Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM

Date: 26-October-2011

Subject: Difenoconazole. Acute and Chronic Aggregate Dietary Exposure and Risk 

Assessments for the Amended Section 3 Registration to Add Seed Treatment Uses on 

Oats and Rye. 

PC Code: 128847 DP Barcode: 389652

Decision No.: 440121 Registration No.: None

Petition Nos.: 0F7785 Regulatory Action: Amended Section 3

Assessment Type: Single Chemical, Dietary Registration Case No.: NA

TXR No.: None CAS No.: 119446-68-3

MRID No.: None 40 CFR: 180.475

Reviewer: Thurston G. Morton, Chemist

Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through: Dennis McNeilly Chemist

David Hrdy, Senior Scientist

Dietary Exposure Science Advisory Council (DESAC)

And

Susan V. Hummel, Senior Chemist

RABIV/HED (7509P)

To: Rebecca Daiss, Risk Assessor

RABIV/HED (7509P)

And

Elissa Reaves, Branch Chief

RABIV/HED (7509P)

And

Tony Kish

Fungicide Branch/RD (7505P)
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Executive Summary

Aggregate (food + water) acute and chronic dietary risk assessments were conducted using the 

Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID, ver. 

2.03). This model uses food consumption data from the United States Department of 

Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII; 1994-1996 

and 1998). The analyses were performed to support an amended Section 3 registration to add 

seed treatment uses on oats and rye of the fungicide difenoconazole [1-[2-[2-chloro-4-(4-

chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole]. 

The unrefined acute analysis assumed tolerance-level residues, maximum expected residues for

wheat grain and barley grain from field trials with a lower method limit of quantitation (LOQ) , 

100% crop treated (CT), and the available empirical or DEEM (ver. 7.81) default processing 

factors. The EDWC of 15.8 μg/L (ppb) was used for the acute dietary exposure analysis and an 

EDWC of 10.4 μg/L (ppb) was used for the chronic dietary exposure analysis.

The resulting acute food plus water exposure estimates were less than HED’s level of concern (-

<100% of the acute population-adjusted dose (aPAD)) at the 95th percentile of the exposure 

distribution for the general U.S. population (8 % aPAD) and all population sub-groups; the most 

highly exposed population subgroup was children1 - 2 years old with 19 % aPAD. The 

somewhat refined chronic analysis assumed tolerance-level residues for some commodities, 

average field trial residues for the majority of commodities, the available empirical or DEEM

(ver. 7.81) default processing factors, and 100 % CT. The resulting chronic food plus water 

exposure estimates were less than HED’s level of concern (<100% of the chronic populationadjusted dose (cPAD)) for the general U.S. population (18 % cPAD) and all population subgroups; the most highly exposed population subgroup was children 1 - 2 years old with 46 % 

cPAD. 

The requested amended uses of difenoconazole did not result in an increase in dietary 

exposure estimates for free triazole or conjugated triazoles. Therefore, the last dietary 

exposure analyses for the triazole metabolites (D388469, T. Morton, 27 Apr. 2011) will not 

need to be updated and still applies.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, 

NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 
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from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (3-

March-2011; DP#378938).

II. Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock: The HED Metabolism Assessment Review 

Committee (MARC) has determined that for tolerance expression and risk assessment purposes, 

the residue of concern is difenoconazole per se for plant and livestock commodities. The 

MARC, however, stated that if tolerances are proposed for difenoconazole resulting from foliar 

uses which result in higher residue levels of CGA-205375 than parent, then the need to include 

CGA-205375 should be reconsidered (Memo, G. Kramer, 22-JUL-1994; No DP#). Because the 

petitioner has now proposed foliar uses of difenoconazole, which result in higher residues in crop 

commodities, the need to include metabolite CGA 205375 in the tolerance expression and/or risk 

assessment has been re-examined. Based upon a review of the previously-submitted metabolism 

data for difenoconazole, HED concludes the residue of concern for both tolerance setting and risk 

assessment for the crops included in this petition is difenoconazole. However, HED concludes 

the residue of concern in livestock for tolerance setting and risk assessment are difenoconazole 

and its metabolite CGA 205375 (for more details, see the summary document, DP# 340379). 

Table 1 below summarizes tolerance expression and the residues of concern in plant and 

livestock commodities. 

Table 1. Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants Primary and Rotational crops Parent Only Parent Only

Livestock Ruminant and Poultry Parent and CGA 205375 Parent and CGA 205375

Drinking Water Parent Only NA

No new residue data was submitted to support an amended Section 3 registration to add seed 

treatment uses on oats and rye. These amended uses are covered by previously submitted residue 

data. The amended uses of difenoconazole do not increase the livestock dietary burden and does 

not affect the livestock tolerances.

Previously Recommended Tolerances: Based on the residue chemistry data submitted with the 

previous petitions, HED recommended for establishment of the new food tolerances (DP# 

366507, B. Cropp-Kohlligian, 23-Feb-2011). The newly recommended, established, and revised 

tolerances are listed in Table 2 below.
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Table 2. Tolerance Summary for Difenoconazole (non feed items).

Commodity Existing/Established 

Tolerances (ppm)

New Tolerances (ppm)

Almond, nutmeat 0.03 ------

Brassica subgroup 5A 1.9 ------

Brassica subgroup 5B 35 ------

Citrus oil 25 ------

Fruit, citrus, group 10 0.6 ------

Grape 4.0 ------

Grape, raisin 6.0 ------

Nut, tree, group 14 0.03 ------

Onion, bulb, subgroup 3—07A 0.20 ------

Onion, green, subgroup 3—07B 6.0 ------

Pistachios 0.03 ------

Vegetable, cucurbit, group 9 0.7 ------

Fruit, Pome, group 11 1.0 ------

Vegetable, Fruiting, Group 8 0.60 ------

Vegetable, Tuberous and Corm, 

subgroup 1C

0.01 ------

Beet, sugar 0.30 ------

Papaya 0.30 ------

Banana 0.2 ------

Barley, grain 0.1 0.10

Canola, seed 0.01 ------

Cattle fat 0.10 ------

Cattle, meat 0.05 ------

Cattle, meat byproducts 0.10 ------

Cattle, liver 0.40 ------

Corn, sweet, kernel plus cob 

with husks removed

0.01 ------

Cotton, undelinted seed 0.05 ------

Egg 0.02 ------

Goat, fat 0.10 ------

Goat, meat 0.05 ------

Goat, meat byproducts (except 

liver)

0.10 ------

Goat, liver 0.40 ------

Hog, fat 0.10 ------

Hog, meat 0.05 ------

Hog, meat byproducts (except 

liver)

0.1 ------

Hog, liver 0.40 ------

Horse, fat 0.10 ------

Horse, meat 0.05 ------

Horse, meat byproducts (except 0.10 ------
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Table 2. Tolerance Summary for Difenoconazole (non feed items).

Commodity Existing/Established 

Tolerances (ppm)

New Tolerances (ppm)

liver)

Horse, liver 0.40 ------

Milk 0.01 ------

Rye, grain 0.1 0.01

Sheep, fat 0.10 ------

Sheep, meat 0.05 ------

Sheep, meat byproducts (except 

liver)

0.10 ------

Sheep, liver 0.40 ------

Wheat, grain 0.1 0.10

Wax apple 0.07 ------

Mango 0.07 ------

Carrot ------ 0.50

Chickpea ------ 0.08

Soybean, seed ------ 0.15

Fruit, stone, group 12 ------ 2.5

Strawberry ------ 2.5

Turnip greens ------ 35

Oat, grain ------ 0.01

The requested amended uses of difenoconazole did not result in an increase in dietary 

exposure estimates for free triazole or conjugated triazoles. Therefore, the last dietary 

exposure analyses for the triazole metabolites (D388469, T. Morton, 27 Apr. 2011) will not 

need to be updated.
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Food Residues and processing factors used in the Acute and Chronic Analysis: The acute 

analysis assumed tolerance-level residues, maximum expected residues for wheat grain and 

barley grain from field trials with a lower method LOQ, and 100% CT for all the registered and 

proposed crops. Tolerance-level residues were also assumed for all livestock tissues in this 

assessment. The chronic analysis assumed tolerance-level residues for some commodities, 

average field trial residues for the majority of commodities, and 100 % CT. Those commodities 

where field trial data were used are summarized below. HED SOP 2000.1 Guidance for 

Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation 

to Other Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to 

other commodities in the crop group. Experimental processing factors were used for apple juice 

(0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), 

raisin (3.5x chronic only since raisin tolerance used in acute), sugar beet molasses (0.6x), tomato 

paste (1.6x), and tomato puree (0.5x); DEEM (ver. 7.81) default processing factors were 

assumed for other processed commodities. 

Almond: Field trial residues were used from MRID 47586101. 

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102. Residues from 1-7 day PHI were 

used since registered labels allow from 1-7 day PHIs.

Cabbage: Field trial residues were used from 47586102. Residues from 1-7 day PHI were used 

since registered labels allow from 1-7 day PHIs. To refine the dietary exposure data from only

cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI

were used since registered labels allow from 0-1 day PHI.

Carrot: Field trial residues were used from MRID 47929804.

Chickpea: Field trial residues were used from MRID 47929805.

Cucumber: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI

were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 

47586102. Residues from 1-7 day PHI were used since registered labels allow from 1-7 day

PHIs.
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Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 46950235.

Soybean: Field trial residues were used from MRID 47929801.

Stone Fruit: Field trial residues were used from MRID 47929803.

Strawberry: Field trial residues were used from MRID 47929802.

Sugar Beet: Field trial residues were used from MRID 46950236.

Summer Squash: Field trial residues were used from MRID 47586103. Residues from 0-1 day

PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

III. Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED; Memo, I. Maher, 1-June-2010; D371044). 

EFED conducted a Tier II drinking water assessment for surface water sources using the 

Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered 

and proposed new uses. Among all the registered and proposed new uses, the highest estimated 

drinking water concentrations (EDWCs) for surface water sources were derived for aerial 

applications of difenoconazole to New York grapes at the maximum annual application rate of 

0.46 lb ai/acre. The estimated drinking water residues for 1-in-10 year annual peak, 1-in-10 year 

annual mean, and 36-year annual mean are 15.8, 10.4, and 7.62 μg/L (ppb) respectively. 

The highest SCI-GROW estimated drinking water concentration of difenoconazole from shallow 

ground water sources is 1.28 x 10-2μg/L, obtained for the maximum application rate for 

ornamentals (0.52 lb ai/A; D333319). These concentrations can be considered as both the acute 

and chronic groundwater values. The EDWCs from ground water sources are expected to be the 

same for the proposed golf course turf uses as estimated for ornamentals.

The 1-in-10 year annual peak EDWC of 15.8 μg/L (ppb) was used for the acute dietary (food 

plus water) exposure analysis and the 1-in-10 year annual mean EDWC of 10.4 μg/L (ppb) was 

used for the chronic dietary (food plus water) exposure analysis.
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IV. DEEM-FCID Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994-

1996 and 1998). The 1994-96, 98 data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant 

differences in user vs. per capita exposure and risk are identified and noted in the risk 

assessment.
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V. Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review Committee (HIARC) 

evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 1994, 

as well as the toxicological endpoints for the dietary and occupational exposure risk assessments 

that were selected in 1994. At this meeting, the HIARC also addressed the potential enhanced 

sensitivity of infants and children from exposure to difenoconazole as required by the Food 

Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998). In July, 2007, 

the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the 

HIARC since new studies were submitted. RAB1 toxicologists and risk assessment team also 

reevaluated FQPA assessments. The risk assessment team concluded that the default 10x FQPA 

Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures

(M.Sahafeyan, D333320, 09-AUG-07). The relevant endpoints are shown in Table 3.

In accordance with HED’s current policy and EPA’s 2005 Cancer Guidelines, difenoconazole is 

classified as “Suggestive Evidence of Carcinogenic Potential,” based on excessive toxicity

observed at the two highest doses, the absence of tumors at the lower doses and the absence of 

genotoxic effects. A margin-of-exposure (MOE) approach in risk assessment was advocated by

HED’s CPRC in 1994. Use of an MOE approach was reviewed and reaffirmed in 2007 by the 

CPRC Chair (PV Shah, 3/1/07, HED Doc. No. 0054532). 

Therefore, a separate cancer dietary assessment is not being conducted for difenoconazole.

Table 3. Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk 

Assessments. 

Exposure 

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, for Risk 

Assessment

Study and Relevant 

Toxicological Effects

Acute Dietary 

(All 

populations)

NOAEL = 

25

mg/kg

UFA = 10X

UFH = 10X

FQPA SF = 1X 

aRfD = aPAD = 0.25 

mg/kg/day

Acute Neurotoxicity Study 

in Rats

LOAEL= 200 mg/kg in 

males based on reduced 

fore-limb grip strength in 

males on day 1.

Chronic 

Dietary (All 

populations)

NOAEL = 

0.96

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

cRfD = cPAD = 

0.01mg/kg/day

Combined chronic 

toxicity/carcinogenicity 

(rat; dietary) LOAEL = 

24.1/32.8 mg/kg/day (M/F) 

based on cumulative 

decreases in body-weight 

gains.

Cancer (oral, 

dermal, 

inhalation)

Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) 

approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated 

March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of 

cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity 

among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population 

adjusted dose (a = acute, c = chronic). RfD = reference dose. 
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VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the 

DEEM-FCID (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID

estimating the dietary exposure of the U.S. population and various population subgroups. The 

results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively. 

The resulting acute food exposure estimates were less than HED’s level of concern (<100% 

aPAD) at the 95th percentile of the exposure distribution for general US population (8 % aPAD) 

and all population sub-groups; the most highly exposed population subgroup was Children 1-2 

years old with 19 % aPAD. The resulting chronic food exposure estimates were less than HED’s 

level of concern (<100% cPAD) for the general U.S. population (17 % cPAD) and all population 

sub-groups; the most highly exposed population subgroup was children 1-2 years old with 46 % 

cPAD. A separate cancer dietary assessment was not conducted for difenoconazole because the 

cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is 

considered protective of all chronic effects including carcinogenicity.

Table 4. Summary of Acute Dietary (Food plus Water) Exposure and Risk for Difenoconazole at the 95th

Percentile.

Population Subgroup aPAD (mg/kg/day) Exposure (mg/kg/day) %aPAD

General U.S. Population

0.25

0.020538 8

All Infants (< 1 year old) 0.039780 16

Children 1-2 years old 0.047638 19

Children 3-5 years old 0.037050 15

Children 6-12 years old 0.021576 9

Youth 13-19 years old 0.011240 5

Adults 20-49 years old 0.014699 6

Adults 50+ years old 0.019351 8

Females 13-49 years old 0.015084 6

The bolded %aPAD is the highest.
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Table 5. Summary of Chronic Dietary (Food plus Water) Exposure and Risk for Difenoconazole.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD

General U.S. Population

0.01

0.001687 17

All Infants (< 1 year old) 0.003001 30

Children 1-2 years old 0.004573 46

Children 3-5 years old 0.003607 36

Children 6-12 years old 0.002027 20

Youth 13-19 years old 0.001307 13

Adults 20-49 years old 0.001317 13

Adults 50+ years old 0.001562 16

Females 13-49 years old 0.001373 14

The bolded %cPAD is the highest.

 

VII. Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, maximum expected residues for wheat 

grain and barley grain from field trials with a lower method LOQ, 100% CT, and empirical or 

DEEM default processing factors. The chronic analysis assumed tolerance-level residues for 

some commodities, average field trial residues for the majority of commodities, 100 % CT, and 

empirical or DEEM default processing factors. Therefore, these analyses are considered 

conservative. While they could be significantly refined, further refinement is not warranted as 

estimated risks are not of concern. 

VIII. Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole 

using the DEEM-FCID (ver. 2.03) Model and assumed tolerance-level residues, maximum 

expected residues for wheat grain and barley grain from field trials with a lower method LOQ , 

100% CT, and empirical or DEEM default processing factors. The chronic aggregate dietary

risk assessment assumed tolerance-level residues for some commodities, average field trial 

residues for the majority of commodities, 100 % CT, and empirical or DEEM default 

processing factors. The resulting acute and chronic aggregate exposure estimates were less than 

HED’s level of concern. For the general U.S. population, the aPAD and cPAD were 8 % and 17

%, respectively. The most highly-exposed population subgroups in the acute (at the 95th

percentile of the exposure distribution) and chronic analyses were Children 1-2 years old (19 % 

aPAD) and children 1-2 years old (46 % cPAD), respectively. 
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IX. Attachments

Attachment 1: DEEM-FCID Acute Residue File

Attachment 2: DEEM-FCID Acute Exposure Estimates

Attachment 3: DEEM-FCID Chronic Residue File

Attachment 4: DEEM-FCID Chronic Exposure Estimates

cc with all attachments: T. Morton (RABIV)

RDI: D. McNeilly and D. Hrdy - DESAC (26-October-2011); S. Hummel (26-October-2011)

Petition Number(s): 0F7785

DP#: 389652

PC Code: 128847

T. Morton:S10838:PY1:(703)305-6691
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Attachment 1: DEEM-FCID Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 

0F7785 May 2011\difenoconazole_acute-05-11.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 05-10-2011/07:02:12/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010520 1A Beet, sugar 0.300000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

01010780 1AB Carrot 0.500000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.500000 1.000 1.000 

01010790 1AB Carrot, juice 0.500000 1.000 1.000 

01032960 1C Potato, chips 0.010000 0.500 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.010000 0.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.010000 0.500 1.000 

01032980 1C Potato, flour 0.010000 0.500 1.000 

01032981 1C Potato, flour-babyfood 0.010000 0.500 1.000 

01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

03001980 3 Leek 6.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 6.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

05010610 5A Broccoli 1.900000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.900000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.900000 1.000 1.000 

05010640 5A Brussels sprouts 1.900000 1.000 1.000 

05010690 5A Cabbage 1.900000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 

05010830 5A Cauliflower 1.900000 1.000 1.000 

05011960 5A Kohlrabi 1.900000 1.000 1.000 

05020630 5B Broccoli raab 35.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000 

05021170 5B Collards 35.000000 1.000 1.000 

05021940 5B Kale 35.000000 1.000 1.000 

05022290 5B Mustard greens 35.000000 1.000 1.000 

05023180 5B Rape greens 35.000000 1.000 1.000 

05023890 5B Turnip, greens 35.000000 1.000 1.000 

06003470 6 Soybean, seed 0.150000 1.000 1.000 

06003480 6 Soybean, flour 0.150000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.150000 1.000 1.000 

06003490 6 Soybean, soy milk 0.150000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.150000 1.000 1.000 

06003500 6 Soybean, oil 0.150000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.150000 1.000 1.000 

06030980 6C Chickpea, seed 0.080000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.080000 1.000 1.000 

06030990 6C Chickpea, flour 0.080000 1.000 1.000 

08001480 8 Eggplant 0.600000 1.000 1.000 

08002340 8 Okra 0.600000 1.000 1.000 

08002700 8 Pepper, bell 0.600000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.600000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.600000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.600000 1.000 1.000 

08002720 8 Pepper, nonbell 0.600000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.600000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.600000 1.000 1.000 

08003740 8 Tomatillo 0.600000 1.000 1.000 

08003750 8 Tomato 0.600000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

14 of 22

08003751 8 Tomato-babyfood 0.600000 1.000 1.000 

08003760 8 Tomato, paste 0.600000 1.600 1.000 

08003761 8 Tomato, paste-babyfood 0.600000 1.600 1.000 

08003770 8 Tomato, puree 0.600000 0.500 1.000 

08003771 8 Tomato, puree-babyfood 0.600000 0.500 1.000 

08003780 8 Tomato, dried 0.600000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.600000 14.300 1.000 

08003790 8 Tomato, juice 0.600000 1.500 1.000 

09010750 9A Cantaloupe 0.700000 1.000 1.000 

09010800 9A Casaba 0.700000 1.000 1.000 

09011870 9A Honeydew melon 0.700000 1.000 1.000 

09013990 9A Watermelon 0.700000 1.000 1.000 

09014000 9A Watermelon, juice 0.700000 1.000 1.000 

09020210 9B Balsam pear 0.700000 1.000 1.000 

09020880 9B Chayote, fruit 0.700000 1.000 1.000 

09021020 9B Chinese waxgourd 0.700000 1.000 1.000 

09021350 9B Cucumber 0.700000 1.000 1.000 

09023080 9B Pumpkin 0.700000 1.000 1.000 

09023090 9B Pumpkin, seed 0.700000 1.000 1.000 

09023560 9B Squash, summer 0.700000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.700000 1.000 1.000 

09023570 9B Squash, winter 0.700000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.700000 1.000 1.000 

10001060 10 Citrus citron 0.600000 1.000 1.000 

10001070 10 Citrus hybrids 0.600000 1.000 1.000 

10001080 10 Citrus, oil 25.000000 1.000 1.000 

10001800 10 Grapefruit 0.600000 1.000 1.000 

10001810 10 Grapefruit, juice 0.600000 0.100 1.000 

10001970 10 Kumquat 0.600000 1.000 1.000 

10001990 10 Lemon 0.600000 1.000 1.000 

10002000 10 Lemon, juice 0.600000 0.100 1.000 

10002001 10 Lemon, juice-babyfood 0.600000 0.100 1.000 

10002010 10 Lemon, peel 0.600000 1.000 1.000 

10002060 10 Lime 0.600000 1.000 1.000 

10002070 10 Lime, juice 0.600000 0.100 1.000 

10002071 10 Lime, juice-babyfood 0.600000 0.100 1.000 

10002400 10 Orange 0.600000 1.000 1.000 

10002410 10 Orange, juice 0.600000 0.100 1.000 

10002411 10 Orange, juice-babyfood 0.600000 0.100 1.000 

10002420 10 Orange, peel 0.600000 1.000 1.000 

10003070 10 Pummelo 0.600000 1.000 1.000 

10003690 10 Tangerine 0.600000 1.000 1.000 

10003700 10 Tangerine, juice 0.600000 0.100 1.000 

11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 

11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

11000090 11 Apple, dried 1.000000 8.000 1.000 

11000091 11 Apple, dried-babyfood 1.000000 8.000 1.000 

11000100 11 Apple, juice 1.000000 0.040 1.000 

11000101 11 Apple, juice-babyfood 1.000000 0.040 1.000 

11000110 11 Apple, sauce 1.000000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 1.000000 1.000 1.000 

11001290 11 Crabapple 1.000000 1.000 1.000 

11002100 11 Loquat 1.000000 1.000 1.000 

11002660 11 Pear 1.000000 1.000 1.000 

11002661 11 Pear-babyfood 1.000000 1.000 1.000 

11002670 11 Pear, dried 1.000000 6.250 1.000 

11002680 11 Pear, juice 1.000000 1.000 1.000 

11002681 11 Pear, juice-babyfood 1.000000 1.000 1.000 

11003100 11 Quince 1.000000 1.000 1.000 

12000120 12 Apricot 2.500000 1.000 1.000 

12000121 12 Apricot-babyfood 2.500000 1.000 1.000 

12000130 12 Apricot, dried 2.500000 1.000 1.000 

12000140 12 Apricot, juice 2.500000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 2.500000 1.000 1.000 

12000900 12 Cherry 2.500000 1.000 1.000 

12000901 12 Cherry-babyfood 2.500000 1.000 1.000 

12000910 12 Cherry, juice 2.500000 1.000 1.000 

12000911 12 Cherry, juice-babyfood 2.500000 1.000 1.000 

12002300 12 Nectarine 2.500000 1.000 1.000 

12002600 12 Peach 2.500000 1.000 1.000 

12002601 12 Peach-babyfood 2.500000 1.000 1.000 

12002610 12 Peach, dried 2.500000 1.000 1.000 

12002611 12 Peach, dried-babyfood 2.500000 1.000 1.000 

12002620 12 Peach, juice 2.500000 1.000 1.000 

12002621 12 Peach, juice-babyfood 2.500000 1.000 1.000 

12002850 12 Plum 2.500000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

15 of 22

12002851 12 Plum-babyfood 2.500000 1.000 1.000 

12002860 12 Plum, prune, fresh 2.500000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 2.500000 1.000 1.000 

12002870 12 Plum, prune, dried 2.500000 1.000 1.000 

12002871 12 Plum, prune, dried-babyfood 2.500000 1.000 1.000 

12002880 12 Plum, prune, juice 2.500000 1.000 1.000 

12002881 12 Plum, prune, juice-babyfood 2.500000 1.000 1.000 

14000030 14 Almond 0.030000 1.000 1.000 

14000031 14 Almond-babyfood 0.030000 1.000 1.000 

14000040 14 Almond, oil 0.030000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.030000 1.000 1.000 

14000590 14 Brazil nut 0.030000 1.000 1.000 

14000680 14 Butternut 0.030000 1.000 1.000 

14000810 14 Cashew 0.030000 1.000 1.000 

14000920 14 Chestnut 0.030000 1.000 1.000 

14001550 14 Filbert 0.030000 1.000 1.000 

14001560 14 Filbert, oil 0.030000 1.000 1.000 

14001850 14 Hickory nut 0.030000 1.000 1.000 

14002130 14 Macadamia nut 0.030000 1.000 1.000 

14002690 14 Pecan 0.030000 1.000 1.000 

14002820 14 Pistachio 0.030000 1.000 1.000 

14003910 14 Walnut 0.030000 1.000 1.000 

15000250 15 Barley, pearled barley 0.010000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.010000 1.000 1.000 

15000260 15 Barley, flour 0.010000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.010000 1.000 1.000 

15000270 15 Barley, bran 0.010000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15002310 15 Oat, bran 0.010000 1.000 1.000 

15002320 15 Oat, flour 0.010000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.010000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.010000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 

15003280 15 Rye, grain 0.010000 1.000 1.000 

15003290 15 Rye, flour 0.010000 1.000 1.000 

15004010 15 Wheat, grain 0.020000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.020000 1.000 1.000 

15004020 15 Wheat, flour 0.020000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.020000 1.000 1.000 

15004030 15 Wheat, germ 0.020000 1.000 1.000 

15004040 15 Wheat, bran 0.020000 1.000 1.000 

20003190 20 Rapeseed, oil 0.010000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.010000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.400000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.400000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.400000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.400000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.400000 1.000 1.000 

27002220 D Milk, fat 0.010000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

16 of 22

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

70001450 P Egg, whole 0.020000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.020000 1.000 1.000 

70001460 P Egg, white 0.020000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.020000 1.000 1.000 

70001470 P Egg, yolk 0.020000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.015800 1.000 1.000 

86020000 O Water, indirect, all sources 0.015800 1.000 1.000 

95000230 O Banana 0.200000 1.000 1.000 

95000231 O Banana-babyfood 0.200000 1.000 1.000 

95000240 O Banana, dried 0.200000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 

95001280 O Cottonseed, oil 0.050000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 

95001750 O Grape 4.000000 1.000 1.000 

95001760 O Grape, juice 4.000000 0.200 1.000 

95001761 O Grape, juice-babyfood 4.000000 0.200 1.000 

95001770 O Grape, leaves 4.000000 1.000 1.000 

95001780 O Grape, raisin 6.000000 1.000 1.000 

95001790 O Grape, wine and sherry 4.000000 1.000 1.000 

95002150 O Mango 0.070000 1.000 1.000 

95002151 O Mango-babyfood 0.070000 1.000 1.000 

95002160 O Mango, dried 0.070000 1.000 1.000 

95002170 O Mango, juice 0.070000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 

95002450 O Papaya 0.300000 1.000 1.000 

95002451 O Papaya-babyfood 0.300000 1.000 1.000 

95002460 O Papaya, dried 0.300000 1.800 1.000 

95002470 O Papaya, juice 0.300000 1.500 1.000 

95002830 O Plantain 0.200000 1.000 1.000 

95002840 O Plantain, dried 0.200000 3.900 1.000 

95003590 O Strawberry 2.500000 1.000 1.000 

95003591 O Strawberry-babyfood 2.500000 1.000 1.000 

95003600 O Strawberry, juice 2.500000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 2.500000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

17 of 22

Attachment 2: DEEM-FCID Acute Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE (1994-98 data)

Residue file: difenoconazole_acute-05-11.R98 Adjustment factor #2 used.

Analysis Date: 05-10-2011/07:05:35 Residue file dated: 05-10-2011/07:02:12/8

Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

U.S. Population:

 0.020538 8.22 0.055384 22.15 0.143944 57.58 

All infants:

 0.039780 15.91 0.062606 25.04 0.118345 47.34 

Children 1-2 yrs:

 0.047638 19.06 0.094024 37.61 0.252955 101.18 

Children 3-5 yrs:

 0.037050 14.82 0.076959 30.78 0.375828 150.33 

Children 6-12 yrs:

 0.021576 8.63 0.044683 17.87 0.148114 59.25 

Youth 13-19 yrs:

 0.011240 4.50 0.039654 15.86 0.137650 55.06 

Adults 20-49 yrs:

 0.014699 5.88 0.041863 16.75 0.109721 43.89 

Adults 50+ yrs:

 0.019351 7.74 0.063235 25.29 0.138873 55.55 

Females 13-49 yrs:

 0.015084 6.03 0.042143 16.86 0.121368 48.55 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

18 of 22

Attachment 3: DEEM-FCID Chronic Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 

0F7785 May 2011\difenoconazole_chronic-05-11AverageFT.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 05-10-2011/07:03:40/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010520 1A Beet, sugar 0.300000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

01010780 1AB Carrot 0.062000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.062000 1.000 1.000 

01010790 1AB Carrot, juice 0.062000 1.000 1.000 

01032960 1C Potato, chips 0.005000 0.500 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.005000 0.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.005000 0.500 1.000 

01032980 1C Potato, flour 0.005000 0.500 1.000 

01032981 1C Potato, flour-babyfood 0.005000 0.500 1.000 

01032990 1C Potato, tuber, w/peel 0.005000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.005000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.005000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.005000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

03001980 3 Leek 6.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 6.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

05010610 5A Broccoli 0.221000 1.000 1.000 

05010611 5A Broccoli-babyfood 0.221000 1.000 1.000 

05010620 5A Broccoli, Chinese 0.221000 1.000 1.000 

05010640 5A Brussels sprouts 29.000000 1.000 1.000 

05010690 5A Cabbage 0.029000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 0.029000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 0.221000 1.000 1.000 

05010830 5A Cauliflower 0.221000 1.000 1.000 

05011960 5A Kohlrabi 0.029000 1.000 1.000 

05020630 5B Broccoli raab 5.100000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 5.100000 1.000 1.000 

05021170 5B Collards 5.100000 1.000 1.000 

05021940 5B Kale 5.100000 1.000 1.000 

05022290 5B Mustard greens 5.100000 1.000 1.000 

05023180 5B Rape greens 5.100000 1.000 1.000 

05023890 5B Turnip, greens 5.100000 1.000 1.000 

06003470 6 Soybean, seed 0.021500 1.000 1.000 

06003480 6 Soybean, flour 0.021500 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.021500 1.000 1.000 

06003490 6 Soybean, soy milk 0.021500 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.021500 1.000 1.000 

06003500 6 Soybean, oil 0.021500 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.021500 1.000 1.000 

06030980 6C Chickpea, seed 0.017000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.017000 1.000 1.000 

06030990 6C Chickpea, flour 0.017000 1.000 1.000 

08001480 8 Eggplant 0.133000 1.000 1.000 

08002340 8 Okra 0.600000 1.000 1.000 

08002700 8 Pepper, bell 0.133000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.133000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.133000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.133000 1.000 1.000 

08002720 8 Pepper, nonbell 0.133000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.133000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.133000 1.000 1.000 

08003740 8 Tomatillo 0.165000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

19 of 22

08003750 8 Tomato 0.165000 1.000 1.000 

08003751 8 Tomato-babyfood 0.165000 1.000 1.000 

08003760 8 Tomato, paste 0.165000 1.600 1.000 

08003761 8 Tomato, paste-babyfood 0.165000 1.600 1.000 

08003770 8 Tomato, puree 0.165000 0.500 1.000 

08003771 8 Tomato, puree-babyfood 0.165000 0.500 1.000 

08003780 8 Tomato, dried 0.165000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.165000 14.300 1.000 

08003790 8 Tomato, juice 0.165000 1.500 1.000 

09010750 9A Cantaloupe 0.137000 1.000 1.000 

09010800 9A Casaba 0.137000 1.000 1.000 

09011870 9A Honeydew melon 0.137000 1.000 1.000 

09013990 9A Watermelon 0.137000 1.000 1.000 

09014000 9A Watermelon, juice 0.137000 1.000 1.000 

09020210 9B Balsam pear 0.055000 1.000 1.000 

09020880 9B Chayote, fruit 0.310000 1.000 1.000 

09021020 9B Chinese waxgourd 0.055000 1.000 1.000 

09021350 9B Cucumber 0.055000 1.000 1.000 

09023080 9B Pumpkin 0.031000 1.000 1.000 

09023090 9B Pumpkin, seed 0.031000 1.000 1.000 

09023560 9B Squash, summer 0.031000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.031000 1.000 1.000 

09023570 9B Squash, winter 0.031000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.031000 1.000 1.000 

10001060 10 Citrus citron 0.208000 1.000 1.000 

10001070 10 Citrus hybrids 0.208000 1.000 1.000 

10001080 10 Citrus, oil 25.000000 1.000 1.000 

10001800 10 Grapefruit 0.120000 1.000 1.000 

10001810 10 Grapefruit, juice 0.120000 0.100 1.000 

10001970 10 Kumquat 0.208000 1.000 1.000 

10001990 10 Lemon 0.176000 1.000 1.000 

10002000 10 Lemon, juice 0.176000 0.100 1.000 

10002001 10 Lemon, juice-babyfood 0.176000 0.100 1.000 

10002010 10 Lemon, peel 0.176000 1.000 1.000 

10002060 10 Lime 0.176000 1.000 1.000 

10002070 10 Lime, juice 0.176000 0.100 1.000 

10002071 10 Lime, juice-babyfood 0.176000 0.100 1.000 

10002400 10 Orange 0.208000 1.000 1.000 

10002410 10 Orange, juice 0.208000 0.100 1.000 

10002411 10 Orange, juice-babyfood 0.208000 0.100 1.000 

10002420 10 Orange, peel 0.208000 1.000 1.000 

10003070 10 Pummelo 0.120000 1.000 1.000 

10003690 10 Tangerine 0.208000 1.000 1.000 

10003700 10 Tangerine, juice 0.208000 0.100 1.000 

11000070 11 Apple, fruit with peel 0.203000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.203000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.203000 1.000 1.000 

11000090 11 Apple, dried 0.203000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.203000 8.000 1.000 

11000100 11 Apple, juice 0.203000 0.040 1.000 

11000101 11 Apple, juice-babyfood 0.203000 0.040 1.000 

11000110 11 Apple, sauce 0.203000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.203000 1.000 1.000 

11001290 11 Crabapple 0.203000 1.000 1.000 

11002100 11 Loquat 0.123000 1.000 1.000 

11002660 11 Pear 0.123000 1.000 1.000 

11002661 11 Pear-babyfood 0.123000 1.000 1.000 

11002670 11 Pear, dried 0.123000 6.250 1.000 

11002680 11 Pear, juice 0.123000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.123000 1.000 1.000 

11003100 11 Quince 0.123000 1.000 1.000 

12000120 12 Apricot 0.421000 1.000 1.000 

12000121 12 Apricot-babyfood 0.421000 1.000 1.000 

12000130 12 Apricot, dried 0.421000 1.000 1.000 

12000140 12 Apricot, juice 0.421000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.421000 1.000 1.000 

12000900 12 Cherry 0.622000 1.000 1.000 

12000901 12 Cherry-babyfood 0.622000 1.000 1.000 

12000910 12 Cherry, juice 0.622000 1.000 1.000 

12000911 12 Cherry, juice-babyfood 0.622000 1.000 1.000 

12002300 12 Nectarine 0.421000 1.000 1.000 

12002600 12 Peach 0.421000 1.000 1.000 

12002601 12 Peach-babyfood 0.421000 1.000 1.000 

12002610 12 Peach, dried 0.421000 1.000 1.000 

12002611 12 Peach, dried-babyfood 0.421000 1.000 1.000 

12002620 12 Peach, juice 0.421000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.421000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

20 of 22

12002850 12 Plum 0.295000 1.000 1.000 

12002851 12 Plum-babyfood 0.295000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.295000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.295000 1.000 1.000 

12002870 12 Plum, prune, dried 0.295000 2.600 1.000 

12002871 12 Plum, prune, dried-babyfood 0.295000 2.600 1.000 

12002880 12 Plum, prune, juice 0.295000 1.000 1.000 

12002881 12 Plum, prune, juice-babyfood 0.295000 1.000 1.000 

14000030 14 Almond 0.005000 1.000 1.000 

14000031 14 Almond-babyfood 0.005000 1.000 1.000 

14000040 14 Almond, oil 0.005000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.005000 1.000 1.000 

14000590 14 Brazil nut 0.007000 1.000 1.000 

14000680 14 Butternut 0.007000 1.000 1.000 

14000810 14 Cashew 0.007000 1.000 1.000 

14000920 14 Chestnut 0.005000 1.000 1.000 

14001550 14 Filbert 0.007000 1.000 1.000 

14001560 14 Filbert, oil 0.007000 1.000 1.000 

14001850 14 Hickory nut 0.007000 1.000 1.000 

14002130 14 Macadamia nut 0.007000 1.000 1.000 

14002690 14 Pecan 0.007000 1.000 1.000 

14002820 14 Pistachio 0.005000 1.000 1.000 

14003910 14 Walnut 0.007000 1.000 1.000 

15000250 15 Barley, pearled barley 0.010000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.010000 1.000 1.000 

15000260 15 Barley, flour 0.010000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.010000 1.000 1.000 

15000270 15 Barley, bran 0.010000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15002310 15 Oat, bran 0.010000 1.000 1.000 

15002320 15 Oat, flour 0.010000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.010000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.010000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 

15003280 15 Rye, grain 0.010000 1.000 1.000 

15003290 15 Rye, flour 0.010000 1.000 1.000 

15004010 15 Wheat, grain 0.020000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.020000 1.000 1.000 

15004020 15 Wheat, flour 0.020000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.020000 1.000 1.000 

15004030 15 Wheat, germ 0.020000 1.000 1.000 

15004040 15 Wheat, bran 0.020000 1.000 1.000 

20003190 20 Rapeseed, oil 0.010000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.010000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.400000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.400000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.400000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.400000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.400000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

21 of 22

27002220 D Milk, fat 0.010000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

70001450 P Egg, whole 0.020000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.020000 1.000 1.000 

70001460 P Egg, white 0.020000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.020000 1.000 1.000 

70001470 P Egg, yolk 0.020000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.010400 1.000 1.000 

86020000 O Water, indirect, all sources 0.010400 1.000 1.000 

95000230 O Banana 0.200000 1.000 1.000 

95000231 O Banana-babyfood 0.200000 1.000 1.000 

95000240 O Banana, dried 0.200000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 

95001280 O Cottonseed, oil 0.050000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 

95001750 O Grape 0.613000 1.000 1.000 

95001760 O Grape, juice 0.613000 0.200 1.000 

95001761 O Grape, juice-babyfood 0.613000 0.200 1.000 

95001770 O Grape, leaves 0.613000 1.000 1.000 

95001780 O Grape, raisin 0.613000 3.500 1.000 

95001790 O Grape, wine and sherry 0.613000 1.000 1.000 

95002150 O Mango 0.070000 1.000 1.000 

95002151 O Mango-babyfood 0.070000 1.000 1.000 

95002160 O Mango, dried 0.070000 1.000 1.000 

95002170 O Mango, juice 0.070000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 

95002450 O Papaya 0.300000 1.000 1.000 

95002451 O Papaya-babyfood 0.300000 1.000 1.000 

95002460 O Papaya, dried 0.300000 1.800 1.000 

95002470 O Papaya, juice 0.300000 1.500 1.000 

95002830 O Plantain 0.200000 1.000 1.000 

95002840 O Plantain, dried 0.200000 3.900 1.000 

95003590 O Strawberry 0.495000 1.000 1.000 

95003591 O Strawberry-babyfood 0.495000 1.000 1.000 

95003600 O Strawberry, juice 0.495000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.495000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 389652

PC Code: 128847

22 of 22

Attachment 4: DEEM-FCID Chronic Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for DIFENOCONAZOLE (1994-98 data)

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

Difenoconazole 0F7785 May 2011\difenoconazole_chronic-05-11AverageFT.R98

 Adjustment factor #2 used.

Analysis Date 05-10-2011/07:07:12 Residue file dated: 05-10-2011/07:03:40/8

Reference dose (RfD, Chronic) = .01 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.001687 16.9%

U.S. Population (spring season) 0.001678 16.8%

U.S. Population (summer season) 0.001793 17.9%

U.S. Population (autumn season) 0.001618 16.2%

U.S. Population (winter season) 0.001659 16.6%

Northeast region 0.001620 16.2%

Midwest region 0.001651 16.5%

Southern region 0.001578 15.8%

Western region 0.001956 19.6%

Hispanics 0.001605 16.1%

Non-hispanic whites 0.001609 16.1%

Non-hispanic blacks 0.001946 19.5%

Non-hisp/non-white/non-black 0.002414 24.1%

All infants (< 1 year) 0.003001 30.0%

Nursing infants 0.001638 16.4%

Non-nursing infants 0.003518 35.2%

Children 1-6 yrs 0.003782 37.8%

Children 7-12 yrs 0.001901 19.0%

Females 13-19 (not preg or nursing) 0.001191 11.9%

Females 20+ (not preg or nursing) 0.001484 14.8%

Females 13-50 yrs 0.001445 14.5%

Females 13+ (preg/not nursing) 0.001325 13.3%

Females 13+ (nursing) 0.001582 15.8%

Males 13-19 yrs 0.001419 14.2%

Males 20+ yrs 0.001323 13.2%

Seniors 55+ 0.001597 16.0%

Children 1-2 yrs 0.004573 45.7%

Children 3-5 yrs 0.003607 36.1%

Children 6-12 yrs 0.002027 20.3%

Youth 13-19 yrs 0.001307 13.1%

Adults 20-49 yrs 0.001317 13.2%

Adults 50+ yrs 0.001562 15.6%

Females 13-49 yrs 0.001373 13.7%

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