Federal Register / Vol. 69, No. 245 / Wednesday, December 22, 2004 / Notices 76769

of substances in combination with other 

substances with which they are 

commonly found. The Food Quality 

Protection Act (FQPA) of 1996 requires 

that factors to be considered in 

establishing, modifying, or revoking 

tolerances for pesticide chemical 

residues shall include the available 

information concerning the cumulative 

effects of substances that have a 

common mechanism of toxicity, and 

combined exposure levels to the 

substance and other related substances. 

The FQPA requires that the 

Administrator of the Environmental 

Protection Agency consult with the 

Secretary of the Department of Health 

and Human Services (which includes 

ATSDR) in implementing some of the 

provisions of the act.

To carry out these legislative 

mandates, ATSDR has developed a 

chemical mixtures program. As part of 

the mixtures program, ATSDR 

developed a guidance manual that 

outlines the latest methods for mixtures 

health assessment. In addition, a series 

of documents called interaction profiles 

are being developed for certain priority 

mixtures that are of special concern to 

ATSDR. The purpose of an interaction 

profile is to evaluate data on the 

toxicology of the ‘‘whole’’ priority 

mixture (if available) and on the joint 

toxic action of the chemicals in the 

mixture in order to recommend 

approaches for the exposure-based 

assessment of the potential hazard to 

public health. 

All the documents were submitted to 

both the peer-review and the public 

review processes. Changes in the 

documents reflect those addressing 

reviewers’ comments. 

The following documents were made 

available to the public in October 2004. 

Document 1 

Guidance manual for the assessment 

of joint toxic action of chemical 

mixtures. 

Document 2 

Interaction profile for persistent 

chemicals found in fish. Chlorinated 

dibenzo-p-dioxins (CDDs), 

hexachlorobenzene, dichlorodiphenyl 

dichloroethane (p,p′-DDE), methyl 

mercury, and polychlorinated biphenyls 

(PCBs). 

Document 3 

Interaction profile for persistent 

chemicals found in breast milk. 

Chlorinated dibenzo-p-dioxins (CDDs), 

hexachlorobenzene, dichlorodiphenyl 

dichloroethane (p,p′-DDE), methyl 

mercury, and polychlorinated biphenyls 

(PCBs). 

Document 4 

Interaction profile for 1,1,1-

trichloroethane, 1,1-dichloroethane, 

trichloroethylene, and 

tetrachloroethylene. 

Document 5 

Interaction profile for benzene, 

ethylbenzene, toluene, and xylenes 

(BTEX). 

Document 6 

Interaction profile for arsenic, 

cadmium, chromium, and lead. 

Document 7 

Interaction profile for copper, lead, 

manganese, and zinc. 

Document 8 

Interaction profile for cesium, cobalt, 

polychlorinated biphenyls, strontium, 

and trichloroethylene. 

Document 9 

Interaction profile for arsenic, 

hydrazines, jet fuels, strontium, 

trichloroethylene. 

Document 10 

Interaction profile for cyanide, 

fluoride, nitrate, and uranium. 

Two additional Interaction Profiles 

[Drafts for Public Comments] 

Interaction profile for atrazine 

deethylatrazine, diazinon, simazine, and 

nitrate. 

Interaction profile for chlorpyrifos, 

lead, mercury, and methylmercury.

Dated: December 16, 2004. 

Georgi Jones, 

Director, Office of Policy, Planning, and 

Evaluation, National Center for 

Environmental Health and Agency for Toxic 

Substances and Disease Registry.

[FR Doc. 04–27954 Filed 12–21–04; 8:45 am] 

BILLING CODE 4163–70–P

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

Disease, Disability, and Injury 

Prevention and Control Special 

Emphasis Panel (SEP): Environmental 

Health Specialist Network, Program 

Announcement Number (PA) 05013 

In accordance with Section 10(a)(2) of 

the Federal Advisory Committee Act 

(Pub. L. 92–463), the Centers for Disease 

Control and Prevention (CDC) 

announces the following meeting:

Name: Disease, Disability, and Injury 

Prevention and Control Special Emphasis 

Panel (SEP): Environmental Health Specialist 

Network, PA Number 05013. 

Times and Dates: 9 a.m.–9:30 a.m., January 

25, 2005 (Open), 9:30 a.m.–5 p.m., January 

25, 2005 (Closed). 

Place: Hilton Atlanta Airport, 1031 

Virginia Avenue, Atlanta, GA 30354, 

Telephone Number 404 767–9000. 

Status: Portions of the meeting will be 

closed to the public in accordance with 

provisions set forth in Section 552b(c)(4) and 

(6), Title 5 U.S.C., and the Determination of 

the Director, Management Analysis and 

Services Office, CDC, pursuant to Public Law 

92–463. 

Matters To Be Discussed: The meeting will 

include the review, discussion, and 

evaluation of applications received in 

response to: Environmental Health Specialist 

Network, PA Number 05013. 

Contact Person for Further Information:

Mildred Williams-Johnson, PhD, Scientific 

Review Administrator, Centers for Disease 

Control, National Center for Environmental 

Health, 1600 Clifton Road NE., Mailstop E28, 

Atlanta, GA 30333, Telephone (404) 498–

0639. 

The Director, Management Analysis and 

Services Office, has been delegated the 

authority to sign Federal Register notices 

pertaining to announcements of meetings and 

other committee management activities, for 

both CDC and the Agency for Toxic 

Substances and Disease Registry.

Dated: December 16, 2004. 

Alvin Hall, 

Director, Management Analysis and Services 

Office, Centers for Disease Control and 

Prevention.

[FR Doc. 04–27950 Filed 12–21–04; 8:45 am] 

BILLING CODE 4163–18–P

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

Disease, Disability, and Injury 

Prevention and Control; Special 

Emphasis Panel (SEP): Fetal Alcohol 

Syndrome Prevention and Surveillance 

in South Africa-Developing 

Community-Level Strategies that Work, 

Request for Applications (RFA) DD05–

011

In accordance with Section 10(a)(2) of 

the Federal Advisory Committee Act 

(Pub. L. 92–463), the Centers for Disease 

Control and Prevention (CDC) 

announces the following meeting:

Name: Disease, Disability, and Injury 

Prevention and Control Special Emphasis 

Panel (SEP): Fetal Alcohol Syndrome 

Prevention and Surveillance in South AfricaDeveloping Community-Level Strategies that 

Work, RFA DD05–011. 

Times and Dates: 1 p.m.–1:35 p.m., 

January 11, 2005 (Open), 1:50 p.m.–4:30 

p.m., January 11, 2005 (Closed). 

Place: Teleconference Number: USA Toll 

Free 888–769–8515 Passcode 42438.