Docket Number: EPA–HQ–OPP–2010–0241 

www.regulations.gov 

 

 

United States Chemical Safety and June 2010 

Environmental Protection Pollution Prevention 

Agency (7510P)

Busan 74 Summary Document: Registration Review 

Docket Number: EPA–HQ–OPP–2010–0241 

www.regulations.gov 

TABLE OF CONTENTS

Busan 74 Registration Review Team Members........................................... 1

I. Preliminary Work Plan..................................................................... 2

II. Fact Sheet.................................................................................... 10

III. Glossary of Terms and Abbreviations................................................ 13

IV. Appendix A................................................................................. 15
Docket Number: EPA–HQ–OPP–2010–0004 

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Busan 74 Registration Review Team

Human Health & Environmental Effects 

Timothy Dole 

Srinivas Gowda 

Risk Management

K. Avivah Jakob 

Rebecca von dem Hagen 

Lance Wormell 

Office of General Counsel

Philip Ross 

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I. PRELIMINARY WORK PLAN – Busan 74

Introduction

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review 

program. All pesticides distributed or sold in the United States generally must be 

registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the Agency), 

based on scientific data showing that they will not cause unreasonable risks to human 

health or the environment when used as directed on product labeling. The registration 

review program is intended to make sure that, as the ability to assess risk evolves and as 

policies and practices change, all registered pesticides continue to meet the statutory 

standard of no unreasonable adverse effects to human health or the environment. 

Changes in science, public policy, and pesticide use practices will occur over time. 

Through the registration review program, the Agency periodically reevaluates pesticides 

to make sure that as change occurs, products in the marketplace can be used safely. 

Information on this program is provided at 

http://www.epa.gov/oppsrrd1/registration_review/. 

The Agency is implementing the registration review program pursuant to Section 3(g) 

of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each 

registered pesticide every 15 years to determine whether it continues to meet the FIFRA 

standard for registration. The Agency will consider benefits information and data as 

required by FIFRA. The public phase of registration review begins when the initial 

docket is opened for each case. The docket is the Agency’s opportunity to state what it 

knows about the pesticide and what additional risk analyses and data or information it 

believes are needed to make a registration review decision. After reviewing and 

responding to comments and data received in the docket during this initial comment 

period, the Agency will develop and commit to a final work plan and schedule for the 

registration review of Busan 74. 

 The chemical name for the active ingredient in this registration review case is 2-

hydroxypropyl methanethiolsulfonate (HPMTS). Busan 74 is a trade name that refers to 

a product, which is no longer registered, that contained HPMTS as an active ingredient. 

Although the name for this registration review case is Busan 74, hence forward this case 

will be referred to by its chemical name, 2-hydroxypropyl- methanethiolsulfonate 

(HPMTS). 

HPMTS was first registered in the United States in 1968. There are currently no 

registered end-use products for HPMTS. There is one registered product (EPA Reg. 

No.1448-31) that contains HPMTS as the active ingredient (ai). This product is a 

manufacturing use product (MP) for formulating use only. A Reregistration Eligibility 

Decision (RED) for HPMTS was issued in 1995. The RED can be located at: 

http://www.epa.gov/pesticides/reregistration/status.htm. At the time the HPMTS 

Reregistration Eligibility Decision (RED) was written, there was one registrant and nine 

registered products. The end-use products (EP) existing at the time of the RED were 

registered for use as materials preservatives (industrial coatings, paints, emulsions, wet2 
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end additives) and for treatment of industrial cooling water systems and pulp and paper 

mill water systems. Although these uses were found to be eligible for reregistration, all 

of the end-use products were voluntarily cancelled after the RED was issued. As a result 

of these product cancellations, there are no remaining registered end-uses or end-use 

products containing HPMTS. 

Risk Assessment Status & Anticipated Risk Assessment and Data Needs

Human Health Risk Assessment Status 

There are no registered end-uses or end-use products for HPMTS. The one registered 

manufacturing use product does not contain any information on application rates or use 

directions. Human exposures that occur during the formulation of a pesticide product are 

regulated by the Occupational Safety and Health Administration (OSHA) and are not 

under the jurisdiction of the EPA. Therefore, because the EPA does not asses exposures 

that may occur during the formulation of a pesticide product and there are no registered 

HPMTS end-uses or end-use products that would result in human exposure, human 

exposure assessments are not anticipated as being needed to ensure that this registration 

review case meets the FIFRA and FFDCA standards. For further information see 

“Summary of Human Health Effects Data for the HPMTS Registration Review,” dated 

May 26, 2010. 

Tolerances

 There are no tolerances or exceptions from the need to establish tolerances for 

HPMTS. 

Aggregate and Cumulative Exposure and Risk

In examining aggregate exposure, EPA takes into account the available and reliable 

information concerning exposures to pesticide residues in food and drinking water, as 

well as non-occupational pesticide exposures. An aggregate risk assessment is not 

needed for HPMTS because there are no registered end-uses or end-use products that will 

result in residential exposure. 

 Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to 

establish, modify, or revoke a tolerance, the Agency consider “available information” 

concerning the cumulative effects of a particular pesticide's residues and “other 

substances that have a common mechanism of toxicity.” EPA has not yet determined 

whether HPMTS has a common mechanism with other compounds; consequently, a 

cumulative assessment is not anticipated at this time. 

Anticipated Human Health Data Needs 

As previously mentioned, there are no registered end-uses and end-use products for 

HPMTS and the registered manufacturing use product is for formulating use only. 

Because there are no registered end-uses that would result in dietary, drinking water, 

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residential or occupational exposure to HPMTS, human exposure and risk assessments 

are not needed in support of this registration review. 

However, the Agency anticipates that an acute inhalation toxicity study (GLN 

870.1300) will be needed to fulfill standard acute toxicology data requirements as 

outlined in 40 CFR 161.340. Based upon 40 CFR 161.340 Toxicology Data 

Requirements, a standard battery of acute toxicity and mutagenicity tests are required for 

all antimicrobial pesticides regardless of use pattern. The requirement for an acute 

inhalation toxicity study was waived in support of the HPMTS RED because it was 

believed that the uses that existed at that time would not result in the generation of 

respirable particles. However, this rationale is no longer considered to be valid because 

non-respirable particles and aerosols can have portal of entry and respiratory tract effects. 

This is particularly true for HPMTS, which caused corrosive effects in the 14- and 90-day 

dermal studies. 

The Agency anticipates that the following toxicity data will be needed to support the 

HPMTS manufacturing use product registration. 

Anticipated Toxicity Data Needs

 (GLN 870.1300) Acute Inhalation Toxicity 

It should be noted that the Agency likely would not anticipate needing an acute 

inhalation toxicity study at this time if the registration were amended to add the following 

label restriction to the manufacturing use product registration label for EPA Reg. No. 

1448-31: “This product may not be sold, distributed, or used.” If this language is added 

to the label the product may not be sold, distributed, or used until (1) the label for this 

product is amended to add specific use patterns, (2) an end-use registration application is 

submitted for each use pattern listed on the manufacturing use label, (3) all data 

necessary to support the application are submitted, reviewed and found acceptable and 

(4) the end-use product is registered for the proposed uses. Should the registrant 

voluntarily amend its product registration and label with this language and then 

subsequently submit a registration amendment to remove that language from the label, an 

acute inhalation study and any other data that the Agency determined were necessary to 

support the product registration at that time would be needed. 

If in the future a registrant were to apply for a new HPMTS product registration, the 

necessary risk assessments would be conducted by the Agency at that time to assess 

possible exposure and risk resulting from the proposed new use(s). 

Anticipated Physical/Chemical Property Data Needs 

All product chemistry data requirements have been fulfilled for HPMTS. Therefore, 

it is anticipated that additional product chemistry data will not be needed for HPMTS. 

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Environmental Fate and Ecological Risk Assessment Status 

There are no registered end-uses or end-use products for HPMTS. The registered 

manufacturing use product is for formulating use only and will not result in 

environmental exposure. Because there are no registered uses that would result in 

environmental exposure to HPMTS, environmental fate and ecological risk assessments 

are not needed at this time to ensure that this registration review case meets the FIFRA 

and FFDCA standards. For further information see “Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the HPMTS Registration Review Decision 

Document,” dated May 19, 2010. 

Anticipated Environmental Fate and Ecological Data Needs 

As previously mentioned, there are no registered end-uses or end-use products for 

HPMTS. The registered manufacturing use product is for formulating use only and will 

not result in environmental exposure. Because there are no registered uses that would 

result in environmental exposure to HPMTS, environmental fate and ecological risk 

assessments are not needed in support of this registration review. 

Endangered Species 

Labels may be categorized into two types: labels for manufacturing uses and label for 

end-use products. Manufacturing use products are not used directly in the environment, 

but instead, are used to make formulated or end-use products. End-use products are used 

to control a pest and carry label instructions that indicate how the product may legally be 

used. There are currently no registered end-use products for HPMTS; the only 

registration is for the manufacturing use product. There is no environmental exposure 

anticipated and the Agency has determined the registration of the manufacturing use 

product will have "no effect" (NE) on endangered or threatened terrestrial or aquatic 

species, or their designated critical habitats, as listed by the U.S. Fish and Wildlife 

Service (USFWS) and the National Oceanic and Atmospheric Administration (NOAA). 

Therefore, no additional environmental risk assessment is anticipated to be undertaken. 

However, the EPA will review any comments made by the public on this document and 

will conduct an environmental risk assessment, if new information warrants such action. 

If such a decision is made, the environmental risk assessment will conclude that the 

registered pesticide's use has “no effect” or “may affect” federally listed threatened or 

endangered species (listed species) or their designated critical habitats. When an 

assessment concludes that a pesticide’s use “may affect” a listed species or its designated 

critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or 

National Marine Fisheries Service (the Services), as appropriate.

 

Incidents

Federal law requires registrants of pesticides to inform EPA about any harmful effects 

of their products. No HPMTS incidents have been reported in the OPP Incident Data 

System (IDS). 

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Timeline

The EPA has created the following estimated timeline for the completion of the 

HPMTS registration review case. The Agency anticipates requiring additional data for 

this registration review case. 

Anticipated Schedule

Registration Review for HPMTS 

Projected Registration Review Timeline 

Activities Time 

Opening Docket 

Open Public Comment Period for HPMTS Docket June 2010 

Close Public Comment Period August 2010 

Case Development 

Develop Final Work Plan (FWP) December 2010 

Issue Final DCI December 2011 

Data Submission December 2012 

Registration Review Decision 

Open Public Comment Period for Proposed RR Decision May 2013 

Close Public Comment Period August 2013 

Final Decision 2013 

Total (years) 4 years 

Guidance for Commenters

The public is invited to comment on the Agency’s preliminary registration review 

work plan and rationale. The Agency will consider all comments as well as any 

additional information or data provided in a timely manner prior to issuing a final work 

plan (FWP) for the HPMTS case. 

Trade Irritants 

Through the registration review process, the Agency intends to solicit information on 

trade irritants and, to the extent feasible, take steps toward facilitating irritant resolution. 

Growers and other stakeholders are asked to comment on any trade irritant issues 

resulting from lack of Maximum Residue Limits (MRLs) or disparities between U.S. 

tolerances and MRLs in key export markets, providing as much specificity as possible 

regarding the nature of the concern. 

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Water Quality 

HPMTS is not identified as a cause of impairment for any water bodies listed as 

impaired under section 303(d) of the Clean Water Act, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_grou

p_id=885. In addition, no Total Maximum Daily Loads (TMDL) have been developed 

for HPMTS, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_gr

oup_id=885&p_pollutant_group_name=PESTICIDES. More information on impaired 

water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/. The Agency 

invites submission of water quality data for this pesticide. To the extent possible, data 

should conform to the quality standards in Appendix A of the OPP Standard Operating 

Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s 

Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm) in order to 

ensure they can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice 

The EPA seeks to achieve environmental justice, the fair treatment and meaningful 

involvement of all people, regardless of race, color, national origin, or income, in the 

development, implementation, and enforcement of environmental laws, regulations, and 

policies. To help address potential environmental justice issues, the Agency seeks 

information on any groups or segments of the population who, as a result of their 

location, cultural practices, or other factors, may have atypical, unusually high exposure 

to HPMTS, compared to the general population. Please comment if you are aware of any 

sub-populations that may have atypical, unusually high exposure compared to the general 

population. 

Structure Activity Relationships 

EPA must rely upon information of appropriate quality and reliability for each 

decision made by the Agency. In the Office of Pesticide Programs (OPP), the evaluation 

process for a pesticide chemical traditionally begins with the applicant’s submission of a 

set of studies conducted with the specific pesticide chemical of interest. The use of the 

results of such testing (measured data) is a logical, scientifically rigorous process that 

identifies the physical, chemical, and environmental fate properties of the pesticide, as 

well as the dose and endpoints at which an adverse effect can occur in various animal 

species. 

Today, there is significant interest in alternative techniques, i.e., techniques other than 

data generation that could significantly inform the Agency’s decision-making process. 

Recently, OPP has made increasing use of structure activity relationship (SAR) as part of 

its regulatory decision-making process. In the SAR process, a chemical's molecular 

structure is compared to that of other chemicals for which data are available. These 

structural similarities are then used to make predictive judgments about a chemical’s 

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physical, chemical, and biological properties. Thus, the chemical’s physical, chemical, 

and biological properties are a function of (or directly related to) the chemical’s 

molecular structure. Quantitative SAR is referred to as QSAR. To develop a QSAR, a 

selected set of measured data on a single physical, chemical, or biological property is 

used to derive a model (an equation) to predict the value of that property. 

 Since SAR assessments and QSAR modeling are another set of tools that are 

available to Agency scientists, OPP has begun a process shift that envisions shifting from 

the current study-by-study approach to an approach in which the use of predicted data, 

generated using validated models, is considered along with information from open 

literature and studies specifically generated under Part 161 requirements. All relevant 

information would be considered as part of a weight-of-the-evidence evaluation. 

 At this time, EPA believes that for certain endpoints, especially physical/chemical 

and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data 

requirements for many antimicrobial pesticide chemicals. When considering biological 

properties, at this time, EPA believes that SAR and QSAR can be most effectively 

utilized in the evaluation of chemicals that exhibit lower toxicity for human health and/or 

ecotoxicity parameters. This is appropriate because the risk assessment for lower toxicity 

chemicals can be stream-lined, i.e., a screening-level assessment procedure rather than 

multiple tiers of assessments with progressively more data requirements. 

 If stakeholders believe that submission of data may affect this registration review case 

for HPMTS, then the Agency invites submission of this information. The submitter 

would be expected to supply a rationale describing the utility of the information and 

provide documentation on the scientific validity of the information. The determination 

that the predicted data fulfills a data requirement would be at the sole discretion of the 

Agency. Pre-submission consultation with the Agency is encouraged. 

Endocrine Disruptor Screening Program 

As required under FFDCA section 408(p), EPA has developed the Endocrine 

Disruptor Screening Program (EDSP) to determine whether certain substances (including 

pesticide active and other ingredients) may have an effect in humans or wildlife similar to 

an effect produced by a “naturally occurring estrogen, or other such endocrine effects as 

the Administrator may designate.” The EDSP employs a two-tiered approach to making 

the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays 

to identify the potential of a chemical substance to interact with the estrogen, androgen, 

or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening 

and are found to have the potential to interact with E, A, or T hormonal systems will 

proceed to the next stage of the EDSP where EPA will determine which, if any, of the 

Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to 

identify any adverse endocrine related effects caused by the substance, and establish a 

quantitative relationship between the dose and the E, A, or T effect. 

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Between October 2009 and February 2010, EPA issued test orders/data call-ins for 

the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 inert 

ingredients. This list of chemicals was selected based on the potential for human 

exposure through pathways such as food and water, residential activity, and certain postapplication agricultural scenarios. This list should not be construed as a list of known or 

likely endocrine disruptors. 

HPMTS is not among the group of 58 pesticide active ingredients on the initial list to 

be screened under the EDSP. Under FFDCA sec. 408(p) the Agency must screen all 

pesticide chemicals. Accordingly, EPA anticipates issuing future EDSP orders/data callins for all Registration Review cases, including those for which EPA has already opened 

a Registration Review docket for a pesticide active ingredient. 

For further information on the status of the EDSP, the policies and procedures, the list 

of 67 chemicals, the test guidelines and the Tier 1 screening battery, please visit our 

website: http://www.epa.gov/endo/. 

Additional Information 

Stakeholders are also specifically asked to provide available information and data in 

the following areas: 

1. Confirmation on the following label information: 

a. Sites of application 

b. Formulations 

c. Application methods and equipment 

d. Maximum application rates 

e. Frequency of application, application intervals and maximum 

number of applications 

f. Geographic limitations on use 

2. Use or potential use distribution 

3. Use history 

4. Usage/use information for non-agricultural uses (e.g., materials 

preservation) 

5. Typical application interval 

6. State or local use restrictions 

7. Ecological incidents (non-target plant damage and avian, fish, 

reptilian, amphibian and mammalian mortalities) not already reported 

to the Agency 

8. Monitoring data 

9. Structure Activity Relationships 

Next Steps

After the 60-day comment period closes in August 2010, the Agency will review and 

respond to any comments received in a timely manner and then issue a Final Work Plan 

(FWP) for HPMTS. 

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 II. FACT SHEET 

 

Background Information

 Active Ingredient: 2-Hydroxypropyl methanethiolsulfonate (HPMTS) 

 Case Number: 3033 

 PC Code: 035604 

 CAS Registry Number: 30388-01-3 

 Technical Registrant: Buckman Laboratories 

 First approved for use in a registered product: 1968 

 Antimicrobials Division Chemical Review Manager (CRM): Rebecca von dem 

Hagen, VonDem-Hagen.Rebecca@epa.gov 

 Antimicrobials Division Product Manager (PM): Marshall Swindell, 

swindell.marshal@epa.gov

Chemical Identity/Structure

 Empirical Formula: C4H11S203

Use & Usage Information

 There is one registered HPMTS manufacturing use product; it is registered for 

formulating use only. 

 There are no registered end-use products. 

 There are no FDA approvals for HPMTS. 

Earlier Regulatory Actions

 Hydroxypropyl methanethiosulfonate Reregistration Eligibility Decision (RED) 

Document, 1995 

http://www.epa.gov/pesticides/reregistration/status.htm

Human Health Risk Assessment Status

 There are no registered end-uses or end-use products for HPMTS. The one registered 

manufacturing use product does not contain any information on application rates or use 

directions. The manufacturing use product is for formulating use only. Human 

exposures that may occur during the formulation of a pesticide product are regulated by 

the Occupational Safety and Health Administration (OSHA) and are not under the 

jurisdiction of the EPA. Therefore, because the EPA does not asses exposures that may 

occur during the formulation of a pesticide product and there are no registered HPMTS 

end-uses or end-use products that would result in human exposure, human exposure 

assessments are not anticipated as being needed. It is anticipated that an acute inhalation 

toxicity study (GLN 870.1300) will be needed to satisfy the standard battery of acute 

toxicology data requirements as described in 40 CFR 161.340. These data are anticipated 

as being needed to support the continued registration of the sole HPMTS manufacturing 

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use product. Further information and a detailed justification for the data that are expected 

to be required are available in the document titled “Summary of Human Health Effects 

Data for the HPMTS Registration Review,” dated May 26, 2010. 

Product Chemistry Database Status

The Agency has reviewed the product chemistry database for the HPMTS registration 

review case and anticipates that no additional product chemistry data will be needed for 

registration review. Further information is available in the “Summary of Product 

Chemistry, Environmental Fate, and Ecotoxicity Data for the HPMTS Registration 

Review Decision Document,” dated May 19, 2010. 

Ecological Risk Assessment Status

 There are no registered end-use products for HPMTS. Therefore, environmental fate 

and ecological risk assessments are not anticipated as being needed and environmental 

fate and ecological data are not anticipated as being needed in support of the HPMTS 

registration review. Further information is available in the “Summary of Product 

Chemistry, Environmental Fate and Ecotoxicity Data for the HPMTS Registration 

Review Decision Document,” dated May 19, 2010. 

Labels may be categorized into two types: labels for manufacturing uses and label for 

end-use products. Manufacturing use products are not used directly in the environment, 

but instead, are used to make formulated or end-use products. End-use products are used 

to control a pest and carry label instructions that indicate how the product may legally be 

used. There are currently no registered end-use products for HPMTS; the only 

registration is for the manufacturing use product. There is no environmental exposure 

anticipated and the Agency has determined the registration of the manufacturing use 

product will have "no effect" (NE) on endangered or threatened terrestrial or aquatic 

species, or their designated critical habitats, as listed by the U.S. Fish and Wildlife 

Service (USFWS) and the National Oceanic and Atmospheric Administration (NOAA). 

Therefore, no additional environmental risk assessment is anticipated to be undertaken. 

However, the EPA will review any comments made by the public on this document and 

will conduct an environmental risk assessment, if new information warrants such action. 

If such a decision is made, the environmental risk assessment will conclude that the 

registered pesticide's use has “no effect” or “may affect” federally listed threatened or 

endangered species (listed species) or their designated critical habitats. When an 

assessment concludes that a pesticide’s use “may affect” a listed species or its designated 

critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or 

National Marine Fisheries Service (the Services), as appropriate.

Tolerances

 There are no tolerances or exemptions from tolerances for HPMTS as an active 

ingredient and there are no registered food uses. 

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Data Call-In Status

 In September of 1992, EPA issued a GDCI (generic data call-in) for product 

chemistry data, ecological toxicity data and human toxicity data. The data 

requirements for this GDCI have been satisfied. 

 In September of 1993, EPA issued a GDCI for product chemistry data, ecological 

toxicity data, environmental fate data and human toxicity data. The data 

requirements for this GDCI have been satisfied. 

 In February of 1996, EPA issued a PDCI (product specific data call-in) for 

product chemistry data and human toxicity data. The data requirements for this 

PDCI have been satisfied. 

Labels 

There is one registered manufacturing use product that is a part of the HPMTS 

registration review case. The product registration number is listed below. The product 

registration label may be obtained from the Pesticide Product Label System (PPLS) 

website at: http://oaspub.epa.gov/pestlabl/ppls.home. 

Table #1. Registered Active Products of HPMTS 

Registration Number Product Name Company Name 

1448-31 HPMTS Buckman Laboratories Inc. 
Docket Number: EPA–HQ–OPP–2010–0004 

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III. GLOSSARY of TERMS & ABBREVIATIONS

AI Active Ingredient 

AR Anticipated Residue 

ASTM American Society for Testing and Materials 

AWPA American Wood Preserver’s Association 

CBI Confidential Business Information 

CFR Code of Federal Regulations 

cPAD Chronic Population Adjusted Dose 

CSF Confidential Statement of Formula 

CSFII USDA Continuing Surveys for Food Intake by Individuals 

DCI Data Call-In 

DEEM Dietary Exposure Evaluation Model 

DFR Dislodgeable Foliar Residue 

DNT Developmental Neurotoxicity 

DWLOC Drinking Water Level of Comparison 

EC Emulsifiable Concentrate Formulation 

EDWC Estimated Drinking Water Concentration 

EEC Estimated Environmental Concentration 

EP End use Product 

EPA Environmental Protection Agency 

EUP End-Use Product 

FDA Food and Drug Administration 

FIFRA Federal Insecticide, Fungicide, and Rodenticide Act 

FFDCA Federal Food, Drug, and Cosmetic Act 

FQPA Food Quality Protection Act 

FOB Functional Observation Battery 

GENEEC Tier I Surface Water Computer Model 

IR Index Reservoir 

LC50 Median Lethal Concentration. A statistically derived concentration of a 

substance that can be expected to cause death in 50% of test animals. It is 

usually expressed as the weight of substance per weight or volume of water, air 

or feed, e.g., mg/l, mg/kg or ppm. 

LD50 Median Lethal Dose. A statistically derived single dose that can be expected to 

cause death in 50% of the test animals when administered by the route indicated 

(oral, dermal, inhalation). It is expressed as a weight of substance per unit 

weight of animal, e.g., mg/kg. 

LOC Level of Concern 

LOAEL Lowest Observed Adverse Effect Level 

μg/g Micrograms Per Gram 

μg/L Micrograms Per Liter 

mg/kg/day Milligram Per Kilogram Per Day 

mg/L Milligrams Per Liter 

MOE Margin of Exposure 

MRID Master Record Identification (number). EPA's system of recording and tracking 

submitted studies. 

MUP Manufacturing-Use Product 

NA Not Applicable 

NAWQA USGS National Ambient Water Quality Assessment 

NPDES National Pollutant Discharge Elimination System 

NR Not Required 

NOAEL No Observed Adverse Effect Level 

OPP EPA Office of Pesticide Programs 

OPPTS EPA Office of Prevention, Pesticides and Toxic Substances 

PAD Population Adjusted Dose 

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PAIRA Pure Active Ingredient Radiolabelled 

PCA Percent Crop Area 

PDP USDA Pesticide Data Program 

PHED Pesticide Handler's Exposure Data 

PHI Preharvest Interval 

phr Pounds Per Hundred 

ppb Parts Per Billion 

PPE Personal Protective Equipment 

ppm Parts Per Million 

PRZM/EXAMS Tier II Surface Water Computer Model 

Q1* The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer 

Risk Model 

RAC Raw Agriculture Commodity 

RED Reregistration Eligibility Decision 

REI Restricted Entry Interval 

RfD Reference Dose 

RQ Risk Quotient 

RTU Ready to Use 

SCI-GROW Tier I Ground Water Computer Model 

SAP Science Advisory Panel 

SF Safety Factor 

SLN Special Local Need (Registrations Under Section 24©) of FIFRA) 

TGAI Technical Grade Active Ingredient 

TEP Typical End-Use Product 

USDA United States Department of Agriculture 

UF Uncertainty Factor 

WPS Worker Protection Standard
Docket Number: EPA–HQ–OPP–2010–0004 

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Appendix A: Use and Usage Information 2-Hydroxypropyl methanethiolsulfonate (HPM

Use Site Formulation Method of 

Application 

Application Rate/ 

No. of applications 

Use Limi

No registered use sites. For formulating use only. N/A N/A “For formulating use only.” 

“Note: Formulators are responsible registration of products formulated Formulators are also responsible fofor any uses or formulations of this This label is not to be taken as a lic

recommendation to infringe, any p

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