1.
    
    DESCRIPTION OF THE LEASED PREMISES. Subject to the terms and
conditions of this Lease, Landlord does hereby demise and lease to Tenant, and Tenant
hire from Landlord certain premises being described as follows:14,344 square feet in Units A1-100, A1-200, B1-201, B1-202, B1-400 and B1-500(the
Leased Property) located in the PURDUE TECHNOLOGY CENTER at 3000 Kent Avenue, West
Lafayette, Indiana (the Building). The Leased Property is more particularly shown on
EXHIBIT A, attached to this Lease and made a part of this Lease by this
reference.2.
    
    RENT Section 4ai
 i.
    
    Initial Term. For the Initial Term, Tenant agrees to pay to
Landlord rent in the minimum aggregate amount of Three Hundred Twenty-Two
Thousand Sixty and 68/100 Dollars ($322,060.68) (the Rent). Tenant agrees
to pay the Rent in consecutive monthly installments (Monthly Rent
Installment) of Twenty-Seven Thousand Eight Hundred Thirty-Two and 43/100
Dollars ($27,832.43) per month, in advance of the first day of each month,
commencing at the Commencement Date, as defined herein, but not later than the
date Tenant opens for business. The Rent is equal to $17.45 per square foot
for the portion of the Leased Property devoted to office uses; $32.800 per
square foot for the portion of the Leased Property used as a laboratory, per
year during the Initial Term; and $886.31 per month for workstations (until
2015).During the Initial Term and any subsequent Extension Periods, the Rent
shall be adjusted annually and effective January 1st. Each
year during the Lease Term, the Rent shall be equal to the rental rate
established for the Building (Building Rate) for the subsequent calendar
year multiplied by the square feet occupied by Tenant and shall remain in
effect until the Building Rate changes. The Building Rate shall be
determined by Landlord and provided, by written notice, to Tenant not
later than November 1st of each calendar year. The Building
Rate increase shall not exceed five percent (5%) during any given year.
In no event shall the Rent be adjusted more frequently than annually. The
new Rent as so
adjusted shall begin each calendar year on January 1st and
continue at the adjusted rate until the next annual adjustment of the
Building Rate. The




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corresponding Monthly Rent Installment shall also be
adjusted to be consistent with the change in the Rent.
 3.
    
    It is further agreed that all of the terms and conditions of said
aforementioned Lease Agreement dated March 1, 2010, except as hereby amended, are
hereby affirmed and shall remain in full force and effect during the remainder of the
term thereof.
  PURDUE RESEARCH FOUNDATION
    
    ENDOCYTEBy:
    
    /s/ Gregory W. Deason
    
    By:
    
    /s/ Ron EllisGregory W. Deason
    
        
    Ron EllisVice President  Real Estate and
    
    
    
    President and CEOResearch Park DevelopmentATTEST:By:
    
    /s/ David L. Hodde
    
    By:David L. HoddeAssistant Vice President andDirector  Real Estate/Physical Facilities




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EXHIBIT A
 Unit A1-100 Lab Space Unit B1-500 Lab Space
    
    4,069 square feet
690 square feetTotal Lab Space
    
    4,759 square feetUnit A1-200 Office Space 
Unit B1-400 Office Space 
Unit B1-201 Office Space 
Unit B1-202 Office Space
    
    9,131 square feet
(included in A1-200)
230 square feet
224 square fettTotal Office Space
    
    9,585 square feet




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