Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 22779 

Operations, north of the town of 

Tonopah in Nye County, NV, Wait 

Period Ends: 05/25/2010, Contact: 

Christopher Worthington 775–635– 

4000 Revision to FR Notice Published 

04/26/2010: Correction to Wait Period 

End from 05/24/2010 to 05/25/2010. 

EIS No. 20100136, Final EIS, USFS, 00, 

Nebraska National Forests and 

Grassland Travel Management Project, 

Proposes to Designate Routes and 

Areas Open to Motorized Travel, 

Buffalo Gap National Grassland, 

Oglala National Grassland, Samuel R. 

McKelvie National Forest, and the 

Pine Ridge and Bessey Units of the 

Nebraska National Forest, Fall River, 

Custer, Pennington, Jackson Counties; 

SD and Sioux, Dawes, Cherry, 

Thomas and Blaine Counties, NE, 

Wait Period Ends: 05/25/2010, 

Contact: Mike McNeill 308–432–0336, 

Revision to FR Notice Published 04/ 

26/2010: Correction to Wait, Period 

End from 05/24/2010 to 05/25/2010. 

EIS No. 20100137, Draft EIS, USFS, ID, 

Robo Elk Project, Proposes Watershed 

Improvement, Timber Harvest, Fuel 

Treatments, and Recreation Activities, 

Palouse Ranger District, Clearwater 

National Forest, Clearwater County, 

ID, Comment Period Ends: 06/09/ 

2010, Contact: George Harbaugh 208– 

935–4260, Revision to FR Notice 

Published 04/26/2010: Correction to 

Comment Period End from 06/07/ 

2010 to 06/09/2010. 

EIS No. 20100138, Final EIS, BR, CA, 

Lake Casitas Resource Management 

Plan (RMP), Implementation, Cities of 

Los Angeles and Ventura, Western 

Ventura County, CA, Wait Period 

Ends: 05/25/2010, Contact: Jack 

Collins 559–349–4544, Revision to FR 

Notice Published 04/26/2010: 

Correction to Wait, Period End from 

05/24/2010 to 05/25/2010. 

EIS No. 20100139, Draft EIS, USFS, CA, 

Kelsey Peak Timber Sale and 

Fuelbreak Project, Proposing to 

Harvest Commercial Timber and 

Create Fuelbreak, Upper Mad River 

Watershed, Mad River Ranger District, 

Six Rivers National Forest, Trinity 

County, CA, Comment Period Ends: 

06/09/2010, Contact: Keith Menasco 

928–774–0594, Revision to FR Notice 

Published 04/26/2010: Correction to 

Comment Period End from 06/07/ 

2010 to 06/09/2010. 

EIS No. 20100140, Final EIS, FSA, 00, 

WITHDRAWN—PROGRAMMATIC— 

Biomass Crop Assistance Program 

(BCAP), To Establish and Administer 

the Program Areas Program 

Component of BCAP as mandated in 

Title IX of the 2008 Farm Bill in the 

United States, Wait Period Ends: 05/ 

25/2010, Contact: Matthew T. Ponish 

202–720–6853, Revision to FR Notice 

Published 04/26/2010: Officially 

Withdrawn by the preparing agency 

by letter dated 04/26/2010. 

EIS No. 20100141, Final EIS, BLM, UT, 

Mona to Oquirrh Transmission 

Corridor Project and Draft Pony 

Express Resource Management Plan 

Amendment, Construction, Operation, 

Maintenance and Decommissioning a 

Double-Circuit 500/345 Kilovolt (Kv) 

Transmission Line, Right-of-Way 

Grant, Rocky Mountain Power, Juab, 

Salt Lake, Tooele and Utah Counties, 

UT, Wait Period Ends: 05/25/2010, 

Contact: Mike Nelson 801–977–4300, 

Revision to FR Notice Published 04/ 

26/2010: Correction to Wait, Period 

End from 05/24/2010 to 05/25/2010. 

EIS No. 20100142, Draft EIS, USFS, UT, 

Kitty Hawk Administrative Site 

Master Development Plan, 

Implementation, Cedar City Ranger 

District, Dixie National Forest, Cedar 

City, Iron County, UT, Comment 

Period Ends: 06/09/2010, Contact: 

Georgina Lampman 435–865–3794, 

Revision to FR Notice Published 04/ 

26/2010: Correction to Comment 

Period End from 06/07/2010 to 06/09/ 

2010. 

EIS No. 20100143, Final EIS, FHWA, 

NC, NC–24 Transportation 

Improvements, from west of I–95 to I– 

40, Funding, US Army COE 4040 

Permit, Cumberland, Sampson, and 

Duplin Counties, NC, Wait Period 

Ends: 05/25/2010, Contact: John F. 

Sullivan 919–865–4346, Revision to 

FR Notice Published 04/26/2010: 

Correction to Wait, Period End from 

05/24/2010 to 05/25/2010. 

EIS No. 20100144, Draft EIS, NRC, SC, 

Virgil C. Summer Nuclear Station 

Units 2 and 3, Application for 

Combined License to Construct and 

Operate a New Nuclear Reactors, 

Fairfield County, SC, Comment Period 

Ends: 07/09/2010, Contact: Patricia 

Vokoun 301–415–3470, Revision to 

FR Notice Published 04/26/2010: 

Correction to Comment Period End 

from 07/06/2010 to 07/09/2010. 

EIS No. 20100145, Draft EIS, NRC, MD, 

Calvert Cliffs Nuclear Power Plant 

Unit 3, Application for Combined 

License for Construct and Operate a 

New Nuclear Unit, NUREG 1936, 

Calvert County, MD, Comment Period 

Ends: 07/09/2010, Contact: Laura 

Quinn 301–415–2220, Revision to FR 

Notice Published 04/26/2010: 

Correction to Comment Period End 

from 07/06/2010 to 07/09/2010. 

Dated: April 27, 2010. 

Robert W. Hargrove, 

Director, NEPA Compliance Division, Office 

of Federal Activities. 

[FR Doc. 2010–10156 Filed 4–29–10; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2010–0383; FRL–8823–8] 

FIFRA Scientific Advisory Panel; 

Notice of Public Meeting 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: There will be a 3–day 

meeting of the Federal Insecticide, 

Fungicide, and Rodenticide Act 

Scientific Advisory Panel (FIFRA SAP) 

to consider and review a set of scientific 

issues related to review of SHEDsMultimedia version 4, Peer consult on 

PBPK Modeling, and a SHEDS-PBPK 

Permethrin study. 

DATES: The meeting will be held on July 

20-22, 2010, from 9 a.m. to 

approximately 5:30 p.m. 

Comments. The Agency encourages 

that written comments be submitted by 

July 8, 2010 and requests for oral 

comments be submitted by July 15, 

2010. However, written comments and 

requests to make oral comments may be 

submitted until the date of the meeting, 

but anyone submitting written 

comments after July 8, 2010 should 

contact the Designated Federal Official 

(DFO) listed under FOR FURTHER

INFORMATION CONTACT. For additional 

instructions, see Unit I.C. of the 

SUPPLEMENTARY INFORMATION. 

Nominations. Nominations of 

candidates to serve as ad hoc members 

of FIFRA SAP for this meeting should 

be provided on or before May 14, 2010. 

Webcasting. This meeting may be 

webcast. Please refer to the FIFRA SAP’s 

website, http://www.epa.gov/scipoly/ 

SAP/ for information on how to access 

the webcast. Please note that the 

webcast is a supplementary public 

process provided only for convenience. 

If difficulties arise resulting in 

webcasting outages, the meeting will 

continue as planned. 

Special accommodations. For 

information on access or services for 

individuals with disabilities, and to 

request accommodation of a disability, 

please contact the DFO listed under FOR

FURTHER INFORMATION CONTACT at least 

10 days prior to the meeting to give EPA 

as much time as possible to process 

your request. 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1
22780 Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 

ADDRESSES: The meeting will be held at 

the Environmental Protection Agency, 

Conference Center, Lobby Level, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA 22202. 

Comments. Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPP–2010–0383, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001. 

• Delivery: OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S–4400, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket 

Facility’s normal hours of operation 

(8:30 a.m. to 4 p.m., Monday through 

Friday, excluding legal holidays). 

Special arrangements should be made 

for deliveries of boxed information. The 

Docket Facility telephone number is 

(703) 305–5805. 

Instructions. Direct your comments to 

docket ID number EPA–HQ–OPP–2010– 

0383. If your comments contain any 

information that you consider to be CBI 

or otherwise protected, please contact 

the DFO listed under FOR FURTHER

INFORMATION CONTACT to obtain special 

instructions before submitting your 

comments. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov website is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD-ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

is not placed on the Internet and will be 

publicly available only in hard copy 

form. Publicly available docket 

materials are available either in the 

electronic docket at http:// 

www.regulations.gov, or, if only 

available in hard copy, at the OPP 

Regulatory Public Docket in Rm. S– 

4400, One Potomac Yard (South Bldg.), 

2777 S. Crystal Dr., Arlington, VA. The 

hours of operation of this Docket 

Facility are from 8:30 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305–5805. 

Nominations, requests to present oral 

comments, and requests for special 

accommodations. Submit nominations 

to serve as ad hoc members of FIFRA 

SAP, requests for special seating 

accommodations, or requests to present 

oral comments to the DFO listed under 

FOR FURTHER INFORMATION CONTACT. 

FOR FURTHER INFORMATION CONTACT: 

Sharlene R. Matten, DFO, Office of 

Science Coordination and Policy 

(7201M), Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001; telephone 

number: (202) 564–0130; fax number: 

(202) 564–8382; e-mail address: 

matten.sharlene@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this Action Apply to Me? 

This action is directed to the public 

in general. This action may, however, be 

of interest to persons who are or may be 

required to conduct testing of chemical 

substances under the Federal Food, 

Drug, and Cosmetic Act (FFDCA), 

FIFRA, and the Food Quality Protection 

Act of 1996 (FQPA). Since other entities 

may also be interested, the Agency has 

not attempted to describe all the specific 

entities that may be affected by this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the DFO 

listed under FOR FURTHER INFORMATION

CONTACT. 

B. What Should I Consider as I Prepare 

My Comments for EPA? 

When submitting comments, 

remember to: 

1. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

2. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

3. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

4. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

5. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

6. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

7. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

8. Make sure to submit your 

comments by the comment period 

deadline identified. 

C. How May I Participate in this 

Meeting? 

You may participate in this meeting 

by following the instructions in this 

unit. To ensure proper receipt by EPA, 

it is imperative that you identify docket 

ID number EPA–HQ–OPP–2010–0383 in 

the subject line on the first page of your 

request. 

1. Written comments. The Agency 

encourages that written comments be 

submitted, using the instructions in 

ADDRESSES, no later than July 8, 2010, to 

provide FIFRA SAP the time necessary 

to consider and review the written 

comments. Written comments are 

accepted until the date of the meeting, 

but anyone submitting written 

comments after July 15, 2010 should 

contact the DFO listed under FOR

FURTHER INFORMATION CONTACT. Anyone 

submitting written comments at the 

meeting should bring 30 copies for 

distribution to FIFRA SAP. 

2. Oral comments. The Agency 

encourages that each individual or 

group wishing to make brief oral 

comments to FIFRA SAP submit their 

request to the DFO listed under FOR

FURTHER INFORMATION CONTACT no later 

than July 15, 2010, in order to be 

included on the meeting agenda. 

Requests to present oral comments will 

be accepted until the date of the meeting 

and, to the extent that time permits, the 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1
Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 22781 

Chair of FIFRA SAP may permit the 

presentation of oral comments at the 

meeting by interested persons who have 

not previously requested time. The 

request should identify the name of the 

individual making the presentation, the 

organization (if any) the individual will 

represent, and any requirements for 

audiovisual equipment (e.g., overhead 

projector, 35 mm projector, chalkboard). 

Oral comments before FIFRA SAP are 

limited to approximately 5 minutes 

unless prior arrangements have been 

made. In addition, each speaker should 

bring 30 copies of his or her comments 

and presentation slides for distribution 

to the FIFRA SAP at the meeting. 

3. Seating at the meeting. Seating at 

the meeting will be open and on a firstcome basis. 

4. Request for nominations to serve as 

ad hoc members of FIFRA SAP for this 

meeting. As part of a broader process for 

developing a pool of candidates for each 

meeting, FIFRA SAP staff routinely 

solicits the stakeholder community for 

nominations of prospective candidates 

for service as ad hoc members of FIFRA 

SAP. Any interested person or 

organization may nominate qualified 

individuals to be considered as 

prospective candidates for a specific 

meeting. Individuals nominated for this 

meeting should have expertise in one or 

more of the following areas: pesticide 

exposure, general statistics, exposure 

modeling, dose modeling, and risk 

assessment. Nominees should be 

scientists who have sufficient 

professional qualifications, including 

training and experience, to be capable of 

providing expert comments on the 

scientific issues for this meeting. 

Nominees should be identified by name, 

occupation, position, address, and 

telephone number. Nominations should 

be provided to the DFO listed under FOR

FURTHER INFORMATION CONTACT on or 

before May 14, 2010. The Agency will 

consider all nominations of prospective 

candidates for this meeting that are 

received on or before this date. 

However, final selection of ad hoc 

members for this meeting is a 

discretionary function of the Agency. 

The selection of scientists to serve on 

FIFRA SAP is based on the function of 

the panel and the expertise needed to 

address the Agency’s charge to the 

panel. No interested scientists shall be 

ineligible to serve by reason of their 

membership on any other advisory 

committee to a Federal department or 

agency or their employment by a 

Federal department or agency except the 

EPA. Other factors considered during 

the selection process include 

availability of the potential panel 

member to fully participate in the 

panel’s reviews, absence of any conflicts 

of interest or appearance of lack of 

impartiality, independence with respect 

to the matters under review, and lack of 

bias. Although financial conflicts of 

interest, the appearance of lack of 

impartiality, lack of independence, and 

bias may result in disqualification, the 

absence of such concerns does not 

assure that a candidate will be selected 

to serve on FIFRA SAP. Numerous 

qualified candidates are identified for 

each panel. Therefore, selection 

decisions involve carefully weighing a 

number of factors including the 

candidates’ areas of expertise and 

professional qualifications and 

achieving an overall balance of different 

scientific perspectives on the panel. In 

order to have the collective breadth of 

experience needed to address the 

Agency’s charge for this meeting, the 

Agency anticipates selecting 

approximately 12–15 ad hoc scientists. 

FIFRA SAP members are subject to 

the provisions of 5 CFR part 2634, 

Executive Branch Financial Disclosure, 

as supplemented by the EPA in 5 CFR 

part 6401. In anticipation of this 

requirement, prospective candidates for 

service on the FIFRA SAP will be asked 

to submit confidential financial 

information which shall fully disclose, 

among other financial interests, the 

candidate’s employment, stocks and 

bonds, and where applicable, sources of 

research support. The EPA will evaluate 

the candidates financial disclosure form 

to assess whether there are financial 

conflicts of interest, appearance of a 

lack of impartiality or any prior 

involvement with the development of 

the documents under consideration 

(including previous scientific peer 

review) before the candidate is 

considered further for service on FIFRA 

SAP. Those who are selected from the 

pool of prospective candidates will be 

asked to attend the public meetings and 

to participate in the discussion of key 

issues and assumptions at these 

meetings. In addition, they will be asked 

to review and to help finalize the 

meeting minutes. The list of FIFRA SAP 

members participating at this meeting 

will be posted on the FIFRA SAP 

website at http://epa.gov/scipoly/sap or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

II. Background 

A. Purpose of FIFRA SAP 

FIFRA SAP serves as the primary 

scientific peer review mechanism of 

EPA’s Office of Chemical Safety and 

Pollution Prevention (OCSPP) and is 

structured to provide scientific advice, 

information and recommendations to 

the EPA Administrator on pesticides 

and pesticide-related issues as to the 

impact of regulatory actions on health 

and the environment. FIFRA SAP is a 

Federal advisory committee established 

in 1975 under FIFRA that operates in 

accordance with requirements of the 

Federal Advisory Committee Act. FIFRA 

SAP is composed of a permanent panel 

consisting of seven members who are 

appointed by the EPA Administrator 

from nominees provided by the National 

Institutes of Health and the National 

Science Foundation. FIFRA, as 

amended by FQPA, established a 

Science Review Board consisting of at 

least 60 scientists who are available to 

the SAP on an ad hoc basis to assist in 

reviews conducted by the SAP. As a 

peer review mechanism, FIFRA SAP 

provides comments, evaluations and 

recommendations to improve the 

effectiveness and quality of analyses 

made by Agency scientists. Members of 

FIFRA SAP are scientists who have 

sufficient professional qualifications, 

including training and experience, to 

provide expert advice and 

recommendation to the Agency. 

B. Public Meeting 

The Food Quality Protection Act 

(FQPA) amended laws under which 

EPA evaluates the safety of pesticide 

residues in food. Section 408(b)(2)(D)(v) 

and (vi) of the Federal Food, Drug, and 

Cosmetic Act (FFDCA) as amended by 

FQPA, specifies that, when determining 

the safety of a pesticide chemical, EPA 

shall consider aggregate exposure 

(i.e.,total dietary (food and water), 

residential, and other nonoccupational) and available information 

concerning the cumulative effects to 

human health that may result from 

exposure to other substances that have 

a common mechanism of toxicity. 

Aggregate assessments account for 

multiple sources and routes of exposure 

for a single chemical. FQPA-mandated 

cumulative assessments combine 

exposures and doses to two or more 

chemicals that share a common 

mechanism of toxicity. 

EPA’s Office of Pesticide Programs 

(OPP) and Office of Research and 

Development (ORD) have been 

conducting collaborative science to 

inform the Agency’s anticipated 

pyrethroid cumulative risk assessment 

(CRA). This FIFRA SAP review is part 

of the Agency’s ongoing process to 

enhance probabilistic exposure, dose, 

and risk assessments, and OPP’s 

ongoing efforts to consider available 

probabilistic exposure and dose models 

to address FQPA. Through a 

coordinated multi-disciplinary effort, 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1
22782 Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 

ORD and OPP scientists have developed 

new approaches for Commulative Risk 

Assessment (CRA) which are 

incorporated into ORD’s SHEDSMultimedia (Stochastic Human 

Exposure and Dose Simulation) 

computer model and software. SHEDSMultimedia (http://www.epa.gov/heasd/ 

products/ shedslmultimedia/ 

shedslmm.html) is a physically-based, 

probabilistic model that predicts for 

user-specified population cohorts 

exposures incurred via eating 

contaminated foods or drinking water, 

inhaling contaminated air, touching 

contaminated surface residues, and 

ingesting residues from hand-to-mouth 

or object-to-mouth activities. It can 

simulate aggregate or cumulative 

exposures over time via multiple routes 

of exposure (dietary & non-dietary 

residential) for multiple types of 

chemicals & scenarios. To do this, it 

combines information on chemical 

usage, human activity data (e.g., from 

Consolidated Human Activity Database 

(CHAD; www.epa.gov/chadnet1) time/ 

activity diary surveys and videography 

studies), environmental residues and 

concentrations, and exposure factors to 

generate time series of exposure for 

simulated individuals. One-stage or 

two-stage Monte Carlo simulation is 

used to produce distributions of 

exposure for various population cohorts 

(e.g., age/gender groups) that reflect the 

variability and/or uncertainty in the 

input parameters. 

While the core of SHEDS-Multimedia 

is the concentration-to-exposure 

module, there are various options (e.g., 

built-in simple source-to-concentration 

module, user-entered time series from 

other models or field study 

measurements) for obtaining 

concentration inputs. SHEDSMultimedia also includes a simple builtin pharmacokinetic (PK) model. In 

addition, SHEDS-Multimedia exposure 

outputs can be used as inputs to more 

sophisticated physiologically-based 

pharmacokinetic (PBPK) models which 

can, in turn, be used to model and 

estimate tissue burden and urinary 

concentrations of chemicals through 

class-oriented approaches. The 

combined exposure- and dose- modeled 

outputs will be compared against realworld biomonitoring data, and will be 

integrated with corresponding effects 

research. 

An earlier version of the SHEDSMultimedia model (version 3) was 

originally presented to the SAP for 

review in August 2007 (http:// 

www.epa.gov/scipoly/SAP/meetings/ 

2007/081407lmtg.htm). In that version, 

only the aggregate residential module of 

SHEDS-Multimedia was operational, 

and then only for post-application 

exposures (i.e., pesticide applicators 

were not considered). In that 2007 

meeting, the SAP reviewed the aggregate 

residential (post-application only) 

version of SHEDS-Multimedia (version 

3), as well as conceptual plans for the 

SHEDS dietary module and for the 

PBPK modeling. 

This July 2010 SAP will focus on 

work conducted by ORD and OPP 

scientists since 2007 on these models, 

and will consist of: 

(i) A formal review of SHEDSMultimedia version 4 which now 

includes dietary as well as both 

applicator and post-application 

residential exposures, and allows for 

cumulative as well as aggregate 

assessments; 

(ii) A peer consult on refinements to 

the PBPK models and how SHEDS 

outputs are introduced into and used by 

PBPK models; and 

(iii) Demonstration of the application 

of linked SHEDS-PBPK models with a 

permethrin case study. 

The methods and models reviewed by 

this SAP will provide new science and 

data that will inform the CRA for 

pyrethroids and support future 

cumulative risk assessments. The 

overall goal of this SAP is to review 

these individual and linked state-of-thescience exposure and dose assessment 

tools with a permethrin case study to 

support the Agency’s pyrethroid CRA. 

The purpose of this review is to 

request input from the SAP on this 

updated version of the models and 

related software. Specifically, the FIFRA 

SAP Panel at this meeting will be asked 

to review: 

(i) The dietary module of SHEDSMultimedia version 4, including 

algorithms, inputs, and results 

illustrated with a permethrin case study; 

(ii) The residential module of SHEDSMultimedia version 4, including 

algorithms, inputs, and results 

illustrated with a permethrin case study; 

(iii) The SHEDS-Multimedia version 4 

aggregate (dietary and residential 

modules combined) permethrin case 

study, including algorithms, inputs, and 

results; 

(iv) Update on PBPK modeling since 

the 2007 SAP, and approaches for and 

results of linking SHEDS-Multimedia 

with PBPK models, illustrated with a 

permethrin case study; and 

(v) Plans for a mini-cumulative (2-3 

chemicals) cumulative pyrethroids 

assessment, including proposed 

methodologies using linked SHEDSMultimedia and PBPK models. 

Review of the SHEDS-Multimedia 

model (both dietary and residential 

modules) will include review of: The 

approaches, methodology, and 

algorithms used in SHEDS; annotated 

SHEDS SAS code; the SHEDS Graphical 

User Interface (GUI) and its ease of use; 

and technical and user manuals. The 

Panel will be asked to focus on nonchemical-specific default inputs at this 

SAP meeting. While a permethrin case 

study is being presented for model 

illustration and evaluation purposes, the 

Panel will not be asked to assess 

permethrin outputs. 

Overall, the science and products 

being reviewed in this SAP provide 

exposure and risk assessors within and 

outside the Agency with an externally 

peer-reviewed physically-based, 

probabilistic human exposure model for 

multimedia, multi-route/pathway 

chemicals. In addition, the issues 

associated with refinements to PBPK 

models and how SHEDS outputs are 

linked to and used by PBPK models will 

be discussed both in general and by a 

demonstration of the application of 

linked SHEDS-PBPK models to a 

permethrin case study. It is anticipated 

that the review of this material by the 

SAP will assist ORD and OPP in both 

producing a plan for applying these 

tools to inform any future pyrethroids 

CRA and a generalizable approach that 

can be applied to other chemicals in the 

future. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to FIFRA SAP, FIFRA SAP composition 

(i.e., members and ad hoc members for 

this meeting), and the meeting agenda 

will be available by late June. In 

addition, the Agency may provide 

additional background documents as the 

materials become available. You may 

obtain electronic copies of these 

documents, and certain other related 

documents that might be available 

electronically, at http:// 

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/ 

scipoly/sap. 

FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90–days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP website or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1
Federal Register / Vol. 75, No. 83 / Friday, April 30, 2010 / Notices 22783 

Dated: April 27, 2010. 

Frank Sanders, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. 2010–10231 Filed 4–29–10; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2010–0378; FRL–8823–4] 

FIFRA Scientific Advisory Panel; 

Notice of Public Meeting 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: There will be a 1–day 

meeting of the Federal Insecticide, 

Fungicide, and Rodenticide Act. 

Scientific Advisory Panel (FIFRA SAP) 

to consider and review a set of scientific 

issues related to the Comparative Adult 

and Juvenile Sensitivity Toxicity 

Protocols for Pyrethroids. 

DATES: The meeting will be held on July 

23, 2010, from 8:30 a.m. to 

approximately 5 p.m. 

Comments. The Agency encourages 

that written comments be submitted by 

July 8, 2010 and requests for oral 

comments be submitted by July 15, 

2010. However, written comments and 

requests to make oral comments may be 

submitted until the date of the meeting, 

but anyone submitting written 

comments after July 8, 2010 should 

contact the Designated Federal Official 

(DFO) listed under FOR FURTHER

INFORMATION CONTACT. For additional 

instructions, see Unit I.C. of the 

SUPPLEMENTARY INFORMATION. 

Nominations. Nominations of 

candidates to serve as ad hoc members 

of FIFRA SAP for this meeting should 

be provided on or before May 14, 2010. 

Webcasting. This meeting may be 

webcast. Please refer to the FIFRA SAP’s 

website, http://www.epa.gov/scipoly/ 

SAP/ for information on how to access 

the webcast. Please note that the 

webcast is a supplementary public 

process provided only for convenience. 

If difficulties arise resulting in 

webcasting outages, the meeting will 

continue as planned. 

Special accommodations. For 

information on access or services for 

individuals with disabilities, and to 

request accommodation of a disability, 

please contact the DFO listed under FOR

FURTHER INFORMATION CONTACT at least 

10 days prior to the meeting to give EPA 

as much time as possible to process 

your request. 

ADDRESSES: The meeting will be held at 

the Environmental Protection Agency, 

Conference Center, Lobby Level, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA 22202. 

Comments. Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPP–2010–0378, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001. 

• Delivery: OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S–4400, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket 

Facility’s normal hours of operation 

(8:30 a.m. to 4 p.m., Monday through 

Friday, excluding legal holidays). 

Special arrangements should be made 

for deliveries of boxed information. The 

Docket Facility telephone number is 

(703) 305–5805. 

Instructions. Direct your comments to 

docket ID number EPA–HQ–OPP–2010– 

0378. If your comments contain any 

information that you consider to be CBI 

or otherwise protected, please contact 

the DFO listed under FOR FURTHER

INFORMATION CONTACT to obtain special 

instructions before submitting your 

comments. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov website is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD-ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

is not placed on the Internet and will be 

publicly available only in hard copy 

form. Publicly available docket 

materials are available either in the 

electronic docket at http:// 

www.regulations.gov, or, if only 

available in hard copy, at the OPP 

Regulatory Public Docket in Rm. S– 

4400, One Potomac Yard (South Bldg.), 

2777 S. Crystal Dr., Arlington, VA. The 

hours of operation of this Docket 

Facility are from 8:30 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305–5805. 

Nominations, requests to present oral 

comments, and requests for special 

accommodations. Submit nominations 

to serve as ad hoc members of FIFRA 

SAP, requests for special seating 

accommodations, or requests to present 

oral comments to the DFO listed under 

FOR FURTHER INFORMATION CONTACT. 

FOR FURTHER INFORMATION CONTACT: 

Sharlene R. Matten, DFO, Office of 

Science Coordination and Policy 

(7201M), Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001; telephone 

number: (202) 564–0130; fax number: 

(202) 564–8382; e-mail address: 

matten.sharlene@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this Action Apply to Me? 

This action is directed to the public 

in general. This action may, however, be 

of interest to persons who are or may be 

required to conduct testing of chemical 

substances under the Federal Food, 

Drug, and Cosmetic Act (FFDCA), 

FIFRA, and the Food Quality Protection 

Act of 1996 (FQPA). Since other entities 

may also be interested, the Agency has 

not attempted to describe all the specific 

entities that may be affected by this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the DFO 

listed under FOR FURTHER INFORMATION

CONTACT. 


wwoods2 on DSK1DXX6B1PROD with NOTICES_PART 1