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				  December 4, 2002, 3:00 PM - 5:00 PM, EST (20:00-22:00 GMT)Presentation Overview: 
				  This seminar, sponsored by the National Institute for Environmental Health Sciences (NIEHS) and U.S. EPA Office of Emergency and Remedial Response, is the last in a series of three seminars examining current research on PCBs sponsored by EPA and the National Institute of Environmental Health Sciences (NIEHS).  Because of their once-popular commercial uses, improper disposal and environmental persistence, polychlorinated biphenyls (PCBs) are common environmental contaminants found in many designated Superfund sites. This event will highlight the cutting edge research being conducted by NIEHS scientists into the non-cancer endpoints of exposure to PCBs.  Recognition of polychlorinated biphenyls (PCBs) and related compounds as potential human neurodevelopmental toxicants was largely a consequence of two mass poisonings in Japan (1968) and Taiwan (1979).  Dr. Susan Korrick, of Harvard University, will review findings from the population-based epidemiologic studies for which prenatal PCB exposure measures are available.  The particular emphasis will be on findings related to growth and neurocognitive development in infancy and later childhood.  Additionally, Dr. Rita Loch Caruso, of the University of Michigan, will discuss her findings that acute in vitro exposures to commercial PCB mixtures and microbially dechlorinated commercial PCB mixtures increase the frequency of spontaneous contractions of uteri from pregnant rats.  Increased uterine stimulation was observed with PCB mixtures containing increased abundance of lesser-chlorinated, ortho-substituted congeners. By showing that PCBs stimulate uterine contraction in vitro, these studies provide a biologically plausible mechanism by which PCB exposures could decrease gestation length.Presenters: 
				  **Instructors:**
				  
				  
				  Susan Korrick, M.D., Harvard School of Public Health (susan.korrick@channing.harvard.edu)
Rita Loch Caruso, University of Michigan (rlc@umich.edu)**Moderators:**
				  
				  Larry Whitson, National Institutes of Health, National Institute of Environmental Health Sciences (whitson@niehs.nih.gov)
				  Carlos Pachon, U.S. EPA, Technology Innovation Office (pachon.carlos@epa.gov)Press the "Go to Seminar" button to view the
					 seminar. Please be at this location at the beginning of the conference
					 call.Download Seminar For Future Reference 
				  The seminar is available for download in
					 both Microsoft PowerPoint and Adobe
					 Acrobat formats.After the seminar is complete, please
					 view:Links to Additional
							 Resources0Disclaimer
	Produced by the U.S. EPA, Technology Innovation and Field Services DivisionQuestions about our Internet Seminars? | Technical problems?Rehabilitation Act Notice for Reasonable Accommodation, Webinar Recording, and Content Disclaimer | NIEHS/EPA PCBs - Health EffectsSponsored by: National Institutes of Health, National Institute of Environmental Health Sciences & U.S. EPA, Office of Emergency and Remedial Response | Original Time/Date of Presentation: | December 4, 2002, 3:00 PM - 5:00 PM, EST (20:00-22:00 GMT) |  | Presentation Overview: | This seminar, sponsored by the National Institute for Environmental Health Sciences (NIEHS) and U.S. EPA Office of Emergency and Remedial Response, is the last in a series of three seminars examining current research on PCBs sponsored by EPA and the National Institute of Environmental Health Sciences (NIEHS).  Because of their once-popular commercial uses, improper disposal and environmental persistence, polychlorinated biphenyls (PCBs) are common environmental contaminants found in many designated Superfund sites. This event will highlight the cutting edge research being conducted by NIEHS scientists into the non-cancer endpoints of exposure to PCBs.  Recognition of polychlorinated biphenyls (PCBs) and related compounds as potential human neurodevelopmental toxicants was largely a consequence of two mass poisonings in Japan (1968) and Taiwan (1979).  Dr. Susan Korrick, of Harvard University, will review findings from the population-based epidemiologic studies for which prenatal PCB exposure measures are available.  The particular emphasis will be on findings related to growth and neurocognitive development in infancy and later childhood.  Additionally, Dr. Rita Loch Caruso, of the University of Michigan, will discuss her findings that acute in vitro exposures to commercial PCB mixtures and microbially dechlorinated commercial PCB mixtures increase the frequency of spontaneous contractions of uteri from pregnant rats.  Increased uterine stimulation was observed with PCB mixtures containing increased abundance of lesser-chlorinated, ortho-substituted congeners. By showing that PCBs stimulate uterine contraction in vitro, these studies provide a biologically plausible mechanism by which PCB exposures could decrease gestation length. |  | Presenters: | **Instructors:**
				  
				  
				  Susan Korrick, M.D., Harvard School of Public Health (susan.korrick@channing.harvard.edu)
Rita Loch Caruso, University of Michigan (rlc@umich.edu)**Moderators:**
				  
				  Larry Whitson, National Institutes of Health, National Institute of Environmental Health Sciences (whitson@niehs.nih.gov)
				  Carlos Pachon, U.S. EPA, Technology Innovation Office (pachon.carlos@epa.gov) |  |  | Press the "Go to Seminar" button to view the
					 seminar. Please be at this location at the beginning of the conference
					 call. |  | Download Seminar For Future Reference | The seminar is available for download in
					 both Microsoft PowerPoint and Adobe
					 Acrobat formats. |  | After the seminar is complete, please
					 view: | Links to Additional
							 Resources | Links to Additional
							 Resources | 
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|NIEHS/EPA PCBs - Health EffectsSponsored by: National Institutes of Health, National Institute of Environmental Health Sciences & U.S. EPA, Office of Emergency and Remedial Response
|Original Time/Date of Presentation:                                                                                                                                                   | December 4, 2002, 3:00 PM - 5:00 PM, EST (20:00-22:00 GMT)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
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|Presentation Overview:                                                                                                                                                                | This seminar, sponsored by the National Institute for Environmental Health Sciences (NIEHS) and U.S. EPA Office of Emergency and Remedial Response, is the last in a series of three seminars examining current research on PCBs sponsored by EPA and the National Institute of Environmental Health Sciences (NIEHS).  Because of their once-popular commercial uses, improper disposal and environmental persistence, polychlorinated biphenyls (PCBs) are common environmental contaminants found in many designated Superfund sites. This event will highlight the cutting edge research being conducted by NIEHS scientists into the non-cancer endpoints of exposure to PCBs.  Recognition of polychlorinated biphenyls (PCBs) and related compounds as potential human neurodevelopmental toxicants was largely a consequence of two mass poisonings in Japan (1968) and Taiwan (1979).  Dr. Susan Korrick, of Harvard University, will review findings from the population-based epidemiologic studies for which prenatal PCB exposure measures are available.  The particular emphasis will be on findings related to growth and neurocognitive development in infancy and later childhood.  Additionally, Dr. Rita Loch Caruso, of the University of Michigan, will discuss her findings that acute in vitro exposures to commercial PCB mixtures and microbially dechlorinated commercial PCB mixtures increase the frequency of spontaneous contractions of uteri from pregnant rats.  Increased uterine stimulation was observed with PCB mixtures containing increased abundance of lesser-chlorinated, ortho-substituted congeners. By showing that PCBs stimulate uterine contraction in vitro, these studies provide a biologically plausible mechanism by which PCB exposures could decrease gestation length.
|                                                                                                                                                                                     
|Presenters:                                                                                                                                                                           | **Instructors:**
				  
				  
				  Susan Korrick, M.D., Harvard School of Public Health (susan.korrick@channing.harvard.edu)
Rita Loch Caruso, University of Michigan (rlc@umich.edu)**Moderators:**
				  
				  Larry Whitson, National Institutes of Health, National Institute of Environmental Health Sciences (whitson@niehs.nih.gov)
				  Carlos Pachon, U.S. EPA, Technology Innovation Office (pachon.carlos@epa.gov)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|                                                                                                                                                                                     
|                                                                                                                                                                                      | Press the "Go to Seminar" button to view the
					 seminar. Please be at this location at the beginning of the conference
					 call.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
|                                                                                                                                                                                     
|Download Seminar For Future Reference                                                                                                                                                 | The seminar is available for download in
					 both Microsoft PowerPoint and Adobe
					 Acrobat formats.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|                                                                                                                                                                                     
|After the seminar is complete, please
					 view:                                                                                                                                   
|Links to Additional
							 Resources                                                                                                                                                | Links to Additional
							 Resources                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
|Links to Additional
							 Resources                                                                                                                                               
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