Exhibit 31.1

                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

     I, Christopher A. Marlett, Chief Executive Officer of Integrated Surgical
Systems, Inc., certify that:

     1.   I have reviewed this Quarterly Report on Form 10-Q for the quarter
          ended September 30, 2009 of Integrated Surgical Systems, Inc. (the
          "registrant");

     2.   Based on my knowledge, this report does not contain any untrue
          statement of a material fact or omit to state a material fact
          necessary to make the statements made, in light of the circumstances
          under which such statements were made, not misleading with respect to
          the period covered by this Quarterly Report;

     3.   Based on my knowledge, the financial statements, and other financial
          information included in this report, fairly present in all material
          respects the financial condition, results of operations and cash flows
          of the registrant as of, and for, the periods presented in this
          Quarterly Report;

     4.   The registrant's other certifying officers and I are responsible for
          establishing and maintaining disclosure controls and procedures (as
          defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
          control over financial reporting (as defined in Exchange Act Rules
          13a-15(f) and 15d-15(f)) for the registrant and have:

          (a) Designed such disclosure controls and procedures, or caused such
          disclosure controls and procedures to be designed under our
          supervision, to ensure that material information relating to the
          registrant, including its consolidated subsidiaries, is made known to
          me by others within those entities, particularly during the period in
          which this Quarterly Report is being prepared;

          (b) Designed such internal control over financial reporting or caused
          such internal control over financial reporting to be designed under
          our supervision, to provide reasonable assurance regarding the
          reliability of financial reporting and the preparation of financial
          statements for external purposes in accordance with generally accepted
          accounting principles;

          (c) Evaluated the effectiveness of the registrant's disclosure
          controls and procedures and presented in this Quarterly Report, my
          conclusions about the effectiveness of the disclosure controls and
          procedures, as of the end of the period covered by this Quarterly
          Report based on such evaluation; and

          (d) Disclosed in this Quarterly Report any change in the registrant's
          internal control over financial reporting that occurred during the
          registrant's most recent fiscal quarter (the registrant's fourth
          fiscal quarter in the case of an annual report) that has materially
          affected, or is reasonably likely to materially affect, the
          registrant's internal control over financial reporting.

     5.   The registrant's other certifying officer(s) and I have disclosed,
          based on our most recent evaluation of internal control over financial
          reporting, to the registrant's auditors and the audit committee of the
          registrant's board of directors (or persons performing the equivalent
          functions); (a) All significant deficiencies and material weaknesses
          in the design or operation of internal control over financial
          reporting which are reasonably likely to adversely affect the
          registrant's ability to record, process, summarize and report
          financial information; and (b) Any fraud, whether or not material,
          that involves management or other employees who have a significant
          role in the registrant's internal control over financial reporting.


         Dated:  November 10, 2009          By: /s/   Christopher A. Marlett
                                                      -----------------------
                                                      Christopher A. Marlett
                                                      Chief Executive Officer