### Division of Toxicology and Hu man Health Sciences ToxFAQs TM 

### October 2012 

# MANGANESE

CAS # 7439-96-5

This fact sheet answers the most frequently asked health questions (FAQs) about manganese. For more information, call the ATSDR Information Center at 1-800- 232-4636. This fact sheet is one in a series of

summaries about hazardous substances and their health effects. It is important you understand this information because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and hab its, and whether other chemicals are present.

What is manganese? Manganese is a naturally occurring metal that is found in many types of rocks. Pure manganese is silver-colored, but does not occur naturally. It combines with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and may be added to some foods.

Manganese is used principally in steel production to improve hardness, stiffness, and strength. It may also be used as an additive in gasoline to improve the octane rating of the gas.



### What happens to manganese when it enters the

environment?

□ Manganese can be released to the air, soil, and waterfrom the manufacture, use, and disposal of manganesebased products.

□ Manganese cannot break down in the environment. It can only change its form or become attached to or separated from particles.

□ In water, manganese tends to attach to particles in the

water or settle into the sediment.

□ The chemical state of manganese and the type of soil determine how fast it moves through the soil and how

much is retained in the soil.

□ The manganese-containing gasoline additive may degrade in the environment quickly when exposed to sunlight, releasing manganese. 

### How might I be exposed to manganese?

□ The primary way you can be exposed to manganese is by eating food or manganese-containing nutritional supplements. Vegetarians, who consume foods rich in manganese such as grains, beans and nuts, as well as heavy tea drinkers, may have a higher intake of manganese than the average person.

□ Certain occupations like welding or working in a factory where steel is made may increase your chances of being exposed to high levels of manganese.

□ Manganese is routinely contained in groundwater, drinking water, and soil at low levels. Drinking water containing manganese or swimming or bathing in water containing manganese may expose you to low levels of

this chemical.



### How can manganese affect my health? Manganese is an essential nutrient, and eating a small amount of it each day is important to stay healthy.

The most common health proble ms in workers exposed to high levels of manganese involve the nervous system. These health effects include behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is re ferred to as “manganism”. Other less severe nervous system effects such as slowed

hand movements have been observed in some workers exposed to lower concentrations in the work place. 

## HIGHLIGHTS: Manganese is a trace elem ent and eating a small amount from

food or water is needed to stay healthy. Exposure to excess levels of manganese may occur from breathing air, partic ularly where manganese is used in manufacturing, and from drinking water and eating food. At high levels, it can cause damage to the brain. Manganese has been foun d in at least 869 of the 1,669 National Priorities List sites id entified by the Environmental Protection Agency (EPA).

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Public Health Service Agency for Toxic Substances and Disease Registry

### ToxFAQs TM 

### Internet address is http:// www.atsdr.cdc.gov/toxfaqs/index.asp

Where can I get more information? For more information, contact the Agency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences, 1600 Clifton Road NE, Mailstop F-57, Atlanta, GA 30333. Phone: 1-800-232-4636

, FAX: 770-488-4178. ToxFAQs Internet address via WWW is http ://www.atsdr.cdc.gov/toxfaqs/index.asp. ATSDR can tell you where to find occupational and envi ronmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting f rom exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns. 

# MANGANESE

CAS # 7439-96-5 Pa g e 2

Federal Recycling Program Printed on Recycled Paper Exposure to high levels of manganese in air can cause lung irritation and reproductive effects.

Nervous system and reproductive effects have been observed in animals after high oral doses of manganese.



### How likely is manganese to cause cancer? The EPA concluded that existing scientific information cannot determine whether or not excess manganese can

cause cancer.



### How can manganese affect children? Studies in children have suggested that extremely high levels of manganese exposure may produce undesirable effects on brain development, including changes in behavior and decreases in the ability to learn and remember. We do not know for certain that these changes were caused by manganese alone. We do not know if these changes are temporary or perm anent. We do not know

whether children are more sensitive than adults to the effects of manganese, but there is some indication from experiments in laboratory animals that they may be.

Studies of manganese workers have not found increases in birth defects or low birth weight in their offspring. No birth defects were observed in animals exposed to

manganese.



### How can families reduce the risk of exposure to manganese?

□ Children are not likely to be exposed to harmful amounts of manganese in the diet. However, higher-than-usual amounts of manganese may be absorbed if their diet is low in iron. It is important to provide your child with a

well-balanced diet.

□ Workers exposed to high levels of airborne manganese in certain occupational settings may accumulatemanganese dust on their work clothes. Manganesecontaminated work clothing should be removed before getting into your car or entering your home to help reduce the exposure hazard for yourself and your family.



### Is there a medical test to determine whether I’ve been exposed to manganese? Several tests are available to measure manganese in blood, urine, hair, or feces. Because manganese is normally present in our body, some is always found in tissues or

fluids.

Because excess manganese is usually removed from the body within a few days, past exposures are difficult to measure with common laboratory tests.



### Has the federal government made recommendations to protect human health? The EPA has determined that exposure to manganese in drinking water at concentrations of 1 mg/L for up to 10 days is not expected to cause any adverse effects in a

child.

The EPA has established that lifetime exposure to 0.3 mg/L manganese is not expected to cause any adverse effects.

The FDA has determined that the manganese concentration in bottled drinking water should not exceed 0.05 mg/L.

The Occupational Health and Safety Administration (OSHA) has established a ceiling limit (concentration that

should not be exceeded at an y time during exposure) of 5 mg/m 3 for manganese in workplace air.



### References Agency for Toxic Substan ces and Disease Registry (ATSDR). 2012. Toxicological Profile for Manganese. Atlanta, GA: U.S. Department of Public Health and Human Services, Public Health Service.