UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

W ASIDNGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

MEMORANDUM 

Date: 

Subject: 

From/To: 

Through: 

23-April-20 14 

Flutriafol. Acute and Chronic Dietary Exposure and Risk Assessment in Support of 

Tolerances for Residues in/on Field Com, Popcorn, Peanut, Wheat, Strawberries, Cucurbit 

Vegetables, Fruiting Vegetables, and Tree Nuts. 

PC Code: 128940 DP Barcodes: 0417188, 0417189 

Decision Nos.: 475694, 478287 Registration Nos.: 67760-75 and 67760-120 

Petition Nos.: 3F8156 and 3F8174 Regulatory Action: Section 3 Registrations 

Risk Assessment Type: dietary Case No.: 7060 

TXR No.: not applicable CAS No.: 76674-21-0 

MRID No: not applicable 40 CFR: 180.629 

Tom Bloem, Chemist ,-· ~ · 

Risk Assessment Bran~ealth ects Dt ision (RAB 1/HED; 7509P) 

" , 

David Hrdy, Senior Biologist, Chemistry an1 EhW~urepr~J~EB)IHED f1~zi (:fj)~ Thurston Morton, Chemist, RAB4/HED 1f:..P' ~ - · 0 

Dietary Exposure Science Advisory Committee (DESAC) Secondary Review 

George F. Kramer, Ph.D., Senior Chemist 

RABl/HED (7509P) 

Executive Summary 

Based on the indentified residues of concern (ROC) and toxicological considerations, HED 

determined that the following three dietary risk assessments are required when evaluating exposure 

to flutriafol: (1) T (1,2,4-triazole); (2) TA (triazolylalanine), TAA (triazolylacetic acid), and TLA 

(triazole lactic acid); and (3) flutriafol and the remaining ROC. The current document concerns 

dietary exposure to flutriafol and those metabolites found to be toxicologically similar to flutriafol 

(#3 in the previous list). For information concerning the toxicity/exposure toT and TA/TAA/TLA, 

see the human-health risk assessment document D411 360 (T. Bloem et al., 23-Apr-20 14 ). 

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model- Food Consumption Intake Database 

(DEEM-FCID, ver. 3.16) which incorporates the food consumption data from the United States 

Department of Agriculture (USDA) National Health and Nutrition Examination Survey, What We 

Eat in America (NHANES/WWEIA; 2003-2008). These analyses were conducted in support of the 

proposed tolerances for residues inion wheat, strawberries, cucurbit vegetables, fruiting vegetables, 

and tree nuts and the proposed label amendments for field com, popcorn, and peanut (D41 5068, T. 

Bloem, 23-Apr-20 14 ). 

Page I of23 
Flutriafol Dietary Exposure and Risk Assessment 0417188 

The acute and chronic analyses assumed tolerance-level residues or tolerance-level residues 

adjusted to account for the ROC for risk assessment, 100% crop treated, and modeled drinking 

water estimates. Since adequate processing studies have been submitted which indicate that 

tolerances for residues inion apple juice, grape juice, dried prunes, and tomato puree are 

unnecessary and since tolerances for residues in/on raisins and tomato paste tolerances are 

established/recommended, the DEEM (ver. 7.81) default processing factors for these 

commodities were reduced to 1. The DEEM (ver. 7.81) default processing factors were retained 

for the remaining relevant commodities. The resulting acute (:::;31% acute population adjusted 

dose (aPAD); females 13-49 years occupied the highest% ofthe aPAD) and chronic (::;51% 

cPAD; children (1-2 years old) had the highest exposure) dietary risk estimates are not of 

concern to HED. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, no-observable adverse-effect level (NOAEL), lowest-observable 

adverse-effect level (LOAEL), e.g.) divided by the required uncertainty or safety factors. For 

acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 

100% of the PAD. References that discuss the acute and chronic risk assessments in more detail 

are available on the EP Npesticides web site: "Available Information on Assessing Exposure 

from Pesticides, A User's Guide," 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-Aug-1999). 

The most recent dietary risk assessment for flutriafol was conducted by T. Bloem (D407105, 27-

May-2013). 

II. Residue Information 

ROC in Plants, Livestock, and Water: Table 1 is a summary of the ROC in primary crops, 

livestock, rotational crops, and water (for further information see D415068 (T. Bloem, 23-Apr2014). Based on the indentified ROC and toxicological considerations, HED determined that the 

following three dietary risk assessments are required when evaluating exposure to flutriafol: (1) 

T; (2) TNT AA/TLA; and (3) flutriafol and the remaining ROC. The current document concerns 

dietary exposure to flutriafol and those metabolites found to be toxicologically similar to 

flutriafol. For further information concerning these conclusions and for information concerning 

the toxicity/exposure to T and TAfT ANTLA see the human-health risk assessment document 

D411360 (T. Bloem et al., 23-Apr-2014). 

Page 2 of23 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 3 of 23

Table 1: Summary of Metabolites and Degradates of Concern for Risk Assessment and Tolerance Enforcement.

Matrix ROC1

Risk Assessment Tolerance Enforcement

coffee, soybean seed, fruit, sugar 

beet, cucurbit vegetables, fruiting 

vegetables, and tree nuts

flutriafol, T, TA, and TAA

flutriafol (free)

cotton (Section 18 use)2, peanut, 

and cereal grains

flutriafol (free and conjugated), defluorinated flutriafol, T, TA, and TAA; 

combined flutriafol (free and conjugated) and defluorinated flutriafol 

residues may be estimate by multiplying the free flutriafol residues by 

2.2x

5

rotational crops (excluding dried 

roughage feed commodities)

flutriafol (free and conjugated), M28, T, TA (free and conjugated), TAA, 

and TLA; combined flutriafol (free and conjugated) and M28 residue may 

be estimated by multiplying the free flutriafol residue by 1.3x5

rotational crops (dried roughage 

feed commodities)

same as that mentioned above but with multiplication of the free flutriafol

residues by 2.0x to account for the combined residues of flutriafol (free and 

conjugated) and M28

poultry3flutriafol, T, TA, and TAA

ruminant

4

flutriafol, M3, M3e, M4, M7, M10, T, TA, and TAA; combined flutriafol, 

M3, M3e, M4, M7, and M10 residues may be estimated by multiplying the 

free flutriafol residue by the following5: skim milk - 58x, cream - 15x, 

liver, 5.3x, kidney 77x, muscle - 6x, and fat - 2x 

water flutriafol and T --

1

 Separate risk assessments are required for T and TA/TAA/TLA; these compounds have been determined to be toxicologically 

different from flutriafol. 

2

 Decision will be reevaluated if a Section 3 use is requested (additional data may be required). 

3

 HED notes that if the poultry dietary burdens increase, then these conclusions will be revisited and poultry metabolism studies 

conducted as specified in OPPTS 860.1300 with [carbinol14C]flutriafol and [triazole-3,5-

14C]flutriafol may be required. 

4

 HED notes that if the ruminant dietary burden increases, then these conclusions will be revisited and ruminant metabolism studies 

conducted as specified in OPPTS 860.1300 with [carbinol14C]flutriafol and [triazole-3,5-

14C]flutriafol may be required. 

5

 The indicated factors are based on results from the metabolism studies or confined rotational crop study.

Residue Estimates for the Acute and Chronic Analyses: HED reviewed a Section 3 request for 

application of flutriafol to wheat, strawberries, cucurbit vegetables, fruiting vegetables, and tree 

nuts and reviewed label amendments for field corn, popcorn, and peanut. Based on the available 

data, HED determined that the tolerances listed in Table 2 for residues of flutriafol per se are 

appropriate (D415068, T. Bloem, 23-Apr-2014). It is noted that the currently-established field 

corn grain (0.01 ppm), popcorn grain (0.01 ppm), and peanut nutmeat (0.09 ppm) tolerances are 

considered adequate to cover the proposed label revisions. 

Table 2: Summary of HED-Recommended Tolerances.

Commodity HED-Recommended Tolerance (ppm)

Strawberry 1.5

Wheat, forage 30

Wheat, hay 15

Wheat, straw 9.0

Wheat, grain 0.15

Wheat, bran 0.30

Wheat, germ 0.25

Corn, field, forage1 5.0

Corn, field, stover1 15

Corn, pop, stover1 15

Peanut, hay 15

Almond hull 15

Almond 0.60
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 4 of 23

Table 2: Summary of HED-Recommended Tolerances.

Commodity HED-Recommended Tolerance (ppm)

Pecan; African tree nut; Brazil nut; Bur oak; Butternut; Cajou; Cashew; Castanha-domaranhao; Coconut; Coquito nut; Dika nut; Guiana chestnut; Hazelnut; Heartnut; 

Hickory nut; Japanese horse-chestnut; Macadamia nut; Mongongo nut; Monkey-pot; 

Pachira nut; Sapucaia nut; balck walnut; English walnut

0.02

Vegetable, cucurbit, group 9 0.30

Vegetable, fruiting, group 8-10 1.0

Tomato, paste 1.5

Hog, fat 0.01

Hog, muscle 0.01

Cattle, liver 0.80

Cattle, meat byproducts, except liver 0.05

Cattle, muscle 0.05

Cattle, fat 0.05

Goat, liver 0.80

Goat, meat byproducts, except liver 0.05

Goat, muscle 0.05

Goat, fat 0.05

Horse, liver 0.80

Horse, meat byproducts, except liver 0.05

Horse, muscle 0.05

Horse, fat 0.05

Sheep, liver 0.80

Sheep, meat byproducts, except liver 0.05

Sheep, muscle 0.05

Sheep, fat 0.05

Milk 0.01

1

 The currently established field corn forage and stover tolerances and popcorn stover tolerances should be increased to the 

indicated levels. 

Crop Residues: Based on the ROC for risk assessment, the dietary exposure analyses assumed 

tolerance-level residues for all of crops excluding peanut, corn (field, sweet, and pop), wheat, and 

cotton; for these commodities and as indicated in Table 1, the tolerance was multiplied by 2.2x 

(peanut, field corn, popcorn, wheat, and cotton (seed and oil); primary crop tolerances) or 1.3x 

(sweet corn; rotational crop tolerance). Since adequate processing studies have been submitted 

which indicate that tolerances for residues in/on apple juice, grape juice, dried prunes, and tomato 

puree are unnecessary and since tolerances for residues in/on raisins and tomato paste are

established/recommended, the DEEM (ver. 7.81) default processing factors for these commodities 

were reduced to 1 (D340513, T. Bloem, 11-Mar-2009; D388603, T. Bloem, 17-Aug-2011; 

D415068, T. Bloem, 23-Apr-2014). The DEEM (ver. 7.81) default processing factors were 

retained for the following commodities: dried apple (8.0x), dried apricot (6.0x), dried banana 

(3.9x), high fructose corn syrup (1.5x), cherry juice (1.5x), dried peach (7.0x), peanut butter 

(1.89x), dried pears (6.25x), dried plantains (3.9x), prune juice (1.4x), tomato juice (1.5x), and 

dried tomato (14.3x). See Table 2 for a summary of residues, adjustment factors, and processing 

factors used in the dietary analysis for the crop commodities.
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 5 of 23

Poultry Residues: The poultry maximum reasonably-balanced dietary burden (MRDB) for risk 

assessment is 0.240 ppm with the bulk of this occupied by cottonseed meal (0.220 ppm; see Table 

4; dietary burdens to flutriafol and the ROC identified as being toxicologically identical to 

flutriafol). Based on an adequate poultry feeding study and the current MRDB, residues of 

flutriafol per se in poultry commodities are expected to be ≤0.005 ppm (see Table 5). HED 

concludes that inclusion of poultry commodities in the risk assessment is unnecessary for the 

following reasons: (1) the cottonseed meal Section 18 tolerance, which occupies the bulk of the 

poultry dietary burden, is based on soybean seed data form foliar application with the Section 18 

application scenario calling for soil application at planting; therefore, the actual poultry dietary 

burden is likely to be significantly lower than that calculated here and (2) the poultry MRDB 

assumed tolerances-level residues for the cotton commodities with the most recent guidance 

indicating that incorporation of median residues for the relevant cotton commodities is acceptable. 

Ruminant and Hog Residues: The beef cattle, dairy cattle, and hog MRDBs for risk assessment 

are 37.372 ppm, 4.218 ppm, and 0.184 ppm, respectively (see Table 4; dietary burdens to 

flutriafol and the ROC identified as being toxicologically identical to flutriafol). Table 5 presents 

a summary of an adequate ruminant feeding study and the estimated residues in ruminant

commodities at the current MRDB. The residue estimate from the feeding level closet to the 

current MRDB was used in the assessment and is in bold in Table 5; if the MRDB falls between 

two of the feeding levels, then the feeding level with the highest estimate residue was used. For 

whole milk, residues were <LOQ at all the dosing levels and the transfer coefficients from the 

highest dosing level, assuming a LOQ residues, was used. 

It is noted that the feeding study monitored for residues of only flutriafol with the ROC for risk 

assessment estimated using the factors listed in Table 1 (factors derived from the metabolism 

study). The factors range from 2-77x and reflect the fact that parent was not the major residue in 

some of the matrices. However, HED concludes that the employed residue estimates are 

conservative as they are comparable to, or significantly higher than, the TRRs from the 

metabolism study (30 ppm dietary burden) and due to the conservative nature of the dietary 

burden calculations. 

Fish: The USDA Pesticide Data Program (PDP) did not monitor for residues of flutriafol in fish. 

The petitioner has submitted a fish bioaccumulation study which yielded maximum 

bioconcentration factors (BCFs), based on total radioactive residues (TRRs), of 6.8x for whole 

fish, 4.7x for muscle tissue, and 12.2x for viscera (TRRs reached a plateau within the study 

exposure period). The study included a 7-day depuration period which indicated the following: 

(1) TRRs in whole fish decreased to 80% by day 1 and to 2% by day 7; (2) TRRs in muscle 

decreased to 3% by day 1; and (3) TRRs in viscera decreased to 31% by day 1 and to 3% by day 7. 

Based on the maximum concentration in surface water of 0.041 ppm (see Section IV below) and 

the 4.7x BCF for muscle, a residue in fish of 0.193 ppm can be calculated. Assuming this residue 

for all fish/shellfish and conducting a dietary analysis with only fish/shellfish, exposures estimates 

are ≤2.1% the aPAD (acute estimates for consumers only; 95th percentile) and ≤0.2% the cPAD. 

Based on these low risk estimates and the conservative nature of the analysis (maximum water 

concentration; maximum BCF for muscle; BCFs are based on TRRs; the depuration data not 

considered), HED concludes that residues in fish are not a significant source of dietary exposure 

and do not need to be included in the analysis (this includes consumption at the subsistence level).
Flutriafol Dietary Exposure and Risk Assessment D417188

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Table 3: Summary of Tolerances, Adjustment Factors, Assessment Residue Levels, and Processing Factors 

for the Crop and Livestock Commodities. 

Commodity Tolerance

(ppm)

Adjustment Factors

for Residues of Concern

Assessment

Residue Level(ppm)

Processing

Factor

Percent Crop 

Treated

banana 0.30 -- 0.30 3.9 - dried 100

coffee, roasted bean 0.15 -- 0.15 1.0 100

coffee, instant 0.30 -- 0.30 1.0 100

cottonseed, oil 0.50 2.2 1.1 1.0 100

grape 1.5 -- 1.5 1.0 - juice 100

grape, raisin 2.4 -- 2.4 1.0 100

peanut 0.09 2.2 0.198 1.89 - peanut butter 100

plantain 0.30 -- 0.30 3.9 - dried 100

beet, sugar 0.08 -- 0.08 1.0 100

soybean 0.35 -- 0.35 1.0 100

pome fruit 11-09 0.40 -- 0.40

1.0 - apple juice

8.0 - dried apple

6.25 - dried pear

100

stone fruit 12-10 1.5 -- 1.5

6.0 - dried apricot

1.5 - cherry juice

7.0 - dried peach

1.0 - dried prune

1.4 - prune juice

100

corn, field, grain 0.01 2.2 0.022 1.5 - syrup 100

corn, field, oil 0.02 2.2 0.044 1.0 100

corn, pop 0.01 2.2 0.022 1.0 100

corn, sweet 0.01 1.3 0.013 1.0 100

wheat grain 0.15 2.2 0.33 1.0 100

wheat bran 0.30 2.2 0.66 1.0 100

wheat germ 0.25 2.2 0.55 1.0 100

strawberry 1.5 -- 1.5 1.0 100

cucurbit vegetable 9 0.30 -- 0.30 1.0 100

fruiting vegetable 8-10 1.0 -- 1.0

1.0 - tomato puree

1.5 - tomato juice

14.3 - tomato dried

100

tomato paste 1.5 -- 1.5 1.0 100

almond 0.60 -- 0.60 1.0 100

pecan and the tree nuts 

pecan represents1 0.02 -- 0.02 1.0 100

1

 See the following document dated 30-Sep-2010: Crop Grouping – Part IX: Analysis of the USDA IR-4 Petition 

to Amend the Crop Group Regulation 40 CFR § 180.41 (c) (16) and Commodity Definitions [40 CFR 180.1 (g)] 

Related to the Crop Group 14 Tree Nuts. Part I. Analysis.

Table 4: Calculation of Dietary Burdens of Flutriafol Residues to Livestock.

Feedstuff Type1 % Dry Matter2 % Diet2 Residue (ppm)1 Dietary Contribution (ppm)3

Beef Cattle

aspirated grain fractions CC 85 5 0.836 (M) 0.049

field corn grain CC 88 75 0.022 (M) 0.019

wheat hay R 88 15 23.98 (HAFT) 4.088

cotton meal PC 89 5 1.10 (T) 0.062

Total burden -- -- 100 -- 4.218

Dairy Cattle

wet apple pomace CC 40 10 0.115 (M) 0.029

field corn grain CC 88 35 0.022 (M) 0.009

wheat forage R 25 20 41.80 (HAFT) 33.44

field corn forage R 40 25 6.03 (HAFT) 3.77

cotton meal PC 89 10 1.10 (T) 0.124

Total burden -- -- 100 -- 37.372
Flutriafol Dietary Exposure and Risk Assessment D417188

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Table 4: Calculation of Dietary Burdens of Flutriafol Residues to Livestock.

Feedstuff Type1 % Dry Matter2 % Diet2 Residue (ppm)1 Dietary Contribution (ppm)3

Poultry

field corn grain CC 88 75 0.022 (M) 0.017

cotton meal PC 89 20 1.10 (T) 0.220

soybean meal PC 89 5 0.05 (M) 0.003

Total burden -- -- 100 -- 0.240

Hog

field corn grain CC 88 85 0.022 (M) 0.019

cotton meal PC 89 15 1.10 (T) 0.165

Total burden -- -- 100 -- 0.182

1

 R: Roughage; CC: Carbohydrate concentrate; PC: Protein concentrate; M = median; HAFT = highest-average field-trial; T = 

tolerance. The cotton and cereal grain residue estimates were multiplied by 2.2 to account for the ROC for risk assessment (see 

Table 1). Tolerances were assumed for cotton commodities as a Section 18 use is registered and residue depicting the uses are 

not available (tolerance is assumed to be a worst-case estimate). 

2

 OPPTS 860.1000 Table 1 Feedstuffs (June 2008). 

3

 Dietary contribution = tolerance ÷ % dry matter x % diet (for poultry and hog % dry matter is not considered). 

Table 5: Summary of Residue Data from Dairy Cattle Feeding Study with Flutriafol.

Matrix Feeding Level

(ppm)

Maximum Flutriafol 

Residue (ppm)

Flutriafol 

Residue:Feed 

Ratio

Anticipated ROC at 1x MRBD2

Dairy Cattle (49059703.der) cattle hog

Whole milk1

(Days 7, 10, 14, 17, 21, 

24, 26, and 28)

5.0 not analyzed -- -- --

16.0 <0.01 0.0006 0.153 --

50.0 <0.01 0.0002 0.049 --

Cream

(Days 14 and 21)

5.0 not analyzed -- -- --

16.0 <0.01 0.0006 0.040 --

50.0 0.0155 0.0003 0.020 --

Skim milk

(Days 14 and 21)

5.0 not analzyed -- -- --

16.0 <0.01 0.0006 0.153 --

50.0 <0.01 0.0002 0.049 --

Liver

5.0 0.444 0.0888 17.589 0.087

16.0 0.770 0.0481 9.532 0.047

50.0 1.95 0.0390 7.725 0.038

Kidney

5.0 <0.01 0.0020 5.755 0.0283

16.0 0.0156 0.0010 2.806 0.0138

50.0 0.153 0.0031 8.806 0.043

Muscle, round

5.0 <0.01 0.0020 0.448 0.0022

16.0 <0.01 0.0006 0.140 0.0007

50.0 0.0644 0.0013 0.289 0.0014

Muscle, loin

5.0 <0.01 0.0020 0.448 0.0022

16.0 <0.01 0.0006 0.140 0.0007

50.0 0.0660 0.0013 0.296 0.0015

Fat, omental

5.0 <0.01 0.0020 0.149 0.0007

16.0 0.0203 0.0013 0.095 0.0005

50.0 0.336 0.0067 0.502 0.0025

Fat, renal

5.0 <0.01 0.0020 0.149 0.0007

16.0 0.0203 0.0013 0.095 0.0005

50.0 0.317 0.0063 0.474 0.0023

Fat, subcutaneous

5.0 <0.01 0.0020 0.149 0.0007

16.0 0.0214 0.0013 0.100 0.0005

50.0 0.105 0.0021 0.157 0.0008
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 8 of 23

Table 5: Summary of Residue Data from Dairy Cattle Feeding Study with Flutriafol.

Matrix Feeding Level

(ppm)

Maximum Flutriafol 

Residue (ppm)

Flutriafol 

Residue:Feed 

Ratio

Anticipated ROC at 1x MRBD2

Poultry (47510201.de1.doc)3

egg

0.45 <0.01 0.0222 0.005

1.34 not analyzed -- --

4.48 0.0448 0.0100 0.002

muscle

0.45 <0.01 0.0222 0.005

1.34 not analyzed -- --

4.48 <0.01 0.0022 0.0005

fat

0.45 <0.01 0.0222 0.005

1.34 not analyzed -- --

4.48 0.0717 0.0160 0.004

liver

0.45 <0.01 0.0222 0.005

1.34 not analyzed -- --

4.48 0.0978 0.0218 0.005

1

 Data are summarized for days after residues had reached a plateau.

2

 Anticipated ROC at 1x MRDB = (flutriafol residue:feed ratio) x (MRDB) x (adjustment factor to account for ROC for risk 

assessment (see Table 1)). Residues in bold were used in the assessment.

3

Inclusion of residues in poultry commodities in the risk assessment was determined to be unnecessary; for rationale see text above. 

III. Percent Crop Treated Information

The acute and chronic analyses assumed 100% crop treated for all commodities. 

IV. Drinking Water Data

Table 5 is a summary of worst case flutriafol per se surface-/ground-water estimated drinking 

water concentrations (EDWCs) when considering all proposed/registered uses (EFED; D412882, 

J. Wolf, 29-Oct-2013). The bolded EDWCs from Table 5 were incorporated directly into the 

dietary exposure analysis via the water sources direct (all sources) and indirect (all sources) 

commodities. The water models and their description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

Table 5: Maximum Flutriafol EDWCs.

Model Application Rate Concentration (ppb)

Groundwater (PRZM-GW1)

stone fruit (4 x 0.114 lbs ai/acre at 7 day intervals) acute 310

grape (6 x 0.081 lbs ai/acre at 14 day intervals) chronic 202

Surface water (FIRST2) Apples (6 x 0.114 lbs ai/acre at 7 day intervals)3

acute 40.55

chronic 4.03

1

 Pesticide Root Zone Model-Groundwater (PRZM-GW).

2

 FQPA Index Reservoir Screening Tool (FIRST ver. 1.1.1).

3

 The initially proposed application rate for apple. 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 9 of 23

V. DEEM-FCID Program and Consumption Information

Flutriafol acute and chronic dietary exposure assessments were conducted using the Dietary 

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, 

Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA (2003-

2008). The data are based on the reported consumption of more than 20,000 individuals over 

two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPAdefined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour 

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly 

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for 

the entire U.S. population and within population subgroups. However, for acute exposure 

assessment, consumption data are retained as individual consumption events. Based on analysis 

of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years 

old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 10 of 23

VI. Toxicological Information

Table 6 is a summary of the toxicological doses and endpoints for flutriafol dietary exposure 

assessment; based on the toxicological database and residue assumptions, RAB1 concluded that 

the Food Quality Protection Act (FQPA) safety factor (SF) may be reduced to 1x. For a 

complete discussion concerning these conclusions, see D405792 (T. Bloem et al., 27-Mar-2013).

Table 6: Summary of Toxicological Doses and Endpoints for Flutriafol Dietary Exposure Assessment1.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, Level of 

Concern for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary 

(Females, 13-49 

Years of Age)

NOAEL = 

7.5 mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 1x

aRfD = 

0.075 mg/kg/day

aPAD =

0.075 mg/kg/day

Developmental study – rabbit; LOAEL = 15 mg/kg, based 

on decreased number of live fetuses, complete litter 

resorptions and increased post-implantation loss. 

Acute Dietary 

(General 

Population, 

Including Infants 

and Children)

NOAEL = 

250 mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 1x

aRfD = 

2.5 mg/kg/day

aPAD =.

2.5 mg/kg/day

Neurotoxicity screening battery – rat; LOAEL = 750 

mg/kg, based on decreased body weight, body-weight gain, 

absolute and relative food consumption, and clinical signs 

of toxicity in both sexes: dehydration, urine-stained 

abdominal fur, ungroomed coat, ptosis, decreased motor 

activity, prostration, limp muscle tone, muscle flaccidity, 

hypothermia, hunched posture, impaired or lost righting 

reflex, scant feces; in males: red or tan perioral substance, 

chromodacryorrhea, chromorhinorrhea and labored 

breathing, and in females: piloerection and bradypnea.

Chronic Dietary 

(All populations)

NOAEL = 

5 mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 1x

cRfD =

0.05 mg/kg/day

cPAD = 

0.05 mg/kg/day

Chronic toxicity – dog; LOAEL = 20 mg/kg/day, based on

adverse liver findings (increased liver weights, increased 

centrilobular hepatocyte lipid in the liver, and increases in 

alkaline phosphatase, albumin, and triglycerides), 

increased adrenal cortical vacuolation of the zona 

fasciculata, and marked hemosiderin pigmentation in the 

liver and spleen in both sexes; mild anemia (characterized 

by decreased hemoglobin, hematocrit, and red blood cell 

count) in the males; and initial body-weight losses, 

decreased cumulative body-weight gains, and increased 

adrenal weights in the females.

Cancer 

(oral, dermal, 

inhalation)

Classification: “Not likely to be Carcinogenic to Humans” based on the carcinogenicity studies in rats and mice. 

1

 Point of departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark 

the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = noobserved adverse-effect level. LOAEL = lowest-observed adverse-effect level. UF = uncertainty factor. UFA = extrapolation from 

animal to human (intraspecies). UFH = potential variation in sensitivity among members of the human population (interspecies). 

PAD = population-adjusted dose (a = acute, c = chronic). RfD = reference dose (a = acute, c = chronic). 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 11 of 23

VII. Results/Discussion & Conclusions

The unrefined acute (≤31% aPAD; females 13-49 years occupied the highest % of the aPAD) 

and chronic (≤51% cPAD; children (1-2 years old) had the highest exposure) analyses resulted in 

risk estimates less than HED's level of concern. 

Table 7: Summary of the Acute and Chronic Dietary Exposure and Risk.

Population aPAD 

(mg/kg/day)

Exposure 

(mg/kg/day)1 %aPAD1

cPAD 

(mg/kg/day)

Exposure 

(mg/kg/day) %cPAD

General U.S. Population

2.5

0.027487 1.1

0.05

0.008896 18

All Infants (<1 year old) 0.065963 2.6 0.019913 40

Children 1-2 years old 0.060251 2.4 0.025382 51

Children 3-5 years old 0.046566 1.9 0.018434 37

Children 6-12 years old 0.029389 1.2 0.010803 22

Youth 13-19 years old 0.020440 <1 0.006565 13

Adults 20-49 years old 0.022428 <1 0.007519 15

Adults 50-99 years old 0.020955 <1 0.007621 15

Females 13-49 years old 0.075 0.023031 31 0.007469 15

1

 95th percentile (tier 1 analysis)

VIII. Characterization of Inputs/Outputs

The acute and chronic analysis could be refined through the incorporation of maximum or average 

field trial residues, residue monitoring data, percent crop treated estimates, and/or empirical 

processing factors. Refined analyses are not needed at this time since the risk estimates are below 

HED’s LOC. 

IX. Conclusions

The acute and chronic analyses assumed tolerance-level residues or tolerance-level residues 

adjusted to account for the ROC for risk assessment, 100% crop treated, and modeled drinking 

water estimates. Since adequate processing studies have been submitted which indicate that 

tolerances for residues in/on apple juice, grape juice, and dried prunes are unnecessary and since 

tolerances for residues in/on raisins and tomato paste are established/recommended, the DEEM

(ver. 7.81) default processing factors for these commodities were reduced to 1. The DEEM (ver.

7.81) default processing factors were retained for the remaining relevant commodities. The 

resulting acute (≤31% acute population adjusted dose (aPAD); females 13-49 years occupied the 

highest % of the aPAD) and chronic (≤51% cPAD; children (1-2 years old) had the highest 

exposure) exposure estimates are not of concern to HED. 

Attachment 1: DEEM-FCID acute exposure estimates (all populations except females 13-49 years old)

Attachment 2: DEEM-FCID acute exposure estimates (females 13-49 years old)

Attachment 3: DEEM-FCID acute residue file (all populations except females 13-49 years old)

Attachment 4: DEEM-FCID acute residue file (females 13-49 years old)

Attachment 5: DEEM-FCID chronic exposure estimates (all populations)

Attachment 6: DEEM-FCID chronic residue file (all populations)

CC with all attachments: Tamue Gibson (RD; 7505P)

T. Bloem:S10945:PY:(703)605-0217:7509P
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 12 of 23

Attachment 1: DEEM-FCID acute exposure estimates (all populations except females 13-49 years old)

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for FLUTRIAFOL NHANES 2003-2008 2-Day

Residue file: 128940A EXCEPT FEMALES 13-49.R08 Adjustment factor #2 NOT used.

Analysis Date: 04-23-2014/07:13:23 Residue file dated: 04-23-2014/07:07:03

NOEL (Acute) = 250.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "FQPA SF 1x"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.027487 1.10 9095 0.045998 1.84 5435 0.079113 3.16 3160 

Hispanic:

 0.029893 1.20 8363 0.049554 1.98 5045 0.080325 3.21 3112 

Non-Hisp-White:

 0.027110 1.08 9221 0.044211 1.77 5654 0.077721 3.11 3216 

Non-Hisp-Black:

 0.026595 1.06 9400 0.049859 1.99 5014 0.096041 3.84 2603 

Non-Hisp-Other:

 0.029362 1.17 8514 0.048577 1.94 5146 0.071088 2.84 3516 

Nursing Infants:

 0.041099 1.64 6082 0.067661 2.71 3694 0.099497 3.98 2512 

Non-Nursing Infants:

 0.072612 2.90 3442 0.099290 3.97 2517 0.136730 5.47 1828 

Children 1-6:

 0.053396 2.14 4681 0.076355 3.05 3274 0.113765 4.55 2197 

Children 7-12:

 0.027434 1.10 9112 0.038897 1.56 6427 0.055305 2.21 4520 

Male 13-19:

 0.019578 0.78 12769 0.029897 1.20 8362 0.045267 1.81 5522 

Male 20+:

 0.020760 0.83 12042 0.030481 1.22 8201 0.045546 1.82 5488 

Seniors 55+:

 0.020950 0.84 11933 0.029360 1.17 8515 0.044151 1.77 5662 

All Infants:

 0.065963 2.64 3789 0.094991 3.80 2631 0.136404 5.46 1832 

Children 1-2:

 0.060251 2.41 4149 0.091328 3.65 2737 0.141036 5.64 1772 

Children 3-5:

 0.046566 1.86 5368 0.068847 2.75 3631 0.092331 3.69 2707 

Children 6-12:

 0.029389 1.18 8506 0.043300 1.73 5773 0.068488 2.74 3650 

Youth 13-19:

 0.020440 0.82 12230 0.031168 1.25 8020 0.041940 1.68 5960 

Adults 20-49:

 0.022428 0.90 11146 0.032285 1.29 7743 0.046192 1.85 5412 

Adults 50-99:

 0.020955 0.84 11930 0.029910 1.20 8358 0.044715 1.79 5590 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 13 of 23

Attachment 2: DEEM-FCID acute exposure estimates (females 13-49 years old)

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for FLUTRIAFOL NHANES 2003-2008 2-Day

Residue file: 128940A FEMALES 13-49.R08 Adjustment factor #2 NOT used.

Analysis Date: 04-23-2014/07:14:48 Residue file dated: 04-23-2014/07:07:54

NOEL (Acute) = 7.500000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "FQPA SF 1x"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13+ PREG:

 0.021939 29.25 341 0.037510 50.01 199 0.041201 54.93 182 

Female 13-19/NP:

 0.020992 27.99 357 0.032691 43.59 229 0.038142 50.86 196 

Female 20+/NP:

 0.022855 30.47 328 0.032326 43.10 232 0.045035 60.05 166 

Female 13-50:

 0.022938 30.58 326 0.032831 43.78 228 0.044775 59.70 167 

Female 13-49:

 0.023031 30.71 325 0.032892 43.86 228 0.044710 59.61 167 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 14 of 23

Attachment 3: DEEM-FCID acute residue file (except females 13-49 years old)

Filename: C:\Users\tbloem\Documents\work\flutriafol\128940A EXCEPT FEMALES 13-49.R08

Chemical: flutriafol

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day

RfD(Acute): 2.5 mg/kg bw/day NOEL(Acute): 250 mg/kg bw/day

Date created/last modified: 04-23-2014/07:07:03 Program ver. 3.16, 03-08-d

Comment: FQPA SF 1x

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.080000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.080000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.080000 1.000 1.000 

0600347000 6 Soybean, seed 0.350000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.350000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.350000 1.000 1.000 

0600350000 6 Soybean, oil 0.350000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.350000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.350000 1.000 1.000 

0603348000 6C Soybean, flour 0.350000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.350000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.500000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 1.500000 1.000 1.000 

0801377000 8A Tomato, puree 1.000000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 1.000000 1.000 1.000 

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0901075000 9A Cantaloupe 0.300000 1.000 1.000 

0901187000 9A Honeydew melon 0.300000 1.000 1.000 

0901399000 9A Watermelon 0.300000 1.000 1.000 

0901400000 9A Watermelon, juice 0.300000 1.000 1.000 

0902021000 9B Balsam pear 0.300000 1.000 1.000 

0902088000 9B Chayote, fruit 0.300000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.300000 1.000 1.000 

0902135000 9B Cucumber 0.300000 1.000 1.000 

0902308000 9B Pumpkin 0.300000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 

0902356000 9B Squash, summer 0.300000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.300000 1.000 1.000 

0902357000 9B Squash, winter 0.300000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.300000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.400000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.400000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.400000 1.000 1.000 

1100009000 11 Apple, dried 0.400000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.400000 8.000 1.000 

1100010000 11 Apple, juice 0.400000 1.000 1.000 

1100010001 11 Apple, juice-babyfood 0.400000 1.000 1.000 

1100011000 11 Apple, sauce 0.400000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.400000 1.000 1.000 

1100129000 11 Crabapple 0.400000 1.000 1.000 

1100173500 11 Goji berry 1.000000 1.000 1.000 

1100210000 11 Loquat 0.400000 1.000 1.000 

1100266000 11 Pear 0.400000 1.000 1.000 

1100266001 11 Pear-babyfood 0.400000 1.000 1.000 

1100267000 11 Pear, dried 0.400000 6.250 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 15 of 23

1100268000 11 Pear, juice 0.400000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.400000 1.000 1.000 

1100310000 11 Quince 0.400000 1.000 1.000 

1201090000 12A Cherry 1.500000 1.000 1.000 

1201090001 12A Cherry-babyfood 1.500000 1.000 1.000 

1201091000 12A Cherry, juice 1.500000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 1.500000 1.500 1.000 

1202012000 12B Apricot 1.500000 1.000 1.000 

1202012001 12B Apricot-babyfood 1.500000 1.000 1.000 

1202013000 12B Apricot, dried 1.500000 6.000 1.000 

1202014000 12B Apricot, juice 1.500000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 1.500000 1.000 1.000 

1202230000 12B Nectarine 1.500000 1.000 1.000 

1202260000 12B Peach 1.500000 1.000 1.000 

1202260001 12B Peach-babyfood 1.500000 1.000 1.000 

1202261000 12B Peach, dried 1.500000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 1.500000 7.000 1.000 

1202262000 12B Peach, juice 1.500000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 1.500000 1.000 1.000 

1203285000 12C Plum 1.500000 1.000 1.000 

1203285001 12C Plum-babyfood 1.500000 1.000 1.000 

1203286000 12C Plum, prune, fresh 1.500000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 1.500000 1.000 1.000 

1203287000 12C Plum, prune, dried 1.500000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 1.500000 1.000 1.000 

1203288000 12C Plum, prune, juice 1.500000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 1.500000 1.400 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1307359000 13G Strawberry 1.500000 1.000 1.000 

1307360000 13G Strawberry, juice 1.500000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.500000 1.000 1.000 

1400003000 14 Almond 0.600000 1.000 1.000 

1400003001 14 Almond-babyfood 0.600000 1.000 1.000 

1400004000 14 Almond, oil 0.600000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.600000 1.000 1.000 

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400391000 14 Walnut 0.020000 1.000 1.000 

1500120000 15 Corn, field, flour 0.022000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.022000 1.000 1.000 

1500121000 15 Corn, field, meal 0.022000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.022000 1.000 1.000 

1500122000 15 Corn, field, bran 0.022000 1.000 1.000 

1500123000 15 Corn, field, starch 0.022000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.022000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.022000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.022000 1.500 1.000 

1500125000 15 Corn, field, oil 0.044000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.044000 1.000 1.000 

1500126000 15 Corn, pop 0.022000 1.000 1.000 

1500127000 15 Corn, sweet 0.013000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.013000 1.000 1.000 

1500401000 15 Wheat, grain 0.330000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.330000 1.000 1.000 

1500402000 15 Wheat, flour 0.330000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.330000 1.000 1.000 

1500403000 15 Wheat, germ 0.550000 1.000 1.000 

1500404000 15 Wheat, bran 0.660000 1.000 1.000 

2003114001 20C Coconut, oil-babyfood 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 1.100000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 1.100000 1.000 1.000 

3100044000 31 Beef, meat 0.296000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.296000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.296000 1.920 1.000 

3100046000 31 Beef, meat byproducts 9.532000 1.000 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 16 of 23

3100046001 31 Beef, meat byproducts-babyfood 9.532000 1.000 1.000 

3100047000 31 Beef, fat 0.502000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.502000 1.000 1.000 

3100048000 31 Beef, kidney 8.806000 1.000 1.000 

3100049000 31 Beef, liver 9.532000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 9.532000 1.000 1.000 

3200169000 32 Goat, meat 0.296000 1.000 1.000 

3200170000 32 Goat, meat byproducts 9.532000 1.000 1.000 

3200171000 32 Goat, fat 0.502000 1.000 1.000 

3200172000 32 Goat, kidney 8.806000 1.000 1.000 

3200173000 32 Goat, liver 9.532000 1.000 1.000 

3300189000 33 Horse, meat 0.296000 1.000 1.000 

3400290000 34 Pork, meat 0.002200 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.002200 1.000 1.000 

3400291000 34 Pork, skin 0.087000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.087000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.087000 1.000 1.000 

3400293000 34 Pork, fat 0.000700 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.000700 1.000 1.000 

3400294000 34 Pork, kidney 0.028300 1.000 1.000 

3400295000 34 Pork, liver 0.087000 1.000 1.000 

3500339000 35 Sheep, meat 0.296000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.296000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 9.532000 1.000 1.000 

3500341000 35 Sheep, fat 0.502000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.502000 1.000 1.000 

3500342000 35 Sheep, kidney 8.806000 1.000 1.000 

3500343000 35 Sheep, liver 9.532000 1.000 1.000 

3600222000 36 Milk, fat 0.049000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.049000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.049000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.049000 1.000 1.000 

3600224000 36 Milk, water 0.049000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.049000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.049000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.310000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.310000 1.000 1.000 

9500023000 O Banana 0.300000 1.000 1.000 

9500023001 O Banana-babyfood 0.300000 1.000 1.000 

9500024000 O Banana, dried 0.300000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.300000 3.900 1.000 

9500111000 O Coconut, meat 0.020000 1.000 1.000 

9500111001 O Coconut, meat-babyfood 0.020000 1.000 1.000 

9500112000 O Coconut, dried 0.020000 1.000 1.000 

9500113000 O Coconut, milk 0.020000 1.000 1.000 

9500114000 O Coconut, oil 0.020000 1.000 1.000 

9500115000 O Coffee, roasted bean 0.150000 1.000 1.000 

9500116000 O Coffee, instant 0.300000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 2.400000 1.000 1.000 

9500263000 O Peanut 0.198000 1.000 1.000 

9500264000 O Peanut, butter 0.198000 1.890 1.000 

9500265000 O Peanut, oil 0.198000 1.000 1.000 

9500283000 O Plantain 0.300000 1.000 1.000 

9500284000 O Plantain, dried 0.300000 3.900 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 17 of 23

Attachment 4: DEEM-FCID acute residue file (females 13-49 years old)

Filename: C:\Users\tbloem\Documents\work\flutriafol\128940A FEMALES 13-49.R08

Chemical: flutriafol

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day

RfD(Acute): .075 mg/kg bw/day NOEL(Acute): 7.5 mg/kg bw/day

Date created/last modified: 04-23-2014/07:07:54 Program ver. 3.16, 03-08-d

Comment: FQPA SF 1x

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.080000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.080000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.080000 1.000 1.000 

0600347000 6 Soybean, seed 0.350000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.350000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.350000 1.000 1.000 

0600350000 6 Soybean, oil 0.350000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.350000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.350000 1.000 1.000 

0603348000 6C Soybean, flour 0.350000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.350000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.500000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 1.500000 1.000 1.000 

0801377000 8A Tomato, puree 1.000000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 1.000000 1.000 1.000 

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0901075000 9A Cantaloupe 0.300000 1.000 1.000 

0901187000 9A Honeydew melon 0.300000 1.000 1.000 

0901399000 9A Watermelon 0.300000 1.000 1.000 

0901400000 9A Watermelon, juice 0.300000 1.000 1.000 

0902021000 9B Balsam pear 0.300000 1.000 1.000 

0902088000 9B Chayote, fruit 0.300000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.300000 1.000 1.000 

0902135000 9B Cucumber 0.300000 1.000 1.000 

0902308000 9B Pumpkin 0.300000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 

0902356000 9B Squash, summer 0.300000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.300000 1.000 1.000 

0902357000 9B Squash, winter 0.300000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.300000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.400000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.400000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.400000 1.000 1.000 

1100009000 11 Apple, dried 0.400000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.400000 8.000 1.000 

1100010000 11 Apple, juice 0.400000 1.000 1.000 

1100010001 11 Apple, juice-babyfood 0.400000 1.000 1.000 

1100011000 11 Apple, sauce 0.400000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.400000 1.000 1.000 

1100129000 11 Crabapple 0.400000 1.000 1.000 

1100173500 11 Goji berry 1.000000 1.000 1.000 

1100210000 11 Loquat 0.400000 1.000 1.000 

1100266000 11 Pear 0.400000 1.000 1.000 

1100266001 11 Pear-babyfood 0.400000 1.000 1.000 

1100267000 11 Pear, dried 0.400000 6.250 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

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1100268000 11 Pear, juice 0.400000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.400000 1.000 1.000 

1100310000 11 Quince 0.400000 1.000 1.000 

1201090000 12A Cherry 1.500000 1.000 1.000 

1201090001 12A Cherry-babyfood 1.500000 1.000 1.000 

1201091000 12A Cherry, juice 1.500000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 1.500000 1.500 1.000 

1202012000 12B Apricot 1.500000 1.000 1.000 

1202012001 12B Apricot-babyfood 1.500000 1.000 1.000 

1202013000 12B Apricot, dried 1.500000 6.000 1.000 

1202014000 12B Apricot, juice 1.500000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 1.500000 1.000 1.000 

1202230000 12B Nectarine 1.500000 1.000 1.000 

1202260000 12B Peach 1.500000 1.000 1.000 

1202260001 12B Peach-babyfood 1.500000 1.000 1.000 

1202261000 12B Peach, dried 1.500000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 1.500000 7.000 1.000 

1202262000 12B Peach, juice 1.500000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 1.500000 1.000 1.000 

1203285000 12C Plum 1.500000 1.000 1.000 

1203285001 12C Plum-babyfood 1.500000 1.000 1.000 

1203286000 12C Plum, prune, fresh 1.500000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 1.500000 1.000 1.000 

1203287000 12C Plum, prune, dried 1.500000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 1.500000 1.000 1.000 

1203288000 12C Plum, prune, juice 1.500000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 1.500000 1.400 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1307359000 13G Strawberry 1.500000 1.000 1.000 

1307360000 13G Strawberry, juice 1.500000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.500000 1.000 1.000 

1400003000 14 Almond 0.600000 1.000 1.000 

1400003001 14 Almond-babyfood 0.600000 1.000 1.000 

1400004000 14 Almond, oil 0.600000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.600000 1.000 1.000 

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400391000 14 Walnut 0.020000 1.000 1.000 

1500120000 15 Corn, field, flour 0.022000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.022000 1.000 1.000 

1500121000 15 Corn, field, meal 0.022000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.022000 1.000 1.000 

1500122000 15 Corn, field, bran 0.022000 1.000 1.000 

1500123000 15 Corn, field, starch 0.022000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.022000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.022000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.022000 1.500 1.000 

1500125000 15 Corn, field, oil 0.044000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.044000 1.000 1.000 

1500126000 15 Corn, pop 0.022000 1.000 1.000 

1500127000 15 Corn, sweet 0.013000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.013000 1.000 1.000 

1500401000 15 Wheat, grain 0.330000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.330000 1.000 1.000 

1500402000 15 Wheat, flour 0.330000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.330000 1.000 1.000 

1500403000 15 Wheat, germ 0.550000 1.000 1.000 

1500404000 15 Wheat, bran 0.660000 1.000 1.000 

2003114001 20C Coconut, oil-babyfood 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 1.100000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 1.100000 1.000 1.000 

3100044000 31 Beef, meat 0.296000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.296000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.296000 1.920 1.000 

3100046000 31 Beef, meat byproducts 9.532000 1.000 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

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3100046001 31 Beef, meat byproducts-babyfood 9.532000 1.000 1.000 

3100047000 31 Beef, fat 0.502000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.502000 1.000 1.000 

3100048000 31 Beef, kidney 8.806000 1.000 1.000 

3100049000 31 Beef, liver 9.532000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 9.532000 1.000 1.000 

3200169000 32 Goat, meat 0.296000 1.000 1.000 

3200170000 32 Goat, meat byproducts 9.532000 1.000 1.000 

3200171000 32 Goat, fat 0.502000 1.000 1.000 

3200172000 32 Goat, kidney 8.806000 1.000 1.000 

3200173000 32 Goat, liver 9.532000 1.000 1.000 

3300189000 33 Horse, meat 0.296000 1.000 1.000 

3400290000 34 Pork, meat 0.002200 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.002200 1.000 1.000 

3400291000 34 Pork, skin 0.087000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.087000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.087000 1.000 1.000 

3400293000 34 Pork, fat 0.000700 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.000700 1.000 1.000 

3400294000 34 Pork, kidney 0.028300 1.000 1.000 

3400295000 34 Pork, liver 0.087000 1.000 1.000 

3500339000 35 Sheep, meat 0.296000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.296000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 9.532000 1.000 1.000 

3500341000 35 Sheep, fat 0.502000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.502000 1.000 1.000 

3500342000 35 Sheep, kidney 8.806000 1.000 1.000 

3500343000 35 Sheep, liver 9.532000 1.000 1.000 

3600222000 36 Milk, fat 0.049000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.049000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.049000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.049000 1.000 1.000 

3600224000 36 Milk, water 0.049000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.049000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.049000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.310000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.310000 1.000 1.000 

9500023000 O Banana 0.300000 1.000 1.000 

9500023001 O Banana-babyfood 0.300000 1.000 1.000 

9500024000 O Banana, dried 0.300000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.300000 3.900 1.000 

9500111000 O Coconut, meat 0.020000 1.000 1.000 

9500111001 O Coconut, meat-babyfood 0.020000 1.000 1.000 

9500112000 O Coconut, dried 0.020000 1.000 1.000 

9500113000 O Coconut, milk 0.020000 1.000 1.000 

9500114000 O Coconut, oil 0.020000 1.000 1.000 

9500115000 O Coffee, roasted bean 0.150000 1.000 1.000 

9500116000 O Coffee, instant 0.300000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 2.400000 1.000 1.000 

9500263000 O Peanut 0.198000 1.000 1.000 

9500264000 O Peanut, butter 0.198000 1.890 1.000 

9500265000 O Peanut, oil 0.198000 1.000 1.000 

9500283000 O Plantain 0.300000 1.000 1.000 

9500284000 O Plantain, dried 0.300000 3.900 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

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Attachment 5: DEEM-FCID chronic exposure estimates (all populations)

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLUTRIAFOL NHANES 2003-2008 2-day

Residue file name: C:\Users\tbloem\Documents\work\flutriafol\field corn and popcorn 

reduced PHI; new use for tree nut, strawberry, fruiting vegetable, and cucurbit 

vegetable\128940C.R08

 Adjustment factor #2 NOT used.

Analysis Date 04-23-2014/07:15:25 Residue file dated: 04-23-2014/07:08:47

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

COMMENT 1: FQPA SF 1x

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.008896 17.8%

Hispanic 0.009248 18.5%

Non-Hisp-White 0.008976 18.0%

Non-Hisp-Black 0.007781 15.6%

Non-Hisp-Other 0.009560 19.1%

Nursing Infants 0.008881 17.8%

Non-Nursing Infants 0.024840 49.7%

Female 13+ PREG 0.007749 15.5%

Children 1-6 0.020477 41.0%

Children 7-12 0.009913 19.8%

Male 13-19 0.006552 13.1%

Female 13-19/NP 0.006582 13.2%

Male 20+ 0.007306 14.6%

Female 20+/NP 0.007786 15.6%

Seniors 55+ 0.007633 15.3%

All Infants 0.019913 39.8%

Female 13-50 0.007464 14.9%

Children 1-2 0.025382 50.8%

Children 3-5 0.018434 36.9%

Children 6-12 0.010803 21.6%

Youth 13-19 0.006565 13.1%

Adults 20-49 0.007519 15.0%

Adults 50-99 0.007621 15.2%

Female 13-49 0.007469 14.9%

-------------------------------------------------------------------------------
Flutriafol Dietary Exposure and Risk Assessment D417188

Page 21 of 23

Attachment 6: DEEM-FCID chronic residue file (all populations)

Filename: C:\Users\tbloem\Documents\work\flutriafol\field corn and popcorn reduced PHI; new use for 

tree nut, strawberry, fruiting vegetable, and cucurbit vegetable\128940C.R08

Chemical: flutriafol

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day

RfD(Acute): 2.5 mg/kg bw/day NOEL(Acute): 250 mg/kg bw/day

Date created/last modified: 04-23-2014/07:08:47 Program ver. 3.16, 03-08-d

Comment: FQPA SF 1x

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.080000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.080000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.080000 1.000 1.000 

0600347000 6 Soybean, seed 0.350000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.350000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.350000 1.000 1.000 

0600350000 6 Soybean, oil 0.350000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.350000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.350000 1.000 1.000 

0603348000 6C Soybean, flour 0.350000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.350000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.500000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 1.500000 1.000 1.000 

0801377000 8A Tomato, puree 1.000000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 1.000000 1.000 1.000 

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0901075000 9A Cantaloupe 0.300000 1.000 1.000 

0901187000 9A Honeydew melon 0.300000 1.000 1.000 

0901399000 9A Watermelon 0.300000 1.000 1.000 

0901400000 9A Watermelon, juice 0.300000 1.000 1.000 

0902021000 9B Balsam pear 0.300000 1.000 1.000 

0902088000 9B Chayote, fruit 0.300000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.300000 1.000 1.000 

0902135000 9B Cucumber 0.300000 1.000 1.000 

0902308000 9B Pumpkin 0.300000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 

0902356000 9B Squash, summer 0.300000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.300000 1.000 1.000 

0902357000 9B Squash, winter 0.300000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.300000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.400000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.400000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.400000 1.000 1.000 

1100009000 11 Apple, dried 0.400000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.400000 8.000 1.000 

1100010000 11 Apple, juice 0.400000 1.000 1.000 

1100010001 11 Apple, juice-babyfood 0.400000 1.000 1.000 

1100011000 11 Apple, sauce 0.400000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.400000 1.000 1.000 

1100129000 11 Crabapple 0.400000 1.000 1.000 

1100173500 11 Goji berry 1.000000 1.000 1.000 

1100210000 11 Loquat 0.400000 1.000 1.000 

1100266000 11 Pear 0.400000 1.000 1.000 

1100266001 11 Pear-babyfood 0.400000 1.000 1.000 

1100267000 11 Pear, dried 0.400000 6.250 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

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1100268000 11 Pear, juice 0.400000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.400000 1.000 1.000 

1100310000 11 Quince 0.400000 1.000 1.000 

1201090000 12A Cherry 1.500000 1.000 1.000 

1201090001 12A Cherry-babyfood 1.500000 1.000 1.000 

1201091000 12A Cherry, juice 1.500000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 1.500000 1.500 1.000 

1202012000 12B Apricot 1.500000 1.000 1.000 

1202012001 12B Apricot-babyfood 1.500000 1.000 1.000 

1202013000 12B Apricot, dried 1.500000 6.000 1.000 

1202014000 12B Apricot, juice 1.500000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 1.500000 1.000 1.000 

1202230000 12B Nectarine 1.500000 1.000 1.000 

1202260000 12B Peach 1.500000 1.000 1.000 

1202260001 12B Peach-babyfood 1.500000 1.000 1.000 

1202261000 12B Peach, dried 1.500000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 1.500000 7.000 1.000 

1202262000 12B Peach, juice 1.500000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 1.500000 1.000 1.000 

1203285000 12C Plum 1.500000 1.000 1.000 

1203285001 12C Plum-babyfood 1.500000 1.000 1.000 

1203286000 12C Plum, prune, fresh 1.500000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 1.500000 1.000 1.000 

1203287000 12C Plum, prune, dried 1.500000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 1.500000 1.000 1.000 

1203288000 12C Plum, prune, juice 1.500000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 1.500000 1.400 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1307359000 13G Strawberry 1.500000 1.000 1.000 

1307360000 13G Strawberry, juice 1.500000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.500000 1.000 1.000 

1400003000 14 Almond 0.600000 1.000 1.000 

1400003001 14 Almond-babyfood 0.600000 1.000 1.000 

1400004000 14 Almond, oil 0.600000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.600000 1.000 1.000 

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400391000 14 Walnut 0.020000 1.000 1.000 

1500120000 15 Corn, field, flour 0.022000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.022000 1.000 1.000 

1500121000 15 Corn, field, meal 0.022000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.022000 1.000 1.000 

1500122000 15 Corn, field, bran 0.022000 1.000 1.000 

1500123000 15 Corn, field, starch 0.022000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.022000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.022000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.022000 1.500 1.000 

1500125000 15 Corn, field, oil 0.044000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.044000 1.000 1.000 

1500126000 15 Corn, pop 0.022000 1.000 1.000 

1500127000 15 Corn, sweet 0.013000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.013000 1.000 1.000 

1500401000 15 Wheat, grain 0.330000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.330000 1.000 1.000 

1500402000 15 Wheat, flour 0.330000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.330000 1.000 1.000 

1500403000 15 Wheat, germ 0.550000 1.000 1.000 

1500404000 15 Wheat, bran 0.660000 1.000 1.000 

2003114001 20C Coconut, oil-babyfood 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 1.100000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 1.100000 1.000 1.000 

3100044000 31 Beef, meat 0.296000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.296000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.296000 1.920 1.000 

3100046000 31 Beef, meat byproducts 9.532000 1.000 1.000 
Flutriafol Dietary Exposure and Risk Assessment D417188

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3100046001 31 Beef, meat byproducts-babyfood 9.532000 1.000 1.000 

3100047000 31 Beef, fat 0.502000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.502000 1.000 1.000 

3100048000 31 Beef, kidney 8.806000 1.000 1.000 

3100049000 31 Beef, liver 9.532000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 9.532000 1.000 1.000 

3200169000 32 Goat, meat 0.296000 1.000 1.000 

3200170000 32 Goat, meat byproducts 9.532000 1.000 1.000 

3200171000 32 Goat, fat 0.502000 1.000 1.000 

3200172000 32 Goat, kidney 8.806000 1.000 1.000 

3200173000 32 Goat, liver 9.532000 1.000 1.000 

3300189000 33 Horse, meat 0.296000 1.000 1.000 

3400290000 34 Pork, meat 0.002200 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.002200 1.000 1.000 

3400291000 34 Pork, skin 0.087000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.087000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.087000 1.000 1.000 

3400293000 34 Pork, fat 0.000700 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.000700 1.000 1.000 

3400294000 34 Pork, kidney 0.028300 1.000 1.000 

3400295000 34 Pork, liver 0.087000 1.000 1.000 

3500339000 35 Sheep, meat 0.296000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.296000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 9.532000 1.000 1.000 

3500341000 35 Sheep, fat 0.502000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.502000 1.000 1.000 

3500342000 35 Sheep, kidney 8.806000 1.000 1.000 

3500343000 35 Sheep, liver 9.532000 1.000 1.000 

3600222000 36 Milk, fat 0.049000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.049000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.049000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.049000 1.000 1.000 

3600224000 36 Milk, water 0.049000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.049000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.049000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.202000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.202000 1.000 1.000 

9500023000 O Banana 0.300000 1.000 1.000 

9500023001 O Banana-babyfood 0.300000 1.000 1.000 

9500024000 O Banana, dried 0.300000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.300000 3.900 1.000 

9500111000 O Coconut, meat 0.020000 1.000 1.000 

9500111001 O Coconut, meat-babyfood 0.020000 1.000 1.000 

9500112000 O Coconut, dried 0.020000 1.000 1.000 

9500113000 O Coconut, milk 0.020000 1.000 1.000 

9500114000 O Coconut, oil 0.020000 1.000 1.000 

9500115000 O Coffee, roasted bean 0.150000 1.000 1.000 

9500116000 O Coffee, instant 0.300000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 2.400000 1.000 1.000 

9500263000 O Peanut 0.198000 1.000 1.000 

9500264000 O Peanut, butter 0.198000 1.890 1.000 

9500265000 O Peanut, oil 0.198000 1.000 1.000 

9500283000 O Plantain 0.300000 1.000 1.000 

9500284000 O Plantain, dried 0.300000 3.900 1.000