SolviNix® LC

MASTER LABEL

Sub-label A: 1.2 Fluid Ounces (35 ml) Vial

Sub-label B: 0.34 Fluid Ounce (10 ml) Vial
SolviNix® LC

Sub-label A: 1.2 Fluid Ounces (35 ml) Vial
SOLVINIX® LC 35-ml vial 1

EPA Reg. No.: 81179-G 

EPA Establishment No.: 081179-FL-001 

Batch Code: 

Use Before: 

NOT FOR SALE OR USE AFTER THE 

DATE STAMPED ABOVE 

SOLVINIX® LC

A Biological Herbicide for 

Control of Tropical Soda Apple 

(Solanum viarum)

For post-emergence application to kill 

tropical soda apple 

Active Ingredient: 

Tobacco mild green mosaic tobamovirus U2 

(TMGMV U2)...............2.9% w/v* 

 Other ingredients .............97.1% w/v 

 Total ........................ 100.0% w/v 

*Contains: A minimum of 0.03 ounce of the active 

ingredient, TMGMV U2, per fluid ounce of 

SolviNix® LC (29 milligrams of TMGMV U2 per ml 

of SolviNix® LC), with an estimated minimum of 

1.25 x 1016 TMGMV U2 virions per fluid ounce of 

SolviNix® LC (4.23 X 1014 TMGMV U2 virions per 

gram of SolviNix® LC). 

Net Contents: 1.2 fluid ounces (35 ml) 

For use only in pastures and wooded areas that 

are fenced to contain grazing animals 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC 

ANIMALS 

CAUTION 

Harmful if swallowed, absorbed through the skin, or 

inhaled. Causes moderate eye irritation. Avoid 

breathing spray mist. Avoid contact with skin, eyes, 

or clothing. Wash thoroughly with soap and water 

after handling and before eating, drinking, chewing 

gum, or using tobacco. Remove and wash 

contaminated clothing before reuse. 

FIRST AID 

If swallowed: 

 Call poison control center in your area or a 

doctor immediately for treatment advice. 

 Have person sip a glass of water if able to 

swallow. 

 Do not induce vomiting unless told to by the 

poison control center or the doctor. 

 Do not give anything to an unconscious person. 

If on skin or clothing: 

 Take off contaminated clothing. 

 Rinse skin immediately with plenty of water for 

15-20 minutes 

 Call poison control center or a doctor for 

treatment advice. 

If inhaled: 

 Move person to fresh air. 

 If person is not breathing, call 911 or an 

ambulance, and then give artificial respiration, 

preferably mouth-to-mouth if possible. 

 Call a poison control center or doctor for further 

treatment advice. 

If in eyes: 

 Hold eye open and rinse slowly and gently with 

water for 15-20 minutes. 

 Remove contact lenses, if present, after the first 

5 minutes, and then continue rinsing the eye. 

 Call poison control center or a doctor for 

treatment advice. 

Important: 

 Have the product container or label with you 

when calling doctor, or going for treatment. 

KEEP OUT OF REACH OF CHILDREN
SOLVINIX® LC 35-ml vial 2

ENVIRONMENTAL HAZARDS 

SOLVINIX® LC is intended for terrestrial uses only. 

Do not apply it directly to water, or to areas where 

surface water is present or to intertidal areas below 

the mean high water mark. Do not contaminate water 

when disposing equipment wash water. 

The virus in SOLVINIX® LC has no natural means 

of spread other than by physical and abrasive contact 

between infected and healthy plants. A remote 

possibility is through workers (via contaminated 

clothes, shoes, hands) and contaminated application 

equipment. To prevent unwanted virus spread, avoid 

contact with skin and clothing. Wash skin with soap 

and water and clothes with laundry detergent. See 

below instructions for washing application 

equipment. Thorough washing will prevent spread. 

STOP any pruning or mechanical activities in treated 

areas, such as mowing or tillage, 48 hours before, 

and after, application of SOLVINIX® LC. 

MAY INFECT SOME NON-WOODY 

FLOWERING PLANTS, INCLUDING 

SOLANACEOUS CROP PLANTS (EGGPLANT, 

PEPPER, TOBACCO, AND TOMATILLO).

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product 

in a manner inconsistent with its labeling. 

For use only in pastures and wooded areas that 

are fenced to contain grazing animals; with a 

backpack sprayer or a hand-held applicator, the 

latter dedicated for SOLVINIX® LC application 

only. 

For any surviving treated Tropical Soda Apple 

(Solanum viarum) plants, re-apply according to label 

instructions. If there are still surviving plants, 

consider other mechanical or chemical means of 

control. Consult local extension recommendations 

and contact the registrant. 

PRODUCT INFORMATION 

SOLVINIX® LC is a post-emergence bioherbicide 

for tropical soda apple (TSA). It contains a plant 

virus, Tobacco mild green mosaic tobamovirus Strain 

U2 (TMGMV), as the active ingredient. 

TMGMV kills TSA by triggering a systemic lethal 

hypersensitive plant response. To initiate this 

herbicidal action, the virus must enter the plant cells 

through minute injuries to the plant cell walls. The 

virus can then replicate and move from cell-to-cell, 

eliciting the hypersensitive response. To assure virus 

entry, SOLVINIX® LC is applied to TSA foliage 

with a high-pressure (80 psi), narrow-stream sprayer 

or a hand-held herbicide applicator as described 

below under APPLICATION INSTRUCTIONS. 

SOLVINIX® LC is sold and shipped in a frozen 

state. It should be kept frozen in a freezer until ready 

to be thawed and used. See Storage and Disposal 

section for further details. 

When properly applied using the specified method, 

SOLVINIX® LC will cause treated TSA plants to 

wilt in about 2-4 weeks after application followed by 

plant death. Brown leaf spots or flecks may appear on 

leaves directly exposed to the virus (i.e., inoculated 

leaves) in 3-5 days after inoculation and before the 

plant starts to wilt. The plants will die in a few days 

following initial wilting and the entire plant, 

including roots will be killed. Rarely, dying plants 

may sucker but the new growth will also be killed. 

USE RESTRICTIONS 

APPLY ONLY WHEN TROPICAL SODA APPLE 

PLANTS ARE ACTIVELY GROWING. 

DO NOT APPLY WITHIN 300 FEET OF 

GREENHOUSE AND GRAFTING OPERATIONS. 

SPRAY DIRECTLY AT THE TARGET PLANT 

- AVOID ANY CROPS AND NONTARGET 

PLANTS. 

MUST NOT RE-USE THE SPRAY EQUIPMENT 

FOR OTHER USES WITHOUT THOROUGH 

CLEANING AS SPECIFIED. 

DO NOT APPLY THIS PRODUCT THROUGH 

ANY TYPE OF IRRIGATION SYSTEM. 
SOLVINIX® LC 35-ml vial 3

Older plants may die more slowly than younger 

plants. 

In order for SOLVINIX® LC to be effective, the 

TSA plant must be healthy and vigorously growing 

when inoculated. Therefore, SOLVINIX® LC should 

be applied only to actively growing TSA plants. 

Considering this, SOLVINIX® LC will be sold 

seasonally to coincide with the annual growth cycle 

of TSA, from spring to early fall.

 

THE FOLLOWING PLANTS WERE SHOWN 

TO BE DAMAGED SLIGHTLY OR SEVERELY 

IF DIRECTLY EXPOSED TO SOLVINIX® LC: 

TMGMV is adapted to plants in the Solanaceae 

family. Of the 435 plant species screened by manual 

inoculation with TMGMV, the following plants 

developed infection symptoms: Common globe 

amaranth (Gomphrena globosa; family 

Amaranthaceae); rattlesnakemaster, eryngo, and 

plains eryngo (Eryngium aquaticum, E. dorae, and E. 

planum; Apiaceae); crape jasmine 

(Tabernaemontana divaricata; Apocynaceae); 

African daisy (Osteospermum sp. cv. Sheila; 

Asteraceae); balsams (Impatiens sp. cvs. Timor and 

Toyota; Balsaminaceae); salvation jane (Echium 

plantagineum; Boraginaceae); quinoa (Chenopodium 

quinoa; Chenopodiaceae); boatlily and inchplant 

(Tradescantia [=Rhoeo] spathacea and T. zebrina; 

Commelinaceae); Florida pusley (Richardia scabra; 

Rubiaceae); plants belonging to the Gesneriaceae

such as African violet (Saintpaulia spp.) and gloxinia 

(Sinningia spp.); wishbone flower (Torenia fournieri; 

Scrophulariaceae), and the following species in the 

Solanaceae: Jamaican forget-me-not (Browallia 

americana), trailing petunias (Calibrachoa spp. and 

Calibrachoa × hybrida), some cultivars of bell 

pepper (Capsicum annuum), some cultivars of scotch 

bonnet, ‘Aji dulce’, and Indian chili (C. chinense), 

jasmine tobacco (Nicotiana alata), Benthamiana 

tobacco (N. benthamiana), Cleveland’s tobacco (N. 

clevelandii), Debney's tobacco (N. debneyi), tree 

tobacco (N. glauca), glutinosa tobacco (N. glutinosa), 

Australian tobacco (Nicotiana hesperis), Native 

tobacco (Nicotiana occidentalis), some cultivars of 

commercial tobacco (N. tabacum), woodland tobacco 

(N. sylvestris), and two experimental hybrids: 

Edwardson’s tobacco (Nicotiana x edwardsonii) and

Sander’s tobacco (Nicotiana x sanderae), petunias 

(Petunia sp., Petunia sp. cv. Surfinia, Petunia x 

hybrida), violet-flower petunia (P. integrifolia), 

Chinese lantern (Physalis alkekengi), Downy groundcherry (Physalis floridana), cutleaf groundcherry (P. 

angulata), Mexican groundcherry (P. philadelphica), 

Walter’s groundcherry (P. walteri), needleleaf 

solanum (Solanum acerifolium), soda-apple 

nightshade (S. aculeatissimum), Ethiopian nightshade 

(S. aethiopicum), American black nightshade (S. 

americanum), Bahama nightshade (S. bahamense), 

cockroach berry (S. capsicoides), mamoncillo (S. 

caripense), twoleaf nightshade (S. diphyllum), 

Jamaican nightshade (S. jamaicense), earleaf 

nightshade (S. mauritianum), black nightshade (S. 

nigrum), hoe nightshade (S. physalifolium), husk 

tomato (Physalis pubescens), West Indian nightshade 

(S. ptycanthum), buffalobur nightshade (S. 

rostratum), hairy nightshade (S. sarrachoides), sticky 

nightshade (S. sisymbriifolium), spiny solanum (S. 

spinosissimum), fragrant solanum (S. suaveolens), 

and hairy nightshade (S. villosum). 

APPLICATION RATE 

SOLVINIX® LC is packaged in 1.2 ounces (35 ml) 

quantity in a 50 ml plastic screw-cap vial. Apply 

SOLVINIX® LC at the rate of 1.5 ml per gallon of 

water (~10 micrograms of active ingredient per ml). 

Each 50 ml vial containing 35 ml SOLVINIX® LC

should be sufficient to treat approximately 2500 TSA 

plants with a backpack sprayer set at 80 psi and at a 

volume of 20 to 40 ml (approximately 0.7 to 1.5 

ounces) per plant. 

The amount of SOLVINIX® LC needed to treat an 

area and application volume will depend on the 

density of TSA infestation, distribution pattern, 

application method, applicator efficiency, height of 

grass stand, terrain, and other likely factors.

APPLICATION INSTRUCTIONS 

Use the following methods to apply SOLVINIX®

LC: 1) With a high-pressure backpack sprayer 

delivering a narrow jet of spray at 80 psi at the point 

of impact on TSA leaves. Ideally, the distance from 

the nozzle to the leaves should be about 12 to 18 

inches. Application with a conventional backpack 

sprayer having a 3-foot wand and a Quick TeeJet 

Cap containing a D-1 or D-2 orifice plate and a 

rubber O-ring gasket yields good foliage penetration. 

2) With a hand-held herbicide applicator for scattered 

TSA infestations. Hand-held applicators include 
SOLVINIX® LC 35-ml vial 4

commercially available herbicide wipers that 

typically deliver herbicide through a wick or a tassle 

of wicks attached to a plastic re-fillable tube. Consult 

the registrant for the appropriate application method 

for your situation. 

Use a backpack sprayer or a hand-held applicator, the 

latter dedicated for SOLVINIX® LC application. 

About an hour before application, remove the 

required number of frozen SOLVINIX® LC vials 

from the freezer and allow the contents to thaw at 

room temperature. The vials may be thawed by 

immersion in water at ROOM temperature. The 

vials MUST NOT BE THAWED by immersion in 

hot water or by direct heating as high temperature 

will destroy or inactivate SOLVINIX® LC. Add the 

fully melted SOLVINIX® LC to the spray tank filled 

with about half of the final volume of water required 

for the spray. Triple rinse the vial with water and add 

the rinsate to the spray mix. Add water to bring the 

spray mix to the desired spray volume. Use clean 

potable water to mix with and apply SOLVINIX®

LC. 

Alternatively, use only the required quantity from the 

vial by transferring at the rate of 1.5 ml of 

SOLVINIX® LC per gallon of water (see Table 

below). Use the plastic liquid dispenser (Transfer 

Pipet) enclosed in the SOLVINIX® LC package to 

transfer when only a fraction of the vial’s content is 

required. Promptly re-freeze and store the unused 

SOLVINIX® LC in the original vial, and the 

dispenser, for further use within the product’s 

expiration date. Do not melt and re-freeze the product 

more than three times. 

IF THE 1.2 OZ (35 ML) SOLVINIX® LC VIAL 

IS TOO LARGE FOR YOUR NEEDS, BUY AND 

USE THE 0.34 OZ (10 ML) VIAL. 

Apply SOLVINIX® LC to actively growing TSA 

plants at pre-flowering stage to prevent fruit-set and 

production of a new crop of seeds. For best results, 

apply in late spring or early summer in Florida and 

the Southeast. A single, properly directed application 

to a few young and healthy leaves per plant is 

sufficient to allow the virus to infect and kill the 

entire plant. 

Repeat applications will be necessary to treat plants 

that are missed in the first application or 

subsequently emerged plants. If there are still 

surviving plants after treatment, consider other 

mechanical or chemical means of control. Consult 

local extension recommendations and contact the 

registrant. 

Do not apply SOLVINIX® LC if leaves are wet from 

rain or morning dew. Allow the leaves to dry before 

application. 

SOLVINIX® LC can be applied in late summer or 

early fall to control late-emerging plants or plants 

that were missed in earlier applications. The plants 

must be actively growing when SOLVINIX® LC is 

applied; dormant or senescent plants may not 

respond normally to the virus and may not die. 

For application with a high-pressure sprayer or a 

hand-held applicator, mix SOLVINIX® LC at the 

rate of 1.5 ml of per one gallon of water in a clean, 

pre-washed spray tank, a clean plastic bucket, or a 

clean one-gallon water jug*. Mix thoroughly before 

application. If using a hand-held applicator, carefully 

transfer and fill the applicator with the diluted 

SOLVINIX® LC from the bucket or the jug. 

*YOU MUST NOT USE A WASHED MILK JUG 

BECAUSE ANY MILK RESIDUE PRESENT MAY 

INACTIVATE THE VIRUS. 

Quantity of SOLVINIX® LC to Add To Amount of Water 

1.5 Milliliters 1 Gallon 

10 Milliliters - the entire content 

of a 0.34-ounce vial 6.5 Gallons 

35 Milliliters - the entire content 

of a 1.2-ounce vial 23 Gallons 
SOLVINIX® LC 35-ml vial 5

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by 

storage or disposal. 

Pesticide Storage: Store SOLVINIX® LC in a 

freezer until it is ready to be used. Do not store 

SOLVINIX® LC where food or medicine for 

human consumption is stored. 

Pesticide Disposal: To avoid waste, use all 

material in this container by application 

according to label directions. If wastes cannot be 

avoided, offer remaining product to a waste 

disposal facility or pesticide disposal program 

(often such programs are run by state or local 

governments or by industry). DO NOT discharge 

unused SOLVINIX® LC onto the ground, into 

water, or onto nontarget plants. 

Container Handling: Non-refillable container. 

Do not reuse or refill this container. Triple rinse 

container (or equivalent) promptly after 

emptying. Triple rinse as follows: Empty the 

remaining contents into application equipment or 

a mix tank. Fill the container 1⁄4 full with water 

and recap. Shake for 10 seconds. Pour rinsate into 

application equipment or a mix tank or store 

rinsate for later use or disposal. Drain for 10 

seconds after the flow begins to drip. Repeat this 

procedure two more times. Then offer for 

recycling if available or puncture and dispose of 

in a sanitary landfill, or by incineration, or, if 

allowed by state and local authorities, by burning. 

If burned, stay out of smoke. 

After mixing, do not allow SOLVINIX® LC to 

remain in the application tank for more than 24 hours 

or allow it to reach temperatures above 113°F 

(45°C). Avoid prolonged exposure of SOLVINIX®

LC to direct sunlight or heat. 

The sprayer, namely the tank and the spray wand 

combined, used for SOLVINIX® LC application 

MUST BE CLEANED THOROUGHLY AND 

IMMEDIATELY AFTER USE by: 1) flushing it 

twice by running clean water through and 

discharging the liquid on a Tropical Soda Apple 

plant; 2) then flushing it once with dilute dishwashing soap (2 tablespoons per gallon of water); 

and 3) finally flushing it twice with water. 

REMARKS 

SOLVINIX® LC must be used only against TSA 

since it is not effective against other weeds. Do not 

apply SOLVINIX® LC to TSA plants that are 

drought-stressed or dormant (i.e., not actively 

growing) or occur in waterlogged sites. Do not apply 

in late fall when nighttime temperatures begin to fall 

below 55°F (13°C) and if early frost is likely. 

SOLVINIX® LC is effective only when applied 

post-emergence; it has no pre-emergence or soil 

residual activity against TSA. It will not be effective 

if applied via soil or irrigation water or any other 

method not specified in this label. 

SOLVINIX® LC does not require the use of any 

additives or adjuvants. Do not mix it with any other 

material not mentioned in this label.

***For any surviving treated Tropical Soda Apple 

(Solanum viarum) plants, re-apply according to label 

instructions. If there are still surviving plants, 

consider other mechanical or chemical means of 

control. Consult local extension recommendations 

and contact the registrant. The registrant will notify 

EPA under FIFRA 6(a)(2) for assessment of 

pesticide resistance in Tropical Soda Apple. 

WARRANTY AND DISCLAIMER OF 

WARRANTIES 

BioProdex, Inc. warrants that SOLVINIX® LC

conforms to the description and conditions on this 

label and that it will perform as indicated when used 

under the directions and conditions of the label. 

BioProdex, Inc. and/or the seller makes no other 

expressed or implied warranty of fitness, 

merchantability, or otherwise. SOLVINIX® LC

should provide satisfactory activity up to 12 months 

after purchase provided the product is stored at -4°F 

(-20°C). 
SOLVINIX® LC 35-ml vial 6

LIMITATIONS OF LIABILITY

It is the manufacturer’s intent that the liability of 

BioProdex, Inc. or of the seller for damages arising 

from the use of this product is limited to the 

replacement cost of the product used and shall not 

include any application costs or consequential 

damages such as loss of profits or other values. 

NO CHANGES AUTHORIZED 

No one other than an authorized agent of BioProdex, 

Inc. is allowed to make any other warranty or change 

the conditions, disclaimers, or limitations stated 

herein. Any authorization to make changes should be 

in writing and in specific reference to this label. 

RIGHTS AND PRIVILEGES 

**Use of TMGMV to control tropical soda apple by 

eliciting a lethal hypersensitive host response is 

protected under the Patents US 6,689,718 B2 and US 

7,494,955 B2. These patents are licensed to 

BioProdex, Inc.

BioProdex, Inc., 3131 NW 13th Street, # 54, Gainesville, FL 32609-2183, USA 

TEL: 352-278-1572; FAX: 352-872-5035 

Email: info@bioprodex.com; Website: www.bioprodex.com. 
SolviNix® LC

Sub-label B: 0.34 Fluid Ounce (10 ml) Vial
SOLVINIX® LC 10-ml vial 1 

 

EPA Reg. No.: 81179-G 

EPA Establishment No.: 081179-FL-001 

Batch Code: 

Use Before: 

NOT FOR SALE OR USE AFTER THE 

DATE STAMPED ABOVE 

SOLVINIX® LC

A Biological Herbicide for 

Control of Tropical Soda Apple 

(Solanum viarum)

For post-emergence application to kill 

tropical soda apple 

Active Ingredient: 

 Tobacco mild green mosaic tobamovirus U2 

(TMGMV U2).....................2.9% w/v* 

 Other ingredients ................97.1% w/v 

 Total ........................... 100.0% w/v 

*Contains: A minimum of 0.03 ounce of the active 

ingredient, TMGMV U2, per fluid ounce of 

SolviNix® LC (29 milligrams of TMGMV U2 per ml 

of SolviNix® LC), with an estimated minimum of 

1.25 x 1016 TMGMV U2 virions per fluid ounce of 

SolviNix® LC (4.23 X 1014 TMGMV U2 virions per 

gram of SolviNix® LC). 

Net Contents: 0.34 fluid ounce (10 ml) 

For use only in pastures and wooded areas that 

are fenced to contain grazing animals 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC 

ANIMALS 

CAUTION 

Harmful if swallowed, absorbed through the skin, or 

inhaled. Causes moderate eye irritation. Avoid 

breathing spray mist. Avoid contact with skin, eyes, 

or clothing. Wash thoroughly with soap and water 

after handling and before eating, drinking, chewing 

gum, or using tobacco. Remove and wash 

contaminated clothing before reuse. 

FIRST AID 

If swallowed: 

 Call poison control center in your area or a 

doctor immediately for treatment advice. 

 Have person sip a glass of water if able to 

swallow. 

 Do not induce vomiting unless told to by the 

poison control center or the doctor. 

 Do not give anything to an unconscious person. 

If on skin or clothing: 

 Take off contaminated clothing. 

 Rinse skin immediately with plenty of water for 

15-20 minutes 

 Call poison control center or a doctor for 

treatment advice. 

If inhaled: 

 Move person to fresh air. 

 If person is not breathing, call 911 or an 

ambulance, and then give artificial respiration, 

preferably mouth-to-mouth if possible. 

 Call a poison control center or doctor for further 

treatment advice. 

If in eyes: 

 Hold eye open and rinse slowly and gently with 

water for 15-20 minutes. 

 Remove contact lenses, if present, after the first 

5 minutes, and then continue rinsing the eye. 

 Call poison control center or a doctor for 

treatment advice. 

Important: 

 Have the product container or label with you 

when calling doctor, or going for treatment. 

KEEP OUT OF REACH OF CHILDREN
SOLVINIX® LC 10-ml vial 2 

 

ENVIRONMENTAL HAZARDS 

SOLVINIX® LC is intended for terrestrial uses only. 

Do not apply it directly to water, or to areas where 

surface water is present or to intertidal areas below 

the mean high water mark. Do not contaminate water 

when disposing equipment wash water. 

The virus in SOLVINIX® LC has no natural means 

of spread other than by physical and abrasive contact 

between infected and healthy plants. A remote 

possibility is through workers (via contaminated 

clothes, shoes, hands) and contaminated application 

equipment. To prevent unwanted virus spread, avoid 

contact with skin and clothing. Wash skin with soap 

and water and clothes with laundry detergent. See 

below instructions for washing application 

equipment. Thorough washing will prevent spread. 

STOP any pruning or mechanical activities in treated 

areas, such as mowing or tillage, 48 hours before, 

and after, application of SOLVINIX® LC.

MAY INFECT SOME NON-WOODY 

FLOWERING PLANTS, INCLUDING 

SOLANACEOUS CROP PLANTS (EGGPLANT, 

PEPPER, TOBACCO, AND TOMATILLO). 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product 

in a manner inconsistent with its labeling. 

For use only in pastures and wooded areas that 

are fenced to contain grazing animals; with a 

backpack sprayer or a hand-held applicator, the 

latter dedicated for SOLVINIX® LC application 

only. 

For any surviving treated Tropical Soda Apple 

(Solanum viarum) plants, re-apply according to label 

instructions. If there are still surviving plants, 

consider other mechanical or chemical means of 

control. Consult local extension recommendations 

and contact the registrant. 

. 

PRODUCT INFORMATION 

SOLVINIX® LC is a post-emergence bioherbicide 

for tropical soda apple (TSA). It contains a plant 

virus, Tobacco mild green mosaic tobamovirus Strain 

U2 (TMGMV), as the active ingredient. 

TMGMV kills TSA by triggering a systemic lethal 

hypersensitive plant response. To initiate this 

herbicidal action, the virus must enter the plant cells 

through minute injuries to the plant cell walls. The 

virus can then replicate and move from cell-to-cell, 

eliciting the hypersensitive response. To assure virus 

entry, SOLVINIX® LC is applied to TSA foliage 

with a high-pressure (80 psi), narrow-stream sprayer 

or a hand-held herbicide applicator as described 

below under APPLICATION INSTRUCTIONS. 

SOLVINIX® LC is sold and shipped in a frozen 

state. It should be kept frozen in a freezer until ready 

to be thawed and used. See Storage and Disposal 

section for further details. 

When properly applied using the specified method, 

SOLVINIX® LC will cause treated TSA plants to 

wilt in about 2-4 weeks after application followed by 

plant death. Brown leaf spots or flecks may appear 

on leaves directly exposed to the virus (i.e., 

inoculated leaves) in 3-5 days after inoculation and 

before the plant starts to wilt. The plants will die in a 

few days following initial wilting and the entire 

plant, including roots will be killed. Rarely, dying 

plants may sucker but the new growth will also be 

USE RESTRICTIONS 

APPLY ONLY WHEN TROPICAL SODA APPLE 

PLANTS ARE ACTIVELY GROWING. 

DO NOT APPLY WITHIN 300 FEET OF 

GREENHOUSE AND GRAFTING OPERATIONS. 

SPRAY DIRECTLY AT THE TARGET PLANT 

- AVOID ANY CROPS AND NONTARGET 

PLANTS. 

MUST NOT RE-USE THE SPRAY EQUIPMENT 

FOR OTHER USES WITHOUT THOROUGH 

CLEANING AS SPECIFIED. 

DO NOT APPLY THIS PRODUCT THROUGH 

ANY TYPE OF IRRIGATION SYSTEM. 
SOLVINIX® LC 10-ml vial 3 

 

killed. Older plants may die more slowly than 

younger plants. 

In order for SOLVINIX® LC to be effective, the 

TSA plant must be healthy and vigorously growing 

when inoculated. Therefore, SOLVINIX® LC should 

be applied only to actively growing TSA plants. 

Considering this, SOLVINIX® LC will be sold 

seasonally to coincide with the annual growth cycle 

of TSA, from spring to early fall.

 

THE FOLLOWING PLANTS WERE SHOWN 

TO BE DAMAGED SLIGHTLY OR SEVERELY 

IF DIRECTLY EXPOSED TO SOLVINIX® LC: 

TMGMV is adapted to plants in the Solanaceae 

family. Of the 435 plant species screened by manual 

inoculation with TMGMV, the following plants 

developed infection symptoms: Common globe 

amaranth (Gomphrena globosa; family 

Amaranthaceae); rattlesnakemaster, eryngo, and 

plains eryngo (Eryngium aquaticum, E. dorae, and E. 

planum; Apiaceae); crape jasmine 

(Tabernaemontana divaricata; Apocynaceae); 

African daisy (Osteospermum sp. cv. Sheila; 

Asteraceae); balsams (Impatiens sp. cvs. Timor and 

Toyota; Balsaminaceae); salvation jane (Echium 

plantagineum; Boraginaceae); quinoa (Chenopodium 

quinoa; Chenopodiaceae); boatlily and inchplant 

(Tradescantia [=Rhoeo] spathacea and T. zebrina; 

Commelinaceae); Florida pusley (Richardia scabra; 

Rubiaceae); plants belonging to the Gesneriaceae

such as African violet (Saintpaulia spp.) and gloxinia 

(Sinningia spp.); wishbone flower (Torenia fournieri; 

Scrophulariaceae), and the following species in the 

Solanaceae: Jamaican forget-me-not (Browallia 

americana), trailing petunias (Calibrachoa spp. and 

Calibrachoa × hybrida), some cultivars of bell 

pepper (Capsicum annuum), some cultivars of scotch 

bonnet, ‘Aji dulce’, and Indian chili (C. chinense), 

jasmine tobacco (Nicotiana alata), Benthamiana 

tobacco (N. benthamiana), Cleveland’s tobacco (N. 

clevelandii), Debney's tobacco (N. debneyi), tree 

tobacco (N. glauca), glutinosa tobacco (N. glutinosa), 

Australian tobacco (Nicotiana hesperis), Native 

tobacco (Nicotiana occidentalis), some cultivars of 

commercial tobacco (N. tabacum), woodland tobacco 

(N. sylvestris), and two experimental hybrids: 

Edwardson’s tobacco (Nicotiana x edwardsonii) and

Sander’s tobacco (Nicotiana x sanderae), petunias 

(Petunia sp., Petunia sp. cv. Surfinia, Petunia x 

hybrida), violet-flower petunia (P. integrifolia), 

Chinese lantern (Physalis alkekengi), Downy groundcherry (Physalis floridana), cutleaf groundcherry (P. 

angulata), Mexican groundcherry (P. philadelphica), 

Walter’s groundcherry (P. walteri), needleleaf 

solanum (Solanum acerifolium), soda-apple 

nightshade (S. aculeatissimum), Ethiopian nightshade 

(S. aethiopicum), American black nightshade (S. 

americanum), Bahama nightshade (S. bahamense), 

cockroach berry (S. capsicoides), mamoncillo (S. 

caripense), twoleaf nightshade (S. diphyllum), 

Jamaican nightshade (S. jamaicense), earleaf 

nightshade (S. mauritianum), black nightshade (S. 

nigrum), hoe nightshade (S. physalifolium), husk 

tomato (Physalis pubescens), West Indian nightshade 

(S. ptycanthum), buffalobur nightshade (S. 

rostratum), hairy nightshade (S. sarrachoides), sticky 

nightshade (S. sisymbriifolium), spiny solanum (S. 

spinosissimum), fragrant solanum (S. suaveolens), 

and hairy nightshade (S. villosum). 

APPLICATION RATE 

SOLVINIX® LC is packaged in 0.34 ounce (10 ml) 

quantity in a 15 ml plastic screw-cap vial. Apply 

SOLVINIX® LC at the rate of 1.5 ml per gallon of 

water (~10 micrograms of active ingredient per ml). 

Each 15 ml vial containing 10 ml SOLVINIX® LC

should be sufficient to treat approximately 600 TSA 

plants with a backpack sprayer set at 80 psi and at a 

volume of 20 to 40 ml (approximately 0.7 to 1.5 

ounces) per plant. 

The amount of SOLVINIX® LC needed to treat an 

area and application volume will depend on the 

density of TSA infestation, distribution pattern, 

application method, applicator efficiency, height of 

grass stand, terrain, and other likely factors. 

APPLICATION INSTRUCTIONS 

Use the following methods to apply SOLVINIX®

LC: 1) With a high-pressure backpack sprayer 

delivering a narrow jet of spray at 80 psi at the point 

of impact on TSA leaves. Ideally, the distance from 

the nozzle to the leaves should be about 12 to 18 

inches. Application with a conventional backpack 

sprayer having a 3-foot wand and a Quick TeeJet 

Cap containing a D-1 or D-2 orifice plate and a 

rubber O-ring gasket yields good foliage penetration. 

2) With a hand-held herbicide applicator for scattered 
SOLVINIX® LC 10-ml vial 4 

 

TSA infestations. Hand-held applicators include 

commercially available herbicide wipers that 

typically deliver herbicide through a wick or a tassle 

of wicks attached to a plastic re-fillable tube. Consult 

the registrant for the appropriate application method 

for your situation. 

Use a backpack sprayer or a hand-held applicator, the 

latter dedicated for SOLVINIX® LC application. 

About an hour before application, remove the 

required number of frozen SOLVINIX® LC vials 

from the freezer and allow the contents to thaw at 

room temperature. The vials may be thawed by 

immersion in water at ROOM temperature. The 

vials MUST NOT BE THAWED by immersion in 

hot water or by direct heating as high temperature 

will destroy or inactivate SOLVINIX® LC. Add the 

fully melted SOLVINIX® LC to the spray tank filled 

with about half of the final volume of water required 

for the spray. Triple rinse the vial with water and add 

the rinsate to the spray mix. Add water to bring the 

spray mix to the desired spray volume. Use clean 

potable water to mix with and apply SOLVINIX®

LC. 

Alternatively, use only the required quantity from the 

vial by transferring at the rate of 1.5 ml of 

SOLVINIX® LC per gallon of water (see Table 

below). Use the plastic liquid dispenser (Transfer 

Pipet) enclosed in the SOLVINIX® LC package to 

transfer when only a fraction of the vial’s content is 

required. Promptly re-freeze and store the unused 

SOLVINIX® LC in the original vial, and the 

dispenser, for further use within the product’s 

expiration date. Do not melt and re-freeze the product 

more than three times. 

IF THE 0.34 OZ (10 ML) SOLVINIX® LC 

VIAL IS TOO SMALL FOR YOUR NEEDS, 

BUY AND USE THE 1.2 OZ (35 ML) VIAL.

Apply SOLVINIX® LC to actively growing TSA 

plants at pre-flowering stage to prevent fruit-set and 

production of a new crop of seeds. For best results, 

apply in late spring or early summer in Florida and 

the Southeast. A single, properly directed application 

to a few young and healthy leaves per plant is 

sufficient to allow the virus to infect and kill the 

entire plant. 

Repeat applications will be necessary to treat plants 

that are missed in the first application or 

subsequently emerged plants. If there are still 

surviving plants after treatment, consider other 

mechanical or chemical means of control. Consult 

local extension recommendations and contact the 

registrant. 

Do not apply SOLVINIX® LC if leaves are wet from 

rain or morning dew. Allow the leaves to dry before 

application. 

SOLVINIX® LC can be applied in late summer or 

early fall to control late-emerging plants or plants 

that were missed in earlier applications. The plants 

must be actively growing when SOLVINIX® LC is 

applied; dormant or senescent plants may not 

respond normally to the virus and may not die. 

For application with a high-pressure sprayer or a 

hand-held applicator, mix SOLVINIX® LC at the 

rate of 1.5 ml of per one gallon of water in a clean, 

pre-washed spray tank, a clean plastic bucket, or a 

clean one-gallon water jug*. Mix thoroughly before 

application. If using a hand-held applicator, carefully 

transfer and fill the applicator with the diluted 

SOLVINIX® LC from the bucket or the jug. 

*YOU MUST NOT USE A WASHED MILK JUG 

BECAUSE ANY MILK RESIDUE PRESENT MAY 

INACTIVATE THE VIRUS. 

Quantity of SOLVINIX® LC to Add To Amount of Water 

1.5 Milliliters 1 Gallon 

10 Milliliters - the entire content 

of a 0.34-ounce vial 6.5 Gallons 

35 Milliliters - the entire content 

of a 1.2-ounce vial 23 Gallons 
SOLVINIX® LC 10-ml vial 5 

 

After mixing, do not allow SOLVINIX® LC to 

remain in the application tank for more than 24 hours 

or allow it to reach temperatures above 113°F 

(45°C). Avoid prolonged exposure of SOLVINIX®

LC to direct sunlight or heat. 

The sprayer, namely the tank and the spray wand 

combined, used for SOLVINIX® LC application 

MUST BE CLEANED THOROUGHLY AND 

IMMEDIATELY AFTER USE by: 1) flushing it 

twice by running clean water through and 

discharging the liquid on a Tropical Soda Apple 

plant; 2) then flushing it once with dilute dishwashing soap (2 tablespoons per gallon of water); 

and 3) finally flushing it twice with water. 

REMARKS 

SOLVINIX® LC must be used only against TSA 

since it is not effective against other weeds. Do not 

apply SOLVINIX® LC to TSA plants that are 

drought-stressed or dormant (i.e., not actively 

growing) or occur in waterlogged sites. Do not apply 

in late fall when nighttime temperatures begin to fall 

below 55°F (13°C) and if early frost is likely. 

SOLVINIX® LC is effective only when applied 

post-emergence; it has no pre-emergence or soil 

residual activity against TSA. It would not be 

effective if applied via soil or irrigation water or any 

other method not specified in this label. 

SOLVINIX® LC does not require the use of any 

additives or adjuvants. Do not mix it with any other 

material not mentioned in this label. 

***For any surviving treated Tropical Soda Apple 

(Solanum viarum) plants, re-apply according to label 

instructions. If there are still surviving plants, 

consider other mechanical or chemical means of 

control. Consult local extension recommendations 

and contact the registrant. The registrant will notify 

EPA under FIFRA 6(a)(2) for assessment of 

pesticide resistance in Tropical Soda Apple. 

WARRANTY AND DISCLAIMER OF 

WARRANTIES 

BioProdex, Inc. warrants that SOLVINIX® LC

conforms to the description and conditions on this 

label and that it will perform as indicated when used 

under the directions and conditions of the label. 

BioProdex, Inc. and/or the seller makes no other 

expressed or implied warranty of fitness, 

merchantability, or otherwise. SOLVINIX® LC

should provide satisfactory activity up to 12 months 

after purchase provided the product is stored at -4°F 

(-20°C). 

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by 

storage or disposal. 

Pesticide Storage: Store SOLVINIX® LC in a 

freezer until it is ready to be used. Do not store 

SOLVINIX® LC where food or medicine for 

human consumption is stored. 

Pesticide Disposal: To avoid waste, use all 

material in this container by application 

according to label directions. If wastes cannot be 

avoided, offer remaining product to a waste 

disposal facility or pesticide disposal program 

(often such programs are run by state or local 

governments or by industry). DO NOT discharge 

unused SOLVINIX® LC onto the ground, into 

water, or onto nontarget plants. 

Container Handling: Non-refillable container. 

Do not reuse or refill this container. Triple rinse 

container (or equivalent) promptly after 

emptying. Triple rinse as follows: Empty the 

remaining contents into application equipment or 

a mix tank. Fill the container 1⁄4 full with water 

and recap. Shake for 10 seconds. Pour rinsate 

into application equipment or a mix tank or store 

rinsate for later use or disposal. Drain for 10 

seconds after the flow begins to drip. Repeat this 

procedure two more times. Then offer for 

recycling if available or puncture and dispose of 

in a sanitary landfill, or by incineration, or, if 

allowed by state and local authorities, by 

burning. If burned, stay out of smoke. 
SOLVINIX® LC 10-ml vial 6 

 

LIMITATIONS OF LIABILITY

It is the manufacturer’s intent that the liability of 

BioProdex, Inc. or of the seller for damages arising 

from the use of this product is limited to the 

replacement cost of the product used and shall not 

include any application costs or consequential 

damages such as loss of profits or other values. 

NO CHANGES AUTHORIZED 

No one other than an authorized agent of BioProdex, 

Inc. is allowed to make any other warranty or change 

the conditions, disclaimers, or limitations stated 

herein. Any authorization to make changes should be 

in writing and in specific reference to this label. 

RIGHTS AND PRIVILEGES 

**Use of TMGMV to control tropical soda apple by 

eliciting a lethal hypersensitive host response is 

protected under the Patents US 6,689,718 B2 and US 

7,494,955 B2. These patents are licensed to 

BioProdex, Inc.

BioProdex, Inc., 3131 NW 13th Street, # 54, Gainesville, FL 32609-2183, USA 

TEL: 352-278-1572; FAX: 352-872-5035 

Email: info@bioprodex.com; Website: www.bioprodex.com.