Exhibit 10.1


 


 


Certain information marked as [****] has been excluded from this exhibit because it is both (i) not material
and (ii) would be competitively harmful if publicly disclosed.


200 PINE STREET OFFICE LEASE


 


This Lease is made and entered
into as of March 25, 2021, by and between M & E, LLC, a California Limited Liability Company (“Landlord”), and
Jaguar Health, Inc. a Delaware corporation (“Tenant”), who agree as follows:


 


		1.	DEFINITIONS.



 


As used in this
Lease, the following terms shall have the following meanings specified below:


 


		1.1	Base Rent:



 


	Months	Monthly Base Rent




 


	1-12:	$42,104.00



 


	13-24	$43,367.12



 


	25-36	$44,668.13



 


		1.2	Base
Year: [****]



 


		1.3	Building: The building
and other improvements on the real property located at 200 Pine Street, San Francisco, California.



 


		1.4	Building Operating Costs:
Has the meaning set forth in Section 5.2.



 


		1.5	Commencement Date: September 1,
2021



 


		1.6	Common Areas: The Building
common corridors and hallways, restrooms, stairways, patios, elevators and other generally understood public or common areas. Landlord
shall have the right to regulate or restrict the use of the Common Areas.



 


		1.7	Comparison Year     Has
the meaning set forth in Section 5.3(a).



 


		1.8	Expiration Date: Thirty-Six
(36) months following the Commencement Date, scheduled for August 31, 2024



 


		1.9	First
Adjustment Date: [****]



 


		1.10	Guarantor: None.



 


		1.11	Index: Intentionally
deleted.



 


		1.12	Interest Rate: A per
annum rate of interest equal to ten percent (10%) or, if a higher rate is legally permissible, at the highest rate legally permitted.



 






     


     


    

 


		1.13	Landlord's Notice Address:
c/o Colliers International, 101 2nd Street, 11th Floor, San Francisco, California 94105, Attn: Property Management,
or by email to: [To be designated], or such other address as Landlord shall designate from time to time.



 


		1.14	Premises: That portion
of the Building containing approximately 10,526 square feet of Rentable Area, shown on Exhibit "A," located on the fourth
(4th) and sixth (6th) floors of the Building and known as Suite 400 and Suite 600



 


		1.15	Real Estate Brokers:
Ben Osgood and Dylan Peters, Recreate - Tenant’s Broker; James Sobel, Brendon Kane, Colliers International - Landlord’s Broker.



 


		1.16	Real Property Taxes:
Has the meaning set forth in Section 6.2.



 


		1.17	Rentable Area: As to
both the Premises and the Building, the respective measurements of floor area as may from time to time be subject to lease by Tenant
and all tenants of the Building, respectively, as determined by Landlord and applied on a consistent basis throughout the Building.



 


		1.18	Scheduled Commencement Date:
September 1, 2021



 


		1.19	Security Deposit: $44,668.13



 


		1.20	Tenant’s Notice Address:
200 Pine Street, Suite 400 San Francisco, CA 94104, Attn: Jonathan Wolin, or by email to jwolin@jaguar.health.



 


		1.21	Tenant's Proportionate Share:
25.74%. Such share is a fraction, the numerator of which is the Rentable Area of the Premises, and the denominator of which is the Rentable
Area of the Building, as determined by Landlord from time to time. The Building contains a total Rentable Area of approximately 40,882
square feet.



 


		1.22	Tenant's Use: General
office use.



 


		1.23	Term: Has the meaning
set forth in Section 3.1.



 


		2.	LEASE OF PREMISES.



 


Landlord hereby leases to Tenant, and
Tenant hereby leases from Landlord, the Premises for the Term and subject to the terms and provisions contained in this Lease. The Premises
are located within the Building. Tenant shall have the non-exclusive right (unless otherwise provided herein) to the use of the Common
Areas in common with Landlord, other tenants and occupants of the Building and other parties entitled to use the Common Areas, subject
to the provisions of this Lease and to the Building rules and regulations.


 


		3.	TERM.



 


3.1           Delivery
of Possession. This Lease shall become effective upon execution by Landlord and Tenant. The term of this Lease shall commence on the
Commencement Date (with Landlord’s Work outlined in Exhibit C completed) and shall continue until the Expiration Date (the
 “Term”), unless earlier terminated in accordance with this Lease or unless extended as hereinafter provided. If for any reason
Landlord cannot deliver possession of the Premises to Tenant on the Scheduled Commencement Date, Landlord shall not be subject to any
liability for such failure, and the Commencement Date shall be adjusted accordingly.


 






     


     


    

 


3.2         [****]


 


3.3         Option
to Renew. Subject to the terms and conditions hereinafter set forth, Landlord hereby grants Tenant one (1) option to extend the
term of this Lease (the “Option to Extend”) for one (1) three (3) year period, commencing immediately after the
expiration of the initial term (the “Extension Term”). Tenant’s election to exercise the above Option to Extend must
be given to Landlord in writing not less than two hundred seventy (270) days or more than three hundred sixty-five (365) days prior to
expiration of the last lease year of the original Term.


 


Tenant’s Option
to Extend shall be upon the terms and conditions contained herein except as set forth below and except that there shall be no further
option to extend the term beyond the Extension Term. If Tenant exercises the Option to Extend, the Base Expenses Year and Base Tax Year
shall be changed from the date on the Lease Summary to the year following the first year of the option period. The Option to Extend described
in this Section 3.3 shall be deemed personal to Tenant and may not be exercised or assigned, voluntarily or involuntarily, by or
to any person or entity other than Tenant, including any permitted assignee or subtenant. Tenant shall continue possession of the Premises
in its as is condition and Landlord shall have no obligation to do any work or otherwise to prepare the Premises for the Renewal Term.
If Tenant exercises the Option to Extend, the Base Rent for the Premises during the Extension Term shall be one hundred percent (100%)
of the fair market rent for the Premises determined in the manner set forth below; however, in no event will the Base Rent be less than
the Base Rent as of the last month of the original lease term. As used herein, Fair Market Rent for the Premises shall mean the Basic
Rental and all other monetary payments and escalations, that Landlord could obtain from a third party desiring to lease the Premises,
taking into account the size, location and floor level of the Premises, the quality of construction of the Building, the services provided
under the terms of this Lease, the rental then being obtained for leases of space comparable to the Premises in the Building, and within
the downtown San Francisco Financial District and all other factors that would be relevant to a willing third party desiring to lease
the Premises and a willing Landlord desiring to let the Premises for the subject period of the lease term in determining the rental such
party would be willing to pay or receive therefore provided that no allowance for the construction of Tenant improvements shall be taken
into account in determining Fair market Rent.


 


Notwithstanding
anything to the contrary contained herein, all option rights of Tenant pursuant to this Section 3.3 shall automatically terminate
without notice and be of no further force and effect whether or not Tenant has timely exercised the Option to Extend granted herein if
an Event of Default exists at the time of exercise of the option or at the time of commencement of the Extension Term.


 






     


     


    

 


		4.	RENT.



 


4.1.          Payment
of Base Rent. Tenant shall pay to Landlord throughout the Term the Base Rent for the Premises. The Base Rent shall be payable in advance
beginning on the Commencement Date and on the first day of each calendar month of the Term thereafter. If the Term begins (or ends) on
a day other than the first (or last) day of a calendar month, the Base Rent for the partial month shall be prorated on a per diem basis
on the basis of a thirty (30) day month. Tenant shall pay Landlord the first (1st) month's Base Rent when Tenant executes the
Lease. This is a payment in addition to the Security Deposit and will be applied to the Base Rent beginning month 1.


 


4.2           Adjusted
Base Rent. Intentionally deleted.


 


4.3           Definition
of Rent. All costs and expenses which Tenant assumes or agrees to pay to Landlord under this Lease shall be deemed additional rent
(which, together with the Base Rent, is sometimes referred to herein as the “Rent”). The Rent shall be paid to Landlord, the
Building manager or such other person, and at such place, as Landlord may from time to time designate in writing, without any prior notice
or demand therefore and without deduction, offset or counterclaim, in lawful money of the United States of America.


 


		5.	BUILDING OPERATING COSTS.



 


		5.1	Tenant’s Obligation. During each calendar year during the Term, Tenant shall pay to Landlord,
as additional rent and in addition to the Base Rent and all other payments due under this Lease, an amount equal to Tenant's Proportionate
Share of increases in Building Operating Costs in the manner provided below.



 


		5.2	Definition. The term “Building Operating Costs” means all costs and expenses paid or
incurred by Landlord in the ownership, management, operation, repair, replacement and maintenance of the Building, including, without
limitation, the following:



 


		(a)	Costs of electricity, water, gas, steam and other utilities and services furnished to or consumed within
the Building, and all utility taxes thereon;



 


		(b)	Costs of all supplies and materials used by Landlord in connection with the Building;



 


		(c)	Premiums and other charges for insurance, including, without limitation, all risk, commercial general
liability, property damage, worker’s compensation, employer’s liability, earthquake, flood and such other insurance in such
forms of coverage and in such amounts as Landlord, in its sole discretion, shall elect to maintain with respect to the Building or shall
be obligated to maintain with respect to the Building by any mortgagee or lender;



 


		(d)	Costs of, and all amounts payable under, service, maintenance and inspection contracts for janitorial,
window-cleaning, garbage removal, extermination, elevator, escalator, plumbing, electrical and mechanical equipment, heating, ventilating
and air-conditioning (“HVAC”) equipment, security protection, landscape maintenance and costs of purchasing or renting equipment,
supplies, tools, materials and uniforms;



 






     


     


    

 


		(e)	Compensation (including employment taxes and fringe benefits) of all persons who perform duties connected
with the operation, maintenance or repair of the Building, and equipment, improvements and facilities located within the Building, including,
without limitation, engineers, janitors, painters, floor waxers, window washers and security personnel (but excluding persons performing
services not uniformly available to or performed for substantially all Building tenants);



 


		(f)	Fees and costs of management of the Building, whether managed by Landlord, an affiliate of Landlord or
an independent contractor (including, without limitation, an amount equal to the fair market value of any on-site manager's office);



 


		(g)	Rental expenses for (or a depreciation allowance on) personal property used in the maintenance, operation
or repair of the Building;



 


		(h)	License, permit and inspection fees; costs of complying with applicable statutes, ordinances, rules and
regulations of governmental authorities, including, without limitation, repairs, maintenance, alterations, additions or improvements required
in connection therewith; attorneys’, accountants’ and consultants’ fees;



 


		(i)	The costs of any capital improvements made to the Building by Landlord in order to reduce Building Operating
Costs; made to the Building by Landlord after the date of this Lease that are required under any governmental law or regulation that was
not applicable to the Building at the time it was constructed; or made by Landlord in order to repair, replace or improve the Building
or portions or components thereof. The costs shall be amortized over such period, as shall reasonably be determined by Landlord, and the
amortization expense shall include interest on the unamortized balance of the cost of such capital improvement at the rate of ten percent
(10%) per annum or such higher rate as may have been paid by Landlord on funds borrowed for the purpose of constructing or installing
such capital improvements; and



 


		(j)	Other costs and expenses which are of a type generally reimbursed by Tenants of comparable office buildings
in San Francisco, California.



 






     


     


    

 


Building Operating Costs shall not include
Real Property Taxes which shall be governed by Article 6 below.


 


		5.3	Payment. Tenant's Proportionate Share of increases in Building Operating Costs shall be payable
by Tenant to Landlord as follows:



 


		(a)	Beginning with the calendar year following the Base Year and for each calendar year thereafter (each,
a “Comparison Year”), Tenant shall pay to Landlord an amount equal to Tenant's Proportionate Share of the amount by which
the Building Operating Costs paid or incurred by Landlord in the Comparison Year exceeds the Building Operating Costs paid or incurred
by Landlord for the Base Year. This excess is referred to as the “Excess Operating Costs.” The Building Operating Costs for
each Comparison Year in which less than ninety-five percent (95%) of the Rentable Area of the Building has been occupied for the entire
Computation Year shall be determined by adjusting the actual Building Operating Costs to equal Landlord’s reasonable estimate of
what the Building Operating Costs would have been if ninety-five percent (95%) of the Rentable Area of the Building had been fully occupied
for such entire Comparison Year.



 


		(b)	To provide for current payments of Excess Operating Costs, Tenant shall, at Landlord’s request,
pay as additional rent during each Comparison Year an amount equal to Tenant's Proportionate Share of the Excess Operating Costs payable
during such Comparison Year, as estimated by Landlord from time to time. During December of the Base Year and December of each
subsequent calendar year, or as soon thereafter as practical, Landlord shall notify Tenant of the amount which Landlord reasonably estimates
to be the monthly installments of Tenant’s Proportionate Share of Excess Operating Costs for any Comparison Year. Tenant shall make
such monthly installments commencing on the first day of each month during the ensuing calendar year. If such notice is not given in December Tenant
shall continue to pay on the basis of the prior year’s estimate until the month after such notice is given.



 


		(c)	On or before April 1 of each Comparison Year after the first Comparison Year (or as soon thereafter
as is practicable), Landlord shall deliver to Tenant a statement setting forth the actual amount of Tenant's Proportionate Share of Excess
Operating Costs for the preceding Comparison Year. If the actual amount of Tenant's Proportionate Share of Excess Operating Costs for
the preceding Comparison Year exceeds the total of the estimated monthly payments made by Tenant for such year, Tenant shall pay Landlord
the amount of the deficiency within ten (10) days of the receipt of the statement. If the total of the estimated monthly payments
made by Tenant for such year exceeds the actual amount of Tenant's Proportionate Share of Excess Operating Expenses for such Comparison
Year, then Landlord shall credit against Tenant's next ensuing monthly installments of Tenant’s Proportionate Share of Excess Operating
Costs an amount equal to the difference until the credit is exhausted. If a credit is due from Landlord on the Expiration Date, Landlord
shall pay Tenant the amount of the credit. In no event shall Landlord’s failure to provide Tenant with a timely statement of the
amount due relieve Tenant of Tenant’s responsibility to reimburse Landlord for Operating Costs. The obligations of Tenant and Landlord
to make payments required under this Section 5 shall survive the Expiration Date.



 


		(d)	Tenant's Proportionate Share of Excess Operating Costs in any Comparison Year having less than 365 days
shall be appropriately prorated.



 






     


     


    

 


		6.	REAL PROPERTY TAXES.



 


		6.1	Tenant’s Obligation. During each calendar year during the Term, Tenant shall pay to Landlord,
as additional rent and in addition to the Base Rent and all other payments due under this Lease, an amount equal to Tenant’s Proportionate
Share of increases in Real Property Taxes in the manner provided below.



 


		6.2	Definition. The term “Real Property Taxes” means all taxes, assessments, water and
sewer charges and other similar governmental charges (including costs and expenses of contesting the amount or validity thereof by appropriate
administrative or legal proceedings) levied on or attributable to the Building or its operation, including, without limitation, all real
property taxes and general and special assessments; charges, fees, levies and assessments for transit, housing, police, fire or other
governmental services or purported benefits to the Building; service payments in lieu of taxes; environmental surcharges; excise taxes;
sales and/or use taxes; employee taxes; water and sewer taxes and charges; any tax, fee or excise on the act of entering into this Lease,
on the use or occupancy of the Building or any part thereof, or upon or measured by the rent payable under any lease or in connection
with the business of renting space in the Building; and all other governmental impositions of any kind or nature whatsoever, regardless
of whether or not customary or within the contemplation of the parties hereto and regardless of whether resulting from increased rate
and/or valuation, or whether extraordinary or ordinary, general or special, foreseen or unforeseen, or similar or dissimilar to any of
the foregoing, which may now or hereafter be levied or assessed against Landlord by the United States of America, the State of California,
the City and County of San Francisco or any political subdivision, public corporation, district or other political or public entity, and
any other tax, fee or other excise, however described, levied or assessed as a substitute for, or as an addition to (in whole or in part),
any other such taxes. Notwithstanding the foregoing, “Real Property Taxes” shall not include any net income, franchise, capital
stock, estate or inheritance taxes.



 


		6.3	Payment. Tenant's Proportionate Share of increases in Real Property Taxes shall be payable by Tenant
to Landlord as follows:



 


		(a)	For each, Comparison Year, Tenant shall pay to Landlord an amount equal to Tenant's Proportionate Share
of the amount by which the Real Property Taxes paid or incurred by Landlord in the Comparison Year exceeds the Real Property Taxes paid
or incurred by Landlord for the Base Year (the “Excess Taxes”). Notwithstanding the foregoing, such calculation of Excess
Taxes shall be net of any reimbursements Landlord otherwise receives, regardless of payer, pursuant to section 6.4.



 


		(b)	To provide for current payments of the Excess Taxes, Tenant shall, at Landlord’s request, pay as
additional rent during each Comparison Year an amount equal to Tenant's Proportionate Share of the Excess Taxes payable during such Comparison
Year, as estimated by Landlord from time to time. During December of the Base Year and December of each subsequent calendar
year, or as soon thereafter as practical, Landlord shall notify Tenant of the amount which Landlord reasonably estimates to be the monthly
installments of Tenant’s Proportionate Share of the Excess Taxes for any Comparison Year. Tenant shall make such monthly installments
commencing on the first day of each month during the ensuing calendar year. If such notice is not given in December Tenant shall
continue to pay on the basis of the prior year’s estimate until the month after such notice is given.



 






     


     


    

 


		(c)	On or before April 1 of each Comparison Year (or as soon thereafter as is practicable), Landlord
shall deliver to Tenant a statement setting forth the actual amount of Tenant’s Proportionate Share of the Excess Taxes for the
preceding Comparison Year. In no event shall Landlord’s failure to provide Tenant with a timely statement of the amount due relieve
Tenant of Tenant’s responsibility to reimburse Landlord for Taxes due. If the actual amount of Tenant's Proportionate Share of the
Excess Taxes for the preceding Comparison Year exceeds the total of the estimated monthly payments made by Tenant for such year, Tenant
shall pay Landlord the amount of the deficiency with ten (10) days of the receipt of the statement. If the total of the estimated
monthly payments made by Tenant for such year exceeds the actual amount of Tenant's Proportionate Share of the Excess Taxes for such Comparison
Year, then Landlord shall credit against Tenant's next ensuing monthly installments of Tenant’s Proportionate Share of the Excess
Taxes an amount equal to the difference until the credit is exhausted. If a credit is due from Landlord on the Expiration Date, Landlord
shall pay Tenant the amount of the credit. The obligations of Tenant and Landlord to make payments required under this Section 6
shall survive the Expiration Date.



 


		(d)	Tenant's Proportionate Share of the Excess Taxes in any Comparison year having less than 365 days shall
be appropriately prorated.



 


		6.4	Other Taxes Payable by Tenant. In addition to the Rent and any other amounts to be paid by Tenant
hereunder, Tenant shall reimburse Landlord upon demand, without the benefit of a Base Year, for any and all taxes, levies, assessments,
surcharges, fees and other charges payable by Landlord which are not otherwise reimbursable under this Lease, whether or not now customary
or within the contemplation of the parties, where such taxes, levies, assessments, surcharges, fees and other charges are upon, measured
by or reasonably attributable to (a) the cost or value of Tenant’s equipment, furniture, fixtures and other personal property
located in the Premises, or the cost or value of any leasehold improvements made in or to the Premises by or for Tenant, regardless of
whether title to such improvements is held by Tenant or Landlord; (b) the gross or net Rent payable under this Lease, including,
without limitation, any rental or gross receipts tax levied by any taxing authority with respect to the receipt of the Rent hereunder
such as the San Francisco Business Tax or any similar tax; (c) the possession, leasing, operation, management, maintenance, alteration,
repair, use or occupancy by Tenant of the Premises or any portion thereof; or (d) this transaction or any document to which Tenant
is a party creating or transferring an interest or an estate in the Premises. If it shall be unlawful for Tenant to reimburse Landlord
for any additional taxes as required under this Lease, the Base Rent shall be revised to net Landlord the same net Rent after imposition
of any tax or other charge upon Landlord as would have been payable to Landlord but for the reimbursement being unlawful.



 






     


     


    

 


		7.	LATE CHARGES AND INTEREST.



 


Tenant acknowledges that the late payment
of any Base Rent or other amount which Tenant is obligated to pay under this Lease will cause Landlord to lose the use of that money and
incur costs and expenses not contemplated under this Lease, including, without limitation, administrative and collection costs and processing
and accounting expenses, the exact amount of which are extremely difficult to ascertain. Therefore, if any such installment or other amount
is not received by Landlord when due, Tenant shall pay to Landlord a late charge equal to five percent (5%) of such installment or other
amount. Landlord shall waive such late charge provided Tenant is not more than five (5) days late. Landlord and Tenant agree that
this late charge represents a reasonable estimate of such costs and expenses and is fair compensation to Landlord for the loss suffered
from such late payment by Tenant. In addition, if Tenant fails to pay when due any Rent or other amount which Tenant is obligated to pay
under the terms of this Lease and such failure shall continue for ten (10) days, the unpaid amount shall bear interest at the Interest
Rate from the date on which such payment was due until the date on which Landlord receives such payment. Acceptance of any late charge
and/or interest shall not constitute a waiver of Tenant's default with respect to such late payment by Tenant or prevent Landlord from
exercising any other rights or remedies available to Landlord under this Lease.


 


		8.	SECURITY DEPOSIT.



 


Upon execution of this Lease, Tenant
shall deposit with Landlord as the Security Deposit the amount set forth in Article 1 above as security for Tenant's faithful performance
of its obligations under this Lease. Landlord may commingle the Security Deposit with funds of Landlord, and Landlord shall have no obligation
or liability to pay interest on the Security Deposit. Tenant shall not pledge, assign, transfer or encumber the Security Deposit and any
attempt by Tenant to do so shall be void, without force or effect, and shall not be binding upon Landlord.


 


If Tenant fails to pay any Rent or other
amount when due and payable under this Lease, or fails to perform any of the other terms hereof, Landlord may apply or use all or any
portion of the Security Deposit for Rent payments or any other amount then due and unpaid, for payment of any amount for which Landlord
has become obligated as a result of Tenant's default or breach, and for any loss or damage sustained by Landlord as a result of Tenant's
default or breach, and Landlord may so apply or use the Security Deposit without prejudice to any other remedy Landlord may have by reason
of Tenant's default or breach. If Landlord so applies or uses any of the Security Deposit, Tenant shall, within ten (10) days after
written demand, restore the Security Deposit to the full amount originally deposited. Tenant's failure to do so shall constitute a default
hereunder, and Landlord shall have the right to exercise any remedy provided for in this Lease. If Tenant shall not be in default under
this Lease, Landlord shall return the Security Deposit, or any balance thereof not applied or used in accordance with the provisions of
this Lease, to Tenant within thirty (30) days following the later of the expiration of the Term or the date on which Tenant surrenders
the Premises to Landlord in the condition required under this Lease. If Landlord transfers its interest in the Premises, Landlord may
deliver the Security Deposit to the transferee of Landlord's interest and thereupon be relieved of any further liability or obligation
with respect to the Security Deposit.


 






     


     


    

 


		9.	TENANT'S USE OF THE PREMISES.



 


		9.1	Use. Tenant shall use the Premises solely for the purposes set forth as Tenant's Use in Article 1
above. Tenant, at its sole cost and expense, shall obtain any and all licenses, permits, authorizations and approvals of governmental
authorities required in order to enable Tenant lawfully to conduct its business in the Premises. Nothing contained in this Lease shall
grant to Tenant the exclusive right to conduct within the Building or the Premises the business to be conducted by Tenant in the Premises,
or otherwise limit the right of Landlord to lease space within the Building to such tenants and for such purposes as Landlord, in its
sole discretion, shall deem appropriate. Tenant shall conduct Tenant’s business on the Premises in a lawful manner, reasonably and
in good faith, and shall not do any act tending to injure the reputation of the Building as determined by Landlord. Tenant shall not do
or permit to be done anything which will invalidate or increase the cost of any fire, extended coverage or other insurance policy covering
the Building and/or the property located therein. Tenant shall promptly upon demand reimburse Landlord for any additional premiums charged
for any such insurance policy by reason of Tenant's failure to comply with the provisions of this Article.



 


		9.2	Nuisance or Waste. Tenant shall not do or permit to be done in or about the Premises anything which
will in any way obstruct or interfere with the rights of other tenants or occupants of the Building or injure or annoy them or use or
allow the Premises to be used for any improper, immoral or objectionable purpose, and Tenant not cause, maintain or permit any nuisance
in, on or about the Premises. Tenant shall not commit or suffer the commission of any waste in, on or about the Premises. Tenant shall
not use or operate any equipment, machinery or apparatus within the Premises which will (a) injure, vibrate or shake the Premises
or the Building, (b) overload existing electrical systems or other utilities or equipment servicing the Premises or the Building,
or (c) impair the efficient operation of the sprinkler system (if any) or the HVAC equipment (if any) within or servicing the Premises
or the Building. All noises or odors generated by Tenant’s use of the Premises shall be muffled or contained in such manner that
they do not interfere with the use or occupancy of other tenants or occupants of the Building.



 


		9.3	Compliance with Law. Tenant shall not use or occupy the Premises or permit anything to be done
in, on or about the Premises which will in any way conflict with (a) any statute, ordinance, rule or regulation of governmental
authorities now in force or which may hereafter be enacted or promulgated, (b) any covenant, condition or restriction affecting the
Building or (c) the certificate of occupancy issued for the Premises or any other portion of the Building, and shall, upon notice
from Landlord, immediately discontinue any use of the Premises which is declared by any governmental authority having jurisdiction to
be a violation of law or the certificate of occupancy. Tenant, at Tenant's own cost and expense, shall comply with all statutes, ordinances,
regulations, rules and/or any directions of any governmental authorities having jurisdiction, including, without limitation, the
Americans with Disabilities Act, Title 24 or any other handicap accessibility laws, which shall, by reason of the specific nature of Tenant's
use or occupancy of the Premises (other than general office use), or by reason of any alteration, addition or improvement made by Tenant
in the Premises, impose any duty upon Tenant or Landlord with respect to the Premises or its use or occupancy, or with respect to any
other portion of the Building. Notwithstanding the foregoing, Landlord at its sole cost and expense (except to the extent properly included
in Building Operating Costs) shall be responsible for correcting any such violations respect to the Common Areas. A judgment of any court
of competent jurisdiction or the admission by Tenant in any action or proceeding against Tenant that Tenant has violated any such laws,
ordinances, regulations, rules and/or directions in the use of the Premises shall be deemed to be a conclusive determination of that
fact as between Landlord and Tenant.



 






     


     


    

 


		9.4	Hazardous Materials. Without limiting the generality of the provisions of this Article 9,
Tenant, at its sole cost and expense, shall comply with all statutes, ordinances, rules and regulations of governmental authorities
relating to the storage, use, transportation, release and/or disposal of radioactive materials, hazardous waste, toxic or contaminated
substances or similar materials, including, without limitation, any substances which are “hazardous substances” , “hazardous
waste”, “hazardous materials” or “toxic substances” under applicable federal, state and local environmental
statutes, ordinances, rules or regulations (collectively, “Hazardous Materials”). Tenant shall not store, use, transport,
release or dispose of any Hazardous Materials in, on, from or about the Premises without the prior written consent of Landlord. Tenant
shall be solely responsible for and shall indemnify, defend and hold Landlord and its officers, directors, shareholders, partners, members,
agents, employees, contractors, invitees, representatives, successors and assigns harmless from and against any and all losses, costs,
claims, damages, liabilities and causes of action, including attorneys’ fees, arising out of or in connection with the storage,
use, transportation, release or disposal of Hazardous Materials by Tenant, its employees, agents, contractors or invitees, including any
claims for the clean-up or remediation of any Hazardous Materials. Tenant shall give to Landlord written notice of any communication received
by Tenant from any governmental authority or other party alleging the existing of Hazardous Materials in, on, under or about the Premises
or the Building, or any alleged violation of environmental laws with respect to the Premises or the Building. Without limiting any other
provision of this Lease, Tenant shall provide Landlord with access to the Premises during all reasonable times in order to enable Landlord
to conduct any inspection, monitoring, remediation, removal or repair relating to the presence or alleged presence of Hazardous Materials
in, on under or about the Premises or the Building.



 


		10.	SERVICES AND UTILITIES.



 


		10.1	General. Provided that Tenant is not in default hereunder, Landlord shall:



 


		(a)	Operate or cause the operation of the HVAC system (if any) serving the Premises on generally recognized
business days and during normal business hours reasonably determined by Landlord, subject to the Building rules and regulations,
as required in Landlord’s judgment for the comfortable use and occupancy of the Premises, or as may be permitted or controlled by
applicable statutes, ordinances, rules and regulations of governmental authorities. If Tenant desires HVAC service at any other time,
Landlord shall use reasonable efforts to furnish such service upon reasonable written notice from Tenant, and Tenant shall pay on demand
the charges established by Landlord therefore from time to time (including any administrative fee imposed by Landlord). Tenant agrees
to cooperate fully with Landlord at all times and to abide by all regulations and requirements which Landlord may prescribe for the proper
functioning and protection of the HVAC system, and Landlord shall not be responsible for the failure of the HVAC system to perform its
function due to Tenant’s failure to abide by such regulations and requirements. If Tenant uses heat-generating machines or equipment
in the Premises which affect the temperature otherwise maintained by the HVAC system, Landlord shall have the right to install supplementary
air-conditioning units in the Premises, and the cost thereof, including the cost of installation, operation and maintenance thereof, shall
be paid by Tenant to Landlord upon demand by Landlord;



 






     


     


    

 


		(b)	Make customary arrangements with public utilities and/or governmental authorities to furnish electric
current to the Premises in amount sufficient for normal lighting by overhead florescent fixtures and for normal desktop office equipment
and copying equipment. Tenant shall not, without the prior written consent of Landlord, use any apparatus or device in the Premises, including,
without limitation, electronic data processing equipment, special communications equipment, special lighting or any other electrical equipment,
which consumes more electricity than is usually furnished or supplied for the use of premises as general office space, as determined by
Landlord. Tenant shall not connect any apparatus or device with electric current except through existing electrical outlets in the Premises.
Landlord shall have no obligation to install dedicated circuits or other special circuitry or wiring. Tenant shall advise Landlord prior
to execution of this Lease and thereafter within five (5) days after written request therefore from Landlord of the nature and quantity
of all lights, equipment and machines using electricity in the Premises. If Landlord determines that Tenant is using excessive electricity,
Landlord shall have the right to install an electric current meter in or with respect to the Premises in order to measure the amount of
electricity consumed on the Premises. The cost of any such meter, any conduits, wiring, panels and other equipment required in connection
with such meter, and the installation, maintenance and repair thereof, shall be paid by Tenant to Landlord promptly upon demand, together
with the cost of any excessive electricity consumed by Tenant. If Landlord shall not install a separate meter, the excessive electricity
shall be determined by Landlord or, at Landlord’s option, established by an estimate by a utility company or an electrical engineer
retained by Landlord at Tenant’s expense;



 


		(c)	Provide access to water in the restrooms on each floor for drinking and lavatory purposes only; if Tenant
requires, uses or consumes water for any purposes in addition to ordinary drinking and lavatory purposes, or in excess of the amount thereof
usually furnished or supplied for the use of premises as general office space, as determined by Landlord, Landlord shall have the right
to install a separate water meter in or with respect to the Premises in order to measure the amount of water consumed by Tenant. The cost
of any such meter, and the installation, maintenance, and repair thereof, shall be paid by Tenant to Landlord promptly upon demand, together
with the cost of any excessive water consumed by Tenant. If Landlord shall not install a separate meter, the excessive water shall be
determined by Landlord or, at Landlord’s option, established by an estimate by a utility company or a consultant retained by Landlord
at Tenant’s expense;



 






     


     


    

 


		(d)	Maintain and keep lighted the common stairs, common entries and restrooms in the Common Areas of the Building;
and



 


		(e)	Furnish elevator service, lighting replacement for building standard lights, restroom supplies, window
washing and janitorial service to the extent and in such manner as such services are customarily furnished to comparable office buildings
in San Francisco, California.



 


		10.2	Supplementary Services. Tenant shall pay to Landlord upon demand, at the charges established by
Landlord from time to time, the cost of all supplementary services provided by Landlord to Tenant at Tenant’s request, which services
are in addition to those which Landlord is obligated to provide under this Lease, together with an administrative fee payable to Landlord
in the amount established by Landlord from time to time. Such supplementary services shall include, without limitation, maintenance, repair,
janitorial, cleaning and other services provided during hours other than ordinary business hours and/or in amounts reasonably considered
by Landlord to be in excess of the normal and customary usage thereof for the use of the Premises authorized by this Lease.



 


		10.3	Interruption of Services. Landlord shall not be in default under this Lease or liable for any damages
directly or indirectly resulting from (a) the installation, use or interruption of use of any equipment in connection with the furnishing
of any of the foregoing services; or (b) the failure to furnish or delay in furnishing any such services, where such failure is caused
by any act of God or the elements; a shortage or unavailability of necessary materials, supplies or labor; a shortage or interruption
in transportation facilities; riots; civil disturbances; insurrection; war; court order; public enemy; accidents; breakage; strikes, lockouts
or other labor disputes; the making of repairs, replacements, alterations, additions or improvements to the Premises or the Building;
the inability to obtain an adequate supply of fuel, gas, steam, water, electricity or other utilities or services; or any other condition
beyond Landlord’s reasonable control, and Tenant shall not be entitled to any damages resulting from such failure or to any diminution
or abatement in any Rent or other amounts payable by Tenant hereunder. In no event shall such failure be construed as a constructive or
other eviction of Tenant. If any governmental authority promulgates or revises any statute, ordinance or building, fire or other code,
or imposes mandatory controls or guidelines on Landlord or the Building or any part thereof related to the use or conservation of energy,
water, gas, steam, light or electricity or the provision of any other utility or service provided under this Lease, Landlord may, in its
sole discretion, comply with such mandatory controls or guidelines. If at any time, the owners of a significant number of buildings in
San Francisco, California comparable to the Building have elected to comply voluntarily with any request or guideline of any applicable
governmental authority, Landlord may also comply with such request or guideline. Such compliance shall in no event entitle Tenant to any
damages, or any diminution or abatement in any Rent or other amounts payable by Tenant under this Lease or constitute or be construed
as a constructive or other eviction of Tenant. Tenant shall comply with all rules, regulations and requirements of applicable governmental
authorities or utility companies concerning the use of utility services, including any rationing, limitation or other control on the quantity
of utilities used or consumed.



 






     


     


    

 


		11.	CONDITION OF THE PREMISES.



 


Prior to the Commencement Date, Landlord
shall complete the Landlord’s Work as outlined in Exhibit C at its sole cost and expense. Tenant acknowledges that Tenant is
fully informed independently of Landlord as to the character, construction and structure of the Building and the Premises. Tenant's taking
possession of the Premises (whether before or after the Scheduled Commencement Date) shall constitute Tenant’s acceptance of the
Premises and acknowledgment that any Tenant Improvements were constructed in accordance with the provisions of this Lease and that the
Premises are in good order and satisfactory condition. Tenant shall accept the Premises subject to all applicable statutes, ordinances,
rules and regulations of governmental authorities governing and regulating the use or occupancy of the Premises, including, without
limitation, all applicable zoning, planning, environmental and land use statutes, ordinances, rules and regulations. Tenant acknowledges
that neither Landlord nor Landlord’s employees, agents or contractors have made any representation or warranty as to the suitability
of the Premises for the conduct of Tenant’s business or the consistency of Tenant’s proposed use of the Premises with any
applicable zoning, planning, environmental or land use statutes, ordinances, rules or regulations. No promise of Landlord to alter,
remodel, repair or improve the Premises or the Building, and no representation or warranty, express or implied, with respect to any matter
or thing relating to the Premises, the Building or this Lease (including, without limitation, the condition of the Premises or the Building)
has been made to Tenant by Landlord or its agents, employees or contractors other than as may be contained herein.


 


		12.	REPAIRS AND MAINTENANCE.



 


		12.1	Landlord's Obligation. Subject to the provisions of Section 12.2, Landlord shall repair and
maintain in good order, condition and repair (i) the structural portions of the Building, (ii) the mechanical, HVAC system,
plumbing, and electrical equipment servicing the Building, and (iii) the elevators, and (iv) the Common Areas, in reasonably
good order and condition, except for damage occasioned by the negligence of intentional acts of Tenant, which damage shall be repaired
at Tenant’s expense.



 






     


     


    

 


		12.2	Tenant's Obligation.



 


		(a)	Except as provided in Section 12.1
above, Tenant at Tenant’s sole cost and expense, shall maintain and repair the Premises, keeping the same in good order, condition
and repair, at all times during the Term and, upon expiration of the Term, surrender the same to Landlord in as good a condition as when
leased, reasonable wear and tear, damage by fire, other insured casualty or the elements not caused by Tenant, its agents, employees,
invitees, and licensees excepted. Tenant's obligations shall include, without limitation, (i) the obligation to maintain and when
necessary, repair the Premises interior surfaces of the ceilings, fixtures, walls, floors, doors, door locks, doorframes, entrances,
windows, window frames, and plate glass, (ii) the obligation to maintain and repair the Premises from damage which results from
or is caused by Tenant, its agents, employees, invitees and licensees. This includes the Premises portion of any utility outlets, any
electrical, plumbing, sewer and other utility lines, equipment and systems, whether installed or furnished by Landlord or Tenant, located
in or serving the Premises; and all special items and equipment installed by or at the expense of Tenant. Notwithstanding the above,
and excluding any damage caused by Tenant, its employees or invitee, Landlord will maintain and repair the Building HVAC, and other systems,
serving the entire building as part of the general building maintenance costs of which Tenant has a prorate responsibility for increases
each year



 


		(b)	Tenant shall be responsible for all repairs and alterations in and to the Premises and Building and the
facilities and systems thereof, the need for which arises out of (i) Tenant's use or occupancy of the Premises, (ii) the installation,
removal, use or operation of any Alterations (as defined below) or any of Tenant’s equipment, machinery, trade fixtures, furniture
or other personal property in the Premises, (iii) the moving of Tenant's equipment, machinery, trade fixtures, furniture or other
personal property into or out of the Building, or (iv) the negligent or willful act or omission of Tenant, its agents, contractors,
employees or invitees.



 


		(c)	If Tenant fails to repair and maintain the Premises in good order, condition and repair, then Landlord
shall have the right to do such acts and expend such funds at the expense of Tenant as are reasonably required to perform the work or
repair and maintenance. Any amount so expended by Landlord shall be paid by Tenant promptly after demand with interest at the Interest
Rate from the date of such work. Landlord shall have no liability to Tenant for any damage, inconvenience or interference with the use
of the Premises by Tenant as a result of performing any such work.



 


		12.3	Compliance with Law. Landlord and Tenant shall each do all acts required to comply with all applicable
statutes, ordinances, rules and regulations of any governmental authority relating to the performance of their respective repair
and maintenance obligations as set forth herein.



 


		12.4	Waiver by Tenant. Tenant expressly waives the benefits of any statute now or hereafter in effect
which would otherwise afford Tenant the right to make repairs at Landlord's expense or to terminate this Lease because of Landlord's failure
to keep the Premises in good order, condition and repair, including, without limitation, Sections 1932, 1941 and 1942 of the California
Civil Code or any other, similar statute, ordinance, rule or regulation now or hereafter in effect.



 


		12.5	Load and Equipment Limits. Tenant shall not place a load upon any floor of the Premises which exceeds
the load per square foot which such floor was designed to carry, as determined by Landlord or Landlord's structural engineer. The cost
of any such determination made by Landlord's structural engineer shall be paid for by Tenant upon demand. Tenant shall not install machines
or equipment that cause noise or vibration to such a degree as to be objectionable to Landlord or other Building tenant or occupant.



 






     


     


    

 


		12.6	Landlord Not Liable. Except as otherwise expressly provided in this Lease, Landlord shall have
no liability to Tenant, and Tenant’s obligations under this Lease shall not be reduced or abated in any manner whatsoever, by reason
of any inconvenience, annoyance, interruption or injury to business arising from Landlord’s making any repairs or changes which
Landlord is required or permitted by this Lease or by any other tenant’s lease or required by law to make in or to any portion of
Building or the Premises. Landlord shall nevertheless use reasonable efforts to minimize any interference with Tenant’s business
in the Premises to the extent reasonably possible. In no event shall Landlord be liable to Tenant for any consequential damages regardless
of the cause of such damages.



 


		12.7	Notice of Condition. Tenant shall give Landlord prompt notice of any damage to or defective condition
in the Building's mechanical, electric, plumbing, HVAC or other systems serving or located in the Premises.



 


		13.	ALTERATIONS



 


		13.1	General. Tenant shall not make any additions, structural alterations, non-structural alterations
in excess of $10,000.00, or improvements to the Premises (collectively, “Alterations”), including, without limitation, those
required by Tenant in order to prepare the Premises for Tenant’s occupancy or to enable Tenant to conduct its business therein,
without obtaining the prior written consent of Landlord. In no event shall Tenant make any Alterations to the Premises which affect the
structural integrity of the Building or the functioning of any Building systems, or which reduce the value of the Premises or the Building.
In the event that Tenant shall desire to make any Alterations, Tenant shall submit to Landlord such information as Landlord may require
prior to the commencement of construction or installation of such Alterations, including, without limitation, plans and specifications
for the Alterations and the identity and qualifications of Tenant’s proposed contractor. The plans and specifications for the Alterations,
Tenant’s proposed contractor and the time for performance of the Alterations shall be subject to Landlord’s prior written
approval. Tenant shall reimburse Landlord for Landlord’s costs of considering Tenant’s requests for approval of any such Alterations,
including any cost or expense which Landlord may incur in electing to have architects and engineers review plans and specifications, and
the administration by Landlord or its agent of the construction or installation of the Alteration. Subsequent to obtaining Landlord’s
consent and prior to commencement of construction or installation of the Alterations, Tenant shall deliver to Landlord copies of the building
permit and executed construction contract covering the Alterations. Landlord’s consent may be conditioned upon Tenant's removing
any such Alterations upon the expiration or earlier termination of this Lease and restoring the Premises to the same condition as on the
Commencement Date, provided that Landlord provides at least ten (10) days’ notice prior to the installation of any such Alterations
that such Alterations must be so removed. If the Landlord consents to such alterations and does not provide prior notice as to the required
removal of such Alterations, Tenant shall not be responsible for removing any such Alterations upon the expiration or earlier termination
of this Lease. All work with respect to any Alterations shall be done in a good and workmanlike manner by the contractor approved by Landlord,
shall comply with all applicable statutes, ordinances, rules and regulations of governmental authorities having jurisdiction thereof,
and shall be diligently prosecuted to completion. At Landlord’s option, Landlord shall have the right to construct the Alterations
for Tenant’s account at the same price and on the same terms as a contractor selected by Tenant, if any. If Landlord so elects,
Tenant shall reimburse Landlord for any and all costs thereof (including, without limitation, the costs of design, labor, materials, equipment,
and a construction fee of six percent (6%) of the total cost of construction of the Alterations) within ten (10) days after receipt
of Landlord’s invoice.



 






     


     


    

 


		13.2	Construction Indemnity. Tenant shall pay the costs of any work done on the Premises pursuant to
Section 13.1 and shall keep the Premises and Building free and clear of liens of any kind. Tenant shall indemnify, defend, and hold
Landlord harmless from and against any and all losses, costs, claims, damages, liabilities and causes of action (including attorneys’
fees) arising out of or in any way connected with Tenant’s performance of any work of construction, alteration, addition, improvement,
repair or maintenance in the Premises, or claims for work or labor performed, or materials or supplies furnished, to or at the request
of Tenant or in connection with the performance of any work done for the account of Tenant in the Premises or the Building, whether or
not Tenant obtained Landlord’s permission to have such work done, labor performed or materials or supplies furnished.



 


		13.3	Notices. At least twenty (20) days prior to the actual commencement of any work for which a claim
or lien may be filed, Tenant shall give Landlord written notice of the intended commencement date to enable Landlord to post and/or record
notices of non-responsibility or any other notices which Landlord deems necessary for the proper protection of Landlord's interest in
the Premises or the Building, and Landlord shall have the right to enter the Premises and post such notices at any reasonable time.



 


		13.4	Bonds. Landlord, at Landlord's option, shall have the right to require that Tenant provide to Landlord,
at Tenant's expense, payment and/or performance bonds in an amount equal to at least one and one-half (1-1/2) times the total estimated
costs of any Alterations to be made in or to the Premises to protect Landlord against any liability for mechanic's and materialmen's liens
and to insure timely completion of the work. Nothing contained in this Section 13.4 shall relieve Tenant of its obligation under
Section 13.2 to keep the Premises and the Building free of all liens.



 


		13.5	Removal. Unless their removal is required by Landlord as provided in Section 13.1, all Alterations
shall become the property of Landlord and shall be surrendered with the Premises upon the expiration of the Term or earlier termination
of this Lease; provided, however, that Tenant's equipment, machinery and trade fixtures which can be removed without damage to the Premises
shall remain the property of Tenant and may be removed by Tenant; provided, however, that if Tenant shall remove any such equipment, machinery
or trade fixtures, Tenant shall promptly repair any damage to the Premises or to the Building resulting from such removal, and shall return
the Premises and/or the Building to their condition prior to the installation of any such equipment, machinery or trade fixtures.



 






     


     


    

 


		13.6	Common Area Provisions. Tenant shall not use any portion of the Common Areas or any other portion
of Building other than the Premises in connection with the making of any Alterations without Landlord’s prior written consent. If
any Alterations that Tenant shall construct result in Tenant or Landlord being required to make any alterations, additions or improvements
to the Premises, or in Landlord being required to make any alterations, additions or improvements to any other portions of the Building,
in any case in order to comply with applicable statutes, ordinances, rules or regulations of governmental authorities, including,
without limitation, the Americans with Disabilities Act, Title 24 or any regulations promulgated thereunder, or any similar state or local
statutes, ordinances, rules or regulations, then Tenant shall be obligated to make all such alterations, additions or improvements,
or, at Landlord’s option, Tenant shall reimburse Landlord upon demand for all cost and expense incurred by Landlord making such
alterations, additions or improvements.



 


		14.	RULES AND REGULATIONS.



 


Tenant shall comply with (and shall
cause its agents, contractors, employees and invitees to comply with) the rules and regulations attached hereto as Exhibit “B”
and with such modifications thereof and additions thereto as Landlord may from time to time reasonably make. Landlord shall not be responsible
for any violation of such rules and regulations by other tenants or occupants of the Building. In the event of any conflict between
such rules and regulations and the provisions of this Lease, the provisions of this Lease shall prevail and be controlling.


 


		15.	ENTRY BY LANDLORD.



 


Landlord shall have the right to enter
the Premises by giving Tenant 24 hours written notice, except in the event of an emergency in which event no notice shall be required,
to: (a) inspect the Premises; (b) exhibit the same to prospective purchasers, lenders or tenants; (c) determine whether
Tenant is complying with all of its obligations hereunder; (d) provide janitorial service and any other service to be provided by
Landlord to Tenant hereunder; (e) post notices of non-responsibility; and (f) make repairs required of Landlord under the terms
hereof or make repairs to any adjoining space or utility services (including checking, adjusting, calibrating or balancing the HVAC system)
or make repairs, alterations or improvements to any other portion of the Building. Tenant hereby waives any claim for damages for any
injury or inconvenience to or interference with Tenant’s business, any loss of occupancy or quiet enjoyment of the Premises, and
any other loss occasioned by such entry, provided that Landlord takes reasonable steps to minimize the interference with Tenant’s
use and enjoyment of the Premises. Landlord shall at all times have and retain a key with which to unlock all of the doors in, on or about
the Premises (including Tenant’s vaults, safes and similar areas agreed upon in writing by Tenant and Landlord). Landlord shall
have the right to use any and all means which Landlord may deem appropriate to open such doors in an emergency in order to obtain entry
to the Premises, and no entry to the Premises obtained by Landlord by any of such means shall under any circumstance be construed or deemed
to be a forcible or unlawful entry into, or a detainer of, the Premises or an eviction, actual or constructive, of Tenant from the Premises,
or any portion thereof.


 






     


     


    

 


		16.	ASSIGNMENT AND SUBLEASE.



 


		16.1	General. Tenant shall not, voluntarily, involuntarily or by operation of law, without the prior
written consent of Landlord: (a) assign, mortgage, pledge, hypothecate, encumber or otherwise transfer Tenant’s leasehold interest
under this Lease; (b) permit the Premises or any part thereof to be used or occupied by anyone other than Tenant (whether as concessionaire,
franchisee, licensee or otherwise); or (c) sublease or offer or market for sublease the Premises or any part thereof. Subject to
the provisions of this Article 16, Landlord shall not unreasonably withhold its consent to a proposed assignment or sublease. Any
of the foregoing acts done without Landlord’s consent shall be void and shall, at the option of Landlord, terminate this Lease.
If Tenant is a corporation, any dissolution, merger, or consolidation or other reorganization of Tenant, shall be deemed an assignment
of this Lease by Tenant for which Landlord’s written consent to assignment is required, such consent not to be unreasonably withheld.
If Tenant is a partnership or limited liability company, a withdrawal or change, voluntarily, involuntarily or by operation of law, of
any general partner or any manager or managing member, as applicable, or any partner or partners or member or members, as applicable,
owning a total of fifty-one percent (51%) or more of the partnership interest of such partnership or membership interest of such limited
liability company, as applicable, or the dissolution of the partnership or limited liability company, shall be deemed an assignment of
this Lease by Tenant for which Landlord’s written consent is required.



 


Tenant shall not have the right to assign
this Lease or sublease the Premises or any portion thereof, without Landlord's consent and without allowing Landlord to exercise the rights
set forth in Section 16.2 (a), (b) or (c) below, to any corporation which controls, is controlled by or is under common
control with Tenant, or to any corporation resulting from a merger or consolidation with Tenant, or to any person or entity which acquires
all of the assets of Tenant's business as a going concern.


 


		16.2	Notice and Procedure. If at any time or from time to time during the Term, Tenant desires to assign
this Lease or sublease all or any part of the Premises, at least thirty (30) days prior to the date on which Tenant desires the assignment
or sublease to be effective (“Transfer Date”), Tenant shall give written notice to Landlord setting forth the terms and provisions
of the proposed assignment or sublease, the identity of the proposed assignee or subtenant and the space proposed to be assigned or subleased
(“Subject Space”). Tenant shall promptly supply Landlord with such information concerning the business background and financial
condition of such proposed assignee or subtenant, and such additional information concerning the proposed assignment or sublease, as Landlord
may reasonably request, and Tenant’s notice shall not be deemed to have been given until Landlord receives such information. Landlord
shall have the option, exercisable by notice given to Tenant within fourteen (14) days after Landlord’s receipt of Tenant's notice
and receipt of applicable additional information, (a) in the case of an assignment or sublease, to terminate this Lease as to the
Subject Space as of the Transfer Date, (b) in the case of a sublease, to sublease the Subject Space from Tenant on the terms and
provisions set forth in Tenant’s notice, or (c) consent or decline to consent to the proposed assignment or sublease in accordance
with the provisions of this Article 16.



 






     


     


    

 


		16.3	Landlord’s Consent. Landlord shall be entitled to consider any reasonable factor in determining
whether or not to consent to a proposed assignment or sublease. Without limiting any other circumstances in which it may be reasonable
for Landlord to withhold its consent to a proposed assignment or sublease, Tenant acknowledges and agrees that it shall be reasonable
for Landlord to withhold its consent to a proposed assignment or sublease under any of the following circumstances:



 


		(a)	The financial condition of the proposed assignee or subtenant shall not be equal to or greater than Tenant’s
financial condition as of the date hereof or shall not satisfy Landlord’s then-current credit standards for tenants of the Building,
or the proposed assignee or subtenant shall not otherwise have the financial capacity to perform all obligations under this Lease to be
performed by Tenant;



 


		(b)	The proposed use of the Premises by the proposed assignee or subtenant shall (i) not comply with
the provisions of Article 9 hereof, (ii) not be consistent with the general character of businesses carried on by tenants of
a first-class office building, (iii) increase the likelihood of damage or destruction to the Premises or Building, (iv)  increase
the density of occupancy of the Premises, (v) be likely to cause an increase in insurance premiums for insurance policies carried
by Landlord with respect to the Building, or (vi) otherwise adversely impact the Premises, the Building or Landlord’s interest
therein; or



 


		(c)	Any mortgagee or beneficiary under a deed of trust whose consent to the assignment or sublease is required
shall not consent thereto.



 


		16.4	Conditions. If Landlord consents to an assignment or sublease in writing, Tenant shall be entitled
to assign or sublease the Subject Space to the proposed assignee or subtenant, subject to the following conditions:



 


		(a)	As of the effective date of such assignment or sublease, Tenant shall not be in default under this Lease;



 


		(b)	The assignment or sublease shall be on the same terms set forth in Tenant’s notice given to Landlord;



 


		(c)	No assignment or sublease shall be valid, and no assignee or subtenant shall take possession of the Premises
or any portion thereof until an executed counterpart of such assignment or sublease has been delivered to Landlord;



 


		(d)	No assignee or subtenant shall have a further right to assign or sublease;



 


		(e)	Any proposed sublease would not result in more than two subleases of portions of the Premises being in
effect during the term;



 


		(f)	Any assignee shall have assumed in writing the obligations of Tenant under this Lease;



 


		(g)	Any subtenant shall have agreed in writing to comply with all applicable terms and provisions of this
Lease; and



 






     


     


    

 


		(h)	Fifty Percent (50%) of any sums or other economic consideration received by Tenant as a result of such
assignment or sublease, however denominated under the assignment or sublease, which exceed, in the aggregate, Base Rent which Tenant is
obligated to pay Landlord under this Lease (prorated as to any sublease to reflect obligations allocable to that portion of the Premises
subject to such sublease), after deducting Tenant’s transaction costs, including but limited to Tenant’s cost of tenant improvements,
brokerage commissions and reasonable legal fees, shall be paid to the Landlord as additional rent under this Lease without affecting or
reducing any other obligations of Tenant hereunder. At Landlord’s request Tenant shall deliver to Landlord such evidence of the
sums or other economic consideration received by Tenant as a result of the assignment or sublease as Landlord shall require from time
to time.



 


		16.5	Continuing Liability. Regardless of Landlord’s consent, no sublease or assignment shall release
Tenant from any of Tenant's obligations under this Lease, or alter, impair or diminish the primary liability of Tenant to pay the Rent
and to perform all other obligations to be performed by Tenant hereunder. The acceptance of Rent by Landlord from any other person shall
not be deemed to be a waiver by Landlord of any provisions hereof. Consent to one assignment or sublease shall not be deemed consent to
any subsequent assignment or sublease. In the event of a default by an assignee or subtenant of Tenant or any successor of Tenant in the
performance of any of the terms hereof, Landlord may proceed directly against Tenant without the necessity of exhausting remedies against
such assignee, subtenant or successor. Landlord may consent to subsequent assignments of the Lease or subleases or amendments or modifications
of the Lease with assignees of Tenant, without notifying Tenant or any successor of Tenant, and without obtaining its or their consent
thereto, and any such actions shall not relieve Tenant of liability under this Lease. If Tenant assigns the Lease or subleases the Premises
or requests the consent of Landlord to any assignment or sublease, then Tenant shall, upon demand, pay Landlord an administrative fee
of Five Hundred Dollars ($500) plus any attorneys’ fees incurred by Landlord up to a maximum of Two Thousand Five Hundred Dollars
($2,500) per occurrence in connection with such act or request.



 


		17.	HOLDING OVER.



 


If after expiration of the Term or earlier
termination of this Lease, Tenant remains in possession of the Premises with Landlord's express permission. Tenant shall become a tenant
from month-to-month only, upon all the provisions of this Lease (except as to term and Base Rent), including the obligation to pay Tenant’s
Proportionate Share of Excess Operating Costs and Tenant’ Proportionate Share of Excess Taxes, but the Rent payable by Tenant shall
be increased to one hundred fifty percent (150%) of the Rent payable by Tenant at the expiration of the Term or earlier termination of
this Lease. Such monthly Rent shall be payable in advance on or before the first day of each month. Tenant shall indemnify, defend and
hold Landlord harmless from and against any and all claims, losses, liabilities, damages, costs and liabilities (including attorneys’
fees) resulting from Tenant’s failure to surrender possession, including, without limitation, any claims made by any succeeding
tenant.


 






     


     


    

 


		18.	SURRENDER OF PREMISES.



 


At the expiration of the Term or upon
earlier termination of this Lease, Tenant shall peaceably surrender possession of the Premises to Landlord in broom-clean condition and
in as good condition as when Tenant took possession, except for reasonable wear and tear. Tenant shall have the right to remove from the
Premises any of Tenant’s machinery, equipment, trade fixtures or furnishings which may be removed without causing damage to the
Premises, and, subject to Section 13.1 herein, Tenant shall remove any Alterations and any other alterations, additions, improvements,
machinery, equipment, trade fixtures or furnishings installed by Tenant which Landlord shall direct to be removed in accordance with the
provisions of this Lease. Tenant shall not be obligated to remove any Alterations or any other alterations, additions, improvements, machinery,
equipment, trade fixtures or furnishings that Tenant did not install, and more specifically shall not be required to remove the prior
tenant’s cabling currently in place. Tenant shall promptly repair any damage to the Premises or the Building caused by any such
removal. Any personal property of Tenant not removed from the Premises shall be deemed to have been abandoned by Tenant and, at Landlord’s
option, shall thereupon become the property of Landlord. If Landlord elects to remove all or any part of Tenant’s personal property,
the cost of removal, including the cost of repairing any damage to the Premises or the Building caused by such removal, and the cost of
any storage shall be paid by Tenant. At the expiration of the Term or upon any earlier termination of this Lease, Tenant shall surrender
all keys to the Premises to the Landlord. No act or conduct of Landlord, including, without limitation, the acceptance of keys to the
Premises, shall constitute an acceptance of the surrender of the Premises by Tenant before the expiration of the Term. Only a written
notice from Landlord to Tenant shall constitute acceptance of the surrender of the Premises and accomplish a termination of the Lease.


 


		19.	DESTRUCTION OR DAMAGE.



 


		19.1	Insured Casualty. If the Premises or the portion of the Building necessary for Tenant's occupancy
are damaged by fire, earthquake, act of God, the elements or other casualty, and Landlord shall have received insurance proceeds sufficient
to fully repair and restore the Premises and Building, Landlord shall, subject to the provisions of this Article, promptly repair the
damage, if such repairs can, in Landlord's opinion, be completed within ninety (90) days after commencement of work. If Landlord reasonably
determines that repairs can be completed within ninety (90) days after commencement of work, this Lease shall remain in full force and
effect, except that if such damage is not the result of the negligence or willful misconduct of Tenant or Tenant's agents, employees,
contractors, licensees or invitees, the Base Rent shall be abated to the extent Tenant's use of the Premises is impaired, commencing with
the date of damage and continuing until completion of the repairs. If, in Landlord's reasonable opinion, such repairs to the Premises
or portion of the Building necessary for Tenant's occupancy cannot be completed within ninety (90) days after commencement of work, either
Tenant or Landlord may elect, upon notice to the other party given within thirty (30) days after the date of damage, to terminate this
Lease.



 






     


     


    

 


		19.2	Uninsured Casualty. If the Premises or the portion of the Building necessary for Tenant’s
occupancy are damaged by fire, earthquake, act of God, the elements or other casualty, and Landlord shall not have received insurance
proceeds sufficient to fully repair and restore the Premises and Building, Landlord shall, subject to the provisions of this Article,
promptly repair the damage, if such repairs can, in Landlord's opinion, be completed within ninety (90) days after commencement of work.
If Landlord reasonably determines, within a period of thirty (30) days after the occurrence of the damage, that repairs can be completed
within ninety (90) days after commencement of work, this Lease shall remain in full force and effect, except that if such damage is not
the result of the negligence or willful misconduct of Tenant or Tenant's agents, employees, contractors, licensees or invitees, the Base
Rent shall be abated to the extent Tenant's use of the Premises is impaired, commencing with the date of damage and continuing until completion
of the repairs. If such damage is the result of the negligence or willful misconduct of Tenant or Tenant's agents, employees, contractors,
licensees or invitees, no Base Rent will be abated and Tenant shall be liable for all repair costs relating to the damages. If, in Landlord's
reasonable opinion, such repairs to the Premises or portion of the Building necessary for Tenant's occupancy cannot be completed within
ninety (90) days after commencement of work, whether due to cost or complexity of such repairs, or Landlord fails to make such a determination
within thirty (30) days after the occurrence of the occurrence of such damage, either Tenant or Landlord may elect, upon notice to the
other party given within thirty (30) days after the date of damage, to terminate this Lease.



 


		19.3	Building. If any other portion of the Building is damaged, Landlord may elect, upon notice to Tenant
given within thirty (30) days after the date of such damage (but shall not be obligated), to repair such damage, in which event this Lease
shall continue in full force and effect. If Landlord shall not elect to make such repairs, Landlord shall have the right to terminate
this Lease as of the date of expiration of such thirty (30) day period.



 


		19.4	Liability for Tenant’s Property. In no event shall Landlord have any liability for, and in
no event shall Landlord be required to repair or restore, any damage to or destruction of any Alterations or any machinery, equipment,
trade fixtures, furniture or other property installed by or at the expense of Tenant or otherwise located in the Premises. If Landlord
shall not elect to terminate this Lease pursuant to this Article, Tenant shall promptly repair or restore all such property to the condition
existing immediately prior to the event of damage. Landlord shall not be liable for any loss of business, inconvenience or annoyance arising
from any repair or restoration of any portion of the Premises or Building as a result of any damage from fire or other casualty.



 


		19.5	Waiver of Remedies. Landlord and Tenant acknowledge and agree that the rights and obligations of
the parties in the event of the damage or destruction of the Premises shall be as set forth in this Article. Tenant hereby expressly waives
any rights to terminate this Lease upon damage or destruction of the Premises or the Building, except as expressly provided by this Lease,
including, without limitation, any rights pursuant to the provisions of Sections 1932(2) and 1933(4) of the California Civil
Code, as amended, or any other similar provisions of law.



 


		20.	EMINENT DOMAIN.



 


		20.1	Taking. If the entire Building or Premises is taken by condemnation or in any other lawful manner
for any public or quasi-public purpose, this Lease shall terminate as of the date of such taking, and Rent shall be prorated to such date.
If less than the entire Building or Premises is so taken, this Lease shall be unaffected by such taking, provided that (a) Tenant
shall have the right to terminate this Lease by notice to Landlord given within thirty (30) days after the date of such taking if twenty
percent (20%) or more of the Premises is taken and the remaining area of the Premises is not reasonably sufficient for Tenant to continue
operation of its business, and (b) Landlord shall have the right to terminate this Lease by notice to Tenant given within thirty
(30) days after the date of such taking. If either Landlord or Tenant elects to terminate this Lease, the Lease shall terminate thirty
(30) days after such notice. The Rent shall be prorated to the date of termination. If this Lease shall not be terminated upon such partial
taking, the Base Rent and Tenant's Proportionate Share shall be equitably adjusted according to the remaining Rentable Area of the Premises
and Building.



 






     


     


    

 


		20.2	Temporary Taking. If the Premises shall be temporarily condemned or taken for governmental occupancy
for a period of more than one year, this Lease shall terminate as of the date of taking, and Landlord shall be entitled to any and all
compensation, damages, income, rent and awards in connection therewith. If the Premises shall be temporarily taken for a period of one
year or less, this Lease shall remain in full force and effect, but any condemnation award as a result of such taking shall be payable
to Tenant.



 


		20.3	Condemnation Award. In the event of any taking, all of the proceeds of any award, judgment or settlement
payable by the condemning authority shall be the exclusive property of Landlord, and Tenant hereby assigns to Landlord all of its right,
title and interest in any award, judgment or settlement from the condemning authority. Tenant, however, shall have the right, to the extent
that Landlord's award is not reduced or prejudiced, to claim from the condemning authority (but not from Landlord) such compensation as
may be recoverable by Tenant in its own right for relocation expenses and damage to Tenant's personal property. In no event shall Tenant
be entitled to receive any award for any “bonus value” of this Lease or otherwise attributable to the value of Tenant’s
interest under this Lease or in or to the Premises. Each party hereby waives the provisions of California Code of Civil Procedure Sections
1265.120 and 1265.130 allowing either party to petition the Superior Court to terminate this Lease in the event of a partial taking of
the Premises.



 


		20.4	Restoration. In the event of a partial taking of the Premises which does not result in a termination
of this Lease, Landlord shall restore the remaining portion of the Premises as nearly as practicable to its condition prior to the condemnation
or taking, but only to the extent of the portion of the condemnation award expressly made to Landlord for the purpose of making such restoration
to the Premises. Tenant shall be responsible at its sole cost and expense for the repair, restoration and replacement of any Alterations
or any of Tenant’s machinery, equipment, trade fixtures, furniture or other personal property of Tenant.



 






     


     


    


 


		21.	INDEMNIFICATION; WAIVER.



 


		21.1	Tenant’s Indemnity. Tenant shall indemnify, defend and hold Landlord and Landlord’s
employees, agents or contractors harmless against and from losses, costs, claims, damages, liabilities or causes of action (including
attorneys’ fees) arising out of or in any way connected with: (a) Tenant’s use or occupancy of the Premises or the conduct
of Tenant’s business thereon, or any work, activity or other things allowed or suffered by Tenant to be done in, on or about the
Premises; (b) any breach or default by Tenant in any of Tenant's obligations under this Lease; (c) any negligent or willful
act or omission of Tenant, its agents, employees, invitees or contractors; or (d) any damage to any property or injury, illness or
death of any person occurring in, on or about the Premises, or any part thereof, arising at any time and from any cause whatsoever. As
a material part of the consideration for Landlord's execution of this Lease, Tenant hereby assumes all risk of damage or injury to any
person or property in, on or about the Premises from any cause whatsoever.



 


		21.2	Landlord’s Indemnity. Landlord shall indemnify, defend and hold Tenant and Tenant’s
employees, agents or contractors harmless against and from losses, costs, claims, damages, liabilities or causes of action (including
attorneys’ fees) caused by Landlord’s gross negligence or willful misconduct.



 


		21.3	Waiver. Neither Landlord nor Landlord’s agents, employees or contractors shall be liable
for, and Tenant hereby waives all claims against Landlord and such other parties with respect to, any injury or damage which may be sustained
by the person or property of Tenant, its employees, agents, invitees or customers, or any other person in or about the Premises, caused
by or resulting from any cause whatsoever, including, without limitation, fire, steam, electricity, gas, water or rain which may leak
or flow from or into any part of the Premises; the breakage, leakage, obstruction or other defects of pipes, sprinklers, wires, appliances,
plumbing, air-conditioning or lighting fixtures; the interruption of any public utility or service; acts of the God or the elements, acts
of public enemy, riot, strike, insurrection, war, court order or order of governmental authority; or explosion, fire or theft, in any
case, whether such damage or injury results from conditions arising upon the Premises or upon other portions of the Building or from other
sources. Neither Landlord nor Landlord's agents, employees or contractors shall be liable for any damages arising from any act or omission
of any other tenant or occupant of the Building. In no event shall Landlord be liable or responsible in any way for any loss of business
by Tenant, lost profits of Tenant or any other consequential damages of Tenant or its employees, agents, invitees or customers, regardless
of the cause thereof.



 


		22.	TENANT'S INSURANCE.



 


		22.1	Throughout the Term, Tenant shall procure, pay for and maintain in effect commercial general liability
insurance with respect to Tenant’s construction of improvements on the Premises; the use, operation or condition of the Premises;
and the operations of Tenant in, on or about the Premises, with a minimum coverage of not less than Three Million Dollars ($3,000,000)
combined single limit for bodily injury, death and property damage liability.



 


		22.2	Property Insurance. Throughout the Term, Tenant shall procure, pay for and maintain in effect a
policy of “all risk” property insurance, with theft, vandalism and malicious mischief endorsements, covering any Alterations
and Tenant’s machinery, equipment, trade fixtures, furniture and other personal property from time to time in, on or about the Premises,
in an amount not less than one hundred percent (100%) of their actual replacement cost from time to time. The proceeds of such insurance
shall be used for the repair or replacement of the property so insured. If this Lease shall terminate following a casualty as set forth
herein, the proceeds of such insurance allocable to Alterations shall be paid to Landlord, and the proceeds of such insurance allocable
to the other property set forth above shall be paid to Tenant.



 



     


     


    




 


		22.3	Additional Insurance. Throughout the Term, Tenant shall procure, pay for and maintain an effect
such additional insurance with such forms of coverage and in such amounts as Landlord shall reasonably require, including, without limitation,
workers’ compensation insurance and employers’ liability insurance as required by law.



 


		22.4	Requirements. All insurance required to be carried by Tenant hereunder shall be issued by responsible
insurance companies acceptable to Landlord and Landlord's lender and qualified to do business in the State of California. Each policy
shall name Landlord, Landlord's agents and, at Landlord's request, any mortgagee of Landlord as an additional insured, as their respective
interests may appear. Each policy shall contain (a) a cross-liability endorsement, (b) a provision that such policy and the
coverage evidenced thereby shall be primary and noncontributing with respect to any policies carried by Landlord and that any coverage
carried by Landlord shall be excess insurance, and (c) a waiver by the insurer of any right of subrogation against Landlord to the
extent required under Section 22.6 below. A copy of each paid up policy (authenticated by the insurer) or certificate of the insurer
evidencing the existence and amount of each insurance policy required hereunder shall be delivered to Landlord before the date Tenant
is first given the right of possession of the Premises, and thereafter within thirty (30) days after any demand by Landlord therefore.
Landlord may, at any time and from time to time, inspect and/or copy any insurance policies required to be maintained by Tenant hereunder.
No such policy shall be cancelable except after thirty (30) days’ written notice to Landlord and Landlord's lender. Tenant shall
furnish Landlord with renewals or "binders" of any such policy at least ten (10) days prior to the expiration thereof.
Tenant agrees that if Tenant does not take out and maintain such insurance, Landlord may (but shall not be required to) procure such insurance
on Tenant's behalf and charge Tenant for the premiums together with interest thereon at the Interest Rate, payable upon demand. Tenant
shall have the right to provide such insurance coverage pursuant to blanket policies obtained by the Tenant, provided such blanket policies
expressly afford coverage to the Premises, Landlord, Landlord's mortgagee and Tenant as required by this Lease.



 


		22.5	Adjustments. Landlord shall have the right, periodically during the Term, but not more frequently
than once each twelve (12) months, to require that Tenant increase the coverage amounts for the insurance that Tenant is obligated
to carry under this Lease to amounts to equal to the then-prevailing coverage amounts required by prudent landlords of comparable office
buildings in San Francisco, California, as determined by Landlord in its reasonable judgment.



 


		22.6	Waiver of Subrogation. Landlord and Tenant each hereby waive all rights of recovery against the
other party, on account of loss by or damage to the waiving party or its property or the property of others under its control, to the
extent that such loss or damage is insured against under any property insurance policy which either may have in force at the time of the
loss or damage. To the extent that such insurance endorsement is available at no or nominal additional premium charge and does not adversely
affect the ability of such party to obtain such insurance, Landlord and Tenant each agree to obtain for the benefit of the other party
in the insurance policies carried by the first party a waiver or any right of subrogation which any insurer of the party may acquire.



 






     


     


    

 


		23.	SUBORDINATION AND ATTORNMENT.



 


		23.1	Subordination of Lease. This Lease shall be subject and subordinate at all times to the lien of
all mortgages and deeds of trust securing any amount now or hereafter encumbering Landlord’s interest in the Premises or Building,
all without the necessity of having further instruments executed on the part of Tenant in order to effectuate such subordination. Upon
the written request of Landlord, Tenant shall execute, acknowledge and deliver to Landlord such further instruments evidencing the subordination
of this Lease to the lien of any such mortgages or deeds of trust as may be required by Landlord, and Tenant shall attorn to any such
mortgagee or beneficiary under any mortgage or deed of trust in the event of a foreclosure or a deed in lieu of foreclosure, or other
purchaser or a grantee in respect thereof; provided, however, that each mortgagee or beneficiary under any such mortgage or deed of trust,
or purchaser or grantee in respect thereof, shall agree not to terminate or disturb Tenant’s possession of the Premises under this
Lease in the event of a foreclosure of such mortgage or deed of trust or a deed in lieu thereof, as long as Tenant is not in default under
this Lease at such time. Notwithstanding the foregoing, any mortgagee or beneficiary under a mortgage or deed of trust may at any time
subordinate its mortgage or deed of trust to this Lease in all or in part, without Tenant’s consent, by execution of a written instrument
subordinating such mortgage or deed of trust to this Lease, in which case this Lease shall be deemed prior to such mortgage or deed of
trust without regard to their respective dates of execution, delivery and/or recording.



 


		23.2	Approval by Lenders. Tenant acknowledges that the provisions of this Lease may be subject to the
approval of any lender that may hereafter make a loan secured by a mortgage or deed of trust on the Premises or Building. If such lender
shall require, as a condition of such financing that modifications be made to this Lease, at Lender’s request, Tenant agrees to
execute appropriate amendments to this Lease to effect such modifications; provided, however, that such modifications shall not change
the size, location or dimensions of the Premises, increase any potential liability for which Tenant might be liable, or increase the amount
of the Rent or the other amounts payable by Tenant under this Lease.



 


		24.	ESTOPPEL CERTIFICATES.



 


Within ten (10) business days after written request
from Landlord, Tenant shall execute and deliver to Landlord or Landlord’s designee a written statement certifying (a) that
this Lease is unmodified and in full force and effect, or is in full force and effect as modified and stating the modifications; (b) the
amount of Base Rent and the date to which Base Rent and additional rent have been paid; (c) the amount of any Security Deposit made
with Landlord; (d) that Landlord is not in default hereunder or, if Landlord is claimed to be in default, stating the nature of any
claimed default; (e) that Tenant is not in default hereunder, or stating such defaults as Tenant shall specify; and (f) certifying
as to such other matters as Landlord may reasonable require. Any such statement may be relied upon by a purchaser, assignee or lender.
Tenant's failure to execute and deliver such statement within the time required shall be conclusive upon Tenant as to the matters set
forth in such statement.


 






     


     


    

 


		25.	TRANSFER OF LANDLORD'S INTEREST.



 


The term “Landlord” as used
herein shall mean only the owner or owners at the times in question of title to the Premises or the Building. In the event of any sale
or transfer by Landlord of the Premises or Building, Landlord shall be and is hereby entirely freed and relieved of any and all liability
and obligations contained in or derived from this Lease, which shall be assumed by the purchaser or transferee upon such sale or transfer
unless otherwise agreed to in writing by Tenant in advance, arising out of any act, occurrence or omission relating to the Premises, Building
or Lease occurring after the consummation of such sale or transfer. If any Security Deposit has been made by Tenant, Landlord may transfer
the Security Deposit to Landlord's successor and upon such transfer, Landlord shall be relieved of further liability with respect thereto.
This Lease shall not be affected by any such sale or transfer, and Tenant agrees to attorn to the purchaser or transferee, such attornment
to be effective and self-operative without the execution of any further instruments on the part of Landlord or Tenant.


 


		26.	DEFAULT.



 


		26.1	Tenant's Default. The occurrence of any one or more of the following events shall constitute a
default and breach of this Lease by Tenant:



 


		(a)	Tenant abandons or vacates the Premises; or



 


		(b)	Tenant fails to pay when due any Rent or any other amounts required to be paid by Tenant under this Lease,
and Tenant fails to cure such lack of payment within ten (10) business days of the date such Rent is due; or



 


		(c)	Tenant fails to perform any other covenant, agreement or obligation contained in this Lease, and such
failure continues for thirty (30) days after written notice thereof from Landlord to Tenant; or



 


		(d)	A writ of attachment or execution is levied on Tenant's interest under this Lease; or



 


		(e)	Tenant makes a general assignment for the benefit of creditor, or provides for an arrangement, composition,
extension or adjustment with its creditors; or



 


		(f)	Tenant files a voluntary petition for relief under the U.S. Bankruptcy Code or any other federal or state
bankruptcy, insolvency or debtor relief laws (collectively, “Insolvency Laws”), or a petition for relief is filed against
Tenant under any Insolvency Laws and not withdrawn or dismissed within forty-five (45) days thereafter; or



 


		(g)	Appointment of a receiver, trustee, custodian or other person to take possession of all or substantially
all of Tenant's assets; or



 


		(h)	Commencement of proceedings for winding up or dissolving (whether voluntary or involuntary) Tenant, if
Tenant is a corporation, partnership or limited liability company.



 






     


     


    

 


		26.2	Remedies. In the event of Tenant's default hereunder, then in addition to any other rights or remedies
Landlord may have under any law, Landlord shall have the right, at Landlord's option, without further notice or demand of any kind to
do the following:



 


		(a)	Terminate this Lease and Tenant's right to possession of the Premises and reenter the Premises and take
possession thereof, and Tenant shall have no further claim to the Premises or under this Lease;



 


		(b)	Continue this Lease in effect, reenter and occupy the Premises for the account of Tenant, and collect
any unpaid Rent or other charges which have or thereafter become due and payable; and/or



 


		(c)	Reenter the Premises under the provisions of subparagraph (b), and thereafter elect to terminate this
Lease and Tenant's right to possession of the Premises.



 


If Landlord reenters the Premises under
the provisions of subparagraphs (b) or (c) above, Landlord shall not be deemed to have terminated this Lease or the obligation
of Tenant to pay any Rent or other amounts payable hereunder, unless Landlord notifies Tenant in writing of Landlord’s election
to terminate this Lease. In the event of any reentry or retaking of possession by Landlord, Landlord shall have the right, but not the
obligation, to remove all or any part of Tenant's personal property in the Premises and to place such property in storage at a public
warehouse at the expense and risk of Tenant. If Landlord elects to relet the Premises for the account of Tenant, the rent received by
Landlord from such reletting shall be applied as follows: first, to the payment of any indebtedness other than Rent due hereunder from
Tenant to Landlord; second, to the payment of any costs of such reletting; third, to the payment of the cost of any alterations or repairs
to the Premises; fourth, to the payment of Rent due and unpaid hereunder; and the balance, if any, shall be held by Landlord and applied
in payment of future Rent as it becomes due. If that portion of rent received from the reletting which is applied against the Rent due
hereunder is less than the amount of the Rent due, Tenant shall pay the deficiency to Landlord promptly upon demand by Landlord. Such
deficiency shall be calculated and paid monthly. Tenant shall also pay to Landlord, as soon as determined, any costs and expenses incurred
by Landlord in connection with such reletting or in making alterations and repairs to the Premises, which are not covered by the rent
received from the reletting.


 


If Landlord shall terminate this Lease
under the provisions of subparagraphs (a) or (c) above, in addition to any of the rights and remedies to which Landlord may
be entitled under applicable law, Landlord may recover as damages from Tenant the following:


 


		(1)	Past Rent. The worth at the time of the award of any unpaid Rent which had been earned at the time
of termination; plus



 






     


     


    

 


		(2)	Rent Prior to Award. The worth at the time of the award of the amount by which the unpaid Rent
which would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could
have been reasonably avoided; plus



 


		(3)	Rent After Award. The worth at the time of the award of the amount by which the unpaid Rent for
the balance of the Term after the time of award exceeds the amount of the rental loss that Tenant proves could be reasonably avoided;
plus



 


		(4)	Proximately Caused Damages. Any other amount necessary to compensate Landlord for all detriment
proximately caused by Tenant's failure to perform its obligations under this Lease or which in the ordinary course of things would be
likely to result there from, including, but not limited to, any costs or expenses (including attorneys' fees), incurred by Landlord in
(a) retaking possession of the Premises, (b) maintaining the Premises after Tenant's default, (c) preparing the Premises
for reletting to a new tenant, including any repairs or alterations, and (d) reletting the Premises, including brokers' commissions.



 


“The worth at the time of the award”
as used in subparagraphs (1) and (2) above is to be computed by allowing interest at the Interest Rate. “The worth at
the time of the award” as used in subparagraph (3) above is to be computed by discounting the amount at the discount rate of
the Federal Reserve Bank situated nearest to the Premises at the time of the award plus one percent (1%).


 


The waiver by Landlord of any breach of
any term, covenant or condition of this Lease shall not be deemed a waiver of such term, covenant or condition or of any subsequent breach
of the same or any other term, covenant or condition. Acceptance of Rent by Landlord subsequent to any breach hereof shall not be deemed
a waiver of any preceding breach other than the failure to pay the particular Rent so accepted, regardless of Landlord's knowledge of
any breach at the time of such acceptance of Rent. Landlord shall not be deemed to have waived any term, covenant or condition unless
Landlord gives Tenant written notice of such waiver.


 


		26.3	Landlord’s Default. In no event shall Landlord be deemed to be in default under this Lease
unless and until Landlord shall have defaulted in the performance of its obligations under this Lease and Tenant shall have given to Landlord
written notice of the default and, within a reasonable period of time following Landlord’s receipt of such notice, but in no event
less than thirty (30) days following Landlord’s receipt of such notice, Landlord shall not commence diligently to prosecute the
cure of such default to completion. Landlord hereby acknowledges that Tenant’s business requires continuous access to certain accommodations
to patrons that may be disabled or may require accommodations to their particular physical health considerations. In the event that Landlord
does not commence diligently to prosecute the cure of a default of Landlord’s obligations under this Lease, and which default substantially
impairs the access to, the Premises to completion within five (5) days after the thirty (30) day period following Landlord’s
receipt of such notice, Tenant shall have the right to cure such a default at its own expense and abate the Base Rent in the amount incurred
in the curing of such default. If Tenant does not elect to cure such default by Landlord pursuant to Section 26.3(a), and if Landlord
fails to cure the default of Landlord’s obligations under this Lease for a period of greater than sixty (60) days following the
receipt of notice of the default, Tenant shall have the option to terminate this Lease by submitting thirty (30) days’ written notice
to Landlord of such election to terminate. If, however, Landlord has diligently commenced the cure of the default in Landlord’s
obligations under this Lease, but has not been able to complete the cure of the default, Landlord shall have a reasonable time to complete
the cure of the default. As long as Landlord has diligently commenced and has continued to diligently prosecuted the cure of the default
of Landlord’s obligations under this Lease, Tenant shall not have the right to employ the cure of the default or to terminate this
Lease as provided in this Section 26.3. In the event of any alleged default on the part of Landlord under this Lease, Tenant shall
give notice by registered mail to any beneficiary or mortgagee of a deed of trust or mortgage encumbering the Premises whose address shall
have been furnished to Tenant, and shall offer such beneficiary or mortgagee a reasonable opportunity to cure the default, including time
to obtain possession of the Premises by power of sale or judicial foreclosure, if such shall be necessary to effect a cure. Tenant shall
not have the right to terminate this Lease or to withhold, reduce or offset any amount against any payments of Rent or any other amounts
due and payable under this Lease except as otherwise specifically provided herein. The liability of Landlord (including all persons and
entities that comprise Landlord) under this Lease or otherwise in the connection with the Premises or the Building shall be limited to
Landlord's interest in the Building, and in no event shall any other assets of Landlord or any assets of any constituent partner or member
of Landlord be subject to any liability arising out of or in connection with this Lease, the Premises or the Building on behalf of itself
and all persons claiming by, through, or under Tenant, Tenant expressly waives and releases Landlord from any personal liability for breach
of this Lease.



 






     


     


    

 


		27.	BROKERS.



 


Tenant represents and warrants that
Tenant has not dealt with any real estate broker, agent, finder or salesperson in connection with this Lease, except the real estate broker
listed in Article 1. Tenant shall indemnify, defend and hold Landlord harmless from and against any and all losses, costs, claims,
damages, liabilities and cause of action (including attorneys’ fees) arising out of or relating to any breach of the foregoing representation
warranty or arising out of or related to any claim made by any broker, agent, finder, or salesperson claiming to have dealt with Tenant.


 


		28.	NOTICES.



 


All notices and other communications
permitted or required to be given under this Lease shall be in writing and deemed duly served or given when sent via email, personally
delivered or transmitted by a private nationally recognized overnight courier service, or forty-eight (48) hours after deposit in the
United States mail, certified or registered, postage prepaid, and addressed as follows: (a) if to Landlord, to Landlord's Notice
Address and to the Building manager, and (b) if to Tenant, to Tenant's Notice Address; provided, however, notices to Tenant shall
be deemed duly served or given if delivered or mailed to Tenant at the Premises. Landlord and Tenant may from time to time by written
notice to the other party designate another address for receipt of future notices.


 






     


     


    

 


		29.	QUIET ENJOYMENT.



 


Tenant, upon paying the Rent and performing
all of its other obligations under this Lease, shall peaceably and quietly enjoy the Premises throughout the Term without any hindrance
or interruption by Landlord or any person lawfully claiming by, through or under Landlord, subject to the terms of this Lease and to any
mortgage, or deed of trust to which this Lease may be subordinate.


 


		30.	FORCE MAJEURE.



 


Any prevention, delay or stoppage of
work to be performed by Landlord or Tenant which is due to strikes, lockouts, other labor disputes, inability to obtain labor, materials,
equipment or reasonable substitutes therefore, acts of God, governmental restrictions or regulations or controls, judicial orders, enemy
or hostile government actions, civil commotion, fire or other casualty, or other causes beyond the reasonable control of the party obligated
to perform hereunder, shall excuse performance of the work by that party for a period equal to the duration of that prevention, delay
or stoppage. Notwithstanding the foregoing, in no event shall Tenant's obligation to pay Rent or other amounts payable under the Lease
be excused or delayed.


 


		31.	SIGN CONTROL.



 


Tenant shall not place or cause to be
placed, erected or maintained on any exterior door, wall, window or roof of the Premises or the Building, or on the glass of any window
or door of the Premises, or on any sidewalk or other location outside of the Premises, any sign, plaque, decoration, light, lettering
or other advertising material of any kind or description (collectively, “Signage”) without Landlord's prior written consent,
which shall not be unreasonably withheld. The size, content, design and/or location of any Signage shall be subject to Landlord’s
prior written approval, and shall comply with all applicable statutes, ordinances, rules and regulations of governmental authorities.
If Tenant shall place or cause to be placed or shall maintain any Signage in violation of the foregoing provisions then, without limiting
Landlord's other rights by reason thereof, Landlord shall have the right to cause the same to be removed without notice to Tenant and
without being liable to Tenant by reason of such removal. Landlord shall have the right to charge the cost of removal to Tenant as additional
rent hereunder, payable within ten (10) days of written demand by Landlord. Landlord shall have the right to place or cause to be
placed and to maintain on the exterior of the Building such Signage as Landlord shall desire.


 


		32.	MISCELLANEOUS.



 


		32.1	Accord and Satisfaction; Allocation of Payments. No payment by Tenant or receipt by Landlord of
a lesser amount than the Rent provided for in this Lease shall be deemed to be other than on account of the earliest due Rent. No endorsement
or statement on any check or letter accompanying any check or payment made on account of Rent shall be deemed an accord and satisfaction,
and Landlord may accept such check or payment without prejudice to Landlord's right to recover the balance of the Rent or pursue any other
remedy provided for in this Lease. In connection with the foregoing, Landlord shall have the absolute right in its sole discretion to
apply any payment received from Tenant to any amount owing by Tenant and then due and payable.



 






     


     


    

 


		32.2	Attorneys’ Fees. If any action or proceeding is brought by either party against the other
pertaining to or arising out of this Lease, the prevailing party in such action or proceeding shall be entitled to recover all costs and
expenses of such action or proceeding, including attorneys’ fees, and costs.



 


		32.3	Captions. The captions of Articles and Sections of this Lease have been inserted as a matter of
convenience and for reference only and in no way define, limit or enlarge the scope or meaning of this Lease. All references to Article and
Section numbers refer to Articles and Sections in this Lease.



 


		32.4	Governing Law. This Lease shall be governed by, and construed and enforced in accordance with,
the laws of the State of California.



 


		32.5	[Intentionally Omitted]



 


		32.5	Authority. If Tenant executes this Lease as a corporation, partnership or limited liability company,
each of the persons executing this Lease on behalf of Tenant does hereby covenant and warrant that Tenant is a duly authorized and existing
entity, that Tenant has full right and authority to enter into this Lease, and that each of the persons executing this Lease on behalf
of Tenant are authorized to do so. Upon Landlord’s request, Tenant shall provide Landlord with evidence reasonably satisfactory
to Landlord confirming the foregoing covenants and warranties.



 


		32.6	Counterparts. This Lease may be executed in multiple counterparts, each of which shall be deemed
to be an original, but all of which, taken together, shall constitute one and the same Lease.



 


		32.7	Execution of Lease; No Option. The submission of this Lease to Tenant shall be for examination
purposes only, and does not and shall not constitute a reservation of or option for Tenant to lease, or otherwise create any interest
of Tenant in the Premises or any other premises within the Building. The execution of this Lease by Tenant and its return to Landlord
shall not be binding on Landlord notwithstanding any time interval, until Landlord has in fact signed and delivered this Lease to Tenant.



 


		32.8	Financial Statements. Tenant shall promptly furnish Landlord, from time to time, upon Landlord’s
written request, with financial statements reflecting Tenant’s current financial condition. Tenant represents and warrants that
all financial statements, records and information furnished by Tenant to Landlord in connection with this Lease are true, correct and
complete in all respects.



 


		32.9	Further Assurances. Each party shall promptly execute all documents and take such other and further
acts as maybe reasonably requested by the other party in order to give effect to the provisions of this Lease.



 






     


     


    

 


		32.10	Prior Agreements; Amendments. This Lease contains all of the agreements of the parties with respect
to any matter covered in this Lease, and no prior agreement or understanding pertaining to any such matter shall be effective for any
purpose. This Lease may not be amended except by an agreement in writing signed by the parties hereto or their respective successors-in-interest.



 


		32.11	Recording. Tenant shall not record this Lease without the prior written consent of Landlord. Tenant,
upon the request of Landlord, shall execute and acknowledge a "short form" or memorandum of this Lease for recording purposes.
Landlord hereby consents to the recording of this Lease for Security and Exchange Commission requirements.



 


		32.12	Severability. If any provision of this Lease or the application thereof to any person or circumstance
shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such provision to persons or circumstances
other than those as to which it is invalid or unenforceable, shall not be affected thereby, and each provision of this Lease shall be
valid and enforceable to the fullest extent permitted by law.



 


		32.13	Successors and Assigns. Subject to the provisions of Article 16 of this Lease, this Lease
shall be binding upon, and shall inure to the benefit of, the heirs, personal representatives, successors and assigns of the parties hereto.



 


		32.14	Time of the Essence. Time is of the essence of this Lease and each and every provision hereof.



 


		32.15	Waiver. No delay or omission in the exercise of any right or remedy of Landlord upon any default
by Tenant shall impair such right or remedy or be construed as a waiver of such default. The receipt and acceptance by Landlord of delinquent
Rent shall not constitute a waiver of any other default; it shall constitute only a waiver of timely payment for the particular Rent payment
involved. Landlord's consent to or approval of any act by Tenant requiring Landlord's consent or approval shall not be deemed to waive
or render unnecessary Landlord's consent to or approval of any subsequent act by Tenant. Any waiver by Landlord of any default must be
in writing and shall not be a waiver of any other default concerning the same or any other provision of the Lease. Any waiver by Tenant
of any default must be in writing and shall not be a waiver of any other default concerning the same or any other provision of the Lease



 


		32.16	No Merger. A voluntary or other surrender of this Lease by Tenant, or a mutual cancellation thereof,
shall not work a merger, and shall, at the option of Landlord, either terminate any existing subleases or operate as an assignment to
Landlord of any such subleases.



 


		32.17	No Light, Air or View Easement. Nothing contained in this Lease shall grant to or confer upon Tenant
any right to receive any particular amount or level of light, air or view from the Premises. Any diminution in or shutting off of light,
air or view by any structure which is now or may hereafter be erected on property adjacent to the Building shall in no way affect this
Lease or impose any liability upon Landlord. Noise, dust or vibration or other aspects of the new construction of improvements on property
adjacent to the Building, whether or not owned by Landlord, shall in no way affect this Lease or impose any liability on Landlord.



 






     


     


    

 


		32.18	No Representations or Warranties. Neither Landlord nor Landlord’s officers, directors, shareholders,
members, partners, employees, agents or contractors have made any representations or warranties with respect to the Premises, the Building
or this Lease, except as expressly set forth herein.



 


		32.19	Name. Tenant shall not use the name of the Building for any purpose other than as an address of
the business to be conducted by Tenant in the Premises. Landlord shall have the right to change the name of the Building and/or the street
address of the Building from time to time in Landlord’s sole discretion.



 


		32.20	Exhibits, Addendum. The exhibits listed below and the addendum, if any, listed below, are incorporated
by reference into this Lease:



 


		(a)	Exhibit “A” -
Floor Plan of Premises



 


		(b)	Exhibit “B” -
Rules and Regulations



 


		(c)	Exhibit “C” –
Landlord’s Work



 


		(d)	Exhibit “D” -
DISABILITY ACCESS OBLIGATIONS NOTICE



 


		(e)	Exhibit “E” –
Right of First Offer



 






     


     


    

 





IN WITNESS WHEREOF, Landlord and Tenant have executed
this Lease as of the date first set forth above.


 


	LANDLORD	TENANT
	 	 
	M & E, LLC,	Jaguar Health, Inc.
	A California Limited Liability Company	A Delaware corporation



 


	By:	/s/
Elsie Sze

	 	By:	/s/ Lisa A. Conte
	 	 	 
	Its:	
Director
	 	Its:	President & CEO
	 	 	 
	Date:	April 6, 2021	 	Date:	April 1, 2021




 









     


     


    

 


EXHIBIT “A”


 


FLOOR PLAN OF PREMISES


 


Fourth (4th) Floor


 


 


 





 






     


     


    

 




EXHIBIT "B"


 


RULES AND REGULATIONS


 


Unless otherwise defined herein, capitalized terms
used in these Rules and Regulations have the meanings given to such terms in the Lease.


 


The sidewalks, halls, passages,
exits, vestibules, entrances, public areas, elevators and stairways of the Building shall not be obstructed by any of the Tenants or used
by them for any purpose other than ingress to and egress from their respective Premises. The halls, passages, exits, entrances, elevators
and stairways are not for the general public, and Landlord shall, in all cases, retain the right to control and prevent access thereto
by all persons whose presence in the judgment of Landlord would be prejudicial to the safety, character, reputation and interests of the
Building and its Tenants, provided that nothing herein contained shall be construed to prevent such access to persons with whom any Tenant
normally deals in the ordinary course of its business, unless such persons are engaged in illegal activities or activities which interfere
with the quiet enjoyment of other occupants of the Building. No Tenant and no employee or invitee of any Tenant shall go upon the roof
of the Building. If the Premises are situated on the ground floor with direct access to the street, then Tenant shall, at Tenant’s
expense, keep the sidewalks and curbs directly in front of the Premises clean and free from dirt, refuse and other obstructions.


 


No sign, placard, picture, name,
advertisement or notice visible from the exterior of any Tenant’s Premises shall be inscribed, painted, affixed or otherwise displayed
by any Tenant on any part of the Building without the prior written consent of Landlord. Landlord shall have the right to remove, at Tenant’s
expense and without notice or liability, any sign installed or displayed in violation of this rule. All approved signs or lettering on
doors, windows and walls shall be printed, painted, affixed or inscribed at the expense of the Tenant by a person or entity selected by
Landlord, using materials of Landlord’s choice and in a style and format approved by Landlord. Written material visible from outside
the Building will not be permitted. Landlord shall place Tenant’s name on the directory in the lobby of the Building and on the
individual floor directory, if available. Landlord reserves the right to restrict the amount of directory space utilized by Tenant. Tenant
shall not have the right to have additional names placed on the directory without Landlord’s prior written consent. If such consent
is given, the addition of such names shall be at Tenant’s expense.


 


The Premises shall not be used
for the storage of substantial amounts of merchandise held for sale to the general public, or for lodging or sleeping. No cooking shall
be done or permitted by any Tenant on the Premises, except the use by the Tenant of Underwriter’s Laboratory approved microwave
oven or equipment for brewing coffee, tea, hot chocolate and other similar beverages which shall be permitted, provided that the power
required by such equipment shall not exceed that amount which can be provided by a 30-amp circuit and that such use is in accordance with
all applicable federal, state and city laws, codes, ordinances, rules and regulations. Repair and maintenance of garbage disposals,
dishwashers, icemakers and other similar equipment shall be at Tenant’s expense. If the Premises or any part of the Building become
infested with vermin as a result of Tenant’s use, Tenant shall reimburse Landlord for the expense of extermination.


 






     


     


    

 


No Tenant shall employ any person
or persons other than the janitor of Landlord for the purpose of cleaning the Premises, unless otherwise agreed to by Landlord in writing.
Except with the written consent of Landlord, no person or persons other than those approved by Landlord shall be permitted to enter the
Building for the purpose of cleaning the same. No Tenant shall cause any unnecessary labor by reason of such Tenant’s carelessness
or indifference in the preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of or damage
to property on its Premises, however occurring.


 


Landlord will furnish each Tenant
with two keys to each door lock to its Premises and if reasonably required for access to the Premises, the Building, free of charge. Landlord
may make a reasonable charge for any additional keys. No Tenant shall have keys made except by Landlord’s designated locksmith.
No Tenant shall alter any lock or install a new or additional lock or bolts on any door of its Premises without the prior written consent
of Landlord. Tenant shall in each case furnish Landlord with a key for any such lock. Each Tenant, upon the termination of its tenancy,
shall deliver to Landlord all keys to doors in the Building which shall have been furnished to Tenant. In the event of the loss of any
key furnished to Tenant by Landlord, Tenant shall pay to Landlord the cost of replacing the same or of changing the lock or locks opened
by such lost key if Landlord shall deem it necessary to make such a charge.


 


The carrying in or out of freight,
furniture or bulky material of any description must take place during such hours as Landlord may from time to time reasonably determine,
which shall not include peak hours of elevator usage. Any damage caused by such activities shall be repaired by Landlord, at Tenant's
expense. The installation and moving of such freight, furniture or bulky material shall be made upon previous notice to the Building Manager
and the persons employed by the Tenant for such work must be reasonably acceptable to Landlord. Tenant may, subject to the provisions
of the immediately preceding sentence, move freight, furniture, bulky matter and other material into or out of the Premises after 6 p.m. and
before 7 a.m., Monday through Friday and on Saturdays after 1:00 p.m. and anytime on Sundays; provided Tenant pays the additional
costs, if any, incurred by Landlord for elevator operators, security guards and other expenses arising by reason of such move by Tenant.
If, at least two days prior to such move, Landlord requests the Tenant to deposit with Landlord, as security for Tenant’s obligation
to pay such additional costs, a sum which Landlord reasonably estimates to be the amount of such additional costs, then Tenant shall deposit
such sum with Landlord as security for such costs. Landlord shall have the right to prescribe the weight, size and position of all equipment,
materials, furniture or other property brought into the Building and placed in the Premises. Heavy objects, if considered necessary by
Landlord, shall stand on wood strips of such thickness as is necessary to properly distribute the weight. Landlord will not be responsible
for loss of or damage to any such property from any cause and all damage done to the Building by moving or maintaining such property shall
be repaired at the expense of Tenant. Business machines and other equipment shall be placed and maintained by Tenant at Tenant’s
expense in a setting sufficient, in Landlord’s reasonable judgment, to absorb and prevent unreasonable vibration and prevent noise
and annoyance.


 


No Tenant shall use or keep
in the Premises or the Building any kerosene, gasoline or flammable or combustible fluid or material other than limited quantities thereof
reasonably necessary for the operation or maintenance of office equipment; or without Landlord’s prior written approval, use any
extension cords, method of heating or air conditioning, including, without limitation, portable floor heaters and fans, other than that
supplied by Landlord. No Tenant shall use or keep or permit to be used or kept any hazardous or toxic materials or any foul or noxious
gas or substance in the Premises or permit or suffer the Premises or the Building to be occupied or used in a manner offensive or objectionable
to Landlord or other occupants of the Building by reason of noise, odors, vibrations, or interfere in any way with other tenants or those
having business therein.


 






     


     


    

 


Landlord shall have the right,
exercisable without notice and without liability to any tenant, to change the name and street address of the Building.


 


Any Tenant and its employees,
agents or associates or other persons entering or leaving the Building after ordinary business hours will be required to take reasonable
measures to assure that the front door of the Building is closed and latches. In the case of invasion, mob, riot, public excitement or
other circumstances rendering such action advisable in Landlord’s opinion, Landlord reserves the right to prevent access to the
Building during the continuance of the same by such action as Landlord may deem appropriate including closing doors. Landlord also reserves
the right to exclude or expel from the Building any person who, in Landlord’s judgment, is not in an area of the Building permitted
by such person, intoxicated or under the influence of liquor or drugs or who is in violation of any of the Rules and Regulations
of the Building.


 


No curtains, draperies, blinds,
shutters, shades, screens or other coverings hangings or decorations shall be attached to, hung or placed in, or used in connection with
any window of the Building without the prior written consent of Landlord. No files, cabinets, boxes, containers or similar items shall
be placed in, against or adjacent to any window of the Building so as to be visible from the outside of the Building. Tenant shall cooperate
fully with Landlord in obtaining maximum effectiveness of the cooling system of the Building by closing draperies and other window coverings
when the sun’s rays fall upon windows of the Premises. Tenant shall not obstruct, alter or in any way impair the efficient operation
of Landlord’s heating, ventilating, air conditioning, electrical, fire safety or lighting systems, nor shall Tenant tamper with
or change the setting of any thermostat or temperature control valves in the Building other than room thermostats installed for Tenant’s
use. Landlord reserves the right to install solar film on the windows of the Building to aid the efficiency of the HVAC system and to
reduce energy costs. Tenant shall not remove solar film from any window. Tenant shall also cooperate with Landlord to comply with any
governmental energy-saving rules, laws or regulations. No bottles, parcels or other articles may be placed in the halls or in any other
part of the Building, nor shall any article be thrown out of the doors or windows of the Premises.


 


Each Tenant shall make reasonable
efforts to secure its valuables, see that the doors of its Premises are closed and locked, that all water faucets, water apparatus, equipment,
lights and other utilities are shut off before Tenant or Tenant’s employees leave the Premises, so as to prevent waste or damage;
and for any default or carelessness in this regard, Tenant shall make good all injuries sustained by other tenants or occupants of the
Building or by Landlord. On multiple tenancy floors all Tenants shall keep the doors to the Building corridors closed at all times except
for ingress and egress.


 


The lavatory rooms, toilets,
urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they were constructed; no foreign
substance of any kind whatsoever shall be thrown therein and the expense of any breakage, stoppage or damage resulting from the violation
of this rule shall be borne by the Tenant who, or whose employees or invitees, shall have caused it. Landlord may require that all
or some of the toilet rooms be locked. In such event, a reasonable number of keys shall be provided to Tenant. Tenant shall pay for all
replacement keys and the cost of changing the lock or locks opened by such key if Landlord deems it necessary.


 


No Tenant shall install any
radio or television antenna, loudspeaker or other device on the roof or the exterior walls of the Building without the prior written consent
of Landlord. No awnings, air conditioning units or other projections shall be attached to the outside walls or windowsills of the Building
or otherwise project from the Building, without prior written consent of Landlord.


 






     


     


    

 


There shall not be used in
any space or public halls of the Building, either by any Tenant or any others, any hand trucks except those equipped with rubber tires
and side guards or such other material-handling equipment as Landlord may approve. No other vehicles of any kind except wheelchairs or
other similar devices shall be brought by any Tenant into the Building or kept in or about its Premises.


 


Each Tenant shall store all
its trash and garbage within its Premises. No material shall be placed in the trash boxes or receptacles if such material is of such nature
that it may not be disposed of in the ordinary and customary manner of removing and disposing of trash and garbage in the city where the
Building is located without being in violation of any law or ordinance governing such disposal. All garbage and refuse disposal shall
be made only through entry ways and elevators provided for such purposes and at such times as Landlord shall designate.


 


Each Tenant shall participate
in any recycling program for the Building, if any. Landlord shall provide information describing the Building’s recycling program
upon request. Tenant shall encourage participation in the recycling program by all employees. All recycling receptacles shall be retained
in each Tenant’s premises until pick-up by designated personnel at times and in the manner established by Landlord.


 


Canvassing, peddling, soliciting
and distribution of handbills or any other written materials in the Building are prohibited, and each Tenant shall cooperate to prevent
the same.


 


Tenant and its authorized
representative and invitees shall not make or permit any noise in the Building that is annoying, unpleasant or distasteful, interfering
in any way with other tenants or those having business with them, or bring into or keep within the Building or Common Areas any animal
(except for seeing eye dogs), bird, bicycle or other vehicle except wheelchairs or other similar devices, or such vehicles as are permitted
to park in the parking areas, if any, in accordance with the Rules and Regulations.


 


Tenant shall not mark, drive
nails, screw or drill into the partitions, woodwork or plaster or in any way deface the Premises or any part thereof, except to install
normal wall hangings. Tenant shall repair any damage resulting from non-compliance with this rule.


 


Landlord shall direct licensed
electricians as to where and how telephone and electrical wires are to be introduced. No cutting or boring for wires shall be allowed
without Landlord’s consent. The location of telephones, call boxes and office equipment affixed to the Premises shall be subject
to Landlord’s approval. Neither Tenant, its subtenants, assignees, agents, employees nor contractors shall have access to or make
any changes, alterations, additions, improvements, repairs or replacements (collectively, “work”) to the telephone closets,
telephone lines or any other communications facilities or equipment (collectively, the “telephone lines”) within the Building
without the prior written authorization of Landlord, which authorization may be withheld in Landlord’s sole discretion. All contractors
designated by Tenant to perform work on the telephone lines shall be licensed and shall be subject to Landlord’s prior written approval,
which approval may be withheld by Landlord in its sole discretion. Contractors performing work shall be required to provide evidence of
insurance coverage satisfactory to Landlord, including, without limitation, naming Landlord as an additional insured on all liability
policies. Any costs, expenses, and liabilities incurred by Landlord as a result of Tenant or Tenant’s contractor performing work
on the telephone lines shall be included in Tenant’s indemnification obligations under the Lease.


 






     


     


    

 


The requirements of the Tenant
will be attended to only upon appropriate application by an authorized individual to the office of the Building Manager by telephone,
facsimile or in person. Employees of Landlord shall not perform any work or do anything outside of their regular duties unless under special
instructions from Landlord.


 


Tenant shall comply with
all safety, fire protection and evacuation procedures and regulations established by Landlord or any governmental agency.


 


Tenant assumes any and all
responsibility for protecting its Premises from theft, robbery and pilferage, which includes keeping doors and other means of entry to
the Premises closed and locked when the Premises are unattended.


 


There shall be no smoking
in the Building, which areas include, without limitation, the Tenant’s premises, the lobby and the areas on individual floors in
the Building devoted to corridors, fire vestibules, elevators, foyers, lobbies, electric and telephone closets, restrooms, mechanical
and service rooms servicing the Building, janitor’s closets, and other similar facilities for the benefit of all tenants and invitees.
Tenant shall discourage its employees, agents, invitees and other person visiting Tenant from loitering outside the front of the Building
and/or disposing of smoking equipment. Smoking shall mean carrying or holding of a lighted pipe, cigar or cigarette of any kind, or any
other lighted smoking equipment or the lighting thereof or emitting or exhaling the smoke of a pipe, cigar or cigarette of any kind. Each
Tenant shall cooperate to enforce this prohibition, including giving notice of such to its employees.


 


Landlord may waive any one
or more of these Rules and Regulations for the benefit of any particular tenant or tenants, but no such waiver by Landlord shall
be construed as a waiver of such Rules and Regulations in favor of any other tenant or tenants, nor prevent Landlord from thereafter
enforcing any such rules and regulations against any or all of the tenants of the Building.


 


These Rules and Regulations
are in addition to, and shall not be construed to in any way modify or amend, in whole or in part, the terms, covenants, agreements and
conditions of any lease of Premises in the Building. To the extent that these Rules and Regulations are inconsistent with any provision
of the Lease, the provisions of the Lease shall control.


 


Landlord reserves the right
to make such other reasonable Rules and Regulations as, in its judgment, may from time to time be needed for the safety, care and
cleanliness of the Building, and for the preservation thereof.


 


Landlord shall not be responsible
to Tenant or to any other person for the non-observance or violation of these Rules and Regulations by any other tenant or other
person. Tenant shall be deemed to have read these rules and to have agreed to abide by them as a condition to its occupancy of the
space leased.


 









     


     


    

 


 


EXHIBIT “C”


 


LANDLORD’S WORK


 


Prior to the Commencement Date, Landlord shall
perform the following work at its sole cost and expense, to Suite 600:


 


		·	Repair or replace any damaged ceiling tiles and light fixtures as needed






		·	Replace 1 damaged door near the kitchen and conference






		·	New paint throughout Premises and elevator lobby to match 4th floor elevator lobby



 









     


     


    

 


Exhibit “D”


 


DISABILITY ACCESS OBLIGATIONS NOTICE


 


PURSUANT TO SAN FRANCISCO ADMINISTRATIVE CODE
CHAPTER 38.


 


Before you, as the Tenant,
enter into a lease with Landlord for the following property consisting of premises located at the building located at 200 Pine, San Francisco,
California ("Property"), please be aware of the following important information about the lease:


 


You May Be Held Liable
for Disability Access Violations on the Property. Even though you are not the owner of the Property, you, as the tenant, as well as
the Property owner, may still be subject to legal and financial liabilities if the leased Property does not comply with applicable Federal
and State disability access laws. You may wish to consult with an attorney prior to entering this agreement to make sure that you understand
your obligations under Federal and State disability access laws. The Landlord must provide you with a copy of the Small Business Commission
Access Information Notice under Section 38.6 of the San Francisco Administrative Code in your requested language. For more information
about disability access laws applicable to small businesses, you may wish to visit the website of the San Francisco Office of Small Business
or call 415-554-6134.


 


The Lease Must Specify
Who Is Responsible for Making Any Required Disability Access Improvements to the Property. Under the law for the City and County of
San Francisco, the lease must include a provision in which you, the Tenant, and the Landlord agree upon your respective obligations and
liabilities for making and paying for required disability access improvements on the leased Property. The lease must also require you
and the Landlord to use reasonable efforts to notify each other if they make alterations to the leased Property that might impact accessibility
under federal and state disability access laws. You may wish to review those provisions with your attorney prior to entering this agreement
to make sure that you understand your obligations under the lease.


 


PLEASE NOTE: The Property
may not currently meet all applicable construction-related accessibility standards, including standards for public restrooms and ground
floor entrances and exits.


 


By signing below I confirm
that I have read and understood this Disability Access Obligations Notice.


 


	LANDLORD	 
	 	M & E, LLC,
	 	A California Limited Liability Company
	 	 
	 	 



 


	Dated:	 	 	 	 
	 	 	 	By:	 
	 	 	 	 	 
	 	 	 	Its:	 



 


	TENANT	 	 
	 	 	Jaguar Health, Inc.
	 	 	A Delaware Corporation
	 	 	 
	Dated:	 	 	Lisa Conte



 


	 	By:	 
	 	 
	 	 
	 	Its: 	CEO


 






     


     


    

 


 


 



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EXHIBIT “E”


 


Right of First Offer


 


During the Lease Term only,
Tenant shall have the one (1) time right of first offer with respect to the fifth (5th) floor space in the Building (the
 “Offering Space”), which Right of First Offer shall be subject and subordinate to any right of first offer, first refusal,
expansion, extension of like or similar right existing as of the date of this Lease, and shall be exercised as follows: at any time after
Landlord has determined that the existing tenant in any portion of the Offering Space will not extend or renew the term of its lease
for the Offering Space (but prior to leasing such Offering Space to a party other than the existing tenant or a party holding a Superior
Right), Landlord shall advise Tenant (the “Advice”) of the terms under which Landlord is prepared to lease such portion of
the Offering Space to Tenant for the remainder of the Lease Term, including any extension (subject to the provisions set forth below).
Tenant may lease such portion of the Offering Space in its entirety only, under such terms, by delivering written notice of exercise
to Landlord (“Notice of Exercise”) within fifteen (15) business days after the date of the Advice. If Tenant fails or is
unable to timely exercise its right hereunder, then such right shall lapse, and Landlord may lease all or a portion of the Offering Space
to third parties on such terms as Landlord may elect (“Third Party Lease”); provided, however, if during the 180-day period
following the initial delivery of the Advice to Tenant, either (x) the rentable square footage of the Offering Space to be leased
changes by greater than ten percent (10%) or (y) the Economic Terms that Landlord is prepared to accept under a Third Party Lease
are greater than ten percent (10%) more favorable to the tenant than the Economic Terms offered by Landlord to Tenant (as such Economic
Terms are adjusted to account for the difference, if any, in the lease term offered to Tenant and the lease term offered to such third
party), then Landlord shall first make an offer of such more favorable Economic Terms (as such Economic Terms are adjusted to account
for the difference, if any, in the lease term offered to Tenant and the lease term offered to such third party) (the “New Offer
Terms”) to Tenant by written notice (the “Additional Notice”) setting forth the New Offer Terms, and Tenant shall have
five (5) business days from Tenant's receipt of the Additional Notice to accept the New Offer Terms set forth in the Additional
Notice (which procedure shall be repeated until Landlord enters into a lease or lease amendment with respect to such First Offer Space
which does not require Landlord to deliver another First Offer Notice to Tenant pursuant to the terms of this paragraph or Tenant exercises
such right of first offer, as applicable). As used in this Right of First Offer, "Economic Terms" shall refer to the net, aggregated
cost to Tenant or another party, on a present value basis, of the effect of the following terms for any particular Offering Space: (x) the
rental rate (including additional rent and considering any “base year” or “expense stop” applicable thereto);
(y) the amount of any improvement allowance or the value of any work to be performed by Landlord in connection with the lease of
such Offering Space (which amount is a deduction from the cost to Tenant or such other party); and (z) the amount of free rent (which
amount is a deduction from the cost to Tenant or such other party).


 






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No Right. Notwithstanding
the foregoing, Tenant shall have no such Right of First Offer and Landlord need not provide Tenant with an Advice, if:


 


(i) Tenant is in default
beyond notice and cure periods under the Lease at the time Landlord would otherwise deliver the Advice; or


 


(ii) more than the rentable
area equal to one (1) full floor of the Premises is sublet at the time Landlord would otherwise deliver the Advice other than assignments
or subleases pursuant to Section 13.7; or


 


(iii) the Lease has
been assigned in a transaction requiring Landlord's consent prior to the date Landlord would otherwise deliver the Advice other than assignments
or subleases pursuant to Section 13.7; or


 


(iv) the Offering Space
is not intended for the exclusive use of Tenant and its Permitted Users for the majority of the Lease Term; or


 


(v)  the existing tenant
in the Offering Space is interested in extending or renewing its lease for the Offering Space or entering into a new lease for such Offering
Space pursuant to a contractual right of the existing tenant to exercise an option to extend or renew.


 






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