UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: 

Subject: 

22-MAR-2016 

Acequinocyl. Chronic Aggregate Dietary (Food + Drinking Water) Exposure and 

Risk Assessment for the Proposed Increase in the Permanent Tolerance for 

Residues inion Hops. 

PC Code: 006329 

Decision No.: 50500 I 

Petition No.: 5F8364 

TXR No.: NA 

OP No.: 0431306 

Registration No.: NA 

Regulatory Action: Amend an Established Tolerance 

CAS No.: 57960-19-7 

MRID No.: NA 

FROM: 

THROUGH : 

40 CFR: § 180.599 

George F. Kramer, Ph.D., Senior Chemist 

Risk Assessment Branch 1 (RAB l )/Health Effects Division (HED; 7509P) 

Ideliz Negr6n-Encarnaci6n, ?J:?rh Chemist~ L- 11 Denn is McNeilly, Chemist ~ '1 ....__ ft. _; v /l 

'-""'" 

~ '-

Dietary Exposure Science Ad sory Council (D SAC) D (7509P) 

and 

Charles W. Smith Ill, Branch Chie 

RAB l/HED (7509P) 

TO: George F. Kramer, Ph.D., Risk Assessor 

RAB 1/HED (7509P) 

and 

Andrew Ertman/Venus Eagle, RM l 

Registration Division (RD; 7505P) 

Executive Summary 

A chronic aggregate dietary (food +drinking water) exposure and risk assessment was conducted 

using the Dietary Exposure Eva luation Model (DEEM-FCID, Version 3. 16) which uses 2003-

2008 food consumption data from the U.S. Department of Agriculture's (USDA's) National 

Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The 

analysis was performed to support a request to increase the existing tolerance for residues of the 

insecticide acequinocyl, 2-(acetyloxy)-3-dodecyl-1,4-naphthalenedione, and its metabolite, 2-

Page I of 12 
Acequinocyl Dietary Exposure and Risk Assessment 0431306 

dodecyl-3-hydroxy-1 ,4-naphthoquinone, expressed as acequinocyl equivalents in/on hops from 

4.0 ppm to 15 ppm. An acute dietary assessment was not conducted for acequinocyl because an 

endpoint of concern attributable to a single dose was not identified; therefore, an acute reference 

dose (aRID) was not established. A cancer dietary assessment was not conducted because 

acequinocyl was classified as not likely to be carcinogenic to humans. 

Chronic Dietary (Food+ Drinking Water) Exposure Results and Characterization 

Tolerance-level residues and 100 percent crop treated (%CT) data were used in the chronic 

dietary assessment. DEEM ver. 7.81 default processing factors were used with the exception of 

those for grape juice and raisins (see "Residue Information" Section of this document for 

details). For the chronic dietary assessment, the general U.S. population and all population 

subgroups have risk estimates that are not of concern to HED. The chronic dietary risk estimate 

for the U.S. population is 14% of the chronic population-adjusted dose (cPAD). The risk of the 

highest exposed population subgroup (children 1-2 years old) occupies 60% of the cPAD. The 

use of anticipated residues (ARs), empirical processing factors, and %CT would refine further 

HED's exposure and risk estimates; however, refinement is not needed at this time. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOA EL, LOAEL, e.g.) divided by the required uncertainty or safety fac tors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: "Available Information on Assessing Exposure 

from Pesticides, A User's Guide," 2 l-JUN-2000, web link: 

http://www.regulations.gov/contentStreamer?document Id=EP A-HQ-0 PP-2007-07 80-

0001 &disposition=attachment&contentType=pdf; or see SOP 99.6 (20-AUG- 1999). 

The most recent dietary risk assessment for acequinocyl was conducted by Sarah Levy (30-

NOV-201 l; D38999). 

II. Residue Information 

Under petition number 5F8364, Arysta LifeScience is requesting to increase the existing 

tolerance for residues of the insecticide acequinocyl and its metabolite, 2-dodecyl-3-hydroxy1,4-naphthoquinone, expressed as acequinocyl equivalents, in/on hops from 4.0 ppm to 15 ppm. 

The purpose of the amended tolerance is to harmonize the value to the established maximum 

residue limit (MRL) in the European Union (EU). 

Permanent tolerances are currently established under 40CFR§180.599(a) for the combined 

residues of acequinocyl and its metabolite, acequinocyl-OH, expressed as acequinocyl 

Page 2of12 
Accquinocyl Dietary Exposure and Risk Assessment D43 1306 

equivalents, in/on a number of plant and livestock commodities. Tolerances for plant 

commodities range from 0.02 ppm (tree nuts and pistachios) to 30 ppm (citrus oil), and 

tolerances for livestock commodities are established at 0.02 ppm in the fat and liver of cattle, 

goat, horse, and sheep. 

Table l. Residues of Concern in Crops, Ruminants, and Orin kine Water. 

Matrix Tolerance Expression Residues for Risk Assessment 

Fruit Crops, Acequinocyl + Acequinocyl-OH (R I) Acequinocyl + Acequinocyl-OH (RI ) Hops 

Ruminants Acequinocyl + Acequinocyl-OH (RI) Acequinocyl + Acequinocyl-OH (RI). In 

liver and kidney, also include AKM-15. 

Rotational Crops Not Determined* Not Determined* 

Drinking Water NA** Acequinocyl + Acequinocyl-OH (RI) 

• A confined rotational crop study has been reviewed and a JO-day plant-back interval has been recommended 

(Memo, S. Levy, 25-JUN-2008; DP# 35 1336). 

**NA = not applicable. 

Residue Data used for the Chronic Assessment: 

Tolerance-level residues and 100 %CT were used in the chronic dietary assessment. DEEM ver. 

7.8 1 default processing fac tors were used with the exception of those for grape juice and raisins. 

As residues were reduced in both grape juice ( <0.02X) and raisin (O. I 5X), separate tolerances 

are not required for these commodities. The DEEM ver. 7.81 default processing factors for juice 

and raisin were set to I as concentration was shown not to occur (Memo, S. Levy, 05-SEP-2007; 

D342805). 

Fish: The USDA Pesticide Data Program (PDP) monitored pestic ide residues in catfish in 2008, 

2009, and 20 I 0. In general, pesticide residues would not be expected to be found in fish unless 

the pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are 

present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide's 

uses and physicochemical properties. However, PDP did not analyze catfish samples for 

acequinocyl. As a result, residues in fish were not included in the assessment. 

Ill. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) (M. Lowit, 07-SEP-201 1; D389520) and 

incorporated directly into this dietary assessment. As there are no proposed or requested changes 

in the acequinocyl label associated with this action, a new drinking water assessment has not 

been performed. Water residues were incorporated directly into DEEM-FCID under the food 

categories "water, direct, all sources" and "water, indirect, all sources." 

Acequinocyl can reach surface water via spray drift and less likely via runoff. Due to its high Kd 

values it is expected to exhibit low mobility in soil and low potential to leach into groundwater. 

Once acequinocyl has entered surface water, it is not li kely to persist as it will hydrolyze to form 

hydroxy-acequinocyl (also known as R-1 ). 

There are no drinking water monitoring data available for acequinocyl or its metabolite 

acequinocyl-OH (Rl), the residues of concern. Groundwater estimated drinking water 

concentrations (EDWCs) were generated for acequinocyl using the Screening Concentration in 

Page 3of12 
Acequinocyl Dietary Exposure and Risk Assessment 0431306 

Ground Water (SCI-GROW) Model. Surface water EDWCs were generated using the Pesticide 

Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) model for all proposed 

uses except cranberry (cranberries are part of the low growing berries subgroup, l 3-07G). 

Cranberry harvesting may involve field flooding and PRZM/EXAMS is not currently 

parameterized to assess this type of scenario; therefore, cranberry was assessed using the 

provisional cranberry model (note that since the provisional cranberry model only uses a one 

year simulation, the highest 30-year annual average concentration is not available for the 

cranberry scenario). 

Similar to previous drinking water assessments provided by EFED, two approaches were used in 

performing the drinking water assessment for proposed acequinocyl uses. In Approach #1, 

acequinocyl was conservatively assumed to be stable to all routes of degradation to account for 

the uncertainties associated with the environmental fate data. In Approach #2, total (acequinocyl 

+ acequinocyl-OH) residues were modeled with the assumption that the half-lives of acequinocyl 

and R 1 are valid and the total toxic residues were modeled to address toxicity concerns with R 1. 

The EDWCs are summarized below in Table 3. Surface water EDWCs for the proposed uses are 

higher than those previously reported for both approaches. The ground water EDWC for the 

current assessment is the same as the last assessment. 

Table 3. Recommended EOWCs of Acequ inocyl Derived from the Previous Uses. 

EDWCs from Surface Water Sources (ug/L)u 

llpproach I llpproach 2 Drinking water Proposed 

source (model) Usc/Sccnario3 (assume no accquinocyl degradation) (combined acequinocyl and RI ) 

l-in-1 0- I-in-I 0-year 

year acute chronic 

Surface water Cherry/M I cherry 6.69 6.69 

(PRZM/EXAMS) (25.89)4 ( 17.84)4 

Small fruit (vine 

Surface water climbing. except fuzzy 6.69 6.69 

(PRZM/EXAMS) kiwifrnit, I 3-07F)/NY (23. I 2)J (15.34)4 

grape 

Surface water Cranberry/Provisional (Provisional 4.24 3.75 

Cranberry Model) Cranberry Model 

Groundwater All proposed uses 3.6 x 10·3 53.6 x 10·3 

(SCIGRO\V) 1 Bolded values are the recommended EDWCs by EFED. 

2 A default PCA of0.87 was applied. 3 Maximum of2 applications of0.3 lb ai/A for all proposed uses. 

30-year l-in-10- I-in-I 0-year 

mean year acute chronic 

6.69 5.59 0.42 (I 0.19)4 

6.69 4.22 0.38 (9.57)4 

-- 3.81 5 1.365 

::;3.6 x I o·

3 3.6 x 10·3 53.6 x 10·

3 

4 EDWC (shown in parentheses) exceeds the solubility limit of acequinocyl (6.69 μg/L at 20°C); therefore, the 

recommended EDWC is 6.69 ppb. 5 Based on a one-year simulation; 1-10-year calculation is not applicable. 

30-ycar 

mean 

0.26 

0.27 

--

53.6 x 10·.1 

Since the surface water EDWCs are higher than the groundwater EDWC, HED selected the 

surface water value for use in the chronic dietary assessment. The EDWC derived via Approach 

# 1 represents the upper-bound value (6.69 ppb) while that derived via Approach #2 represents 

the lower-bound value (1.36 ppb). The 6.69 ppb value was used in this dietary assessment as this 

value assures a conservative assessment. 

IV. DEEM-FCID Program and Consumption Information 

An acequinocyl chronic dietary exposure assessment was conducted using DEEM-FCID, 

Version 3.1 6, which incorporates 2003-2008 consumption data from USDA's 

Page 4of12 
Accquinocyl Dietary Exposure and Risk Assessment D431306 

NHANES/WWElA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (i.e., apple pie) are 

linked to EPA-defined food commodities (i.e., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

2003-2008 NHANES/WWEIA consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<I year old), children l-2 years 

old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, adults 20-49 years 

old, females 13-49 years old, and adults 50-99 years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

V. Toxicological Information 

On 14-0CT-2003, the HED Hazard Identification Assessment Review Committee (HIARC) 

reviewed the recommendations of the toxicology reviewer for acequinocyl with regard to the 

acute and chronic Rills and the toxicological endpoint selection for use as appropri ate in 

occupational/residential exposure risk assessments. The potential for increased susceptibility of 

infants and children from exposure to acequinocyl was also evaluated as required by the Food 

Quality Protection Act (FQPA) of 1996 under the 2002 OPP 1 OX Guidance. Table 4 is a 

summary of the toxicology doses and endpoints selected that are re levant to dietary exposure 

assessment (13-NOV-2003; TXR# 0052234). The acequinocyl risk assessment team confirmed 

that the endpoints selected previously remain appropriate. 

Table 4. Summary of Toxicological Doses and Endpoints for Acequinocyl for Use in Dietary Exposure Risk 

Assessment. 1 

Exposure/ Point of Uncertainty/ RfD, PAD, Level of Study and Toxicological Effects Scenario Departure FQPA SFs Concern 

Acute Dietary An endpoint of concern (effect) 

(General attributable to a single dose was 

Population, not identified in the database. 

including Quanti ti cation of acute risk to 

Infants and general population including 

Children) infants and children is not 

required. 

Chronic NOAEL = UFA = IOX cPAD = cRfD = 18-month carcinogenicity study in 

Dietary 2.7 UF11 = IOX 0.027 mg/kg/day mice; 

(All mg/kg/day FQPA SF = IX LOA EL = 7.0 mg/kg/day based on 

Populations) clinical chemistry and microscopic 

non-neoplastic lesions (brown 

pigmented cells and perivascular 

inflammatory cells in liver). 

Page 5 or 12 
Acequinocyl Dietary Exposure and Risk Assessment D43 1306 

Cancer (oral. dermal. inhalation) Classification: ··Not likely to be Carcinogenic to I lumans." 

1 UF = uncertainty factor. UFA = extrapolation from animal to human (interspecies), UF11 = potential variation in 

sensitivity among members of the human population (intraspecies), FQPA SF = FQPA Safety Factor, NOAEL = noobserved adverse-efTect level. LOAEL =lowest-observed adverse-effect level. RID = reference dose (a = acute. c = 

chronic), PAD = population-adjusted dose. NIA = not applicable. 

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 5 are for the general 

U.S. population, all infants (<I-year old), children 1-2, children 3-5, children 6-1 2, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. An acute dietary assessment was not 

conducted for acequinocyl because an endpoint of concern attributable to a single dose was not 

identified; therefore, an aRfD was not established. A cancer dietary assessment was not 

conducted because acequinocyl was classified as not likely to be carcinogenic to humans. 

The chronic dietary exposure assessment (using tolerance level residues and 100% CT 

information for all registered and proposed uses) was conducted for the general U.S. population 

and various population subgroups. Drinking water was incorporated directl y into the dietary 

assessment using the chronic concentration for ground water generated by the PRZM/EXAMS 

model. This assessment concludes that the chronic dietary risk estimates are not of concern to 

HED for the general U.S. population (14% cPAD) and all population subgroups. The most 

highly exposed population subgroup is children 1-2 years old at 60% of the cPAD. 

Table 5. Summary of Dietary (Food + Drinking Water) Exposure a nd Risk fo r Aceq uinocyl. 

Chronic Dietary1 

Population Subgroup Dietary Exposure %cPAD (mg/kg/day) 

U.S. Population (total) 0.003711 14 

All Infants (<l year old) 0.006769 25 

Children 1-2 vears old 0.016168 60 

Children 3-5 years old 0.011083 41 

Children 6- 12 years old 0.005226 19 

Youth 13- 19 years old 0.002605 10 

Adults 20-49 years old 0.002758 10 

Adults 50+ years old 0.002615 10 

Females 13-49 years old 0.002624 10 1 Chronic dietary endpoint of 0.027 mg/kg/day applies to the general U.S. population and all population subgroups. The values 

for the highest exposed population are bolded. 

VII. Characterization of Inputs/Outputs 

The chronic analysis assumed tolerance-level residues and 100 %CT data. DEEM ver. 7.81 

default processing factors were used with the exception of those for grape juice and raisins. This 

analysis is considered very conservative and could be refined through the use of ARs for all 

commodities, %CT data for registered commodities, and/or additional empirical processing 

factors. 

Page 6of 12 
Acequinocyl Dietary Exposure and Risk Assessment 0431306 

VIII. Conclusions 

A chronic dietary exposure and risk assessment was conducted for the proposed permanent 

tolerance for residues of acequinocyl, including potential exposure from drinking water. 

The chronic dietary (food+ drinking water) exposure to acequinocyl is below HED's level of 

concern for the general U.S. population and all population subgroups. The chronic dietary risk 

utilized 14% cPAD for the general U.S. population and 60% of the cPAD for children 1-2 years 

old, the most highly exposed population subgroup. An acute dietary assessment was not 

conducted fo r acequinocyl because an endpoint of concern attri butable to a single dose was not 

identified; therefore, an aRID was not established. A cancer dietary assessment was not 

conducted because acequinocyl was classified as not likely to be carcinogenic to humans. 

IX. List of Attachments 

Attachment I: Chronic Food + Drinking Water Residue Input File. 

Attachment 2: Chronic Results File. 

Attachment 3: Chronic Results (Food only) File 

ROI: DESAC (27-JAN-2016) 

G.F. Kramer:S I 0957:PY-S:(703)305-5079:7509P:RAB I 

Page 7 of 12 
Acequinocyl Dietary Exposure and Risk Assessment 043 1306 

Attachment 1: Chronic Food + Drinking Water Residue Input File. 

Filename : C: \Users\gkramer\OneDrive - Environmental Protection Agency 

(EPA) \Gk\$$Acequinocyl \006329C.ROS 

Chemical : Acequinocyl 

RfD(Chronic): .027 mg/kg bw/day NOEL(Chronic) : 2.7 mg/kg bw/day 

RfD(Acute): O mg/kg bw/day NOEL(Acute) : O mg/kg bw/day 

Date created/last modified : 06-lS-2015/13:32 : 43 Program ver. 3.16, 03 - 0S-d 

Comment : No acute dietary endpoint ; no t carcinogen. cRfD=cPAD 

EPA Crop 

Code Grp Commodity Name 

Def Res 

(ppm) 

9500177000 0 

9500 178000 0 

95001SSOOO 0 

0602031000 6B 

0602033 000 6B 

0602037000 6B 

0601043000 6A 

0601043001 6A 

0601349500 GAB 

OS0214SOOO SBC 

OS02234 000 SBC 

OS02270000 SB 

OS02271000 SB 

0802271001 SB 

OS02270001 SB 

OS022 72000 SBC 

OS02273000 SBC 

OS02272001 SBC 

OS01374000 SA 

OS01375000 SA 

OS01378000 SA 

080137S001 SA 

OS01379000 SA 

OS01376000 SA 

OS01376001 SA 

OS01377000 SA 

OS01377001 SA 

OS01375001 SA 

0901075000 9A 

0902135000 9B 

09011S7000 9A 

0901399000 9A 

0901400000 9A 

1001106000 lOA 

1001107000 lOA 

lOOllOSOOO lOA 

1003180000 lOC 

10031Sl000 lOC 

1002197000 lOB 

1002199000 lOB 

1002200000 lOB 

1002200001 lOB 

1002201000 lOB 

1002206000 lOB 

1002207000 lOB 

1002 207001 lOB 

1001240000 lOA 

1001241000 lOA 

1001241001 lOA 

100124 2000 lOA 

1003307000 lOC 

1001369000 lOA 

1001370000 lOA 

110000 9000 11 

1100009001 11 

1100007000 11 

1100010000 11 

Grape, leaves 

Grape, raisin 

Hop 

Bean, broad, succulent 

Bean, cowpea, succulent 

Bean, lima , succulent 

Bean, snap, succul ent 

Bean, snap, succulent-babyfood 

Soybean, vegetable 

Eggplant 

Okra 

Pepper , bell 

Pepper, bell, dried 

Pepper, bell, dried-babyfood 

Pepper, bell-babyfood 

Pepper, nonbell 

Pepper, nonbell, dried 

Pepper, nonbell - babyfood 

Tomatillo 

Tomato 

Tomato, dried 

Tomato , dried- babyfood 

Tomato, juice 

Tomato , paste 

Tomato, paste- babyfood 

Tomato, puree 

Tomato, puree-babyfood 

Tomato-babyfood 

Cantaloupe 

cucumber 

Honeydew melon 

Watermelon 

Watermelon , juice 

Citron 

Citrus hybrids 

Citrus, oil 

Grapef ruit 

Grapefruit , juice 

Kumquat 

Lemon 

Lemon, juice 

Lemon, juice-babyfood 

Lemon, peel 

Lime 

Lime, juice 

Lime, juice- babyfood 

Orange 

Orange , juice 

Orange, j uice-babyfood 

Orange, peel 

Pummelo 

Tangerine 

Tangerine, Juice 

Apple, dried 

Apple, dried- babyfood 

Apple, fruit with peel 

Apple, juice 

1.600000 

1.600000 

15.000000 

0 . 250000 

0.250000 

0 . 250000 

0 . 250000 

0.250000 

0.250000 

0 . 700000 

0.700000 

0.700000 

0 . 700000 

0 . 700000 

0 . 700000 

0.700000 

0 . 700000 

0.700000 

0 . 700000 

0.700000 

0 . 700000 

0 . 700000 

0.700000 

0 . 700000 

0 . 700000 

0 . 700000 

0.700000 

0.700000 

0 . 150000 

0 . 150000 

0.150000 

0.150000 

0.150000 

0 . 200000 

0.200000 

30. 000000 

0 . 200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0 . 200000 

0.200000 

0.200000 

0 . 200000 

0.200000 

0.200000 

0 . 200000 

0 . 200000 

0 . 200000 

0.200000 

0.400000 

0.400000 

0 . 400000 

0 . 400000 

Page 8of12 

Adj.Factors 

#1 #2 

1 . 000 

l. 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

l. 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

14.300 

14 . 300 

1 . 500 

5 . 400 

5 . 400 

3.300 

3 . 300 

l. 000 

l. 000 

1 . 000 

l. 000 

1 . 000 

1. 000 

1. 000 

1 . 000 

l. 000 

1. 000 

2 . 100 

1. 000 

1 . 000 

2 . 000 

2 . 000 

1 . 000 

l. 000 

2 . 000 

2 . 000 

1. 000 

l. soo 

l.SOO 

1 . 000 

l. 000 

l. 000 

2 . 300 

8 . 000 

S . 000 

1 . 000 

1 . 300 

l. 000 

1.000 

1.000 

1.000 

1 . 000 

1. 000 

1. 000 

1. 000 

1.000 

1.000 

l. 000 

l. 000 

1.000 

1.000 

1. 000 

l. 000 

1 . 000 

1.000 

1. 000 

1 . 000 

1.000 

l. 000 

1 . 000 

1.000 

1. 000 

1.000 

1.000 

1. 000 

1. 000 

1.000 

1. 000 

1. 000 

l. 000 

1.000 

1. 000 

1. 000 

1.000 

1. 000 

1. 000 

1. 000 

1 . 000 

1. 000 

1 . 000 

1 . 000 

1. 000 

1.000 

1.000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

1 . 000 

1. 000 

l. 000 

Comment 

9E759S 

1E7864 

1E7864 

1E7S64 

9E7598 

9E759S 

1E7S64 

9E759S 

9E759S 

9E7598 

9E759S 

9E759S 

9E759S 

9E759S 

9E759S 

9E759S 

9E7598 

9E7598 

9E759S 

9E759S 

9E759S 

9E7598 

9E759S 

9E7598 

9E7598 

9E7598 

1E7S64 

1E7S64 

1E7S64 

1E7S64 

1E7S64 
Acequinocyl 

1100010001 11 

1100008000 11 

1100008001 ll 

1100011000 ll 

1100011001 ll 

1100129000 11 

1100210000 11 

1100266000 11 

1100267000 11 

1100268000 11 

1100268001 11 

110026600 1 ll 

1100310000 ll 

1201090000 12A 

1201091000 12A 

1201091001 l2A 

1201090001 12A 

1301055000 13A 

1301056000 13A 

1301056001 13A 

1302057000 13B 

1302057001 13B 

1301058000 l3A 

1307130000 13G 

1307131000 13G 

1307132000 13G 

1307132001 13G 

1307130001 l3G 

1304175000 130 

1304176000 130 

1304176001 130 

1304179000 130 

1304195000 130 

1301208000 13A 

1301320000 13A 

1301321000 13A 

1301321001 13A 

1301320001 13A 

1307359000 13G 

1307360000 13G 

1307360001 13G 

1307359001 13G 

1400003000 14 

1400004000 14 

1400004001 14 

1400003001 14 

1400059000 14 

1400068000 14 

1400081000 14 

1400092000 14 

1400155000 l4 

1400156000 14 

1400185000 l4 

1400213000 14 

1400269000 14 

1400282000 14 

1400391000 14 

3100047000 31 

3100047001 31 

3100048000 31 

3100049000 31 

3100049001 31 

3100046000 31 

3100046001 31 

3200171000 32 

3200172000 32 

3200173000 32 

3500341000 35 

3500341001 35 

3500342000 35 

3500343000 35 

Dietary Exposure and Risk Assessment 

Apple, juice-babyfood 

Apple, peeled fruit 

Apple, peeled fruit-babyfood 

Apple, sauce 

Apple. sauce-babyfood 

Crabapple 

Loquat 

Pear 

Pear, dried 

Pear, juice 

Pear, juice-babyfood 

Pear-babyf ood 

Quince 

Cherry 

Cherry, juice 

Cherry, j uice-babyfood 

Cherry-baby food 

Blackberry 

Blackberry, juice 

Blackberry, juice- babyfood 

Blueberry 

Blueberry-baby food 

Boysenberry 

Cranberry 

Cranberry, dried 

Cranberry, juice 

Cranberry, juice-babyfood 

Cranberry-baby food 

Grape 

Grape, juice 

Grape, juice-babyfood 

Grape , wine and sherry 

Kiwifruit, fuzzy 

Loganberry 

Raspberry 

Raspberry, juice 

Raspberry , juice-babyfood 

Raspberry-baby food 

Strawberry 

Strawberry, juice 

Strawberry, juice-babyfood 

Strawberry-babyfood 

Almond 

Almond, oil 

Almond , oil-babyfood 

Almond-baby food 

Brazil nut 

Butternut 

Cashew 

Chestnut 

Hazelnut 

Hazelnut, oil 

Hickory nut 

Macadamia nut 

Pecan 

Pistachio 

Walnut 

Beef, fat 

Beef, fat-babyfood 

Beef, kidney 

Beef, liver 

Beef, liver-babyfood 

Beef, meat byproducts 

Beef, meat byproducts-babyfood 

Goat, fat 

Goat , kidney 

Goat, liver 

Sheep, fat 

0 .400000 

0.400000 

0.400000 

0.400000 

0.400000 

0 .4 00000 

0.400000 

0.400000 

0.400000 

0.400000 

0.400000 

0.400000 

0 . 400000 

l. 000000 

l.000000 

l.000000 

1.000000 

4.000000 

4.000000 

4.000000 

0 . 500000 

0.500000 

4.000000 

0.500000 

0.500000 

0.500000 

0 . 500000 

0.500000 

l. 600000 

l.600000 

l. 600000 

1.600000 

1.600000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

0.500000 

0.500000 

0.500000 

0 . 500000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0 . 020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

0.020000 

Sheep, fat-babyfood 

Sheep, kidney 

Sheep , liver 0.020000 

Page 9of 12 

l.300 1.000 

l.000 1.000 

1.000 1.000 

1. 000 1. 000 

1 . 000 1 . 000 

l.000 l.000 

l. 000 l. 000 

1.000 1.000 

6.250 

1. 000 

l.000 

l. 000 

1.000 

1 . 000 

1 . 500 

1 .500 

1 . 000 

l.000 

1 . 000 

1.000 

1 . 000 

l.000 

l . 000 

1.000 

1.000 

1.100 

l.100 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1. 000 

l . 000 

l . 000 

1.000 

1.000 

l.000 

1.000 

l.000 

1.000 

1. 000 

1.000 

1 .000 

l. 000 

l. 000 

1.000 

l. 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1. 000 

1. 000 

1.000 

1.000 

1 .000 

1.000 

l.000 

l. 000 

1 .000 

1.000 

1. 000 

l. 000 

1 .000 

l. 000 

1.000 

1.000 

l. 000 

l. 000 

1 . 000 

1.000 

1.000 

l. 000 

l.000 

1.000 

l.000 

1.000 

l. 000 

1.000 

1.000 

l.000 

l .000 

1.000 

1.000 

1. 000 

l . 000 

l. 000 

l.000 

l. 000 

1 . 000 

1 . 000 

1 . 000 

1.000 l.000 

l.000 l.000 

l. 000 l. 000 

l. 000 l. 000 

1.000 l.000 

1.000 l.000 

l.000 l.000 

l. 000 l. 000 

l. 000 l. 000 

l. 000 l. 000 

1.000 1.000 

l.000 l.000 

l. 000 l. 000 

1 . 000 l.000 

l.000 l.000 

1. 000 l. 000 

1.000 1 . 000 

l. 000 l. 000 

l.000 1.000 

1.000 1.000 

043 1306 

1E7864 

1E7864 

1E7864 

1E7864 

1E7864 

lE7864 

1E7864 

1E7864 

1E7864 

lE7864 

1E7864 

1E7864 

lE7864 

1E7864 

1E7864 

1E7864 

1E7864 

1E7864 

1E7864 

lE7864 

lE7864 

1E7864 

1E7864 
Acequinocyl Dietary Exposure and Risk Assessment 043 1306 

350034 0000 35 Sheep, meat byproduccs 

8601000000 86A water, direcc, all sources 

8602000000 86B wacer, indirect, all sources 

0 . 020000 

0 . 006690 

0.006690 

Page 10of 12 

1. 000 1.000 

1 . 000 1.000 1E7864 

1 . 000 1 . 000 1E7864 
Acequinocyl Dietary Exposure and Risk Assessment 

Attachment 2: Chronic Results File. 

US EPA 

DEEM- FCID Chronic analys is for ACEQUINOCYL 

2008 2-day 

0431306 

Ver . 3 . 16, 03-08-d 

NHANES 2003-

Residue file name: C: \Users\gkramer\OneDrive -

Agency (EPA)\Gk\$$Acequinocyl\006329C . R08 

Envi ronmental Protec tion 

Adjustment factor #2 used. 

Analysis Date 01 -21 -2016/12 : 41 : 41 

2016/12 : 41 : 08 

Residue file dated: 01-21-

Reference dose (RfD, Chronic) = . 027 mg/kg bw/day 

COMMENT 1 : No acute dietary endpoint; not carcinogen. cRfD=cPAD 

================= ================================= ====== =========== ======= 

Total exposure by population subgroup 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Inf ants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Child ren 7-12 

Male 13-19 

Female 13-19/ NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1- 2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Page 11of1 2 

Tot al Exposure 

mg/kg 

body wt/day 

0 . 003711 

0.004248 

0 . 003610 

0 . 003677 

0.003742 

0 . 003515 

0 . 00822 2 

0.003145 

0 . 012462 

0 . 004647 

0.002688 

0 . 002520 

0 . 002754 

0.002631 

0.002621 

0.006769 

0.002629 

0 . 016168 

0. 0 11083 

0.005226 

0 . 002605 

0. 002758 

0.002615 

0 . 002624 

Pe rcent of 

Rf d 

13. 7% 

15 . 7% 

13 .4 % 

13.6% 

13.9% 

13.0% 

30 .5% 

11 . 6% 

46.2% 

17. 2% 

10.0% 

9. 3% 

10 . 2% 

9 . 7% 

9 . 7% 

25 . 1% 

9 . 7% 

59.9% 

41.0% 

19 .4 % 

9 . 6% 

10.2% 

9. 7% 

9.7% 
Acequinocyl Dietary Exposure and Risk Assessment 0 431306 

Attachment 3: DEEM-FCID Chronic Exposure and Risk Estimates - Food Only 

us EPA Ver . 3.16, 03-08-d 

DEEM-FCID Chronic analysis for ACEQUINOCYL NHANES 2003 - 2008 2 - day 

Residue file name: C: \ Users\ gkramer\ OneDrive - Environmental Protection Agency 

(EPA)\Gk\$$Acequinocyl\006329C_Food Only.ROS 

Adjustment factor H2 used. 

Analysis Date 01-27-2016/14:02:52 Residue file dated : 01-27-2016/14:02:19 

Reference dose (RfD, Chronic) = .027 mg/ kg bw/ day 

COMMENT l: No acute dietary endpoint; not carcinogen. cRfD=cPAD 

Total exposure by population subgroup 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Ch i l dren 1 - 6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1 - 2 

Children 3 - 5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total Exposure 

mg/ kg 

body wt/day 

0.003571 

0. 004115 

0.003466 

0.003562 

0.003581 

0.003389 

0.007756 

0.003013 

0.012282 

0.004530 

0.002592 

0.002412 

0.002624 

0.002484 

0.002485 

0.006408 

0.002490 

0.015966 

0.010913 

0.005104 

0.002503 

0.002619 

0. 002477 

0.002485 

Page 12of 12 

Percent of 

Rfd 

13.2% 

15.2% 

12.8% 

13.2% 

13. 3% 

12.6% 

28. 7% 

11. 2% 

45 . 5% 

16.8% 

9 .6\ 

8.9% 

9 . 7% 

9.2% 

9.2% 

23. 7% 

9.2% 

59 .1% 

40 .4% 

18.9% 

9 .3% 

9.7% 

9.2% 

9.2%