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                                                                   EXHIBIT 10.10

                                    ADDENDUM
                   TO SUPPLY AGREEMENT DATED MARCH 25TH, 2004

             ENTERED INTO AND SIGNED ON THIS 30TH DAY OF JUNE, 2004

BY AND BETWEEN:        OMRIX BIOPHARMACEUTICALS LTD.
                       whose address for the purposes hereof is:
                       MDA Blood center
                       Tel Hasbomer Hospital
                       Kiryat Ono Israel
                       (Hereinafter referred to as: "OMRIX")

                                                              OF THE FIRST PART;

                                       AND

                       PLASTMED LTD. REG. NO. 51-352193-7
                       a company registered in Israel,
                       whose address for the purposes hereof is
                       at 5 Beit Harishomm St.
                       Emek Hefer Industrial Zone 388 00
                       (Hereinafter referred to as: "PLASTMED")

                                                             OF THE SECOND PART:

WHEREAS:    The Parties have entered on March 25th, 2004
            into a manufacture and supply AGREEMENT (hereinafter the
            "AGREEMENT") of Quixil application Devices (as defined in the
            Agreement); and

WHEREAS:    The parties wish to amend certain provisions of the
            Agreement relating to the molds required for the manufacture
            of the Devices and terms of payment relating thereto, as more fully
            set forth in this Addendum to the Agreement (the "ADDENDUM").

NOW THEREFORE IT IS AGREED, DECLARED AND STIPULATED BETWEEN THE PARTIES AS
FOLLOWS:

1.    The Preamble to this Addendum forms an integral part hereof and shall be
      binding upon the parties as the Addendum itself.

2.    This Addendum forms an integral part of the Agreement, and unless
      specifically amended herewith, the provisions of the Agreement shall be
      binding upon the parties hereto and shall remain in full force and effect.

3.    Without prejudice to the provisions of Section 5.2 of the
      Agreement and notwithstanding any other provision or the Agreement or the
      contrary, it is agreed that PlastMed is solely and fully responsible for
      the design and planning of the mold, and that the molds will be ready for
      manufacture of the Devices in not later than 7 (seven) months as of the
      signing date of the Agreement.


      PORTIONS OF THIS EXHIBIT MARKED BY AN *** HAVE BEEN OMITTED PURSUANT
       TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE
                      SECURITIES AND EXCHANGE COMMISSION.

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                                       2

      In view of the passage of time since the date the Agreement was executed
      by the Parties, the Parties hereby agree that all dates and periods
      mentioned therein shall be deemed as postponed and delayed by six weeks.

4.    Payment terms of the amount of (euro) *** (*** Euro) described in
      Section 5.2 of the Agreement are hereby replaced with the following terms:

      4.1.  (euro) *** (*** Euro) designated to cover setup and local expenses,
            shall be paid in advance upon the signing of this Addendum.

      4.2.  The balance in the amount of (euro) *** (*** Euro) shall be paid
            within 30 days of signature hereof (the "BALANCE PAYMENT DATE"),
            against the receipt of" autonomous bank guaranties, as
            stipulated below, issued by one of the leading bank in Israel, in
            the form attached as ANNEX A hereto:

            4.2.1.A Bank Guarantee, in the form attached as ANNEX A hereto
                  (hereinafter: a "BANK GUARANTY"), in the amount of (euro)
                  *** (*** Euro), valid for a period of 20 (TWENTY) WEEKS
                  commencing upon the Balance Payment Date.

                  Without prejudice to the autonomous nature of this Bank
                  Guaranty, Omrix may exercise this Bank Guaranty in the event
                  of failure by PlastMed to supply Omrix detailed design
                  drawings for the following molds Vial Cup 2.5 ml, Vial holder,
                  syringe body and valve care within 14 (fourteen) weeks of the
                  date hereof all in accordance with the amended provisions of
                  the Agreement and the Technical Specifications, attached as
                  Annex A thereto.

                  In the event the above design drawings were delivered on time,
                  Omrix shall have a period of 2 (two) weeks from receipt of
                  such detailed design drawings, to approve or disapprove
                  whether they comply with the Technical Specifications
                  attached as Annex A to the Agreement.

                  In the event of an approval notice, Omrix shall return
                  immediately the Guaranty to PlastMed. In the event of a
                  disapproval notice Omrix shall give written details as to the
                  nature of the disapproval including any and all defect
                  and / or flaws ("DETAILS OF DISAPPROVAL) and PlastMed shall
                  take all actions required in order to correct and amend same
                  within a period of 4 (four) weeks commencing upon the receipt
                  of the Details of Disapproval. Upon the end of such 4 (four)
                  weeks period Omrix shall be entitled to exercise this Bank
                  Guaranty only if PlastMed failed to amend the defects and / or
                  flaws. In any other event, Omrix shall return the Bank
                  Guaranty immediately to PlastMed.
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                                       3

            4.2.2.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 20 (TWENTY) WEEKS commencing upon
                        the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to supply detailed design
                        drawings for the syringe holder molds within 14
                        (fourteen) weeks of the date hereof all in accordance
                        with the amended provisions of the Agreement and the
                        Technical Specifications attached as Annex A thereto.

                        In the event the above design drawings were delivered on
                        time, Omrix shall have a period of 2 (two) weeks of
                        receipt of such detailed design drawings, to approve or
                        disapprove whether they comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed. In the event of a
                        disapproval notice Omrix shall give written details as
                        to the nature of the disapproval including any and all
                        defect and or flaws ("DETAILS OF DISAPPROVAL") and
                        PlastMed shall take all actions required in order to
                        correct and amend same within a period of 4 (four) weeks
                        commencing upon the receipt of the Details of
                        Disapproval. Upon the end of such 4 (four) weeks period
                        Omrix shall be entitled to exercise this Bank Guaranty
                        only if PlastMed failed to amend the defects and / or
                        flaws. In any other event, Omrix shall return the Bank
                        Guaranty immediately to PlastMed.

            4.2.3.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 35 (THIRTY FIVE) WEEKS commencing
                        upon the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to have the following molds
                        supplied: Vial Cup 2.5ml, Vial holder, syringes body and
                        valve core within 30 (thirty) weeks of the date hereof
                        all in accordance with the amended provisions of the
                        Agreement and the Technical Specifications attached as
                        Annex A thereto.

                        In the event the above molds were delivered on time,
                        Omrix shall have a period of 2 (two) weeks of receipt of
                        notice of such delivery, to approve or disapprove
                        whether the molds comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed. In the event of a
                        disapproval notice Omrix shall give written details as
                        to the

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                                       4

                        nature of the disapproval including my and all defect
                        and or flaws ("DETAILS OF DISAPPROVAL") and PlastMed
                        shall take all actions required in order to correct and
                        amend same within a period of 4 (four) weeks commencing
                        upon the receipt of the Details of Disapproval. Upon the
                        end of such 4 (four) weeks period Omrix shall be
                        entitled to exercise this Bank Guaranty only if PlastMed
                        failed to amend the defects and / or flaws. In any other
                        event, Omrix shall return the Bank Guaranty immediately
                        to PlastMed.

            4.2.4.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 37 (THIRTY SEVEN) WEEKS commencing
                        upon the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to have the molds for the
                        syringes holder set supplied within 30 (thirty) weeks of
                        the date hereof all in accordance with the amended
                        provisions of the Agreement and the Technical
                        Specifications attached as Annex A thereto.

                        In the event the above molds were delivered on time,
                        Omrix shall have a period of 2 (two) weeks of receipt of
                        notice of such delivery, to approve or disapprove
                        whether the molds comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed.

                        In the event of a disapproval notice Omrix shall give
                        written details as to the nature of the disapproval
                        including any and all defect and / or flaws ("DETAILS OF
                        DISAPPROVAL") and PlastMed shall take all actions
                        required in order to correct and amend same within a
                        period of four (four) weeks commencing upon the receipt
                        of the Details of Disapproval Upon the end of such 4
                        (four) weeks period Omrix shall of entitled to exercise
                        this Bank Guaranty only if PlastMed failed to amend the
                        defects and / or flaws. In any other event Omrix shall
                        return the Bank Guaranty immediately to PlastMed.

            4.2.5.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 44 (forty four) WEEKS commencing
                        upon the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to timely supply the first
                        Purchase Order of Devices, all in accordance with the
                        amended provisions of the Agreement and the Technical
                        Specifications attached as Annex A thereto.

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                                       5

                        In the event of timely delivery, Omrix shall have a
                        period of 4 (four) weeks to approve or disapprove
                        whether the Devices comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed.

                        In the event of a disapproval notice, Omrix shall give
                        written details as to the nature of the disapproval
                        including any and all defect and / or flaws ("DETAILS OF
                        DISAPPROVAL") and PlastMed shall take all actions
                        required in order to correct and amend same within a
                        period of 4 (four) weeks commencing upon the receipt of
                        the Details of Disapproval Upon the end of such 4 (four)
                        weeks period Omrix shall be entitled to exercise this
                        Bank Guaranty only if PlastMed failed to amend the
                        defects and / or flaws. In any other event Omrix shall
                        return the Bank Guaranty immediately to PlastMed.

            For the avoidance of doubt, in the event that Omrix has not
            delivered PlastMed with a written notice of approval or disapproval
            (as the case may be) within the periods prescribed above ("DELAY"),
            all periods and corresponding time bars in the Agreement shall be
            postponed and extended respectively, to reflect any such Delay.

      4.3.  Omrix shall reimburse PlastMed for half of the Bank Guaranty
            expenses

      4.4.  For avoidance of doubt exercise by Omrix of any or all of the Bank
            Guaranties shall not derogate from any right and/or remedy it may
            have under the Agreement and/or the Law, provided that, in any
            event, Omrix shall not be entitled to receive or demand the molds,
            as prescribed in section 5.6 of the Agreement, until after due
            payment of the entire sum in section 4 above and after it has
            returned all the un-exercised Bank Guarantees detailed in
            sub-sections 4.2.1-4.2.5

IN WITNESS WHEREOF THE PARTIES HERETO HAVE SIGNED THIS ADDENDUM:

 /s/ Authorized Officer              /s/ Nissim Mashiach  /s/ Michael Burshtine
-----------------------              ------------------------------------------
       PLASTMED                                       OMRIX
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                                       6

                                    ANNEX A
                                 BANK GUARANTEE

Issuing Bank:

________________
__________ branch,
Tel Aviv, ISRAEL
(the "BANK")

To:
Omrix Biopharmaceuticals Ltd.
MDA Blood center
Tel Hashomer Hospital
Kiryat Ono, Israel
(the "BENEFICIARY")

We hereby establish our irrevocable autonomous Bank Guarantee No.________ (the
"GUARANTEE") in favor of OMRIX BIOPHARMACEUTICALS LTD. (hereinafter the
"BENEFICIARY"), at the request and for the account of PlastMed Ltd. (hereinafter
"PLASTMED") with regard to the Agreement between the Beneficiary and PlastMed
dated March 25th, 2004 and amended on June ____, 2004.

Accordingly, we hereby guarantee and undertake to pay the Beneficiary in
accordance with the terms hereof, a sum which shall not exceed the amount of
____________________________Euro ((euro)_______), within 7 (seven) working days
from receipt of a written original demand duly signed by the Beneficiary.

This Guarantee shall come into force upon remittance by the Beneficiary to
PlastMed's designated account of (euro) *** (*** Euro) and will expire
by_______, and will be considered null and void whether or not it is returned
to us.

This Guarantee is neither transferable nor assignable in any way whatsoever.

This Guarantee shall be governed by and construed according to the laws of the
State of Israel. Any dispute arising under or in relation to this Guarantee
shall be resolved solely and exclusively in the Tel-Aviv-Jaffa competent
courts, and each of the parties hereby submits irrevocably to the jurisdiction
of such courts.

All notices and other communications required or permitted hereunder to be given
to the Bank shall be in writing in the Hebrew or in the English language and
shall be mailed by registered mail, or otherwise delivered by courier, by hand
or by messenger addressed to Bank's address at_____________________________ ,
Tel-Aviv or at such Other address as the Bank shall notify each other party in
writing as above provided.

Yours faithfully,

________________