Appendix B. Table of Generic Data Requirements and Studies Used to Make the 

Reregistration Decision for Metam-sodium, Metam-potassium, and MITC (PC 

039003, 039002, 068103)

GUIDE TO APPENDIX B

Appendix B contains a listing of data requirements which support the 

reregistration for active ingredients within the case covered by this RED. It contains 

generic data requirements that apply to metam-sodium, metam-potassium, and MITC in 

all products, including data requirements for which a “typical formulation” is the test 

substance.

The data table is organized in the following formats:

1. Data requirement (Column 1). The data requirements are listed in the order in 

which they appear in 40 CFR 158. The reference numbers accompanying each 

test refer to the test protocols set in the Pesticide Assessment Guidance, which is 

available from the National Technical Information Service, 5285 Port Royal 

Road, Springfield, VA 22161. (703) 487-4650.

2. Use Pattern (Column 2). This column indicates the use patterns for which the 

data requirements apply. The following letter designations are used for the given 

use patterns.

A. Terrestrial food

B. Terrestrial feed

C. Terrestrial non-food

D. Aquatic food

E. Aquatic non-food outdoor

F. Aquatic non-food industrial

G. Aquatic non-food residential

H. Greenhouse food

I. Greenhouse non-food

J. Forestry

K. Residential

L. Indoor food

M. Indoor non-food

N. Indoor medical

O. Indoor residential

X . Materials preservatives

Y. Industrial processes and 

water systems-once through

Z. Industrial processes and 

water systems-not once 

through

BB. Wood preservatives

FF. High Exposure 

Antimicrobial

GG. Low Exposure 

Antimicrobial

3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this 

column lists the identifying number of each study. This normally is the Master Record 

Identification (MRID) number, but may be a “GS” number is no MRID number has been 

assigned. Refer to the Bibliography appendix for a complete citation of the study.
Data Requirement

Use Patterns Citations New Guideline Number

Old 

Guideline 

Number

Description

PRODUCT CHEMISTRY

830.1600 61-2A Description of materials used to 

produce the product ALL

41241601, 44453602, 

00162081, 44459101, 

43953901

830.1620 61-2B Description of production process

ALL 41241601, 44453602, 

00162081, 44459101, 

43953901

830.1670 61-2B Formation of Impurities ALL 41241601, 44453602, 

00162081, 43953901

830.1700 62-1 Preliminary Analysis ALL 41241602, 44453603, 

00162080

830.6302 63-2 Color ALL 41241603, 41286003, 

00162079, 45919401

830.6303 63-3 Physical State

ALL 41241603, 41286003, 

43457708, 00162079, 

45919401

830.6304 63-4 Odor1

ALL 41241603, 41286003, 

43457708, 00162079, 

45919401

830.6313 63-13

Stability to normal and elevated 

temperatures, metals, and metal 

ions

ALL 41241603, 41286003,

00162079

830.7000 63-12 pH ALL 41241603, 41286003, 

43457708, 00162079

830.7050 None UV/Visible Absorption ALL 45919401, 45919401,

DATA GAP

830.7200 Melting Point/melting range ALL 45919401

830.7220 63-6 Boiling Point/boiling range

ALL 41241603, 41286003, 

45919401 

830.7300 63-7 Density

ALL 41241603, 41286003, 

43457708, 00162079, 

45919401

830.7370 63-10 Dissociation Constants in Water ALL 41241603, 41286003, 

45919404, 

830.7550 63-11 Partition coefficient, shake flask 

method

ALL 41241603, 41286003, 

45919401

830.7840 63-8

Water solubility: column elution 

method; shake flask method

ALL 41241603, 41286003, 

45919401, 45919403

830.7950 63-9 Vapor Pressure

ALL 41241603, 41286003, 

45919401

ECOLOGICAL EFFECTS

850.1010 72-2 

Acute Toxicity to Freshwater 

Invertebrates ALL

41106203, 40098001, 

42680601, 41819302, 

45919419

850.1025 72-3B Estuarine/Marine Toxicity –

Mollusk

ALL 42632201, DATA GAP

850.1035 72-3C Estuarine/Marine Toxicity – ALL 42476301, 43457708, 

 
Data Requirement

Use Patterns Citations New Guideline Number

Old 

Guideline 

Number

Description

Shrimp DATA GAP

850.1075 72-1A Fish Acute Toxicity Bluegill ALL 42363201, 44523412 , 

DATA GAP

850.1075 72-1B Fish Acute Toxicity – Rainbow 

Trout

ALL 42363202, 44523413, 

45919420

850.1075 72-3A Estuarine/Marine Toxicity – Fish ALL 42436301, DATA GAP

850.1300 Aquatic Invertebrate Lifecycle 

(Freshwater)

ALL 45634001

850.2100 71-1A Avian Acute Oral Toxicity –

Mallard 

ALL 41476402

850.2200 71-2a,b Avian Dietary

ALL 41476403, 42914001, 

00022923, 

42914002, 41476401, 

00022923

850.2300 Avian Reproduction ALL DATA GAP

850.3020 141-1Honey bee acute contact LD50 ALL 00018842, DATA GAP

850.4225 122-1(a) Seedling Emergence, Tier II ALL DATA GAP

850.4250 122-1(b) Vegetative Vigor, Tier II

ALL 45919421, 45919422, 

45919416, 44588903, 

DATA GAP

850.5400 122-2B Aquatic Plant Growth, Tier II ALL DATA GAP

RESIDUE CHEMISTRY

860.1300 Nature of the Residue - Plants C, I

41137101 41137102

41137103 436326024

92097021

860.1340 Residue Analytical Method - Plants C, I

41142502 41631102

41631104 436326014

92098034

860.1360 Multiresidue Method C, I 41631103

860.1500 Crop Field Trials C, I

40951601 40951602

40951603 40951606

40951607 40951608

40951609 41097001 

41097002 41097003

41142501 41142502

41142503 41218101

41218102 41218103

41218104 92098035

92098036 92098037

92098038 92098039

92098040 92098041

92098042 92098043

92098044 92098045

92098046 92098047

92098048 92098049

92098050 92098051

92098052 92098053

92098054 92098055, 

45703705 43703706 
Data Requirement

Use Patterns Citations New Guideline Number

Old 

Guideline 

Number

Description

43703707 45123901

TOXICOLOGY

870.1100 81-1 Acute Oral Toxicity - Rat ALL 41277002, 00162331

870.1200 81-2 Acute Dermal Toxicity – Rat ALL 41277003, 00162330, 

42442501

870.1300 81-3 Acute Inhalation Toxicity – Rat ALL 41277004, 00162327, 

42365605

870.2400 81-4 Primary Eye Irritation - Rabbit ALL 44400401, 41277005, 

00162328

870.2500 81-5 Primary Skin Irritation – Rabbit ALL 41277006, 00162329

870.2600 81-6 Dermal Sensitization ALL 41277007

870.3200 82-2 21-Day Dermal – Rabbit/Rat ALL

870.3100 Subchronic Feeding – Rat/Mouse ALL 41865502, 42117302, 

42117301

870.3150 Subchronic Feeding – Dog ALL

870.3465 82-5

90- Day Inhalation Toxicity –

Rat/Mouse

ALL 00162041, 43514802, 

00162041

870.3700 83-3A Developmental Toxicity – Rat ALL 41577101, DATA GAP

870.3800 83-4

Reproduction and Developmental 

Effects

ALL DATA GAP

870.4100 83-1B Chronic Feeding Toxicity Study -

Dog

ALL 43275801

870.4200 83-2 Carcinogenicity – Mouse/Rat ALL 47067501, 43275802, 

DATA GAP

870.5100 84-2

Bacterial Reverse Mutation Test 

(Ames Assay)

ALL 40305602, 305603

870.5375 84-2

Chromosomal Aberration in 

Chinese Hamster Ovary

ALL 40305605

870.5395 84-2 Unscheduled DNA Synthesis – Rat ALL 40305601, DATA GAP

870.5700 84-2

In vitro mammalian gene mutation 

test

ALL 40305604

870.6200a 81-8 

Acute neurotoxicity screen study in 

rats, Inhalation Acute 

Neurotoxicity

ALL 43465302, 42977801,

42977802, DATA GAP

870.7800 85-7 Immunotoxicity ALL DATA GAP

ENVIRONMENTAL FATE

835.1230 163-1 Soil Adsorption ALL 00152844

835.1240 163-1 Leaching/Adsorption/Desorption ALL 47010302

835.8100 163-3 Field Volatility

ALL 47066501, 45703701, 

45703702, 46969601, 

47572201, 47131601, 

47314301, 45703708, 

45703704, 42659901, 

46379201, 47770001, 

48011601, 48005901, 

47956901, 48115101, 

47813901, 47956701, 

DATA GAP

835.2120 161-1 Hydrolysis ALL 41631101, 00158162

835.2240 161-2 Photodegradation - Water ALL 41517701
Data Requirement

Use Patterns Citations New Guideline Number

Old 

Guideline 

Number

Description

835.2410 161-3 Photodegradation - Soil ALL 42978701

835.4100 162-1 Aerobic Soil Metabolism ALL 40198502

835.4400 162-3 Anaerobic Aquatic Metabolism ALL 43596501

835.6100 164-1 Terrestrial Field Dissipation ALL 41514402, 41798601

OCCUPATIONAL AND RESIDENTIAL EXPOSURE

875.1100 Dermal Exposure – Outdoor F DATA GAP

875.1200 233 Dermal Exposure – Indoor X, Y, Z, BB, 

FF, GG DATA GAP

875.1300 232 Inhalation Exposure – Outdoor 

(Applicator)

X, Y, Z, BB, 

FF, GG

42968401, 45123902, 

45703703, 

875.1400 234 Inhalation Exposure – Indoor X, Y, Z, BB, 

FF, GG DATA GAP

875.1600 235 Application exposure monitoring 

data reporting

X, Y, Z, BB, 

FF, GG DATA GAP

875.1700 236 Product Use Information X, Y, Z, BB, 

FF, GG DATA GAP

875.2500 133-4

Inhalation Exposure – Outdoor 

(Post-Application)

X, Y, Z, BB, 

FF, GG

42968402, 45703703, 

DATA GAP

875.2700 235 Product Use Information X, Y, Z, BB, 

FF, GG DATA GAP

875.2800 133-1 Description of Human Activity X, Y, Z, BB, 

FF, GG DATA GAP

875.2900 134 Data Reporting and Calculations X, Y, Z, BB, 

FF, GG DATA GAP

Special NA Fumigant Buffer Zone Posting 

Signs C, I DATA GAP

Special NA Training for Applicators 

Supervising Fumigations C, I DATA GAP

Special NA Training Material for Handlers C, I DATA GAP