EX-4.21





 Exhibit 4.21 

DATED 17 DECEMBER 2020 
  

			
	(1)	  	MEREO BIOPHARMA GROUP PLC
		
	(2)	  	THE NOTEHOLDERS NAMED HEREIN

  
  

DEED OF CONSENT AND AMENDMENT 

RELATING TO A CONVERTIBLE LOAN NOTE 

INSTRUMENT DATED 3 JUNE 2020 












 CONTENTS 
  

					
	1	  	DEFINITIONS AND INTERPRETATION	  	3
			
	2	  	CONSENT	  	3
			
	3	  	AMENDMENT, WAIVER AND DELIVERY OF AMENDED NOTE INSTRUMENT	  	4
			
	4	  	CONTINUITY AND FURTHER ASSURANCE	  	4
			
	5	  	COSTS AND EXPENSES	  	4
			
	6	  	MISCELLANEOUS	  	4
			
	7	  	GOVERNING LAW	  	5
		
	SCHEDULE 1 AMENDED NOTE INSTRUMENT (MARKED CHANGES)	  	6
		
	SCHEDULE 2 AMENDED NOTE INSTRUMENT (CLEAN COPY)	  	7













 THIS DEED is dated 17 December 2020 and made between: 

 

	(1)	 MEREO BIOPHARMA GROUP PLC, incorporated and registered in England and Wales with company number 09481161
whose registered office is at 4th Floor, 1 Cavendish Place, London W1G 0QF, United Kingdom (the “Company”); 


  

	(2)	 ORBIMED PRIVATE INVESTMENTS VII, LP a Delaware limited partnership with office address at c/o
Corporation Service Company, 251 Little Falls Drive, Wilmington, DE 19808; 


  

	(3)	 ORBIMED PARTNERS MASTER FUND LIMITED, a Bermuda company with office address at c/o Conyers Corporate
Services (Bermuda) Limited, Clarendon House, 2 Church Street, Hamilton, HM 11 Bermuda; 


  

	(4)	 ORBIMED GENESIS MASTER FUND, L.P. Cayman Islands limited partnership with office address at c/o
Intertrust (Cayman) Ltd., 190 Elgin Avenue, George Town, Grand Cayman KY1- 9005, Cayman Islands (together with OrbiMed Private Investments VII, LP and OrbiMed Partners Master Fund Limited, “OrbiMed”); 



 

	(5)	 667, L.P. a Delaware limited partnership with office address at Baker Brothers Investments, 860
Washington St, 3rd Floor, New York, NY 10014; 


  

	(6)	 BAKER BROTHERS LIFE SCIENCES, L.P. a Delaware limited partnership with office address at Baker Brothers
Investments, 860 Washington St, 3rd Floor, New York, NY 10014 (together with 667, L.P., “Baker Brothers”); 


  

	(7)	 VIVO CAPITAL FUND IX, L.P. a Delaware partnership with office address C/O Vivo Capital LLC, 192 Lytton
Avenue, Palo Alto, CA 94301; 


  

	(8)	 VIVO OPPORTUNITY FUND, L.P. a Delaware partnership with office address C/O Vivo Capital LLC, 192 Lytton
Avenue, Palo Alto, CA 94301 (together with Vivo Capital Fund IX L.P., “Vivo”); 


  

	(9)	 BOXER CAPITAL, LLC, a Delaware company with office address 11682 El Camino Real, Suite 320, San Diego,
CA 92130; and 


  

	(10)	 MVA INVESTORS, LLC, a Delaware company with office address 11682 El Camino Real, Suite 320, San Diego,
CA 92130 (together with Boxer Capital LLC, “Tavistock”), (OrbiMed, Baker Brothers, Vivo and Tavistock together, the “Noteholders”). 



WHEREAS: 
  

	(a)	 We refer to the convertible loan note instrument originally dated 3 June 2020 and as amended on
9 June 2020 pursuant to which the Company constituted certain unsecured convertible loan notes of £1 principal amount each (the “Note Instrument”), the defined terms of which shall bear the same meaning in this Deed
unless a contrary intention appears. 


  

	(b)	 As a result of an increasingly smaller proportion of trading in the Company’s shares being conducted on
the Alternative Investment Market (“AIM”) operated by the London Stock Exchange, and the duplicative costs and staff time involved in complying with both the AIM Rules for Companies and the NASDAQ market rules, the Company is
intending to cancel the 



  
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admision of its Ordinary Shares to trading on AIM from with effect from 18 December 2020 (the “Delisting”). Following the Delisting, the only listing maintained by the Company will
be that of American depositary receipts on NASDAQ, the tradeable entitlement representing American Depositary Shares (“ADSs”), each of which such ADS represents five Ordinary Shares shares of £.003 in the capital of the Company.


  

	(c)	 If the Note Instrument is not amended as contemplated by this Deed then, following the Delisting, upon a
conversion of Notes under the Note Instrument, the Company’s legal obligations in respect of the issue of Shares to a converting Noteholder would be satisfied by the delivery of the relevant number of unlisted Ordinary Shares to which such
converting Noteholder is entitled. There would be no obligation on the Company to either (i) obtain an alternative listing of the Company’s Ordinary Shares; or (ii) to deliver ADSs upon a conversion of the Notes.



  

	(d)	 Given the limited liquidity offered by unlisted Ordinary Shares compared to AIM-listed Ordinary Shares, the
Company intends to amend the terms of the Note Instrument to allow for conversion of the Notes to result in the direct issue of ADSs to a Noteholder, without the need for such Noteholder to first be issued with unlisted Ordinary Shares. This
mechanism for conversion of Notes into ADSs will operate as follows: 


  

	 	(i)	 when a Noteholder serves a notice in writing to the Company that it wishes to convert outstanding Notes (a
“Conversion Notice”) pursuant to Part 2 of Schedule 2 of the Note Instrument, they may also send the Company an ADS Issuance and Delivery Instruction (the form of which is included at Part 4 to Schedule 2 of the Amended Note
Instrument) if they wish for such Ordinary Shares to be delivered in the form of ADSs; 


  

	 	(ii)	 on the relevant Conversion Date, in respect of any Noteholder who wishes to receive ADSs and who has also sent
a ADS Issuance and Delivery Instruction (the form of which is set out at Part 4 of Schedule 2 to the Amended Note Instrument), the Company issues the relevant number of unlisted Ordinary Shares as is specified in the Conversion Notice to the
custodian of the Depositary (as defined below); 


  

	 	(iii)	 the custodian confirms to the Depositary that it has received the relevant number of Ordinary Shares specified
in the Conversion Notice; and 


  

	 	(iv)	 upon receipt of such confirmation, the Depositary issues the relevant number of ADSs to the DTC Participant
Account details specified in the ADS Issuance and Delivery Instruction. 


  

	(e)	 By this deed, the Company seeks the Noteholder Majority Consent required pursuant to Clause 12
(Variation) to adopt the Amended Note Instrument in the form attached at Schedule 2 hereto so as to effect the amendments outlined at Recitals (a)-(d) above and detailed in the form of the Amended Note Instrument. 



  
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 IT IS AGREED as follows: 
  

	1	 DEFINITIONS AND INTERPRETATION 



 

	1.1	 Definitions 



In this Deed: 
  

			
	ADS	  	has the meaning given in Recital (b);
		
	AIM	  	has the meaning given in Recital (b);
		
	Amended Note Instrument	  	means the Note Instrument, as amended by this Deed, in the form attached hereto at Schedule 1;
		
	Conversion Notice	  	has the meaning given in Recital (d);
		
	Delisting	  	has the meaning given in Recital (b);
		
	Depositary	  	means the Depositary engaged by the Company for the issuance and transfer of ADSs, being Citibank N.A. as at the Effective Date;
		
	Effective Date	  	the date of this Deed; and
		
	Note Instrument	  	has the meaning given in Recital (a).


  

	1.2	 Interpretation 



The principles of construction set out in the Note Instrument shall have effect as if set out in this Deed. 

 

	1.3	 Clauses 



In this Deed any reference to a “Clause” or a “Schedule” is, unless the context otherwise requires, a reference to a Clause
in or a Schedule to this Deed. 
  

	1.4	 Third party rights 



A Person who is not a party to this Deed has no rights under the Contracts (Rights of Third Parties) Act 1999 to enforce or enjoy the benefit
of any term of this Deed. 
  

	2	 CONSENT 



For all purposes pursuant to the Note Instrument (in particular clause 12.1), the Noteholders hereby consent as of the Effective Date to the
adoption of the Amended Note Instrument by the Company on the terms set out in this Deed. 

  
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	3	 AMENDMENT, WAIVER AND DELIVERY OF AMENDED NOTE INSTRUMENT 



 

	3.1	 Amendment 



With effect from the Effective Date, the Note Instrument shall be amended so as to include all the changes marked within the version of the
Note Instrument as set out in Schedule 1 (Amended Note Instrument). The amendment of the Note Instrument is without prejudice to the rights of any of the parties to the Note Instrument in respect of matters that arose prior to the Effective Date.
For the avoidance of doubt and for the future reference of the Noteholders, the Company, their successors in title and any other persons with an interest in the Notes or the terms of the Note Instrument (if any), Schedule 2 attaches a complete and
clean copy of the Amended Note Instrument which incorporates the changes implemented pursuant to this Deed. 
  

	3.2	 Waiver 



The adoption of the Amended Note Instrument by the Company constitutes a variation for the purposes of clause 12.1 of the Note Instrument and
is binding on all Noteholders. 
  

	3.3	 Delivery of Amended Note Instrument 



No later than 5 Business Days after the Effective Date, the Company shall dispatch an executed copy of the Amended Note Instrument to each
Noteholder. 
  

	4	 CONTINUITY AND FURTHER ASSURANCE 



 

	4.1	 Continuing obligations 



The provisions of the Note Instrument shall, save as amended by this Deed, continue in full force and effect and any Notes in issue shall, from
the Effective Date, be construed in accordance with the terms of the Amended Note Instrument. 
  

	4.2	 Further assurance 



The Company and each of the Noteholders, shall, at the request of the Company or the Noteholder Majority (as the case may be) and at their own
expense, do all such acts and things necessary to give effect to the amendments effected or to be effected pursuant to this Deed. 
  

	5	 COSTS AND EXPENSES 



Each Party shall be responsible for all costs and expenses (including but not limited to legal fees) it incurs in connection with the
negotiation, preparation, printing and execution of this Deed and any other documents referred to in this Deed. 
  

	6	 MISCELLANEOUS 



 

	6.1	 Incorporation of terms 



The provisions of clause 14 (Notices) of the Note Instrument shall be incorporated into this Deed as if set out in full in this Deed and as if
references in that clause to “this Instrument” are references to this Deed. 

  
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	6.2	 Counterparts 



This Deed may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single
copy of this Deed. 
  

	7	 GOVERNING LAW 



This Deed and any non-contractual obligations arising out of or in connection with it are governed by English law. 

This Deed has been entered into and delivered on the date stated at the beginning of this Deed. 

  
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 SCHEDULE 1 AMENDED NOTE INSTRUMENT (MARKED CHANGES) 

  
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 THIS INSTRUMENT AND THE SECURITIES ISSUABLE UPON THE CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”). THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT OR PURSUANT TO AN APPLICABLE
EXEMPTION THEREFROM. 

DATED                 JUNEDECEMBER 2020 

AMENDED
 CONVERTIBLE LOAN NOTE INSTRUMENT
DATED 3
JUNE 2020
 
 RELATING TO 

MEREO BIOPHARMA GROUP PLC 

  
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 CONTENTS 
  

							
	 1.
	 	Interpretation	  	 	4	 
			
	 2.
	 	Amount and description of notes	  	 	11	 
			
	 3.
	 	Status of notes	  	 	12	 
			
	 4.
	 	Use of Proceeds	  	 	13	 
			
	 5.
	 	Repayment of Notes	  	 	13	 
			
	 6.
	 	Interest	  	 	13	 
			
	 7.
	 	Certificates	  	 	14	 
			
	 8.
	 	The Register	  	 	14	 
			
	 9.
	 	Notes not to be quoted	  	 	15	 
			
	 10.
	 	Set-off	  	 	15	 
			
	 11.
	 	Meetings of Noteholders	  	 	16	 
			
	 12.
	 	Variation	  	 	16	 
			
	 13.
	 	Enforcement and third party rights	  	 	16	 
			
	 14.
	 	Notices	  	 	17	 
			
	 15.
	 	Governing law and jurisdiction	  	 	17	 
		
	 SCHEDULE 1
	  	 	1618	 
			
	 Part 1.
	 	 -Form of Tranche 1 Note Certificate
	  	 	1618	 
			
	 Part 2.
	 	 -Form of Tranche 2 Note Certificate
	  	 	1820	 
			
	 Part 3.
	 	-Form of Tranche 3 Note Certificate	  	 	2022	 
		
	 SCHEDULE 2 THE CONDITIONS
	  	 	2224	 
			
	 Part 1.
	 	 Interest, repayment and redemption
	  	 	2224	 
			
	 1.
	 	 Interest
	  	 	2224	 
			
	 2.
	 	 Repayment of principal
	  	 	2325	 
			
	 3.
	 	 Time of payment
	  	 	2527	 
			
	 4.
	 	 Redemption
	  	 	2527	 
			
	 5.
	 	 Events of Default
	  	 	3133	 
			
	 6.
	 	 Action following Event of Default
	  	 	3234	 
			
	 7.
	 	 Taxation
	  	 	3235	 
			
	 Part 2.
	 	 Conversion
	  	 	3436	 
			
	 1.
	 	 Conversion
	  	 	3436	 
			
	 2.
	 	 Procedures on conversion
	  	 	3538	 
			
	 Part 3.
	 	Transfer provisions, Undertakings and other matters	  	 	3740	 
			
	
Part 4.
	 	ADS Issuance and Delivery Instruction	  	 	46	 
		
	 SCHEDULE 3 MEETINGS OF
THE NOTEHOLDERS
	  	 	4349	 


  
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 THIS INSTRUMENT is made as a deed poll on 3 June 2020 and as amended on 9 June 2020 and December 2020. 
 BY 

MEREO BIOPHARMA GROUP PLC incorporated and registered in England and Wales with company number 09481161 whose registered office is at 4th Floor, 1
Cavendish Place, London W1G 0QF, United Kingdom (the “Company”). 
 WHEREAS: 

 

	A.	 TheOn 3 June 2020
the Company is enteringentered into certain financing transactions on or
around the date hereof, pursuant to which OrbiMed Partners Master Fund Limited, OrbiMed Genesis Master Fund L.P. and OrbiMed Private Investments VII, LP (the “Lead Investors”) and certain other investors (the
“Investors”) shall be subscribingsubscribed for the following securities of the Company:
(x) a unit (referred to for convenience as “Ordinary Units”), consisting of (i) one ordinary share of the Company with a nominal value of £0.003 per share (such class of shares, the “Ordinary
Shares,” and all such shares to be issued to the Purchasers, the “Shares”) together with (ii) one warrant to subscribe for 0.50 Ordinary Shares (all such warrants to be issued to the Purchasers, the “Ordinary
Warrants”), at a purchase price of £0.174 per Unit and (y) a unit (referred to for convenience as the “Convertible Units”) consisting of (i) one Note together with (ii) warrants to subscribe for a number of
Ordinary Shares equal to 0.5 times the number of Ordinary Shares issuable upon conversion of each Note (all such warrants to be issued to the Purchasers, the “Note Warrants” and together with the Ordinary Warrants (the
“Warrants”) (the issuance of the foregoing Ordinary Units and Convertible Units collectively , the “Transaction”). 


  

	B.	 By exercise of the powers conferred on them by the Articles, the Directors of the Company have, by a
resolution passed on 1 June 2020, resolved to create, and to constitute the Notes hereunder. 


  

	C.	 This Instrument constitutes the Notes. 



 

	D.	 The Company and its subsidiaries are parties to an existing senior secured loan agreement in the
principal amount of £20,455,000 with Silicon Valley Bank (as lender) (“SVB”) and Kreos Capital V (UK) Limited (as lender, agent and security agent) (“Kreos”), dated 28 September 2018 (as updated and
amended from time to time) (the “Senior Loan”). 



  
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	E.	 The Notes created hereunder shall be subordinated to the Senior Loan by entry into a separate
subordination deed between the Noteholders, Kreos and SVB on or around the date hereof (the “Subordination Agreement”). 



AGREED TERMS 
  

	1.	 INTERPRETATION 



 

	1.1	 The definitions and rules of interpretation in this clause apply in this Instrument. 



 

	1.2	 Acceleration Date: has the meaning given in paragraph 4 of Part 1 of Schedule 2. 



ADS: has the meaning given in the Securities Purchase Agreement. 

ADS Exchange
Ratio: means the ratio applicable to the exchange of Ordinary Shares for ADSs from time to time, currently being a ratio of 5 Ordinary Shares for each ADS. 

Affiliate: means a person that owns or controls directly or indirectly another person, any person that controls or is controlled by or
is under common control with the person, including, without limitation, any subsidiaries, and any of that person’s general or limited partners, senior executive officers, directors and, for any person that is a limited liability company, that
person’s managers and members or any venture capital fund or registered investment company now or hereafter existing that is controlled by one or more general partners or managing members or investment advisor of, or shares the same management
company or investors advisor (or member thereof) with, such person. 
 Alternative Warrant Conversion Notice: has the meaning given in
the Securities Purchase Agreement. 
 Articles: means the articles of association of the Company, as amended or superseded. 

Business Day: means any day other than Saturday, Sunday or federal legal holiday in the United States of America, or public holiday or
bank holiday in the United Kingdom. 
 Certificate: means a Tranche 1 Note Certificate, a Tranche 2 Note Certificate or a Tranche 3
Note Certificate, as applicable. 

  
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 Change of Control: means, (a) in one transaction or a series of related
transactions, a person or one or more persons acting in concert, acquiring (i) all (or substantially all) of the share capital or assets of the Company, or (ii) more than fifty percent (50%) of the outstanding equity or other securities of
the Company; or (b) any merger, consolidation, reorganisation, or business combination as a result of which the majority equity or other security holders of the Company immediately preceding such transaction (s) hold less than fifty
percent (50%) of the outstanding voting power, respectively, of the ultimate company or entity resulting from such transaction(s) immediately after consummation of such transaction. In the foregoing case, “acting in concert” means a
group of persons who, pursuant to an agreement or understanding (whether formal or informal), actively co-operate, through the acquisition and/or ownership of voting shares in the Company, to obtain or consolidate control (directly or indirectly) of
the Company provided that the persons voting in the same or consistent manner at any general meeting of the Company will not be considered to be acting in concert by virtue only of exercising their votes in such manner. 

Change of Control Payment: has the meaning given in paragraph 4.12 of Part 1 of Schedule 2. 

Closing Price: means: (i) if at the relevant time the Ordinary Shares continue to be admitted to trading on AIM, the most recently
reported closing price of one Ordinary Share on AIM; or (ii) if at the relevant time the Shares are no longer admitted to trading on AIM, the implied price of one Ordinary Share in pounds sterling by reference to the most recently reported
closing price of an ADS on Nasdaq. 
 Conditions: means the conditions attaching to the Notes, as set out in Schedule 2 (as amended
from time to time in accordance with this Instrument). 
 Conversion Date: means (i) in the case of Tranche 1 Notes being
converted automatically following Shareholder Approval pursuant to the provisions of paragraph 1.2 of Part 2 of Schedule 2, the date on which such Shareholder Approval is granted; and/or (ii), in the case of an Uplift Notice or Pay Down Notice, the
date specified in such notice; and/or (iii) in all other cases, the date falling 5 Business Days after service of the Conversion Notice. 

Conversion Notice: means a notice in writing served by a Noteholder to the Company to convert all or, if the Ownership Limit applies,
some of its outstanding Notes. 
 Default Rate: means the Tranche 1 Default Rate, Tranche 2 Default Rate or Tranche 3 Default Rate (as
applicable). 

Depositary:
 has the meaning given in the Securities Purchase Agreement. 
 Directors:
means the board of directors of the Company, or a duly authorised committee of that board, for the time being. 
 Effective Date:
means the date of this Deed. 

  
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 Event of Default: means any of the events set out in paragraph 5 of Part 1 of
Schedule 2. 
 Existing Indebtedness: means any indebtedness incurred by a Group Company and outstanding on or prior to the Effective
Date (which for the avoidance of doubt shall include indebtedness pursuant to the Senior Loan and the Novartis Loan Note). 
 Group
Company: means each of the Company and its subsidiaries. 
 Interest Rate: has the meaning given in paragraph 1 of Part 1 of
Schedule 2. 
 Kreos: has the meaning given in the recitals of this Instrument. 

Lead Investors: has the meaning given in the recitals of this Instrument. 

Nasdaq: means the Nasdaq Global Market or the Nasdaq Capital Market (as applicable). 

Notes: means the Tranche 1 Notes, the Tranche 2 Notes or the Tranche 3 Notes, as applicable. 

Noteholder: means a person for the time being entered in the Register as holder of any Notes. 

Noteholder Majority: means Noteholders holding more than 50% of the principal amount of all outstanding Notes. 

Noteholder Majority Consent: means the consent of a Noteholder Majority provided either at a meeting of Noteholders or in writing, in
each case in accordance with the requirements of Schedule 3. 
 Novartis: means Novartis Pharma AG, a company incorporated under the
laws of Switzerland. 
 Novartis Loan Note: means the convertible loan note originally issued by the Company to Novartis in the
principal amount of £3,841,479 on 8 February 2020. 
 Ordinary Shares: means the ordinary shares of £0.003 each
in the capital of the Company, which have the rights set out in the Articles. 
 Original Warrantholder: has the meaning given in the
Securities Purchase Agreement. 
 Ownership Limit: has the meaning given in paragraph 1.2 of Part 2 of Schedule 2. 

Pay Down Issue: has the meaning given in paragraph 4.7 of Part 1 of Schedule 2. 

Pay Down Notice: has the meaning given in paragraph 4.7 of Part 1 of Schedule 2. 

Pay Down Securities: has the meaning given in paragraph 4.7 of Part 1 of Schedule 2. 

  
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 Pay Down Reduction Amount: has the meaning given in paragraph 4.8 of Part 1 of
Schedule 2. 
 Qualifying Noteholder: means any Noteholder holding Notes with a principal amount of £6,004,803.84 million or greater. 

Redemption Date: has the meaning given in paragraph 4.1 of Part 1 of Schedule 2. 

Redemption Notice: has the meaning given in paragraph 4.13 of Part 1 of Schedule 2. 

Register: means a register of Noteholders referred to in, and kept and maintained in accordance with, clause 8. 

Registered Office: means the registered office of the Company from time to time. 

Securities Purchase Agreement: means the agreement governing the purchase of Ordinary Shares comprising the Transaction among, inter
alios, the Company, the Lead Investors and the other Investors party thereto, dated on or around the date hereof. 
 Senior
Lenders: means SVB and Kreos (and each of them individually, a “Senior Lender”) and/or their respective successors in title. 

Senior Loan: has the meaning given in the recitals of this Instrument. 

Shareholder Approval: has the meaning given in the Securities Purchase Agreement. 

Shareholders Meeting: has the meaning given in the Securities Purchase Agreement. 

Shares: has the meaning given in the recitals of this Instrument. 

Subordination Agreement: has the meaning given in the recitals of this Instrument. 

SVB: has the meaning given in the recitals of this Instrument. 

Tranche 1 Conversion Price: £0.174 per Ordinary Share, subject to adjustment as set forth in Part 3 of Schedule 2. 

Tranche 2 Conversion Price: £0.348 per Ordinary Share, subject to adjustment as set forth in Part 3 of Schedule 2. 

Tranche 1 Default Rate: has the meaning given in paragraph 1.1 of Part 1 of Schedule 2. 

Tranche 2 Default Rate: has the meaning given in paragraph 1.2 of Part 1 of Schedule 2. 

Tranche 3 Default Rate: has the meaning given in paragraph 1.3 of Part 1 of Schedule 2. 

  
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 Tranche 1 Extension Option: has the meaning given in paragraph 2.3 of Part 1 of
Schedule 2. 
 Tranche 1 Extension Notice: has the meaning given in paragraph 2.3 of Part 1 of Schedule 2. 

Tranche 2 Extension Option: has the meaning given in paragraph 2.5 of Part 1 of Schedule 2. 

Tranche 2 Extension Notice: has the meaning given in paragraph 2.5 of Part 1 of Schedule 2. 

Tranche 3 Extension Option: has the meaning given in paragraph 2.7 of Part 1 of Schedule 2. 

Tranche 3 Extension Notice: has the meaning given in paragraph 2.7 of Part 1 of Schedule 2. 

Tranche 1 Maturity Date: means 3 June 2023 or, in respect of any Tranche 1 Notes held by a Qualifying Noteholder, such later date
as may be applicable following exercise of the Tranche 1 Extension Option. 
 Tranche 2 Maturity Date: means the date falling three
years from the date of issue of such Tranche 2 Notes, or in respect of any Tranche 2 Notes held by a Qualifying Noteholder, such later date as may be applicable following exercise of the Tranche 2 Extension Option. 

Tranche 3 Maturity Date: means 3 June 2025 or, in respect of any Tranche 3 Notes held by a Qualifying Noteholder, such later date
as may be applicable following exercise of the Tranche 3 Extension Option and acceptance by the Company of the same. 
 Tranche 1 Note
Certificate: a certificate for Tranche 1 Notes in the form (or substantially in the form) set out in Part 1 of Schedule 1. 
 Tranche
2 Note Certificate: a certificate for Tranche 2 Notes in the form (or substantially in the form) set out in Part 2 of Schedule 1. 

Tranche 3 Note Certificate: a certificate for Tranche 3 Notes in the form (or substantially in the form) set out in Part 3 of Schedule
1. 
 Tranche 1 Noteholder: means a Noteholder holding Tranche 1 Notes.  

Tranche 2 Noteholder: means a Noteholder holding Tranche 2 Notes.  

Tranche 3 Noteholder: means a Noteholder holding Tranche 3 Notes. 

Tranche 1 Notes: up to £40,533,671 in aggregate unsecured convertible loan notes of £1 principal amount each, maturing on
the Tranche 1 Maturity Date constituted by this Instrument or, as the case may be, the principal amount of such loan notes for the time being issued and outstanding, and principal amount shall be construed accordingly. 

  
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 Tranche 2 Notes: up to £40,032,025 in aggregate unsecured convertible loan
notes of £1 principal amount each, maturing on the Tranche 2 Maturity Date constituted by this Instrument or, as the case may be, the principal amount of such loan notes for the time being issued and outstanding, and principal amount
shall be construed accordingly. 
 Tranche 3 Notes: up to £56,044,831 in aggregate unsecured loan notes of £1 principal
amount each, maturing on the Tranche 3 Maturity Date constituted by this Instrument or, as the case may be, the principal amount of such loan notes for the time being issued and outstanding, and principal amount shall be construed
accordingly. 
 Transaction: has the meaning given in the recitals of this Instrument. 

Uplift Allocation Notice: has the meaning given in paragraph 4.3 of part 1 of Schedule 2. 

Uplift Reduction Amount: has the meaning given in paragraph 4.4 of part 1 of Schedule 2. 

Uplift Securities: has the meaning given in paragraph 4.3 of part 1 of Schedule 2. 

Warrant: has the meaning given in the recitals of this Instrument. 

Warrant Instrument: means the instrument constituting the Warrants dated on or about the Effective Date. 

 

	1.3	 Clause, Schedule and paragraph headings shall not affect the interpretation of this Instrument.



  

	1.4	 References to clauses and Schedules are to the clauses of and Schedules to this Instrument and references to
paragraphs are to paragraphs of the relevant Schedule. 


  

	1.5	 The Schedules (including, for the avoidance of doubt, the Conditions) form part of this Instrument and shall
have effect as if set out in full in the body of this Instrument. Any reference to this Instrument includes the Schedules. 


  

	1.6	 A reference to this Instrument, the Conditions or to any other agreement or document referred to
in this Instrument or the Conditions is a reference to this Instrument (which shall include the Conditions), the Conditions or such other agreement or document as varied or novated in accordance with their terms from time to time.




  
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	1.7	 Unless the context otherwise requires, words in the singular shall include the plural and in the plural shall
include the singular. 


  

	1.8	 Unless the context otherwise requires, a reference to one gender shall include a reference to the other
genders. 


  

	1.9	 A person includes a natural person, corporate or unincorporated body (whether or not having separate
legal personality) and that person’s personal representatives, successors and permitted assigns. 


  

	1.10	 A reference to a company shall include any company, corporation or other body corporate, wherever and
however incorporated or established. 


  

	1.11	 A reference to a holding company or a subsidiary means a holding company or a subsidiary (as the
case may be) as defined in section 1159 of the Companies Act 2006. 


  

	1.12	 A reference to writing or written includes fax but not e-mail (unless otherwise expressly
provided in this Instrument). 


  

	1.13	 Any words following the terms including, include, in particular, for example or any
similar expression shall be construed as illustrative and shall not limit the sense of the words, description, definition, phrase or term preceding those terms. 



 

	1.14	 Where the context permits, other and otherwise are illustrative and shall not limit the sense of
the words preceding them. 


  

	1.15	 A reference to a statute or statutory provision is a reference to it as amended, extended or re-enacted from
time to time. 


  

	1.16	 A reference to a statute or statutory provision shall include all subordinate legislation made from time to
time under that statute or statutory provision. 


  

	1.17	 Any obligation on a person not to do something includes an obligation not to allow that thing to be done.



  

	1.18	 A reference in this Instrument to: 



  
 10 














	 	(a)	 any Notes being outstanding means such Notes as are in issue, not redeemed, not converted and not
cancelled at the relevant time; 


  

	 	(b)	 the assets of any person shall be construed as a reference to all or any part of its business,
undertaking, property, assets, revenues (including any right to receive revenues) and uncalled capital; 


  

	 	(c)	 indebtedness shall be construed as a reference to any obligation for the payment or repayment of money,
whether as principal or as surety and whether present or future, actual or contingent; 


  

	 	(d)	 repayment includes redemption and vice versa and the words repay, redeem, repayable, redeemed and
repaid shall be construed accordingly; 


  

	 	(e)	 $ or USD denotes the lawful currency of the United States of America; 



 

	 	(f)	 £ or sterling denotes the lawful currency of the United Kingdom; and 



 

	 	(g)	 tax shall be construed so as to include any present and future tax, levy, impost, deduction,
withholding, duty or other charge of a similar nature (including, without limitation, any penalty or interest payable in connection with any failure to pay or any delay in paying any of the same). 



 

	1.19	 Unless the context otherwise requires, a reference to the Notes includes a reference to all and/or any
of the Notes. 


  

	2.	 AMOUNT AND DESCRIPTION OF NOTES



  

	2.1	 The aggregate principal amount of the Tranche 1 Notes is limited to £40,533,671. 



 

	2.2	 The aggregate principal amount of the Tranche 2 Notes is limited to £40,032,025. 



 

	2.3	 The aggregate principal amount of the Tranche 3 Notes is limited to £56,044,831. 



 

	2.4	 The Tranche 1 Notes shall be known as the unsecured convertible loan notes due 2023 and shall be issued by the
Company in integral multiples of £1. 


  

	2.5	 The Tranche 2 Notes shall be known as the unsecured convertible loan notes due 2026 and shall be issued by the
Company in integral multiples of £1. 


  

	2.6	 The Tranche 3 Notes shall be known as the unsecured loan notes due 2025 and shall be issued by the Company in
integral multiples of £1. 



  
 11 














	3.	 STATUS OF NOTES 



 

	3.1	 The Notes when issued and outstanding shall rank pari passu, equally and rateably, without discrimination or
preference among themselves and as unsecured obligations of the Company. 


  

	3.2	 The Notes shall be issued and held subject to and with the benefit of the provisions of this Instrument
(including the Conditions). All such provisions shall be binding on the Company and the Noteholders and all persons claiming through or under them respectively and shall enure for the benefit of all Noteholders. 



 

	3.3	 No Notes shall be issued or deemed issued pursuant to this Instrument until Closing (as defined in the
Securities Purchase Agreement) has occurred in accordance with the terms and conditions of the Securities Purchase Agreement. 


  

	3.4	 No Tranche 2 Notes shall be issued to any person who is not a Qualifying Noteholder and has not served upon the
Company an Optional Warrant Conversion Notice (as defined in the Securities Purchase Agreement) in accordance with the provisions of section 5(h)(ii) of the Securities Purchase Agreement. 



 

	3.5	 Any Qualifying Noteholder who delivers an Optional Warrant Conversion Notice (as defined in the Securities
Purchase Agreement) in accordance with the provisions of Clause section 5(h)(ii) of the Securities Purchase Agreement shall have the subscription monies paid to the Company thereunder applied towards the subscription price for Tranche 2 Notes (in
the face amount of £1 for each Tranche 2 Note issued) in accordance with section 5(h)(ii) of the Securities Purchase Agreement. The subscription price in respect of all Warrants subject to the Optional Warrant Conversion Notice shall be
aggregated for purposes of determining the number of Tranche 2 Notes issued, provided that no Tranche 2 Notes shall be issued for any part payment towards a Tranche 2 Note and after aggregation of all such amounts, any remaining fractional sums
pursuant to an Optional Warrant Conversion Notice shall be discounted when calculating the number of Tranche 2 Notes to be issued. 


  

	3.6	 No Tranche 3 Notes shall be issued to any person if the Shareholder Approval is obtained on or before
7 August, 2020. 



  
 12 














	3.7	 If the Shareholder Approval is not obtained on or before 7 August, 2020, the Company shall deliver Tranche
3 Notes (in the face amount of £1 for each Tranche 3 Note issued) to each Original Warrantholder that delivers an Alternative Warrant Conversion Notice in accordance with section 5(i)(ii) of the Securities Purchase Agreement, within five
(5) Business Days after the surrender by the holder of the certificate representing the Warrant and the delivery of the Alternative Warrant Conversion Notice. 



 

	3.8	 For so long as the Senior Loan remains outstanding, no Notes shall be issued or deemed issued to any person
pursuant to this Instrument unless such person has first executed the Subordination Agreement or a deed of adherence to the Subordination Agreement (pursuant to which such person becomes bound by the terms of the Subordination Agreement) and
provided a copy of such executed document to the Company and the Senior Lenders. 


  

	4.	 USE OF PROCEEDS 



 

	4.1	 The proceeds of all subscriptions for the Notes shall be used in accordance with the terms and conditions of
Section 5(j) of the Securities Purchase Agreement. 


  

	4.2	 No part of the proceeds of any subscription for the Notes shall be used by the Company to make any dividend or
distribution to any shareholder in the Company, or for the repurchase of Ordinary Shares. 


  

	5.	 REPAYMENT OF NOTES 



 

	5.1	 The Notes shall be repaid in accordance with Part 1 of Schedule 2. 



 

	5.2	 All Notes repaid by the Company shall be automatically and immediately cancelled and shall not be reissued.



  

	6.	 INTEREST 



Until the Notes are repaid by the Company or converted into Ordinary Shares, in each case in accordance with the provisions of this Instrument,
interest shall accrue and be paid on the principal amount of the Notes outstanding at the rate and in the manner provided in Part 1 of Schedule 2. 

  
 13 














	7.	 CERTIFICATES 



 

	7.1	 Each Noteholder (or the joint holders of any Notes) shall be entitled to receive, without charge, one Tranche 1
Note Certificate and/or Tranche 2 Note Certificate and/or Tranche 3 Note Certificate (as applicable) for the Tranche 1 Notes and/or Tranche 2 Notes and/or Tranche 3 Notes registered in his (or their) names. 



 

	7.2	 Where any Notes are held jointly, the Company shall not be bound to issue more than one Certificate in respect
of such Notes and delivery of a Certificate to the person who is first named in the Register as Noteholder shall be sufficient delivery to all joint holders of such Notes. 



 

	7.3	 Each Certificate shall: 



 

	 	(a)	 bear a denoting number; 



 

	 	(b)	 indicate whether it relates to Tranche 1 Notes, Tranche 2 Notes, or Tranche 3 Notes; 



 

	 	(c)	 be issued and executed by the Company as a deed in the form (or substantially in the form) set out in Part 1 of
Schedule 1, Part 2 of Schedule 1 or Part 3 of Schedule 1 (as applicable); and 


  

	 	(d)	 have the Conditions endorsed on or attached to it. 



 

	7.4	 In the case of repayment or transfer of part only of a Noteholder’s Notes, the Certificate(s) in respect
of such Notes shall be either: 


  

	 	(a)	 endorsed with a memorandum of the nominal amount of the Notes so redeemed or transferred and the date of such
repayment or transfer; or 


  

	 	(b)	 cancelled and (without charge) replaced by a new Certificate for the balance of the principal amount of the
Notes not then repaid or transferred. 


  

	8.	 THE REGISTER 



 

	8.1	 The Company shall keep and maintain the Register at the Registered Office or (subject always to the provisions
of section 743 of the Act) at such other place as the Company may from time to time appoint for this purpose and notify to the Noteholders. 


  

	8.2	 There shall be entered in the Register: 



  
 14 














	 	(a)	 the names and addresses of the Noteholders for the time being; 



 

	 	(b)	 the principal amount of the Notes held by each Noteholder; 



 

	 	(c)	 whether the Notes held by each Noteholder are Tranche 1 Notes, Tranche 2 Notes or Tranche 3 Notes;



  

	 	(d)	 the date of issue of each of the Notes and the date on which the name of each Noteholder is entered in the
Register in respect of the Notes registered in his name; 


  

	 	(e)	 the serial number of each Certificate issued and the date of its issue; and 



 

	 	(f)	 the date(s) of all transfers and changes of ownership of any of the Notes. 



 

	8.3	 The Company shall promptly amend the Register to record any change to the name or address of a Noteholder that
is notified in writing to the Company by that Noteholder. 


  

	8.4	 The Noteholders or any of them, or any person authorised by a Noteholder, shall be at liberty at all reasonable
times during office hours to inspect the Register and to take copies of or extracts from it or any part of it. 


  

	8.5	 Every Noteholder shall be recognised by the Company as entitled to his Notes free from any equity, set-off or
cross-claim against the original or an intermediate holder of such Notes. 


  

	9.	 NOTES NOT TO BE QUOTED



 No application has been, or shall be, made (unless pursuant to paragraph 7.2 of Part 1 of Schedule 2) to any
investment exchange (whether in the United Kingdom or otherwise) for permission to deal in, or for an official or other listing or quotation, in respect of the Notes. 
  

	10.	 SET-OFF 



Payments of principal and interest in respect of the Notes shall be paid by the Company to the Noteholders in accordance with the Conditions
without any deduction or withholding (whether in respect of any set-off, counterclaim or otherwise whatsoever) unless the deduction or withholding is required by law. 

  
 15 














	11.	 MEETINGS OF NOTEHOLDERS 



Meetings of the Noteholders shall be convened and held in accordance with the provisions of Schedule 3. 

 

	12.	 VARIATION 



 

	12.1	 All or any of the rights for the time being attached to the Notes or other provisions of this Instrument may
from time to time (whether or not the Company is being wound up) be altered or abrogated with the prior written consent of a Noteholder Majority. Any such alteration or abrogation shall be effected by way of deed poll executed by the Company and
expressed to be supplemental to this Instrument. 


  

	12.2	 Modifications to this Instrument which are of a minor nature or made to correct a manifest error may be
effected by way of deed poll executed by the Company and expressed to be supplemental to this Instrument. 


  

	12.3	 The Company shall, within 5 Business Days of making any variation pursuant to this clause 12, send to each
Noteholder (or, in the case of joint holders, to the Noteholder named first in the Register) a copy of the deed poll (or other document) effecting the variation. 



 

	12.4	 Any modification, alteration or abrogation made pursuant to clause 12.1 or clause 12.2 shall be binding on all
the Noteholders. 


  

	13.	 ENFORCEMENT AND THIRD PARTY
RIGHTS 


  

	13.1	 From and after the date of this Instrument, and for so long as any Notes are outstanding or any amount is
payable or repayable by the Company in respect of the Notes, the Company undertakes to duly perform and observe its obligations under this Instrument. 


  

	13.2	 Except as expressly provided in clause 13.3, a person who is not a party to this Instrument shall not have any
rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Instrument. 



  
 16 














	13.3	 This Instrument shall operate for the benefit of all Noteholders and each Noteholder shall be entitled to sue
for the performance or observance of the provisions of this Instrument in his own right so far as his own holding of Notes is concerned. 


  

	14.	 NOTICES 



Any notice to be given to or by any Noteholder(s) for the purposes of this Instrument shall be given in accordance with the provisions of
paragraph 9 and paragraph 10 of Part 3 of Schedule 2. 
  

	15.	 GOVERNING LAW AND JURISDICTION



  

	15.1	 This Instrument and the Notes and any dispute or claim arising out of or in connection with any of them or
their subject matter or formation (including non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. 



 

	15.2	 The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of
or in connection with this Instrument or the Notes or their subject matter or formation (including non-contractual disputes or claims). 



This instrument has been executed as a deed and is delivered and takes effect on the date stated at the beginning of it. 

  
 17 













 Schedule 1 

Part 1. - Form of Tranche 1 Note Certificate 

Certificate No. [NUMBER] 
 Date of Issue [•]
[June] 2020 
 Amount £[AMOUNT] 

MEREO BIOPHARMA GROUP PLC 

£[AMOUNT] 
 UNSECURED
CONVERTIBLE LOAN NOTES 
 Created and issued pursuant to a resolution of a duly appointed committee of the board of directors of the Company passed on
3 June 2020. 
 THIS IS TO CERTIFY THAT [NAME OF NOTEHOLDER] is the registered holder of £[AMOUNT] of the £[AMOUNT]
unsecured convertible loan notes 2023 constituted by an instrument entered into by the Company on [•] [June] 2020 (“Instrument”). These are Tranche 1 Notes. Such Tranche 1 Notes are issued with the benefit of and subject to the
provisions contained in the Instrument and the Conditions endorsed on or annexed to this Certificate. 
 Notes: 

1. The Tranche 1 Notes are repayable and shall bear interest in accordance with the Conditions. 

2. This Certificate must be surrendered to the Company before any transfer or repayment, whether of the whole or any part of the Tranche 1 Notes comprised in
it, can be registered or effected, or any new certificate issued in exchange. 
 3. Any change of address of the Noteholder(s) must be notified in writing
signed by the Noteholder(s) to the Company at the Registered Office. 
 4. Subject to the Conditions, the Tranche 1 Notes are transferable in amounts and in
integral multiples of £1. 
 5. No transfer of any part of the Tranche 1 Notes represented by this Certificate can be registered without production of
this Certificate. 
 6. Words and expressions defined in the Instrument shall bear the same meaning in this Certificate and in the Conditions. 

7. The Tranche 1 Notes and any dispute or claim arising out of or in connection with any of them or their subject matter or formation (including
non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
connection with the Tranche 1 Notes or their subject matter or formation (including non-contractual disputes or claims). 
  

  
 18 













 8. A copy of the Instrument is available for inspection at the registered office of the Company. 

This Certificate has been executed as a deed and is delivered and takes effect on the date of issue stated at the beginning of it. 

Executed as a deed by MEREO BIOPHARMA GROUP PLC acting by [NAME OF DIRECTOR], a director 

 

			
	  

	[SIGNATURE OF DIRECTOR]
	
	Director in the presence of:


			
		
	Witness Signature:	 	
             




			
		
	Name:	 	
             




			
		
	Address:	 	
             




			
	
	Occupation
	
	Dated: [INSERT DATE]


  
 19 













 Part 2. - Form of Tranche 2 Note Certificate 

Certificate No. [NUMBER] 
 Date of Issue [•]
[•] [•] 
 Amount £[AMOUNT] 

MEREO BIOPHARMA GROUP PLC 

£[AMOUNT] 
 UNSECURED
CONVERTIBLE LOAN NOTES 
 Created and issued pursuant to a resolution of a duly appointed committee of the board of directors of the Company passed on
3 June 2020. 
 THIS IS TO CERTIFY THAT [NAME OF NOTEHOLDER] is the registered holder of £[AMOUNT] of the £[AMOUNT] unsecured convertible
loan notes with a Maturity Date of [•], constituted by an instrument entered into by the Company on [•] [June] 2020 (“Instrument”). These are Tranche 2 Notes. Such Tranche 2 Notes are issued with the benefit of and subject
to the provisions contained in the Instrument and the Conditions endorsed on or annexed to this Certificate. 
 Notes: 

1. The Tranche 2 Notes are repayable and shall bear interest in accordance with the Conditions. 

2. This Certificate must be surrendered to the Company before any transfer or repayment, whether of the whole or any part of the Tranche 2 Notes comprised in
it, can be registered or effected, or any new certificate issued in exchange. 
 3. Any change of address of the Noteholder(s) must be notified in writing
signed by the Noteholder(s) to the Company at the Registered Office. 
 4. Subject to the Conditions, the Tranche 2 Notes are transferable in amounts and in
integral multiples of £1. 
 5. No transfer of any part of the Tranche 2 Notes represented by this Certificate can be registered without production of
this Certificate. 
 6. Words and expressions defined in the Instrument shall bear the same meaning in this Certificate and in the Conditions. 

7. The Tranche 2 Notes and any dispute or claim arising out of or in connection with any of them or their subject matter or formation (including
non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
connection with the Tranche 2 Notes or their subject matter or formation (including non-contractual disputes or claims). 

  
 20 













 8. A copy of the Instrument is available for inspection at the registered office of the Company. 

This Certificate has been executed as a deed and is delivered and takes effect on the date of issue stated at the beginning of it. 

Executed as a deed by MEREO BIOPHARMA GROUP PLC acting by [NAME OF DIRECTOR], a director 

 

			
	
	  

	[SIGNATURE OF DIRECTOR]
	
	Director in the presence of:


			
		
	Witness Signature:	 	
             




			
		
	Name:	 	
             




			
		
	Address:	 	
             




			
	
	Occupation
	
	Dated: [INSERT DATE]


  
 21 













 Part 3. - Form of Tranche 3 Note Certificate 

Certificate No. [NUMBER] 
 Date of Issue [•]
[•] [•] 
 Amount £[AMOUNT] 

MEREO BIOPHARMA GROUP PLC 

£[AMOUNT] 
 UNSECURED
LOAN NOTES 
 Created and issued pursuant to a resolution of a duly appointed committee of the board of directors of the Company passed on 3 June 2020.

 THIS IS TO CERTIFY THAT [NAME OF NOTEHOLDER] is the registered holder of £[AMOUNT] of the £[AMOUNT] unsecured loan notes with a Maturity Date
of [•] June 2025, constituted by an instrument entered into by the Company on [•] [June] 2020 (“Instrument”). These are Tranche 3 Notes. Such Tranche 3 Notes are issued with the benefit of and subject to the provisions
contained in the Instrument and the Conditions endorsed on or annexed to this Certificate. 
 Notes: 

1. The Tranche 3 Notes are repayable and shall bear interest in accordance with the Conditions. 

2. This Certificate must be surrendered to the Company before any transfer or repayment, whether of the whole or any part of the Tranche 3 Notes comprised in
it, can be registered or effected, or any new certificate issued in exchange. 
 3. Any change of address of the Noteholder(s) must be notified in writing
signed by the Noteholder(s) to the Company at the Registered Office. 
 4. Subject to the Conditions, the Tranche 3 Notes are transferable in amounts and in
integral multiples of £1. 
 5. No transfer of any part of the Tranche 3 Notes represented by this Certificate can be registered without production of
this Certificate. 
 6. Words and expressions defined in the Instrument shall bear the same meaning in this Certificate and in the Conditions. 

7. The Tranche 3 Notes and any dispute or claim arising out of or in connection with any of them or their subject matter or formation (including
non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
connection with the Tranche 3 Notes or their subject matter or formation (including non-contractual disputes or claims). 
 8. A copy of the Instrument is
available for inspection at the registered office of the Company. 
 This Certificate has been executed as a deed and is delivered and takes effect on the
date of issue stated at the beginning of it. 

  
 22 













 Executed as a deed by MEREO BIOPHARMA GROUP PLC acting by [NAME OF DIRECTOR], a director 

 

			
	  

	[SIGNATURE OF DIRECTOR]
	
	Director in the presence of:


			
		
	Witness Signature:	 	
             




			
		
	Name:	 	
             




			
		
	Address:	 	
             




			
	
	Occupation
	
	Dated: [INSERT DATE]


  
 23 













 Schedule 2 The Conditions 

Part 1. Interest, repayment and redemption 
  

	1.	 INTEREST 


  

	1.1	 Interest shall initially be payable on any outstanding Tranche 1 Notes (so far as not converted under Part 2 of
Schedule 2) at a fixed rate of 10% per annum (the “Interest Rate”), subject to the following adjustments: 


  

	 	(a)	 if Shareholder Approval is obtained on or prior to 7 August 2020, the initial 10% rate shall be reduced to
6% per annum, with effect retroactively as of the Effective Date; 


  

	 	(b)	 if an Event of Default takes place and is not remedied by the Company in accordance with the applicable
provisions of this Part 1 of Schedule 2, the Tranche 1 Interest Rate shall be increased by 2% per annum with effect from the date of such Event of Default (or, if applicable, the expiry of any cure period applicable thereto) (the
“Tranche 1 Default Rate”); and 


  

	 	(c)	 if the Tranche 1 Extension Option is exercised, interest shall cease to be payable on the Tranche 1 Notes from
the date of the relevant Tranche 1 Extension Notice (other than any interest payable at the Tranche 1 Default Rate following an Event of Default, which, for the avoidance of doubt, shall apply at a flat rate of 2% in such circumstances and remain
payable). 


  

	1.2	 Interest shall not be payable on any outstanding Tranche 2 Notes or Tranche 3 Notes other than where an Event
of Default takes place and is not remedied by the Company in accordance with the applicable provisions of this Part 1 of Schedule 2, where interest shall be payable on the Tranche 2 Notes and/or Tranche 3 Notes (as applicable) at a rate of
2% per annum with effect from the date of such Event of Default (or, if applicable, the expiry of any cure period applicable thereto) (the “Tranche 2 Default Rate” and “Tranche 3 Default Rate”, respectively).



  

	1.3	 Any interest due under paragraphs 1.1 or 1.2 shall be payable on the Redemption Date. 



  
 24 














	1.4	 Interest, if payable, shall accrue daily at the Interest Rate and shall be calculated on the basis of a 365-day
year and the actual number of days elapsed from the date of issue of the relevant Notes to the Redemption Date. 


  

	1.5	 If the Company fails to pay redemption monies when due, interest shall accrue on the unpaid amount at the
applicable Default Rate. 


  

	2.	 REPAYMENT OF PRINCIPAL 



 

	2.1	 As and when the Notes (or any part of them) are to be redeemed in accordance with paragraph 4 of this Part 1 of
Schedule 2, the Company shall pay the Noteholders the principal amount of the Notes which are to be redeemed, subject to adjustment in accordance with paragraph 4.2 of this Part 2 of Schedule 2. 



 

	2.2	 No prepayment of the principal amount of the Notes or any interest accrued thereon prior to the earlier of the
Maturity Date or, in the event of a Change of Control, the date on which the consideration in respect of such Change of Control is remitted to the holders of Ordinary Shares, shall be permitted without the consent of a Noteholder Majority, and, if
required, the consent of the Senior Lenders pursuant to the terms of the Subordination Deed. 


  

	2.3	 At any time prior to the Tranche 1 Maturity Date, a Qualifying Noteholder may (but shall not be required to)
notify the Company that it wishes to extend the Tranche 1 Maturity Date in respect of that Noteholder’s Tranche 1 Notes to a new date to be specified in such notice provided such date is a Business Day and not later than the date 10 years after
the date of this Instrument (a “Tranche 1 Extension Notice”), and the Company shall accept such extension (the “Tranche 1 Extension Option”), whereupon the Tranche 1 Maturity Date shall be revised accordingly. A
Qualifying Noteholder may only issue a Tranche 1 Extension Notice once and any such Tranche 1 Extension Option must be used in respect of all Tranche 1 Notes held by such Qualifying Noteholder. From the date of such Tranche 1 Extension Notice, other
than amounts accrued prior to delivery of the Tranche 1 Extension Notice, no additional interest shall be payable on the Tranche 1 Notes held by the exercising Qualifying Noteholder (other than any interest which becomes payable at the Tranche 1
Default Rate). 



  
 25 














	2.4	 On the date of the Tranche 1 Extension Notice the exercising Qualifying Noteholder shall deliver to the Company
the Tranche 1 Note Certificate in respect of the Tranche 1 Notes which are the subject of such Tranche 1 Extension Notice, and the Company shall, within 5 Business Days’ of the exercise of the Tranche 1 Extension Option, issue to such
Qualifying Noteholder a replacement Tranche 1 Note Certificate bearing the revised Tranche 1 Maturity Date. 


  

	2.5	 A Qualifying Noteholder who holds both Tranche 1 Notes and Tranche 2 Notes may (but shall not be required) if
they have already served an Extension Notice (or contemporaneously with the service of an Extension Notice), notify the Company that it wishes to extend the Tranche 2 Maturity Date in respect of that Noteholder’s Tranche 2 Notes to the same
date that it has specified as the Tranche 1 Maturity Date pursuant to its Extension Notice for Tranche 1 Notes (such further notice being a “Tranche 2 Extension Notice”), and the Company shall accept such extension (the
“Tranche 2 Extension Option”), whereupon the Tranche 2 Maturity Date shall be revised accordingly. A Qualifying Noteholder may only issue a Tranche 2 Extension Notice once and any such Tranche 2 Extension Option must be used in
respect of all Tranche 2 Notes held by such Qualifying Noteholder. 


  

	2.6	 On the date of the Tranche 2 Extension Notice the exercising Qualifying Noteholder shall deliver to the Company
the Tranche 2 Note Certificate in respect of the Tranche 2 Notes which are the subject of such Tranche 2 Extension Notice, and the Company shall, within 5 Business Days’ of the exercise of the Tranche 2 Extension Option, issue to such
Qualifying Noteholder a replacement Tranche 2 Note Certificate bearing the revised Tranche 2 Maturity Date. 


  

	2.7	 Any Qualifying Noteholder who holds Tranche 3 Notes may (but shall not be required), notify the Company that it
wishes to extend the Tranche 3 Maturity Date in respect of that Qualifying Noteholder’s Tranche 3 Notes to a new date to be specified in such notice provided such date is a Business Day and not later than the date 10 years after the date of
this Instrument (such notice being a “Tranche 3 Extension Notice”). Upon receipt of a Tranche 3 Extension Notice, the Company may reject a Tranche 3 Extension Notice by providing written notice of such rejection to the Noteholder
within 30 Business Days of receipt of such Tranche 3 Extension Notice (whereupon no extension of such Noteholder’s Tranche 3 Notes shall occur). If the Company does not reject a Tranche 3 Extension Notice within such foregoing period, the
Tranche 3 Extension Notice shall be considered accepted (the “Tranche 3 Extension Option”), whereupon the Tranche 3 Maturity Date shall be revised accordingly. A Qualifying Noteholder may only issue a Tranche 3 Extension Notice once
and any such Tranche 3 Extension Option must be used in respect of all Tranche 3 Notes held by such Qualifying Noteholder. 



  
 26 














	2.8	 On the date of the Tranche 3 Extension Notice the exercising Qualifying Noteholder shall deliver to the Company
the Tranche 3 Note Certificate in respect of the Tranche 3 Notes which are the subject of such Tranche 3 Extension Notice. If the Company rejects the Tranche 3 Extension Notice, the Company shall promptly return such Tranche 3 Note Certificate to
the Noteholder. If the Tranche 3 Extension Option is accepted, the Company shall, within 5 Business Days’ of the exercise of the Tranche 3 Extension Option, issue to such Qualifying Noteholder a replacement Tranche 3 Note Certificate bearing
the revised Tranche 3 Maturity Date. 


  

	3.	 TIME OF PAYMENT 



Whenever any payment of principal (or otherwise) becomes due on a day which is not a Business Day, payment shall be made on the next following
Business Day. 
  

	4.	 REDEMPTION 



 

	4.1	 The Notes then in issue (so far as not converted under Part 2 of this Schedule 2) shall be redeemed at the
principal amount together with interest on the Notes outstanding at the applicable Interest Rate on the earlier of the following dates: 


  

	 	(a)	 the Tranche 1 Maturity Date, Tranche 2 Maturity date or Tranche 3 Maturity date (as applicable); or



  

	 	(b)	 in the event of a Change of Control, the date on which the consideration in respect of such Change of Control
is remitted to the holders of Ordinary Shares; or 


  

	 	(c)	 following the occurrence of an Event of Default and the expiry of any applicable grace period applicable to
such Event of Default as set out in paragraph 5 of this Part 1 of Schedule 2 (the date on which an Event of Default occurs or, if later, the relevant grace period (if any) expires, the “Acceleration Date”), the date specified in the
relevant Redemption Notice; 


 (the “Redemption Date”). 

 

	4.2	 Subject to paragraph 4.12 below, in the event that Shareholder Approval has not been obtained on or before
7 August 2020, in addition to the amounts otherwise payable on the Redemption Date, each Noteholder holding any Tranche 1 Notes shall be entitled to be paid an additional sum on the Redemption Date, the amount of which shall be equal to the
principal amount of the Tranche 1 Notes outstanding on 7 



  
 27 














	 	August, 2020 and held by such Noteholder in recognition of such Noteholder not being able to (i) participate in the equity of the Company through conversion of the Tranche 1 Notes, or (ii) benefit from any
Warrants that were intended to be issued to such Tranche 1 Noteholder as part of the Transaction (such sum being the “Uplift Payment”). Notwithstanding the foregoing, in the event that Shareholder Approval has not been
obtained on or before 7 August 2020, upon conversion of the Notes in accordance with Part 2 of Schedule 2, the Noteholder shall be entitled to the benefit of the Uplift Payment. In the event that the Shareholder Approval has not been obtained
on or before 7 August 2020 and a Noteholder did not attend (either in person or by proxy) any general meeting of the Company’s members called for the purposes of obtaining the Shareholder Approval and vote in favour of such Shareholder
Approval with the entirety of all voting rights available to such Noteholder, such Noteholder shall cease to be entitled to the benefit of the Uplift Payment in any circumstances. 


 

	4.3	 At any time after 7 August 2020, when (i) at least one Tranche 1 Noteholder is entitled to the Uplift
Payment pursuant to paragraph 4.2 above; (ii) the Closing Price is above the Tranche 1 Conversion Price; and (iii) the Company has authority from its shareholders to allot additional Ordinary Shares, the Company may at its discretion
notify all (but not some) Tranche 1 Noteholders that it wishes to satisfy its obligations in respect of all or any portion of the Uplift Payment by the issuance of further Ordinary Shares pro rata to all Noteholder(s) (such Ordinary Shares being
“Uplift Securities”) (such notice an “Uplift Allocation Notice”). 


  

	4.4	 The amount of the Uplift Payment to be satisfied by the Uplift Securities shall be calculated by: multiplying
(x) being the number of Uplift Securities the Company wishes to issue, by (y) being the Tranche 1 Conversion Price (the “Uplift Reduction Amount”). 



 

	4.5	 The Uplift Allocation Notice served pursuant to paragraph 4.3 above shall specify, at a minimum:



  

	 	(a)	 the number of Uplift Securities the Company proposes to issue; 



 

	 	(b)	 each Tranche 1 Noteholder’s current percentage holding of the aggregate voting rights in the Company; and



  

	 	(c)	 the issue date of the Uplift Securities (which shall in all cases be within 5 Business Days of the date the
Uplift Allocation Notice was served). 



  
 28 














	4.6	 In the event that: 


  

	 	(a)	 there is only one Tranche 1 Noteholder, that Noteholder shall be automatically deemed to have subscribed for
the maximum number of Uplift Securities as it is possible to subscribe without the Ownership Limit of that Tranche 1 Noteholder being exceeded; and 


  

	 	(b)	 if there is more than one Tranche 1 Noteholder, each Tranche 1 Noteholder shall be automatically deemed to have
subscribed (and such subscription shall be deemed satisfied out of each Tranche 1 Noteholder’s entitlement to the Uplift Payment) for such number of Uplift Securities as is determined pro rata to each Tranche 1 Noteholder’s proportionate
entitlement to the Uplift Payment (provided that such amount does not result in the Ownership Limit being exceeded, and if it was to so result, such Tranche 1 Noteholder shall be required to subscribe for the maximum amount of Uplift Securities that
such Tranche 1 Noteholder could receive without being in breach of the Ownership Limit, any excess Uplift Securities would then be allocated to each other Tranche 1 Noteholder (who would be deemed to subscribe for the same) pro rata to their
entitlement to the Uplift Payment until either all Uplift Securities have been allocated amongst all Tranche 1 Noteholders or all Tranche 1 Noteholders have each reached the Ownership Limit), 



and in each case the Company shall issue such Uplift Securities (which shall be credited as fully paid and rank pari passu with Ordinary Shares
of the same class in issue on the Conversion Date) within 5 Business Days of the Uplift Allocation Notice and the applicable Tranche 1 Noteholder’s entitlement to the Uplift Payment shall thereon be reduced by their proportion of the Uplift
Reduction Amount. 
  

	4.7	 At any time when (i) the Company has satisfied the entirety of its obligations in respect of the Uplift
Payment through the issue of Uplift Securities pursuant to paragraphs 4.3 to 4.6 above (or the Uplift Payment has otherwise been discharged or waived); (ii) the Closing Price is above the Tranche 1 Conversion Price, and (iii) the Company
has authority from its shareholders to allot additional Ordinary Shares; the Company may notify all (but not some) of the Tranche 1 Noteholders that it wishes to satisfy its obligations in respect of an amount of interest and/or principal under the
Tranche 1 Notes by the issuance of further Ordinary Shares pro rata to all Tranche 1 Noteholders (such Ordinary Shares being “Pay Down Securities”) (such notice a “Pay Down Notice” and such process a “Pay
Down Issue”). 



  
 29 














	4.8	 The amount of principal and interest in respect of the Tranche 1 Notes to be satisfied by the issue of Pay Down
Securities shall be calculated by: multiplying (x) being the number of Pay Down Securities the Company wishes to issue, by (y) being the Tranche 1 Conversion Price (the “Pay Down Reduction Amount”). 



 

	4.9	 The Pay Down Notice served on each Tranche 1 Noteholder pursuant to paragraph 4.7 above shall specify, at a
minimum: 


  

	 	(a)	 the number of Pay Down Securities the Company proposes to issue; 



 

	 	(b)	 each Tranche 1 Noteholder’s current percentage holding of the aggregate voting rights in the Company; and



  

	 	(c)	 the issue date of the Pay Down Securities (which shall in all cases be within 5 Business Days of the date the
Pay Down Notice was served). 


  

	4.10	 In the event that: 


  

	 	(a)	 there is only one Tranche 1 Noteholder, that Tranche 1 Noteholder shall be automatically deemed to have
subscribed for the maximum number of Pay Down Securities as it is possible to subscribe without the Ownership Limit of that Tranche 1 Noteholder being exceeded; and 



 

	 	(b)	 there is more than one Tranche 1 Noteholder, each Tranche 1 Noteholder shall be automatically deemed to have
subscribed (and such subscription shall be deemed satisfied out of each Tranche 1 Noteholder’s entitlement to principal and/or interest under the Notes) for the maximum amount of Pay Down Securities that such Tranche 1 Noteholder could receive
without being in breach of the Ownership Limit, any excess Pay Down Securities would then be allocated to each other Tranche 1 Noteholder (who would be deemed to subscribe for the same) pro rata to their entitlement outstanding interest and/or
principal under the Tranche 1 Notes until either all Pay Down Securities have been allocated amongst all Tranche 1 Noteholders or all Tranche 1 Noteholders have each reached the Ownership Limit, 



and in each case the Company shall issue such Pay Down Securities (which shall be credited as fully paid and rank pari passu with Ordinary
Shares of the same class in issue on the Conversion Date) within 5 Business Days of the Pay Down Notice and the applicable Tranche 1 Noteholder’s entitlement to principal amount and/or interest shall thereon be reduced by their proportion of
the Pay Down Reduction Amount. 

  
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	4.11	 At any time when (i) the Company has satisfied all principal and interest outstanding in respect of the
Tranche 1 Notes by the issue of Pay Down Securities; (ii) the Closing Price is above the Tranche 2 Conversion Price, and (iii) the Company has authority from its shareholders to allot additional Ordinary Shares, the Company may serve a Pay
Down Notice on the Tranche 2 Noteholders, notifying them it wishes to satisfy its obligations in respect of any interest and/or principal amount under the Tranche 2 Notes by way of a Pay Down Issue, and the provisions of the foregoing paragraphs 4.7
to 4.10 above shall apply mutatis mutandis in respect of any such Pay Down Issue in respect of the Tranche 2 Notes (and in such circumstances, for the avoidance of doubt, (y) for the purposes of calculating the Pay Down Reduction Amount
pursuant to paragraph 4.8 shall be the Tranche 2 Conversion price). At any time when (i) the Company has satisfied all principal and interest outstanding in respect of the Tranche 2 Notes by the issue of Pay Down Securities; and (ii) the
Company has authority from its shareholders to allot additional Ordinary Shares, the Company may serve a Pay Down Notice on the Tranche 3 Noteholders, notifying them it wishes to satisfy its obligations in respect of any interest and/or principal
amount under the Tranche 3 Notes by way of a Pay Down Issue, and the provisions of the foregoing paragraphs 4.7 to 4.10 above shall apply mutatis mutandis in respect of any such Pay Down Issue in respect of the Tranche 3 Notes (and in such
circumstances, for the avoidance of doubt, (y) for the purposes of calculating the Pay Down Reduction Amount in respect of Tranche 3 Notes pursuant to paragraph 4.8 shall be the weighted average of the Closing Price on the 5 Business Days
immediately prior to the date on which the Pay Down Notice is served in respect of such Tranche 3 Notes). 


  

	4.12	 In the event that (i) a Change of Control occurs on or prior to 7 August 2020 and Shareholder
Approval has not been obtained on or prior to the date of such Change of Control; or (ii) Shareholder Approval has not been obtained on or before 7 August 2020 and following 7 August 2020 but prior to the Tranche 1 Maturity Date, the
Company undergoes a Change of Control; in either case the Company shall pay or cause to be paid, within 3 Business Days of the date on which consideration in respect of such Change of Control is remitted to the holders of Ordinary Shares, to each
Noteholder, in addition to the sum payable pursuant to paragraph 4.1(b) of this Part 1 of Schedule 2, an additional sum, the amount of which shall be equal to the value of (a) minus ((b), (c) and (d)), where: 



 

	 	(a)	 is the pro rata amount of consideration which would have been received by such Noteholder in consideration for
their Ordinary Shares and Warrants (plus, to the extent they exist, any Tranche 3 Notes held by such Noteholder but without double-counting in respect of the value of any Warrants that were converted into such Tranche 3 Notes by the Noteholder) on
the Change of Control if that Shareholder Approval had been obtained on or prior to 7 August 2020 and as a result (i) all the Warrants held by such Noteholder as of the date of the Change of Control had become fully exercisable on or prior
to 7 August 2020; and (ii) all Tranche 1 Notes held by such Noteholder as of the date of the Change of Control had automatically converted into Ordinary Shares upon receipt of the Shareholder Approval; and 



  
 31 














	 	(b)	 is the aggregate of the principal amount of such Noteholder’s Tranche 1 Notes, together with any accrued
but unpaid interest thereon held by such Noteholder immediately prior to the Notes being redeemed pursuant to paragraph 4.1(b) of this Part 1 of Schedule 2; and 



 

	 	(c)	 is the pro rata amount of consideration actually received or due to be received by such Noteholder pursuant to
Section 2.10 of the Warrant Instrument in respect of Warrants held by such Noteholder as of the date of such Change of Control; and 


  

	 	(d)	 is the pro rata amount of consideration actually received or due to be received by such Noteholder (whether on
or prior to any Change of Control) in respect of any Ordinary Shares received by such Noteholder in exchange for Tranche 1 Notes pursuant to paragraphs 4.7 through 4.11 of this Schedule 2; 



(such sum being the “Change of Control Payment”). For the avoidance of doubt, if any Noteholder becomes entitled to be paid
the Change of Control Payment, such Noteholder shall cease to be entitled to the Uplift Payment pursuant to paragraph 4.2. 
  

	4.13	 Subject to paragraph 6 if the Noteholder Majority wishes to redeem the Notes following an Acceleration Date,
the Noteholder Majority shall give the Company written notice of the intention to exercise the right to redeem in accordance with the provisions of paragraph 4.1(b), together with confirmation on the date for such redemption (provided that such date
may not occur earlier than the date falling 20 Business Days after the relevant Acceleration Date), conditional always on any such Event of Default not being remedied in the case of paragraph 4.1(c) (“Redemption Notice”).



  

	4.14	 A Redemption Notice shall (unless the Company agrees otherwise) be irrevocable. 



 

	4.15	 For as long as the Subordination Agreement is in force, notwithstanding any of the provisions of paragraph 5 of
this Part 1 of Schedule 2, the Notes cannot be redeemed or repaid following an Acceleration Date until the applicable restriction in the Subordination Agreement has expired or been waived by the Senior Lenders; provided that such delay in payment
shall constitute an additional Event of Default hereunder. 



  
 32 














	4.16	 On the Redemption Date, the Company shall repay to all Noteholders the principal amount of the Notes so
redeemed, together with interest on such Notes outstanding at the applicable Interest Rate, and, if applicable, the Uplift Payment payable pursuant to paragraph 4.2. 



 

	4.17	 If, on redemption of a Note, a Noteholder fails to deliver the Certificate for it, or an indemnity in
accordance with these Conditions or to accept payment of moneys due to him, the Company shall pay the moneys due to him into bank account which payment shall discharge the Company from all further obligations in respect of the Note.



  

	4.18	 The Company shall cancel any Notes repaid, redeemed or purchased and shall not reissue them.



  

	5.	 EVENTS OF DEFAULT 



Subject to paragraphs 4.15 and 6.3 of this part 1 of Schedule 2, the Notes then in issue shall become immediately redeemable at the principal
amount, together with interest on the Notes outstanding, and interest shall become payable at the applicable Default Rate, if: 
  

	 	(a)	 the Company fails to pay any interest or principal in respect of the Notes on the relevant due date;



  

	 	(b)	 the Company fails to comply in any material respect with the covenants of the Notes or any of the Conditions
and does not remedy such failure within 30 calendar days; 


  

	 	(c)	 any judgment, arbitration award, order or decree for the payment of money and that is no longer subject to an
appeal process in an amount, individually or in the aggregate of at least £1,000,000 (or its equivalent in other currencies) is rendered against any Group Company and not cured or withdrawn within 30 calendar days of such judgment, award,
order or decree; 


  

	 	(d)	 a Group Company incurs an Event of Default (as such term is defined in the Novartis Loan Note) pursuant to the
terms of the Novartis Loan Note and such Event of Default is not remedied within the greater of (i) any applicable grace period pursuant to the terms of the Novartis Loan Note; and (ii) 30 days from the occurrence of such Event of Default;
and results in the acceleration by Novartis of any indebtedness owed pursuant to the terms of the Novartis Loan Note; 



  
 33 














	(e)	 a Group Company incurs an event of default (howsoever defined) in respect of any indebtedness in a principal
amount in excess of £1,000,000 and fails to cure (or have waived) such event of default within 30 calendar days of such event of default; 


  

	(f)	 a Group Company commits a material breach of any material contract to which such Group Company is a party and
fails to cure (or have waived) such material breach within 30 calendar days of such event of default 


  

	(g)	 an encumbrancor takes possession or a receiver is appointed of the whole or the major part of the assets or
undertaking of a Group Company or if distress, execution or other legal process is levied or enforced or sued out on or against the whole or the major part of the assets of any Group Company and is not discharged, paid out, withdrawn or removed
within 30 calendar days; 


  

	(h)	 a Group Company is the subject of any proceeding in bankruptcy or for their dissolution, liquidation,
winding-up, composition or other relief under any applicable insolvency or bankruptcy laws, whether voluntary or involuntary and, if involuntary, is not dismissed within 60 calendar days of filing; 



 

	(i)	 an administration order is made in relation to any Group Company; or 



 

	(j)	 an order is made, or an effective resolution is passed, for the winding-up, liquidation, administration or
dissolution of any Group Company (except for the purpose of reorganisation or amalgamation of the Group Companies). 


  

	6.	 ACTION FOLLOWING EVENT OF DEFAULT



  

	6.1	 The Company shall give written notice to the Noteholders as soon as reasonably practicable following the
Company becoming aware of the occurrence of an event specified in paragraph 5, giving reasonable details of that event. 


  

	6.2	 Following receipt of the notice provided pursuant to paragraph 6.1 above, and, if applicable, the expiry of any
cure period provided for such Event of Default, the Noteholders shall have a period of 10 Business Days in which they may exercise their right to waive such Event of Default by Noteholder Majority Consent. 



 

	6.3	 If the Noteholder Majority waives any Event of Default then the Notes shall cease to be immediately redeemable,
and no further interest shall accrue at the applicable Default Rate in respect of such Event of Default (for the avoidance of doubt, notwithstanding such waiver, the Noteholders’ shall remain entitled to any interest accrued at the applicable
Default Rate between the date of the Event of Default and the date of waiver by the Noteholder Majority). 



  
 34 














	7.	 TAXATION 



 

	7.1	 All payments to be made by the Company to a Noteholder under the Note shall be made free and clear of and
without any deduction or withholding for or on account of tax (a “Tax Deduction”), unless a Tax Deduction is required by law. If a Tax Deduction is required by law, the amount of the payment due from the Company shall be increased
to an amount which (after making any Tax Deduction) leaves an amount equal to the payment which would have been due if no Tax Deduction had been required. 


  

	7.2	 Each Noteholder shall, in consultation with the Company, take all reasonable steps to mitigate any
circumstances which arise and which would result in any amount becoming payable under or pursuant to paragraph 7.1 above, including (but not limited to) transferring its rights and obligations under this Instrument and the Notes to another affiliate
of such Noteholder and permitting the listing of the Notes on a recognised stock exchange. 


  

	7.3	 Paragraph 7.2 above does not in any way limit the obligations of the Company under this Instrument.



  

	7.4	 Each Noteholder and the Company shall co-operate in completing any procedural formalities necessary for the
Company to obtain authorisation to make that payment without a Tax Deduction including using commercially reasonable endeavours to procure that investors in such Noteholder complete such procedural formalities. 



 

	7.5	 If the Company makes an increased payment under paragraph 7.1 (a “Tax Payment”) and the
relevant Noteholder shall (and shall use commercially reasonable endeavours to procure that investors will) co-operate with the Company to take any reasonable steps to: 



 

	 	(a)	 investigate the availability of any credit against, relief or remission for, or repayment of any Tax is
attributable to that increased payment of which that Tax Payment forms part, to that Tax Payment or to a Tax Deduction in consequence of which that Tax Payment was required (“Tax Credit”); and 



 

	 	(b)	 obtain and/or utilise that Tax Credit, 



  
 35 













 and the Noteholder shall (and shall use commercially reasonable endeavours to procure that
investors will) pay an amount to the Company which that Noteholder (or investors as applicable) determines (acting reasonably) will leave it (after that payment) in the same after-Tax position as it would have been in had some or all of the Tax
Payment not been required to be made by the Company. 
 Part 2. Conversion 

 

	1.	 CONVERSION 



 

	1.1	 Without prejudice to the provisions paragraphs 4.3 to 4.11 of Schedule 2 Part 1, the Notes shall not be capable
of conversion prior to Shareholder Approval having been obtained and no Noteholder shall serve any Conversion Notice prior to such time. 


  

	1.2	 Subject to paragraph 1.1 and paragraph 1.4 of this Part 2 of Schedule 2, all outstanding Tranche 1 Notes shall
automatically convert into a number of fully paid Ordinary Shares upon Shareholder Approval being obtained, determined by dividing(x) the sum of (i) the outstanding principal amount, plus (ii) all accrued and unpaid interest thereon, plus
(iii) any amount of the Uplift Payment (to the extent the same is applicable pursuant to the terms of this Instrument) which has become due and payable in accordance with paragraph 4.2 and has not already been paid or satisfied by the issue of
Uplift Securities (or otherwise), by (y) the Tranche 1 Conversion Price then in effect; provided that (but subject to paragraph 1.4 of this Part 2 of Schedule 2 below) following such conversion, no individual Noteholder shall hold more
than 9.99% of the aggregate voting rights in the Company (on a fully diluted basis) (the “Ownership Limit”). In the event that Conversion of any Noteholder’s holding of Notes would result in such Noteholder exceeding the
Ownership Limit, the principal amount of the Notes held by such Noteholder which shall convert shall be the greatest amount possible without that Noteholder exceeding such Ownership Limit and the remaining principal balance on such Notes shall
remain outstanding. 


  

	1.3	 Subject to paragraphs 1.1, 1.2 and 1.4 of this Part 2 of Schedule 2: 



 

	 	(a)	 each Noteholder holding Tranche 1 Notes shall have the right, at any time prior to the Tranche 1 Maturity Date,
to serve a Conversion Notice on the Company to convert all or, if the Ownership Limit applies, part of such Noteholder’s Tranche 1 Notes then outstanding (together with any accrued but unpaid interest thereon) into fully paid Ordinary Shares at
the Tranche 1 Conversion Price per Share; and 



  
 36 














	 	(b)	 each Noteholder holding Tranche 2 Notes shall have the right, at any time prior to the Tranche 2 Maturity Date
applicable to such Noteholder’s Tranche 2 Notes, to serve a Conversion Notice on the Company to convert all or, if the Ownership Limit applies, part of such Noteholder’s Tranche 2 Notes then outstanding (together with any accrued but
unpaid interest thereon) into fully paid Ordinary Shares at the Tranche 2 Conversion Price per Share, 


 provided that, in
each of the foregoing cases, at the time of the Conversion Notice, either (i) such Noteholder’s aggregate voting rights in the Company is not in excess of the Ownership Limit and would not become in excess of the Ownership Limit as a
result of the conversion contemplated by such Conversion Notice; or (ii) such Noteholder has waived the application of the Ownership Limit in accordance with paragraph 1.4 of this Part 2 of Schedule 2. 

 

	1.4	 Notwithstanding the foregoing, a Noteholder may increase or decrease the Ownership Limit to any other
percentage, by written notice to the Company; provided, that the Noteholder may not decrease the limitation prior to August 8, 2020; provided further that a waiver by the Noteholder of the Ownership Limit or a request to increase the Ownership
Limit requires not less than 61 days prior written notice to the Company (with such waiver of the Ownership Limit or request to increase the Ownership Limit taking effect only upon the expiration of such 61 day notice period and applying only to the
Noteholder and not to any other holder of Notes) and that such Ownership Limit shall never be increased above 19.99%. 


  

	1.5	 The Conversion Notice shall set out, at a minimum: 



 

	 	(a)	 the principal amount of the Tranche 1 Notes and/or Tranche 2 Notes to be converted; 



 

	 	(b)	 the amount (if any) of accrued but unpaid interest on such principal amount which is to be converted;



  

	 	(c)	 the Noteholder’s current percentage holding of the aggregate voting rights in the Company;



  

	 	(d)	 the Conversion Date; 



 

	 	(e)	 whether the Ordinary Shares
resulting from conversion are to be delivered as ADSs; and 


  

	 	(f)	 (e) any conditions (if any) applicable to the conversion and
agreed in writing in advance by the Company. 



  
 37 














	1.6	 If and to the extent that the Ordinary Shares
issued are to be delivered as ADSs, the Noteholder shall be required to deliver to the Company a completed Issuance
and Delivery Instruction in the form set out in Part 4 of this Schedule 2 (as such form may be amended from time to time by notice to the Noteholder) duly
completed and executed by the Noteholder no later than 3 Business Days following service of the relevant Conversion Notice on the Company.



  

	1.7	 In the event of any failure by a Noteholder to
deliver a duly completed Issuance and Delivery Instruction within such time period the Company shall disregard such Noteholder’s request for delivery of the relevant Ordinary Shares as ADSs and shall issue the number of Ordinary Shares
specified in the Conversion Notice to the Noteholder on the Conversion Date in accordance with paragraph 2 of this Part 2 of Schedule 2.



  

	1.8	 1.6 The Service of a Conversion Notice shall be irrevocable and binding on the
Noteholder. 


  

	2.	 PROCEDURES ON CONVERSION 



 

	2.1	 Subject to paragraph 1.1 of this Part 2 of Schedule 2, on the Conversion Date, the Directors shall convert the
principal amount of the Notes and accrued but unpaid interest and any amount of the Uplift Payment (to the extent the same is applicable pursuant to the terms of this Instrument) which has become due and payable in accordance with paragraph 4.2 and
has not already been paid or satisfied by the issue of Uplift Securities (or otherwise), into such number of new fully paid Ordinary Shares at the applicable Tranche 1 Conversion Price or Tranche 2 Conversion Price (as the case may be) as set out in
paragraph 1 of this Part 2 of Schedule 2 in accordance with the following provisions of paragraph 2.2 to paragraph 2.5 (inclusive). 


  

	2.2	 Conversion of the Notes shall be effected by the Company redeeming the relevant Notes on the Conversion Date.
Each Noteholder whose Notes are being converted shall be deemed to irrevocably authorise and instruct the Company to apply the redemption moneys payable to that Noteholder in subscribing for Ordinary Shares on conversion of the Notes.




  
 38 














	2.3	 In the event that a Noteholder has stated in the
relevant Conversion Notice that the Ordinary Shares arising from conversion are to be delivered as ADSs, and there is an effective registration statement covering the Ordinary Shares to be issued on such conversion, then such Ordinary Shares may be
issued to, and deposited with (and otherwise registered in the name of) the custodian (or its nominee) of the Depositary, and following such issuance and deposit the Company will direct the Depositary to issue an amount of ADSs via DTC (with such
ADSs being eligible for listing on Nasdaq) in accordance with the corresponding Issuance and Delivery Instruction. 


  

	2.4	 2.3 Ordinary Shares arising on conversion of the Notes (and any applicable
accrued but unpaid interest) shall be issued and allotted by the Company to the Noteholder or (where a Noteholder has delivered an Issuance and Delivery Instruction) to
the custodian of the Depositary on the Conversion Date and the certificates (if physical certificates are requested by such Noteholder) for such Ordinary Shares shall be despatched to the persons entitled to them at their own risk.



  

	2.5	 2.4 The Ordinary Shares arising on conversion of the Notes shall
be credited as fully paid and rank pari passu with Ordinary Shares of the same class in issue on the Conversion Date and shall carry the right to receive all dividends and other distributions declared, made or paid after the Conversion Date.



  

	2.6	 2.5 The entitlement of each Noteholder to a fraction of a Share
shall be rounded down to the nearest whole number of Ordinary Shares which result from the conversion of the Notes. 


  

	2.7	 In the event that a Noteholder
requires Ordinary Shares arising on conversion to be delivered as ADSs, the entitlement of such Noteholder to ADSs shall be calculated using the ADS Exchange Ratio. No fractional ADSs will be issued, and any fractional entitlements to an ADS shall
be issued to the relevant Noteholder in the form of Ordinary Shares in accordance with Part 2 of this Schedule 2, rounded down to the nearest whole share. 



 

	2.8	 2.6 In the event that the Ordinary Shares in issue on the Conversion Date are
traded on the AIM Market operated by London Stock Exchange plc, the Company shall use its reasonable best endeavours to ensure that the Ordinary Shares to be issued upon the conversion of the relevant Notes are admitted to trading on the AIM Market
as soon as reasonably practicable following the Conversion Date. In addition, as soon as practicable following the general meeting at which the Company seeks to obtain Shareholder Approval, the Company shall make or cause to be made an application
to AIM for a block listing (up to the maximum amount available to the Company under AIM block listing rules and in consideration of block listings registered at the 



  
 39 














	 	time of this Agreement) or otherwise to admit upon Admission or as soon as permitted by AIM thereafter the maximum number of Ordinary Shares that may be acquired upon conversion of the Notes. Further, the Company shall
list the Ordinary Shares issuable upon conversion of the Notes on each other securities exchange on which the Ordinary Shares are then listed and/or admitted to trading. 


Part 3. Transfer provisions, Undertakings and other matters 
  

	1.	 The Company shall recognise the registered holder of any Notes as the absolute owner of them and shall not
(except as provided by statute or as ordered by a court of competent jurisdiction) be bound to take notice or see to the execution of any trust (whether express, implied or constructive) to which any Note may be subject. The Company shall not
(except as provided by statute or as ordered by a court of competent jurisdiction) be bound to enter any notice of any trust (whether express, implied or constructive) on the register in respect of any of the Notes. 



The Notes are freely transferable in accordance with this Part 3 of Schedule 2 in integral multiples of £1 by instrument in writing in
the usual common form (or in such other form as the Directors may approve) and such instrument need not be under seal. Additionally and, notwithstanding any other provision of this Instrument, for so long as the Subordination Agreement remains in
force and effect, no transfer of the Notes may take place unless the transferee in respect of those Notes being transferred is either a party to the Subordination Agreement or has entered into a deed of adherence to be bound by the terms of such
Subordination Agreement, or has otherwise entered into subordination arrangements with the Senior Lenders in writing or the requirement to enter into subordination arrangements with the Senior Lenders has been otherwise waived by the Senior Lenders
in writing in advance of such intended transfer of the Notes; any attempt to transfer Notes in breach of the foregoing provisions is void ab initio. 
  

	2.	 Each instrument of transfer shall be signed by the transferor, and the transferor shall be deemed to remain the
owner of the Notes to be transferred until the name of the transferee is entered in the register in respect of such Notes. 


  

	3.	 Each instrument of transfer shall be sent to, or left for registration at, the registered office of the Company
for the time being, and shall be accompanied by the Certificate(s) for the Notes to be transferred and any other evidence that the Company may require to prove the title of the transferor or his right to transfer the Notes (and, if such instrument
is executed by some other person on his behalf, the authority of that person to do so). All instruments of transfer that are registered may be retained by the Company. 



  
 40 














	4.	 No transfer of Notes shall be registered in respect of which a Redemption Notice, an Uplift Allocation Notice,
a Pay Down Notice or Conversion Notice has been given. 


  

	5.	 The Company undertakes that, while an aggregate principal amount of Notes greater than £10,000,000
remains in issue, it shall not, without prior Noteholder Majority Consent: 


  

	 	(a)	 sell, transfer, lease, licence or otherwise dispose of any material asset or business of any Group Company
(including the sale, transfer or other disposition of a Group Company’s rights to a third party), other than in the ordinary course of business; 


  

	 	(b)	 carry out any merger, reorganisation, restructuring or sale of all or substantially all of the assets and/or
business of any Group Company; 


  

	 	(c)	 effect the liquidation, dissolution, or winding of any Group Company, or the cessation of all or substantially
all of the business of any Group Company; 


  

	 	(d)	 authorise any debt security (the incurrence, or extension of any credit or loan guarantee in respect of any
loan or grant of credit exceeding £800,640.512(save that, for the avoidance of doubt, no Noteholder Majority Consent shall be required for (i) any refinancing, in whole or in part, of any Existing Indebtedness; or (ii) the
subscription by any Qualifying Noteholder (and the issuance by the Company) for any Tranche 2 Notes pursuant to the Securities Purchase Agreement); 


  

	 	(e)	 discontinue any existing line of business of any Group Company or enter into any new line of line of business
by any Group Company; or 


  

	 	(f)	 issue any securities senior to the Ordinary Shares with respect to voting rights, dividends, conversion rights,
redemption rights, liquidation preference or otherwise. 


  

	6.	 Payment of the principal amount and all accrued interest on the Notes may be made by cheque made payable to, or
by bank transfer to an account nominated for the purpose to the Company in writing by, the registered holder or, in the case of joint registered holders, to the one who is first-named on the register, or to such person or persons as the registered
holder or all the joint registered holders may in writing direct and sent to the registered holder or in the case of joint registered holders to that one of the joint registered holders who is first-named on the register or to such




  
 41 














	 	address as the registered holder or joint registered holders may in writing direct. Cheques may be sent through the post at the risk of the registered holder or jointly registered holders and payment of any such cheque
by the bankers on whom it is drawn, or a bank transfer to the relevant account, shall be good discharge to the Company. 

  

	7.	 If more than one person is entered in the register as joint holders of any Notes then, without prejudice to
paragraph 5 of this Part 3 of Schedule 2, the receipt of any one of such holders for any moneys payable on or in respect of the Notes shall be as effective a discharge to the Company or other person making the payment as if the person signing such
receipt were the sole registered holder of such Notes. 


  

	8.	 If any Certificate is worn out or defaced then, on production of it to the Directors, they may cancel it and
may issue a fresh Certificate in lieu. If any Certificate is lost or destroyed it may be replaced on such terms (if any) as to evidence and indemnity as the Company may reasonably require. An entry recording the issue of the new Certificate and
indemnity (if any) shall be made in the register. No fee shall be charged for the registration of any transfer or for the registration of any probate, letters of administration, certificate of marriage or death, power of attorney or other documents
relating to or effecting title to any Notes. 


  

	9.	 Any notice or other document required to be given under this Instrument shall be in writing and may be given to
or served on any Noteholder by sending it by first-class post in a prepaid envelope addressed to such Noteholder at his registered address. In the case of joint Noteholders, a notice given to, or document served on, the Noteholder whose name stands
first in the register in respect of such Notes shall be sufficient notice to, or service on, all the joint holders. Any such notice sent or document served by first-class post shall be deemed to have been given or served 48 hours or 96 hours in the
case of a notice or document sent to an address for a Noteholder not in the United Kingdom after the time when it is posted and in proving such notice or service, it shall be sufficient to prove that the envelope containing the notice or document
was properly addressed, stamped and posted. 


  

	10.	 Any notice or other document delivered or sent by post to, or left at, the registered address of any Noteholder
in pursuance of these provisions shall, notwithstanding that such Noteholder is then dead or bankrupt or in liquidation, and whether or not the Company has notice of his death or bankruptcy or liquidation, be deemed to have been duly served or
delivered in respect of any Notes registered in the name of such Noteholder as sole or first-named joint holder unless his name shall at the time of the service of the notice or document have been removed from the register as the holder of the
Notes, and such service shall for all purposes be deemed sufficient service of such notice or document on all persons interested (whether jointly with or as claiming through or under him) in the Notes. 



  
 42 














	11.	 A copy of this Instrument shall be kept at the Company’s registered office. A Noteholder (and any person
authorised by a Noteholder) may inspect that copy of the Instrument at all reasonable times during office hours. 


  

	12.	 Each Noteholder by subscribing for and/or holding any Notes pursuant to the terms of this Instrument expressly
and irrevocably agrees that the Group Companies may refinance all or any part of either the Senior Loan or the Novartis Loan Note (either with the existing creditors thereof or with third party creditors) and that, such refinanced loan shall for all
purposes under this Instrument be treated, mutatis mutandis ̧ as the Senior Loan or the Novartis Loan Note (as the case may be) and benefit from any protections, provisions, exemptions or other terms hereof, without requiring the consent
of any Noteholder; provided, that no such refinancing or amendment of the Senior Loan which increases the amount of the principal sum of the Senior Loan owing from time to time above £14 million, or extends the Final Repayment Date for
the Senior Loan beyond 1 March 2022, shall be effective unless otherwise approved by the Noteholder Majority; provided, further, that no such consent or agreement shall be required from any Noteholder Majority from or after the time when
Shareholder Approval has been obtained. For the avoidance of doubt, if any such refinancing takes place, any lenders thereunder shall be treated as the “Senior Lenders” for the purposes of this Instrument. The Company shall as soon as
reasonably practicable after the occurrence of any such refinancing, provide notice of the same to the Noteholders. 


  

	13.	 If the Company, whilst any Notes are outstanding, shall effect a subdivision of its Ordinary Shares, the
Tranche 1 Conversion Price and Tranche 2 Conversion Price (if any) then in effect immediately before that subdivision shall be proportionately decreased. If the Company, whilst any Notes are outstanding, shall combine its Ordinary Shares, the
Tranche 1 Conversion Price and Tranche 2 Conversion Price then in effect immediately before the combination shall be proportionately increased. 


  

	14.	 If the Company, whilst any Notes are outstanding, shall make or issue, or fix a record date for the
determination of holders of its Ordinary Shares entitled to receive a dividend or other distribution to the shareholders from the fund for invested unrestricted equity payable in Ordinary Shares in the Company, then and in each such event the
Tranche 1 Conversion Price and Tranche 2 Conversion Price then in effect immediately before such event shall be decreased as of the time of such issuance or, in the event such a record date shall have been fixed, as of the close of business on such
record date, by multiplying the Tranche 1 Conversion Price or Tranche 2 Conversion Price, as applicable, then in effect by a fraction: 



  
 43 














	 	(a)	 the numerator of which shall be the total number of Ordinary Shares outstanding immediately prior to the time
of such issuance or the close of business on such record date, and 


  

	 	(b)	 the denominator of which shall be the total number of Ordinary Shares outstanding immediately prior to the time
of such issuance or the close of business on such record date plus the number of Ordinary Shares issuable in payment of such dividend or distribution; 



provided, however, that if such record date shall have been fixed and such dividend is not fully paid or if such distribution is not fully made
on the date fixed therefor, the Tranche 1 Conversion Price and Tranche 2 Conversion Price shall be recomputed accordingly as of the close of business on such date and thereafter the Tranche 1 Conversion Price and Tranche 2 Conversion Price shall be
adjusted pursuant to this paragraph as of the time of actual payment of such dividends or distributions, if any. 
  

	15.	 When any adjustment is required to be made in the Tranche 1 Conversion Price or Tranche 2 Conversion Price
pursuant to paragraph 14 or 15, the number of Ordinary Shares issuable upon conversion of a Note shall be calculated by reference to the revised Tranche 1 Conversion Price or Tranche 2 Conversion price following the adjustment made by paragraph 14
or 15. 


  

	16.	 If the Company, whilst any Notes are outstanding, shall: (i) pay or declare a dividend payable to all
shareholders other than in Ordinary Shares (e.g. in cash or assets other than Ordinary Shares in the Company); or (ii) make any distribution of share capital (including share premium account and capital redemption legal reserve), then and in
each such event the Tranche 1 Conversion Price and Tranche 2 Conversion Price then in effect immediately before such event shall be decreased as of such event by multiplying the Tranche 1 Conversion Price or Tranche 2 Conversion Price, as
applicable, then in effect by a fraction: 


  

	 	(a)	 the numerator of which shall be equal to (i) the Closing Price on the day immediately prior to the date
when such event was first published (or if there is no such price, the fair market value of one ordinary share of the Company as of such date as determined in good faith by the Directors) minus (ii) the amount per issued share of such dividend
or distribution; and 



  
 44 














	 	(b)	 the denominator of which shall be the Closing Price on the day immediately prior to the date when such event
was first published (or if there is no such price, the fair market value of one ordinary share of the Company as of such date as determined in good faith by the Directors). 



In the event that the application of the above fraction would result in an increase in the Conversion Price, then no adjustment shall be made
hereunder. If the Company distributes assets other than cash, the amount per outstanding share of the distribution shall be calculated by reference to the fair market value of the assets distributed as determined in good faith by the Directors. 

“Closing Price” for purposes of this
paragraph means: the most recently reported closing price of the Ordinary Shares on AIM. 
  

	17.	 If, prior to the Maturity Date, there shall occur any reorganization, recapitalization, reclassification,
consolidation, merger or demerger involving the Company in which the Company’s Ordinary Shares are converted into or exchanged for securities, cash or other property (other than a transaction covered by paragraphs 14 or 15) (collectively, a
“Reorganization”), then, following such Reorganization, the Noteholders shall receive upon conversion the kind and amount of securities, cash or other property, if any, which the Noteholders would have been entitled to receive
pursuant to such Reorganization if such conversion had taken place immediately prior to such Reorganization. Appropriate adjustment (as determined in good faith by the Directors) shall be made in the application of the provisions set forth herein
with respect to the rights and interests thereafter of the Noteholder, to the end that the provisions set forth in this Instrument (including provisions with respect to changes in and other adjustments of the Tranche 1 Conversion Price and/or
Tranche 2 Conversion Price (as applicable) and the number of Ordinary Shares issuable upon conversion of the Notes) shall thereafter be applicable, as nearly as reasonably may be, in relation to any securities, cash or other property thereafter
deliverable upon the conversion of the Notes. 



  
 45 














Part 4. ADS
Issuance
and
Delivery Instruction 

[DATE] 

Citibank, N.A., as
Depositary 

388 Greenwich
Street 

New York, New York
10013 

Attn.: Mr. Brian M.
Teitelbaum (brian.m.teitelbaum@citi.com) 
 With a copy simultaneously delivered to: 

Citibank, N.A., London
Branch 

25 Canada Square 

Canary Wharf 

London E14 5LB,
England 

Attn.: UK Custody
Settlements 

Custody Team
(uksettlements@citi.com) 
 Re: Issuance and Delivery Instruction—Mereo BioPharma Group plc (CUSIP No.: 589492107) – Deposit &
Hold 

Dear Sirs: 

Reference is
made to the Deposit Agreement, dated as of April 23, 2018, as amended and supplemented from time to time (the “Deposit Agreement”), by and among Mereo BioPharma Group plc, a public limited company incorporated under the laws of
England and Wales and its successors (the “Company”), Citibank, N.A., a national banking association organized and existing under the laws of the United States of America, as Depositary (the “Depositary”), and all Holders and
Beneficial Owners of American Depositary Shares (the “ADSs”) issued thereunder. All capitalized terms used, but not otherwise defined herein, shall have the meaning assigned thereto in the Deposit Agreement. 

In
accordance with the terms and subject to the limitations set forth in the Deposit Agreement, promptly following the Depositary’s receipt of confirmation from the Custodian that the Custodian has received a deposit of the number of Shares
specified below made by the Company for the benefit of the undersigned holder thereof (the “Holder” and together with the Company, the “Undersigned”), the Undersigned hereby jointly instruct the Depositary, and the Depositary
hereby agrees: 

  
 46 














(i) to
promptly accept for deposit the number of Shares and issue the number of ADSs as specified below: 
  

			
	Number of Shares deposited:	  	Shares


Number of ADSs (CUSIP No.:
589492107; each ADS representing five (5) Shares to be issued: 
 ADSs 
 and (ii) to promptly deliver such Program ADSs, as follows:

 Name of DTC
Participant to which the ADSs are to be delivered:  
 DTC Participant Account No.:  

Account No. for recipient of
ADSs at DTC Participant (f/b/o/ information):  
 Name on whose behalf the above number of ADSs are to be issued and delivered:  

Contact person at DTC
Participant: Daytime telephone number of contact person at DTC:  
 The Company hereby confirms and certifies that (i) the registration statement on Form F-3 (File No. 333-239708)
(the “Registration Statement”), filed with the U.S. Securities and Exchange Commission (the “Commission”) on July 6, 2020, registers the resale of the above Shares represented by ADSs, such ADSs will be freely transferable
following the issuance thereof by the Depositary, and there are no legal restrictions on subsequent transfers of the ADSs to be issued hereunder under the laws of England and Wales or the United States, (ii) the Registration Statement is
effective under the Securities Act of 1933, as amended (the “Securities Act”), and (iii) no stop order suspending the effectiveness of the Registration Statement has been issued and no proceedings for such purpose have been instituted
or are pending or, to the best knowledge of the Company, are contemplated or threatened by the Commission. 

The Holder hereby represents
and covenants to, and for the benefit of, the Depositary and Citibank, N.A.—London Branch (the “Custodian”), that (i) the Holder is not an “affiliate” of the Company as that term is defined in Rule 144 promulgated by
the Commission under the Securities Act and has not been an affiliate at any time during the 90 days immediately preceding the date hereof, and (ii) all stamp duty taxes, including, without limitation, the U.K. Stamp Duty Reserve Tax
(“SDRT”), will be paid in full and on a timely basis to the extent such taxes are payable in respect of the deposit of the Shares and the issuance and delivery of the ADSs as contemplated herein. 

  
 47 














Each of the Holder and, to
the extent it is not unlawful for the Company to do so under the applicable laws of England and Wales, the Company agrees to indemnify the Depositary and the Custodian for, and to hold the Depositary and the Custodian harmless against, all losses,
liabilities, taxes, charges, penalties or expenses (including reasonable legal fees and disbursements), incurred by the Depositary and/or by the Custodian or to which the Depositary and/or the Custodian may become subject to and arising directly or
indirectly from the failure by any person to pay (or discharge) any applicable stamp duty taxes, including, without limitation, SDRT, or any other similar duty or tax in connection with the deposit of the Shares and the issuance and delivery of the
ADSs as contemplated herein, save to the extent that such losses, liabilities, taxes, charges, penalties or expenses are due to the negligence or bad faith of the Custodian or the Depositary.

  

			
	[HOLDER]	  	MEREO BIOPHARMA GROUP PLC
		
	By:	  	By:
	Name:	  	Name:
	Title:	  	Title:


  
 48 













 Schedule 3 Meetings of the Noteholders 

 

	1.	 The Company may at any time convene a meeting of Noteholders. In addition, the Company shall at the written
request of the holders of not less than one-quarter (25%) in nominal amount of the outstanding Notes convene a meeting of the Noteholders. Any meeting shall be held at such place as the Company may designate. 



 

	2.	 At least 14 days’ notice (exclusive of the day on which the notice is served or deemed to be served and of
the day for which notice is given) of every meeting shall be given to the Noteholders. The notice shall specify the place, day and time of the meeting and the general nature of the business to be transacted, but it shall not be necessary (except in
the case of a Special Resolution) to specify in the notice the terms of any resolution to be proposed. The accidental omission to give notice to, or the non-receipt of notice by, any of the Noteholders shall not invalidate the proceedings at any
meeting. A meeting of the Noteholders shall, despite being called at shorter notice than specified above, be deemed to have been duly called if it is agreed in writing by all of the Noteholders. 



 

	3.	 At any meeting the quorum shall be two or more Noteholders holding, or representing by proxy, at least 50.1% in
nominal principal amount of the outstanding Notes. No business (other than choosing a Chairman) shall be transacted at any meeting unless the requisite quorum is present. 



 

	4.	 If a quorum is not present, within half an hour from the time appointed for the meeting, the meeting shall be
dissolved if it was convened on the requisition of Noteholders. In any other case, it shall stand adjourned to such day and time (at least 14 days later, but not more than 28 days later) and to such place as may be appointed by the Chairman. At such
adjourned meeting, two Noteholders present in person (or by proxy) and entitled to vote shall constitute a quorum (whatever the nominal amount of the Notes held by them). At least 14 days’ notice of any adjourned meeting of Noteholders shall be
given (in the same manner mutatis mutandis as for an original meeting). That notice shall state that two Noteholders present in person (or by proxy) at the adjourned meeting (whatever the nominal amount of Notes held by them) shall form a quorum.




  
 49 














	5.	 A person (who may but need not be a Noteholder) nominated by the Company shall be entitled to take the chair at
every such meeting but, if no such person is nominated or if the person nominated is not be present at the meeting within five minutes after the time appointed for holding the meeting, the Noteholders present shall choose one of their number to be
Chairman. Any Director or officer of, any Secretary of, and the solicitors to, the Company and any other person authorised in that behalf by the Company may attend at any such meeting. 



 

	6.	 Each question submitted to a meeting of Noteholders shall, unless a poll is demanded, be decided by a show of
hands. 


  

	7.	 At any meeting of Noteholders unless a poll is demanded by the Chairman or by one or more Noteholders present
in person or by proxy and holding or representing in the aggregate not less than one-twentieth in nominal amount of the outstanding Notes (before or on the declaration of the result of the show of hands), a declaration by the Chairman that a
resolution has been carried by the requisite majority, lost or not carried by the requisite majority shall be conclusive evidence of the fact, without proof of the number or proportion of the votes recorded in favour of or against such resolution.



  

	8.	 If a poll is duly demanded, it shall be taken in such manner and (subject as set out below) either at once or
after an adjournment as the Chairman directs. The result of the poll shall be deemed to be the resolution of the meeting at which the poll was demanded. The demand for a poll shall not prevent the meeting from continuing for the transaction of any
business other than the question on which the poll has been demanded. The demand for a poll may be withdrawn. 


  

	9.	 If there is an equality of votes, whether on a show of hands or on a poll, the Chairman of the meeting shall
not be entitled to a casting vote in addition to the vote(s) (if any) to which he may be entitled as a Noteholder or as a proxy. 


  

	10.	 The Chairman may, with the consent of (and shall if so directed by) any meeting at which a quorum is present,
adjourn the meeting from time to time and from place to place, but no business shall be transacted at any adjourned meeting except business that might lawfully have been transacted at the meeting from which the adjournment took place.



  

	11.	 Any poll demanded at any meeting on the election of a Chairman, or on any question of adjournment, shall be
taken at the meeting without adjournment. 



  
 50 














	12.	 On a show of hands, each Noteholder who is an individual and is present in person or (being a corporation) is
present by its duly authorised representative or by one of its officers as its proxy, shall have one vote. On a poll, each Noteholder present in person or by proxy, shall have one vote for every £1 nominal principal amount of Notes held by him
and a person entitled to more than one vote need not (if he votes) use all his votes or cast all the votes he uses in the same way. 


  

	13.	 In the case of joint registered Noteholders any one of them shall be entitled to vote in respect of such Notes
either in person or by proxy and, in the latter case, as if the joint holder were solely entitled to such Notes. If more than one joint holder is present at any meeting either personally or by proxy that one joint holder so present whose name as
between himself and the other or others present stands first in the register as one of the joint holders shall alone be entitled to vote in person or by proxy. 



 

	14.	 Each instrument appointing a proxy must be in writing and duly executed by the appointor or his duly authorised
attorney or, in the case of a corporation under its common seal or duly executed by a duly authorised attorney or officer. The Chairman may (but shall not be bound to) require evidence of the authority of any attorney or officer. A proxy need not be
a Noteholder. 


  

	15.	 An instrument of proxy shall be in the usual or common form or in any other form that the Directors may accept.
The proxy shall be deemed to include the right to demand or join in demanding a poll. A proxy shall, unless stated otherwise, be valid as well for any adjournment of the meeting as for the meeting to which it relates and need not be witnessed.



  

	16.	 The instrument appointing a proxy, and the power of attorney or other authority (if any) under which it is
signed or a notarially certified copy of such power of attorney or authority, shall be deposited at the place specified in (or in any document accompanying) the notice convening the meeting. If no such place is specified, the proxy shall be
deposited at the registered office of the Company not less than 48 hours before the time appointed for holding the meeting or adjourned meeting or for taking of the poll at which the person named in that instrument proposes to vote. In default, the
instrument of proxy shall not be treated as valid. A vote given in accordance with the terms of an instrument of proxy shall be valid notwithstanding the revocation of the proxy or of the authority under which the proxy is given, unless notification
in writing of the revocation has been received at the registered office of the Company or at such other place (if any) specified for the deposit of instruments of proxy in the notice convening the meeting (or any document accompanying it) 48 hours
before the commencement of the meeting or adjourned meeting or the taking of the poll at which the vote is given. 



  
 51 














	17.	 Without prejudice to any of the powers conferred on the Company under any of the provisions of the Instrument,
a meeting of the Noteholders shall, in addition to any other powers, have the following powers exercisable by Special Resolution: 


  

	 	(a)	 power to sanction the exchange or sale of the Notes for, or the conversion of the Notes into, or the
cancellation of the Notes in consideration of, shares, stock, debenture stock or other obligations or security of the Company or any other company formed or to be formed (provided, in each of the foregoing cases, that such action will be conducted
in accordance with the terms of the Conditions or with the prior written consent of the Company); 


  

	 	(b)	 power to sanction any abrogation, modification or compromise of, or any arrangement in respect of, the
Noteholders’ rights against the Company, provided the same has been previously approved in writing by the Company, whether those rights shall arise under the Instrument, the Notes or otherwise; 



 

	 	(c)	 power to assent to any modification of the provisions contained in the Instrument and the Conditions and to
authorise the Company to execute any supplemental instrument embodying any such modification. Any such modification shall be proposed by the Company; and 


  

	 	(d)	 with the prior written consent of the Company, power to: 



 

	 	(i)	 modify the date fixed for final redemption of the Notes; 



 

	 	(ii)	 reduce or cancel the principal amount payable on the Notes; 



 

	 	(iii)	 reduce the amount payable or modify the method of calculating the amount payable on the Notes; or



  

	 	(iv)	 modify the dates for payment in respect of any interest, on the Notes. 



 

	18.	 A Special Resolution passed at a meeting of the Noteholders shall be binding on all the Noteholders whether or
not they are present at the meeting. Each of the Noteholders shall be bound to give effect to it accordingly. The passing of any such resolution shall be conclusive evidence that the circumstances justify passing it (so that the meeting may
determine without appeal whether or not the circumstances justify passing it). 



  
 52 














	19.	 Special Resolution, when used in the Conditions, means a resolution passed at a meeting of the
Noteholders duly convened and held in accordance with the Conditions, and carried by a Noteholder Majority. 


  

	20.	 A resolution in writing signed by or on behalf of a Noteholder Majority shall, for all purposes, be as valid
and effectual as a Special Resolution passed at a meeting duly convened and held in accordance with the Conditions. Such resolution in writing may be contained in one document or in several documents in similar form, each signed by one or more
Noteholders. 


  

	21.	 Minutes of all resolutions and proceedings at every meeting shall be made and duly entered in books to be from
time to time provided for that purpose by the Company. Any minutes, if purporting to be signed by the Chairman of the meeting or by the Chairman of the next succeeding meeting of the Noteholders, shall be conclusive evidence of the matters stated in
them. Until the contrary is proved, every meeting for which minutes have been made and signed shall be deemed to have been duly held and convened, and all resolutions passed at the meeting to have been duly passed. 



  
 53 













 EXECUTED as a DEED by MEREO BIOPHARMA GROUP PLC 

acting by 
  

 
 Director/Authorised signatory 

 
  

Director/Authorised signatory 
  

			
		
	______________________	 	  

		
	Witness	 	
		
	Name:	 	  

		
	Address:	 	  

		
		 	  

		
	Occupation:	 	  



  
 54 













 SCHEDULE 2 

AMENDED NOTE INSTRUMENT (CLEAN COPY) 

  
 7 













 THIS INSTRUMENT AND THE SECURITIES ISSUABLE UPON THE CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”). THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT OR PURSUANT TO AN APPLICABLE
EXEMPTION THEREFROM. 

DATED                
DECEMBER 2020 
 AMENDED CONVERTIBLE LOAN NOTE
INSTRUMENT DATED 3 JUNE 2020 
 RELATING TO 

MEREO BIOPHARMA GROUP PLC 

  
 1 













 CONTENTS 
  

							
			
	1.	 	Interpretation	  	 	4	 
			
	2.	 	Amount and description of notes	  	 	11	 
			
	3.	 	Status of notes	  	 	11	 
			
	4.	 	Use of Proceeds	  	 	13	 
			
	5.	 	Repayment of Notes	  	 	13	 
			
	6.	 	Interest	  	 	13	 
			
	7.	 	Certificates	  	 	13	 
			
	8.	 	The Register	  	 	14	 
			
	9.	 	Notes not to be quoted	  	 	15	 
			
	10.	 	Set-off	  	 	15	 
			
	11.	 	Meetings of Noteholders	  	 	15	 
			
	12.	 	Variation	  	 	15	 
			
	13.	 	Enforcement and third party rights	  	 	16	 
			
	14.	 	Notices	  	 	16	 
			
	15.	 	Governing law and jurisdiction	  	 	16	 
		
	SCHEDULE 1	  	 	18	 
		
	Part 1. - Form of Tranche 1 Note Certificate	  	 	18	 
		
	Part 2. - Form of Tranche 2 Note Certificate	  	 	20	 
		
	Part 3. - Form of Tranche 3 Note Certificate	  	 	22	 
		
	SCHEDULE 2     THE CONDITIONS	  	 	24	 
		
	Part 1. Interest, repayment and redemption	  	 	24	 
			
	1.	 	Interest	  	 	24	 
			
	2.	 	Repayment of principal	  	 	25	 
			
	3.	 	Time of payment	  	 	27	 
			
	4.	 	Redemption	  	 	27	 
			
	5.	 	Events of Default	  	 	33	 
			
	6.	 	Action following Event of Default	  	 	34	 
			
	7.	 	Taxation	  	 	34	 
		
	Part 2. Conversion	  	 	36	 
			
	1.	 	Conversion	  	 	36	 
			
	2.	 	Procedures on conversion	  	 	38	 
		
	Part 3. Transfer provisions, Undertakings and other matters	  	 	40	 
		
	Part 4. ADS Issuance and Delivery Instruction	  	 	46	 
		
	SCHEDULE 3     MEETINGS OF THE NOTEHOLDERS	  	 	49	 


  
 2 













 THIS INSTRUMENT is made as a deed poll on 3 June 2020 and as amended on 9 June 2020 and
     December 2020. 
 BY 

MEREO BIOPHARMA GROUP PLC incorporated and registered in England and Wales with company number 09481161 whose registered office is at 4th Floor, 1
Cavendish Place, London W1G 0QF, United Kingdom (the “Company”). 
 WHEREAS: 

 

	A.	 On 3 June 2020 the Company entered into certain financing transactions, pursuant to which OrbiMed
Partners Master Fund Limited, OrbiMed Genesis Master Fund L.P. and OrbiMed Private Investments VII, LP (the “Lead Investors”) and certain other investors (the “Investors”) subscribed for the following securities of
the Company: (x) a unit (referred to for convenience as “Ordinary Units”), consisting of (i) one ordinary share of the Company with a nominal value of £0.003 per share (such class of shares, the
“Ordinary Shares,” and all such shares to be issued to the Purchasers, the “Shares”) together with (ii) one warrant to subscribe for 0.50 Ordinary Shares (all such warrants to be issued to the
Purchasers, the “Ordinary Warrants”), at a purchase price of £0.174 per Unit and (y) a unit (referred to for convenience as the “Convertible Units”) consisting of (i) one Note together with
(ii) warrants to subscribe for a number of Ordinary Shares equal to 0.5 times the number of Ordinary Shares issuable upon conversion of each Note (all such warrants to be issued to the Purchasers, the “Note Warrants” and
together with the Ordinary Warrants (the “Warrants”) (the issuance of the foregoing Ordinary Units and Convertible Units collectively , the “Transaction”). 



 

	B.	 By exercise of the powers conferred on them by the Articles, the Directors of the Company have, by a
resolution passed on 1 June 2020, resolved to create, and to constitute the Notes hereunder. 


  

	C.	 This Instrument constitutes the Notes. 



 

	D.	 The Company and its subsidiaries are parties to an existing senior secured loan agreement in the
principal amount of £20,455,000 with Silicon Valley Bank (as lender) (“SVB”) and Kreos Capital V (UK) Limited (as lender, agent and security agent) (“Kreos”), dated 28 September 2018 (as updated and
amended from time to time) (the “Senior Loan”). 


  

	E.	 The Notes created hereunder shall be subordinated to the Senior Loan by entry into a separate
subordination deed between the Noteholders, Kreos and SVB on or around the date hereof (the “Subordination Agreement”). 



  
 3 













 AGREED TERMS 

 

	1.	 INTERPRETATION 



 

	1.1	 The definitions and rules of interpretation in this clause apply in this Instrument. 



 

	1.2	 Acceleration Date: has the meaning given in paragraph 4 of Part 1 of Schedule 2. 



ADS: has the meaning given in the Securities Purchase Agreement. 

ADS Exchange Ratio: means the ratio applicable to the exchange of Ordinary Shares for ADSs from time to time, currently being a ratio of
5 Ordinary Shares for each ADS. 
 Affiliate: means a person that owns or controls directly or indirectly another person, any
person that controls or is controlled by or is under common control with the person, including, without limitation, any subsidiaries, and any of that person’s general or limited partners, senior executive officers, directors and, for any person
that is a limited liability company, that person’s managers and members or any venture capital fund or registered investment company now or hereafter existing that is controlled by one or more general partners or managing members or investment
advisor of, or shares the same management company or investors advisor (or member thereof) with, such person. 
 Alternative Warrant
Conversion Notice: has the meaning given in the Securities Purchase Agreement. 
 Articles: means the articles of association of
the Company, as amended or superseded. 
 Business Day: means any day other than Saturday, Sunday or federal legal holiday in the
United States of America, or public holiday or bank holiday in the United Kingdom. 
 Certificate: means a Tranche 1 Note
Certificate, a Tranche 2 Note Certificate or a Tranche 3 Note Certificate, as applicable. 
 Change of Control: means,
(a) in one transaction or a series of related transactions, a person or one or more persons acting in concert, acquiring (i) all (or substantially all) of the share capital or assets of the Company, or (ii) more than fifty percent
(50%) of the outstanding equity or other securities of the Company; or (b) any merger, consolidation, reorganisation, or business combination as a result of which the majority equity or other security holders of the Company immediately
preceding such transaction (s) hold less than fifty percent (50%) of the outstanding voting power, respectively, of the ultimate company or entity resulting from such transaction(s) 

  
 4 













 
immediately after consummation of such transaction. In the foregoing case, “acting in concert” means a group of persons who, pursuant to an agreement or understanding (whether formal or
informal), actively co-operate, through the acquisition and/or ownership of voting shares in the Company, to obtain or consolidate control (directly or indirectly) of the Company provided that the persons voting in the same or consistent manner at
any general meeting of the Company will not be considered to be acting in concert by virtue only of exercising their votes in such manner. 

Change of Control Payment: has the meaning given in paragraph 4.12 of Part 1 of Schedule 2. 

Closing Price: means: (i) if at the relevant time the Ordinary Shares continue to be admitted to trading on AIM, the most recently
reported closing price of one Ordinary Share on AIM; or (ii) if at the relevant time the Shares are no longer admitted to trading on AIM, the implied price of one Ordinary Share in pounds sterling by reference to the most recently reported
closing price of an ADS on Nasdaq. 
 Conditions: means the conditions attaching to the Notes, as set out in Schedule 2 (as
amended from time to time in accordance with this Instrument). 
 Conversion Date: means (i) in the case of Tranche 1 Notes being
converted automatically following Shareholder Approval pursuant to the provisions of paragraph 1.2 of Part 2 of Schedule 2, the date on which such Shareholder Approval is granted; and/or (ii), in the case of an Uplift Notice or Pay Down Notice, the
date specified in such notice; and/or (iii) in all other cases, the date falling 5 Business Days after service of the Conversion Notice. 

Conversion Notice: means a notice in writing served by a Noteholder to the Company to convert all or, if the Ownership Limit applies,
some of its outstanding Notes. 
 Default Rate: means the Tranche 1 Default Rate, Tranche 2 Default Rate or Tranche 3 Default Rate (as
applicable). 
 Depositary: has the meaning given in the Securities Purchase Agreement. 

Directors: means the board of directors of the Company, or a duly authorised committee of that board, for the time being. 

Effective Date: means the date of this Deed. 

Event of Default: means any of the events set out in paragraph 5 of Part 1 of Schedule 2. 

Existing Indebtedness: means any indebtedness incurred by a Group Company and outstanding on or prior to the Effective Date (which for
the avoidance of doubt shall include indebtedness pursuant to the Senior Loan and the Novartis Loan Note). 

  
 5 













 Group Company: means each of the Company and its subsidiaries.  

Interest Rate: has the meaning given in paragraph 1 of Part 1 of Schedule 2.  

Kreos: has the meaning given in the recitals of this Instrument. 

Lead Investors: has the meaning given in the recitals of this Instrument. 

Nasdaq: means the Nasdaq Global Market or the Nasdaq Capital Market (as applicable). 

Notes: means the Tranche 1 Notes, the Tranche 2 Notes or the Tranche 3 Notes, as applicable. 

Noteholder: means a person for the time being entered in the Register as holder of any Notes. 

Noteholder Majority: means Noteholders holding more than 50% of the principal amount of all outstanding Notes. 

Noteholder Majority Consent: means the consent of a Noteholder Majority provided either at a meeting of Noteholders or in writing, in
each case in accordance with the requirements of Schedule 3. 
 Novartis: means Novartis Pharma AG, a company incorporated
under the laws of Switzerland. 
 Novartis Loan Note: means the convertible loan note originally issued by the Company
to Novartis in the principal amount of £3,841,479 on 8 February 2020. 
 Ordinary Shares: means the ordinary shares
of £0.003 each in the capital of the Company, which have the rights set out in the Articles. 
 Original Warrantholder: has the
meaning given in the Securities Purchase Agreement. 
 Ownership Limit: has the meaning given in paragraph 1.2 of Part 2 of Schedule
2. 
 Pay Down Issue: has the meaning given in paragraph 4.7 of Part 1 of Schedule 2.  

Pay Down Notice: has the meaning given in paragraph 4.7 of Part 1 of Schedule 2. 

Pay Down Securities: has the meaning given in paragraph 4.7 of Part 1 of Schedule 2. 

Pay Down Reduction Amount: has the meaning given in paragraph 4.8 of Part 1 of Schedule 2. 

Qualifying Noteholder: means any Noteholder holding Notes with a principal amount of £6,004,803.84 or greater. 

Redemption Date: has the meaning given in paragraph 4.1 of Part 1 of Schedule 2. 

  
 6 













 Redemption Notice: has the meaning given in paragraph 4.13 of Part 1 of Schedule 2.

 Register: means a register of Noteholders referred to in, and kept and maintained in accordance with, clause 8. 

Registered Office: means the registered office of the Company from time to time. 

Securities Purchase Agreement: means the agreement governing the purchase of Ordinary Shares comprising the Transaction among,
inter alios, the Company, the Lead Investors and the other Investors party thereto, dated on or around the date hereof. 

Senior Lenders: means SVB and Kreos (and each of them individually, a “Senior Lender”) and/or their respective
successors in title. 
 Senior Loan: has the meaning given in the recitals of this Instrument. 

Shareholder Approval: has the meaning given in the Securities Purchase Agreement. 

Shareholders Meeting: has the meaning given in the Securities Purchase Agreement. 

Shares: has the meaning given in the recitals of this Instrument. 

Subordination Agreement: has the meaning given in the recitals of this Instrument. 

SVB: has the meaning given in the recitals of this Instrument. 

Tranche 1 Conversion Price: £0.174 per Ordinary Share, subject to adjustment as set forth in Part 3 of Schedule 2. 

Tranche 2 Conversion Price: £0.348 per Ordinary Share, subject to adjustment as set forth in Part 3 of Schedule 2. 

Tranche 1 Default Rate: has the meaning given in paragraph 1.1 of Part 1 of Schedule 2. 

Tranche 2 Default Rate: has the meaning given in paragraph 1.2 of Part 1 of Schedule 2. 

Tranche 3 Default Rate: has the meaning given in paragraph 1.3 of Part 1 of Schedule 2. 

Tranche 1 Extension Option: has the meaning given in paragraph 2.3 of Part 1 of Schedule 2. 

Tranche 1 Extension Notice: has the meaning given in paragraph 2.3 of Part 1 of Schedule 2. 

Tranche 2 Extension Option: has the meaning given in paragraph 2.5 of Part 1 of Schedule 2. 

  
 7 













 Tranche 2 Extension Notice: has the meaning given in paragraph 2.5 of Part 1 of
Schedule 2. 
 Tranche 3 Extension Option: has the meaning given in paragraph 2.7 of Part 1 of Schedule 2. 

Tranche 3 Extension Notice: has the meaning given in paragraph 2.7 of Part 1 of Schedule 2. 

Tranche 1 Maturity Date: means 3 June 2023 or, in respect of any Tranche 1 Notes held by a Qualifying Noteholder, such later date
as may be applicable following exercise of the Tranche 1 Extension Option. 
 Tranche 2 Maturity Date: means the date falling
three years from the date of issue of such Tranche 2 Notes, or in respect of any Tranche 2 Notes held by a Qualifying Noteholder, such later date as may be applicable following exercise of the Tranche 2 Extension Option. 

Tranche 3 Maturity Date: means 3 June 2025 or, in respect of any Tranche 3 Notes held by a Qualifying Noteholder, such later date
as may be applicable following exercise of the Tranche 3 Extension Option and acceptance by the Company of the same. 
 Tranche 1 Note
Certificate: a certificate for Tranche 1 Notes in the form (or substantially in the form) set out in Part 1 of Schedule 1. 
 Tranche
2 Note Certificate: a certificate for Tranche 2 Notes in the form (or substantially in the form) set out in Part 2 of Schedule 1. 

Tranche 3 Note Certificate: a certificate for Tranche 3 Notes in the form (or substantially in the form) set out in Part 3 of Schedule
1. 
 Tranche 1 Noteholder: means a Noteholder holding Tranche 1 Notes.  

Tranche 2 Noteholder: means a Noteholder holding Tranche 2 Notes.  

Tranche 3 Noteholder: means a Noteholder holding Tranche 3 Notes. 

Tranche 1 Notes: up to £40,533,671 in aggregate unsecured convertible loan notes of £1 principal amount each,
maturing on the Tranche 1 Maturity Date constituted by this Instrument or, as the case may be, the principal amount of such loan notes for the time being issued and outstanding, and principal amount shall be construed accordingly. 

Tranche 2 Notes: up to £40,032,025 in aggregate unsecured convertible loan notes of £1 principal amount each,
maturing on the Tranche 2 Maturity Date constituted by this Instrument or, as the case may be, the principal amount of such loan notes for the time being issued and outstanding, and principal amount shall be construed accordingly. 

  
 8 













 Tranche 3 Notes: up to £56,044,831 in aggregate unsecured loan notes of
£1 principal amount each, maturing on the Tranche 3 Maturity Date constituted by this Instrument or, as the case may be, the principal amount of such loan notes for the time being issued and outstanding, and principal amount shall be
construed accordingly. 
 Transaction: has the meaning given in the recitals of this Instrument. 

Uplift Allocation Notice: has the meaning given in paragraph 4.3 of part 1 of Schedule 2. 

Uplift Reduction Amount: has the meaning given in paragraph 4.4 of part 1 of Schedule 2. 

Uplift Securities: has the meaning given in paragraph 4.3 of part 1 of Schedule 2. 

Warrant: has the meaning given in the recitals of this Instrument. 

Warrant Instrument: means the instrument constituting the Warrants dated on or about the Effective Date. 

 

	1.3	 Clause, Schedule and paragraph headings shall not affect the interpretation of this Instrument.



  

	1.4	 References to clauses and Schedules are to the clauses of and Schedules to this Instrument and references to
paragraphs are to paragraphs of the relevant Schedule. 


  

	1.5	 The Schedules (including, for the avoidance of doubt, the Conditions) form part of this Instrument and shall
have effect as if set out in full in the body of this Instrument. Any reference to this Instrument includes the Schedules. 


  

	1.6	 A reference to this Instrument, the Conditions or to any other agreement or document referred to
in this Instrument or the Conditions is a reference to this Instrument (which shall include the Conditions), the Conditions or such other agreement or document as varied or novated in accordance with their terms from time to time.



  

	1.7	 Unless the context otherwise requires, words in the singular shall include the plural and in the plural shall
include the singular. 


  

	1.8	 Unless the context otherwise requires, a reference to one gender shall include a reference to the other
genders. 



  
 9 














	1.9	 A person includes a natural person, corporate or unincorporated body (whether or not having separate
legal personality) and that person’s personal representatives, successors and permitted assigns. 


  

	1.10	 A reference to a company shall include any company, corporation or other body corporate, wherever and
however incorporated or established. 


  

	1.11	 A reference to a holding company or a subsidiary means a holding company or a subsidiary (as the
case may be) as defined in section 1159 of the Companies Act 2006. 


  

	1.12	 A reference to writing or written includes fax but not e-mail (unless otherwise expressly
provided in this Instrument). 


  

	1.13	 Any words following the terms including, include, in particular, for example or any
similar expression shall be construed as illustrative and shall not limit the sense of the words, description, definition, phrase or term preceding those terms. 



 

	1.14	 Where the context permits, other and otherwise are illustrative and shall not limit the sense of
the words preceding them. 


  

	1.15	 A reference to a statute or statutory provision is a reference to it as amended, extended or re-enacted from
time to time. 


  

	1.16	 A reference to a statute or statutory provision shall include all subordinate legislation made from time to
time under that statute or statutory provision. 


  

	1.17	 Any obligation on a person not to do something includes an obligation not to allow that thing to be done.



  

	1.18	 A reference in this Instrument to: 



 

	 	(a)	 any Notes being outstanding means such Notes as are in issue, not redeemed, not converted and not
cancelled at the relevant time; 


  

	 	(b)	 the assets of any person shall be construed as a reference to all or any part of its business,
undertaking, property, assets, revenues (including any right to receive revenues) and uncalled capital; 



  
 10 














	 	(c)	 indebtedness shall be construed as a reference to any obligation for the payment or repayment of money,
whether as principal or as surety and whether present or future, actual or contingent; 


  

	 	(d)	 repayment includes redemption and vice versa and the words repay, redeem, repayable, redeemed and
repaid shall be construed accordingly; 


  

	 	(e)	 $ or USD denotes the lawful currency of the United States of America; 



 

	 	(f)	 £ or sterling denotes the lawful currency of the United Kingdom; and 



 

	 	(g)	 tax shall be construed so as to include any present and future tax, levy, impost, deduction,
withholding, duty or other charge of a similar nature (including, without limitation, any penalty or interest payable in connection with any failure to pay or any delay in paying any of the same). 



 

	1.19	 Unless the context otherwise requires, a reference to the Notes includes a reference to all and/or any
of the Notes. 


  

	2.	 AMOUNT AND DESCRIPTION OF NOTES



  

	2.1	 The aggregate principal amount of the Tranche 1 Notes is limited to £40,533,671. 



 

	2.2	 The aggregate principal amount of the Tranche 2 Notes is limited to £40,032,025. 



 

	2.3	 The aggregate principal amount of the Tranche 3 Notes is limited to £56,044,831. 



 

	2.4	 The Tranche 1 Notes shall be known as the unsecured convertible loan notes due 2023 and shall be issued by the
Company in integral multiples of £1. 


  

	2.5	 The Tranche 2 Notes shall be known as the unsecured convertible loan notes due 2026 and shall be issued by the
Company in integral multiples of £1. 


  

	2.6	 The Tranche 3 Notes shall be known as the unsecured loan notes due 2025 and shall be issued by the Company in
integral multiples of £1. 


  

	3.	 STATUS OF NOTES 



 

	3.1	 The Notes when issued and outstanding shall rank pari passu, equally and rateably, without discrimination or
preference among themselves and as unsecured obligations of the Company. 



  
 11 














	3.2	 The Notes shall be issued and held subject to and with the benefit of the provisions of this Instrument
(including the Conditions). All such provisions shall be binding on the Company and the Noteholders and all persons claiming through or under them respectively and shall enure for the benefit of all Noteholders. 



 

	3.3	 No Notes shall be issued or deemed issued pursuant to this Instrument until Closing (as defined in the
Securities Purchase Agreement) has occurred in accordance with the terms and conditions of the Securities Purchase Agreement. 


  

	3.4	 No Tranche 2 Notes shall be issued to any person who is not a Qualifying Noteholder and has not served upon the
Company an Optional Warrant Conversion Notice (as defined in the Securities Purchase Agreement) in accordance with the provisions of section 5(h)(ii) of the Securities Purchase Agreement. 



 

	3.5	 Any Qualifying Noteholder who delivers an Optional Warrant Conversion Notice (as defined in the Securities
Purchase Agreement) in accordance with the provisions of Clause section 5(h)(ii) of the Securities Purchase Agreement shall have the subscription monies paid to the Company thereunder applied towards the subscription price for Tranche 2 Notes (in
the face amount of £1 for each Tranche 2 Note issued) in accordance with section 5(h)(ii) of the Securities Purchase Agreement. The subscription price in respect of all Warrants subject to the Optional Warrant Conversion Notice shall be
aggregated for purposes of determining the number of Tranche 2 Notes issued, provided that no Tranche 2 Notes shall be issued for any part payment towards a Tranche 2 Note and after aggregation of all such amounts, any remaining fractional sums
pursuant to an Optional Warrant Conversion Notice shall be discounted when calculating the number of Tranche 2 Notes to be issued. 


  

	3.6	 No Tranche 3 Notes shall be issued to any person if the Shareholder Approval is obtained on or before
7 August, 2020. 


  

	3.7	 If the Shareholder Approval is not obtained on or before 7 August, 2020, the Company shall deliver Tranche
3 Notes (in the face amount of £1 for each Tranche 3 Note issued) to each Original Warrantholder that delivers an Alternative Warrant Conversion Notice in accordance with section 5(i)(ii) of the Securities Purchase Agreement, within five
(5) Business Days after the surrender by the holder of the certificate representing the Warrant and the delivery of the Alternative Warrant Conversion Notice. 



  
 12 














	3.8	 For so long as the Senior Loan remains outstanding, no Notes shall be issued or deemed issued to any person
pursuant to this Instrument unless such person has first executed the Subordination Agreement or a deed of adherence to the Subordination Agreement (pursuant to which such person becomes bound by the terms of the Subordination Agreement) and
provided a copy of such executed document to the Company and the Senior Lenders. 


  

	4.	 USE OF PROCEEDS 



 

	4.1	 The proceeds of all subscriptions for the Notes shall be used in accordance with the terms and conditions of
Section 5(j) of the Securities Purchase Agreement. 


  

	4.2	 No part of the proceeds of any subscription for the Notes shall be used by the Company to make any dividend or
distribution to any shareholder in the Company, or for the repurchase of Ordinary Shares. 


  

	5.	 REPAYMENT OF NOTES 



 

	5.1	 The Notes shall be repaid in accordance with Part 1 of Schedule 2. 



 

	5.2	 All Notes repaid by the Company shall be automatically and immediately cancelled and shall not be reissued.



  

	6.	 INTEREST 



Until the Notes are repaid by the Company or converted into Ordinary Shares, in each case in accordance with the provisions of this Instrument,
interest shall accrue and be paid on the principal amount of the Notes outstanding at the rate and in the manner provided in Part 1 of Schedule 2. 
  

	7.	 CERTIFICATES 



 

	7.1	 Each Noteholder (or the joint holders of any Notes) shall be entitled to receive, without charge, one Tranche 1
Note Certificate and/or Tranche 2 Note Certificate and/or Tranche 3 Note Certificate (as applicable) for the Tranche 1 Notes and/or Tranche 2 Notes and/or Tranche 3 Notes registered in his (or their) names. 



 

	7.2	 Where any Notes are held jointly, the Company shall not be bound to issue more than one Certificate in respect
of such Notes and delivery of a Certificate to the person who is first named in the Register as Noteholder shall be sufficient delivery to all joint holders of such Notes. 



  
 13 














	7.3	 Each Certificate shall: 



 

	 	(a)	 bear a denoting number; 



 

	 	(b)	 indicate whether it relates to Tranche 1 Notes, Tranche 2 Notes, or Tranche 3 Notes; 



 

	 	(c)	 be issued and executed by the Company as a deed in the form (or substantially in the form) set out in Part 1 of
Schedule 1, Part 2 of Schedule 1 or Part 3 of Schedule 1 (as applicable); and 


  

	 	(d)	 have the Conditions endorsed on or attached to it. 



 

	7.4	 In the case of repayment or transfer of part only of a Noteholder’s Notes, the Certificate(s) in respect
of such Notes shall be either: 


  

	 	(a)	 endorsed with a memorandum of the nominal amount of the Notes so redeemed or transferred and the date of such
repayment or transfer; or 


  

	 	(b)	 cancelled and (without charge) replaced by a new Certificate for the balance of the principal amount of the
Notes not then repaid or transferred. 


  

	8.	 THE REGISTER 



 

	8.1	 The Company shall keep and maintain the Register at the Registered Office or (subject always to the provisions
of section 743 of the Act) at such other place as the Company may from time to time appoint for this purpose and notify to the Noteholders. 


  

	8.2	 There shall be entered in the Register: 



 

	 	(a)	 the names and addresses of the Noteholders for the time being; 



 

	 	(b)	 the principal amount of the Notes held by each Noteholder; 



 

	 	(c)	 whether the Notes held by each Noteholder are Tranche 1 Notes, Tranche 2 Notes or Tranche 3 Notes;



  

	 	(d)	 the date of issue of each of the Notes and the date on which the name of each Noteholder is entered in the
Register in respect of the Notes registered in his name; 


  

	 	(e)	 the serial number of each Certificate issued and the date of its issue; and 



  
 14 














	 	(f)	 the date(s) of all transfers and changes of ownership of any of the Notes. 



 

	8.3	 The Company shall promptly amend the Register to record any change to the name or address of a Noteholder that
is notified in writing to the Company by that Noteholder. 


  

	8.4	 The Noteholders or any of them, or any person authorised by a Noteholder, shall be at liberty at all reasonable
times during office hours to inspect the Register and to take copies of or extracts from it or any part of it. 


  

	8.5	 Every Noteholder shall be recognised by the Company as entitled to his Notes free from any equity, set-off or
cross-claim against the original or an intermediate holder of such Notes. 


  

	9.	 NOTES NOT TO BE QUOTED



 No application has been, or shall be, made (unless pursuant to paragraph 7.2 of Part 1 of Schedule 2) to any
investment exchange (whether in the United Kingdom or otherwise) for permission to deal in, or for an official or other listing or quotation, in respect of the Notes. 
  

	10.	 SET-OFF 



Payments of principal and interest in respect of the Notes shall be paid by the Company to the Noteholders in accordance with the Conditions
without any deduction or withholding (whether in respect of any set-off, counterclaim or otherwise whatsoever) unless the deduction or withholding is required by law. 
  

	11.	 MEETINGS OF NOTEHOLDERS 



Meetings of the Noteholders shall be convened and held in accordance with the provisions of Schedule 3. 

 

	12.	 VARIATION 



 

	12.1	 All or any of the rights for the time being attached to the Notes or other provisions of this Instrument may
from time to time (whether or not the Company is being wound up) be altered or abrogated with the prior written consent of a Noteholder Majority. Any such alteration or abrogation shall be effected by way of deed poll executed by the Company and
expressed to be supplemental to this Instrument. 



  
 15 














	12.2	 Modifications to this Instrument which are of a minor nature or made to correct a manifest error may be
effected by way of deed poll executed by the Company and expressed to be supplemental to this Instrument. 


  

	12.3	 The Company shall, within 5 Business Days of making any variation pursuant to this clause 12, send to each
Noteholder (or, in the case of joint holders, to the Noteholder named first in the Register) a copy of the deed poll (or other document) effecting the variation. 



 

	12.4	 Any modification, alteration or abrogation made pursuant to clause 12.1 or clause 12.2 shall be binding on all
the Noteholders. 


  

	13.	 ENFORCEMENT AND THIRD PARTY
RIGHTS 


  

	13.1	 From and after the date of this Instrument, and for so long as any Notes are outstanding or any amount is
payable or repayable by the Company in respect of the Notes, the Company undertakes to duly perform and observe its obligations under this Instrument. 


  

	13.2	 Except as expressly provided in clause 13.3, a person who is not a party to this Instrument shall not have any
rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Instrument. 


  

	13.3	 This Instrument shall operate for the benefit of all Noteholders and each Noteholder shall be entitled to sue
for the performance or observance of the provisions of this Instrument in his own right so far as his own holding of Notes is concerned. 


  

	14.	 NOTICES 



Any notice to be given to or by any Noteholder(s) for the purposes of this Instrument shall be given in accordance with the provisions of
paragraph 9 and paragraph 10 of Part 3 of Schedule 2. 
  

	15.	 GOVERNING LAW AND JURISDICTION



  

	15.1	 This Instrument and the Notes and any dispute or claim arising out of or in connection with any of them or
their subject matter or formation (including non- contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. 



  
 16 














	15.2	 The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of
or in connection with this Instrument or the Notes or their subject matter or formation (including non-contractual disputes or claims). 



This instrument has been executed as a deed and is delivered and takes effect on the date stated at the beginning of it. 

  
 17 













 Schedule 1 

Part 1. - Form of Tranche 1 Note Certificate 
  

	
	Certificate No. [NUMBER]
	
	Date of Issue [•] [June] 2020
	
	Amount £[AMOUNT]

 MEREO BIOPHARMA GROUP PLC 

£[AMOUNT] 
 UNSECURED
CONVERTIBLE LOAN NOTES 
 Created and issued pursuant to a resolution of a duly appointed committee of the board of directors of the Company passed on
3 June 2020. 
 THIS IS TO CERTIFY THAT [NAME OF NOTEHOLDER] is the registered holder of £[AMOUNT] of the £[AMOUNT] unsecured
convertible loan notes 2023 constituted by an instrument entered into by the Company on [•] [June] 2020 (“Instrument”). These are Tranche 1 Notes. Such Tranche 1 Notes are issued with the benefit of and subject to the
provisions contained in the Instrument and the Conditions endorsed on or annexed to this Certificate. 
 Notes: 

1. The Tranche 1 Notes are repayable and shall bear interest in accordance with the Conditions. 

2. This Certificate must be surrendered to the Company before any transfer or repayment, whether of the whole or any part of the Tranche 1 Notes comprised in
it, can be registered or effected, or any new certificate issued in exchange. 
 3. Any change of address of the Noteholder(s) must be notified in writing
signed by the Noteholder(s) to the Company at the Registered Office. 
 4. Subject to the Conditions, the Tranche 1 Notes are transferable in amounts and in
integral multiples of £1. 
 5. No transfer of any part of the Tranche 1 Notes represented by this Certificate can be registered without production of
this Certificate. 
 6. Words and expressions defined in the Instrument shall bear the same meaning in this Certificate and in the Conditions. 

7. The Tranche 1 Notes and any dispute or claim arising out of or in connection with any of them or their subject matter or formation (including
non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
connection with the Tranche 1 Notes or their subject matter or formation (including non-contractual disputes or claims). 

  
 18 













 8. A copy of the Instrument is available for inspection at the registered office of the Company. 

This Certificate has been executed as a deed and is delivered and takes effect on the date of issue stated at the beginning of it. 

Executed as a deed by MEREO BIOPHARMA GROUP PLC acting by [NAME OF DIRECTOR], a director 

[SIGNATURE OF DIRECTOR] 
 Director in the presence of: 

Witness
Signature:                                       
   

Name:                         
                                     

Address:                        
                                  

Occupation 
 Dated: [INSERT DATE] 

  
 19 













 Part 2. - Form of Tranche 2 Note Certificate 

Certificate No. [NUMBER] 
 Date of Issue [•]
[•] [•] 
 Amount £[AMOUNT] 

MEREO BIOPHARMA GROUP PLC 

£[AMOUNT] 
 UNSECURED
CONVERTIBLE LOAN NOTES 
 Created and issued pursuant to a resolution of a duly appointed committee of the board of directors of the Company passed on
3 June 2020. 
 THIS IS TO CERTIFY THAT [NAME OF NOTEHOLDER] is the registered holder of £[AMOUNT] of the £[AMOUNT] unsecured convertible
loan notes with a Maturity Date of [•], constituted by an instrument entered into by the Company on [•] [June] 2020 (“Instrument”). These are Tranche 2 Notes. Such Tranche 2 Notes are issued with the benefit of and subject
to the provisions contained in the Instrument and the Conditions endorsed on or annexed to this Certificate. 
 Notes: 

1. The Tranche 2 Notes are repayable and shall bear interest in accordance with the Conditions. 

2. This Certificate must be surrendered to the Company before any transfer or repayment, whether of the whole or any part of the Tranche 2 Notes comprised in
it, can be registered or effected, or any new certificate issued in exchange. 
 3. Any change of address of the Noteholder(s) must be notified in writing
signed by the Noteholder(s) to the Company at the Registered Office. 
 4. Subject to the Conditions, the Tranche 2 Notes are transferable in amounts and in
integral multiples of £1. 
 5. No transfer of any part of the Tranche 2 Notes represented by this Certificate can be registered without production of
this Certificate. 
 6. Words and expressions defined in the Instrument shall bear the same meaning in this Certificate and in the Conditions. 

7. The Tranche 2 Notes and any dispute or claim arising out of or in connection with any of them or their subject matter or formation (including
non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
connection with the Tranche 2 Notes or their subject matter or formation (including non-contractual disputes or claims). 

  
 20 













 8. A copy of the Instrument is available for inspection at the registered office of the Company. 

This Certificate has been executed as a deed and is delivered and takes effect on the date of issue stated at the beginning of it. 

Executed as a deed by MEREO BIOPHARMA GROUP PLC acting by [NAME OF DIRECTOR], a director 

 
  

[SIGNATURE OF DIRECTOR] 
 Director in the presence of: 

Witness
Signature:                                       
      

Name:                         
                                        

Address:                        
                                     

Occupation 
 Dated: [INSERT DATE] 

  
 21 













 Part 3. - Form of Tranche 3 Note Certificate 

Certificate No. [NUMBER] 
 Date of Issue [•]
[•] [•] 
 Amount £[AMOUNT] 

MEREO BIOPHARMA GROUP PLC 

£[AMOUNT] 
 UNSECURED
LOAN NOTES 
 Created and issued pursuant to a resolution of a duly appointed committee of the board of directors of the Company passed on 3 June 2020.

 THIS IS TO CERTIFY THAT [NAME OF NOTEHOLDER] is the registered holder of £[AMOUNT] of the £[AMOUNT] unsecured loan notes with a Maturity Date
of [•] June 2025, constituted by an instrument entered into by the Company on [•] [June] 2020 (“Instrument”). These are Tranche 3 Notes. Such Tranche 3 Notes are issued with the benefit of and subject to the provisions
contained in the Instrument and the Conditions endorsed on or annexed to this Certificate. 
 Notes: 

1. The Tranche 3 Notes are repayable and shall bear interest in accordance with the Conditions. 

2. This Certificate must be surrendered to the Company before any transfer or repayment, whether of the whole or any part of the Tranche 3 Notes comprised in
it, can be registered or effected, or any new certificate issued in exchange. 
 3. Any change of address of the Noteholder(s) must be notified in writing
signed by the Noteholder(s) to the Company at the Registered Office. 
 4. Subject to the Conditions, the Tranche 3 Notes are transferable in amounts and in
integral multiples of £1. 
 5. No transfer of any part of the Tranche 3 Notes represented by this Certificate can be registered without production of
this Certificate. 
 6. Words and expressions defined in the Instrument shall bear the same meaning in this Certificate and in the Conditions. 

7. The Tranche 3 Notes and any dispute or claim arising out of or in connection with any of them or their subject matter or formation (including
non-contractual disputes or claims) shall be governed by, and construed in accordance with, the law of England and Wales. The courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
connection with the Tranche 3 Notes or their subject matter or formation (including non-contractual disputes or claims). 
 8. A copy of the Instrument is
available for inspection at the registered office of the Company. 
 This Certificate has been executed as a deed and is delivered and takes effect on the
date of issue stated at the beginning of it. 

  
 22 













 Executed as a deed by MEREO BIOPHARMA GROUP PLC 

acting by [NAME OF DIRECTOR], a director 
  

 
 [SIGNATURE OF DIRECTOR] 

Director in the presence of: 
 Witness
Signature:                                       
 

Name:                         
                                   

Address:                        
                                

Occupation 
 Dated: [INSERT DATE] 

  
 23 













 Schedule 2 The Conditions 

Part 1. Interest, repayment and redemption 
  

	1.	 INTEREST 



 

	1.1	 Interest shall initially be payable on any outstanding Tranche 1 Notes (so far as not converted under Part 2 of
Schedule 2) at a fixed rate of 10% per annum (the “Interest Rate”), subject to the following adjustments: 


  

	 	(a)	 if Shareholder Approval is obtained on or prior to 7 August 2020, the initial 10% rate shall be reduced to
6% per annum, with effect retroactively as of the Effective Date; 


  

	 	(b)	 if an Event of Default takes place and is not remedied by the Company in accordance with the applicable
provisions of this Part 1 of Schedule 2, the Tranche 1 Interest Rate shall be increased by 2% per annum with effect from the date of such Event of Default (or, if applicable, the expiry of any cure period applicable thereto) (the
“Tranche 1 Default Rate”); and 


  

	 	(c)	 if the Tranche 1 Extension Option is exercised, interest shall cease to be payable on the Tranche 1 Notes from
the date of the relevant Tranche 1 Extension Notice (other than any interest payable at the Tranche 1 Default Rate following an Event of Default, which, for the avoidance of doubt, shall apply at a flat rate of 2% in such circumstances and remain
payable). 


  

	1.2	 Interest shall not be payable on any outstanding Tranche 2 Notes or Tranche 3 Notes other than where an Event
of Default takes place and is not remedied by the Company in accordance with the applicable provisions of this Part 1 of Schedule 2, where interest shall be payable on the Tranche 2 Notes and/or Tranche 3 Notes (as applicable) at a rate of
2% per annum with effect from the date of such Event of Default (or, if applicable, the expiry of any cure period applicable thereto) (the “Tranche 2 Default Rate” and “Tranche 3 Default Rate”, respectively).



  

	1.3	 Any interest due under paragraphs 1.1 or 1.2 shall be payable on the Redemption Date. 



  
 24 














	1.4	 Interest, if payable, shall accrue daily at the Interest Rate and shall be calculated on the basis of a 365-day
year and the actual number of days elapsed from the date of issue of the relevant Notes to the Redemption Date. 


  

	1.5	 If the Company fails to pay redemption monies when due, interest shall accrue on the unpaid amount at the
applicable Default Rate. 


  

	2.	 REPAYMENT OF PRINCIPAL 



 

	2.1	 As and when the Notes (or any part of them) are to be redeemed in accordance with paragraph 4 of this Part 1 of
Schedule 2, the Company shall pay the Noteholders the principal amount of the Notes which are to be redeemed, subject to adjustment in accordance with paragraph 4.2 of this Part 2 of Schedule 2. 



 

	2.2	 No prepayment of the principal amount of the Notes or any interest accrued thereon prior to the earlier of the
Maturity Date or, in the event of a Change of Control, the date on which the consideration in respect of such Change of Control is remitted to the holders of Ordinary Shares, shall be permitted without the consent of a Noteholder Majority, and, if
required, the consent of the Senior Lenders pursuant to the terms of the Subordination Deed. 


  

	2.3	 At any time prior to the Tranche 1 Maturity Date, a Qualifying Noteholder may (but shall not be required to)
notify the Company that it wishes to extend the Tranche 1 Maturity Date in respect of that Noteholder’s Tranche 1 Notes to a new date to be specified in such notice provided such date is a Business Day and not later than the date 10 years after
the date of this Instrument (a “Tranche 1 Extension Notice”), and the Company shall accept such extension (the “Tranche 1 Extension Option”), whereupon the Tranche 1 Maturity Date shall be revised accordingly. A
Qualifying Noteholder may only issue a Tranche 1 Extension Notice once and any such Tranche 1 Extension Option must be used in respect of all Tranche 1 Notes held by such Qualifying Noteholder. From the date of such Tranche 1 Extension Notice, other
than amounts accrued prior to delivery of the Tranche 1 Extension Notice, no additional interest shall be payable on the Tranche 1 Notes held by the exercising Qualifying Noteholder (other than any interest which becomes payable at the Tranche 1
Default Rate). 


  

	2.4	 On the date of the Tranche 1 Extension Notice the exercising Qualifying Noteholder shall deliver to the Company
the Tranche 1 Note Certificate in respect of the Tranche 1 Notes which are the subject of such Tranche 1 Extension Notice, and the Company shall, within 5 Business Days’ of the exercise of the Tranche 1 Extension Option, issue to such
Qualifying Noteholder a replacement Tranche 1 Note Certificate bearing the revised Tranche 1 Maturity Date. 



  
 25 














	2.5	 A Qualifying Noteholder who holds both Tranche 1 Notes and Tranche 2 Notes may (but shall not be required) if
they have already served an Extension Notice (or contemporaneously with the service of an Extension Notice), notify the Company that it wishes to extend the Tranche 2 Maturity Date in respect of that Noteholder’s Tranche 2 Notes to the same
date that it has specified as the Tranche 1 Maturity Date pursuant to its Extension Notice for Tranche 1 Notes (such further notice being a “Tranche 2 Extension Notice”), and the Company shall accept such extension (the
“Tranche 2 Extension Option”), whereupon the Tranche 2 Maturity Date shall be revised accordingly. A Qualifying Noteholder may only issue a Tranche 2 Extension Notice once and any such Tranche 2 Extension Option must be used in
respect of all Tranche 2 Notes held by such Qualifying Noteholder. 


  

	2.6	 On the date of the Tranche 2 Extension Notice the exercising Qualifying Noteholder shall deliver to the Company
the Tranche 2 Note Certificate in respect of the Tranche 2 Notes which are the subject of such Tranche 2 Extension Notice, and the Company shall, within 5 Business Days’ of the exercise of the Tranche 2 Extension Option, issue to such
Qualifying Noteholder a replacement Tranche 2 Note Certificate bearing the revised Tranche 2 Maturity Date. 


  

	2.7	 Any Qualifying Noteholder who holds Tranche 3 Notes may (but shall not be required), notify the Company that it
wishes to extend the Tranche 3 Maturity Date in respect of that Qualifying Noteholder’s Tranche 3 Notes to a new date to be specified in such notice provided such date is a Business Day and not later than the date 10 years after the date of
this Instrument (such notice being a “Tranche 3 Extension Notice”). Upon receipt of a Tranche 3 Extension Notice, the Company may reject a Tranche 3 Extension Notice by providing written notice of such rejection to the Noteholder
within 30 Business Days of receipt of such Tranche 3 Extension Notice (whereupon no extension of such Noteholder’s Tranche 3 Notes shall occur). If the Company does not reject a Tranche 3 Extension Notice within such foregoing period, the
Tranche 3 Extension Notice shall be considered accepted (the “Tranche 3 Extension Option”), whereupon the Tranche 3 Maturity Date shall be revised accordingly. A Qualifying Noteholder may only issue a Tranche 3 Extension Notice once
and any such Tranche 3 Extension Option must be used in respect of all Tranche 3 Notes held by such Qualifying Noteholder. 



  
 26 














	2.8	 On the date of the Tranche 3 Extension Notice the exercising Qualifying Noteholder shall deliver to the Company
the Tranche 3 Note Certificate in respect of the Tranche 3 Notes which are the subject of such Tranche 3 Extension Notice. If the Company rejects the Tranche 3 Extension Notice, the Company shall promptly return such Tranche 3 Note Certificate to
the Noteholder. If the Tranche 3 Extension Option is accepted, the Company shall, within 5 Business Days’ of the exercise of the Tranche 3 Extension Option, issue to such Qualifying Noteholder a replacement Tranche 3 Note Certificate bearing
the revised Tranche 3 Maturity Date. 


  

	3.	 TIME OF PAYMENT 



Whenever any payment of principal (or otherwise) becomes due on a day which is not a Business Day, payment shall be made on the next following
Business Day. 
  

	4.	 REDEMPTION 



 

	4.1	 The Notes then in issue (so far as not converted under Part 2 of this Schedule 2) shall be redeemed at the
principal amount together with interest on the Notes outstanding at the applicable Interest Rate on the earlier of the following dates: 


  

	 	(a)	 the Tranche 1 Maturity Date, Tranche 2 Maturity date or Tranche 3 Maturity date (as applicable); or



  

	 	(b)	 in the event of a Change of Control, the date on which the consideration in respect of such Change of Control
is remitted to the holders of Ordinary Shares; or 


  

	 	(c)	 following the occurrence of an Event of Default and the expiry of any applicable grace period applicable to
such Event of Default as set out in paragraph 5 of this Part 1 of Schedule 2 (the date on which an Event of Default occurs or, if later, the relevant grace period (if any) expires, the “Acceleration Date”), the date specified in the
relevant Redemption Notice; 


 (the “Redemption Date”). 

 

	4.2	 Subject to paragraph 4.12 below, in the event that Shareholder Approval has not been obtained on or before
7 August 2020, in addition to the amounts otherwise payable on the Redemption Date, each Noteholder holding any Tranche 1 Notes shall be entitled to be paid an additional sum on the Redemption Date, the amount of which shall be equal to the
principal amount of the Tranche 1 Notes outstanding on 7 August, 2020 and held by such Noteholder in recognition of such Noteholder not being able to (i) participate in the equity of the Company through conversion of the Tranche 1 Notes,
or (ii) benefit from any Warrants that were intended to be issued to such Tranche 1 Noteholder as part of the Transaction (such sum being the “Uplift Payment”). 



  
 27 













 Notwithstanding the foregoing, in the event that Shareholder Approval has not been obtained
on or before 7 August 2020, upon conversion of the Notes in accordance with Part 2 of Schedule 2, the Noteholder shall be entitled to the benefit of the Uplift Payment. In the event that the Shareholder Approval has not been obtained on or
before 7 August 2020 and a Noteholder did not attend (either in person or by proxy) any general meeting of the Company’s members called for the purposes of obtaining the Shareholder Approval and vote in favour of such Shareholder Approval
with the entirety of all voting rights available to such Noteholder, such Noteholder shall cease to be entitled to the benefit of the Uplift Payment in any circumstances. 
  

	4.3	 At any time after 7 August 2020, when (i) at least one Tranche 1 Noteholder is entitled to the Uplift
Payment pursuant to paragraph 4.2 above; (ii) the Closing Price is above the Tranche 1 Conversion Price; and (iii) the Company has authority from its shareholders to allot additional Ordinary Shares, the Company may at its discretion
notify all (but not some) Tranche 1 Noteholders that it wishes to satisfy its obligations in respect of all or any portion of the Uplift Payment by the issuance of further Ordinary Shares pro rata to all Noteholder(s) (such Ordinary Shares being
“Uplift Securities”) (such notice an “Uplift Allocation Notice”). 


  

	4.4	 The amount of the Uplift Payment to be satisfied by the Uplift Securities shall be calculated by: multiplying
(x) being the number of Uplift Securities the Company wishes to issue, by (y) being the Tranche 1 Conversion Price (the “Uplift Reduction Amount”). 



 

	4.5	 The Uplift Allocation Notice served pursuant to paragraph 4.3 above shall specify, at a minimum:



  

	 	(a)	 the number of Uplift Securities the Company proposes to issue; 



 

	 	(b)	 each Tranche 1 Noteholder’s current percentage holding of the aggregate voting rights in the Company; and



  

	 	(c)	 the issue date of the Uplift Securities (which shall in all cases be within 5 Business Days of the date the
Uplift Allocation Notice was served). 


  

	4.6	 In the event that: 


  

	 	(a)	 there is only one Tranche 1 Noteholder, that Noteholder shall be automatically deemed to have subscribed for
the maximum number of Uplift Securities as it is possible to subscribe without the Ownership Limit of that Tranche 1 Noteholder being exceeded; and 



  
 28 














	 	(b)	 if there is more than one Tranche 1 Noteholder, each Tranche 1 Noteholder shall be automatically deemed to have
subscribed (and such subscription shall be deemed satisfied out of each Tranche 1 Noteholder’s entitlement to the Uplift Payment) for such number of Uplift Securities as is determined pro rata to each Tranche 1 Noteholder’s proportionate
entitlement to the Uplift Payment (provided that such amount does not result in the Ownership Limit being exceeded, and if it was to so result, such Tranche 1 Noteholder shall be required to subscribe for the maximum amount of Uplift Securities that
such Tranche 1 Noteholder could receive without being in breach of the Ownership Limit, any excess Uplift Securities would then be allocated to each other Tranche 1 Noteholder (who would be deemed to subscribe for the same) pro rata to their
entitlement to the Uplift Payment until either all Uplift Securities have been allocated amongst all Tranche 1 Noteholders or all Tranche 1 Noteholders have each reached the Ownership Limit), 



and in each case the Company shall issue such Uplift Securities (which shall be credited as fully paid and rank pari passu with Ordinary Shares
of the same class in issue on the Conversion Date) within 5 Business Days of the Uplift Allocation Notice and the applicable Tranche 1 Noteholder’s entitlement to the Uplift Payment shall thereon be reduced by their proportion of the Uplift
Reduction Amount. 
  

	4.7	 At any time when (i) the Company has satisfied the entirety of its obligations in respect of the Uplift
Payment through the issue of Uplift Securities pursuant to paragraphs 4.3 to 4.6 above (or the Uplift Payment has otherwise been discharged or waived); (ii) the Closing Price is above the Tranche 1 Conversion Price, and (iii) the Company
has authority from its shareholders to allot additional Ordinary Shares; the Company may notify all (but not some) of the Tranche 1 Noteholders that it wishes to satisfy its obligations in respect of an amount of interest and/or principal under the
Tranche 1 Notes by the issuance of further Ordinary Shares pro rata to all Tranche 1 Noteholders (such Ordinary Shares being “Pay Down Securities”) (such notice a “Pay Down Notice” and such process a “Pay
Down Issue”). 


  

	4.8	 The amount of principal and interest in respect of the Tranche 1 Notes to be satisfied by the issue of Pay Down
Securities shall be calculated by: multiplying (x) being the number of Pay Down Securities the Company wishes to issue, by (y) being the Tranche 1 Conversion Price (the “Pay Down Reduction Amount”). 



 

	4.9	 The Pay Down Notice served on each Tranche 1 Noteholder pursuant to paragraph 



 

	4.7	 above shall specify, at a minimum: 



 

	 	(a)	 the number of Pay Down Securities the Company proposes to issue; 



  
 29 














	 	(b)	 each Tranche 1 Noteholder’s current percentage holding of the aggregate voting rights in the Company; and



  

	 	(c)	 the issue date of the Pay Down Securities (which shall in all cases be within 5 Business Days of the date the
Pay Down Notice was served). 


  

	4.10	 In the event that: 


  

	 	(a)	 there is only one Tranche 1 Noteholder, that Tranche 1 Noteholder shall be automatically deemed to have
subscribed for the maximum number of Pay Down Securities as it is possible to subscribe without the Ownership Limit of that Tranche 1 Noteholder being exceeded; and 



 

	 	(b)	 there is more than one Tranche 1 Noteholder, each Tranche 1 Noteholder shall be automatically deemed to have
subscribed (and such subscription shall be deemed satisfied out of each Tranche 1 Noteholder’s entitlement to principal and/or interest under the Notes) for the maximum amount of Pay Down Securities that such Tranche 1 Noteholder could receive
without being in breach of the Ownership Limit, any excess Pay Down Securities would then be allocated to each other Tranche 1 Noteholder (who would be deemed to subscribe for the same) pro rata to their entitlement outstanding interest and/or
principal under the Tranche 1 Notes until either all Pay Down Securities have been allocated amongst all Tranche 1 Noteholders or all Tranche 1 Noteholders have each reached the Ownership Limit, 



and in each case the Company shall issue such Pay Down Securities (which shall be credited as fully paid and rank pari passu with Ordinary
Shares of the same class in issue on the Conversion Date) within 5 Business Days of the Pay Down Notice and the applicable Tranche 1 Noteholder’s entitlement to principal amount and/or interest shall thereon be reduced by their proportion of
the Pay Down Reduction Amount. 
  

	4.11	 At any time when (i) the Company has satisfied all principal and interest outstanding in respect of the
Tranche 1 Notes by the issue of Pay Down Securities; (ii) the Closing Price is above the Tranche 2 Conversion Price, and (iii) the Company has authority from its shareholders to allot additional Ordinary Shares, the Company may serve a Pay
Down Notice on the Tranche 2 Noteholders, notifying them it wishes to satisfy its obligations in respect of any interest and/or principal amount under the Tranche 2 Notes by way of a Pay Down Issue, and the provisions of the foregoing paragraphs 4.7
to 4.10 above shall apply mutatis mutandis in respect of any such Pay Down Issue in respect of the Tranche 2 Notes (and in such circumstances, for the avoidance of doubt, (y) for the purposes of calculating the Pay Down Reduction Amount
pursuant to paragraph 4.8 shall be the Tranche 2 Conversion price). At any 



  
 30 














	 	
time when (i) the Company has satisfied all principal and interest outstanding in respect of the Tranche 2 Notes by the issue of Pay Down Securities; and (ii) the Company has authority
from its shareholders to allot additional Ordinary Shares, the Company may serve a Pay Down Notice on the Tranche 3 Noteholders, notifying them it wishes to satisfy its obligations in respect of any interest and/or principal amount under the Tranche
3 Notes by way of a Pay Down Issue, and the provisions of the foregoing paragraphs 4.7 to 4.10 above shall apply mutatis mutandis in respect of any such Pay Down Issue in respect of the Tranche 3 Notes (and in such circumstances, for the avoidance
of doubt, (y) for the purposes of calculating the Pay Down Reduction Amount in respect of Tranche 3 Notes pursuant to paragraph 4.8 shall be the weighted average of the Closing Price on the 5 Business Days immediately prior to the date on which
the Pay Down Notice is served in respect of such Tranche 3 Notes). 

  

	4.12	 In the event that (i) a Change of Control occurs on or prior to 7 August 2020 and Shareholder
Approval has not been obtained on or prior to the date of such Change of Control; or (ii) Shareholder Approval has not been obtained on or before 7 August 2020 and following 7 August 2020 but prior to the Tranche 1 Maturity Date, the
Company undergoes a Change of Control; in either case the Company shall pay or cause to be paid, within 3 Business Days of the date on which consideration in respect of such Change of Control is remitted to the holders of Ordinary Shares, to each
Noteholder, in addition to the sum payable pursuant to paragraph 4.1(b) of this Part 1 of Schedule 2, an additional sum, the amount of which shall be equal to the value of (a) minus ((b), (c) and (d)), where: 



 

	 	(a)	 is the pro rata amount of consideration which would have been received by such Noteholder in consideration for
their Ordinary Shares and Warrants (plus, to the extent they exist, any Tranche 3 Notes held by such Noteholder but without double-counting in respect of the value of any Warrants that were converted into such Tranche 3 Notes by the Noteholder) on
the Change of Control if that Shareholder Approval had been obtained on or prior to 7 August 2020 and as a result (i) all the Warrants held by such Noteholder as of the date of the Change of Control had become fully exercisable on or prior
to 7 August 2020; and (ii) all Tranche 1 Notes held by such Noteholder as of the date of the Change of Control had automatically converted into Ordinary Shares upon receipt of the Shareholder Approval; and 



 

	 	(b)	 is the aggregate of the principal amount of such Noteholder’s Tranche 1 Notes, together with any accrued
but unpaid interest thereon held by such Noteholder immediately prior to the Notes being redeemed pursuant to paragraph 4.1(b) of this Part 1 of Schedule 2; and 



  
 31 














	 	(c)	 is the pro rata amount of consideration actually received or due to be received by such Noteholder pursuant to
Section 2.10 of the Warrant Instrument in respect of Warrants held by such Noteholder as of the date of such Change of Control; and 


  

	 	(d)	 is the pro rata amount of consideration actually received or due to be received by such Noteholder (whether on
or prior to any Change of Control) in respect of any Ordinary Shares received by such Noteholder in exchange for Tranche 1 Notes pursuant to paragraphs 4.7 through 4.11 of this Schedule 2; 



(such sum being the “Change of Control Payment”). For the avoidance of doubt, if any Noteholder becomes entitled to be paid
the Change of Control Payment, such Noteholder shall cease to be entitled to the Uplift Payment pursuant to paragraph 4.2. 
  

	4.13	 Subject to paragraph 6 if the Noteholder Majority wishes to redeem the Notes following an Acceleration Date,
the Noteholder Majority shall give the Company written notice of the intention to exercise the right to redeem in accordance with the provisions of paragraph 4.1(b), together with confirmation on the date for such redemption (provided that such date
may not occur earlier than the date falling 20 Business Days after the relevant Acceleration Date), conditional always on any such Event of Default not being remedied in the case of paragraph 4.1(c) (“Redemption Notice”).



  

	4.14	 A Redemption Notice shall (unless the Company agrees otherwise) be irrevocable. 



 

	4.15	 For as long as the Subordination Agreement is in force, notwithstanding any of the provisions of paragraph 5 of
this Part 1 of Schedule 2, the Notes cannot be redeemed or repaid following an Acceleration Date until the applicable restriction in the Subordination Agreement has expired or been waived by the Senior Lenders; provided that such delay in payment
shall constitute an additional Event of Default hereunder. 


  

	4.16	 On the Redemption Date, the Company shall repay to all Noteholders the principal amount of the Notes so
redeemed, together with interest on such Notes outstanding at the applicable Interest Rate, and, if applicable, the Uplift Payment payable pursuant to paragraph 4.2. 



 

	4.17	 If, on redemption of a Note, a Noteholder fails to deliver the Certificate for it, or an indemnity in
accordance with these Conditions or to accept payment of moneys due to him, the Company shall pay the moneys due to him into bank account which payment shall discharge the Company from all further obligations in respect of the Note.




  
 32 














	4.18	 The Company shall cancel any Notes repaid, redeemed or purchased and shall not reissue them.



  

	5.	 EVENTS OF DEFAULT 



Subject to paragraphs 4.15 and 6.3 of this part 1 of Schedule 2, the Notes then in issue shall become immediately redeemable at the principal
amount, together with interest on the Notes outstanding, and interest shall become payable at the applicable Default Rate, if: 
  

	 	(a)	 the Company fails to pay any interest or principal in respect of the Notes on the relevant due date;



  

	 	(b)	 the Company fails to comply in any material respect with the covenants of the Notes or any of the Conditions
and does not remedy such failure within 30 calendar days; 


  

	 	(c)	 any judgment, arbitration award, order or decree for the payment of money and that is no longer subject to an
appeal process in an amount, individually or in the aggregate of at least £1,000,000 (or its equivalent in other currencies) is rendered against any Group Company and not cured or withdrawn within 30 calendar days of such judgment, award,
order or decree; 


  

	 	(d)	 a Group Company incurs an Event of Default (as such term is defined in the Novartis Loan Note) pursuant to the
terms of the Novartis Loan Note and such Event of Default is not remedied within the greater of (i) any applicable grace period pursuant to the terms of the Novartis Loan Note; and (ii) 30 days from the occurrence of such Event of Default;
and results in the acceleration by Novartis of any indebtedness owed pursuant to the terms of the Novartis Loan Note; 


  

	 	(e)	 a Group Company incurs an event of default (howsoever defined) in respect of any indebtedness in a principal
amount in excess of £1,000,000 and fails to cure (or have waived) such event of default within 30 calendar days of such event of default; 


  

	 	(f)	 a Group Company commits a material breach of any material contract to which such Group Company is a party and
fails to cure (or have waived) such material breach within 30 calendar days of such event of default 



  
 33 














	 	(g)	 an encumbrancor takes possession or a receiver is appointed of the whole or the major part of the assets or
undertaking of a Group Company or if distress, execution or other legal process is levied or enforced or sued out on or against the whole or the major part of the assets of any Group Company and is not discharged, paid out, withdrawn or removed
within 30 calendar days; 


  

	 	(h)	 a Group Company is the subject of any proceeding in bankruptcy or for their dissolution, liquidation,
winding-up, composition or other relief under any applicable insolvency or bankruptcy laws, whether voluntary or involuntary and, if involuntary, is not dismissed within 60 calendar days of filing; 



 

	 	(i)	 an administration order is made in relation to any Group Company; or 



 

	 	(j)	 an order is made, or an effective resolution is passed, for the winding-up, liquidation, administration or
dissolution of any Group Company (except for the purpose of reorganisation or amalgamation of the Group Companies). 


  

	6.	 ACTION FOLLOWING EVENT OF DEFAULT



  

	6.1	 The Company shall give written notice to the Noteholders as soon as reasonably practicable following the
Company becoming aware of the occurrence of an event specified in paragraph 5, giving reasonable details of that event. 


  

	6.2	 Following receipt of the notice provided pursuant to paragraph 6.1 above, and, if applicable, the expiry of any
cure period provided for such Event of Default, the Noteholders shall have a period of 10 Business Days in which they may exercise their right to waive such Event of Default by Noteholder Majority Consent. 



 

	6.3	 If the Noteholder Majority waives any Event of Default then the Notes shall cease to be immediately redeemable,
and no further interest shall accrue at the applicable Default Rate in respect of such Event of Default (for the avoidance of doubt, notwithstanding such waiver, the Noteholders’ shall remain entitled to any interest accrued at the applicable
Default Rate between the date of the Event of Default and the date of waiver by the Noteholder Majority). 


  

	7.	 TAXATION 



 

	7.1	 All payments to be made by the Company to a Noteholder under the Note shall be made free and clear of and
without any deduction or withholding for or on account of tax (a “Tax Deduction”), unless a Tax Deduction is required by law. If a Tax Deduction is required by law, the amount of the payment due from the Company shall be increased
to an amount which (after making any Tax Deduction) leaves an amount equal to the payment which would have been due if no Tax Deduction had been required. 



  
 34 














	7.2	 Each Noteholder shall, in consultation with the Company, take all reasonable steps to mitigate any
circumstances which arise and which would result in any amount becoming payable under or pursuant to paragraph 7.1 above, including (but not limited to) transferring its rights and obligations under this Instrument and the Notes to another affiliate
of such Noteholder and permitting the listing of the Notes on a recognised stock exchange. 


  

	7.3	 Paragraph 7.2 above does not in any way limit the obligations of the Company under this Instrument.



  

	7.4	 Each Noteholder and the Company shall co-operate in completing any procedural formalities necessary for the
Company to obtain authorisation to make that payment without a Tax Deduction including using commercially reasonable endeavours to procure that investors in such Noteholder complete such procedural formalities. 



 

	7.5	 If the Company makes an increased payment under paragraph 7.1 (a “Tax Payment”) and the
relevant Noteholder shall (and shall use commercially reasonable endeavours to procure that investors will) co-operate with the Company to take any reasonable steps to: 



 

	 	(a)	 investigate the availability of any credit against, relief or remission for, or repayment of any Tax is
attributable to that increased payment of which that Tax Payment forms part, to that Tax Payment or to a Tax Deduction in consequence of which that Tax Payment was required (“Tax Credit”); and 



 

	 	(b)	 obtain and/or utilise that Tax Credit, 



and the Noteholder shall (and shall use commercially reasonable endeavours to procure that investors will) pay an amount to the Company which
that Noteholder (or investors as applicable) determines (acting reasonably) will leave it (after that payment) in the same after-Tax position as it would have been in had some or all of the Tax Payment not been required to be made by the Company.


  
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 Part 2. Conversion 

 

	1.	 CONVERSION 



 

	1.1	 Without prejudice to the provisions paragraphs 4.3 to 4.11 of Schedule 2 Part 1, the Notes shall not be capable
of conversion prior to Shareholder Approval having been obtained and no Noteholder shall serve any Conversion Notice prior to such time. 


  

	1.2	 Subject to paragraph 1.1 and paragraph 1.4 of this Part 2 of Schedule 2, all outstanding Tranche 1 Notes shall
automatically convert into a number of fully paid Ordinary Shares upon Shareholder Approval being obtained, determined by dividing (x) the sum of (i) the outstanding principal amount, plus (ii) all accrued and unpaid interest thereon, plus
(iii) any amount of the Uplift Payment (to the extent the same is applicable pursuant to the terms of this Instrument) which has become due and payable in accordance with paragraph 4.2 and has not already been paid or satisfied by the issue of
Uplift Securities (or otherwise), by (y) the Tranche 1 Conversion Price then in effect; provided that (but subject to paragraph 1.4 of this Part 2 of Schedule 2 below) following such conversion, no individual Noteholder shall hold more
than 9.99% of the aggregate voting rights in the Company (on a fully diluted basis) (the “Ownership Limit”). In the event that Conversion of any Noteholder’s holding of Notes would result in such Noteholder exceeding the
Ownership Limit, the principal amount of the Notes held by such Noteholder which shall convert shall be the greatest amount possible without that Noteholder exceeding such Ownership Limit and the remaining principal balance on such Notes shall
remain outstanding. 


  

	1.3	 Subject to paragraphs 1.1, 1.2 and 1.4 of this Part 2 of Schedule 2: 



 

	 	(a)	 each Noteholder holding Tranche 1 Notes shall have the right, at any time prior to the Tranche 1 Maturity Date,
to serve a Conversion Notice on the Company to convert all or, if the Ownership Limit applies, part of such Noteholder’s Tranche 1 Notes then outstanding (together with any accrued but unpaid interest thereon) into fully paid Ordinary Shares at
the Tranche 1 Conversion Price per Share; and 


  

	 	(b)	 each Noteholder holding Tranche 2 Notes shall have the right, at any time prior to the Tranche 2 Maturity Date
applicable to such Noteholder’s Tranche 2 Notes, to serve a Conversion Notice on the Company to convert all or, if the Ownership Limit applies, part of such Noteholder’s Tranche 2 Notes then outstanding (together with any accrued but
unpaid interest thereon) into fully paid Ordinary Shares at the Tranche 2 Conversion Price per Share, 



  
 36 














	 	
provided that, in each of the foregoing cases, at the time of the Conversion Notice, either (i) such Noteholder’s aggregate voting rights in the Company is not in excess of the
Ownership Limit and would not become in excess of the Ownership Limit as a result of the conversion contemplated by such Conversion Notice; or (ii) such Noteholder has waived the application of the Ownership Limit in accordance with paragraph
1.4 of this Part 2 of Schedule 2. 

  

	1.4	 Notwithstanding the foregoing, a Noteholder may increase or decrease the Ownership Limit to any other
percentage, by written notice to the Company; provided, that the Noteholder may not decrease the limitation prior to August 8, 2020; provided further that a waiver by the Noteholder of the Ownership Limit or a request to increase the Ownership
Limit requires not less than 61 days prior written notice to the Company (with such waiver of the Ownership Limit or request to increase the Ownership Limit taking effect only upon the expiration of such 61 day notice period and applying only to the
Noteholder and not to any other holder of Notes) and that such Ownership Limit shall never be increased above 19.99%. 


  

	1.5	 The Conversion Notice shall set out, at a minimum: 



 

	 	(a)	 the principal amount of the Tranche 1 Notes and/or Tranche 2 Notes to be converted; 



 

	 	(b)	 the amount (if any) of accrued but unpaid interest on such principal amount which is to be converted;



  

	 	(c)	 the Noteholder’s current percentage holding of the aggregate voting rights in the Company;



  

	 	(d)	 the Conversion Date; 



 

	 	(e)	 whether the Ordinary Shares resulting from conversion are to be delivered as ADSs; and 



 

	 	(f)	 any conditions (if any) applicable to the conversion and agreed in writing in advance by the Company.



  

	1.6	 If and to the extent that the Ordinary Shares issued are to be delivered as ADSs, the Noteholder shall be
required to deliver to the Company a completed Issuance and Delivery Instruction in the form set out in Part 4 of this Schedule 2 (as such form may be amended from time to time by notice to the Noteholder) duly completed and executed by the
Noteholder no later than 3 Business Days following service of the relevant Conversion Notice on the Company. 



  
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	1.7	 In the event of any failure by a Noteholder to deliver a duly completed Issuance and Delivery Instruction
within such time period the Company shall disregard such Noteholder’s request for delivery of the relevant Ordinary Shares as ADSs and shall issue the number of Ordinary Shares specified in the Conversion Notice to the Noteholder on the
Conversion Date in accordance with paragraph 2 of this Part 2 of Schedule 2. 


  

	1.8	 The Service of a Conversion Notice shall be irrevocable and binding on the Noteholder. 



 

	2.	 PROCEDURES ON CONVERSION 



 

	2.1	 Subject to paragraph 1.1 of this Part 2 of Schedule 2, on the Conversion Date, the Directors shall convert the
principal amount of the Notes and accrued but unpaid interest and any amount of the Uplift Payment (to the extent the same is applicable pursuant to the terms of this Instrument) which has become due and payable in accordance with paragraph 4.2 and
has not already been paid or satisfied by the issue of Uplift Securities (or otherwise), into such number of new fully paid Ordinary Shares at the applicable Tranche 1 Conversion Price or Tranche 2 Conversion Price (as the case may be) as set out in
paragraph 1 of this Part 2 of Schedule 2 in accordance with the following provisions of paragraph 2.2 to paragraph 2.5 (inclusive). 


  

	2.2	 Conversion of the Notes shall be effected by the Company redeeming the relevant Notes on the Conversion Date.
Each Noteholder whose Notes are being converted shall be deemed to irrevocably authorise and instruct the Company to apply the redemption moneys payable to that Noteholder in subscribing for Ordinary Shares on conversion of the Notes.



  

	2.3	 In the event that a Noteholder has stated in the relevant Conversion Notice that the Ordinary Shares arising
from conversion are to be delivered as ADSs, and there is an effective registration statement covering the Ordinary Shares to be issued on such conversion, then such Ordinary Shares may be issued to, and deposited with (and otherwise registered in
the name of) the custodian (or its nominee) of the Depositary, and following such issuance and deposit the Company will direct the Depositary to issue an amount of ADSs via DTC (with such ADSs being eligible for listing on Nasdaq) in accordance with
the corresponding Issuance and Delivery Instruction. 



  
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	2.4	 Ordinary Shares arising on conversion of the Notes (and any applicable accrued but unpaid interest) shall be
issued and allotted by the Company to the Noteholder or (where a Noteholder has delivered an Issuance and Delivery Instruction) to the custodian of the Depositary on the Conversion Date and the certificates (if physical certificates are requested by
such Noteholder) for such Ordinary Shares shall be despatched to the persons entitled to them at their own risk. 


  

	2.5	 The Ordinary Shares arising on conversion of the Notes shall be credited as fully paid and rank pari passu with
Ordinary Shares of the same class in issue on the Conversion Date and shall carry the right to receive all dividends and other distributions declared, made or paid after the Conversion Date. 



 

	2.6	 The entitlement of each Noteholder to a fraction of a Share shall be rounded down to the nearest whole number
of Ordinary Shares which result from the conversion of the Notes. 


  

	2.7	 In the event that a Noteholder requires Ordinary Shares arising on conversion to be delivered as ADSs, the
entitlement of such Noteholder to ADSs shall be calculated using the ADS Exchange Ratio. No fractional ADSs will be issued, and any fractional entitlements to an ADS shall be issued to the relevant Noteholder in the form of Ordinary Shares in
accordance with Part 2 of this Schedule 2, rounded down to the nearest whole share. 


  

	2.8	 In the event that the Ordinary Shares in issue on the Conversion Date are traded on the AIM Market operated by
London Stock Exchange plc, the Company shall use its reasonable best endeavours to ensure that the Ordinary Shares to be issued upon the conversion of the relevant Notes are admitted to trading on the AIM Market as soon as reasonably practicable
following the Conversion Date. In addition, as soon as practicable following the general meeting at which the Company seeks to obtain Shareholder Approval, the Company shall make or cause to be made an application to AIM for a block listing (up to
the maximum amount available to the Company under AIM block listing rules and in consideration of block listings registered at the time of this Agreement) or otherwise to admit upon Admission or as soon as permitted by AIM thereafter the maximum
number of Ordinary Shares that may be acquired upon conversion of the Notes. Further, the Company shall list the Ordinary Shares issuable upon conversion of the Notes on each other securities exchange on which the Ordinary Shares are then listed
and/or admitted to trading. 



  
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 Part 3. Transfer provisions, Undertakings and other matters 

 

	1.	 The Company shall recognise the registered holder of any Notes as the absolute owner of them and shall not
(except as provided by statute or as ordered by a court of competent jurisdiction) be bound to take notice or see to the execution of any trust (whether express, implied or constructive) to which any Note may be subject. The Company shall not
(except as provided by statute or as ordered by a court of competent jurisdiction) be bound to enter any notice of any trust (whether express, implied or constructive) on the register in respect of any of the Notes. The Notes are freely transferable
in accordance with this Part 3 of Schedule 2 in integral multiples of £1 by instrument in writing in the usual common form (or in such other form as the Directors may approve) and such instrument need not be under seal. Additionally and,
notwithstanding any other provision of this Instrument, for so long as the Subordination Agreement remains in force and effect, no transfer of the Notes may take place unless the transferee in respect of those Notes being transferred is either a
party to the Subordination Agreement or has entered into a deed of adherence to be bound by the terms of such Subordination Agreement, or has otherwise entered into subordination arrangements with the Senior Lenders in writing or the requirement to
enter into subordination arrangements with the Senior Lenders has been otherwise waived by the Senior Lenders in writing in advance of such intended transfer of the Notes; any attempt to transfer Notes in breach of the foregoing provisions is
void ab initio. 


  

	2.	 Each instrument of transfer shall be signed by the transferor, and the transferor shall be deemed to remain the
owner of the Notes to be transferred until the name of the transferee is entered in the register in respect of such Notes. 


  

	3.	 Each instrument of transfer shall be sent to, or left for registration at, the registered office of the Company
for the time being, and shall be accompanied by the Certificate(s) for the Notes to be transferred and any other evidence that the Company may require to prove the title of the transferor or his right to transfer the Notes (and, if such instrument
is executed by some other person on his behalf, the authority of that person to do so). All instruments of transfer that are registered may be retained by the Company. 



 

	4.	 No transfer of Notes shall be registered in respect of which a Redemption Notice, an Uplift Allocation Notice,
a Pay Down Notice or Conversion Notice has been given. 



  
 40 














	5.	 The Company undertakes that, while an aggregate principal amount of Notes greater than £10,000,000
remains in issue, it shall not, without prior Noteholder Majority Consent: 


  

	 	(a)	 sell, transfer, lease, licence or otherwise dispose of any material asset or business of any Group Company
(including the sale, transfer or other disposition of a Group Company’s rights to a third party), other than in the ordinary course of business; 


  

	 	(b)	 carry out any merger, reorganisation, restructuring or sale of all or substantially all of the assets and/or
business of any Group Company; 


  

	 	(c)	 effect the liquidation, dissolution, or winding of any Group Company, or the cessation of all or substantially
all of the business of any Group Company; 


  

	 	(d)	 authorise any debt security (the incurrence, or extension of any credit or loan guarantee in respect of any
loan or grant of credit exceeding £800,640.512(save that, for the avoidance of doubt, no Noteholder Majority Consent shall be required for (i) any refinancing, in whole or in part, of any Existing Indebtedness; or (ii) the
subscription by any Qualifying Noteholder (and the issuance by the Company) for any Tranche 2 Notes pursuant to the Securities Purchase Agreement); 


  

	 	(e)	 discontinue any existing line of business of any Group Company or enter into any new line of line of business
by any Group Company; or 


  

	 	(f)	 issue any securities senior to the Ordinary Shares with respect to voting rights, dividends, conversion rights,
redemption rights, liquidation preference or otherwise. 


  

	6.	 Payment of the principal amount and all accrued interest on the Notes may be made by cheque made payable to, or
by bank transfer to an account nominated for the purpose to the Company in writing by, the registered holder or, in the case of joint registered holders, to the one who is first-named on the register, or to such person or persons as the registered
holder or all the joint registered holders may in writing direct and sent to the registered holder or in the case of joint registered holders to that one of the joint registered holders who is first-named on the register or to such address as the
registered holder or joint registered holders may in writing direct. Cheques may be sent through the post at the risk of the registered holder or jointly registered holders and payment of any such cheque by the bankers on whom it is drawn, or a bank
transfer to the relevant account, shall be good discharge to the Company. 



  
 41 














	7.	 If more than one person is entered in the register as joint holders of any Notes then, without prejudice to
paragraph 5 of this Part 3 of Schedule 2, the receipt of any one of such holders for any moneys payable on or in respect of the Notes shall be as effective a discharge to the Company or other person making the payment as if the person signing such
receipt were the sole registered holder of such Notes. 


  

	8.	 If any Certificate is worn out or defaced then, on production of it to the Directors, they may cancel it and
may issue a fresh Certificate in lieu. If any Certificate is lost or destroyed it may be replaced on such terms (if any) as to evidence and indemnity as the Company may reasonably require. An entry recording the issue of the new Certificate and
indemnity (if any) shall be made in the register. No fee shall be charged for the registration of any transfer or for the registration of any probate, letters of administration, certificate of marriage or death, power of attorney or other documents
relating to or effecting title to any Notes. 


  

	9.	 Any notice or other document required to be given under this Instrument shall be in writing and may be given to
or served on any Noteholder by sending it by first-class post in a prepaid envelope addressed to such Noteholder at his registered address. In the case of joint Noteholders, a notice given to, or document served on, the Noteholder whose name stands
first in the register in respect of such Notes shall be sufficient notice to, or service on, all the joint holders. Any such notice sent or document served by first-class post shall be deemed to have been given or served 48 hours or 96 hours in the
case of a notice or document sent to an address for a Noteholder not in the United Kingdom after the time when it is posted and in proving such notice or service, it shall be sufficient to prove that the envelope containing the notice or document
was properly addressed, stamped and posted. 


  

	10.	 Any notice or other document delivered or sent by post to, or left at, the registered address of any Noteholder
in pursuance of these provisions shall, notwithstanding that such Noteholder is then dead or bankrupt or in liquidation, and whether or not the Company has notice of his death or bankruptcy or liquidation, be deemed to have been duly served or
delivered in respect of any Notes registered in the name of such Noteholder as sole or first-named joint holder unless his name shall at the time of the service of the notice or document have been removed from the register as the holder of the
Notes, and such service shall for all purposes be deemed sufficient service of such notice or document on all persons interested (whether jointly with or as claiming through or under him) in the Notes. 



  
 42 














	11.	 A copy of this Instrument shall be kept at the Company’s registered office. A Noteholder (and any person
authorised by a Noteholder) may inspect that copy of the Instrument at all reasonable times during office hours. 


  

	12.	 Each Noteholder by subscribing for and/or holding any Notes pursuant to the terms of this Instrument expressly
and irrevocably agrees that the Group Companies may refinance all or any part of either the Senior Loan or the Novartis Loan Note (either with the existing creditors thereof or with third party creditors) and that, such refinanced loan shall for all
purposes under this Instrument be treated, mutatis mutandis ̧ as the Senior Loan or the Novartis Loan Note (as the case may be) and benefit from any protections, provisions, exemptions or other terms hereof, without requiring the consent
of any Noteholder; provided, that no such refinancing or amendment of the Senior Loan which increases the amount of the principal sum of the Senior Loan owing from time to time above £14 million, or extends the Final Repayment Date for
the Senior Loan beyond 1 March 2022, shall be effective unless otherwise approved by the Noteholder Majority; provided, further, that no such consent or agreement shall be required from any Noteholder Majority from or after the time when
Shareholder Approval has been obtained. For the avoidance of doubt, if any such refinancing takes place, any lenders thereunder shall be treated as the “Senior Lenders” for the purposes of this Instrument. The Company shall as soon as
reasonably practicable after the occurrence of any such refinancing, provide notice of the same to the Noteholders. 


  

	13.	 If the Company, whilst any Notes are outstanding, shall effect a subdivision of its Ordinary Shares, the
Tranche 1 Conversion Price and Tranche 2 Conversion Price (if any) then in effect immediately before that subdivision shall be proportionately decreased. If the Company, whilst any Notes are outstanding, shall combine its Ordinary Shares, the
Tranche 1 Conversion Price and Tranche 2 Conversion Price then in effect immediately before the combination shall be proportionately increased. 


  

	14.	 If the Company, whilst any Notes are outstanding, shall make or issue, or fix a record date for the
determination of holders of its Ordinary Shares entitled to receive a dividend or other distribution to the shareholders from the fund for invested unrestricted equity payable in Ordinary Shares in the Company, then and in each such event the
Tranche 1 Conversion Price and Tranche 2 Conversion Price then in effect immediately before such event shall be decreased as of the time of such issuance or, in the event such a record date shall have been fixed, as of the close of business on such
record date, by multiplying the Tranche 1 Conversion Price or Tranche 2 Conversion Price, as applicable, then in effect by a fraction: 



  
 43 














	 	(a)	 the numerator of which shall be the total number of Ordinary Shares outstanding immediately prior to the time
of such issuance or the close of business on such record date, and 


  

	 	(b)	 the denominator of which shall be the total number of Ordinary Shares outstanding immediately prior to the time
of such issuance or the close of business on such record date plus the number of Ordinary Shares issuable in payment of such dividend or distribution; 



provided, however, that if such record date shall have been fixed and such dividend is not fully paid or if such distribution is not fully made
on the date fixed therefor, the Tranche 1 Conversion Price and Tranche 2 Conversion Price shall be recomputed accordingly as of the close of business on such date and thereafter the Tranche 1 Conversion Price and Tranche 2 Conversion Price shall be
adjusted pursuant to this paragraph as of the time of actual payment of such dividends or distributions, if any. 
  

	15.	 When any adjustment is required to be made in the Tranche 1 Conversion Price or Tranche 2 Conversion Price
pursuant to paragraph 14 or 15, the number of Ordinary Shares issuable upon conversion of a Note shall be calculated by reference to the revised Tranche 1 Conversion Price or Tranche 2 Conversion price following the adjustment made by paragraph 14
or 15. 


  

	16.	 If the Company, whilst any Notes are outstanding, shall: (i) pay or declare a dividend payable to all
shareholders other than in Ordinary Shares (e.g. in cash or assets other than Ordinary Shares in the Company); or (ii) make any distribution of share capital (including share premium account and capital redemption legal reserve), then and in
each such event the Tranche 1 Conversion Price and Tranche 2 Conversion Price then in effect immediately before such event shall be decreased as of such event by multiplying the Tranche 1 Conversion Price or Tranche 2 Conversion Price, as
applicable, then in effect by a fraction: 


  

	 	(a)	 the numerator of which shall be equal to (i) the Closing Price on the day immediately prior to the date
when such event was first published (or if there is no such price, the fair market value of one ordinary share of the Company as of such date as determined in good faith by the Directors) minus (ii) the amount per issued share of such dividend
or distribution; and 


  

	 	(b)	 the denominator of which shall be the Closing Price on the day immediately prior to the date when such event
was first published (or if there is no such price, the fair market value of one ordinary share of the Company as of such date as determined in good faith by the Directors). 



  
 44 













 In the event that the application of the above fraction would result in an increase in the
Conversion Price, then no adjustment shall be made hereunder. If the Company distributes assets other than cash, the amount per outstanding share of the distribution shall be calculated by reference to the fair market value of the assets distributed
as determined in good faith by the Directors. 
  

	17.	 If, prior to the Maturity Date, there shall occur any reorganization, recapitalization, reclassification,
consolidation, merger or demerger involving the Company in which the Company’s Ordinary Shares are converted into or exchanged for securities, cash or other property (other than a transaction covered by paragraphs 14 or 15) (collectively, a
“Reorganization”), then, following such Reorganization, the Noteholders shall receive upon conversion the kind and amount of securities, cash or other property, if any, which the Noteholders would have been entitled to receive
pursuant to such Reorganization if such conversion had taken place immediately prior to such Reorganization. Appropriate adjustment (as determined in good faith by the Directors) shall be made in the application of the provisions set forth herein
with respect to the rights and interests thereafter of the Noteholder, to the end that the provisions set forth in this Instrument (including provisions with respect to changes in and other adjustments of the Tranche 1 Conversion Price and/or
Tranche 2 Conversion Price (as applicable) and the number of Ordinary Shares issuable upon conversion of the Notes) shall thereafter be applicable, as nearly as reasonably may be, in relation to any securities, cash or other property thereafter
deliverable upon the conversion of the Notes. 



  
 45 













 Part 4. ADS Issuance and Delivery Instruction 

[DATE] 
 Citibank, N.A., as Depositary 

388 Greenwich Street 
 New York, New York 10013 

Attn.: Mr. Brian M. Teitelbaum (brian.m.teitelbaum@citi.com) 

With a copy simultaneously delivered to: 
 Citibank, N.A., London
Branch 
 25 Canada Square 
 Canary Wharf 

London E14 5LB, England 
 Attn.: UK Custody Settlements 

Custody Team (uksettlements@citi.com) 
 Re: Issuance and Delivery
Instruction—Mereo BioPharma Group plc (CUSIP No.: 589492107) – Deposit & Hold 
 Dear Sirs: 

Reference is made to the Deposit Agreement, dated as of April 23, 2018, as amended and supplemented from time to time (the “Deposit
Agreement”), by and among Mereo BioPharma Group plc, a public limited company incorporated under the laws of England and Wales and its successors (the “Company”), Citibank, N.A., a national banking association organized and existing
under the laws of the United States of America, as Depositary (the “Depositary”), and all Holders and Beneficial Owners of American Depositary Shares (the “ADSs”) issued thereunder. All capitalized terms used, but not otherwise
defined herein, shall have the meaning assigned thereto in the Deposit Agreement. 
 In accordance with the terms and subject to the
limitations set forth in the Deposit Agreement, promptly following the Depositary’s receipt of confirmation from the Custodian that the Custodian has received a deposit of the number of Shares specified below made by the Company for the benefit
of the undersigned holder thereof (the “Holder” and together with the Company, the “Undersigned”), the Undersigned hereby jointly instruct the Depositary, and the Depositary hereby agrees: 

(i) to promptly accept for deposit the number of Shares and issue the number of ADSs as specified below: 

  
 46 














Number of Shares deposited:                   
                                         
                                         
                                         
                                   Shares 

Number of ADSs (CUSIP No.: 589492107; each ADS representing five (5) Shares to be issued: 

                       
     ADSs             
 and (ii) to promptly
deliver such Program ADSs, as follows: 
  

			
	Name of DTC Participant to which the ADSs are to be delivered:	 	  

		
	DTC Participant Account No.:	 	  

		
	Account No. for recipient of ADSs at DTC Participant (f/b/o/ information):	 	  

		
	Name on whose behalf the above number of ADSs are to be issued and delivered:	 	  

		
	Contact person at DTC Participant:	 	  

		
	Daytime telephone number of contact person at DTC:	 	  


 The Company hereby confirms and certifies that (i) the registration statement on Form F-3 (File No. 333-239708) (the
“Registration Statement”), filed with the U.S. Securities and Exchange Commission (the “Commission”) on July 6, 2020, registers the resale of the above Shares represented by ADSs, such ADSs will be freely transferable
following the issuance thereof by the Depositary, and there are no legal restrictions on subsequent transfers of the ADSs to be issued hereunder under the laws of England and Wales or the United States, (ii) the Registration Statement is
effective under the Securities Act of 1933, as amended (the “Securities Act”), and (iii) no stop order suspending the effectiveness of the Registration Statement has been issued and no proceedings for such purpose have been instituted
or are pending or, to the best knowledge of the Company, are contemplated or threatened by the Commission. 
 The Holder hereby represents and covenants to,
and for the benefit of, the Depositary and Citibank, N.A.—London Branch (the “Custodian”), that (i) the Holder is not an “affiliate” of the Company as that term is defined in Rule 144 promulgated by the Commission under
the Securities Act and has not been an affiliate at any time during the 90 days immediately preceding the date hereof, and (ii) all stamp duty taxes, including, without limitation, the U.K. Stamp Duty Reserve Tax (“SDRT”), will be
paid in full and on a timely basis to the extent such taxes are payable in respect of the deposit of the Shares and the issuance and delivery of the ADSs as contemplated herein. 

Each of the Holder and, to the extent it is not unlawful for the Company to do so under the applicable laws of England and Wales, the Company agrees to
indemnify the Depositary and the Custodian for, and to hold the Depositary and the Custodian harmless against, all losses, liabilities, taxes, charges, penalties or expenses (including reasonable legal fees and disbursements), incurred by the
Depositary and/or by the Custodian or to which the 

  
 47 













 Depositary and/or the Custodian may become subject to and arising directly or indirectly from the failure by
any person to pay (or discharge) any applicable stamp duty taxes, including, without limitation, SDRT, or any other similar duty or tax in connection with the deposit of the Shares and the issuance and delivery of the ADSs as contemplated herein,
save to the extent that such losses, liabilities, taxes, charges, penalties or expenses are due to the negligence or bad faith of the Custodian or the Depositary. 
  

			
	[HOLDER]	  	MEREO BIOPHARMA GROUP PLC
		
	By:                                     
                    	  	By:                                     
                    
	Name:	  	Name:
	Title:	  	Title:


  
 48 













 Schedule 3 Meetings of the Noteholders 

 

	1.	 The Company may at any time convene a meeting of Noteholders. In addition, the Company shall at the written
request of the holders of not less than one-quarter (25%) in nominal amount of the outstanding Notes convene a meeting of the Noteholders. Any meeting shall be held at such place as the Company may designate. 



 

	2.	 At least 14 days’ notice (exclusive of the day on which the notice is served or deemed to be served and of
the day for which notice is given) of every meeting shall be given to the Noteholders. The notice shall specify the place, day and time of the meeting and the general nature of the business to be transacted, but it shall not be necessary (except in
the case of a Special Resolution) to specify in the notice the terms of any resolution to be proposed. The accidental omission to give notice to, or the non- receipt of notice by, any of the Noteholders shall not invalidate the proceedings at any
meeting. A meeting of the Noteholders shall, despite being called at shorter notice than specified above, be deemed to have been duly called if it is agreed in writing by all of the Noteholders. 



 

	3.	 At any meeting the quorum shall be two or more Noteholders holding, or representing by proxy, at least 50.1% in
nominal principal amount of the outstanding Notes. No business (other than choosing a Chairman) shall be transacted at any meeting unless the requisite quorum is present. 



 

	4.	 If a quorum is not present, within half an hour from the time appointed for the meeting, the meeting shall be
dissolved if it was convened on the requisition of Noteholders. In any other case, it shall stand adjourned to such day and time (at least 14 days later, but not more than 28 days later) and to such place as may be appointed by the Chairman. At such
adjourned meeting, two Noteholders present in person (or by proxy) and entitled to vote shall constitute a quorum (whatever the nominal amount of the Notes held by them). At least 14 days’ notice of any adjourned meeting of Noteholders shall be
given (in the same manner mutatis mutandis as for an original meeting). That notice shall state that two Noteholders present in person (or by proxy) at the adjourned meeting (whatever the nominal amount of Notes held by them) shall form a quorum.




  
 49 














	5.	 A person (who may but need not be a Noteholder) nominated by the Company shall be entitled to take the chair at
every such meeting but, if no such person is nominated or if the person nominated is not be present at the meeting within five minutes after the time appointed for holding the meeting, the Noteholders present shall choose one of their number to be
Chairman. Any Director or officer of, any Secretary of, and the solicitors to, the Company and any other person authorised in that behalf by the Company may attend at any such meeting. 



 

	6.	 Each question submitted to a meeting of Noteholders shall, unless a poll is demanded, be decided by a show of
hands. 


  

	7.	 At any meeting of Noteholders unless a poll is demanded by the Chairman or by one or more Noteholders present
in person or by proxy and holding or representing in the aggregate not less than one-twentieth in nominal amount of the outstanding Notes (before or on the declaration of the result of the show of hands), a declaration by the Chairman that a
resolution has been carried by the requisite majority, lost or not carried by the requisite majority shall be conclusive evidence of the fact, without proof of the number or proportion of the votes recorded in favour of or against such resolution.



  

	8.	 If a poll is duly demanded, it shall be taken in such manner and (subject as set out below) either at once or
after an adjournment as the Chairman directs. The result of the poll shall be deemed to be the resolution of the meeting at which the poll was demanded. The demand for a poll shall not prevent the meeting from continuing for the transaction of any
business other than the question on which the poll has been demanded. The demand for a poll may be withdrawn. 


  

	9.	 If there is an equality of votes, whether on a show of hands or on a poll, the Chairman of the meeting shall
not be entitled to a casting vote in addition to the vote(s) (if any) to which he may be entitled as a Noteholder or as a proxy. 


  

	10.	 The Chairman may, with the consent of (and shall if so directed by) any meeting at which a quorum is present,
adjourn the meeting from time to time and from place to place, but no business shall be transacted at any adjourned meeting except business that might lawfully have been transacted at the meeting from which the adjournment took place.



  

	11.	 Any poll demanded at any meeting on the election of a Chairman, or on any question of adjournment, shall be
taken at the meeting without adjournment. 



  
 50 














	12.	 On a show of hands, each Noteholder who is an individual and is present in person or (being a corporation) is
present by its duly authorised representative or by one of its officers as its proxy, shall have one vote. On a poll, each Noteholder present in person or by proxy, shall have one vote for every £1 nominal principal amount of Notes held by him
and a person entitled to more than one vote need not (if he votes) use all his votes or cast all the votes he uses in the same way. 


  

	13.	 In the case of joint registered Noteholders any one of them shall be entitled to vote in respect of such Notes
either in person or by proxy and, in the latter case, as if the joint holder were solely entitled to such Notes. If more than one joint holder is present at any meeting either personally or by proxy that one joint holder so present whose name as
between himself and the other or others present stands first in the register as one of the joint holders shall alone be entitled to vote in person or by proxy. 



 

	14.	 Each instrument appointing a proxy must be in writing and duly executed by the appointor or his duly authorised
attorney or, in the case of a corporation under its common seal or duly executed by a duly authorised attorney or officer. The Chairman may (but shall not be bound to) require evidence of the authority of any attorney or officer. A proxy need not be
a Noteholder. 


  

	15.	 An instrument of proxy shall be in the usual or common form or in any other form that the Directors may accept.
The proxy shall be deemed to include the right to demand or join in demanding a poll. A proxy shall, unless stated otherwise, be valid as well for any adjournment of the meeting as for the meeting to which it relates and need not be witnessed.



  

	16.	 The instrument appointing a proxy, and the power of attorney or other authority (if any) under which it is
signed or a notarially certified copy of such power of attorney or authority, shall be deposited at the place specified in (or in any document accompanying) the notice convening the meeting. If no such place is specified, the proxy shall be
deposited at the registered office of the Company not less than 48 hours before the time appointed for holding the meeting or adjourned meeting or for taking of the poll at which the person named in that instrument proposes to vote. In default, the
instrument of proxy shall not be treated as valid. A vote given in accordance with the terms of an instrument of proxy shall be valid notwithstanding the revocation of the proxy or of the authority under which the proxy is given, unless notification
in writing of the revocation has been received at the registered office of the Company or at such other place (if any) specified for the deposit of instruments of proxy in the notice convening the meeting (or any document accompanying it) 48 hours
before the commencement of the meeting or adjourned meeting or the taking of the poll at which the vote is given. 



  
 51 














	17.	 Without prejudice to any of the powers conferred on the Company under any of the provisions of the Instrument,
a meeting of the Noteholders shall, in addition to any other powers, have the following powers exercisable by Special Resolution: 


  

	 	(a)	 power to sanction the exchange or sale of the Notes for, or the conversion of the Notes into, or the
cancellation of the Notes in consideration of, shares, stock, debenture stock or other obligations or security of the Company or any other company formed or to be formed (provided, in each of the foregoing cases, that such action will be conducted
in accordance with the terms of the Conditions or with the prior written consent of the Company); 


  

	 	(b)	 power to sanction any abrogation, modification or compromise of, or any arrangement in respect of, the
Noteholders’ rights against the Company, provided the same has been previously approved in writing by the Company, whether those rights shall arise under the Instrument, the Notes or otherwise; 



 

	 	(c)	 power to assent to any modification of the provisions contained in the Instrument and the Conditions and to
authorise the Company to execute any supplemental instrument embodying any such modification. Any such modification shall be proposed by the Company; and 


  

	 	(d)	 with the prior written consent of the Company, power to: 



 

	 	(i)	 modify the date fixed for final redemption of the Notes; 



 

	 	(ii)	 reduce or cancel the principal amount payable on the Notes; 



 

	 	(iii)	 reduce the amount payable or modify the method of calculating the amount payable on the Notes; or



  

	 	(iv)	 modify the dates for payment in respect of any interest, on the Notes. 



 

	18.	 A Special Resolution passed at a meeting of the Noteholders shall be binding on all the Noteholders whether or
not they are present at the meeting. Each of the Noteholders shall be bound to give effect to it accordingly. The passing of any such resolution shall be conclusive evidence that the circumstances justify passing it (so that the meeting may
determine without appeal whether or not the circumstances justify passing it). 


  

	19.	 Special Resolution, when used in the Conditions, means a resolution passed at a meeting of the
Noteholders duly convened and held in accordance with the Conditions, and carried by a Noteholder Majority. 



  
 52 














	20.	 A resolution in writing signed by or on behalf of a Noteholder Majority shall, for all purposes, be as valid
and effectual as a Special Resolution passed at a meeting duly convened and held in accordance with the Conditions. Such resolution in writing may be contained in one document or in several documents in similar form, each signed by one or more
Noteholders. 


  

	21.	 Minutes of all resolutions and proceedings at every meeting shall be made and duly entered in books to be from
time to time provided for that purpose by the Company. Any minutes, if purporting to be signed by the Chairman of the meeting or by the Chairman of the next succeeding meeting of the Noteholders, shall be conclusive evidence of the matters stated in
them. Until the contrary is proved, every meeting for which minutes have been made and signed shall be deemed to have been duly held and convened, and all resolutions passed at the meeting to have been duly passed. 



  
 53 













 EXECUTED as a DEED by MEREO BIOPHARMA GROUP PLC 

acting by 
  

                          
                                         
      
 Director/Authorised signatory 
  

                          
                                         
      
 Director/Authorised signatory 
  

					
	  
	 		 	  

	 Witness
	 		 	
			
	 Name:
	 		 	  

			
	 Address:
	 		 	  

			
		 		 	  

			
	 Occupation:
	 		 	  



  
 54 













 SIGNATURES 

THE COMPANY 
 EXECUTED as a DEED by

 MEREO BIOPHARMA GROUP PLC 
  

					
	  
	 		 	Signature of Director
			
	  
	 		 	Name of Director
			
	  
	 		 	Signature of Secretary
			
	  
	 		 	Name of Secretary


  
 8 













 THE NOTEHOLDERS 

EXECUTED as a DEED by 
 ORBIMED PRIVATE INVESTMENTS VII, LP

 By: OrbiMed Capital GP VII LLC, 

its General Partner 
 By: OrbiMed
Advisors LLC, 
 its Managing Member 
  

					
	 By:
	  	  
	  	
		  	Name:	  	
		  	Title:	  	

 Notice details 

Address:                c/o OrbiMed Advisors LLC, 601 

Lexington Avenue, 54th Floor, New York, NY 
 10022 

Email:                   Legal@OrbiMed.com 

Attention:             General Counsel 

  
 9 













 EXECUTED as a DEED by 

ORBIMED PARTNERS MASTER FUND LIMITED 

By: OrbiMed Capital LLC, solely in its 

capacity as Investment Advisor 
  

					
	 By:
	  	  
	  	
		  	Name:	  	
		  	Title:	  	

 Notice details 
 Address:
                c/o OrbiMed Advisors LLC, 
 601 Lexington Avenue, 54th
Floor, New York, 
 NY 10022 
 Email:
                  Legal@OrbiMed.com 
 Attention:             General Counsel 

  
 10 













 EXECUTED as a DEED by 

ORBIMED GENESIS MASTER FUND, L.P. 
 By: OrbiMed Genesis
GP, LLC, its General Partner 
 By: OrbiMed Advisors LLC, its Managing Member 

 

					
	 By:
	  	  
	  	
		  	Name:	  	
		  	Title:	  	

 Notice details 

Address:                 c/o OrbiMed Advisors LLC, 601 

Lexington Avenue, 54th Floor, New York, NY 
 10022 

Email:                     Legal@OrbiMed.com 

Attention:               General Counsel 

  
 11 













 EXECUTED as a DEED by 

667, L.P. 
 By: BAKER BROS. ADVISORS LP, 

management company and investment adviser to 
 667, L.P., pursuant
to authority granted to it by 
 Baker Biotech Capital, L.P., general partner to 

667, L.P., and not as the general partner. 
 By:
                                         
                                         
   

  
 12 













 EXECUTED as a DEED by 

BAKER BROTHERS LIFE SCIENCES, L.P. 
 By: BAKER BROS.
ADVISORS LP, 
 management company and investment adviser to 

Baker Brothers Life Sciences, L.P., pursuant to 
 authority
granted to it by Baker Brothers Life 
 Sciences Capital, L.P., general partner to Baker 

Brothers Life Sciences, L.P., and not as the 
 general partner.

 By:
                                        
                                     

  
 13 













 EXECUTED as a DEED by 

BOXER CAPITAL, LLC 
 acting by 

 

                          
                                   

Director/Authorised signatory 
  

                          
                                   

Director/Authorised signatory 
 Witness: 

 

					
	 Name:
	  	  
	  	
			
	 Address:
	  	  
	  	
			
	 Occupation:
	  	  
	  	
			
		  	  
	  	

 Notice details 
 Address:
            12860 El Camino Real, Suite 300, San Diego, CA 92130 
 Email:
                adavis@tavistock.com 
 Attention:
          Aaron Davis 

  
 14 













 EXECUTED as a DEED by 

MVA INVESTORS, LLC 
 acting by 

 

                          
                               

Director/Authorised signatory 
  

                          
                               

Director/Authorised signatory 
 Witness: 

 

					
	 Name:
	  	  
	  	
			
	 Address:
	  	  
	  	
			
	 Occupation:
	  	  
	  	
			
		  	  
	  	

 Notice details 
 Address:
            12860 El Camino Real, Suite 300, San Diego, CA 92130 
 Email:
                adavis@tavistock.com 
 Attention:
          Aaron Davis 

  
 15 













 EXECUTED as a DEED by 

VIVO CAPITAL FUND IX, L.P. 
 acting by 

 

                          
                               

Director/Authorised signatory 
  

                          
                               

Director/Authorised signatory 
  

					
	 Witness:
	  	  
	  	
			
	 Name:
	  	  
	  	
			
	 Address:
	  	  
	  	
			
		  	  
	  	
			
	 Occupation:
	  	  
	  	

 Notice details 
 Address:
            C/O Vivo Capital LLC 192 
 Lytton Avenue, Palo Alto, CA 94301 

Email:                 legal@vivocapital.com 

Attention:           Legal 

  
 16 













 EXECUTED as a DEED by 

VIVO OPPORTUNITY FUND, L.P. 
 acting by 

 

                          
                               

Director/Authorised signatory 
  

                          
                               

Director/Authorised signatory 
  

					
	 Witness:
	  		  	
			
	 Name:
	  	  
	  	
			
	 Address:
	  	  
	  	
			
		  	  
	  	
			
	 Occupation:
	  	  
	  	

 Notice details 
 Address:
            C/O Vivo Capital LLC 192 
 Lytton Avenue, Palo Alto, CA 94301 

Email:               legal@vivocapital.com 

Attention:         Legal 

  
 17