SAT Report

PMN Number: P-13-0874

SAT Date: 9/10/2013

Print Date: 6/4/2014

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2-3 2

 Persistence Bioaccum Toxicity Comments

1 12

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: SEVER IRR/POSS CORR E,S,MM,L

MUTA

LIVER

KIDNEY

BLOOD

SPLEEN

DEVEL

UNCERT NEURO

CHEM PNEUMONIA

AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-13-0874

FATE: 

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Solid with MP = 53 C (E)

log Kow = 4.06 (E) 

S = 84.3 mg/L at 25 C (E)

VP = 4.8E-3 torr at 25 C (E)

BP = 255 C (E)

H = 1.73E-6 (E)

log Koc = 3.39 (E)

log Fish BCF = 2.35 (E)

log Fish BAF = 1.91 (E) 

POTW removal (%) = 33 via sorption and possible partial biodeg

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = moderate

Volatilization half-life from a standard river = 440 hrs

Volatilization half-life from a standard lake = 200 da

Atmospheric Oxidation Half-life = 0.98 hr via OH radical

PBT Potential: P1B1

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Absorption is nil through the skin for the neat material, 

but poor through the skin for the material in solution, and poor through the lung and GI tract, 

based on physical/chemical properties.. There is concern for severe irritation/possible corrosion 

to all exposed tissues, based on information in the PMN MSDS, submitted test data, and 

. There is also concern for mutagenicity based on substituted phenols, which are 

positive in assays other than Salmonella. There are also concerns for liver, spleen, and kidney 

toxicities based on IRIS entries for ; blood toxicity and uncertain 

neurotoxicity, based on the IRIS entry for and developmental toxicity based 

on small substituted phenols. There is also concern for chemical pneumonia based on 

information in the PMN MSDS.

 Test Data: Submitted with 

Negative in Salmonella with and without activation; 

Negative in E. coli with and without activation; 

Acute oral ALD >11 g/kg; 

Mild dermal irritant in male rabbits; 

Moderate eye irritation in rabbits

Submitted with 

Nasal irritation at 670 mg/m3 in a 10-day inhalation study

Integrated Risk Information System (IRIS) data:

IRIS record for oral RfD 0.001 mg/kg/d, changes in blood pressure, liver, 

kidney, spleen toxicity at 14 mg/kg, NOEL 1.4 mg/kg;

IRIS record for oral RfD 0.0006 mg/kg/d, liver, kidney, spleen toxicity;

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IRIS record for oral RfD 0.02 mg/kg/d, hematological changes, clinical 

signs of lethargy, prostration, and ataxia

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 0.77

daphnid 48-h LC50 0.58

green algal 96-h EC50 2.2

fish _ chronic value 0.10

daphnid _ chronic 

value

0.11

algal _ chronic 

value

1.0

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for phenols; SAR chemical class 

= phenol; MW 164; log Kow = 4.06 (EPI); solid with mp unknown (P); S = 284 mg/L at 25 C 

(P); pH7; effective concentrations based on 100% active ingredients and mean measured 

concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

10

SARs phenols

SAR Class phenol

Ecotox Category Phenols

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat

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