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# OAR Box 1128 Prepped by Ollie Stewart



# Document

Number: 

# 90 ) 11-1-41

9
Docket Number: 

# A-83-2 2

Printed 4/21/200811:07:14 AM

Sheet 90of 198

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AAS R DOCKE T NON-RECOVER

Y O F USD-INDUCE

D CHANGE

S O F VISUA L EVOKE D POTENTIAL

S I M RAT S
G.WINNEK

E (Medizinische s Institu tfii rUrtwelthygien e a n de rUniversita tDUssel dorf , DUsseldorf , W-German y Airplitude-depressio n o f visua l evoke d brain-potential s (VEP ) wa s foun d i n rat s a tbloo d lead-level s (PbB) i n exces s o f 3 0 pg/d l (Winneke , Act.Nerv.Sup.,1980 , i n press) . Th e presen tstud y wa s designe d t o tes tth e degre e o f recover y o f thi s effect . Thre e group s o f mal e Wistar-rat s (n=10 ) wer e studied : A control grou p (A) , a2nd grou p (B ) wit h onl y materna l Fb-exposur e (220 0 pp m a s lead acetat e i n th e diet ) unti l weanin g a t2 1 d , an d a3r d grou p (C ) wit h additiona l postnata l dietar y Pb-exposur e unti l testin g a tabou t1 2 month s o f age . Thes e diet s ar e know

n t o giv e ris e t o steady-stat e PbB s o f abou t4 0 ug/d l an d cor respondin g brai n lead-levels . Flash-evoke d braih-potential s wer e recorde d frc m striat e corte x via'epidura l electrode s durin g sleep-states . Results : (1 ) Marked amplitude-depressio n wa s foun d i n grou p C-animal s a s canpare d t o controls,thu s confirmin g ou realie rfindings ; (2 ) th e degre e o f amplitude-depressio n wa s a s pronounce d i n grou p B-aniwal h a s I n thos e o f grou p C . Conclusions : Lead-Induce d modification s o f VEP-amplitudes , indicatin g damag e t o th e visua l system , d o ho tsee m t o recover , i f th e exposur e take s plac e durin g th e earl y stage s o f CNS-development ; th e underlyin g dysfunctio n appear s t o b e longlastin g i f no tirreversible .

0.12 4 METHYLMERCUR

YPOISONIN

GI H TH E SUCKLIN

GINFANT L.AMIH-ZAKI 1 , S.B . ELHASSANI 1 . ? ; M.A.MAJEED 1 ; T.W.CLARKSON 2 ; R.A.DOHERTY 2 ; M.R . GREENWOOD 2 »'• ; 1 Universit y o f Baghdad , Iraq ; 2 Universit y o f Rocheste r ,H.Y. , USA ; 3 Spartanbur g Genera l Hospital,S.C.,USA ; ''Xero xCorp. , Rochester , N.Y.,US A I na five yea r logitudina l stud y o f Mother s an

d Infant s exposedto methyl mercury

during th

e Ira qepidemi c o f 1972 , th e frequencie s o f sign s an d symptoms exhibitedb

y th e mother s wer e typica l o f methylmercury poisoning . Whe nblood concentration s o f mercur y ar e correcte dt o Marc h1 , 1972 , mother s wit hth e nos t sevet e sign s an d symptom

s ha d a naverag e bloo

dmercur

y concentration significantl y

higher , p<.01 , thaneithe r th e milde r or asymptomati c groups . Analytica l dat a indicat e tha t th e predominan t rout e o f exposur e fo r th e infan t wa s throug

hbreas t mil k i nwhic happroximatel y 60 % o f tota l mercur y wa s determined , b

y col dvapo r atomi c absorption , t o b e organi c mercury . Abnorma l neurologica l sign s i nthes e infant s becam e mor e obviou s wit htime ; hyper reflexi a wa s observedi nD o f 2 2 infant s a t firs t examination , an d i n1 7 o f 2 2 a t secon

dexamination . Delayed moto r developmen t becam e eviden t a t the secon d an dthir dexaminations . The frequency o f pathologica l reflexes , delayedmoto r developmenta l milestone s an d nocturna l enuresi s wer e al l s o higha s t o b e considere dsignifican t eveni nth e absenc e o f a controlledstudy . Ther e wa s no increas e i nmortalit y a s comparedt o a contro l group .

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