Exhibit
31.1

CERTIFICATION
OF THE

PRINCIPAL
EXECUTIVE OFFICER

PURSUANT
TO

RULE
13a-14(a) AND RULE 15d-14(a)

UNDER
THE

SECURITIES
EXCHANGE ACT OF 1934,

AS
ADOPTED PURSUANT TO

SECTION
302 OF THE SARBANES-OXLEY ACT OF 2002



I,
Joseph Hernandez, hereby certify that:



| | 1. | I
                                            have reviewed this Annual Report on Form 10-K of Blue Water Vaccines Inc.
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| | 2. | Based
                                            on my knowledge, this report does not contain any untrue statement of a material fact or
                                            omit to state a material fact necessary to make the statements made, in light of the circumstances
                                            under which such statements were made, not misleading with respect to the period covered
                                            by this report;
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| | 3. | Based
                                            on my knowledge, the financial statements, and other financial information included in this
                                            report, fairly present in all material respects the financial condition, results of operations
                                            and cash flows of the registrant as of, and for, the periods presented in this report;
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| | 4. | The
                                            registrant’s other certifying officer and I are responsible for establishing and maintaining
                                            disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the registrant and have:
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| | a. | Designed
                                            such disclosure controls and procedures, or caused such disclosure controls and procedures
                                            to be designed under our supervision, to ensure that material information relating to the
                                            registrant, including its consolidated subsidiaries, is made known to us by others within
                                            those entities, particularly during the period in which this report is being prepared;
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| | b. | (Paragraph
                                            omitted pursuant to SEC Release Nos. 33-8238/34-47986 and 33-8392/34-49313);
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| | c. | Evaluated
                                            the effectiveness of the registrant’s disclosure controls and procedures and presented in this
                                            report our conclusions about the effectiveness of the disclosure controls and procedures,
                                            as of the end of the period covered by this report based on such evaluation; and
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| | d. | Disclosed
                                            in this report any change in the registrant’s internal control over financial reporting
                                            that occurred during the registrant’s most recent fiscal quarter (the registrant’s
                                            fourth fiscal quarter in the case of an annual report) that has materially affected, or is
                                            reasonably likely to materially affect, the registrant’s internal control over financial
                                            reporting; and
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| | 5. | The
                                            registrant’s other certifying officer and I have disclosed, based on our most recent
                                            evaluation of internal control over financial reporting, to the registrant’s auditors
                                            and the audit committee of the registrant’s board of directors:
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| | a. | All
                                            significant deficiencies and material weaknesses in the design or operation of internal control
                                            over financial reporting which are reasonably likely to adversely affect the registrant’s
                                            ability to record, process, summarize and report financial information; and
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| | b. | Any
                                            fraud, whether or not material, that involves management or other employees who have a significant
                                            role in the registrant’s internal control over financial reporting.
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|Date: March 31,
    2022 | /s/Joseph Hernandez        
|------------------------ | ---------------------------
|                         | Joseph Hernandez           
|                         | Chief Executive
    Officer