# Support Documents for Significant New Use Rule (SNUR) on Premanufacture Notice (PMN)
P-09-373

EPA Docket EPA-HQ-OPPT-2010-1075

# Index
A-001 Structure Activity Team (SAT) Report for PMN P-09-373
A-002 Initial Review Engineering Report for PMN P-09-373
A-003 Initial Review Exposure Report for PMN P-09-373

# A-001 Structure Activity Team (SAT) Report
for PMN P-09-373

## SAT Report PMN Number: P-09-0373 SAT Date: 5/29/2009

Related cases : Health related cases: Ecotox related cases:

Concern levels : 

### Type of Concern: Health Eco Comments Level of Concern: 1-2 2

Persistence Bioaccum Toxicity Comments 1 1 1 Anion 3 1 2 Mn
Exposure Based Review : Health: Ecotox: N o
Routes of exposure : Health: Inhalation, drinking water Ecotox: All releases to water Fate: ; Anion negl; Cation slow
Keywords : Keywords: THYROID; KIDNEY; BLOOD; LIVER; IRR; N EURO; UNCERT-IMMUNO; MUTA; UNCERT-ONCO; AQUATOX
Summary of Assessment :

Fate : Fate Summary: P-09-0373 FATE: Solid S > 10 g/L at 25 EC (ICB) VP < 1.0E-6 torr at 25 EC (E) BP > 400 EC (E) H < 1.00E-8 (E) POTW removal (%) = Anion 90-99 via biodeg; Cation 35.5 via sorption Time for complete ultimate aerobic biodeg = U Sorption to soils/sediments = Anion low; Cation moderate PBT Potential: Anion P1B1; Mn: P3B1

### *CEB FATE: Migration to ground water = Anion negl; Cation slow

Health : Health Summary: N ot absorbed from the skin, absorbed from the lung ( p che m ), absorbed from the GI tract (analog). There are multiple studies available for the sulfate material (mostly the monohydrate) from NTP and a TSCA Section 8e submission. This chemical is considered to be a better analog than the variety of salts of thiosulfate included in the PMN submission. In a 90-day inhalation study in rats signs of nasal irritation were noted at 1.53 mg Mn/m3 with a NOEL of 0.31 mg Mn/m3. Red blood cell depression was seen in a 13-week dietary study in rats at 6,250 p pm and greater in the diet with a NOEL of 3,130 p p m ( N TP T R -428). A lesser degree of toxicity was noted in the 13-week dietary study in mice with a NOEL of 12,500 p pm and lower leukocyte counts at 25,000 p pm and greate r . Manganese (II) sulfate monohydrate was not mutagenic in Salmonella typhimurium with and without activation and did not induce sex-linked recessive lethal mutations in germ cells of Drosophila. The analog was positive for sister chromatid exchange and chromosomal aberrations in Chinese hamster ovary cells. Mn sulfate is positive in yeast and other Mn compounds are positive for mutagenicity. There is uncertain concern for oncogenicity by analogy to Mn (II) sulfate monohydrate which showed no evidence of carcinogenic activity in male and female rats at doses up to 15,000 p pm in the diet and equivocal evidence in male and female mice based on marginally increased incidence of thyroid gland follicular cell adenoma and a significant increase in follicular cell hyperplasia. There was decreased survival in males at the top dose (15,000 p p m ) caused predominantly by advanced renal disease. Potential liver effects were also noted. Additional concerns for Mn are neurotoxicity and possible immunotoxicity

. Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 9.4 daphnid 48-h LC50 64 green algal 96-h EC50 <60 fish

_ chronic value 4.0 daphnid

_ chronic value 12 algal

_ chronic value <15 Sewage Sludge 3-h EC50

_ Sewage Sludge Chronic Value

Ecotox Values Comments: Predictions are based on SAR-nearest analog analysis for soluble salts of Mn with MW adjustment; SAR chemical class = Mn.thiosulfuric acid ; MW167 with 33wt% Mn (MW55); solid with mp unknown (P); S > 180 g/L at 20 C, p H 7 (P); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations of total Mn; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10

### Concentration of Concern ( p pb) 400

SARs Mn salts SAR Class Mn salt

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916

# A-002 Initial Review Engineering Report
for PMN P-09-373

### INITIAL REVIEW ENGINEERING REPORT P-09-0373 Focus Ready Draft 6/4/2009

ENGINEER: Prothero \ AH PV (kg/yr):

Revision Notes/Assessment Overview:

SUBMITTER: Tessenderlo Kerley, Inc. (submitter)

USE: Micronutrient manganese source for selected agricultural crops.

OTHER USES:

MSDS : Yes LABEL : Yes
Gen Eqpt: N eoprene rubber gloves and apron. Chemical goggles and full face shield. Adequate exhaust ventilation to prevent inhalation of product vapors. Respirator: N one generally required. If conditions exist where mist may be generated, a NIOSH/MSHA approved mist respirator should be worn. Health Effects: Contact may cause eye irritation. Repeated/prolonged skin contact may cause irritation. Ingestion may irritate gastrointestinal tract. Heating may cause sulfur dioxide gas to evolve. TLV/PEL : - none established

CRSS: (12:00:00 AM): Chemical Name: Thiosulfuric acid (H2S2O3), manganese(2+) salt (1:1) S-H2O: 180 g/L @ VP: 1.0E-6 torr @ MW: 167 0.0%<500 0.0%<1000 Physical State and Misc CRSS Info: Neat: Solid Mfg: Solution: 18% PMN substance in water Proc/Form: Solution: 6% PMN substance in water End Use: Solid: deposited in soil. Submitted data: The MSDS and Physical/Chemicals Property Worksheet are for the 18% solution of the PMN substance in water. Pale pink liquid; density (18% solution in water) = 1.19 g/L; pH (18% solution in water) = 5.68. Estimated Data: VP <0.000001 torr (Salt); S-H2O > 180 g/L (Concentration of manufactured substance).

Consumer Use: N o
SAT (concerns): (5/29/2009):
Migration to groundwater: Anion negligible; Cation slow PBT rating: P 3 B 1 T 2 PBT Potential: Anion P1B1T1; Mn P3B1T2 Health: 1-2, Drinking Water, Inhalation Eco: 2, Water (All releases to water with a CC = 400 ppb)

OCCUPATIONAL EXPOSURE RATING: 2C

NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.POLLUTION PREVENTION CONSIDERATIONS: N one

P2 REC:

EXPOSURE-BASED REVIEW: N o (0 criteria met)P-09-0373

Use:

Number of Sites/Location: 1

Basis: Process Description:



## ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

Water or Landfill High End: 6.0E-2 kg/site-day over 10 day/yr from 20 sites or 1.2E+1 kg/y r to: uncertain from: basis:

Water or Landfill Output 2: 9.5E+0 kg/site-day over 10 day/yr from 20 sites or 1.9E+3 kg/y r to: from: basis:



## RELEASE TOTAL 1.9E+3 kg/y r - all sites



## OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 60 Basis:

.

Inhalation:

Exposure to Mist Upper Bound: 9.0E+0 mg /day over 10 days/y r Number of workers (all sites) with Inhalation exposure: 60 Basis:

## INHALATION MONITORING DATA REVIEW 1) Uncertainty (estimate based on model, regulatory limit, or data not specific to industry): Yes 2) (a) Exposure level > 1 mg/day? Yes (b) Hazard Rating for health of 2 or greater? N o Inhalation Monitoring Data Desired? N o

Dermal:
Exposure to Liquid High End: 3.2E+2 mg/day over 10 days/y r Number of workers (all sites) with Dermal exposure: 60 Basis:P-09-0373

Manufacturing

Number of Sites/Location: 1

Basis:

Process Description:



## ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

Water or Landfill Conservative: 4.4E+0 kg/site-day over 9 day/yr from 1 sites or 4.0E+1 kg/y r to: uncertain from: basis:



## RELEASE TOTAL 4.0E+1 kg/y r - all sites



## OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 3 Basis:

Dermal:
Exposure to Liquid High End: 3.2E+2 mg/day over 9 days/y r Number of workers (all sites) with Dermal exposure: 3 Basis:P-09-0373

Distribution

Number of Sites/Location: 1

Basis: Process Description:



## ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

Water or Landfill Conservative: 1.3E+0 kg/site-day over 10 day/yr from 3 sites or 4.0E+1 kg/y r to: uncertain from: basis:



## RELEASE TOTAL 4.0E+1 kg/y r - all sites



## OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 9 Basis:

Dermal:
Exposure to Liquid High End: 3.2E+2 mg/day over 10 days/y r Number of workers (all sites) with Dermal exposure: 9 Basis:INITIAL REVIEW ENGINEERING REPORT PMN: 09-0373 Standard Review Draft 7/7/2009

ENGINEER: Prothero \ AH PV (kg/yr):

SUBMITTER: Tessenderlo Kerley, Inc.
USE: Micronutrient manganese source for selected agricultural crops.

OTHER USES:

MSDS: Yes Label: Yes
Gen Eqpt: Neoprene rubber gloves and apron. Chemical goggles and full face shield. Adequate exhaust ventilation to prevent inhalation of product vapors. Respirator: None generally required. If conditions exist where mist may be generated, a NIOSH/MSHA approved mist respirator should be worn. Health Effects: Contact may cause eye irritation. Repeated/prolonged skin contact may cause irritation. Ingestion may irritate gastrointestinal tract. Heating may cause sulfur dioxide gas to evolve. TLV/PEL: none established

CRSS : Chemical Name: Thiosulfuric acid (H2S2O3), manganese(2+) salt (1: 1) S-H20: 180 g/L @ VP: 1.0E-6 torr @ MW: 167.00 %<500 %<1000 Physical State and Misc CRSS Info: Neat: Solid Mfg: Solution: 18% PMN substance in water Proc/Form: Solution: 6% PMN substance in water End Use: Solid: deposited in soil. Submitted data: The MSDS and Physical/Chemicals Property Worksheet are for the 18% solution of the PMN substance in water. Pale pink liquid; density (18% solution in water) = 1.19 g/L; pH (18% solution in water) = 5.68. Estimated Data: VP <0.000001 torr (Salt); S-H2O > 180 g/L (Concentration of manufactured substance).

Consumer Use: No
SAT (concerns) (05/29/2009): Related Cases and Related Cases and Misc SAT Info:Migration to groundwater: Anion negligible; Cation slow PBT rating: P3B1T2 PBT Potential: Anion P1B1T1; Mn P3B1T2 Health: 1-2 Drinking Water, Inhalation Eco: 2 Water (All releases to water with a CC = 400 ppb)

OCCUPATIONAL EXPOSURE RATING: 2B

NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS: None

EXPOSURE-BASED REVIEW: NoINITIAL REVIEW ENGINEERING REPORT PMN: 09-0373
Manufacturing

Number of Sites/ Location: 1

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 0 Basis:

Inhalation:

Dermal:INITIAL REVIEW ENGINEERING REPORT PMN: 09-0373

Number of Sites/ Location: 3

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 0 Basis:

Inhalation:

Dermal:INITIAL REVIEW ENGINEERING REPORT PMN: 09-0373

Use:

Number of Sites/ Location: 20

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 20 Basis:

Inhalation:

Exposure to Mist (non-volatile) (Class I) What-If: 2.8E+0 mg/day over 10 days/yr Number of workers (all sites) with inhalation exposure: 20 Basis:NOTE: The respirator class is: I. Particulate (including solid or liquid droplets).

INHALATION MONITORING DATA REVIEW 1) Uncertainty (estimate based on model, regulatory limit, or data not specific to industry): Yes 2)a) Exposure level > 1 mg/day? Yes OR b) Hazard Rating for health of 2 or greater? 1-2 No Inhalation Monitoring Data Desired? Yes (both criteria met)

Dermal:

# A-003 Initial Review Exposure Report
for PMN P-09-3736/3/2009 Page of

INITIAL REVIEW EXPOSU RE REPORT (IRExR)

Chemical ID: P090373 Reviewer: Kwon
Results Table: Dose, Concentration, and Days Exceeded Results Summary

Exposure Scenario 1 Water Landfill Stack Air Fugitive Air Drinking Water Fish Ingestion
ADR LADD ADR LADD 7Q10 4 CC=400 PDM Days Exceeded LADD ADR LADD ADR LADD Release activity(ies) 2 ; exposure calculation(s) 3 mg/kg/day mg/kg/day mg/kg/day mg/kg/day μ g/l # Days mg/kg/day mg/kg/day mg/kg/day mg/kg/day mg/kg/day 

### ANION max ADR, max Acute Eco, max LADD 2 .63E-03 1.12E-0 6 --- --- 54.53 --- --- --- --- --- ---

max ADR, max Acute Eco, max LADD 5 .47E-04 4.69E-0 7 --- --- 11.21 --- --- --- --- --- --- max ADR, max Acute Eco, max LADD 2 .76E-02 1.23E-0 5 --- --- 604.72 --- --- --- --- --- --- 

### CATION max ADR, max Acute Eco, max LADD 8 .33E-03 3.56E-0 6 --- --- 172.87 --- --- --- --- --- ---

max ADR, max Acute Eco, max LADD 1 .74E-03 1.50E-0 6 --- --- 35.74 --- --- --- --- --- --- max ADR, max Acute Eco, max LADD 8 .75E-02 3.91E-0 5 --- --- 1916.75 --- 6.55E-05 --- --- --- ---

1 Exposure scenario titles consist of release activ ity followed by exposure calculation abbreviation. 2 Release activities are from engineering report's Manufactur ing (Mfg), Processing (Proc) and Use release activity labels. Multiple release activities are combined in one exposure scenario if their releases occur at same location. 3 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and Probabilistic Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure scenario. CC is the aquatic concentration of concern. 4 This column displays concentration values for the 7Q10 streamflow, which is defined as the average streamflow of the 7 consecutive days of lowest flow within a 10 year period.

Remarks:

Fate test recommendations?:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373anion Assessor: Kwon

ENVIRONMENTAL RELEASES

Scenario#:1 Number of Release Sites: Release Activity: max ADR, max Acute Eco, max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:

Per Site Release: (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373anion

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 1 Number of Site s: RELEASE ACTIVITY max ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: SIC-CODE (S): EXPOSED POPULATION: Adult

WWT REMOVAL (%) RELEASE DAYS PRETREATMENT RELEASE (kg/site/day) POSTTREATMENT RELEASE (kg/site/day) DWT (%) BCF (L/kg)
0.00 0.00

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic Mean 30Q5 7Q10 1Q10

ALL 50 0.10 0.32 0.47 0.57

ALL 10 5.83 31.45 54.53 65.12

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units 50% 10% 50% 10%

Cancer

LADD pot 2.01E-08 1.12E-06 mg/kg/day 0.00 0.00 mg/kg/day

LADC pot 1.03E-06 5.75E-05 mg/L 0.00 0.00 mg/kg

Acute

ADR pot 2.64E-05 2.63E-03 mg/kg/day 0.00 0.00 mg/kg/day

SIC Code Comments:6/3/2009 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090373anion Assessor:

ENVIRONMENTAL RELEASES

Scenario#:2 Number of Release Sites Release Activity: ma x ADr, max Acute Eco, max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:

Per Site Release: (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373anion

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 2 Number of S ites: RELEASE ACTIVITY max ADr, max Acute Eco, max LADD SIC-CODE DESCRIPTION: POTW (Indust., incl udes POTWs which receive ind. disch.) SIC-CODE (S): 4952 EX POSED POPULATION: Adult

WWT REMOVAL (%) RELEASE DAYS PRETREATMENT RELEASE (kg/site/day) POSTTREATMENT RELEASE (kg/site/day) DWT (%) BCF (L/kg)
0.00 0.00

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic Mean 30Q5 7Q10 1Q10

ALL 50 288.00 123.84 78.18 66.05 0.30 0.70 1.11 1.32

ALL 10 39.60 13.29 7.76 7.57 2.20 6.55 11.21 11.49

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units 50% 10% 50% 10%

Cancer

LADD pot 6.46E-08 4.69E-07 mg/kg/day 0.00 0.00 mg/kg/day

LADC pot 3.31E-06 2.41E-05 mg/L 0.00 0.00 mg/kg

Acute

ADR pot 5.87E-05 5.47E-04 mg/kg/day 0.00 0.00 mg/kg/day

SIC Code Comments:6/3/2009 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090373anion Assessor:

ENVIRONMENTAL RELEASES

Scenario#:3 Number of Release Sites: Release Activity: : max ADR, max Acute Eco, max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:

Per Site Release: (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373anion

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 3 Number of Sites RELEASE ACTIVITY max ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: POTW's (All facilities) SIC-CODE (S): 4952 EX POSED POPULATION: Adult

WWT REMOVAL (%) RELEASE DAYS PRETREATMENT RELEASE (kg/site/day) POSTTREATMENT RELEASE (kg/site/day) DWT (%) BCF (L/kg)
0.00 0.00

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic Mean 30Q5 7Q10 1Q10

ALL 50 125.56 44.02 26.80 22.53 5.11 14.56 23.92 28.45

ALL 10 11.11 1.94 1.06 0.96 57.70 330.41 604.72 667.71

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units 50% 10% 50% 10%

Cancer

LADD pot 1.09E-06 1.23E-05 mg/kg/day 0.00 0.00 mg/kg/day

LADC pot 5.59E-05 6.32E-04 mg/L 0.00 0.00 mg/kg

Acute

ADR pot 1.22E-03 2.76E-02 mg/kg/day 0.00 0.00 mg/kg/day

SIC Code Comments:6/3/2009 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090373cation Assessor: Kwon

ENVIRONMENTAL RELEASES

Scenario#:1 Number of Release Sites: Release Activity: max ADR, max Acute Eco, max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:

Per Site Release: (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373cation

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 1 Number of Site s RELEASE ACTIVITY max ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: SIC-CODE (S) EXPOSED POPULATION: Adult

WWT REMOVAL (%) RELEASE DAYS PRETREATMENT RELEASE (kg/site/day) POSTTREATMENT RELEASE (kg/site/day) DWT (%) BCF (L/kg)
0.00 0.00

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic Mean 30Q5 7Q10 1Q10

ALL 50 0.33 1.00 1.47 1.82

ALL 10 18.49 99.71 172.87 206.46

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units 50% 10% 50% 10%

Cancer

LADD pot 6.37E-08 3.56E-06 mg/kg/day 0.00 0.00 mg/kg/day

LADC pot 3.26E-06 1.82E-04 mg/L 0.00 0.00 mg/kg

Acute

ADR pot 8.35E-05 8.33E-03 mg/kg/day 0.00 0.00 mg/kg/day

SIC Code Comments:6/3/2009 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090373cation Assessor:

ENVIRONMENTAL RELEASES

Scenario#:2 Number of Release Sites: Release Activity: max ADR, max Acute Eco, max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:

Per Site Release: (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373cation

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 2 Number of S ites: RELEASE ACTIVITY max ADR, max Acute Eco, max LADD SIC-CODE DESCRIPTION: POTW (Indust., incl udes POTWs which receive ind. disch.) SIC-CODE (S): 4952 EX POSED POPULATION: Adult

WWT REMOVAL (%) RELEASE DAYS PRETREATMENT RELEASE (kg/site/day) POSTTREATMENT RELEASE (kg/site/day) DWT (%) BCF (L/kg)
0.00 0.00

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic Mean 30Q5 7Q10 1Q10

ALL 50 288.00 123.84 78.18 66.05 0.96 2.24 3.55 4.20

ALL 10 39.60 13.29 7.76 7.57 7.00 20.87 35.74 36.64

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units 50% 10% 50% 10%

Cancer

LADD pot 2.06E-07 1.50E-06 mg/kg/day 0.00 0.00 mg/kg/day

LADC pot 1.06E-05 7.68E-05 mg/L 0.00 0.00 mg/kg

Acute

ADR pot 1.87E-04 1.74E-03 mg/kg/day 0.00 0.00 mg/kg/day

SIC Code Comments:6/3/2009 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090373cation Assessor:

ENVIRONMENTAL RELEASES

Scenario#:3 Number of Release Sites: Release Activity: max ADR, max Acute Eco, max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:

Per Site Release: (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:6/3/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090373cation

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 3 Number of Sites RELEASE ACTIVITY max ADR, max Acute Eco, max LADD

SIC-CODE DESCRIPTION: POTW's (All facilities) SIC-CODE (S): 4952 EX POSED POPULATION: Adult

WWT REMOVAL (%) RELEASE DAYS PRETREATMENT RELEASE (kg/site/day) POSTTREATMENT RELEASE (kg/site/day) DWT (%) BCF (L/kg)

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic Mean 30Q5 7Q10 1Q10

ALL 50 125.56 44.02 26.80 22.53 16.18 46.16 75.81 90.18

ALL 10 11.11 1.94 1.06 0.96 182.88 1047.29 1916.75 2116.41

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units 50% 10% 50% 10%

Cancer

LADD pot 3.46E-06 3.91E-05 mg/kg/day 0.00 0.00 mg/kg/day

LADC pot 1.77E-04 2.00E-03 mg/L 0.00 0.00 mg/kg

Acute

ADR pot 3.86E-03 8.75E-02 mg/kg/day 0.00 0.00 mg/kg/day

SIC Code Comments:6/3/2009 Page of

INITIAL EXPOSURE REVIEW REPORT Chemical ID: P090373cation

DRINKING WATER EXPOSURE ESTIMATES FROM LANDFILL RELEASES

SCENARIO #: 3 ACTIVITY: max ADR, max Acute Eco, max LADD

RELEASE DESCRIPTION:
EXPOSED POPULATION: Adult

NUMBER OF SITES NON-SLUDGE LANDFILL RELEASE AND DAYS OF RELEASE (kg/site/day)/(days) LANDFILLED SLUDGE 1 AND DAYS OF RELEASE (kg/site/day)/(days) MIGRATION DESCRIPTOR 2 ADSORPTION TO WASTEWATER SLUDGE (%) DRINKING WATER TREATMENT (%)

Slow 0.00 0.00

1 Landfilled sludge equals the fraction adsorbed to wastewater treatment sludge times the surface water pre-treatment release.

2 Migration Descriptor Log Koc Groundwater Concentration (GWC) (mg/L per kg release) Negligible no migration None Negligible to slow > 4.5 3.21E-6 Slow <4.5 to 3.5 2.67E-5 Moderate <3.5 to 2.5 5.95E-5 Rapid <2.5 7.55E-5

ASSUMPTIONS Exposure Units Results ED (years) AT (years) BW (kg) IR (L/day) Cancer LADD pot (mg/kg/day) 6.55E-05 30.00 75.00 71.80 1.40 LADC pot (mg/L) 3.36E-03 30.00 75.00 NA NA

REMARKS:6/3/2009 Page of



## LEGEND FOR NEW CHEMICAL S EXPOSURE REPORT

This new chemicals exposure report wa s prepared by the Exposure Assessment Branch (EAB) of the Economics, Exposure and Technology Division, Office of Pollution Prevention and Toxics, USEPA.
The goals of these reports are to calcula te conservative (protective) estimates of exposure endpoints for consumers, the general population, and the environment.
For each exposure scenario to industrial releases, the following three endpoints are calculated: (1) maximum possible acute concentrations and doses (2) maximum possible chronic concentrations and doses (3) for water releases ≥ 20 days, the probability of exceedence of the aquatic concentration of concern These endpoints are identified by abbreviati ons on the Release Activity line, e.g., (1) max ADR , (2) max LADD , (3) max PDM . Depending on the release inputs, these e ndpoints may be calculated and presented on the same page or different pages. That is, a release activity ID of mfg; max ADR, max PDM, max LADD indicates that all the exposure endpoints were cal culated from common manufacturing release values; conversely, a release activity ID of mfg &proc; max ADR indicates that only the maximum acute exposure values were calculated for manufacturing and proce ssing releases that occurred at the same site.
For each consumer product use exposure scenario, whether exposure is to the user directly or to the general population/environment, the maximum exposure values are calculated and presented together.
In addition to the exposure values above, EPA policy dir ects that exposure and release values be compared to criteria threshold values for Exposure-based and PBT Exposure-based cases.
Exposure-based (YX) cases (those with ≥ 100,000 kg/yr production volume) Criteria are exceeded under the following conditions: Presence in consumer product with likely exposure ≥ 3E-3 mg/kg/d exposure via air, fish ingestion or drinking water ≥ 10,000 kg/yr release to environment (post-treatment) ≥ 1,000 kg/yr release to water (post-treatment)
Persistent, Bioaccumulative, Toxic (PBT) chemical s of P2B2 rating or hi gher and production volume ≥ 20,000 kg/yr Criteria are exceeded as for YX cases, with the following differences: ≥ 2,000 kg/yr release to environment (post-treatment) ≥ 200 kg/yr release to water (post-treatment)
Bolding rules in the Report: Values for endpoints above th at are also health or eco concerns are bolded.