|   | 1. | Recitals/Definitions.  The      above recitals are true and correct and are hereby incorporated into this      Second Amendment as if set forth herein at length.  Any and all      capitalized terms not defined herein shall have the definitions set forth      in the Lease. |
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|   | 2. | Term.  Section 2      of the Lease, as amended by Section 2      of the First Amendment, is hereby further amended by extending the Term      for a period of five (5) years commencing on July 1, 2010 and      expiring on June 30, 2015.  Any and all options to renew      set forth in the Lease are hereby deleted in their    entirety. |
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|   | 3. | Base      Monthly Rent.  Effective as of July 1, 2010 (the      "Effective Date"),      the Base Monthly Rent set forth in Section 4.E.      and Exhibit "C"      of the Lease, as amended by Section 3      of the First Amendment, is hereby further amended and replaced with the      following: |
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| Period                                  |   | Base Monthly Rent |     |   | Annual Base Rent Per Square Foot |   |
|-----------------------------------------|--------|-----------------------------|----------|--------|-----------------------------------------------------------|--------|
| July      1, 2010 — June 30, 2011 |   | $                           | 4,003.31 |   |                                                      | $      | 6.75 |   |
| July      1, 2011 — June 30, 2012 |   | $                           | 4,121.93 |   |                                                      | $      | 6.95 |   |
| July      1, 2012 — June 30, 2013 |   | $                           | 4,246.48 |   |                                                      | $      | 7.16 |   |
| July      1, 2013 — June 30, 2014 |   | $                           | 4,371.02 |   |                                                      | $      | 7.37 |   |
| July      1, 2014 — June 30, 2015 |   | $                           | 4,501.50 |   |                                                      | $      | 7.59 |   |

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|   | 4. | Additional      Rent.  Lessee shall continue to be responsible for any      and all additional rent and other charges due under the Lease, including,      without limitation, Lessee's Proportionate Share of all Operating Expenses      (including Taxes, Lessor's costs of providing insurance and Common Area      maintenance costs); provided, however, from and after the Effective Date,      such payments shall be made without regard to any base year.  In      furtherance of the foregoing, effective as of the Effective      Date: |
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|   | a. | The      first sentence of Section 7.E.      of the Lease is hereby deleted and replaced in its entirety as      follows:  "LESSEE'S cost of the taxes and other items mentioned      in this Article shall be defined as its prorata share of the total annual      taxes regardless of the jurisdiction, jurisdictions, authority or      authorities levying the same." |
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|   | b. | The      first sentence of Section 8.C.      of the Lease is hereby deleted and replaced in its entirety as      follows:  "LESSEE'S cost of the insurance and other items      mentioned in this Article shall be defined as its prorata share of any of      LESSOR'S costs of providing insurance for the Leased Premises, Land,      Building and/or project of which the Leased Premises are a part pursuant      to Section 8.A.      above." |
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|   | c. | The      first sentence of Section 11.I.      of the Lease is hereby deleted and replaced in its entirety as      follows:  "LESSEE shall pay Lessee's Proportionate Share,      pursuant to Articles 4.D. and 4.E., of all costs incurred by LESSOR      associated with the Common Area items mentioned in this      Article 11." |
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|   | 5. | Lessor's      Work.  Lessor shall, at its expense, replace the existing      HVAC system serving the Premises with three (3) new commercial units      providing approximately seventeen (17) tons of  capacity. |
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|   | 6. | AS-IS.  Lessee      hereby acknowledges that it is in possession of the Premises and, except      as otherwise set forth in Section 5      of this Second Amendment, accepts the Premises in its "AS-IS"      condition.  Except as otherwise set forth in Section 5      of this Second Amendment, no agreement of Lessor to alter, remodel,      decorate, clean or improve the Premises or the Building has been made by      Lessor or its agents except as set forth in the  Lease. |
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|   | 7. | Right      of Refusal.  Effective as of the date hereof, the "Right      of Refusal" provision set forth in Exhibit "C"      of the Lease is hereby deleted in itsentirety. |
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|   | 8. | Certification.  Lessee,      by executing this Second Amendment, hereby certifies      that:  (a) the Lease is in full force and effect and has      not been modified except as provided above; (b) there are no      prepayments by or credits due Lessee under the Lease; and (c) Lessee      is not aware of the existence of any default by Lessor, nor of any event      which with the giving of notice or passage of time, or both, would      constitute a breach or default by Lessor under the  Lease. |
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|   | 9. | OFAC.  Lessee      is not (i) acting, directly or indirectly for, or on behalf of, any      person, group, entity or nation named by any Executive Order (including      the September 24, 2001, Executive Order Blocking Property and Prohibiting      Transactions With Persons Who Commit, Threaten to Commit, or Support      Terrorism) or the United States Treasury Department as a terrorist,      "Specially Designated National and Blocked Person," or other banned or      blocked person, entity, or nation pursuant to any Law that is enforced or      administered by the Office of Foreign Assets Control, and is not engaging      in this transaction, directly or indirectly, on behalf of, or instigating      or facilitating this transaction, directly or indirectly, on behalf of,      any such person, group, entity or nation, nor (ii) engaged in any      dealings or transactions, directly or indirectly, in contravention of any      United States, international or other applicable money laundering      regulations or conventions, including, without limitation, the United      States Bank Secrecy Act, the United States Money Laundering Control Act of      1986, the United States International Money Laundering Abatement and      Anti-Terrorist Financing Act of 2001, Trading with the Enemy Act      (50 U.S.C. § 1 et seq., as amended), or any foreign asset      control regulations of the United States Treasury Department (31 CFR,      Subtitle B, Chapter V, as amended) or any enabling legislation      or executive order relating thereto.  Lessee shall, within five      (5) days after Lessor's request, provide such information as Lessor may      require to verify the foregoing representations or as may be required in      order to enable Lessor to comply with any reporting requirements or      applicable laws pertaining to the foregoing    representations. |
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|   | 10. | Broker.  Lessee      and Lessor warrant that they have had no dealings with any broker or agent      in connection with the negotiations or execution of this Second Amendment,      other than Lincoln Property Company (whose commissions shall be paid by      Lessor pursuant to a separate agreement), and Lessor and Lessee agree to      indemnify the other against all costs, expenses, reasonable attorney's      fees, or other liability for commissions or other compensation or charges      resulting from a breach of suchrepresentations. |
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|   | 11. | Miscellaneous.  Except      as expressly set forth herein, the Lease is unmodified and in full force      and effect.  This Second Amendment shall be binding upon and      shall inure to the benefit of the parties and their successors and      assigns. |
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|   | LESSOR:                                                    |
|--------|------------------------------------------------------------|
|   |                                                       |
|   | COLUMBIA TEXAS 2408 TIMBERLOCH      INDUSTRIAL, L.P.,      |
|   | a      Delaware limited partnership                        |
|   |                                                       |
|   | By:           | Columbia      Texas Industrial XVI, LLC, |
|   |                                                       | a      Delaware limited liability company, |
|   |                                                       | its      sole general partner |
|   |                                                       |   |
|   | By:                                                        | Columbia      Industrial Properties, LLC, |
|   |                                                       | a      Delaware limited liability company, |
|   |                                                       | its      sole member |
|   |                                                       |   |
|   | By:                                                        | Lincoln      Industrial Manager, LLC, |
|   |                                                       | a      Delaware limited liability company, |
|   |                                                       | its      managing member |
|   |                                                       |   |
|   | By:                                                        | Lincoln      Advisory Group, Ltd., |
|   |                                                       | a      Texas limited partnership, |
|   |                                                       | its      sole member |
|   |                                                       |   |
|   | By:                                                        | Lincoln      GP Advisory Group, Inc., |
|   |                                                       | a      Texas corporation, |
|   |                                                       | its      general partner |
|   |                                                       |   |
|   |                                                       | By:  | /s/ Gary Kobus |
|   |                                                       |   | Gary      Kobus, its President |
|   |                                                       |
|   | LESSEE:                                                    |
|   |                                                       |
|   | REPROS      THERAPEUTICS INC.,                             |
|   | a      Delaware Corporation                                |
|   |                                                       |
|   | By:                                                   | /s/ Joseph S. Podolski |
|   | Name/Title: Joseph S. Podolski,      President andCEO |

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