### Cover Letter

Supplemental Cover Letter for 1,5-Pentanediamine Pre-Manufacturing Notice Cathay Industrial Biotech, Ltd Cathay Industrial Biotech, Ltd (Cathay) is providing this Pre-Manufacturing Notice (PMN) for the importation of 1,5- pentanediamine (CAS 462-94-2,) into the United States. It is Cathay’s intention to produce this product at our manufacturing facility in Shandong Province, Peoples Republic of China and distribute for consumption in China, the EU and North America. It is possible that should demand warrant, Cathay will consider placing a manufacturing facility in the United States using the same process identified within this submission. Cathay has an impressive history since 2003 of producing monomers by non-chemical techniques, such as fermentation, and providing renewable options to the polymer industry. Cathay’s 1,5-pentanediamine is such a monomer, made entirely of renewable carbons and using sugar as a starting material. Ultimately, it is Cathay’s intention and goal to produce this produce 1,5-pentanediamine from biomass. It is anticipated that 1,5-pentanediamine's dominant market and use will be as a monomer for polyamides (Nylon). 1,5-pentanediamine provides a renewable and performance-added option to hexamethylene diamine, the most common monomer used in polyamides 1,5-pentanediamine is commonly known as cadaverine, a liquid commonly created naturally by the decomposition of deceased tissue. Specifically, 1,5-pentanediamine is produced in the environment by the decarboxylation of the amino acid lysine. 1,5-pentanediamine is also found in living beings. Cathay has provided toxicity information from the Hazardous Substances Data Bank (HSDB), which is a database of the National Library of Medicine’s TOXNET system and EPA’s Toxicity Estimation Software Tool (TEST). The former provides peer reviewed information which Cathay believes is reliable, whereas results from TEST are considered predictive since findings are based upon a variety of assumptive models.

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Page 3 SANITIZED SUBMISSIONAlexander Kedo Business Director, Americas Cathay Industrial Biotech, Ltd 730 Eric Court Mt. Zion IL 62549 kedo@cathaybiotech.com Alexander Kedo Business Director, Americas Cathay Industrial Biotech, Ltd 367 Bethany Avenue Powell OH 43065 kedo@cathaybiotech.com 614-761-1970

Alex Kedo Business Director, Americas Cathay Industrial Biotech, Ltd. 367 Bethany Avenue Powell OH 43065 kedo@cathaybiotech.com 614-761-1970



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1,5-Pentanediamine

462-94-2 

### X NH2(CH2)5NH2 See Attachment 002 (5DA Structure.pdf)

5DA Structure.pdf Page 5 SANITIZED SUBMISSIONPage 6 SANITIZED SUBMISSIONPage 7 SANITIZED SUBMISSIONPage 8 SANITIZED SUBMISSION1,5-pentanediamine, cadaverine, pentamethylene diamine

CBIO N5 Diamine

Cadaverine, 1,5-pentanediamine 1,5-Pentanediamine Chromatogram Sanitized.JPG XXX XXX XXX X XXX XXX XXX X

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1,5-pentanediamine can be used as a monomer to make polyamides. Typically polyamides are produced by reacting a diacid with a diamine. The most common diamine currently used to make polyamides is hexamethylenediamine (HMDA), the six carbon variant to the subject of this PMN. HMDA is also used to make diisocyanates. Producers of these diisocyanates have expressed interest in 1,5-pentanediamine as a substitute for HMDA. As a monomer for polyamides XXX X XXX X XXX XXX XXX XXX X
As an ingredient to produce metamethylene 1,5 diisocyante XXX X XXX X XXX XXX XXX XXX X

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See Attachment 001 (1,5-Pentanediamine Process Non-confidential.pdf)

1,5-Pentanediamine Process Non-confidential.pdf XXX 

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Page 15 SANITIZED SUBMISSIONP10SB1(a)(4)1 Part II, Section B, 1(a)(4). Operation Site Locations

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Page 17 SANITIZED SUBMISSIONPage 18 SANITIZED SUBMISSION001 1,5-Pentanediamine Process Non-confidential 1,5-Pentanediamine Process Non-confidential.pdf Pt.2, Sec.B, 1a. 1 002 1,5-Pentanediamine 5DA Structure.pdf Pt.I, Sec.B, 1e. 1 003 1,5-Pentanediamine MSDS DN5 MSDS 20130916 V4.pdf 7 004 Technical Data Sheet - 1,5-Pentanediamine TDS DN5 20120416.pdf 1 005 1,5-Pentanediamine Chromatogram Sanitized 1,5-Pentanediamine Chromatogram Sanitized.JPG Pt.I, Sec.B, 3. 1 006 Predicted Mutagenicity for 1, 5,-Pentanediamine from Consensus method Predicted Mutagenicity for 1, 5,- Pentanediamine from Consensus 5 007 Predicted Mutagenicity for 1, 5,-Pentanediamine from FDA method Predicted Mutagenicity for 1, 5,- Pentanediamine from FDA 5 008 Predicted Mutagenicity for 1, 5,-Pentanediamine from Hierarchical clustering method Predicted Mutagenicity for 1, 5,- Pentanediamine from 5 009 Predicted Mutagenicity for 1, 5,-Pentanediamine from Nearest neighbor method Predicted Mutagenicity for 1, 5,- Pentanediamine from Nearest 5 010 !,5 Pentanediamine Toxicity Info from Hazardous Substances Data Bank !,5 Pentanediamine Toxicity Info from HSDB.pdf 9

Page 19 SANITIZED SUBMISSION0.87 Measured

mutual sol. Measured 25 9 Measured 178 Measured 760

12.6 Measured 5% in water

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### ATTACHMENT HEADER SHEET Attachment Number 001 Attachment Name 1,5-Pentanediamine Process Non-confidential 

### Associated PMN Section Number

Pt.2, Sec.B, 1a. Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 002 Attachment Name 1,5-Pentanediamine 

### Associated PMN Section Number

Pt.I, Sec.B, 1e. Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 003 Attachment Name 1,5-Pentanediamine MSDS 

### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 004 Attachment Name Technical Data Sheet - 1,5-Pentanediamine 

### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 005 Attachment Name 1,5-Pentanediamine Chromatogram Sanitized 

### Associated PMN Section Number

Pt.I, Sec.B, 3. Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 006 Attachment Name Predicted Mutagenicity for 1, 5,-Pentanediamine from Consensus method



### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 007 Attachment Name Predicted Mutagenicity for 1, 5,-Pentanediamine from FDA method



### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 008 Attachment Name Predicted Mutagenicity for 1, 5,-Pentanediamine from Hierarchical clustering method



### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 009 Attachment Name Predicted Mutagenicity for 1, 5,-Pentanediamine from Nearest neighbor method



### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156

### ATTACHMENT HEADER SHEET Attachment Number 010 Attachment Name !,5 Pentanediamine Toxicity Info from Hazardous Substances Data Bank



### Associated PMN Section Number

N/A Does not contain CBI 

### Report Number CATH131107270091156