Exhibit 10.4PROMISSORY NOTESeptember 12, 2007FOR VALUE RECEIVED, ENTREMED, INC., a Delaware corporation located at the address stated below(“Borrower”), promises to pay to the order of OXFORD FINANCE CORPORATION, a Delawarecorporation or any subsequent holder hereof (each, a “Lender”), the principal sum of FIVEMILLION and 00/100 Dollars ($5,000,000.00).This Promissory Note is issued pursuant to that certain Loan and Security Agreement, dated as ofSeptember 12, 2007, among Borrower, the other Loan Parties signatory thereto, General ElectricCapital Corporation, as agent and lender, the other lenders signatory thereto, and Lender (asamended, restated, supplemented or otherwise modified from time to time, the “Agreement”),is one of the Notes referred to therein, and is entitled to the benefit and security of the DebtDocuments referred to therein, to which Agreement reference is hereby made for a statement of allof the terms and conditions under which the loans evidenced hereby were made. All capitalizedterms, unless otherwise defined herein, shall have the respective meanings assigned to such termsin the Agreement.The principal amount of the indebtedness evidenced hereby shall be payable in the amounts and onthe dates specified in the Agreement. Interest thereon shall be paid until such principal amountis paid in full at such interest rates and at such times as are specified in the Agreement. Theterms of the Agreement are hereby incorporated herein by reference.All payments shall be applied in accordance with the Agreement. The acceptance by Lender of anypayment which is less than payment in full of all amounts due and owing at such time shall notconstitute a waiver of Lender’s right to receive payment in full at such time or at any prior orsubsequent time. The payment of any Scheduled Payment prior to its due date shall result in acorresponding increase in the portion of the Scheduled Payment credited to the remaining unpaidprincipal balance.All amounts due hereunder and under the other Debt Documents are payable in the lawful currency ofthe United States of America. Borrower hereby expressly authorizes Lender to insert the date valueis actually given in the blank space on the face hereof and on all related documents pertaininghereto.This Note is secured as provided in the Agreement and the other Debt Documents. Reference ishereby made to the Agreement and the other Debt Documents for a description of the properties andassets in which a security interest has been granted, the nature and extent of the securityinterest, the terms and conditions upon which the security interest was granted and the rights ofthe holder of the Note in respect thereof.Time is of the essence hereof. If Lender does not receive from Borrower payment in full of anyScheduled Payment or any other sum due under this Note or any other Debt Document within 3 daysafter its due date, Borrower agrees to pay the Late Fee in accordance with the Agreement. SuchLate Fee will be immediately due and payable, and is in addition to any other costs, fees andexpenses that Borrower may owe as a result of such late payment.This Note may be voluntarily prepaid only as permitted under Section 2.4 of the Agreement. Afteran Event of Default, this Note shall bear interest at a rate per annum equal to the Default Ratepursuant to Section 2.6 of the Agreement.

 
Borrower and all parties now or hereafter liable with respect to this Note, hereby waivepresentment, demand for payment, notice of nonpayment, protest, notice of protest, notice ofdishonor, and all other notices in connection herewith, as well as filing of suit (if permitted by law) and diligence incollecting this Note or enforcing any of the security hereof, and agree to pay (if permitted bylaw) all expenses incurred in collection, including reasonable attorneys’ fees and expenses,including allocable costs of in-house counsel.**THIS NOTE SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF NEW YORK.**No variation or modification of this Note, or any waiver of any of its provisions or conditions,shall be valid unless such variation or modification is made in accordance with Section 10.8 of theAgreement. Any such waiver, consent, modification or change shall be effective only in thespecific instance and for the specific purpose given.*[Remainder of page left intentionally blank; Signature page follows]*

 
**IN WITNESS WHEREOF**, Borrower has duly executed this Note as of the date first above written.       ENTREMED, INC.       By:       Name: James S. Burns  Title: President and Chief Executive Officer  Federal Tax ID #: 58-1959440  Address: 9460 Medical Center Drive             Rockville, Maryland 20850Signature Page