<PAGE>

                                                                   EXHIBIT 10.29

                               AGREEMENT OF LEASE

                              ENTERED INTO BETWEEN

                         SHIBBOLET (PROPRIETARY) LIMITED

                                       AND

                   QUINTILES CLINDEPHARM (PROPRIETARY) LIMITED

Jointly referred to as the Parties.

<PAGE>

                                      INDEX

                               AGREEMENT OF LEASE

<TABLE>
<CAPTION>
------------------------------------------------------------------------------
NO                               CLAUSE HEADINGS                          PAGE
------------------------------------------------------------------------------
<S>         <C>                                                           <C>
1           Parties
2           Interpretation
3           Recordance
4           Letting and Hiring
5           Duration
6           Rental
7           Operating Costs
8           Increase in the Rates
9           Additional Charges
10          Electricity
11          Deposit
12          Insurance
13          Assignment and Subletting
14          Sundry Obligations of the Lessee
15          Maintenance and Repairs
16          Alterations, Additions and Improvements
17          Exclusion of Lessor's Liability and Indemnity
18          Lessor's Rights
19          Area of the Premises
20          Rules
21          Parking and Loading
22          Damage to or Destruction of Premises
23          Special Remedy for Breach
24          Option of Renewal
25          New Tenants and Purchasers
26          Costs
27          Domicilia and Notices
28          Whole Agreement
29          Non-Waiver
30          Warranty of Authority
31          Merchants' Association
32          Security for Payment by Lessee
33          Sale of Premises
</TABLE>

LEASE(QUINTILES)                        2                        7 DECEMBER 1999

<PAGE>

                               AGREEMENT OF LEASE

1.       PARTIES:

         The parties to this lease are:

1.1      Shibbolet (Proprietary) Limited

         ("the Lessor"); and

1.2      Quintiles Clindepharm (Proprietary) Limited

         ("the Lessee").

2.       INTERPRETATION:

2.1      In this Agreement, except in a context indicating that some other
         meaning is intended:

         2.1.1    "THIS AGREEMENT" means this Agreement together with all
                  appedicis and annexures;

         2.1.2    "ASSOCIATE" in relation to the Lessee means a company, which
                  is for the time being:

                  2.1.2.1  a subsidiary or holding company of the Lessee within
                           the meaning ascribed to such terms in the Companies
                           Act 61 of 1973; or

                  2.1.2.2  a subsidiary or holding company of a company referred
                           to in 2.1.2.1 above;

         2.1.3    "THE BUILDING" means the buildings known as Centurion Science
                  Park, Phases I to IV, situated on the Property, and includes,
                  where the context so allows, all permanent improvements on the
                  Property;

         2.1.4    "COMMON AREAS" means portions of the Building which are not
                  suitable for letting and are not actually let by the Lessor;

         2.1.5    "DAY" means any day of the week, excluding Saturdays, Sundays
                  and public holidays;

LEASE(QUINTILES)                        3                        7 DECEMBER 1999

<PAGE>

         2.1.6    "THE LEASE PERIOD" means the period for which this lease
                  subsists, including any period for which it is renewed;

         2.1.7    "THE LESSOR" means Shibbolet (Proprietary) Limited, a company
                  duly incorporated in terms of the Company Laws of the Republic
                  of South Africa;

         2.1.8    "THE LESSEE" means Quintiles Clindepharm (Proprietary)
                  Limited, a company duly incorporated in terms of the Company
                  Laws of the Republic of South Africa;

         2.1.9    "MONTH" means a calendar month, and more specifically

                  2.1.9.1  in reference to a number of months from a specific
                           date, a calendar month commencing on that date or the
                           same date of any subsequent month; and

                  2.1.9.2  in any other context, a month of the calendar, that
                           is, one of the 12 months of the calendar,

                  2.1.9.3  and "monthly" has the corresponding meaning;

         2.1.10   "OPTION PERIOD" means the period referred to in clause 24;

         2.1.11   "THE PARTIES" means the parties to this Agreement;

         2.1.12   "THE PREMISES" means Phases I, II, III and IV of Centurion
                  Science Park, further identified by the annexed plans signed
                  by the parties and having a Rentable Area of 2328 (Two
                  Thousand Three Hundred and Twenty Eight square metres;) and
                  also including the parking areas as set out in 21 and in
                  respect of which the Premises shall comprise air conditioned
                  offices as they existed at the commencement date.

         2.1.13   "THE PROPERTY" means Erf 1831, Lyttelton Manor X 3, Centurion,
                  including the Premises;

         2.1.14   "THE PRIME RATE" means the public quoted basic rate of
                  interest per annum (as certified by any manager of

LEASE(QUINTILES)                        4                        7 DECEMBER 1999

<PAGE>

                  ABSA Bank) at which that bank lends on unsecured overdraft to
                  its most favoured customers in the private bank sector,
                  compounded monthly in arrears and calculated on a 365 (three
                  hundred and sixty five) day year factor irrespective of
                  whether the year is a leap year of not;

         21.15    "THE RATES" means the assessment rates and all taxes of what
                  so ever nature payable on the Property and includes any other
                  charges payable by the Lessor to the local authority (such as,
                  but not limited to, refuse removal charges or sanitary fees),
                  but not charges for water, electricity or gas;

         2.1.16   "RENTABLE AREA" in relation to the Premises means the area of
                  the Premises determined in accordance with clause 19;

         2.1.16   "YEAR" means a period of 12 consecutive months, and "yearly"
                  refers to a year commencing on the date on which the lease
                  comes into operation or any anniversary of that date;

2.2      references to notices, statements and other communications by or from
         the Lessor include notices by or from the Lessor's agent;

2.3      expressions in the singular also denote the plural, and vice versa;

2.4      words and phrases denoting natural persons refer also to juristic
         persons, and vice versa; and

2.5      Pronouns of any gender include the corresponding pronouns of the other
         gender;

2.6      If any provision in a definition is a substantive provision conferring
         rights or imposing obligations on any party, notwithstanding that it
         appears in the definition clause only, effect shall be given to it as
         if it were a substantive provision in the body of the agreement.

2.7      Words and expressions defined in any sub-clause shall, for the purpose
         of the clause of which that sub-clause forms part, bear the meaning
         assigned to such words and expressions in that sub-clause.

2.8      If a particular number of days are referred to in this agreement, such
         number of days shall be reckoned exclusively of the first day and
         inclusively of the last day of the number of days, which is specified.

LEASE(QUINTILES)                        5                        7 DECEMBER 1999

<PAGE>

2.9      Any provision of this lease imposing a restraint, prohibition or
         restriction on the Lessee shall be so construed that the Lessee is not
         only bound to comply therewith but is also obliged to procure that the
         same restraint, prohibition or restriction is observed by everybody
         occupying or entering the Premises or any other part of the Property or
         the Building through, under, by arrangement with, or at the invitation
         of, the Lessee, including (without limiting the generality of this
         provision) its Associates and the directors, members, officers,
         employees, agents, customers and invitees of the Lessee or its
         Associates.

2.10     Clause headings appear in this lease for purposes of reference only and
         shall not influence the proper interpretation of the subject matter.

2.11     This lease shall be interpreted and applied in accordance with South
         African law.

3.       RECORDANCE:

         It is recorded that:

3.1      The Lessor is the owner of the Property;

3.2      The Lessee wishes to hire and the Lessor wishes to lease, the Property;

3.3      This Agreement sets out the terms and conditions agreed upon between
         the parties in relation to such lease.

4        LETTING AND HIRING:

         The Lessor lets and the Lessee hires the Premises on the terms of this
         Agreement.

5        DURATION:

         This Agreement shall:

5.1      come into operation on 1 December 1999 (the commencement date) and
         shall subsist for 6 (Six) years and 4 (Four) months notwithstanding the
         date of signature hereof;

LEASE(QUINTILES)                        6                        7 DECEMBER 1999

<PAGE>


5.2      terminate, unless renewed in terms of 5.3, on 31 March 2006;

5.3      be renewable at the option of the Lessee for a further period of 5
         (Five) years.

5.4      The option contained in 5.3 shall be exercisable on notice, as provided
         for in this Agreement and in terms of the provisions as set out in 24,
         by the Lessee to the Lessor given not less than 6 (six) months prior to
         the date on which this Agreement would expire if it were not for the
         exercise of such option.

6.       RENTAL:

6.1      The monthly rental payable by the Lessee to the Lessor:

         6.1.1    in respect of the Premises during the period commencing on the
                  commencement date and ending on the day prior to the first
                  anniversary of the commencement date or, if the commencement
                  date does not fall on the first day of a month, on the last
                  day of the month in which the first anniversary of the
                  commencement date falls, shall be R 39.00 (Thirty Nine Rand)
                  per square meter amounting to a total rental of R 90 792.00
                  (Ninety Thousand Seven Hundred and Ninety Two Rand) per month;

         6.1.2    in respect of the Premises on 1 April 2000 a rental of 10%
                  (Ten per centum) higher than the rental payable in respect of
                  the property for the final month of the preceding year and
                  thereafter in respect of each subsequent year during the
                  initial period, commencing on 1 April 2000, a rental of 10%
                  (Ten per centum) higher than the rental payable in respect of
                  the property for the final month of the preceding year.

6.2      Should the Lessee exercise the option contained in 5.3, the rental
         during the option period shall be such rental as may be agreed upon in
         writing between the Lessor and the Lessee or, failing such agreement
         between the Lessor and the Lessee within 3 (three) months after the
         date of the exercise of such option, a fair market rental determined in
         accordance with the applicable provisions of this clause 6.

6.3      For the purpose of 6.2, the fair market rental of the property during
         the option period shall be deemed to be the rental which a willing
         Lessee would be prepared to pay a willing Lessor in respect of the
         property for the option period, if agreed upon on the date of receipt
         by the Lessor of the notice referred to in 5.4, and as determined by

LEASE(QUINTILES)                        7                        7 DECEMBER 1999

<PAGE>

         an expert agreed upon in writing between the Lessor and the Lessee for
         that purpose or, failing agreement between them within 14 (fourteen)
         days, as determined by an expert nominated for that purpose at the
         request of the Lessor or the Lessee by the president of The South
         African Institute of Estate Agents.

6.4      Notwithstanding the provision of 6.3, should either the Lessor or the
         Lessee be dissatisfied with the fair market rental determined by the
         expert agreed upon or nominated in terms of 6.3, and the party who is
         so dissatisfied ("THE DISSATISFIED PARTY") notify the other party
         within 14 (fourteen) days after the determination of such expert of his
         dissatisfaction, then the matter shall be referred to another expert
         nominated by the president of the South African Institute of Estate
         Agents for the determination of such fair market rental.

6.5      Should the fair market rental of the property as determined by the
         expert nominated in terms of 6.4 ("THE SECOND EXPERT"):

         6.5.1    not be 10% (Ten per centum) more or less than the fair market
                  rental of the property as determined by the expert agreed upon
                  or nominated in terms of 6.3 ("THE FIRST EXPERT"), then:

                  6.5.1.1       the fair market rental of the property shall be
                                deemed to be the fair market rental of the
                                property as determined by the first expert;

                  6.5.1.2       the dissatisfied party shall pay all costs
                                incurred in connection with the services
                                rendered by the second expert;

         6.5.2    be 10% (ten per centum) more or less than the fair market
                  rental as determined by the first expert, then:

                  6.5.2.1       the fair market rental of the property shall be
                                deemed to be the average of the fair market
                                rentals of the property as determined by the
                                first and second experts;

                  6.5.2.2       in the event of the fair market rental of the
                                property as determined by the second expert
                                being higher than the fair market rental of the
                                property as determined by the first expert, the
                                Lessee shall pay all costs incurred in
                                connection with the services rendered by the
                                second expert;

                  6.5.2.3       in the event of the fair market rental of the
                                property as determined by the second expert
                                being lower than the fair market rental of the
                                property as determined by the first expert, the
                                Lessor shall pay all

LEASE(QUINTILES)                        8                        7 DECEMBER 1999

<PAGE>

                         costs incurred in connection with the services rendered
                         by the second expert.

6.6      For the purposes of the preceding provisions of this 7, should:

         6.6.1    the Lessor notify the Lessee that it is prepared to agree to
                  the fair market rental of the property being deemed to be
                  less; or

         6.6.2    the Lessee notify the Lessor that it is prepared to agree to
                  the fair market rental of the property being deemed to be more
                  than the fair market rental of the property as determined by
                  the first expert, within 7 (seven) days after the
                  determination of the first expert, then the fair market rental
                  of the property as determined by the first expert shall be
                  deemed to be the higher or lower rental notified by the Lessor
                  or Lessee to the Lessee or Lessor (as the case may be).

6.7      The costs incurred in respect of the services rendered by the first
         expert shall be borne and paid by the parties in equal shares.

6.8      Any additional amount payable by the Lessee in respect of Operating
         Costs, Rates and Additional Charges, in terms of 7,8 and 9 shall be
         added to the rental payable by the Lessee, and:

         6.8.1    the Lessee shall be liable to pay such increased rental;

         6.8.2    the terms and conditions of this agreement in respect of
                  rental generally shall apply mutatis mutandis to such
                  increased rental.

6.9      The rentals referred to above are exclusive of value-added tax, and the
         Lessee shall, in addition to the rental, be liable for the payment of
         value-added tax thereon.

6.10     The aforesaid rental shall be paid monthly in advance on the first day
         of each and every month, without deduction or set-off and free of
         exchange to the Lessor at ABSA Bank Lyttelton Account Number 600 164
         570, or at such other place in Gauteng as the Lessor may direct in
         writing.

6.11     All amounts payable by the Lessee to the Lessor in terms of this
         agreement, and which are not paid on the due date thereof shall,
         without prejudice to any rights which the Lessor may otherwise have,
         bear interest with effect from the due date of such payment at the
         prime rate, for the period that elapses from such due date up to and
         until 5 (five) days after date of the letter of demand and thereafter
         such an amount shall bear interest at a rate per annum of 400 (Four
         hundred) basis points higher than the prime rate until date of final

LEASE(QUINTILES)                        9                        7 DECEMBER 1999

<PAGE>

         payment.

6.12     The Lessee shall not withhold, defer, or make any deduction from any
         payment due to the Lessor, whether or not the Lessor is indebted to the
         Lessee or in breach of any obligation to the Lessee.

7.       OPERATING COSTS:

7.1      For the purposes of this clause 7:

         7.1.1    "THE OPERATING COSTS" means the reasonable costs (for which
                  the Lessee is not otherwise liable in terms of this lease)
                  incurred by the Lessor in connection with the ownership,
                  management, maintenance, repair and operation of the Property
                  and the Building, including, but not limited to, the Rates and
                  the costs of:

         7.1.1.1  cleaning the Building and the Property;

         7.1.1.2  providing security in respect of the Building;

         7.1.1.3  maintaining lifts and escalators, if any;

         7.1.1.4  providing electricity, water, gas, oil or any necessary
                  service to Common Areas

         7.1.1.5  maintaining internal roofs, walls and finishes

         7.1.1.6  gardens and gardening services and maintenance.

7.2      All the above Operating Costs are not included in the rental amount as
         set out in 6 above and until such time as these costs are incurred by
         the Lessor, in terms of a further written agreement, the Lessee shall
         be responsible for such services at its own cost.

8.       INCREASES IN THE RATES:

8.1      Whenever the Rates are increased during the Lease Period, the Lessor
         may, by written notice to the Lessee, increase the monthly rent for the
         Premises by an amount which bears the same ratio to the increase in
         Rates, calculated on a monthly basis, as the rent payable by the Lessee
         for the Premises bears for the time being to the total rentals
         receivable by the Lessor from all tenants of the Building. Every such
         increase in the rent shall take effect on the first day of the

LEASE(QUINTILES)                       10                        7 DECEMBER 1999

<PAGE>

         month following that in which the Lessor's notice of the increase is
         received by the Lessee or, whichever is the later, the date on which
         the corresponding increase in the Rates takes effect.

8.2      For the purposes of 8.1, any premises in the Building which are not
         part of the Common Areas but are unlet for the time being shall be
         deemed to be let for the rental that was last receivable by the Lessor
         for the same premises or, if they were never let, a fair market rental
         determined in good faith by a reputable estate agent appointed by the
         Lessor).

9.       ADDITIONAL CHARGES:

9.1      In addition to paying the rent and other amounts, the Lessee shall
         reimburse the Lessor, monthly in arrear, within 7 (Seven) days after
         receiving an account from the Lessor reflecting the amount(s) so
         payable, with the cost of water consumed on the Premises, determined at
         prevailing municipal rates in accordance with readings of separate
         submeters or, if there are no such submeters, on the basis of the
         Lessee being liable to bear 100 % ( One Hundred percent) of the total
         cost of all water consumed on the Property.

9.2      If any additional levy, not dealt with under 7,8 and 9, payable by the
         Lessor in respect of the Property, Building or Premises, be increased
         from time to time during the duration of this lease so as to exceed the
         amount of such levy as at the commencement date; or a new levy or
         impost cost or expense of whatsoever nature, not in force as at
         commencement date, be imposed at any time thereafter on the Lessor, by
         virtue of its being the owner of the property, then the Lessor shall be
         entitled to increase the monthly rental for the property by an amount
         equal to one-twelfth of the yearly amount of that increase or new levy
         or impost multiplied by the Lessee's Contribution Percentage being an
         increase in respect of an item, charge or cost as contemplated by 6.8
         with effect from the date upon which that increase or new levy or
         impost takes effect.

10.      ELECTICITY:

         The Lessee shall be responsible for the payment of all electricity
         charges related to the Premises and in this regard such electricity
         consumption shall be determined by separate meter allocated to the
         Premises.

LEASE(QUINTILES)                       11                        7 DECEMBER 1999

<PAGE>

11.      DEPOSIT:

11.1     On entering into this Agreement the Lessee shall pay the Lessor a
         deposit of R 0.00 ( Nil Rand), which amount the Lessor may apply, in
         whole or part, in meeting any payment due by the Lessee to the Lessor
         at any time during the Lease Period or after the termination of this
         Agreement.

11.2     Whenever during the Lease Period the deposit is so applied in whole or
         part, the Lessee shall on demand reinstate the deposit to its original
         amount.

11.3     As soon as all the obligations of the Lessee to the Lessor have been
         discharged following the termination of this Agreement, the Lessor
         shall refund to the Lessee, free of interest, so much of the deposit as
         has not been applied in terms of the above provisions.

12.      INSURANCE:

12.1     The Lessee shall not keep or do in or about the Property, Building or
         Premises anything which is liable to enhance any of the risks against
         which the Property or Building is insured for the time being to the
         extent that such insurance is rendered void or voidable or the premiums
         of such insurance are, or become liable to be, increased.

12.2     Without prejudice to any other right of action or remedy which the
         Lessor may have arising out of a breach of the aforegoing provision,
         the Lessor may recover from the Lessee on demand the full amount of any
         increase in insurance premiums in respect of the Property or Building
         attributable to such breach.

13.      ASSIGNMENT AND SUBLETTING:

13.1     The Lessee shall not be entitled, except with the prior written consent
         of the Lessor to:

         13.1.1   cede or assign all or any of the rights or obligations of the
                  Lessee under this Agreement; or

         13.1.2   sublet or give up possession of the Premises, in whole or
                  part, to any third party which is not an Associate of the
                  Lessee.

13.2     The Lessor shall be entitled, in its sole and absolute discretion, to

LEASE(QUINTILES)                       12                        7 DECEMBER 1999

<PAGE>

         withhold its consent to the subletting of the whole or part of the
         Premises by the Lessee to any other entity.

14.      SUNDRY OBLIGATIONS OF THE LESSEE:

         The Lessee shall:

14.1     keep the Premises clean and tidy;

14.2     not use the Premises or allow it to be used, in whole or part, for any
         purpose other than that of offices and laboratory facilities;

14.3     not place or leave any article or other thing in or about any passage,
         lift, stairway, pathway, parking garage, or other common part of the
         Property or Building so as to cause a nuisance or obstruction;

14.4     not bring into or unto the Property, Building or Premises any article
         which, by reason of its weight or other characteristics, is liable to
         cause damage to the Property, Building or Premises;

14.5     not contravene any of the conditions of title of the Property or any of
         the laws, rules or regulations affecting owners, tenants or occupiers
         of the Property or the Building and specifically any measure having the
         force of law with which the Lessor is obliged to comply as owner of the
         Property including without limiting the generality hereof all laws
         relating to environmental protection which may apply to the Lessee in
         general or specifically due to the nature of the Lessee's business;

14.6     not cause or commit any nuisance on the Property or in the Building or
         Premises or cause any annoyance or discomfort to other tenants or
         occupiers of the Property or Building;

14.7     not leave refuse or allow it to accumulate in or about the Property,
         Building or Premises except in the refuse bins provided;

14.8     refrain from interfering with the electrical, plumbing or gas
         installations or systems serving the Property, Building or Premises,
         except as may be necessary to enable the Lessee to carry out its
         obligations of maintenance and repair in terms of this Lease and then
         the Lessee shall only utilise persons properly qualified;

14.9     take all reasonable measures to prevent blockages and obstructions from
         occurring in the drains, sewerage pipes and water pipes serving the
         Property, Building or Premises;

LEASE(QUINTILES)                       13                        7 DECEMBER 1999

<PAGE>

14.10    provide at the Lessee's own expense all electric, fluorescent and
         incandescent light bulbs required in the Premises;

14.11    be responsible for all glass, both internal and external, on the
         Premises, including all mirrors, office fronts, and window panels;

14.12    keep the office fronts of the Premises illuminated during such
         reasonable hours as the Lessor may from time to time in writing direct;

14.13    procure that the decor of the Premises is maintained at a level which
         is in keeping with the standards of the Property and Building;

14.14    not paint, affix or attach to the Premises or any part of the Building
         any sign, notice, awning or canopy without the Lessor's prior written
         consent, which shall not be unreasonably withheld;

14.15    keep any such sign, notice, awning or canopy which has been so approved
         by the Lessor in good order, condition and repair at all times;

14.16    not erect any radio or television aerial on the roof or exterior walls
         of the Premises or the Building without the Lessor's prior written
         consent, which shall not be unreasonably withheld;

14.17    on the termination of this Agreement reinstate and return the property
         to the Lessor in the same good order and condition (fair wear and tear
         excepted) as it was in as at the commencement date;

14.18    have no claim of any nature whatsoever for any loss or damages which
         the Lessee may suffer, including cancellation of this lease, as a
         result of:

         14.18.1       any defect in the property or any part thereof or any
                       improvement thereon;

         14.18.2       vis major, casus fortuitus or any other causes which is
                       either wholly or substantially outside the control of the
                       Lessor;

         14.18.3       not do anything , which will damage the property or any
                       of the improvements thereon;

14.19    be responsible during the duration of this Agreement for obtaining and
         renewing all licenses, permits or other consents in respect of the
         Lessee's business, and the failure to obtain such licenses or permits
         shall not be a ground for the cancellation of this Agreement by the

LEASE(QUINTILES)                       14                        7 DECEMBER 1999

<PAGE>

         Lessee; and

14.20    take out and maintain public liability insurance for an amount which,
         having regard to the nature of the Lessee's business, a prudent
         businessman would take out and maintain.

15.      MAINTENANCE AND REPAIRS:

15.1     The Lessee shall at its own expense and without recourse to the Lessor:

         15.1.1   throughout the Lease Period maintain in good order and
                  condition the interior of the Premises and all parts thereof,
                  including (without limitation of the generality of this
                  obligation) all shop fronts, windows, doors, appurtenances,
                  fixtures and fittings contained in the Premises;

         15.1.2   be responsible for all repairs of and maintenance to the
                  parking bays and shade netting associated with such parking
                  bays as set out in 21.5;

         15.1.3   promptly repair or make good all damage occurring in the
                  Premises from time to time during the Lease Period, whatever
                  the cause of such damage, and including damage to any part of
                  the interior of the Premises or to any shop front, window,
                  door, appurtenance, fixture or fitting, and replace all such
                  items (as well as any keys) which have been broken, lost or
                  destroyed (again regardless of cause); and

         15.1.4   on the termination of this lease, howsoever and whenever it
                  terminates, return the Premises and all such parts thereof
                  (including all keys) to the Lessor in good order, condition
                  and repair, fair wear and tear excepted.

 15.2    If the Lessee notifies the Lessor in writing within 5(Five) days after
         having taken possession of the Premises of the need for any repairs to
         or in the Premises or of the fact that any part of the Premises,
         including any lock, key, door, shop front, window, appurtenance,
         fixture or fitting, is damaged, missing, or out of order, the Lessor
         shall promptly cause the necessary repair or replacement to be effected
         at the Lessor's own expense. If or in so far as the Lessee does not
         give such notice, the Lessee shall be deemed to have acknowledged that
         the Premises and all parts thereof were intact, in

LEASE(QUINTILES)                       15                        7 DECEMBER 1999

<PAGE>

         place, and in good order, condition and repair when the Lessee took
         possession of the Premises under this lease.

15.3     The Lessor shall be responsible for the maintenance of, and for all
         repairs and replacements becoming necessary from time to time in or to,
         the Building and all parts thereof other than those which are the
         responsibility for the time being of tenants or of the local authority,
         and the Lessor's obligations in this respect shall include the
         maintenance and repair of the structure of the Building, all systems,
         works and installations contained therein, the roofs, the exterior
         walls, the lifts, the grounds and gardens, and all other parts of the
         Common Areas, provided that maintenance of the grounds and gardens and
         all other parts of the Common Areas will only commence once the Lessor
         has taken over responsibility for such, based on a further written
         agreement between the parties, and until such time as the
         responsibility is so taken over by the Lessor the Lessee shall be
         responsible for such maintenance at its own cost.

15.4     The Lessor shall not, however, be in breach of clause 15.3 in so far as
         any of its obligations thereunder are not or cannot be fulfilled by
         reason of any vis maior or the acts or omissions of others over whom
         the Lessor has no direct authority or control, and where the Lessor is
         indeed in breach of clause 15.3, the Lessee's only remedy against the
         Lessor shall be a right of action for specific performance.

15.5     Should the Lessee fail to carry out any of its obligations under this
         Agreement with regard to any maintenance, repair or replacement, the
         Lessor shall be entitled, without prejudice to any of its other rights
         or remedies, to effect the required item of maintenance, repair or
         replacement and to recover the cost thereof from the Lessee on demand.

16.      ALTERATIONS, ADDITIONS AND IMPROVEMENTS:

16.1     The Lessee shall not make any alterations or additions to the Premises
         without the Lessor's prior written consent, but the Lessor shall not
         withhold its consent unreasonably to an alteration or addition which is
         not structural.

16.2     If the Lessee does alter, add to, or improve the Premises in any way,
         whether in breach of 16.1 or not, the Lessee shall, if so required in
         writing by the Lessor, restore the Premises on the termination of this
         Agreement to its condition as it was prior to such alteration, addition
         or improvement having been made. The Lessor's requirement in this
         regard may be communicated to the Lessee at any time, and this

LEASE(QUINTILES)                       16                        7 DECEMBER 1999

<PAGE>

         16.2 shall not be construed as excluding any other or further remedy
         which the Lessor may have in consequence of a breach by the Lessee of
         16.1.

16.3     Save for any improvement which is removed from the Premises as required
         by the Lessor in terms of clause 16.2, all improvements made to the
         Premises shall belong to the Lessor and may not be removed from the
         Premises at any time. The Lessee shall not, whatever the circumstances,
         have any claim against the Lessor for compensation for any improvement
         to the Premises, nor shall the Lessee have a right of retention in
         respect of any improvements.

17.      EXCLUSION OF LESSOR FROM CERTAIN LIABILITY AND INDEMNITY:

17.1     The Lessee shall have no claim for damages against the Lessor and may
         not withhold or delay any payment due to the Lessor by reason directly
         or indirectly of:

         17.1.1   a breach by the Lessor of any of its obligations under this
                  Agreement;

         17.1.2   any act or omission of the Lessor or any agent or servant of,
                  or contractor to, the Lessor, whether or not negligent, or
                  otherwise actionable at law, and including (without limiting
                  the generality of the aforegoing) any act or omission of any
                  cleaner, maintenance person, handyman, artisan, labourer,
                  workman, watchman, guard, or caretaker;

         17.1.3   the condition or state of repair at any time of the Property,
                  the Building, or any part of the Property or the Building;

         17.1.4   any failure or suspension of, or any interruption in, the
                  supply of water, electricity, gas, air-conditioning, heating,
                  or any other amenity or service to the Premises, the Building,
                  or the Property (including, without generality being limited,
                  any cleaning service), whatever the cause;

         17.1.5   any breakdown of, or interruption in the operation of, any
                  machinery, plant, equipment, installation or system situated
                  in or on, or serving the Property, the Building, or the
                  Premises, and including (but without limiting the

LEASE(QUINTILES)                       17                        7 DECEMBER 1999

<PAGE>

                  generality of the aforegoing) any lift, escalator, geyser,
                  boiler, burglar alarm, or security installation or system,
                  again regardless of cause;

         17.1.6   any interruption of, or interference with, the enjoyment or
                  beneficial occupation of the Premises or any of the Common
                  Areas of the Property or the Building caused by any building
                  operations or other works to or in the Building or elsewhere
                  on or about the Property, whether by the Lessor or by anybody
                  else; or

         17.1.7   any other event or circumstance whatever occurring, or failing
                  to occur, upon, in, or about the Property, the Building, or
                  the Premises, whether or not the Lessor could otherwise have
                  been held liable for such occurrence or failure,

         17.1.8   and the Lessee indemnifies the Lessor against all liability to
                  any of the associates, directors, members, agents, customers,
                  servants, guests and other invitees of the Lessee or of any of
                  its Associates, and all other persons who may enter upon the
                  Premises or any parts thereof through or under the Lessee, in
                  consequence of any such matter as is referred to in clauses
                  17.1.1 to 17.1.7 above and further indemnifies the Lessor
                  against any claim made against the Lessor by anyone for any
                  loss or damage suffered in or on the property or in
                  consequence of any act or omission of the Lessee's servants or
                  agents.

17.2     The Lessor shall not, however, be excused from specific performance of
         any of its obligations under this Agreement, whether express or
         implied, and particularly (but not only) its obligations to afford the
         Lessee occupation and enjoyment of the Premises as contemplated by this
         Agreement and to carry out such maintenance and repairs as are
         incumbent upon the Lessor in terms hereof.

17.3     The Lessor does not warrant that the Premises are suitable for the
         purposes of the Lessee or any of its Associates or that the Lessee or
         any of its Associates will be granted any licence or consent which may
         be necessary for the carrying on of any business or activity in the
         Premises.

LEASE(QUINTILES)                       18                        7 DECEMBER 1999

<PAGE>

18.      LESSOR'S RIGHTS:

18.1     The Lessor's representatives, agents, servants and contractors may at
         all reasonable times, without thereby giving rise to any claim or right
         of action on the part of the Lessee or any other occupier of the
         Premises:

         18.1.1   enter the leased Premises in order to inspect them, to carry
                  out any necessary repairs, replacements or other works, or to
                  perform any other lawful function in the bona fide interests
                  of the Lessor or any of the occupiers of the Property; or

         18.1.2   carry out elsewhere in the Building or on the Property any
                  necessary repairs, replacements or other works;

         but the Lessor shall ensure that this right is exercised with due
         regard for, and a minimum of interference with, the beneficial
         enjoyment of the Premises by those in occupation thereof.

18.2     The Lessor shall have the right:

         18.2.1   to display at the property:

                  18.2.2.1      a "TO LET" notice during the period of 6
                                (six) months immediately preceding the
                                termination of the lease;

                  18.2.2.2      a "FOR SALE" notice at any time during the
                                currency of this lease;

         18.2.2   to show any prospective tenants or buyers of the property
                  the property on reasonable notice during reasonable hours
                  on business days;

         18.2.3   to display on the property any notice which may be required
                  by the Lessor or any of the tenants or prospective tenants of
                  the Lessor in connection with any applications for a license
                  for any business to be carried on, on the property;

19.      AREA OF THE PREMISES:

19.1     If it is necessary in terms of this lease to determine the area, in
         square metres, of the Premises or any other part of the Building, such
         determination shall be made according to the SAPOA standard method for
         measuring floor areas. Any dispute between the Lessor

LEASE(QUINTILES)                       19                        7 DECEMBER 1999

<PAGE>

         and the Lessee as to any such area shall be determined by an
         independent architect, acting as expert and not arbitrator, whose
         certificate as to such area shall be final and binding on the parties.
         If the parties fail to agree on the identity of such architect, he
         shall be appointed by the Executive Director for the time being of the
         South African Institute of Architects.

19.2     The party who declares a dispute in relation to the square meters, as
         set out in 2.1.12, shall be responsible for the cost incurred relating
         to the determination by the independent Architect as contemplated
         above, in the event that such determination confirms the correctness of
         the square meters contain in 2.1.12. In the event that the independent
         architect determines a meterage other than that contained in 2.1.12,
         the cost of such determination shall be borne by the parties equally.

20.      RULES:

20.1     The Lessee shall at all material times comply with such reasonable
         rules and regulations as are laid down in writing by or on behalf of
         the Lessor for observance by tenants and other occupiers of the
         Property, their customers and their invitees, including (without
         generality being limited) rules and regulations in connection with:

         20.1.1   the security of the Property and the protection of persons and
                  property thereon, including in particular (again without
                  generality being restricted) any rules for the control and
                  identification of persons and vehicles entering the Property
                  or any parts thereof;

         20.1.2   the driving and parking of vehicles on or about the Property;

         20.1.3   the utilisation of common amenities and facilities on the
                  Property;

         20.1.4   the air-conditioning plant, if any, servicing the Building;

         20.1.5   the prohibition or restriction of specific activities and
                  practices which are actually or potentially detrimental to the
                  general interests of traders in the Building; and

         20.1.6   the loading and off-loading of merchandise and other articles
                  on and about the Property.

LEASE(QUINTILES)                       20                        7 DECEMBER 1999

<PAGE>

20.2     20.1 shall not be construed as implying that the Lessor assumes any
         liability, which it would not otherwise have had in connection with the
         subject matter of any such rule or regulation.

21.      PARKING AND LOADING:

21.1     The Lessee shall throughout the Lease Period have the exclusive use for
         its directors, officers, members, partners, employees, clients,
         customers and invitees of 28 (Thirty One) covered parking bays/garages
         as identified on the plan being A5, at an initial monthly rental of R
         120.00 (One Hundred and Twenty Rand) per bay, payable in addition to,
         and increasing from time to time simultaneously with and
         proportionately to, the rent and or other increases as contemplated in
         7,8 and 9 for the Premises (whatever the cause or basis of such
         increase).

21.2     All the terms of this Agreement relating to the Premises themselves
         shall apply mutatis mutandis to the loading bay(s) and parking
         bay(s)/garage(s) referred to in 21.1 except those which are obviously
         inapplicable.

21.3     Without derogation from any rules or regulations in force for the time
         being as envisaged in 20.1, the Lessee shall procure that the loading
         and off-loading of merchandise and other articles in connection with
         the business carried on in the Premises are carried out:

         21.3.1   only in the bay(s) let to the Lessee in terms of 21.1 and such
                  other loading bay(s)/area(s) as are provided for the purpose;
                  and

         21.3.2   with due regard and consideration for the interests of other
                  traders in the Building and the general public.

21.4     The provisions of this 21, in respect of the lease of parking bays or
         additional parking bays, shall endure for the duration of this
         Agreement and shall terminate simultaneously with this Agreement.

21.5     The Lessor shall be responsible for the maintenance and upkeep of the
         covered parking bays but the Lessee shall specifically be responsible
         for all damage which may occur in respect of such parking bays,
         resulting from the wilful or negligent acts of its employees, clients
         or visitors, or any other person and the Lessee shall pay to the
         Lessor, on demand, all such costs incurred by the Lessor in the repair
         of damaged parking bays.

LEASE(QUINTILES)                       21                        7 DECEMBER 1999

<PAGE>

22.      DAMAGE TO OR DESTRUCTION OF PREMISES:

22.1     If the Building or Premises is destroyed or so damaged that the Lessee
         can no longer beneficially occupy the Premises, this lease shall
         terminate when that happens unless the parties agree otherwise in
         writing.

22.2     If the Premises is significantly damaged but can still be beneficially
         occupied, this Agreement shall remain in force and the Lessor shall
         repair the damage without undue delay, but the rent shall be abated so
         as to compensate the Lessee fairly for the effects of the damage and
         repair work on the enjoyment of the Premises. Failing agreement on such
         abatement or on the applicability of this clause to any particular
         circumstances, the matter shall be referred to an expert appointed by
         the parties jointly or, if they do not agree on such appointment,
         nominated by the President for the time being of The Institute of
         Estate Agents of South Africa, and the decision of such expert shall be
         final and binding. The expert's fees and disbursements, including any
         inspection costs, shall be borne and paid by the parties in equal
         shares. Pending determination of the abatement the Lessee shall
         continue to pay the full rent for the Premises as if they had not been
         damaged, and as soon as the matter has been resolved the Lessor shall
         make the appropriate repayment, if any, to the Lessee.

22.3     Subject to 17, if any damage to the Premises or the destruction thereof
         is caused by an act or omission for which either party is responsible
         in terms of this Agreement or in law, the other party shall not be
         precluded by reason of any of the aforegoing provisions of this 22 from
         exercising or pursuing any alternative or additional right of action or
         remedy available to the latter party under the circumstances (whether
         in terms of this Agreement or in law).

23.      SPECIAL REMEDY FOR BREACH:

23.1     Should the Lessee default in any payment due under this Agreement and
         fail to remedy such default within 5 (five) days after receiving a
         written demand that it be remedied; or

23.2     fail to pay any amount owing in terms of this Agreement on due date,
         but within 5 (five) days after receipt of a notice from the Lessor
         requiring such payment to be made, on more than 3 (three) occasions
         falling within any period of 12 (twelve) calendar months; or

LEASE(QUINTILES)                       22                        7 DECEMBER 1999

<PAGE>

23.3     commit any other breach of any term or condition of this Agreement and
         fail to remedy that breach within a period of 30 (thirty) days after
         receipt of a notice from the Lessor calling on the Lessee to do so,
         then, in any such event, the Lessor shall be entitled to cancel this
         Agreement, by notice to the Lessee, without prejudice to any rights,
         which the Lessor may have against the Lessee as a result thereof, then
         the Lessor shall be entitled, without prejudice to any alternative or
         additional right of action or remedy available to the Lessor under the
         circumstances without further notice, to cancel this Agreement with
         immediate effect, be possession of the Premises, and recover from the
         Lessee damages for the default or breach and the cancellation of this
         Agreement.

23.4     Clause 23.1 shall not be construed as excluding the ordinary lawful
         consequences of a breach of this Agreement by either party (save any
         such consequences as are expressly excluded by any of the other
         provisions of this Agreement) and in particular any right of
         cancellation of this Agreement on the ground of a material breach going
         to the root of this Agreement.

23.5     In the event of the Lessor having cancelled this Agreement justifiably
         but the Lessee remaining in occupation of the Premises, with or without
         disputing the cancellation, and continuing to tender payments of rent
         and any other amounts which would have been payable to the Lessor but
         for the cancellation, the Lessor may accept such payments without
         prejudice to and without affecting the cancellation, in all respects as
         if they had been payments on account of the damages suffered by the
         Lessor by reason of the unlawful holding-over on the part of the
         Lessee.

24.      OPTION OF RENEWAL:

24.1     The Lessee shall have the right to renew this Agreement upon the terms
         and subject to the conditions set out below.

24.2     The period for which this lease may be so renewed is five years,
         commencing on the date immediately following the date of expiry of the
         initial term of this lease.

24.3     All the terms of this Agreement shall continue to apply during the
         renewal period, save that:

         24.3.1   the rent shall be determined as set out in clause 6; and

         24.3.2   there shall be no further right of renewal.

LEASE(QUINTILES)                       23                        7 DECEMBER 1999

<PAGE>

24.4     The right of renewal shall be exercised by notice in writing from the
         Lessee to the Lessor given and received not later than 6 (six) months
         prior to the date on which the renewal period is to commence, and shall
         lapse if not so exercised.

24.5     If the right of renewal is duly exercised, this Agreement shall be
         renewed automatically and without the need for any further act of the
         parties.

24.6     The Lessee may not, however, exercise the right of renewal while in
         breach or default of any of the terms of this Agreement.

24.7     If this Agreement does not endure at least for the full term for which
         it is initially contracted, the right of renewal shall lapse and any
         notice of exercise thereof given prior to such lapsing shall be null
         and void.

27.      NEW TENANTS AND PURCHASERS:

         The Lessee shall at all reasonable times:

25.1     during the Lease Period, allow prospective purchasers of the Property
         or of any shares or other interests in the Lessor; and

25.2     during the last 6 (six) months of the Lease Period, allow prospective
         tenants or purchasers of the Premises, to enter and view the interior
         of the Premises.

27.      COSTS:

         Each party shall bear its own legal costs incurred in the preparation
         and negotiation of this lease provided that the stamp duty payable
         thereon shall be borne and paid by the Lessee.

27.      DOMICILIA AND NOTICES:

27.1     The parties choose as their domicilia citandi et executandi the
         addresses mentioned in clause 27.2, provided that such domicilium of
         either party may be changed by written notice from such party to the
         other party with effect from the date of receipt or deemed receipt by
         the latter of such notice.

LEASE(QUINTILES)                       24                        7 DECEMBER 1999

<PAGE>

27.2     The parties domicilia addresses:

         27.2.1   The Lessor:
                  The Centurion Wine Centre
                  123 Amkor Road
                  Lyttelton Manor X3
                  Centurion
                  0157

         27.2.2   The Lessee:

                  At the Premises

27.3     Any notice, acceptance, demand or other communication properly
         addressed by either party to the other party at the latter's domicilium
         in terms hereof for the time being and sent by prepaid registered post
         shall be deemed to be received by the latter on the 7th (seventh)
         business day following the date of posting thereof. This provision
         shall not be construed as precluding the utilisation of other means and
         methods (including telefacsimile) for the transmission or delivery of
         notices, acceptances, demands and other communications, but no
         presumption of delivery shall arise if any such other means or method
         is used.

28.      WHOLE AGREEMENT:

28.1     This is the entire agreement between the parties.

28.2     Neither party relies in entering into this agreement on any warranties,
         representations, disclosures or expressions of opinion which have not
         been incorporated into this agreement as warranties or undertakings.

28.3     No variation or consensual cancellation of this agreement shall be of
         any force or effect unless reduced to writing and signed by both
         parties.

29.      NON-WAIVER:

29.1     Neither party shall be regarded as having waived, or be precluded in
         any way from exercising, any right under or arising from this lease by
         reason of such party having at any time granted any extension of time
         for, or having shown any indulgence to, the other party with reference
         to any payment or performance hereunder, or having failed to enforce,
         or delayed in the enforcement of, any right of action

LEASE(QUINTILES)                       25                        7 DECEMBER 1999

<PAGE>

         against the other party.

29.2     The failure of either party to comply with any non-material provision
         of this lease shall not excuse the other party from performing the
         latter's obligations hereunder fully and timeously.

30.      WARRANTY OF AUTHORITY:

         The person signing this lease on behalf of the Lessee expressly
         warrants his authority to do so.

31.      SECURITY FOR PAYMENT BY LESSEE:

31       As security for the due performance by the Lessee of the Lessee's
         obligations in terms of this Agreement the Lessee shall provide the
         Lessor on the date of signature of this Agreement by the party last
         signing, with, at the choice of the Lessor, either or both:

         31.1.1        A signed suretyship binding the Lessee to the Lessor in
                       writing as surety and co-principal debtor for all the
                       obligations of the Lessee to the Lessor under this
                       Agreement as well as those arising in consequence of any
                       termination thereof; and/or

         31.1.2        an unconditional and irrevocable bank guarantee, in a
                       form and from an institution acceptable to the Lessor, of
                       the due payment by the Lessee of the rental or any other
                       amounts payable in terms of this agreement, provided that
                       the liability of the guarantor shall be limited to an
                       amount equal to four months rental, such rental to be the
                       rental applicable to the year in respect of which the
                       amount become owing, having taken all escalations into
                       account.

31.2     The provision of the security as set out in this clause shall act as a
         suspensive condition to this Agreement becoming operational except as
         set forth in this clause and unless provision of such security is
         waived by the Lessor in writing in terms of 31.3, this lease shall not
         come into operation but shall be null and void save that the Lessee
         shall then solely bear and pay, or reimburse the Lessor on demand with,
         the costs of this lease and the Lessor's expenses in reletting the
         Premises, including any agent's commission and advertising costs.

31.3     The Lessor, by his signature to this agreement, waives the provision of
         security as contemplated in 31.2. The parties however agree that

LEASE(QUINTILES)                       26                        7 DECEMBER 1999

<PAGE>

         the Lessor shall at any time during the Lease Period be entitled to
         call for such security in writing and the Lessee shall within 7 (Seven)
         days after receiving such notice provide the security called for
         failing which the Lessee shall be in breach of this agreement.

32.      SALE OF PREMISES

The validity of this lease shall not in any way be affected by the transfer of
the Property, Building or Premises from the Lessor pursuant to a sale thereof.
It shall accordingly, upon registration of transfer of the Property, Building or
Premises into the name of the purchaser, remain of full force and effect save
that the purchaser shall be substituted as lessor and acquire all rights and be
liable to fulfil all the obligations which the Lessor, as lessor, enjoyed
against or was liable to fulfil in favour of the Lessee in terms of this
Agreement.

DATED at CENTURION on 13 DECEMBER 1999.

AS WITNESSES:

1.   /s/ [illegible]
     -------------------------------------

                                             /s/ [illegible]
                                             ----------------------------------
                                             For and on behalf of Shibbolet
                                             (Proprietary) Limited

2.   /s/ [illegible]
     -------------------------------------

DATED at CENTURION on 13 DECEMBER 1999.

AS WITNESSES:

1.   /s/ [illegible]
     -------------------------------------

                                             /s/ [illegible]
                                             ----------------------------------
                                             For and on behalf of Quintiles
                                             Clindepharm (Proprietary) Limited

2.   /s/ [illegible]
     -------------------------------------

LEASE(QUINTILES)                       27                        7 DECEMBER 1999