UNITED STATES ENVIRONMENT AL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

DA TE: 04-FEB-2016 

SUBJECT: Triclopyr: Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Proposed Changes to the Tolerances for 

Residues in/on Livestock Commodities. 

PC Codes: I 1600 I, I 16002, I 16004 

Decision No.: 488478 

Petition Nos.: 4F8249 and 4F8279 

Risk Assessment Type: Dietary 

TXR No.: NA 

MRID No.: NA 

OP No.: 0426072 

Registration Nos.: 62719-37, 62719-53, 62719-87, 

62719-552, 62719-637 

Regula tory Action: Section 3 

Case No.: 2710 

CAS Nos.: 55335-06-3, 572 13-69-1 , 64700-56-7 

40 CFR: § 180.417 

REVIEWER: Jennifer R. Tyler, Chemist C~~ ~r--­ Risk Assessment Branch l (RAB I) 

THROUGH: 

TO: 

Executive Summary 

Health Effects Division (HED, 7509P) 

Julie L. Van Alstine, MPH, Envjronmental Health Scientist -YAA-.A----

Seyed Tadayon, Chemist ~~--..... 

Dietary Exposure Science xcfvisory Council (DESAC)!HED (7509P) 

And 

George 

RAB 1/HE

F. 

D 

Kramer, 

(7509P) 

Ph.D., Branch Senior ~~ 

Mindy Ondish, Risk Reviewer 

Reuben Baris, Product Manager 25 

Herbicide Branch (HB) 

Registration Division (RD, 7505P) 

Acute and chronic dietary exposure and risk assessments were conducted for the general U.S. 

population and various population subgroups using the Dietary Exposure Evaluation Model 

software with the Food Commodity Intake Database (DEEM-FCJD) Version 3.16. This software 

uses 2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA's) 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). The analyses were performed to support a petition to remove the grazing 

Page I of 15 
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restriction for lactating dairy cattle, and to amend tolerances of triclopyr on milk and livestock 

commodities. This memorandum was reviewed by two peer reviewers of the DESAC, per 

DESAC SOP 2012.1.

Acute Dietary Exposure Results and Characterization

An acute analysis was performed using DEEM-FCID estimating the dietary exposure of the 

general U.S. population and various population subgroups. The acute assessment was unrefined, 

assuming that triclopyr residues are present in all commodities at tolerance levels and that 100% 

of all crops are treated (100% CT). DEEM Version 7.81 default processing factors were used to 

estimate residues in all processed commodities. Drinking water was incorporated directly into

the dietary assessment. 

For females 13-49 years old, the resulting acute dietary (food and drinking water) risk estimate is

not of concern to HED (<100% acute population-adjusted dose (aPAD)) at the 95th percentile of 

the exposure distribution (53% of the aPAD). For the general U.S. population and all other 

population subgroups, the resulting acute dietary (food and drinking water) risk estimates are not 

of concern to HED (<100% aPAD) at the 95th percentile of the exposure distribution. The most 

highly exposed population subgroup is all infants (<1 year old) at 8% of the aPAD. It should be 

noted that females 13-49 years old have a lower aPAD (0.05 mk/kg/day) than the general U.S. 

population and all other population subgroups (1.0 mg/kg/day). As a result, even though the 

exposure estimate for females 13-49 years old was lower than the exposure estimate for the 

general U.S. population, females 13-49 years old have the highest risk estimate.

Chronic Dietary Exposure Results and Characterization

A chronic analysis was performed using DEEM-FCID estimating the dietary exposure of the 

general U.S. population and various population subgroups. The chronic assessment was slightly 

refined, assuming that triclopyr residues are present in all commodities at tolerance levels except 

milk, and 100% CT for all crops. An anticipated residue (AR) was used for milk. The resulting 

chronic (food and drinking water) risk estimates are not of concern to HED (<100% chronic 

population-adjusted dose (cPAD)) for general U.S. population and all population subgroups. 

The most highly exposed population subgroup is all infants <1 year old at 46% of the cPAD.

Cancer Dietary Exposure Assessment

A cancer dietary assessment was not conducted because triclopyr is classified as a “Group D 

Chemical – unable to be classified as to human carcinogenicity.”

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic (non-cancer) assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no-unreasonable-adversehealth–effects, NOAEL). This dose is referred to as the PAD. The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL) divided by the required uncertainty factors (UFs).

For acute and chronic (non-cancer) exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD for acute and non-cancer chronic assessment. References which 
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discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides 

web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-

JUN-2000, web link http://www.regulations.gov/contentStreamer?documentId=EPA-HQ-OPP2007-0780-0001&disposition=attachment&contentType=pdf; or see SOP 99.6 (20-AUG-1999).

The most recent acute and chronic dietary exposure analyses (food only) were conducted by 

HED in 2002 (Memo, W. Donovan, 16-APR-2002; D275030). 

II. Residue Information

Permanent tolerances are established for the combined residues of triclopyr per se, as a result of 

the application/use of butoxyethyl ester of triclopyr and triethylamine salt of triclopyr, in or on 

eggs; fish; grass forage and hay; milk; poultry fat, meat, and meat byproducts, except kidney; 

rice, grain and straw; and shellfish [40 CFR §180.417 (a)(1)]. In addition, permanent tolerances 

are established for residues of triclopyr acetic acid and its metabolite 3,5,6-trichloro-2-pyridinol 

(TCP), as a result of the application/use of butoxyethyl ester of triclopyr and triethylamine salt of 

triclopyr, in or on the meat, fat, and meat byproducts of cattle, goats, hogs, horses, and sheep [40 

CFR §180.417 (a)(2)].

Residues of Concern in Plants and Livestock

The qualitative nature of the residue in rice, grass, fish, shellfish, and livestock is adequately 

understood based on the available metabolism studies. The residues of concern are as follows 

(Memos, W. Smith, 15-JUL-1996; W. Donovan, 27-APR-2001, D274243): triclopyr per se in 

grass, rice, milk, poultry, and eggs; triclopyr and TCP in meat, meat byproducts, and drinking 

water; and triclopyr, TCP, and 2-methoxy-3,5,6-trichloropyridine (TMP) in fish and shellfish. It 

should be noted that 40 CFR §180.417(a)(1) lists the tolerance expression for fish and shellfish 

as triclopyr per se. 40 CFR §180.417 should be updated to include the recommended tolerance 

expression for fish and shellfish.

Recommended Tolerances

As part of the current petition, HED recommends establishing the following permanent 

tolerances:

Milk1 0.60 ppm

Meat*2 0.10 ppm

Fat*2 0.10 ppm

Meat byproducts*2 0.50 ppm

* of cattle, goat, hog, horse, and sheep.

1 40 CFR §180.417 (a)(1)

2 40 CFR §180.417 (a)(2)

Food Residues and processing factors used in the Acute and Chronic Analysis

The acute analysis assumed DEEM (ver. 7.81) default processing factors and tolerance-level 

residues for all commodities. The chronic analyses assumed DEEM (ver. 7.81) default 

processing factors for all commodities, and tolerance-level residues for all commodities except 

milk. For milk, an anticipated residue was calculated using residues from the recently submitted 

livestock feeding study (MRID# 49741901). In that study the average residue in milk was 0.084
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ppm at the 1000-ppm dose level [0.8x and maximum reasonable dietary burden (MRDB) of 1255 

ppm], which results in an average anticipated residue of 0.10 ppm when extrapolated to 1x. 

III. Percent Crop Treated Information

The acute and chronic analyses assumed that 100% of the crops were treated. 

IV. Drinking Water Data

A revised drinking water assessment was not required since the proposed uses will not have an 

effect on the concentration of triclopyr in drinking water. EFED provided estimated drinking 

water concentrations (EDWCs) for triclopyr based on the registered aquatic use (Memos, L. Liu, 

4-JUN-2015, D419489; M. Mahoney, 17-JUN-2002, D283715). The estimated drinking water 

concentrations (EDWCs) of triclopyr for surface water are estimated to be 1,049 parts per billion 

(ppb) for acute (peak) exposures and 390 ppb for chronic (annual average) exposures. EPA 

calculated and required setback distances from the application site to the functional potable water 

intake in order to maintain average drinking water concentration levels below 400 

ppb. Furthermore, since potable water intakes are required to be turned off until triclopyr 

concentration levels are below 400 ppb, EPA has determined that for acute and chronic dietary 

risk assessments, the water concentration value of 400 ppb is appropriate to use to assess the 

contribution to drinking water.

It should be noted that EDWCs were not incorporated directly in the 2002 dietary exposure 

assessment, but HED calculated drinking water levels of comparison (DWLOCs), which is a 

theoretical upper limit on a pesticide’s concentration in drinking water in light of total aggregate 

exposure to a pesticide in food, drinking water, and through residential uses. In this assessment, 

the EDWC of 400 ppb was incorporated directly in the acute and chronic dietary exposure 

assessments.

V. DEEM-FCID Program and Consumption Information

Triclopyr acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (i.e., apple pie) are 

linked to EPA-defined food commodities (i.e., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2 years 

old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, adults 20-49 years 

old, females 13-49 years old, and adults 50-99 years old.

For the chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (i.e., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 
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estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all levels (tiers) of analysis. However, for unrefined and 

partially refined assessments (Tiers 1 and 2), significant differences in user vs. per capita 

exposure and risk are identified and noted in the risk assessment.

VI. Toxicological Information

The toxicology endpoints and decisions made by the Hazard Identification Assessment Review 

Committee (HIARC) concerning dietary exposure are summarized in Table 1. Based on 

toxicological considerations (evaluated by HIARC) and the residue assumptions used in the 

dietary analyses (evaluated by the risk assessment team; RAB1/HED), it was concluded that the

Food Quality Protection Act (FQPA) Safety Factor should be reduced to 1X when assessing 

dietary exposure to triclopyr. 

Table 1. Summary of Toxicological Doses and Endpoints for Triclopyr for Use in Dietary Exposure Assessments.

Exposure/ 

Scenario POD Uncertainty/FQPA Safety Factors

RfD, PAD, LOC for Risk 

Assessment Study and Toxicological Effects

Acute Dietary

(General 

Population 

including infants 

and children)

NOAEL = 

100 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

aRfD = 1.0 mg/kg/day

aPAD = 1.0 mg/kg/day

Developmental Rat Toxicity Study with ester

Maternal LOAEL = 300 mg/kg/day based on 

mortality, clinical signs, necropsy findings, 

decreased food and water consumption, and 

increased kidney and liver weights.

Acute Dietary

(Females 13-50 

years old)

NOAEL = 5 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

aRfD = 0.05 mg/kg/day

aPAD = 0.05 mg/kg/day

Two-Generation Rat Reproduction Study 

with acid

LOAEL = 25 mg/kg/day based on increased 

incidence of rare malformations 

(exencephaly and ablepharia).

Chronic Dietary

(All Populations)

NOAEL = 5 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

cRfD = 0.05 mg/kg/day

cPAD = 0.05 mg/kg/day

Two-Generation Rat Reproduction Study 

with acid

LOAEL = 25 mg/kg/day based on 

degeneration of the proximal renal tubules. 

Cancer (oral, 

dermal, 

inhalation)

Classified as a “Group D Chemical – unable to be classified as to human carcinogenicity.”

Point of departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning 

of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no-observed adverse-effect level. 

LOAEL = lowest-observed adverse-effect level. UF = uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH =

potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = populationadjusted dose (a = acute, c = chronic). RfD = reference dose. 
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the 

DEEM-FCID (ver. 3.16) acute and chronic exposure analyses.

Acute Dietary Exposure Results

Acute aggregate (food and drinking water) analysis was performed using DEEM-FCID 

estimating the dietary exposure of the general U.S. population and various population subgroups. 

The acute results are summarized in Table 2. For females 13-49 years old, the resulting acute 

(food and drinking water) risk estimates are not of concern to HED (<100% aPAD) at the 95th

percentile of the exposure distribution (53% of the aPAD). For the general U.S. population and 

all other population subgroups, the resulting acute food and drinking water risk estimates are not 

of concern to HED (<100% aPAD) at the 95th percentile of the exposure distribution. The most 

highly exposed population subgroup is all infants (<1 year old) at 8% of the aPAD. It should be 

noted that females 13-49 years old have a lower aPAD (0.05 mg/kg/day) than the general U.S. 

population and all other population subgroups (1.0 mg/kg/day). As a result, even though the 

exposure estimate for females 13-49 years old was lower than the exposure estimate for the 

general U.S. population, females 13-49 years old have the highest risk estimate.

Chronic Dietary Exposure Results

A chronic (food and drinking water) analysis was performed using DEEM-FCID estimating the 

dietary exposure of the general U.S. population and various population subgroups. The chronic 

results are summarized in Table 2. The resulting chronic (food and drinking water) risk

estimates are not of concern to HED (<100% cPAD) for general U.S. population and all 

population subgroups. The most highly exposed population subgroup is all infants <1 year old at 

46% of the cPAD.

Table 2. Summary of Dietary Exposure and Risk for Triclopyr.*

Population Subgroup

Acute Dietary (Food and Drinking 

Water) (95th Percentile)

Chronic Dietary

(Food and Drinking Water)

Dietary Exposure 

(mg/kg/day) % aPAD Dietary Exposure(mg/kg/day) % aPAD

General U.S. Population 0.033198 3.3 0.010008 20

All Infants (<1 year old) 0.080077 8.0 0.023278 46

Children 1-2 years old 0.075543 7.6 0.017810 36

Children 3-5 years old 0.050707 5.1 0.013791 28

Children 6-12 years old 0.034563 3.5 0.009612 19

Youth 13-19 years old 0.025114 2.5 0.007325 15

Adults 20-49 years old 0.026457 2.6 0.009698 19

Adults 50-99 years old 0.024208 2.4 0.009580 19

Females 13-49 years old 0.026561 53 0.009493 19

*Population subgroup with the highest exposure and risk is in bold type. The aPAD for females 13-49 years of age is 0.05 mg/kg/day; aPAD for 

general U.S. population and all other population subgroups is 1.0 mg/kg/day. The cPAD for general U.S. population and all population 

subgroups is 0.05 mg/kg/day.

VIII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure and risk estimates are conservative since they assume 

that 100% of crops are treated with triclopyr and that residues are present at tolerance levels. 

Dietary exposure estimates could be refined through the use of anticipated residues and percent 
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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crop treated data, as well as refined estimated drinking water concentrations. In order to provide 

a comparison for reference, the dietary results for the analysis of food exposures (only) are 

presented in attachments 5 and 6. 

IX. Conclusions

Unrefined acute aggregate (food and drinking water; food only; and drinking water only) 

analyses were performed using DEEM-FCID estimating the dietary exposure of the general U.S. 

population and various population subgroups. For females 13-49 years old, the resulting acute 

(food and drinking water) risk estimates are not of concern to HED (<100% aPAD) at the 95th

percentile of the exposure distribution (53% of the aPAD). For the general U.S. population and 

all other population subgroups, the resulting acute food and drinking water risk estimates are not 

of concern to HED (<100% aPAD) at the 95th percentile of the exposure distribution. The most 

highly exposed population subgroup is all infants (<1 year old) at 8% of the aPAD. 

A slightly refined chronic aggregate (food and drinking water) analysis was performed using 

DEEM-FCID estimating the dietary exposure of the general U.S. population and various 

population subgroups. The resulting chronic (food and drinking water) risk estimates are not of 

concern to HED (<100% cPAD) for general U.S. population and all population subgroups. The 

most highly exposed population subgroup is all infants <1 year old at 46% of the cPAD.

X. List of Attachments

Attachment 1: Acute (Food and Drinking Water) Residue Input File 

Attachment 2: Acute Results (Food and Drinking Water) File

Attachment 3: Chronic Food plus Water Residue Input File 

Attachment 4: Chronic Results (Food plus Water) File

Attachment 5: Acute Results (Food Only) File

Attachment 6: Chronic Results (Food Only) File

cc: J. Tyler

RDI: DE SAC Reviewers (25-FEB-2015); G. Kramer (4-FEB-2016)

J. Tyler:S10943:PY-S:(703)305-5564:7509P:RAB1
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Attachment 1: DEEM-FCID Acute Residue File – Food and Drinking Water

Filename: C:\Users\jtyler\Documents\JenWork\$Triclopyr\Dairies and Choline Salt\Dietary 

Assessment\run with new tolerances\116000 116002 116004 acute.r08

Chemical: Triclopyr

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12-21-2015/10:31:11 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

3100047000 31 Beef, fat 0.100000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.500000 1.000 1.000 

3100049000 31 Beef, liver 0.500000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.500000 1.000 1.000 

3100044000 31 Beef, meat 0.100000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.500000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.500000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 

3100044001 31 Beef, meat-babyfood 0.100000 1.000 1.000 

4000096000 40 Chicken, fat 0.100000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.100000 1.000 1.000 

4000094000 40 Chicken, liver 0.100000 1.000 1.000 

4000093000 40 Chicken, meat 0.100000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.100000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.100000 1.000 1.000 

4000097000 40 Chicken, skin 0.100000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.100000 1.000 1.000 

7000146000 70 Egg, white 0.050000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.050000 1.000 1.000 

7000145000 70 Egg, whole 0.050000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.050000 1.000 1.000 

7000147000 70 Egg, yolk 0.050000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.050000 1.000 1.000 

8000157000 80 Fish-freshwater finfish 3.000000 1.000 1.000 

8000158000 80 Fish-freshwater finfish, farm ra 3.000000 1.000 1.000 

8000160000 80 Fish-saltwater finfish, other 3.000000 1.000 1.000 

8000159000 80 Fish-saltwater finfish, tuna 3.000000 1.000 1.000 

8000161000 80 Fish-shellfish, crustacean 3.500000 1.000 1.000 

8000162000 80 Fish-shellfish, mollusc 3.500000 1.000 1.000 

3200171000 32 Goat, fat 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.500000 1.000 1.000 

3200173000 32 Goat, liver 0.500000 1.000 1.000 

3200169000 32 Goat, meat 0.100000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.500000 1.000 1.000 

3300189000 33 Horse, meat 0.100000 1.000 1.000 

3600222000 36 Milk, fat 0.600000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.600000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.600000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.600000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.600000 1.000 1.000 

3600224000 36 Milk, water 0.600000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.600000 1.000 1.000 

3400293000 34 Pork, fat 0.100000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.100000 1.000 1.000 

3400294000 34 Pork, kidney 0.500000 1.000 1.000 

3400295000 34 Pork, liver 0.500000 1.000 1.000 

3400290000 34 Pork, meat 0.100000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.500000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.500000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.100000 1.000 1.000 

3400291000 34 Pork, skin 0.500000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.100000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.100000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.100000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.100000 1.000 1.000 

1500326000 15 Rice, bran 0.300000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.300000 1.000 1.000 

1500324000 15 Rice, brown 0.300000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.300000 1.000 1.000 
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1500325000 15 Rice, flour 0.300000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.300000 1.000 1.000 

1500323000 15 Rice, white 0.300000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.300000 1.000 1.000 

3500341000 35 Sheep, fat 0.100000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.500000 1.000 1.000 

3500343000 35 Sheep, liver 0.500000 1.000 1.000 

3500339000 35 Sheep, meat 0.100000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.500000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.100000 1.000 1.000 

5000385000 50 Turkey, fat 0.100000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.100000 1.000 1.000 

5000383000 50 Turkey, liver 0.100000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.100000 1.000 1.000 

5000382000 50 Turkey, meat 0.100000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.100000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.100000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.100000 1.000 1.000 

5000386000 50 Turkey, skin 0.100000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.100000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.400000 1.000 1.000 400 pp

 Full comment: 400 ppb EDWC

8602000000 86B Water, indirect, all sources 0.400000 1.000 1.000 400 pp

 Full comment: 400 ppb EDWC
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Attachment 2: DEEM-FCID Acute Exposure Estimates – Food and Drinking Water

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for TRICLOPYR NHANES 2003-2008 2-Day

Residue file: 116000 116002 116004 acute.r08 Adjustment factor #2 used.

Analysis Date: 12-21-2015/10:47:08 Residue file dated: 12-21-2015/10:31:11

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.033198 3.32 0.056512 5.65 0.091412 9.14 

All Infants:

 0.080077 8.01 0.107209 10.72 0.155723 15.57 

Children 1-2:

 0.075543 7.55 0.106053 10.61 0.142313 14.23 

Children 3-5:

 0.050707 5.07 0.069834 6.98 0.093588 9.36 

Children 6-12:

 0.034563 3.46 0.049927 4.99 0.069963 7.00 

Youth 13-19:

 0.025114 2.51 0.036462 3.65 0.053758 5.38 

Adults 20-49:

 0.026457 2.65 0.038240 3.82 0.060328 6.03 

Adults 50-99:

 0.024208 2.42 0.034039 3.40 0.048890 4.89 

Female 13-49:

 0.026561 53.12 0.037113 74.23 0.054370 108.74 
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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Page 11 of 15

Attachment 3: DEEM-FCID Chronic Residue File – Food and Drinking Water

Filename: C:\Users\jtyler\Documents\JenWork\$Triclopyr\Dairies and Choline Salt\Dietary 

Assessment\run with new tolerances\116000 116002 116004 chronic.r08

Chemical: Triclopyr

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-01-2016/14:07:16 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

3100047000 31 Beef, fat 0.100000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.500000 1.000 1.000 

3100049000 31 Beef, liver 0.500000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.500000 1.000 1.000 

3100044000 31 Beef, meat 0.100000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.500000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.500000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 

3100044001 31 Beef, meat-babyfood 0.100000 1.000 1.000 

4000096000 40 Chicken, fat 0.100000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.100000 1.000 1.000 

4000094000 40 Chicken, liver 0.100000 1.000 1.000 

4000093000 40 Chicken, meat 0.100000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.100000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.100000 1.000 1.000 

4000097000 40 Chicken, skin 0.100000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.100000 1.000 1.000 

7000146000 70 Egg, white 0.050000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.050000 1.000 1.000 

7000145000 70 Egg, whole 0.050000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.050000 1.000 1.000 

7000147000 70 Egg, yolk 0.050000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.050000 1.000 1.000 

8000157000 80 Fish-freshwater finfish 3.000000 1.000 1.000 

8000158000 80 Fish-freshwater finfish, farm ra 3.000000 1.000 1.000 

8000160000 80 Fish-saltwater finfish, other 3.000000 1.000 1.000 

8000159000 80 Fish-saltwater finfish, tuna 3.000000 1.000 1.000 

8000161000 80 Fish-shellfish, crustacean 3.500000 1.000 1.000 

8000162000 80 Fish-shellfish, mollusc 3.500000 1.000 1.000 

3200171000 32 Goat, fat 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.500000 1.000 1.000 

3200173000 32 Goat, liver 0.500000 1.000 1.000 

3200169000 32 Goat, meat 0.100000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.500000 1.000 1.000 

3300189000 33 Horse, meat 0.100000 1.000 1.000 

3600222000 36 Milk, fat 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3600222001 36 Milk, fat-baby food/infant formu 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3600223001 36 Milk, nonfat solids-baby food/in 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3600225001 36 Milk, sugar (lactose)-baby food/ 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3600224000 36 Milk, water 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3600224001 36 Milk, water-babyfood/infant form 0.100000 1.000 1.000 AR of 

 Full comment: AR of 0.10 ppm

3400293000 34 Pork, fat 0.100000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.100000 1.000 1.000 

3400294000 34 Pork, kidney 0.500000 1.000 1.000 

3400295000 34 Pork, liver 0.500000 1.000 1.000 

3400290000 34 Pork, meat 0.100000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.500000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.500000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.100000 1.000 1.000 

3400291000 34 Pork, skin 0.500000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.100000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.100000 1.000 1.000 
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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Page 12 of 15

6000301000 60 Poultry, other, meat 0.100000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.100000 1.000 1.000 

1500326000 15 Rice, bran 0.300000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.300000 1.000 1.000 

1500324000 15 Rice, brown 0.300000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.300000 1.000 1.000 

1500325000 15 Rice, flour 0.300000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.300000 1.000 1.000 

1500323000 15 Rice, white 0.300000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.300000 1.000 1.000 

3500341000 35 Sheep, fat 0.100000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.500000 1.000 1.000 

3500343000 35 Sheep, liver 0.500000 1.000 1.000 

3500339000 35 Sheep, meat 0.100000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.500000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.100000 1.000 1.000 

5000385000 50 Turkey, fat 0.100000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.100000 1.000 1.000 

5000383000 50 Turkey, liver 0.100000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.100000 1.000 1.000 

5000382000 50 Turkey, meat 0.100000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.100000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.100000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.100000 1.000 1.000 

5000386000 50 Turkey, skin 0.100000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.100000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.400000 1.000 1.000 400 pp

 Full comment: 400 ppb edwc

8602000000 86B Water, indirect, all sources 0.400000 1.000 1.000 400 pp

 Full comment: 400 ppb edwc
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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Page 13 of 15

Attachment 4: DEEM-FCID Chronic Exposure Estimates – Food and Drinking Water

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for TRICLOPYR NHANES 2003-2008 2-day

Residue file name: C:\Users\jtyler\Documents\JenWork\$Triclopyr\Dairies and Choline Salt\Dietary 

Assessment\run with new tolerances\116000 116002 116004 chronic.r08

 Adjustment factor #2 used.

Analysis Date 02-01-2016/14:32:17 Residue file dated: 02-01-2016/14:23:52

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.010008 20.0%

Hispanic 0.009918 19.8%

Non-Hisp-White 0.010130 20.3%

Non-Hisp-Black 0.008462 16.9%

Non-Hisp-Other 0.012301 24.6%

Nursing Infants 0.008249 16.5%

Non-Nursing Infants 0.029990 60.0%

Female 13+ PREG 0.009246 18.5%

Children 1-6 0.014956 29.9%

Children 7-12 0.009155 18.3%

Male 13-19 0.007077 14.2%

Female 13-19/NP 0.007572 15.1%

Male 20+ 0.009267 18.5%

Female 20+/NP 0.010007 20.0%

Seniors 55+ 0.009389 18.8%

All Infants 0.023278 46.6%

Female 13-50 0.009509 19.0%

Children 1-2 0.017810 35.6%

Children 3-5 0.013791 27.6%

Children 6-12 0.009612 19.2%

Youth 13-19 0.007325 14.7%

Adults 20-49 0.009698 19.4%

Adults 50-99 0.009580 19.2%

Female 13-49 0.009493 19.0%

-------------------------------------------------------------------------------
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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Page 14 of 15

Attachment 5: DEEM-FCID Acute Exposure Estimates – Food Only

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for TRICLOPYR NHANES 2003-2008 2-Day

Residue file: 116000 116002 116004 acute food only.R08

 Adjustment factor #2 used.

Analysis Date: 12-21-2015/10:51:52 Residue file dated: 12-21-2015/10:32:25

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.017471 1.75 0.036882 3.69 0.067615 6.76 

All Infants:

 0.035320 3.53 0.063656 6.37 0.089536 8.95 

Children 1-2:

 0.061033 6.10 0.089754 8.98 0.118422 11.84 

Children 3-5:

 0.033635 3.36 0.048674 4.87 0.079028 7.90 

Children 6-12:

 0.022137 2.21 0.028948 2.89 0.044392 4.44 

Youth 13-19:

 0.012209 1.22 0.018245 1.82 0.029702 2.97 

Adults 20-49:

 0.009399 0.94 0.016229 1.62 0.035900 3.59 

Adults 50-99:

 0.009118 0.91 0.014781 1.48 0.026326 2.63 

Female 13-49:

 0.009251 18.50 0.015412 30.82 0.031373 62.75 
Triclopyr Dietary Exposure and Risk Assessment DP# 426072

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Page 15 of 15

Attachment 6: DEEM-FCID Chronic Exposure Estimates – Food Only

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for TRICLOPYR NHANES 2003-2008 2-day

Residue file name: C:\Users\jtyler\Documents\JenWork\$Triclopyr\Dairies and Choline Salt\Dietary 

Assessment\run with new tolerances\116000 116002 116004 chronic food only.r08

 Adjustment factor #2 used.

Analysis Date 02-01-2016/14:31:25 Residue file dated: 02-01-2016/14:24:57

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001632 3.3%

Hispanic 0.001921 3.8%

Non-Hisp-White 0.001515 3.0%

Non-Hisp-Black 0.001551 3.1%

Non-Hisp-Other 0.002648 5.3%

Nursing Infants 0.000672 1.3%

Non-Nursing Infants 0.002132 4.3%

Female 13+ PREG 0.001360 2.7%

Children 1-6 0.004228 8.5%

Children 7-12 0.002172 4.3%

Male 13-19 0.001319 2.6%

Female 13-19/NP 0.001120 2.2%

Male 20+ 0.001464 2.9%

Female 20+/NP 0.001210 2.4%

Seniors 55+ 0.001291 2.6%

All Infants 0.001681 3.4%

Female 13-50 0.001174 2.3%

Children 1-2 0.005727 11.5%

Children 3-5 0.003612 7.2%

Children 6-12 0.002270 4.5%

Youth 13-19 0.001217 2.4%

Adults 20-49 0.001341 2.7%

Adults 50-99 0.001319 2.6%

Female 13-49 0.001167 2.3%

-------------------------------------------------------------------------------