Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION

MEMORANDUM

DATE: 11/7/2014

SUBJECT: Metconazole Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Section 3 Registration Actions on Pea 

and Bean, Dried Shelled, except Soybean, Subgroup 6C and the Sunflower 

Subgroup 20B; Expansion of the Canola Tolerance to the Rapeseed Subgroup 

20A; and Conversion of the Established Stone Fruit and Tree Nut Crop Groups 

to the Stone Fruit Group 12-12 and the Tree Nut Group 14-12.

FROM: Nancy Dodd, Chemist

Risk Assessment Branch III (RAB3)

Health Effects Division (HED; 7509P)

THROUGH: Mohsen Sahafeyan, Chemist

Seyed Tadayon, Chemist

Dietary Exposure Science Advisory Council (DESAC)

TO: Barry O’Keefe, Risk Assessor

RAB3/HED (7509P)

and

Barbara Madden, PM #05

Minor Use and Emergency Response Branch

Registration Division (RD; 7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and 

PC Code: 125619 DP Number: D423622

Decision No.: 487580 Registration No.: 59639-147

Petition No.: 4E8244 Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Exposure Case No.: NA

TXR No.: NA CAS No.: 125116-23-6

MRID No.: NA 40 CFR: §180.617
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Nutrition Examination Survey, What We Eat in America (NHANES/WWEIA). The analyses 

were conducted in support of a human-health risk assessment for the proposed Section 3 uses 

of metconazole on the pea and bean, dried shelled, except soybean, subgroup 6C and the 

sunflower subgroup 20B; expansion of the canola tolerance to the rapeseed subgroup 20A; and 

conversion of the established stone fruit and tree nut crop groups to the stone fruit group 12-12 

and the tree nut group 14-12. This memorandum was reviewed by two peer reviewers of the 

DESAC, per DESAC SOP 2012.1. 

Acute Dietary (Food and Drinking Water) Exposure Assessment

An unrefined acute dietary (food and drinking water) exposure assessment was conducted.

The residue levels used in the assessment were the established or recommended tolerance 

levels except for cereal grains and livestock commodities. Since cereal grains and livestock 

commodities include metabolites as residues of concern in the risk assessment, maximum 

residue values for the metabolites from field trials were added to the metconazole tolerance 

levels. DEEM default processing factors or empirical processing factors were used, as 

available. It was assumed that 100% of the crops were treated. 

The estimated drinking water concentration (EDWC) used in the acute dietary assessment was

provided by the Environmental Fate and Effects Division (EFED) and incorporated directly 

into the acute assessment. The groundwater EDWC of 51.8 ug/L (ppb) generated by the 

PRZM-Ground Water (PRZM-GW) model was used in the acute dietary assessment. The 

highest application rate, which was the application rate for turf, was modeled using the WI 

Central Sand Scenario in estimating metconazole EDWCs for groundwater. 

The acute dietary (food and drinking water) exposure to metconazole is below HED’s level of 

concern for females 13-49 years old, the only population subgroup of concern. For the general 

U.S. population, including infants and children, an appropriate dose/endpoint attributable to a 

single dose was not observed in the available oral toxicity studies. The acute dietary exposure 

estimate at the 95th percentile is 4.6% of the aPAD for females 13-49 years old, the only

population subgroup of concern.

Chronic Dietary (Food and Drinking Water) Exposure Assessment

An unrefined chronic dietary (food and drinking water) exposure assessment was conducted.

The residue levels used in the assessment were the established or recommended tolerance 

levels except for cereal grains and livestock commodities. Since cereal grains and livestock 

commodities include metabolites as residues of concern in the risk assessment, maximum 

residue values for the metabolites from field trials were added to the metconazole tolerance 

levels. DEEM default processing factors or empirical processing factors were used, as 

available. It was assumed that 100% of the crops were treated. 

The EDWC used in the chronic dietary assessment was provided by EFED and incorporated 

directly into the chronic assessment. The surface water EDWC of 43.9 ug/L (ppb) generated 

by the Surface Water Concentration Calculator (SWCC) model was used in the chronic dietary

assessment. The SWCC model was used to generate EDWCs for the Tier II aquatic exposure 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

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assessment based on the cranberry scenario. The SWCC is a graphical user interface that runs 

the Pesticide Root Zone Model (PRZM, v 5, November 15, 2006) and the Variable Volume 

Water Body Model (VVWM, 3/6/2014) (USEPA, 2006b). The default percent cropped area 

(PCA) factor of 1.0 was used.

The chronic dietary (food and drinking water) exposure to metconazole is below HED’s level 

of concern for the general U.S. population and all population subgroups. The chronic dietary

exposure estimates are 6.6% of the cPAD for the general U.S. population and 14% of the 

cPAD for children 1-2 years old, the most highly exposed population subgroup.

Cancer Exposure Results and Characterization

Metconazole was classified as “not likely to be carcinogenic to humans;” therefore, a cancer 

dietary assessment was not performed. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 

(8/20/1999).

The most recent dietary risk assessment for metconazole was conducted by Amelia Acierto 

(3/28/2011, D387504).

II. Residue Information

Residues of Concern: The residues of concern for the tolerance expression and risk assessment 

(DP# 348234, C. Olinger, 2/11/2008) are summarized in Table 1 below.

The triazole metabolites (1,2,4-triazole, triazolylalanine, and triazolylacetic acid) are also 

residues of concern, but they are addressed in a separate dietary exposure assessment document 

(DP# 414951, T. Morton, 10/24/13).
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Table 1. Summary of Metabolites and Degradates to be included in the Risk Assessment 

and Tolerance Expression1,2

Matrix Residues Included In Risk 

Assessment

Residues Included In 

Tolerance Expression

Plants Primary and Rotational 

Crops, except Cereal Grains

Metconazole Metconazole

Primary and Rotational 

Crops, Cereal Grains only

Metconazole and M11 Metconazole

Livestock

Metconazole; M1 and its 

glucuronic acid conjugate; M12; 

M31 and its glucuronic acid 

conjugate

Metconazole

Drinking Water Metconazole Not Applicable

1 For all triazole-containing pesticides, 1,2,4-triazole, triazolylalanine (TA), and triazolylacetic acid (TAA) should 

also be included as residues of concern for risk assessment purposes only for plant and livestock commodities. 

Since these metabolites are common to the entire class of triazole-derivative fungicides and because of 

differential toxicity between the metabolites and the various parent compounds, risks associated with exposure 

to 1,2,4-T and to TA/TAA are addressed in separate risk assessment documents.

2 M1 = 5-[(4-chlorophenyl)methyl]-2-methoxyl-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyclopentanol; M11 

= 5-[(4-chlorophenyl)methoxyl]-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyclopentanol; M12 = 5-[(4-

chlorophenyl)methyl]-2-carboxyl-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyclopentanol; M31 = 

(1S*,3R*,5S*)-3-hydroxy-cis-metconazole; 1,2,4-T = 1H-1,2,4-triazole; TAA = 1H-1,2,4-triazol-1-yl acetic 

acid; TA = 2-amino-3-(1H-1,2,4-triazol-1-yl)propanoic acid.

Established Tolerances: Tolerances are established under 40 CFR §180.617 for residues of 

metconazole, including its metabolites and degradates, on a variety of raw agricultural 

commodities. Compliance with the tolerance levels is to be determined by measuring only

metconazole as the sum of its cis- and trans-isomers. Permanent tolerances have been 

established for a variety of raw agricultural and processed commodities. Time-limited 

tolerances, set to expire on 12/31/14, have also been established on sugarcane cane and 

molasses.

Recommended Tolerances: In PP#4E8244 (as shown in Table 2 below), the Interregional 

Research Project No. 4 (IR-4), on behalf of the IR-4 Project and the Agricultural Experiment 

Stations of Montana, South Dakota, North Dakota, and Colorado (dry bean), Montana, South 

Dakota, Idaho, and North Dakota (dry pea), and Kansas, Montana, South Dakota and North 

Dakota (sunflower), requested the establishment of permanent tolerances and registration for 

use on the pea and bean, dried shelled, except soybean, subgroup 6C, and the sunflower 

subgroup 20B; expansion of the canola tolerance to the rapeseed subgroup 20A; and 

conversion of the established stone fruit crop group 12 and tree nut crop group 14 to the stone 

fruit crop group 12-12 and the tree nut crop group 14-12. 
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Table 2. Recommended Metconazole Tolerances for PP#4E8244.

Commodity HED-Recommended 

Tolerances (ppm)

Pea and bean, dried shelled, except soybean, subgroup 6C 0.15

Sunflower subgroup 20B 0.7

Rapeseed subgroup 20A 0.08

Fruit, stone, group 12-12 0.2

Nut, tree, group 14-12 0.04

Residue Values Used in This Assessment: The residue levels used in the assessment are the 

established or recommended tolerance levels except for cereal grains and livestock 

commodities. Since cereal grains and livestock commodities include metabolites as residues of 

concern in the risk assessment, maximum residue values for the metabolites from field trials 

were added to the metconazole tolerance levels. Residue values used for cereal grains and 

livestock commodities are shown in Table 3 below:

Table 3. Residue Values Used in DEEM for Cereal Grains and Livestock 

Commodities

Commodities HED Recommended 

Tolerances - Parent only 

(ppm)

Maximum Residue 

Level For 

Metabolites (ppm, 

parent equivalents)

Residue Values Used 

in DEEM (ppm)1

Corn, field, grain 0.02 M11 (0.01) 0.03

Corn, pop, grain 0.02 M11 (0.01) 0.03

Corn, sweet, kernel plus cob 

with husk removed

0.01 M11 (0.01) 0.02

Small 

grains

Barley, grain 2.5 M11 (0.33) 2.83

Oat, grain 1.0 M11 (0.34) 1.34

Rye, grain 0.25 M11 (0.04) 0.29

Wheat, grain 0.15 M11 (0.03) 0.18

Cattle, meat byproducts 0.04 M1 (0.02)

M12 (0.02)

M31 (0.02)

0.10

Goat, meat byproducts

Horse, meat byproducts

Sheep, meat byproducts

Egg 0.04 M1 (0.02)

M12 (0.02)

M31 (0.02)

0.10

1 For cereal grains and livestock commodities, the residue values used in the DEEM include the sum of parent

(tolerance) and metabolite(s), reported as parent equivalents. Residues in meat byproducts and eggs are <LOQ 

(<0.02 ppm for each analyte).

. 

Processing Factors: DEEM default processing factors were used for apricot, dried (6.0x), 

banana/plantain, dried (3.9x), cherry juice (1.5x), corn, field, syrup (1.5x), cranberry juice 

(1.1x), peach, dried (7.0x), peanut butter (1.89x), and plum, prune, juice (1.4x).

Empirical processing factors, based on processing studies, were used for the bran of barley, 

oat, and wheat (2.0x), wheat flour (1x), wheat germ (1x), soybean oil (1x), sugarcane, sugar 

(1x) (all D348168, N. Dodd, 2/20/08; processing factors for barley, oat and wheat commodities 
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include residues of parent and metabolite M11 from MRID 46902231); potato commodities 

(potato, chips; potato, dry) (1x) (D380990, A. Acierto, 3/24/11); rapeseed oil/sesame oil (1x) 

(D419223, N. Dodd, 11/4/14), and sunflower oil (1x) (D419223, N. Dodd, 11/4/14). (The 

processing factor of 1x was used for processing factors which were ≤1x.) A separate tolerance

was established for sugarcane molasses under a Section 18 (D341748, B. O’Keefe, 8/15/08);

therefore, the processing factor was set to 1. Separate tolerances were established for peanut 

oil and sugar beet molasses; therefore, the processing factors were set to 1 (D348168, N. Dodd, 

2/20/08). Although concentration was observed in dried prune (2.3x), it was determined that 

the tolerance for the raw agricultural commodity is adequate to cover the residues in the

processed commodity (D348168, N. Dodd, 2/20/08); therefore, the processing factor for dried 

prune is set to 1.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 

2009, and 2010; however, the samples were not analyzed for metconazole. As a result, 

residues in fish were not included in the assessment.

III. Percent Crop Treated

100% crop treated (100% CT) was assumed for all commodities.

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Drinking 

Water Exposure Assessment for the Section 3 New Use of Metconazole on Pea and Bean 

(Dried Shelled, Subgroup 6C), and Sunflower (Subgroup 20B)” (D418674, Faruque Khan, 

Ph.D., 9/30/14) and incorporated directly into this dietary assessment. Water residues were 

incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and 

“water, indirect, all sources.” 

Metconazole parent is the only residue of concern considered in the drinking water assessment. 

No degradates of metconazole were included based on the recommendation from the Residues 

of Concern Knowledgebase Subcommittee (ROCKS) of HED (USEPA, 2008, D348234). 

For surface water, the Surface Water Concentration Calculator (SWCC v 1.106) model was 

used to generate EDWCs for the Tier II aquatic exposure assessment based on cranberry use.

The SWCC is a graphical user interface that runs the Pesticide Root Zone Model (PRZM, v 5, 

November 15, 2006) and the Variable Volume Water Body Model (VVWM, 3/6/2014) 

(USEPA, 2006b). The default percent cropped area (PCA) factor of 1.0 was used.

For peak exposure and annual mean exposure, lower EDWCs for surface water were generated 

using the Tier II Pesticide Root Zone Model and Exposure Analysis Modeling System (PRZMEXAMS), based on metconazole use on PA turf with a PCA factor of 1. The use on turf 

reflected the highest application rate (i.e., five applications at 0.6 lb ai/A/application with a 14-

day retreatment interval). The modeled EDWCs for pea/bean (dried shelled) and sunflower did 

not exceed the concentrations from PA turf. 
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For groundwater, the PRZM-Ground Water (PRZM-GW) model was used to estimate EDWCs. 

The highest application rate, which was the application rate for turf, was modeled in estimating 

metconazole EDWCs for groundwater. Since application rates for proposed uses are lower 

than turf, no additional PRZM-GW modeling was conducted.

The EDWCs used in HED’s human health dietary risk assessment are bolded in summary

Table 4 below. The groundwater EDWC of 51.8 ug/L (ppb) was used in the acute dietary

assessment. The surface water EDWC of 43.9 ug/L (ppb) was used in the chronic dietary

assessment.

Table 4. Recommended EDWCs for the Proposed Uses of Metconazole for Drinking 

Water Sources1

Drinking Water 

Source Crop Scenario (Model)

Peak 

Exposure

(Acute)

(μg/L)

Annual Mean 

Exposure 

(Non-Cancer 

Chronic)

(μg/L)

30-year Mean 

Exposure 

(Cancer 

Chronic)

(μg/L) 

Surface Water Turf 245.5 31.3 22.8

Cranberry349.6 43.9 NA5

Groundwater WI Central Sand Scenario4

51.8 NA5

20.0

1 Bolded values are the recommended EDWCs for assessing acute and chronic dietary exposures from metconazole 

uses.

2 The Tier II model PRZM/EXAMS was used to generate EDWCs for surface water, based on metconazole use on 

PA turf. A percent cropped area (PCA) factor of 1 was used.

3 The SWCC v 1.106 model was used to generate EDWCs for the Tier II aquatic exposure assessment. The SWCC 

is a graphical user interface that runs the Pesticide Root Zone Model (PRZM, v 5, November 15, 2006) and the 

Variable Volume Water Body Model (VVWM, 3/6/2014) (USEPA, 2006b). The default PCA factor of 1.0 was 

used.

4 The Tier 1 PRZM-GW model was used to reassess groundwater EDWCs for the turf use, which has the highest 

application rate (5 applications at of 0.6 lbs ai/A/application).

5 Not applicable.

The drinking water models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCID Program and Consumption Information

Metconazole acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups. 

However, for acute exposure assessment, consumption data are retained as individual 

consumption events. Based on analysis of the 2003-2008 WWEIA consumption data, which 
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took into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. population, 

all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, 

females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake 

estimate. The resulting residue intake estimate for each food/food form is summed with the 

residue intake estimates for all other food/food forms on the commodity residue list to arrive at 

the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as 

a percent of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure 

for a deterministic exposure assessment, or “matched” in multiple random pairings with 

residue values and then summed in a probabilistic assessment. The resulting distribution of 

exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who 

reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported 

eating the relevant commodities as well as those who did not) basis. In accordance with HED 

policy, per capita exposure and risk are reported for analyses performed at all levels of 

refinement. However, for deterministic assessments, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment.

VI. Toxicological Information

The risk assessment team selected endpoints or confirmed endpoints that were selected 

previously. The Cancer Assessment Review Committee (CARC) for metconazole met on 

November 2, 2005 (memo, Gregory Akerman, Ph.D., TXR# 0054211, 4/14/06). The 

Metconazole Endpoint Selection meeting was held on December 21, 2005. The Toxicity

Advisory Clinic (TAC) met on 1/10/06 to discuss the acute hazard endpoint selection and the 

FQPA selection. 

The critical studies in which HED has high confidence suggest a low (or no) level of concern 

for pup susceptibility. Other data in which HED has a lower level of confidence suggests some 

level of concern for pup susceptibility. Taken together, there is low concern (and thus low 

uncertainty) that the young are more susceptible than adults to metconazole exposures. Thus, 

the FQPA factor has been removed (i.e., reduced to 1X). 

A summary of toxicological endpoints for use in human health risk assessment is presented 

below in Table 5:
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Table 5. Summary of Toxicological Doses and Endpoints for Metconazole for Use in 

Dietary and Non-Occupational Human Health Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQP

A Safety Factors

RfD, PAD, Level 

of Concern for 

Risk Assessment

Study and Toxicological 

Effects

Acute Dietary 

(General 

Population, 

including Infants 

and Children)

An appropriate dose/endpoint attributable to a single dose was not observed in the 

available oral toxicity studies.

Acute Dietary

(Females 13-49 

years of age)

NOAEL= 12 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1x

Acute RfD = 0.12 

mg/kg/day

aPAD= 0.12 

mg/kg/day

Developmental toxicity in 

rats: LOAEL= 30 

mg/kg/day based on 

increases in skeletal 

variations (predominantly

lumbar ribs).

Chronic Dietary 

(All Populations)

NOAEL= 4.3 

mg/kg/day

UFA=10x

UFH= 10x

FQPA SF= 1x

Chronic RfD = 

0.04 mg/kg/day

cPAD = 0.04 

mg/kg/day

Chronic oral toxicity 

study in rats: LOAEL = 

13.1 mg/kg/day based on 

increased liver (M) weights 

and associated 

hepatocellular lipid 

vacuolation (M) and 

centrilobular 

hypertrophy(M). Same 

effects seen in F at 54 

mg/kg/day, plus increased 

spleen wt.

Cancer (oral, 

dermal, inhalation)

Classification: “Not likely to be Carcinogenic to Humans” based on convincing 

evidence that carcinogenic effects are not likely below a defined dose range. A nongenotoxic mode of action for mouse liver tumors was established. No quantification is 

required.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity

among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted

dose (a = acute, c = chronic). 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure and risk 

of the U.S. population and various population subgroups. The results reported in Table 6 are 

for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-

12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years old.

Results of Acute Dietary (Food and Drinking Water) Exposure and Risk Analysis

The results of the acute dietary (food and drinking water) exposure and risk analysis at the 95th

percentile of exposure are reported in Table 6, below. The acute assessment was performed for 
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females 13-49 years old only, since an acute endpoint was not identified for the general U.S.

population. The acute dietary (food and drinking water) exposure is 4.6% of the aPAD for 

females 13-49.

Results of Chronic Dietary (Food and Drinking Water) Exposure and Risk Analysis

The results of the chronic dietary (food and drinking water) exposure and risk analysis are 

reported in Table 6, below. The chronic dietary (food and drinking water) exposure to 

metconazole is below HED’s level of concern for the general U.S. population and all 

population subgroups. The chronic dietary (food and drinking water) exposure estimates are 

6.6% of the cPAD for the general U.S. population and 14% of the cPAD for children 1-2 years 

old, the most highly exposed population subgroup. 

Table 6. Summary of Dietary (Food and Drinking Water) Exposure and Risk for 

Metconazole.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

NA NA

0.002653 6.6

N/A N/A

All Infants (<1 year old) 0.004963 12

Children 1-2 years old* 0.005391 14

Children 3-5 years old 0.004749 12

Children 6-12 years old 0.003241 8.1

Youth 13-19 years old 0.002045 5.1

Adults 20-49 years old 0.002549 6.4

Adults 50-99 years old 0.002166 5.4

Females 13-49 years old* 0.005500 4.6 0.002179 5.4

*The subpopulations with the highest risk estimates are bolded.

VIII. Characterization of Inputs/Outputs

Unrefined acute and chronic dietary exposure assessments were conducted. Except for cereal 

grains and livestock commodities, the residue levels used in the assessment were the 

established or recommended tolerance levels. For cereal grains and livestock commodities, 

maximum residue values for the metabolites from field trials were added to the metconazole 

tolerance levels. It was assumed that 100% of the crops were treated. Default and empirical 

processing factors were used, as available. EDWCs based on modeling were provided by 

EFED and incorporated directly into the acute and chronic dietary assessments. Although not 

needed at this time, HED could refine the exposure and risk estimates with the following 

information: 1) projected market share/percent crop treated data; 2) anticipated residue data; 

and 3) monitoring data.
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IX. Conclusions

Acute and chronic dietary (food and drinking water) exposure assessments were conducted for 

the proposed/established uses. The acute dietary (food and drinking water) exposure to 

metconazole is below HED’s level of concern for females 13-49 years old, the only population 

subgroup of concern. The chronic dietary (food and drinking water) exposure to metconazole 

is below HED’s level of concern for the general U.S. population and all population subgroups.

X. List of Attachments

1. Acute Food plus Water Residue Input File.

2. Acute Results File.

3. Chronic Food plus Water Residue Input File.

4. Chronic Results File.
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Attachment 1. Acute Food plus Water Residue Input File

Filename: C:\Users\ndodd\Documents\DEEM Version 3.16\Metconazole\MetconazoleAcuteSunflower.R08

Chemical: Metconazole

RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4.3 mg/kg bw/day

RfD(Acute): .12 mg/kg bw/day NOEL(Acute): 12 mg/kg bw/day

Date created/last modified: 11-07-2014/15:57:58 Program ver. 3.16, 03-08-d

Comment: 

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.070000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.070000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 D34816

 Full comment: D348168

0101053001 1A Beet, sugar, molasses-babyfood 0.080000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.040000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000 

0103082000 1CD Cassava 0.040000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.040000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.040000 1.000 1.000 

0103166000 1CD Ginger 0.040000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.040000 1.000 1.000 

0103167000 1CD Ginger, dried 0.040000 1.000 1.000 

0103296000 1C Potato, chips 0.040000 1.000 1.000 D38099

 Full comment: D380990

0103297000 1C Potato, dry (granules/ flakes) 0.040000 1.000 1.000 D38099

 Full comment: D380990

0103297001 1C Potato, dry (granules/ flakes)-b 0.040000 1.000 1.000 

0103298000 1C Potato, flour 0.040000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.040000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.040000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.040000 1.000 1.000 

0103366000 1CD Sweet potato 0.040000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.040000 1.000 1.000 

0103371000 1CD Tanier, corm 0.040000 1.000 1.000 

0103387000 1CD Turmeric 0.040000 1.000 1.000 

0103406000 1CD Yam, true 0.040000 1.000 1.000 

0103407000 1CD Yam bean 0.040000 1.000 1.000 

0600347000 6 Soybean, seed 0.050000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 

0600350000 6 Soybean, oil 0.050000 1.000 1.000 D34816

 Full comment: D348168

0600350001 6 Soybean, oil-babyfood 0.050000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.050000 1.000 1.000 

0603030000 6C Bean, black, seed 0.150000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.150000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.150000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.150000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.150000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.150000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.150000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.150000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.150000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.150000 1.000 1.000 

0603098000 6C Chickpea, seed 0.150000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.150000 1.000 1.000 

0603099000 6C Chickpea, flour 0.150000 1.000 1.000 

0603182000 6C Guar, seed 0.150000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.150000 1.000 1.000 

0603203000 6C Lentil, seed 0.150000 1.000 1.000 

0603256000 6C Pea, dry 0.150000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.150000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.150000 1.000 1.000 

0603348000 6C Soybean, flour 0.050000 1.000 1.000 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 13 of 19

0603348001 6C Soybean, flour-babyfood 0.050000 1.000 1.000 

1201090000 12A Cherry 0.200000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.200000 1.000 1.000 

1201091000 12A Cherry, juice 0.200000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.200000 1.500 1.000 

1202012000 12B Apricot 0.200000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.200000 1.000 1.000 

1202013000 12B Apricot, dried 0.200000 6.000 1.000 

1202014000 12B Apricot, juice 0.200000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.200000 1.000 1.000 

1202230000 12B Nectarine 0.200000 1.000 1.000 

1202260000 12B Peach 0.200000 1.000 1.000 

1202260001 12B Peach-babyfood 0.200000 1.000 1.000 

1202261000 12B Peach, dried 0.200000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.200000 7.000 1.000 

1202262000 12B Peach, juice 0.200000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.200000 1.000 1.000 

1203285000 12C Plum 0.200000 1.000 1.000 

1203285001 12C Plum-babyfood 0.200000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.200000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.200000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.200000 1.000 1.000 D34816

 Full comment: D348168

1203287001 12C Plum, prune, dried-babyfood 0.200000 1.000 1.000 

1203288000 12C Plum, prune, juice 0.200000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.200000 1.400 1.000 

1302057000 13B Blueberry 0.400000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.400000 1.000 1.000 

1302136000 13B Currant 0.400000 1.000 1.000 

1302137000 13B Currant, dried 0.400000 1.000 1.000 

1302149000 13B Elderberry 0.400000 1.000 1.000 

1302174000 13B Gooseberry 0.400000 1.000 1.000 

1302191000 13B Huckleberry 0.400000 1.000 1.000 

1307130000 13G Cranberry 0.400000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.400000 1.000 1.000 

1307131000 13G Cranberry, dried 0.400000 1.000 1.000 

1307132000 13G Cranberry, juice 0.400000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.400000 1.100 1.000 

1400003000 14 Almond 0.040000 1.000 1.000 

1400003001 14 Almond-babyfood 0.040000 1.000 1.000 

1400004000 14 Almond, oil 0.040000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.040000 1.000 1.000 

1400059000 14 Brazil nut 0.040000 1.000 1.000 

1400068000 14 Butternut 0.040000 1.000 1.000 

1400081000 14 Cashew 0.040000 1.000 1.000 

1400092000 14 Chestnut 0.040000 1.000 1.000 

1400155000 14 Hazelnut 0.040000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 

1400185000 14 Hickory nut 0.040000 1.000 1.000 

1400213000 14 Macadamia nut 0.040000 1.000 1.000 

1400269000 14 Pecan 0.040000 1.000 1.000 

1400278000 14 Pine nut 0.040000 1.000 1.000 

1400282000 14 Pistachio 0.040000 1.000 1.000 

1400391000 14 Walnut 0.040000 1.000 1.000 

1500025000 15 Barley, pearled barley 2.830000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 2.830000 1.000 1.000 

1500026000 15 Barley, flour 2.830000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 2.830000 1.000 1.000 

1500027000 15 Barley, bran 2.830000 2.000 1.000 

1500120000 15 Corn, field, flour 0.030000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.030000 1.000 1.000 

1500121000 15 Corn, field, meal 0.030000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.030000 1.000 1.000 

1500122000 15 Corn, field, bran 0.030000 1.000 1.000 

1500123000 15 Corn, field, starch 0.030000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.030000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.030000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.030000 1.500 1.000 

1500125000 15 Corn, field, oil 0.030000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.030000 1.000 1.000 

1500126000 15 Corn, pop 0.030000 1.000 1.000 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 14 of 19

1500127000 15 Corn, sweet 0.020000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.020000 1.000 1.000 

1500231000 15 Oat, bran 1.340000 2.000 1.000 

1500232000 15 Oat, flour 1.340000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 1.340000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 1.340000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 1.340000 1.000 1.000 

1500328000 15 Rye, grain 0.290000 1.000 1.000 

1500329000 15 Rye, flour 0.290000 1.000 1.000 

1500401000 15 Wheat, grain 0.180000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.180000 1.000 1.000 

1500402000 15 Wheat, flour 0.180000 1.000 1.000 D34816

 Full comment: D348168

1500402001 15 Wheat, flour-babyfood 0.180000 1.000 1.000 

1500403000 15 Wheat, germ 0.180000 1.000 1.000 D34816

 Full comment: D348168

1500404000 15 Wheat, bran 0.180000 2.000 1.000 D34816

 Full comment: D348168, MRID 46902231

2001163000 20A Flax seed, oil 0.080000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.080000 1.000 1.000 D42362

 Full comment: D423622

2001319001 20A Rapeseed, oil-babyfood 0.080000 1.000 1.000 

2001336000 20A Sesame, seed 0.080000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.080000 1.000 1.000 

2001337000 20A Sesame, oil 0.080000 1.000 1.000 D42362

 Full comment: D423622

2001337001 20A Sesame, oil-babyfood 0.080000 1.000 1.000 

2002330000 20B Safflower, oil 0.700000 1.000 1.000 

2002330001 20B Safflower, oil-babyfood 0.700000 1.000 1.000 

2002364000 20B Sunflower, seed 0.700000 1.000 1.000 

2002365000 20B Sunflower, oil 0.700000 1.000 1.000 D42362

 Full comment: D423622

2002365001 20B Sunflower, oil-babyfood 0.700000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.250000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.250000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.100000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.100000 1.000 1.000 

3100049000 31 Beef, liver 0.100000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.100000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.100000 1.000 1.000 

3200173000 32 Goat, liver 0.100000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.100000 1.000 1.000 

3500343000 35 Sheep, liver 0.100000 1.000 1.000 

7000145000 70 Egg, whole 0.100000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.100000 1.000 1.000 

7000146000 70 Egg, white 0.100000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.100000 1.000 1.000 

7000147000 70 Egg, yolk 0.100000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.100000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.051800 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.051800 1.000 1.000 

9500023000 O Banana 0.100000 1.000 1.000 

9500023001 O Banana-babyfood 0.100000 1.000 1.000 

9500024000 O Banana, dried 0.100000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.100000 3.900 1.000 

9500263000 O Peanut 0.040000 1.000 1.000 

9500264000 O Peanut, butter 0.050000 1.890 1.000 

9500265000 O Peanut, oil 0.050000 1.000 1.000 D34816

 Full comment: D348168

9500283000 O Plantain 0.100000 1.000 1.000 

9500284000 O Plantain, dried 0.100000 3.900 1.000 

9500362000 O Sugarcane, sugar 1.600000 1.000 1.000 D34816

 Full comment: D348168

9500362001 O Sugarcane, sugar-babyfood 1.600000 1.000 1.000 

9500363000 O Sugarcane, molasses 3.200000 1.000 1.000 Sectio

 Full comment: Section 18 tolerance =1.6 x 2x 

9500363001 O Sugarcane, molasses-babyfood 3.200000 1.000 1.000 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 15 of 19

Attachment 2. Acute Results File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for METCONAZOLE NHANES 2003-2008 2-Day

Residue file: MetconazoleAcuteSunflower.R08 Adjustment factor #2 used.

Analysis Date: 11-07-2014/16:13:21 Residue file dated: 11-07-2014/15:57:58

NOEL (Acute) = 12.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: " "

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

 0.005500 4.58 2181 0.008947 7.46 1341 0.015703 13.09 764 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 16 of 19

Attachment 3. Chronic Food plus Water Residue Input File

Filename: C:\Users\ndodd\Documents\DEEM Version 

3.16\Metconazole\MetconazoleChronicSunflower.R08

Chemical: Metconazole

RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4.3 mg/kg bw/day

RfD(Acute): .12 mg/kg bw/day NOEL(Acute): 12 mg/kg bw/day

Date created/last modified: 11-07-2014/15:59:15 Program ver. 3.16, 03-08-d

Comment: 

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.070000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.070000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.080000 1.000 1.000 D34816

 Full comment: D348168

0101053001 1A Beet, sugar, molasses-babyfood 0.080000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.040000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000 

0103082000 1CD Cassava 0.040000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.040000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.040000 1.000 1.000 

0103166000 1CD Ginger 0.040000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.040000 1.000 1.000 

0103167000 1CD Ginger, dried 0.040000 1.000 1.000 

0103296000 1C Potato, chips 0.040000 1.000 1.000 D38099

 Full comment: D380990

0103297000 1C Potato, dry (granules/ flakes) 0.040000 1.000 1.000 D38099

 Full comment: D380990

0103297001 1C Potato, dry (granules/ flakes)-b 0.040000 1.000 1.000 

0103298000 1C Potato, flour 0.040000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.040000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.040000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.040000 1.000 1.000 

0103366000 1CD Sweet potato 0.040000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.040000 1.000 1.000 

0103371000 1CD Tanier, corm 0.040000 1.000 1.000 

0103387000 1CD Turmeric 0.040000 1.000 1.000 

0103406000 1CD Yam, true 0.040000 1.000 1.000 

0103407000 1CD Yam bean 0.040000 1.000 1.000 

0600347000 6 Soybean, seed 0.050000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 

0600350000 6 Soybean, oil 0.050000 1.000 1.000 D34816

 Full comment: D348168

0600350001 6 Soybean, oil-babyfood 0.050000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.050000 1.000 1.000 

0603030000 6C Bean, black, seed 0.150000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.150000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.150000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.150000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.150000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.150000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.150000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.150000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.150000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.150000 1.000 1.000 

0603098000 6C Chickpea, seed 0.150000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.150000 1.000 1.000 

0603099000 6C Chickpea, flour 0.150000 1.000 1.000 

0603182000 6C Guar, seed 0.150000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.150000 1.000 1.000 

0603203000 6C Lentil, seed 0.150000 1.000 1.000 

0603256000 6C Pea, dry 0.150000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.150000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.150000 1.000 1.000 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 17 of 19

0603348000 6C Soybean, flour 0.050000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.050000 1.000 1.000 

1201090000 12A Cherry 0.200000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.200000 1.000 1.000 

1201091000 12A Cherry, juice 0.200000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.200000 1.500 1.000 

1202012000 12B Apricot 0.200000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.200000 1.000 1.000 

1202013000 12B Apricot, dried 0.200000 6.000 1.000 

1202014000 12B Apricot, juice 0.200000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.200000 1.000 1.000 

1202230000 12B Nectarine 0.200000 1.000 1.000 

1202260000 12B Peach 0.200000 1.000 1.000 

1202260001 12B Peach-babyfood 0.200000 1.000 1.000 

1202261000 12B Peach, dried 0.200000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.200000 7.000 1.000 

1202262000 12B Peach, juice 0.200000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.200000 1.000 1.000 

1203285000 12C Plum 0.200000 1.000 1.000 

1203285001 12C Plum-babyfood 0.200000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.200000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.200000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.200000 1.000 1.000 D34816

 Full comment: D348168

1203287001 12C Plum, prune, dried-babyfood 0.200000 1.000 1.000 

1203288000 12C Plum, prune, juice 0.200000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.200000 1.400 1.000 

1302057000 13B Blueberry 0.400000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.400000 1.000 1.000 

1302136000 13B Currant 0.400000 1.000 1.000 

1302137000 13B Currant, dried 0.400000 1.000 1.000 

1302149000 13B Elderberry 0.400000 1.000 1.000 

1302174000 13B Gooseberry 0.400000 1.000 1.000 

1302191000 13B Huckleberry 0.400000 1.000 1.000 

1307130000 13G Cranberry 0.400000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.400000 1.000 1.000 

1307131000 13G Cranberry, dried 0.400000 1.000 1.000 

1307132000 13G Cranberry, juice 0.400000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.400000 1.100 1.000 

1400003000 14 Almond 0.040000 1.000 1.000 

1400003001 14 Almond-babyfood 0.040000 1.000 1.000 

1400004000 14 Almond, oil 0.040000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.040000 1.000 1.000 

1400059000 14 Brazil nut 0.040000 1.000 1.000 

1400068000 14 Butternut 0.040000 1.000 1.000 

1400081000 14 Cashew 0.040000 1.000 1.000 

1400092000 14 Chestnut 0.040000 1.000 1.000 

1400155000 14 Hazelnut 0.040000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 

1400185000 14 Hickory nut 0.040000 1.000 1.000 

1400213000 14 Macadamia nut 0.040000 1.000 1.000 

1400269000 14 Pecan 0.040000 1.000 1.000 

1400278000 14 Pine nut 0.040000 1.000 1.000 

1400282000 14 Pistachio 0.040000 1.000 1.000 

1400391000 14 Walnut 0.040000 1.000 1.000 

1500025000 15 Barley, pearled barley 2.830000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 2.830000 1.000 1.000 

1500026000 15 Barley, flour 2.830000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 2.830000 1.000 1.000 

1500027000 15 Barley, bran 2.830000 2.000 1.000 

1500120000 15 Corn, field, flour 0.030000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.030000 1.000 1.000 

1500121000 15 Corn, field, meal 0.030000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.030000 1.000 1.000 

1500122000 15 Corn, field, bran 0.030000 1.000 1.000 

1500123000 15 Corn, field, starch 0.030000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.030000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.030000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.030000 1.500 1.000 

1500125000 15 Corn, field, oil 0.030000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.030000 1.000 1.000 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 18 of 19

1500126000 15 Corn, pop 0.030000 1.000 1.000 

1500127000 15 Corn, sweet 0.020000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.020000 1.000 1.000 

1500231000 15 Oat, bran 1.340000 2.000 1.000 

1500232000 15 Oat, flour 1.340000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 1.340000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 1.340000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 1.340000 1.000 1.000 

1500328000 15 Rye, grain 0.290000 1.000 1.000 

1500329000 15 Rye, flour 0.290000 1.000 1.000 

1500401000 15 Wheat, grain 0.180000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.180000 1.000 1.000 

1500402000 15 Wheat, flour 0.180000 1.000 1.000 D34816

 Full comment: D348168

1500402001 15 Wheat, flour-babyfood 0.180000 1.000 1.000 

1500403000 15 Wheat, germ 0.180000 1.000 1.000 D34816

 Full comment: D348168

1500404000 15 Wheat, bran 0.180000 2.000 1.000 D34816

 Full comment: D348168; MRID 46902231

2001163000 20A Flax seed, oil 0.080000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.080000 1.000 1.000 D42362

 Full comment: D423622

2001319001 20A Rapeseed, oil-babyfood 0.080000 1.000 1.000 

2001336000 20A Sesame, seed 0.080000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.080000 1.000 1.000 

2001337000 20A Sesame, oil 0.080000 1.000 1.000 D42362

 Full comment: D423622

2001337001 20A Sesame, oil-babyfood 0.080000 1.000 1.000 

2002330000 20B Safflower, oil 0.700000 1.000 1.000 

2002330001 20B Safflower, oil-babyfood 0.700000 1.000 1.000 

2002364000 20B Sunflower, seed 0.700000 1.000 1.000 

2002365000 20B Sunflower, oil 0.700000 1.000 1.000 D42362

 Full comment: D423622

2002365001 20B Sunflower, oil-babyfood 0.700000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.250000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.250000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.100000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.100000 1.000 1.000 

3100049000 31 Beef, liver 0.100000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.100000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.100000 1.000 1.000 

3200173000 32 Goat, liver 0.100000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.100000 1.000 1.000 

3500343000 35 Sheep, liver 0.100000 1.000 1.000 

7000145000 70 Egg, whole 0.100000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.100000 1.000 1.000 

7000146000 70 Egg, white 0.100000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.100000 1.000 1.000 

7000147000 70 Egg, yolk 0.100000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.100000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.043900 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.043900 1.000 1.000 

9500023000 O Banana 0.100000 1.000 1.000 

9500023001 O Banana-babyfood 0.100000 1.000 1.000 

9500024000 O Banana, dried 0.100000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.100000 3.900 1.000 

9500263000 O Peanut 0.040000 1.000 1.000 

9500264000 O Peanut, butter 0.050000 1.890 1.000 

9500265000 O Peanut, oil 0.050000 1.000 1.000 D34816

 Full comment: D348168

9500283000 O Plantain 0.100000 1.000 1.000 

9500284000 O Plantain, dried 0.100000 3.900 1.000 

9500362000 O Sugarcane, sugar 1.600000 1.000 1.000 D34816

 Full comment: D348168

9500362001 O Sugarcane, sugar-babyfood 1.600000 1.000 1.000 

9500363000 O Sugarcane, molasses 3.200000 1.000 1.000 Sectio

 Full comment: Section 18 tolerance =1.6 x 2x 

9500363001 O Sugarcane, molasses-babyfood 3.200000 1.000 1.000 
Metconazole Dietary-Exposure and Risk Assessment DP Number: D423622 

__________________________________________________________________________________________

Page 19 of 19

Attachment 4: Chronic Results File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for METCONAZOLE NHANES 2003-2008 2-day

Residue file name: C:\Users\ndodd\Documents\DEEM Version 

3.16\Metconazole\MetconazoleChronicSunflower.R08

 Adjustment factor #2 used.

Analysis Date 11-07-2014/16:15:22 Residue file dated: 11-07-2014/15:59:15

Reference dose (RfD, Chronic) = .04 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.002653 6.6%

Hispanic 0.002641 6.6%

Non-Hisp-White 0.002701 6.8%

Non-Hisp-Black 0.002353 5.9%

Non-Hisp-Other 0.002747 6.9%

Nursing Infants 0.002351 5.9%

Non-Nursing Infants 0.006129 15.3%

Female 13+ PREG 0.002123 5.3%

Children 1-6 0.004914 12.3%

Children 7-12 0.003045 7.6%

Male 13-19 0.002133 5.3%

Female 13-19/NP 0.001966 4.9%

Male 20+ 0.002658 6.6%

Female 20+/NP 0.002149 5.4%

Seniors 55+ 0.002074 5.2%

All Infants 0.004963 12.4%

Female 13-50 0.002174 5.4%

Children 1-2 0.005391 13.5%

Children 3-5 0.004749 11.9%

Children 6-12 0.003241 8.1%

Youth 13-19 0.002045 5.1%

Adults 20-49 0.002549 6.4%

Adults 50-99 0.002166 5.4%

Female 13-49 0.002179 5.4%

-------------------------------------------------------------------------------