Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 1 of 10 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES
AND TOXIC SUBSTANCES



### MEMORANDUM

August, 20, 2009

SUBJECT: Cyromazine – Chronic Dietary and Drinking Water Exposure and Risk
Assessment.

PC Code: 121301 DP Barcode: D359606
Decision No.: 402535 Registration No.: 100-654
Petition No.: PP8E7470 Regulatory Action: Section 3 Risk Assessment Type: Dietary Case No.:
TXR No.: NA CAS No: 66215-27-8
MRID No.: NA 40 CFR: 180.414



### FROM: Becky Daiss, Biologist
Risk Assessment Branch IV Health Effects Division (7509P)

THROUGH: Thurston Morton, Chemist Dietary Exposure Science Advisory Council (DESAC), Susan Hummel, Branch Senior Scientist, RAB IV Health Effects Division (7509P)

TO: Susan Stanton, Risk Manager
MUIRB Registration Division (7505P)

This document provides an acute and chronic di etary and drinking water risk analyses of exposures resulting from use of cyromazine on food crops for insect control. This assessment supports a Section 3 requests for use of cyromazine on succulent beans.Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 2 of 10 Executive Summary

A chronic dietary risk assessments was conducte d for cyromazine using the Dietary Exposure Evaluation Model (DEEM-FCID, Version 2.03), which uses food consumption data from the USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analysis was performed to support a Section 3 request for use of cyromazine on succulent
beans.

Acute Dietary Exposure Analysis Results and Characterization

There were no toxicological effects attributable to a single exposure (dose) of cyromazine observed in oral toxicity studies including the deve lopmental toxicity studies in rats or rabbits. Therefore, a dose and an endpoint for acute dietary exposure was not identified for cyromazine and an acute aggregate exposure assessment is not required.

Chronic Dietary Exposure Analysis Results and Characterization

A conservative chronic dietary exposure analysis was performed for the general U.S. population and various population subgroups. Tolerance level residues and 100 crop treated assumptions were used. DEEM default and empirical processi ng factors were used to modify the tolerance values. The chronic analysis incorporated the 10 year average surface drinking water estimate from application of cyromazine to succulent bean crop. Chronic dietary risk estimates are not of concern for general population or other population subgroups. The subgroup with the highest risk estimate was children 1-2 years old with a cPAD of 85%. The cPAD for the general U.S. population was 50%.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the Reference Dose (RfD) divided by the FQPA Safety Factor.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk
exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf ; or see SOP 99.6 (8/20/99).Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 3 of 10 II. Residue Information

Residues of Concern

The metabolism of cyromazine has been studied in celery, head lettuce, and tomatoes. The residue of concern is the parent compound cyromazine as determined by the HED Metabolism Assessment Review Committee (MARC) (D245214, 11/4/97). The metabolism of cyromazine in plants is adequately understood and additional plant metabolism data are not required for this proposed use on bean, succulent. Data concerning the metabolism of cyromazine in lactating goats and laying hens have been previously submitted. The MARC determined that the residue of concern in livestock commodities is the parent compound, cyromazine (D245214, J.B. Stokes, 4/15/98).

Table 1: Summary of MARC Decisions for Cyromazine
Residues of Concern Matrix For Risk Assessment For Tolerance Expression
Plants
Livestock Rotational Crops Drinking Water Parent Only Parent Only



### Established/Recommended Tolerances

Tolerances are established (40 CFR §180.414) for residues of cyromazine in or on a variety of commodities ranging from 0.05 ppm (livestock commodities) to 10.0 ppm (brassica vegetables). Recommended tolerances for the proposed new use is as follows.

Bean, succulent ........................................................ 2.0 ppm

Residues Used in the Chronic Analysis

For the chronic dietary analysis, tolerance level residues and 100% crop treated assumptions were used for all treated commodities. Default processing factors were used for all processed commodities. Residues used in the chronic dietary analysis are provided in Table 2.

Table 2. Residue Estimates Used in the Cyroma zine Chronic Dietary and Drinking Water Analysis Commodity Tolerance (ppm) Brassica vegetables (except broccoli) 10.0 Cucurbit vegetables 1.0
Broccoli 1.0 Leafy vegetables (except Brassica ) 7.0 Cotton, undelinted seed 0.1 1

Garlic 0.2
Leek 3.0
Lima bean 1.0 Mango 0.3 2Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 4 of 10 Table 2. Residue Estimates Used in the Cyroma zine Chronic Dietary and Drinking Water Analysis Commodity Tolerance (ppm)
Mushroom 1.0 Onion, bulb 0.2 Onion, green 3.0 Pepper 1.0
Potato 0.8
Tomato 0.5 Sweet corn (kernel plus cob with husks removed) 0.5 1

Succulent bean 2.0 Radish roots and tops 0.5 1 Turnip, greens 10.0
Milk 0.05
Meat 0.05
Fat 0.05 Meat byproduct (except kidney) 0.05 Kidney 0.2 Eggs 0.25 Poultry meat, fat and meat byproducts 0.05

1 Indirect or inadvertent residues.

2 There are no U.S. registrations on mango as of May 4, 2000.



### III. Water Data

Drinking water residues were incorporated directly into the chronic dietary analysis (“water, direct, all sources” and “water, indirect, all s ources”) and were provided by the Environmental Fate and Effects Division (EFED; D358724, J Wolf , 7/6/09). EFED generated the surface water and ground water estimates using the Tier 1 surface water FQPA Index Reservoir Screening
Tool (FIRST) and Screening Concentration in Ground Water (SCIGROW; Tier 1) models, respectively. EFED provided estimates for the proposed use of cyromazine on succulent beans using the Tier 1 FIRST applied as 6 applications at (0.125 lb ai/ac) rates, and a seasonal rate of 0.75 lb ai/acre. The concentrations have been adjusted with the Percent Crop Area (PCA) of 0.87 for a national assessment. Surface water EDWCs for cyromazine used in the exposure assessment, are provided in Table 3. Acute and chronic exposure concentrations of cyromazine in ground water are estimated using SCI-GROW which considers the additional fate information (Koc = 99.6 mL/g oc 

### and mean ASM half-life of 104 days).

Table 3. EDWCs for use in screening th e Cyromazine Health Risk Assessment Drinking Water Source Peak ( μ g/L) Annual Mean ( μ g/L)
Surface Water 47.1 15.8
Ground Water 1.1 1.1



### IV. DEEM-FCIDTM Program and Consumption Information

Cyromazine chronic dietary exposure assessmen ts were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCIDTM, Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of FoodCyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 5 of 10 Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form. The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

HED evaluated the toxicology data base for cyromazine and selected doses and endpoints for chronic dietary and drinking water risk assessments provided in Table 4.

Table 4. Summary of Toxicological Doses and Endpoints fo r Cyromazine for Use in Dietary Human Health Risk
Assessments

Exposure/
Scenario POD Uncertainty/FQ PA Safety

Factors RfD, PAD, LOC
for Risk
Assessment Study and Toxicological Effects

Chronic Dietary (all populations) NOAEL=
1.5 mg/kg/day UF A = 10x
UF H =10x FQPA SF= 1x Chronic RfD =
0.015 mg/kg/day
cPAD = 0.015 mg/kg/day Combined Chronic/Carcinogenicity Toxicity in Rats. LOAEL = 15 mg/kg/day based on food consumption and body weight decreases at 15 mg/kg/day (LOAEL).
Cancer (all routes) Not likely human carcinogen

Point of Departure (POD) = A data point or an estimated point th at is derived from observed dose -response data and used to mar k the beginning of extrapolation to determine risk associ ated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level.

NOAEL = no observed adverse effect level.
LOAEL = lowest observed adverse effect level. UF = uncertainty factor.
UF A = extrapolation from animal to human (interspecies).
UF H = potential variation in sensitivity among member s of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic).
RfD = reference dose.Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 6 of 10 VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Tables 5 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in Table 5.

Table 5: Summar y of Chronic Dietar y Ex p osure and Risk for C y romazine
Chronic Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD
General U.S. Po p ulation 0.0073 50
All Infants ( < 1 y ear old ) 0.0060 40
Children 1-2 y ears ol d 0.0127 85
Children 3-5 y ears ol d 0.0114 76
Children 6-12 y ears ol d 0.0081 54
Youth 13-19 y ears ol d 0.0060 40
Adults 20-49 y ears ol d 0.0066 44
Adults 50+ y ears ol d 0.0073 49
Females 13-49 y ears ol d 0.015

0.0065 43



### VII. Conclusions

Chronic dietary exposure analyses were perfor med for the general U.S. population and various population subgroups. The risk estimates for the general U.S. population and all population subgroups are below HED’s level of concern. HED is confident that chronic dietary exposures to cyromazine are not underestimated.

VIII. List of Attachments

1. Acute DEEM-FCID Residue Input File. 2. Results of Acute DEEM-FCID Dietary Exposure Analysis. 3. Chronic DEEM-FCID Residue Input File. 4. Results of Chronic DEEM-FCID Dietary Exposure Analysis.Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 7 of 10 Attachment 1 Chronic DEEM-FCID Residue Input File

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for CYROMAZINE 1994-98 data Residue file: C:\Documents and Settings\rdaiss\My Documents\Cyromazine\cyromazine061903-8-

18-09wWater&Beans.R98 Adjust. #2 used Analysis Date 08-18-2009 Residue file dated: 08-18-2009/09:45:08/8 Reference dose (RfD) = 0.015 mg/kg bw/day

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 04010050 4A Amaranth, leafy 7.000000 1.000 1.000 04010180 4A Arugula 7.000000 1.000 1.000 09020210 9B Balsam pear 1.000000 1.000 1.000 06030300 6C Bean, black, seed 3.000000 1.000 1.000 06020310 6B Bean, broad, succulent 2.000000 1.000 1.000 06020330 6B Bean, cowpea, succulent 2.000000 1.000 1.000 06020370 6B Bean, lima, succulent 2.000000 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.050000 1.000 1.000 21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 21000480 M Beef, kidney 0.200000 1.000 1.000 21000490 M Beef, liver 0.050000 1.000 1.000 21000491 M Beef, liver-babyfood 0.050000 1.000 1.000 95000540 O Belgium endive 7.000000 1.000 1.000 05010610 5A Broccoli 1.000000 1.000 1.000 05010611 5A Broccoli-babyfood 1.000000 1.000 1.000 05010620 5A Broccoli, Chinese 10.000000 1.000 1.000 05020630 5B Broccoli raab 10.000000 1.000 1.000 05010640 5A Brussels sprouts 10.000000 1.000 1.000 05010690 5A Cabbage 10.000000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 10.000000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 10.000000 1.000 1.000 09010750 9A Cantaloupe 1.000000 1.000 1.000
04020760 4B Cardoon 7.000000 1.000 1.000
09010800 9A Casaba 1.000000 1.000 1.000 05010830 5A Cauliflower 10.000000 1.000 1.000 04020850 4B Celery 7.000000 1.000 1.000 04020851 4B Celery-babyfood 7.000000 1.000 1.000 04020860 4B Celery, juice 7.000000 1.000 1.000
04020870 4B Celtuce 7.000000 1.000 1.000 09020880 9B Chayote, fruit 1.000000 1.000 1.000 40000930 P Chicken, meat 0.050000 1.000 1.000 40000931 P Chicken, meat-babyfood 0.050000 1.000 1.000 40000940 P Chicken, liver 0.050000 1.000 1.000 40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 40000951 P Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 40000960 P Chicken, fat 0.050000 1.000 1.000 40000961 P Chicken, fat-babyfood 0.050000 1.000 1.000 40000970 P Chicken, skin 0.050000 1.000 1.000 40000971 P Chicken, skin-babyfood 0.050000 1.000 1.000 02001010 2 Chicory, tops 7.000000 1.000 1.000 09021020 9B Chinese waxgourd 1.000000 1.000 1.000 04011040 4A Chrysanthemum, garland 7.000000 1.000 1.000
05021170 5B Collards 10.000000 1.000 1.000 15001270 15 Corn, sweet 0.500000 1.000 1.000 15001271 15 Corn, sweet-babyfood 0.500000 1.000 1.000Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 8 of 10 95001280 O Cottonseed, oil 0.100000 1.000 1.000 95001281 O Cottonseed, oil-babyfood 0.100000 1.000 1.000 04011330 4A Cress, garden 7.000000 1.000 1.000 04011340 4A Cress, upland 7.000000 1.000 1.000
09021350 9B Cucumber 1.000000 1.000 1.000 04011380 4A Dandelion, leaves 7.000000 1.000 1.000 70001450 P Egg, whole 0.250000 1.000 1.000 70001451 P Egg, whole-babyfood 0.250000 1.000 1.000 70001460 P Egg, white 0.250000 1.000 1.000 70001470 P Egg, yolk 0.250000 1.000 1.000 70001471 P Egg, yolk-babyfood 0.250000 1.000 1.000 04011500 4A Endive 7.000000 1.000 1.000 04021520 4B Fennel, Florence 7.000000 1.000 1.000 03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.050000 1.000 1.000 23001720 M Goat, kidney 0.200000 1.000 1.000 23001730 M Goat, liver 0.050000 1.000 1.000 06031820 6C Guar, seed 3.000000 1.000 1.000 09011870 9A Honeydew melon 1.000000 1.000 1.000 24001890 M Horse, meat 0.050000 1.000 1.000
05021940 5B Kale 10.000000 1.000 1.000 05011960 5A Kohlrabi 10.000000 1.000 1.000
03001980 3 Leek 3.000000 1.000 1.000 06032030 6C Lentil, seed 3.000000 1.000 1.000 04012040 4A Lettuce, head 7.000000 1.000 1.000 04012050 4A Lettuce, leaf 7.000000 1.000 1.000 95002150 O Mango 0.300000 1.000 1.000 95002151 O Mango-babyfood 0.300000 1.000 1.000 95002160 O Mango, dried 0.300000 1.000 1.000 95002170 O Mango, juice 0.300000 1.000 1.000 95002171 O Mango, juice-babyfood 0.300000 1.000 1.000 27002220 D Milk, fat 0.050000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 27012230 D Milk, nonfat solids 0.050000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 27022240 D Milk, water 0.050000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000
95002280 O Mushroom 1.000000 1.000 1.000 05022290 5B Mustard greens 10.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 3.000000 1.000 1.000 04012480 4A Parsley, leaves 7.000000 1.000 1.000 19012490 19A Parsley, dried leaves 7.000000 1.000 1.000 19012491 19A Parsley, dried leaves-babyfood 7.000000 1.000 1.000 06022550 6B Pea, succulent 2.000000 1.000 1.000 06022551 6B Pea, succulent-babyfood 2.000000 1.000 1.000 06032560 6C Pea, dry 3.000000 1.000 1.000 06032561 6C Pea, dry-babyfood 3.000000 1.000 1.000 06022590 6B Pea, pigeon, succulent 2.000000 1.000 1.000 08002700 8 Pepper, bell 1.000000 1.000 1.000 08002701 8 Pepper, bell-babyfood 1.000000 1.000 1.000 08002710 8 Pepper, bell, dried 1.000000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 1.000000 1.000 1.000 08002720 8 Pepper, nonbell 1.000000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 1.000000 1.000 1.000 08002730 8 Pepper, nonbell, dried 1.000000 1.000 1.000 25002900 M Pork, meat 0.050000 1.000 1.000 25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.050000 1.000 1.000Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 9 of 10 25002920 M Pork, meat byproducts 0.050000 1.000 1.000 25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 25002930 M Pork, fat 0.050000 1.000 1.000 25002931 M Pork, fat-babyfood 0.050000 1.000 1.000 25002940 M Pork, kidney 0.200000 1.000 1.000 25002950 M Pork, liver 0.050000 1.000 1.000 01032960 1C Potato, chips 0.800000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.800000 6.500 1.000 01032971 1C Potato, dry (granules/ flakes)-b 0.800000 6.500 1.000 01032980 1C Potato, flour 0.800000 1.000 1.000 01032981 1C Potato, flour-babyfood 0.800000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.800000 1.000 1.000 01032991 1C Potato, tuber, w/peel-babyfood 0.800000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.800000 1.000 1.000 01033001 1C Potato, tuber, w/o peel-babyfood 0.800000 1.000 1.000 60003010 P Poultry, other, meat 0.050000 1.000 1.000 60003020 P Poultry, other, liver 0.050000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 60003040 P Poultry, other, fat 0.050000 1.000 1.000 60003050 P Poultry, other, skin 0.050000 1.000 1.000 09023080 9B Pumpkin 1.000000 1.000 1.000 09023090 9B Pumpkin, seed 1.000000 1.000 1.000 04013130 4A Radicchio 7.000000 1.000 1.000 01013140 1AB Radish, roots 0.500000 1.000 1.000 05023180 5B Rape greens 10.000000 1.000 1.000
04023220 4B Rhubarb 7.000000 1.000 1.000
03003380 3 Shallot 0.200000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.050000 1.000 1.000 26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 26003420 M Sheep, kidney 0.200000 1.000 1.000 26003430 M Sheep, liver 0.050000 1.000 1.000 04013550 4A Spinach 7.000000 1.000 1.000 04013551 4A Spinach-babyfood 7.000000 1.000 1.000 09023560 9B Squash, summer 1.000000 1.000 1.000 09023561 9B Squash, summer-babyfood 1.000000 1.000 1.000 09023570 9B Squash, winter 1.000000 1.000 1.000 09023571 9B Squash, winter-babyfood 1.000000 1.000 1.000 04023670 4B Swiss chard 7.000000 1.000 1.000 08003740 8 Tomatillo 0.500000 1.000 1.000
08003750 8 Tomato 0.500000 1.000 1.000 08003751 8 Tomato-babyfood 0.500000 1.000 1.000 08003760 8 Tomato, paste 0.500000 5.400 1.000 08003761 8 Tomato, paste-babyfood 0.500000 5.400 1.000 08003770 8 Tomato, puree 0.500000 3.300 1.000 08003771 8 Tomato, puree-babyfood 0.500000 3.300 1.000 08003780 8 Tomato, dried 0.500000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.500000 14.300 1.000 08003790 8 Tomato, juice 0.500000 1.500 1.000 50003820 P Turkey, meat 0.050000 1.000 1.000 50003821 P Turkey, meat-babyfood 0.050000 1.000 1.000 50003830 P Turkey, liver 0.050000 1.000 1.000 50003831 P Turkey, liver-babyfood 0.050000 1.000 1.000 50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 50003841 P Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 50003850 P Turkey, fat 0.050000 1.000 1.000 50003851 P Turkey, fat-babyfood 0.050000 1.000 1.000 50003860 P Turkey, skin 0.050000 1.000 1.000 50003861 P Turkey, skin-babyfood 0.050000 1.000 1.000 05023890 5B Turnip, greens 10.000000 1.000 1.000 86010000 O Water, direct, all sources 0.015800 1.000 1.000 86020000 O Water, indirect, all sources 0.015800 1.000 1.000
09013990 9A Watermelon 1.000000 1.000 1.000 09014000 9A Watermelon, juice 1.000000 1.000 1.000Cyromazine (PC Code 121301) Dietary Exposure and Ri sk Assessment DP #: 359606



### Page 10 of 10 Attachment 2 Results of Chronic DEEM-FCID Dietary Exposure Analysis

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for CYROMAZINE (1994-98 data) Residue file name: C:\Documents and Settings\rdaiss\My Documents\Cyromazine\cyromazine061903-8-18-09wWater&Beans.R98 Adjustment factor #2 used. Analysis Date 08-18-2009/09:36:13 Residue file dated: 08-18-2009/09:35:04/8 Reference dose (RfD, Chronic) = .015 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.007266 48.4%

U.S. Population (spring season) 0.007400 49.3% U.S. Population (summer season) 0.007483 49.9% U.S. Population (autumn season) 0.007104 47.4% U.S. Population (winter season) 0.007074 47.2%

Northeast region 0.007368 49.1% Midwest region 0.007281 48.5% Southern region 0.006925 46.2% Western region 0.007698 51.3%

Hispanics 0.007029 46.9% Non-hispanic whites 0.006996 46.6% Non-hispanic blacks 0.007849 52.3% Non-hisp/non-white/non-black 0.010596 70.6%

All infants (< 1 year) 0.006071 40.5% Nursing infants 0.002694 18.0% Non-nursing infants 0.007353 49.0% Children 1-6 yrs 0.011564 77.1% Children 7-12 yrs 0.007741 51.6%

Females 13-19 (not preg or nursing) 0.005611 37.4% Females 20+ (not preg or nursing) 0.006956 46.4% Females 13-50 yrs 0.006583 43.9% Females 13+ (preg/not nursing) 0.005833 38.9% Females 13+ (nursing) 0.007264 48.4%

Males 13-19 yrs 0.006377 42.5% Males 20+ yrs 0.006719 44.8% Seniors 55+ 0.007240 48.3%

Children 1-2 yrs 0.012696 84.6% Children 3-5 yrs 0.011383 75.9% Children 6-12 yrs 0.008061 53.7% Youth 13-19 yrs 0.006011 40.1% Adults 20-49 yrs 0.006581 43.9% Adults 50+ yrs 0.007278 48.5% Females 13-49 yrs 0.006450 43.0%