### Appendix B. Table of Generic Data Requirements and Studies Used to Make the

**Reregistration Decision for Metam** **- sodium, Metam** **- potassium, and MITC**  **(PC 039003, 039002, 068103**  **)** GUIDE TO APPENDIX B Appendix B contains a listing of data requirements which support the reregistration for active ingredients within the case covered b y this RED. It contains generic data requirements that apply to metam- sodium, metam -potassium, and MITC in all products, including data requirements for which a “typical formulation” is the test substance. The data table is organized in the following formats: 1. Data requirement (Column 1). The data requirements are listed in the order in which they

appear in 40 CFR 158. The reference numbers accompanying each te st refer to the test protocols set in the Pesticide Assessment Guidance, which is available from the National Technical Information Service, 5285 Port Royal Road, Springfield, VA 22161. (703) 487 - 4650. 2. Use Pattern (Column 2). This column indicates the u se patterns for which the data requirements apply. The following letter designations are used for the given use patterns. A. Terrestrial food B. Terrestrial feed C. Terrestrial non- food D. Aquatic food E. Aquatic non- food outdoor F. Aquatic non- food industrial G. Aquatic non- food residential H. Greenhouse food I. Greenhouse non- food J. Forestry K. Residential L. Indoor food M. Indoor non- food N. Indoor medical O. Indoor residential X . Materials preservatives Y. Industrial processes and water s ystems - once through Z. Industrial proc esses and water systems -not once through BB. Wood preservatives FF. High Exposure Antimicrobial GG. Low Exposure Antimicrobial 3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this column lists the identifying number of each study . This normally is the Master Record Identification (MRID) number, but may be a “GS” number is no MRID number has been assigned. Refer to the Bibliography appendix for a complete citation of the study .**Data Requirement Use Patterns**  **Ci tations**  **New Guideline Number Old**  **Guideline Number**  **Description PRODUCT CHEMISTRY**  830.1600 61 - 2A Description of materials used to produce the product ALL 41241601, 44453602 , 00162081 , 44459101 , 43953901 830.1620 61 - 2B Description of production process ALL 41241601, 44453602, 00162081, 44459101, 43953901 830.1670 61 - 2B Formation of Impurities ALL 41241601, 44453602, 00162081, 43953901 830.1700 62 - 1 Preliminary Analysis ALL 41241602, 44453603, 00162080 830.6302 63 - 2 Color ALL 41241603, 41286003, 001620 79 , 45919401 830.6303 63 - 3 Physical State ALL 41241603, 41286003, 43457708, 00162079 , 45919401 830.6304 63 - 4 Odor 1 ALL 41241603, 41286003, 43457708, 00162079 , 45919401 830.6313 63 - 13 Stability to normal and elevated tem peratures, metals, and metal ions ALL 41241603, 41286003, 00162079 830.7000 63 - 12 pH ALL 41241603, 41286003, 43457708, 00162079 830.7050 None UV/Visible Absorption ALL 45919401, 45919401, DATA GAP 830.7200 Melting Point/melting range ALL 45919401 830.7220 63 - 6 Boiling Point/boiling range ALL 41241603, 41286003, 45919401 830.7300 63 - 7 Density ALL 41241603, 41286003, 43457708, 00162079 , 45919401 830.7370 63 - 10 Dissociation Constants in Water ALL 41241603, 41286003, 45919404, 830.7550 63 - 11 Partition coefficient, shake flask method ALL 41241603, 41286003, 45919401 830.7840 63 - 8 Water solubility: column elution method; shake flask method ALL 41241603, 41286003, 45919401, 45919403 830.7950 63 - 9 Vapor Pressure ALL 41241603, 41286003, 45919401 **ECOLOGICAL EFFECTS** 850.1010 72 - 2 Acute Toxicity to Freshwater Invertebrates ALL 41106203, 40098001, 42680601, 41819302, 45919419 850.1025 72 - 3B Estuarine/Marine Toxicity

– Mollusk ALL 42632201 , DATA GAP 850.1035 72 - 3C Estuarine/Marine Toxicity

– ALL 42476301 , 43457708,**Data Requirement Use Patterns**  **Ci tations**  **New Guideline Number Old**  **Guideline Number**  **Description**

Shrimp DATA GAP 850 .1075 72 - 1A Fish Acute Toxicity Bluegill ALL 42363201, 44523412 , DATA GAP 850.1075 72 - 1B Fish Acute Toxicity

– Rainbow Trout ALL 42363202, 44523413, 45919420 850.1075 72 - 3A Estuarine/Marine Toxicity

– Fish ALL 42436301 , DATA GAP 850.1300 Aquatic Invertebrate Lifecycle (Freshwater) ALL 45634001 850.2100 71 - 1A Avian Acute Oral Toxicity

– Mallard ALL 41476402 850.2200 71 - 2a,b Avian Dietary ALL 41476403, 42914001, 00022923, 42914002, 41476401, 00022923 850.2300 Avian Reproduction ALL DATA GAP 850.30 20 141 - 1 Honey bee acute contact LD50 ALL 00018842 , DATA GAP 850.4225 122 - 1(a) Seedling Emergence, Tier II ALL DATA GAP 850.4250 122 - 1(b) Vegetative Vigor, Tier II ALL 45919421, 45919422, 45919416, 44588903 , DATA GAP 850.5400 122 - 2B Aquatic Plant Growth, Tier II ALL DATA GAP **RESIDUE CHEMISTRY** 860.1300 Nature of the Residue - Plants C , I 41137101 41137102 41137103 436326024 92097021 860.1340 Residue Analytical Method - Plants C , I 41142502 41631102 41631104 436326014 92098034 860.1360 Multiresidue Method C , I 41631103

860.1500 Crop Field Trials C , I 40951601 40951602 40951603 40951606 40951607 40951608 40951609 41097001 41097002 41097003 41142501 41142502 41142503 41218101 41218102 41218103 41218104 92098035 92098036 92098037 92098038 92098039 92098040 92098041 92098042 92098043 92098044 92098045 92098046 92098047 92098048 92098049 92098050 92098051 92098052 92098053 92098054 92098055 , 45703705 43703706**Data Requirement Use Patterns**  **Ci tations**  **New Guideline Number Old**  **Guideline Number**  **Description** 43703707 45123901 **TOXICOLOGY** 870.1100 81 - 1 Acute Oral Toxicity - Rat ALL 41277002, 00162331 870.1200 81 - 2 Acute Dermal Toxicity

– Rat ALL 41277003, 00162330, 42442501 870.1300 81 - 3 Acute Inhalation Toxicity

– Rat ALL 41277004, 00162327, 42365605 870.2400 81 - 4 Primary Eye Irritation - Rabbit ALL 44400401 , 41277005, 00162328 870.2500 81 - 5 Primary Skin Irritation

– Rabbit ALL 41277006, 00162329 870.2600 81 - 6 Dermal Sensitization ALL 41277007 870.3200 82 - 2 21 - Day Dermal

– Rabbit/Rat ALL 870.3100 Subchronic Feeding

– Rat/Mouse ALL 41865502, 42117302, 42117301 870.3150 Subchronic Feeding

– Dog ALL 870.3465 82 - 5 90 - Day Inhalation Toxicity

– Rat/Mouse ALL 00162041, 43514802, 00162041 870.3700 83 - 3A Developmental Toxicity

– Rat ALL 41577101, DATA GAP 870.3800 83 - 4 Reproduction and Developmental Effects ALL DATA GAP 870.4100 83 - 1B Chronic Feeding Toxicity Study - Dog ALL 43275801 870.4200 83 - 2 Carcinogenicity

– Mouse/Rat ALL 47067501, 43275802, DATA GAP 870.5100 84 - 2 Bacterial Reverse Mutation Test (Ames Assay) ALL 40305602, 305603 870.5375 84 - 2 Chromosomal Aberration in Chinese Hamster Ovary ALL 40305605 870.5395 84 - 2 Unscheduled DNA Synthesis

– Rat ALL 40305601 , DATA GAP 870.5700 84 - 2 In vitro mammalian gene mutation test ALL 40305604 870.6200a 81 - 8 Acute neurotoxicity screen study in rats, Inhalation Acute Neurotoxicity ALL 43465302, 42977801, 42977802 , DATA GAP 870.7800 85 - 7 Immunotoxicity ALL DATA GAP **ENVIRONMENTAL FATE** 835.12 30 163 - 1 Soil Adsorption ALL 00152844 835.1240 163 - 1 Leaching/Adsorption/Desorption ALL 47010302

835.8100 163 - 3 Field Volatility ALL 47066501, 45 703701, 45703702, 46969601, 47572201, 47131601, 47314301, 45703708, 45703704, 42659901 , 46379201, 47770001, 48011601, 48005901, 47956901, 48115101, 47813901, 47956701, DATA GAP 835.2120 161 - 1 Hydrolysis ALL 41631101, 00158162 835.2240 161 - 2 Photodegradation - Water ALL 41517701**Data Requirement Use Patterns**  **Ci tations**  **New Guideline Number Old**  **Guideline Number**  **Description** 835.2410 161 - 3 Photodegradation - Soil ALL 42978701 835.4100 162 - 1 Aerobic Soil Metabolism ALL 40198502 835.4400 162 - 3 Anaerobic Aquatic Metabolism ALL 43596501 835.6100 164 - 1 Terrestrial Field Dissipation ALL 41514402, 4179860 1 **OCCUPATIONAL AND RESIDENTIAL EXPOSURE** 875.1100 Dermal Exposure

– Outdoor F DATA GAP 875.1200 233 Dermal Exposure

– Indoor X, Y, Z, BB, FF, GG DATA GAP 875.1300 232 Inhalation Exposure

– Outdoor (Applicator) X, Y, Z, BB, FF, GG 42968401, 45123902,

45 703703, 875.1 4 00 234 Inhalation Exposure

– Indoor X, Y, Z, BB, FF, GG DATA GAP 875.1600 235 Application exposure monitoring data reporting X, Y, Z, BB, FF, GG DATA GAP 875.1700 236 Product Use Information X, Y, Z, BB, FF, GG DATA GAP 875.2500 133 - 4 Inhalation Exposure

– Outdoor (Post-Application) X, Y, Z, BB, FF, GG 42968402, 45703703 ,

DATA GAP 875.2700 235 Product Use Information X, Y, Z, BB, FF, GG DATA GAP 875.2800 133 - 1 Description of Human Activity X, Y, Z, BB, FF, GG DATA GAP 875.2900 134 Data Reporting and Calculations X, Y, Z, BB, FF, GG DATA GAP Special NA Fumigant Buffer Zone Posting Signs C, I DATA GAP Special NA Training for Applicators Supervising Fumigations C, I DATA GAP Special NA Training Material for Handlers C, I DATA GAP