Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 1 of 10 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

MEMORANDUM 

August, 20, 2009 

SUBJECT: Cyromazine – Chronic Dietary and Drinking Water Exposure and Risk 

Assessment. 

PC Code: 121301 DP Barcode: D359606 

Decision No.: 402535 Registration No.: 100-654 

Petition No.: PP8E7470 Regulatory Action: Section 3 

Risk Assessment Type: Dietary Case No.: 

TXR No.: NA CAS No: 66215-27-8 

MRID No.: NA 40 CFR: 180.414

FROM: Becky Daiss, Biologist 

Risk Assessment Branch IV 

Health Effects Division (7509P) 

THROUGH: Thurston Morton, Chemist 

 Dietary Exposure Science Advisory Council (DESAC), 

 Susan Hummel, Branch Senior Scientist, RAB IV

Health Effects Division (7509P) 

TO: Susan Stanton, Risk Manager 

 MUIRB 

 Registration Division (7505P) 

This document provides an acute and chronic dietary and drinking water risk analyses of 

exposures resulting from use of cyromazine on food crops for insect control. This assessment 

supports a Section 3 requests for use of cyromazine on succulent beans. 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 2 of 10 

Executive Summary

A chronic dietary risk assessments was conducted for cyromazine using the Dietary Exposure 

Evaluation Model (DEEM-FCID, Version 2.03), which uses food consumption data from the 

USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. 

 The analysis was performed to support a Section 3 request for use of cyromazine on succulent 

beans. 

 

Acute Dietary Exposure Analysis Results and Characterization

There were no toxicological effects attributable to a single exposure (dose) of cyromazine 

observed in oral toxicity studies including the developmental toxicity studies in rats or rabbits. 

Therefore, a dose and an endpoint for acute dietary exposure was not identified for cyromazine 

and an acute aggregate exposure assessment is not required.

Chronic Dietary Exposure Analysis Results and Characterization

A conservative chronic dietary exposure analysis was performed for the general U.S. population 

and various population subgroups. Tolerance level residues and 100 crop treated assumptions 

were used. DEEM default and empirical processing factors were used to modify the tolerance 

values. The chronic analysis incorporated the 10 year average surface drinking water estimate 

from application of cyromazine to succulent bean crop. Chronic dietary risk estimates are not of 

concern for general population or other population subgroups. The subgroup with the highest 

risk estimate was children 1-2 years old with a cPAD of 85%. The cPAD for the general U.S. 

population was 50%. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

Reference Dose (RfD) divided by the FQPA Safety Factor. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf ; or see SOP 99.6 

(8/20/99). 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 3 of 10 

II. Residue Information

Residues of Concern 

The metabolism of cyromazine has been studied in celery, head lettuce, and tomatoes. The 

residue of concern is the parent compound cyromazine as determined by the HED Metabolism 

Assessment Review Committee (MARC) (D245214, 11/4/97). The metabolism of cyromazine 

in plants is adequately understood and additional plant metabolism data are not required for this 

proposed use on bean, succulent. Data concerning the metabolism of cyromazine in lactating 

goats and laying hens have been previously submitted. The MARC determined that the residue 

of concern in livestock commodities is the parent compound, cyromazine (D245214, J.B. Stokes, 

4/15/98). 

Table 1: Summary of MARC Decisions for Cyromazine

Residues of Concern Matrix For Risk Assessment For Tolerance Expression 

Plants 

Livestock 

Rotational Crops 

Drinking Water 

Parent Only Parent Only 

Established/Recommended Tolerances

Tolerances are established (40 CFR §180.414) for residues of cyromazine in or on a variety of 

commodities ranging from 0.05 ppm (livestock commodities) to 10.0 ppm (brassica vegetables). 

 Recommended tolerances for the proposed new use is as follows. 

Bean, succulent ........................................................ 2.0 ppm 

Residues Used in the Chronic Analysis

For the chronic dietary analysis, tolerance level residues and 100% crop treated assumptions 

were used for all treated commodities. Default processing factors were used for all processed 

commodities. Residues used in the chronic dietary analysis are provided in Table 2. 

Table 2. Residue Estimates Used in the Cyromazine Chronic Dietary and Drinking Water Analysis

Commodity Tolerance (ppm) 

Brassica vegetables (except broccoli) 10.0 

Cucurbit vegetables 1.0 

Broccoli 1.0 

Leafy vegetables (except Brassica) 7.0 

Cotton, undelinted seed 0.1 1

Garlic 0.2 

Leek 3.0 

Lima bean 1.0 

Mango 0.3 2
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 4 of 10 

Table 2. Residue Estimates Used in the Cyromazine Chronic Dietary and Drinking Water Analysis

Commodity Tolerance (ppm) 

Mushroom 1.0 

Onion, bulb 0.2 

Onion, green 3.0 

Pepper 1.0 

Potato 0.8 

Tomato 0.5 

Sweet corn (kernel plus cob with husks removed) 0.5 1

Succulent bean 2.0 

Radish roots and tops 0.5 1

Turnip, greens 10.0 

Milk 0.05 

Meat 0.05 

Fat 0.05 

Meat byproduct (except kidney) 0.05 

Kidney 0.2 

Eggs 0.25 

Poultry meat, fat and meat byproducts 0.05 

1 Indirect or inadvertent residues. 

2

 There are no U.S. registrations on mango as of May 4, 2000. 

III. Water Data 

Drinking water residues were incorporated directly into the chronic dietary analysis (“water, 

direct, all sources” and “water, indirect, all sources”) and were provided by the Environmental 

Fate and Effects Division (EFED; D358724, J Wolf, 7/6/09). EFED generated the surface water 

and ground water estimates using the Tier 1 surface water FQPA Index Reservoir Screening 

Tool (FIRST) and Screening Concentration in Ground Water (SCIGROW; Tier 1) models, 

respectively. EFED provided estimates for the proposed use of cyromazine on succulent beans 

using the Tier 1 FIRST applied as 6 applications at (0.125 lb ai/ac) rates, and a seasonal rate of 

0.75 lb ai/acre. The concentrations have been adjusted with the Percent Crop Area (PCA) of 

0.87 for a national assessment. Surface water EDWCs for cyromazine used in the exposure 

assessment, are provided in Table 3. Acute and chronic exposure concentrations of cyromazine 

in ground water are estimated using SCI-GROW which considers the additional fate information 

(Koc = 99.6 mL/goc and mean ASM half-life of 104 days). 

Table 3. EDWCs for use in screening the Cyromazine Health Risk Assessment 

Drinking Water Source Peak (μg/L) Annual Mean (μg/L)

Surface Water 47.1 15.8 

Ground Water 1.1 1.1 

IV. DEEM-FCIDTM Program and Consumption Information

Cyromazine chronic dietary exposure assessments were conducted using the Dietary Exposure 

Evaluation Model software with the Food Commodity Intake Database (DEEM-FCIDTM, 

Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 5 of 10 

Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the 

reported consumption of more than 20,000 individuals over two non-consecutive survey days. 

Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, 

peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using 

publicly available recipe translation files developed jointly by USDA/ARS and EPA. For 

chronic exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups, but for acute exposure assessment are retained as individual 

consumption events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took 

into account dietary patterns and survey respondents, HED concluded that it is most appropriate 

to report risk for the following population subgroups: the general U.S. population, all infants (<1 

year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, 

and adults 50+ years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup. 

V. Toxicological Information

HED evaluated the toxicology data base for cyromazine and selected doses and endpoints for 

chronic dietary and drinking water risk assessments provided in Table 4. 

Table 4. Summary of Toxicological Doses and Endpoints for Cyromazine for Use in Dietary Human Health Risk 

Assessments 

Exposure/ 

Scenario POD 

Uncertainty/FQ

PA Safety 

Factors 

RfD, PAD, LOC 

for Risk 

Assessment 

Study and Toxicological Effects 

Chronic Dietary 

(all populations) 

NOAEL=

1.5 

mg/kg/day 

UFA= 10x 

UFH=10x 

FQPA SF= 1x 

Chronic RfD = 

0.015 

mg/kg/day 

cPAD = 0.015 

mg/kg/day 

Combined Chronic/Carcinogenicity 

Toxicity in Rats. 

LOAEL = 15 mg/kg/day based on food 

consumption and body weight decreases 

at 15 mg/kg/day (LOAEL). 

Cancer 

(all routes) 

Not likely human carcinogen 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning 

of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. 

 

NOAEL = no observed adverse effect level. 

LOAEL = lowest observed adverse effect level. 

UF = uncertainty factor. 

UFA = extrapolation from animal to human (interspecies). 

UFH = potential variation in sensitivity among members of the human population (intraspecies). 

FQPA SF = FQPA Safety Factor. 

PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 6 of 10 

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Tables 5 are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in Table 5. 

Table 5: Summary of Chronic Dietary Exposure and Risk for Cyromazine

Chronic Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD 

General U.S. Population 0.0073 50 

All Infants (< 1 year old) 0.0060 40 

Children 1-2 years old 0.0127 85 

Children 3-5 years old 0.0114 76 

Children 6-12 years old 0.0081 54 

Youth 13-19 years old 0.0060 40 

Adults 20-49 years old 0.0066 44 

Adults 50+ years old 0.0073 49 

Females 13-49 years old

0.015 

0.0065 43 

VII. Conclusions

Chronic dietary exposure analyses were performed for the general U.S. population and various 

population subgroups. The risk estimates for the general U.S. population and all population 

subgroups are below HED’s level of concern. HED is confident that chronic dietary exposures 

to cyromazine are not underestimated. 

VIII. List of Attachments

1. Acute DEEM-FCID Residue Input File. 

2. Results of Acute DEEM-FCID Dietary Exposure Analysis. 

3. Chronic DEEM-FCID Residue Input File. 

4. Results of Chronic DEEM-FCID Dietary Exposure Analysis. 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 7 of 10 

Attachment 1 Chronic DEEM-FCID Residue Input File 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for CYROMAZINE 1994-98 data 

Residue file: C:\Documents and Settings\rdaiss\My Documents\Cyromazine\cyromazine061903-8-

18-09wWater&Beans.R98 

 Adjust. #2 used 

Analysis Date 08-18-2009 Residue file dated: 08-18-2009/09:45:08/8 

Reference dose (RfD) = 0.015 mg/kg bw/day 

-------------------------------------------------------------------------------- 

Food Crop Residue Adj.Factors Comment 

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

04010050 4A Amaranth, leafy 7.000000 1.000 1.000 

04010180 4A Arugula 7.000000 1.000 1.000 

09020210 9B Balsam pear 1.000000 1.000 1.000 

06030300 6C Bean, black, seed 3.000000 1.000 1.000 

06020310 6B Bean, broad, succulent 2.000000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 2.000000 1.000 1.000 

06020370 6B Bean, lima, succulent 2.000000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.050000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 

21000480 M Beef, kidney 0.200000 1.000 1.000 

21000490 M Beef, liver 0.050000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.050000 1.000 1.000 

95000540 O Belgium endive 7.000000 1.000 1.000 

05010610 5A Broccoli 1.000000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.000000 1.000 1.000 

05010620 5A Broccoli, Chinese 10.000000 1.000 1.000 

05020630 5B Broccoli raab 10.000000 1.000 1.000 

05010640 5A Brussels sprouts 10.000000 1.000 1.000 

05010690 5A Cabbage 10.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 10.000000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 10.000000 1.000 1.000 

09010750 9A Cantaloupe 1.000000 1.000 1.000 

04020760 4B Cardoon 7.000000 1.000 1.000 

09010800 9A Casaba 1.000000 1.000 1.000 

05010830 5A Cauliflower 10.000000 1.000 1.000 

04020850 4B Celery 7.000000 1.000 1.000 

04020851 4B Celery-babyfood 7.000000 1.000 1.000 

04020860 4B Celery, juice 7.000000 1.000 1.000 

04020870 4B Celtuce 7.000000 1.000 1.000 

09020880 9B Chayote, fruit 1.000000 1.000 1.000 

40000930 P Chicken, meat 0.050000 1.000 1.000 

40000931 P Chicken, meat-babyfood 0.050000 1.000 1.000 

40000940 P Chicken, liver 0.050000 1.000 1.000 

40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 

40000951 P Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 

40000960 P Chicken, fat 0.050000 1.000 1.000 

40000961 P Chicken, fat-babyfood 0.050000 1.000 1.000 

40000970 P Chicken, skin 0.050000 1.000 1.000 

40000971 P Chicken, skin-babyfood 0.050000 1.000 1.000 

02001010 2 Chicory, tops 7.000000 1.000 1.000 

09021020 9B Chinese waxgourd 1.000000 1.000 1.000 

04011040 4A Chrysanthemum, garland 7.000000 1.000 1.000 

05021170 5B Collards 10.000000 1.000 1.000 

15001270 15 Corn, sweet 0.500000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.500000 1.000 1.000 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 8 of 10 

95001280 O Cottonseed, oil 0.100000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.100000 1.000 1.000 

04011330 4A Cress, garden 7.000000 1.000 1.000 

04011340 4A Cress, upland 7.000000 1.000 1.000 

09021350 9B Cucumber 1.000000 1.000 1.000 

04011380 4A Dandelion, leaves 7.000000 1.000 1.000 

70001450 P Egg, whole 0.250000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.250000 1.000 1.000 

70001460 P Egg, white 0.250000 1.000 1.000 

70001470 P Egg, yolk 0.250000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.250000 1.000 1.000 

04011500 4A Endive 7.000000 1.000 1.000 

04021520 4B Fennel, Florence 7.000000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.050000 1.000 1.000 

23001720 M Goat, kidney 0.200000 1.000 1.000 

23001730 M Goat, liver 0.050000 1.000 1.000 

06031820 6C Guar, seed 3.000000 1.000 1.000 

09011870 9A Honeydew melon 1.000000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

05021940 5B Kale 10.000000 1.000 1.000 

05011960 5A Kohlrabi 10.000000 1.000 1.000 

03001980 3 Leek 3.000000 1.000 1.000 

06032030 6C Lentil, seed 3.000000 1.000 1.000 

04012040 4A Lettuce, head 7.000000 1.000 1.000 

04012050 4A Lettuce, leaf 7.000000 1.000 1.000 

95002150 O Mango 0.300000 1.000 1.000 

95002151 O Mango-babyfood 0.300000 1.000 1.000 

95002160 O Mango, dried 0.300000 1.000 1.000 

95002170 O Mango, juice 0.300000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.300000 1.000 1.000 

27002220 D Milk, fat 0.050000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 

27012230 D Milk, nonfat solids 0.050000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

27022240 D Milk, water 0.050000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

95002280 O Mushroom 1.000000 1.000 1.000 

05022290 5B Mustard greens 10.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 3.000000 1.000 1.000 

04012480 4A Parsley, leaves 7.000000 1.000 1.000 

19012490 19A Parsley, dried leaves 7.000000 1.000 1.000 

19012491 19A Parsley, dried leaves-babyfood 7.000000 1.000 1.000 

06022550 6B Pea, succulent 2.000000 1.000 1.000 

06022551 6B Pea, succulent-babyfood 2.000000 1.000 1.000 

06032560 6C Pea, dry 3.000000 1.000 1.000 

06032561 6C Pea, dry-babyfood 3.000000 1.000 1.000 

06022590 6B Pea, pigeon, succulent 2.000000 1.000 1.000 

08002700 8 Pepper, bell 1.000000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 1.000000 1.000 1.000 

08002710 8 Pepper, bell, dried 1.000000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

08002720 8 Pepper, nonbell 1.000000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 1.000000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 1.000000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.050000 1.000 1.000 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 9 of 10 

25002920 M Pork, meat byproducts 0.050000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

25002930 M Pork, fat 0.050000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.050000 1.000 1.000 

25002940 M Pork, kidney 0.200000 1.000 1.000 

25002950 M Pork, liver 0.050000 1.000 1.000 

01032960 1C Potato, chips 0.800000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.800000 6.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.800000 6.500 1.000 

01032980 1C Potato, flour 0.800000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.800000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.800000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.800000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.800000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.800000 1.000 1.000 

60003010 P Poultry, other, meat 0.050000 1.000 1.000 

60003020 P Poultry, other, liver 0.050000 1.000 1.000 

60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 

60003040 P Poultry, other, fat 0.050000 1.000 1.000 

60003050 P Poultry, other, skin 0.050000 1.000 1.000 

09023080 9B Pumpkin 1.000000 1.000 1.000 

09023090 9B Pumpkin, seed 1.000000 1.000 1.000 

04013130 4A Radicchio 7.000000 1.000 1.000 

01013140 1AB Radish, roots 0.500000 1.000 1.000 

05023180 5B Rape greens 10.000000 1.000 1.000 

04023220 4B Rhubarb 7.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.050000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 

26003420 M Sheep, kidney 0.200000 1.000 1.000 

26003430 M Sheep, liver 0.050000 1.000 1.000 

04013550 4A Spinach 7.000000 1.000 1.000 

04013551 4A Spinach-babyfood 7.000000 1.000 1.000 

09023560 9B Squash, summer 1.000000 1.000 1.000 

09023561 9B Squash, summer-babyfood 1.000000 1.000 1.000 

09023570 9B Squash, winter 1.000000 1.000 1.000 

09023571 9B Squash, winter-babyfood 1.000000 1.000 1.000 

04023670 4B Swiss chard 7.000000 1.000 1.000 

08003740 8 Tomatillo 0.500000 1.000 1.000 

08003750 8 Tomato 0.500000 1.000 1.000 

08003751 8 Tomato-babyfood 0.500000 1.000 1.000 

08003760 8 Tomato, paste 0.500000 5.400 1.000 

08003761 8 Tomato, paste-babyfood 0.500000 5.400 1.000 

08003770 8 Tomato, puree 0.500000 3.300 1.000 

08003771 8 Tomato, puree-babyfood 0.500000 3.300 1.000 

08003780 8 Tomato, dried 0.500000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.500000 14.300 1.000 

08003790 8 Tomato, juice 0.500000 1.500 1.000 

50003820 P Turkey, meat 0.050000 1.000 1.000 

50003821 P Turkey, meat-babyfood 0.050000 1.000 1.000 

50003830 P Turkey, liver 0.050000 1.000 1.000 

50003831 P Turkey, liver-babyfood 0.050000 1.000 1.000 

50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 

50003841 P Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 

50003850 P Turkey, fat 0.050000 1.000 1.000 

50003851 P Turkey, fat-babyfood 0.050000 1.000 1.000 

50003860 P Turkey, skin 0.050000 1.000 1.000 

50003861 P Turkey, skin-babyfood 0.050000 1.000 1.000 

05023890 5B Turnip, greens 10.000000 1.000 1.000 

86010000 O Water, direct, all sources 0.015800 1.000 1.000 

86020000 O Water, indirect, all sources 0.015800 1.000 1.000 

09013990 9A Watermelon 1.000000 1.000 1.000 

09014000 9A Watermelon, juice 1.000000 1.000 1.000 
Cyromazine (PC Code 121301) Dietary Exposure and Risk Assessment DP #: 359606

Page 10 of 10 

Attachment 2 Results of Chronic DEEM-FCID Dietary Exposure Analysis 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for CYROMAZINE (1994-98 data) 

Residue file name: C:\Documents and Settings\rdaiss\My 

Documents\Cyromazine\cyromazine061903-8-18-09wWater&Beans.R98 

 Adjustment factor #2 used. 

Analysis Date 08-18-2009/09:36:13 Residue file dated: 08-18-2009/09:35:04/8 

Reference dose (RfD, Chronic) = .015 mg/kg bw/day 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.007266 48.4% 

U.S. Population (spring season) 0.007400 49.3% 

U.S. Population (summer season) 0.007483 49.9% 

U.S. Population (autumn season) 0.007104 47.4% 

U.S. Population (winter season) 0.007074 47.2% 

Northeast region 0.007368 49.1% 

Midwest region 0.007281 48.5% 

Southern region 0.006925 46.2% 

Western region 0.007698 51.3% 

Hispanics 0.007029 46.9% 

Non-hispanic whites 0.006996 46.6% 

Non-hispanic blacks 0.007849 52.3% 

Non-hisp/non-white/non-black 0.010596 70.6% 

All infants (< 1 year) 0.006071 40.5% 

Nursing infants 0.002694 18.0% 

Non-nursing infants 0.007353 49.0% 

Children 1-6 yrs 0.011564 77.1% 

Children 7-12 yrs 0.007741 51.6% 

Females 13-19 (not preg or nursing) 0.005611 37.4% 

Females 20+ (not preg or nursing) 0.006956 46.4% 

Females 13-50 yrs 0.006583 43.9% 

Females 13+ (preg/not nursing) 0.005833 38.9% 

Females 13+ (nursing) 0.007264 48.4% 

Males 13-19 yrs 0.006377 42.5% 

Males 20+ yrs 0.006719 44.8% 

Seniors 55+ 0.007240 48.3% 

Children 1-2 yrs 0.012696 84.6% 

Children 3-5 yrs 0.011383 75.9% 

Children 6-12 yrs 0.008061 53.7% 

Youth 13-19 yrs 0.006011 40.1% 

Adults 20-49 yrs 0.006581 43.9% 

Adults 50+ yrs 0.007278 48.5% 

Females 13-49 yrs 0.006450 43.0%