### SAT Report PMN Number: P-12-0406 SAT Date: 6/29/2012 Print Date: 4/1/2014

Related cases :

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 2 3

Persistence Bioaccum Toxicity Comments 3 12

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ;

P 2 Rec Comments : Comment: P2REC: SAT: SAT recommends not sending this forward.

Keywords : Keywords: DEVEL, THYMUS, LIVER, SPLEEN, BLOOD, LUNG, IRR, AQUATOX-A,C
Summary of Assessment :

Fate : Fate Summary: P-12-0406 FATE: Estimations for neutralized anion log Kow = 3.13 (E) log Koc = 2.95 (E) log Fish BCF = 1.73 (E)log Fish BAF = 2.04 (E) PMN Substance: Solid S = Disp. VP < 1.0E-6 torr at 25 C (E) BP > 400 C (E) H < 1.00E-8 (E) POTW removal (%) = 0 via possible partial biodeg Time for complete ultimate aerobic biodeg > mo Sorption to soils/sediments = low PBT Potential: P3B1 *CEB FATE: Migration to ground water = rapid

Health : Health Summary: Absorption is nil through the skin as the neat material, moderate through the skin when in solution, and good through the lungs and GI tract based on p hysical/chemical properties. There is concern for lung effects if inhaled and irritation based on the surfactant properties of the PMN material. There is concern for liver and thymus effects and developmental toxicity based on the submitted study for an analog with a paternal NOEL = 10 mg/kg and a developmental NOEL = 50 mg /kg. There is also conceren for blood and spleen toxicity based on data submitted for an unidentified analogue with a LOAEL of 15 mg/kg. Test Data: P-12-0406: rat oral LD0 = 2500 mg/kg; a series of one-dose 28-day oral studies were conducted with compounds that may or may not be analogues of the PMN substance (test substances were identified by code number only), the lowest LOAEL for these compounds was 15 mg/kg with effects to the blood, liver, and spleen

negative in Salmonella and E coli with and without activation oral absorption /metabolism study in rats - serum half-life is approximately 6 hours (males only) corrosive to the rabbit eye mild skin irritant in rabbits not a dermal sensitizer in guinea pigs, Magnusson and Kligman acute oral study in rats - 2 of 6 died at 2000 mg/kg, lethargy, ventro-lateral recumbency, hunched p osture, uncoordinated movements, flat gait, shallow respiration, p iloerection, salivation

negative for induction of chromosome aberrations in cultured human lymphocytes with and without activation oral combined repeated dose toxicity study with reproduction/developmental screening toxicity test in rats (10, 50, 250 mg/kg) - salivation, p erioral substance and urine-stained abdominal fur at 250 mg/kg; reduced body weight gain and feed consumption at 50 and 250 mg/kg, microscopic changes in liver at 50 and 250 mg/kg; microscopic changes in thymus at 250 mg/kg; no effects on FOB and motor activity; no reproductive effects; reduced number of liveborn pups and increase in stillborn pups at 250 mg/kg; reduced viability of pups and reduced pup weights at250 mg/kg; p aternal NOEL = 10 mg/kg; developmental NOEL = 50 mg/kg oral absorption/metabolism study in rats (males and females only) - analytic phase of study not completed due to problems with the animals no skin irritation in rabbits oral absorption/metabolism study in rats (male and female) - halflife in serum = 17 hours slight eye irritant in rabbits not a dermal sensitizer in guinea pigs, Magnusson and Kligman acute oral study in rats - no deaths at 2000 mg/kg, lethargy, uncoordinated movements, hunched p osture, chromodacryorrhea

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 ≥ 1.0 daphnid 48-h LC50 ≥ 1.0 green algal 96-h EC50 ≥ 1.0 fish

_ chronic value ≥ 0.10 daphnid

_ chronic value ≥ 0.10

algal

_ chronic value ≥ 0.10

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for anionic surfactants and sulfonamides, and uncertainty; SAR chemical class = surfactant-anionic ; MW 316; effective concentrations based on 100% active ingredients and nominal concentrations ; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 10

SARs anionic surfactants SAR Class surfactant-anionic Ecotox Category Anionic Surfactants

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916