### UNITED STATES ENVIRONMENTAL PROTECTION AGENC Y WASHINGTON, 

### D

. C. 20460
OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

M EMORA N D U M
Date: Subj e ct: 22

- MAR

- 2016
A cequinoc y l. Chronic Aggregate Dietary (Food + Drinking Water) Exposure and R isk Assess m e nt fo r the Propose d In crease in the P e rm ane nt To lerance for Residues inion Hops.

P C Co de : 006329 D

ec is io n No

. : 50500 I Pet iti o n No.: 5F8364 T XR No.: NA OP No.: 0431306 Reg is tration No .: NA Reg ul at o ry Ac ti o n : Amend an Es tabli shed Tolerance CA S No.: 57960-19-7 MRID No.: NA
FROM:

THRO UG H : 40 C FR : § 180.599 George F

. Krame r, Ph .D., Se ni or Chemis t Risk Assessment Branch 1 (RAB l ) / H ealth Effects Div i sion (HE D ; 7509P)

Ideliz Negr6n

- Encarnaci6n, ?J:?rh

# Chemist~**L-** 11 

## /l

# ~ De nn is McNeilly , Che mi st

### ~ '1 ....__ 

## ft. _; v '-""'" '- D ietary Exposure Science Ad sory Council (D SAC) D (7509P)
and
Charles W. Smith Ill , Branch Chie RAB l / HED (7509 P)
TO : George F. Kramer , Ph .D., R isk Assessor RAB 1/HED (7509P)
and
Andrew Ertman/Venus Eagle , RM l Registration Di vision (RD; 7505P)
Executive Summary
A chronic aggregat e dietary (food +drinking wate r) exposure and ri sk assessme nt was conducted using the D ietary Exposure Eva luation Model (DEEM-FC ID , Ve rsion 3. 1 6) w h ic h uses 2003- 2008 food consump ti on data from the U.S. Department of Agricu lture's (USDA's) Nat ional Health and Nutrition Examination Survey , What We Eat i n America, (NHANES/ WWE IA). The
ana lysis was performed to suppor t a req uest to increase the exist i ng to l erance for residues of the insec t icide acequinocyl, 2-(acety loxy)-3

- dodecy l

- 1 ,4

- nap htha le ned i o n e, and i ts me tabo li te, 2- Page I of 12Acequinocyl Dietary Ex posure and Risk A ss essment 04 3 1306 

### dod ecy l- 3- hydroxy -1 ,4 -n ap hth oquinone , expressed as acequinocyl equivalents in/on hops from 4.0 ppm to 15 ppm. An acute di etary assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single dose was not id e ntifi ed ; t h erefo re , an acute reference dose (aRID) was not es tabli s he d

. A cancer dietary assessment was not co ndu cted because acequinocyl was classified as not likely to be carcinogenic to humans.
Chronic Dietary (Food+ Drinking Water) Exposure Results and C haracterization
Tolerance-level residues and 100 percent crop treated ( % CT) data were used in the chro ni c dietary assessment. DEEM ver. 7.81 default processing factors were u sed with the excep tion of tho s e for grape juice and raisins ( see " Residue Information " Section of this document for details). Fo r th e chronic dietary assess ment , the gene ral U.S

. populati o n and all population subgroups have risk estimates that are not of concern to H ED. The ch ro nic dietary risk e s timate for the U.S. population is 14 % of the c hronic population-adju sted dose (c PAD )

. Th e risk of the highest exposed population subgroup (children 1-2 years old) occupies 60% of the cPAD. The
use of anticipated residues (ARs) , e mpiric a l processing factors, and %CT would refine further HED ' s exposu re and risk estim ates; however , refinement i s not needed at this time.

I. I ntrod u cti on 

### Dietary risk assessment incorporates both ex po s ure and toxicity of a given pesticide. For acute and chro nic assessmen ts , the risk is expressed as a p ercentage of a maximum acceptable dose (i.e. , the dose which HED has concluded will re s ult in no unreasonable adverse health effects). This dose is referred to as the population-adjusted dose (PAD). The P AD is equ i vale nt to point of departure (POD , NOAEL , LOAEL , e.g
. ) divided by the r equ ired unc erta inty or safety fac tors.
For acute and non-cancer c hroni c exposures , HED is concerned w he n estimated dietary risk exceeds 100% of the PAD. HED is generally concerned when esti m ated cancer risk exceeds one in one million. Re fe re nce s which di sc u ss the acute and chronic risk assessments in more detail are availab le on the EPA/pesticides web si te: "Availab le Information on Assess in g Exposure from Pesticides , A User's Guide , " 2 l-JUN- 2000 , web link: http: //www.regu lati ons.gov/ contentStreamer ? document Id = EPA -HQ-0PP-2007-07 80- 0001 &disposition = attachment&co nt e ntT ype=pdf; or see SOP 99.6 (20-AUG- 1999 ).
The most recent dietary risk assessment for aceq uino cyl was conducted by Sarah Levy (30

- NOV-201 l; D38999).

II . Resi d ue I nformation


### Unde r petition number 5F8364 , Arysta Li feScie nce is requ es tin g t o increase the ex ist in g tolerance for residues of the insecticide acequinocyl and its metabolite , 2-dodecy l- 3-hydroxy1 ,4-nap hthoquinon e , expressed as acequinocyl equivalents, in / on hop s from 4.0 ppm to 1 5 ppm
. The purpose of the amended tolerance is t o harmonize the va lu e to the established maximum residue limit 

### ( MRL) in the European Union (EU).
Permanent tolerances are c urrentl y established und er 40CFR§180.599(a) for the combined residues of acequinocyl and its metabolite , acequinocyl -OH , expressed as acequinocyl Page 2of12Accq uino cy l Di etary Expos ure and Ri sk Assess ment D4 3 1306



### e qui vale nt s, in / o n a numb er of p lant and li vestock commodities. To le ranc es for plant commodit ies range from 0.02 ppm (t r ee nut s and pistachios) to 30 ppm (c itru s o il ) , and to l erances fo r livestock commodi tie s are established at 0.02 ppm in th e fat and li ve r of ca ttl e, goat, hor se , and s h eep.

Tab le l. Re s idu es o f Co nce rn in C rops , Ruminant s, a nd Orin kin e Water. Matrix Tolerance Expression Re s idues for Risk A s sessment Fruit Crop s, Acequinocyl + Acequi nocy l- O H (R I) Aceq uin ocyl + Acequinocyl-OH ( RI ) Hops Ruminants Acequinocyl + Acequinoc yl-OH (RI) Acequinocyl + Acequinocyl-OH (RI). In liver and kidney, also include AKM-15. Rotational Crops Not Determined* N ot Determin ed* Drinkin g Water NA** Acequinocyl + Acequinocyl-OH (RI)
• A confined rota t ional crop s tudy ha s been reviewed and a JO-day pl ant-back interval has been r ecommended (Memo , S. Le vy, 25- J UN

- 2008; DP# 35 13 36). **NA = not applicable.


### Residue Data u se d for the C hronic Assessmen t :
To le ran ce-leve l residues a nd 1 00 %C T were u se d in the chron ic di e tary assess me nt. D EEM ver. 7.8 1 default processing fac tors we r e u sed with the excep ti on of those fo r grape jui ce and raisins. As residues we re reduced in both g rap e juice ( < 0.02X) and raisin 

### (O

. I 5X), separate to lera nces a r

e not req uire d for the se commod iti es. The DEEM ve r. 7.81 default proc ess in g fac tor s fo r jui ce and ra isi n we re set to I as co ncentrati on was shown not to occur (Memo, S. Levy , 05 -S EP-2007; D342805).

Fis h: The USDA Pesticide D ata Program (P DP) monitored pestic i de residues in catfis h in 2008 , 2009, and 20 I 0. In genera l, pes tic i de res idu es would not b e ex p ec te d to b e found in fish unles s th e pesticide bioaccumulates o r has an aq uati c u se. To determine w h e the r or not res idu es a re present in fish, HED now routine ly checks PDP monito rin g d ata regardless of the pes ticid e's
u ses and physicochemical prop e rtie s
. However, PDP did not anal yze ca tfi s h samp les for acequinocyl. As a result , residues in fish were not in cluded in the assessme nt.



### Ill. Drinking Water Data
The drinking water residues used in the d ietary risk assess ment were provided by the E n v ironm e ntal Fa te and Effec t s Divis io n (EFED) (M. Low it, 07

- SE P- 201 1 ; D3895 2 0) and in corporat ed direct ly int o thi s dietary assessment. As ther e are no proposed or requested changes in the acequ in ocy l lab el associated with this act ion , a new drinking wa ter assess me nt ha s not b ee n p e r fo rmed

. Wate r residu es were incorporated directl y into D EEM -FC ID und e r the food catego ri es " water , direct , all sources" and "water, indirect , all sources." Acequinocyl can reach s urface water via s pray drift and le ss likely v ia runoff. Du e to it s high 

### Kd
va l ues it is expected to exhibit l ow mobility in so il and low potential to l eac h into gro und wate r. Once acequinocy l ha s e nte red su rface water, it i s not li kely to per s ist as it wi ll h ydro l yze to form hydroxy-acequinocyl (a lso known as R-1 )

. There are no drinking water monitoring data availabl e for acequinocyl or its metabol ite acequi nocyl -OH (Rl), the residues of co ncern. Ground water est imated drin ki ng water conce ntr a tion s (E DWCs) were ge nerate d for aceq uin ocy l u si ng th e Sc re e nin g Concentration in Page 3of12Acequinocyl Dietary Expos ure and Risk Assessment 0431306 

### Ground Water (SCI

- GROW) Model. Surface water EDWCs were generated usin g the P esticide Root Zo ne Model/Exposure Analysis Modeling System (PRZM/EXAMS) model fo r all proposed
uses except cranberry (cra nb erries are part of the low growing berries subgro up , l 3-07G). C ranb erry harvesting may in vo lve field floodi ng and PRZM/EX AMS is n o t currently parameterized to assess this type of scenario; th erefore , cranberry was ass esse d using the provi s ional cranberry model (note that s ince the provisional cranberry model only u ses a one year s imulation , the highest 30-year annual average concentration is not available for the cranberry scenario).
Similar to previous drinking wate r asse ss ments provided by EFED, two approaches we re u se d in performing the drinking wate r assessment for proposed acequinocyl uses. In 

### Approach # 1 , acequinocyl was con ser v atively assumed to be s table to all route s of degradation to account for the uncertainti es associated with the env ironmental fate data

. In 

### Approach # 2, total (acequinocyl 

### + acequinocyl-OH) res idues were mod e led with the assumption that the half-liv es of acequinocyl and R 1 are va lid and th e total tox ic residues were modeled to address toxicity con cerns with R 1. 

### The E DWC s are summarized below in Table 3. Surface water EDWCs for the propo se d u ses are higher th an th ose prev iou s ly reported for both approaches. The gro und water EDWC for the
curre nt assessme nt i s th e same as the la s t assessment.

Table 3. R eco mm e nd ed E OWC s of Acequ inoc y l Deri ve d from the Prev io u s Uses. E

DWCs from Surface Water Sources (ug/L)u llpproach I llpproach 2 Drinkin g wat er Proposed source (model) Usc/Sc cnario 3 (ass um e no accquinocyl degradation) (combi ned aceq uino cyl and RI ) l-in-1 0

- I -in- I0

-year year acute chronic Su r face water Cherry/M I cherry 6.69 6.69 (PRZM /E XAMS) (25.89) 4 ( 17

. 84)4 Sma ll fruit (vi ne Surface water climbing. except fuzzy 6.69 6.69 (PRZM/EXAMS) kiwifrnit, I3

- 07F)/NY (23. I2)J ( 15.34) 4 grape Surface water Cranbe r ry/Provisional ( Pro v isional 4.24 3.75 Cranb erry Model) Cranberry Model Groundwater All propo se d u ses 3

. 6 x 10· 3 5 3.6 x 1 0· 3 (SC IGRO\V)

1 B o ld ed valu es are the re comme nd ed E D WC s by EFED. 2 A default PCA of0 .87 was applied. 3 Maximum of2 applications of0.3 lb ai/ A for a ll propo se d uses. 30-year l-in

- 10- I-in- I0-year mean year acute chronic 6.69 5.59 0.42 ( I0.19) 4

6.69 4 .22 0.38 (9. 57) 4



### -- 3.81 5 1.36 5

::;3.6 x I

### o ·3 3

. 6 x 10· 3 5 3

. 6 x 10
· 3

4 ED WC (s ho wn in parentheses) exceeds th e solub ility limit of acequinocyl (6.69 μg/L a t 20°C); th erefore, the recommended EDWC is 6.69 ppb. 5 Based on a one-year s imulation ; 1-10 -year calculation i s not applicable. 30-ycar mean 0.26

0.27



### --
5 3.6 x 10 ·.1



### Since the su rface water EDW Cs are higher than the groundwater EDWC , HED selected th e surface water value for u se in th e chronic dietary assessment. The EDWC derived via Approac h # 1 represent s the upper-bound va lue (6.69 ppb) while th a t derived via Approach #2 repre se nt s the l owe r-bound value ( 1.36 ppb). The 6.69 ppb value was used in this dietary assessment as this value assures a conservative assessment.

IV. DEEM-FCID Program and Consumption Information
An 

### acequinocyl chron ic dietary exposure asses s ment was conducted usin g DE EM-FCID , Version 3 .1 6 , which incorporates 2003-2008 consumption data from USDA ' s Pa ge 4o f12Accquinoc yl Di etary Expo s ure and Ri sk Assessment D431306
N HAN ES /WWElA

. The data a re ba sed on the reporte d consumption of more than 20,000 individual s over two non-consecutive s urvey days. Foods "as consumed" (i.e., apple pie) a re link ed to E PA -d efi ned foo d co mmoditi es ( i. e., a pple s, peel ed fruit

- cooked ; fresh o r N / S; baked ; or w heat flour

- coo ked ; fresh or N/ S , baked) u s ing publicly ava il able recip e translation files developed joint ly by US D A/ ARS and E P A. For chronic exposure assessme nt , cons ump tio n data
a re ave rage d for the entire U.S. population and within popul ation subgroups , but fo r acute expos ure assess m e nt are re tain ed as individual co n sumption eve nts. Ba sed on analysis of the 2003

-2008 NHANES / WWEIA co n sump ti o n data , which took into acco unt dietary pattern s and s urvey respondents , HED conc luded that it i s most appropriate to re port ri s k for th e following p opu lat io n s ubgroups: the gen eral U.S. population , a ll infant s (<I ye ar old), c hildren l- 2 ye ars o ld, c hildre n 3-5 year s o ld , children 6-12 years old , yo uth 1 3- 19 years old , adults 20- 49 years old, females 1 3 -49 years o ld , and adult s 50-99 years o ld.
Fo r chronic diet a ry exposure assess m e nt , an est imate of th e residue leve l in eac h foo d or foo dfo rm (e .g. , o ran ge o r orange juice) on the food commod ity re s idue li s t is multiplied by th e average daily consumption estimate for that foo d /fo od form to produce a res idue intake estimate. The resulting residue int ake est imate for each food/food form is sum m ed wi th th e residue intake esti mate s for all o ther foo d / food forms o n the commod ity res idu e li s t to arrive at th e total average est imate d exposure
. Exposure is expressed in m g/kg body weight/day and as a p e rce nt of the c P A D. This procedure is performed for eac h population subgroup

.



### V. Toxico l ogica l Information
On 1 4 -0 C T

- 200 3, the HED Ha za rd Ident ifi cat io n Assess m e nt Rev iew Committee ( HI ARC) re viewed the recommendations of th e toxicology reviewer for ace quinoc yl with regard to th e acute and c hro ni c Rill s a nd the tox i colog ical e ndp o in t se le ct ion for use as approp ri ate in
occ upati ona l/resid e nti a l ex po s ure risk assess ments. The potential for in creased susceptibili ty of in fa nt s and c hildre n from ex po s ure to ace quinocyl was also evaluate d as r e quired b y the Food Quality Protection Ac t (F QPA) of 1 996 unde r the 2002 OPP 1 

### O

X Guidanc e. Table 4 is a s ummary of th e toxicology dos es and e ndpoint s se lected that a re re l ev ant to dietary ex p os ure assess m e nt ( 1 3-N OV- 2003; TXR # 0052234). The acequinocyl ri sk assess m ent team confirmed th at the e ndp o int s selected pre viousl y remain appropriate.

T ab le 4. S ummary o f To xico logica l Doses and Endpoints for Acequinocy l for Use in Di etary Expo s ure R isk A

ssess ment. 1 Ex pos ure / Point of Uncerta inty / RfD , PAD , Leve l of Study and Toxicological Eff ects Scenario Departure FQPA SFs Concern Acute Di etary An endpoint of concern (effec t ) (Ge neral attributable to a s in g le d ose was Popu lati on , not id entified in the database. including Quanti ti cation of ac ute ri sk to In fants and ge ne ral popu lation inclu din g Chi ldren ) infants and children is not required. Chronic NOAEL = UFA = IOX cPAD 

### = cRfD 

### = 18-mo nth carci noge nicit y study in Dietary 2.7 UF11 = IOX 0.027 mg/kg/day mice; (All mg/kg/day FQPA SF = IX LOA EL = 7.0 m g/kg/day based on Population s) clinical c hemi st ry and mi c ro scop ic non -n eop las ti c lesions (brown pigmented cells and p eriva sc ular inflammato ry ce ll s in liv er)

. Page 5 or 1 2Ace quin ocy l Di e t ary Ex pos ur e and Ri s k Assessment D43 1 306
Cancer (oral. dermal. inhalation) Classi fication : ··Not likely to be Carcinogenic to I luman s."
1 U F = un cer taint y factor. UFA = ex t rapo l ati on from a nim al t o hum an (i nt erspec i es), UF 11 = potent i al variation in se nsitivity among memb ers of the human popu lation (in t ras pecies), FQPA SF = FQ PA Safety Factor, NOAEL = noobserved adverse-efTect level. LOAEL =lowest-observed adverse

-effect level. RID = reference dose (a = acute

. c = chronic), PAD = population-adjusted dose. N IA = not app licable.



### VI. Result s /Discus s ion
As stated ab ove, for acute and c hronic assessments , HED is concerned w hen dietary risk exceeds 100 % of the PA D

. T he D EEM-FC ID ana lyses est imate th e dietary ex p osure of the U.S. popu l ation and various popul ati o n s ub groups
. The result s r e ported in Tabl e 5 are fo r the ge neral U.S. population , all in fants (<I-year old) , c hildre n 1-2 , children 3-5 , c hildre n 6 -1 2, yout h 1 3- 19 , females 13-4 9, ad ul ts 20 -49 , and adults 50+ years. An 

### acute dietary assessmen t was not conducted for ace quin ocy l be cau se an e ndpoint of concern attributab le to a s ingle dos e was n o t ident i fied; therefore, a n aRfD was no t es tab li s hed. A cancer dietary assessment was not conducted because acequinocyl was classified as not likely to be carc in oge ni c to humans.
The chronic die tary exposure as sess men t (us in g tolerance level residues and 100 % CT info rm at ion fo r all re g istered and prop osed u ses) was conduc ted fo r the general U.S. population and va ri o u s population s ubgroup s. Drinking wate r was incorporate d direc tl y into the di etary assessme nt usi n g the chronic conce ntrati on for ground wate r generated by the P RZM/EXAMS mod e l. T hi s assess me nt concludes th at the chronic dietary risk estima t es are not of co ncern to HED fo r the ge nera l U.S. popul ati o n ( 14% c PAD) and a ll popu lation subgroups. Th e mo s t highl y exposed population subgroup is c hildren 1-2 years old at 60% of the c P AD.

T a bl e 5. S u mmary o f Dietar y (Food + Drinkin g W a t er) Expo s ur e a nd Ri sk fo r Aceq uino cyl. C hronic Dietary 1 Population Subgroup Di etary Exposu re %c PAD (mg/kg/day) U.S. Population (tota l ) 0.003711 14 All Infants (<l year old) 0.006769 25 C hil dre n 1-2 vears old 0.016168 60 Children 3-5 years old 0.011083 41 Children 6

- 12 years old 0.005226 19 You t h 13- 19 years old 0.002605 10 Adu lt s 20-49 years o ld 0.002758 10 Adul ts 50 + years old 0.002615 10 Females 1 3 -4 9 years old 0.002624 10 1 Chronic dietary endpoint of 0.027 mg/kg/day applies t o the ge n era l U.S. population and all popu l ation subgroups. The va lu es for the highest exposed population are bolded.



### V II. C h arac te riz at i on of Input s/ Outputs
The c hronic a nalysi s ass umed to leran ce- leve l r es idues and 100 %CT data. DEEM ver. 7.81 default proce ssi ng factors were used with the exception of tho se for grape ju ice and raisins. This analysis is consider ed ve ry conservative and could be refined through th e u se of A R s for all commoditi es, %CT data for r egistered commodities , and/o r additional e mpirical pro cess in g factors.

Page 6of 12Acequinocyl Di etary Exposure and Ri sk Assessment 0431306

VIII. Conclusions
A c h ronic di etary exposure and ri s k assess ment was conducted fo r the proposed permanent toler a nce for res idu es of acequ in ocy l , includin g potential ex po s ure from drinkin g water.
The chronic dietary (food+ drinking wate r) expos ure to acequi n ocy l is below H E D 's leve l of
concern fo r the ge ner a l U.S

. popu lat io n a nd a ll pop ul at io n subgroups. Th e c hroni c dietary ri s k utilized 14 % cPAD fo r the general U.S. population and 60% of the cPAD for children 1 -2 years old , the m ost highly exposed population s ub gro up. An ac ute dietary assessment was not conducted fo r ace quin ocy l b eca u se an e ndpoint of concern att ri butable to a s in g le dose was not identified; therefore, an aRID was not established. A cancer dietary assessment was not conducted because aceq uin ocyl was classi fi ed as no t likely to be carc ino ge nic to human s.

IX. List of Attachments
Attachment I: Chronic Food + Drinkin g Water Residue Input Fil e. Attachme nt 2: C hro ni c R esults File. Attachment 3 : Chronic Re s ult s (Food o nl y) File

ROI: DESAC (27-JAN-2016) G.F. Kra mer: S I0957: PY- S:(703)305-5079:7509 P:RAB I

Page 7 of 12Acequinoc y l Di e tary Expos ure a nd Ri s k Assess ment 04 3 1306 Attachment 1: Chronic Food + Drinking Water Re s idue Input Fi le.
F ilename : C : \Users\gkramer\ On e Drive

- Environmental Protection Agency ( EPA) \Gk\ $$ Acequi nocy l \006 329C.ROS Chemical : Acequinocyl RfD(Chro nic): .027 mg/kg bw/day NOEL(Ch ronic) : 2.7 mg/kg bw/day RfD(Acute): O mg/kg bw/day NO EL( Acute) : O mg/kg bw /day Date created/last modified : 06-lS-2015/13:32 : 43 Program ver
. 3.16, 03

- 0S-d Commen t : N o ac ute dietary endpoint ; n o t carcinogen. cRfD=cPAD

Crop EPA Code Grp Commodity Nam e Def Res (pp m)
9500177000 0 9500 178000 0 95001SSOOO 0 0602031000 6B 060 2033 000 6B 0602037000 6B 0601043000 6A 0601043001 6A 060134950 0 GAB OS0214SOOO SBC OS0 2234 000 SBC OS02270000 SB OS02271000 SB 080 2271001 SB OS02270001 SB OS0 22 72000 SBC OS02273000 SBC OS0227200 1 SBC OS01374000 SA OS01375000 SA OS0 1378 000 SA 080137S001 SA OS01379000 SA OS0 1376 000 SA OS0 137 600 1 SA OS01377000 SA OS0137700 1 SA OS0 13 7500 1 SA 0901075000 9A 0902135000 9B 090 11 S7000 9A 0901399000 9A 0901400000 9A 100 11 06000 lOA 100110700 0 lOA lOOllOSOOO lOA 1003180000 lOC 1003 1 Sl000 lOC 100 2197000 lOB 1002199000 lOB 1002200000 lOB 100 2200001 lOB 1002201000 lOB 1002206000 lOB 1002207000 lOB 100 2 207001 lOB 1001240000 lOA 1001241000 lO A 1 00 1241 00 1 lOA 100 124 2000 lOA 1003307000 lOC 1001369000 lOA 1001370000 lOA 110 000 9000 11 1100009001 11 1100007000 11 110001000 0 11 Grape, leaves Grape, rais in H

op Bean, broad, succulent Bean, cowpea, succulent Bean, lima , succulent Bean, snap, succu l ent Bean, snap, succulent-babyfood Soybean, vegetable Eggplant Okra Pepper , bell Pepper , bell, dried Pepper, bell, dried-babyfood Pepper, bell-babyfood Peppe r, nonbell Pepper, nonbell, dried Pepper, nonbell

- babyfood T omat il lo Tomato Tomato, dried T omato , dried- babyfo od Tomato, juice Tomato , paste Tomato, pa ste

- babyfood Tomato, puree Tomato, puree-babyfood Tomato-baby fo od Cantaloupe cucumber H

oneydew melon W

ate rmelon Watermel on , juic e Citron Citrus hybrid s Citrus, oil Grape f ruit Grapefruit , juice Kumquat Lemon Lemon, juice Lemo n, juice-babyfood Lemon, peel Lime Lime, juice Lime, juice

- babyfood Ora nge Orange , ju ice Orange, j uice-babyfood Ora nge, peel Pummelo Tangerine Tangerine, Juice Apple, dr ied A

pple, dried

- babyfood Apple, fruit with peel Apple, juice 1.6 00000 1.6 00000 15.0 00000 0

. 250000 0.250000 0

. 250000 0

. 250000 0.250000 0.250000 0

. 700000 0.700000 0.700000 0

. 700000 0

. 700000 0

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. 700000 0.7 00000 0

. 700000 0.700000 0

. 700000 0

. 700000 0.700000 0

. 700000 0

. 700000 0

. 700000 0.700000 0.700000 0

. 150000 0

. 150000 0.150000 0.150000 0.150000 0

. 200000 0.200000 30. 000000

0

. 200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0

. 200000 0.200000 0.200000 0

. 200000 0.200000 0.200000 0

. 200000 0

. 200000 0

. 200000 0.200000 0.400000 0.400000 0

. 400000 0

. 400000 Page 8of12 Adj.Factors #1 #2
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9E759S 1E7864 1E7864 1E7S64 9E7598 9E759S 1E7S64 9E759S 9E759S 9E7598 9E759S 9E759S 9E759S 9E759S 9E759S 9E759S 9E7598 9E7598 9E759S 9E759S 9E759S 9E7598 9E759S 9E7598 9E7598 9E7598 1E7S6 4 1E7S6 4 1E 7S6 4 1E 7S64 1E7S64Acequinocyl

1100010001 11 1100008000 11 1100008001 ll 1100011000 ll 1100011001 ll 1100129000 11 1100210000 11 1100266000 11 1100267000 11 1100268000 11 1100268001 11 110026600 1 ll 1100310000 ll 1201090000 12A 1201091000 12A 1201091001 l2A 1201090001 12A 1301055000 13A 1301056000 13A 1301056001 13A 1302057000 13B 1302057001 13B 1301058000 l3A 1307130000 13G 1307131000 13G 1307132000 13G 1307132001 13G 1307130001 l3G 1304175000 130 1304176000 130 1304176001 130 1304179000 130 1304195000 130 1301208000 13A 1301320000 13A 1301321000 13A 1301321001 13A 1301320001 13A 1307359000 13G 1307360000 13G 1307360001 13G 1307359001 13G 1400003000 14 1400004000 14 1400004001 14 1400003001 14 1400059000 14 1400068000 14 1400081000 14 1400092000 14 1400155000 l4 1400156000 14 1400185000 l4 1400213000 14 1400269000 14 1400282000 14 1400391000 14 3100047000 31 3100047001 31 3100048000 31 3100049000 31 3100049001 31 3100046000 31 3100046001 31 3200171000 32 3200172000 32 3200173000 32 3500341000 35 3500341001 35 3500342000 35 3500343000 35 Di e tary Exposure and Ri sk Assess m ent Apple, juice-babyfood Apple, peeled fruit Appl e, peeled fruit-babyfood Apple, sauce Apple. sauce-babyfood Crabapple Loqu at Pear Pear, dried Pear, juice Pear, juice-babyfood Pea r-baby f ood Quince Cherry Cherry, juice Cherry, j uice-babyfood Cherry-babyfood Blackberry Blackberry, juice Blackberry, juice

- babyfood Blueberry Blueberry-babyfood Boysenberry Cranberry Cranberry, dried Cranberry, juice Cranberry, juice-babyfood Cranberry-babyfoo d Grape Grape, juice Grape, juice-babyfood Grape , wine and sher ry K

iw ifruit, fuzzy Loganberry Raspberry Raspberry, juice Raspberry , juice-babyfoo d Raspberry-baby food Strawberry Strawberry, juice Strawberry, juic e-babyfood Strawberry-babyfood Almond Almond, oil Alm ond , oil-babyfood Almond-babyfood Brazil nut Butternut Cashew Chestnut Hazelnut Hazelnut, oil Hickory nut Macadamia nut Pecan Pistachio Walnut Beef, fat Beef, fat-babyfood Beef, kidney Beef, liver Be ef, liver-babyfood Beef, meat byproducts Beef, meat byproducts-babyfood Goat, fat Goat , kidney Goat, liver Sheep, fat 0 .400000 0.400000 0.400000 0.400000 0.400000 0 .4 00000 0.400000 0.400000 0.400000 0.400000 0.400000 0.400000 0

. 400000 l. 000000 l.000000 l.000000 1.000000 4.000000 4.000000 4.000000 0

. 500000 0.500000 4.000000 0.500000 0.500000 0.500000 0

. 500000 0.500000 l. 600000 l.600000 l. 600000 1.600000 1.600000 4.000000 4.000000 4.000000 4.000000 4.000000 0.500000 0.500000 0.500000 0

. 500000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0

. 020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 0.020000 Sheep, fat-babyfood Sheep, kidney She ep , liver 0.020000 Page 9of 12 l.300 1.000 l.000 1.000 1.000 1.000 1. 000 1. 000 1

. 000 1

. 000 l.000 l.000 l. 000 l. 000 1.000 1.000 6.250 1. 000 l.000 l. 000 1.000 1

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. 000 1.000 1

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. 000 1.000 1. 000 1. 000 1.000 1.000 1 .000 1.000 l.000 l. 000 1 .000 1.000 1. 000 l. 000 1 .000 l. 000 1.000 1.000 l. 000 l. 000 1

. 000 1.000 1.000 l. 000 l.000 1.000 l.000 1.000 l. 000 1.000 1.000 l.000 l .000 1.000 1.000 1. 000 l

. 000 l. 000 l.000 l. 000 1

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. 000 1.000 l.000 l.000 l.000 l. 000 l. 000 l. 000 l. 000 1.000 l.000 1.000 l.000 l.000 l.000 l. 000 l. 000 l. 000 l. 000 l. 000 l. 000 1.000 1.000 l.000 l.000 l. 000 l. 000 1

. 000 l.000 l.000 l.000 1. 000 l. 000 1.000 1

. 000 l. 000 l. 000 l.000 1.000 1.000 1.000 04 3 1306

1E7864 1E7864 1E7864 1E7864 1E7864 lE7864 1E7864

1E7864 1E7864 lE7864 1E7864 1E7864 lE7864

1E7864 1E7864 1E7864 1E7864 1E7864 1E7864 lE7864 lE7864 1E7864 1E7864Aceq uin ocy l Di e t ary Ex po s ure and Ri s k Assess m e nt 04 3 1306

35003 4 0000 35 Sheep, meat byproduccs 8601000000 86A w ater, direcc, all sources 8602000000 86 B w acer, indirect, all source s 0

. 020000 0

. 006690 0.006690

Page 1 0of 12 1. 000 1.000 1

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. 000 1E7864Acequinocyl Di e t ary Exposure and Risk Assessment
A tta chm e nt 2: C hro nic Re s ults Fil e.
US EPA DEEM

- FCID Chronic an aly s is for ACEQUINO CYL 2008 2-day 0431306

Ver

. 3

. 16, 03-08-d NHANES 2003-
Residue file name: C : \Users\gkramer\OneDrive

- Agency (EPA)\Gk\$$Acequinocyl\006329C

. R08 Env i ronmental Pro tec tion Adjustment factor #2 used. Analysis Date 0 1 -21 -2 016/12 : 41 : 41 2016/12 : 41 : 08 Residue fi le dated: 01-21-
Reference dose (RfD, Chronic) = . 027 mg /kg bw /day COMMENT 1 : No acute dietary endpo int ; not carcinogen. cRfD=cPAD



### =============== == ========================== = ==== == ==== == ==== = ==== == ======= Total exposure by populatio n subgroup

Population

Subgroup
Total US Population Hispanic Non-Hisp-White Non- Hisp-Black Non-Hisp-Other Nursing Inf ants Non-Nursi ng In fa nts Female 13+ PREG Children 1-6 Chil d ren 7-12 Male 13-19 Female 13-19 / NP Male 20+ Female 20 + /NP Seniors 55+ All Inf an ts Female 13-50 Children 1- 2 Children 3-5 Children 6-12 Youth 13-19 Adults 20-49 Adults 50-99 Female 13-49

Page 1 1of1 2 To t al Exposure mg/kg body wt/day
0

. 003711 0.004248 0

. 003610 0

. 00 367 7 0.003742 0

. 003515 0

. 00 822 2 0.003145 0

. 012462 0

. 004647 0.002688 0

. 002520 0

. 002 754 0.002631 0.002621 0.006769 0.002629 0

. 016168 0. 0 1108 3 0.005226 0

. 002605 0. 002 758 0.002615 0

. 002624 Pe rc ent of Rf d
13. 7% 15

. 7% 13 .4 % 13.6% 13.9% 13.0% 30 .5 % 11

. 6% 46.2% 17. 2% 10.0%

9. 3 % 10

. 2 %

9

. 7% 9

. 7% 25

. 1%

9

. 7% 59.9% 41.0% 19 .4 %

9

. 6% 10.2%

9. 7% 9.7%Acequin ocy l Di etar y Expo s ure and Ri s k Ass e ss m e nt 0 4 3 13 06 

### Attac hment 3: D EE M-FCID Ch ronic Ex po s ure a nd Ri s k Estim ates - Food Onl y

us EPA Ver

. 3.16, 03-08-d DEEM-FCID Chronic analysis for ACEQUINOCYL NHANES 2003

- 2008 2

- day Residue file name: C: \ Users \ gkramer \ OneDrive

- Environmental Protection Agency (EPA)\Gk\$$Acequinocyl\006329C_Food Only.ROS Adjustment factor H2 used. Analysis Date 01-27-2016/14:02:52 Residue file dated : 01-27-2016/14:02:19 Reference dose (RfD, Chronic) = .027 mg / kg bw / day COMMENT l: No acute dietary endpoint; not carcinogen. cRfD=cPAD
Total exposure by population subgroup

Population

Subgroup
Total US Population Hispanic Non-Hisp-White Non-Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infants Female 13+ PREG Ch i l dren 1

- 6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants F

emale 13-50 Children 1

- 2 Children 3

- 5 Children 6-12 Youth 13-19 Adults 20-49 Adults 50-99 Female 13-49 Total Exposure
mg / kg body wt/day
0.003571 0. 004115 0.003466 0.003562 0.003581 0.003389 0.007756 0.003013 0.012282 0.004530 0.002592 0.002412 0.002624 0.002484 0.002485 0.006408 0.002490 0.015966 0.010913 0.005104 0.002503 0.002619 0. 002477 0.002485

Page 1 2of 1 2 Percent of Rfd
13.2% 15.2% 12.8% 13.2% 13. 3% 12.6% 28. 7% 11. 2% 45

. 5% 16.8%

9 .6\ 8.9% 9

. 7% 9.2% 9.2% 23. 7%

9.2% 59 .1% 40 .4% 18.9%

9 .3% 9.7% 9.2% 9.2%