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Exhibit 4.1 ARTICLES OF AMENDMENT
TO
CERTIFICATE OF DESIGNATIONS OF
SERIES F CONVERTIBLE PREFERRED STOCK
OF
DIAMETRICS MEDICAL, INC. 1. The name of the corporation is Diametrics Medical, Inc. 2. The following is the full and complete text of the first sentence of
subsection (i) of paragraph (d) of the Certificate of Designations of Series F
Convertible Preferred Stock of Diametrics Medical, Inc., as amended: (i) Preference upon Liquidation, Dissolution or Winding Up. In the event
of any dissolution or winding up of the Corporation, whether voluntary or
involuntary, holders of each outstanding share of Series F Preferred Stock
shall be entitled, after any payments due to the holders of any outstanding
shares of Series G Convertible Preferred Stock, to be paid first out of the
assets of the Corporation available for distribution to shareholders, whether
such assets are capital, surplus or earnings, an amount equal to $100 (the
Series F Purchase Price) per share of Series F Preferred Stock held (as
adjusted for any stock splits, stock dividends or recapitalizations of the
Series F Preferred Stock) and any declared but unpaid dividends on such share,
before any payment shall be made to the holders of the Common Stock, or any
other stock of the Corporation ranking junior to the Series F Preferred Stock
with regard to any distribution of assets upon liquidation, dissolution or
winding up of the Corporation. 3. The foregoing amendment has been adopted pursuant to Chapter 302A of the
Minnesota Business Corporation Act. IN WITNESS WHEREOF, the undersigned, the Secretary of Diametrics Medical,
Inc., being duly authorized on behalf of Diametrics Medical, Inc., has executed
this document on this 3rd of October, 2004. /s/ Kenneth L. CutlerKenneth L. CutlerSecretary




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CERTIFICATE OF DESIGNATIONS OF
SERIES F CONVERTIBLE PREFERRED STOCK
OF
DIAMETRICS MEDICAL, INC.
a Minnesota corporation (as amended October 3, 2004) The undersigned, being the duly elected and acting Chief Executive Officer
of Diametrics Medical, Inc., a Minnesota corporation (the Corporation),
hereby certifies that pursuant to the authority contained in Article 3 of the
Corporations Amended and Restated Articles of Incorporation, as amended, and
in accordance with the provisions of Minnesota Statutes, Section 302A.401,
Subd. 3(b), the Corporations Board of Directors has adopted the following
resolutions creating a series of its Preferred Stock designated as Series F
Convertible Preferred Stock: WHEREAS, the Corporations Amended and Restated Articles of Incorporation
provides for a class of shares known as Preferred Stock, issuable from time to
time in one or more series; and WHEREAS, the Board of Directors of the Corporation is authorized to
determine or alter the rights, preferences, privileges and restrictions granted
to or imposed upon any wholly unissued shares of Preferred Stock, to fix the
number of shares constituting any such series, and to determine the designation
thereof, or any of any of them. NOW, THEREFORE, BE IT RESOLVED, that the Board of Directors hereby fixes
and determines the designations of, the number of shares constituting, and the
rights, preferences, privileges and restrictions relating to, a new series of
Preferred Stock as follows: (a) Designation. The series of Preferred Stock is hereby designated
Series F Convertible Preferred Stock (the Series F Preferred Stock). (b) Authorized Shares. The number of authorized shares constituting the
Series F Preferred Stock shall be 30,000 shares of such series. (c) Dividends. Subject to the prior rights of holders of all classes of
stock at the time outstanding having prior rights as to dividends, the holder
of the Series F Preferred Stock shall be entitled to receive, when, as and if
declared by the Board of Directors, out of any assets of the Corporation
legally available therefor, such dividends as may be declared from time to time
by the Board of Directors. (d) Liquidation Preference. (i) Preference upon Liquidation, Dissolution or Winding Up. In the event
of any dissolution or winding up of the Corporation, whether voluntary or
involuntary, holders of each outstanding share of Series F Preferred Stock
shall be entitled, after any payments due to the holders of any outstanding
shares of Series G Convertible Preferred Stock, to be paid first out of the
assets of the Corporation available for distribution to shareholders, whether
such assets are capital, surplus or earnings, an amount equal to $100 (the
Series F Purchase Price) per share of Series F Preferred Stock held (as
adjusted for any stock splits, stock dividends or recapitalizations of the
Series F Preferred Stock) and any declared but unpaid dividends on such share,
before any payment shall be made to the holders of the Common Stock, or any
other stock of the Corporation ranking junior to the Series F Preferred Stock
with regard to any distribution of assets upon liquidation, dissolution or
winding up of the Corporation. The holders of the Series F Preferred Stock
shall be entitled to share ratably, in accordance with the respective
preferential amounts payable on such stock, in any distribution which is not
sufficient to pay in full the aggregate of the amounts payable thereon. If,
upon any liquidation, dissolution or winding up of the Corporation, the assets
to be distributed to the holders of the Series F Preferred Stock shall be
insufficient to permit payment to such shareholders of the full preferential
amounts aforesaid, then all of the assets of the Corporation available for
distribution to shareholders shall be distributed to the holders of Series F
Preferred Stock. Each holder of the Series 2




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F Preferred Stock shall be entitled to receive that portion of the assets
available for distribution as the number of outstanding shares of Series F
Preferred Stock held by such holder bears to the total number of shares of
Series F Preferred Stock. Such payment shall constitute payment in full to the
holders of the Series F Preferred Stock upon the liquidation, dissolution or
winding up of the Corporation. After such payment shall have been made in
full, or funds necessary for such payment shall have been set aside by the
Corporation in trust for the account of the holders of Series F Preferred
Stock, so as to be available for such payment, such holders of Series F
Preferred Stock shall be entitled to no further participation in the
distribution of the assets of the Corporation. (ii) Consolidation, Merger and Other Corporate Events. A consolidation or
merger of the Corporation (except into or with a subsidiary corporation) or a
sale, lease, mortgage, pledge, exchange, transfer or other disposition of all
or substantially all of the assets of the Corporation or any reclassification
of the stock of the Corporation (other than a change in par value or from no
par to par, or from par to no par or as the result of an event described in
subsections (iv) through (vii) of paragraph (f)), shall be regarded as a
liquidation, dissolution or winding up of the affairs of the Corporation within
the meaning of this paragraph (d). In no event shall the issuance of new
classes of stock, whether senior, junior or on a parity with the Series F
Preferred Stock, be deemed a reclassification under or otherwise limited by
the terms hereof. (iii) Distribution of Cash and Other Assets. In the event of a
liquidation, dissolution or winding up of the Corporation resulting in the
availability of assets other than cash for distribution to the holders of the
Series F Preferred Stock, the holders of the Series F Preferred Stock shall be
entitled to a distribution of cash and/or assets equal to the value of the
liquidation preference stated in subsection (i) of this paragraph (d), which
valuation shall be made solely by the Board of Directors, and provided that
such Board of Directors was acting in good faith, shall be conclusive. (iv) Distribution to Junior Security Holders. After the payment or
distribution to the holders of the Series F Preferred Stock of the full
preferential amounts aforesaid, the holders of the Common Stock then
outstanding, or any other stock of the Corporation ranking as to assets upon
liquidation, dissolution or winding up of the Corporation junior to the Series
F Preferred Stock, shall be entitled to receive ratably all of the remaining
assets of the Corporation. (v) Preference; Priority. References to a stock that is senior to, on a
parity with or junior to other stock as to liquidation shall refer,
respectively, to rights of priority of one series or class of stock over
another in the distribution of assets on any liquidation, dissolution or
winding up of the Corporation. The Series F Preferred Stock shall be senior to
the Common Stock of the Corporation and senior to any subsequent series of
Preferred Stock issued by the Corporation. (e) Voting Rights. Except as otherwise required by law, the holder of
shares of Series F Preferred Stock shall not have the right to vote on matters
that come before the shareholders. (f) Conversion Rights. The holders of Series F Preferred Stock will have
the following conversion rights: (i) Right to Convert. Subject to and in compliance with the provisions of
this paragraph (g), any issued and outstanding shares of Series F Preferred
Stock may, at the option of the holder, be converted at any time or from time
to time into fully paid and nonassessable shares of Common Stock at the
conversion rate in effect at the time of conversion, determined as provided
herein; provided, that a holder of Series F Preferred Stock may at any given
time convert only up to that number of shares of Series F Preferred Stock so
that, upon conversion, the aggregate beneficial ownership of the Corporations
Common Stock (calculated pursuant to Rule 13d-3 of the Securities Exchange Act
of 1934, as amended) of such holder and all persons affiliated with such holder
is not more than 9.99% of the Corporations Common Stock then outstanding. 3




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(ii) Mechanics of Conversion. Before any holder of Series F Preferred
Stock shall be entitled to convert the same into shares of Common Stock, he
shall surrender the certificate or certificates therefor, duly endorsed, at the
office of the Corporation or of any transfer agent for the Common Stock, and
shall give written notice to the Corporation at such office that he elects to convert the
same and shall state therein the number of shares of Series F Preferred Stock
being converted. Thereupon, the Corporation shall promptly issue and deliver
at such office to such holder of Series F Preferred Stock a certificate or
certificates for the number of shares of Common Stock to which he shall be
entitled. Such conversion shall be deemed to have been made immediately prior
to the close of business on the date of such surrender of the shares of Series
F Preferred Stock to be converted, and the person or persons entitled to
receive the shares of Common Stock issuable upon such conversion shall be
treated for all purposes as the record holder or holders of such shares of
Common Stock on such date. (iii) Conversion Price. The number of shares into which one share of
Series F Preferred Stock shall be convertible shall be determined by dividing
$100 (the Series F Purchase Price) by the then existing Conversion Price (as
set forth below), which shall be subject to adjustment from time to time in
certain instances, as provided below in this paragraph (g)(iii) (the
Conversion Ratio). The Conversion Price per share for the Series F
Preferred Stock shall be equal to 75% of the Market Price (as defined below and
subject to adjustment as described below), rounded to the nearest penny;
provided, however, that in no event shall the Conversion Price be less than
$0.20 per share (subject to adjustment as provided below) (the Floor Price)
or exceed the lower of (x) $0.25 per share or (y) the average of the last 20
closing prices of the Common Stock on the trading days immediately preceding
the Original Issue Date, as defined below (the Ceiling Price). Both the
Floor Price and Ceiling Price shall be further adjusted upon the occurrence of
any event in paragraph (f)(iv)-(x). For purposes of determining the Conversion Price, the Market Price shall
equal the volume weighted average trading price of the lowest 3 inter-day
trading prices of the Common Stock, as obtained from Bloomberg Financial
Services or another similar service, for the five consecutive trading days
immediately preceding the conversion date (which may include trading days prior
to the date the Series F Preferred Stock is first issued (the Original Issue
Date)). For purposes of illustration only, if the Market Price is $0.27 and the
Ceiling Price is in excess of $0.2025 at time of conversion, the Conversion
Ratio will be $100/$0.2025 = 493.83 to 1, allowing the 30,000 shares of Series
F Preferred Stock to be converted into 14,814,900 shares of Common Stock. On
the other hand, if the Market Price is $1.00 and the Ceiling Price is in excess
of $0.25 at time of conversion, the Conversion Ratio will be $100/$0.25 = 400
to 1, allowing the 30,000 shares of Preferred Stock to be converted into
12,000,000 shares of Common Stock. Similarly, if the Market Price is $0.05 at
time of conversion, the Conversion Ratio will be $100/$0.20 = 500 to 1,
allowing the 30,000 shares of Preferred Stock to be converted into 15,000,000
shares of Common Stock, the maximum number of shares of Common Stock into which
the Series F Preferred Stock may be converted. (iv) Adjustment for Stock Splits and Combinations. If the Corporation
shall at any time, or from time to time after the Original Issuance Date,
effect a subdivision of the outstanding Common Stock, the Conversion Price in
effect immediately prior thereto shall be proportionately decreased, and
conversely, if the Corporation shall at any time or from time to time after the
Original Issuance Date combine the outstanding shares of Common Stock, the
Conversion Price then in effect immediately before the combination shall be
proportionately increased. Any adjustment under this paragraph (f)(iv) shall
become effective at the close of business on the date the subdivision or
combination becomes effective. (v) Adjustment for Certain Dividends and Distributions. In the event the
Corporation at any time, or from time to time after the Original Issuance Date,
shall make or issue, or fix a record date for the determination of holders of
Common Stock entitled to receive, a dividend or other distribution payable in
additional shares of Common Stock, then and in each such event the Conversion
Price for the Series F Preferred Stock then in effect shall be decreased as of
the time of such issuance or, in the event such a record date shall have been
fixed, as of the close of business on such record date, by multiplying the
Conversion Price for such Series F Preferred Stock then in effect by a
fraction: 4




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(A) the numerator of which shall be the total number of shares of
Common Stock issued and outstanding immediately prior to the time of such
issuance or the close of business on such record date, and (B) the denominator of which shall be the total number of shares of
Common Stock issued and outstanding immediately prior to the time of such
issuance or the close of business on such record date plus the number of
shares of Common Stock issuable in payment of such dividend or
distribution; provided, however, if such record date shall have been fixed and such dividend
is not fully paid or if such distribution is not fully made on the date fixed
therefor, the Conversion Price for the Series F Preferred Stock shall be
recomputed accordingly as of the close of business on such record date and
thereafter, the Conversion Price for the Series F Preferred Stock shall be
adjusted pursuant to this paragraph (f)(v) as of the time of actual payment of
such dividends or distributions. (vi) Adjustments for Other Dividends and Distributions. In the event the
Corporation at any time or from time to time after the Original Issuance Date
shall make or issue, or fix a record date for the determination of holders of
Common Stock entitled to receive, a dividend or other distribution payable in
securities of the Corporation other than shares of Common Stock, then and in
each such event provision shall be made so that the holders of such Series F
Preferred Stock shall receive upon conversion thereof in addition to the number
of shares of Common Stock receivable thereupon, the amount of securities of the
Corporation that they would have received had their Series F Preferred Stock
been converted into Common Stock on the date of such event and had thereafter,
during the period from the date of such event to and including the conversion
date, retained such securities receivable by them as aforesaid during such
period giving application to all adjustments called for during such period
under this paragraph (f) with respect to the rights of the holders of the
Series F Preferred Stock. (vii) Adjustment for Reclassification Exchange or Substitution. If the
Common Stock issuable upon the conversion of the Series F Preferred Stock shall
be changed into the same or a different number of shares of any class or
classes of stock, whether by capital reorganization, reclassification or
otherwise (other than a subdivision or combination of shares or stock dividend
provided for above, or a reorganization, merger, consolidation or sale of
assets provided for elsewhere in this paragraph (f)), then and in each such
event the holder of each share of Series F Preferred Stock shall have the right
thereafter to convert such share into the kind and amount of shares of stock
and other securities and property receivable upon such reorganization,
reclassification or other change, by holders of the number of shares of Common
Stock into which such shares of Series F Preferred Stock might have been
converted immediately prior to such reorganization, reclassification, or
change, all subject to further adjustment as provided herein. (viii) Adjustment for Event of Default.Upon (A) commencement by the
Corporation of a voluntary case or proceeding under the bankruptcy laws, (B)
the Corporations failure to discharge or stay a bankruptcy proceeding within
60 days of such action being taken against the Corporation, (C) the
Corporations failure to file the First Registration Statement with the SEC
within 30 days of the Closing Date, other than due to a delay not caused by the
Corporation or (D) the de-listing of the Corporations Common Stock from the
OTC Bulletin Board (as such terms are defined in that certain Subscription
Agreement dated January 14, 2004 by and among the Corporation and the
purchasers named therein), the Conversion Price shall be adjusted to 65% of the
Market Price, rounded to the nearest penny. (ix) Adjustment of Floor Price.If the Corporations cash flow is at
least 20% lower than the six month forward cash flow plan provided to the
purchasers of the Series F Preferred Stock on the Closing Date, the Floor Price
will be decreased from $0.20 to $0.15. 5




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(x) Reorganization, Mergers, Consolidations or Sales of Assets. If at any
time or from time to time there shall be a capital reorganization of the Common
Stock (other than a subdivision, combination, reclassification or exchange of
shares provided for elsewhere in this paragraph (f)) or a merger or
consolidation of the Corporation with or into another corporation, or the sale
of all or substantially all of the Corporations properties and assets to any
other person, then, as a part of such reorganization, merger, consolidation or
sale, provision shall be made so that the holders of the Series F Preferred
Stock shall thereafter be entitled to receive upon conversion of such Series F
Preferred Stock, the number of shares of stock or other securities or property
of the Corporation or of the successor corporation resulting from such merger
or consolidation or sale, to which a holder of Common Stock deliverable upon
conversion would have been entitled on such capital reorganization, merger,
consolidation or sale. In any such case, appropriate adjustment shall be made in the application
of the provisions of this paragraph (f) with respect to the rights of the
holders of the Series F Preferred Stock after the reorganization, merger,
consolidation or sale to the end that the provisions of this paragraph (f)
(including adjustment of the Conversion Price then in effect and the number of
shares purchasable upon conversion of the Series F Preferred Stock) shall be
applicable after that event as nearly equivalent as may be practicable. (xi) Certificate of Adjustment. In each case of an adjustment or
readjustment of the Conversion Price for the number of shares of Common Stock
or other securities issuable upon conversion of the Series F Preferred Stock,
the Corporation shall compute such adjustment or readjustment in accordance
herewith and the Corporations Chief Financial Officer shall prepare and sign a
certificate showing such adjustment or readjustment, and shall mail such
certificate by first class mail, postage prepaid, to each registered holder of
the Series F Preferred Stock at the holders address as shown in the
Corporations books. The certificate shall set forth such adjustment or
readjustment, showing in detail the facts upon which such adjustment or
readjustment is based. (xii) Notices of Record Date. In the event of (A) any taking by the
Corporation of a record of the holders of any class or series of securities for
the purpose of determining the holders thereof who are entitled to receive any
dividend or other distribution or (B) any reclassification or recapitalization
of the capital stock of the Corporation, any merger or consolidation of the
Corporation or any transfer of all or substantially all of the assets of the
Corporation to any other corporation, entity or person, or any voluntary or
involuntary dissolution, liquidation or winding up of the Corporation, the
Corporation shall mail to each holder of Series F Preferred Stock at least 10
days prior to the record date specified therein, a notice specifying (1) the
date on which any such record is to be taken for the purpose of such dividend
or distribution and a description of such dividend or distribution, (2) the
date on which any such reorganization, reclassification, transfer,
consolidation, merger, dissolution, liquidation or winding up is expected to
become effective and (3) the time, if any is to be fixed, as to when the
holders of record of Common Stock (or other securities) shall be entitled to
exchange their shares, of Common Stock (or other securities) for securities or
other property deliverable upon such reorganization, reclassification,
transfer, consolidation, merger, dissolution, liquidation or winding up. (xiii) Fractional Shares. No fractional shares of Common Stock shall be
issued upon conversion of the Series F Preferred Stock. In lieu of any
fractional shares to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to the product of such fraction multiplied by
the fair market value of one share of the Corporations Common Stock on the
date of conversion, as determined in good faith by the Board of Directors. (xiv) Reservation of Stock Issuable Upon Conversion. The Corporation
shall at all times reserve and keep available out of its authorized but
unissued shares of Common Stock, solely for the purpose of effecting the
conversion of the shares of the Series F Preferred Stock, such number of its
shares of Common Stock as shall from time to time be sufficient to effect the
conversion of all outstanding shares of Series F Preferred Stock, and if at any
time the number of authorized but unissued shares of Common Stock shall not be
sufficient to effect the conversion of all then outstanding shares of Series F
Preferred Stock, the Corporation will take such corporate action as may, in the
opinion of its counsel, be necessary to increase its authorized but unissued
shares of Common Stock to such number of shares as shall be sufficient for such
purpose. 6




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(xv) Notices. Any notice required by the provisions of this paragraph (f)
to be given to the holders of shares of Series F Preferred Stock shall be
deemed given (A) if deposited in the United States mail, postage prepaid, or
(B) if given by any other reliable or generally accepted means (including by
facsimile or by a nationally recognized overnight courier service), in each
case addressed to each holder of record at his address (or facsimile number)
appearing on the books of the Corporation. (xvi) Payment of Taxes. The Corporation will pay all transfer taxes and
other governmental charges that may be imposed in respect of the issue or
delivery of shares of Common Stock upon conversion of shares of Series F
Preferred Stock. (xvii) No Dilution or Impairment. The Corporation shall not amend its
Articles of Incorporation or participate in any reorganization, transfer of
assets, consolidation, merger, dissolution, issue or sale of securities or any
other voluntary action, for the purpose of avoiding or seeking to avoid the
observance or performance of any of the terms to be observed or performed
hereunder by the Corporation, without the approval of a majority of the then
outstanding Series F Preferred Stock. (g) No Reissuance of Preferred Stock. Any shares of Series F Preferred
Stock acquired by the Corporation by reason of purchase, conversion or
otherwise shall be canceled, retired and eliminated from the shares of Series F
Preferred Stock that the Corporation shall be authorized to issue. All such
shares shall upon their cancellation become authorized but unissued shares of
Preferred Stock and may be reissued as part of a new series of Preferred Stock
subject to the conditions and restrictions on issuance set forth in the
Articles of Incorporation or in any certificate of designation creating a
series of Preferred Stock or any similar stock or as otherwise required by law. (h) Severability. If any right, preference or limitation of the Series F
Preferred Stock set forth herein is invalid, unlawful or incapable of being
enforced by reason of any rule, law or public policy, all other rights,
preferences and limitations set forth herein that can be given effect without
the invalid, unlawful or unenforceable right, preference or limitation shall
nevertheless remain in full force and effect, and no right, preference or
limitation herein shall be deemed dependent upon any other such right,
preference or limitation unless so expressed herein. 7