Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number 418116 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: August 28, 2014 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

SUBJECT: Dimethenamid/Dimethenamid-P. Acute and Chronic Aggregate Dietary (Food 

and Drinking Water) Exposure and Risk Assessments for Proposed New Use on 

Cottonseed Subgroup 20C. 

PC Code: 12905l/12005 1 

Decision No.: 482296 

Petition No.: 3F8197 

Risk Assessment Type: Dietary 

TXR No.: Not Applicable 

MRID No.: Not Applicable 

DP Barcode: D418116 

Registration No.: 7969-156 

Regulatory Action: Amended Section 3 Registration 

Case No.: 7223 

CAS No.: 87674-68-8/163515-14-8 

40 CFR: § 180.464 

FROM: Bonnie Cropp-Kohlligian, Environmental Scientis~~ (',_ ...,...._ ~ ;~ Risk Assessment Branch IV (RABIV) '-"'\\"" (J 

. . Health Effects Division (HED) (7509r:h/J 1/vJ r 

THROUGHf'Susan V. Hummel, Senior Chemist( }'J6--J. !J11t. 

RABIV

and 

, HED (7509P) ~ 

Thurston Morton, Senior Chemist 

David Hrdy, Senior Biologist ().It, 

Dietary Exposure Science Adv~~ 

TO: E. Kraft/K. Davis (RM 25) 

Herbicide Branch 

Registration Division (7505P) 

Executive Summary 

SAC), HED (7509P) 

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses 

were conducted in support of a human health risk assessment for the proposed Section 3 use of 

Page 1 of 13 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116 

dimethenamid-P on cottonseed subgroup 20C. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 

Both the acute and chronic assessments are conservative and incorporated tolerance level 

residues, assume 100% crop treated and use default processing factors. Estimated drinking water 

concentrations (EDWCs) used in the assessments were generated using Tier I modeling. 

For the acute assessment, aggregate dietary (food and drinking water) exposures are below 

HED's level of concern (<100% aPAD) at the 95th percentile of exposure for all population 

subgroups. The acute dietary exposure at the 95th percentile of exposure is estimated at 0.008399 

mg/kg/day for the overall U.S. population, equivalent to <1% of the aPAD. The population 

subgroup with the highest estimated acute dietary exposure is All Infants <1 year of age, with an 

estimated exposure at the 951

h percentile of 0.026253 mg/kg/day, equivalent to 1.3% ofthe 

aPAD. 

For the chronic assessment, aggregate dietary (food and drinking water) exposures are below 

HED's level of concern (<100% cPAD) for all population subgroups. The chronic dietary 

exposure is estimated at 0.003241 mg/kg/day for the general U.S. population, equivalent to 6.5% 

ofthe cPAD. The population subgroup with the highest estimated chronic dietary exposure is 

All Infants <1 year of age, with an estimated exposure of 0.008326 mg/kg/day, equivalent to 

17% of the cPAD. 

Dimethenamid is classified as a Group C chemical (possible human carcinogen). Cancer dietary 

risk concerns due to long-term consumption of dimethenamid residues are adequately addressed 

by the chronic dietary exposure analysis using the reference dose; therefore, a separate cancer 

dietary exposure analysis was not performed. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 1 00% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/606l.pdf; or see SOP 99.6 (20-AUG1999). 

The most recent dietary risk assessment for dimethenamid/dimethenamid-P was conducted by 

Breann Hanson (9/26/07, D341975). 

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Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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II. Residue Information

Dimethenamid is an equal part mixture of the S- and R-isomers (50:50, S:R); whereas, 

dimethenamid-P is enriched in the biologically active S-isomer (90:10, S:R). 

Hereafter in this document, both mixtures may be referred to as dimethenamid and 

references to dimethenamid should be understood to also apply to dimethenamid-P.

Plants: For the purposes of existing/proposes uses, the nature of the residue in plants is 

adequately understood based on available soybean, corn and sugar beet metabolism studies. The 

residue of concern for purposes of the tolerance expression and risk assessment is parent only. 

Tolerances are currently established under 40 CFR §180.464 (a) and (c) for residues of 

dimethenamid, 1(RS)-2-chloro-N-[(1-methyl-2-methoxy)ethyl]-N-(2,4-dimethylthien-3-

yl)acetamide, applied as either the 90:10 or 50:50 S:R isomers in/on numerous crop commodities 

ranging from 0.01 ppm to 2.5 ppm. Now, under PP#3F8197, HED is recommending in favor of 

establishing tolerances in/on cottonseed subgroup 20C and cotton, gin byproducts at 0.01 ppm 

and 1.5 ppm, respectively. The enforcement/data-collection methods are not enantiomer 

specific.

The current dietary analyses are based on the established/recommended tolerances for 

residues of dimethenamid in/on the food crops/commodities which are listed below in 

Table 1. These tolerances would apply to dimethenamid and/or dimethenamid-P. 

[Note: Livestock feed crops/commodities are excluded from this list.]

Table 1. Residue Summary for Dimethenamid/Dimethenamid-P excluding Livestock Feed Crops/Commodities.

Commodity

Established

Tolerance

(ppm)

Recommended 

Tolerance(s) 

Under Current 

Petition

(ppm)

Comments

Bean, dry, seed 0.01 --

Beet, garden, roots 0.01 --

Beet, garden, tops 0.01 --

Beet, sugar, molasses 0.01 --

Beet, sugar, roots 0.01 --

Beet, sugar, tops 0.01 --

Corn, field, grain 0.01 --

Corn, pop, grain 0.01 --

Corn, sweet, kernel plus cob 

w/husks removed

0.01 --

Cottonseed subgroup 20C -- 0.01 Crops in this subgroup include: cottonseed; 

cultivars, varieties, and/or hybrids of these.

Garlic 0.01 -- Under §180.1(g) this tolerance also applies to 

great headed garlic and serpent garlic.

Hops, dried cones 0.05 --

Horseradish 0.01 --

Leek 0.01 --

Onion, bulb 0.01 -- Under §180.1(g) this tolerance also applies to 

garlic; great headed garlic; serpent garlic; 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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Table 1. Residue Summary for Dimethenamid/Dimethenamid-P excluding Livestock Feed Crops/Commodities.

Commodity

Established

Tolerance

(ppm)

Recommended 

Tolerance(s) 

Under Current 

Petition

(ppm)

Comments

Chinese onion; pearl onion; potato onion; and 

shallot, bulb.

Onion, green 0.01 -- Under §180.1(g) this tolerance also applies to 

lady's leek; leek; wild leek; Beltsville bunching 

onion; fresh onion; tree onion, tops; Welsh 

onion; and shallot, fresh leaves.

Onion, Welsh 0.01 --

Peanut 0.01 --

Pumpkin 0.01 -- Tolerance with regional restriction established 

under 40 CFR 180.464(c).

Radish, roots 0.01 --

Radish, tops 0.01 --

Rutabaga, roots 0.01 --

Rutabaga, tops 0.1 --

Shallot, bulb 0.01 --

Shallot, fresh leaves 0.01 --

Squash, winter 0.01 -- Tolerance with regional restriction established 

under 40 CFR 180.464(c).

Sorghum, grain, grain 0.01 -- Under §180.1(g) this tolerance also applies to 

Sorghum spp. [sorghum, grain, sudangrass 

(seed crop), and hybrids of these grown for its 

seed].

Soybean, seed 0.01 --

Turnip, greens 0.1 -- Under §180.1(g) this tolerance also applies to 

broccoli raab (raab, raab salad), hanover salad, 

turnip tops (turnip greens).

Turnip, roots 0.01 --

Turnip, tops 0.1 --

Vegetable, tuberous and corm, 

subgroup 1C

0.01 -- Crops in this subgroup include: arracacha; 

arrowroot; artichoke, Chinese; artichoke, 

Jerusalem; canna, edible; cassava, bitter and 

sweet; chayote (root); chufa; dasheen; ginger; 

leren; potato; sweet potato; tanier; turmeric; 

yam bean; yam, true.

Livestock: HED has determined that there is no reasonable expectation of finite residues of 

concern in livestock commodities (40 CFR §180.6(a)(3)).

Drinking Water: In laboratory studies, two degradates of significance, dimethenamid oxanilic 

acid (M23; also referred to as the dimethenamid-OA degradate) and dimethenamid 

ethanesulfonic acid (M27; also referred to as the dimethenamid-ESA degradate) were formed 

through aerobic soil metabolism at up to 14.8% and 9% of the applied radioactivity, respectively. 

Three other major degradates, the dechlorinated parent (M3), the methyl sulfone derivative of 

M3 (M10) and the methyl sulfoxide derivative of M3 (M13), were formed through anaerobic 

aquatic metabolism at levels up to 20.6%, 9.8%, and 12.4% of the applied radioactivity, 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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respectively. Although M3, M10, and M13 are major degradates, they are formed only through 

anaerobic aquatic metabolism, which is not a major pathway for drinking water exposure. 

USGS National Water-Quality Assessment (NAWQA) Program Data conducted monitoring for 

dimethenamid and its degradates, dimethenamid-ESA and dimethenamid-OA, in surface, treated 

and ground waters. Dimethenamid was detected in surface water and treated water but not in 

groundwater. The dimethenamid-ESA and dimethenamid-OA degradates were detected in 

surface water and groundwater but not treated water. In ground water, the degradates were 

detected at higher concentrations and frequencies of detection than dimethenamid.

USDA PDP (2008-2012) also conducted monitoring for dimethenamid and its degradates,

dimethenamid-ESA and dimethenamid-OA, in untreated, treated and ground waters. 

Dimethenamid and the degradates were detected. As with the USGS NAWQA monitoring data, 

the degradates were detected in groundwater at higher concentrations and frequencies of 

detection than dimethenamid.

In previous risk assessment only the parent was considered a residue of concern in drinking 

water; however, the current risk assessment team has determined that the residues of concern in 

drinking water are dimethenamid and its degradates, dimethenamid ethanesulfonic acid 

(dimethenamid-ESA) and dimethenamid oxanilic acid (dimethenamid-OA). Although the 

degradates appear to be less toxic than parent (email from R. Kent to B. Cropp-Kohlligian dated 

5/22/14), they are included as residues of concern since they were identified as potentially 

significant degradates in the available fate data and found in greater abundance than the parent in 

some of the water monitoring studies.

Fish: No tolerances are currently established for residues of dimethenamid or dimethenamid-P 

in fish. The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 

2008, 2009, and 2010. Over this 3-year period, PDP analyzed 1479 samples of catfish for

dimethenamid residues. None of the samples contained detectable residues of dimethenamid. 

As a result, residues in fish were not included in the assessment.

III. Percent Crop Treated Information

The acute and chronic assessments are based on the assumption that 100% of all commodities 

with tolerances will be treated.
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in a drinking water assessment (DWA; 

D422167, M. Biscoe, 8/14/14) entitled: “Dimethenamid-P: ADDENDUM Drinking Water 

Exposure Assessment for Existing Ornamental and Green Onion Uses and the Proposed Cotton 

Use.” Estimated Drinking Water Concentrations (EDWCs) for dimethenamid were calculated 

for the parent compound plus the dimethenamid ethanesulfonic acid (dimethenamid-ESA) and 

dimethenamid oxanilic acid (dimethenamid-OA) degradates. These estimated drinking water 

concentrations (EDWCs) were incorporated directly into this dietary assessment in the DEEMFCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” 

EFED generated the surface water EDWCs using the Surface Water Concentration Calculator 

(SWCC) and groundwater EDWCs were generated using Pesticide Root Zone Model for Ground 

Water (PRZM-GW). EDWCs were derived based on the maximum registered use rate 

(ornamentals 3.0 lb ai/A), the maximum use rate on green onion (i.e., the scenario that resulted in 

the highest EDWCs in prior DWA) and the proposed use on cotton (1.45 lb ai/A). 

The maximum EDWCs calculated in this assessment are shown in Table 2. In surface water, the 

highest estimated peak (acute) concentration is 73 μg/L, the highest estimated 1-in-10 year 

annual average concentration is 27 μg/L, and the highest estimated 30-year annual average 

concentration is 16 μg/L. In groundwater, the estimated peak (acute) concentration is 153 μg/L, 

and the estimated post-breakthrough average (chronic) concentration is 140 μg/L. Because the 

maximum acute (groundwater 153 μg/L) and chronic (groundwater 140 μg/L) EDWCs were so 

close, the maximum EDWC in groundwater, 153 μg/L, was used in both the acute and chronic 

dietary assessments to estimate residues in drinking water.

Table 2. Maximum estimated drinking water concentrations (EDWCs) in parts per billion (μg/L) for 

dimethenamid and its degradates, dimethenamid-ESA and dimethenamid-OA, for use in the dietary risk 

assessments.

Drinking Water 

Source (model)

[Tier]

Model Scenario & 

Application Method

Acute Chronic Cancer

μg/L

Surface Water

(SWCC) [Tier 2]

New Jersey Nursery 

(Ornamentals)

Ground Application

Peak

1-in-10 Year

Chronic

1-in-10 Year

30-year Annual 

Average

73 27 16

Groundwater 

(PRZM-GW 30-year 

simulation) [Tier 1]

Wisconsin Corn

(Ornamentals)

Peak Post-Breakthrough Average

153 140

The drinking water models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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V. DEEM-FCID Program and Consumption Information

Dimethenamid and dimethenamid-P acute and chronic dietary exposure assessments were 

conducted using the DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption 

data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of 

more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; 

fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups. 

However, for acute exposure assessment, consumption data are retained as individual 

consumption events. Based on analysis of the 2003-2008 WWEIA consumption data, which 

took into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. population, all 

infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, 

females 13-49, and adults 50-99 years old.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

VI. Toxicological Information

HED evaluated the toxicology data base for dimethenamid and dimethenamid-P and selected 

doses and endpoints for dietary risk assessments provided in Table 3. Details are discussed in 

the forthcoming risk assessment (D418118).
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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Table 3. Summary of Toxicological Doses and Endpoints for Use in Human Health Risk Assessments

Exposure/

Scenario

Point of 

Departure

(mg/kg/day)

Safety Factors

POD for 

Risk 

Assessment 

(mg/kg/day)

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including Infants 

and Children)

NOAEL = 200

UFA= 10x

UFH=10x

FQPA SF= 1x

aRfD = 2.0

aPAD = 2.0

LOAEL= 600 mg/kg from ACN study 

based on lacrimation, salivation, irregular 

and accelerated respiration, slight tremors, 

reduced exploration, unsteady gait, 

significantly reduced rearing (females) and 

strongly constricted pupils (males)

Acute Dietary

(Females 13-49 

years of age)

NOAEL = 75

UFA= 10x

UFH=10x

FQPA SF= 1x

aRfD = 0.75

aPAD = 0.75

Developmental toxicity study in rabbits

Maternal; LOAEL = 150 mg/kg/day based 

on abortions and decreased body weight 

gain and food consumption.

Developmental; LOAEL = 150 mg/kg/day 

based on post-implantation loss

Chronic Dietary 

(All Populations) NOAEL= 5 

UFA= 10x

UFH=10x

FQPA SF= 1x

cRfD = 0.05

cPAD = 0.05

Chronic/carcinogenicity study in rats

LOAEL = M/F; 36/49 mg/kg/day based on 

decreased body weight and body weight 

gain in both sexes, increased food 

conversion ratios in females, and increased 

microscopic hepatic lesions in both sexes.

Cancer (oral, 

dermal, inhalation)

“C” Possible human carcinogen. The cRfD is considered protective of the cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). UFL = use of a LOAEL to extrapolate a 

NOAEL. UFS = use of a short-term study for long-term risk assessment. UFDB = to account for the absence of key 

data (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c 

= chronic). RfD = reference dose. MOE = margin of exposure. LOC = level of concern. N/A = not applicable.

II. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various subgroups including the general U.S. population, all infants (<1 year old), 

children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 

50-99 years old. The acute and chronic dietary exposure analyses are reported in Table 4.

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Dimethenamid/Dimethenamid-P.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.008399 <1 0.003241 6.5

N/A

All Infants (<1 year old) 0.026253 1.3 0.008326 17

Children 1-2 years old 0.013042 <1 0.004710 9.4

Children 3-5 years old 0.010635 <1 0.003980 8.0
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Dimethenamid/Dimethenamid-P.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

Children 6-12 years old 0.008023 <1 0.002868 5.7

Youth 13-19 years old 0.006982 <1 0.002373 4.7

Adults 20-49 years old 0.008253 <1 0.003228 6.5

Adults 50-99 years old 0.007364 <1 0.003186 6.4

Females 13-49 years old 0.008361 1.1 0.003214 6.4

VIII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure and risk analyses are based on tolerance-level residues, 

100% crop treated assumptions, and default processing factors. Various refinements could be 

made to the assessments. However, as there are no risk estimates of concern, no refinements 

were incorporated.

IX. Conclusions

Conservative acute and chronic dietary (food and drinking water) exposure analyses were 

performed for the general U.S. population and various population subgroups. The acute and 

chronic risk estimates are not of concern. HED is confident the acute and chronic dietary 

exposures to dimethenamid/dimethenamid-P are not underestimated.

For the acute assessment, aggregate dietary (food and drinking water) exposures are below 

HED’s level of concern (<100% aPAD) at the 95

th percentile of exposure for all population 

subgroups. The acute dietary exposure at the 95

th percentile of exposure is estimated at 0.008399

mg/kg/day for the overall U.S. population, equivalent to <1% of the aPAD. The population 

subgroup with the highest estimated acute dietary exposure is All Infants <1 year of age, with an 

estimated exposure at the 95

th percentile of 0.026253 mg/kg/day, equivalent to 1.3% of the 

aPAD. 

For the chronic assessment, aggregate dietary (food and drinking water) exposures are below 

HED’s level of concern (<100% cPAD) for all population subgroups. The chronic dietary 

exposure is estimated at 0.003241 mg/kg/day for the general U.S. population (6.5% of the cPAD) 

and 0.008326 mg/kg/day (17% of the cPAD) for All Infants <1 year of age, the population 

subgroup with the highest estimated chronic dietary exposure.

X. List of Attachments

Attachment 1. Acute/Chronic Residue Input File for Dimethenamid/Dimethenamid-P

Attachment 2. Summary of the Acute Dietary Exposure and Risk Estimates.

Attachment 3. Summary of the Chronic Dietary Exposure and Risk Estimates. 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

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Attachment 1. Acute/Chronic Residue Input File for Dimethenamid/Dimethenamid-P.

Filename: Dimethenamid 129051 and 120051.R08

Dimethenamid 129051 and 120051 Females 13 to 49.r08

Dimethenamid 129051 and 120051.R08

Chemical: Dimethenamid and Dimethenamid-P

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day

RfD(Acute All Populations except Females 13-49): 2 mg/kg bw/day NOEL(Acute): 200 mg/kg bw/day

RfD(Acute Females 13-49): 0.75 mg/kg bw/day NOEL(Acute): 75 mg/kg bw/day

Date created/last modified: 08-28-2014/12:27:32 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.010000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.010000 1.000 1.000 

0101052000 1A Beet, sugar 0.010000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.010000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.010000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.010000 1.000 1.000 

0101190000 1AB Horseradish 0.010000 1.000 1.000 

0101314000 1AB Radish, roots 0.010000 1.000 1.000 

0101327000 1AB Rutabaga 0.010000 1.000 1.000 

0101388000 1AB Turnip, roots 0.010000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.010000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 

0103082000 1CD Cassava 0.010000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.010000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 

0103166000 1CD Ginger 0.010000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.010000 1.000 1.000 

0103167000 1CD Ginger, dried 0.010000 1.000 1.000 

0103296000 1C Potato, chips 0.010000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.010000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.010000 6.500 1.000 

0103298000 1C Potato, flour 0.010000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.010000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

0103366000 1CD Sweet potato 0.010000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.010000 1.000 1.000 

0103371000 1CD Tanier, corm 0.010000 1.000 1.000 

0103387000 1CD Turmeric 0.010000 1.000 1.000 

0103406000 1CD Yam, true 0.010000 1.000 1.000 

0103407000 1CD Yam bean 0.010000 1.000 1.000 

0200051000 2 Beet, garden, tops 0.010000 1.000 1.000 

0200140000 2 Dasheen, leaves 0.010000 1.000 1.000 

0200315000 2 Radish, tops 0.010000 1.000 1.000 

0301165000 3A Garlic, bulb 0.010000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.010000 1.000 1.000 

0301237000 3A Onion, bulb 0.010000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.010000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.010000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.010000 9.000 1.000 

0301338000 3A Shallot, bulb 0.010000 1.000 1.000 

0302198000 3B Leek 0.010000 1.000 1.000 

0302239000 3B Onion, green 0.010000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 0.010000 1.000 1.000 

0502063000 5B Broccoli raab 0.100000 1.000 1.000 

0502389000 5B Turnip, greens 0.100000 1.000 1.000 

0600347000 6 Soybean, seed 0.010000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.010000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.000 

0600350000 6 Soybean, oil 0.010000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.010000 1.000 1.000 

0603030000 6C Bean, black, seed 0.010000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.010000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.010000 1.000 1.000 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

Page 11 of 13

0603035000 6C Bean, great northern, seed 0.010000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.010000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.010000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.010000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.010000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.010000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.010000 1.000 1.000 

0603098000 6C Chickpea, seed 0.010000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.010000 1.000 1.000 

0603099000 6C Chickpea, flour 0.010000 1.000 1.000 

0603182000 6C Guar, seed 0.010000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.010000 1.000 1.000 

0603203000 6C Lentil, seed 0.010000 1.000 1.000 

0603348000 6C Soybean, flour 0.010000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.010000 1.000 1.000 

0902308000 9B Pumpkin 0.010000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.010000 1.000 1.000 

0902357000 9B Squash, winter 0.010000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.010000 1.000 1.000 

1500120000 15 Corn, field, flour 0.010000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.010000 1.000 1.000 

1500121000 15 Corn, field, meal 0.010000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.010000 1.000 1.000 

1500122000 15 Corn, field, bran 0.010000 1.000 1.000 

1500123000 15 Corn, field, starch 0.010000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.010000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.010000 1.000 1.000 *

1500124001 15 Corn, field, syrup-babyfood 0.010000 1.000 1.000 *

1500125000 15 Corn, field, oil 0.010000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.010000 1.000 1.000 

1500126000 15 Corn, pop 0.010000 1.000 1.000 

1500127000 15 Corn, sweet 0.010000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

1500344000 15 Sorghum, grain 0.010000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.010000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.010000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.010000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.153000 1.000 1.000 **

8602000000 86B Water, indirect, all sources 0.153000 1.000 1.000 **

9500188000 O Hop 0.050000 1.000 1.000 

9500263000 O Peanut 0.010000 1.000 1.000 

9500264000 O Peanut, butter 0.010000 1.890 1.000 

9500265000 O Peanut, oil 0.010000 1.000 1.000 Filename: 

*In accordance with DESAC determination, DEEM default processing factor (1.5) is not needed.

**Because the maximum EDWC for acute (groundwater 153 μg/L) and chronic (groundwater 140 μg/L) 

are so close, 153 μg/L was used to estimate residues in drinking water for both the acute and 

chronic assessments.
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

Page 12 of 13

Attachment 2. Summary of Acute Dietary Exposure and Risk Estimates for Dimethenamid/Dimethenamid-P.

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DIMETHENAMID AND DIMETHENAMID-P

 NHANES 2003-2008 2-Day

Residue file: Dimethenamid 129051 and 120051.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-28-2014/12:31:12 Residue file dated: 08-28-2014/12:27:32

RfD(Acute All Populations except Females 13-49): 2 mg/kg bw/day NOEL(Acute): 200 mg/kg bw/day

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.008399 0.42 23812 0.013815 0.69 14476 0.026261 1.31 7615 

All Infants:

 0.026253 1.31 7618 0.035458 1.77 5640 0.051967 2.60 3848 

Children 1-2:

 0.013042 0.65 15335 0.019557 0.98 10226 0.047591 2.38 4202 

Children 3-5:

 0.010635 0.53 18806 0.016197 0.81 12347 0.025825 1.29 7744 

Children 6-12:

 0.008023 0.40 24926 0.013146 0.66 15214 0.020261 1.01 9870 

Youth 13-19:

 0.006982 0.35 28646 0.011490 0.57 17405 0.017318 0.87 11548 

Adults 20-49:

 0.008253 0.41 24234 0.012219 0.61 16367 0.017839 0.89 11211 

Adults 50-99:

 0.007364 0.37 27159 0.011121 0.56 17983 0.017559 0.88 11390 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DIMETHENAMID AND DIMETHENAMID-P

 NHANES 2003-2008 2-Day

Residue file: Dimethenamid 129051 and 120051 Females 13 to 49.r08

Adjustment factor #2 NOT used.

Analysis Date: 08-28-2014/12:32:24 Residue file dated: 08-28-2014/12:28:06

RfD(Acute Females 13-49): 0.75 mg/kg bw/day NOEL(Acute): 75 mg/kg bw/day

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

 0.008361 1.11 8970 0.012255 1.63 6119 0.017317 2.31 4330 
Dimethenamid/Dimethenamid-P Dietary Exposure and Risk Assessment DP Number: 418116

Page 13 of 13

Attachment 3. Summary of Chronic Dietary Exposure and Risk Estimates for DImethenamid/Dimethenamid-P. 

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for DIMETHENAMID AND DIMETHENAMID-P

 NHANES 2003-2008 2-day

Residue file name: Dimethenamid 129051 and 120051.R08

 Adjustment factor #2 NOT used.

Analysis Date 08-28-2014/12:34:40 Residue file dated: 08-28-2014/12:27:32

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.003241 6.5%

Hispanic 0.003101 6.2%

Non-Hisp-White 0.003331 6.7%

Non-Hisp-Black 0.002683 5.4%

Non-Hisp-Other 0.003732 7.5%

Nursing Infants 0.002930 5.9%

Non-Nursing Infants 0.010736 21.5%

Female 13+ PREG 0.003050 6.1%

Children 1-6 0.004189 8.4%

Children 7-12 0.002728 5.5%

Male 13-19 0.002243 4.5%

Female 13-19/NP 0.002501 5.0%

Male 20+ 0.003017 6.0%

Female 20+/NP 0.003392 6.8%

Seniors 55+ 0.003123 6.2%

All Infants 0.008326 16.7%

Female 13-50 0.003218 6.4%

Children 1-2 0.004710 9.4%

Children 3-5 0.003980 8.0%

Children 6-12 0.002868 5.7%

Youth 13-19 0.002373 4.7%

Adults 20-49 0.003228 6.5%

Adults 50-99 0.003186 6.4%

Female 13-49 0.003214 6.4%

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