SAT Report

PMN Number: P-13-0374

SAT Date: 4/16/2013

Print Date: 7/1/2013

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 2

 Persistence Bioaccum Toxicity Comments

2 12

Exposure Based Review:

Health: No

Ecotox: Yes

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: DEVEL

NEURO

DEVEL NEURO

SYSTOX

MARG ONCO

AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-13-0374

FATE: 

Solid with MP = 165 C (M)

log Kow = 0.72 (E) 

S = 2.48 g/L at 25 C (M)
VP = 3.7E-6 torr at 25 C (E)

BP = Dec. 432 C (M)

H < 1.00E-8 (E)

log Koc = 1.02 (E)

log Fish BCF = 0.50 (E)

log Fish BAF = 0.02 (E) 

POTW removal (%) = 0 

Time for complete ultimate aerobic biodeg = mo

Sorption to soils/sediments = low - moderate

PBT Potential: P2B1

*CEB FATE: Migration to ground water = moderate - rapid

 Health:

 Health Summary: Absorption of the neat material is nil through the skin, 

while absorption is poor through the skin for the material in solution, based on physical/chemical 

properties. Absorption is good through the lung and GI tract, based on test data. There are 

concerns for systemic and developmental toxicities, neurotoxicity, and 

developmental-neurotoxicity, as well as a marginal concern for oncogenicity, based on test data 

for the 

 Test Data: Included on 8/10/05 Conditional Registration Fact Sheet 

for 

Rat systox/neurotox NOAEL 1000 mg/kg, based on clinical observations at 2000 mg/kg;

Rat development NOAEL =>500 mg/kg, with maternal toxic effects at 500 mg/kg and 750 

mg/kg;

Dog 90-day oral toxicity NOAEL 282 mg/kg (M), 232 mg/kg (F) with systemic effects to the 

stomach and intastines;

Rat chronic feeding study NOAEL 50 mg/kg, based on effects to the cecum, mucosal epithelium 

hyperplasia, and decreased body weights at 500 mg/kg;

Chronic (1Yr) feeding study in dogs: NOAEL 99 mg/kg (M), 93 mg/kg (F), LOAEL 967 mg/kg 

(M), 1038 mg/kg (F) with systemic effects to the stomach and GI, and hyperplasia in the 

mucosal epithelium;

Chronic RfD 0.5 mg/kg, based on rat combined chronic toxicity/carcinogenicity NOAEL 50 

mg/kg

Submitted with 

Acute oral study in bobwhite quail: neurotoxicity LOEL 63 mg/kg, with increasing lethargy, 

uncoordination, prostration, loss of righting reflex, rigidity, and convulsions 

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 >100 >100

daphnid 48-h LC50 15.2 >98.6

green algal 96-h EC50 47.6 30
fish _ chronic value >10 1.8

daphnid _ chronic 

value

0.599 >102

algal _ chronic 

value

>10 23

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for 

group; SAR chemical class = MW 207; solid with mp = 162-165 oC 

(M); pH7; effective concentrations based on 100% active ingredients and mean measured 

concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

180

SARs

SAR Class

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat