Cy

tokinins 116801, 116802 Product Chemistry

—Registration Review

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

**MEMORANDUM SUBJECT**  : Product Chemistry Scoping Document for the Registration Review o Name . **Registration Review Case #: PC Code:**  **CAS Numbers: Chemical Class:**  **FROM:** Sadaf Shaukat , Biologist

Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P) **TO :**  Cheryl Greene , Regulatory Action Leader Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)
**ACTION REQUESTED** A preliminary

assessment of available information on product chemistry data associated with the biopesticide c ytokinins in support of the development of a Registration Review Work Plan. Case Number: Registration Review

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460
8/15/2012 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION Product Chemistry

Scoping Document for the Registration Review o **Registration Review Case #: 4107**  **116801, 116802 525**  **- 79**  **- 1**  **Biochem ical**  Biologist /s/ 8/15/12 Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)

, Regulatory

Action Leader Biochemical Pesticides Branch

Pollution Prevention Division (7511P)
A preliminary

assessment of available information on product chemistry data associated with in support of the development of a Registration Review Work Plan. Case Number: 4107

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION Product Chemistry

Scoping Document for the Registration Review o f Chemical

A preliminary

assessment of available information on product chemistry data associated with in support of the development of a Registration Review Work Plan.Cy

tokinins Case Number: 4107 116801, 116802 **Introduction** The EPA has made the determination that there is adequate information available on c yt okinins , including c yt okinin, kinetin, and N 6

- b enzyladenine , and does not foresee the need for additional biochemical pesticide product chemistry data for products that currentl y contain c yt okinins as the technical grade active ingredient. The three substances are plant growth regulators, which enhance the growth and development of plants . Cy

tokinin products have been registered with the EPA since 1978. Currentl y there are sixty- eight active registrations of products containing cy tokinins. The Agency exempts cy

tokinins from the requirement of a tolerance when used as a plant regulator on plants, seeds, or cuttings and on all food commodities after harvest (see 40 CFR 180.1157). In addition, the Agency exempts N 6

- benzyladenine from the requirement of a tolerance when used in or on apple and pear at a rate of ≤182 grams of active ingredient per acre per season, and in or on pistachio when applied at a rate of ≤60 grams of active ingredient per acre per season (see 40 CFR 180.1150). Concerning the product chemistry of cy tokinins , all biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 2. While no further product chemistry data are necessary

for the products currently

registered, future registrations must adequatel y address all of the b iochemical pesticides product chemistry data requirements.Cy

tokinins Case Number: 4107 116801, 116802

3 **Table 1. Product Identity and Composition for Cytokinin/Kinetin**  **Common Name** Cy tokinin/Kinetin **Chemical Name, IUPAC** N - (2 - Furanylmethyl) - 9H - purin - 6 - amine **Molecular Weight** 215.21 g/mol **PC Code** 116801/116802 **CAS Registry Number** 525 - 79 - 1 **Empirical Formula** 

### C 10 

### H 9

### N 5 

### O **Registration Review Case Number** 4107 **Chemical Structure**Cy

tokinins Case Number: 4107 116801, 116802

4 **Product Chemistry Summary** The Agency

has conducted a review of the available product chemistry data and information. These data are summarized below. **Table 2. Biochemical Pesticides Product Chemistry Data Requirements for Chemical Name**  **Guideline No. Physical and Chemical**  **Properties Status**  **1 Value**  **MRID /**  **Source 830.1100**  Product Identity and

Com position A Refer to Table 1. N/A **830.1200** Description of starting

materials, production and formulation process A CBI 48541201 **830.1400** Discussion of formation of

im purities A CBI 48541201 **830.1700** Preliminary analysis A CBI 48541202 **830.6302** Color A White 44911003 **830.6303** Phy sical state A Crystals 44911003 **830.6304** Odor A Odorless 44911003 **830.6313** Stability to normal and

elevated temperatures, metals and metal ions N/A **830.7000** pH A 7.4 (25 o C) 44911003 **830.7050** UV/Visible light absorption N/A **830.7200** Melting point/melting range A 265 - 266 o C 44911003 **830.7220** Boiling point/boiling range A 524.4 0 C (at 760 mmHg) LookChem **830.7300** Density A 1.4374 g/cm3 44911003 **830.7520** Particle size, fiber length,

and diameter distribution N/A **830.7550 830.7560**  **830.7570** Partition coefficient (n Octanol/Water) N/A **830.7840** Water solubility A 51.0 mg/L (25 o C) 44911003 **830.7950** Vapor pressure A Negligible FisherScien

- tific 1. A=Acceptable. N/A=Not Applicable. N/D=Not DeterminedCy

tokinins Case Number: 4107 116801, 116802

5 **References** Fisher Scientific, Online. 8/15/2012. http://www.fishersci.com/ecomm/servlet/msdsproxy?productName=BP9421&productDescriptio n=KINET IN+1GM&catNo=BP942 - 1&vendorId=VN00033897&storeId=10652 LookChem , Online. 08/15/2012. http://www.lookchem.com/cas - 525/525 - 79 - 1.html Merck Index , Online. 0 8/14/2012 . Shi, Xiaoluo and Qin, Guohong. Color, Phy sical State, Odor, Melting Point, Density , Solubility and pH of Kinetin Technical . Private Study by LT BioSy

n, Inc. Submitted to EPA. MRID 44911003 .