## UNITED STA TE S ENVIRONMENTAL PROTECTION AGENCY

W ASIDNGTON, D.C. 20460

OFFICE OF C HEMI CAL SAFETY

AND POLLUTIO N PREVENTION



## MEMORANDUM

Date:

Subject:

From/To:

Through: 23-April-20 14

Flutriafol. Acute and Chronic Dietary Expos ure and Risk Assessment in Support of

Tolerances for Residues in/on Field Com, Popcorn

, Peanut, Wheat

, S trawberrie s, Cuc urbit Vegetables, Fruiting Vegetabl es
, and Tree N uts.

PC Code: 128940 DP Barcode s: 0417188

, 0417189

Decision Nos.: 475 6 94

, 478287 Registration Nos.: 67760-75 and 67760-120

Petition Nos.: 3F8156 and 3F8174 Regu la tory Action: Section 3 Registration s Risk Assessment Type: dietary Case No.: 7060

TXR No.: not applicable CAS No.: 76674-21-0

MRID N o: not appli c able 40 CFR: 18 0. 629



# , - ·**~** Tom Bloem, Chem i st · Risk Assessment

# Bran~ealth ects Dt i sion (RAB 1 / HED ; 7509P) "

, 

## David Hrd y, Senio r Biologist

, C hemistry an1

# EhW~urepr~J~EB)IHED**f1~zi (:fj** **)~** Thurston Morton, Chemist

, RAB4 / HED 

# 1f:..P'**~** 

# - · 0

Di etary Ex posure Science Advisory Committee (DESAC) Secondary Review

George F. Kramer

, Ph.D.

, Senior Chemist

RABl/HED (7509P)

Executive Summary

Based on the indentified r esidues of concern (ROC) and toxicological considerations, HED

determined that the following three dietary risk assessments are required when evaluating exposure

to flutriafol: (1) 

## T (1,2,4-triazole); (2) TA (triazolylalanine), TAA (t riazolylac e tic acid), and TLA (triazo l e lactic acid); and (3) flutriafol and the remaining ROC. The current document concerns dietary exposure to flutriafol and those metabolites found to be toxicologically simila r to flutriafol ( # 3 in the previous list). For information concerning the toxicity / exposure toT and TA/TAA/TLA,

see the human -hea l th risk assessment document D411 360 (T. Bloem 

## et al., 23-Apr-20 14 ).

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model- Food Consumption In take Database (DEEM -F CID, ver

. 3.16) which incorporates the food consumption data from the Uni ted States Department of Agriculture (US DA) National Health and Nu tri tion Exami nation Survey, What We

Eat in America (NHANES/WWEIA; 2003-2008). These analyses were conducted in s upp ort of the proposed tolerances for residues inion wheat

, strawberries

, cucurbit vegetables

, fruiting vegetables,

and tree nuts and the proposed label amendments for field com
, popcorn, and peanut ( D41 5068, T. 

## Bloem, 23-Apr-20 14 ).

Page I of23

### Flutriafol Dietary Exposure and Risk Assessment 

### 0417188



## T he acute and chronic analyses assumed to l erance -l evel residues or tolerance- l evel residues adj u sted to account for the ROC for risk assessment, 100% crop treated, and modeled drinking

water est i mates. Si n ce adequate processing stud i es have been submitted which indicate that

tolerances for residues inion app le juice, grape juice, dried prunes
, and tomato puree are

unnecessary and since tolerances for residues in/on raisins and tomato pas t e tolerances are

es t ab li shed/recommended, the DEEM (ver. 7.81) default p r ocess i ng factors for these

commodi ti es we r e reduced to 1. The DEEM (ver. 7.81) default processing fac t ors were retained

for the remain i ng relevant commodities. The resul t ing ac u te (:::;31% acu t e pop ul ation adjusted

dose (aPAD); females 1 3

- 49 yea r s occup i ed t he hi ghest% ofthe aPAD) and chronic (::;51%
cPAD; children (1-2 years old) had the highes t exposure) dietary risk estimates are not of

concern to HED.



## I. Introduction

Die t ary risk assessmen t incorporates both exposure and toxicity of a g i ven pest i c ide. For acute

and chron i c assessments, the risk is expressed as a percentage of a maximum acceptable dose
(i.e., the dose that H ED has concluded will result in no unreasonable adverse heal t h effects).

This dose is referred to as the p opulation -a djusted dose (PA D)

. T he PAD is equivalent to the point of departure (POD, no-observable adverse-effec t level (NOAEL), l owest

- obse r vable

adverse

- effect level ( L OAE L)

, e.g

. ) divided by th e required uncertainty or safe t y factors. For

acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds

100% of the PAD. References that discuss the acute and chron i c r isk assessme nt s in more detail

are available on the EP Npesticides web site: "Ava il able I nforma t ion on Assessing Exposure

from Pe s ticides

, A User's Guide, " 21-JUN-2000, web link: http://www.e p a.gov/fedrgstr/EPAPEST/2000/July/Day-12/606 1 .pdf; o r see SOP 99.6 (20-A u g-1999).

The most recen t dietary risk assessme nt for flutriafol was conducted by 

## T. Bloem (D407105, 27

- May-2013).



## II. Residue Information

ROC in Plants, Livestock, and Water: T able 1 is a summary of the ROC in primary crops, li vestock, r otat i onal crops, and wa t er (for further information see D415068 (T

. Bloem, 23-Apr2014). Based on the indentified ROC and toxicological considerations, HED determined that the

fo ll owi n g three dietary risk assessments are required whe n evaluating exposure to flutriafo l: (1)
T; (2) 

## TNT AA/T L A; and 

## (3) flutriafol and the remai n ing ROC. The current docum e nt concerns dietary expos ure to flutriafo l and those metabo li tes found to be toxicologically sim il ar to

flutriafol. For furt h er information concerning t h ese conclus i ons and for information concern in g
the toxicity/exposure to T a nd 

## T AfT ANTLA see t he human -h ea l th risk assessment document

D411360 (T. Bloem 

## et al., 23

- Apr

- 20 1 4)

.

Page 2 of23

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 3 of 23 Table 1: Summary of Metabolites and Degradates of Concern for Risk Assessment and Tolerance Enforcement.

Matrix R OC 1

Risk Assessment Tolerance Enforcement
coffee, soybean seed, fruit, sugar

beet

, cucurbit vegetables, fruiting vegetables, and tree nuts flutriafol, T, TA, and TAA

flutriafol (free) cotton (Section 18 use) 2 , peanut,
and cereal grains flutriafol (free and conjugated), defluorinated flutriafol, T, TA, and TAA ;

c ombined flutriafol (free and conjugated) and defluorinated flutriafol

residues may be estimate by multiplying the free flutriafol residues by

2.2 x 5

rotational crops (excluding dried roughage feed commodities) flutriafol (free and conjugated), M28, T, TA (free and conjugated), TAA,

and TLA ; combined flutriafol (free and conjugated) and M28 residue may be estimated by multiplying the free flutriafol residue by 1.3x 5

rotational crops (dried roughage feed commodities) same as that mentioned above but with multiplication of the free flutriafol residues by 2. 0 x to account for the combined residues of flutriafol (free and conjugated) and M28
poultry 3 flutriafol

, T, TA

, and TAA

ruminan t 4 flutriafol , M3, M3e, M4, M7, M10, T, TA

, and TAA ; combined flutriafol, M3, M3e, M4, M7, and M10 residues may be estimated by multiplying the free flutriafol residue by the following 5 : skim milk

- 58x, cream

- 15x,

liver, 5.3x, kidney 77x, muscle

- 6x, and fat

- 2x

water flutriafol and T

--
1 Separate risk assessments are required for T and TA/TAA/TLA; these compounds have been determined to be toxicologically

different from flutriafol.

2 Decision will be reevaluated if a Section 3 use is requested (additional data may be required).

3 HED notes that if the poultry dietary burdens increase, then these conclusions will be revisited and poultry metabolism studi es conducted as specified in OPPTS 860.1300 with [carbinol

14 C]flutriafol and [triazole

- 3,5

- 14 C]flutriafol may be required.

4 HE D notes that if the ruminant dietary burden increases, then these conclusions will be revisited and ruminant metabolism studies conducted as specified in OPPTS 860.1300 with [carbinol

14 C]flutriafol and [triazole

- 3,5

- 14 C]flutriafol may be required.

5 Th e indicated factors are based on results from the metabolism stud ies or confined rotational crop study.



## Residue Estimates for the Acute and Chronic Analyses: HED reviewed a Section 3 request for application of flutriafol to w heat, s trawberries, c ucurbit v egetables, f ruiting v egetables, and t ree

n uts and reviewed label amendments for field corn, popcorn, and peanut. Based on the available data, HED determined that the tolerances listed in Table 2 for residues of flutriafol per se are appropriate ( D 415068

, T. Bloem, 2 3

- Apr

- 201 4 )

. It is noted that the currently

- established field corn grain (0.01 ppm) , popcorn grain (0.01 ppm) , and peanut nutmeat (0.09 ppm) tolerances are considered adequate to cover the proposed label revisions.

Table 2: Summary of HED

- Recommended Tolerances.

Commodity HED

- Recommended Tolerance (ppm)

Strawberry 1.5

Wheat, forage 30

Wheat, hay 15

Wheat, straw 9.0

Wheat, grain 0.1 5

W heat, bran 0. 3 0

W heat, germ 0.25

Corn, field, forage 1 5.0

Corn, field, stover 1 15

Corn, pop, stover 1 15

Peanut, hay 15

Almond hull 15

Almond 0.60

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 4 of 23 Table 2: Summary of HED

- Recommended Tolerances.

Commodity HED

- Recommended Tolerance (ppm)

Pecan; African tree nut; Brazil nut; Bur oak; Butternut; Cajou; Cashew; Castanha

- do

maranhao; Coconut; Coquito nut; Dika nut; Guiana chestnut; Hazelnut; Heartnut; Hickory nut; Japanese horse

- chestnut; Macadamia nut; Mongongo nut; Monkey

- pot; Pachira nut; Sapucaia nut; balck walnut; English walnut 0.02

Vegetable, cucurbit, group 9 0.30

Vegetable, fruiting, group 8

- 10 1. 0

Tomato, paste 1.5

Hog, fat 0.01

Hog, muscle 0.01

Cattle, liver 0.80

Cattle, meat byproducts, except liver 0.05

Cattle, muscle 0.05

Cattle, fat 0.05

Goat, liver 0.80

Goat, meat byproducts, except liver 0.05

Goat, muscle 0.05

Goat, fat 0.05

Horse, liver 0.80

Horse, meat byproducts, except liver 0.05

Horse, muscle 0.05

Horse, fat 0.05

Sheep, liver 0.80

Sheep, meat byproducts, except liver 0.05

Sheep, muscle 0.05

Sheep, fat 0.05

Milk 0.01

1 The currently established field corn forage and stover tolerances and popcorn stover tolerances should be increased to the

indicated levels.



## Crop Residues: Based on the ROC for risk assessment, the dietary expo sure analyses assumed

tolerance

- level residues for all of crops excluding peanut, corn (field, sweet, and pop)

, wheat, and cotton; for these commodities and as indicated in Table 1, the tolerance was multiplied by 2.2x (peanut, field corn, popcorn, wheat, and cotton (seed and oil); prima ry crop tolerances) or 1.3x (sweet corn; rotational crop tolerance). Since adequate processing stud ies have been submitted

which indicate that tolerances for residues in/on apple juice , grape juice, dried prunes , and tomato

puree are unnecessary and since tolerances for residues in/on raisin s and tomato paste are

established/recommended

, the DEEM (ver

. 7.81) default processing factors for these commodities

were reduced to 1 (D340513, T. Bloem, 11

- Mar

- 2009; D388603, T. Bloem, 17

- Aug

- 2011 ;
D 415068 , T. Bloem, 2 3

- Apr

- 2014 ) . T he DEEM (ver

. 7.81) default processing factors were retained for the following commodities: dried apple (8.0x) , dried apricot (6.0x), dried banana (3.9x), high fructose corn syrup (1.5x), cherry juice (1.5x), dried peach (7.0x), peanut butter (1.89x), dried pears (6.25x), dried plantains (3.9x), prune juice (1.4x) , tomato juice (1.5x), and dried tomato (14.3x)

. See Table 2 for a summary of residues, adjustment factors, and processing factors used in the dietary analysis for the c rop commodities.

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 5 of 23 

## Poultry Residues: The poultry maximum reasonably

- balanced dietary burden (MRDB) for risk

assessment is 0.2 40 ppm with the bulk of this occupied by cottonseed meal ( 0.220 ppm; see Table

4 ; dietary burdens to flutriafol and the ROC ident ified as being toxicologically identical to flutriafol). Based on an adequate poultry feeding study and the current MRDB, residues of

flutriafol per se in poultry commodities are expected to be ≤0.00 5 ppm (see Table 5 ). HED concludes that inclusion of po ultry commodities in the risk assessment is unnecessary for the following reasons: (1) th e cottonseed meal Section 18 tolerance, which occupies the bulk of the poultry dietary burden, is based on soybean seed data form foliar application with the Section 18 application scenario calling for soil application at planting; therefore, the actual poultry dietary burden is likely to be significantly lower than that calculated here and (2) the poultry MRDB

assumed tolerances

- level residue s for the cotton commoditi es with the most recent guidance indicating that incorporation of median residues for the relevant cotton commodities is acceptable

.

Ruminant and Hog Residues: The beef cattle, dairy cattle, and hog MRDBs for risk assessment

are 37.372 ppm, 4.218 ppm, and 0.184 ppm, respectively (see Table 4 ; dietary burdens to

flutriafol and the ROC identified as being toxicologically identical to flutriafol). Table 5 presents a summary of an adequate ruminant feeding study and the estimated residues in ruminant commodities at the current MRDB. The residue estimate from the feeding level closet to the current MRDB was used in the assessment and is in bold in Table 5; if the MRDB falls between two of the feeding levels, then the feeding level with the highest est imate residue was used. For whole milk, residues were <LOQ at all the dosing levels and the transfer coefficients from the highest dosing level, assuming a LOQ residues, was used.

It is noted that the feeding study monitored for residues of only flutri afol with the ROC for risk

assessment estimate d using the factors listed in Table 1 ( factors derived from the metabolism study)

. The factors range from 2

- 77x and reflect the fact that parent was not the major residue in some of the matrices. However, HED concludes that the employed residue estimates are

conservative as they are comparable to, or significantly higher than, the TRRs from the metabolism study (30 ppm dietary burden) and due to the conservative nature of the dietary

burden calculations.

Fish: The USDA Pesticide Data Program (PDP) did not monitor for r esidues of flutriafol in fish

. The petitioner has submitted a fish bio accumulation study which yielded maximum bioconcentration factors ( BCF s), based on total radioactive residues (TRRs), of 6.8 x for whole

fish , 4.7 x for muscle tissue, and 12.2 x for viscera ( TRRs reached a plateau within the study exposure period ). The study included a 7

- day depuration period which indicated the following: (1) TRRs in whole fish decreased to 80% by day 1 and to 2% by day 7; (2) TRRs in muscle decreased to 3% by day 1; and (3) TRRs in viscera decreased to 31% by day 1 and to 3% by da y 7

.

Based on the maximum concentration in surface water of 0.0 4 1 ppm (see Section IV below) and

the 4.7x BCF for muscle, a residue in fish of 0. 193 ppm can be calculated. Assuming this residue for all fish/shellfish and conducting a dietary analysis with only fish/shellfish, exposures estimates

are ≤ 2.1 % the aPAD (acute estimates for consumers only; 95 th 

## percentile) and ≤0. 2 % the cPAD.

Based on th ese low risk estimates and the conservative nature of th e analysis (maximum water

concentration ; maximum BCF for muscle ; BCFs are based on TRRs ; the depuration data not considered), HED concludes that residues in fish are not a significant source of dietary exposure and do not need to be included in the analysis (this includes consumption at the subsistence level)

.

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 6 of 23 Table 3 : Summary of Tolerances, Adjustment Factors, Assessment Residue Level s, and Processing Factors

for the Crop and Livestock Commodities.

Commodity Tolerance

(ppm) Adjustment Factors

for Residues of Concern Assessment

Residue Level (ppm) Processing

Factor Percent Crop

Treated

b anana 0.3 0

-- 0.3 0 3.9

- dried 100

c offee , roasted bean 0.15

-- 0.15 1.0 100
coffee, instant 0. 30

-- 0.30 1.0 100

c ottonseed, oil 0.5 0 2.2 1.1 1.0 100

g rape 1.5

-- 1.5 1.0

- juice 100

g rape, raisin 2.4

-- 2.4 1.0 100

p eanut 0.09 2.2 0.198 1.89

- peanut butter 100

p lantain 0.3 0

-- 0.3 0 3.9

- dried 100

b eet, sugar 0.08

-- 0.08 1.0 100

s oybean 0.35

-- 0.35 1.0 100

p ome fruit 11

- 09 0.4 0

-- 0.4 0 1.0

- apple juice

8.0

- dried apple

6.25

- dried pear 100

s tone fruit 12

- 10 1.5

-- 1.5 6.0

- dried apricot

1.5

- cherry juice

7.0

- dried peach

1.0

- dried prune

1.4

- prune juice 100

c orn, field , grain 0.01 2.2 0.022 1.5

- syrup 100

c orn, field, oil 0. 0 2 2.2 0.044 1.0 100

c orn, pop 0.01 2.2 0.022 1.0 100

c orn, sweet 0.01 1.3 0.013 1.0 100

wheat grain 0.15 2.2 0.33 1.0 100

wheat bran 0.30 2.2 0.66 1.0 100 wheat germ 0.25 2.2 0.55 1.0 100 strawberry 1.5

-- 1.5 1.0 100 cucurbit vegetable 9 0.30

-- 0.30 1.0 100

fruiting vegetable 8

- 10 1. 0

-- 1. 0 1.0

- tomato puree
1.5

- tomato juice

14.3

- tomato dried 100

tomato paste 1.5

-- 1.5 1.0 100

almond 0.60

-- 0.60 1.0 100 pecan and the tree nuts

pecan represents 1 0.02

-- 0.02 1.0 100

1 

### See the following document dated 30

- Sep

- 2010: Crop Grouping

– Part IX: Analysis of the USDA IR

- 4 Petition to Amend the Crop Group Regulation 40 CFR § 180.41 (c) (16) and Commodity Definitions [ 40 CFR 180.1 (g)]

Related to the Crop Group 14 Tree Nuts. Part I. Analysis.

Table 4 : Calculation of Dietary Burdens of Flutriafol Residues to Livestock.

Feedstuff Type 1 % Dry Matter 2 % Diet 2 Residue (ppm) 1 Dietary Contribution (ppm) 3

Beef Cattle aspirated grain fractions CC 85 5 0.8 36 (M) 0.0 49

field corn grain CC 88 75 0.0 22 (M) 0.0 1 9
wheat hay R 88 15 23.98 (HAFT) 4.088

cotton meal PC 89 5 1.10 (T) 0.0 62

Total burden

-- -- 100

-- 4.218

Dairy Cattle wet apple pomace CC 40 10 0.115 (M) 0.029
field corn grain CC 88 35 0.0 22 (M) 0.0 09
wheat forage R 25 20 41.80 (HAFT) 33.44
field corn forage R 40 25 6.03 (HAFT) 3.77

cotton meal PC 89 10 1.10 (T) 0. 124

Total burden

-- -- 100

-- 37.372

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 7 of 23 Table 4 : Calculation of Dietary Burdens of Flutriafol Residues to Livestock.

Feedstuff Type 1 % Dry Matter 2 % Diet 2 Residue (ppm) 1 Dietary Contribution (ppm) 3

Poultry field corn grain CC 88 75 0.0 22 (M) 0.0 17

cotton meal PC 89 20 1.10 (T) 0. 220
soybean meal PC 89 5 0.05 (M) 0.003

Total burden

-- -- 100

-- 0.240

Hog field corn grain CC 88 85 0.0 22 (M) 0.0 1 9

cotton meal PC 89 15 1.10 (T) 0. 165

Total burden

-- -- 100

-- 0. 182

1 R: Roughage; CC: Carbohydrate concentrate; PC: Protein concentrate ; M = median; HAFT = highest

- average field

- trial; T = tolerance. The cotton and cereal grain residue estimates were multiplied by 2.2 to account for the ROC fo r risk assessment (see Table 1). Tolerances were assumed for cotton commodities as a Section 18 u se is registered and residue depicting the uses are not available (tolerance is assumed to be a worst

- case estimate).

2 OPPTS 860.1000 Table 1 Feedstuffs ( June 200 8 ).

3 D ietary c ontribution = tolerance ÷ % dry matter x % diet ( for poultry and hog % dry matter is not considered)

.



### T able 5: Summary of Residue Data from Dairy Cattle Feeding Study with Flutriafol

.

Matrix Feeding Level

(ppm) Maximum Flutriafol

Residue (ppm) Flutriafol

Residue:Feed

Ratio Anticipated ROC at 1x MRBD 2

Dairy Cattle (49059703.der) cattle hog

Whole m ilk 1 (Days 7, 10, 14, 17, 21, 24, 26, and 28) 5.0 not analyzed

-- -- --
16.0 <0.01 0.0006 0.153

--
50.0 <0.01 0.0002 0.049

--

Cream (Days 14 and 21) 5.0 not analyzed

-- -- --
16.0 <0.01 0.0006 0.040

--
50.0 0.0155 0.0003 0.020

--

Skim m ilk (Days 14 and 21) 5.0 not analzyed

-- -- --
16.0 <0.01 0.0006 0.153

--
50.0 <0.01 0.0002 0.049

--

Liver 5.0 0.444 0.0888 17.589 0.087

16.0 0.77 0 0.0481 9.532 0.047

50.0 1.95 0.0390 7.725 0.038

Kidney 5.0 <0.01 0.0020 5.755 0.0283

16.0 0.0156 0.0010 2.806 0.0138

50.0 0.153 0.0031 8.806 0.043

Muscle , round 5.0 <0.01 0.0020 0.448 0.0022

16.0 <0.01 0.0006 0.140 0.0007

50.0 0.0644 0.0013 0.289 0.0014

Muscle, loin 5.0 <0.01 0.0020 0.448 0.0022

16.0 <0.01 0.0006 0.140 0.0007

50.0 0.066 0 0.0013 0.296 0.0015

Fat , omental 5.0 <0.01 0.0020 0.149 0.0007

16.0 0.0203 0.0013 0.095 0.0005

50.0 0.336 0.0067 0.502 0.0025

Fat, renal 5.0 <0.01 0.0020 0.149 0.0007

16.0 0.0203 0.0013 0.095 0.0005

50.0 0.317 0.0063 0.474 0.0023

Fat, subcutaneous 5.0 <0.01 0.0020 0.149 0.0007

16.0 0.0214 0.0013 0.100 0.0005

50.0 0.105 0.0021 0.157 0.0008

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 8 of 23 T able 5: Summary of Residue Data from Dairy Cattle Feeding Study with Flutriafol

.

Matrix Feeding Level

(ppm) Maximum Flutriafol

Residue (ppm) Flutriafol

Residue:Feed

Ratio Anticipated ROC at 1x MRBD 2

Poultry (47510201.de1.doc) 3

egg 0.45 <0.01 0.022 2 0.005

1.34 not analyzed

-- -- 4.48 0.0448 0.010 0 0.002

muscle 0.45 <0.01 0.022 2 0.005

1.34 not analyzed

-- -- 4.48 <0.01 0.002 2 0.0005

fat 0.45 <0.01 0.022 2 0.005

1.34 not analyzed

-- -- 4.48 0.0717 0.016 0 0.004

liver 0.45 <0.01 0.022 2 0.005

1.34 not analyzed

-- -- 4.48 0.0978 0.02 18 0.005

1 Data are summarized for days after residues had reached a plateau.

2 Anticipated ROC at 1x MRDB = (flutriafol residue:feed ratio) x (MRDB) x (adjustment factor to account for ROC for risk assessment (see Table 1)). Residues in b old were used in the assessment.

3 Inclusion of residues in poultry commodities in the risk assessment was determined to be unnecessary; for rationale see text above.



## III. Percent Crop Treated Information

The acute and chronic analyses assumed 100% crop treated for all commodities.

I V

. Drinking Water Data

T able 5 is a summary of worst case flutriafol per se surface

- /ground

- water estimated drinking

water concentrations (EDWCs) when considering all pr o posed/registered uses ( EFED; D412882, J. Wolf, 29

- Oct

- 2013 )

. The bolded EDWCs from Table 5 were incorporated directly into the dietary exposure analysis via the water sources direct (all sources) and indirect (all sources)

commodities. The water models and their description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.

Table 5 : Maximum Flutriafol EDWCs.

Model Application Rate Concentration (ppb)

Groundwater ( PRZM

- GW 1 ) stone fruit ( 4 x 0.114 lbs ai/acre at 7 day intervals) acute 310 grape (6 x 0.081 lbs ai/acre at 14 day intervals) chronic 202

Surface water (FIRST 2 ) Apples (6 x 0.114 lbs ai/acre at 7 day intervals) 3 acute 4 0.55

chronic 4.03

1 Pesticide Root Zone Model

- Groundwater (PRZM

- GW)

. 2 FQPA Index Reservoir Screening Tool (FIRST ver. 1.1.1)

. 3 The initially proposed application rate for apple.

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 9 of 23 

## V

. DEEM

- FCID Program and Consumption Information

Flutriafol acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

- FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA (2003

- 2008). The data are based on the reported consumption of more than 20,000 indivi duals over

two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are re tained as individual consumption events. Based on analysis

of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subg roups: the general U.S. population, all infants (<1 year old), children 1

- 2,

children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each f ood/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This pro cedure is performed for each population subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposur es is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and no ted in the risk assessment.

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 10 of 23 

## V I

. Toxicological Information

Table 6 is a summar y of the toxicological doses and endpoints for flutriafol dietary exposure assessment; based on the toxicological database and residue assumptions, RAB1 concluded that the Food Quality Protection Act (FQPA) safety factor (SF) may be reduced to 1x. For a

c omplete discussion concerning these conclusions, see D 405792 ( T. Bloem et al.

, 27

- Mar

- 2013 )

.

Table 6 : Summary of Toxicological Doses and Endpoints for Flutriafol Dietary Exposure Assessment 1



### .
Exposure/

Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD, Level of

Concern for Risk

Assessment Study and Toxicological Effects

Acute Dietary (Females, 13

- 49 Years of Age) NOAEL =

7 .5 mg/kg /day UF A = 10 x

UF H = 10 x FQPA SF = 1 x a RfD =

0.0 7 5 mg/kg/day

aPAD =

0.0 7 5 mg/kg/day Developmental study

– rabbit ; LOAEL = 15 mg/kg, based

on decreased number of live fetuses, complete litter resorptions and increased post

- implantation loss.

Acute Dietary (General Population, Including Infants and Children) NOAEL =

250 mg/kg /day UF A = 10 x

UF H = 1 0x FQPA SF = 1 x a RfD =

2.5 mg/kg/day

aPAD =.

2

. 5 mg/kg/day Neurotoxicity screening battery

– rat ; LOAEL = 750

mg/kg, based on decreased body weight, body

- weight gain, absolute and relative food consumption, and clinical signs of toxicity in both sexes: dehydration, urine

- stained abdominal fur, ungroomed coat, ptosis, decreased motor activity, prostration, limp muscle tone, muscle flaccidity, hypothermia, hunched posture, impaired or lost righting reflex, scant feces; in males: red or tan perioral substance, chromodacryorrhea, chromorhinorrhea and labored breathing, and in females: piloerection and bradypnea.

Chronic Dietary ( All populations ) NOAEL =

5 mg/kg/day UF A = 10 x

UF H = 10 x FQPA SF = 1 x cRfD =

0.05 mg/kg/day

cPAD = 0.05 mg/kg/day Chronic toxicity

– dog ; LOAEL = 2 0 mg/kg/day, based on

adverse liver findings (increased liver weights, increased centrilobular hepatocyte lipid in the liver, and increases in alkaline phosphatase, albumin, and triglycerides),

increased adrenal cortical vacuolation of the zona fasciculata, and marked hemoside rin pigmentation in the liver and spleen in both sexes; mild anemia (characterized by decreased hemoglobin, hematocrit, and red blood cell count) in the males; and initial body

- weight losses, decreased cumulative body

- weight gains, and increased

adrenal we ights in the females

. Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on the carcinogenicity studies in rats and mice.

1 P oint of d eparture (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no

observed adverse

- effect level. LOAEL = lowest

- observed adverse

- effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies ). PAD = population

- adjusted dose (a = acute, c = chronic). RfD = reference dose (a = acute, c = chronic)

.

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 11 of 23 

## V I I

. Results/Discussion & Conclusions

The unrefined acute (≤ 31 % aPAD; females 13

- 49 years occupied the highest % of the aPAD) and chronic (≤ 51 % cPAD; children (1

- 2 years old) had the highest exposure) analyses resulted in

risk estimate s less than HED's level of concern.

Table 7 : Summary of the Acute and Chronic Dietary Exposure and Risk

.

Population aPAD

(mg/kg/day) Exposure

(mg/kg/day) 1 %aPAD 1 cPAD (mg/kg/day) Exposure

(mg/kg/day) %cPAD

General U.S. Population

2.5 0.0 2 7 487 1

. 1

0.05 0.0 0 8 896 1 8

All Infants (< 1 year old) 0.0 6 5 963 2

. 6 0.0 19 913 40

Children 1

- 2 years old 0.0 6 0251 2. 4 0.0 2 5382 5 1

Children 3

- 5 years old 0.0 4 6566 1

. 9 0.0 1 8434 3 7

Children 6

- 12 years old 0.0 29389 1

. 2 0.0 1 0 803 2 2

Youth 13

- 19 years old 0.0 20440 <1 0.0 0 6565 1 3

Adults 20

- 49 years old 0.0 22428 <1 0.00 7519 1 5

Adults 50

- 99 years old 0.0 20 955 <1 0.00 7621 1 5

Females 13

- 49 years old 0.07 5 0.0 2 3031 31 0.0 0 7469 1 5

1 95 th percentile (tier 1 analysis)



## V II I

. Characterization of Inputs/Outputs

The acute and chronic analysis could be refined through the incorporation of maximum or average field trial residues, residue monitoring data, percent crop treated estimates, and/or empirical processing factors. Refined analyses are not needed at this time since the risk estimates are below

HED’s LOC.

IX

. C onclusions

The acute and chronic analyses assumed tolerance

- level residues or tolerance

- level residues adjusted to account for the ROC for risk assessment, 100% crop treated, and modeled drinking water estimates. Since adequate processing studies have been submitted whi ch indicate that

tolerances for residues in/on apple juice, grape juice, and dried prunes are unnecessary and since

tolerances for residues in/on raisin s and tomato paste are established/recommended , the DEEM (ver

. 7.81) default processing factors for thes e commodities were reduced to 1. The DEEM (ver

. 7.81) default processing factors were retained for the remaining relevant commodities. The resulting acute (≤ 31 % acute population adjusted dose (aPAD); females 13

- 49 years occupied the highest % of the aPAD) and chronic (≤ 51 % cPAD; children (1

- 2 years old) had the highest exposure) exposure estimates are not of concern to HED.

Attachment 1 : DEEM

- FCID acute exposure estimates (all populations except females 13

- 49 years old)

Attachment 2 : DEEM

- FCID ac ute exposure estimates (females 13

- 49 years old)

Attachment 3 : DEEM

- FCID acute residue file (all populations except females 13

- 49 years old)

Attachment 4 : DEEM

- FCID acute residue file (females 13

- 49 years old)

Attachment 5 : DEEM

- FCID chronic exposure estimates (all populations)

Attachment 6 : DEEM

- FCID chronic residue file (all populations)

CC with all attachments: Tamue Gibson (RD; 7505P) T. Bloem:S10945:PY:(703)605

- 0217:7509P

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 12 of 23 

### Attachment 1: DEEM

- FCID acute exposure estimates (all populations except females 13

- 49 years old)

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for FLUTRIAFOL NHANES 2003

- 2008 2

- Day

Residue file: 128940A EXCEPT FEMALES 13

- 49.R08 Ad justment factor #2 NOT used. Analysis Date: 04

- 23

- 2014/07:13:23 Residue file dated: 04

- 23

- 2014/07:07:03 NOEL (Acute) = 250.000000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours

Run Comment: "FQPA SF 1x"

============================================ ===================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.027487 1.10 9095 0.045998 1.84 5435 0.079113 3.16 3160 Hispanic:

0.029893 1.20 8363 0.049554 1.98 5045 0.080325 3.21 3112

Non

- Hisp

- White:

0.027110 1.08 9221 0.044211 1.77 5654 0.077721 3.11 3216

Non

- Hisp

- Black:

0.026595 1.06 9400 0.049859 1.99 5014 0.096041 3.84 2603

Non

- Hisp

- Other:

0.029362 1.17 8514 0.048577 1.94 5146 0.071088 2.84 3516 Nursing Infants:

0.041099 1.64 6082 0.067661 2.71 3694 0.099497 3.98 2512

Non

- Nursing Infants:

0.072612 2.90 3442 0.099290 3.97 2517 0.136730 5.47 1828

Children 1

- 6:

0.053396 2.14 4681 0.076355 3.05 3274 0.113765 4.55 2197

Children 7

- 12:

0.027434 1.10 9112 0.038897 1.56 6427 0.055305 2.21 4520

Male 13

- 19:

0.019578 0.78 12769 0.029897 1.20 8362 0.045267 1.81 5522

Male 20+:

0.020760 0.83 12042 0.030481 1.22 8201 0.045546 1.82 5488

Seniors 55+:

0.020950 0.84 11933 0.029360 1.17 8515 0.044151 1.77 5662

All In fants:

0.065963 2.64 3789 0.094991 3.80 2631 0.136404 5.46 1832

Children 1

- 2:

0.060251 2.41 4149 0.091328 3.65 2737 0.141036 5.64 1772

Children 3

- 5:

0.046566 1.86 5368 0.068847 2.75 3631 0.092331 3.69 2707

Children 6

- 12:

0.029389 1.18 8506 0.043300 1.73 5773 0.068488 2.74 3650

Youth 13

- 19:

0.020440 0.82 12230 0.031168 1.25 8020 0.041940 1.68 5960

Adults 20

- 49:

0.022428 0.90 11146 0.032285 1.29 7743 0.046192 1.85 5412

Adults 50

- 99:

0.020955 0.84 11930 0.029910 1.20 8358 0.044715 1.79 5590

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 13 of 23 

## Attachment 2: DEEM

- FCID acut e exposure estimates (females 13

- 49 years old)

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for FLUTRIAFOL NHANES 2003

- 2008 2

- Day

Residue file: 128940A FEMALES 13

- 49.R08 Adjustment factor #2 NOT used. Analysis Date: 04

- 23

- 2014/07:14:48 Residue file dated: 04

- 23

- 2014/07:07:54 NOEL (Acute) = 7.500000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours

Run Comment: "FQPA SF 1x"

========================================= ======================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- --- ---- -------- ---------- ------- -------- ---------- ------- -------- Female 13+ PREG:

0.021939 29.25 341 0.037510 50.01 199 0.041201 54.93 182

Female 13

- 19/NP:

0.020992 27.99 357 0.032691 43.59 229 0.038142 50.86 196 Female 20+/NP:

0.022855 30.47 328 0.032326 43.10 232 0.045035 60.05 166

Female 13

- 50:

0.022938 30.58 326 0.032831 43.78 228 0.044775 59.70 167

Female 13

- 49:

0.023031 30.71 325 0.032892 43.86 228 0.044710 59.61 167

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 14 of 23 

## Attachment 3 : DEEM

- FCID acute residue file (except females 13

- 49 years old)

Filename: C: \ Users \ tbloem \ Documents \ work \ flutria fol \ 128940A EXCEPT FEMALES 13

- 49.R08

Chemical: flutriafol RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day RfD(Acute): 2.5 mg/kg bw/day NOEL(Acute): 250 mg/kg bw/day
Date created/last modified: 04

- 23

- 2014/07:07:03 Program ver. 3.16, 03

- 08

- d
Comment: FQPA SF 1x

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.080000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.080000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- babyfood 0.080000 1.000 1.000 0600347000 6 Soybean, seed 0.350000 1.000 1.000 0600349000 6 Soybean, soy milk 0.350000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.350000 1.000 1.000 0600350000 6 Soybean, oil 0.350000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.350000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.350000 1.000 1.000 0603348000 6C Soybean, flour 0.350000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.350000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.000000 1.000 1.000
0801376000 8A Tomato, paste 1.500000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 1.500000 1.000 1.000 0801377000 8A Tomato, puree 1.000000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 1.000000 1.000 1.000
0801378000 8A Tomato, dried 1.000000 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 1.000000 14.300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.00 0
0801380000 8A Tomato, Tree 1.000000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000

0802234000 8BC Okra 1.000000 1.000 1.000 0802270000 8B Peppe r, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0901075000 9A Cantaloupe 0.300000 1.000 1.000 0901187000 9A Honeydew melon 0.300000 1.000 1.000

0901399000 9A Watermelo n 0.300000 1.000 1.000 0901400000 9A Watermelon, juice 0.300000 1.000 1.000 0902021000 9B Balsam pear 0.300000 1.000 1.000 0902088000 9B Chayote, fruit 0.300000 1.000 1.000 0902102000 9B Chinese waxgourd 0.300000 1.000 1.000

0902135000 9B Cucumber 0.300000 1.000 1.000 0902308000 9B Pumpkin 0.300000 1.000 1.000 0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 0902356000 9B Squash, summer 0.300000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.300000 1.000 1.000 0902357000 9B Squash, winter 0.300000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.300000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.400000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.400000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.400000 1.000 1.000 1100009000 11 Apple, dried 0.400000 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.400000 8.000 1.00 0 1100010000 11 Apple, juice 0.400000 1.000 1.000 1100010001 11 Apple, juice

- babyfood 0.400000 1.000 1.000 1100011000 11 Apple, sauce 0.400000 1.000 1.000 1100011001 11 Apple , sauce

- babyfood 0.400000 1.000 1.000 1100129000 11 Crabapple 0.400000 1.000 1.000 1100173500 11 Goji berry 1.000000 1.000 1.000 1100210000 11 Loquat 0.400000 1.000 1.000

1100266000 11 Pear 0.400000 1.000 1.000

1100266001 11 Pear

- babyfood 0.400000 1.000 1.000
1100267000 11 Pear, dried 0.400000 6.250 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 15 of 23 1100268000 11 Pear, juice 0.400000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.400000 1.000 1.000
1100310000 11 Quince 0.400000 1.000 1.000 1201090000 12A Cherry 1.500000 1.000 1.000 1201090001 12A Cherry

- babyfood 1.500000 1.000 1.000 1201091000 12A Cherry, juice 1.500000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 1.500000 1.500 1.000 1202012000 12B Apricot 1.500000 1.000 1.000 1202012001 12B Apricot

- babyfood 1.500000 1.000 1.000 1202013000 12B Apricot, dried 1.500000 6.000 1.000 1202014000 12B Apricot, juice 1.500000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 1.500000 1.000 1.000

1202230000 12B Nectari ne 1.500000 1.000 1.000

1202260000 12B Peach 1.500000 1.000 1.000

1202260001 12B Peach

- babyfood 1.500000 1.000 1.000
1202261000 12B Peach, dried 1.500000 7.000 1.000
1202261001 12B Peach, dried

- babyfood 1.500000 7.000 1.000 1202262000 12B Peach, juice 1.500000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 1.500000 1.000 1.00 0

1203285000 12C Plum 1.500000 1.000 1.000

1203285001 12C Plum

- babyfood 1.500000 1.000 1.000 1203286000 12C Plum, prune, fresh 1.500000 1.000 1.000
1203286001 12C Plum, prune, fresh

- babyfood 1.500000 1.000 1.000 1203287000 12C Plum, prune, dried 1.500000 1.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 1.500000 1.000 1.000 1203288000 12C Plum, prune, juice 1.500000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 1.500000 1.400 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, juice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.000 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000

1307359000 13G Strawberr y 1.500000 1.000 1.000 1307360000 13G Strawberry, juice 1.500000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 1.500000 1.000 1.000

1400003000 14 Almond 0.600000 1.000 1.000

1400003001 14 Almond

- babyfood 0.600000 1.000 1.000
1400004000 14 Almond, oil 0.600000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.600000 1.000 1.000

1400059000 14 Brazil nut 0.020000 1.000 1.000

1400068000 14 Butternut 0.020000 1.000 1.000

1400081000 14 Cashew 0.020000 1.000 1.000

1400155000 14 Hazelnu t 0.020000 1.000 1.000
1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 1400185000 14 Hickory nut 0.020000 1.000 1.000

1400213000 14 Macadamia nut 0.020000 1.000 1.000

1400269000 14 Pecan 0.020000 1.000 1.000

1400391000 14 Walnut 0.020000 1.000 1.000
1500120000 15 Corn, field, flour 0.022000 1.000 1.00 0
1500120001 15 Corn, field, flour

- babyfood 0.022000 1.000 1.000
1500121000 15 Corn, field, meal 0.022000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.022000 1.000 1.000
1500122000 15 Corn, field, bran 0.022000 1.000 1.000
1500123000 15 Corn, field, starch 0.022000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.022000 1.000 1.000 1500124000 15 Corn, field, syrup 0.022000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.022000 1.500 1.000
1500125000 15 Corn, field, oil 0.044000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.044000 1.000 1.000 1500126000 15 Corn, pop 0.022000 1.000 1.000
1500127000 15 Corn, sweet 0.013000 1.000 1.000
1500127001 15 Corn, swe et

- babyfood 0.013000 1.000 1.000 1500401000 15 Wheat, grain 0.330000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.330000 1.000 1.000
1500402000 15 Wheat, flour 0.330000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.330000 1.000 1.000 1500403000 15 Wheat, germ 0.550000 1.000 1.000
1500404000 15 Wheat, bran 0.660000 1.000 1.000
2003114001 20C Coconut, oil

- babyfood 0.020000 1.000 1.000
2003128000 20C Cottonseed, oil 1.100000 1.000 1.000
2003128001 20C Cottonseed, oil

- babyfood 1.100000 1.000 1.000
3100044000 31 Beef, m eat 0.296000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.296000 1.000 1.000
3100045000 31 Beef, meat, dried 0.296000 1.920 1.000 3100046000 31 Beef, meat byproducts 9.532000 1.000 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 16 of 23 3100046001 31 Beef, meat byproducts

- babyfood 9.532000 1.000 1.000
3100047000 31 Beef, fat 0.502000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.502000 1.000 1.00 0 3100048000 31 Beef, kidney 8.806000 1.000 1.000
3100049000 31 Beef, liver 9.532000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 9.532000 1.000 1.000
3200169000 32 Goat, meat 0.296000 1.000 1.000 3200170000 32 Goat, meat byproducts 9.532000 1.000 1.000
3200171000 32 Goat, fat 0.502000 1.000 1.000 3200172000 32 Goat, kidney 8.806000 1.000 1.000
3200173000 32 Goat, liver 9.532000 1.000 1.000
3300189000 33 Horse, meat 0.296000 1.000 1.000
3400290000 34 Pork, meat 0.002200 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.002200 1.000 1.000
3400291000 34 Pork, skin 0.087000 1.000 1.000
3400292000 34 Pork, mea t byproducts 0.087000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.087000 1.000 1.000
3400293000 34 Pork, fat 0.000700 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.000700 1.000 1.000 3400294000 34 Pork, kidney 0.028300 1.000 1.000
3400295000 34 Pork, liver 0.087000 1.000 1.000 3500339000 35 Sheep, meat 0.296000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.296000 1.000 1.000 3500340000 35 Sheep, meat byproducts 9.532000 1.000 1.000 3500341000 35 Sheep, fat 0.502000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.502000 1.000 1.000 3500342000 35 Sheep, kidney 8.806000 1.000 1.000 3500343000 35 Sheep, liver 9.532000 1.000 1.000
3600222000 36 Milk, fat 0.049000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.049000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.049000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.049000 1.000 1.00 0
3600224000 36 Milk, water 0.049000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.049000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.049000 1.000 1.000

8601000000 86A Water , direct, all sources 0.310000 1.000 1.000
8602000000 86B Water, indirect, all sources 0.310000 1.000 1.000

9500023000 O Banana 0.300000 1.000 1.000

9500023001 O Banana

- babyfood 0.300000 1.000 1.000
9500024000 O Banana, dried 0.300000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.300000 3.900 1.000
9500111000 O Coconut, meat 0.020000 1.000 1.000
9500111001 O Coconut, meat

- babyfood 0.020000 1.000 1.000
9500112000 O Coconut, dried 0.020000 1.000 1.000
9500113000 O Coconut, milk 0.020000 1.000 1.000
9500114000 O Coconut, oil 0.020000 1.000 1.000
9500115000 O Coffee, roasted bean 0.150000 1.000 1.000
9500116000 O Coffee, instant 0.300000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape, raisin 2.400000 1.000 1.000

9500263000 O Peanut 0.198000 1.000 1.000
9500264000 O Peanut, butter 0.198000 1.890 1.000
9500265000 O Peanut, oil 0.198000 1.000 1.000

9500283000 O Plantain 0.300000 1.000 1.000

9500284000 O Plantai n, dried 0.300000 3.900 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 17 of 23 

## Attachment 4 : DEEM

- FCID acute residue file (females 13

- 49 years old)

Filename: C: \ Users \ tbloem \ Documents \ work \ flutriafol \ 128940A FEMALES 13

- 49.R08

Chemical: flutriafol RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day RfD(Acute): .075 mg/kg bw/day NOEL(Acute): 7.5 mg/kg bw/day
Date created/last modified: 04

- 23

- 2014/07:07:54 Program ver. 3.16, 03

- 08

- d
Comment: FQPA SF 1x

------------------------------------------------------- ---------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.080000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.080000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000

010105300 1 1A Beet, sugar, molasses

- babyfood 0.080000 1.000 1.000 0600347000 6 Soybean, seed 0.350000 1.000 1.000 0600349000 6 Soybean, soy milk 0.350000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.350000 1.000 1.000 0600350000 6 Soybean, oil 0.350000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.350000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.350000 1.000 1.000 0603348000 6C Soybean, flour 0.350000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.350000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375 000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.000000 1.000 1.000 0801376000 8A Tomato, paste 1.500000 1.000 1.000 0801376001 8A Tomato, paste

- ba byfood 1.500000 1.000 1.000 0801377000 8A Tomato, puree 1.000000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 1.000000 1.000 1.000
0801378000 8A Tomato, dried 1.0000 00 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 1.000000 14.300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.000
0801380000 8A Tomato, Tree 1.000000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000

0802234000 8BC Okra 1.000000 1.000 1.000 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, b ell

- babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0901075000 9A Cantaloupe 0.300000 1.000 1.000 0901187000 9A Honeydew melon 0.300000 1.000 1.000

0901399000 9A Watermelon 0.300000 1.000 1.000 0901400000 9A Watermelon, juice 0.300000 1.000 1.000

0902021000 9B Balsam pear 0.300000 1.000 1.000 0902088000 9B Chayote, fruit 0.300000 1.000 1.000 0902102000 9B Chinese waxgourd 0.300000 1.000 1.000

0902135000 9B Cucumber 0.300000 1.000 1.000 0902308000 9B Pumpkin 0.300000 1.000 1.000 0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 0902356000 9B Squash, summer 0.300000 1.000 1.00 0 0902356001 9B Squash, summer

- babyfood 0.300000 1.000 1.000 0902357000 9B Squash, winter 0.300000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.300000 1.000 1.000 1100007000 11 Apple , fruit with peel 0.400000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.400000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.400000 1.000 1.000 1100009000 11 Apple, dried 0.400000 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.400000 8.000 1.000 1100010000 11 Apple, juice 0.400000 1.000 1.000 1100010001 11 Apple, juice

- babyfood 0.400000 1.000 1.000 1100011000 11 Apple, sauce 0.400000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.400000 1.000 1.000 1100129000 11 Crabapple 0.400000 1.000 1.000 1100173500 11 Goji berry 1.000000 1.000 1.000 1100210000 11 Loquat 0.400000 1.000 1.000

1100266000 11 Pear 0.400000 1.000 1.000

1100266001 11 Pear

- babyfood 0.400000 1.000 1.000
1100267000 11 Pear, dried 0.400000 6.250 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 18 of 23 1100268000 11 Pear, juice 0.400000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.400000 1.000 1.000
1100310000 11 Quince 0.400000 1.000 1.000 1201090000 12A Cherry 1.500000 1.000 1.000 1201090001 12A Cherry

- babyfood 1.500000 1.000 1.000 1201091000 12A Cherry, juice 1.500000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 1.500000 1.500 1.000 1202012000 12B Apricot 1.500000 1.000 1.000 1202012001 12B Apricot

- babyfood 1.500000 1.000 1.000 1202013000 12B Apricot, dried 1.500000 6.000 1.000 1202014000 12B Apricot, juice 1.500000 1.000 1.00 0 1202014001 12B Apricot, juice

- babyfood 1.500000 1.000 1.000

1202230000 12B Nectarine 1.500000 1.000 1.000

1202260000 12B Peach 1.500000 1.000 1.000

1202260001 12B Peach

- babyfood 1.500000 1.000 1.000
1202261000 12B Peach, dried 1.500000 7.000 1.000
1202261001 12B Peach, dried

- babyfood 1.500000 7.000 1.000 1202262000 12B Peach, juice 1.500000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 1.500000 1.000 1.000

1203285000 12C Plum 1.500000 1.000 1.000

1203285001 12C Plum

- babyfood 1.500000 1.000 1.000 1203286000 12C Plum, prune, fresh 1.500000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 1.500000 1.000 1.000 1203287000 12C Plum, pru ne, dried 1.500000 1.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 1.500000 1.000 1.000 1203288000 12C Plum, prune, juice 1.500000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 1.500000 1.400 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, juice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.000 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 1307359000 13G Strawberry 1.500000 1.000 1.000 1307360000 13G Strawberry, juice 1.500000 1.000 1.000

1307360001 13G Strawbe rry, juice

- babyfood 1.500000 1.000 1.000

1400003000 14 Almond 0.600000 1.000 1.000

1400003001 14 Almond

- babyfood 0.600000 1.000 1.000
1400004000 14 Almond, oil 0.600000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.600000 1.000 1.000

1400059000 14 Brazil nut 0.020000 1.000 1.000

1400068000 14 Butternut 0.020000 1.000 1.00 0

1400081000 14 Cashew 0.020000 1.000 1.000

1400155000 14 Hazelnut 0.020000 1.000 1.000
1400156000 14 Hazelnut, oil 0.020000 1.000 1.000

1400185000 14 Hicko ry nut 0.020000 1.000 1.000

1400213000 14 Macadamia nut 0.020000 1.000 1.000

1400269000 14 Pecan 0.020000 1.000 1.000

1400391000 14 Walnut 0.020000 1.000 1.000
1500120000 15 Corn, field, flour 0.022000 1.000 1.000
1500120001 15 Corn, field, flour

- babyfood 0.022000 1.000 1.000
1500121000 15 Corn, field, meal 0.022000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.022000 1.000 1.000
1500122000 15 Corn, field, bran 0.022000 1.000 1.000
1500123000 15 Corn, fie ld, starch 0.022000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.022000 1.000 1.000 1500124000 15 Corn, field, syrup 0.022000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.022000 1.500 1.000
1500125000 15 Corn, field, oil 0.044000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.044000 1.000 1.000 1500126000 15 Corn, pop 0.022000 1.000 1.000
1500127000 15 Corn, sweet 0.013000 1.000 1.000
1500127001 15 Corn, sweet

- babyfood 0.013000 1.000 1.000 1500401000 15 Wheat, grain 0.330000 1.000 1.000
1500401001 15 Wheat, grain

- babyfood 0.330000 1.000 1.000
1500402000 15 Wheat, flour 0.330000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.330000 1.000 1.000 1500403000 15 Wheat, germ 0.550000 1.000 1.000
1500404000 15 Wheat, bran 0.660000 1.000 1.000
2003114001 20C Coconut, oil

- babyfood 0.020000 1.000 1.000
2003128000 20C Cottonseed, oil 1.100000 1.000 1.00 0
2003128001 20C Cottonseed, oil

- babyfood 1.100000 1.000 1.000
3100044000 31 Beef, meat 0.296000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.296000 1.000 1.000
3100045000 31 Beef, meat, dried 0.296000 1.920 1.000 3100046000 31 Beef, meat byproducts 9.532000 1.000 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 19 of 23 3100046001 31 Beef, meat byproducts

- babyfood 9.532000 1.000 1.000
3100047000 31 Beef, fat 0.502000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.502000 1.000 1.000 3100048000 31 Beef, kidney 8.806000 1.000 1.000
3100049000 31 Beef, liver 9.532000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 9.532000 1.000 1.000
3200169000 32 Goat, meat 0.296000 1.000 1.000
3200170000 32 Goat, mea t byproducts 9.532000 1.000 1.000
3200171000 32 Goat, fat 0.502000 1.000 1.000 3200172000 32 Goat, kidney 8.806000 1.000 1.000
3200173000 32 Goat, liver 9.532000 1.000 1.000
3300189000 33 Horse, meat 0.296000 1.000 1.000
3400290000 34 Pork, meat 0.002200 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.002200 1.000 1.000
3400291000 34 Pork, skin 0.087000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.087000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.087000 1.000 1.000
3400293000 34 Pork, f at 0.000700 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.000700 1.000 1.000 3400294000 34 Pork, kidney 0.028300 1.000 1.000
3400295000 34 Pork, liver 0.087000 1.000 1.000 3500339000 35 Sheep, meat 0.296000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.296000 1.000 1.000 3500340000 35 Sheep, meat byproducts 9.532000 1.000 1.00 0 3500341000 35 Sheep, fat 0.502000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.502000 1.000 1.000 3500342000 35 Sheep, kidney 8.806000 1.000 1.000 3500343000 35 Sheep , liver 9.532000 1.000 1.000
3600222000 36 Milk, fat 0.049000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.049000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.049000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.049000 1.000 1.000
3600224000 36 Milk, water 0.049000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.049000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.049000 1.000 1.000
8601000000 86A Water, direct, all sources 0.310000 1.000 1.000
8602000000 86B Water, in direct, all sources 0.310000 1.000 1.000

9500023000 O Banana 0.300000 1.000 1.000

9500023001 O Banana

- babyfood 0.300000 1.000 1.000
9500024000 O Banana, dried 0.300000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.300000 3.900 1.000
9500111000 O Coconut, meat 0.020000 1.000 1.000
9500111001 O Coconut, meat

- babyfood 0.020000 1.000 1.000
9500112000 O Coconut, dried 0.020000 1.000 1.000
9500113000 O Coconut, milk 0.020000 1.000 1.000
9500114000 O Coconut, oil 0.020000 1.000 1.000
9500115000 O Coffee, roasted bean 0.150000 1.000 1.000
9500116000 O Coffee, instant 0.300000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape, raisin 2.400000 1.000 1.000

9500263000 O Peanut 0.198000 1.000 1.000
9500264000 O Peanut, butter 0.198000 1.890 1.000
9500265000 O Peanut, oil 0.198000 1.000 1.00 0

9500283000 O Plantain 0.300000 1.000 1.000
9500284000 O Plantain, dried 0.300000 3.900 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 20 of 23 

### Attachment 5: DEEM

- FCID chronic exposure estimates (all populations)

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for FLUTRIAFOL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ tbloem \ Documents \ work \ flutriafol \ field corn and popcorn

reduced PHI; new use for tree nut, strawberry, fruiting vegetable, and cucurbit
vegetable \ 128940C.R08 Adjustment factor #2 NOT used. Analysis Date 04

- 23

- 2014/07:15:25 Residue file dated: 04

- 23

- 2014/07:08:47

Reference dose (RfD, Chron ic) = .05 mg/kg bw/day

COMMENT 1: FQPA SF 1x

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------- ------

Total Exposure

----------------------------------- Population mg/kg Percent of
Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.008896 17.8% Hispanic 0.009248 18.5%

Non

- Hisp

- White 0.008976 18.0%

Non

- Hisp

- Black 0.007781 15.6%

Non

- Hisp

- Other 0.009560 19.1% Nursing Infants 0.008881 17.8%

Non

- Nursing Infants 0.024840 49.7%

Female 13+ PREG 0.007749 15.5%

Children 1

- 6 0.020477 41.0%

Children 7

- 12 0.009913 19.8%

Male 13

- 19 0.006552 13.1%

Female 13

- 19/NP 0.006582 13.2%

Ma le 20+ 0.007306 14.6%
Female 20+/NP 0.007786 15.6%

Seniors 55+ 0.007633 15.3%

All Infants 0.019913 39.8%

Female 13

- 50 0.007464 14.9%

Children 1

- 2 0.025382 50.8%

Children 3

- 5 0.018434 36 .9%

Children 6

- 12 0.010803 21.6%

Youth 13

- 19 0.006565 13.1%

Adults 20

- 49 0.007519 15.0%

Adults 50

- 99 0.007621 15.2%

Female 13

- 49 0.007469 14.9%

-------------------------------------------------------------------------------

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 21 of 23 

### Attachment 6: DEEM

- FCID chronic residue file ( all populations )

Filename: C: \ Users \ tbloem \ Documents \ work \ flutriafol \ field corn and popcorn reduced PHI; new use for tree nut, strawberry, fruiting vegetable, and cucurbit vegetable \ 128940C.R08

Chemical: flutriafol RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic ): 5 mg/kg bw/day RfD(Acute): 2.5 mg/kg bw/day NOEL(Acute): 250 mg/kg bw/day
Date created/last modified: 04

- 23

- 2014/07:08:47 Program ver. 3.16, 03

- 08

- d
Comment: FQPA SF 1x

---------------------------------------------------------------------------- ------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 01010 52000 1A Beet, sugar 0.080000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.080000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 0101053001 1A Beet, sugar, m olasses

- babyfood 0.080000 1.000 1.000 0600347000 6 Soybean, seed 0.350000 1.000 1.000 0600349000 6 Soybean, soy milk 0.350000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.35 0000 1.000 1.000 0600350000 6 Soybean, oil 0.350000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.350000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.350000 1.000 1.000

060 3348000 6C Soybean, flour 0.350000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.350000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.000000 1.000 1.000 0801376000 8A Tomato, paste 1.500000 1.000 1.000 0801376001 8A Tomato, p aste

- babyfood 1.500000 1.000 1.000 0801377000 8A Tomato, puree 1.000000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 1.000000 1.000 1.000
0801378000 8A Tomato, dried 1.000000 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 1.000000 14.300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.000
0801380000 8A Tomato, Tree 1.000000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000

0802234000 8BC Okra 1.000000 1.000 1.000 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0901075000 9A Cantaloupe 0.300000 1.000 1.00 0 0901187000 9A Honeydew melon 0.300000 1.000 1.000

0901399000 9A Watermelon 0.300000 1.000 1.000 0901400000 9A Watermelon, juice 0.300000 1.000 1.000

0902021000 9B Balsa m pear 0.300000 1.000 1.000 0902088000 9B Chayote, fruit 0.300000 1.000 1.000 0902102000 9B Chinese waxgourd 0.300000 1.000 1.000

0902135000 9B Cucumber 0.300000 1.000 1.000 0902308000 9B Pumpkin 0.300000 1.000 1.000 0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 0902356000 9B Squash, summer 0.300000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.300000 1.000 1.000 0902357000 9B Squash, winter 0.300000 1.000 1.000 0902357001 9B Squash, w inter

- babyfood 0.300000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.400000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.400000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.400000 1.000 1.000 1100009000 11 Apple, dried 0.400000 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.400000 8.000 1.000 1100010000 11 Apple, juice 0.400000 1.000 1.000 1100010001 11 Apple, juice

- babyfood 0.400000 1.000 1.000 1100011000 11 Apple, sauce 0.400000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.400000 1.000 1.000 1100129000 11 Crabapp le 0.400000 1.000 1.000 1100173500 11 Goji berry 1.000000 1.000 1.000 1100210000 11 Loquat 0.400000 1.000 1.000

1100266000 11 Pear 0.400000 1.000 1.000

1100266001 11 Pear

- babyfood 0.400000 1.000 1.000
1100267000 11 Pear, dried 0.400000 6.250 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 22 of 23 1100268000 11 Pear, juice 0.400000 1.000 1.00 0 1100268001 11 Pear, juice

- babyfood 0.400000 1.000 1.000
1100310000 11 Quince 0.400000 1.000 1.000 1201090000 12A Cherry 1.500000 1.000 1.000

1201090001 12A Cherr y

- babyfood 1.500000 1.000 1.000 1201091000 12A Cherry, juice 1.500000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 1.500000 1.500 1.000 1202012000 12B Apricot 1.500000 1.000 1.000 1202012001 12B Apricot

- babyfood 1.500000 1.000 1.000 1202013000 12B Apricot, dried 1.500000 6.000 1.000 1202014000 12B Apricot, juice 1.500000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 1.500000 1.000 1.000

1202230000 12B Nectarine 1.500000 1.000 1.000

1202260000 12B Peach 1.500000 1.000 1.000

1202260001 12B Peach

- babyfood 1.500000 1.000 1.000
1202261000 12B Peach, dried 1.500000 7.000 1.000
1202261001 12B Peach, dried

- babyfood 1.500000 7.000 1.000 1202262000 12B Peach, juice 1.500000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 1.500000 1.000 1.000

1203285000 12C Plum 1.500000 1.000 1.000

1203285001 12C Plum

- babyfood 1.500000 1.000 1.000 1203286000 12C Plum, prune, fresh 1.500000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 1.500000 1.000 1.000 1203287000 12C Plum, p rune, dried 1.500000 1.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 1.500000 1.000 1.000 1203288000 12C Plum, prune, juice 1.500000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 1.500000 1.400 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, juice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.00 0 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 1307359000 13G Strawberry 1.500000 1.000 1.000 1307360000 13G Strawberry, juice 1.500000 1.000 1.000

1307360001 13G Straw berry, juice

- babyfood 1.500000 1.000 1.000

1400003000 14 Almond 0.600000 1.000 1.000

1400003001 14 Almond

- babyfood 0.600000 1.000 1.000
1400004000 14 Almond, oil 0.600000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.600000 1.000 1.000

1400059000 14 Brazil nut 0.020000 1.000 1.000

1400068000 14 Butternut 0.020000 1.000 1.000

1400081000 14 Cashew 0.020000 1.000 1.000

1400155000 14 Hazelnut 0.020000 1.000 1.000
1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 1400185000 14 Hickory nut 0.020000 1.000 1.000

1400213000 14 Macadamia nut 0.020000 1.000 1.000

1400269000 14 Pecan 0.020000 1.000 1.000

1400391000 14 Walnut 0.020000 1.000 1.000
1500120000 15 Corn, field, flour 0.022000 1.000 1.000
1500120001 15 Corn, field, flour

- babyfood 0.022000 1.000 1.000
1500121000 15 Corn, field, meal 0.022000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.022000 1.000 1.000
1500122000 15 Corn, field, bran 0.022000 1.000 1.000
1500123000 15 Corn, f ield, starch 0.022000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.022000 1.000 1.000 1500124000 15 Corn, field, syrup 0.022000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.022000 1.500 1.000
1500125000 15 Corn, field, oil 0.044000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.044000 1.000 1.000 1500126000 15 Corn, pop 0.022000 1.000 1.00 0
1500127000 15 Corn, sweet 0.013000 1.000 1.000
1500127001 15 Corn, sweet

- babyfood 0.013000 1.000 1.000 1500401000 15 Wheat, grain 0.330000 1.000 1.000

1500401001 15 Wheat , grain

- babyfood 0.330000 1.000 1.000
1500402000 15 Wheat, flour 0.330000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.330000 1.000 1.000 1500403000 15 Wheat, germ 0.550000 1.000 1.000
1500404000 15 Wheat, bran 0.660000 1.000 1.000
2003114001 20C Coconut, oil

- babyfood 0.020000 1.000 1.000
2003128000 20C Cottonseed, oil 1.100000 1.000 1.000
2003128001 20C Cottonseed, oil

- babyfood 1.100000 1.000 1.000
3100044000 31 Beef, meat 0.296000 1.000 1.000
3100044001 31 Beef, mea t

- babyfood 0.296000 1.000 1.000
3100045000 31 Beef, meat, dried 0.296000 1.920 1.000 3100046000 31 Beef, meat byproducts 9.532000 1.000 1.000

### Flutriafol Dietary Exposure and Risk Assessment D417188

Page 23 of 23 3100046001 31 Beef, meat byproducts

- babyfood 9.532000 1.000 1.000
3100047000 31 Beef, fat 0.502000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.502000 1.000 1.000 3100048000 31 Beef, kidney 8.806000 1.000 1.000
3100049000 31 Beef, liver 9.532000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 9.532000 1.000 1.000
3200169000 32 Goat, meat 0.296000 1.000 1.000
3200170000 32 Goat, m eat byproducts 9.532000 1.000 1.000
3200171000 32 Goat, fat 0.502000 1.000 1.000 3200172000 32 Goat, kidney 8.806000 1.000 1.000
3200173000 32 Goat, liver 9.532000 1.000 1.000
3300189000 33 Horse, meat 0.296000 1.000 1.000
3400290000 34 Pork, meat 0.002200 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.002200 1.000 1.00 0
3400291000 34 Pork, skin 0.087000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.087000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.087000 1.000 1.000
3400293000 34 Pork, fat 0.000700 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.000700 1.000 1.000 3400294000 34 Pork, kidney 0.028300 1.000 1.000
3400295000 34 Pork, liver 0.087000 1.000 1.000 3500339000 35 Sheep, meat 0.296000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.296000 1.000 1.000 3500340000 35 Sheep, meat byproducts 9.532000 1.000 1.000 3500341000 35 Sheep, fat 0.502000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.502000 1.000 1.000 3500342000 35 Sheep, ki dney 8.806000 1.000 1.000 3500343000 35 Sheep, liver 9.532000 1.000 1.000
3600222000 36 Milk, fat 0.049000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.049000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.049000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.049000 1.000 1.000
3600224000 36 Milk, water 0.049000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.049000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.049000 1.000 1.000
8601000000 86A Water, direct, all sources 0.202000 1.000 1.000
8602000000 86B Water, indirect, all sources 0.202000 1.000 1.000

9500023000 O Banana 0.300000 1.000 1.000

9500023001 O Banana

- babyfood 0.300000 1.000 1.000
9500024000 O Banana, dried 0.300000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.300000 3.900 1.000
9500111000 O Coconut, meat 0.020000 1.000 1.000
9500111001 O Coconut, meat

- babyfood 0.020000 1.000 1.00 0
9500112000 O Coconut, dried 0.020000 1.000 1.000
9500113000 O Coconut, milk 0.020000 1.000 1.000
9500114000 O Coconut, oil 0.020000 1.000 1.000

9500115000 O Coffe e, roasted bean 0.150000 1.000 1.000
9500116000 O Coffee, instant 0.300000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape, raisin 2.400000 1.000 1.000

9500263000 O Peanut 0.198000 1.000 1.000
9500264000 O Peanut, butter 0.198000 1.890 1.000
9500265000 O Peanut, oil 0.198000 1.000 1.000

9500283000 O Plantain 0.300000 1.000 1.000
9500284000 O Plantain, dried 0.300000 3.900 1.000