Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 2 of 26 **E xecutive Summary**  Acute and chronic dietary risk assessments were conducted for fluxapy roxad using the Dietary Exposure Evaluation Model with the Food Commodity Intake Database (DEEM
- FCIDTM, Ver sion 2.03), which uses food consumption data from the USDA’s Continuing Survey s of Food Intakes b y Individuals (CSFII) from 1994
- 1996 and 1998. The anal ys is was performed to assess the use fluxapy

roxad as a new active ingredient on small grains, oilseeds, corn, cotton, sugar beet, tubers & corm vegetables, legumes, fruiting vegetables except cucurbits, pome fruits and stone fruits. Acute Dietary

Exposure Analysis Results and Characterization A conservative acute dietary exposure anal ys is was performed for the general population and all population subgroup s . T olerance level residues adjusted to account for the metabolites of concern (M700F008, M700F010) and 100 % crop treated assumptions were used. DEEM def ault and empirical processing factors were used to modify the tolerance values. The acute anal ys is incorporated the 1 in 10 year peak surface drinking water estimate from application of fluxapy roxad to dry

shelled beans
. The resulting 9 5 th percentile acute exposure estimate s are not of concern for the general population or for any subgroup population. The 95 th 

### percentile acute population adjusted dose (aPAD) for children 1
- 2 years old, the subgroup with the highest risk estimate, is 6 %. The 95 th 

### percentile aPAD for the general population is 2 %. Chronic Dietary

Exposure Anal ys is Results and Characterization A moderatel y refined chronic dietary exposure analy sis was performed for the general U.S. population and various population subgroups. Highest average field trial (HAFT) residues for parent plus metabolite were used for all plant commodities . For livestock commodities tolerance level residues adjusted to account for the metabolites of concern (M700F008, M700F010) were used. An assumption of 100 % crop treated was also used for the chronic dietary anal ys is
. DEEM default and empirical processing factors were used to modify the tolerance values. The chronic analysis incorporated the 10 year average surface drinking water estimate from application of fluxapy

roxad to dry

shelled beans
. Chronic dietary risk estimates are not of concern for general population or other populatio n subgroups. The population subgroup with the highest risk estimate is children 1
- 2 years old with a % chronic PAD (cPAD) of 48 %. The % cPAD for the general U.S. population is 1 4 %. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 3 of 26 For acute and non
- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one million. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21
- JUN
- 2000, web link: http://www.epa.gov/fedrgstr/EPA
- _PEST/2000/July

/Day
-_12/6061.pdf ; or see SOP 99.6 (20
- AUG
- 1999). This is the first dietary

risk assessment for fluxapy roxad. **II. Residue Information**  Residues of Concern The metabolism of fluxapy roxad has been studied in plants and livestock. The nature of the residue in plants is adequately understood based on soy bean, tomato , and wheat metabolism studies. The residue s of concern in primary and rotational plant commodities for risk assessment purposes are the parent co mpound , fluxapy roxad, and the M700F008 metabolite, as determined b y the HED Residues of Concern Knowledge Base Subcommittee (ROCKS). The nature of the residue in ruminants and poultry is adequatel y understood based on acceptable metabolism studies on lact ating goats and laying hens . Except for milk, the residues of concern in ruminant and poultry

commodities fo r risk assessment purposes are the parent and the M700F008 metabolite. The residues of concern for milk are the parent and the M700F008 and M700F0 10 metabolites. The residue of concern in water as determined b y ROCKS is parent only
. (D 390225 , I
. Negrón
- Encarnación , 7/14/11) **Table 1: Summary of Metabolites and Degradates to be included in the Risk Assessment and Tolerance**  **Expression Matrix**  **Residues of Concern** 1 **For Risk Assessment For Tolerance Expression**  Plants Primary Crop Fluxapyroxad and M700F008 Fluxapyroxad

Rotational Crop Fluxapyroxad and M700F008 Fluxapyroxad Livestock Ruminant Fluxapyroxad, M700F008 and M700F010 2 Fluxapyroxad Poultry Fluxapyroxad and M700F008 Fluxapyroxad Drinking Water Fluxapyroxad Fluxapyroxad 1 Fluxapyroxad is 3
- (difluoromethyl)
- 1
- methyl
-N
- (3 ′, 4′ ,5′
- trifluoro[1,1 ′
- biphenyl]
- 2
- yl)
- 1 H
- pyrazole
- 4
- carboxamide. M700F008 is 3
- (difluoromethyl)
-N
- (3 ′,4 ′,5 ′
- trifluorobiphenyl
- 2
- yl)pyrazole
- 4
- carboxamide. M700F010 is 3
- (difluoromethyl)
-N
- (hydroxy
3',4',5'
- trifluoro[1,1'
- biphenyl]
- 2
-yl)
- 1H
- py razole
- 4
- carboxamide 2 The metabolite M700F010 will be considered a residue of concern for milk only. 

### Recommended Tolerances No tolerances are established for fluxapy roxad. Tolerances have been recommended for the residues of the herbicide fluxapy roxad, including its metabolites and degradates, in or on the commodities listed in Table 2. C ompliance with the tolerance levels specified below is to beFluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 4 of 26 determined b y measuring only fluxapyroxad [ 3
- (difluoromethyl)
- 1
- methyl
-N
- (3 ′,4′,5′
- trifluoro[1,1 ′
- biphenyl ]
- 2
- yl )
- 1 H
-py razole
- 4
- carboxamide ] in or on the commodity
. **Table 2. Recommended Tolerances for Proposed New Uses of Fluxapyroxad** 

**Crop Group or Commodity Proposed Tolerance (ppm)**  Apple, wet pomace 3.5 Barley, bran 6 Beet, sugar
-- Beet , sugar, dried pulp 0.16 Beet, sugar , tops 4 Cattle, fat 0.1 Cattle, kidney 0.01 Cattle, liver 0.1 Cattle, meat 0.01 Cattle, meat byproducts 0.1 Corn, field, grain 0.1 Corn, oil, refined 0.05 Corn, pop, grain
-- Corn, sweet, kernels plus cobs with husks removed
-- Cotton , undelinted seed 0.01 Cotton , gin byproducts 0.01 Egg 0.01 F ruit , pome, group 11 0.7 F ruit , stone, group 1 2 1.4 G oat, fat 0.1 G oat, kidney 0.01 G oat, liver 0.1 Goat , meat 0.01 G oat , meat byproducts 0.1 Grain, aspirated fractions 16.0 Grain, cereal, group 15, except field corn grain 2.5 Grain, cereal, forage, fodder and straw, group 16 25 Hog, fat 0.01 Hog, liver 0.01 Hog , meat 0.01 Hog, meat byproducts 0.01 H orse, fat 0.1 Horse , kidney 0.01 Horse , liver 0.1 Horse , meat 0.01 Horse , meat by

products 0. 1 Milk 0.02 Milk, fat 0.1 Oilseeds, group 20 0.6 Peanut 0.02 Peanut , refined oil 0.06 Peanut, meal 0.03 Plum, prune 4Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 5 of 26 **Table 2. Recommended Tolerances for Proposed New Uses of Fluxapyroxad** 

**Crop Group or Commodity Proposed Tolerance (ppm)**  Potato, wet peel 0.2 Poultry, byproducts 0.01 Poultry , fat 0.01 Poultry , liver 0.01 Poultry , meat 0.01 Poultry, skin 0.01 Rapeseed, (cultivars/varieties and/or hybrids including canola and crambe 0.60 Rice, bran 4.5 Rice hull s 10 S heep, fat 0.1 S heep, kidney 0.01 S heep, liver 0.1 S heep , meat 0.01 Sheep, meat byproducts 0.1 Soy bean, hulls 6.5 Soy bean , seed 0.2 Sunflower, seed 0.6 0 Vegetable, Foliage of legume , group 7 18 V egetables , Fruiting, group 8 0.6 Vegetable, l egume , dried shelled (except soybean) subgroup 6C 0.35 Vegetable, legume, edible podded, subgroup 6A 1.4 Vegetable, legume, succulent shelled, subgroup 6B 0.45 Vegetable, root, subgroup 1A 0.1 Vegetable, tuberous and corm, subgroup 1C 0.04 Vegetable, tuberous and corm, except potato, subgroup 1 D 0.04 Wheat, bran 6 Wheat, germ 3 Wheat, grain
-- 

### Residues U sed in the Acute and Chronic Anal ys is A conservative acute dietary anal ys is was conducted using tolerance level residues for the parent , fluxapy roxad , multiplied by

a factor of 1.5x to account for the M700F008 metabolite for plant commodities . The 1.5x is a conservative factor derived from the ratio of metabolite to parent from the field trial data for pepper , the commodity with the highest metabolite to parent ratio for any commodity
. For animal commodities (except milk), tolerance level residues were adjusted for based on the specific ratio of metabolite to parent for each commodity . For milk, the tolerance was combined with the residue estimates for the two metabolites identified as residues of concern from the feeding study, M700F008 and M700F010
.Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 6 of 26 For the chronic dietary

analysis for plant commodities , the combined highest average field trial (HAFT) residues for parent plus M700F008 metabolite were used. For animal commodities, the combined residues derived for the acute assessment were used (i.e., tolerance level residues adjusted based on the specific ratio of metabolite to parent for each commodity). An assumption of 100% crop treated was used for both acute and chronic dietary assessments. Tolerances for animal commodities were derived using field study residue data for the parent and metabolite ( s) of concern adjusted for feeding study level and for calculated dietary burden. Based on livestock feedstuffs associated with proposed uses, the dietary burdens of fluxapy

roxad and M700F008 to livestock are estimated to be 3.1 ppm for beef cattle, 12.3 ppm for dairy cattle, and 0. 49 ppm for poultry
. Processing studies were provided for processed commodities associated with cereal grains, oil seed crops (canola and sunflower), peanuts, pome fruit, stone fruit, root and tuber vegetables (potatoes and sugar beets), and fruiting vegetables. Processing factors were reduced to 1x for most commodities based on processing data provided by the registrant. Residues used in the acute and chronic dietary anal ys is are provided in Table s 3 and 4
. Processing factors used in the acute and chronic dietary assessments that are greater than 1x or are different from default processing factors are provided in Table 5
. **Table 3**  **. Plant Commodity**  **Residue Estimates Used in the Fluxapyroxad Acute and Chronic Dietary/Drinki ng**  **Water Analysis**
**Comm odity**  **Residues Used in Dietary Exposure Assessment (ppm) Acute**  **1 Chronic**  **Tolerance Parent** 

**Plus Me** **tabolite Parent HAFT**  **Me tabolite**  **HAFT Equiv**  **2 Parent** 

**Plus Me** **tabolite** Beet, sugar, root 0.1 0.15 0.06 0.005 0.07 Crop Subgroup 1C
. Vegetable, tuberous and corm 0.02 0.03 0.02 0.005 0.03 Crop Subgroup 6A. Vegetable, legume, edible podded 2 3.0 Pea succ seed w pod 0.95 0.02 0.97 Soy bean succ seed w pod 0.69 0.05 0.74 Crop Subgroup 6B. Pea and bean, succulent shelled 0.5 0.75 Pea succ seed w /o pod 0.05 0.005 0.06 Soy bean succ seed w/o pod 0.37 0.02 0.39 Crop Subgroup 6C. Pea and bean, dried shelled (except soybean) 0.4 0.6 Pea, dried seed 0.16 0.005 0.17 Soy bean dried seed 0.1 0.005 0.11 Bean dried seed 0.21 0.03 0.24 Crop Group 8

– 10
. Vegetable, f

ruiting 0.5 0.75 Tomato 0.44 0.005 0.45 Bell Pepper 0.3 0.14 0.45 Non Bell 0.3 0.02 0.32 Crop Group 11
. Fruit, p ome 0.8 1.2 Apple 0.37 0.08 0.45 Pear 0.47 0.01 0.48 Other Pome fruit 0.47 0.01 0.48 Crop Group 12 . Fruit, stone 2.0 3.0 Peach 0.63 0.08 0.71 Cherry 1.05 0.3 1.36 Plum 0.95 0.01 0.96Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 7 of 26 **Table 3**  **. Plant Commodity**  **Residue Estimates Used in the Fluxapyroxad Acute and Chronic Dietary/Drinki ng**  **Water Analysis**
**Comm odity**  **Residues Used in Dietary Exposure Assessment (ppm) Acute**  **1 Chronic**  **Tolerance Parent** 

**Plus Me** **tabolite Parent HAFT**  **Me tabolite**  **HAFT Equiv**  **2 Parent** 

**Plus Me** **tabolite** Other Stone fruit 1.05 0.3 1.36 P lum, prune , dried 3.0 4.5 Plum, prune , dried 2.66 0.028 2.69 Crop Group 15 . Grain, cereal, group ( except field corn , pop, sweet, wheat, grain, wheat, bran) 3.0 4.5 Barley 1.22 0.02 1.24 Rice 1.77 0.03 1.80 Sorghum 0.4 0.06 0.46 Other grain, cereal 1.77 0.03 1.80 Wheat, bran 0.6 0 0.9 Wheat bran 0.38 .06 0.44 Wheat, grain 0.3 0.45 Wheat grain 0.19 0.03 0.22 Crop Group 20
. Oilseeds, 0.9 1.35 Canola 0.27 0.07 0.34 S unflower 0.13 0.005 0.14 C orn, field, grain , pop, sweet 0.01 5 0.0 23 0.01 0.005 0.005 0.01 C orn, pop 0.01 0.015 0.005 0.005 0.01 Cotton seed, oil 0.01 0.015 <0.01 <0.01 0.01 P eanut 0.01 0.015 0.005 0.005 0.01 P eanut, refined oil 0.0 2 0.0 3 0.005 0.005 0.01 1 T olerance level residues for the parent, fluxapyroxad multiplied by a factor of 1.5x to account for the M700F008 metabolite fo r plant commodities i.e., Tolerance x (1 + metabolite/parent) where metabolite/parent = 0.15/0.3 for bell pepper. 2 Metabolite HAFT equivalent = 1.038 * M700F008 where 1.038 = MW BAS 700 F / M700F008 (381.3/367.3). **Table 4**  **. Livestock Commodity Residue Estimates Used in Acute and Chronic Dietary/Drinking Water**  **Analysis**
**Tissue Feeding Level**  **- 60 ppm**  **Residues Used in Acute and Chronic Dietary Exposure Assessment (ppm)**  **Residue Fluxapyroxad**  **(ppm) Residue** 

**M700F008 (ppm)**  **Tolerance Me** **tabolites of Concern**  **Residue for**

**Risk Assessment**  Egg 0.045 0.013 0.00 2 0.001 0.00 3 Milk 0.015 0.016 0.00 5 0.006 0.0 11 Cattle, goat, horse, sheep fat 0.085 0.26 0.0 5 0.0 23 0.0 7 3 Cattle goat, horse, sheep meat 0.014 0.05 0.01 0.0 25 0.0 35 Cattle goat, horse, sheep 0.009 meat byproducts 0.011 0.024 0.03 0. 075 0. 105 Tolerance (ppm) = Residue of Fluxapyroxad x Dietary Burden (12.3 ppm)/ Feeding Level (60 ppm) Total residues (ppm) = BAS 700 F (ppm) + [1.038 * M700F008] where, 1.038 = MW BAS 700 F / M700F008 (381.3/367.3). For milk, M700 F010 is included in the risk assessment. Residues of M700F010 were approximately the same as the residues of parent fluxapyroxad (BAS 700F), so it is added in at the same level as BAS 700F. **Table 5**  **. Processing Factors Used in Fluxapyroxad Acute and**  **Chronic Dietary/Drinking Water Analysis**

**Comm odity**  **Processing Factor Comment**  Apples , dried , juice/cider 1 Reduced from default of 8.0 Apples , juice/cider 1 Reduced from default of 1.3 Apricots, dried 2.8 Reduced from default of 6.0 Beef, meat, dried 1.92 DefaultFluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 8 of 26 Cherries, juice, juice babyfood 1.5 Default Corn, field, oil, oil
-babyfood 2.6 Increased from default of 1.0 Corn, field, syrup, syrup
-babyfood 1.5 Default Peach, dried, dried
-babyfood, 2.8 Reduced from default of 7.0 Peanut, butter 1 Reduced from default of 1.89 Pear, dried 6.25 Default Plum, prune dried, dried
-babyfood 1 Reduced from default of 5.0 Plum, prune, juice, juice
-babyfood 1.4 Default Potato, dry, dry
-babyfood 4 Reduced from default of 6.5 Tomatoes, juice 1 Reduced from default of 1.5 Tomatoes, paste 1 Reduced from default of 5.4 Tomatoes, puree 1 Reduced from default of 3.3 Tomatoes, dried 14.3 Default 

### III. **Water Data** Drinking water residues were incorporated directly into the acute and chronic dietary analyses as “water, direct, all sources” and “water, indirect, all sources.” Estimated Drinking Water Concentrations (EDWCs) for fluxapy roxad were provided b y the Environmental Fate and Effects Division (EFED) (D138009, C. Peck, 9/21/11). EFED generated the surface water estimates using the Tier I aquatic model FIRST (FQPA Index Reservoir Screening Tool) . Ground water estimates were calculated using the Tier 1 Screening Concentration in Ground Water model (SCI
- GROW). EDWCs for fluxapy roxad (parent only) were derived based on fluxapy roxad use on dry shelled beans (except soy beans) at 0.18 lbs ai/acre/application, applied 2 times per year with a 7
- day

reapplication interval for a maximum total annual application rate of 0.36 lb ai/A/y r. S 

### urface and groundwater EDWCs for fluxapy roxad are provi ded in Table 6
. The e stimated drinking water residue level for peak concentration of 0. 014 mg/L(ppm) was used in the acute assessment . The estimated 30 year annual average drinking water concentration of 0. 0067 mg/L (ppm) was used the chronic assessment
. **Table 6**  **. EDWCs for the Fluxapyroxad**  **Human Health Risk Assessment Drinking Water Source**  **Peak (μg/L)**  **Annual Mean (μg/L)** Surface Water 14.1 6.7 Ground Water 0.087 0. 08 7 

### IV. **DEEM -**  **FCIDTM Program and Consumption Information** Fluxapy roxad chronic dietary

exposure assessments were conducted using DEEM
- FCIDTM (Version 2.03), which incorporates consumption data from USDA’s CSFII (1994
- 1996 and 1998). The 1994
- 96, 98 data are based on the reported consumption of more than 20,000 in dividuals over two non
- consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA
- defined food commodities (e.g. apples, peeled fruit
- cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicl y availab le recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on anal ys is of theFluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 9 of 26 1994
- 96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 ye ar old), children 1
- 2, children 3
- 5, children 6
- 12, youth 13
- 19, adults 20
- 49, females 13
- 49, and adults 50+ years old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food
form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. **V. Toxicological Information**  HED evaluated the toxicology data base for fluxapy

roxad and selected doses and endpoints for dietary risk assessments provided in Table 7
. **Table 7**  **. Toxicological Doses and Endpoints for Fluxapyroxad for Use in Dietary Human Health Risk Assessments**  **Exposure/ Scenario**  **Point of**

**Departure Uncertainty/** 

**FQPA Safety Factors**  **RfD & PAD Study and Toxicological Effects**  Ac ute Dietary (General Population) NOAEL= 125

mg/kg/day UF A= 10 x

UF H=10 x FQPA SF= 1x Ac ute RfD =

1.25 mg/kg/day aPAD= 1.25 mg/kg/day Ac ute neurotoxicity study in rats

LOAEL = 500 mg/kg/day based on decreased mo tor activity (both sexes) and decreased rearing (males only) Chronic Dietary (All Populations) NOAEL= 2.1

mg/kg/day UF A= 10 x

UF H=10 x FQPA SF= 1x Chronic RfD=

0.021 mg/kg/day cPAD = 0.021 mg/kg/day Chronic toxicity/carcinogenicity study in rats

LOAEL = 11 mg/kg/day based on non
- neoplastic changes in the liver (foci, masses)

Cancer (all routes) Classification: Not likely to be carcinogenic to humans at doses sufficient to induce liver and/or thyroid

tumors. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose
- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspeci es). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 10 of 26 **VI. Results/Discussion**  As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM
- FCIDTM anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table s 6 and 7 are for the general U.S. Population, all infants (<1 ye ar old), children 1
- 2, children 3
- 5, children 6
- 12, youth 13
- 19, females 13
- 49, adults 20
- 49, and adults 50+ years. Results of Acute Dietary

Exposure Analy sis The results of the acute dietary exposure anal ys is are reported in Table 8
. **Table 8**  **. Summary of**  **Acute Dietary Exposure and Risk for**  **Fluxapyroxad Population Subgroup**  **a PAD (m**  **g/kg/day) Acute (9**  **5 th Percentile)**  **Exposure (mg/kg/day) %**  **a PAD**  General U.S. Population

1. 25 0.0 23 3 1 0 2 All Infants (< 1 year old) 0.0 740 82 6 Children 1
- 2 years old 0. 0 6 8058 5 Children 3
- 5 years old 0.0 472 41 4 Children 6
- 12 years old 0.026 755 2 Youth 13
- 19 years old 0.0 158 50 2 Adults 20
- 49 years old 0.0 167 30 1 Adults 50+ years old 0.0 138 5 5 1 Females 13
- 49 years old 0.0 142 6 4 1 

### Results of Chronic Dietary Exposure Analy sis The results of the chronic dietary exposure anal ys is are reported in T able 9
. **Table 9**  **. Summary of Chronic Dietary Exposure and Risk for**  **Fluxapyroxad Population Subgroup**  **cPAD (m g/kg/day)**  **Chronic Exposure (mg/kg/day)**  **% cPAD**  General U.S. Population

0.0 2 1 0.00 29 23 1 4 All Infants (< 1 year old) 0.00 84 74 4 0 Children 1
- 2 years old 0.0 10055 48 Children 3
- 5 years old 0.007 3 69 3 5 Children 6
- 12 years old 0.00 4011 19 Youth 13
- 19 years old 0.002 2 17 1 1 Adults 20
- 49 years old 0.002 204 1 1 Adults 50+ years old 0.00 200 7 1 0 Females 13
- 49 years old 0.00 19 8 6 10 

### VII. Characterization of Inputs/Outputs For the acute dietary

analysis, tolerance level residues adjusted b y a conservative factor for the metabolite and 100% crop treated assumptions were used for all treated commodities
. Fo r the chronic dietary

anal ys is, combined HAFTs for parent and metabolite and 100% crop treated assumptions were used. Commodity specific processing factors were used when available. Otherwise, default processing factors were used for all processed commodities. Residues do notFluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 11 of 26 warrant further refinement at this time. **V I**  **II. C**  **onclusions** Conservative acute and refined chronic dietary exposure anal ys es w ere performed for the general U.S. population and various population subgroups. The acute and chronic risk estimates are below HED’s level of concern. HED is confid ent the acut e and chronic dietary exposures to fluxapy roxad are not underestimated. **IX .**  **List of Attachments** 1. Acute DEEM
- FCID Residue Input File. 2. Results of Acute DEEM
- FCID Dietary Exposure Anal ys is. 3. Chronic DEEM
- FCID Residue Input File. 4. Results of Chronic DEEM
- FCID Dietary Exposure Anal ys is.Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 12 of 26 Attachment 1 Acute DEEM
- FCID Residue Input File Filename: J: \ Fluxapyroxad \ 138009acute12
- 13
- 11.R98 Chemical: Fluxapyroxad RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 1 mg/kg b w/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 12

- 13
- 2011/11:47:31/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Ad j.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01010520 1A Beet, sugar 0.150000 1.000 1.000 010105 21 1A Beet, sugar
- babyfood 0.150000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.150000 1.000 1.000 01010531 1A Beet, sugar, molasses
- babyfood 0.150000 1.000 1.000 01030150 1CD Arrowroot, flour 0.030000 1.000 1.000 01030151 1CD Arrowroot, flour
- babyfood 0.030000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.030000 1.000 1.000 01030820 1CD Cassava 0.030000 1.000 1.000 01030821 1CD Cassava
- babyfood 0.030000 1.000 1.000 01031390 1CD Dasheen, corm 0.030000 1.000 1.000 01031660 1CD Ginger 0.030000 1.000 1.000 01031661 1CD Ginger
- babyfood 0.030000 1.000 1.000 01031670 1CD Ginger, dried 0.030000 1.000 1.000 01032960 1C Potato, chips 0.030000 1. 000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.030000 4.000 1.000 01032971 1C Potato, dry (granules/ flakes)

- b 0.030000 4.000 1.000 01032980 1C Potato, flour 0.030000 1.000 1.000 01032981 1C Pota to, flour
- babyfood 0.030000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.030000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 0.030000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.030000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 0.030000 1.000 1.000 01033660 1CD Sweet potato 0.030000 1.000 1.000 01033661 1CD Sweet potato
- babyfood 0.030000 1.000 1.000 01033 710 1CD Tanier, corm 0.030000 1.000 1.000 01033870 1CD Turmeric 0.030000 1.000 1.000 01034060 1CD Yam, true 0.030000 1.000 1.000 01034070 1CD Yam bean 0.030000 1.000 1.000 06003470 6 Soybean, seed 0.750000 1.000 1.000 06003480 6 Soybean, flour 0.750000 1.000 1.000 06003481 6 Soybean, flour
- babyfood 0.750000 1.000 1.000 06003490 6 Soybean, soy milk 0.750000 1.000 1.000 06003491 6 Soybean, soy milk
- babyfood or in 0.750000 1.000 1.000 06003500 6 Soybean, oil 0.750000 1.000 1.000 06003501 6 Soybean, oil
- babyfood 0.750000 1.000 1.000 06010430 6A Bean, snap, succulent 3.000000 1.000 1.000 06010431 6A Bean, snap, succulent
- babyfood 3.000000 1.000 1.000 06012570 6A Pea, edible podded, succulent 3.000000 1.000 1.000 06020310 6B Bean, broad, succulent 0.750000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.750000 1.000 1.000 06020370 6B Bean, lima, succu lent 0.750000 1.000 1.000 06022550 6B Pea, succulent 0.750000 1.000 1.000 06022551 6B Pea, succulent
- babyfood 0.750000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.750000 1. 000 1.000 06030300 6C Bean, black, seed 0.600000 1.000 1.000 06030320 6C Bean, broad, seed 0.600000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.600000 1.000 1.000 06030350 6C Bean , great northern, seed 0.600000 1.000 1.000 06030360 6C Bean, kidney, seed 0.600000 1.000 1.000 06030380 6C Bean, lima, seed 0.600000 1.000 1.000 06030390 6C Bean, mung, seed 0.600000 1.000 1.000 06030400 6C Bean, navy, seed 0.600000 1.000 1.000 06030410 6C Bean, pink, seed 0.600000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 13 of 26 06030420 6C Bean, pinto, seed 0.600000 1.000 1.000 06030 980 6C Chickpea, seed 0.600000 1.000 1.000 06030981 6C Chickpea, seed
- babyfood 0.600000 1.000 1.000 06030990 6C Chickpea, flour 0.600000 1.000 1.000 06031820 6C Guar, seed 0.600000 1.000 1.000 06031821 6C Guar, seed
- babyfood 0.600000 1.000 1.000 06032030 6C Lentil, seed 0.600000 1.000 1.000 06032560 6C Pea, dry 0.600000 1.000 1.000 06032561 6C Pea, dry
- babyfood 0.600000 1.000 1.000 06032580 6C Pea, pigeon, seed 0.600000 1.000 1.000 08002700 8 Pepper, bell 0.750000 1.000 1.000 08002701 8 Pepper, b ell
- babyfood 0.750000 1.000 1.000 08002710 8 Pepper, bell, dried 0.750000 1.000 1.000 08002711 8 Pepper, bell, dried
- babyfood 0.750000 1.000 1.000 08002720 8 Pepper, nonbell 0.750000 1.000 1.000 08002721 8 Pepper, nonbell
- babyfood 0.750000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.750000 1.000 1.000 08003740 8 Tomatillo 0.750000 1.000 1.000 08003750 8 Tomato 0.750000 1.000 1.000 08003751 8 Tomato
- babyfood 0.750000 1.000 1.000 08003760 8 Tomato, paste 0.750000 1. 000 1.000 08003761 8 Tomato, paste
- babyfood 0.750000 1.000 1.000 08003770 8 Tomato, puree 0.750000 1.000 1.000 08003771 8 Tomato, puree
- babyfood 0.750000 1.000 1.000 08003780 8 Toma to, dried 0.750000 14.300 1.000 08003781 8 Tomato, dried
- babyfood 0.750000 14.300 1.000 08003790 8 Tomato, juice 0.750000 1.000 1.000 11000070 11 Apple, fruit with peel 1.200000 1.000 1.000 11000080 11 Apple, peeled fruit 1.200000 1.000 1.000 11000081 11 Apple, peeled fruit
- babyfood 1.200000 1.000 1.000 11000090 11 Apple, dried 1.200000 1.000 1.000 11000 091 11 Apple, dried
- babyfood 1.200000 1.000 1.000 11000100 11 Apple, juice 1.200000 1.000 1.000 11000101 11 Apple, juice
- babyfood 1.200000 1.000 1.000 11000110 11 Apple, sauce 1.200000 1.000 1.000 11000111 11 Apple, sauce
- babyfood 1.200000 1.000 1.000 11001290 11 Crabapple 1.200000 1.000 1.000 11002100 11 Loquat 1.200000 1.000 1.000 11002660 11 Pear 1.200000 1.000 1.000 11002661 11 Pear
- babyfood 1.200000 1.000 1.000 11002670 11 Pear, dried 1.200000 6.250 1.000 11002680 11 Pear, juice 1.200000 1.000 1.000 11002681 11 Pear, juice
- babyfood 1.200000 1.000 1.000 11003100 11 Quince 1.200000 1.000 1.000 12000120 12 Apricot 3.000000 1.000 1.000 12000121 12 Apricot
- babyfood 3.000000 1.000 1.000 12000130 12 Apricot, dried 3.000000 2.800 1.000 12000140 12 Apricot, juice 3.000000 1. 000 1.000 12000141 12 Apricot, juice
- babyfood 3.000000 1.000 1.000 12000900 12 Cherry 3.000000 1.000 1.000 12000901 12 Cherry
- babyfood 3.000000 1.000 1.000 12000910 12 Cher ry, juice 3.000000 1.500 1.000 12000911 12 Cherry, juice
- babyfood 3.000000 1.500 1.000 12002300 12 Nectarine 3.000000 1.000 1.000 12002600 12 Peach 3.000000 1.000 1.000 12002601 12 Peach
- babyfood 3.000000 1.000 1.000 12002610 12 Peach, dried 3.000000 2.800 1.000 12002611 12 Peach, dried
- babyfood 3.000000 2.800 1.000 12002 620 12 Peach, juice 3.000000 1.000 1.000 12002621 12 Peach, juice
- babyfood 3.000000 1.000 1.000 12002850 12 Plum 3.000000 1.000 1.000 12002851 12 Plum
- babyfood 3.000000 1.000 1.000 12002860 12 Plum, prune, fresh 3.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 14 of 26 12002861 12 Plum, prune, fresh
- babyfood 3.000000 1.000 1.000 12002870 12 Plum, prune, dried 4.500000 1.000 1.000 12002871 12 Plum, prune, dried
- babyfood 4.500000 1.000 1.000 12002880 12 Plum, prune, juice 3.000000 1.400 1.000 12002881 12 Plum, prune, juice
- babyfood 3.000000 1.400 1.000 15000250 15 Barley, p earled barley 4.500000 1.000 1.000 15000251 15 Barley, pearled barley
- babyfood 4.500000 1.000 1.000 15000260 15 Barley, flour 4.500000 1.000 1.000 15000261 15 Barley, flour
- babyfood 4.500000 1.000 1.000 15000270 15 Barley, bran 4.500000 1.000 1.000 15000650 15 Buckwheat 4.500000 1.000 1.000 15000660 15 Buckwheat, flour 4.500000 1.000 1.000 15001200 15 Corn, field, flour 0.015000 1.000 1.000 15001201 15 Corn, field, flour
- babyfood 0.015000 1.000 1.000 15001210 15 Corn, field, meal 0.015000 1. 000 1.000 15001211 15 Corn, field, meal
- babyfood 0.015000 1.000 1.000 15001220 15 Corn, field, bran 0.015000 1.000 1.000 15001230 15 Corn, field, starch 0.015000 1.000 1.000 15001231 15 Corn , field, starch
- babyfood 0.015000 1.000 1.000 15001240 15 Corn, field, syrup 0.015000 1.500 1.000 15001241 15 Corn, field, syrup
- babyfood 0.015000 1.500 1.000 15001250 15 Corn, field, oil 0.015000 2.600 1.000 15001251 15 Corn, field, oil
- babyfood 0.015000 2.600 1.000 15001260 15 Corn, pop 0.015000 1.000 1.000 15001270 15 Corn, sweet 0.015000 1.000 1.000 15001 271 15 Corn, sweet
- babyfood 0.015000 1.000 1.000 15002260 15 Millet, grain 4.500000 1.000 1.000 15002310 15 Oat, bran 4.500000 1.000 1.000 15002320 15 Oat, flour 4.500000 1.000 1.000 15002321 15 Oat, flour
- babyfood 4.500000 1.000 1.000 15002330 15 Oat, groats/rolled oats 4.500000 1.000 1.000 15002331 15 Oat, groats/rolled oats

- babyfood 4.500000 1.000 1.000 15003230 15 Rice, white 4.500000 1.000 1.000 15003231 15 Rice, white
- babyfood 4.500000 1.000 1.000 15003240 15 Rice, brown 4.500000 1.000 1.000 15003241 15 Rice, bro wn - babyfood 4.500000 1.000 1.000 15003250 15 Rice, flour 4.500000 1.000 1.000 15003251 15 Rice, flour
- babyfood 4.500000 1.000 1.000 15003260 15 Rice, bran 4.500000 1.000 1.000 15003261 15 Rice, bran
- babyfood 4.500000 1.000 1.000 15003280 15 Rye, grain 4.500000 1.000 1.000 15003290 15 Rye, flour 4.500000 1.000 1.000 15003440 15 Sorghum, grain 4.500000 1.000 1.000 15003450 15 Sorghum, syrup 4.500000 1.000 1.000 15003810 15 Triticale, flour 0.450000 1. 000 1.000 15003811 15 Triticale, flour
- babyfood 0.450000 1.000 1.000 15004010 15 Wheat, grain 0.450000 1.000 1.000 15004011 15 Wheat, grain
- babyfood 0.450000 1.000 1.000 15004020 15 Whea t, flour 0.450000 1.000 1.000 15004021 15 Wheat, flour
- babyfood 0.450000 1.000 1.000 15004030 15 Wheat, germ 0.450000 1.000 1.000 15004040 15 Wheat, bran 0.900000 1.000 1.000 15004050 15 Wild rice 4.500000 1.000 1.000 20001630 20 Flaxseed, oil 1.350000 1.000 1.000 20003190 20 Rapeseed, oil 1.350000 1.000 1.000 20003 191 20 Rapeseed, oil
- babyfood 1.350000 1.000 1.000 20003300 20 Safflower, oil 1.350000 1.000 1.000 20003301 20 Safflower, oil
- babyfood 1.350000 1.000 1.000 20003640 20 Sunflower, seed 1.350000 1.000 1.000 20003650 20 Sunflower, oil 1.350000 1.000 1.000 20003651 20 Sunflower, oil
- babyfood 1.350000 1.000 1.000 21000440 M Beef, meat 0.035000 1.000 1.000 21000441 M Beef, meat
- babyfood 0.035000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 15 of 26 21000450 M Beef, meat, dried 0.035000 1.920 1.000 21000460 M Beef, meat byproducts 0.105000 1.000 1.000 21000461 M Beef, meat byproducts
- babyfood 0.105000 1.000 1.000 21000470 M Beef, fat 0.073000 1.000 1.000 21000471 M Beef,fat
- babyfood 0.073000 1.000 1.000 21000480 M Beef, kidney 0.105000 1.000 1.000 21000490 M Beef, liver 0.105000 1.000 1.000 21000491 M Beef, liver
- babyfood 0.105000 1.000 1.000 23001690 M Goat, meat 0.035000 1. 000 1.000 23001700 M Goat, meat byproducts 0.105000 1.000 1.000 23001710 M Goat, fat 0.073000 1.000 1.000 23001720 M Goat, kidney 0.105000 1.000 1.000 23001730 M Goat , liver 0.105000 1.000 1.000 24001890 M Horse, meat 0.035000 1.000 1.000 26003390 M Sheep, meat 0.035000 1.000 1.000 26003391 M Sheep, meat
- babyfood 0.035000 1.000 1.000 26003400 M Sheep, meat byproducts 0.105000 1.000 1.000 26003410 M Sheep, fat 0.073000 1.000 1.000 26003411 M Sheep, fat
- babyfood 0.073000 1.000 1.000 26003 420 M Sheep, kidney 0.105000 1.000 1.000 26003430 M Sheep, liver 0.105000 1.000 1.000 27002220 D Milk, fat 0.011000 1.000 1.000 27002221 D Milk, fat
- baby food/ infant for 0.011000 1.000 1.000 27012230 D Milk, nonfat solids 0.011000 1.000 1.000 27012231 D Milk, nonfat solids
- baby food/in 0.011000 1.000 1.000 27022240 D Milk, water 0.011000 1.000 1.000 27022241 D Milk, water
- babyfood/infant form 0.011000 1.000 1.000 27032251 D Milk, sugar (lactose)
- baby food/ 0.011000 1.000 1.000 70001450 P Egg, whole 0.004000 1.000 1.000 70001451 P Egg, whol e - babyfood 0.004000 1.000 1.000 70001460 P Egg, white 0.004000 1.000 1.000 70001461 P Egg, white (solids)
- babyfood 0.004000 1.000 1.000 70001470 P Egg, yolk 0.004000 1.000 1.000 70001471 P Egg, yolk
- babyfood 0.004000 1.000 1.000 86010000 O Water, direct, all sources 0.014100 1.000 1.000 86020000 O Water, indirect, all sources 0.014100 1.000 1.000 95001280 O Cottonseed, oil 0.015000 1.000 1.000 95001281 O Cottonseed, oil
- babyfood 0.015000 1.000 1.000 95002630 O Peanut 0.015000 1. 000 1.000 95002640 O Peanut, butter 0.015000 1.000 1.000 95002650 O Peanut, oil 0.030000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 16 of 26 Attachment 2 Chronic DEEM
- FCID Residue Input File Filename: J: \ Fluxapyroxad \ 138009chronic12
- 13
- 11HAFT.R98 Chemical: Fluxapyroxad RfD(Chronic): .09 mg/kg bw/day NOEL(Chronic): 9 mg/kg bw/day RfD(Acute): 1.25 mg/kg bw/day NOEL(Acute): 125 mg/kg bw/day Date created/last modified: 12

- 13
- 2011/11:45:17/8 Pro gram ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

----- --- ---- ------------------------------- ---------- ------ ------ ------- 01010500 1AB Beet, garden, roots 0.000000 1.000 1.000 01010501 1AB Beet, garden, roots
- babyfood 0.000000 1.000 1.000 01010520 1A Beet, sugar 0.070000 1.000 1.000 01010521 1A Beet, sugar
- babyfood 0.070000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.000000 1.000 1.000 01010531 1A Beet, sugar, molasses
- babyfood 0.000000 1.000 1.000 01010670 1AB Burdock 0.000000 1.000 1.000 01010780 1AB Carrot 0.000000 1.000 1.000 01010781 1AB Carrot
- babyfood 0.000000 1.000 1.000 01010790 1AB Ca rrot, juice 0.000000 1.000 1.000 01010840 1AB Celeriac 0.000000 1.000 1.000 01011000 1AB Chicory, roots 0.000000 1.000 1.000 01011680 1AB Ginseng, dried 0.000000 1.000 1.000 01011900 1AB Horseradish 0.000000 1.000 1.000 01012500 1AB Parsley, turnip rooted 0.000000 1.000 1.000 01012510 1AB Parsnip 0.000000 1.000 1.000 01012511 1AB Parsnip
- babyfood 0.000000 1.000 1.000 01013140 1AB Radish, roots 0.000000 1.000 1.000 01013160 1AB Radish, Oriental, roots 0.000000 1.000 1.000 01013270 1AB Rutabaga 0.000000 1.000 1.000 01013310 1AB Salsify, roots 0.000000 1.000 1.000 01013880 1AB Turnip, roots 0.000000 1.000 1.000 01030150 1CD Arrowroot, flour 0.000000 1. 000 1.000 01030151 1CD Arrowroot, flour
- babyfood 0.000000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.000000 1.000 1.000 01030820 1CD Cassava 0.000000 1.000 1.000 01030821 1CD Cass ava - babyfood 0.000000 1.000 1.000 01031390 1CD Dasheen, corm 0.000000 1.000 1.000 01031660 1CD Ginger 0.000000 1.000 1.000 01031661 1CD Ginger
- babyfood 0.000000 1.000 1.000 01031670 1CD Ginger, dried 0.000000 1.000 1.000 01032960 1C Potato, chips 0.030000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.030000 4.000 1.000 01032 971 1C Potato, dry (granules/ flakes)

- b 0.030000 4.000 1.000 01032980 1C Potato, flour 0.030000 1.000 1.000 01032981 1C Potato, flour
- babyfood 0.030000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.030000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 0.030000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.030000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 0.030000 1.000 1.000 01033660 1CD Sweet potato 0.030000 1.000 1.000 01033661 1CD Sweet potato
- babyfood 0.030000 1.000 1.000 01033710 1CD Tanier, corm 0.000000 1.000 1.000 01033870 1CD Turmeric 0.000000 1.000 1.000 01034060 1CD Yam, true 0.000000 1.000 1.000 01034070 1CD Yam bean 0.000000 1.000 1.000 02000510 2 Beet, garden, top s 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 17 of 26 02001010 2 Chicory, tops 0.000000 1.000 1.000 02001400 2 Dasheen, leaves 0.000000 1.000 1.000 02003150 2 Radish, tops 0.000000 1. 000 1.000 02003170 2 Radish, Oriental, tops 0.000000 1.000 1.000 02003320 2 Salsify, tops 0.000000 1.000 1.000 03001640 3 Garlic 0.000000 1.000 1.000 03001650 3 Garl ic, dried 0.000000 1.000 1.000 03001651 3 Garlic, dried
- babyfood 0.000000 1.000 1.000 03001980 3 Leek 0.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.000000 1.000 1.000 03002371 3 Onion, dry bulb
- babyfood 0.000000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.000000 1.000 1.000 03002381 3 Onion, dry bulb, dried
- babyfood 0.000000 1.000 1.000 03002 390 3 Onion, green 0.000000 1.000 1.000 03003380 3 Shallot 0.000000 1.000 1.000 04010050 4A Amaranth, leafy 0.000000 1.000 1.000 04010180 4A Arugula 0.000000 1.000 1.000 04011040 4A Chrysanthemum, garland 0.000000 1.000 1.000 04011330 4A Cress, garden 0.000000 1.000 1.000 04011340 4A Cress, upland 0.000000 1.000 1.000 04011380 4A Dandelion, leaves 0.000000 1.000 1.000 04011500 4A Endive 0.000000 1.000 1.000 04012040 4A Lettuce, head 0.000000 1.000 1.000 04012050 4A Lettuce, leaf 0.000000 1.000 1.000 04012480 4A Parsley, leaves 0.000000 1.000 1.000 04013130 4A Radicchio 0.000000 1.000 1.000 04013550 4A Spinach 0.000000 1.000 1.000 04013551 4A Spinach
- babyfood 0.000000 1.000 1.000 04020760 4B Cardoon 0.000000 1.000 1.000 04020850 4B Celery 0.000000 1.000 1.000 04020851 4B Celery
- babyfood 0.000000 1.000 1.000 04020860 4B Celery, juice 0.000000 1.000 1.000 04020870 4B Celtuce 0.000000 1. 000 1.000 04021520 4B Fennel, Florence 0.000000 1.000 1.000 04023220 4B Rhubarb 0.000000 1.000 1.000 04023670 4B Swiss chard 0.000000 1.000 1.000 05010610 5A Broc coli 0.000000 1.000 1.000 05010611 5A Broccoli
- babyfood 0.000000 1.000 1.000 05010620 5A Broccoli, Chinese 0.000000 1.000 1.000 05010640 5A Brussels sprouts 0.000000 1.000 1.000 05010690 5A Cabbage 0.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 0.000000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 0.000000 1.000 1.000 05010 830 5A Cauliflower 0.000000 1.000 1.000 05011960 5A Kohlrabi 0.000000 1.000 1.000 05020630 5B Broccoli raab 0.000000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 0.000000 1.000 1.000 05021170 5B Collards 0.000000 1.000 1.000 05021940 5B Kale 0.000000 1.000 1.000 05022290 5B Mustard greens 0.000000 1.000 1.000 05023180 5B Rape greens 0.000000 1.000 1.000 05023890 5B Turnip, greens 0.000000 1.000 1.000 06003470 6 Soybean, seed 0.110000 1.000 1.000 06003480 6 Soybean, flour 0.110000 1.000 1.000 06003481 6 Soybean, flour
- babyfood 0.110000 1.000 1.000 06003490 6 Soybean, soy milk 0.110000 1.000 1.000 06003491 6 Soybean, soy milk
- babyfood or in 0.110000 1.000 1.000 06003500 6 Soybean, oil 0.110000 1.000 1.000 06003501 6 Soybean, oil
- babyfood 0.110000 1.000 1.000 06010430 6A Bean, snap, succu lent 0.740000 1.000 1.000 06010431 6A Bean, snap, succulent
- babyfood 0.740000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.970000 1.000 1.000 06020310 6B Bean, broad, succulent 0.390000 1. 000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 18 of 26 06020330 6B Bean, cowpea, succulent 0.390000 1.000 1.000 06020370 6B Bean, lima, succulent 0.390000 1.000 1.000 06022550 6B Pea, succulent 0.060000 1.000 1.000 06022551 6B Pea, succulent
- babyfood 0.060000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.060000 1.000 1.000 06030300 6C Bean, black, seed 0.240000 1.000 1.000 06030320 6C Bean, broad, seed 0.240000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.240000 1.000 1.000 06030350 6C Bean, great northern, seed 0.240000 1.000 1.000 06030360 6C Bean, kidney, seed 0.240000 1.000 1.000 06030 380 6C Bean, lima, seed 0.240000 1.000 1.000 06030390 6C Bean, mung, seed 0.240000 1.000 1.000 06030400 6C Bean, navy, seed 0.240000 1.000 1.000 06030410 6C Bean, pink, seed 0.240000 1.000 1.000 06030420 6C Bean, pinto, seed 0.240000 1.000 1.000 06030980 6C Chickpea, seed 0.170000 1.000 1.000 06030981 6C Chickpea, seed
- babyfood 0.170000 1.000 1.000 06030990 6C Chickpea, flour 0.170000 1.000 1.000 06031820 6C Guar, seed 0.000000 1.000 1.000 06031821 6C Guar, seed
- babyfood 0.000000 1.000 1.000 06032030 6C Lentil, seed 0.000000 1.000 1.000 06032560 6C Pea, dry 0.170000 1.000 1.000 06032561 6C Pea, dry
- babyfood 0.170000 1.000 1.000 06032580 6C Pea, pigeon, seed 0.170000 1.000 1.000 08001480 8 Eggplant 0.000000 1.000 1.000 08002340 8 Okra 0.450000 1.000 1.000 08002700 8 Pepper, bell 0.450000 1. 000 1.000 08002701 8 Pepper, bell
- babyfood 0.450000 1.000 1.000 08002710 8 Pepper, bell, dried 0.450000 1.000 1.000 08002711 8 Pepper, bell, dried
- babyfood 0.450000 1.000 1.000 08002720 8 Pepp er, nonbell 0.320000 1.000 1.000 08002721 8 Pepper, nonbell
- babyfood 0.320000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.320000 1.000 1.000 08003740 8 Tomatillo 0.450000 1.000 1.000 08003750 8 Tomato 0.450000 1.000 1.000 08003751 8 Tomato
- babyfood 0.450000 1.000 1.000 08003760 8 Tomato, paste 0.450000 1.000 1.000 08003 761 8 Tomato, paste
- babyfood 0.450000 1.000 1.000 08003770 8 Tomato, puree 0.450000 1.000 1.000 08003771 8 Tomato, puree
- babyfood 0.450000 1.000 1.000 08003780 8 Tomato, dried 0.450000 14.300 1.000 08003781 8 Tomato, dried
- babyfood 0.450000 14.300 1.000 08003790 8 Tomato, juice 0.450000 1.000 1.000 09010750 9A Cantaloupe 0.000000 1.000 1.000 09010800 9A Casaba 0.000000 1.000 1.000 09011870 9A Honeydew melon 0.000000 1.000 1.000 09013990 9A Watermelon 0.000000 1.000 1.000 09014000 9A Watermelo n, juice 0.000000 1.000 1.000 09020210 9B Balsam pear 0.000000 1.000 1.000 09020880 9B Chayote, fruit 0.000000 1.000 1.000 09021020 9B Chinese waxgourd 0.000000 1.000 1.000 09021350 9B Cucumber 0.000000 1.000 1.000 09023080 9B Pumpkin 0.000000 1.000 1.000 09023090 9B Pumpkin, seed 0.000000 1.000 1.000 09023560 9B Squash, summer 0.000000 1.000 1.000 09023561 9B Squash, summer
- babyfood 0.000000 1.000 1.000 09023570 9B Squash, winter 0.000000 1. 000 1.000 09023571 9B Squash, winter
- babyfood 0.000000 1.000 1.000 10001060 10 Citrus citron 0.000000 1.000 1.000 10001070 10 Citrus hybrids 0.000000 1.000 1.000 10001080 10 Citr us, oil 0.000000 1.000 1.000 10001800 10 Grapefruit 0.000000 1.000 1.000 10001810 10 Grapefruit, juice 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 19 of 26 10001970 10 Kumquat 0.000000 1.000 1.000 10001990 10 Lemon 0.000000 1.000 1.000 10002000 10 Lemon, juice 0.000000 1.000 1.000 10002001 10 Lemon, juice
- babyfood 0.000000 1.000 1.000 10002 010 10 Lemon, peel 0.000000 1.000 1.000 10002060 10 Lime 0.000000 1.000 1.000 10002070 10 Lime, juice 0.000000 1.000 1.000 10002071 10 Lime, juice
- babyfood 0.000000 1.000 1.000 10002400 10 Orange 0.000000 1.000 1.000 10002410 10 Orange, juice 0.000000 1.000 1.000 10002411 10 Orange, juice
- babyfood 0.000000 1.000 1.000 10002420 10 Orange, peel 0.000000 1.000 1.000 10003070 10 Pummelo 0.000000 1.000 1.000 10003690 10 Tangerine 0.000000 1.000 1.000 10003700 10 Tangerine , juice 0.000000 1.000 1.000 11000070 11 Apple, fruit with peel 0.450000 1.000 1.000 11000080 11 Apple, peeled fruit 0.450000 1.000 1.000 11000081 11 Apple, peeled fruit
- babyfood 0.450000 1.000 1.000 11000090 11 Apple, dried 0.450000 1.000 1.000 11000091 11 Apple, dried
- babyfood 0.450000 1.000 1.000 11000100 11 Apple, juice 0.450000 1.000 1.000 11000101 11 Apple, juice
- babyfood 0.450000 1.000 1.000 11000110 11 Apple, sauce 0.450000 1.000 1.000 11000111 11 Apple, sauce
- babyfood 0.450000 1. 000 1.000 11001290 11 Crabapple 0.480000 1.000 1.000 11002100 11 Loquat 0.480000 1.000 1.000 11002660 11 Pear 0.480000 1.000 1.000 11002661 11 Pear
- babyfood 0.480000 1.000 1.000 11002670 11 Pear, dried 0.480000 1.000 1.000 11002680 11 Pear, juice 0.480000 1.000 1.000 11002681 11 Pear, juice
- babyfood 0.480000 1.000 1.000 11003100 11 Quince 0.480000 1.000 1.000 12000120 12 Apricot 1.360000 1.000 1.000 12000121 12 Apricot
- babyfood 1.360000 1.000 1.000 12000 130 12 Apricot, dried 1.360000 2.800 1.000 12000140 12 Apricot, juice 1.360000 1.000 1.000 12000141 12 Apricot, juice
- babyfood 1.360000 1.000 1.000 12000900 12 Cherry 1.360000 1.000 1.000 12000901 12 Cherry
- babyfood 1.360000 1.000 1.000 12000910 12 Cherry, juice 1.360000 1.500 1.000 12000911 12 Cherry, juice
- babyfood 1.360000 1.500 1.000 12002300 12 Nectarine 1.360000 1.000 1.000 12002600 12 Peach 0.710000 1.000 1.000 12002601 12 Peach
- babyfood 0.710000 1.000 1.000 12002610 12 Peach, dried 0.710000 2.800 1.000 12002611 12 Peach, dried
- babyfood 0.710000 2.800 1.000 12002620 12 Peach, juice 0.710000 1.000 1.000 12002621 12 Peach, juice
- baby food 0.710000 1.000 1.000 12002850 12 Plum 0.960000 1.000 1.000 12002851 12 Plum
- babyfood 0.960000 1.000 1.000 12002860 12 Plum, prune, fresh 0.960000 1. 000 1.000 12002861 12 Plum, prune, fresh
- babyfood 0.960000 1.000 1.000 12002870 12 Plum, prune, dried 2.690000 1.000 1.000 12002871 12 Plum, prune, dried
- babyfood 2.690000 1.000 1.000 12002880 12 Plum , prune, juice 0.960000 1.400 1.000 12002881 12 Plum, prune, juice
- babyfood 0.960000 1.400 1.000 13010550 13A Blackberry 0.000000 1.000 1.000 13010560 13A Blackberry, juice 0.000000 1.000 1.000 13010561 13A Blackberry, juice
- babyfood 0.000000 1.000 1.000 13010580 13A Boysenberry 0.000000 1.000 1.000 13011420 13A Dewberry 0.000000 1.000 1.000 13012 080 13A Loganberry 0.000000 1.000 1.000 13013200 13A Raspberry 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 20 of 26 13013201 13A Raspberry
- babyfood 0.000000 1.000 1.000 13013210 13A Raspberry, juice 0.000000 1.000 1.000 13013211 13A Raspberry, juice
- babyfood 0.000000 1.000 1.000 13020570 13B Blueberry 0.000000 1.000 1.000 13020571 13B Blueberry
- babyfood 0.000000 1.000 1.000 13021360 13B Currant 0.000000 1.000 1.000 13021370 13B Currant, dried 0.000000 1.000 1.000 13021490 13B Elderberry 0.000000 1.000 1.000 13021740 13B Gooseberr y 0.000000 1.000 1.000 13021910 13B Huckleberry 0.000000 1.000 1.000 14000030 14 Almond 0.000000 1.000 1.000 14000031 14 Almond
- babyfood 0.000000 1.000 1.000 14000040 14 Almond, oil 0.000000 1.000 1.000 14000041 14 Almond, oil
- babyfood 0.000000 1.000 1.000 14000590 14 Brazil nut 0.000000 1.000 1.000 14000680 14 Butternut 0.000000 1.000 1.000 14000810 14 Cashew 0.000000 1.000 1.000 14000920 14 Chestnut 0.000000 1. 000 1.000 14001550 14 Filbert 0.000000 1.000 1.000 14001560 14 Filbert, oil 0.000000 1.000 1.000 14001850 14 Hickory nut 0.000000 1.000 1.000 14002130 14 Maca damia nut 0.000000 1.000 1.000 14002690 14 Pecan 0.000000 1.000 1.000 14002820 14 Pistachio 0.000000 1.000 1.000 14003910 14 Walnut 0.000000 1.000 1.000 15000250 15 Barley, pearled barley 1.240000 1.000 1.000 15000251 15 Barley, pearled barley
- babyfood 1.240000 1.000 1.000 15000260 15 Barley, flour 1.240000 1.000 1.000 15000 261 15 Barley, flour
- babyfood 1.240000 1.000 1.000 15000270 15 Barley, bran 1.240000 1.000 1.000 15000650 15 Buckwheat 1.800000 1.000 1.000 15000660 15 Buckwheat, flour 1.800000 1.000 1.000 15001200 15 Corn, field, flour 0.010000 1.000 1.000 15001201 15 Corn, field, flour
- babyfood 0.010000 1.000 1.000 15001210 15 Corn, field, meal 0.010000 1.000 1.000 15001211 15 Corn, field, meal
- babyfood 0.010000 1.000 1.000 15001220 15 Corn, field, bran 0.010000 2.000 1.000 15001230 15 Corn, field, starch 0.010000 1.000 1.000 15001231 15 Corn, fie ld, starch
- babyfood 0.010000 1.000 1.000 15001240 15 Corn, field, syrup 0.010000 1.000 1.000 15001241 15 Corn, field, syrup
- babyfood 0.010000 1.000 1.000 15001250 15 Corn, field, oil 0.010000 2.600 1.000 15001251 15 Corn, field, oil
- babyfood 0.010000 2.600 1.000 15001260 15 Corn, pop 0.010000 1.000 1.000 15001270 15 Corn, sweet 0.010000 1.000 1.000 15001271 15 Corn, sweet
- babyfood 0.010000 1.000 1.000 15002260 15 Millet, grain 1.800000 1.000 1.000 15002310 15 Oat, bran 1.800000 1. 000 1.000 15002320 15 Oat, flour 1.800000 1.000 1.000 15002321 15 Oat, flour
- babyfood 1.800000 1.000 1.000 15002330 15 Oat, groats/rolled oats 1.800000 1.000 1.000 15002331 15 Oat, groats/rolled oats

- babyfood 1.800000 1.000 1.000 15003230 15 Rice, white 1.800000 1.000 1.000 15003231 15 Rice, white
- babyfood 1.800000 1.000 1.000 15003240 15 Rice, brown 1.800000 1.000 1.000 15003241 15 Rice, brown
- babyfood 1.800000 1.000 1.000 15003250 15 Rice, flour 1.800000 1.000 1.000 15003251 15 Rice, flour
- babyfood 1.800000 1.000 1.000 15003 260 15 Rice, bran 1.800000 1.000 1.000 15003261 15 Rice, bran
- babyfood 1.800000 1.000 1.000 15003280 15 Rye, grain 1.800000 1.000 1.000 15003290 15 Rye, flour 1.800000 1.000 1.000 15003440 15 Sorghum, grain 0.460000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 21 of 26 15003450 15 Sorghum, syrup 0.460000 1.000 1.000 15003810 15 Triticale, flour 0.220000 1.000 1.000 15003811 15 Triticale, flour
- babyfood 0.220000 1.000 1.000 15004010 15 Wheat, grain 0.220000 1.000 1.000 15004011 15 Wheat, grain
- babyfood 0.220000 1.000 1.000 15004020 15 Wheat, flour 0.220000 1.000 1.000 15004021 15 Wheat, flour
- babyfood 0.220000 1.000 1.000 15004030 15 Wheat, germ 0.220000 1.000 1.000 15004040 15 Wheat, bran 0.440000 1.000 1.000 15004050 15 Wild rice 1.800000 1.000 1.000 18000020 18 Alfalfa, seed 0.000000 1.000 1.000 19010280 19A Basil, fresh leaves 0.000000 1. 000 1.000 19010281 19A Basil, fresh leaves
- babyfood 0.000000 1.000 1.000 19010290 19A Basil, dried leaves 0.000000 1.000 1.000 19010291 19A Basil, dried leaves
- babyfood 0.000000 1.000 1.000 19011030 19A Chiv e 0.000000 1.000 1.000 19011180 19A Coriander, leaves 0.000000 1.000 1.000 19011181 19A Coriander, leaves
- babyfood 0.000000 1.000 1.000 19011440 19A Dillweed 0.000000 1.000 1.000 19011840 19A Herbs, other 0.000000 1.000 1.000 19011841 19A Herbs, other
- babyfood 0.000000 1.000 1.000 19012020 19A Lemongrass 0.000000 1.000 1.000 19012 200 19A Marjoram 0.000000 1.000 1.000 19012201 19A Marjoram
- babyfood 0.000000 1.000 1.000 19012490 19A Parsley, dried leaves 0.000000 1.000 1.000 19012491 19A Parsley, dried leaves
- babyfood 0.000000 1.000 1.000 19013340 19A Savory 0.000000 1.000 1.000 19021050 19B Cinnamon 0.000000 1.000 1.000 19021051 19B Cinnamon
- babyfood 0.000000 1.000 1.000 19021190 19B Coriander, seed 0.000000 1.000 1.000 19021191 19B Coriander, seed
- babyfood 0.000000 1.000 1.000 19021430 19B Dill, seed 0.000000 1.000 1.000 19022740 19B Pepper, b lack and white 0.000000 1.000 1.000 19022741 19B Pepper, black and white
- babyfood 0.000000 1.000 1.000 19023540 19B Spices, other 0.000000 1.000 1.000 19023541 19B Spices, other
- babyfood 0.000000 1.000 1.000 20001630 20 Flaxseed, oil 0.000000 1.000 1.000 20003190 20 Rapeseed, oil 0.340000 1.000 1.000 20003191 20 Rapeseed, oil
- bab yfood 0.340000 1.000 1.000 20003300 20 Safflower, oil 0.340000 1.000 1.000 20003301 20 Safflower, oil
- babyfood 0.340000 1.000 1.000 20003640 20 Sunflower, seed 0.140000 1. 000 1.000 20003650 20 Sunflower, oil 0.140000 1.000 1.000 20003651 20 Sunflower, oil
- babyfood 0.140000 1.000 1.000 21000440 M Beef, meat 0.035000 1.000 1.000 21000441 M Beef , meat - babyfood 0.035000 1.000 1.000 21000450 M Beef, meat, dried 0.035000 1.920 1.000 21000460 M Beef, meat byproducts 0.105000 1.000 1.000 21000461 M Beef, meat byproducts
- babyfood 0.105000 1.000 1.000 21000470 M Beef, fat 0.073000 1.000 1.000 21000471 M Beef,fat
- babyfood 0.073000 1.000 1.000 21000480 M Beef, kidney 0.105000 1.000 1.000 21000 490 M Beef, liver 0.105000 1.000 1.000 21000491 M Beef, liver
- babyfood 0.105000 1.000 1.000 23001690 M Goat, meat 0.035000 1.000 1.000 23001700 M Goat, meat byproducts 0.105000 1.000 1.000 23001710 M Goat, fat 0.073000 1.000 1.000 23001720 M Goat, kidney 0.105000 1.000 1.000 23001730 M Goat, liver 0.105000 1.000 1.000 24001890 M Horse, meat 0.000000 1.000 1.000 25002900 M Pork, meat 0.000000 1.000 1.000 25002901 M Pork, meat
- babyfood 0.000000 1.000 1.000 25002910 M Pork, ski n 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 22 of 26 25002920 M Pork, meat byproducts 0.000000 1.000 1.000 25002921 M Pork, meat byproducts
- babyfood 0.000000 1.000 1.000 25002930 M Pork, fat 0.000000 1.000 1.000 25002931 M Pork, fat
- babyfood 0.000000 1.000 1.000 25002940 M Pork, kidney 0.000000 1.000 1.000 25002950 M Pork, liver 0.000000 1.000 1.000 26003390 M Sheep, meat 0.035000 1.000 1.000 26003391 M Sheep, meat
- babyfood 0.035000 1.000 1.000 26003400 M Sheep, meat byproducts 0.105000 1. 000 1.000 26003410 M Sheep, fat 0.073000 1.000 1.000 26003411 M Sheep, fat
- babyfood 0.035000 1.000 1.000 26003420 M Sheep, kidney 0.105000 1.000 1.000 26003430 M Shee p, liver 0.105000 1.000 1.000 27002220 D Milk, fat 0.011000 1.000 1.000 27002221 D Milk, fat
- baby food/infant for 0.011000 1.000 1.000 27012230 D Milk, nonfat solids 0.011000 1.000 1.000 27012231 D Milk, nonfat solids
- baby food/in 0.011000 1.000 1.000 27022240 D Milk, water 0.011000 1.000 1.000 27022241 D Milk, water
- babyfood/infant form 0.011000 1.000 1.000 27032 251 D Milk, sugar (lactose)
- baby food/ 0.011000 1.000 1.000 28002210 M Meat, game 0.000000 1.000 1.000 29003120 M Rabbit, meat 0.000000 1.000 1.000 40000930 P Chicken, meat 0.000000 1.000 1.000 40000931 P Chicken, meat
- babyfood 0.000000 1.000 1.000 40000940 P Chicken, liver 0.000000 1.000 1.000 40000950 P Chicken, meat byproducts 0.000000 1.000 1.000 40000951 P Chicken, meat byproducts
- babyfoo 0.000000 1.000 1.000 40000960 P Chicken, fat 0.000000 1.000 1.000 40000961 P Chicken, fat
- babyfood 0.000000 1.000 1.000 40000970 P Chicken, skin 0.000000 1.000 1.000 40000971 P Chicken, skin
- babyfood 0.000000 1.000 1.000 50003820 P Turkey, meat 0.000000 1.000 1.000 50003821 P Turkey, meat
- baby food 0.000000 1.000 1.000 50003830 P Turkey, liver 0.000000 1.000 1.000 50003831 P Turkey, liver
- babyfood 0.000000 1.000 1.000 50003840 P Turkey, meat byproducts 0.000000 1. 000 1.000 50003841 P Turkey, meat byproducts
- babyfood 0.000000 1.000 1.000 50003850 P Turkey, fat 0.000000 1.000 1.000 50003851 P Turkey, fat
- babyfood 0.000000 1.000 1.000 50003860 P Turk ey, skin 0.000000 1.000 1.000 50003861 P Turkey, skin
- babyfood 0.000000 1.000 1.000 60003010 P Poultry, other, meat 0.000000 1.000 1.000 60003020 P Poultry, other, liver 0.000000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.000000 1.000 1.000 60003040 P Poultry, other, fat 0.000000 1.000 1.000 60003050 P Poultry, other, skin 0.000000 1.000 1.000 70001 450 P Egg, whole 0.004000 1.000 1.000 70001451 P Egg, whole
- babyfood 0.004000 1.000 1.000 70001460 P Egg, white 0.004000 1.000 1.000 70001461 P Egg, white (solids)
- ba byfood 0.004000 1.000 1.000 70001470 P Egg, yolk 0.004000 1.000 1.000 70001471 P Egg, yolk
- babyfood 0.004000 1.000 1.000 80001570 F Fish
- freshwater finfish 0.000000 1.000 1.000 80001580 F Fish
- freshwater finfish, farm ra 0.000000 1.000 1.000 80001590 F Fish
- saltwater finfish, tuna 0.000000 1.000 1.000 80001600 F Fish
- saltwater finfish, other 0.000000 1.000 1.000 80001610 F Fish
- shel lfish, crustacean 0.000000 1.000 1.000 80001620 F Fish
- shellfish, mollusc 0.000000 1.000 1.000 86010000 O Water, direct, all sources 0.006700 1.000 1.000 86011000 O Water, direct, tap 0.000000 1.000 1.000 86012000 O Water, direct, bottled 0.000000 1.000 1.000 86013000 O Water, direct, other 0.000000 1.000 1.000 86014000 O Water, direct, so urce - NS 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 23 of 26 86020000 O Water, indirect, all sources 0.006700 1.000 1.000 86021000 O Water, indirect, tap 0.000000 1.000 1.000 86022000 O Water, indirect, bottled 0.000000 1. 000 1.000 86023000 O Water, indirect, other 0.000000 1.000 1.000 86024000 O Water, indirect, source
- NS 0.000000 1.000 1.000 95000010 O Acerola 0.000000 1.000 1.000 95000060 O Amar anth, grain 0.000000 1.000 1.000 95000160 O Artichoke, globe 0.000000 1.000 1.000 95000190 O Asparagus 0.000000 1.000 1.000 95000200 O Avocado 0.000000 1.000 1.000 95000220 O Bamboo, shoots 0.000000 1.000 1.000 95000230 O Banana 0.000000 1.000 1.000 95000231 O Banana
- babyfood 0.000000 1.000 1.000 95000 240 O Banana, dried 0.000000 1.000 1.000 95000241 O Banana, dried
- babyfood 0.000000 1.000 1.000 95000540 O Belgium endive 0.000000 1.000 1.000 95000600 O Breadfruit 0.000000 1.000 1.000 95000730 O Cactus 0.000000 1.000 1.000 95000740 O Canistel 0.000000 1.000 1.000 95000770 O Carob 0.000000 1.000 1.000 95000890 O Cherimoya 0.000000 1.000 1.000 95001090 O Cocoa bean, chocolate 0.000000 1.000 1.000 95001100 O Cocoa bean, powder 0.000000 1.000 1.000 95001110 O Coconut, meat 0.000000 1.000 1.000 95001111 O Coconut
- meat - babyfood 0.000000 1.000 1.000 95001120 O Coconut, dried 0.000000 1.000 1.000 95001130 O Coconut, milk 0.000000 1.000 1.000 95001140 O Coconut, oil 0.000000 1.000 1.000 95001141 O Coconut, oil
- babyfood 0.000000 1.000 1.000 95001150 O Coffee, roasted b ean 0.000000 1.000 1.000 95001160 O Coffee, instant 0.000000 1.000 1.000 95001280 O Cottonseed, oil 0.010000 1.000 1.000 95001281 O Cottonseed, oil
- babyfood 0.010000 1. 000 1.000 95001300 O Cranberry 0.000000 1.000 1.000 95001301 O Cranberry
- babyfood 0.000000 1.000 1.000 95001310 O Cranberry, dried 0.000000 1.000 1.000 95001320 O Cran berry, juice 0.000000 1.000 1.000 95001321 O Cranberry, juice
- babyfood 0.000000 1.000 1.000 95001410 O Date 0.000000 1.000 1.000 95001510 O Feijoa 0.000000 1.000 1.000 95001530 O Fig 0.000000 1.000 1.000 95001540 O Fig, dried 0.000000 1.000 1.000 95001750 O Grape 0.000000 1.000 1.000 95001 760 O Grape, juice 0.000000 1.000 1.000 95001761 O Grape, juice
- babyfood 0.000000 1.000 1.000 95001770 O Grape, leaves 0.000000 1.000 1.000 95001780 O Grape, raisin 0.000000 1.000 1.000 95001790 O Grape, wine and sherry 0.000000 1.000 1.000 95001830 O Guava 0.000000 1.000 1.000 95001831 O Guava
- babyfood 0.000000 1.000 1.000 95001860 O Honey 0.000000 1.000 1.000 95001861 O Honey
- babyfood 0.000000 1.000 1.000 95001880 O Hop 0.000000 1.000 1.000 95001920 O Jaboticaba 0.000000 1.000 1.000 95001930 O Jackfruit 0.000000 1.000 1.000 95001950 O Kiwifruit 0.000000 1.000 1.000 95002090 O Longan 0.000000 1.000 1.000 95002110 O Lychee 0.000000 1.000 1.000 95002120 O Lychee, dried 0.000000 1.000 1.000 95002140 O Mamey apple 0.000000 1. 000 1.000 95002150 O Mango 0.000000 1.000 1.000 95002151 O Mango
- babyfood 0.000000 1.000 1.000 95002160 O Mango, dried 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 24 of 26 95002170 O Mang o, juice 0.000000 1.000 1.000 95002171 O Mango, juice
- babyfood 0.000000 1.000 1.000 95002180 O Maple, sugar 0.000000 1.000 1.000 95002190 O Maple syrup 0.000000 1.000 1.000 95002270 O Mulberry 0.000000 1.000 1.000 95002280 O Mushroom 0.000000 1.000 1.000 95002350 O Olive 0.000000 1.000 1.000 95002 360 O Olive, oil 0.000000 1.000 1.000 95002430 O Palm heart, leaves 0.000000 1.000 1.000 95002440 O Palm, oil 0.000000 1.000 1.000 95002441 O Palm, oil
- babyfood 0.000000 1.000 1.000 95002450 O Papaya 0.000000 1.000 1.000 95002451 O Papaya
- babyfood 0.000000 1.000 1.000 95002460 O Papaya, dried 0.000000 1.000 1.000 95002470 O Papaya, juice 0.000000 1.000 1.000 95002520 O Passionfruit 0.000000 1.000 1.000 95002521 O Passionfruit
- babyfood 0.000000 1.000 1.000 95002530 O Passionfr uit, juice 0.000000 1.000 1.000 95002531 O Passionfruit, juice
- babyfood 0.000000 1.000 1.000 95002540 O Pawpaw 0.000000 1.000 1.000 95002630 O Peanut 0.010000 1.000 1.000 95002640 O Peanut, butter 0.010000 1.000 1.000 95002650 O Peanut, oil 0.010000 2.000 1.000 95002750 O Peppermint 0.000000 1.000 1.000 95002760 O Peppermint, oil 0.000000 1.000 1.000 95002770 O Persimmon 0.000000 1.000 1.000 95002780 O Pine nut 0.000000 1. 000 1.000 95002790 O Pineapple 0.000000 1.000 1.000 95002791 O Pineapple
- babyfood 0.000000 1.000 1.000 95002800 O Pineapple, dried 0.000000 1.000 1.000 95002810 O Pine apple, juice 0.000000 1.000 1.000 95002811 O Pineapple, juice
- babyfood 0.000000 1.000 1.000 95002830 O Plantain 0.000000 1.000 1.000 95002840 O Plantain, dried 0.000000 1.000 1.000 95002890 O Pomegranate 0.000000 1.000 1.000 95003060 O Psyllium, seed 0.000000 1.000 1.000 95003110 O Quinoa, grain 0.000000 1.000 1.000 95003 330 O Sapote, Mamey 0.000000 1.000 1.000 95003350 O Seaweed 0.000000 1.000 1.000 95003351 O Seaweed
- babyfood 0.000000 1.000 1.000 95003360 O Sesame, seed 0.000000 1.000 1.000 95003361 O Sesame, seed
- babyfood 0.000000 1.000 1.000 95003370 O Sesame, oil 0.000000 1.000 1.000 95003371 O Sesame, oil
- babyfood 0.000000 1.000 1.000 95003460 O Soursop 0.000000 1.000 1.000 95003510 O Spanish lime 0.000000 1.000 1.000 95003520 O Spearmint 0.000000 1.000 1.000 95003530 O Spearmint , oil 0.000000 1.000 1.000 95003580 O Starfruit 0.000000 1.000 1.000 95003590 O Strawberry 0.000000 1.000 1.000 95003591 O Strawberry
- babyfood 0.000000 1.000 1.000 95003600 O Strawberry, juice 0.000000 1.000 1.000 95003601 O Strawberry, juice
- babyfood 0.000000 1.000 1.000 95003610 O Sugar apple 0.000000 1.000 1.000 95003620 O Sugarcane, sugar 0.000000 1.000 1.000 95003621 O Sugarcane, sugar
- babyfood 0.000000 1.000 1.000 95003630 O Sugarcane, molasses 0.000000 1. 000 1.000 95003631 O Sugarcane, molasses
- babyfood 0.000000 1.000 1.000 95003680 O Tamarind 0.000000 1.000 1.000 95003720 O Tea, dried 0.000000 1.000 1.000 95003730 O Tea, instant 0.000000 1.000 1.000 95003800 O Tomato, Tree 0.000000 1.000 1.000 95003900 O Vinegar 0.000000 1.000 1.000Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 25 of 26 95003970 O Water chestnut 0.000000 1.000 1.000 95003980 O Watercress 0.000000 1.000 1.000



### Attachment 3 Results of Acute DEEM
- FCID Dietary Exposure Anal ys is U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for FLUXAPYROXAD (1994
- 98 data) Residue file: 138009acute12
- 13
- 11.R98 Adjustment factor #2 NOT used. Analysis Date: 12
- 13
- 2011/11:57:31 Residue file dated: 12

- 13
- 2011/11:47:17/8 Daily totals for fo od and foodform consumption used. Run Comment: ""

=============================================================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population: 0.023310 1.86 0.048526 3.88 0.091981 7.36 All infants: 0.074082 5.93 0.106676 8.53 0.197221 15.78 Children 1
- 2 yrs: 0.068058 5.44 0.102022 8.16 0.161249 12.90 Children 3
- 5 yrs: 0.047241 3.78 0. 074577 5.97 0.142393 11.39 Children 6
- 12 yrs: 0.026755 2.14 0.041975 3.36 0.065099 5.21 Youth 13
- 19 yrs: 0.015850 1.27 0.030605 2.45 0.044312 3.54 Adults 20
- 49 yrs: 0.016730 1.34 0.027516 2.20 0.059303 4.74 Adults 50+ yrs: 0.013855 1.11 0.023064 1.85 0.043897 3.51 Females 13
- 49 yrs: 0.014264 1.14 0.023185 1.85 0.040718 3.26Fluxapyroxad (PC C ode 138009 ) Dietary Exposure and Risk Assessment DP # 390245



### Page 26 of 26 Attachment 4 Results of Chronic DEEM
- FCID Dietary Exposure Anal ys is U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for FLUXAPYROXAD (1994
- 98 data) Residue file name: F: \ Fluxapyroxad \ 138009chronic12
- 13
- 11HAFT.R98 Adjustment factor #2 NOT used. Analysis Date 12
- 13
- 2011/11:49:02 Residue file dated: 12

- 13
- 2011/11:45:33/8 Reference dose (RfD, Chronic) = .021 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.002923 13.9% U.S. Population (spring season) 0.002899 13.8% U.S. P opulation (summer season) 0.002990 14.2% U.S. Population (autumn season) 0.002920 13.9% U.S. Population (winter season) 0.002880 13.7% Northeast region 0.003114 14.8% Midwest region 0.002831 13.5% Southern region 0.002639 12.6% Western region 0.003301 15.7% Hispanics 0.003521 16.8% Non - hispanic whites 0.002734 13.0% Non - hispanic blacks 0.002810 13.4% Non - hisp/non

- white/non

- black 0.004920 23.4% All infants (< 1 year) 0.008474 40.4% Nursing infants 0.004882 23.2% Non - nursing infants 0.009838 46.8% Children 1
- 6 yrs 0.007991 38.1% Children 7
- 12 yrs 0.003701 17.6% Females 13
- 19 (not preg or nursing) 0.002021 9.6% Females 20+ (not preg or nursing) 0.001931 9.2% Females 13
- 50 yrs 0.002201 10.5% Females 13+ (preg/not nursing) 0.002613 12.4% Females 13+ (nursing) 0.002602 12.4% Males 13
- 19 yrs 0.002396 11.4% Males 20+ yrs 0.002330 11.1% Seniors 55+ 0.002001 9.5% Children 1
- 2 yrs 0.010055 47.9% Children 3
- 5 yrs 0.007369 35.1% Children 6
- 12 yrs 0.004011 19.1% Youth 13
- 19 yrs 0.0022 17 10.6% Adults 20
- 49 yrs 0.002204 10.5% Adults 50+ yrs 0.002007 9.6% Females 13
- 49 yrs 0.001986 9.5%

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