FIG 2 SUPPL

pollutant MALabel gene beta p valuelower IC upper IC beta p valuelower CI upper CI

no2 interaction cratpos1p50 0.68 0.57 ‐1.67 3.04 0.89 0.50 ‐1.68 3.47

no2 lower than median cratpos1p50 ‐4.82 0.00 ‐7.36 ‐2.29 ‐5.58 0.00 ‐8.35 ‐2.81

no2 higher than median cratpos1p50 ‐4.14 0.00 ‐6.54 ‐1.74 ‐4.69 0.00 ‐7.31 ‐2.06

no2 interaction cratpos2p50 2.02 0.09 ‐0.31 4.35 1.88 0.15 ‐0.65 4.42

no2 lower than median cratpos2p50 ‐5.53 0.00 ‐8.11 ‐2.95 ‐6.16 0.00 ‐8.98 ‐3.34

no2 higher than median cratpos2p50 ‐3.52 0.00 ‐5.87 ‐1.17 ‐4.29 0.00 ‐6.85 ‐1.71

no2 interaction crat_meanp5 1.87 0.12 ‐0.47 4.21 1.81 0.16 ‐0.74 4.37

no2 lower than median crat_meanp5 ‐5.44 0.00 ‐7.99 ‐2.89 ‐6.02 0.00 ‐8.80 ‐3.23

no2 higher than median crat_meanp5 ‐3.58 0.00 ‐5.96 ‐1.19 ‐4.22 0.00 ‐6.81 ‐1.61

no2 interaction f3pos1p50 ‐0.46 0.72 ‐2.97 2.06 ‐0.87 0.54 ‐3.63 1.90

no2 lower than median f3pos1p50 ‐5.05 0.00 ‐7.82 ‐2.27 ‐5.73 0.00 ‐8.79 ‐2.66

no2 higher than median f3pos1p50 ‐5.50 0.00 ‐7.98 ‐3.03 ‐6.59 0.00 ‐9.32 ‐3.86

no2 interaction f3pos2p50 0.05 0.97 ‐2.52 2.63 ‐0.17 0.91 ‐3.00 2.68

no2 lower than median f3pos2p50 ‐5.58 0.00 ‐8.30 ‐2.85 ‐6.45 0.00 ‐9.46 ‐3.44

no2 higher than median f3pos2p50 ‐5.53 0.00 ‐8.06 ‐2.99 ‐6.62 0.00 ‐9.42 ‐3.81

no2 interaction f3pos3p50 0.53 0.69 ‐2.02 3.08 1.22 0.39 ‐1.60 4.05

no2 lower than median f3pos3p50 ‐5.46 0.00 ‐8.26 ‐2.66 ‐6.77 0.00 ‐9.87 ‐3.66

no2 higher than median f3pos3p50 ‐4.94 0.00 ‐7.43 ‐2.44 ‐5.55 0.00 ‐8.30 ‐2.79

no2 interaction f3pos4p50 0.38 0.77 ‐2.19 2.94 0.87 0.55 ‐1.97 3.71

no2 lower than median f3pos4p50 ‐5.55 0.00 ‐8.45 ‐2.64 ‐6.82 0.00 ‐10.03 ‐3.60

no2 higher than median f3pos4p50 ‐5.17 0.00 ‐7.59 ‐2.75 ‐5.95 0.00 ‐8.63 ‐3.27

no2 interaction f3pos5p50 ‐1.71 0.19 ‐4.26 0.84 ‐0.96 0.50 ‐3.79 1.87

no2 lower than median f3pos5p50 ‐4.16 0.00 ‐6.93 ‐1.39 ‐5.57 0.00 ‐8.65 ‐2.49

no2 higher than median f3pos5p50 ‐5.87 0.00 ‐8.35 ‐3.37 ‐6.53 0.00 ‐9.29 ‐3.76

no2 interaction f3_meanp50 0.25 0.85 ‐2.32 2.82 1.14 0.43 ‐1.70 3.99

no2 lower than median f3_meanp50 ‐5.38 0.00 ‐8.29 ‐2.45 ‐6.90 0.00 ‐10.13 ‐3.66

no2 higher than median f3_meanp50 ‐5.13 0.00 ‐7.54 ‐2.71 ‐5.76 0.00 ‐8.43 ‐3.09

no2 interaction gcrpos1p50 ‐0.15 0.90 ‐2.56 2.25 ‐0.79 0.54 ‐3.32 1.74

no2 lower than median gcrpos1p50 ‐4.07 0.00 ‐6.72 ‐1.42 ‐4.06 0.00 ‐6.86 ‐1.26

no2 higher than median gcrpos1p50 ‐4.23 0.00 ‐6.83 ‐1.62 ‐4.85 0.00 ‐7.61 ‐2.09

no2 interaction icampos1p50 ‐1.59 0.24 ‐4.21 1.04 ‐0.34 0.82 ‐3.26 2.60

no2 lower than median icampos1p50 ‐4.59 0.00 ‐7.31 ‐1.86 ‐5.71 0.00 ‐8.74 ‐2.67

no2 higher than median icampos1p50 ‐6.17 0.00 ‐8.87 ‐3.46 ‐6.04 0.00 ‐9.06 ‐3.02

no2 interaction icampos2p50 0.25 0.85 ‐2.40 2.90 1.11 0.46 ‐1.83 4.06

no2 lower than median icampos2p50 ‐5.56 0.00 ‐8.39 ‐2.73 ‐6.56 0.00 ‐9.70 ‐3.40

no2 higher than median icampos2p50 ‐5.31 0.00 ‐7.93 ‐2.69 ‐5.45 0.00 ‐8.36 ‐2.52

no2 interaction icampos3p50 0.49 0.71 ‐2.11 3.09 0.67 0.65 ‐2.22 3.56

no2 lower than median icampos3p50 ‐5.80 0.00 ‐8.44 ‐3.15 ‐6.39 0.00 ‐9.34 ‐3.44

no2 higher than median icampos3p50 ‐5.31 0.00 ‐8.08 ‐2.54 ‐5.73 0.00 ‐8.81 ‐2.63

no2 interaction icam_meanp5 0.03 0.99 ‐2.59 2.64 0.75 0.61 ‐2.16 3.67

no2 lower than median icam_meanp5 ‐5.50 0.00 ‐8.22 ‐2.78 ‐6.31 0.00 ‐9.34 ‐3.28

no2 higher than median icam_meanp5 ‐5.48 0.00 ‐8.18 ‐2.77 ‐5.57 0.00 ‐8.58 ‐2.55

no2 interaction ifnpos1p50 0.98 0.38 ‐1.23 3.18 1.54 0.21 ‐0.85 3.95

no2 lower than median ifnpos1p50 ‐5.04 0.00 ‐7.45 ‐2.62 ‐5.87 0.00 ‐8.50 ‐3.24

no2 higher than median ifnpos1p50 ‐4.06 0.00 ‐6.43 ‐1.69 ‐4.33 0.00 ‐6.91 ‐1.75

no2 interaction ifnpos2p50 0.06 0.96 ‐2.18 2.31 0.32 0.80 ‐2.13 2.77

no2 lower than median ifnpos2p50 ‐4.58 0.00 ‐7.03 ‐2.13 ‐5.23 0.00 ‐7.91 ‐2.55

no2 higher than median ifnpos2p50 ‐4.52 0.00 ‐6.86 ‐2.17 ‐4.91 0.00 ‐7.48 ‐2.35

no2 interaction ifn_meanp50 1.23 0.28 ‐1.02 3.48 1.25 0.31 ‐1.19 3.71

no2 lower than median ifn_meanp50 ‐5.13 0.00 ‐7.57 ‐2.70 ‐5.70 0.00 ‐8.36 ‐3.04

no2 higher than median ifn_meanp50 ‐3.91 0.00 ‐6.27 ‐1.55 ‐4.45 0.00 ‐7.03 ‐1.88

NO IPW

fvc fev1

analysis‐pgm1‐AP‐LF‐interaction methylation9909 interactions 2013_04_30 ‐ for EPA.xlsx

IntCurrMethylNoIpw

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no2 interaction il6pos1p50 0.58 0.60 ‐1.58 2.75 0.04 0.97 ‐2.29 2.36

no2 lower than median il6pos1p50 ‐4.85 0.00 ‐7.27 ‐2.43 ‐5.10 0.00 ‐7.71 ‐2.49

no2 higher than median il6pos1p50 ‐4.27 0.00 ‐6.59 ‐1.95 ‐5.06 0.00 ‐7.56 ‐2.56

no2 interaction il6pos2p50 ‐0.94 0.40 ‐3.12 1.24 ‐0.41 0.73 ‐2.75 1.94

no2 lower than median il6pos2p50 ‐4.02 0.00 ‐6.41 ‐1.63 ‐4.83 0.00 ‐7.40 ‐2.25

no2 higher than median il6pos2p50 ‐4.96 0.00 ‐7.32 ‐2.60 ‐5.24 0.00 ‐7.78 ‐2.69

no2 interaction il6_meanp50 ‐0.79 0.47 ‐2.93 1.35 ‐0.60 0.61 ‐2.90 1.71

no2 lower than median il6_meanp50 ‐4.16 0.00 ‐6.54 ‐1.77 ‐4.81 0.00 ‐7.39 ‐2.23

no2 higher than median il6_meanp50 ‐4.95 0.00 ‐7.28 ‐2.61 ‐5.41 0.00 ‐7.92 ‐2.88

no2 interaction inospos1p50 ‐1.03 0.45 ‐3.72 1.66 0.19 0.90 ‐2.83 3.22

no2 lower than median inospos1p50 ‐4.54 0.00 ‐7.62 ‐1.46 ‐5.18 0.00 ‐8.64 ‐1.71

no2 higher than median inospos1p50 ‐5.57 0.00 ‐8.52 ‐2.61 ‐4.99 0.00 ‐8.31 ‐1.66

no2 interaction inospos2p50 ‐0.96 0.52 ‐3.88 1.97 ‐1.41 0.40 ‐4.68 1.86

no2 lower than median inospos2p50 ‐4.78 0.00 ‐7.81 ‐1.74 ‐4.45 0.01 ‐7.85 ‐1.05

no2 higher than median inospos2p50 ‐5.73 0.00 ‐8.86 ‐2.60 ‐5.86 0.00 ‐9.36 ‐2.35

no2 interaction inos_meanp5 ‐0.78 0.59 ‐3.59 2.05 ‐0.42 0.79 ‐3.59 2.75

no2 lower than median inos_meanp5 ‐4.83 0.00 ‐7.89 ‐1.76 ‐4.99 0.00 ‐8.43 ‐1.54

no2 higher than median inos_meanp5 ‐5.60 0.00 ‐8.63 ‐2.56 ‐5.41 0.00 ‐8.82 ‐2.00

no2 interaction oggpos1p50 ‐1.72 0.27 ‐4.75 1.32 ‐1.60 0.37 ‐5.07 1.89

no2 lower than median oggpos1p50 ‐3.61 0.03 ‐6.83 ‐0.38 ‐3.83 0.04 ‐7.52 ‐0.13

no2 higher than median oggpos1p50 ‐5.33 0.00 ‐8.43 ‐2.22 ‐5.42 0.00 ‐8.97 ‐1.86

no2 interaction oggpos2p50 ‐0.75 0.64 ‐3.88 2.37 ‐0.65 0.72 ‐4.24 2.95

no2 lower than median oggpos2p50 ‐3.90 0.02 ‐7.07 ‐0.71 ‐4.22 0.02 ‐7.86 ‐0.57

no2 higher than median oggpos2p50 ‐4.65 0.01 ‐7.94 ‐1.35 ‐4.87 0.01 ‐8.64 ‐1.09

no2 interaction oggpos3p50 0.14 0.93 ‐2.75 3.03 0.50 0.77 ‐2.82 3.84

no2 lower than median oggpos3p50 ‐4.54 0.00 ‐7.69 ‐1.38 ‐4.94 0.01 ‐8.55 ‐1.33

no2 higher than median oggpos3p50 ‐4.40 0.01 ‐7.52 ‐1.28 ‐4.44 0.02 ‐8.02 ‐0.86

no2 interaction oggpos4p50 ‐1.73 0.23 ‐4.57 1.11 ‐2.08 0.21 ‐5.34 1.19

no2 lower than median oggpos4p50 ‐3.56 0.03 ‐6.72 ‐0.39 ‐3.57 0.05 ‐7.20 0.07

no2 higher than median oggpos4p50 ‐5.28 0.00 ‐8.35 ‐2.22 ‐5.64 0.00 ‐9.15 ‐2.12

no2 interaction ogg_meanp50 ‐2.28 0.14 ‐5.32 0.76 ‐1.86 0.30 ‐5.35 1.65

no2 lower than median ogg_meanp50 ‐3.43 0.03 ‐6.56 ‐0.28 ‐3.89 0.03 ‐7.49 ‐0.28

no2 higher than median ogg_meanp50 ‐5.70 0.00 ‐8.93 ‐2.46 ‐5.74 0.00 ‐9.45 ‐2.03

no2 interaction tlr2pos1p50 ‐0.11 0.93 ‐2.64 2.42 0.27 0.85 ‐2.51 3.05

no2 lower than median tlr2pos1p50 ‐4.43 0.00 ‐7.18 ‐1.69 ‐5.37 0.00 ‐8.39 ‐2.34

no2 higher than median tlr2pos1p50 ‐4.55 0.00 ‐7.10 ‐1.99 ‐5.10 0.00 ‐7.91 ‐2.29

no2 interaction tlr2pos2p50 0.25 0.85 ‐2.29 2.80 0.44 0.76 ‐2.36 3.24

no2 lower than median tlr2pos2p50 ‐4.57 0.00 ‐7.26 ‐1.87 ‐5.37 0.00 ‐8.33 ‐2.41

no2 higher than median tlr2pos2p50 ‐4.31 0.00 ‐6.91 ‐1.72 ‐4.93 0.00 ‐7.78 ‐2.08

no2 interaction tlr2pos3p50 ‐1.15 0.38 ‐3.72 1.42 ‐1.30 0.37 ‐4.12 1.53

no2 lower than median tlr2pos3p50 ‐3.87 0.01 ‐6.57 ‐1.16 ‐4.51 0.00 ‐7.48 ‐1.53

no2 higher than median tlr2pos3p50 ‐5.01 0.00 ‐7.61 ‐2.42 ‐5.80 0.00 ‐8.66 ‐2.94

no2 interaction tlr2pos4p50 1.18 0.37 ‐1.40 3.76 2.75 0.06 ‐0.09 5.59

no2 lower than median tlr2pos4p50 ‐5.01 0.00 ‐7.69 ‐2.33 ‐6.55 0.00 ‐9.49 ‐3.59

no2 higher than median tlr2pos4p50 ‐3.84 0.00 ‐6.45 ‐1.22 ‐3.81 0.01 ‐6.68 ‐0.93

no2 interaction tlr2pos5p50 ‐2.14 0.10 ‐4.70 0.43 ‐3.25 0.02 ‐6.05 ‐0.43

no2 lower than median tlr2pos5p50 ‐3.47 0.01 ‐6.07 ‐0.87 ‐3.71 0.01 ‐6.56 ‐0.85

no2 higher than median tlr2pos5p50 ‐5.60 0.00 ‐8.29 ‐2.90 ‐6.94 0.00 ‐9.91 ‐3.98

no2 interaction tlr2_meanp5 1.44 0.28 ‐1.20 4.09 1.16 0.43 ‐1.75 4.08

no2 lower than median tlr2_meanp5 ‐5.29 0.00 ‐8.03 ‐2.56 ‐5.86 0.00 ‐8.88 ‐2.84

no2 higher than median tlr2_meanp5 ‐3.86 0.00 ‐6.45 ‐1.26 ‐4.71 0.00 ‐7.56 ‐1.84

analysis‐pgm1‐AP‐LF‐interaction methylation9909 interactions 2013_04_30 ‐ for EPA.xlsx

IntCurrMethylNoIpw

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