# SolviNix ® 

# LC

MASTER LABEL

Sub

- label A: 1.2 Fluid Ounces (35 m l ) Vial

Sub

- label B: 0.34 Fluid Ounce (10 m l ) Vial

# SolviNix ® 

# LC

Sub

- label A: 1.2 Fluid Ounces (35 m l ) VialSOLVINIX ® LC 35-ml vial 1 EPA Reg. No.: 81179-G
EPA Establishment No.: 081179-FL-001
Batch Code:
Use Before:
NOT FOR SALE OR USE AFTER THE
DATE STAMPED ABOVE 

# S OLVI 

# N IX ® 

# LC

A Biological Herbicide for Control of Tropical Soda Apple ( Solanum viarum ) For post-emergence application to kill tropical soda apple

Active Ingredient: Tobacco mild green mosaic tobamovirus U2 (TMGMV U2)...............2.9% w/v* Other ingredients .............97.1% w/v
Total ........................ 100.0% w/v
*Contains: A minimum of 0.03 ounce of the active ingredient, TMGMV U2, per fluid ounce of
SolviNix ® LC (29 milligrams of TMGMV U2 per ml
of SolviNix ® LC), with an es timated minimum of
1.25 x 10 16 TMGMV U2 virions per fluid ounce of
SolviNix ® LC (4.23 X 10 14 TMGMV U2 virions per gram of SolviNix ® LC).



### Net Contents : 1.2 fluid ounces (35 ml)

For use only in pastures and wooded areas that are fenced to contain grazing animals

PRECAUTIONARY STATEMENTS

HAZARDS TO HUMANS AND DOMESTIC
ANIMALS

CAUTION Harmful if swallowed, absorbed through the skin, or inhaled. Causes moderate eye irritation. Avoid breathing spray mist. Avoid contact with skin, eyes, or clothing. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacc o. Remove and wash contaminated clothing before reuse. 

### FIRST AID

If swallowed:

 Call poison control center in your area or a

doctor immediately for treatment advice.

 Have person sip a glass of water if able to

swallow.

 Do not induce vomiting unless told to by the

poison control center or the doctor.

 Do not give anything to an unconscious person.

If on skin or clothing:

 Take off contaminated clothing.

 Rinse skin immediately with plenty of water for

15-20 minutes

 Call poison control center or a doctor for

treatment advice.

If inhaled:

 Move person to fresh air.

 If person is not breathing, call 911 or an

ambulance, and then give artificial respiration, preferably mouth-to-m outh if possible.

 Call a poison control center or doctor for further

treatment advice.

If in eyes:

 Hold eye open and rinse slowly and gently with

water for 15-20 minutes.

 Remove contact lenses, if present, after the first

5 minutes, and then continue rinsing the eye.

 Call poison control center or a doctor for

treatment advice.

Important:

 Have the product container or label with you

when calling doctor, or going for treatment. KEEP OUT OF REACH OF CHILDRENSOLVINIX ® LC 35-ml vial 2 ENVIRONMENTAL HAZARDS

S

OLVI N IX ® LC is intended for terrestrial uses only. Do not apply it directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when disposing equipment wash water.

The virus in S OLVI N IX ® LC has no natural means of spread other than by physical and abrasive contact between infected and healthy plants. A remote possibility is through workers (via contaminated clothes, shoes, hands) and contaminated application equipment. To prevent unwanted virus spread, avoid
contact with skin and clot hing. Wash skin with soap and water and clothes with laundry detergent. See below instructions for washing application equipment. Thorough washing will prevent spread.

STOP any pruning or mechanical activities in treated areas, such as mowing or tillage, 48 hours before, and after, application of S OLVI N IX ® LC

.

MAY INFECT SOME NON-WOODY
FLOWERING PLAN TS, INCLUDING SOLANACEOUS CROP PLANTS (EGGPLANT, PEPPER, TOBACCO, AND TOMATILLO). DIRECTIONS FOR USE It is a violation of Federal law to use this product in a manner inconsistent with its labeling.

For use only in pastures and wooded areas that are fenced to contain grazing animals; with a backpack sprayer or a hand-held applicator, the

latter dedicated for S OLVI N IX ® LC application only.

For any surviving treated Tropical Soda Apple ( Solanum viarum ) plants, re-apply according to label instructions. If there are still surviving plants,
consider other mechanical or chemical means of
control. Consult local extension recommendations and contact the registrant.

PRODUCT INFORMATION

S

OLVI N IX ® LC is a post-emergence bioherbicide for tropical soda apple (TSA). It contains a plant virus, Tobacco mild green mosaic tobamovirus Strain U2 (TMGMV), as the active ingredient.

TMGMV kills TSA by triggering a systemic lethal hypersensitive plant response. To initiate this herbicidal action, the virus must enter the plant cells through minute injuries to the plant cell walls. The virus can then replicate and move from cell-to-cell, eliciting the hypersensitive response. To assure virus

entry, S OLVI N IX ® LC is applied to TSA foliage with a high-pressure (80 psi), narrow-stream sprayer or a hand-held herbicide applicator as described
below under APPLICATI ON INSTRUCTIONS.

S

OLVI N IX ® LC is sold and shipped in a frozen state. It should be kept frozen in a freezer until ready to be thawed and used. See Storage and Disposal
section for further details.

When properly applied us ing the specified method,

SOLVINIX ® LC will cause treated TSA plants to

wilt in about 2-4 weeks af ter application followed by plant death. Brown leaf spots or flecks may appear on leaves directly exposed to the virus (i.e., inoculated leaves) in 3-5 days after inoculation and before the plant starts to wilt. The plants will die in a few days following initial wilting and the entire plant, including roots will be killed. Rarely, dying plants may sucker but the new growth will also be killed. USE RESTRICTIONS

APPLY ONLY WHEN TROPICAL SODA APPLE
PLANTS ARE ACTIVELY GROWING.

DO NOT APPLY WITHIN 300 FEET OF
GREENHOUSE AND GRAFTING OPERATIONS.

SPRAY DIRECTLY AT THE TARGET PLANT
- AVOID ANY CROPS AND NONTARGET
PLANTS.

MUST NOT RE-USE THE SPRAY EQUIPMENT
FOR OTHER USES WITHOUT THOROUGH
CLEANING AS SPECIFIED.

DO NOT APPLY THIS PRODUCT THROUGH
ANY TYPE OF IRRIGATION SYSTEM.SOLVINIX ® LC 35-ml vial 3 Older plants may die more slowly than younger plants.

In order for S OLVI N IX ® LC to be effective, the TSA plant must be healthy and vigorously growing
when inoculated. Therefore, S OLVI N IX ® LC should be applied only to actively growing TSA plants. Considering this, S OLVI N IX ® LC will be sold seasonally to coincide with the annual growth cycle of TSA, from spring to early fall.

THE FOLLOWING PLANTS WERE SHOWN
TO BE DAMAGED SLI GHTLY OR SEVERELY

IF DIRECTLY EXPOSED TO S OLVI N IX ® LC : TMGMV is adapted to plants in the Solanaceae family. Of the 435 plant species screened by manual inoculation with TMGMV, the following plants developed infection symptoms: Common globe amaranth ( Gomphrena globosa; family Amaranthaceae); rattlesnakemaster, eryngo, and plains eryngo ( Eryngium aquaticum, E. dorae, and E. planum; Apiaceae); crape jasmine ( Tabernaemontana divaricata; Apocynaceae); African daisy ( Osteospermum sp. cv. Sheila; Asteraceae); balsams ( Impatiens sp. cvs. Timor and Toyota; Balsaminaceae); salvation jane ( Echium plantagineum; Boraginaceae ); quinoa ( Chenopodium quinoa ; Chenopodiaceae); boatlily and inchplant ( Tradescantia [=Rhoeo] spathacea and T. zebrina; Commelinaceae); Florida pusley ( Richardia scabra;
Rubiaceae ); plants belonging to the Gesneriaceae such as African violet ( Saintpaulia spp.) and gloxinia ( Sinningia spp.); wishbone flower ( Torenia fournieri; Scrophulariaceae) , and the following species in the
Solanaceae: Jamaican forget-me-not ( Browallia americana), trailing petunias ( Calibrachoa spp

. and Calibrachoa × hybrida ), some cultivars of bell pepper ( Capsicum annuum), some cultivars of scotch bonnet, ‘Aji dulce’, and Indian chili ( C. chinense), jasmine tobacco ( Nicotiana alata), Benthamiana
tobacco (N. benthamiana), Cleveland’s tobacco ( N. clevelandii), Debney's tobacco ( N. debneyi ), tree tobacco ( N. glauca ), glutinosa tobacco ( N. glutinosa ), Australian tobacco ( Nicotiana hesperis ), Native tobacco ( Nicotiana occidentalis ), some cultivars of commercial tobacco ( N. tabacum), woodland tobacco ( N. sylvestris ), and two experimental hybrids: Edwardson’s tobacco ( Nicotiana x edwardsonii) and Sander’s tobacco ( Nicotiana x sanderae), petunias ( Petunia sp., Petunia sp. cv. Surfinia, Petunia x hybrida), violet-flower petunia ( P. integrifolia), Chinese lantern ( Physalis alkekengi), Downy groundcherry ( Physalis floridana ), cutleaf groundcherry (P. angulata), Mexican groundcherry ( P. philadelphica), Walter’s groundcherry ( P. walteri), needleleaf solanum ( Solanum acerifolium), soda-apple nightshade ( S. aculeatissimum), Ethiopian nightshade ( S. aethiopicum), American black nightshade ( S. americanum), Bahama nightshade (S. bahamense), cockroach berry (S. capsicoides), mamoncillo (S. caripense), twoleaf nightshade (S. diphyllum), Jamaican nightshade (S. jamaicense), earleaf nightshade (S. mauritianum), black nightshade (S. nigrum), hoe nightshade (S. physalifolium), husk

tomato (Physalis pubescens), West Indian nightshade (S. ptycanthum), buffalobur nightshade (S. rostratum), hairy nightshade (S. sarrachoides), sticky nightshade (S. sisymbriifolium), spiny solanum (S. spinosissimum), fragrant solanum (S. suaveolens),
and hairy nightshade (S. villosum ).

APPLICATION RATE

S

OLVI N IX ® LC is packaged in 1.2 ounces (35 ml) quantity in a 50 ml plastic screw-cap vial. Apply

S

OLVI N IX ® LC at the rate of 1.5 ml per gallon of water (~10 micrograms of active ingredient per ml). Each 50 ml vial containing 35 ml S OLVI N IX ® LC should be sufficient to treat approximately 2500 TSA plants with a backpack spra yer set at 80 psi and at a volume of 20 to 40 ml (approximately 0.7 to 1.5 ounces) per plant.

The amount of S OLVI N IX ® LC needed to treat an area and application volume will depend on the density of TSA infestation, distribution pattern, application method, applicator efficiency, height of grass stand, terrain, and other likely factors.

APPLICATION INSTRUCTIONS Use the following methods to apply S OLVI N IX ®

LC : 1) With a high-pressure backpack sprayer delivering a narrow jet of spray at 80 psi at the point of impact on TSA leaves. Ideally, the distance from
the nozzle to the leaves should be about 12 to 18 inches. Application with a conventional backpack sprayer having a 3-foot wand and a Quick TeeJet Cap containing a D-1 or D-2 orifice plate and a rubber O-ring gasket yields good foliage penetration. 2) With a hand-held herbicide applicator for scattered TSA infestations. Hand-held applicators includeSOLVINIX ® LC 35-ml vial 4 commercially available herbicide wipers that typically deliver herbicide through a wick or a tassle of wicks attached to a plastic re-fillable tube. Consult the registrant for the appropriate application method for your situation.

Use a backpack sprayer or a hand-held applicator, the

latter dedicated for S OLVI N IX ® LC application.

About an hour before application, remove the required number of frozen S OLVI N IX ® LC vials

from the freezer and allow the contents to thaw at room temperature. The vials may be thawed by
immersion in water at ROOM temperature. The
vials MUST NOT BE THAW ED by immersion in hot water or by direct heating as high temperature will destroy or inactivate S OLVI N IX ® LC . Add the
fully melted S OLVI N IX ® LC to the spray tank filled with about half of the final volume of water required for the spray. Triple rinse the vial with water and add the rinsate to the spray mix. Add water to bring the spray mix to the desired spray volume. Use clean potable water to mix with and apply S OLVI N IX ®

LC

.

Alternatively, use only the required quantity from the vial by transferring at the rate of 1.5 ml of

S

OLVI N IX ® LC per gallon of water (see Table below). Use the plastic liquid dispenser (Transfer Pipet) enclosed in the S OLVI N IX ® LC package to transfer when only a fraction of the vial’s content is required. Promptly re-freeze and store the unused

S

OLVI N IX ® LC in the original vial, and the dispenser, for further use within the product’s expiration date. Do not melt and re-freeze the product
more than three times. IF THE 1.2 OZ (35 ML) SOLVINIX ® LC VIAL

IS TOO LARGE FOR YO UR NEEDS, BUY AND USE THE 0.34 OZ (10 ML) VIAL.

Apply S OLVI N IX ® LC to actively growing TSA plants at pre-flowering stage to prevent fruit-set and production of a new crop of seeds. For best results, apply in late spring or early summer in Florida and the Southeast. A single, properly directed application to a few young and healthy leaves per plant is
sufficient to allow the virus to infect and kill the entire plant.

Repeat applications will be necessary to treat plants that are missed in the first application or subsequently emerged plants. If there are still surviving plants after treatment, consider other
mechanical or chemical means of control. Consult
local extension recommendations and contact the registrant.

Do not apply S OLVI N IX ® LC if leaves are wet from rain or morning dew. Allow the leaves to dry before application.

S

OLVI N IX ® LC can be applied in late summer or early fall to control late-emerging plants or plants that were missed in earlier applications. The plants must be actively growing when S OLVI N IX ® LC is applied; dormant or senescent plants may not respond normally to the virus and may not die.

For application with a high-pressure sprayer or a hand-held applicator, mix S OLVI N IX ® LC at the rate of 1.5 ml of per one gallon of water in a clean, pre-washed spray tank, a clean plastic bucket, or a clean one-gallon water jug*. Mix thoroughly before application. If using a hand-held applicator, carefully transfer and fill the app licator with the diluted

S

OLVI N IX ® LC from the bucket or the jug.

*YOU MUST NOT USE A WASHED MILK JUG
BECAUSE ANY MILK RESIDUE PRESENT MAY
INACTIVATE THE VIRUS. Quantity of S OLVI N IX ® LC to Add To Amount of Water

1.5 Milliliters 1 Gallon

10 Milliliters - the entire content
of a 0.34-ounce vial 6.5 Gallons

35 Milliliters - the entire content
of a 1.2-ounce vial 23 GallonsSOLVINIX ® LC 35-ml vial 5 STORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal.

Pesticide Storage: Store S OLVI N IX ® LC in a freezer until it is ready to be used. Do not store

S

OLVI N IX ® LC where food or medicine for human consumption is stored.

Pesticide Disposal: To avoid waste, use all material in this container by application according to label directions. If wastes cannot be avoided, offer remaining product to a waste disposal facility or pesticide disposal program (often such programs ar e run by state or local governments or by industr y). DO NOT discharge

unused S OLVI N IX ® LC onto the ground, into water, or onto nontarget plants.

Container Handling: Non-refillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or
a mix tank. Fill the container 1⁄4 full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke. After mixing, do not allow SOLVINIX ® LC to remain in the application tank for more than 24 hours or allow it to reach temperatures above 113°F (45°C). Avoid prolonged exposure of SOLVINIX ®

LC to direct sunlight or heat.

The sprayer, namely the tank and the spray wand
combined, used for S OLVI N IX ® LC application

MUST BE CLEANED THOROUGHLY AND
IMMEDIATELY AFTER US E by: 1) flushing it twice by running clean water through and discharging the liquid on a Tropical Soda Appleplant; 2) then flushing it once with dilute dishwashing soap (2 tablespoons per gallon of water); and 3) finally flushing it twice with water.

REMARKS

S

OLVI N IX ® LC must be used only against TSA since it is not effective against other weeds. Do not apply S OLVI N IX ® LC to TSA plants that are drought-stressed or dormant (i.e., not actively growing) or occur in waterlogged sites. Do not apply in late fall when nighttime temperatures begin to fall below 55°F (13°C) and if early frost is likely.

S

OLVI N IX ® LC is effective only when applied post-emergence; it has no pre-emergence or soil residual activity against TSA. It will not be effective if applied via soil or irrigation water or any other method not specified in this label.

S

OLVI N IX ® LC does not require the use of any additives or adjuvants. Do not mix it with any other
material not mentioned in this label.

***For any surviving treated Tropical Soda Apple ( Solanum viarum ) plants, re-apply according to label instructions. If there are still surviving plants,
consider other mechanical or chemical means of
control. Consult local extension recommendations and contact the registrant. The registrant will notify EPA under FIFRA 6(a)(2) for assessment of pesticide resistance in Tropical Soda Apple. WARRANTY AND DISCLAIMER OF
WARRANTIES BioProdex, Inc. warrants that S OLVI N IX ® LC conforms to the description and conditions on this label and that it will perform as indicated when used
under the directions and conditions of the label. BioProdex, Inc. and/or the seller makes no other expressed or implied warranty of fitness, merchantability, or otherwise. S OLVI N IX ® LC should provide satisfactory activity up to 12 months after purchase provided the product is stored at -4°F (-20°C).SOLVINIX ® LC 35-ml vial 6 LIMITATIONS OF LIABILITY It is the manufacturer’s intent that the liability of BioProdex, Inc. or of the seller for damages arising from the use of this product is limited to the replacement cost of the product used and shall not include any application costs or consequential damages such as loss of profits or other values.

NO CHANGES AUTHORIZED No one other than an authorized agent of BioProdex,
Inc. is allowed to make any other warranty or change the conditions, disclaimers, or limitations stated herein. Any authorization to make changes should be in writing and in specific reference to this label.

RIGHTS AND PRIVILEGES

** Use of TMGMV to control tropical soda apple by eliciting a lethal hypersensitive host response is protected under the Patents US 6,689,718 B2 and US 7,494,955 B2. These patents are licensed to

B

i o P r

o d e

x

, I n c

.

B

i o P r

o d e

x

, I n c., 3131 NW 13 th Street, # 54, Gainesville, FL 32609-2183, USA TEL: 352-278-1572; FAX: 352-872-5035
Email: info@bioprodex.com ; Website: www.bioprodex.com

.

# SolviNix ® 

# LC

Sub

- label B: 0.34 Fluid Ounce (10 m l ) VialSOLVINIX ® LC 10-ml vial 1 EPA Reg. No.: 81179-G
EPA Establishment No.: 081179-FL-001
Batch Code:
Use Before:
NOT FOR SALE OR USE AFTER THE
DATE STAMPED ABOVE 

# S OLVI 

# N I X ® 

# LC

A Biological Herbicide for Control of Tropical Soda Apple ( Solanum viarum ) For post-emergence application to kill tropical soda apple

Active Ingredient:

Tobacco mild green mosaic tobamovirus U2 (TMGMV U2).....................2.9% w/v* Other ingredients ................97.1% w/v
Total ........................... 100.0% w/v
*Contains: A minimum of 0.03 ounce of the active ingredient, TMGMV U2, per fluid ounce of
SolviNix ® LC (29 milligrams of TMGMV U2 per ml
of SolviNix ® LC), with an es timated minimum of
1.25 x 10 16 TMGMV U2 virions per fluid ounce of
SolviNix ® LC (4.23 X 10 14 TMGMV U2 virions per gram of SolviNix ® LC).



### Net Contents : 0.34 fluid ounce (10 ml)

For use only in pastures and wooded areas that are fenced to contain grazing animals

PRECAUTIONARY STATEMENTS

HAZARDS TO HUMANS AND DOMESTIC
ANIMALS

CAUTION Harmful if swallowed, absorbed through the skin, or inhaled. Causes moderate eye irritation. Avoid breathing spray mist. Avoid contact with skin, eyes, or clothing. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacc o. Remove and wash contaminated clothing before reuse. 

### FIRST AID

If swallowed:

 Call poison control center in your area or a

doctor immediately for treatment advice.

 Have person sip a glass of water if able to

swallow.

 Do not induce vomiting unless told to by the

poison control center or the doctor.

 Do not give anything to an unconscious person.

If on skin or clothing:

 Take off contaminated clothing.

 Rinse skin immediately with plenty of water for

15-20 minutes

 Call poison control center or a doctor for

treatment advice.

If inhaled:

 Move person to fresh air.

 If person is not breathing, call 911 or an

ambulance, and then give artificial respiration, preferably mouth-to-m outh if possible.

 Call a poison control center or doctor for further

treatment advice.

If in eyes:

 Hold eye open and rinse slowly and gently with

water for 15-20 minutes.

 Remove contact lenses, if present, after the first

5 minutes, and then continue rinsing the eye.

 Call poison control center or a doctor for

treatment advice.

Important:

 Have the product container or label with you

when calling doctor, or going for treatment. KEEP OUT OF REACH OF CHILDRENSOLVINIX ® LC 10-ml vial 2 ENVIRONMENTAL HAZARDS

S

OLVI N IX ® LC is intended for terrestrial uses only. Do not apply it directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when disposing equipment wash water.

The virus in S OLVI N IX ® LC has no natural means of spread other than by physical and abrasive contact between infected and healthy plants. A remote possibility is through workers (via contaminated clothes, shoes, hands) and contaminated application equipment. To prevent unwanted virus spread, avoid
contact with skin and clot hing. Wash skin with soap and water and clothes with laundry detergent. See below instructions for washing application equipment. Thorough washing will prevent spread.

STOP any pruning or mechanical activities in treated areas, such as mowing or tillage, 48 hours before, and after, application of S OLVI N IX ® LC

.

MAY INFECT SOME NON-WOODY
FLOWERING PLAN TS, INCLUDING SOLANACEOUS CROP PLANTS (EGGPLANT, PEPPER, TOBACCO, AND TOMATILLO). DIRECTIONS FOR USE It is a violation of Federal law to use this product in a manner inconsistent with its labeling.

For use only in pastures and wooded areas that are fenced to contain grazing animals; with a backpack sprayer or a hand-held applicator, the

latter dedicated for S OLVI N IX ® LC application only.

For any surviving treated Tropical Soda Apple ( Solanum viarum ) plants, re-apply according to label instructions. If there are still surviving plants,
consider other mechanical or chemical means of
control. Consult local extension recommendations and contact the registrant.

. PRODUCT INFORMATION

S

OLVI N IX ® LC is a post-emergence bioherbicide for tropical soda apple (TSA ). It contains a plant virus, Tobacco mild green mosaic tobamovirus Strain U2 (TMGMV), as the active ingredient.

TMGMV kills TSA by triggering a systemic lethal hypersensitive plant response. To initiate this herbicidal action, the virus must enter the plant cells through minute injuries to the plant cell walls. The virus can then replicate a nd move from cell-to-cell, eliciting the hypersensitive response. To assure virus

entry, S OLVI N IX ® LC is applied to TSA foliage with a high-pressure (80 psi), narrow-stream sprayer or a hand-held herbicide applicator as described
below under APPLICATI ON INSTRUCTIONS.

S

OLVI N IX ® LC is sold and shipped in a frozen state. It should be kept frozen in a freezer until ready to be thawed and used. See Storage and Disposal
section for further details.

When properly applied using the specified method,

S

OLVI N IX ® LC will cause treated TSA plants to

wilt in about 2-4 weeks afte r application followed by plant death. Brown leaf spot s or flecks may appear on leaves directly exposed to the virus (i.e., inoculated leaves) in 3-5 days after inoculation and before the plant starts to w ilt. The plants will die in a few days following initial wilting and the entire plant, including roots w ill be killed. Rarely, dying plants may sucker but the new growth will also be USE RESTRICTIONS

APPLY ONLY WHEN TROPICAL SODA APPLE
PLANTS ARE ACTIVELY GROWING.

DO NOT APPLY WITHIN 300 FEET OF
GREENHOUSE AND GRAFTING OPERATIONS.

SPRAY DIRECTLY AT THE TARGET PLANT
- AVOID ANY CROPS AND NONTARGET
PLANTS.

MUST NOT RE-USE THE SPRAY EQUIPMENT
FOR OTHER USES WITHOUT THOROUGH
CLEANING AS SPECIFIED.

DO NOT APPLY THIS PRODUCT THROUGH
ANY TYPE OF IRRIGATION SYSTEM.SOLVINIX ® LC 10-ml vial 3 killed. Older plants may die more slowly than younger plants.

In order for S OLVI N IX ® LC to be effective, the TSA plant must be healthy and vigorously growing
when inoculated. Therefore, S OLVI N IX ® LC should be applied only to actively growing TSA plants. Considering this, S OLVI N IX ® LC will be sold seasonally to coincide with the annual growth cycle of TSA, from spring to early fall.

THE FOLLOWING PLANTS WERE SHOWN
TO BE DAMAGED SLI GHTLY OR SEVERELY

IF DIRECTLY EXPOSED TO S OLVI N IX ® LC : TMGMV is adapted to plants in the Solanaceae family. Of the 435 plant species screened by manual inoculation with TMGMV, the following plants developed infection symptoms: Common globe amaranth ( Gomphrena globosa; family Amaranthaceae); rattlesnakemaster, eryngo, and plains eryngo ( Eryngium aquaticum, E. dorae, and E. planum; Apiaceae); crape jasmine ( Tabernaemontana divaricata; Apocynaceae); African daisy ( Osteospermum sp. cv. Sheila; Asteraceae); balsams ( Impatiens sp. cvs. Timor and Toyota; Balsaminaceae); salvation jane ( Echium plantagineum; Boraginaceae ); quinoa ( Chenopodium quinoa ; Chenopodiaceae); boatlily and inchplant ( Tradescantia [=Rhoeo] spathacea and T. zebrina; Commelinaceae); Florida pusley ( Richardia scabra;
Rubiaceae ); plants belonging to the Gesneriaceae such as African violet ( Saintpaulia spp.) and gloxinia ( Sinningia spp.); wishbone flower ( Torenia fournieri; Scrophulariaceae) , and the following species in the
Solanaceae: Jamaican forget-me-not ( Browallia americana), trailing petunias ( Calibrachoa spp

. and Calibrachoa × hybrida ), some cultivars of bell pepper ( Capsicum annuum), some cultivars of scotch bonnet, ‘Aji dulce’, and Indian chili ( C. chinense), jasmine tobacco ( Nicotiana alata), Benthamiana
tobacco (N. benthamiana), Cleveland’s tobacco ( N. clevelandii), Debney's tobacco ( N. debneyi ), tree tobacco ( N. glauca ), glutinosa tobacco ( N. glutinosa ), Australian tobacco ( Nicotiana hesperis ), Native tobacco ( Nicotiana occidentalis ), some cultivars of commercial tobacco ( N. tabacum), woodland tobacco ( N. sylvestris ), and two experimental hybrids: Edwardson’s tobacco ( Nicotiana x edwardsonii) and Sander’s tobacco ( Nicotiana x sanderae), petunias ( Petunia sp., Petunia sp. cv. Surfinia, Petunia x hybrida), violet-flower petunia ( P. integrifolia), Chinese lantern ( Physalis alkekengi), Downy groundcherry ( Physalis floridana ), cutleaf groundcherry (P. angulata), Mexican groundcherry ( P. philadelphica), Walter’s groundcherry ( P. walteri), needleleaf solanum ( Solanum acerifolium), soda-apple nightshade ( S. aculeatissimum), Ethiopian nightshade ( S. aethiopicum), American black nightshade ( S. americanum), Bahama nightshade (S. bahamense), cockroach berry (S. capsicoides), mamoncillo (S. caripense), twoleaf nightshade (S. diphyllum), Jamaican nightshade (S. jamaicense), earleaf nightshade (S. mauritianum), black nightshade (S. nigrum), hoe nightshade (S. physalifolium), husk

tomato (Physalis pubescens), West Indian nightshade (S. ptycanthum), buffalobur nightshade (S. rostratum), hairy nightshade (S. sarrachoides), sticky nightshade (S. sisymbriifolium), spiny solanum (S. spinosissimum), fragrant solanum (S. suaveolens),
and hairy nightshade (S. villosum ).

APPLICATION RATE

S

OLVI N IX ® LC is packaged in 0.34 ounce (10 ml) quantity in a 15 ml plastic screw-cap vial. Apply

S

OLVI N IX ® LC at the rate of 1.5 ml per gallon of water (~10 micrograms of active ingredient per ml). Each 15 ml vial containing 10 ml S OLVI N IX ® LC should be sufficient to treat approximately 600 TSA plants with a backpack spra yer set at 80 psi and at a volume of 20 to 40 ml (approximately 0.7 to 1.5 ounces) per plant.

The amount of S OLVI N IX ® LC needed to treat an area and application volume will depend on the density of TSA infestation, distribution pattern, application method, applicator efficiency, height of grass stand, terrain, and other likely factors.

APPLICATION INSTRUCTIONS Use the following methods to apply S OLVI N IX ®

LC : 1) With a high-pressure backpack sprayer delivering a narrow jet of spray at 80 psi at the point of impact on TSA leaves. Ideally, the distance from
the nozzle to the leaves should be about 12 to 18 inches. Application with a conventional backpack sprayer having a 3-foot wand and a Quick TeeJet Cap containing a D-1 or D-2 orifice plate and a rubber O-ring gasket yields good foliage penetration. 2) With a hand-held herbicide applicator for scatteredSOLVINIX ® LC 10-ml vial 4 TSA infestations. Hand-held applicators include commercially available herbicide wipers that typically deliver herbicide through a wick or a tassle of wicks attached to a plastic re-fillable tube. Consult the registrant for the appropriate application method for your situation.

Use a backpack sprayer or a hand-held applicator, the

latter dedicated for S OLVI N IX ® LC application.

About an hour before application, remove the required number of frozen S OLVI N IX ® LC vials

from the freezer and allow the contents to thaw at room temperature. The vials may be thawed by
immersion in water at ROOM temperature. The
vials MUST NOT BE THAW ED by immersion in hot water or by direct heating as high temperature will destroy or inactivate S OLVI N IX ® LC . Add the
fully melted S OLVI N IX ® LC to the spray tank filled with about half of the final volume of water required for the spray. Triple rinse the vial with water and add the rinsate to the spray mix. Add water to bring the spray mix to the desired spray volume. Use clean potable water to mix with and apply S OLVI N IX ®

LC

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Alternatively, use only the required quantity from the vial by transferring at the rate of 1.5 ml of

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OLVI N IX ® LC per gallon of water (see Table below). Use the plastic liquid dispenser (Transfer Pipet) enclosed in the S OLVI N IX ® LC package to transfer when only a fraction of the vial’s content is required. Promptly re-freeze and store the unused

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OLVI N IX ® LC in the original vial, and the dispenser, for further use within the product’s expiration date. Do not melt and re-freeze the product
more than three times. IF THE 0.34 OZ (10 ML) SOLVINIX ® LC

VIAL IS TOO SMALL FOR YOUR NEEDS, BUY AND USE THE 1.2 OZ (35 ML) VIAL.

Apply S OLVI N IX ® LC to actively growing TSA plants at pre-flowering stage to prevent fruit-set and production of a new crop of seeds. For best results, apply in late spring or early summer in Florida and the Southeast. A single, properly directed application to a few young and healthy leaves per plant is
sufficient to allow the virus to infect and kill the entire plant.

Repeat applications will be necessary to treat plants that are missed in the first application or subsequently emerged plants. If there are still surviving plants after treatment, consider other
mechanical or chemical means of control. Consult
local extension recommendations and contact the registrant.

Do not apply S OLVI N IX ® LC if leaves are wet from rain or morning dew. Allow the leaves to dry before application.

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OLVI N IX ® LC can be applied in late summer or early fall to control late-emerging plants or plants that were missed in earlier applications. The plants must be actively growing when S OLVI N IX ® LC is applied; dormant or senescent plants may not respond normally to the virus and may not die.

For application with a high-pressure sprayer or a hand-held applicator, mix S OLVI N IX ® LC at the rate of 1.5 ml of per one gallon of water in a clean, pre-washed spray tank, a clean plastic bucket, or a clean one-gallon water jug*. Mix thoroughly before application. If using a hand-held applicator, carefully transfer and fill the app licator with the diluted

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OLVI N IX ® LC from the bucket or the jug.

*YOU MUST NOT USE A WASHED MILK JUG
BECAUSE ANY MILK RESIDUE PRESENT MAY
INACTIVATE THE VIRUS. Quantity of S OLVI N IX ® LC to Add To Amount of Water

1.5 Milliliters 1 Gallon

10 Milliliters - the entire content
of a 0.34-ounce vial 6.5 Gallons

35 Milliliters - the entire content
of a 1.2-ounce vial 23 GallonsSOLVINIX ® LC 10-ml vial 5 After mixing, do not allow S OLVI N IX ® LC to remain in the application tank for more than 24 hours or allow it to reach temperatures above 113°F (45°C). Avoid prolonged exposure of S OLVI N IX ®

LC to direct sunlight or heat.

The sprayer, namely the tank and the spray wand
combined, used for S OLVI N IX ® LC application

MUST BE CLEANED THOROUGHLY AND
IMMEDIATELY AFTER US E by: 1) flushing it twice by running clean water through and discharging the liquid on a Tropical Soda Appleplant; 2) then flushing it once with dilute dishwashing soap (2 tablespoons per gallon of water); and 3) finally flushing it twice with water.

REMARKS

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OLVI N IX ® LC must be used only against TSA since it is not effective against other weeds. Do not apply S OLVI N IX ® LC to TSA plants that are drought-stressed or dormant (i.e., not actively growing) or occur in waterlogged sites. Do not apply in late fall when nighttime temperatures begin to fall below 55°F (13°C) and if early frost is likely.

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OLVI N IX ® LC is effective only when applied post-emergence; it has no pre-emergence or soil residual activity against TSA. It would not be effective if applied via soil or irrigation water or any other method not specified in this label.

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OLVI N IX ® LC does not require the use of any additives or adjuvants. Do not mix it with any other
material not mentioned in this label.

***For any surviving treated Tropical Soda Apple ( Solanum viarum ) plants, re-apply according to label instructions. If there are still surviving plants,
consider other mechanical or chemical means of
control. Consult local extension recommendations and contact the registrant. The registrant will notify EPA under FIFRA 6(a)(2) for assessment of pesticide resistance in Tropical Soda Apple. WARRANTY AND DISCLAIMER OF
WARRANTIES BioProdex, Inc. warrants that S OLVI N IX ® LC conforms to the description and conditions on this label and that it will perform as indicated when used
under the directions and conditions of the label. BioProdex, Inc. and/or the seller makes no other expressed or implied warranty of fitness, merchantability, or otherwise. S OLVI N IX ® LC should provide satisfactory activity up to 12 months after purchase provided the product is stored at -4°F (-20°C). STORAGE AND DISPOSAL

Do not contaminate water, food, or feed by storage or disposal.

Pesticide Storage: Store S OLVI N IX ® LC in a freezer until it is ready to be used. Do not store

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OLVI N IX ® LC where food or medicine for human consumption is stored.

Pesticide Disposal: To avoid waste, use all material in this container by application according to label directions. If wastes cannot be avoided, offer remaining product to a waste disposal facility or pesticide disposal program (often such programs are run by state or local governments or by industry). DO NOT discharge

unused S OLVI N IX ® LC onto the ground, into water, or onto nontarget plants.

Container Handling: Non-refillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or
a mix tank. Fill the cont ainer 1⁄4 full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke.SOLVINIX ® LC 10-ml vial 6 LIMITATIONS OF LIABILITY It is the manufacturer’s intent that the liability of BioProdex, Inc. or of the seller for damages arising from the use of this product is limited to the replacement cost of the product used and shall not include any application costs or consequential damages such as loss of profits or other values.

NO CHANGES AUTHORIZED No one other than an authorized agent of BioProdex,
Inc. is allowed to make any other warranty or change the conditions, disclaimers, or limitations stated herein. Any authorization to make changes should be in writing and in specific reference to this label.

RIGHTS AND PRIVILEGES

** Use of TMGMV to control tropical soda apple by eliciting a lethal hypersensitive host response is protected under the Patent s US 6,689,718 B2 and US 7,494,955 B2. These patents are licensed to

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i o P r

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, I n c., 3131 NW 13 th Street, # 54, Gainesville, FL 32609-2183, USA TEL: 352-278-1572; FAX: 352-872-5035
Email: info@bioprodex.com ; Website: www.bioprodex.com

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