62276 Federal Register / Vol. 69, No. 205 / Monday, October 25, 2004 / Notices 

Dated: October 18, 2004. 

Alvin Hall, 

Director, Management Analysis and Services 

Office, Centers for Disease Control and 

Prevention.

[FR Doc. 04–23813 Filed 10–22–04; 8:45 am] 

BILLING CODE 4163–18–P

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

Iowa Ordnance Plant

AGENCY: Centers for Disease Control and 

Prevention (CDC), Department of Health 

and Human Services (HHS).

ACTION: Notice.

SUMMARY: The Department of Health and 

Human Services gives notice of a 

decision to evaluate a petition to 

designate a class of employees at the 

Iowa Ordnance Plant, also known as the 

Iowa Army Ammunition Plant, in 

Burlington, Iowa to be included in the 

Special Exposure Cohort under the 

Energy Employees Occupational Illness 

Compensation Program Act of 2000. The 

initial proposed definition for the class 

being evaluated, subject to revision as 

warranted by the evaluation, is as 

follows: 

Facility: Iowa Ordnance Plant, 

Burlington, Iowa. 

Locations: Line 1 (which includes 

Yard C, Yard G, Yard L, Firing Site 

Area, Burning Field ‘‘B’’, and Storage 

Sites for Pits and Weapons including 

Buildings 73 and 77). 

Job Titles and/or Job Duties: All 

Technicians (Laboratory, Health 

Physics, Chemical, X-ray, etc.), 

Production Personnel (hourly and 

salaried), Engineers, Inspectors, Safety 

Personnel, Physical Security Personnel, 

and Maintenance Persons. Period of 

Employment: 1947–1974.

FOR FURTHER INFORMATION CONTACT:

Larry Elliott, Director, Office of 

Compensation Analysis and Support, 

National Institute for Occupational 

Safety and Health, 4676 Columbia 

Parkway, MS C–46, Cincinnati, OH 

45226, telephone 513–533–6800 (this is 

not a toll-free number). Information 

requests can also be submitted by e-mail 

to OCAS@CDC.GOV.

Dated: October 18, 2004. 

James D. Seligman, 

Associate Director for Program Services, 

Centers for Disease Control and Prevention.

[FR Doc. 04–23814 Filed 10–22–04; 8:45 am] 

BILLING CODE 4163–19–M

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Public Health Service 

National Toxicology Program; Call for 

Additional Public Comments on 21 

Substances, Mixtures and Exposure 

Circumstances Proposed for Review 

for Listing or Changing the Current 

Listing in the Report on Carcinogens, 

Twelfth Edition 

Background 

The National Toxicology Program 

(NTP) initially announced its intent to 

review additional agents, substances, 

mixtures and exposure circumstances 

for possible listing or changing the 

current listing in the Report on 

Carcinogens (RoC), Twelfth Edition in a 

May 19, 2004 Federal Register notice 

(69 FR 28940 (May 19, 2004)). Based on 

some of the comments received in 

response to this notice, the NTP is 

concerned that there might have been 

confusion about the procedures that will 

be used for review of nominations to the 

12th RoC. A detailed description of the 

current review procedures, including 

the steps in the formal review process, 

is available on the Web at http://ntpserver.niehs.nih.gov (select on Report on 

Carcinogens) or can be obtained by 

contacting: Dr. C.W. Jameson, National 

Toxicology Program, Report on 

Carcinogens, 79 Alexander Drive, 

Building 4401, Room 3118, PO Box 

12233, Research Triangle Park, NC 

27709; phone: (919) 541–4096, fax: (919) 

541–0144, e-mail: 

jameson@niehs.nih.gov.

Public Comment Requested 

Because of the possibility of 

confusion over the review procedures 

for the 12th RoC nominations, 

additional comments concerning the 

nominations for listing or changing the 

current listing in the 12th RoC will be 

accepted by the NTP for a period of 30 

days from the publication date of this 

announcement in the Federal Register. 

The following table identifies the 21 

nominations the NTP may consider for 

review in 2004 or 2005, as either a new 

listing in or changing the current listing 

in the 12th RoC. These nominations are 

provided with their Chemical Abstracts 

Services (CAS) Registry numbers (where 

available) and pending review action. 

Additional nominations for the 12th 

RoC or modifications to the nominations 

in the attached table may be identified 

and would be announced in future 

Federal Register notices. The NTP 

solicits public input on these 21 

nominations and asks for relevant 

information concerning their 

carcinogenesis, as well as current 

production data, use patterns, or human 

exposure information. The NTP also 

invites interested parties to identify any 

scientific issues related to the listing of 

a specific nomination in the RoC that 

they feel should be addressed during the 

reviews. 

Individuals who submitted comments 

in response to the May 19, 2004 Federal 

Register (69 FR 28940 (May 19, 2004)) 

that initially announced the 12th RoC 

nominations need not re-submit their 

comments as they are already part of the 

public record. Individuals submitting 

new or additional public comments are 

asked to include relevant contact 

information (name, affiliation (if any), 

address, telephone, fax, and e-mail). 

Comments or questions should be 

directed to Dr. C.W. Jameson at the 

address listed above. 

Additional Nominations Encouraged 

The NTP solicits and encourages the 

broadest participation from interested 

individuals or parties in nominating 

agents, substances, or mixtures for 

review for the Twelfth and future RoCs. 

Nominations should contain a rationale 

for review. Appropriate background 

information and relevant data (e.g., 

journal articles, NTP Technical Reports, 

IARC listings, exposure surveys, release 

inventories, etc.), which support the 

review of a nomination, should be 

provided or referenced when possible. 

Contact information for the nominator 

should also be included (name, 

affiliation (if any), address, telephone, 

fax, and email). Nominations should be 

sent to Dr. Jameson’s attention at the 

address given above.

Dated: October 15, 2004. 

Samuel Wilson, 

Deputy Director, National Institute of 

Environmental Health Sciences.

Federal Register / Vol. 69, No. 205 / Monday, October 25, 2004 / Notices 62277

SUMMARY FOR AGENTS, SUBSTANCES, MIXTURES OR EXPOSURE CIRCUMSTANCES TO BE REVIEWED IN 2004–2005 FOR

POSSIBLE LISTING THE REPORT ON CARCINOGENS, TWELFTH EDITION

Nomination to be reviewed/CAS number Primary uses or exposures Nominated by Basis for nomination 

Aristolochia-Related 

Herbal Remedies.

Several Aristolochia species (notably A. 

contorta, A. debilis, A. fangchi and A. 

manshuriensis) have been used in traditional Chinese medicine as anti-rheumatics, 

as diruretics, in the treatment of edema 

and for other conditions such as hemorrhoids, coughs and asthma.

NIEHS1 ...................... Herbal remedies containing the plant genus 

Aristolochia: IARC 2 finding evidence of 

carcinogenicity in humans (Vol. 83, 2002). 

Aristolochic Acid .......... Aristolochic acid, the principle extract from 

Aristolochia, is a mixture of 

nitrophenanthrene carboxylic acids.

NIEHS1 ...................... Naturally occurring mixtures of aristolochic 

acids: IARC 2 finding of sufficient evidence 

of carcinogenicity in animals and limited 

evidence in humans (Vol. 83, 2002). 

Asphalt fumes .............. Asphalt is a petroleum product used in paving and roofing operations. Asphalt fumes 

are a cloud of small particles generated 

from the gaseous state after volatilization 

of asphalt aggregates.

John Schelp of 

NAACP–Durham 

Chapter.

Human epidemiological studies have reported 

an increased risk in lung cancer among 

workers exposed to asphalt fumes and asphalt fumes caused skin tumors in experimental animals. Additionally, known human 

carcinogens (PAHs) have been found in 

asphalt fumes. 

Atrazine (192–24–9) .... Atrazine is an herbicide used to control grass 

and broad-leaved weeks. Atrazine has 

been detected at levels that exceeded or 

approached the MCL for atrazine in 200 

community surface drinking water systems.

NIEHS1 ...................... IARC 2 finding of sufficient evidence of carcinogenicity in animals (Vol. 73, 1999). 

Benzofuran (271–89–6) Benzofuran is produced by isolation from 

coal-tar oils. Benzofuran is used in the 

manufacture of coumarone-indene resins, 

which harden when heated and are used to 

make floor titles and other products.

NIEHS1 ...................... Results of a NTP bioassay (TR 370, 1989), 

which reported clear evidence of 

carinogenicity in male and female mice and 

some evidence of carcinogenicity in female 

rats. 

Captafol (2425–06–01) Captafol is a fungicide that has been widely 

used since 1961 for the control of fungal 

diseases in fruits, vegetables and some 

other plants. Use of captafol in the United 

States was banned in 1999.

NIEHS1 ...................... IARC 2 finding of sufficient evidence of carcinogenicity in animals (Vol. 53, 1991). 

IARC also noted that captafol is positive in 

many genetic assays, including the in-vivo 

assay for dominant lethal mutation. 

Cobalt/Tungsten-Carbide Hard Metal 

Manufacturing.

Hard-metals are manufactured by a process 

of powder metallurgy from tungsten and 

carbon (tungsten carbide), and small 

amounts of other metallic compounds using 

cobalt as a binder. Hard metals are used to 

make cutting and grinding tools, dies, and 

wear products for a broad spectrum of industries including oil and gas drilling, and 

mining.

NIEHS1 ...................... Recent human cancer studies on the hard 

metal manufacturing industry showing an 

association between exposure to hard metals (cobalt tungsten-carbide) and lung cancer. 

Di (2-Ethylhexyl) 

phthalate (DEHP) 

(117–81–7).

DEHP is mainly used as a plasticizer in polyvinyl chloride (PVC) resins for fabricating 

flexible vinyl products. PVC resins have 

been used to manufacture toys, dolls, vinyl 

upholstery, tablecloths and many other 

products.

Jun Ki-Chul, President 

of Aekyung Petrochemical Co., LTD 

of Seoul, Korea (for 

delisting).

Currently listed in the RoC as reasonably anticipated to be a human carcinogen. 

IARC reclassification as not classifiable as to 

its carcinogenicity to humans (Group 3) 

(Vol. 73, 2000). IARC stated that there was 

sufficient evidence for the carcinogenicity in 

experimental animals; however, the mechanism for liver tumor involves peroxisome 

proliferation that is not relevant to humans. 

Etoposide in combination with cisplatin and 

bleomycin.

Etoposide in combination with cisplating and 

bleomycin is used to treat testicular germ 

cell cancers.

NIEHS1 ...................... IARC 2 finding of sufficient evidence of carcinogenicity in humans (Vol. 76, 2000). 

Etoposide (33419–42–

0).

Etoposide is a DNA topoisomerase II inhibitor 

used in chemotherapy for non-Hodgkin’s 

lyumphoma, small-cell lung cancer, testicular cancer, lymphomas and a variety of 

childhood malignancies.

NIEHS1 ...................... IARC 2 finding of limited evidence of carcinogenicity in humans (Vol. 76, 2000). 

62278 Federal Register / Vol. 69, No. 205 / Monday, October 25, 2004 / Notices 

SUMMARY FOR AGENTS, SUBSTANCES, MIXTURES OR EXPOSURE CIRCUMSTANCES TO BE REVIEWED IN 2004–2005 FOR

POSSIBLE LISTING THE REPORT ON CARCINOGENS, TWELFTH EDITION—Continued

Nomination to be reviewed/CAS number Primary uses or exposures Nominated by Basis for nomination 

Glass wool (respirable 

size): Two nominations: 

(1) Insulation glass 

wool fibers. 

(2) Special purposes 

glass fibers. 

The major uses of glass wool are in thermal, 

electrical, and acoustical insulation, weatherproofing, and filtration media. In 1980, 

approximately 80% of the glass wool produced for structural insulation was used in 

houses. Special purpose fibers are used 

for high-efficiency air filtration media, and 

acid battery separators.

North American Insulation Manufacturers 

Association nominated glass wool 

(respirable size) for 

delisting.

Special purpose glass 

wool fibers: NIEHS1.

Glass wool (respirable size) is currently listed 

in the RoC as reasonably anticipated to be 

a human carcinogen. 

Insulation glass wool: IARC 2 finding of limited evidence of carcinogenicity in animals 

and evaluation as not classifiable as to its 

carcinogenicity to humans (Group 3) (Vol. 

81, 2002). 

Special-purpose glass fibers: IARC 2 finding 

of sufficient evidence of carcinogenicity in 

animals (Vol. 81, 2002). 

Metalworking Fluids ..... Metal working fluids are complex mixtures 

that may contain mixtures of oil, emulsifiers, anti-weld agents, corrosion inhibitors, 

extreme pressure additives, buffers 

biocides and other additives. They are 

used to cool and lubricate tools and working surfaces in a variety of industrial machining and grinding operations.

NIEHS1 ...................... Recent human cancer studies of metal working fluid that show an association between 

exposure to these materials and cancer at 

several tissue sites. 

otho-Nitrotolume (88–

72–2).

ortho-Nitrotoluene is used to synthesize agricultural and rubber chemicals, azo and sulfur dyes, and dyes for cotton, wool, silk, 

leather, and paper.

NIEHS1 ...................... Results of a NTP bioassay (TR 504, 2002), 

which reported clear evidence of carcinogenicity in rats and mice. 

Oxazepam (604–75–1) Oxazepam is a benzodiazepine used extensively since the 1960s for the treatment of 

anxiety and insomnia and in the control of 

symptoms of alcohol withdrawal.

NIEHS1 ...................... Results of a NTP bioassay (TR 443, 1993), 

which reported clear evidence of carcinogenicity in male and female mice. 

Riddelliine (23246–96–

0).

Riddelliine is found in class of plants growing 

in western US. Cattle, horses and sheep 

ingest these toxic plants. Residues have 

been found in milk and honey.

NIEHS1 ...................... Results of a NTP bioassay (TR 508, 2003), 

which reported clear evidence of carcinogenicity in male and female rats and mice. 

Styrene (100–42–5) ..... Styrene is used in the production of polystyrene, acrylonitrile-butadiene-styreen resins, styrene-butadiene rubbers and latexes, 

and unsaturated polystyrene resins.

Lorenzo Tomatis ........ IARC 2 finding of limited evidence of carcinogenicity in animals and limited evidence of 

carcinogenicity in humans (Vol. 82, 2002). 

Talc—Two nominations 

(1) Cosmetic talc 

Occupational exposure 

to talc 

Talc occurs in various geological settings 

around the world. Exposure to general population occurs through use of products 

such as cosmetics. Occupational exposure 

occurs during mining, milling and processing.

NIEHS1 ...................... The NTP deferred consideration of listing talc 

(asbestiform and non-asbestiform talc) in 

the 20th RoC because its 2000 review of 

talc found confusion in the scientific literature over the mineral nature of talc. 

Given the confusion over defining exposure 

to talc based on asbestiform fibers, the 

NTP has decided that the most appropriate 

approach would be to characterize talc exposure as cosmetic talc and occupational 

exposure to talc. The basis for the review 

of talc is as follows: 

Cosmetic talc: Human epidemiological studies reporting an increased risk of ovarian 

cancer among women using talc for personal use. 

Occupational exposure to talc: Human epidemiological studies reporting an increase 

risk of cancer among workers exposed to 

talc. 

Teniposide (29767–20–

2).

Teniposide is a DNA topoisomerase II inhibitors used mainly in the treatment of adult 

and childhood leukemia.

NIEHS1 ...................... IARC 2 finding of limited evidence of carcinogenicity in humans (Vol. 76, 2000). 

Federal Register / Vol. 69, No. 205 / Monday, October 25, 2004 / Notices 62279

SUMMARY FOR AGENTS, SUBSTANCES, MIXTURES OR EXPOSURE CIRCUMSTANCES TO BE REVIEWED IN 2004–2005 FOR

POSSIBLE LISTING THE REPORT ON CARCINOGENS, TWELFTH EDITION—Continued

Nomination to be reviewed/CAS number Primary uses or exposures Nominated by Basis for nomination 

Vinyl Mono-Halides as 

a class.

Vinyl halides are used in the production of 

polymers and copolymers. Vinyl bromide is 

mainly used in polymers as a flame retardant and in the production of monoacrylic fibers for carpet-backing materials. Vinyl 

Chloride is used to produced polyvinyl 

chloride and copolymers. Vinyl Fluoride is 

used in the production of polyvinyl fluoride, 

which when laminated with aluminum, steel 

and other materials is used as a protective 

surface for the exteriors of residential and 

commercial buildings.

NIEHS1 ...................... Vinyl Fluoride and Vinyl Bromide are currently listed in the RoC as reasonably anticipated to be a human carcinogen and 

Vinyl Chloride is currently listed in the RoC 

as known to be a human carcinogen in the 

Reports on Carcinogens. 

Vinyl Mono-Halides: Structural similarities and 

common mechanisms of tumor formation. 

1The National Institute of Environmental Health Sciences (NIEHS). 

2 International Agency for Research on Cancer (IARC). 

[FR Doc. 04–23788 Filed 10–22–04; 8:45 am] 

BILLING CODE 4140–01–P

DEPARTMENT OF HOMELAND 

SECURITY 

Bureau of Customs and Border 

Protection 

Notice of Cancellation of Customs 

Broker License

AGENCY: Bureau of Customs and Border 

Protection, U.S. Department of 

Homeland Security.

ACTION: General notice.

SUMMARY: Pursuant to section 641 of the 

Tariff Act of 1930, as amended, (19 

U.S.C. 1641) and the Customs 

Regulations (19 CFR 111.51), the 

following Customs broker licenses are 

canceled with prejudice.

Name License

No. 

Issuing

port 

International Customs Brokers.13684 Houston. 

Diana M. Cachia ..... 05635 New York. 

Dated: October 8, 2004. 

Jayson P. Ahern, 

Assistant Commissioner, Office of Field 

Operations.

[FR Doc. 04–23806 Filed 10–22–04; 8:45 am] 

BILLING CODE 4820–02–P

DEPARTMENT OF HOMELAND 

SECURITY 

Bureau of Customs and Border 

Protection 

Notice of Cancellation of Customs 

Broker License

AGENCY: Bureau of Customs and Border 

Protection, U.S. Department of 

Homeland Security.

ACTION: General notice.

SUMMARY: Pursuant to section 641 of the 

Tariff Act of 1930, as amended, (19 

U.S.C. 1641) and the Customs 

Regulations (19 CFR 111.51), the 

following Customs broker license is 

canceled without prejudice.

Name License 

No. 

Issuing 

port 

J.E. Lowden & Co. ... 05118 San Francisco. 

Dated: October 8, 2004. 

Jayson P. Ahern, 

Assistant Commissioner, Office of Field 

Operations.

[FR Doc. 04–23807 Filed 10–22–04; 8:45 am] 

BILLING CODE 4820–02–P

DEPARTMENT OF HOMELAND 

SECURITY 

Bureau of Customs and Border 

Protection 

Cancellation of Customs Broker 

License Due to Death of the License 

Holder

AGENCY: Bureau of Customs and Border 

Protection, Department of Homeland 

Security.

ACTION: General notice.

SUMMARY: Notice is hereby given that, 

pursuant to Title 19 of the Code of 

Federal Regulations § 111.51(a), the 

following individual Customs broker 

license and any and all permits have 

been cancelled due to the death of the 

broker:

Name License 

No. Port name 

Richard J. Oates ....... 05109 Mobile 

Dated: October 8, 2004. 

Jayson P. Ahern, 

Assistant Commissioner, Office of Field 

Operations.

[FR Doc. 04–23808 Filed 10–22–04; 8:45 am] 

BILLING CODE 4820–02–P

DEPARTMENT OF HOMELAND 

SECURITY 

Bureau of Customs and Border 

Protection 

Notice of Cancellation of Customs 

Broker National Permit

AGENCY: Bureau of Customs and Border 

Protection, U.S. Department of 

Homeland Security.

ACTION: General Notice.

SUMMARY: Pursuant to section 641 of the 

Tariff Act of 1930, as amended, (19 

U.S.C. 1641) and the Customs 

Regulations (19 CFR 111.51), the 

following Customs broker national 

permits are canceled without prejudice.

Name Permit

No. 

Issuing

port 

J.E. Lowden & 

Co.

99–00190 Headquarters. 

Word Asia Logistics, Inc.99–00281 Headquarters.