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               1997 Stock Option Plan Form of Stock Option Agreement.


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                     SPIROS DEVELOPMENT CORPORATION II, INC.
                             STOCK OPTION AGREEMENT

RECITALS

     A.   The Board has adopted the Plan for the purpose of retaining the
services of selected Employees, non-employee members of the Board or of the
board of directors of any Parent or Subsidiary and consultants and other
independent advisors who provide services to the Corporation (or any Parent
or Subsidiary).

     B.   Optionee is to render valuable services to the Corporation (or a
Parent or Subsidiary), and this Agreement is executed pursuant to, and is
intended to carry out the purposes of, the Plan in connection with the
Corporation's grant of an option to Optionee.

     C.   All capitalized terms in this Agreement shall have the meaning
assigned to them in the attached Appendix.

          NOW, THEREFORE, it is hereby agreed as follows:

          1.   GRANT OF OPTION.  The Corporation hereby grants to Optionee,
as of the Grant Date, an option to purchase up to the number of Option Shares
specified in the Grant Notice.  The Option Shares shall be purchasable from
time to time during the option term specified in Paragraph 2 at the Exercise
Price.

          2.   OPTION TERM.  This option shall have a maximum term of ten
(10) years measured from the Grant Date and shall accordingly expire at the
close of business on the Expiration Date, unless sooner terminated in
accordance with Paragraph 5 or 6.

          3.   LIMITED TRANSFERABILITY.  This option shall be neither
transferable nor assignable by Optionee other than by will or by the laws of
descent and distribution following Optionee's death and may be exercised,
during Optionee's lifetime, only by Optionee.  However, if this option is
designated a Non-Statutory Option in the Grant Notice, then this option may,
in connection with the Optionee's estate plan, be assigned in whole or in
part during Optionee's lifetime to one or more members of the Optionee's
immediate family or to a trust established for the exclusive benefit of one
or more such family members.  The assigned portion shall be exercisable only
by the person or persons who acquire a proprietary interest in the option
pursuant to such assignment.  The terms applicable to the assigned portion
shall be the same as those in effect for this option immediately prior to
such assignment and shall be set forth in such documents issued to the
assignee as the Plan Administrator may deem appropriate.

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          4.   DATES OF EXERCISE.  This option shall become exercisable for
the Option Shares in one or more installments as specified in the Grant
Notice.  As the option becomes exercisable for such installments, those
installments shall accumulate, and the option shall remain exercisable for
the accumulated installments until the Expiration Date or sooner termination
of the option term under Paragraph 5 or 6.

          5.   CESSATION OF SERVICE.  The option term specified in Paragraph
2 shall terminate (and this option shall cease to be outstanding) prior to
the Expiration Date should any of the following provisions become applicable:

                      (i)     Should Optionee cease to remain in Service
     for any reason (other than death, Permanent Disability or Misconduct)
     while this option is outstanding, then the period during which this
     option may be exercised shall be limited to a three (3)-month period
     commencing with the date of such cessation of Service.  In no event,
     however, shall this option be exercisable at any time after the
     Expiration Date.

                     (ii)     Should Optionee dies while holding this
     option, then the personal representative of Optionee's estate or the
     person or persons to whom the option is transferred pursuant to
     Optionee's will or in accordance with the laws of descent and
     distribution shall have the right to exercise this option.  Such right
     shall lapse, and this option shall cease to be outstanding, upon the
     EARLIER of (A) the expiration of the twelve (12)-month period measured
     from the date of Optionee's death or (B) the Expiration Date.

                    (iii)     Should Optionee cease Service by reason of
     Permanent Disability while this option is outstanding, then the period
     during which this option may be exercised shall be limited to twelve
     (12)-month period commencing with the date of such cessation of
     Service.  In no event, however, shall this option be exercisable at
     any time after the Expiration Date.

                     (iv)     During the limited period of post-Service
     exercisability, this option may not be exercised in the aggregate for
     more than the number of Option Shares for which the option is
     exercisable at the time of Optionee's cessation of Service.  Upon the
     expiration of such limited exercise period or (if earlier) upon the
     Expiration Date, this option shall terminate and cease to be
     outstanding for any otherwise exercisable Option Shares for which the
     option has not been exercised.  However, this option shall,
     immediately upon Optionee's cessation of Service for any reason,
     terminate and cease to be outstanding with respect to any and all
     Option Shares for which this option is not otherwise at that time
     exercisable.

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                      (v)     Should Optionee's Service be terminated for
     Misconduct, then this option shall terminate immediately and cease to
     remain outstanding.

          6.   SPECIAL ACCELERATION OF OPTION.

               (a)  In the event of a Corporate Transaction, this option, to
the extent outstanding at that time, but not otherwise fully exercisable,
shall automatically accelerate so that this option shall, immediately prior
to the effective date of the Corporate Transaction, become exercisable for
all of the Option Shares at the time subject to this option and may be
exercised for any or all of those Option Shares as fully-vested shares of
Common Stock.  However, this option shall not become exercisable on such an
accelerated basis, if and to the extent: (i) this option is, in connection
with the Corporate Transaction, to be assumed by the successor corporation
(or parent thereof) or (ii) this option is to be replaced with a cash
incentive program of the successor corporation which preserves the spread
existing at the time of the Corporate Transaction on the Option Shares for
which this option is not otherwise at that time exercisable (the excess of
the Fair Market Value of those Option Shares over the aggregate Exercise
Price payable for such shares) and provides for subsequent pay-out in
accordance with the same option exercise/vesting schedule set forth in the
Grant Notice.

               (b)  Immediately following the Corporate Transaction, this
option shall terminate and cease to be outstanding, except to the extent
assumed by the successor corporation (or parent thereof) in connection with
the Corporate Transaction.

               (c)  If this option is assumed in connection with a Corporate
Transaction, then this option shall be appropriately adjusted, immediately
after such Corporate Transaction, to apply to the number and class of
securities which would have been issuable to Optionee in consummation of such
Corporate Transaction had the option been exercised immediately prior to such
Corporate Transaction, and appropriate adjustments shall also be made to the
Exercise Price, PROVIDED the aggregate Exercise Price shall remain the same.

               (d)  This option may also become exercisable on an accelerated
basis in accordance with the terms and conditions of any special addendum
attached to this Agreement.

               (e)  This Agreement shall not in any way affect the right of
the Corporation to adjust, reclassify, reorganize or otherwise change its
capital or business structure or to merge, consolidate, dissolve, liquidate
or sell or transfer all or any part of its business or assets.

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          7.   ADJUSTMENT IN OPTION SHARES.  Should any change be made to the
Common Stock by reason of any stock split, stock dividend, recapitalization,
combination of shares, exchange of shares or other change affecting the
outstanding Common Stock as a class without the Corporation's receipt of
consideration, appropriate adjustments shall be made to (i) the total number
and/or class of securities subject to this option and (ii) the Exercise Price
in order to reflect such change and thereby preclude a dilution or
enlargement of benefits hereunder.

          8.   STOCKHOLDER RIGHTS.  The holder of this option shall not have
any stockholder rights with respect to the Option Shares until such person
shall have exercised the option, paid the Exercise Price and become a holder
of record of the purchased shares.

          9.   MANNER OF EXERCISING OPTION.

               (a)  In order to exercise this option with respect to all or
any part of the Option Shares for which this option is at the time
exercisable, Optionee (or any other person or persons exercising the option)
must take the following actions:

                      (i)     Execute and deliver to the Corporation a
     Notice of Exercise for the Option Shares for which the option is
     exercised.

                     (ii)     Pay the aggregate Exercise Price for the
     purchased shares in one or more of the following forms:

                         (A)  cash or check made payable to the
          Corporation;

                         (B)  a promissory note payable to the Corporation,
          but only to the extent authorized by the Plan Administrator in
          accordance with Paragraph 13;

                         (C)  shares of Common Stock held by Optionee (or
          any other person or persons exercising the option) for the
          requisite period necessary to avoid a charge to the Corporation's
          earnings for financial reporting purposes and valued at Fair
          Market Value on the Exercise Date; or

                         (D)  through a special sale and remittance
          procedure pursuant to which Optionee (or any other person or
          persons exercising the option) shall concurrently provide
          irrevocable written instructions (I) to a Corporation-designated
          brokerage firm to effect the immediate sale of the purchased
          shares and remit to the Corporation, out of the sale proceeds
          available on the settlement date, sufficient funds to


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          cover the aggregate Exercise Price payable for the purchased
          shares plus all applicable Federal, state and local income and
          employment taxes required to be withheld by the Corporation by
          reason of such exercise and (II) to the Corporation to deliver the
          certificates for the purchased shares directly to such brokerage
          firm in order to complete the sale.

               Except to the extent the sale and remittance procedure is
          utilized in connection with the option exercise, payment of the
          Exercise Price must accompany the Notice of Exercise delivered to
          the Corporation in connection with the option exercise.

                    (iii)     Furnish to the Corporation appropriate
     documentation that the person or persons exercising the option (if
     other than Optionee) have the right to exercise this option.

                     (iv)     Make appropriate arrangements with the
     Corporation (or Parent or Subsidiary employing or retaining Optionee)
     for the satisfaction of all Federal, state and local income and
     employment tax withholding requirements applicable to the option
     exercise.

               (b)  As soon as practical after the Exercise Date, the
Corporation shall issue to or on behalf of Optionee (or any other person or
persons exercising this option) a certificate for the purchased Option
Shares, with the appropriate legends affixed thereto.

               (c)  In no event may this option be exercised for any
fractional shares.

          10.  COMPLIANCE WITH LAWS AND REGULATIONS.

               (a)  The exercise of this option and the issuance of the
Option Shares upon such exercise shall be subject to compliance by the
Corporation and Optionee with all applicable requirements of law relating
thereto and with all applicable regulations of any stock exchange (or the
Nasdaq National Market, if applicable) on which the Common Stock may be
listed for trading at the time of such exercise and issuance.

               (b)  The inability of the Corporation to obtain approval from
any regulatory body having authority deemed by the Corporation to be
necessary to the lawful issuance and sale of any Common Stock pursuant to
this option shall relieve the Corporation of any liability with respect to
the non-issuance or sale of the Common Stock as to which such approval shall
not have been obtained. The Corporation, however, shall use its best efforts
to obtain all such approvals.

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          11.  SUCCESSORS AND ASSIGNS.  Except to the extent otherwise
provided in Paragraphs 3 and 6, the provisions of this Agreement shall inure
to the benefit of, and be binding upon, the Corporation and its successors
and assigns and Optionee, Optionee's assigns and the legal representatives,
heirs and legatees of Optionee's estate.

          12.  NOTICES.  Any notice required to be given or delivered to the
Corporation under the terms of this Agreement shall be in writing and
addressed to the Corporation at its principal corporate offices.  Any notice
required to be given or delivered to Optionee shall be in writing and
addressed to Optionee at the address indicated below Optionee's signature
line on the Grant Notice. All notices shall be deemed effective upon personal
delivery or upon deposit in the U.S. mail, postage prepaid and properly
addressed to the party to be notified.

          13.  FINANCING.  The Plan Administrator may, in its absolute
discretion and without any obligation to do so, permit Optionee to pay the
Exercise Price for the purchased Option Shares by delivering a full-recourse
promissory note payable to the Corporation.  The terms of any such promissory
note (including the interest rate, the requirements for collateral and the
terms of repayment) shall be established by the Plan Administrator in its
sole discretion.

          14.  CONSTRUCTION.  This Agreement and the option evidenced hereby
are made and granted pursuant to the Plan and are in all respects limited by
and subject to the terms of the Plan.  All decisions of the Plan
Administrator with respect to any question or issue arising under the Plan or
this Agreement shall be conclusive and binding on all persons having an
interest in this option.

          15.  GOVERNING LAW.  The interpretation, performance and
enforcement of this Agreement shall be governed by the laws of the State of
California without resort to that State's conflict-of-laws rules.

          16.  EXCESS SHARES.  If the Option Shares covered by this Agreement
exceed, as of the Grant Date, the number of shares of Common Stock which may
without stockholder approval be issued under the Plan, then this option shall
be void with respect to those excess shares, unless stockholder approval of
an amendment sufficiently increasing the number of shares of Common Stock
issuable under the Plan is obtained in accordance with the provisions of the
Plan.

          17.  ADDITIONAL TERMS APPLICABLE TO AN INCENTIVE OPTION.  In the
event this option is designated an Incentive Option in the Grant Notice, the
following terms and conditions shall also apply to the grant:

                      (i)     This option shall cease to qualify for
     favorable tax treatment as an Incentive Option if (and to the extent)
     this option is exercised for one or more Option Shares: (A) more than
     three (3) months after the date

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     Optionee ceases to be an Employee for any reason other than death or
     Permanent Disability or (B) more than twelve (12) months after the date
     Optionee ceases to be an Employee by reason of Permanent Disability.

                     (ii)     No installment under this option shall
     qualify for favorable tax treatment as an Incentive Option if (and to
     the extent) the aggregate Fair Market Value (determined at the Grant
     Date) of the Common Stock for which such installment first becomes
     exercisable hereunder would, when added to the aggregate value
     (determined as of the respective date or dates of grant) of the Common
     Stock or other securities for which this option or any other Incentive
     Options granted to Optionee prior to the Grant Date (whether under the
     Plan or any other option plan of the Corporation or any Parent or
     Subsidiary) first become exercisable during the same calendar year,
     exceed One Hundred Thousand Dollars ($100,000) in the aggregate.
     Should such One Hundred Thousand Dollar ($100,000) limitation be
     exceeded in any calendar year, this option shall nevertheless become
     exercisable for the excess shares in such calendar year as a Non-
     Statutory Option.

                    (iii)     Should the exercisability of this option be
     accelerated upon a Corporate Transaction, then this option shall
     qualify for favorable tax treatment as an Incentive Option only to the
     extent the aggregate Fair Market Value (determined at the Grant Date)
     of the Common Stock for which this option first becomes exercisable in
     the calendar year in which the Corporate Transaction occurs does not,
     when added to the aggregate value (determined as of the respective
     date or dates of grant) of the Common Stock or other securities for
     which this option or one or more other Incentive Options granted to
     Optionee prior to the Grant Date (whether under the Plan or any other
     option plan of the Corporation or any Parent or Subsidiary) first
     become exercisable during the same calendar year, exceed One Hundred
     Thousand Dollars ($100,000) in the aggregate.  Should the applicable
     One Hundred Thousand Dollar ($100,000) limitation be exceeded in the
     calendar year of such Corporate Transaction, the option may
     nevertheless be exercised for the excess shares in such calendar year
     as a Non-Statutory Option.

                     (iv)     Should Optionee hold, in addition to this
     option, one or more other options to purchase Common Stock which
     become exercisable for the first time in the same calendar year as
     this option, then the foregoing limitations on the exercisability of
     such options as Incentive Options shall be applied on the basis of the
     order in which such options are granted.

          18.  LEAVE OF ABSENCE.  The following provisions shall apply upon
the Optionee's commencement of an authorized leave of absence:

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                      (i)     The exercise schedule in effect under the
     Grant Notice shall be frozen as of the first day of the authorized
     leave, and this option shall not become exercisable for any additional
     installments of the Option Shares during the period Optionee remains
     on such leave.

                     (ii)     Should Optionee resume active Employee status
     within sixty (60) days after the start date of the authorized leave,
     Optionee shall, for purposes of the exercise schedule set forth in the
     Grant Notice, receive Service credit for the entire period of such
     leave.  If Optionee does not resume active Employee status within such
     sixty (60)-day period, then no Service credit shall be given for the
     period of such leave.

                    (iii)     If the option is designated as an Incentive
     Option in the Grant Notice, then the following additional provision
     shall apply:

                         -    If the leave of absence continues for more
          than ninety (90) days, then this option shall automatically
          convert to a Non-Statutory Option under the Federal tax laws at
          the end of the three (3)-month period measured from the ninety-
          first (91st) day of such leave, unless the Optionee's
          reemployment rights are guaranteed by statute or by written
          agreement.  Following any such conversion of the option, all
          subsequent exercises of such option, whether effected before or
          after Optionee's return to active Employee status, shall result
          in an immediate taxable event, and the Corporation shall be
          required to collect from Optionee the Federal, state and local
          income and employment withholding taxes applicable to such
          exercise.

                     (iv)     In no event shall this option become
     exercisable for any additional Option Shares or otherwise remain
     outstanding if Optionee does not resume Employee status prior to the
     Expiration Date of the option term.


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                                    EXHIBIT I
                               NOTICE OF EXERCISE


          I hereby notify Spiros Development Corporation II, Inc. (the
"Corporation") that I elect to purchase____________ shares of the
Corporation's Common Stock (the "Purchased Shares") at the option exercise
price of $_____________ per share (the "Exercise Price") pursuant to that
certain option (the "Option") granted to me under the Corporation's 1997
Stock Incentive Plan on________________________, 199_.

          Concurrently with the delivery of this Exercise Notice to the
Corporation, I shall hereby pay to the Corporation the Exercise Price for the
Purchased Shares in accordance with the provisions of my agreement with the
Corporation (or other documents) evidencing the Option and shall deliver
whatever additional documents may be required by such agreement as a
condition for exercise.  Alternatively, I may utilize the special
broker-dealer sale and remittance procedure specified in my agreement to
effect payment of the Exercise Price.

                    , 199
--------------------     --
Date

                              --------------------------------------------
                              Optionee

                              Address:
                                      ------------------------------------


                              --------------------------------------------
Print name in exact manner
it is to appear on the
stock certificate:
                              --------------------------------------------

Address to which certificate
is to be sent, if different
from address above:
                              --------------------------------------------


                              --------------------------------------------

Social Security Number:
                              --------------------------------------------

Employee Number:
                              --------------------------------------------

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                                    APPENDIX

          The following definitions shall be in effect under the Agreement:

     A.   AGREEMENT shall mean this Stock Option Agreement.

     B.   BOARD shall mean the Corporation's Board of Directors.

     C.   CODE shall mean the Internal Revenue Code of 1986, as amended.

     D.   COMMON STOCK shall mean the Corporation's common stock.

     E.   CORPORATE TRANSACTION shall mean either of the following stockholder-
approved transactions to which the Corporation is a party:

       (i)     a merger or consolidation in which securities possessing
     more than fifty percent (50%) of the total combined voting power of
     the Corporation's outstanding securities are transferred to a person
     or persons different from the persons holding those securities
     immediately prior to such transaction, or

      (ii)     the sale, transfer or other disposition of all or
     substantially all of the Corporation's assets in complete liquidation
     or dissolution of the Corporation.

     F.   CORPORATION shall mean Spiros Development Corporation II, Inc., a
Delaware corporation.

     G.   EMPLOYEE shall mean an individual who is in the employ of the
Corporation (or any Parent or Subsidiary), subject to the control and
direction of the employer entity as to both the work to be performed and the
manner and method of performance.

     H.   EXERCISE DATE shall mean the date on which the option shall have
been exercised in accordance with Paragraph 9 of the Agreement.

     I.   EXERCISE PRICE shall mean the exercise price per share as specified
in the Grant Notice.

     J.   EXPIRATION DATE shall mean the date on which the option expires as
specified in the Grant Notice.


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     K.   FAIR MARKET VALUE per share of Common Stock on any relevant date
shall be determined in accordance with the following provisions:

       (i)     If the Common Stock is at the time traded on the Nasdaq
     National Market, then the Fair Market Value shall be the closing
     selling price per share of Common Stock on the date in question, as
     the price is reported by the National Association of Securities
     Dealers on the Nasdaq National Market or any successor system.  If
     there is no closing selling price for the Common Stock on the date in
     question, then the Fair Market Value shall be the closing selling
     price on the last preceding date for which such quotation exists.

      (ii)     If the Common Stock is at the time listed on any Stock
     Exchange, then the Fair Market Value shall be the closing selling
     price per share of Common Stock on the date in question on the Stock
     Exchange determined by the Plan Administrator to be the primary market
     for the Common Stock, as such price is officially quoted in the
     composite tape of transactions on such exchange.  If there is no
     closing selling price for the Common Stock on the date in question,
     then the Fair Market Value shall be the closing selling price on the
     last preceding date for which such quotation exists.

     L.   GRANT DATE shall mean the date of grant of the option as specified
in the Grant Notice.

     M.   GRANT NOTICE shall mean the Notice of Grant of Stock Option
accompanying the Agreement, pursuant to which Optionee has been informed of
the basic terms of the option evidenced hereby.

     N.   INCENTIVE OPTION shall mean an option which satisfies the
requirements of Code Section 422.

     O.   MISCONDUCT shall mean the commission of any act of fraud,
embezzlement or dishonesty by Optionee, any unauthorized use or disclosure by
Optionee of confidential information or trade secrets of the Corporation (or
any Parent or Subsidiary), or any other intentional misconduct by Optionee
adversely affecting the business or affairs of the Corporation (or any Parent
or Subsidiary) in a material manner.  The foregoing definition shall not be
deemed to be inclusive of all the acts or omissions which the Corporation (or
any Parent or Subsidiary) may consider as grounds for the dismissal or
discharge of Optionee or any other individual in the Service of the
Corporation (or any Parent or Subsidiary).

     P.   NON-STATUTORY OPTION shall mean an option not intended to satisfy
the requirements of Code Section 422.

     Q.   NOTICE OF EXERCISE shall mean the notice of exercise in the form
attached hereto as Exhibit I.


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     R.   OPTION SHARES shall mean the number of shares of Common Stock
subject to the option as specified in the Grant Notice.

     S.   OPTIONEE shall mean the person to whom the option is granted as
specified in the Grant Notice.

     T.   PARENT shall mean any corporation (other than the Corporation) in
an unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the
time of the determination, stock possessing fifty percent (50%) or more of
the total combined voting power of all classes of stock in one of the other
corporations in such chain.

     U.   PERMANENT DISABILITY shall mean the inability of Optionee to engage
in any substantial gainful activity by reason of any medically determinable
physical or mental impairment which is expected to result in death or has
lasted or can be expected to last for a continuous period of twelve (12)
months or more.

     V.   PLAN shall mean the Corporation's 1997 Stock Incentive Plan.

     W.   PLAN ADMINISTRATOR shall mean either the Board or a committee of
the Board acting in its administrative capacity under the Plan.

     X.   SERVICE shall mean the Optionee's performance of services for the
Corporation (or any Parent or Subsidiary) in the capacity of an Employee, a
non-employee member of the board of directors or a consultant or independent
advisor.

     Y.   STOCK EXCHANGE shall mean the American Stock Exchange or the New
York Stock Exchange.

     Z.   SUBSIDIARY shall mean any corporation (other than the Corporation)
in an unbroken chain of corporations beginning with the Corporation, provided
each corporation (other than the last corporation) in the unbroken chain
owns, at the time of the determination, stock possessing fifty percent (50%)
or more of the total combined voting power of all classes of stock in one of
the other corporations in such chain.


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