### UNITED ST ATES ENVIRONMENTAL PROTE C TION AGEN C Y

WASHINGTON

, D.C

. 20 460

OFF IC E O F C HEMI CA L SAFE TY AN D

P O LL U T I O N PRE V ENT I ON



### M E MORA N D U M

D ate : February 4

, 2016



### S U BJ EC T : Co um a ph o s : Acute and Steady State Agg re ga te D i e t a ry (Food and Drinkin g

W ate r ) Exposure an d Ri sk Assessme nt s to Suppo rt R eg i s trati on R eview

.



### F R OM :

THRO UG H: P C Co d e: 036 50 I



### D e ci s ion N o

. : 475453



### P e t i t i o n No

. : N A

R i s k Assess m e n t T y p e: D i eta r y


### TX R No .: NA

MRI D No

. : NA

She ila Piper,

# ~~~ Ri s k Assessmen t Bran c h V I 

### DP Barco d c : 0 4 1 2 87 0



### Re g i s t r at i o n N o. : NA

Re g ul ator y Act i o n : R eg i s trati o n

R eview



### C a s e N o

. : NA

CA S No. : 95266 -4 0-3



### -t O C FR : § 180. l 89

I l ea lth Effec t s Division (7509 P )

### ~ 

### §?

.**~ ~** 

Thurston Mor t on

. Senior

### Ch~**t ~**  ./

David Hrd y, Sen i o r Bi o l og i st 

# bp;/tt(j;fftllf ti;i · · , /

Julie Y a n A l stine, MPH

,

# Env**ronm~~ta' I**  H iaf th i cn ti s t

# ~\.,,v- \J 

# r-...*1-.-

Dietary Exposure Science Adv i sory Council ( D ESAC)

And

Donna D av i s
, Branch C hi ef

Risk Assess m e nt Branch Y I

, 1 I E D (7509 P )



### T O : Bri a n K e n!

, Chemical Review Ma na ger

T o m M ye r s, Team Lead e r
Kevin Cos t e ll o, Branch C hi ef

Risk Ma n ageme nt and Implem e nt at i on Bran c h I V

P es t i cid e Re

- eva l u a t i on Divi s i o n ( 7508P )



### E x e c uti v e S u m m ary

Co umapho s i s a n o r ganophosphate (OP) acaric i de t hat i s app l i e d dir ec t l y t o anima l s. i n cluding dairy cattle

, beef ca ttl e
, h orses

. and sw in e bedding. The chemical i s also e m be dd ed into ca ttl e

ear t ags a nd bee hi ve s trip s

. Acute and s tead y s tat e agg reg a t e dietar y (food a nd drink i n g water)

ex p os ur e and ri sk assess m e nt s fo r c o um a ph os were conducted usin g the Di eta r y Exposu r e

Pa ge I of27

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 2 of 27 

### Evaluation Model (DEEM) software with the Food Commodity Intake Data base ( FCID)

. This

model use s 2003

- 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA ). Th ese analyses were performed to update the latest consumption data and drinking water estimates to support registration review. This memorandum was reviewed by two

peer re viewers o f the DE SAC per the current DESAC Standard Operating Procedure (SOP)

2012.1

.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

Coumaphos is registered for use in beehives and on livestock commodities. The partially refined

acute and two

- day average dietary exposure assessment s were conducted to estimate the dietary exposure and risk associated with registration review . The dietary exposure assessment s incorporated USDA Pesticide Data Program ( PDP ) monitoring data fo r coumaphos and its metabolite ( coumaphoxon ) in/on honey, milk

, and livestock commodities . The dietary exposure

assessment assumes a 50x toxicity adjustment factor ( TAF ) for coumaphoxon in drinking water

, DEEM default processing factors

, and 100% crop treated (CT)

. The drinking water assessment assumed that during a rain event, coumaphos wash

- off from treated cattle can be potentially adsorbed into manure as well as transported as effluent from concentrated animal feeding operations and pastur e/rangeland . U se of this product is restricted to employees of the USDA

APHIS 1 

### who are enrolled in the USDA

- APHIS cholinesterase monitoring program . The USDA’s Cattle Fever Tick Eradication Program (CFTEP) uses this product solely in Texas. As a
result, these maximum application rates were used to assess exposures in drinking water sources in Texas only. The results from the 2% wash

- off fraction after 24 ho urs dip

- vat treatment are shown below for acute and steady state dietary assessments.

Acute assess ments were conducted for food only, drinking water only, and for food and drinking water to characterize dietary exposure. The acute aggregate dietary exposure estimates are below

HED’s level of concern ( < 100 % of the acute population adjusted dose ( aPAD) ) for the U.S. population and all population subgroups. The food only dietary exposure estimate is 50 % of the acute population adjusted dose (aPAD) for the U.S. population , and 98% of the aPAD for

children 3

- 5 years old, the most highly exposed population subgroup at the 99.9 th 

### perce ntile . The drinking water only, dietary exposure estimate is 7 % of the aP AD for the U.S. population, and

2 0 % of the aPAD for all infants (<1 years old), the most highly

- exposed population subgroup, at

the 99.9 th 

### percentile. Co mbined dietary exposure from food and drinking water at the 99.9 th


### percentile of exposure is 51 % of the a PAD for the U.S. population and 99 % of the aPAD for

children 3

- 5 years

, the most highly exposed population subgroup. Beef meat is the risk driver when combining food in the acute assessment for coumaphos, accounting for approximately 8 0% of estimated exposure in the acute assessment based upon critical exposure contribution analysis.

1 APHIS

- Animal and Plant Health Inspection Service

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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### Steady State Average Dietary (Fo od and Drinking Water ) Exposure Results and Characterization

O Ps may exhibit a phenomenon known as steady state acetylcholinesterase (AChE) inhibition which is the most sensitive endpoint for all lifestages. After repeated dosing at the same dose, the amount of AChE inhibition in a given dose remains consistent across duration. For this

reason, a s teady

- state point of departure (PoD ) was selected for oral exposure to coumaphos and coumaphoxon (see Table 3 ).

The DEEM acute module was used to conduct partially refined steady state assessments using the steady state endpoint and 21

- day forward rolling water averages. These steady state

assessments estimate 21

- day average daily food and drinking water exposures. The steady state dietary exposure assessments incorporate PDP data, def ault processing factor s
, 100%CT, and a

TAF of 50x for coumaphoxon in drinking water

. The steady state dietary exposure assessment

were conducted for food onl y, drinking water only, and food and drinking. The steady state aggregate dietary exposure estim ates are above HED’s level of concern ( > 100% of the steady state population adjusted dose ( ss PAD ) ) for the U.S. population and all population subgroups

, except adults 50

- 99 years old

. The food only dietary exposure estimate is 2 1 0 % of ssPAD for the U.S. population, and 38 0 % of the ssPAD for children 1

- 2 years old, the most highly exposed population subgroup at the 99.9 th 

### perce ntile

. The drinking water only, dietary exposure estimate

is 3 6 % of the ssPAD for the U.S. population and 1 10 % of th e ssPAD for all infants (<1 year old) , the most highly

- exposed population subgroup, at the 99.9 th 

### percentile. Combined dietary exposure from fo od and drinking water is 2 1 0 % of the ss PAD for the U.S. population and 390 %

of the ssPAD for children 1

- 2 years, the most highly exposed population subgroup. Beef meat is the risk driver when combining food in the steady state assessment for coumaphos, accounting for approximately 9 0% of estimated exposure in the acute assessment based upon critical exposure contribu tion analysis.

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Coumaphos is classified as “ no evidence” of carcinogenicity for humans. Therefore, a cancer dietary exposure analysis is not required.

I. Introduction

Diet ary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute

and two

- day average assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the maximum dose at which HED has concluded that there i s a reasonable expectation

of no adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and steady state assessments , HED is concerned when estimated dietary risk exceeds

100% of the PAD. References that discuss dietary risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessin g Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link:

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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Page 4 of 27 

### http://www.regulations.gov/#!documentDetail;D=EPA

- HQ

- OPP

- 2007

- 0780

- 0001 ; or see SOP 99.6 (20

- AUG

- 1999).

The steady state assessments were conducted in the DEEM acute module using the ste ady

- state endpoint and 21

- day forward

- rolling water averages to provide an estimate of 21

- day (“steady

state”) average daily exposures. These steady state assessments were completed for drinking water alone, food alone, and food + drinking water. For dri nking water alone, the two

- day average assessments, using a 21

- day forward

- rolling average water file, provide an accurate

overall estimate of the 21

- day (“steady

- state”) average daily exposures at the per

- capita 95 th 

### or 99.9 th 

### percentile for drinking wate r, to the extent that predicted drinking water concentrations for any 21

- day duration is known for any given year. For food alone, the two

- day average

assessments reflect an average daily expos ure for a two

- day exposure duration rather than a 21

- day expos ure duration. S ince the DEEM two

- day average assessment does not capture day

- to

d ay variation in food residues, it will generally result in higher food

- only exposure estimates

than a model that calculates 21

- day rolling averages for food. Although the DE EM two

- day

average assessments may result in higher exposure estimates for food , the assessments provide an acceptable estimate of 21

- day (“steady

- state”) average daily exposure for food + drinking

water for use in risk assessment.

The most recent dieta ry risk assessment for coumaphos was conducted by S. Piper ( 01/22 /20 07

, D 3 35163 ).

II. Residue Information

Coumaphos ( O

- [3

- chloro

- 4

- methyl

- 2

- oxo

- 2 H

- 1

- benzopyran

- 7

- yl] O,O

- diethyl phosphorothioate )

is an organophosphate insecticide/a c ar icide currently used for the control of mites and insects on livestock. Permanent tolerances are established for the residues of coumaphos and its oxygen analog (coumapho xon ) at 1.0 ppm in fat, meat, and meat byproducts of cattle, goats, hogs, horses, and shee p, at 0.5 ppm in m ilk fat , at 0.15 ppm in honey, and at 45 ppm in honeycomb (40CFR §180.189[a]). Poultry uses are no longer registered; therefore, tolerances on poultry tissues and eggs were revoked.

Accumulation of coumaphos residues in honey and beeswax following treatment of hives with coumaphos

- impregnated strips were shown to be considerably higher in beeswax than in honey. Field trial data looked for the combined residue of parent and coumaphoxo n in honey/beeswax

and found no detectable resides of coumaphoxon. Magnitude of residue studies reflecting the current types of registered external uses (dusts, sprays, dips, pour

- ons, backrubbers, and bedding treatments) and feeding studies were reviewed

. Based on the ruminant metabolism study, coumaphos was the major residue accounting for 70

- 96% of the residue in tissues and its metabolite, coumaphoxon was not detected in the muscle or fat. Feeding study looked for the combined residue of parent and coumaphoxon in livestock and found detectable resides livestock

tissues (primarily fat samples). However, PDP monitoring data for honey and livestock commodities looked for the parent separately from the oxon and found detectable parent residues, but no c oumaphoxon

. Therefore, coumaphoxon is not expected to be found in food and a TAF of 50x was not used for food and was only applied to drinking water.

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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### Residue Data used for Acute and Steady State Dietary Assessments

A partially refined acute dietary expos ure assessment was conducted using PDP m onitoring data for honey, beef, pork, and milk. Coumaphos and coumapho xon were not detected in any

livestock samples , but coumaphos were detected in honey. An anticipated residue value of 1⁄2 the

combined LOD s (limit of detection) for coumaphos and coumaphoxon were used for the acute

and two

- day average dietary analyses and assumed 100% crop treated

. A default processing

factor for dried beef of 1.92 was also used. See Table 1 below for a summary of the resid ue input values used

.

USDA PDP: Beef adipose, beef liver

, and beef muscle samples were analyzed in 2002. Each sample showed no detects. The LOD s for each coumaphos tissue are 0.003 ppm (1/2 LOD= 0.0015 ppm) and 0.012 ppm (1/2 LOD= 0.006 ppm) for coumaph oxon. A value of 0. 0075 ppm was used for each tissue.

Pork adipose and pork muscle samples were analyzed in 2005. Each sample showed no detects. For pork adipose, the LOD is 0.0012 ppm (1/2 LOD= 0.0006 ppm) for coumaphos and 0.0042

ppm (1/2 LOD= 0.0 02 1 ppm) for coumaphoxon. A value of 0. 0027 ppm used for pork adipose

.

For pork muscle, the LOD is 0.0006 ppm (1/2 LOD= 0.0003 ppm) for coumaphos and 0.004 2 ppm (1/2 LOD= 0.00 2 1 ppm) for coumaphoxon. A value of 0.0024 ppm was used for pork

muscle.

Milk was analyzed in 2004, 2005

, and 2011. Each sample showed no detects. The 2004 and

2005 samples had the same LOD of 0.00011 ppm (1/2 LOD= 0.0 00 06 ppm) for coumaphos and 0.0004 ppm (1/2 LOD= 0.0 002 ppm) for coumaphoxon. In 2011, the LOD is 0.006 ppm ( 1/2 LOD= 0.003 ppm) for coumaphos and 0.0075 ppm (1/2 LOD= 0.00375 ppm) for coumaphoxon.

A value of 0. 00 7 was used for milk.

Honey was analyzed in 2007 and 2008 and there were 263 detectable residues of coumaphos in the 744 samples. No detectable residu e were found of coumaphoxon

. The 2007and 2008 samples had the same LOD of 0.001 ppm (1/2 LOD= 0.0005 ppm) for coumaphos and 0.005 ppm (1/2 LOD= 0.0025 ppm) for coumaphoxon. ( See attachment 9 for residue distribution file )

.

Residues in Fish

PDP monitored pesticide residues in catfish in 2008, 2009, and 2010 and in salmon in 2013. In general, pesticide residues would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic use. To determine whether or not res idues are present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide’s uses and physicochemical properties

. In 2008, 2009, and 2010, PDP analyzed 1479 samples of catfish for coumaphos residues and 2 samples contained detecta ble residues (2008: 0.004; 0.0014 ppm). However, PDP did not analyzed for coumaphoxon during 2008

- 2010 years. In 2013, PDP analyzed for coumaphos (352 samples) and comaphoxon (294 samples) in salmon and found no detectable residues. For this dietary asse ssment, residues in fish were not included in the

assessment.

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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### Table 1. Summary of Data and Residue Estimates Used for Acute and Steady State Dietary Exposure Analysi s for Coumaphos

RAC 1 , 2 Data

Source No. of

Samples No. of

Detectable

Residues

(range of

detectable residues) %CT Processing

Factors Anticipated Residue

Estimates/Tolerance

Ave. Max. Acute /Steady State (AR, RDF) ppm

Honey 2007

- 08 PDP 744 263

(0.001

- 0.0118) 100 100

-- RDF #1

(see Attachment 9 )

Beef (adipose

fat) 2002 PDP 301 0 100 100 0.0075

Beef (liver) 2002 PDP 313 0 100 100 0.0075

Beef (muscle) 2002 PDP 310 0 100 100 1.92 meat

dried meat 0. 0075

Pork (adipose ) 2005 PDP 352 0 100 100

-- 0. 0027

Pork (muscle) 2005 PDP 352 0 100 100

-- 0.0 024

Milk 2011, 2005,

2004 PDP 2228 0 100 100

- 0. 00 7

1. Beef was translated for goat, sheep , rabbit, horse, and hog

. 2. The highest anticipated residue value was used for meat byproducts.



### I I I. Percent Crop Treated Information

The Biological and Economic Analysis Division (BEAD) did not provided an updated Screening Level Usage Analysis (SLUA) for coumaphos in/on honey and livestock. Therefore, the acute and steady state aggregate dietary analyses were performed assuming 100% of each commodity was treated with coumaphos.

IV. Drinking Wa ter Data

References: Addendum to Revised Drinking Water Assessment for the Registration Review of Coumaphos , D 420394

, Faruque Khan

, 0 6 / 02 /2014

.

The estimated drinking water concentration (EDWCs) of coumaphos and coumaphoxon were generated using Tier II Pesticide Root Zone Model/Exposure Analysis Modeling System ( PRZM/EXAMS ) model for surface water and Tier I SCIGROW ( Screening Concentration in Ground Water Program). Pesticide Root Zone Model

- Ground Water model ( PRZM

- GW ) was

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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Page 7 of 27 

### also used for ground water. The current drinking water assessment amends the previous assessment to apply wash

- off fractions for a 24

- hour time instead of half

- hour drying time for two coumaphos formulations (Co

- Ral® flowable concentrate [EPA Reg. No. 11556

- 98] and Co

Ral® emulsifiab le powder/concentrate [EPA Reg. No.11556

- 23]) because they represent a reasonable time frame after application for treated cattle to be caught in a rainstorm.

The drinking water assessment assumed that d uring a rain event, coumaphos wash

- off from

treated cattle can be potentially adsorbed into manure as well as transported as effluent from concentrated animal feeding operations and pasture/rangeland. The EDWCs from runoff and

wash

- off were calculated using the maximum annual application rate ( i.e. , spray: 3 applications @ 0.021 lb a.i./animal = 0.063 lb a.i./animal/y ea r) for cattle as well as data from acceptable registrant

- submitted studies quantifying the fraction of coumaphos that becomes available for exposure after soaking a cow hide in water. U se of this product is restricted to employees of the

USDA

- APHIS 2 

### who are enrolled in the USDA

- APHIS cholinesterase monitoring program 

### . The USDA’s Cattle Fever Tick Eradication Program (CFTEP) uses this product solely in Texas. As a
result, t he 2% wash

- off fra ction after 24 hours dip

- vat treatment in the leaching study was used

.

The residues of concern for drinking water are coumaphos and its o xygen analog coumaphoxon

. A maximum conversion efficiency of coumaphos to coumaphoxon of 10.2% was derived from

availa ble data on photodegradation in water. This conversion efficiency was used to estimate a coumaphoxon application rate of 0.0285 lbs ai/A for drinking water modeling. The EDWCs of coumaphos and coumaphoxon were generated using Tier II PRZM/EXAMS model for surface

water and the Tier I SCIGROW Pesticide Root Zone Model

- Ground Water model was also used for ground water

.

For acute and steady state assessments, the entire 30

- year distribution of estimated daily concentrations was incorporated into the concentrations was incorporated into the

PRZM/EXAMS and used in the probabilistic analyses. For steady state, the TX scenario daily time series was also recalculated using th e 21

- day forward rolling averages. In the 21

- day rolling average distributions, the first data point is the average of days 1

- 21, the second data point is the average of days 2

- 22, the third data point is the average of days 3

- 23, etc. Also, the

time ser ies data were adjusted to reflect 100% conversion of coumaphos to coumaphoxon by multiplying the residues by 50x (see calculation in Attachment 8 ).

Both the acute and steady state dietary assessments, the water residues distribution were incorporated in t he DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” The recommended EDWCs for surface water and groundwater are listed

in Table 2

. The model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.

2 APHIS

- Animal and Plant Health Inspection Service

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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### Table 2

. Maximum EDWCs for Drinking Water Sources for Coumaphos and Coumaphoxon Source of Drinking

Water Estimated Drinking Water concentration (μg/L)

Acute Chronic Average

chronic
Coumaphos

Surface Water 1 

### 0.10 0.05 0.03

Groundwater 2 

### 1.91 x 10

- 03 

### 1.91 x 10

- 03 

### 1.91 x 10

- 03


### Coumaphoxon

Surface Water 0.002 

### 0.0001 6.89 x 10

- 05



### Groundwater ,2 

### 5.06 x 10

- 06 

### 5.06 x 10

- 06 

### 5.06 x 10

- 06



### Coumaphos Equivalents (Coumaphos+Coumaphoxon) 3



### Surface Water 0.102 0.05 0.03

Groundwater 1.9 2 x 10

- 03 

### 1.9 2 x 10

- 03 

### 1.9 2 x 10

- 03

1 EDWCs based on PRZM/EXAMS model

2 EDWCs derived from SCIGROW

3 Coumaphos + Coumaphoxon

- sum of surface water/and or groundwater for coumaphos and coumaphoxon, respectively



### V. DEEM

- FCID Program and Consumption Information

Coumaphos acute and steady state dietary exposure assessments were conducted using the

DEEM

- FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files

develo ped jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups . However , for acute

exposure assessment

, consumption data are retained as individual consumptio n events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. populat ion, all infants (<1 year old), children

1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- indivi dual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with resid ue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those w ho reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for a nalyses performed at all levels of refinement . However, for

deterministic assessments , any sign ificant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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### For steady state assessment, two

- day average food consumption s are calculated on an individual

by

- individual basis. The reported co nsumption amounts of each food item for each day are added together and then divided by two days. For example, if an individual reports eating 100 grams of apple on the first day and 0 grams of apple on the second day, the two

- day average consumption amou nt would be 50 grams/day of apple [(100 grams + 0 grams)/2 days = 50 grams/day]. The resulting two

- day average consumption amount can then be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V I I. Toxicological Information

Coumaphos is a member of the OP class of pesticides. Like other OPs, the initiating event in the adverse outcome pathway (AOP), also often called the mode of action (MOA), for coumaphos involves inhibition of the enzyme acetylcholinesterase (AChE) via pho sphorylation of the serine residue at the active site of the enzyme. EPA plans to move forward with the coumaphos human health risk assessment without toxicity data for the coumaphos oxon degradate. In lieu of coumaphos

- specific oxon CCA data, EPA will u se an oxon toxicity adjustment factor (TAF) of

50x in its calculations. This value considers the data derived from relative potency factors that EPA has identified among oxon metabolites for other organophosphates, with an additional margin of safety incl uded due to the uncertainty in extrapolating oxon potency data across

chemicals.

HED’s ToxSAC met (07/18/2013) to consider the endpoints of toxicological concern for the dietary exposure

. The FQPA 10X Safety Factor will be retained for infants, children, youths, and women of childbearing age for all exposure scenarios. The refore, the results for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,

females 13

- 49, and adults 20

- 49 will in clude an 10x FQPA SF with the exception of adults 50

- 99

years

. Please refer to RA for discussion of 10x SF and TAF of 50x

. T able 3 summarizes the acute (single day) and steady state durations that are appropriate for human health risk

assessment.

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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Page 10 of 27 

### Table 3. Summary of Toxicological Doses and Endpoints and Points of Departure for Coumaphos in Dietary and Non

- Occupational Human Health Risk Assessments a



### Exposure

Scenario Point of

Departure (mg/kg/day) Uncertainty/

FQPA

Factors 5 

### RFD, PAD, & LOC

for Risk

Assessment Study and Toxicological

Effects

Acute Dietary

(All Populations Except

Adults 50

- 99 Years) BMDL 10 = 0.19

mg/kg/day UF A = 10x

UF H = 10x FQPA SF = 10x Acute RfD = 0.0019

mg/kg

aPAD = 0.00019 mg/kg CCA Study (MRID 46258301) in the rat

BMD10 = 0.31 mg/kg (adult males) for

inhibition of RBC AChE in adult male

rats.

Acute Dietary

(Adults 50

- 99 Years) BMDL 10 = 0.19

mg/kg/day UF A = 10x

UF H = 10x FQPA SF = 1x Acute RfD = 0.0019

mg/kg

aPAD = 0.0019 mg/kg CCA Study (MRID 46258301) in the rat

BMD10 = 0.31 mg/kg (adult males) for

inhibition of RBC AChE in adult male

rats. Steady

- State Dietary

(All Populations Except

Adults 50

- 99 Years) BMDL 10 = 0.04

mg/kg/day UF A = 10x

UF H = 10x FQPA SF = 10x ssRfD = 0.0004 mg/kg

ssPAD = 0.00004 mg/kg/day 2 generation reproductive study (MRID 43061701)

BMD10 = 0.05 mg/kg/day for Inhibition of RBC AChE in in F0 and F1 young adults at 90 days in both males and

females

Steady

- State Dietary

(Adults 50

- 99 Years) BMDL 10 = 0.04

mg/kg/day UF A = 10x

UF H = 10x FQPA SF = 1x ssRfD = 0.0004 mg/kg

ssPAD = 0.0004 mg/kg/day 2 generation reproductive study (MRID 43061701)

BMD10 = 0.05 mg/kg/day for Inhibition of RBC AChE in in F0 and F1 young adults at 90 days in both males and

females

Cancer (oral, dermal, inhalation) Classification: not likely to be carcinogenic in humans

Point of Departure (PoD) = A data point or an estimated point that is derived from observed dose

- response data

and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant
human exposures. 

### BMDL 10 = lower confidence interval on the benchmark dose for 10% response. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity
among members of the human population (intraspecies). 

### UF DB = database uncertainty factor. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, ss = steady state or maximal AChE inhibition which

occurs around 2

- 3 weeks for OPs and is a specific exposure assessment conducted for OPs instead of t he traditional short, intermediate, or chronic assessments. The SS assessment is protective of longer durations of exposure, including chronic ). RfD = reference dose. MOE = margin of exposure. LOC = level of concern. N/A = not applicable.



### VI I I. Res ults/Discussion

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 11 of 27 

### As stated above, for acute and steady state assessments, HED is concerned when dietary risk

exceeds 100% of the PAD. The DEEM

- FCID analys e s estimate the dietary exposure of the U.S. population and various population subgroups. The resul ts reported in T able s 4

- 9 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

The results from the 2% wash

- off fraction after 24 hours dip

- vat treatment dietary assessment are shown below for acute and steady state dietary assessments. The acute aggregate dietary ( food only, drinking water only, and food plus drinking water) exposu re estimates are below HED’s

level of concern ( < 100 % of the aPAD) for the U.S. population and all population subgroups.

The food only dietary exposure estimate is 50 % of the acute population adjusted dose (aPAD) for the U.S. population, and 98% of the aP AD for children 3

- 5 years old, the most highly exposed population subgroup at the 99.9 th 

### percentile. The drinking water only, dietary exposure

estimate is 7 % of the aPAD for the U.S. population, and 2 0 % of the aPAD for all infants (<1 years old), the most highly

- exposed population subgroup, at the 99.9 th 

### percentile. Combined dietary exposure from food and drinking water at the 99.9 th 

### percentile of exposure is 51 % of the aPAD for the U.S. population and 99% of the aPAD for children 3

- 5 years, the most high ly exposed population subgroup.

Table 4 . Summary of Acute Dietary (Food Only) Exposure and Risk for Coumaphos

Population Subgroup aPAD (mkd) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile

Exposure (mkd) %

aPAD Exposure

(mkd) %

aPAD Exposure

(mkd) %

aPAD General U.S. Population 0.00019 0.000029 16 0.000051 27 0.000096 50 All Infants (<1 year old) 0.00019 0.000034 18 0.000068 36 0.000158 83

Children 1

- 2 years old 0.00019 0.000061 32 0.000100 52 0.000168 88

Children 3

- 5 years old 0.00019 0.000054 29 0.000095 50 0.000187 98

Children 6

- 12 years old 0.00019 0.000039 21 0.000064 34 0.000106 56

Youth 13

- 19 years old 0.00019 0.000028 15 0.000045 24 0.000082 43

Adults 20

- 49 years old 0.00019 0.000026 13 0.000041 21 0.000066 34

Adults 50

- 99 years old 0.0019 0.000020 1.0 0.000033 1.8 0.000051 2.7

Females 13

- 49 years old 0.00019 0.000022 11 0.000036 19 0.000060 32 mkd = mg/kg/day. aPAD= acute population adjusted dose; Highest exposure at the 99.9 th percentile is in bold font.



### Table 5. Summary of Acute Dietary (Drinking Water Only) Exposure and Risk for Coumaphos

Population Subgroup aPAD (mkd) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile Exposure (mkd) %

aPAD Exposure

(mkd) %

aPAD Exposure

(mkd) %

aPAD

General U.S. Population 0.00019 0.000002 1.2 0.00004 2.3 0.000014 7.3 All Infants (<1 year old) 0.00019 0.000007 3.6 0.000011 6.1 0.000037 20

Children 1

- 2 years old 0.00019 0.000003 1.8 0.000006 3.4 0.000020 11

Children 3

- 5 years old 0.00019 0.000003 1.5 0.000005 2.6 0.000018 9.5

Children 6

- 12 years old 0.00019 0.000002 1.1 0.000004 2.1 0.000012 6.5

Youth 13

- 19 years old 0.00019 0.000002 <1 0.000003 1.8 0.000010 5.2

Adults 20

- 49 years old 0.00019 0.000002 1.2 0.000004 2.0 0.000013 7.0

Adults 50

- 99 years old 0.0019 0.000002 <1 0.000004 <1 0.000013 <1

Females 13

- 49 years old 0.00019 0.000002 1.2 0.000004 2.1 0.000013 7.0 mkd = mg/kg/day. aPAD= acute population adjusted dose; Highest exposure at the 99.9 th percentile is in bold font.

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 12 of 27 

### Table 6 . Summary of Acute Dietary (Food and TX Drinking Water) Exposure and Risk for Coumaphos

Population Subgroup aPAD (mkd) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile Exposure (mkd) %

aPAD Exposure

(mkd) %

aPAD Exposure

(mkd) %

aPAD

General U.S. Population 0.00019 0.000030 16 0.000052 27 0.000098 51 All Infants (<1 year old) 0.00019 0.000035 19 0.000070 37 0.000161 85

Children 1

- 2 years old 0.00019 0.000062 32 0.000100 53 0.000171 90

Children 3

- 5 years old 0.00019 0.000056 29 0.000096 51 0.000188 99

Children 6

- 12 years old 0.00019 0.000040 21 0.000065 34 0.000107 56

Youth 13

- 19 years old 0.00019 0.000029 15 0.000045 24 0.000083 44

Adults 20

- 49 years old 0.00019 0.000026 14 0.000041 22 0.000067 35

Adults 50

- 99 years old 0.0019 0.000021 1.1 0.000035 1.8 0.000055 2.9

Females 13

- 49 years old 0.00019 0.000023 12 0.000038 20 0.000064 34
mkd = mg/kg/day. aPAD= acute population adjusted dose; Highest exposure at the 99.9 th percentile is in bold font

.



### The steady state aggregate dietary (food alone, water alone and food plus drinking water) exposure estimates are above HED’s level of concern (>100% of the PAD) for the U.S. population and all population subgroups except adults 50

- 99 years. The steady state aggregate dietary exposure estimates are above HED’s level of concern (>100% of the steady state population adjusted dose ( ssPAD)) for the U.S. population and all population subgroups

, except
adults 50

- 99 years old

. The food only dietary exposure estimate is 2 1 0 % of ssPAD for the U.S. population, and 38 0 % of the ssPAD for children 1

- 2 years old, the most highly exposed population subgroup at the 99.9 th 

### percentile. The drinking water only, dietary exposure estimate

is 3 6 % of the ssPAD for the U.S. population and 1 10 % of the ssPAD for all infants (<1 year old), the most highly

- exposed population subgroup, at the 99.9 th 

### percentile. Combined dietary exposure from food and drinking water is 2 1 0 % of the ssPAD for the U.S. population and 390 %

of the ssPAD for children 1

- 2 years, the most highly exposed population subgroup.

Table 7 . Summary of Steady State Dietary (Food Only) Exposure and Risk for Coumaphos

Population Subgroup ssPAD (mkd) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile Exposure (mkd) %

ssPAD Exposure

(mkd) %

ssPAD Exposure

(mkd) %

ssPAD General U.S. Population 0.00004 0.000023 64 0.000037 100 0.000074 210 All Infants (<1 year old) 0.00004 0.000027 76 0.000050 140 0.000117 330

Children 1

- 2 years old 0.00004 0.000044 120 0.000066 180 0.000137 380

Children 3

- 5 years old 0.00004 0.000043 120 0.000073 200 0.000112 310

Children 6

- 12 years old 0.00004 0.000031 87 0.000045 130 0.000097 270

Youth 13

- 19 years old 0.00004 0.000022 62 0.000032 90 0.000054 150

Adults 20

- 49 years old 0.00004 0.000021 57 0.000030 84 0.000049 140

Adults 50

- 99 years old 0.0004 0.000016 4.6 0.000025 6.8 0.000034 9.4

Females 13

- 49 years old 0.00004 0.000018 49 0.000026 72 0.000049 140
mkd = mg/kg/day. ssPAD = steady state population adjusted dose; Highest exposure at the 99.9 th percentile is in bold font

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 13 of 27 

### Table 8 . Summary of Steady State Dietary (Drinking Water Only) Exposure and Risk for Coumaphos

Population Subgroup ssPAD (mkd) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile Exposure (mkd) %

ssPAD Exposure

(mkd) %

ssPAD Exposure

(mkd) %

ssPAD General U.S. Population 0.00004 0.000007 5.9 0.00004 11 0.000013 36 All Infants (<1 year old) 0.00004 0.000003 18 0.000011 30 0.000039 110

Children 1

- 2 years old 0.00004 0.000003 8.8 0.000006 16 0.000018 51

Children 3

- 5 years old 0.00004 0.000003 7.1 0.000005 13 0.000015 42

Children 6

- 12 years old 0.00004 0.000002 5.3 0.000003 9.7 0.000011 31

Youth 13

- 19 years old 0.00004 0.000002 4.7 0.000003 8.2 0.000009 26

Adults 20

- 49 years old 0.00004 0.000002 5.7 0.000004 9.9 0.000013 35

Adults 50

- 99 years old 0.0004 0.000002 <1 0.000003 <1 0.000012 3.4

Females 13

- 49 years old 0.00004 0.000002 5.9 0.000004 9.8 0.000013 35
mkd = mg/kg/day. ssPAD = steady state population adjusted dose; Highest exposure at the 99.9 th percentile is in bold font



### Table 9 . Summary of Steady State Dietary (Food and TX Drinking Water) Exposure and Risk for Coumaphos

Population Subgroup ssPAD (mkd) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile Exposure (mkd) %

ssPAD Exposure

(mkd) %

ssPAD Exposure

(mkd) %

ssPAD General U.S. Population 0.00004 0.000024 67 0.000039 110 0.000075 210 All Infants (<1 year old) 0.00004 0.000029 81 0.000056 150 0.000123 340

Children 1

- 2 years old 0.00004 0.000046 130 0.000067 190 0.000140 390

Children 3

- 5 years old 0.00004 0.000044 120 0.000074 210 0.000114 320

Children 6

- 12 years old 0.00004 0.000032 89 0.000046 130 0.000098 270

Youth 13

- 19 years old 0.00004 0.000023 64 0.000033 91 0.000055 150

Adults 20

- 49 years old 0.00004 0.000021 59 0.000031 87 0.000051 140

Adults 50

- 99 years old 0.0004 0.000017 4.8 0.000026 7.1 0.000036 10

Females 13

- 49 years old 0.00004 0.000018 51 0.000028 77 0.000051 140
mkd = mg/kg/day. ssPAD = steady state population adjusted dose; Highest exposure at the 99.9 th percentile is in bold font



### IX. Inputs/Outputs

HED has conducted partially refined acute and steady state dietary risk assessments for coumaphos. The assumption with respect to food made in this acute and steady state dietary

assessment are conservative due to the following: 100% crop treated was assumed for all commodities; the FQPA 10X Safety Factor will be retained for infants, children, youths, and women of childbearing age for all exposure scenarios ; and i n lieu of coumaphos

- specific oxon CCA data, an oxon TAF of 50x was used. Beef meat cooked is the risk driver when combining

food and drinking water for the acute and/or steady state assessment s ba sed upon critical exposure contribution (CEC) analys e s. These factors resulted in the steady state aggregate dietary exposure estimates to be above HED ’s level of concern for the general U.S. population and all population subgroups.

X. Conclusions

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 14 of 27 

### The acute aggregate dietary exposure estimates for food and drinking water were below HED’s level of concern for the general U.S. population and all population subgroups; however, the steady state aggregate dietary exposure estimates for food and drinking water were above HED ’s

level of concern for the general U.S. population and all population subgroups. For steady state,

the c ombined dietary exposure from food and drinking water is 40 0 % of the ssPAD for children

3

- 5 years old

, the most highly exposed po pulation subgroup

.

XI. List of Attachments

Attachment 1: Acute (Food Only ) Residue Input File Attachment 2: Acute (Food Alone) Results File

Attachment 3 : Acute (M02

- Water Alone) Results File

Attachment 4 : Acute (Food + TXM02 Drinking Water

- PR ZM

- EXAM ) Results File Attachment 5: Acute (Food + TXM02 Drinking Water

- PR ZM

- EXAM ) CEC Analysis Attachment 6: Steady State (Food Only) Residue Input File

Attachment 7 : Steady State (Food Alone) Res ult File

Attachment 8 : Steady State Drinking Water TX_ M02

- Water Alone Input and Results File

Attachment 9 : Steady State (Food + TX

_ M02 Drinking Water

- PR ZM

- EXAM ) Results File Attachment 10: Steady State (Food + TX_M02 Drinking Water

- PR ZM

- EXAM ) CEC Analysis

Attachment 11 : Excerpt for the Drinking Water Calculation for 50x TAF for the Oxon

Attachment 12 : Residue Distribution File (RDF) for Honey

Attachment 1: Acute and Steady State (Food Only ) Residue Input File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID Acute analysis for COUMAPHOS

Residue file name:

C: \ Users \ spiper \ Documents \ DEEM_version316 \ Coumaphos \ Coumaphosfoodonly_acute.r08 Analysis Date 02

- 02

- 2016 Residue file dated: 02

- 02

- 2016/15:54:03 Reference dose: aRfD = 0.00019 mg/kg bw/day NOEL = 0.19 mg/kg bw/day
Comment: Food Only

---------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis:
Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

----- ---- ----------- - ----------- ----------- ---------- 1 6 Honeyrdf.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 3100044000 31 Beef, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100044001 31 Beef, meat

- babyfood 0.007500 1.000 1 .000 PDP da

Full comment: PDP data
3100045000 31 Beef, meat, dried 0.007500 1.920 1.000 PDP da

Full comment: PDP data 3100046000 31 Beef, meat byproducts 0.007500 1.000 1.000 PDP da

Full co mment: PDP data 3100046001 31 Beef, meat byproducts

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100047000 31 Beef, fat 0.007500 1.000 1.000 PDP da

Full comment: PDP data

3100047001 3 1 Beef, fat

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3100048000 31 Beef, kidney 0.007500 1.000 1.000 PDP da

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 15 of 27 Full comment: PDP data
3100049000 31 Beef, liver 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100049001 31 Beef, liver

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3200169000 32 Goat, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3200170000 32 Goat, meat byproducts 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3200171000 32 Goat, fat 0.007 500 1.000 1.000 PDP da

Full comment: PDP data 3200172000 32 Goat, kidney 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3200173000 32 Goat, liver 0.007500 1.000 1.000 PDP da

Full comment: PDP data 9500186000 O Honey 1.000000 1.000 1.000 1 PDP da

Full comment: PDP data 9500186001 O Honey

- babyfood 1.000000 1.000 1.000 1 PDP da

Full comment: PDP dat a 3300189000 33 Horse, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3600222000 36 Milk, fat 0.007000 1.000 1.000 PDP da

Full comment: PDP data
3600222001 36 Milk, fat

- baby food/infant formu 0.007000 1.000 1.000 PDP da

Full comment: PDP data
3400290000 34 Pork, meat 0.002400 1.000 1.000 PDP da

Full comment: PDP data
3400290001 34 Pork, meat

- babyfood 0.002400 1.000 1.000 PDP da

Full comment: PDP data
3400291000 34 Pork, skin 0.002700 1.000 1.000 PDP da

Full comment: PDP data 3400292000 34 Pork, meat byproducts 0.002700 1 .000 1.000 PDP da

Full comment: PDP data 3400292001 34 Pork, meat byproducts

- babyfood 0.002700 1.000 1.000 PDP da

Full comment: PDP data
3400293000 34 Pork, fat 0.002700 1.000 1.000 PDP da

Full comment: PDP data
3400293001 34 Pork, fat

- babyfood 0.002700 1.000 1.000 PDP da

Full comment: PDP data 3400294000 34 Pork, kidney 0.002700 1.000 1.000 PDP da

Full comment: PDP data

34002 95000 34 Pork, liver 0.002700 1.000 1.000 PDP da

Full comment: PDP data 3500339000 35 Sheep, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500339001 35 Sheep, meat

- babyf ood 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500340000 35 Sheep, meat byproducts 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500341000 35 Sheep, fat 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500341001 35 Sheep, fat

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500342000 35 Sheep, kidney 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500343000 35 Sheep, liver 0.007500 1.000 1.000 PDP da

Full comment: PDP data



### Attachmen t 2: Acute ( Food Alone) Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for COUMAPHOS NHANES 2003

- 2008 2

- Day Residue file: Coumaphosfoodonly_acute.r08 Adjustment factor #2 used. Analysis Date: 02

- 02

- 2016/15:59:20 Residue file dated: 02

- 02

- 2016/15:54:03

NOEL (Ac ute) = 0.190000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 16 of 27 MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB
Run Comment: "Food Only"

===============================================================================

Summar y calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---- ------ ------- -------- Total US Population:

0.000029 15.52 6444 0.000051 26.76 3736 0.000096 50.33 1987

All Infants:

0.000034 17.71 5645 0.000068 35.76 2796 0.000158 83.35 1199

Children 1

- 2:

0.000061 31.90 3134 0.000100 52.44 1906 0.000168 88.19 1133

Children 3

- 5:

0.000054 28.67 3488 0.000095 49.83 2006 0.000187 98.42 1016

Children 6

- 12:

0.000039 20.74 4822 0.000064 33.51 2984 0.000106 55.93 1788

Youth 13

- 19:

0.000028 14.87 6725 0.000045 23.52 4251 0.000082 43.03 2324

Adults 20

- 49:

0.000026 13.49 7411 0.000041 21.32 4690 0 .000066 34.49 2899

Adults 50

- 99:

0.000020 10.47 9554 0.000033 17.54 5700 0.000051 26.69 3746

Female 13

- 49:

0.000022 11.43 8752 0.000036 19.20 5208 0.000060 31.70 3154



### Attachment 3 : Acute ( M 02

- Water Alone) Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID Acute analysis for COUMAPHOS

Residue file name:

C: \ Users \ spiper \ Documents \ DEEM_version316 \ Coumaphos \ Coumaphos_DWonly_TAF50x_acute.r08 Analysis Date 02

- 29

- 2016 Residue file dated: 02

- 29

- 2016/11:39:21 Reference dose: aRfD = 0.00019 mg/kg bw/day NOEL = 0.19 mg/kg bw/day
Comment: Food Only

---------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis:
Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

----- ---- ------------ ----------- ----------- ---------- 1 6 TXM02_DW_TAF50_MW.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 8601000000 86A Water, direct, all so urces 1.000000 1.000 1.000 1 TX M02
8602000000 86B Water, indirect, all sources 1.000000 1.000 1.000 1 TX M02

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for COUMAPHOS NHANES 2003

- 2008 2

- Day Residue file: Coumaphos_DWonly_TAF50x_acute.r08 Adjustment factor #2 used. Analysis Date: 02

- 29

- 2016/11:45:34 Residue file dated: 02

- 29

- 2016/11:39:21 NOEL (Acute) = 0.190000 mg/kg body

- wt/day

Acute Pop A djusted Dose (aPAD) varies with population; see individual reports
RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB
Run Comment: "Food Only"

======================================================== =======================

Summary calculations

-- per capita:

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 17 of 27 --- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aPAD MOE Exposure % aPAD MOE Exposure % aPAD MOE

---------- ------- -------- - --------- ------- -------- ---------- ------- -------- Total US Population:

0.000002 1.25 79988 0.000005 2.40 41716 0.000015 7.83 12763

All Infants:

0.000007 3.80 26313 0.000012 6.40 15631 0.000043 22.48 4448

Children 1

- 2:

0.000004 1.90 52749 0.000007 3.57 27998 0.000022 11.41 8767

Children 3

- 5:

0.000003 1.54 64831 0.000005 2.79 35810 0.000018 9.58 10434

Children 6

- 12:

0.000002 1.16 86366 0.000004 2.18 45778 0.000013 6.79 14725

Youth 13

- 19:

0.000002 1.01 99063 0.000004 1.92 52034 0.000011 5.73 17454

Adults 20

- 49:

0.000002 1.23 81463 0.000004 2.16 46356 0.000014 7.52 13302

Adults 50

- 99:

0.000002 0.11 89477 0.000004 0.20 49975 0.000014 0.73 13662

Female 13

- 49:

0.000002 1.25 80194 0.000004 2.17 46086 0.000015 7.64 13088



### Attachment 4 : Acute (Food + TXM02 Drinking Water

- PR ZM

- EXAM ) Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for COUMAPHOS NHANES 2003

- 2008 2

- Day Residue file: CoumaphosfoodDWM02_acute.r08 Adjustment factor #2 used. Analysis Date: 02

- 29

- 2016/12:09:58 Residue file dated: 02

- 29

- 2016/12:02:31 NOEL (Acute) = 0.190000 mg/kg body

- wt/day
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports
RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB
Run Comment: "Food Only"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99 .9th Percentile

---- Exposure % aPAD MOE Exposure % aPAD MOE Exposure % aPAD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.000030 16.05 6231 0.000052 27.42 3646 0.000098 51.45 1943

All Infants:

0.000035 18.64 5364 0.000070 36.73 2722 0.000162 85.08 1175

Children 1

- 2:

0.000062 32.42 3084 0.000101 52.95 1888 0.000171 90.08 1110

Children 3

- 5:

0.000 056 29.31 3411 0.000096 50.71 1971 0.000189 99.49 1005

Children 6

- 12:

0.000040 21.20 4716 0.000065 34.16 2927 0.000106 55.98 1786

Youth 13

- 19:

0.000029 15.19 6583 0.000045 23.87 4188 0.000083 43.66 2290

Adults 20

- 49:

0.000026 13.90 7192 0.000042 21.84 4578 0.000067 35.21 2839

Adults 50

- 99:

0.000021 1.10 9083 0.000035 1.84 5449 0.000056 2.92 3422

Female 13

- 49:

0.000023 11.93 8384 0.000038 19.99 5002 0.000065 34.39 2907



### Attachment 5: Acute (Food + TXM02 Drinking Water

- PR ZM

- EXAM ) CEC Analysis

US EPA

DEEM

- FCID Acute Critical Exposure Contribution Analysis (Ver. 3.18, 03

- 08

- d)

NHANES 2003

- 2008 2

- Day

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 18 of 27 Residue file =

C: \ Users \ spiper \ Documents \ DEEM_version316 \ Coumaphos \ CoumaphosfoodDWM02_acute.r08 Date and time of analysis: 02

- 29

- 2016 12:14:29 Daily totals for food and foodform consumption used. Adjustment factor #2 used. Minimum exposure contribution = 4%

MC Iterations = 1000 Seed = 10 RNG = MS VB CEC records generated for first 90 iterations. Exposures divided by body weight

Subpopulations: 1 Total US Population

2 Children 1

- 2

3 C hildren 3

- 5

================================================================================ Total US Population Low percentile for CEC records: 99 Exposure (mg/day) = 0.000052 High percentile for CEC records: 99.9 Exposure (mg/day) = 0.000098

Number of actual records in this interval: 61603

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including d uplicates)

Food FF N Percent Food Name

---------- --- ----- ------- ------------- 3100044000 210 32652 21.29% Beef, meat

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 211 16568 14.73% Beef, meat

- Cooked; Fresh or N/S; Baked
3100044000 213 18532 12.93% Beef, meat

- Cooked; Fresh or N/S; Fried
3600222000 110 44764 12.09% Milk, fat

- Uncooked; Fresh or N/S; Cook Meth N/S
3100044000 212 8512 6.36% Beef, meat

- Cooked; Fre sh or N/S; Boiled
3100047000 210 28039 5.75% Beef, fat

- Cooked; Fresh or N/S; Cook Meth N/S
3100047000 213 14912 2.56% Beef, fat

- Cooked; Fresh or N/S; Fried
3100047000 211 13758 1.91% Beef, fat

- Cooked; Fresh or N/S; Baked

31 00046000 210 10321 1.59% Beef, meat byproducts

- Cooked; Fresh or N/S; Cook Meth
Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent o f total exposure for all records (including duplicates)

Food N Percent Food Name

---------- ----- ------- ------------- 3100044000 83289 58.32% Beef, meat
3600222000 64636 14.66% Milk, fat

3100047000 66562 11 .93% Beef, fat
3400290000 11650 1.87% Pork, meat 3100046000 11950 1.84% Beef, meat byproducts

================================================================================ Children 1

- 2 Low percentile for CEC records: 99 Exposu re (mg/day) = 0.000101 High percentile for CEC records: 99.9 Exposure (mg/day) = 0.000171

Number of actual records in this interval: 2376

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name

---------- --- ----- ------- ------------- 3100044000 213 1050 24.66% Beef, meat

- Cooked; Fresh or N/S; Fried
3100044000 210 1023 17.58% Beef, meat

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 211 455 12.62% Beef, meat

- Cooked; Fresh or N/S; Baked

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 19 of 27 3600222000 110 1864 8.23% Milk, fat

- Uncooked; Fresh or N/S; Cook Meth N/S
3100047000 213 958 6.27% Beef, fat

- Cooked; Fresh or N/S; Fried
3100047000 210 753 5.06% Beef, fat

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 240 270 3.12% Beef, m eat

- Cooked; Canned; Cook Meth N/S
3100049000 210 90 2.56% Beef, liver

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 212 120 2.49% Beef, meat

- Cooked; Fresh or N/S; Boiled
3100044000 250 325 2.43% Beef, meat

- Cooked; C ured etc; Cook Meth N/S
Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name

---------- ----- ------- ------------- 3100044000 3243 62.90% Beef, meat
3100047000 2718 15.70% Beef, fat
3600222000 2163 9.02% Milk, fat
3100049000 90 2.56% Beef, liver

31000 46000 601 1.68% Beef, meat byproducts

================================================================================ Children 3

- 5 Low percentile for CEC records: 99 Exposure (mg/day) = 0.000096
High percentile for CEC records: 99.9 Exposure (mg/day) = 0.000189

Number of actual records in this interval: 2283

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposu re for all records (including duplicates)

Food FF N Percent Food Name

---------- --- ----- ------- ------------- 3100044000 210 1188 26.88% Beef, meat

- Cooked; Fresh or N/S; Cook Meth N/S

3100044000 213 82 3 22.60% Beef, meat

- Cooked; Fresh or N/S; Fried
3100044000 211 368 9.18% Beef, meat

- Cooked; Fresh or N/S; Baked
3100047000 210 1093 7.47% Beef, fat

- Cooked; Fresh or N/S; Cook Meth N/S

3100044000 212 269 6.99% Beef , meat

- Cooked; Fresh or N/S; Boiled
3600222000 110 1558 5.81% Milk, fat

- Uncooked; Fresh or N/S; Cook Meth N/S
3100047000 213 815 4.68% Beef, fat

- Cooked; Fresh or N/S; Fried
3200169000 210 90 2.83% Goat, meat

- Cooked; F resh or N/S; Cook Meth N/S
3100046000 210 454 1.56% Beef, meat byproducts

- Cooked; Fresh or N/S; Cook Meth
Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (includ ing duplicates) %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name

---------- ----- ------- ------------- 3100044000 2828 66.27% Beef, meat
3100047000 2450 13.69% Beef, fat
3600222000 1930 7.03% Milk, fat
3200169000 90 2.83% Goat, meat



### Attachment 6: Steady State (Food Only) Residue Input File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID Acute analysis f or COUMAPHOS

Residue file name:

C: \ Users \ spiper \ Documents \ DEEM_version316 \ Coumaphos \ Coumaphosfoodonly_acuteSS.r08 Analysis Date 02

- 04

- 2016 Residue file dated: 02

- 02

- 2016/19:06:21 Reference dose: aRfD = 0.000036 mg/kg bw/day NOEL = 0.036 mg/kg bw/day
Comment: Food Only

- Steady State

---------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis:
Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 20 of 27 --- -- ---- ------------ ----------- ----------- ---------- 1 6 Honeyrdf.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 3100044000 31 Beef, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100044001 31 Beef, meat

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100045000 31 Beef, meat, dried 0.007500 1.920 1.000 PDP da

Full comment: PDP data 3100046000 31 Beef, meat byproducts 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3100046001 31 Beef, meat byproducts

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100047000 31 Beef, fat 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100047001 31 Beef, fat

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3100048000 31 Beef, kidney 0.007500 1.000 1.000 PDP da

Full comment: PDP data

3100049000 31 Bee f, liver 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3100049001 31 Beef, liver

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3200169000 32 Goat, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3200170000 32 Goat, meat byproducts 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3200171000 32 Goat, fat 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3200172000 32 Goat, kidney 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3200173000 32 Goat, liver 0.007500 1.000 1.000 PDP da

Full commen t: PDP data 9500186000 O Honey 1.000000 1.000 1.000 1 PDP da

Full comment: PDP data 9500186001 O Honey

- babyfood 1.000000 1.000 1.000 1 PDP da

Full comment: PDP data

3300189000 33 Horse, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data
3600222000 36 Milk, fat 0.007000 1.000 1.000 PDP da

Full comment: PDP data
3600222001 36 Milk, fat

- baby food/infant f ormu 0.007000 1.000 1.000 PDP da

Full comment: PDP data
3400290000 34 Pork, meat 0.002400 1.000 1.000 PDP da

Full comment: PDP data
3400290001 34 Pork, meat

- babyfood 0.002400 1.000 1.0 00 PDP da

Full comment: PDP data
3400291000 34 Pork, skin 0.002700 1.000 1.000 PDP da

Full comment: PDP data 3400292000 34 Pork, meat byproducts 0.002700 1.000 1.000 PDP da

Full comm ent: PDP data 3400292001 34 Pork, meat byproducts

- babyfood 0.002700 1.000 1.000 PDP da

Full comment: PDP data
3400293000 34 Pork, fat 0.002700 1.000 1.000 PDP da

Full comment: PDP data

3400293001 34 Pork, fat

- babyfood 0.002700 1.000 1.000 PDP da

Full comment: PDP data 3400294000 34 Pork, kidney 0.002700 1.000 1.000 PDP da

Full comment: PDP data
3400295000 34 Pork, liver 0.002700 1.000 1.000 PDP da

Full comment: PDP data 3500339000 35 Sheep, meat 0.007500 1.000 1.000 PDP da

Full comment: PDP data

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 21 of 27 3500339001 35 Sheep, meat

- babyfood 0.007500 1.000 1 .000 PDP da

Full comment: PDP data 3500340000 35 Sheep, meat byproducts 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500341000 35 Sheep, fat 0.007500 1.000 1.000 PDP da

Full co mment: PDP data 3500341001 35 Sheep, fat

- babyfood 0.007500 1.000 1.000 PDP da

Full comment: PDP data 3500342000 35 Sheep, kidney 0.007500 1.000 1.000 PDP da

Full comment: PDP data

3500343000 3 5 Sheep, liver 0.007500 1.000 1.000 PDP da

Full comment: PDP data



### Attachment 7 : Steady State ( Food Alone) Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for COUMAPHOS NHANES 2003

- 2008 2

- Day Residue file: Coumaphosfoodonly_acuteSS.r08 Adjustment factor #2 used. Analysis Date: 02

- 02

- 2016/19:13:50 Residue file dated: 02

- 02

- 2016/19:06:21 NOEL (Acute) = 0.036000 mg/kg b ody

- wt/day
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported RAC/FF intake summed over 24 hours

MC iterations = 2000 ; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: "Food Only

- Steady State"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aPAD MOE Exposure % aPAD MOE Exposure % aPAD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.000026 71.33 1401 0.000041 114.41 874 0.000078 215.83 463

All Infants:

0.000 032 88.66 1127 0.000059 164.38 608 0.000124 345.37 289

Children 1

- 2:

0.000054 148.81 672 0.000071 196.39 509 0.000140 389.27 256

Children 3

- 5:

0.000047 129.32 773 0.000079 219.51 455 0.00011 2 310.22 322

Children 6

- 12:

0.000034 95.34 1048 0.000049 135.07 740 0.000098 273.41 365

Youth 13

- 19:

0.000024 65.91 1517 0.000034 95.06 1052 0.000060 166.23 601

Adults 20

- 49:

0.000022 60.25 16 59 0.000032 88.36 1131 0.000051 142.88 699

Adults 50

- 99:

0.000017 4.30 2091 0.000025 6.35 1416 0.000035 8.69 1035

Female 13

- 49:

0.000018 51.25 1951 0.000028 76.86 1301 0.000051 142.10 703



### Attachment 8 : Steady State Drinking Water TX_ M02 Alone Input and Result File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID Acute analysis for COUMAPHOS

Residue file name:

C: \ Users \ spiper \ Documents \ DEEM_version316 \ Coumaphos \ Coumaphos_DWonly_TAF50x_SS.r08 Analysis Date 12

- 02

- 2015 Residue file dated: 07

- 20

- 2015/13:27:59 Reference dose: aRfD = 0.000036 mg/kg bw/day NOEL = 0.036 mg/kg bw/day
Comment: Steady State

-- -------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis:
Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 22 of 27 ----- ---- ------------ ---------- - ----------- ---------- 1 6 CoumaphosTX_M02_TAF50_SS.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------ ------------------------- ---------- ------ ------ --- ------- 8601000000 86A Water, direct, all sources 1.000000 1.000 1.000 1
8602000000 86B Water, indirect, all sources 1.000000 1.000 1.000 1

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for COUMAPHOS NHANES 2003

- 2008 2

- Day Residue file: Coumaphos_DWonly_TAF50x_SS.r08 Adjustment factor #2 used. Analysis Date: 12

- 02

- 2015/12:36:57 Resid ue file dated: 07

- 20

- 2015/13:27:59 NOEL (Acute) = 0.036000 mg/kg body

- wt/day
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported RAC/FF intake summed over 24 hours

MC iterations = 2000 ; MC list i n residue file; MC seed = 10; RNG = MS VB
Run Comment: "Steady State"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Pe rcentile

---- Exposure % aPAD MOE Exposure % aPAD MOE Exposure % aPAD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.000002 5.85 17090 0.000004 11.02 9072 0.000013 35.64 2805

All Infants:

0.000007 18.21 5492 0.000011 29.74 3361 0.000039 107.09 933

Children 1

- 2:

0.000003 8.83 11321 0.000006 16.18 6180 0.000018 51.37 1946

Children 3

- 5:

0.000003 7.05 14193 0.000005 12.51 7991 0.000015 42.37 2360

Children 6

- 12:

0.000002 5.27 18975 0.000003 9.71 10299 0.000011 31.16 3209

Youth 13

- 19:

0.000002 4.68 21380 0.000003 8.21 12186 0.000009 26.22 3813

Adults 20

- 49:

0.000002 5.74 17432 0.000004 9.86 10142 0.000013 35.07 2851

Adults 50

- 99:

0.000002 0.54 18622 0.000003 0.92 10824 0.000012 3.38 2956

Female 13

- 49:

0.000002 5.86 17075 0.000004 9.80 10206 0.000013 34.87 2868



### Attachment 9 : Steady State (Food + TX

_ M02 Drinking Water

- PR ZM

- EXAM ) Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for COUMAPHOS NHANES 2003

- 2008 2

- Day Residue file: Coumaphos_foodDWM02_TAF50x_acuteSS.r08 Adjustment factor #2 used. Analysis Date: 02

- 02

- 2016/22:00:56 Residue file dated: 02

- 02

- 2016/21:50:01 NOEL (Acute) = 0.036000 mg/kg body

- wt/day
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported RAC/FF intake summed over 24 hours

MC iterations = 2000 ; MC list in residue file; MC seed = 10; RNG = MS VB Run Comment: "Food Only

- Steady State"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percent ile

---- Exposure % aPAD MOE Exposure % aPAD MOE Exposure % aPAD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.000027 73.82 1354 0.000043 118.66 842 0 .000080 221.32 451

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 23 of 27 All Infants:

0.000033 93.02 1075 0.000066 182.18 548 0.000130 362.40 275

Children 1

- 2:

0.000055 152.02 657 0.000074 206.19 484 0.000144 400.12 249

Children 3

- 5:

0.000048 132.83 752 0.000081 223.68 447 0.000114 315.73 316

Children 6

- 12:

0.000035 98.28 1017 0.000049 136.77 731 0.000099 273.90 365

Youth 13

- 19:

0.000024 67.88 1473 0.000035 97.41 1026 0.000060 167.52 596

Adults 20

- 49:

0.000023 62.99 1587 0.000033 91.07 1098 0.000053 147.11 679

Adults 50

- 99:

0.000018 4.59 1959 0.000027 6.68 1347 0.000037 9.31 966

Female 13

- 49:

0.000019 53.71 1861 0.000029 81.19 1231 0.000053 146.39 683



### Attachment 10 : Steady State (Food + TXM02 Drinking Water

- PR ZM

- EXAM ) CEC Analysis

US EPA

DEEM

- FCID Acute Critical Exposure Contribution Analysis (Ver. 3.18, 03

- 08

- d)

NHA NES 2003

- 2008 2

- Day

Residue file =

C: \ Users \ spiper \ Documents \ DEEM_version316 \ Coumaphos \ Coumaphos_foodonly_TAF50x_acuteSS.r08 Date and time of analysis: 02

- 04

- 2016 10:06:39 Daily totals for food and foodform consumption used. Adjustment factor #2 used. Minimum exposure contribution = 4%

MC Iterations = 1000 Seed = 10 RNG = MS VB CEC records generated for first 90 iterations. Exposures divided by body weight

Subpopulations: 1 Total US Population

2 Children 1

- 2

3 Children 3

- 5

============== ================================================================== Total US Population Low percentile for CEC records: 99 Exposure (mg/day) = 0.001176 High percentile for CEC records: 99.9 Exposure (mg/day) = 0.002265

Number of actual records in this interval: 60480

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name

---------- --- ----- ------- ------------- 3100044000 210 35100 24.99% Beef, meat

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 211 16920 16.07% Beef, meat

- Cooked; Fresh or N/S; Baked

31000 44000 213 17730 13.62% Beef, meat

- Cooked; Fresh or N/S; Fried
3100047000 210 33390 11.72% Beef, fat

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 212 8010 6.92% Beef, meat

- Cooked; Fresh or N/S; Boiled

3600222000 110 32760 5.96% Milk, fat

- Uncooked; Fresh or N/S; Cook Meth N/S
3100047000 213 15210 2.73% Beef, fat

- Cooked; Fresh or N/S; Fried
3100047000 211 13680 2.08% Beef, fat

- Cooked; Fresh or N/S; Baked

Critical foods (without foodforms) fo r this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 24 of 27 ---------- ----- ----- -- ------------- 3100044000 84330 64.66% Beef, meat
3100047000 72540 18.35% Beef, fat
3600222000 42390 6.99% Milk, fat 3100046000 13950 2.21% Beef, meat byproducts
3100044001 1080 1.29% Beef, meat

- babyfood

3100 045000 990 0.80% Beef, meat, dried 3500339000 630 0.48% Sheep, meat
3400293000 2880 0.29% Pork, fat 3800221000 450 0.22% Meat, game
3200169000 180 0.21% Goat, meat
3100049000 180 0.12% Beef, liver 3500341000 540 0.11% Sheep, fat
3100047001 630 0.07% Beef, fat

- babyfood
3400291000 90 0.01% Pork, skin

================================================================================ Children 1

- 2 Low percentile for CEC records: 99 Exposure (mg/day) = 0.002393 High percentile for CEC records: 99.9 Exposure (mg/day) = 0.003949

Number of actual records in this interval: 2250

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name

---------- --- ----- ------- ------------- 3100044000 213 900 24.80% Beef, meat

- Cooked; Fresh or N/S; Fried
3100044000 210 1170 22.01% Beef, meat

- Cooked; Fresh or N/S; Cook Meth N/S
3100047000 210 1170 12.54% Beef, fat

- Cooked; Fresh or N/S; Cook Meth N/S

3100044000 211 360 11.28% Beef, meat

- Cooked; Fresh or N/S; Baked
3100047000 213 900 6.44% Beef, fat

- Cooked; Fresh or N/S; Fried
3600222000 110 900 3.26% Milk, fat

- Uncooked; Fresh or N/S; Cook Meth N/S
3100049000 210 90 2.80% Beef, liver

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 250 270 2.05% Beef, meat

- Cooked; Cured etc; Cook Meth N/S
3100044000 212 90 1.97% Beef, meat

- Cooked; Fresh or N/S; Boiled
3100046000 210 450 1.97% Beef, meat bypro ducts

- Cooked; Fresh or N/S; Cook Meth
N/S
Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including dupli cates)

Food N Percent Food Name

---------- ----- ------- ------------- 3100044000 2970 64.01% Beef, meat
3100047000 2880 22.66% Beef, fat
3600222000 1080 3.59% Milk, fat

3100049000 90 2.80% Beef, liver 3100046000 630 2.34% Beef, meat byproducts

================================================================================ Children 3

- 5 Low percentile for CEC records: 99 Exposure (mg/day) = 0.002209
High percentile for CEC records: 99.9 Exposure (mg/day) = 0.004791

Number of actual records in this interval: 2250

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates)
%=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name

---------- --- ----- ------- ------------- 3100044000 210 1260 28.25% Beef, meat

- Cooked; Fresh or N/S; Cook Meth N/S

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

______________________________________________________________________________

Page 25 of 27 31000440 00 213 900 24.14% Beef, meat

- Cooked; Fresh or N/S; Fried
3100047000 210 1260 13.76% Beef, fat

- Cooked; Fresh or N/S; Cook Meth N/S
3100044000 211 450 10.02% Beef, meat

- Cooked; Fresh or N/S; Baked

3100047000 213 810 4.96% Beef, fat

- Cooked; Fresh or N/S; Fried
3100044000 212 90 4.07% Beef, meat

- Cooked; Fresh or N/S; Boiled
3200169000 210 90 3.01% Goat, meat

- Cooked; Fresh or N/S; Cook Meth N/S
3600222000 110 990 2.72% Milk, fat

- Uncooked; Fresh or N/S; Cook Meth N/S
3100046000 210 540 1.91% Beef, meat byproducts

- Cooked; Fresh or N/S; Cook Meth
N/S

Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name

---------- ----- ------- ------------- 3100044000 2880 67.14% Beef, meat
3100047000 2520 20.01% Beef, fat
3600222000 1260 3.41% Milk, fat
3200169000 90 3.01% Goat, meat 3100046000 540 1.91% Beef, meat byproducts



### Attachment 11 : Excerpt for the Drinking Water Calculation for 50x T AF for the O xon

parent/date conc.ppm oxon/date conc.ppm taf50 combine Steady State

11/11/1961 0.00E+00 11/11/1961 0.00E+00 0.00E+00 0.00E+00 4.55E

- 06

11/12/1961 0.00E+00 11/12/1961 0.00E+00 0.00E+00 0.00E+00 4.70E

- 06

11/13/1961 6.83E

- 06 11/13/1961 1.95E

- 08 9.75E

- 07 7.81E

- 06 4.83E

- 06

11/14/1961 6.44E

- 06 11/14/1961 1.87E

- 08 9.35E

- 07 7.38E

- 06 4.59E

- 06

11/15/1961 6.07E

- 06 11/15/1961 1.79E

- 08 8.95E

- 07 6.97E

- 06 4.37E

- 06

11/16/1961 5.73E

- 06 11/16/1961 1.72E

- 08 8.60E

- 07 6.59E

- 06 4.16E

- 06

11/17/1961 5.41E

- 06 11/17/1961 1.65E

- 08 8.25E

- 07 6.24E

- 06 3.96E

- 06

11/18/1961 5.11E

- 06 11/18/1961 1.58E

- 08 7.90E

- 07 5.90E

- 06 3.77E

- 06

11/19/1961 4.83E

- 06 11/19/1961 1.52E

- 08 7.60E

- 07 5.59E

- 06 3.60E

- 06

11/20/1961 4.57E

- 06 11/20/1961 1.46E

- 08 7.30E

- 07 5.30E

- 06 3.44E

- 06

11/21/1961 4.33E

- 06 11/21/1961 1.40E

- 08 7.00E

- 07 5.03E

- 06 3.29E

- 06 Taf50= oxon conc multiply by 50 Combine= TAF50 added by parent conc Steady State= combine values 1 to 21 were average. Next values 2 to 22 were average and so on...



### Attachment 1 2 : Residue Distribution File (RDF) for Honey

Attachment 12 : Residue Distribution File (RDF) for Honey

### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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### Coumaphos Dietary Exposure and Risk Assessment DP No: D412870

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