US EPA FOCUS MEETINGCYHALOFOPBUTYLDow AgroSciencesJuly 11 2014-July11,2014AgendaRegulatory Overview & Product ProfileCharge QuestionsQ & A|2Regulatory Overview•Postemergence herbicide for selective control of grass weeds in rice> Drydrill-seeded> Water-seeded•Excellent selectivity on all rice varieties and rice hybrids•Aryloxyphenoxypropionate chemical familypropionatechemicalfamily•Inhibits the Acetyl CoA Carboxylase (ACCase) enzyme|3Regulatory Overview•1996 – First registrations in Philippines and Japan•2000 – Cyhalofop-butyl was granted Reduced Risk Pesticidedesignation in rice.•2007 – EPA classified cyhalofop-butyl as “Not Likely to beCarcinogenic to Humans.”•2009 – EPA removed temporary registration status and otherrestrictions tocyhalofop-butyland ClincherformulationsrestrictionstocyhalofopandClincherformulations.Products currently are registered in all key major rice growing countries.|4EPA Charge Questions &DAS ResponsesDiscuss locations of useacross the country. These are of particularimportance to focus our endangered species assessment.gpArkansas, California, Louisiana, Mississippi, Missouri, and Texas|5EPA Charge Questions &DAS ResponsesDiscuss the spectrum of plants that are affected by the mechanism ofaction for this chemical.Only grasses are affected by the mechanism of action of cyhalofop-butyl.Cyhalofop-butyl has no activityon any broadleaf or sedge weeds.|6EPA Charge Questions &DAS ResponsesDiscuss Dow AgroSciences plan for wild rice.Dow AgroSciences does not intend to label this use.|7EPA Charge Questions &DAS ResponsesCan Dow AgroSciences provide a bibliography of studies for any datadeveloped for Europe or elsewhere?pYes. This list will be provided via email.|8EPA Charge Questions &DAS ResponsesCan Dow clarify all labels with the term “post-flood.” For example, inwater-seeded rice,is the “postflood” application theperiod after thepflood for seeding, or application period after permanent flood?Post-flood refers to any time afterseeding that the fields are flooded withwater and that grass weeds would be present in the rice. Thus, postflood can be both of the examples provided.|9EPA Charge Questions &DAS ResponsesClincher DR is referenced as a supplemental application product toClincher GR(southern states). Is Clincher DR a registeredproduct?)pClincher DR is an alternate brand name for Clincher GR as reflected onthe EPA Notice of Registration and stamped approved label datedSeptember 30, 2010.|10EPA Charge Questions &DAS ResponsesHow is Clincher used in the ratoon rice production process?Very little Clincher is used in ratoon rice. An estimated 50 gallons perseason is applied which – at the 15 oz/acre rate – would treat lessthan 500 acres. It is typically usedas a spot spray, not broadcast, tocontrol patches of grass weeds.|11EPA Charge Questions &DAS ResponsesHow are buffer zones established? Buffer distances for the samecommodityvaryamonglabels. Inparticular,for endangered species,y g p , g p ,the RebelEX has a smaller distance for the Southern States thanCalifornia.Buffer zones are established with modeling and actual drift studies.An additional safety margin was applied for the products used in CAbecause of the local conditions.|12EPA Charge Questions &DAS ResponsesWhy can the granule formulations be only applied to “water-seeded”rice? It seems that thegranule could be applied to “dry-seeded” ricepp ysince the granule is applied to flooded waters.The Clincher granule can only be used to control grasses that arecompletely (>80%) submerged at the 1-3 leaf vegetativestage. Water-seeded rice maintains a flood, and grass weeds can becontrolled while small (1-3 leaf stage) and submerged. However, bythe time dry-seeded rice is flooded, grass foliage needed for productuptake is neither submerged nor small, and foliage is not availableunderwater for herbicide uptake.|13ADDITIONAL QUESTIONS?Thank you!® Trademark of The Dow Chemical Company(“Dow”) or an affiliated company of Dow