Exhibit
10.10


 


SECOND
AMENDMENT TO THE


 


ASSIGNMENT
AND ASSUMPTION AGREEMENT (NON-U.S.)


 


THIS
SECOND AMENDMENT TO THE ASSIGNMENT AND ASSUMPTION AGREEMENT (NON-U.S.) (this “Amendment”) is made and entered into
as of October 2, 2020, by and among Jay Pharma Inc., a Canada corporation (“Company”), Tikkun Pharma, Inc., a Delaware
corporation (“TP”), and Tikun Olam IP Ltd., a Cayman Islands company (“TOCI”), and amends that
certain Assignment and Assumption Agreement, dated as of January 10, 2020 (the “Assignment and Assumption Agreement”),
by and among Company, TP and TOCI, as amended by that certain First Amendment to the Assignment and Assumption Agreement (Non-U.S.),
dated as of August 12, 2020 (the “First Amendment” and, together with the Assignment and Assumption Agreement, the
“Agreement”). Capitalized terms used but not defined herein have their respective meanings set forth in the Agreement.


 


1. Amendments.
In accordance with the terms and conditions of the Agreement, the Agreement shall be amended as follows, effective as of the date hereof:


 


	 	a.	The
    Recitals to the Agreement are hereby deleted and replaced in their entirety by the following:


 


“WHEREAS,
TP has previously entered into that certain Amended and Restated Sublicense Agreement (Non-U.S.) dated January 12, 2018 (as amended by
that certain First Amendment dated January 10, 2020, the “Sublicense”), pursuant to which TOCI sublicensed to TP certain
rights in-licensed from Tikun Olam, Ltd., an Israeli corporation with registration number 514263771;


 


WHEREAS,
in exchange for certain equity consideration as further described herein, TP wishes to transfer and assign to JP, and JP wishes to receive
and assume from TP, any and all of TP’s rights and responsibilities under the Sublicense;


 


WHEREAS,
JP has entered into a Securities Purchase Agreement, dated as of the date hereof (the “SPA”), with certain other parties
signatory thereto and it is the express intention of the parties hereto that the transactions contemplated hereby will be consummated
upon the satisfaction of the conditions to the closing of transactions contemplated by the SPA.


 


NOW,
THEREFORE, in consideration of the mutual covenants contained in this Agreement, and for other good and valuable consideration, the
receipt and adequacy of which are hereby acknowledged, the Parties hereby agree as follows:”


 


	 	b.	Section 5.1 of the Agreement
    shall be deleted and replaced in its entirety by the following:


 


“5.1 Definition
of Effective Date. For purposes of this Agreement, “Effective Date” means the date the Second Amendment to this
Agreement is executed by the parties. For the avoidance of doubt, in all cases, the Effective Date shall be deemed to have occurred prior
to the consummation of the SPA. If the consummation of the SPA has not occurred by January 1, 2021, any party hereto may terminate this
Agreement by delivering written notice to the other parties.” 


 


2. Effect
of Amendment. Except as specifically set forth in this Amendment, all of the terms, provisions, representations, warranties, covenants
and conditions contained in the Agreement shall remain unmodified and unwaived by the terms of this Amendment, and shall remain in full
force and effect in accordance with their respective terms, and are hereby ratified, approved and confirmed in all respects. This Amendment
shall not constitute any party’s consent or indicate its willingness to consent to any other amendment, modification or waiver
of the Agreement, the schedules thereto or any instruments or agreements referred to herein or therein. This Amendment is supplemental
to the Agreement and does, and shall be deemed to, form a part of, and shall be construed in connection with and as a part of, the Agreement
for any and all purposes.


 


3. Counterparts.
This Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all such counterparts together
shall constitute one and the same instrument. Facsimile or pdf copies of original signatures shall be as effective as originals.


 


[Signature
Pages Follow]


 






    	 



    	 



    

 





IN
WITNESS WHEREOF the parties have executed this Amendment as of the date first written above.


 


	TIKKUN PHARMA, INC.	 	JAY PHARMA, INC.
	 	 	 	 	 
	By:	/s/ Barry
    Farkas	 	By:	/s/ Henoch
    Cohn
	 	 	 	 	 
	Name:	Barry Farkas	 	Name:	Henoch Cohn
	 	 	 	 	 
	Title:	Authorized
    Signatory	 	Title:	President


 


	TIKUN OLAM IP LTD.	 
	 	 	 
	By:	TO Pharmaceuticals LLC, its manager	 
	By:	TO Holding Group LLC, its manager	 
	By:	TO Global LLC, its manager	 


 


	By:	/s/
    Bernard Sucher	 
	 	 	 
	Name:	Bernard Sucher	 
	 	 	 
	Title:	Manager	 


 


Signature
Page to


Second
Amendment to the Assignment and Assumption Agreement (Non-U.S.)