FIG 2 SUPPL pollutant M A Label gene beta p valu e lower IC upper IC beta p valu e lower CI upper CI no2 interaction cratpos1p50 0.68 0.57 ‐ 1.67 3.04 0.89 0.50 ‐ 1.68 3.47 no2 lower than median cratpos1p50 ‐ 4.82 0.00 ‐ 7.36 ‐ 2.29 ‐ 5.58 0.00 ‐ 8.35 ‐ 2.81 no2 higher than median cratpos1p50 ‐ 4.14 0.00 ‐ 6.54 ‐ 1.74 ‐ 4.69 0.00 ‐ 7.31 ‐ 2.06 no2 interaction cratpos2p50 2.02 0.09 ‐ 0.31 4.35 1.88 0.15 ‐ 0.65 4.42 no2 lower than median cratpos2p50 ‐ 5.53 0.00 ‐ 8.11 ‐ 2.95 ‐ 6.16 0.00 ‐ 8.98 ‐ 3.34 no2 higher than median cratpos2p50 ‐ 3.52 0.00 ‐ 5.87 ‐ 1.17 ‐ 4.29 0.00 ‐ 6.85 ‐ 1.71 no2 interaction crat_meanp5 1.87 0.12 ‐ 0.47 4.21 1.81 0.16 ‐ 0.74 4.37 no2 lower than median crat_meanp5 ‐ 5.44 0.00 ‐ 7.99 ‐ 2.89 ‐ 6.02 0.00 ‐ 8.80 ‐ 3.23 no2 higher than median crat_meanp5 ‐ 3.58 0.00 ‐ 5.96 ‐ 1.19 ‐ 4.22 0.00 ‐ 6.81 ‐ 1.61 no2 interaction f3pos1p50 ‐ 0.46 0.72 ‐ 2.97 2.06 ‐ 0.87 0.54 ‐ 3.63 1.90 no2 lower than median f3pos1p50 ‐ 5.05 0.00 ‐ 7.82 ‐ 2.27 ‐ 5.73 0.00 ‐ 8.79 ‐ 2.66 no2 higher than median f3pos1p50 ‐ 5.50 0.00 ‐ 7.98 ‐ 3.03 ‐ 6.59 0.00 ‐ 9.32 ‐ 3.86 no2 interaction f3pos2p50 0.05 0.97 ‐ 2.52 2.63 ‐ 0.17 0.91 ‐ 3.00 2.68 no2 lower than median f3pos2p50 ‐ 5.58 0.00 ‐ 8.30 ‐ 2.85 ‐ 6.45 0.00 ‐ 9.46 ‐ 3.44 no2 higher than median f3pos2p50 ‐ 5.53 0.00 ‐ 8.06 ‐ 2.99 ‐ 6.62 0.00 ‐ 9.42 ‐ 3.81 no2 interaction f3pos3p50 0.53 0.69 ‐ 2.02 3.08 1.22 0.39 ‐ 1.60 4.05 no2 lower than median f3pos3p50 ‐ 5.46 0.00 ‐ 8.26 ‐ 2.66 ‐ 6.77 0.00 ‐ 9.87 ‐ 3.66 no2 higher than median f3pos3p50 ‐ 4.94 0.00 ‐ 7.43 ‐ 2.44 ‐ 5.55 0.00 ‐ 8.30 ‐ 2.79 no2 interaction f3pos4p50 0.38 0.77 ‐ 2.19 2.94 0.87 0.55 ‐ 1.97 3.71 no2 lower than median f3pos4p50 ‐ 5.55 0.00 ‐ 8.45 ‐ 2.64 ‐ 6.82 0.00 ‐ 10.03 ‐ 3.60 no2 higher than median f3pos4p50 ‐ 5.17 0.00 ‐ 7.59 ‐ 2.75 ‐ 5.95 0.00 ‐ 8.63 ‐ 3.27 no2 interaction f3pos5p50 ‐ 1.71 0.19 ‐ 4.26 0.84 ‐ 0.96 0.50 ‐ 3.79 1.87 no2 lower than median f3pos5p50 ‐ 4.16 0.00 ‐ 6.93 ‐ 1.39 ‐ 5.57 0.00 ‐ 8.65 ‐ 2.49 no2 higher than median f3pos5p50 ‐ 5.87 0.00 ‐ 8.35 ‐ 3.37 ‐ 6.53 0.00 ‐ 9.29 ‐ 3.76 no2 interaction f3_meanp50 0.25 0.85 ‐ 2.32 2.82 1.14 0.43 ‐ 1.70 3.99 no2 lower than median f3_meanp50 ‐ 5.38 0.00 ‐ 8.29 ‐ 2.45 ‐ 6.90 0.00 ‐ 10.13 ‐ 3.66 no2 higher than median f3_meanp50 ‐ 5.13 0.00 ‐ 7.54 ‐ 2.71 ‐ 5.76 0.00 ‐ 8.43 ‐ 3.09 no2 interaction gcrpos1p50 ‐ 0.15 0.90 ‐ 2.56 2.25 ‐ 0.79 0.54 ‐ 3.32 1.74 no2 lower than median gcrpos1p50 ‐ 4.07 0.00 ‐ 6.72 ‐ 1.42 ‐ 4.06 0.00 ‐ 6.86 ‐ 1.26 no2 higher than median gcrpos1p50 ‐ 4.23 0.00 ‐ 6.83 ‐ 1.62 ‐ 4.85 0.00 ‐ 7.61 ‐ 2.09 no2 interaction icampos1p50 ‐ 1.59 0.24 ‐ 4.21 1.04 ‐ 0.34 0.82 ‐ 3.26 2.60 no2 lower than median icampos1p50 ‐ 4.59 0.00 ‐ 7.31 ‐ 1.86 ‐ 5.71 0.00 ‐ 8.74 ‐ 2.67 no2 higher than median icampos1p50 ‐ 6.17 0.00 ‐ 8.87 ‐ 3.46 ‐ 6.04 0.00 ‐ 9.06 ‐ 3.02 no2 interaction icampos2p50 0.25 0.85 ‐ 2.40 2.90 1.11 0.46 ‐ 1.83 4.06 no2 lower than median icampos2p50 ‐ 5.56 0.00 ‐ 8.39 ‐ 2.73 ‐ 6.56 0.00 ‐ 9.70 ‐ 3.40 no2 higher than median icampos2p50 ‐ 5.31 0.00 ‐ 7.93 ‐ 2.69 ‐ 5.45 0.00 ‐ 8.36 ‐ 2.52 no2 interaction icampos3p50 0.49 0.71 ‐ 2.11 3.09 0.67 0.65 ‐ 2.22 3.56 no2 lower than median icampos3p50 ‐ 5.80 0.00 ‐ 8.44 ‐ 3.15 ‐ 6.39 0.00 ‐ 9.34 ‐ 3.44 no2 higher than median icampos3p50 ‐ 5.31 0.00 ‐ 8.08 ‐ 2.54 ‐ 5.73 0.00 ‐ 8.81 ‐ 2.63 no2 interaction icam_meanp5 0.03 0.99 ‐ 2.59 2.64 0.75 0.61 ‐ 2.16 3.67 no2 lower than median icam_meanp5 ‐ 5.50 0.00 ‐ 8.22 ‐ 2.78 ‐ 6.31 0.00 ‐ 9.34 ‐ 3.28 no2 higher than median icam_meanp5 ‐ 5.48 0.00 ‐ 8.18 ‐ 2.77 ‐ 5.57 0.00 ‐ 8.58 ‐ 2.55 no2 interaction ifnpos1p50 0.98 0.38 ‐ 1.23 3.18 1.54 0.21 ‐ 0.85 3.95 no2 lower than median ifnpos1p50 ‐ 5.04 0.00 ‐ 7.45 ‐ 2.62 ‐ 5.87 0.00 ‐ 8.50 ‐ 3.24 no2 higher than median ifnpos1p50 ‐ 4.06 0.00 ‐ 6.43 ‐ 1.69 ‐ 4.33 0.00 ‐ 6.91 ‐ 1.75 no2 interaction ifnpos2p50 0.06 0.96 ‐ 2.18 2.31 0.32 0.80 ‐ 2.13 2.77 no2 lower than median ifnpos2p50 ‐ 4.58 0.00 ‐ 7.03 ‐ 2.13 ‐ 5.23 0.00 ‐ 7.91 ‐ 2.55 no2 higher than median ifnpos2p50 ‐ 4.52 0.00 ‐ 6.86 ‐ 2.17 ‐ 4.91 0.00 ‐ 7.48 ‐ 2.35 no2 interaction ifn_meanp50 1.23 0.28 ‐ 1.02 3.48 1.25 0.31 ‐ 1.19 3.71 no2 lower than median ifn_meanp50 ‐ 5.13 0.00 ‐ 7.57 ‐ 2.70 ‐ 5.70 0.00 ‐ 8.36 ‐ 3.04 no2 higher than median ifn_meanp50 ‐ 3.91 0.00 ‐ 6.27 ‐ 1.55 ‐ 4.45 0.00 ‐ 7.03 ‐ 1.88 NO IPW fvc fev1



## analysis ‐ pgm1 ‐ AP ‐ LF ‐ interaction methylation9909 interactions 2013_04_30 ‐ for EPA.xlsx IntCurrMethylNoIpw 1 of 2no2 interaction il6pos1p50 0.58 0.60 ‐ 1.58 2.75 0.04 0.97 ‐ 2.29 2.36 no2 lower than median il6pos1p50 ‐ 4.85 0.00 ‐ 7.27 ‐ 2.43 ‐ 5.10 0.00 ‐ 7.71 ‐ 2.49 no2 higher than median il6pos1p50 ‐ 4.27 0.00 ‐ 6.59 ‐ 1.95 ‐ 5.06 0.00 ‐ 7.56 ‐ 2.56 no2 interaction il6pos2p50 ‐ 0.94 0.40 ‐ 3.12 1.24 ‐ 0.41 0.73 ‐ 2.75 1.94 no2 lower than median il6pos2p50 ‐ 4.02 0.00 ‐ 6.41 ‐ 1.63 ‐ 4.83 0.00 ‐ 7.40 ‐ 2.25 no2 higher than median il6pos2p50 ‐ 4.96 0.00 ‐ 7.32 ‐ 2.60 ‐ 5.24 0.00 ‐ 7.78 ‐ 2.69 no2 interaction il6_meanp50 ‐ 0.79 0.47 ‐ 2.93 1.35 ‐ 0.60 0.61 ‐ 2.90 1.71 no2 lower than median il6_meanp50 ‐ 4.16 0.00 ‐ 6.54 ‐ 1.77 ‐ 4.81 0.00 ‐ 7.39 ‐ 2.23 no2 higher than median il6_meanp50 ‐ 4.95 0.00 ‐ 7.28 ‐ 2.61 ‐ 5.41 0.00 ‐ 7.92 ‐ 2.88 no2 interaction inospos1p50 ‐ 1.03 0.45 ‐ 3.72 1.66 0.19 0.90 ‐ 2.83 3.22 no2 lower than median inospos1p50 ‐ 4.54 0.00 ‐ 7.62 ‐ 1.46 ‐ 5.18 0.00 ‐ 8.64 ‐ 1.71 no2 higher than median inospos1p50 ‐ 5.57 0.00 ‐ 8.52 ‐ 2.61 ‐ 4.99 0.00 ‐ 8.31 ‐ 1.66 no2 interaction inospos2p50 ‐ 0.96 0.52 ‐ 3.88 1.97 ‐ 1.41 0.40 ‐ 4.68 1.86 no2 lower than median inospos2p50 ‐ 4.78 0.00 ‐ 7.81 ‐ 1.74 ‐ 4.45 0.01 ‐ 7.85 ‐ 1.05 no2 higher than median inospos2p50 ‐ 5.73 0.00 ‐ 8.86 ‐ 2.60 ‐ 5.86 0.00 ‐ 9.36 ‐ 2.35 no2 interaction inos_meanp5 ‐ 0.78 0.59 ‐ 3.59 2.05 ‐ 0.42 0.79 ‐ 3.59 2.75 no2 lower than median inos_meanp5 ‐ 4.83 0.00 ‐ 7.89 ‐ 1.76 ‐ 4.99 0.00 ‐ 8.43 ‐ 1.54 no2 higher than median inos_meanp5 ‐ 5.60 0.00 ‐ 8.63 ‐ 2.56 ‐ 5.41 0.00 ‐ 8.82 ‐ 2.00 no2 interaction oggpos1p50 ‐ 1.72 0.27 ‐ 4.75 1.32 ‐ 1.60 0.37 ‐ 5.07 1.89 no2 lower than median oggpos1p50 ‐ 3.61 0.03 ‐ 6.83 ‐ 0.38 ‐ 3.83 0.04 ‐ 7.52 ‐ 0.13 no2 higher than median oggpos1p50 ‐ 5.33 0.00 ‐ 8.43 ‐ 2.22 ‐ 5.42 0.00 ‐ 8.97 ‐ 1.86 no2 interaction oggpos2p50 ‐ 0.75 0.64 ‐ 3.88 2.37 ‐ 0.65 0.72 ‐ 4.24 2.95 no2 lower than median oggpos2p50 ‐ 3.90 0.02 ‐ 7.07 ‐ 0.71 ‐ 4.22 0.02 ‐ 7.86 ‐ 0.57 no2 higher than median oggpos2p50 ‐ 4.65 0.01 ‐ 7.94 ‐ 1.35 ‐ 4.87 0.01 ‐ 8.64 ‐ 1.09 no2 interaction oggpos3p50 0.14 0.93 ‐ 2.75 3.03 0.50 0.77 ‐ 2.82 3.84 no2 lower than median oggpos3p50 ‐ 4.54 0.00 ‐ 7.69 ‐ 1.38 ‐ 4.94 0.01 ‐ 8.55 ‐ 1.33 no2 higher than median oggpos3p50 ‐ 4.40 0.01 ‐ 7.52 ‐ 1.28 ‐ 4.44 0.02 ‐ 8.02 ‐ 0.86 no2 interaction oggpos4p50 ‐ 1.73 0.23 ‐ 4.57 1.11 ‐ 2.08 0.21 ‐ 5.34 1.19 no2 lower than median oggpos4p50 ‐ 3.56 0.03 ‐ 6.72 ‐ 0.39 ‐ 3.57 0.05 ‐ 7.20 0.07 no2 higher than median oggpos4p50 ‐ 5.28 0.00 ‐ 8.35 ‐ 2.22 ‐ 5.64 0.00 ‐ 9.15 ‐ 2.12 no2 interaction ogg_meanp50 ‐ 2.28 0.14 ‐ 5.32 0.76 ‐ 1.86 0.30 ‐ 5.35 1.65 no2 lower than median ogg_meanp50 ‐ 3.43 0.03 ‐ 6.56 ‐ 0.28 ‐ 3.89 0.03 ‐ 7.49 ‐ 0.28 no2 higher than median ogg_meanp50 ‐ 5.70 0.00 ‐ 8.93 ‐ 2.46 ‐ 5.74 0.00 ‐ 9.45 ‐ 2.03 no2 interaction tlr2pos1p50 ‐ 0.11 0.93 ‐ 2.64 2.42 0.27 0.85 ‐ 2.51 3.05 no2 lower than median tlr2pos1p50 ‐ 4.43 0.00 ‐ 7.18 ‐ 1.69 ‐ 5.37 0.00 ‐ 8.39 ‐ 2.34 no2 higher than median tlr2pos1p50 ‐ 4.55 0.00 ‐ 7.10 ‐ 1.99 ‐ 5.10 0.00 ‐ 7.91 ‐ 2.29 no2 interaction tlr2pos2p50 0.25 0.85 ‐ 2.29 2.80 0.44 0.76 ‐ 2.36 3.24 no2 lower than median tlr2pos2p50 ‐ 4.57 0.00 ‐ 7.26 ‐ 1.87 ‐ 5.37 0.00 ‐ 8.33 ‐ 2.41 no2 higher than median tlr2pos2p50 ‐ 4.31 0.00 ‐ 6.91 ‐ 1.72 ‐ 4.93 0.00 ‐ 7.78 ‐ 2.08 no2 interaction tlr2pos3p50 ‐ 1.15 0.38 ‐ 3.72 1.42 ‐ 1.30 0.37 ‐ 4.12 1.53 no2 lower than median tlr2pos3p50 ‐ 3.87 0.01 ‐ 6.57 ‐ 1.16 ‐ 4.51 0.00 ‐ 7.48 ‐ 1.53 no2 higher than median tlr2pos3p50 ‐ 5.01 0.00 ‐ 7.61 ‐ 2.42 ‐ 5.80 0.00 ‐ 8.66 ‐ 2.94 no2 interaction tlr2pos4p50 1.18 0.37 ‐ 1.40 3.76 2.75 0.06 ‐ 0.09 5.59 no2 lower than median tlr2pos4p50 ‐ 5.01 0.00 ‐ 7.69 ‐ 2.33 ‐ 6.55 0.00 ‐ 9.49 ‐ 3.59 no2 higher than median tlr2pos4p50 ‐ 3.84 0.00 ‐ 6.45 ‐ 1.22 ‐ 3.81 0.01 ‐ 6.68 ‐ 0.93 no2 interaction tlr2pos5p50 ‐ 2.14 0.10 ‐ 4.70 0.43 ‐ 3.25 0.02 ‐ 6.05 ‐ 0.43 no2 lower than median tlr2pos5p50 ‐ 3.47 0.01 ‐ 6.07 ‐ 0.87 ‐ 3.71 0.01 ‐ 6.56 ‐ 0.85 no2 higher than median tlr2pos5p50 ‐ 5.60 0.00 ‐ 8.29 ‐ 2.90 ‐ 6.94 0.00 ‐ 9.91 ‐ 3.98 no2 interaction tlr2_meanp5 1.44 0.28 ‐ 1.20 4.09 1.16 0.43 ‐ 1.75 4.08 no2 lower than median tlr2_meanp5 ‐ 5.29 0.00 ‐ 8.03 ‐ 2.56 ‐ 5.86 0.00 ‐ 8.88 ‐ 2.84 no2 higher than median tlr2_meanp5 ‐ 3.86 0.00 ‐ 6.45 ‐ 1.26 ‐ 4.71 0.00 ‐ 7.56 ‐ 1.84 

## analysis ‐ pgm1 ‐ AP ‐ LF ‐ interaction methylation9909 interactions 2013_04_30 ‐ for EPA.xlsx IntCurrMethylNoIpw 2 of 2