2756 Federal Register / Vol. 72, No. 13 / Monday, January 22, 2007 / Notices 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPPT–2006–0961; FRL–8110–2] 

Fifty-Ninth Report of the TSCA 

Interagency Testing Committee to the 

Administrator of the Environmental 

Protection Agency; Receipt of Report 

and Request for Comments 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: The Toxic Substances Control 

Act (TSCA) Interagency Testing 

Committee (ITC) transmitted its 59th ITC 

Report to the Administrator of EPA on 

December 13, 2006. In the 59th ITC 

Report, which is included with this 

notice, the ITC is revising the TSCA 

section 4(e) Priority Testing List by 

removing 22 chemicals. Phenol, 4-(1,1- 

dimethylethyl)- is being removed 

because a recently submitted 

reproductive effects study meets ITC’s 

data needs. Five tungsten compounds 

and 16 chemicals with insufficient 

dermal absorption rate data are being 

removed because their production 

volumes or worker numbers indicate 

low potential for occupational 

exposures. 

DATES: Comments must be received on 

or before February 21, 2007. 

ADDRESSES: Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPPT–2006–0961, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Document Control Office 

(7407M), Office of Pollution Prevention 

and Toxics (OPPT), Environmental 

Protection Agency, 1200 Pennsylvania 

Ave., NW., Washington, DC 20460– 

0001. 

• Hand Delivery: OPPT Document 

Control Office (DCO), EPA East Bldg., 

Rm. 6428, 1201 Constitution Ave., NW., 

Washington, DC. Attention: Docket ID 

Number EPA–HQ–OPPT–2006–0961. 

The DCO is open from 8 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The telephone number for the 

DCO is (202) 564–8930. Such deliveries 

are only accepted during the DCO’s 

normal hours of operation, and special 

arrangements should be made for 

deliveries of boxed information. 

Instructions: Direct your comments to 

docket ID number EPA–HQ–OPPT– 

2006–0961. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov website is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD-ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. For additional information 

about EPA’s public docket, visit the EPA 

Docket Center homepage at http:// 

www.epa.gov/epahome/dockets.htm. 

Docket: All documents in the docket 

are listed in the docket’s index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

will be publicly available only in hard 

copy. Publicly available docket 

materials are available electronically at 

http://www.regulations.gov, or, if only 

available in hard copy, at the OPPT 

Docket. The OPPT Docket is located in 

the EPA Docket Center (EPA/DC) at Rm. 

3334, EPA West Bldg., 1301 

Constitution Ave., NW., Washington, 

DC. The EPA/DC Public Reading Room 

hours of operation are 8:30 a.m. to 4:30 

p.m., Monday through Friday, excluding 

Federal holidays. The telephone number 

of the EPA/DC Public Reading Room is 

(202) 566–1744, and the telephone 

number for the OPPT Docket is (202) 

566–0280. Docket visitors are required 

to show photographic identification, 

pass through a metal detector, and sign 

the EPA visitor log. All visitor bags are 

processed through an X-ray machine 

and subject to search. Visitors will be 

provided an EPA/DC badge that must be 

visible at all times in the building and 

returned upon departure. 

For submission of studies, see Unit 

IV.A.1. of the SUPPLEMENTARY

INFORMATION. 

FOR FURTHER INFORMATION CONTACT: 

Colby Lintner, Regulatory Coordinator, 

Environmental Assistance Division 

(7408M), Office of Pollution Prevention 

and Toxics, Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001; telephone 

number: (202) 554–1404; e-mail address: 

TSCA-Hotline@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this Action Apply to Me? 

This notice is directed to the public 

in general. It may, however, be of 

particular interest to you if you 

manufacture (defined by statute to 

include import) and/or process TSCAcovered chemicals and you may be 

identified by the North American 

Industrial Classification System 

(NAICS) codes 325 and 32411. Because 

this notice is directed to the general 

public and other entities may also be 

interested, the Agency has not 

attempted to describe all the specific 

entities that may be interested in this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the person 

listed under FOR FURTHER INFORMATION

CONTACT. 

B. What Should I Consider as I Prepare 

My Comments for EPA? 

1. Submitting CBI. Do not submit this 

information to EPA through 

regulations.gov or e-mail. Clearly mark 

the part or all of the information that 

you claim to be CBI. For CBI 

information in a disk or CD ROM that 

you mail to EPA, mark the outside of the 

disk or CD ROM that you mail to EPA, 

mark the outside of the disk or CD ROM 

as CBI and then identify electronically 

within the disk or CD ROM the specific 

information that is claimed as CBI. In 

addition to one complete version of the 

comment that includes information 

claimed as CBI, a copy of the comment 

that does not contain the information 

claimed as CBI must be submitted for 

inclusion in the public docket. 

Information so marked will not be 

disclosed except in accordance with 

procedures set forth in 40 CFR part 2. 

2. Tips for preparing your comments. 

When submitting comments, remember 

to: 

i. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

ii. Follow directions. The Agency may 

ask you to respond to specific questions 


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or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

iii. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

iv. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

v. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

vi. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

vii. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

viii. Make sure to submit your 

comments by the comment period 

deadline identified. 

II. Background 

The Toxic Substances Control Act 

(TSCA) (15 U.S.C. 260l et seq.) 

authorizes the Administrator of EPA to 

promulgate regulations under section 

4(a) of TSCA requiring testing of 

chemicals and chemical groups in order 

to develop data relevant to determining 

the risks that such chemicals and 

chemical groups may present to health 

or the environment. Section 4(e) of 

TSCA established the ITC to 

recommend chemicals and chemical 

groups to the Administrator of EPA for 

priority testing consideration. Section 

4(e) of TSCA directs the ITC to revise 

the TSCA section 4(e) Priority Testing 

List at least every 6 months. 

You may access additional 

information about the ITC at http:// 

www.epa.gov/opptintr/itc. 

A. The ITC’s 59th Report 

The ITC is revising the TSCA section 

4(e) Priority Testing List by removing 22 

chemicals. Phenol, 4-(1,1- 

dimethylethyl)- is being removed 

because a recently submitted 

reproductive effects study meets ITC’s 

data needs. Five tungsten compounds 

and sixteen chemicals with insufficient 

dermal absorption rate data are being 

removed because their production 

volumes or worker numbers indicate 

low potential for occupational 

exposures. 

B. Status of the Priority Testing List 

The Priority Testing List includes 2 

alkylphenols, 5 tungsten compounds, 16 

chemicals with insufficient dermal 

absorption rate data and 243 High 

Production Volume (HPV) Challenge 

Program orphan chemicals. 

List of Subjects 

Environmental protection, Chemicals, 

Hazardous substances. 

Dated: January 12, 2007. 

Charles M. Auer, 

Director, Office of Pollution Prevention and 

Toxics. 

Fifty-Ninth Report of the TSCA 

Interagency Testing Committee to the 

Administrator, U.S. Environmental 

Protection Agency 

Table of Contents 

Summary 

I. Background 

II. TSCA Section 8 Reporting 

A. TSCA Section 8 Reporting Rules 

B. ITC’s Use of TSCA Section 8 and Other 

Information 

C. Previous Requests to Add Chemicals to the 

TSCA Section 8(a) PAIR Rule and TSCA 

Section 8(d) HaSDR Rule 

III. ITC’s Activities During this Reporting 

Period (June to November 2006) 

IV. Revisions to the TSCA Section 4(e) 

Priority Testing List: Chemicals 

Removed from the Priority Testing List 

1. Chemicals with insufficient dermal 

absorption rate data. 

2. Phenol, 4-(1,1-dimethylethyl)-. 

3. Tungsten compounds. 

V. References 

VI. The TSCA Interagency Testing Committee 

Summary 

The ITC is revising the Toxic Substances 

Control Act (TSCA) section 4(e) Priority 

Testing List by removing 22 chemicals. 

Phenol, 4-(1,1-dimethylethyl)- is being 

removed because a recently submitted 

reproductive effects study meets ITC’s data 

needs. Five tungsten compounds and sixteen 

chemicals with insufficient dermal 

absorption rate data are being removed 

because their production volumes or worker 

numbers indicate low potential for 

occupational exposures. 

The TSCA section 4(e) Priority Testing List 

is Table 1 of this unit. 

TABLE 1.—TSCA SECTION 4(E) PRIORITY TESTING LIST (NOVEMBER 2006) 

ITC Report Date Chemical name/group Action 

31 January 1993 2 Chemicals with insufficient dermal absorption rate data Designated 

32 May 1993 10 Chemicals with insufficient dermal absorption rate data Designated 

35 November 1994 4 Chemicals with insufficient dermal absorption rate data Designated 

37 November 1995 Branched 4-nonylphenol (mixed isomers) Recommended 

41 November 1997 Phenol, 4-(1,1,3,3-tetramethylbutyl)- Recommended 

53 November 2003 5 Tungsten compounds Recommended 

55 December 2004 238 High Production Volume (HPV) Challenge Program orphan chemicals Recommended 

56 August 2005 5 HPV Challenge Program orphan chemicals Recommended 

I. Background 

The ITC was established by section 4(e) of 

TSCA ‘‘to make recommendations to the 

Administrator respecting the chemical 

substances and mixtures to which the 

Administrator should give priority 

consideration for the promulgation of rules 

for testing under section 4(a).... At least every 

six months ..., the Committee shall make 

such revisions to the Priority Testing List as 

it determines to be necessary and transmit 

them to the Administrator together with the 

Committee’s reasons for the revisions’’

(Public Law 94–469, 90 Stat. 2003 et seq., 15 


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U.S.C. 2601 et seq.). ITC Reports are available 

from the ITC’s website (http://www.epa.gov/ 

opptintr/itc) within a few days of submission 

to the EPA Administrator and from the EPA’s 

website (http://www.epa.gov/fedrgstr) after 

publication in the Federal Register. The ITC 

produces its revisions to the Priority Testing 

List with administrative and technical 

support from the ITC staff, ITC members, and 

their U.S. Government organizations, and 

contract support provided by EPA. ITC 

members and staff are listed at the end of this 

report. 

II. TSCA Section 8 Reporting 

A. TSCA Section 8 Reporting Rules 

Following receipt of the ITC’s report (and 

the revised Priority Testing List) by the EPA 

Administrator, the EPA’s Office of Pollution 

Prevention and Toxics (OPPT) may add the 

chemicals from the revised Priority Testing 

List to the TSCA section 8(a) Preliminary 

Assessment Information Reporting (PAIR) or 

TSCA section 8(d) Health and Safety Data 

Reporting (HaSDR) rules. The PAIR rule 

requires manufacturers (including importers) 

of chemicals added to the Priority Testing 

List to submit production and exposure 

reports (http://www.epa.gov/opptintr/ 

chemtest/pubs/pairform.pdf). The HaSDR 

rule requires manufacturers (including 

importers) and can require processors of 

chemicals added to the Priority Testing List 

to submit unpublished health and safety 

studies under TSCA section 8(d) that must be 

in compliance with the revised HaSDR rule 

(Ref. 1). 

B. ITC’s Use of TSCA Section 8 and Other 

Information 

The ITC’s use of TSCA section 8 and other 

information is described in the 52nd ITC 

Report (http://www.epa.gov/opptintr/itc). 

C. Previous Requests to Add Chemicals to the 

TSCA Section 8(a) PAIR Rule and TSCA 

Section 8(d) HaSDR Rule 

In its 56th ITC Report the ITC requested 

that EPA add 243 of the 251 HPV Challenge 

Program orphan chemicals on the Priority 

Testing List to TSCA section 8(a) PAIR and 

8(d) HaSDR rules (Ref. 2). In its 58th ITC 

Report the ITC removed the 8 HPV Challenge 

Program orphan chemicals listed in Tables 2 

and 3 of the 56th ITC Report from the Priority 

Testing List and requested that EPA not add 

them to the TSCA section 8(a) PAIR and 8(d) 

HaSDR rules (Ref. 3). Additional information 

on the HPV Challenge Program orphan 

chemicals and EPA’s September 2006 

amended Policy Regarding Acceptance of 

New Commitments to Sponsor Chemicals 

under the HPV Challenge Program is 

available at http://www.epa.gov/hpv/pubs/ 

general/hpvpolcy2.htm. 

III. ITC’s Activities During this Reporting 

Period (June to November 2006) 

In its 56th and 58th ITC Reports, the ITC 

appended lists of new HPV chemicals with 

1998 or 2002 Inventory Update Rule (IUR) 

production or importation volume data 

greater than or equal to 1 million pounds 

(Refs. 2 and 3). In response to public 

comments, the ITC made available on its 

website (http://www.epa.gov/opptintr/itc) the 

sources of publicly available health effects 

and environmental data for new HPV 

chemicals. The ITC provided these data 

sources to facilitate the efforts of Federal and 

State agencies, interested stakeholders, and 

members of the public to obtain basic health 

effects and environmental data for new HPV 

chemicals. 

Despite efforts to provide these data 

sources for new HPV chemicals, appending 

these lists to the 56th and 58th ITC Reports 

(Refs. 2 and 3) caused confusion. The ITC 

regrets the confusion caused by these efforts 

and therefore provides the following 

clarifications: 

•The ITC intentionally listed these new 

HPV chemicals in appendices and did not 

add them to the TSCA section 4(e) Priority 

Testing List. 

•The EPA promulgates TSCA section 8(a) 

and TSCA 8(d) rules for ITC chemicals only 

after they have been added to the TSCA 

section 4(e) Priority Testing List. 

•The ITC requests comments from readers 

who found the sources of basic health effects 

and environmental data for new HPV 

chemicals either useful or not useful, and if 

useful, how the sources were used. 

During this reporting period, the ITC 

discussed: 

•Chemicals with insufficient dermal 

absorption rate data. 

• Alkylphenols. 

•Tungsten compounds. 

•Brominated flame retardants. 

• Health-based screening levels. 

•Tetrahydrofuran. 

• Methyl iodide. 

•Chlorine dioxide. 

IV. Revisions to the TSCA Section 4(e) 

Priority Testing List: Chemicals Removed 

from the Priority Testing List 

1. Chemicals with insufficient dermal 

absorption rate data. In its 31st, 32nd, and 

35th ITC Reports, the ITC added 24, 34, and 

25 chemicals, respectively, to the Priority 

Testing List and designated them for testing 

to develop dermal absorption rate data (Refs. 

4, 5, and 6). The ITC removed methyl 

methacrylate and diethyl phthalate from the 

Priority Testing List in its 34th ITC Report 

(Ref. 7) and cyclohexanone from the Priority 

Testing List in its 36th ITC Report (Ref. 8). 

Methyl methacrylate, diethyl phthalate, and 

cyclohexanone were removed from the 

Priority Testing List because dermal 

absorption rate data were identified after 

these chemicals were added to the Priority 

Testing List. In its 45th ITC Report (Ref. 9), 

the ITC removed an additional 47 chemicals 

(designated for dermal absorption rate 

testing) from the Priority Testing List, because 

the EPA published a rule proposing dermal 

absorption rate testing for these chemicals 

(Ref. 10). In 2004, the EPA reviewed more 

recent production volume, exposure, and 

dermal absorption rate data and promulgated 

a rule requiring dermal absorption rate 

testing for 34 of these chemicals (Ref. 11). 

The rationales for EPA’s decision not to 

finalize testing requirements for the other 13 

chemicals in the proposed rule are described 

in reference 11. At this time, dermal 

absorption rate data have been developed for 

32 of the 34 chemicals. Dimethyl sulfate 

(CAS No. 77–78–1) was dropped from 

consideration because it was considered too 

corrosive to test. Nonane (CAS No. 111–84–

2) has been referred to EPA’s compliance 

staff because a letter of intent to commence 

testing has not been received. In this 59th ITC 

Report, the ITC is removing 16 chemicals 

with insufficient dermal absorption rate data 

from the Priority Testing List (See Table 2 of 

this unit.). 

TABLE 2.—CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION RATE

DATA BEING REMOVED FROM THE

PRIORITY TESTING LIST

CAS No. TSCA Inventory 

Name 

ITC Report 

61–82–5 1H-1,2,4-Triazol-3- 

amine 

32 

75–25–2 Methane, tribromo- 32 

75–34–3 Ethane, 1,1-dichloro- 32 

76–22–2 Bicyclo[2.2.1]heptan2-one, 1,7,7- 

trimethyl31 

99–65–0 Benzene, 1,3-dinitro- 32 

100–25–

4 

Benzene, 1,4-dinitro- 31 

105–46–

4 

Acetic acid, 1- 

methylpropyl ester 

31 

107–66–

4 

Phosphoric acid, 

dibutyl ester 

31 

110–83–

8 

Cyclohexene 31 

123–92–

2 

1-Butanol, 3-methyl-, 

acetate 

31 

532–27–

4 

Ethanone, 2-chloro-1- 

phenyl31 

540–88–

5 

Acetic acid, 1,1- 

dimethylethyl ester 

31 

1300–

73–8 

Benzenamine, ar,ardimethyl32 

6423–

43–4 

1,2-Propanediol, 

dinitrate 

32 

7631–

90–5 

Sulfurous acid, monosodium salt 31 

7681–

57–4 

Disulfurous acid, disodium salt 31 

Five of these chemicals had reported 

production volumes of < 500,000 pounds and 

11 had no production volumes reported to 

EPA in response to the 2002 IUR (Ref. 12). 

Further, 8 of the 11 chemicals with no 2002 

IUR data had no production volumes 

reported to EPA in response to the 1994 or 

1998 IURs (Refs. 13 and 14). The ITC is 

removing these 16 chemicals because their 


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production volumes indicate low potential 

for occupational exposures. 

There are 16 chemicals with insufficient 

dermal absorption rate data remaining on the 

Priority Testing List (See Table 3 of this 

unit.). 

TABLE 3.—CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION RATE DATA REMAINING ON THE PRIORITY TESTING LIST

CAS No. TSCA Inventory Name ITC Report Status 

75–12–7 Formamide 35 Screening Information Data Set (SIDS) & International Council of 

Chemical Associations (ICCA) 

88–72–2 Benzene, 1-methyl-2-nitro- 32 SIDS 

89–72–5 Phenol, 2-(1-methylpropyl)- 32 SIDS & HPV Challenge Program 

90–04–0 Benzenamine, 2-methoxy- 32 SIDS 

95–13–6 1H-Indene 32 American Chemistry Council (ACC), Soap and Detergent Association (SDA) & Synthetic Organic Chemical Manufacturers Association (SOCMA) Extended (E) HPV Challenge Program 

96–18–4 Propane, 1,2,3-trichloro- 35 SIDS & ICCA 

99–08–1 Benzene, 1-methyl-3-nitro- 35 Sponsored HPV chemical 

100–63–0 Hydrazine, phenyl- 32 Appendix A, 58th ITC Report 

106–49–0 Benzenamine, 4-methyl- 32 SIDS & ICCA 

108–44–1 Benzenamine, 3-methyl- 32 SIDS 

108–87–2 Cyclohexane, methyl- 31 Moderate production volume (MPV) 2002 chemical 

121–14–2 Benzene, 1-methyl-2,4-dinitro- 32 SIDS 

287–92–3 Cyclopentane 31 SIDS, ICCA, & HPV Challenge Program 

540–59–0 Ethene, 1,2-dichloro- 32 MPV 1998 & 2002 

542–92–7 1,3-Cyclopentadiene 35 HPV orphan chemical 

626–17–5 1,3-Benzenedicarbonitrile 32 Sponsored HPV chemical 

Twelve of the sixteen chemicals with 

insufficient dermal absorption rate data 

remaining on the Priority Testing List are 

included in EPA’s HPV Challenge Program, 

the Organization for Economic Cooperation 

and Development (OECD) SIDS Program, 

ICCA HPV Initiative, or the ACC, SDA, and 

SOCMA EHPV Program. 

Two of the sixteen chemicals with 

insufficient dermal absorption rate data 

remaining on the Priority Testing List are 

MPV chemicals (production or importation 

volumes ranging from 500,000 to 999,999 

pounds). One of the 16 chemicals, 

phenylhydrazine, was listed in Appendix A 

of the 58th ITC Report (Ref. 3) because it was 

a new HPV chemical in 2002. The last 

chemical, 1,3-cyclopentadiene is a HPV 

Challenge Program orphan chemical that 

remains on the Priority Testing List to 

provide potential sponsors the opportunity to 

voluntarily submit or develop data, including 

dermal absorption rate data. 

The ITC encourages the manufacturers or 

sponsors of the 16 chemicals in Table 3 of 

this unit to voluntarily develop dermal 

absorption rate data using the methods 

discussed in reference 11 and submit studies 

using one of the following methods: 

• Hand Delivery: John D. Walker, OPPT/ 

ITC (7401M), EPA, EPA East Bldg., Rm. 5353, 

1201 Constitution Ave., NW., Washington, 

DC. Attention: FYI-ITC. 

• Mail: Document Control Office (7407M), 

Office of Pollution Prevention and Toxics 

(OPPT), Environmental Protection Agency, 

1200 Pennsylvania Ave., NW., Washington, 

DC 20460–0001. Attention: FYI-ITC. 

2. Phenol, 4-(1,1-dimethylethyl)-. Eightyeight alkylphenols, polyalkylphenols, 

alkylphenol ethoxylates, and alkylphenol 

polyethoxylates were added to the Priority 

Testing List in the 37th, 39th, 41st, and 46th

ITC Reports (Refs. 18–21). Fifty of these 

chemicals were removed from the Priority 

Testing List in the 43rd, 46th, and 48th ITC 

Reports (Refs. 21–23) because: 

a. No domestic production or importation 

volumes were reported to the EPA in 

response to 1986, 1990, 1994, or 1998 IURs 

(Refs. 13, 14, 24, and 25), 

b. No domestic production or importation 

volumes were reported to the EPA in 

response to the February 28, 1996 PAIR rule 

(Ref. 26), 

c. No TSCA section 8(d) studies were 

submitted to the EPA in response to the 

February 28, 1996 HaSDR rule (Ref. 26), 

d. No domestic production or importation 

volumes were reported to the EPA in 

response to the January 11, 2000 PAIR rule 

(Ref. 27), 

e. No domestic production or importation 

volumes were reported to the EPA in 

response to the July 5, 2000 PAIR rule (Ref. 

28), 

f. No TSCA section 8(e) or FYI studies were 

available for these chemicals as of September 

1998, or 

g. Use and health and safety data were 

voluntarily submitted to the ITC by the 

Chemical Manufacturers Association 

Alkylphenols and Ethoxylates Panel. 

Thirty-five of these chemicals were 

removed from the Priority Testing List in the 

50th and 51st ITC Reports (Refs. 29 and 30) 

because: 

• No domestic production or importation 

volumes were reported to the EPA in 

response to 1986, 1990, 1994, and 1998 IURs 

(Refs. 13, 14, 24, and 25) or reported to the 

EPA in response to the July 5, 2000 PAIR rule 

(Ref. 28). 

• Data developed in response to the EPA’s 

HPV Challenge Program could be used to 

predict toxicity, or 

•The Alkyl Phenol Ethoxylates Research 

Consortium (http://www.aperc.org) provided 

information to meet the ITC’s data needs. 

The three remaining alkyphenols on the 

Priority Testing List are: Phenol, 4-(1,1- 

dimethylethyl)- (CAS No. 98–54–4); phenol, 

4-(1,1,3,3-tetramethylbutyl)- (CAS No. 140–

66–9); and phenol, 4-nonyl-, branched (CAS 

No. 84852–15–3) (Ref. 30). For phenol, 4-(1,1- 

dimethylethyl)-, the ITC anticipated 

receiving the ongoing reproductive effects 

study. For phenol, 4-(1,1,3,3- 


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tetramethylbutyl)- and phenol, 4-nonyl-, 

branched, the ITC anticipated receiving 

amphibian toxicity data, avian reproductive 

effects data, and fish reproductive effects 

data. 

The ITC received the recently completed 

2–generation reproductive effects study in 

rats for phenol, 4-(1,1-dimethylethyl)-, more 

commonly referred to as 4-tert-butylphenol 

(Ref. 31). The ITC is removing 4-tertbutylphenol from the Priority Testing List 

because the reproductive effects study meets 

the ITC’s data needs. 

There are amphibian toxicity data for 

phenol, 4-(1,1,3,3-tetramethylbutyl)- and 

phenol, 4-nonyl-, branched. In an amphibian 

toxicity study of phenol, 4-nonyl-, branched, 

the 96 hour LC50 for toad (Bufo boreas) 

tadpoles was 120 microgram/Liter (μg/L) 

(Ref. 32). Two amphibian toxicity studies of 

phenol, 4-(1,1,3,3-tetramethylbutyl)- were 

discussed in a recent review (Ref. 33). One 

was categorized as ‘‘not valid’’ (Ref. 34) and 

the other as ‘‘use with care’’ (Ref. 35). These 

studies may be sufficient to meet the ITC’s 

amphibian toxicity data needs for phenol, 4- 

(1,1,3,3-tetramethylbutyl)- and phenol, 4- 

nonyl-, branched. However, the ITC is 

leaving phenol, 4-(1,1,3,3-tetramethylbutyl)- 

and phenol, 4-nonyl-, branched on the 

Priority Testing List because it needs time to: 

• Determine if the existing fish 

reproductive effects data are sufficient to 

meet the ITC’s data needs. 

•Review the EPA’s Safer Detergents 

Stewardship Initiative (http://www.epa.gov/ 

dfe/pubs/projects/formulat/sdsi.htm). 

• Determine if phenol, 4-(1,1,3,3- 

tetramethylbutyl)- or phenol, 4-nonyl-, 

branched should be tested for avian 

reproductive effects. 

3. Tungsten compounds. Of the 22 

tungsten compounds added to the Priority 

Testing List in the 53rd ITC Report (Ref. 36) 

and 56th ITC Report (Ref. 2), 12 were 

removed in the 58th ITC Report (Ref. 3). At 

this time the ITC is removing 5 additional 

tungsten compounds from the Priority 

Testing List (See Table 4 of this unit.). 

TABLE 4.—TUNGSTEN COMPOUNDS

BEING REMOVED FROM THE PRIORITY

TESTING LIST

CAS No. Chemical name 

7783–03–1 Tungstate (WO4

2-), dihydrogen, (T-4)- 

7783–82–6 Tungsten fluoride (WF6), (OC6-11)- 

12028–48–

7 

Tungstate (W12(OH)2O386-), 

hexaammonium 

12036–22–

5 

Tungsten oxide (WO2) 

12138–09–

9 

Tungsten sulfide (WS2) 

The ITC is removing these five tungsten 

compounds from the Priority Testing List 

because production volume and worker 

numbers data submitted in response to the 

December 7, 2004 PAIR rule (Ref. 37) 

indicate low potential for occupational 

exposure. 

Table 5 of this unit lists the tungsten 

compounds remaining on the Priority Testing 

List. 

TABLE 5.—TUNGSTEN COMPOUNDS

REMAINING ON THE PRIORITY TESTING LIST

CAS No. Chemical name 

1314–35–8 Tungsten oxide (WO3) 

7440–33–7 Tungsten 

10213–10–

2 

Tungstate (WO4

2-), disodium, 

dihydrate, (T-4)- 

11120–25–

5 

Tungstate (W12(OH)2O4010-), 

decaammonium 

13472–45–

2 

Tungstate (WO4

2-), disodium, 

(T-4)- 

V. References 

1. EPA. 1998. Revisions to Reporting 

Regulations under TSCA Section 8(d). 

Federal Register (63 FR 15765, April 1, 1998) 

(FRL–5750–4). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

2. ITC. 2005. Fifty-Sixth Report of the ITC. 

Federal Register (70 FR 61520, October 24, 

2005) (FRL–7739–9). Available on-line at: 

http://www.epa.gov/fedrgstr. 

3. ITC. 2006. Fifty-Eighth Report of the 

ITC. Federal Register (70 FR 39187, July 11, 

2006) (FRL–8073–7). Available on-line at: 

http://www.epa.gov/fedrgstr. 

4. ITC. 1993. Thirty-First Report of the ITC. 

Federal Register (58 FR 26898, May 5, 1993) 

(FRL–4583–4). Available on-line at: http:// 

www.regulations.gov, EPA-HQ-OPPT-2006- 

0961. 

5. ITC. 1993. Thirty-Second Report of the 

ITC. Federal Register (58 FR 38490, July 16, 

1993) (FRL–4630–2). Available on-line at: 

http://www.regulations.gov, EPA-HQ-OPPT2006-0961. 

6. ITC. 1994. Thirty-Fifth Report of the ITC. 

Federal Register (59 FR 67596, December 29, 

1994) (FRL–4923–2). Available on-line at: 

http://www.regulations.gov, EPA-HQ-OPPT2006-0961. 

7. ITC. 1994. Thirty-Fourth Report of the 

ITC. Federal Register (59 FR 35720, July 13, 

1994) (FRL–4870–4). Available online at 

http://www.regulations.gov, EPA-HQ-OPPT2006-0961. 

8. ITC. 1995. Thirty-Sixth Report of the 

ITC. Federal Register (60 FR 42982, August 

17, 1995) (FRL–4965–6). Available on-line at: 

http://www.epa.gov/fedrgstr. 

9. ITC. 2000. Forty-Fifth Report of the ITC. 

Federal Register (65 FR 75544, December 1, 

2000) (FRL–6399–5). Available on-line at: 

http://www.epa.gov/fedrgstr. 

10. EPA. 1999. Proposed Test Rule for In 

Vitro Dermal Absorption Rate Testing of 

Certain Chemicals of Interest to Occupational 

Safety and Health Administration. Federal 

Register (64 FR 31074, June 9, 1999) (FRL–

5760–3). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

11. EPA. 2004. Final Test Rule for In Vitro 

Dermal Absorption Rate Testing of Certain 

Chemicals of Interest to Occupational Safety 

and Health Administration. Federal Register 

(69 FR 22402, April 26, 2004) (FRL–7312–2). 

Available on-line at: http://www.epa.gov/ 

fedrgstr. 

12. EPA. 2002 Reporting Notice; 2002. 

Partial Updating of TSCA Inventory Data 

Base; Production and Site Reports; Federal 

Register (67 FR 18615, April 16, 2002) (FRL–

6826–5). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

13. EPA. 1994. Partial Updating of TSCA 

Inventory Data Base; Production and Site 

Reports; Technical Amendment. Federal 

Register (59 FR 30652, June 14, 1994) (FRL–

4869–7). Available on-line at: http:// 

www.regulations.gov, EPA–HQ–OPPT–2006–

0961. 

14. EPA. 1998. Partial Updating of TSCA 

Inventory Data Base; Production and Site 

Reports; Technical Amendment. Federal 

Register (63 FR 459503, August 28, 1998) 

(FRL–6028–3). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

15. EPA. 2006. Preliminary Assessment 

Information Reporting; Addition of Certain 

Chemicals. Federal Register (71 FR 47122, 

August 16, 2006) (FRL–7764–9). Available 

on-line at: http://www.epa.gov/fedrgstr. 

16. EPA. 2006. Health and Safety Data 

Reporting; Addition of Certain Chemicals. 

Federal Register (71 FR 47130, August 16, 

2006) (FRL–7764–7). Available on-line at: 

http://www.epa.gov/fedrgstr. 

17. EPA. 2006. Withdrawal of Certain 

Chemicals from Preliminary Assessment 

Information Reporting and Health and Safety 

Data Reporting Rules. Federal Register (71 

FR 57439, September 29, 2006) (FRL–8096–

5). Available on-line at: http://www.epa.gov/ 

fedrgstr. 

18. ITC. 1995. Thirty-Seventh Report of the 

ITC. Federal Register (61 FR. 4188, February 

2, 1996) (FRL–4991–6). Available on-line at: 

http://www.epa.gov/fedrgstr. 

19. ITC. 1996. Thirty-Ninth Report of the 

ITC. Federal Register (62 FR 8578, February 

25, 1997) (FRL–5580–9). Available on-line at: 

http://www.epa.gov/fedrgstr. 

20. ITC. 1997. Forty-First Report of the ITC. 

Federal Register (63 FR 17658, April 9, 1998) 

(FRL–5773–5). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

21. ITC. 2000. Forty-Sixth Report of the 

ITC. Federal Register (65 FR 75552, 

December 1, 2000) (FRL–6594–7). Available 

on-line at: http://www.epa.gov/fedrgstr. 

22. ITC. 2000. Forty-Third Report of the 

ITC. Federal Register (65 FR 65234, October 

31, 2000) (FRL–6049–5). Available on-line at: 

http://www.epa.gov/fedrgstr. 

23. ITC. 2001. Forty-Eighth Report of the 

ITC. Federal Register (66 FR 51276, October 

5, 2001) (FRL–6786–7). Available on-line at: 

http://www.epa.gov/fedrgstr. 

24. EPA. 1986. Partial Updating of TSCA 

Inventory Data Base; Production and Site 

Reports. Federal Register (51 FR 21438, June 

12, 1986). Available on-line at: http:// 

www.regulations.gov, EPA–HQ–OPPT–2006–

0961. 

25. EPA. 1990. Partial Updating of TSCA 

Inventory Data Base; Production and Site 


rmajette on PROD1PC67 with NOTICES3
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Reports; Technical Amendment. Federal 

Register (55 FR 39586, September 27, 1990) 

(FRL–3770–4). Available on-line at: http:// 

www.regulations.gov, EPA–HQ–OPPT–2006–

0961. 

26. EPA. 1996. Preliminary Assessment 

Information and Health and Safety Data 

Reporting; Addition of Certain Chemicals. 

Federal Register (61 FR 7421, February 28, 

1996) (FRL–4996–9). Available on-line at: 

http://www.epa.gov/fedrgstr. 

27. EPA. 2000. Preliminary Assessment 

Information and Health and Safety Data 

Reporting; Addition of Certain Chemicals. 

Federal Register (65 FR 1548, January 11, 

2000) (FRL–5777–2). Available on-line at: 

http://www.epa.gov/fedrgstr. 

28. EPA. 2000. Preliminary Assessment 

Information and Health and Safety Data 

Reporting; Addition of Certain Chemicals. 

Federal Register (65 FR 41371, July 5, 2000) 

(FRL–6589–1). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

29. ITC. 2002. Fiftieth Report of the ITC. 

Federal Register (67 FR 49530, July 30, 2002) 

(FRL–7183–7). Available on-line at: http:// 

www.epa.gov/fedrgstr. 

30. ITC. 2003. Fifty-First Report of the ITC. 

Federal Register (68 FR 8976, February 26, 

2003) (FRL–7285–7). Available on-line at: 

http://www.epa.gov/fedrgstr. 

31. Charles Rivers Laboratories, Edinburgh, 

Scotland. Final Report: p-tert-butylphenol 

Two Generation Reproduction Study in Rats 

Study No. 493595 Report No. 24804. 

Unpublished report sponsored by SASOL 

GmbH (Germany) and SI Group-Switzerland 

GmbH (Formerly Schenectady Pratteln 

GmbH, Switzerland). February 2006. 

32. Dwyer, F.J.; Mayer, F.L.; Sappington, 

L.C.; Buckler, D.R.; Bridges, C.M.; Greer, I.E.; 

Hardesty, D.K.; Henke, C.E.; Ingersoll, C.G.; 

Kunz, J.L.; Whites, D.W.; Augspurger, T.; 

Mount, D.R.; Hattala, K.; and Neuderfer, G. 

2005. Assessing contaminant sensitivity of 

endangered and threatened aquatic species: 

Part I. Acute toxicity of five chemicals. 

Archives Environmental Contamination 

Toxicology. 48:143–154. 

33. Van Miller, J.P. Staples CA. 2005. 

Review of the potential environmental and 

human health-related hazards and risks from 

long-term exposure to p-tert-octylphenol. 

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11:319–351. 

34. Kloas, W.; Lutz, I.; Einspanier, R. 1999. 

Amphibians as a model to study endocrine 

disruptors: II. Estrogenic activity of 

environmental chemicals in vitro and in vivo. 

Science of the Total Environment. 225:59–68. 

35. Crump, D.; Lean, D.; and Trudeau, V.L. 

2002. Octylphenol and UV-B radiation alter 

larval development and hypothalamic gene 

expression in the Leopard Frog (Rana 

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36. ITC. 2004. Fifty-Third Report of the 

ITC. Federal Register (69 FR 2467, January 

15, 2004) (FRL–7335–2). Available on-line at: 

http://www.epa.gov/fedrgstr. 

37. EPA. 2004. Preliminary Assessment 

Information Reporting; Addition of Certain 

Chemicals. Federal Register (69 FR 70552, 

December 7, 2004) (FRL–7366–8). Available 

on-line at: http://www.epa.gov/fedrgstr. 

VI. The TSCA Interagency Testing 

Committee 

Statutory Organizations and Their 

Representatives 

Council on Environmental Quality 

Vacant 

Department of Commerce 

National Institute of Standards and 

Technology 

Dianne Poster, Member, Vice Chair 

National Oceanographic and 

AtmosphericAdministration 

Tony Pait, Member 

Environmental Protection Agency 

John Schaeffer, Member 

Gerry Brown, Alternate 

National Cancer Institute 

Alan Poland, Alternate 

National Institute of Environmental Health 

Sciences 

John Bucher, Member 

Scott Masten, Alternate 

National Institute for Occupational Safety 

and Health 

Dennis W. Lynch, Member 

Mark Toraason, Alternate 

National Science Foundation 

Cindy Lee, Member 

Marge Cavanaugh, Alternate 

Occupational Safety and Health 

Administration 

Maureen Ruskin, Member, Chair 

Thomas Nerad, Alternate 

Liaison Organizations and Their 

Representatives 

Agency for Toxic Substances and Disease 

Registry 

Daphne Moffett, Member 

Glenn D. Todd, Alternate 

Consumer Product Safety Commission 

Jacqueline Ferrante, Member 

Department of Agriculture 

Clifford P. Rice, Member 

Laura L. McConnell, Alternate 

Department of Defense 

Laurie Roszell, Member 

Department of the Interior 

Barnett A. Rattner, Member 

Food and Drug Administration 

Kirk Arvidson, Alternate 

Ronald F. Chanderbhan, Alternate 

National Library of Medicine 

Vera W. Hudson, Member 

National Toxicology Program 

NIEHS, FDA, and NIOSH, Members 

Technical Support Contractor 

Syracuse Research Corporation 

ITC Staff 

John D. Walker, Director 

Carol Savage, Administrative Assistant 

TSCA Interagency Testing Committee (7401), 

Office of Pollution Prevention and Toxics, 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, DC 

20460–0001; e-mail address: 

savage.carol@epa.gov; url: http:// 

www.epa.gov/opptintr/itc. 

[FR Doc. E7–837 Filed 1–19–07; 8:45 am] 

BILLING CODE 6560–50–S 


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