UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WAS HINGTON , D .C

. 2 0 460 

## JA N 1 2 2 011

OFFICE OF C HEMICAL SAFETY A ND POLLUTIO N PREVE NTION 

### MEMORAND UM

J ihad A lsadek , Eco nomist Sc ience Inf ormation a nd An alysis B ranch BEA D C hemical Pr ofile f or R egistration Rev iew: Fludi oxo nil (PC co de : 07 1503) T a ra C han dgoy al, Pl ant Pat hologi s t 

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TUR U: Mic helle Ran vill e , Eco nomi s t
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### In f) E c o nom i c A na lysis B ranch 

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### Bio logical and D ivi si on (75 03P) ArnetJo nes,C hief 

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# - B iological Analy s i s**"""-** D iann S im s, C hi e f 

# /n v-:J Scie nce Inf o rmation a nd A naly s is B ranch T imo thy Ki ely, C hie f

# t'1-V"\.~ Econ o mic A naly s is B ranch""J 

# j Bi ological and Econo mic A naly s is D ivisi o 75 03P) 

### TO: C a ris sa C ry an , C he mica l R eview Manager R isk Man agement and Impl em entat ion B ranch I Pe sti cide Re -evaluation Di vi si on (7508P)



### P EER REVI EW DA TE : DE CEMBER 15, 2010 I NTRODUCTIO N T he purp ose o f thi s d o cume nt is t o co nvey u sa ge i nfo rmatio n and a br oad o verview o f the pe st man agement role s o f p e sti cides that are b e ginnin g reg istration re vi ew . The intended a udience f or thi s d ocument i s th e O PP reg i strat ion r eview team and th e g eneral p ub lic. Thi s d ocum ent b uilds u po n th e d ata al ready pro vided in the " Usage and Label Us e Da ta P a cka g es" that ar e a l so
I

### prov ided to Re gi stra t io n Re view team s by the Bi ological an d Econo mic Analy sis Divi sion 

### ( BEAD)

. B ased o n mod e s of acti on of fu n gicide s F ung icide R e sis tance A c tion Co mmittee (F RAC) has cl as sified fludi oxonil int o group 1 2 ( FRA C , 2 01 0). Th i s i s a non-sys temic f ung ic ide that i nhib it s m ycelial growth o f f ungi po ssi bly b y inh ibiti on o f tran sport- a ss ociated ph o sp h ory lation o f g l ucose . T hi s fung icide i s m ain ly u s ed for s ee d treatm en t and f o li a r applic ati o n a ga in s t m any plant pathogenic fu ng i (s uc h a s Fusa rium, Rhiz o ct onia , T elle tia, Helmlnto s porium
. B o tryt is . M

ontltnia

. a nd A lternaria ) , 

### U SE S ITES Ag ricultural Us e S ite s Fludio xonil i s u s ed o n v ario us be rry crop s (s uc h as s traw berry, cane berry, bl ueberry, b la c kberry ), citru s (l emon , l ime , o range s, ta ngelo , ma ndarin s, tan g erine ), pom e f ruits ( app les, pe ars) , s to ne f ruit s ( cherry, ne cta rine , pe a ch, p l um s, prun e s ) , p om e granate s , l i tc h i, herbs and s p i c es (anise , ba sil, catnip , cinnamon , c ilantro, fe nnel, dill , ging e r , nutme g , bl ack pepper , r o sem ar y) , c ucurbi ts (m elon , c antalou pe s, h o neydew, mu sk melon , pumpkin , c ucumbe r , s q ua s h , gourd s), E gg p lant, tomat o , le af y v egetable s ( c e lery, lettu ce, s p in ac h), br a ss ica le afy vegetab le s (brocco li , cabbage , c a ul i fl o wer, ka l e , mu st ard gre en), tub e rous and c o nn veget ables ( potato, radi sh, y a m s) , bu lb ve ge table s (o ni o ns ), be an s ( s o ybean , b lack

- e yed , c h ick pea, ki dney , pi nto, navy , lim a, s nap , g ree n , s tri n g), corn , ornam enta l s ( begonia , c a la dium , cam at ion, dahl ias, dai s ie s , pan sies, po in settia, pet un ia, sa l via, s un flo we r, tu lip, z in n ia )

. N on -A gricu lt ural Use S ites T arpauli ns, ca rpets, dr ape s , wood s tru ctures, i rr i g at io n s upp ly sys t e ms, irr i g ati on sys te ms , irrigat io n s upp l y s y s te ms ( water tr eatment ) , rec reational ar eas ( foliar tre a tment) , p ark s ( f oli ar tre atment ), athletic fi e ld s (fo liar tre atment ) , pepper pro ce ss in g p lant s (i n door edibl e ) , c o mmercia l/in stit utiona l/industria l areas (o utdoor), a dhe s ive s, c au l kin g c o mp ound s, adh esives ( s ynthetic) , wa ll board jo int co mpound , l ate x ca u l ks, s ealant s ( ac ry l ic / p v a) , s ea l ants , co ating s ( pre s erv at ive inco rporati o n ), c oatings, p aper /p aperboard, p la s tic s (p vc), pl a sti c pr odu cts ( m an u fac turi ng ad di ti ve) , s h owe r c u rtain s, pol y urethane , rubbe r, e m ulsions ( u n s pe c ifi ed), a ir filte r m at er ia l s, tex tiles, fiber s , corda ge (p reservati ve/a d ditiv e), a wn ing s, c anvas, c ordage , f abrics , tent s, text ile s, te xtile s ( fibe r filli ng ), boa t c over s, p aints ( o i l), sta in ( pre s e rvati ve in corporation) , p aints { water- b as ed ), carpets ( hosp i tal, c omme rcia l , h o u se hold), fil te rs ( air /a ir c o ndi tioner /fu rnace/a ir d ucts), aerial appl icatio n , low v o lume a ppl i cation (a ll o r unspeci fied ), har d nonporo u s s ur face, ce ili ngs, wood s u rf aces . 

### C OM MON FORM ULATIO NS AND A PP LICATI ON M E TH ODS F lud ioxoni l i s f o rmulated a s emu l sifiable co ncentrate , water di spers ible granul e s , ready to u se s o lution a nd pre s surized liqui d

.



### 2USAGE Ag ricu ltura l F l u dioxo ni l wa s registered in 1 996

. B ased o n p rivate m arket pes ticide u sage d at a , th e annu al t otal ag ricultural us age a veraged 13, 000 po unds ac tive in gredient (A. I.) f or ap proximately 5 m illi on ac res (G fK K ynetec, 1 9 98-2008)

. Th e lar gest u ses of fl u dioxo ni l, in term s o f pound s A. I., are mai n ly o n soy bean s, s trawberrie s, and can eberri es . From 1998 -2008, th e l arge s t m arket s in term s of t o tal pou nd s o f act ive ingredient ap p l ied we re : 

### s oybeans (4 2 % ), 

### strawberrie s ( 37 % ), 

### and ca neberrie s ( 10 %). I n term s of th e acre s treated ; soybean s ( 82%) , co tton ( 17 %), and s trawberrie s ( 1 %)

. ( GIK Kyn etec, 1998 -2008)

. Fo r the same time period, the s tates with the m ost agricultural u sage in term s of Pound s Al a pplied were: Iowa ( 1 1%) , Minne sota and Arkansas 8 % ea ch)

. (GIK Kyne tec , 1 9 98

- 2008 )

. No n -Agricu ltural L imited n on-agricultur al data ava i lab le t o BEAD s h ow tha t u s age o n go lf cou r ses t o be l e ss t han 500 p ound s a .i

. in 1 9 9 9 t o a lmos t 2,00 0 Ib s a .i

. in 2 006. I n 1 999 fludiox on iI' s u s e on nur sery / greenhouse seg ment wa s al so l e s s than 5 00 lb s. a .i

. and re ached a bout 5,00 0 I b s . a .i

. in 2 006 (K line Stud ies , In c ., 1 999-2006)

. USE T RENDS F igures 1-3 provide s historical usa ge data fr om 19 98 -2 008 for soy be ans , strawberrie s , and caneberrie s. Flu dioxonil u sage was not s urveyed before 20 06

. Thi s i s due t o da ta limi tation o r min imal use wa s re corded befo re 2006

. The data have not been ana lyzed i n detail and are provided fo r p relimi nary s copi n g p urpo ses o nl y . Soybeans 30, 000



# .. • -e c 

# , 0 

# .. 0 1999 2001 2002 2003 2004 200 5 2006 2007 2006 Years Figu re 1. P ounds of F lud ioxonil App lied 10 Soyb eans (20 06

- 2008) Sou rce : O fK K ynetec , 1998-2008 Soybean s we re n ot s urveyed be fore 2006

.



### 3

### Strawb erries
1 4 ,000

-' 

### ..;. 0 ." e 0 0- 0 

# 0 0 1999 2001 2002 2003 2004 2005 2006 2007 2008 Yea rs F igu re 2

. P ounds of Fl udioxooil App lied t o Stra wberries (1998- 2008) So urc e: GfK Ky netec , 1 998-2008


### Caneb erri es 6,000

-' 

### ..;. 0 ." e 0 0- 0 1 999 2001 2002 2003 2004 2005 2006 2007 200 8 Y

ears Fi gure 3

. P o unds of Fludioxonil Applie d to Caneberries (1998 -2008) S our ce: GfK Ky netec , 1 998-2008 

### BIOLOGICAL ASPECTS RELEVANT T O FL UDIOXON IL Resistance in plant pa thogenic fu ngi agai nst flud ioxonil is fo un d s pora d ica ll y ( FRAC, 2010). The ri sk o f fun gi develop ing r esistance agai n st th is fu ngicide i s low to medi um and resistance m anagement i s recomm ended (FRAC, 2 010). BEAD i s n ot aware of any p lant hea lth bene fits clai m s o r pu blic hea lth i s sue s f or thi s fun gicide

.

4HI STORY OF B EAD ASSES SMENTS FOR F L UDIOXO NIL B EAD has co nducted m ore than a d ozen Section 18 ana ly ses for fl udiox o nil. T able 1 di s play s pes t and s ite i nformat ion f o r the Sectio n 1 8 emerg e ncy exe mption req ue s ts f o r fludioxo nil for whic h B EAD conducted an analysis and the rec o mmendati on of that ana ly sis

. Tab le I

. B EAD A naly ses of Sec tion 1 8 Emergency Exe mpti o n Req ue st s for F ludioxonil

C ode 9 7 WA I4 97 MN 17 97N D16 9 9 0R47 99WA 31 990 R37 99F L02 99SC 06 00SC02 0 l CA I3 0l CA28 0 20 R25 03TX09 04 CAII 0 7FL05 10H IOI S ite P otatoe s 

### P

otatoes Po tatoe s Peac he s C ranberries C ranberrie s St rawberr i e s S t raw berrie s St rawbe rrie s S tone Fruit s P o megranate s Pe ache s Leafy V egetab le s

P omearanares Sta r Fruit Pin eapp le s Pes. tcommon name) S i lver S curf Sil ve r Sc urf S ilve r Scurf Brow n R ot

Botrvti s Botrvti s G ray M old Gr ay M old Gr av M old Brown R ot I G ravMo ld G ray M old Bro wn R o t Po wd ery Mildew G ray Mol d

Fruit R ot Cladorsporium & P enicillium M o ld BEAD recommendation Uree nt a nd n o n- ro utine ; SE L like lv Ur eent a nd n o n-r outine ; SE L like lv U rgent and n o n -routine ; SE L lik ely U rgent and n on- routine ; SE L lik el v Urge nt and n on-rou tine ; SE L likel y U r zent a nd n on- r o utine ; SE L lik e ly No t u reen t or n on-rout ine ; SEL n o t Iikelv M ore dat a n eeded ; SE L n o t likel y n/. U rge n t a nd n on- routi n e ; SEL li ke ly U rae n t and n on-ro utine ; SEL l ik ely U rge n t a nd n on - routi ne; SEL like ly U rg en t an d n o n-r ou tine ; S EL pos si ble; mo re data need ed U r z ent a nd n on - ro u tine ; S EL lik elv U r g en t a nd n on - ro ut i ne ' SE L l ike ly U r ge n t a nd n o n- ro u t i n e ; SEL lik e l y No te : Th e c ode 10 t he fi rst c o lu mn Id entifies t he ye ar o f t he req uest 10 the fi rst two ch arac te rs and th e reque s ting s tate i n t h e s eco nd tw o character s. DA TA N EEDS REL EVA NT TO BEAD'S FU T URE WORK O N FL UDIO XO NIL Data o n po stharve st a gricu ltur a l u se and u sage o f fludi oxoniL REFERENCES E PA Sec tion 1 8 D atabase

. Availa ble at hnp : l lcfpubl .epa.gov /oppret i' section 18 /search .cfm FRA C. 2 0 10

. Fung icide Resis tance A ction Com mittee Code L i s t
. hnp: //\\ "ww .frac.info /fra c /publicatio nlanhan giFRA C Code Li st 2 010 .pdf GtK Ky n etec
. 1 99 8-2008 Kl ine S tudi e s, In c . 1999 -2006



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