Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

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### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

**WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND**  **POLLUTION PREVENTION**  

### MEMORANDUM Date: 2 5 - October - 2011 Subject: **Quizalofop -**  **P -**  **ethyl** . Revised Chronic Dietary Exposure Assessment to Support Section 3 Registration for use on Corn , Rapeseed and S o rghum . PC Code s : 128709,128711 DP Barcode: D 39 5387 Decision No.: 441518 Registration No.: 352 - 341 Petition No.: Regulatory Action: Amended Section 3 Risk Assessment Ty

pe: Dietary

Exposure Case No.: TXR No.: NA CAS No s .: 76578 - 14 - 8, 100646 - 51 - 3 MRID No.: NA 40 CFR: 180.441 REVIEWER: Seyed Tadayon, Chemist

Risk Assessment Branch V Health Effects Division (7509P) THROUGH: Donna Davis , Chemist

Meheret Negussie , Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509P) TO: Id eliz Negrón - Encarnación, PhD, Risk Assessor

Risk Assessment Branch V Health Effects Division (7509P) **Executive Summary** This is a revision of the original Chronic Dietary Exposure Assessment to Support Section 3 Registration for use on Corn, Rapeseed and Sorghum (S. Tadayon, August 24, 2011, Dp 393220 ). This assessment has been revised to address the change in tolerance value (rapeseed subgroup 20 A , E xcept flaxseed) from 1.00 ppm to 1.5 ppm. C hronic dietary

exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model (DEEM - FCIDTM, Version 2.03) which uses food consumption data from the U.S. Department of Agriculture’s Continuing Survey s of Food Intakes by Individuals (CSFII) from 1994 - 1996 and 1998. Acute dietary a ssessment was not conducted since there were no appropriate endpoints/doses selected for acute dietary risk assessment . The anal ys es were performed as part of a registration action; to support a Section 3 Registration on corn, rapesee d and sorghum. Quizalofop - p - eth yl was classified as "not likely " to be a human carcinogen , therefore no cancer assessment was performed.Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

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### The chronic anal ys is incorporated tolerance level residues for all commodities, and 100 percent crop treated (%CT) was assumed. DEEMTM (ver 7.78) default processing factors were assumed when applicable. The analy ses also included the PRZM - EXAMs modeled chronic surface water point estimate generated based on the sorghum application scenario. The chronic exposure estimates are  29 % cPAD and are therefore below HED’s level of concern (children 1 - 2 years old were the most highly

exposed population). **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For chronic assess ments, the risk is expressed as a percentage of a maximum acceptable dose. This is the PAD, which HED has concluded will result in no unreasonable adverse health effects. The PAD is the RfD divided by

the Food Quality Protection Act (FQPA) Safety Factor. Dietary risk is expressed as a percentage of the PAD. HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the chronic risk assessment in more detail are available on the EPA/pesticides web site: “Available In formation on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000 /July /Day- 12/6061.pdf; or see SOP 99.6 (8/20/99). The most recent dietary

exposure assessment for quizalofop - ethyl was perfor med to support s ection 3 registration for use on b arley , wheat, s unflower and f lax. [ Christina Swartz, D 31475 , 31 / 7/2006 ]. **II. Residue Information**  **Established and Proposed Tolerances:** Presently , quizalofop ethyl is registered for uses on canola, crambe, cotton, dry beans, dry

and succulent peas, lentils, mint, snap beans, soy bean, sugar beets, b arley , flax, sunflower and wheat. Tolerances are established under 40 CFR §180.441(a)(1) for the combined residues of quizalofop ethyl and quizalofop , all expressed as quizalofop ethyl in/on agricultural commodities except as listed in Section (a)(3), under §180.441(a)(2) for the combined residues of quizalofop ethyl, quizalofop, and quizalofop methyl, all expressed as quizalofop ethyl, for egg, fat, m eat, meat by products, milk and milk fat, and under §180.441(a)(3) for the combined residues of quizalofop - P ethyl ester, quizalofop - P, and the S - enantiomers of the ester and the acid, expressed as quizalofop - P ethyl ester, for sugar beet, barley , wheat sun flower seed, canola, cotton, lentil, vegetable subgroups 6 and 7A, peppermint and spearmint. Other tolerances include a time limited tolerance under §180.441(a)(4) which expired 6/14/1999 and a tolerance with regional registration under §180.441(a)(4)(c) on pineapple. The following proposed tolerances have been included in the dietary exposure anal ys es , in addition to those already established under 40 CFR §180.441.

Rapeseed, subgroup 20A, except flax, seed 1. 5 ppm Sorghum, grain 0.20 ppm Corn, grain 0.02 ppmQuizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

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### The inputs used were (i) tolerance level residues for all commodities, (ii) 100 percent crop treated (%CT) and (iii) DEEMTM ver. 7.78) default processing factors., **III .**  **Drinking Water Residues u**  **sed in the Chronic Risk Assessment:** A drinking water exposure memo was generated for existing and proposed uses of quizalofop [ S . Wente , 07 / 19 /20 11 , D3 84661 ]. A Tier II drinking water assessment of surface water was performed based on Index Reservoir settings , using the linked PRZM - EXAMs models . The sorghum application scenario was used to pr edict an estimated drinking water concentration (EDWC) of 2.006 ppb for chronic exposure. For ground water sources, the SCI GROW model was used to predict an EDWC of 1.29 ppb for chronic exposure . Sin ce the surface water concentration was the highest, the chronic dietary risk assessment was conducted assuming a residue of 0.00 2 ppm for all water sources (direct and indirect). **IV .**  **Program and Consumption Information** Chronic dietary

exposure assessment s were conducted using DEEM - FCIDTM (ver. 2.03), which incorporates consumption data from USDA’s CSFII 1994 - 1996 and 1998. The 1994 - 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non consecutive survey

day s. Food s “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. Based on anal ys is of the 1994 - 96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 ye ar old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and a dults 50+ years old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. **V. Toxicological Information** There are no appropriate endpoints/doses selected for acute dietary risk a ssessment since there were no effects observed in oral toxicity studies that could be attribut ed to a single dose exposure. The chronic reference dose (c RfD ) is established based on a combined chronic toxicity /carcinogenicity s tudy

in rats , in which liver effects and anemia were observed at the LOAEL. The FQPA factor was reduced to 1X, and there are no toxicity data gaps; therefore, the combined uncertainty

factor (UF) of 100X for quizalofop - P - ethyl is based solely on inter - and intra - species differences. A summary of the toxicological doses and endpoints selected for dietary exposure assessment is provided in Table 1. **Table1. Quizalofop -**  **P -**  **ethyl Toxicological Endpoints for Dietary Analysis**Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

page 4 of 8 **Exposure Scenario**  **Dose Used in Risk**

**Assess me**  **nt, UF**  **FQPA SF and Level of** 

**Concern for Risk Assess**  **me nt**  **Study and Toxicological Effects** Acute Dietary [all populations] An acute dietary endpoint was not selected based on the absence of an appropriate endpoint attributed to a single

dose. Chronic Dietary [all populations] NOAEL= 0.9 mg/kg/day

UF=100 Chronic RfD= 0.009 mg/kg/day FQPA SF = 1X cPAD = cRfD FQPA SF = 0.009 mg/kg/day Chronic Toxicity/ Carcinogenicity Study in Rats

LOAEL = 3.7 mg/kg/day based on increased incidence of centrilobular enlargement of the liver in both sexes and mild anemia in males. Cancer Quizalofop - p - ethyl is classified as "not likely" to be a human carcinogen 1 UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, cPAD = chronic population adjusted dose, RfD = reference dose. 

### V**I . Results/Discussion**  The chronic dietary

risk estimates are  29 % cPAD (See Table 2) and are therefore below HED’s level of concern (children 1 - 2 years old were the most highly exposed population). **Table 2**  **: Summary of Chronic Dietary Exposure and Risk for**  **Quizalofop -**  **P -**  **ethyl (drinking water included)**  Population Subgroup cPAD (mg/kg/day) Chronic Exposure (mg/kg/day) %cPAD General U.S. Population

0.0 09 0.00 10 25 11 All Infants (< 1 year old) 0.0024 77 2 8 **Children 1 -**  **2 years old 0.002**  **6 36**  **2 9**  ***** Children 3 - 5 years old 0.002 3 15 2 6 Children 6 - 12 ye ars old 0.0015 90 1 8 Youth 13 - 19 years old 0.000 9 78 1 1 Adults 20 - 49 years old 0.000 803 9 Adults 50+ years old 0.000 685 8 Females 13 - 49 years old 0.000 767 9 

### * Children 1 - 2 years old were the most highly exposed population 

### V**I I. Characterization**  **of Inputs/Outputs** The chronic anal ys is was based on conservative assumptions (tolerance level residues and 100 %CT) for food commodities, A modeled drinking water estimate was used is the assessment. The drinking water assessment of surface water was perf ormed to assess drinking w ater e xposure for quizalofop - p - e thyl in s upport of f ield c orn and sorghum . Since the drinking water estimate was generated using the site/scenario which produced the highest estimated surface water concentration, and since conservative assumptions were used for food, HED concludes that the exposure estimates provided in this document are highl y conservative and is not likely to underestimate risk. **VII I**  **. Conclusions** The chronic dietary

risk estimates are  2 9 % cPAD and are therefore below HED’s level of concern (children 1 - 2 years old were the most highly exposed population).Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

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### VI **X . List of Attachments**  Attachment 1: DEEM - FCID  chronic residue file Attachment 2: DEEM - FCID  chronic exposure estimates **Attachm ent 1:**  **DEEM -**  **FC ID**   **chronic residue file** U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for QUIZALOFOP - ETHYL 1994 - 98 data Residue file: C: \ Documents and Settings \ stadayon \ My Documen ts \ Work in Progress \ quizalofop \ Revised quizo_newuse 11c.R98 Adjust. #2 NOT used Analysis Date 10 - 25 - 2011 Residue file dated: 10 - 25 - 2011/07:15:38/8 Reference dose (RfD) = 0.009 mg/kg bw /day Comment:Standard UFs apply (100X)

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 15000250 15 Barley, pearled barley 0.050000 1.000 1.000 15000251 15 Barley, pearled barley - babyfood 0.050000 1.000 1.000 15000260 15 Barley, flour 0.050000 1.000 1.000 15000261 15 Barley, flour - babyfood 0.050000 1.000 1.000 15000270 15 B arley, bran 0.050000 1.000 1.000 06030300 6C Bean, black, seed 0.400000 1.000 1.000 06020310 6B Bean, broad, succulent 0.250000 1.000 1.000 06030320 6C Bean, broad, seed 0.400000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.250000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.400000 1.000 1.000 06030350 6C Bean, great northern, seed 0.400000 1.000 1.000 06030360 6C Bean, kidney, seed 0.400000 1.000 1.000 06020370 6B Bean, lima, succulent 0.250000 1.000 1.000 06030380 6C Bean, lima, seed 0.400000 1.0 00 1.000 06030390 6C Bean, mung, seed 0.400000 1.000 1.000 06030400 6C Bean, navy, seed 0.400000 1.000 1.000 06030410 6C Bean, pink, seed 0.400000 1.000 1.000 06030420 6C Bean, pinto, seed 0.400000 1.000 1.000 06010430 6A Bean, snap, succulent 0.250000 1.000 1.000 06010431 6A Bean, snap, succulent - babyfood 0.250000 1.000 1.000 21000440 M Beef, meat 0.020000 1.000 1.000 21000441 M Beef, meat - babyfood 0.020000 1.000 1.000 21000450 M Beef, meat, dried 0.020000 1.920 1.000 21000460 M Be ef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts - babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.050000 1.000 1.000 21000471 M Beef,fat - babyfood 0.050000 1.000 1.000 21000480 M Beef, kidney 0.050000 1.000 1.000 21000490 M Beef, liver 0.050000 1.000 1.000 21000491 M Beef, liver - babyfood 0.050000 1.000 1.000 01010520 1A Beet, sugar 0.100000 1.000 1.000 01010521 1A Beet, sugar - babyfood 0.100000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.200000 1.00 0 1.000 01010531 1A Beet, sugar, molasses - babyfood 0.200000 1.000 1.000 40000930 P Chicken, meat 0.020000 1.000 1.000 40000931 P Chicken, meat - babyfood 0.020000 1.000 1.000 40000940 P Chicken, liver 0.050000 1.000 1.000 40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 40000951 P Chicken, meat byproducts - babyfoo 0.050000 1.000 1.000 40000960 P Ch icken, fat 0.050000 1.000 1.000 40000961 P Chicken, fat - babyfood 0.050000 1.000 1.000 40000970 P Chicken, skin 0.050000 1.000 1.000 40000971 P Chicken, skin - baby food 0.050000 1.000 1.000 06030980 6C Chickpea, seed 0.400000 1.000 1.000 06030981 6C Chickpea, seed - babyfood 0.400000 1.000 1.000 06030990 6C Chickpea, flour 0.400000 1.000 1.000 15001200 15 Corn, field, flour 0.020000 1.000 1.000 15001201 15 Corn, field, flour - babyfood 0.020000 1.000 1.000 15001210 15 Corn, field, meal 0.020000 1.00 0 1.000Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

page 6 of 8 15001211 15 Corn, field, meal - babyfood 0.020000 1.000 1.000 15001220 15 Corn, field, bran 0.020000 1.000 1.000 15001230 15 Corn, field, starch 0.020000 1.000 1.000 15001231 15 Corn, field, starch - babyfood 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1.000 1.000 15001241 15 Corn, field, syrup - babyfood 0.020000 1.000 1.000 15001250 15 Co rn, field, oil 0.020000 1.000 1.000 15001251 15 Corn, field, oil - babyfood 0.020000 1.000 1.000 95001280 O Cottonseed, oil 0.100000 0.100 1.000 95001281 O Cottonseed, oil - ba byfood 0.100000 1.000 1.000 70001450 P Egg, whole 0.020000 1.000 1.000 70001451 P Egg, whole - babyfood 0.020000 1.000 1.000 70001460 P Egg, white 0.020000 1.000 1.000 70001461 P Egg, white (solids) - babyfood 0.020000 1.000 1.000 70001470 P Egg, yolk 0.020000 1.000 1.000 70001471 P Egg, yolk - babyfood 0.020000 1.00 0 1.000 20001630 20 Flaxseed, oil 0.050000 1.000 1.000 23001690 M Goat, meat 0.020000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.050000 1.000 1.000 23001720 M Goat, kidney 0.050000 1.000 1.000 23001730 M Goat, liver 0.050000 1.000 1.000 06031820 6C Gu ar, seed 0.400000 1.000 1.000 06031821 6C Guar, seed - babyfood 0.400000 1.000 1.000 24001890 M Horse, meat 0.020000 1.000 1.000 06032030 6C Lentil, seed 0.050000 1.000 1.000 27002220 D Milk, fat 0.250000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.250000 1.000 1.000 27012230 D Milk, nonfat solids 0.010000 1.000 1.000 27012231 D Milk, nonfat solids - baby food/in 0.010000 1.000 1.000 27022240 D Milk, water 0.010000 1.000 1.000 27022241 D Milk, water - babyfood /infant form 0.010000 1.000 1.000 27032251 D Milk, sugar (lactose) - baby food/ 0.010000 1.000 1.000 06022550 6B Pea, succulent 0.300000 1.000 1.000 06022551 6B Pea, succulent - babyfood 0 .300000 1.000 1.000 06032560 6C Pea, dry 0.250000 1.000 1.000 06032561 6C Pea, dry - babyfood 0.250000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.300000 1.000 1.000 06032580 6C Pea, pigeon, seed 0.250000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.300000 1.000 1.000 95002750 O Peppermint 2.000000 1.000 1.000 95 002760 O Peppermint, oil 2.000000 1.000 1.000 95002790 O Pineapple 0.100000 1.000 1.000 95002791 O Pineapple - babyfood 0.100000 1.000 1.000 95002800 O Pine apple, dried 0.100000 5.000 1.000 95002810 O Pineapple, juice 0.100000 1.700 1.000 95002811 O Pineapple, juice - babyfood 0.100000 1.700 1.000 25002900 M Pork, meat 0.020000 1.000 1.000 25002901 M Pork, meat - babyfood 0.020000 1.000 1.000 25002910 M Pork, skin 0.050000 1.000 1.000 25002920 M Pork, meat byproducts 0 .050000 1.000 1.000 25002921 M Pork, meat byproducts - babyfood 0.050000 1.000 1.000 25002930 M Pork, fat 0.050000 1.000 1.000 25002931 M Pork, fat - babyfood 0.050000 1.000 1.000 25002940 M Pork, kidney 0.050000 1.000 1.000 25002950 M Pork, liver 0.050000 1.000 1.000 60003010 P Poultry, other, meat 0.020000 1.000 1.000 60 003020 P Poultry, other, liver 0.050000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 60003040 P Poultry, other, fat 0.050000 1.000 1.000 60003050 P Poultry, other, skin 0.050000 1.000 1.000 20003190 20 Rapeseed, oil 1.500000 1.000 1.000 20003191 20 Rapeseed, oil - babyfood 1.500000 1.000 1.000 26003390 M Sh eep, meat 0.020000 1.000 1.000 26003391 M Sheep, meat - babyfood 0.020000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.050000 1.000 1.000 26003411 M Sheep, fat - babyfood 0.050000 1.000 1.000 26003420 M Sheep, kidney 0.050000 1.000 1.000 26003430 M Sheep, liver 0.050000 1.000 1.000 15003440 15 Sorghum, grain 0.200000 1.000 1.000Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

page 7 of 8 15003450 15 Sorghum, syrup 0.200000 1.000 1.000 06003470 6 Soybean, seed 0.050000 1.00 0 1.000 06003480 6 Soybean, flour 0.500000 1.000 1.000 06003481 6 Soybean, flour - babyfood 0.500000 1.000 1.000 06003490 6 Soybean, soy milk 0.050000 1.000 1.000 06003491 6 Soybean, soy milk - babyfood or in 0.050000 1.000 1.000 06003500 6 Soybean, oil 1.000000 1.000 1.000 06003501 6 Soybean, oil - babyfood 1.000000 1.000 1.000 95003520 O Sp earmint 2.000000 1.000 1.000 95003530 O Spearmint, oil 2.000000 1.000 1.000 20003640 20 Sunflower, seed 1.900000 1.000 1.000 20003650 20 Sunflower, oil 1.900000 1.000 1.000 20003651 20 Sunflower, oil - babyfood 1.900000 1.000 1.000 50003820 P Turkey, meat 0.020000 1.000 1.000 50003821 P Turkey, meat - babyfood 0.020000 1.000 1.000 50003830 P Turkey, liver 0.050000 1.000 1.000 50003831 P Turkey, liver - babyfood 0.050000 1.000 1.000 50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 50003841 P Turkey, meat byproducts - babyfood 0.050000 1.000 1.000 50003850 P Turkey, fat 0.050000 1.000 1.000 50003851 P Tu rkey, fat - babyfood 0.050000 1.000 1.000 50003860 P Turkey, skin 0.050000 1.000 1.000 50003861 P Turkey, skin - babyfood 0.050000 1.000 1.000 86010000 O Water, direct, all sources 0.002000 1.000 1.000 86020000 O Water, indirect, all sources 0.002000 1.000 1.000 15004010 15 Wheat, grain 0.050000 1.000 1.000 15004011 15 Wheat, grain - babyfood 0.050000 1.000 1.000 15004020 15 Wheat, flour 0.050000 1.000 1.000 15004021 15 Wheat, flour - babyfood 0.050000 1.000 1.000 15004030 15 Wheat, germ 0.050000 1.00 0 1.000 15004040 15 Wheat, bran 0.050000 1.000 1.000



### Attachment 2: **DEEM -**  **FCID**  **chronic exposure estimates**Quizalofop - P - ethyl ( 128709 , 128711 ) Dietary Exposure Assessment D 39 5387

page 8 of 8 U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for QUIZALOFOP - ETHYL (1994 - 98 data) Residue file name: C: \ Documents and Settings \ stadayon \ My Documents \ Work in Progress \ quizalofop \ Revised quizo_newuse 11c.R98 Adju stment factor #2 NOT used. Analysis Date 10 - 25 - 2011/07:21:12 Residue file dated: 10 - 25 - 2011/07:15:38/8 Reference dose (RfD, Chronic) = .009 mg/kg bw/day COMMENT 1: Standard UFs apply (100X)

============================================================== ================= Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.001025 11.4% U.S. Population (spring season) 0.001030 11.4% U.S. Population (summer season) 0.001003 11.1% U.S. Populati on (autumn season) 0.001029 11.4% U.S. Population (winter season) 0.001039 11.5% Northeast region 0.000986 11.0% Midwest region 0. 001056 11.7% Southern region 0.001011 11.2% Western region 0.001049 11.7% Hispanics 0.001136 12.6% Non - h ispanic whites 0.000998 11.1% Non - hispanic blacks 0.001079 12.0% Non - hisp/non - white/non - black 0.001053 11.7% All infants (< 1 year) 0.002477 27.5% Nursing infants 0.000873 9.7% Non - nursing infants 0.003086 34.3% Children 1 - 6 yrs 0.002374 26.4 % Children 7 - 12 yrs 0.001511 16.8% Females 13 - 19 (not preg or nursing) 0.000859 9.5% Females 20+ (not preg or nursing) 0.000704 7.8% Females 13 - 50 yrs 0.000834 9.3% Females 13+ (preg/not nursing) 0.000894 9.9% Females 13+ (nursing) 0.001026 11.4% Males 13 - 19 yrs 0.001089 12.1% Males 20+ yrs 0.000815 9.1% Seniors 55+ 0.000676 7.5% Children 1 - 2 yrs 0.002636 29.3% Children 3 - 5 yrs 0.002315 25.7% Children 6 - 12 yrs 0.001590 17.7% Youth 13 - 19 yrs 0.000978 10.9% Adults 20 - 49 yrs 0.000803 8.9% Adults 50+ yrs 0.000685 7.6% Females 13 - 49 yrs 0.000767 8.5%