### SAT Report PMN Number: P-13-0874 SAT Date: 9/10/2013 Print Date: 6/4/2014

Related cases : Health related cases: Ecotox related cases :

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 2-3 2

Persistence Bioaccum Toxicity Comments 1 12

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: SEVER IRR/POSS CORR E,S,MM,L MUTA LIVER KIDNEY BLOOD SPLEEN DEVEL UNCERT NEURO CHEM PNEUMONIA AQUATOX-A,C
Summary of Assessment :

Fate : Fate Summary: P-13-0874 FATE:Solid with MP = 53 C (E) log Kow = 4.06 (E) S = 84.3 mg/L at 25 C (E) VP = 4.8E-3 torr at 25 C (E) BP = 255 C (E) H = 1.73E-6 (E) log Koc = 3.39 (E) log Fish BCF = 2.35 (E) log Fish BAF = 1.91 (E) POTW removal (%) = 33 via sorption and possible partial biodeg Time for complete ultimate aerobic biodeg = wk-mo Sorption to soils/sediments = moderate Volatilization half-life from a standard river = 440 hrs Volatilization half-life from a standard lake = 200 da Atmospheric Oxidation Half-life = 0.98 hr via OH radical PBT Potential: P1B1 *CEB FATE: Migration to ground water = moderate

Health : Health Summary: Absorption is nil through the skin for the neat material, but poor through the skin for the material in solution, and poor through the lung and GI tract, based on physical/chemical properties.. There is concern for severe irritation/ p ossible corrosion to all exposed tissues, based on information in the PMN MSDS, submitted test data, and . There is also concern for mutagenicity based on substituted phenols, which are p ositive in assays other than Salmonella. There are also concerns for liver, spleen, and kidney toxicities based on IRIS entries for ; blood toxicity and uncertain neurotoxicity, based on the IRIS entry for and developmental toxicity based on small substituted phenols. There is also concern for chemical pneumonia based on information in the PMN MSDS. Test Data: Submitted with

N egative in Salmonella with and without activation; N egative in E. coli with and without activation; Acute oral ALD >11 g/kg; Mild dermal irritant in male rabbits; Moderate eye irritation in rabbits

Submitted with

N asal irritation at 670 mg/m3 in a 10-day inhalation study
Integrated Risk Information System (IRIS) data:

IRIS record for oral RfD 0.001 mg/kg/d, changes in blood pressure, liver, kidney, spleen toxicity at 14 mg/kg, N OEL 1.4 mg/kg; IRIS record for oral RfD 0.0006 mg/kg/d, liver, kidney, spleen toxicity;IRIS record for oral RfD 0.02 mg/kg/d, hematological changes, clinical signs of lethargy, p rostration, and ataxia

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 0.77 daphnid 48-h LC50 0.58 green algal 96-h EC50 2.2 fish

_ chronic value 0.10 daphnid

_ chronic value 0.11

algal

_ chronic value 1.0

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for phenols; SAR chemical class

= p henol; MW 164; log Kow = 4.06 (EPI); solid with mp unknown (P); S = 284 mg/L at 25 C (P); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 10

SARs p henols SAR Class p henol Ecotox Category Phenols

Ecotox Factors Comments:

SAT Chair: J. Kwiat