Support Documents for 

Significant New Use Rule (SNUR) on 

Premanufacture Notice (PMN) 

P-09-373 

EPA Docket EPA-HQ-OPPT-2010-1075 

 

EPA SANITIZED Page 1 of 37
Index

A-001 Structure Activity Team (SAT) Report for 

PMN P-09-373 

A-002 Initial Review Engineering Report for 

PMN P-09-373 

A-003 Initial Review Exposure Report for 

PMN P-09-373 

EPA SANITIZED Page 2 of 37
A-001 

Structure Activity Team (SAT) Report 

 for PMN P-09-373 

 

EPA SANITIZED Page 3 of 37
SAT Report

PMN Number: P-09-0373

SAT Date: 5/29/2009

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 2

 Persistence Bioaccum Toxicity Comments

 1 1 1 Anion

 3 1 2 Mn

Exposure Based Review:

Health:

Ecotox: No

Routes of exposure: Health: Inhalation, drinking water

Ecotox: All releases to water

Fate: ; Anion negl; Cation slow

Keywords:

 Keywords: THYROID; KIDNEY; BLOOD; LIVER; IRR; NEURO; 

UNCERT-IMMUNO; MUTA; UNCERT-ONCO; AQUATOX

Summary of Assessment:

 Fate:

Fate Summary: P-09-0373

FATE: 

Solid 

S > 10 g/L at 25 EC (ICB)

VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = Anion 90-99 via biodeg; Cation 35.5 via sorption

Time for complete ultimate aerobic biodeg = U

Sorption to soils/sediments = Anion low; Cation moderate

PBT Potential: Anion P1B1; Mn: P3B1

EPA SANITIZED Page 4 of 37
*CEB FATE: Migration to ground water = Anion negl; Cation slow

 Health:

 Health Summary: Not absorbed from the skin, absorbed from the lung 

(pchem), absorbed from the GI tract (analog). There are multiple studies available for the sulfate 

material (mostly the monohydrate) from NTP and a TSCA Section 8e submission. This 

chemical is considered to be a better analog than the variety of salts of thiosulfate included in the

PMN submission. In a 90-day inhalation study in rats signs of nasal irritation were 

noted at 1.53 mg Mn/m3 with a NOEL of 0.31 mg Mn/m3. Red blood cell depression was seen 

in a 13-week dietary study in rats at 6,250 ppm and greater in the diet with a NOEL of 3,130 

ppm (NTP TR-428). A lesser degree of toxicity was noted in the 13-week dietary study in mice 

with a NOEL of 12,500 ppm and lower leukocyte counts at 25,000 ppm and greater. Manganese 

(II) sulfate monohydrate was not mutagenic in Salmonella typhimurium with and without

activation and did not induce sex-linked recessive lethal mutations in germ cells of Drosophila. 

The analog was positive for sister chromatid exchange and chromosomal aberrations in Chinese

hamster ovary cells. Mn sulfate is positive in yeast and other Mn compounds are positive for 

mutagenicity. There is uncertain concern for oncogenicity by analogy to Mn (II) sulfate 

monohydrate which showed no evidence of carcinogenic activity in male and female rats at

doses up to 15,000 ppm in the diet and equivocal evidence in male and female mice based on

marginally increased incidence of thyroid gland follicular cell adenoma and a significant

increase in follicular cell hyperplasia. There was decreased survival in males at the top dose 

(15,000 ppm) caused predominantly by advanced renal disease. Potential liver effects were also 

noted. Additional concerns for Mn are neurotoxicity and possible immunotoxicity.

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 9.4

daphnid 48-h LC50 64

green algal 96-h EC50 <60

fish _ chronic value 4.0

daphnid _ chronic value 12

algal _ chronic value <15

Sewage Sludge 3-h EC50 _

Sewage Sludge Chronic Value

Ecotox Values Comments: Predictions are based on SAR-nearest analog analysis for soluble 

salts of Mn with MW adjustment; SAR chemical class = Mn.thiosulfuric acid; MW167 with 

33wt% Mn (MW55); solid with mp unknown (P); S > 180 g/L at 20 C, pH 7 (P); pH7; 

effective concentrations based on 100% active ingredients and mean measured concentrations of 

total Mn; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

EPA SANITIZED Page 5 of 37
Concentration of Concern 

(ppb)

400

SARs Mn salts

SAR Class Mn salt

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916

EPA SANITIZED Page 6 of 37
A-002 

Initial Review Engineering Report 

 for PMN P-09-373 

 

EPA SANITIZED Page 7 of 37
INITIAL REVIEW ENGINEERING REPORT

P-09-0373

Focus Ready Draft 6/4/2009

ENGINEER: Prothero \ AH

PV (kg/yr): 

Revision Notes/Assessment Overview:

SUBMITTER: Tessenderlo Kerley, Inc. (submitter)

USE: Micronutrient manganese source for selected agricultural crops. 

OTHER USES:

MSDS: Yes LABEL: Yes

Gen Eqpt: Neoprene rubber gloves and apron. Chemical goggles and full face shield. Adequate exhaust ventilation 

to prevent inhalation of product vapors.

Respirator: None generally required. If conditions exist where mist may be generated, a NIOSH/MSHA approved 

mist respirator should be worn.

Health Effects: Contact may cause eye irritation. Repeated/prolonged skin contact may cause irritation. Ingestion 

may irritate gastrointestinal tract. Heating may cause sulfur dioxide gas to evolve.

TLV/PEL: - none established

CRSS: (12:00:00 AM):

Chemical Name: Thiosulfuric acid (H2S2O3), manganese(2+) salt (1:1)

S-H2O: 180 g/L @ 

VP: 1.0E-6 torr @ 

MW: 167 0.0%<500 0.0%<1000

Physical State and Misc CRSS Info:

Neat: Solid Mfg: Solution: 18% PMN substance in water

Proc/Form: Solution: 6% PMN substance in water End Use: Solid: deposited in soil. Submitted data: The 

MSDS and Physical/Chemicals Property Worksheet are for the 18% solution of the PMN substance in water. Pale 

pink liquid; density (18% solution in water) = 1.19 g/L; pH (18% solution in water) = 5.68. Estimated Data: VP 

<0.000001 torr (Salt); S-H2O > 180 g/L (Concentration of manufactured substance).

Consumer Use: No

SAT (concerns): (5/29/2009):

Migration to groundwater: Anion negligible; Cation slow

PBT rating: P3 B1 T2 PBT Potential: Anion P1B1T1; Mn P3B1T2

Health: 1-2, Drinking Water, Inhalation

Eco: 2, Water (All releases to water with a CC = 400 ppb)

OCCUPATIONAL EXPOSURE RATING: 2C

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

EPA SANITIZED Page 8 of 37
POLLUTION PREVENTION CONSIDERATIONS:

None

P2 REC:

EXPOSURE-BASED REVIEW: No (0 criteria met)

EPA SANITIZED Page 9 of 37
P-09-0373

Use: 

Number of Sites/Location: 1 

 

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources 

to the same medium. 

Water or Landfill

High End: 6.0E-2 kg/site-day over 10 day/yr from 20 sites or 1.2E+1 kg/yr

to: uncertain

from: 

basis: 

Water or Landfill

Output 2: 9.5E+0 kg/site-day over 10 day/yr from 20 sites or 1.9E+3 kg/yr

to: 

from: 

basis:

RELEASE TOTAL

1.9E+3 kg/yr - all sites

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 60

Basis:

.

Inhalation:

Exposure to Mist 

Upper Bound: 9.0E+0 mg/day over 10 days/yr

Number of workers (all sites) with Inhalation exposure: 60

Basis:

EPA SANITIZED Page 10 of 37
INHALATION MONITORING DATA REVIEW

1) Uncertainty (estimate based on model, regulatory limit, or data not specific to industry): Yes

2) (a) Exposure level > 1 mg/day? Yes

 (b) Hazard Rating for health of 2 or greater? No

Inhalation Monitoring Data Desired? No

Dermal:

Exposure to Liquid 

High End: 3.2E+2 mg/day over 10 days/yr

Number of workers (all sites) with Dermal exposure: 60

Basis: 

EPA SANITIZED Page 11 of 37
P-09-0373

Manufacturing

Number of Sites/Location: 1

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources 

to the same medium. 

Water or Landfill

Conservative: 4.4E+0 kg/site-day over 9 day/yr from 1 sites or 4.0E+1 kg/yr

to: uncertain

from: 

basis:

RELEASE TOTAL

4.0E+1 kg/yr - all sites

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 3

Basis:

Dermal:

Exposure to Liquid 

High End: 3.2E+2 mg/day over 9 days/yr

Number of workers (all sites) with Dermal exposure: 3

Basis: 

EPA SANITIZED Page 12 of 37
P-09-0373

Distribution

Number of Sites/Location: 1 

 

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources 

to the same medium. 

Water or Landfill

Conservative: 1.3E+0 kg/site-day over 10 day/yr from 3 sites or 4.0E+1 kg/yr

to: uncertain

from:

basis: 

RELEASE TOTAL

4.0E+1 kg/yr - all sites

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 9

Basis:

Dermal:

Exposure to Liquid 

High End: 3.2E+2 mg/day over 10 days/yr

Number of workers (all sites) with Dermal exposure: 9

Basis: 

EPA SANITIZED Page 13 of 37
INITIAL REVIEW ENGINEERING REPORT 

PMN: 09-0373

Standard Review Draft 7/7/2009

ENGINEER: Prothero \ AH

PV (kg/yr): 

SUBMITTER: Tessenderlo Kerley, Inc.

USE: Micronutrient manganese source for selected agricultural

crops. 

OTHER USES: 

MSDS: Yes Label: Yes

Gen Eqpt: Neoprene rubber gloves and apron. Chemical goggles and

full face shield. Adequate exhaust ventilation to prevent

inhalation of product vapors.

Respirator: None generally required. If conditions exist where

mist may be generated, a NIOSH/MSHA approved mist respirator

should be worn.

Health Effects: Contact may cause eye irritation.

Repeated/prolonged skin contact may cause irritation. Ingestion

may irritate gastrointestinal tract. Heating may cause sulfur

dioxide gas to evolve.

TLV/PEL:

none established

CRSS :

Chemical Name: Thiosulfuric acid (H2S2O3), manganese(2+) salt (1:

1)

S-H20: 180 g/L @

VP: 1.0E-6 torr @

MW: 167.00 %<500 %<1000

Physical State and Misc CRSS Info:

Neat: Solid Mfg: Solution: 18% PMN substance in water Proc/Form:

Solution: 6% PMN substance in water End Use: Solid: deposited in

soil. Submitted data: The MSDS and Physical/Chemicals Property

Worksheet are for the 18% solution of the PMN substance in water.

 Pale pink liquid; density (18% solution in water) = 1.19 g/L;

pH (18% solution in water) = 5.68. Estimated Data: VP <0.000001

torr (Salt); S-H2O > 180 g/L (Concentration of manufactured

substance).

Consumer Use: No

SAT (concerns) (05/29/2009):

Related Cases and Related Cases and Misc SAT Info:

EPA SANITIZED Page 14 of 37
Migration to groundwater: Anion negligible; Cation slow

PBT rating: P3B1T2 PBT Potential: Anion P1B1T1; Mn P3B1T2

Health: 1-2 Drinking Water, Inhalation

Eco: 2 Water (All releases to water with a CC = 400 ppb)

OCCUPATIONAL EXPOSURE RATING: 2B

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

POLLUTION PREVENTION CONSIDERATIONS:

None

EXPOSURE-BASED REVIEW: No

EPA SANITIZED Page 15 of 37
INITIAL REVIEW ENGINEERING REPORT 

PMN: 09-0373

Manufacturing

Number of Sites/ Location: 1

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 0

Basis:

Inhalation:

Dermal:

EPA SANITIZED Page 16 of 37
INITIAL REVIEW ENGINEERING REPORT 

PMN: 09-0373

Number of Sites/ Location: 3

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 0

Basis:

Inhalation:

Dermal:

EPA SANITIZED Page 17 of 37
INITIAL REVIEW ENGINEERING REPORT 

PMN: 09-0373

Use: 

Number of Sites/ Location: 20

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 20

Basis:

Inhalation:

Exposure to Mist (non-volatile) (Class I)

What-If: 2.8E+0 mg/day over 10 days/yr

Number of workers (all sites) with inhalation exposure: 20

Basis: 

EPA SANITIZED Page 18 of 37
NOTE: The respirator class is: I. Particulate (including solid

or liquid droplets).

INHALATION MONITORING DATA REVIEW

1) Uncertainty (estimate based on model, regulatory limit,

 or data not specific to industry): Yes

2)a) Exposure level > 1 mg/day? Yes

 OR

 b) Hazard Rating for health of 2 or greater? 1-2 No

Inhalation Monitoring Data Desired? Yes (both criteria met)

Dermal:

EPA SANITIZED Page 19 of 37
A-003 

Initial Review Exposure Report 

for PMN P-09-373 

 

EPA SANITIZED Page 22 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT (IRExR) 

 Chemical ID: P090373 Reviewer: Kwon 

 

Results Table: Dose, Concentration, and Days Exceeded Results Summary 

Exposure Scenario1 Water Landfill Stack Air Fugitive Air 

Drinking Water Fish Ingestion 

ADR LADD ADR LADD 

7Q104 

CC=400 

PDM 

Days 

Exceeded

LADD ADR LADD ADR LADD 

Release activity(ies)2; 

exposure 

calculation(s)3

mg/kg/day mg/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day mg/kg/day mg/kg/day mg/kg/day mg/kg/day 

ANION 

max ADR, max 

Acute Eco, max 

LADD 

2.63E-03 1.12E-06 --- --- 54.53 --- --- --- --- --- --- 

max ADR, max Acute 

Eco, max LADD 

5.47E-04 4.69E-07 --- --- 11.21 --- --- --- --- --- --- 

max ADR, max 

Acute Eco, max 

LADD 

2.76E-02 1.23E-05 --- --- 604.72 --- --- --- --- --- --- 

CATION 

max ADR, max 

Acute Eco, max 

LADD 

8.33E-03 3.56E-06 --- --- 172.87 --- --- --- --- --- --- 

max ADR, max Acute 

Eco, max LADD 

1.74E-03 1.50E-06 --- --- 35.74 --- --- --- --- --- --- 

 max ADR, max 

Acute Eco, max 

LADD 

8.75E-02 3.91E-05 --- --- 1916.75 --- 6.55E-05 --- --- --- --- 

1

 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation. 2 Release activities are from engineering report's Manufacturing (Mfg), Processing (Proc) and Use release activity 

labels. 

Multiple release activities are combined in one exposure scenario if their releases occur at same location. 3

 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and Probabilistic 

Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure scenario. 

CC is the aquatic concentration of concern. 

4

 This column displays concentration values for the 7Q10 streamflow, which is defined as the average streamflow of 

the 7 consecutive days of lowest flow within a 10 year period. 

Remarks: 

Fate test recommendations?: 

EPA SANITIZED Page 23 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090373anion Assessor: Kwon 

ENVIRONMENTAL RELEASES 

 Scenario#:1 Number of Release Sites: 

 Release Activity: max ADR, max Acute Eco, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

EPA SANITIZED Page 24 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090373anion 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 1 Number of Sites: RELEASE ACTIVITY max 

ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: 

SIC-CODE (S): EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 0.10 0.32 0.47 0.57 

ALL 10 5.83 31.45 54.53 65.12 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 2.01E-08 1.12E-06 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 1.03E-06 5.75E-05 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 2.64E-05 2.63E-03 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

EPA SANITIZED Page 25 of 37
6/3/2009 Page of 

 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090373anion Assessor: 

ENVIRONMENTAL RELEASES 

 Scenario#:2 Number of Release Sites 

 Release Activity: max ADr, max Acute Eco, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

EPA SANITIZED Page 26 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090373anion 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 2 Number of Sites: RELEASE ACTIVITY

max ADr, max Acute Eco, 

max LADD 

SIC-CODE DESCRIPTION: POTW (Indust., includes POTWs which receive ind. disch.) 

SIC-CODE (S): 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 288.00 123.84 78.18 66.05 0.30 0.70 1.11 1.32 

ALL 10 39.60 13.29 7.76 7.57 2.20 6.55 11.21 11.49 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 6.46E-08 4.69E-07 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 3.31E-06 2.41E-05 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 5.87E-05 5.47E-04 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

EPA SANITIZED Page 27 of 37
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 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090373anion Assessor: 

ENVIRONMENTAL RELEASES 

 Scenario#:3 Number of Release Sites: 

 Release Activity: : max ADR, max Acute Eco, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

EPA SANITIZED Page 28 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090373anion 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 3 Number of Sites RELEASE ACTIVITY max 

ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: POTW's (All facilities) 

SIC-CODE (S): 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 125.56 44.02 26.80 22.53 5.11 14.56 23.92 28.45 

ALL 10 11.11 1.94 1.06 0.96 57.70 330.41 604.72 667.71 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 1.09E-06 1.23E-05 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 5.59E-05 6.32E-04 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 1.22E-03 2.76E-02 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

EPA SANITIZED Page 29 of 37
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 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090373cation Assessor: Kwon 

ENVIRONMENTAL RELEASES 

 Scenario#:1 Number of Release Sites: 

 Release Activity: max ADR, max Acute Eco, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

EPA SANITIZED Page 30 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090373cation 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 1 Number of Sites RELEASE ACTIVITY max 

ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: 

SIC-CODE (S) EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 0.33 1.00 1.47 1.82 

ALL 10 18.49 99.71 172.87 206.46 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 6.37E-08 3.56E-06 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 3.26E-06 1.82E-04 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 8.35E-05 8.33E-03 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

EPA SANITIZED Page 31 of 37
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 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090373cation Assessor: 

ENVIRONMENTAL RELEASES 

 Scenario#:2 Number of Release Sites: 

 Release Activity: max ADR, max Acute Eco, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

EPA SANITIZED Page 32 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090373cation 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 2 Number of Sites: RELEASE ACTIVITY

max ADR, max Acute Eco, 

max LADD 

SIC-CODE DESCRIPTION: POTW (Indust., includes POTWs which receive ind. disch.) 

SIC-CODE (S): 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 0.00 0.00 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 288.00 123.84 78.18 66.05 0.96 2.24 3.55 4.20 

ALL 10 39.60 13.29 7.76 7.57 7.00 20.87 35.74 36.64 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 2.06E-07 1.50E-06 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 1.06E-05 7.68E-05 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 1.87E-04 1.74E-03 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

EPA SANITIZED Page 33 of 37
6/3/2009 Page of 

 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090373cation Assessor: 

ENVIRONMENTAL RELEASES 

 Scenario#:3 Number of Release Sites: 

 Release Activity: max ADR, max Acute Eco, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

EPA SANITIZED Page 34 of 37
6/3/2009 Page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090373cation 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 3 Number of Sites RELEASE ACTIVITY max 

ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: POTW's (All facilities) 

SIC-CODE (S): 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 125.56 44.02 26.80 22.53 16.18 46.16 75.81 90.18 

ALL 10 11.11 1.94 1.06 0.96 182.88 1047.29 1916.75 2116.41 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 3.46E-06 3.91E-05 mg/kg/day 0.00 0.00 mg/kg/day 

LADCpot 1.77E-04 2.00E-03 mg/L 0.00 0.00 mg/kg 

Acute 

ADRpot 3.86E-03 8.75E-02 mg/kg/day 0.00 0.00 mg/kg/day 

SIC Code Comments: 

EPA SANITIZED Page 35 of 37
6/3/2009 Page of 

INITIAL EXPOSURE REVIEW REPORT 

Chemical ID: P090373cation 

DRINKING WATER EXPOSURE ESTIMATES FROM LANDFILL RELEASES 

SCENARIO #: 3 ACTIVITY: max ADR, max Acute Eco, max LADD 

RELEASE DESCRIPTION: 

EXPOSED POPULATION: Adult 

NUMBER 

OF 

SITES 

NON-SLUDGE 

LANDFILL 

RELEASE AND 

DAYS OF 

RELEASE 

(kg/site/day)/(days) 

 LANDFILLED 

SLUDGE1 

AND DAYS OF 

RELEASE 

(kg/site/day)/(days)

MIGRATION 

DESCRIPTOR2

ADSORPTION 

TO 

WASTEWATER 

SLUDGE 

 (%) 

DRINKING 

WATER 

TREATMENT 

 (%) 

 Slow 0.00 0.00 

 1 Landfilled sludge equals the fraction adsorbed to wastewater treatment sludge times the surface 

 water pre-treatment release.

 

 2 Migration Descriptor Log Koc Groundwater Concentration (GWC) 

 (mg/L per kg release)

 Negligible no migration None 

Negligible to slow > 4.5 3.21E-6 

Slow <4.5 to 3.5 2.67E-5 

Moderate <3.5 to 2.5 5.95E-5 

Rapid <2.5 7.55E-5 

 

ASSUMPTIONS 

 Exposure Units Results ED 

(years) 

AT 

(years) 

BW 

(kg) 

IR 

 (L/day) 

Cancer 

LADDpot (mg/kg/day) 6.55E-05 30.00 75.00 71.80 1.40 

LADCpot (mg/L) 3.36E-03 30.00 75.00 NA NA 

REMARKS: 

 

EPA SANITIZED Page 36 of 37
6/3/2009 Page of 

LEGEND FOR NEW CHEMICALS EXPOSURE REPORT 

This new chemicals exposure report was prepared by the Exposure Assessment Branch (EAB) of the Economics, 

Exposure and Technology Division, Office of Pollution Prevention and Toxics, USEPA. 

The goals of these reports are to calculate conservative (protective) estimates of exposure endpoints for consumers, 

the general population, and the environment. 

For each exposure scenario to industrial releases, the following three endpoints are calculated: 

(1) maximum possible acute concentrations and doses 

(2) maximum possible chronic concentrations and doses 

(3) for water releases ≥ 20 days, the probability of exceedence of the aquatic concentration of concern 

These endpoints are identified by abbreviations on the Release Activity line, e.g., (1) max ADR, (2) max 

LADD, (3) max PDM. Depending on the release inputs, these endpoints may be calculated and presented on 

the same page or different pages. That is, a release activity ID of mfg; max ADR, max PDM, max LADD

indicates that all the exposure endpoints were calculated from common manufacturing release values; 

conversely, a release activity ID of mfg &proc; max ADR indicates that only the maximum acute exposure 

values were calculated for manufacturing and processing releases that occurred at the same site. 

For each consumer product use exposure scenario, whether exposure is to the user directly or to the general 

population/environment, the maximum exposure values are calculated and presented together. 

In addition to the exposure values above, EPA policy directs that exposure and release values be compared to 

criteria threshold values for Exposure-based and PBT Exposure-based cases. 

Exposure-based (YX) cases (those with ≥ 100,000 kg/yr production volume) 

Criteria are exceeded under the following conditions: 

 Presence in consumer product with likely exposure 

≥ 3E-3 mg/kg/d exposure via air, fish ingestion or drinking water 

≥ 10,000 kg/yr release to environment (post-treatment) 

≥ 1,000 kg/yr release to water (post-treatment) 

Persistent, Bioaccumulative, Toxic (PBT) chemicals of P2B2 rating or higher and production volume ≥ 20,000 kg/yr 

Criteria are exceeded as for YX cases, with the following differences: 

≥ 2,000 kg/yr release to environment (post-treatment) 

≥ 200 kg/yr release to water (post-treatment) 

Bolding rules in the Report: Values for endpoints above that are also health or eco concerns are bolded. 

EPA SANITIZED Page 37 of 37