunded to Borrower. 

2.4 Default Interest. In the event any payment is not paid on the scheduled payment date (other than a failure to pay due
solely to an administrative or operational error of Agent or the Lenders or Borrower’s bank if Borrower had the funds to make the payment when due and makes the payment within three (3) Business Days following Borrower’s knowledge of
such failure to pay), an amount equal to five percent (5%) of the past due amount shall be payable on demand. In addition, upon the occurrence and during the continuation of an Event of Default hereunder, all outstanding Secured Obligations,
including principal, interest, compounded interest, and reasonable and documented out-of-pocket professional fees, shall bear interest at a rate per annum equal to the
rate set forth in Section 2.2(c) plus four percent (4%) per annum. In the event any interest is not paid when due hereunder, delinquent interest shall be added to principal and shall bear interest on interest, compounded at the rate set forth
in Section 2.2(c) or Section 2.4, as applicable. 
 2.5 Prepayment. At its option, Borrower may prepay all or a
portion of the outstanding Advances by paying the entire principal balance (or such portion thereof), all accrued and unpaid interest thereon, together with a prepayment charge equal to the following percentage of the Advance amount being prepaid:
with respect to each Advance, if such Advance amounts are prepaid in any of the first thirty-six (36) months following the Closing Date, 1.50% and thereafter, 0% (the “Prepayment Charge”). If at
any time Borrower elects to make a prepayment, and at such time, there are outstanding Advances under multiple Tranches, the Prepayment Charge shall be determined by applying the amount of such prepayment in the following order: first, to the
outstanding principal amount (and accrued but unpaid interest thereon) of Advances outstanding under the Tranche with the latest initial funding date; second, to the outstanding principal amount (and accrued but unpaid interest thereon) of Advances
outstanding under the Tranche with the next latest initial funding date and so on until the entire principal balance of all Advances made hereunder (and all accrued but unpaid interest thereon) is paid in full. Borrower agrees that the
Prepayment Charge is a reasonable calculation of the Lenders’ lost profits in view of the difficulties and impracticality of determining actual damages resulting from an early repayment of the Advances. Borrower shall prepay the outstanding
amount of all principal and accrued interest through the prepayment date and the Prepayment Charge upon the occurrence of a Change in Control or any other prepayment hereunder. Notwithstanding the foregoing, Agent and the Lenders agree to waive the
Prepayment Charge if Agent and the Lenders (in their sole and absolute discretion) agree in writing to refinance the Advances prior to the Term Loan Maturity Date. Any amounts paid under this Section shall be applied by Agent to the then unpaid
amount of any Secured Obligations (including principal and interest) in such order and priority as Agent may choose in its sole discretion. In connection with any 











 
prepayment of all outstanding Secured Obligations in accordance with the terms herein, Borrower may request to terminate this Agreement and the Term Commitments upon such repayment of all
outstanding Secured Obligations by written notice to Agent. For the avoidance of doubt, if a payment hereunder becomes due and payable on a day that is not a Business Day, the due date thereof shall be the immediately preceding Business Day. 

2.6 End of Term Charge. On the earliest to occur of (i) the Term Loan Maturity Date, (ii) the date that Borrower
prepays the outstanding Secured Obligations (other than any inchoate indemnity or reimbursement obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) in full, or (iii) the date that the
Secured Obligations become due and payable, Borrower shall pay the Lenders a charge in an amount equal to 6.05% of the greater of (a) the Tranche 1 Maximum Amount or (b) the aggregate principal amount of Advances actually made pursuant to
this Agreement (the “End of Term Charge”). Notwithstanding the required payment date of such End of Term Charge, it shall be deemed earned by the Lenders as of the Closing Date. For the avoidance of doubt, if a payment hereunder becomes
due and payable on a day that is not a Business Day, the due date thereof shall be the immediately preceding Business Day. 

2.7 Pro Rata Treatment. Each payment (including prepayment) on account of any fee and any reduction of the Term Loan Advances
shall be made pro rata according to the Term Commitments of the relevant Lender. 
 2.8 Taxes; Increased Costs. Borrower, the
Agent and the Lenders each hereby agree to the terms and conditions set forth on Addendum 1 attached hereto. 
 2.9 Treatment
of Prepayment Charge and End of Term Charge. Except as otherwise required by applicable Tax law, Borrower agrees that any Prepayment Charge and any End of Term Charge payable shall be presumed to be the liquidated damages sustained by each Lender as
the result of the early termination, and Borrower agrees that it is reasonable under the circumstances currently existing and existing as of the Closing Date. The Prepayment Charge and the End of Term Charge shall also be payable in the event the
Secured Obligations (and/or this Agreement) are satisfied or released by foreclosure (whether by power of judicial proceeding), deed in lieu of foreclosure, or by any other means. Borrower expressly waives (to the fullest extent it may lawfully do
so) the provisions of any present or future statute or law that prohibits or may prohibit the collection of the foregoing Prepayment Charge and End of Term Charge in connection with any such acceleration. Borrower agrees (to the fullest extent that
each may lawfully do so): (a) each of the Prepayment Charge and the End of Term Charge is reasonable and is the product of an arm’s length transaction between sophisticated business people, ably represented by counsel; (b) each of the
Prepayment Charge and the End of Term Charge shall be payable notwithstanding the then prevailing market rates at the time payment is made; (c) there has been a course of conduct between the Lenders and Borrower giving specific consideration in
this transaction for such agreement to pay the Prepayment Charge and the End of Term Charge as a charge (and not interest) in the event of prepayment or acceleration; and (d) Borrower shall be estopped from claiming differently than as agreed
to in this paragraph. Borrower expressly acknowledges that its agreement to pay each of the Prepayment Charge and the End of Term Charge to the Lenders as herein described was on the Closing Date and continues to be a material inducement to the
Lenders to provide the Term Loan Advances. 
 SECTION 3. SECURITY INTEREST 











 3.1 As security for the prompt and complete payment when due (whether on the
payment dates or otherwise) of all the Secured Obligations, Borrower grants to Agent a security interest in all of Borrower’s right, title, and interest in, to and under all of Borrower’s personal property and other assets including
without limitation the following (except as set forth herein) whether now existing or hereafter acquired (collectively, the “Collateral”): (a) Receivables; (b) Equipment; (c) Fixtures; (d) General Intangibles (other than
Intellectual Property); (e) Inventory; (f) Investment Property; (g) Deposit Accounts; (h) Cash; (i) Goods; (j) Chattel Paper; (k) Documents; (l) Instruments;
(m) Letter-of-Credit Rights; (n) Commercial Tort Claims and all other tangible and intangible personal property of Borrower whether now or hereafter owned or
existing, leased, consigned by or to, or acquired by, Borrower and wherever located, and any of Borrower’s property in the possession or under the control of Agent; and, to the extent not otherwise included, all Proceeds of each of the
foregoing and all accessions to, substitutions and replacements for, and rents, profits and products of each of the foregoing; provided, however, that the Collateral shall include all Accounts and General Intangibles that
consist of rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the Intellectual Property (the “Rights to Payment”). Notwithstanding the foregoing, if a judicial authority
(including a U.S. Bankruptcy Court) holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of the date of
this Agreement, include the Intellectual Property to the extent necessary to permit perfection of Agent’s security interest in the Rights to Payment. 

3.2 Notwithstanding the broad grant of the security interest set forth in Section 3.1, above, the Collateral shall not
include (a) any property, right or asset held by Borrower to the extent that a grant of a security interest therein is prohibited by any Requirement of Law of a Governmental Authority or constitutes a breach or default under or results in the
termination of or requires any consent not obtained under, any contract, license, agreement, instrument or other document evidencing or giving rise to such property, right or asset, (b) nonassignable licenses or contracts, or licenses or
contracts which by their terms require consent to assignment from the licensor thereof or another party or provide that an assignment or grant of a security interest therein would violate or invalidate such license or contract or create a right of
termination in favor of any other party thereto (other than to the extent that any such term would be rendered ineffective pursuant to applicable law, including, without limitation, Sections 9406, 9407 and 9408 of the UCC); (c) any cash
collateral deposit subject to a Permitted Lien hereunder, if the grant of a security interest with respect to such property pursuant to this Agreement would be prohibited by the agreement creating such Permitted Lien or would otherwise constitute a
default thereunder or create a right of termination a party thereto (other than Borrower), provided that upon the termination and release of such cash collateral, such property shall automatically be included in the Collateral; (d) any Excluded
Account, (e) interests in joint ventures that constitute Permitted Investments pursuant to customary restrictions and conditions contained in agreements governing such joint ventures in the ordinary course of business, provided that Borrower
has exercised its good faith best efforts to not agree to such contractual limitations and (f) assets as to Agent and Borrower agree that the costs of obtaining or perfecting such security interest are excessive in relation to the benefit to
the Lenders of the security to be afforded thereby. 
 3.3 The security interest granted in Section 3.1 shall continue
until the Secured Obligations (other than any inchoate indemnity or reimbursement obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) have been paid in full and Agent has no further
commitment or obligation hereunder or under the other Loan Documents to make any further Advances, and shall thereupon terminate, and Lender shall, at Borrower’s expense, take all actions reasonably requested by Borrower to evidence such
termination. 











 SECTION 4. CONDITIONS PRECEDENT TO LOAN 

The obligations of the Lenders to make the Loan hereunder are subject to the satisfaction by Borrower of the following conditions: 

4.1 Initial Advance. On or prior to the Closing Date, Borrower shall have delivered to Agent the following: 

(a) executed copies of the Loan Documents (other than the Warrant, which shall be an original), Account Control Agreements, and
all other documents and instruments reasonably required by Agent to effectuate the transactions contemplated hereby or to create and perfect the Liens of Agent with respect to all Collateral, in all cases in form and substance reasonably acceptable
to Agent; 
 (b) a legal opinion of Borrower’s counsel in form and substance reasonably acceptable to Agent, 

(c) certified copy of resolutions of Borrower’s board of directors evidencing approval of (i) the Loan and other
transactions evidenced by the Loan Documents; and (ii) the Warrant and transactions evidenced thereby; 
 (d) certified
copies of the Certificate of Incorporation and the Bylaws, as amended through the Closing Date, of Borrower; 
 (e) a
certificate of good standing for Borrower from its state of incorporation and similar certificates from all other jurisdictions in which it does business and where the failure to be qualified would have a Material Adverse Effect; 

(f) payment of the Due Diligence Fee, Initial Facility Charge and reimbursement of Agent’s and the Lenders’ current
expenses reimbursable pursuant to this Agreement, which amounts may be deducted from the initial Advance; 
 (g) all
certificates of insurance and copies of each insurance policy required hereunder; and 
 (h) such other documents as Agent
may reasonably request. 
 4.2 All Advances. On each Advance Date: 

(a) Agent shall have received (i) an Advance Request for the relevant Advance as required by Section 2.2(b), each
duly executed by Borrower’s Chief Executive Officer or principal accounting officer, and (ii) any other documents Agent may reasonably request. 

(b) The representations and warranties set forth in this Agreement shall be true and correct in all material respects on and as
of the applicable Advance Date with the same effect as though made on and as of such date, except to the extent such representations and warranties expressly relate to an earlier date. 

(c) Borrower shall be in compliance with all the terms and provisions set forth herein and in each other Loan Document on its
part to be observed or performed, and at the time of and immediately after such Advance no Event of Default shall have occurred and be continuing. 











 (d) Each Advance Request shall be deemed to constitute a representation and
warranty by Borrower on the relevant Advance Date as to the matters specified in paragraphs (b) and (c) of this Section 4.2 and as to the matters set forth in the Advance Request. 

(e) With respect to any Tranche 2 Advance, Borrower shall have (x) achieved the Tranche 2 Milestone and (y) paid the
Tranche 2 Facility Charge (which may, at the election of Borrower, be netted from proceeds of the Tranche 2 Advance). 
 (f)
With respect to any Tranche 3 Advance, Borrower shall have (x) achieved the Tranche 3 Milestone and (y) paid the Tranche 3 Facility Charge (which may, at the election of Borrower, be netted from proceeds of the Tranche 3 Advance). 

(g) With respect to any Tranche 4 Advance, Borrower shall have (x) received approval to draw such Tranche 4 Advance from
the Lenders’ investment committee in its sole and unfettered discretion and (y) paid the Tranche 4 Facility Charge (which may, at the election of Borrower, be netted from proceeds of the Tranche 4 Advance). 

4.3 No Default. As of the Closing Date and each Advance Date, (i) no fact or condition exists that constitutes (or would,
with the passage of time, the giving of notice, or both constitute) an Event of Default and (ii) no event that has had or would reasonably be expected to have a Material Adverse Effect has occurred and is continuing. 

SECTION 5. REPRESENTATIONS AND WARRANTIES OF BORROWER 

Borrower represents and warrants that: 

5.1 Corporate Status. Borrower is a corporation duly organized, legally existing and in good standing under the laws its state
of incorporation, and is duly qualified as a foreign corporation in all jurisdictions in which the nature of its business or location of its properties require such qualifications and where the failure to be qualified could reasonably be expected to
have a Material Adverse Effect. Borrower’s present name, former names (if any), locations, place of formation, taxpayer identification number, organizational identification number and other information are correctly set forth in Schedule 5.1 to
the Disclosure Letter, as may be updated by Borrower in a written notice (including any Compliance Certificate) provided to Agent after the Closing Date. 

5.2 Collateral. Borrower owns or otherwise has the rights to use the Collateral and owns, or has rights to, the Intellectual
Property, free of all Liens, except for Permitted Liens. Borrower has the power and authority to grant to Agent a Lien in the Collateral as security for the Secured Obligations. 

5.3 Consents. Borrower’s execution, delivery and performance of this Agreement and all other Loan Documents, and
Borrower’s execution of the Warrant, (i) have been duly authorized by all necessary corporate action of Borrower, (ii) will not result in the creation or imposition of any Lien upon the Collateral, other than Permitted Liens and the
Liens created by this Agreement and the other Loan Documents, (iii) do not violate any provisions of Borrower’s Certificate or Articles of Incorporation (as applicable), bylaws, or any, law, regulation, order, injunction, judgment, decree
or writ to which Borrower is subject and (iv) except as described on Schedule 5.3 to the Disclosure Letter, do not violate any material contract or agreement or require the consent or approval of any other Person which has not already been
obtained. The individual or individuals executing the Loan Documents and the Warrant are duly authorized to do so. 











 5.4 Material Adverse Effect. Since December 31, 2021, no event that has
had or would reasonably be expected to have a Material Adverse Effect has occurred and is continuing. 
 5.5 Actions Before
Governmental Authorities. There are no actions, suits or proceedings at law or in equity or by or before any governmental authority now pending or, to the knowledge of Borrower, threatened in writing against or affecting Borrower or its property,
that is reasonably expected to result in a Material Adverse Effect. 
 5.6 Laws. Neither Borrower nor any of its Subsidiaries
is in violation of any law, rule or regulation, or in default with respect to any judgment, writ, injunction or decree of any governmental authority to which Borrower or such Subsidiaries are subject, where such violation or default is reasonably
expected to result in a Material Adverse Effect. Borrower is not in default in any manner under any material provision of any agreement or instrument evidencing material Indebtedness, or any other material agreement to which it is a party or by
which it is bound. 
 Neither Borrower nor any of its Subsidiaries is an “investment company” or a company
“controlled” by an “investment company” under the Investment Company Act of 1940, as amended. Neither Borrower nor any of its Subsidiaries is engaged as one of its important activities in extending credit for margin stock (under
Regulations X, T and U of the Federal Reserve Board of Governors). Borrower and each of its Subsidiaries has complied in all material respects with the Federal Fair Labor Standards Act. Neither Borrower nor any of its Subsidiaries is a “holding
company” or an “affiliate” of a “holding company” or a “subsidiary company” of a “holding company” as each term is defined and used in the Public Utility Holding Company Act of 2005. Neither
Borrower’s nor any of its Subsidiaries’ properties or assets have been used by Borrower or such Subsidiary or, to Borrower’s knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous
substance other than in material compliance with applicable laws. Borrower and each of its Subsidiaries has obtained all material consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all
governmental authorities that are necessary to continue their respective businesses as currently conducted. 
 None of
Borrower, any of its Subsidiaries, or, to Borrower’s knowledge, any of Borrower’s or its Subsidiaries’ Affiliates or any of their respective agents acting or benefiting in any capacity in connection with the transactions contemplated
by this Agreement is (i) in violation of any Anti-Terrorism Law, (ii) engaging in or conspiring to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding or attempts to violate, any of the prohibitions
set forth in any Anti-Terrorism Law, or (iii) is a Blocked Person. None of Borrower, any of its Subsidiaries, or to the knowledge of Borrower and any of their Affiliates or agents, acting or benefiting in any capacity in connection with the
transactions contemplated by this Agreement, (x) conducts any business or engages in making or receiving any contribution of funds, goods or services to or for the benefit of any Blocked Person, or (y) deals in, or otherwise engages in any
transaction relating to, any property or interest in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law. None of the funds to be provided under this Agreement shall be used, directly
or indirectly, (a) for any activities in violation of any applicable anti-money laundering, economic sanctions and anti-bribery laws and regulations laws and regulations or (b) for any payment to any governmental official or employee,
political party, official of a political party, candidate for political office, or anyone else acting in an official capacity, in order to obtain, retain or direct business or obtain any improper advantage, in violation of the United States Foreign
Corrupt Practices Act of 1977, as amended. 
 5.7 Information Correct and Current. No written information, report, Advance
Request, financial statement, exhibit or schedule furnished, by or on behalf of Borrower to Agent in 











 
connection with any Loan Document or included therein or delivered pursuant thereto (in each case, other than forecasts, projections and other forward-looking statements and information of a
general economic or industry nature) contained, or, when taken as a whole, contains or will contain any material misstatement of fact or, when taken together with all other such written information or documents, omitted, omits or will omit to state
any material fact necessary to make the statements therein, in the light of the circumstances under which they were, are or will be made, not materially misleading at the time such statement was made or deemed made. Additionally, any and all
financial or business projections provided by Borrower to Agent, whether prior to or after the Closing Date, shall be (i) provided in good faith and based on the most current data and information available to Borrower at the time delivered, and
(ii) the most current of such projections provided to Borrower’s board of directors, provided that it is understood that the forecasts, projections and other forward-looking statements and information of a general economic or industry
nature are based on assumptions made in good faith but are subject to significant uncertainties and contingencies, many of which are beyond the control of Borrower, and that actual results may differ significantly and no assurances are provided by
Borrower for any projections made or given. 
 5.8 Tax Matters. Except as set forth on Schedule 5.8 to the Disclosure Letter,
(a) Borrower and its Subsidiaries have filed all federal and state income Tax returns and other material Tax returns that they are required to file (taking into account any timely filed extensions), (b) Borrower and its Subsidiaries have duly
paid all federal and state income Taxes and other material Taxes or installments thereof that they are required to pay as and when due, except Taxes in an amount not to exceed Fifty Thousand Dollars ($50,000) in the aggregate or being contested in
good faith by appropriate proceedings and for which Borrower and its Subsidiaries maintain adequate reserves in accordance with GAAP, and (c) to the best of Borrower’s knowledge, no proposed or pending Tax assessments, deficiencies, audits
or other proceedings with respect to Borrower or any Subsidiary have had, or could reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect. 

5.9 Intellectual Property Claims. Borrower is the sole owner of, or otherwise has the right to use, the Intellectual Property
material to Borrower’s business. Except as described on Schedule 5.9 to the Disclosure Letter (as may be amended or supplemented by Borrower from time to time by written notice to Agent), (i) each of the material registered Copyrights,
registered Trademarks and issued Patents is valid and enforceable, (ii) no material part of the Intellectual Property has been judged invalid or unenforceable, in whole or in part, and (iii) no claim has been made to Borrower that any
material part of the Intellectual Property violates the rights of any third party. The Perfection Certificate delivered to Agent on the Closing Date includes a true, correct and complete list of each of Borrower’s Patents, registered
Trademarks, registered Copyrights, and material agreements under which Borrower licenses Intellectual Property from third parties (other than shrink-wrap software licenses or other
“off-the-shelf” licenses or open-source software), together with application or registration numbers, as applicable, owned by Borrower or any Subsidiary, in
each case as of the Closing Date. Borrower is not in material breach of, nor has Borrower failed to perform any material obligations under, any of the foregoing contracts, licenses or agreements and, to Borrower’s knowledge, no third party to
any such contract, license or agreement is in material breach thereof or has failed to perform any material obligations thereunder. 

5.10 Intellectual Property. Except as described on Schedule 5.10 to the Disclosure Letter (as may be amended or supplemented by
Borrower from time to time by written notice to Agent), Borrower has all material rights with respect to Intellectual Property necessary or material in the operation or conduct of Borrower’s business as currently conducted and proposed to be
conducted by Borrower. Without limiting the generality of the foregoing, and in the case of Licenses, except for restrictions that are unenforceable under Division 9 of the UCC, Borrower has the right, to the












 
extent required to operate Borrower’s business, to freely transfer, license or assign Intellectual Property necessary or material in the operation or conduct of Borrower’s business as
currently conducted and proposed to be conducted by Borrower, without condition, restriction or payment of any kind (other than license payments in the ordinary course of business) to any third party, and Borrower owns or has the right to use,
pursuant to valid licenses, all software development tools, library functions, compilers and all other third-party software and other items that are material to Borrower’s business and used in the design, development, promotion, sale, license,
manufacture, import, export, use or distribution of Borrower Products except customary covenants in inbound license agreements and equipment leases where Borrower is the licensee or lessee. 

No material software or other materials used by Borrower or any of its Subsidiaries (or used in any Borrower Products or any
Subsidiaries’ products) are subject to an open-source or similar license (including but not limited to the General Public License, Lesser General Public License, Mozilla Public License, or Affero License) (collectively, “Open Source
Licenses”) in a manner that would cause such software or other materials to have to be (i) distributed to third parties at no charge or a minimal charge (royalty-free basis); (ii) licensed to third parties to modify, make derivative works
based on, decompile, disassemble, or reverse engineer; or (iii) used in a manner that requires disclosure or distribution in source code form. 

5.11 Borrower Products. Except as described on Schedule 5.11 to the Disclosure Letter (as may be amended or supplemented by
Borrower from time to time by written notice to Agent), no material Intellectual Property owned by Borrower or Borrower Product has been or is subject to any actual or, to the knowledge of Borrower, threatened litigation in writing, proceeding
(including any proceeding in the United States Patent and Trademark Office or any corresponding foreign office or agency) or outstanding decree, order, judgment, settlement agreement or stipulation that restricts in any material manner
Borrower’s use, transfer or licensing thereof or that could reasonably be expected to adversely affect the validity, use or enforceability thereof. There is no decree, order, judgment, agreement, stipulation, arbitral award or other provision
entered into in connection with any litigation or proceeding that obligates Borrower to grant licenses or ownership interest in any future material Intellectual Property related to the operation or conduct of the business of Borrower or Borrower
Products. Borrower has not received any written notice or claim, or, to the knowledge of Borrower, oral notice or claim, challenging or questioning Borrower’s ownership in any material Intellectual Property (or written notice of any claim
challenging or questioning the ownership in any licensed Intellectual Property of the owner thereof) or suggesting that any third party has any claim of legal or beneficial ownership with respect thereto nor, to Borrower’s knowledge, is there a
reasonable basis for any such claim, in each case to where such notice or claim would reasonably be expected to have a Material Adverse Effect. Neither Borrower’s use of its Intellectual Property nor the production and sale of Borrower Products
infringes the Intellectual Property or other rights of others in any material respect. 
 5.12 Financial Accounts. Schedule
5.12 to the Disclosure Letter, as may be updated by Borrower in a written notice provided to Agent after the Closing Date, is a true, correct and complete list of (a) all banks and other financial institutions at which Borrower or any
Subsidiary maintains Deposit Accounts and (b) all institutions at which Borrower or any Subsidiary maintains an account holding Investment Property, and such exhibit correctly identifies the name, address and telephone number of each bank or
other institution, the name in which the account is held, a description of the purpose of the account, and the complete account number therefor. 

5.13 Employee Loans. Except as permitted hereunder, Borrower has no outstanding loans to any employee, officer or director of
Borrower nor has Borrower guaranteed the payment of any loan made to an employee, officer or director of Borrower by a third party. 











 5.14 Investments and Subsidiaries. Borrower does not own any stock,
partnership interest or other securities of any Person, except for Permitted Investments. Attached as Schedule 1 to the Disclosure Letter, as may be updated by Borrower in a written notice provided after the Closing Date, is a true, correct and
complete list of each Subsidiary. 
 5.15 Regulatory Matters. 

(a) Borrower, each Subsidiary, and to the knowledge of Borrower, their respective directors, officers, employees, and agents
are, and at all times within the last three years have been, in compliance with all applicable Healthcare Laws, except where failures to so comply would not, whether individually or in the aggregate, reasonably be expected to have a Material Adverse
Effect. Borrower has not received any written notification, correspondence, or any other communication from any governmental authority asserting non-compliance by, or liability of, Borrower or any Subsidiary
under any applicable Healthcare Laws, except where such non-compliance would not, whether individually or in the aggregate, reasonably be expected to have a Material Adverse Effect. Borrower is not a party to
or has any ongoing reporting obligations pursuant to or under any order by a governmental authority or corporate integrity agreements, deferred prosecution agreements, monitoring agreements, consent decrees, settlement orders, plans of correction or
similar agreements with or imposed by any governmental authority. 
 Neither Borrower or any Subsidiary, nor any officers, employees or, to
the knowledge of Borrower, agents of Borrower or any Subsidiary has been excluded, suspended or debarred from any government healthcare program or convicted of any crime or engaged in any conduct that would reasonably be expected to result in
debarment under any applicable Healthcare Law, and, to the knowledge of Borrower, no such Action is currently contemplated, proposed or pending. 

(b) Borrower and each Subsidiary has obtained and maintained all Permits, including any Permits required pursuant to any
applicable Healthcare Laws, and all of such Permits are in full force and effect, except where failures to possess or maintain the same, would not, whether individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.
Borrower and each Subsidiary has fulfilled and performed all of its material obligations with respect to the Permits, and, to the knowledge of Borrower, no event has occurred which allows, or after notice or lapse of time would allow, revocation or
termination thereof or result in any other impairment of the rights of the holder of any Permit, except where such revocations, terminations or impairments would not, whether individually or in the aggregate, reasonably be expected to have a
Material Adverse Effect. 
 (c) All clinical or preclinical studies, tests or trials that have been or are being conducted by
or on behalf of, or sponsored by, Borrower or any Subsidiary, or in which Borrower’s or any Subsidiary’s products or product candidates have participated, and which have been or will be submitted to the FDA or other regulatory authorities
in connection with applications for Permits, were and, if still pending, are being conducted in compliance in all material respects with all applicable Healthcare Laws. No investigational new drug application or other allowance to commence a
clinical trial filed with or submitted to the FDA or other governmental authority by or on behalf of Borrower or any Subsidiary has been terminated or suspended by the FDA or other such governmental authority, and neither the FDA nor any applicable
governmental authority has commenced, or to the knowledge of Borrower, threatened to initiate, any action to place a clinical hold order on, or otherwise terminate or suspend, any proposed or ongoing clinical investigation conducted or proposed to
be conducted by or on behalf of Borrower or any Subsidiary. 
 SECTION 6. INSURANCE; INDEMNIFICATION 











 6.1 Coverage. Borrower shall cause to be carried and maintained commercial
general liability insurance, on an occurrence form, against risks customarily insured against by businesses of Borrower’s size in Borrower’s line of business in similar locations. Such risks shall include the risks of bodily injury,
including death, property damage, personal injury, advertising injury, and contractual liability per the terms of the indemnification agreement found in Section 6.3. Borrower must maintain a minimum of $1,000,000 of commercial general liability
insurance for each occurrence and $2,000,000 in the aggregate. Borrower has and agrees to maintain a minimum of $2,000,000 of directors’ and officers’ insurance for each occurrence and $5,000,000 in the aggregate. So long as there are any
Secured Obligations outstanding (other than inchoate indemnification or reimbursement obligations or other obligations which, by their terms, survive termination of this Agreement), Borrower shall also cause to be carried and maintained insurance
upon the Collateral, insuring against special risks of physical loss or damage howsoever caused, in an amount not less than the full replacement cost of the Collateral, provided that such insurance may be subject to standard exceptions and
deductibles. If Borrower fails to obtain the insurance called for by this Section 6.1 or fails to pay any premium thereon or fails to pay any other amount which Borrower is obligated to pay under this Agreement or any other Loan Document or
which may be required to preserve the Collateral, Agent may obtain such insurance or make such payment, and all amounts so paid by Agent are immediately due and payable, bearing interest at the then highest rate applicable to the Secured
Obligations, and secured by the Collateral. Agent will make reasonable efforts to provide Borrower with notice of Agent obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No payments by Agent are
deemed an agreement to make similar payments in the future or Agent’s waiver of any Event of Default. 
 6.2
Certificates. Borrower shall deliver to Agent certificates of insurance that evidence Borrower’s compliance with its insurance obligations in Section 6.1 and the obligations contained in this Section 6.2. Borrower’s insurance
certificate shall state Agent (shown as “Hercules Capital, Inc., as Agent”) is an additional insured for commercial general liability, a lenders loss payable for all risk property damage insurance, subject to the insurer’s approval,
and a lenders loss payable for property insurance and additional insured for liability insurance for any future insurance that Borrower may acquire from such insurer. Attached to the certificates of insurance will be additional insured endorsements
for liability and lender’s loss payable endorsements for all risk property damage insurance. All certificates of insurance will provide for a minimum of thirty (30) days advance written notice to Agent of cancellation (other than
cancellation for non-payment of premiums, for which ten (10) days’ advance written notice shall be sufficient). Any failure of Agent to scrutinize such insurance certificates for compliance is not a
waiver of any of Agent’s rights, all of which are reserved. Borrower shall provide Agent with copies of each insurance policy, and upon entering or amending any insurance policy required hereunder, Borrower shall provide Agent with copies of
such policies and shall promptly deliver to Agent updated insurance certificates with respect to such policies. 
 6.3
Indemnity. Borrower agrees to indemnify and hold Agent, the Lenders and their officers, directors, employees, agents, in-house attorneys, representatives and shareholders (each, an “Indemnified
Person”) harmless from and against any and all third-party claims, reasonable and documented out-of-pocket costs, expenses, damages and liabilities (including such
claims, costs, expenses, damages and liabilities based on liability in tort, including strict liability in tort), including reasonable and documented out-of-pocket
attorneys’ fees and disbursements and other costs of investigation or defense (including those incurred upon any appeal) (collectively, “Liabilities”), that may be instituted or asserted against or incurred by such Indemnified Person
as the result of credit having been extended, suspended or terminated under this Agreement and the other Loan Documents or the administration of such credit, or in connection with or arising out of the transactions contemplated hereunder and
thereunder, or any actions or failures to act in connection therewith, or 











 
arising out of the disposition or utilization of the Collateral, excluding in all cases Liabilities to the extent such Liabilities arise solely out of gross negligence or willful misconduct of
any Indemnified Person or changes in income tax rates. This Section 6.3 shall not apply with respect to Taxes other than any Taxes that represent losses, claims, damages, etc. arising from any non-Tax
claim. In no event shall any Indemnified Person be liable on any theory of liability for any special, indirect, consequential or punitive damages (including any loss of profits, business or anticipated savings). This Section 6.3 shall survive
the repayment of indebtedness under, and otherwise shall survive the expiration or other termination of, this Agreement. 
 SECTION 7.
COVENANTS OF BORROWER 
 Borrower agrees as follows: 

7.1 Financial Reports. Borrower shall furnish to Agent the financial statements and reports listed hereinafter (the
“Financial Statements”): 
 (a) if Borrower’s Market Capitalization is less than Seven Hundred Fifty Million
Dollars ($750,000,000) as of the last day of any calendar month, within thirty (30) days after the end of each month, (x) unaudited interim and year-to-date
financial statements as of the end of such month (prepared on a consolidated and consolidating basis, if applicable), including balance sheet and related statements of income and cash flows, all certified by Borrower’s Chief Executive Officer
or principal accounting officer to the effect that they have been prepared in accordance with GAAP, except (i) for the absence of footnotes, (ii) that they are subject to normal year-end adjustments,
and (iii) they do not contain certain non-cash items that are customarily included in quarterly and annual financial statements and (y) a Compliance Certificate in the form of Exhibit E; 

(b) if Borrower’s Market Capitalization is equal to or greater than Seven Hundred Fifty Million Dollars ($750,000,000) as
of the last day of any calendar month, within, forty-five (45) days) after the end of each quarter of each fiscal year, (x) unaudited interim and year-to-date
financial statements as of the end of such calendar quarter (prepared on a consolidated and consolidating basis, if applicable), including balance sheet and related statements of income and cash flows accompanied by a report detailing any material
contingencies (including the commencement of any material litigation by or against Borrower) or any other occurrence that would reasonably be expected to have a Material Adverse Effect, certified by Borrower’s Chief Executive Officer or
principal accounting officer to the effect that they have been prepared in accordance with GAAP, except (i) for the absence of footnotes, and (ii) that they are subject to normal year-end adjustments
and (y) a Compliance Certificate in the form of Exhibit E; 
 (c) within ninety (90) days after the end of each
fiscal year, (x) unqualified (other than a going concern qualification based on Borrower having negative profits or based on a determination that Borrower has less than twelve (12) months liquidity) audited financial statements as of the
end of such year (prepared on a consolidated and consolidating basis, if applicable), including balance sheet and related statements of income and cash flows, and setting forth in comparative form the corresponding figures for the preceding fiscal
year, certified by a firm of independent certified public accountants selected by Borrower and reasonably acceptable to Agent (provided that Borrowers’ accounting firm as of the Closing Date, and any other nationally recognized accounting firm,
shall be acceptable), accompanied by any management report from such accountants and (y) a Compliance Certificate in the form of Exhibit E; 











 (d) within 10 days after the end of each month, a summary of the account
balances of each of Borrower’s Deposit Accounts as of the last day of such month, delivered by email to Lake McGuire at lmcguire@htgc.com or to such successor Person(s) as Agent may designate in writing from time to time; 

(e) promptly after the sending or filing thereof, as the case may be, copies of any proxy statements, financial statements or
reports that Kura Oncology has made generally available to holders of its common stock and copies of any regular, periodic and special reports or registration statements that Kura Oncology files with the Securities and Exchange Commission or any
governmental authority that may be substituted therefor, or any national securities exchange; 
 (f) together with the
Compliance Certificate delivered following the end of each fiscal quarter of Borrower, copies of all notices, minutes, consents and other materials that Kura Oncology provided to its directors in connection with meetings of Kura Oncology’s
board of directors during such fiscal quarter; provided that in all cases Kura Oncology may exclude (i) confidential compensation and personnel employment information, (ii) materials that are related to Kura Oncology’s
strategy, negotiating position or other matters materially relating to this Agreement or any other Loan Documents or any permitted refinancings thereof, and (iii) such information is subject to attorney-client privilege with respect to pending
or threatened litigation; 
 (g) Borrower’s annual budget for each fiscal year, promptly following its approval by Kura
Oncology’s board of directors, and in any event, on or prior to the date that is 60 days after the start of such fiscal year; 

(h) notice of any Commercial Tort Claim or
Letter-of-Credit Rights held by Borrower or any Guarantor, in each case in an amount greater than Five Hundred Thousand Dollars ($500,000), and of the general details
thereof; and 
 (i) prompt (but in any event within two (2) Business Days) notice if Borrower or any
Subsidiary has knowledge that Borrower, or any Subsidiary or Affiliate of Borrower, is listed on the OFAC Lists or (a) is convicted on, (b) pleads nolo contendere to, (c) is indicted on, or (d) is arraigned and held over
on charges involving money laundering or predicate crimes to money laundering. 
 The executed Compliance Certificate and all Financial
Statements required to be delivered pursuant to this Section 7.1 shall be sent via e-mail to financialstatements@htgc.com with a copy to legal@htgc.com and cbarnes@htgc.com, bgironda@htgc.com and
lmcguire@htgc.com provided, that if e-mail is not available or sending such Financial Statements via e-mail is not possible, they shall be faxed to Agent at: (650) 473-9194, attention Account Manager: Kura Oncology, Inc. 
 Notwithstanding the foregoing, documents
required to be delivered under Sections 7.1(a), (b), (c) and (e) (to the extent any such documents are included in materials otherwise filed with the SEC) may be delivered electronically and if so delivered, shall be deemed to have been delivered on
the date on which (i) Borrower emails a link thereto to Agent or (ii) Borrower files any such documents with the SEC and such documents are publicly available on the SEC’s EDGAR filing system or any successor thereto. 

7.2 Management Rights. Borrower shall permit any representative that Agent or the Lenders authorizes, including its attorneys
and accountants, to inspect the Collateral and examine and make copies and abstracts of the books of account and records of Borrower at reasonable times and upon reasonable notice during normal business hours; provided, however, that so long
as no Event of Default has occurred and is continuing, such examinations shall be limited to no more often 











 
than once per fiscal year. In addition, in connection with such inspections and upon reasonable two (2) Business Days’ prior written notice, any such representative shall have the right
to meet with management and officers of Borrower to discuss such books of account and records. In addition, Agent or the Lenders shall be entitled at reasonable times and intervals and upon reasonable two (2) Business Days’ prior written
notice to consult with and advise the management and officers of Borrower concerning significant business issues affecting Borrower. Such consultations shall not unreasonably interfere with Borrower’s business operations. The parties intend
that the rights granted Agent and the Lenders shall constitute “management rights” within the meaning of 29 C.F.R. Section 2510.3-101(d)(3)(ii), but that any advice, recommendations or
participation by Agent or the Lenders with respect to any business issues shall not be deemed to give Agent or the Lenders, nor be deemed an exercise by Agent or the Lenders of, control over Borrower’s management or policies. 

7.3 Further Assurances. Borrower shall from time to time execute, deliver and file, alone or with Agent, any financing
statements, security agreements, collateral assignments, notices, control agreements, promissory notes or other documents to perfect, give the highest priority to Agent’s Lien on the Collateral (subject to Permitted Liens) or otherwise evidence
Agent’s rights herein. Borrower shall from time to time procure any instruments or documents as may be reasonably requested by Agent, and take all further action that may be necessary, or that Agent may reasonably request, to perfect and
protect the Liens granted hereby and thereby in accordance with the Loan Documents. If Borrower shall at any time acquire a Commercial Tort Claim, Borrower shall grant to the Agent a security interest therein and in the proceeds thereof pursuant to
documentation to be in form and substance satisfactory to Agent. In addition, and for such purposes only, Borrower hereby authorizes Agent to execute and deliver on behalf of Borrower and to file such financing statements (including an indication
that the financing statement covers “all assets or all personal property other than intellectual property” of Borrower in accordance with Section 9-504 of the UCC), collateral assignments,
notices, control agreements, security agreements and other documents without the signature of Borrower either in Agent’s name or in the name of Agent as agent and
attorney-in-fact for Borrower. Borrower shall protect and defend Borrower’s title to the Collateral and Agent’s Lien thereon against all Persons claiming any
interest adverse to Borrower or Agent other than Permitted Liens. 
 7.4 Indebtedness. Borrower shall not create, incur,
assume, guarantee or be or remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness, or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any
Indebtedness, except for (a) the conversion of Indebtedness into equity securities and the payment of cash in lieu of fractional shares in connection with such conversion, (b) purchase money Indebtedness pursuant to its then applicable
payment schedule, (c) prepayment by any Subsidiary of (i) intercompany Indebtedness owed by such Subsidiary to any Borrower, or (ii) if such Subsidiary is not a Borrower, intercompany Indebtedness owed by such Subsidiary to another
Subsidiary that is not a Borrower, (d) prepayment of Indebtedness permitted under clauses (i), (iii), (iv), (vii), (ix), (xiv), (xviii) and (xix) of the definition of Permitted Indebtedness, or (e) as otherwise permitted hereunder or
approved in writing by Agent. 
 Notwithstanding anything to the contrary in the foregoing, the issuance of, performance of obligations under
(including any payments of interest), and conversion, exercise, repurchase, redemption (including, for the avoidance of doubt, the redemption of Permitted Convertible Debt upon satisfaction of a condition related to the stock price of the Common
Stock), settlement or early termination or cancellation of (whether in whole or in part and including by netting or set-off) (in each case, whether in cash, Common Stock, any combination thereof or, following
a merger event or other change of the Common Stock, other securities or property), or the satisfaction of any 











 
condition that would permit or require any of the foregoing, any Permitted Convertible Debt shall not constitute a prepayment of Indebtedness by Borrower for the purposes of this
Section 7.4; provided that principal payments in cash (other than cash in lieu of fractional shares) shall only be allowed if the Redemption Conditions are satisfied in respect of such payment; provided further that, to the extent
both (a) the aggregate amount of cash payable upon conversion or payment of any Permitted Convertible Debt (excluding any required payment of interest with respect to such Permitted Convertible Debt and excluding any payment of cash in lieu of
a fractional share due upon conversion thereof) exceeds the aggregate principal amount thereof and (b) such conversion or payment does not trigger or correspond to an exercise or early unwind or settlement of a corresponding portion of the
Permitted Bond Hedge Transactions relating to such Permitted Convertible Debt (including, for the avoidance of doubt, the case where there is no Permitted Bond Hedge Transaction relating to such Permitted Convertible Debt), the payment of such
excess cash shall not be permitted by the preceding sentence. 
 Notwithstanding the foregoing and anything else to the contrary in this
Agreement, Borrower may repurchase, exchange or induce the conversion of Permitted Convertible Debt by delivery of shares of Common Stock and/or a different series of Permitted Convertible Debt and/or by payment of cash (in an amount that does not
exceed the proceeds received by Borrower from the substantially concurrent issuance of Common Stock and/or Permitted Convertible Debt plus the net cash proceeds, if any, received by Borrower pursuant to the related exercise or early unwind or
termination of the related Permitted Bond Hedge Transactions and Permitted Warrant Transactions, if any, pursuant to the immediately following proviso plus any accrued and unpaid interest on such Permitted Convertible Debt). 

7.5 Collateral. Borrower shall at all times (a) keep the Collateral, the Intellectual Property and all other property and
assets used in Borrower’s business or in which Borrower now or hereafter holds any interest free and clear from any legal process or Liens whatsoever (except for Permitted Liens), and (b) shall give Agent prompt written notice of any known
legal process adverse to the Collateral, the Intellectual Property, or such other property and assets, in each case, with a value in excess of Five Hundred Thousand Dollars ($500,000), or any Liens thereon, provided however, that the Collateral and
such other property and assets may be subject to Permitted Liens except that there shall be no Liens whatsoever on Intellectual Property (except for Permitted Liens). Borrower shall not agree with any Person other than Agent or the Lenders not to
encumber its property other than in connection with Permitted Liens. Borrower shall not enter into or suffer to exist or become effective any agreement that prohibits or limits the ability of any Borrower to create, incur, assume or suffer to exist
any Lien upon any of its property (including Intellectual Property), whether now existing or hereafter acquired, to secure its obligations under the Loan Documents to which it is a party other than (a) this Agreement and the other Loan
Documents, (b) any agreements governing any purchase money Liens or capital lease obligations otherwise permitted hereby (in which case, any prohibition or limitation shall only be effective against the assets financed thereby), (c) any
Permitted License, and (d) customary restrictions on the assignment, sublicense or sublease of leases, licenses and other agreements. Borrower shall cause its Subsidiaries to protect and defend such Subsidiary’s title to its assets from
and against all Persons claiming any interest adverse to such Subsidiary, and Borrower shall cause its Subsidiaries at all times to keep such Subsidiary’s property and assets free and clear from any known legal process or Liens whatsoever
(except for Permitted Liens), and shall give Agent prompt written notice of any legal process adverse to such Subsidiary’s assets, in each case, with a value in excess of One Million Dollars ($1,000,000). 

7.6 Investments. Borrower shall not directly or indirectly acquire or own, or make any Investment in or to any Person, or
permit any of its Subsidiaries to do so, other than Permitted Investments. 











 Notwithstanding the foregoing, and for the avoidance of doubt, this Section 7.6 shall
not prohibit the conversion by holders of (including any payment upon conversion, whether in cash, Common Stock or a combination thereof), or required payment of any principal or premium on (including, for the avoidance of doubt, the redemption of
Permitted Convertible Debt upon satisfaction of any condition related to the stock price of Borrower’s Common Stock) or required payment of any interest with respect to, any Permitted Convertible Debt in each case, in accordance with the terms
of the indenture or other instrument governing such Permitted Convertible Debt; provided that, to the extent both (a) the aggregate amount of cash payable upon conversion or payment of any Permitted Convertible Debt (excluding any required
payment of interest with respect to such Permitted Convertible Debt and excluding any payment of cash in lieu of a fractional share due upon conversion thereof) exceeds the aggregate principal amount thereof and (b) such conversion or payment
does not trigger or correspond to an exercise or early unwind or settlement of a corresponding portion of the Permitted Bond Hedge Transactions relating to such Permitted Convertible Debt (including, for the avoidance of doubt, the case where there
is no Permitted Bond Hedge Transaction relating to such Permitted Convertible Debt), the payment of such excess cash shall not be permitted by the preceding sentence; provided further that principal payments in cash (other than cash in lieu of
fractional shares) shall only be allowed if the Redemption Conditions are satisfied in respect of such redemption. 
 7.7
Distributions. Borrower shall not, and shall not allow any Subsidiary to, (a) repurchase or redeem any class of stock or other Equity Interest other than (i) pursuant to employee, officer, director or consultant repurchase plans or other
similar agreements, provided, however, in each case the repurchase or redemption price does not exceed the original consideration paid for such stock or Equity Interest, (ii) repurchases of such shares, stock or Equity Interest deemed to occur
upon exercise of stock options or warrants if such repurchased shares, stock or Equity Interest represents a portion of the exercise price of such options or warrants, (iii) repurchases of such shares, stock or Equity Interest deemed to occur
upon the withholding of a portion of such shares, stock or Equity Interest granted or awarded to a current or former officer, director, employee or consultant to pay for the Taxes payable by such Person upon such grant or award (or upon vesting
thereof), (iv) purchases of capital stock pledged as collateral for loans to employees, provided that such purchases do not exceed One Hundred Thousand Dollars ($100,000) in the aggregate, (v) purchases of fractional shares of capital stock
arising out of stock dividends, splits or combinations or business combinations or in connection with exercises or conversions of options, warrants and other convertible securities, (vi) the payment of the net purchase price in respect of any
Permitted Bond Hedge Transaction with the proceeds of the issuance of Permitted Convertible Debt and (vii) the settlement, unwind or other termination of all or any portion of any Permitted Warrant Transaction by
(x) set-off against the concurrent settlement, unwind or other termination of all or any portion of any Permitted Bond Hedge Transaction or (y) delivery of shares of Common Stock, or (b) declare
or pay any cash dividend or make any other cash distribution on any class of stock or other Equity Interest, except that a Subsidiary may pay dividends or make other distributions to Borrower or any Subsidiary of Borrower, or (c) (A) other than
Permitted Investments, lend money to any employees, officers or directors or (B) guarantee the payment of any such loans granted by a third party in excess of $100,000 in the aggregate, or (d) waive, release or forgive any Indebtedness
owed by any employees, officers or directors in excess of $100,000 in the aggregate. 
 Notwithstanding the foregoing, and for the avoidance
of doubt, this Section 7.7 shall not prohibit the conversion by holders of (including any payment upon conversion, whether in cash, Common Stock or a combination thereof), or required payment of any principal or premium on (including, for the
avoidance of doubt, in respect of the redemption of Permitted Convertible Debt upon satisfaction of a condition related to the stock price of the Common Stock) or required payment of any interest with respect to, any Permitted Convertible Debt in
each case, in accordance with the terms of the 











 
indenture governing such Permitted Convertible Debt; provided that principal payments in cash (other than cash in lieu of fractional shares) shall only be allowed if the Redemption Conditions are
satisfied in respect of such payment; provided further that, to the extent both (a) the aggregate amount of cash payable upon conversion or payment of any Permitted Convertible Debt (excluding any required payment of interest with respect to
such Permitted Convertible Debt and excluding any payment of cash in lieu of a fractional share due upon conversion thereof) exceeds the aggregate principal amount thereof and (b) such conversion or payment is not offset by an exercise or early
unwind or settlement of a corresponding portion of the Permitted Bond Hedge Transactions relating to such Permitted Convertible Debt (including, for the avoidance of doubt, the case where there is no Permitted Bond Hedge Transaction relating to such
Permitted Convertible Debt), the payment of such excess cash shall not be permitted by the preceding sentence. 
 Notwithstanding the
foregoing and anything else to the contrary in this Agreement, Borrower may repurchase, exchange or induce the conversion of Permitted Convertible Debt by delivery of shares of Common Stock and/or a different series of Permitted Convertible Debt
and/or by payment of cash (in an amount that does not exceed the proceeds received by Borrower from the substantially concurrent issuance of Common Stock and/or Permitted Convertible Debt plus the net cash proceeds, if any, received by Borrower
pursuant to the related exercise or early unwind or termination of the related Permitted Bond Hedge Transactions and Permitted Warrant Transactions, if any, pursuant to the immediately following proviso plus any accrued and unpaid interest on such
Permitted Convertible Debt). 
 Notwithstanding the foregoing, and for the avoidance of doubt, this Section 7.7 shall not prohibit
(x) Borrower’s entry into (including the payment of premium) any Permitted Bond Hedge Transaction (or the settlement or termination thereof) or (y) Borrower’s settlement of any Permitted Warrant Transaction by (i) delivery
of shares of Common Stock or (ii) netting or set-off against the related Permitted Bond Hedge Transaction. 

7.8 Transfers. Except for Permitted Transfers, Borrower shall not, and shall not allow any Subsidiary to, voluntarily or
involuntarily transfer, sell, lease, license, lend or in any other manner convey any equitable, beneficial or legal interest in any material portion of its assets. 

7.9 Mergers and Consolidations. Borrower shall not merge or consolidate, or permit any of its Subsidiaries to merge or
consolidate, with or into any other business organization (other than mergers or consolidations of (a) a Subsidiary which is not a Borrower into another Subsidiary or into Borrower or (b) a Borrower into another Borrower), or enter into
any Acquisition, other than Permitted Acquisitions. 
 7.10 Taxes. Borrower shall, and shall cause each of its Subsidiaries
to, pay when due all Taxes of any nature whatsoever now or hereafter imposed or assessed against Borrower or such Subsidiary or the Collateral or upon Borrower’s (or such Subsidiary’s) ownership, possession, use, operation or disposition
thereof or upon Borrower’s (or such Subsidiary’s) rents, receipts or earnings arising therefrom, other than such Taxes that do not, individually or in the aggregate, exceed Fifty Thousand Dollars ($50,000). Borrower shall, and shall cause
each of its Subsidiaries to, accurately file on or before the due date therefor (taking into account proper extensions) all federal and state income Tax returns and other material Tax returns required to be filed. Notwithstanding the foregoing,
Borrower and its Subsidiaries may contest, in good faith and by appropriate proceedings diligently conducted, Taxes for which Borrower and its Subsidiaries maintain adequate reserves in accordance with GAAP. 











 7.11 Corporate Changes. Neither Borrower nor any Subsidiary shall change its
corporate name, legal form or jurisdiction of formation without fifteen (15) days’ prior written notice to Agent. Neither Borrower nor any Subsidiary shall suffer a Change in Control or engage in or permit any of its Subsidiaries to engage
in any business other than the businesses engaged in by Borrower as of the Closing Date or any business similar, reasonably related or complementary thereto. Neither Borrower nor any Subsidiary shall relocate its chief executive office or its
principal place of business unless: (i) it has provided prior written notice to Agent; and (ii) such relocation shall be within the continental United States of America. Neither Borrower nor any Subsidiary shall relocate any tangible items
of Collateral (other than (v) relocations of Collateral temporarily for sales, testing or demonstration purposes in the ordinary course of business, (w) relocations of biopharmaceutical compounds and therapeutic materials in the ordinary
course of business in connection with clinical trials and development arrangements, (x) sales of Inventory in the ordinary course of business, (y) relocations of Equipment having an aggregate value of up to Five Hundred Thousand Dollars
($500,000) in any fiscal year, and (z) relocations of Collateral from a location described on Schedule 5.1 to the Disclosure Letter to another location described on Schedule 5.1 to the Disclosure Letter) unless (i) it has provided prompt
written notice to Agent, (ii) such relocation is within the continental United States of America and, (iii) if such relocation is to a landlord or third party bailee, it has delivered a landlord waiver and consent or a bailee agreement, as
the case may be, in form and substance reasonably acceptable to Agent. 
 7.12 Deposit Accounts. Neither Borrower nor any
Subsidiary shall maintain any Deposit Accounts, or accounts holding Investment Property, except with respect to which Agent has an Account Control Agreement, provided that no Account Control Agreement shall be required for any Excluded Account. 

7.13 Future Subsidiaries. Borrower shall notify Agent of each Subsidiary formed subsequent to the Closing Date and, within
fifteen (15) days of formation, shall cause any such Subsidiary to execute and deliver to Agent a Joinder Agreement. 

7.14 Notification of Event of Default. Borrower shall notify Agent promptly, and in any case within two (2) Business Days
of Borrower obtaining knowledge, of the occurrence of any Event of Default. 
 7.15 One or more affiliates of Agent have
received a license from the U.S. Small Business Administration (“SBA”) to extend loans as a small business investment company (“SBIC”) pursuant to the Small Business Investment Act of 1958, as amended, and the associated
regulations (collectively, the “SBIC Act”). Portions of the Loan to Borrower may be by a Lender that is a SBIC. Addendum 2 to this Agreement outlines various responsibilities of Agent, each Lender and Borrower associated with a loan made
by a SBIC, and such Addendum 2 is hereby incorporated in this Agreement. 
 7.16 Use of Proceeds. Borrower agrees that the
proceeds of the Loans shall be used solely to refinance existing indebtedness, to pay related fees and expenses in connection with this Agreement and for working capital and general corporate purposes. The proceeds of the Loans will not be used in
violation of Anti-Corruption Laws or applicable Sanctions. 
 7.17 [RESERVED]. 

7.18 Compliance with Laws. 











 Borrower shall maintain, and shall cause its Subsidiaries to maintain,
compliance in all material respects with all applicable laws, rules or regulations (including any law, rule or regulation with respect to the making or brokering of loans or financial accommodations), and shall, or cause its Subsidiaries to, obtain
and maintain all required material governmental authorizations, approvals, licenses, franchises, permits or registrations reasonably necessary in connection with the conduct of Borrower’s business. 

Neither Borrower nor any of its Subsidiaries shall, nor shall Borrower or any of its Subsidiaries permit any Affiliate to,
directly or indirectly, knowingly enter into any documents, instruments, agreements or contracts with any Person listed on the OFAC Lists. Neither Borrower nor any of its Subsidiaries shall, nor shall Borrower or any of its Subsidiaries, permit any
Affiliate to, directly or indirectly, (i) conduct any business or engage in any transaction or dealing with any Blocked Person, including, without limitation, the making or receiving of any contribution of funds, goods or services to or for the
benefit of any Blocked Person, (ii) deal in, or otherwise engage in any transaction relating to, any property or interests in property blocked pursuant to Executive Order No. 13224 or any similar executive order or other Anti-Terrorism Law, or (iii) engage in or conspire to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding, or attempts to violate, any of the prohibitions set forth in
Executive Order No. 13224 or other Anti-Terrorism Law. 
 Borrower has
implemented and maintains in effect policies and procedures designed to ensure compliance by Borrower, its Subsidiaries and their respective directors, officers, employees and agents with Anti-Corruption Laws and applicable Sanctions, and Borrower,
its Subsidiaries and their respective officers and employees and to the knowledge of Borrower its directors and agents, are in compliance with Anti-Corruption Laws and applicable Sanctions in all material respects. 

None of Borrower, any of its Subsidiaries or any of their respective directors, officers or employees, or to the knowledge of
Borrower, any agent for Borrower or its Subsidiaries that will act in any capacity in connection with or benefit from the credit facility established hereby, is a Sanctioned Person. No Loan, use of proceeds or other transaction contemplated by this
Agreement will violate Anti-Corruption Laws or applicable Sanctions. 
 7.19 Financial Covenants. 

(a) Minimum Cash. 

(i) Commencing June 1, 2024, Borrower shall maintain Qualified Cash in an amount greater than or equal to (x) if
Borrower has not yet achieved the Approval Milestone, fifty-five percent (55%) of the outstanding Secured Obligations or (y) if Borrower has achieved the Approval Milestone, thirty-five percent (35%) of the outstanding Secured Obligations,
inclusive of any Qualified Cash amounts maintained in accordance with Section 7.19(a)(ii) and (iii). 
 (ii) At all
times after the consummation of and prior to the termination of any Corporate Collaboration described in clause (d)(z) of the definition of Permitted License, Borrower shall maintain Qualified Cash in an amount greater than or equal to fifty-five
percent (55%) of the outstanding Secured Obligations, inclusive of any Qualified Cash amounts maintained in accordance with Section 7.19(a)(i) and (iii). 

(iii) If Borrower makes any cash payment in respect of Permitted Convertible Debt subject to satisfaction of the Redemption
Conditions, Borrower shall, at all times 











 
thereafter, maintain Qualified Cash in the amount required by the defined term “Redemption Conditions”, inclusive of any Qualified Cash amounts maintained in accordance with
Section 7.19(a)(i) and (ii). 
 Notwithstanding the foregoing, Section 7.19(a)(i) shall cease to apply during any
period in which Borrower’s Market Capitalization is equal to or greater than One Billion Two Hundred Fifty Million Dollars ($1,250,000,000). 

7.20 Intellectual Property. Each Borrower shall (i) protect, defend and maintain the validity and enforceability of its
material Intellectual Property; (ii) promptly advise Agent in writing of material infringements known to Borrower of its Intellectual Property; and (iii) not allow any Intellectual Property material to Borrowers’ business to be
abandoned, forfeited or dedicated to the public without Agent’s written consent, in each case subject to Borrower’s reasonable discretion and standard commercial practices. 

7.21 Transactions with Affiliates. Borrower shall not and shall not permit any Subsidiary to, directly or indirectly, enter
into or permit to exist any transaction of any kind with any Affiliate of Borrower or such Subsidiary on terms that are less favorable to Borrower or such Subsidiary, as the case may be, than those that might be obtained in an arm’s length
transaction from a Person who is not an Affiliate of Borrower or such Subsidiary other than (i) Permitted Investments, (ii) reasonable and customary fees paid to members of the board, and (iii) board-approved compensation arrangements
for officers and other employees. 
 SECTION 8. RIGHT TO INVEST 

8.1 To the extent consistent with applicable securities laws (including gun jumping prohibitions), Borrower shall provide (or
in the case of a Subsequent Financing that is a registered offering, Borrower shall use its commercially reasonable efforts to provide) the Lenders or their permitted assignees or nominees, designated as such in writing to Borrower, the opportunity,
in their discretion, to participate in each Subsequent Financing in an amount, in the aggregate for all Lenders and their permitted assignees or nominees, of up to Ten Million Dollars ($10,000,000), less any amounts previously invested by the
Lenders or their permitted assignees or nominees pursuant to this Section 8.1, in such Subsequent Financing on the same terms, conditions and pricing afforded to other investors participating in such Subsequent Financing; provided that the
Lenders and their permitted assignees or nominees may not, collectively, invest more than five percent (5%) of the total amount offered in each such Subsequent Financing. If the Lenders (or their permitted assignees or nominees) elect to participate
in any Subsequent Financing, the Lenders (or their permitted assignees or nominees, as applicable) participating in such Subsequent Financing agree to become a party to the agreements executed by the other investors participating in such Subsequent
Financing, including with respect to obligations of confidentiality or as may otherwise be required by the Securities Act of 1933, as amended, and the rules and regulations promulgated by the Securities and Exchange Commission thereunder. Borrower,
or an investment bank or underwriter engaged on Borrower’s behalf, shall provide the Lenders or their permitted assignees or nominees at least three (3) Business Days’ written notice of any planned Subsequent Financing and the
opportunity to exercise the right to invest under this Section 8.1 with respect to any such Subsequent Financing. This Section 8.1, and all rights and obligations hereunder, shall terminate upon the earliest to occur of
(a) termination of this Agreement or (b) such time that the Lenders or their permitted assignees or nominees have purchased $10,000,000 of Borrower’s Equity Interests in the aggregate in Subsequent Financings. 

SECTION 9. EVENTS OF DEFAULT 











 The occurrence of any one or more of the following events shall be an Event
of Default: 
 9.1 Payments. Borrower fails to pay any amount due under this Agreement or any of the other Loan Documents on
the due date; provided, however, that an Event of Default shall not occur on account of a failure to pay due solely to an administrative or operational error of Agent or the Lenders or Borrower’s bank if Borrower had the funds to make the
payment when due and makes the payment within three (3) Business Days following Borrower’s knowledge of such failure to pay; or 

9.2 Covenants. Borrower breaches or defaults in the performance of any covenant or Secured Obligation under this Agreement, or
any of the other Loan Documents, and (a) with respect to a default under any covenant under this Agreement (other than under Sections 6, 7.1, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 7.10, 7.11, 7.12, 7.13, 7.14, 7.16, 7.18, 7.19, 7.20, and 7.21) or any
other Loan Document, such default continues for more than thirty (30) days after the earlier of the date on which (i) Agent or the Lenders have given notice of such default to Borrower and (ii) Borrower has actual knowledge of such
default or (b) with respect to a default under any of Sections 6, 7.1, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 7.10, 7.11, 7.12, 7.13, 7.14, 7.16, 7.18, 7.19, 7.20, and 7.21, the occurrence of such default; or 

9.3 Material Adverse Effect. A circumstance has occurred that constitutes a Material Adverse Effect; provided that, solely for
purposes of this Section 9.3, the following events shall not, in each case in and of itself, constitute a Material Adverse Effect: (a) a change in or discontinuation of a strategic partnership or other collaboration or license arrangement
so long as the same does not affect the ability of Borrower to perform the Secured Obligations or (b) failure to achieve the Approval Milestone, Tranche 2 Milestone or Tranche 3 Milestone so long as the same does not affect the ability of
Borrower to perform the Secured Obligations; or 
 9.4 Representations. Any representation or warranty made by Borrower in
any Loan Document or in the Warrant shall have been false or misleading in any material respect when made or when deemed made; or 

9.5 Insolvency. Borrower (A) (i) shall make an assignment for the benefit of creditors; or (ii) shall be unable to
pay its debts as they become due, or be unable to pay or perform under the Loan Documents, or shall become insolvent; or (iii) shall file a voluntary petition in bankruptcy; or (iv) shall file any petition, answer, or document seeking for
itself any reorganization, arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future statute, law or regulation pertinent to such circumstances; or (v) shall seek or consent to or acquiesce
in the appointment of any trustee, receiver, or liquidator of Borrower or of all or any substantial part (i.e., 33-1/3% or more) of the assets or property of Borrower; or (vi) shall cease operations of
its business as its business has normally been conducted, or terminate substantially all of its employees; or (vii) Borrower or its directors or majority shareholders shall take any action initiating any of the foregoing actions described in
clauses (i) through (vi); or (B) either (i) forty-five (45) days shall have expired after the commencement of an involuntary action against Borrower seeking reorganization, arrangement, composition, readjustment, liquidation,
dissolution or similar relief under any present or future statute, law or regulation, without such action being dismissed or all orders or proceedings thereunder affecting the operations or the business of Borrower being stayed; or (ii) a stay
of any such order or proceedings shall thereafter be set aside and the action setting it aside shall not be timely appealed; or (iii) Borrower shall file any answer admitting or not contesting the material allegations of a petition filed
against Borrower in any such proceedings; or (iv) the court in which such proceedings are pending shall enter a decree or order granting the relief sought in any such proceedings; or (v) forty-five (45) days shall have expired after
the appointment, without the 











 
consent or acquiescence of Borrower, of any trustee, receiver or liquidator of Borrower or of all or any substantial part of the properties of Borrower without such appointment being vacated; or

 9.6 Attachments; Judgments. Any material portion of Borrower’s assets is attached or seized, or a levy is filed
against any such assets, or a judgment or judgments by a court of competent jurisdiction is or are entered for the payment of money (not covered by independent third party insurance as to which liability has not been rejected by such insurance
carrier), individually or in the aggregate, of at least $1,000,000 and such judgement remains unsatisfied, unvacated or unstayed for a period of forty-five (45) days after the entry thereof, or Borrower is enjoined or in any way prevented by
court order from conducting any material part of its business; or 
 9.7 Other Obligations. The occurrence and continuation
of any default that exists beyond any applicable grace and/or cure periods under any agreement or obligation of Borrower involving any Indebtedness in excess of $1,000,000 which has resulted in a right by the holder of such Indebtedness, whether
exercised or not, to accelerate the maturity of such Indebtedness, or the event that any early payment is required or unwinding or termination occurs with respect to any Permitted Bond Hedge Transaction or Permitted Warrant Transaction, or any
condition giving rise to the foregoing is met, in each case, with respect to which Borrower or its Affiliate is the “affected party” or “defaulting party” under the terms of such Permitted Bond Hedge Transaction or Permitted
Warrant Transaction, if a Material Adverse Effect would reasonably be expected to result from such default, early payment, unwinding or termination. 

SECTION 10. REMEDIES 

10.1 General. Upon the occurrence and during the continuance of any one or more Events of Default, to the extent not prohibited
by applicable law, Agent may, and at the direction of the Required Lenders shall, accelerate and demand payment of all or any part of the Secured Obligations together with a Prepayment Charge and declare them to be immediately due and payable
(provided, that upon the occurrence of an Event of Default of the type described in Section 9.5, all of the outstanding Secured Obligations (including, without limitation, the Prepayment Charge and the End of Term Charge) shall automatically be
accelerated and made due and payable, in each case without any further notice or act). Borrower hereby irrevocably appoints Agent as its lawful attorney-in-fact
to: only exercisable following the occurrence and during the continuance of an Event of Default, (i) sign Borrower’s name on any invoice or bill of lading for any account or drafts against account debtors; (ii) demand, collect,
sue, and give releases to any account debtor for monies due, settle and adjust disputes and claims about the accounts directly with account debtors, and compromise, prosecute, or defend any action, claim, case, or proceeding about any Collateral
(including filing a claim or voting a claim in any bankruptcy case in Agent’s or Borrower’s name, as Agent may elect); (iii) make, settle, and adjust all claims under Borrower’s insurance policies; (iv) pay, contest or settle any
Lien, charge, encumbrance, security interest, or other claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; (v) transfer the Collateral into the name of Agent or a third
party as the UCC permits; and (vi) receive, open and dispose of mail addressed to Borrower; (vii) endorse Borrower’s name on any checks, payment instruments, or other forms of payment or security; and (viii) notify all account
debtors to pay Agent directly. Borrower hereby appoints Agent as its lawful attorney-in-fact to sign Borrower’s name on any documents necessary to perfect or
continue the perfection of Agent’s security interest in the Collateral regardless of whether an Event of Default has occurred until all outstanding Secured Obligations have been satisfied in full and the Loan Documents (other than the Warrant)
have been terminated. Agent’s foregoing appointment as Borrower’s attorney in fact, and all of Agent’s rights and powers, coupled with an interest, are irrevocable until all Secured Obligations (other than inchoate indemnity or
reimbursement obligations and any other obligations 











 
which, by their terms, are to survive the termination of this Agreement) have been fully repaid and performed and the Loan Documents (other than the Warrant) have been terminated. Agent may, and
at the direction of the Required Lenders shall, exercise all rights and remedies with respect to the Collateral under the Loan Documents or otherwise available to it under the UCC and other applicable law, including the right to release, hold, sell,
lease, liquidate, collect, realize upon, or otherwise dispose of all or any part of the Collateral and the right to occupy, utilize, process and commingle the Collateral. All Agent’s rights and remedies shall be cumulative and not exclusive.

 10.2 Collection; Foreclosure. Upon the occurrence and during the continuance of any Event of Default, Agent may, and at
the direction of the Required Lenders shall, at any time or from time to time, apply, collect, liquidate, sell in one or more sales, lease or otherwise dispose of, any or all of the Collateral, in its then condition or following any commercially
reasonable preparation or processing, in such order as Agent may elect. Any such sale may be made either at public or private sale at its place of business or elsewhere. Borrower agrees that any such public or private sale may occur upon ten
(10) calendar days’ prior written notice to Borrower. Agent may require Borrower to assemble the Collateral and make it available to Agent at a place designated by Agent that is reasonably convenient to Agent and Borrower. The proceeds of
any sale, disposition or other realization upon all or any part of the Collateral shall be applied by Agent in the following order of priorities: 

First, to Agent and the Lenders in an amount sufficient to pay in full Agent’s and the Lenders’ reasonable and documented out-of-pocket costs and professionals’ and advisors’ fees and expenses as described in Section 11.12; 

Second, to the Lenders in an amount equal to the then unpaid amount of the Secured Obligations (including principal, interest, and any default
rate interest), in such order and priority as Agent may choose in its sole discretion; and 
 Finally, after the full and final payment in
Cash of all of the Secured Obligations (other than inchoate obligations), to any creditor holding a junior Lien on the Collateral, or to Borrower or its representatives or as a court of competent jurisdiction may direct. 

Agent shall be deemed to have acted reasonably in the custody, preservation and disposition of any of the Collateral if it complies with the obligations of a
secured party under the UCC. 
 10.3 No Waiver. Agent shall be under no obligation to marshal any of the Collateral for the
benefit of Borrower or any other Person, and Borrower expressly waives all rights, if any, to require Agent to marshal any Collateral. 

10.4 Cumulative Remedies. The rights, powers and remedies of Agent hereunder shall be in addition to all rights, powers and
remedies given by statute or rule of law and are cumulative. The exercise of any one or more of the rights, powers and remedies provided herein shall not be construed as a waiver of or election of remedies with respect to any other rights, powers
and remedies of Agent. 
 SECTION 11. MISCELLANEOUS 

11.1 Severability. Whenever possible, each provision of this Agreement shall be interpreted in such manner as to be effective
and valid under applicable law, but if any provision of this Agreement shall be prohibited by or invalid under such law, such provision shall be ineffective only to the extent and duration of such prohibition or invalidity, without invalidating the
remainder of such provision or the remaining provisions of this Agreement. 











 11.2 Notice. Except as otherwise provided herein, any notice, demand,
request, consent, approval, declaration, service of process or other communication (including the delivery of Financial Statements) that is required, contemplated, or permitted under the Loan Documents or with respect to the subject matter hereof
shall be in writing, and shall be deemed to have been validly served, given, delivered, and received upon the earlier of: (i) the day of transmission by electronic mail or hand delivery or delivery by an overnight express service or overnight
mail delivery service; or (ii) the third calendar day after deposit in the United States of America mails, with proper first class postage prepaid, in each case addressed to the party to be notified as follows: 

 

	 	(a)	 If to Agent: 



HERCULES CAPITAL, INC. 
 Legal
Department 
 Attention: Chief Legal Officer and Lake Thomas McGuire 

400 Hamilton Avenue, Suite 310 

Palo Alto, CA 94301 
 email:
legal@htgc.com 
 Telephone: 650-289-3060 

 

	 	(b)	 If to the Lenders: 



HERCULES TECHNOLOGY III, L.P. 

Legal Department 
 Attention:
Chief Legal Officer and Lake Thomas McGuire 
 400 Hamilton Avenue, Suite 310 

Palo Alto, CA 94301 
 email:
legal@htgc.com 
 Telephone: 650-289-3060 

 

	 	(c)	 If to Borrower: 



Kura Oncology, Inc. 
 Attention:
Tom Doyle 
 12730 High Bluff Drive, Suite 400 

San Diego, CA 92130 
 email:

 Telephone: 
 with a copy
to: 
 Kura Oncology, Inc. 

Attention: Teresa Bair 
 12730
High Bluff Drive, Suite 400 
 San Diego, CA 92130 

email: 
 Telephone: 

with a copy to: 
 Cooley LLP

 Attention: Charles Bair 











 10265 Science Center Drive 

San Diego, CA 92121-1117 

email: 
 Telephone: 

or to such other address as each party may designate for itself by giving notice in conformity with this Section 11.2. 

11.3 Entire Agreement; Amendments. 

(a) This Agreement and the other Loan Documents constitute the entire agreement and understanding of the parties hereto in
respect of the subject matter hereof and thereof, and supersede and replace in their entirety any prior proposals, term sheets, non-disclosure or confidentiality agreements, letters, negotiations or other
documents or agreements, whether written or oral, with respect to the subject matter hereof or thereof (including Agent’s revised proposal letter dated October 13, 2022). 

(b) Neither this Agreement, any other Loan Document, nor any terms hereof or thereof may be amended, supplemented or modified
except in accordance with the provisions of this Section 11.3(b). The Required Lenders and Borrower party to the relevant Loan Document may, or, with the written consent of the Required Lenders, the Agent and Borrower party to the relevant Loan
Document may, from time to time, (i) enter into written amendments, supplements or modifications hereto and to the other Loan Documents for the purpose of adding any provisions to this Agreement or the other Loan Documents or changing in any
manner the rights of the Lenders or of Borrower hereunder or thereunder or (ii) waive, on such terms and conditions as the Required Lenders or the Agent, as the case may be, may specify in such instrument, any of the requirements of this
Agreement or the other Loan Documents or any default or Event of Default and its consequences; provided, however, that no such waiver and no such amendment, supplement or modification shall (A) forgive the principal amount or extend the final
scheduled date of maturity of any Loan, extend the scheduled date of any amortization payment in respect of any Term Loan, reduce the stated rate of any interest (or fee payable hereunder) or extend the scheduled date of any payment thereof, in each
case without the written consent of each Lender directly affected thereby; (B) eliminate or reduce the voting rights of any Lender under this Section 11.3(b) without the written consent of such Lender; (C) reduce any percentage
specified in the definition of Required Lenders, consent to the assignment or transfer by Borrower of any of its rights and obligations under this Agreement and the other Loan Documents, release all or substantially all of the Collateral or release
a Borrower from its obligations under the Loan Documents, in each case without the written consent of all Lenders; or (D) amend, modify or waive any provision of Section 11.18 or Addendum 3 without the written consent of the Agent. Any
such waiver and any such amendment, supplement or modification shall apply equally to each Lender and shall be binding upon Borrower, the Lender, the Agent and all future holders of the Loans. 

11.4 No Strict Construction. The parties hereto have participated jointly in the negotiation and drafting of this Agreement. In
the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of the
authorship of any provisions of this Agreement. 
 11.5 No Waiver. The powers conferred upon Agent and the Lenders by this
Agreement are solely to protect its rights hereunder and under the other Loan Documents and its interest in the Collateral and shall not impose any duty upon Agent or the Lenders to exercise any such powers.












 
No omission or delay by Agent or the Lenders at any time to enforce any right or remedy reserved to it, or to require performance of any of the terms, covenants or provisions hereof by Borrower
at any time designated, shall be a waiver of any such right or remedy to which Agent or the Lenders is entitled, nor shall it in any way affect the right of Agent or the Lenders to enforce such provisions thereafter. 

11.6 Survival. All agreements, representations and warranties contained in this Agreement and the other Loan Documents or in
any document delivered pursuant hereto or thereto shall be for the benefit of Agent and the Lenders and shall survive the execution and delivery of this Agreement for so long as any Secured Obligations (other than any inchoate indemnity or
reimbursement obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) remain outstanding. Sections 6.3, 11.13, 11.14, 11.15 and 11.17 shall survive the termination of this Agreement. 

11.7 Successors and Assigns. The provisions of this Agreement and the other Loan Documents shall inure to the benefit of and be
binding on Borrower and its permitted assigns (if any). Borrower shall not assign its obligations under this Agreement or any of the other Loan Documents without Agent’s express prior written consent, and any such attempted assignment shall be
void and of no effect. Agent and the Lenders may assign, transfer, or endorse its rights hereunder and under the other Loan Documents with prior notice to Borrower (except if an Event of Default has occurred and is continuing or such assignment is
to an Affiliate of Lender or Agent, in which case no notice shall be required), and all of such rights shall inure to the benefit of Agent’s and the Lenders’ successors and assigns; provided that as long as no Event of Default has occurred
and is continuing, neither Agent nor any Lender may assign, transfer or endorse its rights hereunder or under the Loan Documents to any party that is a direct competitor of Borrower (as reasonably determined by Agent upon consultation with Borrower)
or any investment fund specializing in distressed debt, it being acknowledged that in all cases, any transfer to an Affiliate of any Lender or Agent shall be allowed. Notwithstanding the foregoing, (x) in connection with any assignment by a
Lender as a result of a forced divestiture at the request of any regulatory agency, the restrictions set forth herein shall not apply and Agent and the Lenders may assign, transfer or indorse its rights hereunder and under the other Loan Documents
to any Person or party and (y) in connection with a Lender’s own financing or securitization transactions, the restrictions set forth herein shall not apply and Agent and the Lenders may assign, transfer or indorse its rights hereunder and
under the other Loan Documents to any Person or party providing such financing or formed to undertake such securitization transaction and any transferee of such Person or party upon the occurrence of a default, event of default or similar occurrence
with respect to such financing or securitization transaction; provided that no such sale, transfer, pledge or assignment under this clause (y) shall release such Lender from any of its obligations hereunder or substitute any such Person or
party for such Lender as a party hereto until Agent shall have received and accepted an effective assignment agreement from such Person or party in form satisfactory to Agent executed, delivered and fully completed by the applicable parties thereto,
and shall have received such other information regarding such assignee as Agent reasonably shall require. The Agent, acting solely for this purpose as an agent of Borrower, shall maintain at one of its offices in the United States a register for the
recordation of the names and addresses of the Lender(s), and the Term Commitments of, and principal amounts (and stated interest) of the Loans owing to, each Lender pursuant to the terms hereof from time to time (the “Register”). The
entries in the Register shall be conclusive absent manifest error, and Borrower, the Agent and the Lender(s) shall treat each Person whose name is recorded in the Register pursuant to the terms hereof as a Lender hereunder for all purposes of this
Agreement. The Register shall be available for inspection by Borrower and any Lender, at any reasonable time and from time to time upon reasonable prior notice. 











 11.8 Participations. Each Lender that sells a participation shall, acting
solely for this purpose as a non-fiduciary agent of the Borrower, maintain a register on which it enters the name and address of each participant and the principal amounts (and stated interest) of each
participant’s interest in the Loans or other obligations under the Loan Documents (the “Participant Register”); provided that no Lender shall have any obligation to disclose all or any portion of the Participant Register (including
the identity of any participant or any information relating to a participant’s interest in any commitments, loans, its other obligations under any Loan Document) to any Person except to the extent that such disclosure is necessary to establish
that such commitment, loan, letter of credit or other obligation is in registered form under Section 5f.103-1(c) of the United States Treasury Regulations. The entries in the Participant Register shall be
conclusive absent manifest error, and such Lender shall treat each Person whose name is recorded in the Participant Register as the owner of such participation for all purposes of this Agreement notwithstanding any notice to the contrary. For the
avoidance of doubt, the Agent (in its capacity as Agent) shall have no responsibility for maintaining a Participant Register. Borrower agrees that each participant shall be entitled to the benefits of the provisions in Addendum 1 attached hereto
(subject to the requirements and limitations therein, including the requirements under Section 7 of Addendum 1 attached hereto (it being understood that the documentation required under Section 7 of Addendum 1 attached hereto shall be
delivered to the participating Lender)) to the same extent as if it were a Lender and had acquired its interest by assignment pursuant to Section 11.7; provided that such participant shall not be entitled to receive any greater payment under
Addendum 1 attached hereto, with respect to any participation, than its participating Lender would have been entitled to receive, except to the extent such entitlement to receive a greater payment results from a change in law that occurs after the
participant acquired the applicable participation. 
 11.9 Governing Law. This Agreement and the other Loan Documents have
been negotiated and delivered to Agent and the Lenders in the State of California, and shall have been accepted by Agent and the Lenders in the State of California. Payment to Agent and the Lenders by Borrower of the Secured Obligations is due in
the State of California. This Agreement and the other Loan Documents shall be governed by, and construed and enforced in accordance with, the laws of the State of California, excluding conflict of laws principles that would cause the application of
laws of any other jurisdiction. 
 11.10 Consent to Jurisdiction and Venue. All judicial proceedings (to the extent that the
reference requirement of Section 11.11 is not applicable) arising in or under or related to this Agreement or any of the other Loan Documents may be brought in any state or federal court located in the State of California. By execution and
delivery of this Agreement, each party hereto generally and unconditionally: (a) consents to nonexclusive personal jurisdiction in Santa Clara County, State of California; (b) waives any objection as to jurisdiction or venue in Santa Clara
County, State of California; (c) agrees not to assert any defense based on lack of jurisdiction or venue in the aforesaid courts; and (d) irrevocably agrees to be bound by any judgment rendered thereby in connection with this Agreement or
the other Loan Documents. Service of process on any party hereto in any action arising out of or relating to this Agreement shall be effective if given in accordance with the requirements for notice set forth in Section 11.2, and shall be
deemed effective and received as set forth in Section 11.2. Nothing herein shall affect the right to serve process in any other manner permitted by law or shall limit the right of either party to bring proceedings in the courts of any other
jurisdiction. 
 11.11 Mutual Waiver of Jury Trial / Judicial Reference. 

(a) Because disputes arising in connection with complex financial transactions are most quickly and economically resolved by an
experienced and expert Person and the parties wish 











 
applicable state and federal laws to apply (rather than arbitration rules), the parties desire that their disputes be resolved by a judge applying such applicable laws. EACH OF BORROWER, AGENT
AND THE LENDERS SPECIFICALLY WAIVES ANY RIGHT IT MAY HAVE TO TRIAL BY JURY OF ANY CAUSE OF ACTION, CLAIM, CROSS-CLAIM, COUNTERCLAIM, THIRD PARTY CLAIM OR ANY OTHER CLAIM (COLLECTIVELY, “CLAIMS”) ASSERTED BY BORROWER AGAINST AGENT, THE
LENDERS OR THEIR RESPECTIVE ASSIGNEE OR BY AGENT, THE LENDERS OR THEIR RESPECTIVE ASSIGNEE AGAINST BORROWER. This waiver extends to all such Claims, including Claims that involve Persons other than Agent, Borrower and the Lenders; Claims that arise
out of or are in any way connected to the relationship among Borrower, Agent and the Lenders; and any Claims for damages, breach of contract, tort, specific performance, or any equitable or legal relief of any kind, arising out of this Agreement,
any other Loan Document. 
 (b) If the waiver of jury trial set forth in Section 11.11(a) is ineffective or
unenforceable, the parties agree that all Claims shall be resolved by reference to a private judge sitting without a jury, pursuant to Code of Civil Procedure Section 638, before a mutually acceptable referee or, if the parties cannot agree, a
referee selected by the Presiding Judge of the Santa Clara County, California. Such proceeding shall be conducted in Santa Clara County, California, with California rules of evidence and discovery applicable to such proceeding. 

(c) In the event Claims are to be resolved by judicial reference, either party may seek from a court identified in
Section 11.10, any prejudgment order, writ or other relief and have such prejudgment order, writ or other relief enforced to the fullest extent permitted by law notwithstanding that all Claims are otherwise subject to resolution by judicial
reference. 
 11.12 Professional Fees. Borrower promises to pay Agent’s and the Lenders’ reasonable and documented out-of-pocket fees and expenses necessary to finalize the Loan Documents, including but not limited to reasonable and documented out-of-pocket attorneys’ fees, UCC searches, filing costs, and other miscellaneous expenses; provided that that the amount of such costs and expenses obligated to be paid by Borrower shall not exceed
$250,000; provided, further that the Due Diligence Fee will be applied in its entirety toward such fees and expenses. In addition, Borrower promises to pay any and all reasonable and documented out-of-pocket attorneys’ and other professionals’ fees and expenses incurred by Agent and the Lenders after the Closing Date in connection with or related to: (a) the Loan; (b) the
administration, collection, or enforcement of the Loan; (c) the amendment or modification of the Loan Documents; (d) any waiver, consent, release, or termination under the Loan Documents; (e) the protection, preservation, audit, field
exam, sale, lease, liquidation, or disposition of Collateral or the exercise of remedies with respect to the Collateral; (f) any legal, litigation, administrative, arbitration, or out of court proceeding in connection with or related to
Borrower or the Collateral, and any appeal or review thereof; and (g) any bankruptcy, restructuring, reorganization, assignment for the benefit of creditors, workout, foreclosure, or other action related to Borrower, the Collateral, the Loan
Documents, including representing Agent or the Lenders in any adversary proceeding or contested matter commenced or continued by or on behalf of Borrower’s estate, and any appeal or review thereof. 

11.13 Confidentiality. Agent and the Lenders acknowledge that certain items of Collateral and information provided to Agent and
the Lenders by Borrower are confidential and proprietary information of Borrower, if and to the extent such information either (x) is marked as confidential by Borrower at the time of disclosure, or (y) should reasonably be understood to
be confidential (the “Confidential Information”). Accordingly, Agent and the Lenders agree that any Confidential Information it may obtain in the course of acquiring, administering, or perfecting Agent’s security interest in the
Collateral shall not be disclosed to any other Person or entity in any manner 











 
whatsoever, in whole or in part, without the prior written consent of Borrower, except that Agent and the Lenders may disclose any such information: (a) to its Affiliates and its partners,
investors, lenders, directors, officers, employees, agents, advisors, counsel, accountants, representative and other professional advisors if Agent or the Lenders in their sole discretion determines that any such party should have access to such
information in connection with such party’s responsibilities in connection with the Loan or this Agreement and, provided that such recipient of such Confidential Information either (i) agrees to be bound by the confidentiality provisions
of this paragraph or (ii) is otherwise subject to confidentiality restrictions that reasonably protect against the disclosure of Confidential Information which are no less restrictive than the terms of this Section 11.13; (b) if such
information is generally available to the public or to the extent such information becomes publicly available other than as a result of a breach of this Section or becomes available to Agent or any Lender, or any of their respective Affiliates on a non-confidential basis from a source other than Borrower; (c) if required or appropriate in any report, statement or testimony submitted to any governmental authority having or claiming to have jurisdiction
over Agent or the Lenders and any rating agency; (d) if required or appropriate in response to any summons or subpoena or in connection with any litigation, to the extent permitted or deemed advisable by Agent’s or the Lenders’
counsel; (e) to comply with any legal requirement or law applicable to Agent or the Lenders or demanded by any governmental authority; (f) to the extent reasonably necessary in connection with the exercise of, or preparing to exercise, or
the enforcement of, or preparing to enforce, any right or remedy under any Loan Document (including Agent’s sale, lease, or other disposition of Collateral after the occurrence and during the continuance of an Event of Default), or any action
or proceeding relating to any Loan Document; (g) to any participant or assignee of Agent or the Lenders or any prospective participant or assignee, provided, that such participant or assignee or prospective participant or assignee is subject to
confidentiality restrictions that reasonably protect against the disclosure of Confidential Information which are no less restrictive than the terms of this Section 11.13; (h) otherwise to the extent consisting of general portfolio information
that does not identify Borrower; or (i) otherwise with the prior written consent of Borrower; provided, that any disclosure made in violation of this Agreement shall not affect the obligations of Borrower or any of its Affiliates or any
guarantor under this Agreement or the other Loan Documents. Agent’s and the Lenders’ obligations under this Section 11.13 shall supersede all of their respective obligations under the
Non-Disclosure Agreement. 
 11.14 Assignment of Rights. Borrower acknowledges and
understands that Agent or the Lenders may, subject to Section 11.7, sell and assign all or part of its interest hereunder and under the Loan Documents to any Person or entity (an “Assignee”). After such assignment the term
“Agent” or “Lender” as used in the Loan Documents shall mean and include such Assignee, and such Assignee shall be vested with all rights, powers and remedies of Agent and the Lenders hereunder with respect to the interest so
assigned; but with respect to any such interest not so transferred, Agent and the Lenders shall retain all rights, powers and remedies hereby given. No such assignment by Agent or the Lenders shall relieve Borrower of any of its obligations
hereunder. the Lenders agrees that in the event of any transfer by it of the promissory note(s) (if any), it will endorse thereon a notation as to the portion of the principal of the promissory note(s), which shall have been paid at the time of such
transfer and as to the date to which interest shall have been last paid thereon. 
 11.15 Revival of Secured Obligations.
This Agreement and the Loan Documents shall remain in full force and effect and continue to be effective if any petition is filed by or against Borrower for liquidation or reorganization, if Borrower becomes insolvent or makes an assignment for the
benefit of creditors, if a receiver or trustee is appointed for all or any significant part of Borrower’s assets, or if any payment or transfer of Collateral is recovered from Agent or the Lenders. The Loan Documents and the Secured Obligations
and Collateral security shall continue to be 











 
effective, or shall be revived or reinstated, as the case may be, if at any time payment and performance of the Secured Obligations or any transfer of Collateral to Agent, or any part thereof is
rescinded, avoided or avoidable, reduced in amount, or must otherwise be restored or returned by, or is recovered from, Agent, the Lenders or by any obligee of the Secured Obligations, whether as a “voidable preference,” “fraudulent
conveyance,” or otherwise, all as though such payment, performance, or transfer of Collateral had not been made. In the event that any payment, or any part thereof, is rescinded, reduced, avoided, avoidable, restored, returned, or recovered,
the Loan Documents and the Secured Obligations shall be deemed, without any further action or documentation, to have been revived and reinstated except to the extent of the full, final, and indefeasible payment to Agent or the Lenders in Cash. 

11.16 Counterparts. This Agreement and any amendments, waivers, consents or supplements hereto may be executed in any number of
counterparts, and by different parties hereto in separate counterparts, each of which when so delivered shall be deemed an original, but all of which counterparts shall constitute but one and the same instrument. 

11.17 No Third Party Beneficiaries. No provisions of the Loan Documents are intended, nor will be interpreted, to provide or
create any third-party beneficiary rights or any other rights of any kind in any Person other than Agent, the Lenders and Borrower unless specifically provided otherwise herein, and, except as otherwise so provided, all provisions of the Loan
Documents will be personal and solely among Agent, the Lenders and Borrower. 
 11.18 Agency. Agent and each Lender hereby
agree to the terms and conditions set forth on Addendum 3 attached hereto. Borrower acknowledges and agrees to the terms and conditions set forth on Addendum 3 attached hereto. 

11.19 Publicity. None of the parties hereto nor any of its respective member businesses and Affiliates shall, without the other
parties’ prior written consent (which shall not be unreasonably withheld or delayed), publicize or use (a) the other party’s name (including a brief description of the relationship among the parties hereto), logo or hyperlink to such
other parties’ web site, separately or together, in written and oral presentations, advertising, promotional and marketing materials, client lists, public relations materials or on its web site (together, the “Publicity Materials”);
(b) the names of officers of such other parties in the Publicity Materials; and (c) such other parties’ name, trademarks, servicemarks in any news or press release concerning such party; provided however, notwithstanding anything to the
contrary herein, no such consent shall be required (i) to the extent necessary to comply with the requests of any regulators, legal requirements or laws applicable to such party, pursuant to any listing agreement with any national securities
exchange (so long as such party provides prior notice to the other party hereto to the extent reasonably practicable) and (ii) to comply with Section 11.13. 

11.20 Electronic Execution of Certain Other Documents. The words “execution,” “execute”,
“signed,” “signature,” and words of like import in or related to any document to be signed in connection with this Agreement and the transactions contemplated hereby (including without limitation assignments, assumptions,
amendments, waivers and consents) shall be deemed to include electronic signatures, the electronic matching of assignment terms and contract formations on electronic platforms approved by the Agent, or the keeping of records in electronic form, each
of which shall be of the same legal effect, validity or enforceability as a manually executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the
Federal Electronic Signatures in Global and National Commerce Act, the California Uniform Electronic Transaction Act, or any other similar state laws based on the Uniform Electronic Transactions Act. 











 (SIGNATURES TO FOLLOW) 











 IN WITNESS WHEREOF, Borrower, Agent and the Lender have duly executed and delivered this
Loan and Security Agreement as of the day and year first above written. 
  

			
	BORROWER:
	
	KURA ONCOLOGY, INC.
		
	Signature:	 	/s/ Troy Wilson
	Print Name:	 	Troy Wilson
	Title:	 	President and Chief Executive Officer


 Accepted in Palo Alto, California: 

 

			
		
	AGENT:	 	
	
	HERCULES CAPITAL, INC.
		
	Signature:	 	/s/ Seth Meyer
	Print Name:	 	Seth Meyer
	Title:	 	Chief Financial Officer


  

			
	LENDER:
	
	HERCULES CAPITAL IV, L.P.,
		
	By:	 	Hercules Technology SBIC
		 	Management, LLC, its General Partner
	By:	 	Hercules Capital, Inc., its Manager


  

			
	Signature:	 	/s/ Seth Meyer
	Print Name:	 	Seth Meyer
	Title:	 	Chief Financial Officer


  

  
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and Security Agreement 












 
			
	LENDER:
	
	HERCULES PRIVATE CREDIT FUND 1 L.P.


 
			
		
	By:	 	Hercules Adviser LLC, its Investment Adviser


 
			
		
	Signature:	 	/s/ Seth Meyer
	Print Name:	 	Seth Meyer
	Title:	 	Chief Financial Officer


  

			
	LENDER:
	
	HERCULES PRIVATE GLOBAL VENTURE GROWTH FUND I L.P.


 
			
		
	By:	 	Hercules Adviser LLC, its Investment Adviser


 
			
		
	Signature:	 	/s/ Seth Meyer
	Print Name:	 	Seth Meyer
	Title:	 	Chief Financial Officer


  

  
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and Security Agreement 












 TABLE OF EXHIBITS AND SCHEDULES 

 

			
	Addendum 1:	  	Taxes; Increased Costs
		
	Addendum 2:	  	SBIC
		
	Addendum 3:	  	Agent and Lender Terms
		
	Exhibit A:	  	 Advance Request
 Attachment to Advance
Request

		
	Exhibit B:	  	[Reserved.]
		
	Exhibit C:	  	[Reserved.]
		
	Exhibit D:	  	[Reserved.]
		
	Exhibit E:	  	Compliance Certificate
		
	Exhibit F:	  	Joinder Agreement
		
	Exhibit G:	  	[Reserved.]
		
	Exhibit H:	  	ACH Debit Authorization Agreement
		
	Exhibit I:	  	[Reserved.]
		
	Exhibit J-1:	  	Form of U.S. Tax Compliance Certificate (For Foreign Lenders That Are Not Partnerships For U.S. Federal Income Tax Purposes)
		
	Exhibit J-2:	  	Form of U.S. Tax Compliance Certificate (For Foreign Participants That Are Not Partnerships For U.S. Federal Income Tax Purposes)
		
	Exhibit J-3:	  	Form of U.S. Tax Compliance Certificate (For Foreign Participants That Are Partnerships For U.S. Federal Income Tax Purposes)
		
	Exhibit J-4:	  	Form of U.S. Tax Compliance Certificate (For Foreign Lenders That Are Partnerships For U.S. Federal Income Tax Purposes)
		
	Schedule 1.1	  	Commitments












 ADDENDUM 1 to LOAN AND SECURITY AGREEMENT 

TAXES; INCREASED COSTS 
  

	1.	 Defined Terms. For purposes of this Addendum 1: 



 

	 	a.	 “Connection Income Taxes” means Other Connection Taxes that are imposed on or measured by net
income (however denominated) or that are franchise Taxes or branch profits Taxes. 


  

	 	b.	 “Excluded Taxes” means any of the following Taxes imposed on or with respect to a Recipient or
required to be withheld or deducted from a payment to a Recipient, (i) Taxes imposed on or measured by net income (however denominated), franchise Taxes, and branch profits Taxes, in each case, (A) imposed as a result of such Recipient
being organized under the laws of, or having its principal office or, in the case of any Lender, its applicable lending office located in, the jurisdiction imposing such Tax (or any political subdivision thereof) or (B) that are Other
Connection Taxes, (ii) in the case of a Lender, U.S. federal withholding Taxes imposed on amounts payable to or for the account of such Lender with respect to an applicable interest in a Loan or Term Commitment pursuant to a law in effect on
the date on which (A) such Lender acquires such interest in the Loan or Term Commitment or (B) such Lender changes its lending office, except in each case to the extent that, pursuant to Section 2 or Section 4 of this Addendum 1,
amounts with respect to such Taxes were payable either to such Lender’s assignor immediately before such Lender became a party hereto or to such Lender immediately before it changed its lending office, (iii) Taxes attributable to such
Recipient’s failure to comply with Section 7 of this Addendum 1 and (iv) any withholding Taxes imposed under FATCA. 


  

	 	c.	 “FATCA” means Sections 1471 through 1474 of the Code, as of the date of this Agreement (or any
amended or successor version that is substantively comparable and not materially more onerous to comply with), any current or future regulations or official interpretations thereof, any agreements entered into pursuant to Section 1471(b)(1) of
the Code, and any fiscal or regulatory legislation, rules or practices adopted pursuant to any intergovernmental agreement, treaty or convention among governmental authorities and implementing such Sections of the Code. 



 

	 	d.	 “Foreign Lender” means a Lender that is not a U.S. Person. 



 

	 	e.	 “Indemnified Taxes” means (i) Taxes, other than Excluded Taxes, imposed on or with
respect to any payment made by or on account of any obligation of Borrower under any Loan Document and (ii) to the extent not otherwise described in clause (i), Other Taxes. 



 

	 	f.	 “Other Connection Taxes” means, with respect to any Recipient, Taxes imposed as a result of a
present or former connection between such Recipient and the jurisdiction imposing such Tax (other than connections arising from such Recipient having executed, delivered, become a party to, performed its obligations under, received payments under,
received or perfected a security interest under, engaged in any other transaction pursuant to or enforced any Loan Document, or sold or assigned an interest in any Loan or Loan Document). 



 

	 	g.	 “Other Taxes” means all present or future stamp, court or documentary, intangible, recording,
filing or similar Taxes that arise from any payment made under, from the execution, delivery, performance, enforcement or registration of, from the receipt or perfection of a security interest under, or otherwise with respect to, any Loan Document,
except any such Taxes that are Other Connection Taxes imposed with respect to an assignment. 



  
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	 	h.	 “Recipient” means the Agent or any Lender, as applicable. 



 

	 	i.	 “Withholding Agent” means Borrower and the Agent. 



 

	2.	 Payments Free of Taxes. Any and all payments by or on account of any obligation of Borrower under any
Loan Document shall be made without deduction or withholding for any Taxes, except as required by applicable law. If any applicable law (as determined in the good faith discretion of an applicable Withholding Agent) requires the deduction or
withholding of any Tax from any such payment by a Withholding Agent, then the applicable Withholding Agent shall be entitled to make such deduction or withholding and shall timely pay the full amount deducted or withheld to the relevant governmental
authority in accordance with applicable law and, if such Tax is an Indemnified Tax, then the sum payable by Borrower shall be increased as necessary so that after such deduction or withholding has been made (including such deductions and
withholdings applicable to additional sums payable under this Section 2 or Section 4 of this Addendum 1) the applicable Recipient receives an amount equal to the sum it would have received had no such deduction or withholding been made.



  

	3.	 Payment of Other Taxes by Borrower. Borrower shall timely pay to the relevant governmental authority in
accordance with applicable law, or at the option of the Agent timely reimburse it for the payment of, any Other Taxes. 


  

	4.	 Indemnification by Borrower. Borrower shall indemnify each Recipient, within 10 days after demand
therefor, for the full amount of any Indemnified Taxes (including Indemnified Taxes imposed or asserted on or attributable to amounts payable under Section 2 of this Addendum 1 or this Section 4) payable or paid by such Recipient or
required to be withheld or deducted from a payment to such Recipient and any reasonable expenses arising therefrom or with respect thereto, whether or not such Indemnified Taxes were correctly or legally imposed or asserted by the relevant
governmental authority. A certificate as to the amount of such payment or liability delivered to Borrower by a Lender (with a copy to the Agent), or by the Agent on its own behalf or on behalf of a Lender, shall be conclusive absent manifest error.
In addition, Borrower agrees to pay, and to save the Agent and any Lender harmless from, any and all liabilities with respect to, or resulting from any delay in paying, any and all excise, sales or other similar taxes (excluding taxes imposed on or
measured by the net income of the Agent or such Lender) that may be payable or determined to be payable with respect to any of the Collateral. 


  

	5.	 Indemnification by the Lenders. Each Lender shall severally indemnify the Agent, within 10 days after
demand therefor, for (a) any Indemnified Taxes attributable to such Lender (but only to the extent that Borrower has not already indemnified the Agent for such Indemnified Taxes and without limiting the obligation of Borrower to do so), (b) any
Taxes attributable to such Lender’s failure to comply with the provisions of Section 11.8 of the Agreement relating to the maintenance of a Participant Register, and (c) any Excluded Taxes attributable to such Lender, in each case,
that are payable or paid by the Agent in connection with any Loan Document, and any reasonable expenses arising therefrom or with respect thereto, whether or not such Taxes were correctly or legally imposed or asserted by the relevant governmental
authority. A certificate as to the amount of such payment or liability delivered to any Lender by the Agent shall be conclusive absent manifest error. Each Lender hereby authorizes the Agent to set off and apply any and all amounts at any time owing
to such Lender under any Loan Document or otherwise payable by the Agent to the Lender from any other source against any amount due to the Agent under this Section 5. 



 

	6.	 Evidence of Payments. As soon as practicable after any payment of Taxes by Borrower to a governmental
authority pursuant to the provisions of this Addendum 1, Borrower shall deliver to the 



  
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Agent the original or a certified copy of a receipt issued by such governmental authority evidencing such payment, a copy of the return reporting such payment or other evidence of such payment
reasonably satisfactory to the Agent. 

  

	7.	 Status of Lenders. 



 

	 	a.	 Any Lender that is entitled to an exemption from or reduction of withholding Tax with respect to payments made
under any Loan Document shall deliver to Borrower and the Agent, at the time or times reasonably requested by Borrower or the Agent, such properly completed and executed documentation reasonably requested by Borrower or the Agent as will permit such
payments to be made without withholding or at a reduced rate of withholding. In addition, any Lender, if reasonably requested by Borrower or the Agent, shall deliver such other documentation prescribed by applicable law or reasonably requested by
Borrower or the Agent as will enable Borrower or the Agent to determine whether or not such Lender is subject to backup withholding or information reporting requirements. Notwithstanding anything to the contrary in the preceding two sentences, the
completion, execution and submission of such documentation (other than such documentation set forth in Sections 7(b)(i), 7(b)(ii) and 7(b)(iv) of this Addendum 1) shall not be required if in the Lender’s reasonable judgment such completion,
execution or submission would subject such Lender to any material unreimbursed cost or expense or would materially prejudice the legal or commercial position of such Lender. 



 

	 	b.	 Without limiting the generality of the foregoing, in the event that Borrower is a U.S. Person,



  

	 	i.	 any Lender that is a U.S. Person shall deliver to Borrower and the Agent on or prior to the date on which such
Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of Borrower or the Agent), executed copies of IRS Form W-9 certifying that such Lender is exempt from
U.S. federal backup withholding tax; 


  

	 	ii.	 any Foreign Lender shall, to the extent it is legally entitled to do so, deliver to Borrower and the Agent (in
such number of copies as shall be requested by the recipient) on or prior to the date on which such Foreign Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of Borrower or the Agent),
whichever of the following is applicable: 


  

	 	A.	 in the case of a Foreign Lender claiming the benefits of an income tax treaty to which the United States is a
party (x) with respect to payments of interest under any Loan Document, executed copies of IRS Form W-8BEN or IRS Form
W-8BEN-E establishing an exemption from, or reduction of, U.S. federal withholding Tax pursuant to the “interest” article of such tax treaty and (y) with
respect to any other applicable payments under any Loan Document, IRS Form W-8BEN or IRS Form W-8BEN-E establishing an exemption
from, or reduction of, U.S. federal withholding Tax pursuant to the “business profits” or “other income” article of such tax treaty; 


  

	 	B.	 executed copies of IRS Form W-8ECI; 



 

	 	C.	 in the case of a Foreign Lender claiming the benefits of the exemption for portfolio interest under
Section 881(c) of the Code, (x) a certificate substantially in the form of Exhibit J-1 to the effect that such Foreign Lender is not a “bank” within the meaning of Section 881(c)(3)(A)
of the Code, a “10 



  
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percent shareholder” of Borrower within the meaning of Section 871(h)(3)(B) of the Code, or a “controlled foreign corporation” related to Borrower as described in
Section 881(c)(3)(C) of the Code (a “U.S. Tax Compliance Certificate”) and (y) executed copies of IRS Form W-8BEN or IRS Form W-8BEN-E; or 

  

	 	D.	 to the extent a Foreign Lender is not the beneficial owner, executed copies of IRS Form W-8IMY, accompanied by IRS Form W-8ECI, IRS Form W-8BEN, IRS Form
W-8BEN-E, a U.S. Tax Compliance Certificate substantially in the form of Exhibit J-2 or Exhibit
J-3, IRS Form W-9, and/or other certification documents from each beneficial owner, as applicable; provided that if the Foreign Lender is a partnership and one or more
direct or indirect partners of such Foreign Lender are claiming the portfolio interest exemption, such Foreign Lender may provide a U.S. Tax Compliance Certificate substantially in the form of Exhibit J-4 on
behalf of each such direct and indirect partner; 


  

	 	iii.	 any Foreign Lender shall, to the extent it is legally entitled to do so, deliver to Borrower and the Agent (in
such number of copies as shall be requested by the recipient) on or prior to the date on which such Foreign Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of Borrower or the Agent),
executed copies of any other form prescribed by applicable law as a basis for claiming exemption from or a reduction in U.S. federal withholding Tax, duly completed, together with such supplementary documentation as may be prescribed by applicable
law to permit Borrower or the Agent to determine the withholding or deduction required to be made; and 


  

	 	iv.	 if a payment made to a Lender under any Loan Document would be subject to U.S. federal withholding Tax imposed
by FATCA if such Lender were to fail to comply with the applicable reporting requirements of FATCA (including those contained in Section 1471(b) or 1472(b) of the Code, as applicable), such Lender shall deliver to Borrower and the Agent at the
time or times prescribed by law and at such time or times reasonably requested by Borrower or the Agent such documentation prescribed by applicable law (including as prescribed by Section 1471(b)(3)(C)(i) of the Code) and such additional
documentation reasonably requested by Borrower or the Agent as may be necessary for Borrower and the Agent to comply with their obligations under FATCA and to determine that such Lender has complied with such Lender’s obligations under FATCA or
to determine the amount, if any, to deduct and withhold from such payment. Solely for purposes of this clause (iv), “FATCA” shall include any amendments made to FATCA after the date of this Agreement. 



 

	 	c.	 Each Lender agrees that if any form or certification it previously delivered expires or becomes obsolete or
inaccurate in any respect, it shall update such form or certification or promptly notify Borrower and the Agent in writing of its legal inability to do so. 


  

	8.	 Treatment of Certain Refunds. If any party determines, in its sole discretion exercised in good faith,
that it has received a refund of any Taxes as to which it has been indemnified pursuant to the provisions of this Addendum 1 (including by the payment of additional amounts pursuant to the provisions of this Addendum 1), it shall pay to the
indemnifying party an amount equal to such refund (but only to the extent of indemnity payments made under the provisions of this Addendum 1 with respect to the Taxes 



  
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giving rise to such refund), net of all out-of-pocket expenses (including Taxes) of such indemnified party and
without interest (other than any interest paid by the relevant governmental authority with respect to such refund). Such indemnifying party, upon the request of such indemnified party, shall repay to such indemnified party the amount paid over
pursuant to this Section 8 (plus any penalties, interest or other charges imposed by the relevant governmental authority) in the event that such indemnified party is required to repay such refund to such governmental authority. Notwithstanding
anything to the contrary in this Section 8, in no event will the indemnified party be required to pay any amount to an indemnifying party pursuant to this Section 8 the payment of which would place the indemnified party in a less favorable
net after-Tax position than the indemnified party would have been in if the Tax subject to indemnification and giving rise to such refund had not been deducted, withheld or otherwise imposed and the
indemnification payments or additional amounts with respect to such Tax had never been paid. This Section 8 shall not be construed to require any indemnified party to make available its Tax returns (or any other information relating to its
Taxes that it deems confidential) to the indemnifying party or any other Person. 

  

	9.	 Increased Costs. If any change in applicable law shall subject any Recipient to any Taxes (other than
(A) Indemnified Taxes, (B) Taxes described in clauses (ii) through (iv) of the definition of Excluded Taxes and (C) Connection Income Taxes) on its loans, loan principal, commitments, or other obligations, or its deposits,
reserves, other liabilities or capital attributable thereto, and the result shall be to increase the cost to such Recipient of making, converting to, continuing or maintaining any Term Loan or of maintaining its obligation to make any such Loan, or
to reduce the amount of any sum received or receivable by such Recipient (whether of principal, interest or any other amount), then, upon the request of such Recipient, Borrower will pay to such Recipient such additional amount or amounts as will
compensate such Recipient for such additional costs incurred or reduction suffered. Notwithstanding the foregoing, the Borrower shall not be required to compensate a Recipient pursuant to this Section 9 for any increased costs incurred or
reductions suffered more than nine months prior to the date that such Recipient notifies the Borrower of the change in law giving rise to such increased costs or reductions, and of such Recipient’s intention to claim compensation therefor
(except that, if the change in law giving rise to such increased costs or reductions is retroactive, then the nine-month period referred to above shall be extended to include the period of retroactive effect thereof). 



 

	10.	 Tax Treatment. For United States federal and applicable state and local income Tax purposes, the parties
acknowledge and agree that the Term Loan Advances are being issued with original issue discount within the meaning of Section 1273 of the Code and shall take all Tax reporting positions consistent with the foregoing unless otherwise required by
a governmental authority. 


  

	11.	 Survival. Each party’s obligations under the provisions of this Addendum 1 shall survive the
resignation or replacement of the Agent or any assignment of rights by, or the replacement of, a Lender, the termination of the Term Commitments and the repayment, satisfaction or discharge of all obligations under any Loan Document.




  
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 ADDENDUM 2 to LOAN AND SECURITY AGREEMENT 

(a) Borrower’s Business. For purposes of this Addendum 2, Borrower shall be deemed to include its
“affiliates” as defined in Title 13 Code of Federal Regulations Section 121.103. Borrower represents and warrants to Agent and the Lenders as of each SBA Funding Date and covenants to Agent and the Lenders for a period of one year
after each SBA Funding Date or for such longer period as set forth below with respect to subsections 2, 3, 4, 5, 6 and 7 below, as follows: 
  

	 	1.	 Size Status. Borrower’s primary NAICS code is 325412, and Borrower has less than 1,250 employees in the
aggregate; 


  

	 	2.	 No Relender. Borrower’s primary business activity does not involve, directly or indirectly, providing
funds to others, purchasing debt obligations, factoring, or long-term leasing of equipment with no provision for maintenance or repair; 


  

	 	3.	 No Passive Business. Borrower is engaged in a regular and continuous business operation (excluding the mere
receipt of payments such as dividends, rents, lease payments, or royalties). Borrower’s employees are carrying on the majority of day to day operations. Borrower will not pass through substantially all of the proceeds of the Loan to another
entity; 


  

	 	4.	 No Real Estate Business. Borrower is not classified under North American Industry Classification System (NAICS)
codes 531110 (lessors of residential buildings and dwellings), 531120 (lessors of nonresidential buildings except miniwarehouses), 531190 (lessors of other real estate property), 237210 (land subdivision), or 236117 (new housing for-sale builders). Borrower is not classified under NAICS codes 236118 (residential remodelers), 236210 (industrial building construction), or 236220 (commercial and institutional building construction), if
Borrower is primarily engaged in construction or renovation of properties on its own account rather than as a hired contractor. Borrower is not classified under NAICS codes 531210 (offices of real estate agents and brokers), 531311 (residential
property managers), 531312 (nonresidential property managers), 531320 (offices of real estate appraisers), or 531390 (other activities related to real estate), unless it derives at least 80 percent of its revenue from non-Affiliate sources. The proceeds of the Loan will not be used to acquire or refinance real property unless Borrower (x) is acquiring an existing property and will use at least 51 percent of the usable
square footage for its business purposes; (y) is building or renovating a building and will use at least 67 percent of the usable square footage for its business purposes; or (z) occupies the subject property and uses at least
67 percent of the usable square footage for its business purposes. 


  

	 	5.	 No Project Finance. Borrower’s assets are not intended to be reduced or consumed, generally without
replacement, as the life of its business progresses, and the nature of Borrower’s business does not require that a stream of cash payments be made to the business’s financing sources, on a basis associated with the continuing sale of
assets (e.g., real estate development projects and oil and gas wells). The primary purpose of the 














	 	
Loan is not to fund production of a single item or defined limited number of items, generally over a defined production period, where such production will constitute the majority of the
activities of Borrower (e.g., motion pictures and electric generating plants). 

  

	 	6.	 No Farm Land Purchases. Borrower will not use the proceeds of the Loan to acquire farm land which is or is
intended to be used for agricultural or forestry purposes, such as the production of food, fiber, or wood, or is so taxed or zoned. 


  

	 	7.	 No Foreign Investment. The proceeds of the Loan will not be used substantially for a foreign operation.
Borrower will not have, on or within one year after each SBA Funding Date and each other Loan provided by a Lender that is an SBIC more than 49 percent of its employees or tangible assets located outside the United States of America.



 (b) Small Business Administration Documentation. Agent and the Lenders acknowledge that Borrower completed,
executed and delivered to Agent prior to each SBA Funding Date SBA Forms 480, 652 and 1031 (Parts A and B) together with a business plan showing Borrower’s financial projections (including balance sheets and income and cash flows
statements) for the period described therein and a written statement (whether included in the purchase agreement or pursuant to a separate statement) from Agent regarding its intended use of proceeds from the sale of securities to the Lenders (the
“Use of Proceeds Statement”). Borrower represents and warrants to Agent and the Lenders that the information regarding Borrower and its affiliates set forth in the SBA Form 480, Form 652 and Form 1031 and the Use of
Proceeds Statement delivered as of each SBA Funding Date is accurate and complete. 
 (c) Inspection. The following covenants
contained in this Section (c) are intended to supplement and not to restrict the related provisions of the Loan Documents. Subject to the preceding sentence, once per year at reasonable times not disruptive to Borrower’s
business, Borrower will permit, for so long as the Lenders hold any debt or equity securities of Borrower, Agent, the Lenders or their representative, at Agent’s or the Lenders’ expense, and examiners of the SBA to visit and inspect the
properties and assets of Borrower, to examine its books of account and records, and to discuss Borrower’s affairs, finances and accounts with Borrower’s officers, senior management and accountants, all at such reasonable times as may be
requested by Agent or the Lenders or the SBA. 
 (d) Annual Assessment. Upon request of Agent or Lender, promptly after the end
of each calendar year (but in any event prior to February 28 of each year) and at such other times as may be reasonably requested by Agent or the Lenders, Borrower will deliver to Agent a written assessment of the economic impact of the
Lenders’ investment in Borrower, specifying the full-time equivalent jobs created or retained in connection with the investment, the impact of the investment on the businesses of Borrower in terms of expanded revenue and taxes, other economic
benefits resulting from the investment (such as technology development or commercialization, minority business development, or expansion of exports) and such other information as may be required regarding Borrower in connection with the filing of
the Lenders’ SBA Form 468. The Lenders will assist Borrower with preparing such assessment. In addition to any other rights granted hereunder, Borrower will grant Agent and the Lenders and the SBA access (during regular business hours
and upon reasonable prior notice) to Borrower’s books and records for the purpose of verifying the use of such proceeds. Borrower also will furnish or cause to be furnished to Agent 

  
 Signature Page to Loan
and Security Agreement 












 
and the Lenders such other information regarding the business, affairs and condition of Borrower as Agent or the Lenders may from time to time reasonably request, and such information shall be
certified by the President, Chief Executive Officer or principal accounting officer of Borrower to the extent requested by Agent or Lender for compliance with the SBIC Act. 

(e) Use of Proceeds. Borrower will use the proceeds from the Loan only for purposes set forth in Section 7.17. Borrower will
deliver to Agent from time to time promptly following Agent’s request, a written report, certified as correct by Borrower’s principal accounting officer, verifying the purposes and amounts for which proceeds from the Loan have been
disbursed. Borrower will supply to Agent such additional information and documents as Agent reasonably requests with respect to its use of proceeds and will, to the extent required by Section 7.2, permit Agent and the Lenders and the SBA
to have access (during regular business hours and upon reasonable prior notice) to any and all Borrower records and information and personnel as Agent deems necessary to verify how such proceeds have been or are being used, and to assure that the
proceeds have been used for the purposes specified in Section 7.17. 
 (f) Activities and Proceeds. Neither Borrower nor any of
its affiliates (if any) will engage in any activities or use directly or indirectly the proceeds from the Loan for any purpose for which a small business investment company is prohibited from providing funds by the SBIC Act, including 13 C.F.R.
§107.720. The Borrower shall not, nor shall it cause or permit any of its subsidiaries to, without obtaining the prior written approval of Agent, change within one (1) year of the date hereof the Borrower’s or any such
subsidiary’s business activities from that conducted on the date hereof to a business activity from which a licensee under the SBIC Act is prohibited from providing funds by the SBIC Act. The Borrower agrees that any such change in its or any
such subsidiary’s business activities without such prior written consent of Agent shall constitute a material breach of the obligations of the Borrower under this Addendum 2. 

(g) [Reserved]. 
 (h)
Compliance and Resolution. Borrower agrees that a failure to comply with Borrower’s obligations under this Addendum, or any other set of facts or circumstances where it has been asserted by any governmental regulatory agency (or
Agent or the Lenders believe that there is a substantial risk of such assertion) that Agent, the Lenders and their affiliates are not entitled to hold, or exercise any significant right with respect to, any securities issued to the Lenders by
Borrower, will constitute a breach of the obligations of Borrower under the financing agreements among Borrower, Agent and the Lenders. In the event of (i) a failure to comply with Borrower’s obligations under this Addendum; or
(ii) an assertion by any governmental regulatory agency (or Agent or the Lenders believe that there is a substantial risk of such assertion) of a failure to comply with Borrower’s obligations under this Addendum, then (i) Agent, the
Lenders and Borrower will meet and resolve any such issue in good faith to the satisfaction of Borrower, Agent, the Lenders, and any governmental regulatory agency, and (ii) upon request of the Lenders or Agent, Borrower will cooperate and
assist with any assignment of the financing agreements among Hercules Technology III, L.P. and Hercules Capital, Inc. 

  
 Signature Page to Loan
and Security Agreement 












 ADDENDUM 3 to LOAN AND SECURITY AGREEMENT 

Agent and Lender Terms 
 (a) Each
Lender hereby irrevocably appoints Hercules Capital, Inc. to act on its behalf as the Agent hereunder and under the other Loan Documents and authorizes the Agent to take such actions on its behalf and to exercise such powers as are delegated to the
Agent by the terms hereof or thereof, together with such actions and powers as are reasonably incidental thereto. 
 (b) Each Lender agrees
to indemnify the Agent in its capacity as such (to the extent not reimbursed by Borrower and without limiting the obligation of Borrower to do so), according to its respective Term Commitment percentages (based upon the total outstanding Term
Commitments) in effect on the date on which indemnification is sought under this Addendum 3, from and against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, costs, expenses or disbursements of any kind
whatsoever that may at any time be imposed on, incurred by or asserted against the Agent in any way relating to or arising out of, this Agreement, any of the other Loan Documents or any documents contemplated by or referred to herein or therein or
the transactions contemplated hereby or thereby or any action taken or omitted by the Agent under or in connection with any of the foregoing; The agreements in this Section shall survive the payment of the Loans and all other amounts payable
hereunder. 
 (c) Agent in Its Individual Capacity. The Person serving as the Agent hereunder shall have the same rights and powers in its
capacity as a Lender as any other Lender and may exercise the same as though it were not the Agent and the term “Lender” shall, unless otherwise expressly indicated or unless the context otherwise requires, include each such Person serving
as Agent hereunder in its individual capacity. 
 (d) Exculpatory Provisions. The Agent shall have no duties or obligations except those
expressly set forth herein and in the other Loan Documents. Without limiting the generality of the foregoing, the Agent shall not: 
  

	 	(i)	 be subject to any fiduciary or other implied duties, regardless of whether any default or any Event of Default
has occurred and is continuing; 


  

	 	(ii)	 have any duty to take any discretionary action or exercise any discretionary powers, except discretionary
rights and powers expressly contemplated hereby or by the other Loan Documents that the Agent is required to exercise as directed in writing by the Lenders, provided that the Agent shall not be required to take any action that, in its opinion or the
opinion of its counsel, may expose the Agent to liability or that is contrary to any Loan Document or applicable law; and 


  

	 	(iii)	 except as expressly set forth herein and in the other Loan Documents, have any duty to disclose, and the Agent
shall not be liable for the failure to disclose, any information relating to Borrower or any of its Affiliates that is communicated to or obtained by any Person serving as the Agent or any of its Affiliates in any capacity. 



(e) The Agent shall not be liable for any action taken or not taken by it (i) with the consent or at the request of the Lenders or as the
Agent shall believe in good faith shall be necessary, under the circumstances or (ii) in the absence of its own gross negligence or willful misconduct. 











 (f) The Agent shall not be responsible for or have any duty to ascertain or inquire into
(i) any statement, warranty or representation made in or in connection with this Agreement or any other Loan Document, (ii) the contents of any certificate, report or other document delivered hereunder or thereunder or in connection
herewith or therewith, (iii) the performance or observance of any of the covenants, agreements or other terms or conditions set forth herein or therein or the occurrence of any default or Event of Default, (iv) the validity,
enforceability, effectiveness or genuineness of this Agreement, any other Loan Document or any other agreement, instrument or document or (v) the satisfaction of any condition set forth in Section 4 or elsewhere herein, other than to
confirm receipt of items expressly required to be delivered to the Agent. Reliance by Agent. Agent may rely, and shall be fully protected in acting, or refraining to act, upon, any resolution, statement, certificate, instrument, opinion, report,
notice, request, consent, order, bond or other paper or document that it has no reason to believe to be other than genuine and to have been signed or presented by the proper party or parties or, in the case of cables, telecopies and telexes, to have
been sent by the proper party or parties. In the absence of its gross negligence or willful misconduct, Agent may conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon any certificates or
opinions furnished to Agent and conforming to the requirements of this Agreement or any of the other Loan Documents. Agent may consult with counsel, and any opinion or legal advice of such counsel shall be full and complete authorization and
protection in respect of any action taken, not taken or suffered by Agent hereunder or under any Loan Documents in accordance therewith. Agent shall have the right at any time to seek instructions concerning the administration of the Collateral from
any court of competent jurisdiction. Agent shall not be under any obligation to exercise any of the rights or powers granted to Agent by this Agreement and the other Loan Documents at the request or direction of the Lenders unless Agent shall have
been provided by the Lenders with adequate security and indemnity against the costs, expenses and liabilities that may be incurred by it in compliance with such request or direction. 

  
 Signature Page to Loan
and Security Agreement 












 EXHIBIT A 

ADVANCE REQUEST 
  

					
	 To:
	  	 Agent:
	  	 Date: __________,202[    ]

			
		  	 Hercules Capital, Inc. (the “Agent”)
	  	
		  	 400 Hamilton Avenue, Suite 310
	  	
		  	 Palo Alto, CA 94301

email: legal@htgc.com
	  	
		  	 Attn: Lake Thomas McGuire
	  	

 Kura Oncology, Inc. (“Borrower”) hereby requests from Hercules Capital, Inc. (“Lender”) an Advance in the
amount of _____________________ Dollars ($________________) (the “Advance Amount”) on ______________, _____ (the “Advance Date”) pursuant to the Loan and Security Agreement among Borrower, Agent and the Lender, dated
November 1, 2022 (the “Agreement”). Capitalized words and other terms used but not otherwise defined herein are used with the same meanings as defined in the Agreement. 

Please: 
 (a) Issue a check payable to Borrower
________ 
 or 
 (b) Wire Funds
to Borrower’s account ________ [IF FILED PUBLICLY, ACCOUNT INFO REDACTED FOR SECURITY PURPOSES] 
  

					
		  	Bank:	  	_______________________________________
		  	Address:	  	_______________________________________
		  		  	_______________________________________
		  	ABA Number:	  	_______________________________________
		  	Account Number:	  	_______________________________________
	        	  	Account Name:	  	_______________________________________
		  	Contact Person:	  	_______________________________________
		  	Phone Number	  	_______________________________________
		  	To Verify Wire Info:	  	_______________________________________
		  	Email address:	  	_______________________________________

 Borrower represents that the conditions precedent to the Advance set forth in the Agreement are satisfied and
shall be satisfied upon the making of such Advance, including but not limited to: (i) that no event that has had or would reasonably be expected to have a Material Adverse Effect has occurred and is continuing; (ii) that the
representations and warranties set forth in the Agreement are and shall be true and correct in all material respects on and as of the Advance Date with the same effect as though made on and as of such date, except to the extent such representations
and warranties expressly relate to an earlier date; (iii) that Borrower is in compliance with all the terms and provisions set forth in each Loan Document on its part to be observed or performed; and (iv) that as of the Advance Date, no
fact or condition exists that constitutes (or would, with the passage of time, the giving of notice, or both constitute) an Event of Default under the Loan Documents. Borrower understands and acknowledges that Agent has the right to review the
financial information supporting this representation and, based upon such review in its sole discretion, the Lender may decline to fund the requested Advance. 











 Borrower hereby represents that Borrower’s corporate status and locations have not
changed since the date of the Agreement or, if the Attachment to this Advance Request is completed, are as set forth in the Attachment to this Advance Request. 

Borrower agrees to notify Agent promptly before the funding of the Loan if any of the matters which have been represented above shall not be
true and correct on the Borrowing Date and if Agent has received no such notice before the Advance Date then the statements set forth above shall be deemed to have been made and shall be deemed to be true and correct as of the Advance Date. 

Executed as of [                ],
20[    ]. 
  

			
	 BORROWER: KURA ONCOLOGY, INC.

		
	 SIGNATURE:
	 	 
	 TITLE:
	 	 
	 PRINT NAME:
	 	 



  
 Signature Page to Loan
and Security Agreement 












 ATTACHMENT TO ADVANCE REQUEST 

Dated: _______________________ 
 Borrower hereby
represents and warrants to Agent that Borrower’s current name and organizational status is as follows: 
  

					
		 	Name:	  	[                    ]
			
	        	 	Type of organization:	  	[                    ]
			
		 	State of organization:	  	[                    ]
			
		 	Organization file number:	  	[                    ]

 Borrower hereby represents and warrants to Agent that the street addresses, cities, states and postal codes of its current
locations are as follows: 
 [•] 
 Borrower hereby
represents and warrants to Agent that the Advance Amount does not exceed the Maximum Term Loan Amount as follows: 
  

	a.	 Advance Amount: $________________ 



 

	b.	 Maximum Term Loan Amount: $125,000,000 



 

	c.	 Is clause a. less than or equal to clause b.? Yes/Compliant _______
No/Non-Compliant _______ 



  
 Signature Page to Loan
and Security Agreement 












 EXHIBIT B 

[RESERVED] 











 EXHIBIT C 

[RESERVED] 











 EXHIBIT D 

[RESERVED] 











 EXHIBIT E 

COMPLIANCE CERTIFICATE 
 Hercules Capital,
Inc. (as “Agent”) 
 400 Hamilton Avenue, Suite 310 

Palo Alto, CA 94301 
 Reference is made to that
certain Loan and Security Agreement dated November 1, 2022 and the Loan Documents (as defined therein) entered into in connection with such Loan and Security Agreement all as may be amended from time to time (hereinafter referred to
collectively as the “Loan Agreement”) by and among Hercules Capital, Inc. (the “Agent”), the several banks and other financial institutions or entities from time to time party thereto (collectively, the “Lender”) and
Kura Oncology, Inc. (the “Company”) as Borrower. All capitalized terms not defined herein shall have the same meaning as defined in the Loan Agreement. 

The undersigned is an Officer of the Company, knowledgeable of all Company financial matters, and is authorized to provide certification of
information regarding the Company, hereby certifies, in such capacity, that in accordance with the terms and conditions of the Loan Agreement, the Company is in compliance for the period ending ___________ of all covenants, conditions and terms and
hereby reaffirms that all representations and warranties contained therein are true and correct on and as of the date of this Compliance Certificate with the same effect as though made on and as of such date, except to the extent such
representations and warranties expressly relate to an earlier date, after giving effect in all cases to any standard(s) of materiality contained in the Loan Agreement as to such representations and warranties. Attached are the required documents
supporting the above certification. The undersigned further certifies that these are prepared in accordance with GAAP (except for the absence of footnotes with respect to unaudited financial statement and subject to normal year-end adjustments) and are consistent from one period to the next except as explained below. 
  

					
	REPORTING REQUIREMENT	  	REQUIRED	  	CHECK IF ATTACHED
	Interim Financial Statements	  	If Borrower’s Market Capitalization is less than $750,000,000 – Monthly within 30 days	  	
			
	Interim Financial Statements	  	If Borrower’s Market Capitalization is equal to or greater than $750,000,000 – Quarterly within 45 days	  	
			
	Audited Financial Statements	  	FYE within 90 days	  	

 ACCOUNTS OF BORROWER AND ITS SUBSIDIARIES AND AFFILIATES 

The undersigned hereby also confirms the below disclosed accounts represent all depository accounts and securities accounts presently open in the name of each
Borrower or Borrower’s Subsidiary/Affiliate (other than Excluded Accounts), as applicable. 











 Each new account that has been opened since delivery of the previous Compliance Certificate is designated
below with a “*”. 
  

													
	 	  	 	  	 Depository
 AC #
	  	Financial
Institution	  	 Account
 Type
(Depository
/
Securities)
	  	 Last
 Month

Ending
Account
Balance
	  	Purpose of
Account
	 BORROWER Name/Address:
	  	
		  	1	  		  		  		  		  	
	  	2	  		  		  		  		  	
	  	3	  		  		  		  		  	
	  	4	  		  		  		  		  	
	  	5	  		  		  		  		  	
	  	6	  		  		  		  		  	
	  	7	  		  		  		  		  	
		
	 SUBSIDIARY / AFFILIATE Name/Address
	  	
		  	
		  	1	  		  		  		  		  	
	  	2	  		  		  		  		  	
	  	3	  		  		  		  		  	
	  	4	  		  		  		  		  	
	  	5	  		  		  		  		  	
	  	6	  		  		  		  		  	
	  	7	  		  		  		  		  	

 Financial Covenants. 
 1.
Is Borrower’s Market Capitalization equal to or greater than $1,250,000,000? 











 ___ Yes: No further action needed. 

___ No: Complete (A) or (B) below. 

Complete either (A) or (B) depending on whether the Approval Milestone has been achieved on the date of delivery of this Compliance
Certificate, and please attach supporting documentation: 
 (A) 7.19(a)(i)(x) – Minimum Cash (commencing June 1, 2024, if
the Approval Milestone has not been achieved). 
  

	 	(I)	 Qualified Cash: $___________ 



 

	 	(II)	 55% of the Secured Obligations: $___________ 



Is item (I) above greater than or equal to item (II)? 

___ Yes: In compliance with Section 7.19(a)(i)(x) 

___ No: Not in compliance with Section 7.19(a)(i)(x) 

OR 
 (B) 7.19(a)(i)(y)
– Minimum Cash (commencing June 1, 2024, if the Approval Milestone has been achieved). 
  

	 	(I)	 Qualified Cash: $___________ 



 

	 	(II)	 35% of the Secured Obligations: $___________ 



Is item (I) above greater than or equal to item (II)? 

___ Yes: In compliance with Section 7.19(a)(i)(y) 

___ No: Not in compliance with Section 7.19(a)(i)(y) 

2. Are any Corporate Collaborations (as described in clause (d)(z) of the definition of Permitted License) currently in effect? 

___ No: No further action needed. 
 ___ Yes: Complete
(A) below. 
 (A) 7.19(a)(ii) – Minimum Cash (with respect to Corporate Collaborations). 

 

	 	(I)	 Qualified Cash: $___________ 



 

	 	(II)	 55% of the Secured Obligations: $___________ 



Is item (I) above greater than or equal to item (II)? 

___ Yes: In compliance with Section 7.19(a)(ii) 











 ___ No: Not in compliance with Section 7.19(a)(ii) 

3. Has Borrower made any cash payments in respect of Permitted Convertible Debt subject to satisfaction of the Redemption Conditions? 

___ No: No further action needed. 
 ___ Yes: Complete
(A) below. 
 (A) 7.19(a)(iii) – Minimum Cash (with respect to payments of Permitted Convertible Debt). 

 

	 	(I)	 Qualified Cash: $___________ 



 

	 	(II)	 150% of the Secured Obligations: $___________ 



Is item (I) above greater than or equal to item (II)? 

___ Yes: In compliance with Section 7.19(a)(iii) 

___ No: Not in compliance with Section 7.19(a)(iii) 

 

			
	 Very Truly Yours,

	
	 Kura Oncology, Inc.

	 By:
	 	
		 	  

	 Name:
	 	
		 	  

	 Its:
	 	
		 	  














 EXHIBIT F 

FORM OF JOINDER AGREEMENT 

This Joinder Agreement (the “Joinder Agreement”) is made and dated as of
[                ], 20[ ], and is entered into by and between__________________., a ___________ corporation (“Subsidiary”), and HERCULES CAPITAL, INC., a
Maryland corporation (as “Agent”). 
 RECITALS 

A. Subsidiary’s Affiliate, Kura Oncology, Inc. (“Company”) has entered into that certain Loan and Security Agreement dated
November 1, 2022, with the several banks and other financial institutions or entities from time to time party thereto as lender (collectively, the “Lenders”) and the Agent, as such agreement may be amended (the “Loan
Agreement”), together with the other agreements executed and delivered in connection therewith; 
 B. Subsidiary acknowledges and
agrees that it will benefit both directly and indirectly from Company’s execution of the Loan Agreement and the other agreements executed and delivered in connection therewith; 

AGREEMENT 
 NOW THEREFORE,
Subsidiary and Agent agree as follows: 
  

	1.	 The recitals set forth above are incorporated into and made part of this Joinder Agreement. Capitalized terms
not defined herein shall have the meaning provided in the Loan Agreement. 


  

	2.	 By signing this Joinder Agreement, Subsidiary shall be bound by the terms and conditions of the Loan Agreement
the same as if it were Borrower (as defined in the Loan Agreement) under the Loan Agreement, mutatis mutandis, provided however, that (a) with respect to (i) Section 5.1 of the Loan Agreement, Subsidiary represents that it is an
entity duly organized, legally existing and in good standing under the laws of [                ], (b) neither Agent nor the Lenders shall have any duties,
responsibilities or obligations to Subsidiary arising under or related to the Loan Agreement or the other Loan Documents, (c) that if Subsidiary is covered by Company’s insurance, Subsidiary shall not be required to maintain separate
insurance or comply with the provisions of Sections 6.1 and 6.2 of the Loan Agreement, and (d) that as long as Company satisfies the requirements of Section 7.1 of the Loan Agreement, Subsidiary shall not have to provide Agent separate
Financial Statements. To the extent that Agent or the Lenders has any duties, responsibilities or obligations arising under or related to the Loan Agreement or the other Loan Documents, those duties, responsibilities or obligations shall flow only
to Company and not to Subsidiary or any other Person or entity. By way of example (and not an exclusive list): (i) Agent’s providing notice to Company in accordance with the Loan Agreement or as otherwise agreed among Company, Agent and the
Lenders shall be deemed provided to Subsidiary; (ii) a Lender’s providing an Advance to Company shall be deemed an Advance to Subsidiary; and (iii) Subsidiary shall have no right to request an Advance or make any other demand on the
Lenders. 


  

	3.	 Subsidiary agrees not to certificate its equity securities without Agent’s prior written consent, which
consent may be conditioned on the delivery of such equity securities to Agent in order to perfect Agent’s security interest in such equity securities. 


  

	4.	 Subsidiary acknowledges that it benefits, both directly and indirectly, from the Loan Agreement, and hereby
waives, for itself and on behalf on any and all successors in interest (including without limitation any assignee for the benefit of creditors, receiver, bankruptcy trustee or itself as
debtor-in-possession under any bankruptcy proceeding) to the fullest extent provided by law, any and all claims, rights or















	 	
defenses to the enforcement of this Joinder Agreement on the basis that (a) it failed to receive adequate consideration for the execution and delivery of this Joinder Agreement or
(b) its obligations under this Joinder Agreement are avoidable as a fraudulent conveyance. 

  

	5.	 As security for the prompt, complete and indefeasible payment when due (whether on the payment dates or
otherwise) of all the Secured Obligations, Subsidiary grants to Agent a security interest in all of Subsidiary’s right, title, and interest in and to the Collateral. 



[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 











 [SIGNATURE PAGE TO JOINDER AGREEMENT] 

SUBSIDIARY: 
  

	
	 

  

			
	By:	 	 
	 Name:
	 	 
	 Title:
	 	 
		
	Address:	 	
		
	 Telephone:
	 	 
	 email:
	 	 


 AGENT: 

HERCULES CAPITAL, INC. 

			
	By:	 	 
	Name:	 	 
	Title:	 	 
		
	 Address:
	 	
	 400 Hamilton Ave., Suite 310

Palo Alto, CA 94301

email: legal@htgc.com

Telephone: 650-289-3060
















 EXHIBIT G 

RESERVED 











 EXHIBIT H 

ACH DEBIT AUTHORIZATION AGREEMENT 

Hercules Capital, Inc. 
 400 Hamilton Avenue, Suite 310 

Palo Alto, CA 94301 
 Re: Loan and Security
Agreement dated November 1, 2022 (the “Agreement”) by and among Kura Oncology, Inc. (“Borrower”) and Hercules Capital, Inc., as agent (“Company”) and the lenders party thereto (collectively, the
“Lenders”) 
 In connection with the above referenced Agreement, Borrower hereby authorizes the Company to initiate debit entries for (i) the
periodic payments due under the Agreement and (ii) out-of-pocket legal fees and costs incurred by Agent or the Lenders pursuant to Section 11.12 of the
Agreement to Borrower’s account indicated below. 
 Borrower authorizes the depository institution named below to debit to such account. 

[IF FILED PUBLICLY, ACCOUNT INFO REDACTED FOR SECURITY PURPOSES] 
  

			
	DEPOSITORY NAME	  	BRANCH
	CITY	  	STATE AND ZIP CODE
	TRANSIT/ABA NUMBER	  	ACCOUNT NUMBER

 This authority will remain in full force and effect so long as any amounts are due under the Agreement. 

 

			
	 (Borrower)

		
	 By:
	 	 
		
	 Name:
	 	 
		
	 Date:
	 	 












 EXHIBIT I 

RESERVED 











 EXHIBIT J-1 

FORM OF U.S. TAX COMPLIANCE CERTIFICATE 

(For Foreign Lenders That Are Not Partnerships For U.S. Federal Income Tax Purposes) 

Reference is hereby made to the Loan and Security Agreement dated as of November 1, 2022 (as amended, supplemented or otherwise modified
from time to time, the “Loan Agreement”) by and among Kura Oncology, Inc., a Delaware corporation, and each of its Subsidiaries (as defined in the Loan Agreement) (hereinafter collectively referred to as the “Borrower”), the
several banks and other financial institutions or entities from time to time parties to the Loan Agreement (collectively, referred to as the “Lenders”), and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative
agent and collateral agent for itself and the Lenders (in such capacity, the “Agent”). 
 Pursuant to the provisions of Addendum 1
of the Loan Agreement, the undersigned hereby certifies that (i) it is the sole record and beneficial owner of the Loan(s) (as well as any promissory note(s) evidencing such Loan(s)) in respect of which it is providing this certificate,
(ii) it is not a “bank” within the meaning of Section 881(c)(3)(A) of the Code, (iii) it is not a “ten percent shareholder” of Borrower within the meaning of Section 871(h)(3)(B) of the Code and (iv) it
is not a “controlled foreign corporation” related to Borrower as described in Section 881(c)(3)(C) of the Code. 
 The
undersigned has furnished the Agent and Borrower with a correct and complete certificate of its non-U.S. Person status on IRS Form W-8BEN or IRS Form W-8BEN-E, as applicable (or any successor form). By executing this certificate, the undersigned agrees that (1) if the information provided in this certificate changes,
or if a lapse in time or change in circumstances renders the information on this certificate obsolete, expired or inaccurate in any material respect, the undersigned shall promptly so inform Borrower and the Agent in writing and deliver promptly to
Borrower and the Agent an updated certificate or other appropriate documentation (including any new documentation reasonably requested by Borrower or the Agent) or promptly notify Borrower and the Agent in writing of its inability to do so, and
(2) the undersigned shall have at all times furnished Borrower and the Agent with a properly completed and currently effective certificate in either the calendar year in which each payment is to be made to the undersigned, or in either of the
two calendar years preceding such payments. For the avoidance of doubt, such a certificate described in (2) of the preceding sentence shall be updated and provided by the undersigned to the Agent and Borrower prior to the next applicable
payment date following a change described in (1) of the preceding sentence. 
 Unless otherwise defined herein, terms defined in the
Loan Agreement and used herein shall have the meanings given to them in the Loan Agreement. 
  

							
	Date: _____________ ___, 20___	 		 	[NAME OF LENDER]
				
		 		 	By:	 	 
				
		 		 	Name:	 	 
				
		 		 	Title:	 	 












 EXHIBIT J-2 

FORM OF U.S. TAX COMPLIANCE CERTIFICATE 

(For Foreign Participants That Are Not Partnerships For U.S. Federal Income Tax Purposes) 

Reference is hereby made to the Loan and Security Agreement dated as of November 1, 2022 (as amended, supplemented or otherwise modified
from time to time, the “Loan Agreement”) by and among Kura Oncology, Inc., a Delaware corporation, and each of its Subsidiaries (as defined in the Loan Agreement) (hereinafter collectively referred to as the “Borrower”), the
several banks and other financial institutions or entities from time to time parties to the Loan Agreement (collectively, referred to as the “Lenders”), and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative
agent and collateral agent for itself and the Lenders (in such capacity, the “Agent”). 
 Pursuant to the provisions of Addendum 1
of the Loan Agreement, the undersigned hereby certifies that (i) it is the sole record and beneficial owner of the participation in respect of which it is providing this certificate, (ii) it is not a “bank” within the meaning of
Section 881(c)(3)(A) of the Code, (iii) it is not a “ten percent shareholder” of Borrower within the meaning of Section 871(h)(3)(B) of the Code and (iv) it is not a “controlled foreign corporation” related to
Borrower as described in Section 881(c)(3)(C) of the Code. 
 The undersigned has furnished its participating Lender with a correct and
complete certificate of its non-U.S. Person status on IRS Form W-8BEN or IRS Form
W-8BEN-E, as applicable (or any successor form). By executing this certificate, the undersigned agrees that (1) if the information provided in this certificate
changes, or if a lapse in time or change in circumstances renders the information on this certificate obsolete, expired or inaccurate in any material respect, the undersigned shall promptly so inform such Lender in writing and deliver promptly to
such Lender an updated certificate or other appropriate documentation (including any new documentation reasonably requested by such Lender) or promptly notify such Lender in writing of its inability to do so, and (2) the undersigned shall have
at all times furnished such Lender with a properly completed and currently effective certificate in either the calendar year in which each payment is to be made to the undersigned, or in either of the two calendar years preceding such payments. For
the avoidance of doubt, such a certificate described in (2) of the preceding sentence shall be updated and provided by the undersigned to its participating Lender prior to the next applicable payment date following a change described in
(1) of the preceding sentence. 
 Unless otherwise defined herein, terms defined in the Loan Agreement and used herein shall have the
meanings given to them in the Loan Agreement. 
  

							
	Date: _____________ ___, 20___	 		 	[NAME OF PARTICIPANT]
				
		 		 	By:	 	 
				
		 		 	Name:	 	 
				
		 		 	Title:	 	 












 EXHIBIT J-3 

FORM OF U.S. TAX COMPLIANCE CERTIFICATE 

(For Foreign Participants That Are Partnerships For U.S. Federal Income Tax Purposes) 

Reference is hereby made to the Loan and Security Agreement dated as of November 1, 2022 (as amended, supplemented or otherwise modified
from time to time, the “Loan Agreement”) by and among Kura Oncology, Inc., a Delaware corporation, and each of its Subsidiaries (as defined in the Loan Agreement) (hereinafter collectively referred to as the “Borrower”), the
several banks and other financial institutions or entities from time to time parties to the Loan Agreement (collectively, referred to as the “Lenders”), and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative
agent and collateral agent for itself and the Lenders (in such capacity, the “Agent”). 
 Pursuant to the provisions of Addendum 1
of the Loan Agreement, the undersigned hereby certifies that (i) it is the sole record owner of the participation in respect of which it is providing this certificate, (ii) its direct or indirect partners/members are the sole beneficial
owners of such participation, (iii) with respect to such participation, neither the undersigned nor any of its direct or indirect partners/members is a “bank” extending credit pursuant to a loan agreement entered into in the ordinary
course of its trade or business within the meaning of Section 881(c)(3)(A) of the Code, (iv) none of its direct or indirect partners/members is a “ten percent shareholder” of Borrower within the meaning of
Section 871(h)(3)(B) of the Code and (v) none of its direct or indirect partners/members is a “controlled foreign corporation” related to Borrower as described in Section 881(c)(3)(C) of the Code. 

The undersigned has furnished its participating Lender with a correct and complete IRS Form W-8IMY
accompanied by one of the following forms from each of its partners/members that is claiming the portfolio interest exemption: (i) an IRS Form W-8BEN or IRS Form W-8BEN-E, as applicable (or any successor form) or (ii) an IRS Form W-8IMY accompanied by an IRS Form W-8BEN or IRS Form W-8BEN-E, as applicable (or any successor form), from each of such partner’s/member’s beneficial owners that is claiming the portfolio interest exemption. By
executing this certificate, the undersigned agrees that (1) if the information provided in this certificate changes, or if a lapse in time or change in circumstances renders the information on this certificate obsolete, expired or inaccurate in
any material respect, the undersigned shall promptly so inform such Lender and deliver promptly to such Lender an updated certificate or other appropriate documentation (including any new documentation reasonably requested by such Lender) or
promptly notify such Lender in writing of its inability to do so, and (2) the undersigned shall have at all times furnished such Lender with a properly completed and currently effective certificate in either the calendar year in which each
payment is to be made to the undersigned, or in either of the two calendar years preceding such payments. For the avoidance of doubt, such a certificate described in (2) of the preceding sentence shall be updated and provided by the undersigned
to its participating Lender prior to the next applicable payment date following a change described in (1) of the preceding sentence. 

Unless otherwise defined herein, terms defined in the Loan Agreement and used herein shall have the meanings given to them in the Loan
Agreement. 
  

							
	Date: _____________ ___, 20___	 		 	[NAME OF PARTICIPANT]
				
		 		 	By:	 	 
				
		 		 	Name:	 	 
				
		 		 	Title:	 	 












 EXHIBIT J-4 

FORM OF U.S. TAX COMPLIANCE CERTIFICATE 

(For Foreign Lenders That Are Partnerships For U.S. Federal Income Tax Purposes) 

Reference is hereby made to the Loan and Security Agreement dated as of November 1, 2022 (as amended, supplemented or otherwise modified
from time to time, the “Loan Agreement”) by and among Kura Oncology, Inc., a Delaware corporation, and each of its Subsidiaries (as defined in the Loan Agreement) (hereinafter collectively referred to as the “Borrower”), the
several banks and other financial institutions or entities from time to time parties to the Loan Agreement (collectively, referred to as the “Lenders”), and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative
agent and collateral agent for itself and the Lenders (in such capacity, the “Agent”). 
 Pursuant to the provisions of Addendum 1
of the Loan Agreement, the undersigned hereby certifies that (i) it is the sole record owner of the Loan(s) (as well as any promissory note(s) evidencing such Loan(s)) in respect of which it is providing this certificate, (ii) its direct
or indirect partners/members are the sole beneficial owners of such Loan(s) (as well as any promissory note(s) evidencing such Loan(s)), (iii) with respect to the extension of credit pursuant to this Loan Agreement or any other Loan Document,
neither the undersigned nor any of its direct or indirect partners/members is a “bank” extending credit pursuant to a loan agreement entered into in the ordinary course of its trade or business within the meaning of
Section 881(c)(3)(A) of the Code, (iv) none of its direct or indirect partners/members is a “ten percent shareholder” of Borrower within the meaning of Section 871(h)(3)(B) of the Code and (v) none of its direct or
indirect partners/members is a “controlled foreign corporation” related to Borrower as described in Section 881(c)(3)(C) of the Code. 

The undersigned has furnished the Agent and Borrower with a correct and complete IRS Form W-8IMY
accompanied by one of the following forms from each of its partners/members that is claiming the portfolio interest exemption: (i) an IRS Form W-8BEN or IRS Form W-8BEN-E, as applicable (or any successor form) or (ii) an IRS Form W-8IMY accompanied by an IRS Form W-8BEN or IRS Form W-8BEN-E, as applicable (or any successor form), from each of such partner’s/member’s beneficial owners that is claiming the portfolio interest exemption. By
executing this certificate, the undersigned agrees that (1) if the information provided in this certificate changes, or if a lapse in time or change in circumstances renders the information on this certificate obsolete, expired or inaccurate in
any material respect, the undersigned shall promptly so inform Borrower and the Agent in writing and deliver promptly to Borrower and the Agent an updated certificate or other appropriate documentation (including any new documentation reasonably
requested by Borrower or the Agent) or promptly notify Borrower and the Agent in writing of its inability to do so, and (2) the undersigned shall have at all times furnished Borrower and the Agent with a properly completed and currently
effective certificate in either the calendar year in which each payment is to be made to the undersigned, or in either of the two calendar years preceding such payments. For the avoidance of doubt, such a certificate described in (2) of the
preceding sentence shall be updated and provided by the undersigned to the Agent and Borrower prior to the next applicable payment date following a change described in (1) of the preceding sentence. 

Unless otherwise defined herein, terms defined in the Loan Agreement and used herein shall have the meanings given to them in the Loan
Agreement. 
  

							
	Date: _____________ ___, 20___	 		 	[NAME OF LENDER]
				
		 		 	By:	 	 
				
		 		 	Name:	 	 
				
		 		 	Title:	 	 












 SCHEDULE 1.1 

COMMITMENTS 
  

																									
	 LENDERS
	  	Tranche 1A
Commitment	 	  	Tranche 1B
Commitment	 	  	Tranche 2
Commitment	 	  	Tranche 3
Commitment	 	  	Tranche 4
Commitment*	 	  	TERM
COMMITMENT	 
	 Hercules Capital, Inc.
	  	 	—  	 	  	$	8,250,000	 	  	$	19,250,000	 	  	$	22,000,000	 	  	$	25,000,000	 	  	$	74,500,000	 
	 Hercules Capital IV, L.P.
	  	$	5,500,000	 	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	$	5,500,000	 
	 Hercules Private Credit Fund 1 LP
	  	$	2,500,000	 	  	$	3,750,000	 	  	$	8,750,000	 	  	$	10,000,000	 	  	 	—  	 	  	$	25,000,000	 
	 Hercules Private Global Venture Growth Fund I LP
	  	$	2,000,000	 	  	$	3,000,000	 	  	$	7,000,000	 	  	$	8,000,000	 	  	 	—  	 	  	$	20,000,000	 
	 TOTAL COMMITMENTS
	  	$	10,000,000	 	  	$	15,000,000	 	  	$	35,000,000	 	  	$	40,000,000	 	  	$	25,000,000	 	  	$	125,000,000	 

  

	*Funding	 of Tranche 4 is subject to approval by Lenders’ investment committee in its sole discretion.