70268 Federal Register / Vol. 69, No. 232 / Friday, December 3, 2004 / Notices 

using the imaging agent in the detection 

of metastatic disease in the liver is also 

within the scope of the invention. 

E–338–2003—Method for Imaging the 

Lymphatic Systems Using DendrimerBased Contrast Agents 

The invention is a 4D method of 

Magnetic Resonance lymphography 

using a 240kD contract agent based on 

generation-6 polyamidoamine 

dendrimer (G6). The use of the G6 

contrast agent greatly enhances 

visualization of lymphatics and node 

drainage associated with mammary 

tumors and further aids in the diagnosis 

of metastatic breast cancer. After direct 

injection of the G6 contrast agent into 

mice, lymphatics and nodes were 

visualized in both spontaneous (HER2 

transgenic mouse) and xenografted (PT–

18) breast tumors to metastatic lymph 

nodes. The conventional clinically 

approved MRI contract agent, Gd-

[DTPA]-dimeglumine (<1kD) was 

unable (in murine models) to depict 

lymphatics when used in conjunction 

with the same imaging system. The 

invention provides a novel method of 

using a known contrast agent to 

visualize lymphatic drainage that has 

not been previously reported. 

E–317–2004—Synthetic Metal Ion 

Chelating Amino Acid Suitable for Use 

in Solid Phase Peptide Synthesis 

The invention is metal chelators, 

metal chelator-targeting moiety 

complexes, metal chelator-targeting 

moiety-metal conjugates, kits, and 

methods of preparing them. These 

chelators are useful in diagnosing and/

or treatment of cancer and thrombosis. 

The metal chelators may be used in 

conventional synthetic methods to form 

targeting moieties (e.g., peptides, 

proteins, and Starburst polyamidoamine 

dendrimers (PAMAM), capable of 

conjugating diagnostic and/or 

therapeutic metals. The formulae for 

two such chelators is shown below:

The prospective exclusive license will 

be royalty bearing and will comply with 

the terms and conditions of 35 U.S.C. 

209 and 37 CFR 404.7. The prospective 

exclusive license may be granted unless, 

within sixty (60) days from the date of 

this published notice, NIH receives 

written evidence and argument that 

establishes that the grant of the license 

would not be consistent with the 

requirements of 35 U.S.C. 209 and 37 

CFR 404.7. 

Properly filed competing applications 

for a license filed in response to this 

notice will be treated as objections to 

the contemplated license. Comments 

and objections submitted in response to 

this notice will not be made available 

for public inspection, and, to the extent 

permitted by law, will not be released 

under the Freedom of Information Act, 

5 U.S.C. 552.

Dated: November 24, 2004. 

Steven M. Ferguson, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health.

[FR Doc. 04–26595 Filed 12–2–04; 8:45 am] 

BILLING CODE 4140–01–U

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Public Health Service 

National Toxicology Program; National 

Institute of Environmental Health 

Sciences (NIEHS); National Institutes 

of Health (NIH) Notice of Additional 

Data and Analyses for the Assessment 

of the Current Validation Status of In 

Vitro Testing Methods for Identifying 

Potential Ocular Irritants 

Summary 

The National Toxicology Program 

(NTP) Interagency Center for the 


EN03DE04.000</GPH>
Federal Register / Vol. 69, No. 232 / Friday, December 3, 2004 / Notices 70269

Evaluation of Toxicological Methods 

(NICEATM) recently published a notice 

in the Federal Register (Vol. 69, No. 

212, pages 64081–2, November 3, 2004) 

announcing the availability of and 

requesting comments on Background 

Review Documents (BRDs) for four in 

vitro assays proposed for identifying 

potential ocular corrosives and severe 

irritants. Notice is hereby given of the 

availability of additional data and 

analyses for the Hen’s Egg Test-Chorion 

Allantoic Membrane (HET–CAM) assay. 

Copies of the additional analyses and 

any other updates on information 

relevant to this meeting can be obtained 

on the ICCVAM/NICEATM Web site at 

http://iccvam.niehs.nih.gov or by 

contacting NICEATM [NIEHS, P.O. Box 

12233, MD EC–17, Research Triangle 

Park, NC, 27709, (phone) (919) 541–

3398, (fax) (919) 541–0947, (e-mail) 

iccvam@niehs.nih.gov]. 

Interested parties are invited to check 

the ICCVAM/NICEATM Web site 

periodically for additional information 

and/or analyses for this meeting.

Dated: November 23, 2004. 

Samuel H. Wilson, 

Deputy Director, National Institute of 

Environmental Health Sciences.

[FR Doc. 04–26594 Filed 12–2–04; 8:45 am] 

BILLING CODE 4140–01–P

DEPARTMENT OF HOMELAND 

SECURITY 

Coast Guard 

[USCG–2004–18977] 

Collection of Information Under 

Review by Office of Management and 

Budget (OMB): OMB Control Numbers: 

1625–0024, 1625–0044, and 1625–0045

AGENCY: Coast Guard, DHS.

ACTION: Request for comments.

SUMMARY: In compliance with the 

Paperwork Reduction Act of 1995, this 

request for comments announces that 

the Coast Guard has forwarded three 

Information Collection Reports (ICRs)—

(1) 1625–0024, Safety Approval of Cargo 

Containers; (2) 1625–0044, Outer 

Continental Shelf Activities—Title 33 

CFR Subchapter N; and (3) 1625–0045, 

Adequacy Certification for Reception 

Facilities and Advance Notice—33 CFR 

Part 158—abstracted below to the Office 

of Information and Regulatory Affairs 

(OIRA) of the Office of Management and 

Budget (OMB) for review and comment. 

These ICRs describe the information we 

seek to collect from the public. Review 

and comment by OIRA ensures that we 

impose only paperwork burdens 

commensurate with our performance of 

duties.

DATES: Please submit comments on or 

before January 3, 2005.

ADDRESSES: To make sure that your 

comments and related material do not 

enter the docket [USCG–2004–18977] 

more than once, please submit them by 

only one of the following means: 

(1) (a) By mail to the Docket 

Management Facility, U.S. Department 

of Transportation (DOT), room PL–401, 

400 Seventh Street SW., Washington, 

DC 20590–0001. (b) By mail to OIRA, 

725 17th St NW., Washington DC 20503, 

to the attention of the Desk Officer for 

the Coast Guard. 

(2) (a) By delivery to room PL–401 at 

the address given in paragraph (1)(a) 

above, between 9 a.m. and 5 p.m., 

Monday through Friday, except Federal 

holidays. The telephone number is 202–

366–9329. (b) By delivery to OIRA, at 

the address given in paragraph (1)(b) 

above, to the attention of the Desk 

Officer for the Coast Guard. 

(3) By fax to (a) the Facility at 202–

493–2298 and (b) OIRA at 202–395–

6566, or e-mail to OIRA at oiradocket@omb.eop.gov attention: Desk 

Officer for the Coast Guard. 

(4) (a) Electronically through the Web 

Site for the Docket Management System 

at http://dms.dot.gov. (b) OIRA does not 

have a Web site on which you can post 

your comments. 

The Docket Management Facility 

maintains the public docket for this 

notice. Comments and material received 

from the public, as well as documents 

mentioned in this notice as being 

available in the docket, will become part 

of this docket and will be available for 

inspection or copying at room PL–401 

on the Plaza level of the Nassif Building, 

400 Seventh Street SW., Washington, 

DC, between 9 a.m. and 5 p.m., Monday 

through Friday, except Federal holidays. 

You may also find this docket on the 

Internet at http://dms.dot.gov.

Copies of the completed ICRs are 

available through this docket on the 

Internet at http://dms.dot.gov, and also 

from Commandant (CG–611), U.S. Coast 

Guard Headquarters, room 6106 (Attn: 

Mrs. Bernice Parker-Jones), 2100 Second 

Street SW., Washington, DC 20593–

0001. The telephone number is 202–

267–2328.

FOR FURTHER INFORMATION CONTACT: Mrs. 

Bernice Parker-Jones, Office of 

Information Management, 202–267–

2328, for questions on these documents; 

or Ms. Andrea M. Jenkins, Program 

Manager, Docket Operations, 202–366–

0271, for questions on the docket.

SUPPLEMENTARY INFORMATION: 

Public Participation and Request for 

Comments 

We encourage you to participate in 

this request for comment by submitting 

comments and related materials. We 

will post all comments received, 

without change, to http://dms.dot.gov,

and they will include any personal 

information you have provided. We 

have an agreement with DOT to use the 

Docket Management Facility. Please see 

the paragraph on DOT’s ‘‘Privacy Act’’

below. 

Submitting comments: If you submit a 

comment, please include your name and 

address, identify the docket number for 

this request for comment [USCG–2004–

18977], indicate the specific section of 

this document to which each comment 

applies, and give the reason for each 

comment. You may submit your 

comments and material by electronic 

means, mail, fax, or delivery to the 

Docket Management Facility at the 

address under ADDRESSES; but please 

submit them by only one means. If you 

submit them by mail or delivery, submit 

them in an unbound format, no larger 

than 81⁄2 by 11 inches, suitable for 

copying and electronic filing. If you 

submit them by mail and would like to 

know that they reached the Facility, 

please enclose a stamped, self-addressed 

postcard or envelope. We will consider 

all comments and material received 

during the comment period. We may 

change the documents supporting this 

collection of information or even the 

underlying requirements in view of 

them. 

Viewing comments and documents:

To view comments, as well as 

documents mentioned in this notice as 

being available in the docket, go to 

http://dms.dot.gov at any time and 

conduct a simple search using the 

docket number. You may also visit the 

Docket Management Facility in room 

PL–401 on the Plaza level of the Nassif 

Building, 400 Seventh Street, SW., 

Washington, DC, between 9 a.m. and 5 

p.m., Monday through Friday, except 

Federal holidays. 

Privacy Act: Anyone can search the 

electronic form of all comments 

received in dockets by the name of the 

individual submitting the comment (or 

signing the comment, if submitted on 

behalf of an association, business, labor 

union, etc.). You may review the 

Privacy Act Statement of DOT in the 

Federal Register published on April 11, 

2000 (65 FR 19477), or you may visit 

http://dms.dot.gov.

Regulatory History: This request 

constitutes the 30-day notice required 

by OIRA. The Coast Guard has already 

published (69 FR 54300, September 8,