Amendment No. 13 to the Shareholders' Agreement



 Exhibit 10.45 
 AMENDMENT NO. 13 
 TO THE SHAREHOLDERS’ AGREEMENT OF KIRIN-AMGEN, INC. 
 This AMENDMENT NO. 13 TO THE SHAREHOLDERS’ AGREEMENT OF KIRIN-AMGEN, INC., dated as of June 28, 2007 (this “Amendment
Agreement”), which shall become effective at 12:01 A.M., Japan Standard Time, on July 1, 2007, is made and entered into by and among Kirin Brewery Company, Limited, a Japanese corporation to be renamed Kirin Holdings Company, Limited
on July 1, 2007 (“Kirin Holdings”), Kirin Pharma Company, Limited, a Japanese corporation (including any successors by way of merger, consolidation, Share Exchange or similar transaction, “Kirin Pharma”),
Amgen Inc., a Delaware corporation (“Amgen”), and Kirin-Amgen, Inc., a Delaware corporation (“Kirin-Amgen”). All capitalized terms used in this Amendment Agreement and not otherwise defined herein shall have
the meanings assigned to such terms in the Shareholders’ Agreement (defined below), as amended hereby. 
 RECITALS 
 A. Kirin Holdings, Amgen and Kirin-Amgen are parties to that certain Shareholders’ Agreement of Kirin-Amgen, Inc., dated May 11, 1984 (as
amended, the “Shareholders’ Agreement”), and Kirin Holdings and either or both of Amgen and Kirin-Amgen, as the case may be, are parties to certain other agreements listed in Appendix A to this Amendment Agreement (such other
agreements collectively, the “Kirin/Amgen Agreements”); 
 B. Kirin Pharma is a direct, wholly owned subsidiary of Kirin
Holdings; 
 C. The stockholders of Kirin Holdings have approved the effectuation by Kirin Holdings of a reorganization pursuant to which,
among other things, it will assign, convey and transfer to Kirin Pharma all or substantially all of the assets and liabilities relating to Kirin Holdings’ pharmaceuticals business, including all of the shares of capital stock of Kirin-Amgen
held by Kirin Holdings (the “Shares”) and the rights and obligations of Kirin Holdings under the Shareholders’ Agreement as amended hereby and each Kirin/Amgen Agreement, in each case by means of a “Kaisha-Bunkatsu”
effected in accordance with the Corporate Split Agreement listed on Appendix D attached hereto and pursuant to Section 757 of the Japanese Corporation Code (the “Reorganization”); 
 D. Following the Reorganization, Kirin Pharma will continue to be a direct, wholly owned subsidiary of Kirin Holdings; 
 E. The Shareholders’ Agreement and the Kirin/Amgen Agreements contain certain restrictions on Kirin Holdings’ ability to assign to third
parties its rights and obligations under the Kirin/Amgen Agreements; 
 F. Kirin Holdings has requested that Amgen consent to the assignment
by Kirin Holdings to Kirin Pharma of all of the rights and obligations of Kirin Holdings under each Kirin/Amgen Agreement; 







 NOW, THEREFORE, in order to facilitate the Reorganization and at the same time protect their respective
investments in Kirin-Amgen, the parties have agreed as follows: 
  

	1.	CONSENT AND WAIVER; AMENDMENT OF CERTIFICATE OF INCORPORATION; CERTIFICATES OF CORPORATE REGISTRIES; EXCLUSION FROM THE SCOPE OF THE REORGANIZATION 


1.01 Amgen Consent and Waiver 
 Subject to the terms and conditions of this Amendment Agreement, Amgen and Kirin-Amgen each hereby consent to the assignment by Kirin Holdings to Kirin Pharma, pursuant to the Reorganization and in the manner
described in the Reorganization Package, of all of the rights and obligations of Kirin Holdings under each Kirin/Amgen Agreement. 
 1.02
Amendment of Certificate of Incorporation 
 The parties to this Amendment Agreement hereby agree that, in order to
give full effect to Paragraph 17.03 of the Shareholders’ Agreement, as described in Section 2.09 below, the certificate of incorporation of Kirin-Amgen shall be amended and restated as of the date of this Amendment Agreement to conform to
Appendix B attached to this Amendment Agreement. Each Party to this Amendment Agreement shall take all actions and execute and deliver all documents and instruments (including written consents of Kirin Holdings and Amgen in their respective
capacities as stockholders of Kirin-Amgen), and shall cause the members of the board of directors of Kirin-Amgen to adopt all resolutions, take alnl actions and execute and deliver all documents and instruments, reasonably necessary to give full
effect to the provisions of this Section 1.02. 
 1.03 Exclusion from the Scope of the Reorganization 
 In accordance with the last sentence of Article 4(2) of the Corporate Split Agreement listed on Appendix D attached hereto, Kirin Holdings
and Kirin Pharma have discussed the exclusion of the Shares and the rights and obligations of Kirin Holdings under the Shareholders’ Agreement as amended hereby from the scope of the Reorganization and hereby agree that, notwithstanding
anything to the contrary contained in the Corporate Split Agreement, the Shares and the rights and obligations of Kirin Holdings under the Shareholders’ Agreement as amended hereby shall be excluded from the scope of the rights and obligations
being transferred from Kirin Holdings to Kirin Pharma as part of the corporate split contemplated in the Corporate Split Agreement. Notwithstanding anything to the contrary contained herein, the provision in this paragraph shall be governed by and
construed in accordance with the internal laws, and not the law of conflicts, of Japan applicable to agreements made and to be performed in Japan. 
 Kirin Holdings and Kirin Pharma, jointly and severally, represent and warrant to Amgen as of the date hereof that (a) the agreement of Kirin Holdings and Kirin Pharma in the immediately preceding paragraph
constitutes a valid and legally binding agreement of each of Kirin Holdings and Kirin Pharma enforceable against it in accordance with its terms, (b) the agreement of Kirin Holdings and Kirin Pharma in the immediately preceding paragraph
overrides anything to the contrary contained herein or in the Reorganization Package (including 

  

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the Corporate Split Agreement) and (c) by virtue of the agreement of Kirin Holdings and Kirin Pharma in the immediately preceding paragraph, the Shares
and the rights and obligations of Kirin Holdings under the Shareholders’ Agreement as amended hereby will be retained by Kirin Holdings, and will not be transferred to Kirin Pharma, in the Reorganization, notwithstanding anything to the
contrary contained herein or in the Reorganization Package (including the Corporate Split Agreement). 
 1.04 Certificates of Corporate
Registries 
 Each of Kirin Holdings and Kirin Pharma shall deliver to counsel to Amgen at its office in Tokyo true and
complete certificates of their respective corporate registries, issued by a competent registrar office of the Ministry of Justice in Japan and describing the effectuation of the “Kaisha Bunkatsu” in accordance with the Corporate Split
Agreement listed on Appendix D hereto and pursuant to Section 757 of the Japanese Corporation Code, in each case promptly after the same becomes available (and, in any event, within two business days thereof). 
  

	2.	AMENDMENTS TO THE SHAREHOLDERS’ AGREEMENT 

 Effective as of the date of this Amendment Agreement, the Shareholders’ Agreement is hereby amended as follows: 
 2.01 Preamble 
 The Preamble of the Shareholders’ Agreement is amended by
(i) replacing the comma after the word “corporation” in the sixth line with the phrase “to be renamed Kirin Holdings Company and”, (ii) replacing the phrase “1900 Oak Terrace Lane” with the phrase “One
Amgen Center Drive”, and (iii) replacing the phrase “(“Kirin”),” with the phrase “(“Kirin” or “Kirin Holdings”), Kirin Pharma Company, Limited, a Japanese corporation having its principal
office at 26-1, Jingumae 6-chome, Shibuya-ku, Tokyo, Japan 150-8011 (including any successors by way of merger, consolidation, Share Exchange or similar transaction, “Kirin Pharma”),”. 
 2.02 Certain Definitions 
 Paragraph 1 of the Shareholders’ Agreement is amended by inserting (i) in Paragraph 1.10, after the word “Kirin,” in the first and third lines, the phrase “Kirin Pharma,”, (ii) in Paragraph 1.09, in the
place of the word “Kirin”, the phrase “Kirin Pharma” and (iii) after Paragraph 1.10, new Paragraphs 1.11 through 1.33 as follows: 
 1.11 Administrative Matters 
 The term Administrative Matters shall mean any matter
relating to the handling and resolution of intellectual property matters, legal matters and payment of expenses. 
 1.12
Affiliate 
 The term Affiliate shall mean, with respect to any Person, any Person directly or indirectly Controlling,
Controlled by, or under common Control with, such other Person as of the 

  

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date on which, or at any time during the period for which, the determination of affiliation is being made. 
 1.13 Asian Country 
 The term Asian Country shall mean any of the jurisdictions specified in Appendix C attached to this Amendment Agreement, and the term Asian Countries shall mean all such jurisdictions collectively. 
 1.14 Asian Pharma Entity 
 The term Asian Pharma Entity shall mean any corporation that (i) is incorporated or otherwise organized under the laws of, and has its principal executive offices in, any Asian Country; (ii) derives at least
80% of its consolidated revenues from the development, manufacture, processing, distribution or sale of pharmaceutical or biotechnology products in Asian Countries; and (iii) is not Controlled, directly or indirectly, by a Non-Asian Pharma
Entity. 
 1.15 Average Two-Year Trailing Revenues 
 The term Average Two-Year Trailing Revenues with respect to any particular fiscal year shall mean the average of the total revenues and
other income of Corporation, as set forth in the audited annual financial statements of Corporation, for the two immediately preceding fiscal years. 
 1.16 Beneficial Owner 
 The term Beneficial Owner shall mean, with respect to any
Equity Securities, any Person who, directly or indirectly, through any contract, arrangement, understanding, relationship, or otherwise has or shares (i) voting power, which includes the power to vote, or to direct the voting of, such Equity
Security; and/or (ii) investment power, which includes the power to dispose, or to direct the disposition of, such Equity Securities. The terms Beneficially Owned and Beneficial Ownership shall have corresponding meanings. In any dispute
between Amgen and Kirin concerning whether or not a Person who is not a record holder of Equity Securities is nonetheless a Beneficial Owner of such Equity Securities, Amgen shall have the burden of proving that such Person is a Beneficial Owner.

 1.17 Consumer Price Index 
 The term Consumer Price Index shall mean the Consumer Price Index for All Urban Consumers published by the Bureau of Labor Statistics of
the U.S. Department of Commerce, Los Angeles All Items (1982-1984=100), or any successor index thereto, appropriately adjusted. If the Consumer Price Index is converted to a different standard reference base or otherwise revised, then, whenever the
determination of a Consumer Price Index figure is called for herein, the Consumer Price Index shall be converted in accordance with the conversion factors published by the U.S. Department of Commerce, Bureau of Labor Statistics, or, if such Bureau
does not publish such conversion factors, the conversion factors published by any other nationally recognized publisher of similar statistical information determined by Amgen. 
  

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 1.18 Control 
 The term Control, as used with respect to any Person, shall mean the possession, directly or indirectly, of the power to direct or cause
the direction of the management policies of such Person, whether through the ownership of voting securities or by contract or otherwise. The phrases Controlled by and under common Control with shall have corresponding meanings. 
 1.19 Control Event 
 The term Control Event shall mean any of the following: (i) the first date on which the shares of common stock of Kirin Pharma held of record by Kirin Holdings of which Kirin Holdings is a Beneficial Owner cease
to constitute at least 2/3 (two thirds) of the total number of shares of common stock of Kirin Pharma on a fully diluted basis or cease to represent at least 2/3 (two thirds) of the votes entitled to be cast on any matter by holders of Equity
Securities of Kirin Pharma; provided that, in the event but only in the event that Kirin Pharma consummates a Qualified Public Merger or Qualified Public Offering, as of and from the time of such consummation this clause (i) shall automatically
be amended to replace each of the two instances of the phrase “2/3 (two thirds)” above (but not the instance of that phrase below) with the phrase “a majority”; provided, further, that, if Kirin Holdings acquires a majority of
the outstanding Equity Securities of a corporation (a majority of the Equity Securities of which corporation are listed for trading on a recognized national or international securities exchange) (“Target”) and concurrently therewith
or thereafter contributes all of the outstanding common stock of Kirin Pharma to the Target with the result that all of the outstanding common stock of Kirin Pharma is owned by Target (such a transaction, a “Transitional
Transaction”), then the fact that Kirin Holdings owns of record less than 2/3 of the outstanding common stock of Kirin Pharma shall not constitute a Control Event if (x) the Target holds of record all of the outstanding shares of
common stock of Kirin Pharma, (y) Kirin Holdings holds of record a majority of the outstanding Equity Securities of Target, and (z) within 365 days following Kirin Holdings’ contribution to Target of shares of common stock of Kirin
Pharma, Kirin Pharma is merged into Target in a transaction constituting a Qualified Public Merger, (ii) the first date on which Kirin Holdings ceases to have the ability to elect at least a majority of the members of the board of directors of
Kirin Pharma; provided that, in the event that Kirin Holdings, Kirin Pharma and a Target enter into a Transitional Transaction, the fact that Kirin Holdings ceases to have the direct ability to elect at least a majority of the members of the board
of directors of Kirin Pharma shall not constitute a Control Event if (x) the Target has the ability to elect all of the directors of Kirin Pharma, (y) Kirin Holdings has the ability to elect a majority of the directors of Target, and
(z) within 365 days following Kirin Holdings’ contribution to Target of shares of common stock of Kirin Pharma, Kirin Pharma is merged into Target in a transaction constituting a Qualified Public Merger, (iii) the consummation of any
Restricted Transaction or, if earlier, the public announcement, execution or delivery of any agreement, plan or proposal contemplating any Restricted Transaction, in any such case without the prior written consent of Amgen, or (iv) to the
extent that Kirin Holdings or Kirin Pharma consummates a transaction or series of transactions that, but for the fact that it was entered into with a Qualified Third Party or Non-Pharma Entity, would have constituted a Restricted Transaction, the
first date on which such Qualified Third Party ceases to be an Asian Pharma Entity or such Non-Pharma Entity ceases to be a Non-Pharma Entity. 
  

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 1.20 CPI Adjustment 
 The term CPI Adjustment shall mean an adjustment of the FTE Rate, which shall be made by first multiplying such FTE Rate by the Consumer
Price Index in effect as of the effective date of such adjustment and then dividing the resulting product by the Consumer Price Index in effect as of the later of the date of this Amendment Agreement and the date as of which the FTE Rate was last
adjusted. 
 1.21 Equity Securities 
 The term Equity Securities shall mean, with respect to any Person other than a natural person, any shares of capital stock or other
ownership interests of such Person and the securities convertible into or exchangeable or exercisable for or into any such shares or ownership interests. 
 1.22 FTE Rate 
 The term FTE Rate shall mean the rate used by the Parties to reimburse
Kirin Pharma and Amgen for personnel-related expenses incurred by them in connection with their respective research and development activities. 
 1.23 Group 
 The term Group means any group of Persons acting in concert with respect
to the acquisition, ownership or disposition of Equity Securities. 
 1.24 Kirin-Amgen Matter 
 The term Kirin-Amgen Matter shall mean, collectively, any Administrative Matter, any matter relating to Corporation under consideration by
the primary business representatives of Amgen, on the one hand, and Kirin Holdings or Kirin Pharma, on the other hand, any matter or question required to be decided or acted upon by the Board of Directors or stockholders of Corporation and any
matter requiring the consent of any of the Parties pursuant to this Agreement or any other agreement between or among Amgen, on the one hand, and Kirin Holdings or Kirin Pharma, on the other hand, related to Corporation or to the Products (as
defined in Section 17.04.1). 
 1.25 Non-Asian Pharma Entity 
 The term Non-Asian Pharma Entity shall mean (i) any Person that derives 50% or more of its consolidated revenues from the
development, manufacture, processing, distribution or sale of pharmaceutical or biotechnology products outside of Asian Countries, and (ii) any Person Controlled, directly or indirectly, by any Person described by clause (i) of this
sentence. 
 1.26 Non-Pharma Entity 
 The term Non-Pharma Entity shall mean any Person that (i) derives less than 10% of its consolidated revenues from the development,
manufacture, processing, distribution or sale 

  

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of pharmaceutical or biotechnology products, and (ii) if Controlled, is not Controlled, directly or indirectly, by any Person other than a Person
described by clause (i) of this sentence. 
 1.27 Person 
 The term Person shall mean an individual, a corporation, a partnership, an association, a limited liability company, joint venture,
estate, trust or other entity of any kind or nature. 
 1.28 Purchase Event 
 The term Purchase Event shall mean the first date on which shares of common stock of Kirin Pharma held of record by Kirin Holdings of
which Kirin Holdings is a Beneficial Owner cease to constitute at least [*] of the total number of shares of common stock of Kirin Pharma on a fully diluted basis or cease to represent at least [*] of the votes entitled to be cast on any matter by
holders of Equity Securities of Kirin Pharma; provided that, if Kirin Holdings acquires [*] of the outstanding Equity Securities of Target and concurrently therewith or thereafter consummates a Transitional Transaction, then the fact that Kirin
Holdings owns of record less than [*] of the outstanding common stock of Kirin Pharma shall not constitute a Control Event if (i) Target holds of record [*] of the outstanding shares of common stock of Kirin Pharma, (ii) Kirin Holdings
holds of record [*] of the outstanding Equity Securities of Target, and (iii) within [*] days following Kirin Holdings’ contribution to Target of shares of common stock of Kirin Pharma, Kirin Pharma is merged into Target in a transaction
constituting a Qualified Public Merger. 
 1.29 Qualified Public Merger 
 The term Qualified Public Merger shall mean any merger, consolidation or Share Exchange of Kirin Pharma with or into any other corporation
(a majority of the Equity Securities of which corporation are listed for trading on a recognized national or international securities exchange) after the consummation of which merger, consolidation or Share Exchange at least 30% but less than 50% of
the total number of shares of common stock of Kirin Pharma, calculated on a fully diluted basis, are listed for trading on a recognized national or international securities exchange; provided, however that after the consummation of a Qualified
Public Merger (other than Share Exchange) in which Kirin Pharma is not the surviving corporation, all references to shares of common stock of Kirin Pharma herein shall be deemed to be references to shares of common stock of such surviving
corporation. 
 1.30 Qualified Public Offering 
 The term Qualified Public Offering shall mean a public offering, registered under the Securities and Exchange Law of Japan and conducted
on a “firm commitment” basis for an aggregate offering price of not less than ¥5 billion, of shares of common stock of Kirin Pharma that upon completion of such offering will be listed on the Tokyo Stock Exchange and will represent at
least 30% but less than 50% of the total number of shares of common stock of Kirin Pharma on a fully diluted basis.
  

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 1.31 Qualified Third Party 
 The term Qualified Third Party shall mean any Asian Pharma Entity that is not making or asserting and, within the past five years, has not
made or asserted, against Amgen or any of its Affiliates or any of their significant subsidiaries, in any written communication, action, suit, proceeding or arbitration, any claim which, if resolved other than in Amgen’s favor, could materially
and adversely affect the business, assets, business relationships, prospects, financial condition or results of operations of Amgen or any such Affiliate or significant subsidiary. 
 1.32 Restricted Transaction 
 The term Restricted Transaction shall mean any transaction or series of transactions (including but not limited to any issuance, sale, transfer, assignment, pledge, hypothecation or other disposition or encumbrance of
securities or other assets or property, and any merger, consolidation, Share Exchange, reorganization, recapitalization or reverse stock split) as a result of which any Person or Group (other than Kirin Holdings or an employee of Kirin Pharma)
(i) is or will become the Beneficial Owner of (A) any Equity Securities of Kirin Pharma and such Beneficial Ownership could affect the management or business of Corporation, or (B) any Equity Securities of Corporation, or
(ii) possesses or will possess the right to appoint one or more members of the board of directors of (A) Kirin Pharma, where the existence or exercise of such rights could affect the management or business of Corporation, or
(B) Corporation, other than any (v) issuance, sale or transfer of Equity Securities of Kirin Holdings to any Qualified Third Party or Non-Pharma Entity, (w) merger, consolidation, Share Exchange or similar business combination
transaction between Kirin Holdings, on the one hand, and any Qualified Third Party or Non-Pharma Entity, on the other, (x) Qualified Public Merger, or (y) Qualified Public Offering, or (z) Transitional Transaction in which
(I) the Target holds of record all of the outstanding shares of common stock of Kirin Pharma, (II) Kirin Holdings holds of record a majority of the outstanding Equity Securities of Target, (III) the Target has the ability to elect all of the
directors of Kirin Pharma, (IV) Kirin Holdings has the ability to elect a majority of the directors of Target, and (V) within 365 days following Kirin Holdings’ contribution to Target of shares of common stock of Kirin Pharma, Kirin Pharma
is merged into Target in a transaction constituting a Qualified Public Merger. 
 1.33 Share Exchange 
 The term Share Exchange shall mean a kabushiki-kokan or kabushiki-iten, as those terms are currently construed under the
Japanese Corporation Code. 
 2.03 Qualification of Board Members 
 Paragraph 12.01 of the Shareholders’ Agreement is amended by inserting after the second sentence thereof, the following sentence:
“Each member of the Board of Directors of Corporation (and each candidate therefor nominated by Kirin or Amgen) shall be an employee of Kirin or one of its subsidiaries or Amgen or one of its subsidiaries, as the case may be.” 

2.04 Shareholder Consultation 
 Paragraph 12 of the Shareholders’ Agreement is amended by inserting, after Paragraph 12.03, Paragraphs 12.03A and 12.03B as follows: 
  


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 “12.03A Administrative Decision-Making 
 The Parties shall cause all Administrative Matters to be handled in a manner consistent with their respective past practices. 

12.03B Decision Deadlocks 
 12.03B.1 If, with respect to any Kirin-Amgen Matter, the representatives of the applicable Parties are unable to reach agreement within [*] calendar days following the date on which such Kirin-Amgen Matter is first
notified by one Party to the other Party, then either such Party shall be entitled to implement the consultation process contemplated by this Paragraph by giving written notice to the other Party (each, an “Escalation Notice”).

 12.03B.2 Within [*] calendar days following receipt of an Escalation Notice, the applicable Parties shall cause such
Kirin-Amgen Matter to be referred to the President and the Chairman of Corporation (or such designees who have decision-making authority with respect to such Kirin-Amgen Matter), and the applicable Parties shall cooperate to cause such President and
Chairman (or their designees) to resolve such disagreement in good faith within [*] calendar days following the date of the related Escalation Notice. 
 12.03B.3 If the President and the Chairman of Corporation are unable to reach agreement on such Kirin-Amgen Matter during such period, the applicable Parties shall cause such Kirin-Amgen Matter to be referred to the
attendees of Kirin and Amgen at the first succeeding executive business meeting of Corporation and the applicable Parties shall cooperate to cause such attendees to resolve such disagreement in good faith at such executive business meeting.

 12.03B.4 If such attendees are unable to resolve such disagreement at such meeting, within [*] calendar days following such
meeting, the applicable Parties shall cause such Kirin-Amgen Matter to be referred to the respective Chief Executive Officers of Kirin and Amgen, and the applicable Parties shall cooperate to cause such Chief Executive Officers to resolve such
disagreement in good faith within [*] calendar days following the date of the preceding executive business meeting. 
 12.03B.5 If the authorized representatives of the applicable Parties reach agreement with respect to such Kirin-Amgen Matter pursuant to this Paragraph, Kirin and Amgen shall take such actions as are necessary to cause Corporation to
implement such decision. If the Chief Executive Officers of Kirin and Amgen are unable to reach agreement on such Kirin-Amgen Matter, neither Corporation nor its Board of Directors or Officers shall be required to take any action in connection
therewith.” 
 2.05 Management 
 (a) Paragraph 12.06 of the Shareholders’ Agreement is amended by replacing the phrase “Kirin and/or Amgen” in the seventh line thereof with the phrase “any of the Parties”. 
 (b) Paragraph 12.07 of the Shareholders’ Agreement is amended by replacing the phrase “Kirin and/or Amgen” in the fourth
line thereof with the phrase “any of the Parties”. 
  

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 (c) Paragraph 12.10 of the Shareholders’ Agreement is amended by inserting, after
the word “Kirin”, the phrase “, Kirin Pharma”. 
 2.06 Business Matter 
 (a) Paragraph 13.01 of the Shareholders’ Agreement is amended by (i) replacing the phrase “Kirin and Amgen” in the
second line thereof with the phrase “the Parties”, and (ii) replacing the word “Kirin” in the first line of clause (i), and the second, fifth and eleventh lines of clause (iii) with the phrase “Kirin Pharma”.

 (b) Paragraphs 13.02 and 13.03 of the Shareholders’ Agreement are amended by replacing each instance of the word
“Kirin” with the phrase “Kirin Pharma”. 
 2.07 Restrictions on Shares 
 (a) Paragraph 14.01 of the Shareholders Agreement is amended by deleting the words “in any other way dispose of or” and “,
voluntarily and involuntarily, by bankruptcy, operation of law or otherwise” in the sixth through eighth lines thereof. 
 (b) Paragraph 14.02 of the Shareholders’ Agreement is deleted in its entirety. 
 (c) Paragraphs 14.03 and 14.04
of the Shareholders’ Agreement are amended and restated as follows: 
 “14.03 Purchase Price 
 For purposes of Paragraphs 14.01 above and 17.04 below, the “Purchase Price” to be paid for the shares (the
“Purchase Shares”) of the transferring shareholder (the “Transferor”) shall be as follows: 
 (i) The Purchase Price shall be [*], and shall be determined in United States dollars as of a date not later than [*] calendar days following the date of the notice in writing (each, an “Exercise Notice”) provided by the
Nontransferring Shareholder or Amgen, as the case may be (the “Transferee”), pursuant to Paragraph 14.03 or 17.04, as the case may be; provided that, if such determination is made by [*] in accordance with Paragraph 14.03(ii),
such determination shall be made as of the month preceding the date on which such [*] is made. 
 (ii) The Purchase Price
shall be determined, if possible, by the mutual agreement of the Transferor and Transferee in accordance with the definition set forth in Paragraph 14.03(i). If Transferor and Transferee are unable to reach agreement within [*] calendar days
following the date of the Exercise Notice, the Purchase Price shall be determined by [*]. If Transferor and Transferee are unable to [*], each shall choose [*] and the [*] shall, in good faith, select [*]. The [*] so selected shall determine the
Purchase Price, which determination shall be final and binding on Transferor and Transferee. If either Transferor or Transferee fail to select [*] within [*] calendar days after receipt of notice from the other Party specifying such failure, such
other Party may select [*] in its sole discretion to determine the Purchase Price, which determination shall be final and binding on Transferor and Transferee. Transferor and Transferee shall instruct the [*] so retained to deliver a written opinion
as to the Purchase Price to each of them within [*] 

  

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calendar days following the selection of the [*]. The cost of determining the Purchase Price, including the fees and expenses of the [*], shall, unless
otherwise agreed by Transferor and Transferee in writing, be borne [*]. 
 (iii) Corporation agrees to furnish the [*]
retained pursuant to Paragraph 14.03(ii) with such financial, business or other information as is reasonably necessary to allow it to evaluate the business, financial condition and results of operations of Corporation, subject to execution of a
reasonable confidentiality agreement between Corporation and such [*]. 
 14.04 Purchase Closing 
 (i) The consummation of the purchase and sale of the Purchase Shares (the
“Purchase Closing”) shall occur on the 15th calendar day (or, if such 15th calendar day is not a business day, the next succeeding business day) following the last to occur of (i) the final determination of the Purchase Price, and (ii) the receipt of any governmental and
regulatory approvals required for the consummation of the Purchase Closing, at 10:00 a.m., California time, at the principal executive office of Transferee. At the Purchase Closing, the Transferor shall deliver to Corporation a share certificate or
share certificates evidencing the Purchase Shares, endorsed for transfer to the Transferee, and a notice of transfer sufficient to effect the transfer of the Purchase Shares to the Transferee, and the Transferee shall deliver the Purchase Price to
the Transferor in cash, by wire transfer or by certified or official bank check, in any case denominated in United States dollars, and the transfer of the ownership of the Purchase Shares shall be duly recorded in the share register of Corporation.

 (ii) The consummation of such transaction shall constitute (i) a warranty by the Transferor to the
Transferee that, as of the Purchase Closing, all such Purchase Shares shall be duly authorized, validly issued and fully paid and that the sale and delivery of the Purchase Shares at the Purchase Closing shall vest in the Transferee good legal title
and beneficial ownership of the Purchase Shares, free and clear of all liens, charges, encumbrances, usufructs, restrictions, options and other claims, and (ii) an agreement by the Transferee to indemnify the Transferor and hold it harmless
against any losses or damages arising out of the foregoing warranty.” 
 2.08 Endorsement of Certificates 
 Section 16 of the Shareholders’ Agreement is amended by replacing the word “Kirin” with the phrase “Kirin
Holdings, Kirin Pharma”. 
 2.09 Additional Provisions 
 Section 17 of the Shareholders’ Agreement is amended and restated as follows: 
 “17. ADDITIONAL PROVISIONS 
 17.01 Restricted Transactions 
 Neither Kirin nor Kirin Pharma shall, without the
prior written consent of Amgen, consummate, publicly announce, execute or deliver any agreement, plan or proposal 

  

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contemplating any Restricted Transaction or take or permit any action or suffer to exist any event, condition or circumstance that is reasonably likely to
result in any Restricted Transaction. 
 17.02 Control Event 
 Kirin shall provide Amgen with confidential written notice (containing, with respect to an event referred to in clause (a), a reasonably
detailed description of the proposed agreement or transaction) of (a) its expected entry into any agreement or transaction providing for a Control Event, not later than [*] calendar days prior to entering into such agreement or transaction, and
(b) the occurrence of a Control Event within [*] calendar days following such occurrence. Upon the occurrence of a Control Event: 
 17.02.1 Corporation shall at Amgen’s option, which it may exercise by giving written notice thereof at any time on or prior to the [*] calendar day following its receipt of notice of the occurrence of such
Control Event, immediately issue and deliver to Amgen one share of preferred stock having the terms set forth in Article Fifth of Corporation’s Amended and Restated Certificate of Incorporation to be filed on or about June 29, 2007 (such
share, the “Control Share” and such Amended and Restated Certificate of Incorporation, the “Restated Charter”), and Amgen shall promptly pay to Corporation, against the delivery thereof, the par value thereof.
Amgen, Kirin Holdings and Kirin Pharma hereby irrevocably consent to such issuance of the Control Share in accordance with Paragraph 2.13.1. 
 17.02.2 Upon the issuance to Amgen of one share of preferred stock of Corporation pursuant to Paragraph 17.02.1, the number of members of the Board of Directors of Corporation shall automatically increase to seven
directors pursuant to Article Eighth of the Restated Charter, and Amgen, in its capacity as holder of all of the outstanding shares of preferred stock, shall promptly nominate, designate and elect the member of the board of directors of Corporation
entitled to be nominated, designated and elected by holders of such shares pursuant to paragraph (a) of Article Fifth of the Restated Charter. 
 17.02.3 Each Party shall take all actions, and execute and deliver all documents and instruments, reasonably necessary to give full effect to the provisions of this Paragraph 17.02 and the Restated Charter.

 17.03 Purchase Event 
 Kirin shall provide Amgen with confidential written notice (containing, with respect to an event referred to in clause (a), a reasonably detailed description of the proposed agreement or transaction) of (a) its
expected entry into any agreement or transaction providing for a Purchase Event, not later than [*] calendar days prior to entering into such agreement or transaction, and (b) the occurrence of a Purchase Event within [*] calendar days
following such occurrence. Such notice shall be deemed given when such notice is received. 
 Upon the occurrence of a
Purchase Event, (i) Amgen shall have the option, which it may exercise by giving written notice thereof to Kirin and Corporation at any time on or prior to the [*] calendar day following its receipt of notice of the occurrence of such Purchase
Event, to elect to purchase [*] of the Equity Securities of Corporation held by Kirin (the “Kirin Shares”) in accordance with Paragraphs 14.03 and 14.04, as amended, and (ii) the Corporation shall be 

  

 12 








 
entitled to, and Amgen may (by written notice given, in its sole discretion, on Corporation’s behalf), at any time following such occurrence, terminate
any or all of the agreements between Corporation, on the one hand, and Kirin and/or Kirin Pharma, on the other hand, including any or all of the Kirin/Amgen Agreements, and each such agreement is hereby amended to so provide. 
 17.04 R&D Funding & Reimbursement Obligations 
 17.04.1 Corporation shall, and Kirin and Amgen shall cooperate to cause Corporation to, (i) authorize Amgen to incur expenses on
Corporation’s behalf, in each calendar year specified in the table below, in respect of research and development activities conducted by Amgen in relation to indications presented to the Board of Directors of Corporation prior to July 1,
2007 of any of [*] (each as defined in the applicable amendment to this Agreement and the related agreements between or among one or more of the Parties and, collectively, the “Products”), up to at least the aggregate expense amount
set forth opposite such calendar year in the second column of the table below, and (ii) authorize Kirin Pharma to incur expenses on Corporation’s behalf, in each calendar year specified in the table below, in respect of research and
development activities conducted by Kirin Pharma in relation to such indications of the Products, up to at least the aggregate expense amount set forth opposite such calendar year in the third column of the table below. Corporation shall account for
such authorized expenses in accordance with U.S. generally accepted accounting principles and shall reimburse Amgen and Kirin Pharma therefor in accordance with past practice. Each such aggregate expense amount shall be allocated among Amgen’s
or Kirin Pharma’s research and development activities relating to such indications of the Products in a manner determined by Amgen or Kirin Pharma, as the case may be, in its sole discretion, and each such Party shall provide Corporation with
reasonable notice of such allocation. 
  

					
	 Year
	  	Amgen 
Aggregate
Expense Amount	 	Kirin Pharma
Aggregate
Expense Amount
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]

 Any expenses that Amgen or Kirin Pharma incurs on behalf of Corporation in respect
of research and development activities relating to such indications of the Products that are in excess of such aggregate expense amount shall require the approval of the Board of Directors of Corporation. Notwithstanding anything to the contrary
herein, [*]. 
 17.04.2 Corporation shall, and Kirin and Amgen shall cooperate to cause Corporation to, authorize each of
Kirin Pharma and Amgen to incur expenses on Corporation’s behalf, in each calendar year from [*] through 2019, in respect of research and development activities conducted by Kirin Pharma and/or Amgen in relation to the Products, up to at least
an aggregate expense amount equal to [*] of the [*] of Corporation applicable to such calendar year. Corporation shall account for such authorized expenses in accordance with U.S. generally accepted accounting principles and shall reimburse Kirin
Pharma and/or Amgen therefor in accordance with past practice. Each such aggregate expense amount shall be allocated among Kirin Pharma’s and Amgen’s respective research and development activities relating to the 

  

 13 








 
Products in a manner determined by the Board of Directors of Corporation in its sole discretion. In the event that the Board of Directors of Corporation is
unable to reach agreement on such allocation, the applicable aggregate expense amount shall be allocated among Kirin Pharma and Amgen’s respective research and development activities in proportion to the previous year’s allocation.

 17.04.3 If at any time the revenue of Corporation, together with any cash on hand, is insufficient to fund the payment
obligations of Corporation under this Paragraph 17.04, then Kirin and Amgen shall make capital contributions to Corporation, ratably according to the number of shares of common stock of Corporation held by each of them, in an aggregate amount equal
to the amount by which such payment obligation exceeds such income and cash on hand and otherwise in accordance with Paragraph 2.13. Each of Kirin and Amgen shall have the right to deduct from any amounts (including royalties) owed by such Party to
Corporation pursuant to any agreement between such Party and Corporation any unpaid amounts required to be paid by Corporation pursuant to this Paragraph 17.04. 
 17.05 FTE Rates 
 Corporation agrees, and Kirin and Amgen agree to cause Corporation to, adjust the FTE Rate by means of a CPI Adjustment effective as of January 1 of each calendar year; provided that, unless otherwise agreed by
Kirin and Amgen in writing, in no event shall any FTE Rate be reduced to an amount less than the prior year’s FTE Rate.” 
 2.10
Export Control Laws 
 Paragraph 19.02 of the Shareholders’ Agreement is amended by replacing the word
“Kirin” with the phrase “Kirin Pharma”. 
 2.11 Entire Agreement; Amendment 
 Paragraph 22.03 of the Shareholders’ Agreement is amended by replacing the phrase “Kirin, Amgen and the Corporation” in the
second sentence thereof with the phrase “each Party”. 
 2.12 Notices 
 Paragraph 22.01 of the Shareholders’ Agreement is amended and restated as follows: 
 “All notices, requests, demands and other communications required or permitted to be given under this Agreement shall be in writing
and shall be addressed to the following: 
  

 14 









			
	 “Kirin Holdings”
	  	Kirin Holdings Company, Limited
		  	10-1, Shinkawa 2-chome, Chuo-ku
		  	Tokyo, 104-8288, Japan
		
		  	Attention: General Manager, Corporate Planning Department
		  	Facsimile No.: +81-3-5540-3587
		  	Telephone No.: +81-3-5540-3424
		
	 “Kirin Pharma”
	  	Kirin Pharma Company, Limited
		  	26-1, Jingumae 6-chome, Shibuya-ku
		  	Tokyo, 150-8011, Japan
		
		  	Attention: General Manager, Planning Department
		  	Facsimile No.: +81-3-5485-6301
		  	Telephone No.: +81-3-5485-6765
		
	 “Amgen”
	  	Amgen Inc.
		  	One Amgen Center Drive
		  	Thousand Oaks, California 91320-1799, United States
		  	Attention: General Counsel
		  	Facsimile No.: +1-805-499-6751
		  	Telephone No.: +1-805-447-1000
		
	 “Corporation”
	  	Kirin-Amgen, Inc.
		  	c/o Amgen Inc.
		  	One Amgen Center Drive
		  	Thousand Oaks, California 91320-1799, United States
		
		  	Attention: President of Kirin-Amgen
		  	Facsimile No.: +1-805-499-6751
		  	Telephone No.: +1-805-447-1000

 Either Party may change its address to which notices shall be sent by giving notice to the other Party in the
manner herein provided. Any notice required or provided for by the terms of this Agreement shall be in writing and shall be (a) sent by means of “next day” air express delivery via a reputable international overnight courier service,
or (b) sent by facsimile transmission, in each case properly addressed in accordance with the paragraph above. The effective date of notice shall be the actual date of receipt by the Party receiving the same.” 
 2.13 Publicity and Disclosure 
 Paragraph 22.02 of the Shareholders’ Agreement is amended and restated as follows: 
 “22.02
Confidential Information; Disclosure and Publicity 
 22.02.1 Each Party agrees not to, and agrees to cause such
Party’s directors, 

  

 15 








 
officers, employees, etc. not to, disclose or permit the disclosure to any third party of any confidential, non-public or proprietary information relating to
the business of Corporation or any other Party (collectively, “Confidential Information”); provided that such disclosure may be made (i) with the prior written consent of Kirin and Amgen, (ii) to any Person who is a
director, officer, employee, attorney, agent, consultant or accountant of a Party who needs to know such information for the purposes of this Agreement and in connection with the conduct of the business of Corporation, and agrees to be bound by such
Party’s confidentiality obligations hereunder, (iii) subject to Paragraph 22.02.2, pursuant to a subpoena or order issued by a court, arbitrator or governmental body, agency or official, or (iv) subject to Paragraph 22.02.3, to the
extent required by applicable law or by the rules of any securities exchange. 
 22.02.2 In the event that a Party or any of
its Affiliates is required to disclose any Confidential Information in connection with any judicial or administrative proceedings (by oral questions, interrogatories, requests for information or documents, subpoena, civil investigation demand or
similar process), that Party in advance of such disclosure shall provide the other Parties with prompt notice of such requirement(s). Such Party also agrees, to the extent legally permissible, to provide the other Parties, in advance of any such
disclosure, with a list of any Confidential Information it intends to disclose (and, if applicable, the text of the disclosure language itself) and to cooperate with the other Parties to the extent they may seek to limit such disclosure, including,
if requested, taking all reasonable steps to resist or avoid any such judicial or administrative proceeding referred to above. If, in the absence of a protective order or the receipt of a waiver from the other Parties after a request in writing
therefor is made by such Party (such request to be made as soon as practicable to allow the other Parties a reasonable amount of time to respond thereto), such Party or any of its Affiliates is legally required to disclose the Confidential
Information to any tribunal to avoid censure or penalty, such Party may disclose such information without liability hereunder. 
 22.02.3 No Party shall issue or publish any press release or other public communication about Corporation or its business without the express written consent of the other Party, except to the extent such public communication is required by
applicable law or by the rules of any securities exchange; provided that, to the extent practicable, such Party shall provide notice to and consult with the other Party on the content of such communication.” 
 2.14 Expansion of Business 
 Paragraph 22.19 of the Shareholders’ Agreement is amended by replacing the phrase “Amgen or Kirin” with the phrase “any of the Parties”. 
  

	3.	REPRESENTATIONS AND WARRANTIES 

 3.01
Representations and Warranties of Kirin Holdings and Kirin Pharma 
 To induce Amgen to enter into and perform this
Agreement, Kirin Holdings and Kirin Pharma (collectively, the “Kirin Parties”), jointly and severally, represent and warrant to Amgen as of the date hereof as follows: 
 (a) Kirin Pharma is a corporation duly organized and validly existing and in good standing under the laws of the country of Japan and has
all requisite power and authority to 

  

 16 








 
lawfully carry on its business as now being conducted and to make, execute, deliver and perform this Amendment Agreement. All of the outstanding Equity
Securities of Kirin Pharma are held of record and beneficially by Kirin Holdings. 
 (b) This Amendment Agreement has
been duly authorized and has been approved by all necessary corporate action of each Kirin Party. This Amendment Agreement has been duly executed and delivered by each Kirin Party and constitutes a valid and legally binding obligation of each Kirin
Party, enforceable against each Kirin Party in accordance with its terms. 
 (c) Neither execution or delivery of this
Amendment Agreement nor its performance by each Kirin Party will, with or without notice, lapse of time or both, (i) conflict with, violate or result in a breach of any term, condition or provision of, nor constitute a material default under,
or result in the acceleration of any material obligation under, or permit the termination of any indenture, material contract or other material agreement to which a Kirin Party is a party or by which a Kirin Party or its properties is subject or
bound; (ii) conflict with or violate the provisions of any judgment, decree or order to which such Kirin Party is subject or such Kirin Party’s registry certificate, articles of association or comparable governing documents, or to the best
of each Kirin Party’s knowledge, any law or regulation; or (iii) result in the creation or acceleration of any obligations under any lien, charge, pledge, security interest, claim or other encumbrance on any of the assets of any Kirin
Party or any of its subsidiaries. 
 (d) Neither Kirin Party is a party to any pending or threatened suit, action or legal,
administrative, arbitration or other proceeding which might materially and adversely affect the transactions contemplated by this Amendment Agreement, nor does either Kirin Party know of any facts which are likely with the passage of time to give
rise to such a suit, action or proceeding. 
 (e) No notices, reports or filings are required to be made by any Kirin Party
with, nor are any consents, registrations, approvals, permits or authorizations required to be obtained by any Kirin Party from, any domestic or foreign governmental or regulatory authority, agency, commission, body, court or other legislative,
executive or judicial governmental entity (each, a “Governmental Entity”), in connection with the execution, delivery and performance of this Amendment Agreement by any of the parties hereto. 
 (f) Kirin Holdings and Kirin Pharma have provided Amgen with the documentation listed on Appendix D to this Agreement (the
“Reorganization Package”), pertaining to the Reorganization and the assignment, conveyance and transfer of the rights and obligations of Kirin Holdings under each Kirin/Amgen Agreement. The documentation comprising the
Reorganization Package is true, accurate and complete, and describes the Reorganization in all material respects. The Reorganization Package does not contain any untrue statement of a material fact, or omit to state a material fact necessary to make
the statements or facts contained herein or therein not misleading. The Reorganization will be effected in accordance with the Reorganization Package. 
 3.02 Representations and Warranties of Amgen 
 To induce the Kirin Parties to enter
into this Agreement, Amgen represents and 

  

 17 








 
warrants to Kirin Holdings and Kirin Pharma as of the date hereof as follows: 
 (a) This Amendment Agreement has been duly authorized and has been approved by all necessary corporate action of Amgen. This Amendment
Agreement has been duly executed and delivered and constitutes a valid and legally binding obligation of Amgen, enforceable against Amgen in accordance with its terms. 
 (b) Neither execution or delivery of this Amendment Agreement nor its performance by Amgen will, with or without notice, lapse of time or
both, (i) conflict with, violate or result in a breach of any term, condition or provision of, nor constitute a material default under, or result in the acceleration of any material obligation under, or permit the termination of any indenture,
material contract or other material agreement to which Amgen is a party or by which Amgen or its properties is subject or bound; (ii) conflict with or violate the provisions of any judgment, decree or order to which Amgen is subject or
Amgen’s certificate of incorporation, bylaws or comparable governing documents, or to the best of Amgen’s knowledge, any law or regulation; or (iii) result in the creation or acceleration of any obligations under any lien, charge,
pledge, security interest, claim or other encumbrance on any of the assets of Amgen or any of its subsidiaries. 
 (c) Amgen
is not a party to any pending or threatened suit, action or legal, administrative, arbitration or other proceeding which might materially and adversely affect the transactions contemplated by this Amendment Agreement, nor does Amgen know of any
facts which are likely with the passage of time to give rise to such a suit, action or proceeding. 
 (d) No notices, reports
or filings are required to be made by Amgen with, nor are any consents, registrations, approvals, permits or authorizations required to be obtained by Amgen from a Governmental Entity, in connection with the execution, delivery and performance of
this Amendment Agreement by any of the parties hereto. 
  

	4.	GUARANTEE 

 Notwithstanding the
provisions of any other document, agreement or instrument (including but not limited to the Corporate Split Agreement between Kirin Holdings and Kirin Pharma), the provisions of the Shareholders’ Agreement, as amended by this Amendment
Agreement, shall remain binding upon Kirin Holdings and Kirin Holdings shall not be released or discharged from any obligations in respect thereof. Notwithstanding the provisions of any other document, agreement or instrument, Kirin Holdings hereby
absolutely, unconditionally and irrevocably guarantees to Amgen, as a primary obligor and not merely as a surety, the due and punctual performance and observance of, and compliance with, all covenants, agreements, obligations, liabilities,
representations and warranties of Kirin Pharma under or pursuant to the Shareholders’ Agreement, each Kirin/Amgen Agreement and this Amendment Agreement, as each such agreement may be amended or modified from time to time with or without notice
to Kirin Holdings (all such obligations being collectively referred to as the “Guaranteed Obligations”). Amgen shall provide reasonable written notice to Kirin Holdings if Kirin Pharma fails to perform the Guaranteed Obligations
when due. Kirin Holdings irrevocably and unconditionally waives, and agrees that its liability under this representation shall be unaffected by, any act, omission, delay or other circumstance or election of remedies by Amgen that might 

  

 18 








 
otherwise constitute a legal or equitable discharge or defense of a guarantor or surety. Kirin Holdings further agrees that its guarantee is a continuing
guarantee of payment and performance of the Guaranteed Obligations when due (whether or not any bankruptcy, insolvency or similar proceeding under applicable law shall have stayed the accrual or collection of any of the Guaranteed Obligations or
operated as a discharge thereof) and not of collection. The foregoing guarantee shall [*] (a) as of the consummation of any transaction providing for a Purchase Event, if and only if Kirin Holdings [*] such transaction or (b) after the [*]
that Kirin-Amgen [*] the agreements between Kirin-Amgen, on the one hand, and Kirin Holdings and/or Kirin Pharma, on the other hand, including all of such Kirin/Amgen Agreements, in accordance with Section 17.03 of the Shareholders Agreement,
except that, in any such case of (a) or (b), no such [*] shall [*] Kirin Holdings from [*] with respect to any Guaranteed Obligations that [*] to such [*]. 
  

	5.	MISCELLANEOUS 

 5.01 No Further Amendment

 Except as expressly set forth in this Amendment Agreement, from and after the effective time of the Reorganization, all the
terms and conditions of the Shareholders’ Agreement and each Kirin/Amgen Agreement shall remain unchanged and in full force and effect and shall continue to be binding between or among Kirin Pharma, Kirin Holdings and either or both of Amgen
and Kirin-Amgen, as the case may be. 
 5.02 Entire Agreement; Amendment 
 This Amendment Agreement (together with its Appendices and all documents and instruments delivered in connection herewith) constitutes the
full and complete agreement and understanding between the parties hereto and shall supersede any and all prior written and oral agreements concerning the subject matter contained herein. This Amendment Agreement may not be modified or amended, nor
may any provision hereof be waived without a written instrument executed by the parties hereto. 
 5.03 Waiver 
 No failure or delay by any Party to insist upon the strict performance of any term, condition, covenant or agreement of this Amendment
Agreement, or to exercise any right, power or remedy hereunder or thereunder or consequent upon a breach hereof or thereof shall constitute a waiver of any such term, condition, covenant, agreement, right, power or remedy or of any such breach or
preclude such Party from exercising any such right, power or remedy at any later time or times. 
 5.04 Remedies 
 No right, power or remedy herein conferred upon or reserved to any Party is intended to be exclusive of any other right, power or remedy
or remedies, and each and every right, power and remedy of any Party pursuant to this Amendment Agreement or now or hereafter existing at law or in equity or by statute or otherwise shall to the extent permitted by law be cumulative and concurrent,
and shall be in addition to every other right, power or remedy pursuant to this Amendment Agreement, or now or hereafter existing at law or in equity or by 

  

 19 








 
statute or otherwise and the exercise or beginning of the exercise by any Party of any one or more of such rights, powers or remedies shall not preclude the
simultaneous or later exercise by any Party of any or all such other rights, powers or remedies. 
 5.05 Headings 
 Headings in this Amendment Agreement are included herein for the convenience of reference only and shall not constitute a part of this
Amendment Agreement for any purpose. 
 5.06 Effectiveness 
 Any provision of this Amendment Agreement which is prohibited or unenforceable in any jurisdiction shall as to such jurisdiction be
ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof or effecting the validity or enforceability of such provision in any other jurisdiction. 
 5.07 Governing Law 
 This Amendment Agreement, other than the provision contained in the first paragraph of Section 1.03, shall be construed in accordance with the internal laws, and not the law of conflicts, of the State of California applicable to
agreements made and to be performed in such state. 
 5.08 Binding Effect 
 This Amendment Agreement shall be binding upon and inure to the benefit of the parties hereto, their successors and assigns. 

5.09 Number and Gender 
 Words in the singular shall include the plural, and words in a particular gender shall include either or both additional genders, when the context in which such words are used indicates that such is the intent. 
 5.10 Counterparts 
 This Amendment Agreement may be executed in one or more counterparts by the parties hereto. All counterparts shall be construed together and shall constitute one agreement. 
 5.11 Validity 
 If for
any reason any clause or provision of this Amendment Agreement, or the application of any such clause or provision in a particular context or to a particular situation, circumstance or person, should be held unenforceable, invalid or in violation of
law by any court or other tribunal, then the application of such clause or provision in contexts or to situations, circumstances or persons other than that in or to which it is held unenforceable, invalid or in violation of law shall not be affected
thereby, and the remaining clauses and provisions hereof shall nevertheless remain in full force and effect. 
  

 20 








 5.12 Confidentiality 
 (a) Each Party agrees not to, and agrees to cause such Party’s directors, officers, employees, etc. not to, disclose or permit the
disclosure to any third party of any confidential, non-public or proprietary information relating to this Amendment Agreement (collectively, “Amendment Confidential Information”); provided that such disclosure may be made
(i) with the prior written consent of Kirin Holdings and Amgen, (ii) to any Person who is a director, officer, employee, attorney, consultant or accountant of a Party who needs to know such information for the purposes of this Amendment
Agreement, and agrees to be bound by such Party’s obligation hereunder, (iii) subject to Paragraph 5.12(b), pursuant to a subpoena or order issued by a court, arbitrator or governmental body, agency or official, (iv) subject to
Paragraph 5.12(c), to the extent required by applicable law or by the rules of any securities exchange or (v) to any Person, who agrees in writing, for the benefit of the nondisclosing Parties, to comply with this Section 5.12, in
connection with a due diligence investigation undertaken by such Person in connection with a merger, consolidation or Share Exchange with the disclosing Party, or a purchase of a material portion of the assets or the business (including corporate
split) of the disclosing Party. 
 (b) In the event that a Party or any of its Affiliates is required to disclose any
Amendment Confidential Information in connection with any judicial or administrative proceedings (by oral questions, interrogatories, requests for information or documents, subpoena, civil investigation demand or similar process), that Party in
advance of such disclosure shall provide the other Parties with prompt notice of such requirement(s). Such Party also agrees, to the extent legally permissible, to provide the other Parties, in advance of any such disclosure, with a list of any
Amendment Confidential Information it intends to disclose (and, if applicable, the text of the disclosure language itself) and to cooperate with the other Parties to the extent they may seek to limit such disclosure, including, if requested, taking
all reasonable steps to resist or avoid any such judicial or administrative proceeding referred to above. If, in the absence of a protective order or the receipt of a waiver from the other Parties after a request in writing therefor is made by such
Party (such request to be made as soon as practicable to allow the other Parties a reasonable amount of time to respond thereto), such Party or any of its Affiliates is legally required to disclose the Amendment Confidential Information to any
tribunal to avoid censure or penalty, such Party may disclose such information without liability hereunder. 
 (c) No Party
shall issue or publish any press release or other public communication concerning this Amendment Agreement without the express written consent of the other Parties, except to the extent such public communication is required by applicable law or by
the rules of any securities exchange; provided that, to the extent practicable, such Party shall provide notice to and consult with the other Parties on the content of such communication. Kirin Holdings, Kirin Pharma and Kirin-Amgen hereby
acknowledge and agree that Amgen shall have the right to file an unredacted copy of this Amendment Agreement with the U.S. Securities and Exchange Commission. 
  

 21 








 IN WITNESS WHEREOF, the undersigned have caused this Amendment Agreement to be executed by their duly
authorized representatives in the manner legally binding upon them. 
  

					
	KIRIN BREWERY COMPANY, LIMITED
		
	By	 	/s/ Kazuyasu Kato
		 	Name:	 	Kazuyasu Kato
		 	Title:	 	President, Representative Director
		 	Date:	 	June 28, 2007
	
	KIRIN PHARMA COMPANY, LIMITED
		
	By	 	/s/ Katsuhiko Asano
		 	Name:	 	Katsuhiko Asano, Ph.D
		 	Title:	 	President, Representative Director
		 	Date:	 	June 28, 2007
	
	AMGEN INC.,
	a Delaware corporation
		
	By	 	/s/ George J. Morrow
		 	Name:	 	George J. Morrow
		 	Title:	 	Executive Vice President, Global
		 	Commercial Operations
		 	Date:	 	June 28, 2007
	
	KIRIN-AMGEN, INC.,
	a Delaware corporation
		
	By	 	/s/ Dominique Monnet
		 	Name:	 	Dominique Monnet
		 	Title:	 	President
		 	Date:	 	June 28, 2007









 Appendix A 
 Kirin/Amgen Agreements 
 [*] 
  


 A-1 








 Appendix B 
 Restated Charter 







 Appendix C 
 Asian Countries 
 [*] 
  

 C-1 








 Appendix D 
 Reorganization Package 
 [*] 
  


 D-1