## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Pa ge 3 of 32 the parent compound only. For water , the highest estimate from conservative models was used for both the acute and the chronic dietary exposure analyses.

Based on these highly conservative assumptions, acute dietary (food and water) risk estimates at

the 95 th 

## percentile of exposure are les s than or equal to 9. 4 % of the acute population

- adjusted dose (aPAD) for all population subgroups. Chronic dietary (food and water) risk estimates are less than or equal to 4 4 % of the chronic population

- adjusted dose (cPAD) for all population subgroups. Generally, HED is concerned when risk estimates exceed 100% of the PAD; therefore, all acute and chronic dietary risk estimates are below HED’s level of concern (LOC).

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the populati on adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety

factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

1999).

The most recent dietary risk assessment for thiamethoxam was conducted by Dennis McNeilly ( D392489

, 29 Sept 2011 ).



## II. Residue Information

Tolerances have been established for both thiamethoxam (40CFR §180.565) and clothianidin (40CFR §180.586) on a variety of commodities. These analyses were performed to support the

Section 3 request for an increased tolerance for thiamethoxam residues in/o n imported coffee

. Thiamethoxam is used to treat various agricultural crops, turf grass, sod farms, golf course s
, residential lawns, indoor residential area ( crack and crevice treatment ) , ornamental plants grown in greenhouses, and Christmas tree farm s. Tolerances are established for residues of thiamethoxam and its metabolites and degradates in or on numerous food and feed commodities. Tolerances range from 0.02 ppm in several commodities to 4.5 ppm in head and stem Brassica (subgroup 5A). The residue of concern for this dietary risk assessment is thiamethoxan and its metabolite, clothianidin.

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Pa ge 4 of 32 As discussed above, thiamethoxam’s major metabolite is CGA

- 322704, which is also the registered active ingredient clothianidin. Clothianidin has a complete toxi cological database and appears to have effects in mammals that are different from those of thiamethoxam. Prior to receipt of the complete toxicity database for clothianidin, the Agency assumed, based on structural similarity, that the toxicity profile for clothianidin was equivalent to that of thiamethoxam, and conducted risk assessments on the combined thiamethoxam and clothianidin residues. The complete database has demonstrated that clothianidin does not have the same toxicity profile

, and residues of clothianidin need not be added to residues of thiamethoxam and compared to the thiamethoxam endpoints for risk assessment. Instead separate dietary exposure and risk assessments should be conducted for thiamethoxam and clothianidin. However, given

the co mplexity of previous assessments with combined residues , the Agency is continuing to

include residues of clothianidin from thiamethoxam uses in the thiamethoxam risk assessment recognizing that this is an overestimate of risk.

Table 1. HED

- Recommend ed Food Tolerance for Thiamethoxam’s Use in/on Imported

C offee Beans

. Commodity Proposed Tolerance (ppm) Recommended

Tolerance (ppm) Comments; Correct

Commodity Definition

Tolerances Proposed under 180.565(a)

C offee 0. 20 0.2 0 Coffee, bean, green 1



### Note: The current tolerance for coffee, bean , green is 0.05 ppm

. 1

– There are no US registrations as of Nov 15, 2012

.



## Acute Assessment

The acute assessment is based on tolerance level residues of thiamethoxam/clothianidin (the tolerance is for combined residues). The drinking water estimate for the acute analysis provided

in Table 2 (and explained in Table 3) includes residues of thiamet hoxam from thiamethoxam uses, and is discussed in Section IV below. A complete listing of the residues and processing

factors used in the acute analys i s is included in Attachment 1.

Chronic Assessment

All of the inputs, except for the increased tolerance for coffee, are derived from HED’s Sept 29

, 20 11 review for thiamethoxam ( D3 92489 , Dennis McNeilly )

. The HED

- recommended tolerance

level for coffee is used (0.2 0 ppm) . The drinking water estimate for the chronic analysis provided in Table 2 (and explained in Table 3) includes residues of thiamethoxam from thiamethoxam uses, and is discussed in Section IV below. Tolerance level (4.0 ppm) was used for leaf lettuce for both the acute and chronic analyses

. A complete listing of the residues and processing factors used in the chronic analys i s is in Attachment 3

.

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Pa ge 5 of 32 The chronic assessment makes use of tolerance level residues, average residue values or the highest observed residue value from the thiamethoxam field trials. Anticipated residues were evaluated for selected commodities only, which were listed in HED’s dietary analyses for thiamethoxam ( D3 92489 , D. McNeilly, 29 Sept 20 1 1 ). Although monitoring data are available for some commodities, field trial r esidues were used for all the uses, along with a high

- end

estimate of residues in drinking water. Therefore this assessment is considered to be highly

conservative.

For the purpose of determining an FHE anticipated residue, the FHE tolerance of 0.02 was divided by a factor of 2 (ChemSAC Database, Policy Issues Addressed (Updated 2/27/98), 2_POLICY.TBL.doc). As a result, a residue value of 0.01 ppm was used for all commodities for

which tolerances have not been established.

Processing factors

Empirical processing factors were used when available. For food forms without empirical processing factors, DEEM 7.81 default values were used. A complete listing of the empirical processing factors used can be found in Table 2 below. Note: Processing factors ar e not used for residues reflecting the use in food handling establishments. Use of processing factors would not be appropriate for this case since the processed commodities would likely be treated after processing.

Livestock

HED continues to conclude that residues in eggs and poultry meat, fat, and meat byproducts remain a 40CFR §180.6[a][3] situation (there is no expectation of finite residues in these commodities). As a result, tolerances are still not required in any poultry commodities

.

The dietary burden for cattle and /or swine have not increased significantly from those previously calculated. Therefore, the current tolerances in livestock commodities are still appropriate

, and the residue estimates for livestock commodities are as recommended in the previous thiamethoxam risk assessment ( D3 92489 , D. McNeilly, 29 Sept 20 11 ).

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Pa ge 6 of 32 TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES

.

RAC Blending

Classification Data

Source No. of

Samples No. of

Detectable

Residues LOD or

LOQ

(Avg. in PPM) Reference Processing Factors (PF) 1 Anticipated Residue Estimates/Tolerance

Chronic (Tol., AR) 2

Artic hoke, globe NB/PB FT 6 6 0.02 D281702/

D325447 N/A 0.19

Barley, grain B FT 16 10 0.02 D281702/

D325447

(PF Ref

- D281702) 0.3 pearled

0.3 bran

0.1 flour 0.086

Brassica , head and stem, subgroup 5

- A NB/PB FT (cabbage) 12 10 0.02 D281702/

D325447 N/A 0.98

Brassica , leafy greens, subgroup 5

- B NB/PB FT

(mustard greens) 10 10 0.02 D281702/

D325447 N/A 0.82

Caneberry subgroup

13

- A PB FT 12 12 0.02 D281702/

D325447 N/A 0.12

Cereal Grains, Group 15

(except barley and rice) B Tol. NA NA NA D391723 NA 0.02

Coffee B Tol. NA NA NA D 402441 NA 0.20

Citrus, fruits:

Orange

Grapefruit

Lemon NB/PB FT 28

16

12 27

16

12 0.02 D349272 0.6 oil

0.6 juice 0.10

0.07

0.09

Food Handling

Establishments NA FT 42

42 18 3

8 0.02 D376367 NA 0.01

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Pa ge 7 of 32 TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES

.

RAC Blending

Classification Data

Source No. of

Samples No. of

Detectable

Residues LOD or

LOQ

(Avg. in PPM) Reference Processing Factors (PF) 1 Anticipated Residue Estimates/Tolerance

Chronic (Tol., AR) 2

Fruit, pome, group 11 NB/PB FT (apple)

FT (pear) 26

12 26

10 0.02 D281702/

D325447

& D265079 0.75 juice 0.06

0.06

Fruit, stone, group 12

Cherry

Peach (apricots/nectarines)

Plum PB

NB/PB

NB/PB FT

FT

FT 20

20

20 20

19

8 0.02 W. Cutchin,

12/10/03 DERs

1 prunes 0.21

0.07

0.071

Grape PB FT 24 22 0.02 D281702/

D325447 1.1 juice 0.06

Grape, raisin PB FT (grape) 24 22 0.02 D281702/

D325447

PF

– D281702 2.3 0.06

Leaf Lettuce

/Crop Group 4 NB Tol. NA NA 0.02 D281702 /

D343521 NA 4.0

Peanut B FT 54 10 0.02 D376367 0.31 oil 0.05

Rice B FT 32 1 0.02 D357449/

D357450

PF

– D357449 0.9 po lished

rice and rice

bran 0.01

Soybeans B FT 30 0 0.02 D281702/

D325447 N/A 0.01

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Pa ge 8 of 32 TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES

.

RAC Blending

Classification Data

Source No. of

Samples No. of

Detectable

Residues LOD or

LOQ

(Avg. in PPM) Reference Processing Factors (PF) 1 Anticipated Residue Estimates/Tolerance

Chronic (Tol., AR) 2

Spearmint oil B N/A N/A N/A N/A D281702/

D325447 0.05X

(translated

from the mint study)

Tree Nuts , group 14 PB FT 12 0 0.02 D349272 N/A 0.01

Tropical Fruits NB FT (avocado) 10 2 0.02 D357449/

D357450 N/A 0.11

Vegetable, fruiting, ’

group 8

Tomato

Pepper NB/PB FT 40

42 -

42 0.02

0.02 D281702/

D325447 +

D265079

PF

– D265079 Tomato puree

1.7

Tomato paste

3.8 0.08

0.08

Vegetable, legume, group

6 B/PB FT

Snap beans

Lima beans 16

10 0

0 0.02 S. Ta d ayon,

26 Nov 2002 N/A 0.01

0.01

Vegetable, root, subgroup

1 C NB/PB Tolerance N/A D357449/

D357450 Potato chips

1.2

Potato flakes

1.7 0.05

Water (direct, indirect) N/A EFED N/A N/A N/A N/A N/A Acute= 0.13177 ppm Chronic= 0.01131 ppm

1

- The processing factors for existing uses are taken from HED’s 

## 29 Sept 20 11 memo, the sources for these processing factors are cited in the
reference column. An average processing of 0.31 for peanut oil is the only new processing factor associated with the propos ed new uses.

2

- Anticipated residues were calculated us ing 1⁄2 LOQ for all values below the LOQ.

3

- Separate analyses were conducted and reported for thiamethoxam and clothianidin. Each compound has an LOQ of 0.01 ppm, with a combined LOQ of 0.02 ppm

## Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 9 of 32 The USDA Pesticide Data Program (PDP) monit ored pesticide residues in catfish in 2008, 2009,

and 2010. Over this 3

- year period, PDP analyzed 1479 samples of catfish for thiamethoxam residues. None of the samples contained detectable residues. As a result, residues in fish were

not included in th e assessment.

I I I. Percent Crop Treated Information

Percent crop treated information was not used in either the acute or chronic analysis.

IV. Drinking Water Data

The drinking water residues used in these dietary risk assessments were provided by EFED ( D391528, C. Koper, 28 July 2011; and D3 73378 , C. Koper, 2 0 May 2010), and incorporated directly into the dietary assessments. Water residues were incorporated in DEEM

- FCID via entry into the food categories “water, direct, all sources” and “water, indirect, all sources.” Clothianidin, a major metabolite of thiamethoxam in plants and livestock, is not a significant degradate of thiamethoxam in surface or groundwater sources of drinking water.

For surface water, the EDWCs for the crops evaluated/ modeled in this assessment did not exceed the EDWCs for rice reported in the p revious drinking water assessment (D363202 , F. Khan, 07 April 2009 ) . The reported acute concentration of 131.77 μg/L, annual mean (chronic) concentration of 11.31 μg/L

, and the highest 30 year annual average concentration of 11.31 μg/L

from the rice model are higher than the reported EDWCs for various uses in Table 3

. Therefore,

the current EDWCs for surface water do not supersede the drinking water concentrations previously estimated for this chemical (D363202)

. For groundwater, based on the proposed high est annual use rate for dry bulb onions (0.3 lbs ai/acre) , the SCI

- GROW model concentration of thiamethoxam is 4.66 μg/L . This value is the recommended EDWC for groundwater.

Typically, HED uses the higher of the surface or groundwater estimates for each d uration when assessing dietary risk. For thiamethoxam, the results from the rice model are the highest estimates for each duration and were used in the dietary assessments.

The model s and their description s are available at the EPA internet website via the web link, http://www.epa.gov/oppefed1/models/water/

.

Table 3. Tier II Estimated Drinking Water Concentrations (EDWCs) resulting from applications of Thiamethoxam.

Drinking Water

Source (model) Use

Scenario (modeled rate) 1

- in

- 10 year

acute ( μg/L ) 1

- in

- 10 year

chronic ( μg/L ) 30

- year

average ( μg/L )

Tail water (Rice Model) Rice

(0.173 lbs ai/A/year) 131.77 1,2 

## 11.31 1,3 

## 11.31 1,3



## Cranberry (0.188 lbs ai/A/year) 54.75 2 

## 4.50 3 

## 4.50 3

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 10 of 32 Table 3. Tier II Estimated Drinking Water Concentrations (EDWCs) resulting from applications of Thiamethoxam.

Drinking Water

Source (model) Use

Scenario (modeled rate) 1

- in

- 10 year

acute ( μg/L ) 1

- in

- 10 year

chronic ( μg/L ) 30

- year

average ( μg/L )

Groundwater (SCI

- GROW) Dry bulb onions:

(1 app. X 0.30 lbs. ai/acre) 4.66 4.66 4.66

Bold text denotes maximum estimated EDWC values. All values adjusted with PCA factor of

0.87.

1. R ecommended EDWCs for surface water. 2. EDWCs based on day 1. 3. EWDCs based on average of 365 days.



## Water Monitoring Data

Only very limited monitoring data are available for thiamethoxam and these data are discussed below; due to this limitation HED used modeling data for the drinking water residue estimate for both the acute and chronic dietary risk assessments.

Two small

- scale prospective groundwater (PGW) monitoring studies were initiated in southwest Michigan in June 2001 and southwestern Ge orgia in the spring of 2002, to determine the potential for the active ingredient thiamethoxam and its degradates to reach groundwater when used in a vulnerable hydrogeologic setting. Analytical data were collected fo r 47 months (from

treatme nt in the spring of 2001 until May 2005) in the Michigan study and fo r 36 months (from treatment in the spring of 2002 until May 2005) in the Georgia study

.

In Michigan, thiamethoxam residues found in soil

- pore water samples have clearly peaked and

then declined. N o quantifiable residues of thiamethoxam > LOQ (0.05 ppb) were observed in any of the 3, 6, and 9

- ft lysimeters after the 36, 16, and 41

- MAT sampling events, respectively. By

the 47

- MAT sampling event

, only trace level detections of thiamethoxam were obser ved in three

of the 15

- ft. lysimeter units ( maximum concentration 0.11 ppb ).

In Georgia, thiamethoxam residues have only been confirmed in four shallow monitoring wells (MW

- 1S, MW

- 3S, MW

- 5S, and MW

- 8S) during 47 months of sampling. Thiamethoxam

residues i n groundwater peaked at 43

- MAT, and by 47

- MAT residues were confined to two shallow monitoring wells only ( maximum concentration 0.12 ppb ). No detections of thiamethoxam at or greater than the analytical method LOQ have been observed in any groundwater sam ples collected from the deep monitoring wells during 47 months of sampling.

V. DEEM

- FCID Program and Consumption Information

Thiamethoxam acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database

DEEM

- FCID, Version 3.16 , which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individ uals over two non

- consecutive survey

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 11 of 32 days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available r ecipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups . However , for acute exposure assessment

, consumption data are

ret ained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgr oups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in e ach food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each fo od/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This proc edure is performed for each population subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue p oint estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposure s is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for a nalyses performed at all levels of refinement . However, for

deterministic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and not ed in the risk assessment.

VI. Toxicological Information

The toxicology database for thiamethoxam is complete. The scientific quality is relatively high and the toxicity profile of thiamethoxam can be characterized for most effects, including potential carcinogenic, mutagenic, developmental, and neurotoxic effects.

The Agency has determined that the 10X FQPA safety factor for the protection of infants and children can be reduced to 1X. There is no quantitative or qualitative evidence of increased susceptibility of rat or rabbit fetuses to in utero exposure to thiame thoxam in the developmental toxicity studies. The developmental NOAELs are either higher than or equal to the maternal NOAELs. The Developmental Neurotoxity (DNT) Workgroup concluded there was no evidence of increased quantitative susceptibility in the D NT study in rats, based on evaluation of additional brain morphometric data for the low

- and mid

- dose pups (January 17, 2007 meeting).

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 12 of 32 Although there is evidence of increased quantitative susceptibility for male pups of both two generation reproductive studies, NOAELs and LOAELs were established in these studies, and the Agency selected the NOAEL for testicular effects in F1 pups as the basis for risk assessment. The Agency is confident that the NOAEL selected for risk assessment is protective of the m ost sensitive effect (testicular effects) for the most sensitive subgroup (pups) observed in the toxicological database.

In addition, the NOAELs selected for risk assessment are protective of all toxicological effects

observed in the database includi ng treatment

- related changes in the adrenal gland, thyroid, testes and ovaries. Thus, the Agency believes the FQPA safety factor can be reduced to 1X and still be conservatively protective of human health risk.

Table 4. Toxicological Doses and Endpoin ts for Thiamethoxam for Use in Human Health

Risk Assessments. Exposure/

Scenario Point of

Departure Uncertainty/

FQPA Safety

Factors Level of

Concern for

Risk

Assessment Study and Toxicological

Effects

Acute Dietary All populations including

infants and

children NOAEL =

34.5 mg/kg/day UF A 

### = 10x

UF H 

### = 10x

SF FQPA 

### =1 aRfD=0.35

mg/kg/day

aPAD=0.35 mg/kg/day Rat Developmental Neurotoxicity

study LOAEL = 298.7 mg/kg/day based on delayed sexual maturation in male pups, and reduced brain morphometric measurements.

Chronic Dietary All populations including

infants and

children NOAEL= 1.2

mg/kg/day UF A 

### = 10x

UF H 

### = 10x

SF FQPA 

### =1 cRfD=0.012

mg/kg/day

cPAD=0.012 mg/kg/day 2

- Generation reproduction study

in Rats LOAEL = 1.8 mg/kg/day based on increased incidence and severity of tubular atrophy in testes of F1 generation males.

2

- Generation reproduction study in Rats (46402904)
LOAEL = 3 (males), not determined (females) mg/kg/day based on sperm abnormalities in F1 males.

Cancer (oral, dermal, inhalation) “Not Likely to be Carcinogenic to Humans” based on convincing evidence that a non

genotoxic mode of action for liver tumors was established in the mouse and that the carcinogenic effects are a result of a mode of action dependent on suf ficient amounts of a hepatotoxic metabolite produced persistently. Quantification of cancer risk is not required.



## VII. Results/Discussion

The DEEM

- FCIDTM analyses estimate the dietary exposure of the US population and various population subgroups. The results of the assessments are shown in Table 5, below.

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 13 of 32 Table 5. Summary of Estimated Dietary (Food + Drinking Water) Exposures and Risk for

Thiamethoxam.

Population Subgroup aPAD,

mg/kg/day Acute Estimates (95 th



## Percentile) 1 

## cPAD,

mg/kg/day Chronic Estimates

Exposure, mg/kg/day Risk,

% aPAD Exposure, mg/kg/day Risk,

% cPAD

U.S. Population 0.35 0.017192 4.9 0.012 0.002663 22
All infants (< 1 year) 2 

### 0.35 0.027915 8.0 0.012 0.002560 21

Children 1

- 2 yrs 0.35 0.0 32993 9.4 0.012 0.005286 44

Children 3

- 5 yrs 0.35 0.0 27008 7.7 0.012 0.004446 37

Children 6

- 12 yrs 0.35 0.017406 5.0 0.012 0.002767 23

Youth 13

- 19 yrs 0.35 0.012830 3.7 0.012 0.002026 17

Adults 20

- 49 yrs 0.35 0.016102 4.6 0.012 0.002502 21

Adults 50

- 99 yrs 0.35 0.015572 4.5 0.012 0.002585 22

Females 13

- 49 yrs 0.35 0.016655 4.8 0.012 0.002585 22

1

- Results for the 99 th and 99.9 th percentile are reported in Attachment 2

. 2

- The population subgroup with the highest estimated exposure/risk is bolded.



## The results reported in Table 5 are for the general U.S. population, all infants (<1 year old),

children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults

50

- 99 years. The acute results summarized in Table 5 are for the 95 th 

## perc entile of exposure. A complete listing of acute exposure and risk estimates can be found in Attachments 1 and 2

, respectively. A complete listing of chronic exposure and risk estimates can be found in Attachments 3 and 4, respectively.

As previously sta ted, for acute and chronic assessments, HED is concerned when dietary risk

exceeds 100% of the PAD. The analyses indicate that the requested uses of thiamethoxam, coupled with currently registered uses, will result in acute and chronic dietary (food + dri nking water) exposures that are below HED’s level of concern for all population subgroups, including

those of infants and children.

The acute assessment indicates that Children 1

- 2 yrs are the most highly

- exposed subgroup, utilizing 9. 4 % of the aPAD, whil e the general US population utilizes 4.9 % of the aPAD; all risk estimates are below HED’s level of concern (Table 5). Similarly, risk estimates for the chronic dietary exposure analysis are below HED’s level of concern, with Children 1

- 2 years being the

m ost highly

- exposed subgroup, utilizing 4 4 % of the chronic population

- adjusted dose (cPAD), while the general U.S. population utilizes 2 2 % of the cPAD.

VIII. Characterization of Inputs/Outputs

This assessment is based on tolerance level or anticipated residues derived from field trial residue data and assumes 100% CT. The exposure values represent high

- end estimates and should be considered to be highly conservative, health

- protective estimates of dietary exposure

and risk. T he Tier I Rice Model used to generate the EDWCs is expected to produce

conservative estimates of pesticides in water bodies well downstream of rice paddies . The

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 14 of 32 modeled estimates may exceed actual pesticide concentrations by less than one order of magnitude to multiple orders of m agnitude.

Various other refinements could be made to the assessments . H owever, as there are no risk

estimates of concern (including aggregate risk concerns) , no additional refinements were incorporated.

IX. Conclusions

B ased on highly conservative assumptions, there are no dietary (food + drinking water) risk

estimates of concern for thiamethoxam

.

HED is confident that the assessment does not underestimate risk to the general U.S. populat ion or any population subgroup.

X. List of Attachments

Attachment 1. Input file for the acute dietary exposure analyses of thiamethoxam.

Attachment 2 . Summary of the acute dietary exposure analysis for thiamethoxam.

Attachment 3. Input file for the chronic dietary exposure analyses of thiamethoxam. Attachment 4. Summary of the chronic dietary exposure analysis for thiamethoxam.

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 15 of 32 Attachment 1. Input File for the Acute Dietary Exposure Estimates.

Filename: C: \ Documents and Setti ngs \ dmcneill \ My Documents \ Thiamethoxam5 \ 060109 2010 ACUTE

T+WATER.R08

Chemical: thiamethoxam RfD(Chronic): .012 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .35 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09

- 26

- 2012/09 :32:49 Program ver. 3.16, 03

- 08

- d

Comment: Acute and Chronic RfDs = aPAD and cPAD

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.050000 1.000 1.000

Full comment: D357449, recommended tol.
0101050001 1AB Beet, garden, roots

- babyfood 0.050000 1.000 1.000
0101052000 1A Beet, sugar 0.050000 1.000 1.000
0101052001 1A Beet, sugar

- babyfood 0.050000 1.000 1.000
0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000
0101053001 1A Beet, sugar, molasses

- babyfood 0.050000 1.000 1.000

0101067000 1AB Burdock 0.050000 1.000 1.000

0101078000 1AB Carrot 0.050000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.050000 1.000 1.000
0101079000 1AB Carrot, juice 0.050000 1.000 1.000

0101084000 1AB Celeria c 0.050000 1.000 1.000
0101100000 1AB Chicory, roots 0.050000 1.000 1.000
0101168000 1AB Ginseng, dried 0.050000 1.000 1.000

0101190000 1AB Horseradish 0.050000 1.000 1.000
0101250000 1AB Parsley, turnip rooted 0.050000 1.000 1.000
0101251000 1AB Parsnip 0.050000 1.000 1.000
0101251001 1AB Parsnip

- babyfood 0.050000 1.000 1.00 0
0101314000 1AB Radish, roots 0.050000 1.000 1.000
0101316000 1AB Radish, Oriental, roots 0.050000 1.000 1.000
0101327000 1AB Rutabaga 0.050000 1.000 1.000

0101331000 1AB Salsi fy, roots 0.050000 1.000 1.000
0101388000 1AB Turnip, roots 0.050000 1.000 1.000
0103296000 1C Potato, chips 0.250000 1.200 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.250000 1.700 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.250000 1.700 1.000
0103298000 1C Potato, flour 0.250000 1.700 1.000
0103298001 1C Potato, flour

- babyfood 0.250000 1.700 1. 000 0103299000 1C Potato, tuber, w/peel 0.250000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.250000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.250000 1.000 1.000
0103366000 1CD Sweet potato 0.020000 1.000 1.000
0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000
0103371000 1CD Tanier, c orm 0.020000 1.000 1.000

0103387000 1CD Turmeric 0.020000 1.000 1.000
0103406000 1CD Yam, true 0.020000 1.000 1.000

0103407000 1CD Yam bean 0.020000 1.000 1.000
0200315000 2 Radish, tops 0.800000 1.000 1.000
0200317000 2 Radish, Oriental, tops 0.800000 1.000 1.000
0301237000 3A Onion, bulb 0.030000 1.000 1.000
0301237001 3A Onion, bulb

- babyfood 0.030000 1.000 1.000
0301238000 3A Onion, bulb, dried 0.030000 9.000 1.000
0301238001 3A Onion, bulb, dried

- babyfood 0.030000 9.000 1.000

0401005000 4A Amarant h, leafy 4.000000 1.000 1.000
0401018000 4A Arugula 4.000000 1.000 1.000
0401104000 4A Chrysanthemum, garland 4.000000 1.000 1.000
0401133000 4A Cress, garden 4.000000 1.000 1.000
0401134000 4A Cress, upland 4.000000 1.000 1.000
0401138000 4A Dandelion, leaves 4.000000 1.000 1.000

0401150000 4A Endive 4.000000 1.000 1.00 0
0401204000 4A Lettuce, head 4.000000 1.000 1.000
0401205000 4A Lettuce, leaf 4.000000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 16 of 32 0401248000 4A Parsley, leaves 4.000000 1.000 1.000

0401313000 4A Radic chio 4.000000 1.000 1.000
0401355000 4A Spinach 4.000000 1.000 1.000
0401355001 4A Spinach

- babyfood 4.000000 1.000 1.000

0402076000 4B Cardoon 4.000000 1.000 1.000
0402085000 4B Celery 4.000000 1.000 1.000
0402085001 4B Celery

- babyfood 4.000000 1.000 1.000
0402086000 4B Celery, j uice 4.000000 1.000 1.000

0402087000 4B Celtuce 4.000000 1.000 1.000
0402152000 4B Fennel, Florence 4.000000 1.000 1.000

0402322000 4B Rhubarb 4.000000 1.000 1.000

0402367000 4B Swiss chard 4.000000 1.000 1.000

0501061000 5A Broccoli 4.500000 1.000 1.000

0501061001 5A Broccoli

- babyfood 4.500000 1.000 1.000
0501062000 5A Broccoli, Chinese 4.500000 1.000 1.000
0501064000 5A Brussels sprouts 4.500000 1.000 1.000
0501069000 5A Cabbage 4.500000 1.000 1.000
0501071000 5A Cabbage , Chinese, napa 4.500000 1.000 1.000
0501072000 5A Cabbage, Chinese, mustard 4.500000 1.000 1.000

0501083000 5A Cauliflower 4.500000 1.000 1.000

0501196000 5A Kohlrabi 4.500000 1.000 1.000

0502063000 5B Broccoli raab 3.000000 1.000 1.000
0502070000 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000

0502117000 5B Collards 3.000000 1.000 1.00 0

0502194000 5B Kale 3.000000 1.000 1.000
0502229000 5B Mustard greens 3.000000 1.000 1.000
0502318000 5B Rape greens 3.000000 1.000 1.000

0502389000 5B Turni p, greens 3.000000 1.000 1.000
0600347000 6 Soybean, seed 0.020000 1.000 1.000
0600349000 6 Soybean, soy milk 0.020000 1.000 1.000
0600349001 6 Soybean, soy milk

- babyfood or in 0.020000 1.000 1.000
0600350000 6 Soybean, oil 0.020000 1.000 1.000
0600350001 6 Soybean, oil

- babyfood 0.020000 1.000 1.000
0601043000 6A Bean, snap, succulent 0.020000 1.000 1.000
0601043001 6A Bean, snap, succulent

- babyfood 0.020000 1.000 1.000
0601257000 6A Pea, edible podded, succulent 0.020000 1.000 1.000
0602031000 6B Bean, broad, succulent 0.020000 1.000 1.000

0602033000 6B B ean, cowpea, succulent 0.020000 1.000 1.000
0602037000 6B Bean, lima, succulent 0.020000 1.000 1.000
0602255000 6B Pea, succulent 0.020000 1.000 1.000
0602255001 6B Pea, succulent

- babyfood 0.020000 1.000 1.000
0602259000 6B Pea, pigeon, succulent 0.020000 1.000 1.000
0603030000 6C Bean, black, seed 0.020000 1.000 1.000
0603032000 6C Bean, broad, seed 0.020000 1.000 1.000
0603034000 6C Bean, cowpea, seed 0.020000 1.000 1.000
0603035000 6C Bean, great northern, seed 0.020000 1.000 1.000
0603036000 6C Bean, kidney, seed 0.020000 1.000 1.000

0603038000 6C Bean, lima, seed 0.020000 1.000 1.000
0603039000 6C Bean, mung, seed 0.020000 1.000 1.000
0603040000 6C Bean, navy, seed 0.020000 1.000 1.000
0603041000 6C Bean, pink, seed 0.020000 1.000 1.000
0603042000 6C Bean, pinto, seed 0.020000 1.000 1.000
0603098000 6C Chickpea, seed 0.020000 1.000 1.000
0603098001 6C Chickpea, seed

- babyfood 0.020000 1.0 00 1.000
0603099000 6C Chickpea, flour 0.020000 1.000 1.000

0603182000 6C Guar, seed 0.020000 1.000 1.000
0603182001 6C Guar, seed

- babyfood 0.020000 1.000 1.000

0603203000 6C Lentil, seed 0.020000 1.000 1.000
0603256000 6C Pea, dry 0.020000 1.000 1.000
0603256001 6C Pea, dry

- babyfood 0.020000 1.000 1.000
0603258000 6C Pea, pigeon, seed 0.020000 1.000 1.000
0603348000 6C Soybean, flour 0.020000 1.000 1.000
0603348001 6C Soybean, flour

- babyfood 0.020000 1.000 1.000

0801374000 8A Tomatillo 0.250000 1.000 1.000

0801375000 8A Tomato 0.250000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.250000 1.000 1.000
0801376000 8A Tomato, paste 0.800000 1.000 1.000 Tol.

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 17 of 32 080137 6001 8A Tomato, paste

- babyfood 0.800000 1.000 1.000 Tol.
0801377000 8A Tomato, puree 0.250000 1.700 1.000
0801377001 8A Tomato, puree

- babyfood 0.250000 1.700 1.000
0801378000 8A Tomato, dri ed 0.250000 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 0.250000 14.300 1.000
0801379000 8A Tomato, juice 0.250000 1.500 1.000
0802148000 8BC Eggplant 0 .250000 1.000 1.000

0802234000 8BC Okra 0.250000 1.000 1.000
0802270000 8B Pepper, bell 0.250000 1.000 1.000
0802270001 8B Pepper, bell

- babyfood 0.250000 1.000 1.000
0802271000 8B Pepper, bell, dried 0.250000 1.000 1.000
0802271001 8B Pepper, bell, dried

- babyfood 0.250000 1.000 1.000
0802272000 8BC Pepper, nonbell 0.250000 1.000 1.000
0802272001 8BC Pepper, n onbell

- babyfood 0.250000 1.000 1.000
0802273000 8BC Pepper, nonbell, dried 0.250000 1.000 1.000
0901075000 9A Cantaloupe 0.200000 1.000 1.000
0901187000 9A Honeydew melon 0.200000 1.000 1.000

0901399000 9A Watermelon 0.200000 1.000 1.000
0901400000 9A Watermelon, juice 0.200000 1.000 1.000
0902021000 9B Balsam pear 0.200000 1.000 1.000
0902088000 9B Chayote, fruit 0.200000 1.000 1.000
0902102000 9B Chinese waxgourd 0.200000 1.000 1.000

0902135000 9B Cucumber 0.200000 1.000 1.000
0902308000 9B Pumpkin 0.200000 1.000 1.000
0902309000 9B Pumpkin, seed 0.200000 1.000 1.000
0902356000 9B Squash, summer 0.200000 1.000 1.000
0902356001 9B Squash, summer

- babyfood 0.200000 1.000 1.000
0902357000 9B Squash, winter 0.200000 1.000 1.000
0902357001 9B Squash, winter

- babyfood 0.200000 1.000 1.000

1001106000 10A Citron 0.400000 1.000 1.000 D34870 3
1001107000 10A Citrus hybrids 0.400000 1.000 1.000
1001108000 10A Citrus, oil 0.400000 0.600 1.000 D34 8 27 2
1001240000 10A Orange 0.400000 1.000 1.000
1001241000 10A Orange, juice 0.400000 0.600 1.000 D34 8 27 2
1001241001 10A Orange, juice

- babyfood 0.400000 0.600 1.000 D34827 2
1001242000 10A Orange , peel 0.400000 1.000 1.000
1001369000 10A Tangerine 0.400000 1.000 1.000
1001370000 10A Tangerine, juice 0.400000 0.600 1.000 D34827 2
1002197000 10B Kumquat 0.400000 1.000 1.000

1002199000 10B Lemon 0.400000 1.000 1.000
1002200000 10B Lemon, juice 0.400000 0.600 1.000 D34827 2
1002200001 10B Lemon, juice

- babyfood 0.40000 0 0.600 1.000 D34927 2
1002201000 10B Lemon, peel 0.400000 1.000 1.000

1002206000 10B Lime 0.400000 1.000 1.000
1002207000 10B Lime, juice 0.400000 0.600 1.000 D34827 2
1002207001 10B Lime, juice

- babyfood 0.400000 0.600 1.000 D34927 2
1003180000 10C Grapefruit 0.400000 1.000 1.000
1003181000 10C Grapefruit, juice 0.400000 0.600 1.000 D34927 2

100 3307000 10C Pummelo 0.400000 1.000 1.000
1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000
1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000
1100008001 11 Apple, peele d fruit

- babyfood 0.200000 1.000 1.000
1100009000 11 Apple, dried 0.200000 8.000 1.000
1100009001 11 Apple, dried

- babyfood 0.200000 8.000 1.000
1100010000 11 Apple, juice 0.200000 0.750 1.000
1100010001 11 Apple, juice

- babyfood 0.200000 0.750 1.000
1100011000 11 Apple, sauce 0.200000 1.000 1.000
1100011001 11 Apple, sa uce

- babyfood 0.200000 1.000 1.000
1100129000 11 Crabapple 0.200000 1.000 1.000
1100210000 11 Loquat 0.200000 1.000 1.000

1100266000 11 Pear 0.200000 1.000 1.000

1100266001 11 Pear

- babyfood 0.200000 1.000 1.000
1100267000 11 Pear, dried 0.200000 6.250 1.000
1100268000 11 Pear, juice 0.200000 1.000 1.000
1100268001 11 Pear, juice

- babyfood 0.200000 1.000 1.000

1100310000 11 Quince 0.200000 1.000 1.000
1201090000 12A Cherry 0.500000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 18 of 32 1201090001 12A Cherry

- babyfood 0.500000 1.000 1.000
1201091000 12A Cherry, juice 0.500000 1.500 1.000
1201091001 12A Cherry, juice

- babyfood 0.500000 1.500 1.000
1202012000 12B Apricot 0.500000 1.000 1.000
1202012001 12B Apricot

- babyfood 0.500000 1.000 1.000
1202013000 12B Apricot, dried 0.500000 6.000 1.000
1202014000 12B Apricot, juice 0.500000 1.000 1.00 0
1202014001 12B Apricot, juice

- babyfood 0.500000 1.000 1.000

1202230000 12B Nectarine 0.500000 1.000 1.000

1202260000 12B Peach 0.500000 1.000 1.000

1202260001 12B Peach

- babyfood 0.500000 1.000 1.000
1202261000 12B Peach, dried 0.500000 7.000 1.000
1202261001 12B Peach, dried

- babyfood 0.500000 7.000 1.000
1202262000 12B Peach, juice 0.500000 1.000 1.000
1202262001 12B Peach, juice

- babyfood 0.500000 1.000 1.000

1203285000 12C Plum 0.500000 1.000 1.000

1203285001 12C Plum

- babyfood 0.500000 1.000 1.000
1203286000 12C Plum, prune, fresh 0.500000 1.000 1.000
1203286001 12C Plum, prune, fresh

- babyfood 0.500000 1.000 1.000
1203287000 12C Plum, prune, dried 0.500000 5.000 1.000
1203287001 12C Plum, prune, dried

- babyfood 0.500000 5.000 1.000
1203288000 12C Plum, prune, juice 0.500000 1.400 1.000
1203288001 12C Plum, prune, juice

- babyfood 0.500000 1.400 1 .000
1301055000 13A Blackberry 0.350000 1.000 1.000
1301056000 13A Blackberry, juice 0.350000 1.000 1.000
1301056001 13A Blackberry, juice

- babyfood 0.350000 1.000 1.000

1301058000 13A Bo ysenberry 0.350000 1.000 1.000
1301208000 13A Loganberry 0.350000 1.000 1.000
1301320000 13A Raspberry 0.350000 1.000 1.000
1301320001 13A Raspberry

- babyfood 0.350000 1.000 1.000
1301321000 13A Raspberry, juice 0.350000 1.000 1.000
1301321001 13A Raspberry, juice

- babyfood 0.350000 1.000 1.000
1302057000 13B Blueberry 0.300000 1.000 1.000
1302057001 13B Blueberry

- babyfood 0.300000 1.000 1.000

1302136000 13B Currant 0.200000 1.000 1.000
1302137000 13B Currant, dried 0.200000 1.000 1.000

1302149000 13B Elderberry 0.200000 1.000 1.000
1302174000 13B Gooseberry 0.200000 1.000 1.000
1302191000 13B Huckleberry 0.200000 1.000 1.000
1304175000 13D Grape 0.200000 1.000 1.000
1304176000 13D Grape, juice 0.200000 1.100 1.000 D28170 2
1304176001 13D Grape, juice

- babyfood 0.200000 1.100 1.000
1304179000 13D Grape, wine and sherry 0.200000 1.000 1.000
1307130000 13G Cranberry 0.020000 1.000 1.000
1307130001 13G Cranberry

- babyfood 0.020000 1.000 1.000
1307131000 13G Cranberry, dried 0.020000 1.000 1.000
1307132000 13G Cranberry, juice 0.020000 1.100 1.000
1307132001 13G Cranberry, juice

- babyfood 0.020000 1.100 1.000
1307359000 13G Strawberry 0.300000 1.000 1.000

1307359001 13G Strawberr y

- babyfood 0.300000 1.000 1.000
1307360000 13G Strawberry, juice 0.300000 1.000 1.000
1307360001 13G Strawberry, juice

- babyfood 0.300000 1.000 1.000

1400003000 14 Almond 0.020000 1.000 1.000

1400003001 14 Almond

- babyfood 0.020000 1.000 1.000
1400004000 14 Almond, oil 0.020000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.020000 1.000 1.000

1400059000 14 Brazil nut 0.020000 1.000 1.000

1400068000 14 Butternut 0.020000 1.000 1.000

1400081000 14 Cashew 0.020000 1.000 1.000

1400092000 14 Chestnu t 0.020000 1.000 1.000

1400155000 14 Hazelnut 0.020000 1.000 1.000
1400156000 14 Hazelnut, oil 0.020000 1.000 1.000
1400185000 14 Hickory nut 0.020000 1.000 1.000

1400213000 14 Macadamia nut 0.020000 1.000 1.000

1400269000 14 Pecan 0.020000 1.000 1.000

1400282000 14 Pistachio 0.020000 1.000 1.00 0

1400391000 14 Walnut 0.020000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 19 of 32 1500025000 15 Barley, pearled barley 0.400000 0.300 1.000 D28170 2
1500025001 15 Barley, pearled barley

- babyfood 0.400000 0.300 1.000 D28170 2

1500026 000 15 Barley, flour 0.400000 0.100 1.000 D28170 2
1500026001 15 Barley, flour

- babyfood 0.400000 0.100 1.000 D28170 2
1500027000 15 Barley, bran 0.400000 0.300 1.000 D28170 2

1500065000 15 Buckwheat 0.020000 1.000 1.000
1500066000 15 Buckwheat, flour 0.020000 1.000 1.000
1500120000 15 Corn, field, flour 0.020000 1.000 1.000
1500120001 15 Corn, field, flour

- babyfood 0.020000 1.000 1.000
1500121000 15 Corn, field, meal 0.020000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000
1500122000 15 Corn, fie ld, bran 0.020000 1.000 1.000
1500123000 15 Corn, field, starch 0.020000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000
1500124000 15 Corn, field, syrup 0.020000 1.500 1.000
1500124001 15 Corn, field, syrup

- babyfood 0.020000 1.500 1.000
1500125000 15 Corn, field, oil 0.020000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.020000 1.000 1.000
1500126000 15 Corn, pop 0.020000 1.000 1.000
1500127000 15 Corn, sweet 0.020000 1.000 1.000
1500127001 15 Corn, sweet

- babyfood 0.020000 1.000 1.000
1500226000 15 Millet, grain 0.020000 1.000 1.000
1500231000 15 Oat, bran 0.020000 1.000 1.000
1500232000 15 Oat, flour 0.020000 1.000 1.000
1500232001 15 Oat, flour

- babyfood 0.020000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.020000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.020000 1.000 1.000
1500323000 15 Rice, white 0.020000 1.000 1.00 0
1500323001 15 Rice, white

- babyfood 0.020000 1.000 1.000
1500324000 15 Rice, brown 0.020000 1.000 1.000
1500324001 15 Rice, brown

- babyfood 0.020000 1.000 1.000
1500325000 15 Rice, flour 0.020000 1.000 1.000
1500325001 15 Rice, flour

- babyfood 0.020000 1.000 1.000
1500326000 15 Rice, bran 0.020000 0.900 1.000 D35744 9
1500326001 15 Rice, bran

- babyfood 0.020000 0.900 1.000 D35744 9
1500328000 15 Rye, grain 0.020000 1.000 1.000
1500329000 15 Rye, flour 0.020000 1.000 1.000
1500344000 15 Sorghum, grain 0.020000 1.000 1.000
1500345000 15 Sorghum, syrup 0.020000 1.000 1.000
1500381000 15 Triticale, flour 0.020000 1.000 1.000

1500381001 15 Triticale , flour

- babyfood 0.020000 1.000 1.000
1500401000 15 Wheat, grain 0.020000 1.000 1.000
1500401001 15 Wheat, grain

- babyfood 0.020000 1.000 1.000
1500402000 15 Wheat, flour 0.020000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.020000 1.000 1.000
1500403000 15 Wheat, germ 0.020000 1.000 1.000
1500404000 15 Wheat, bran 0.020000 1.000 1.000

1500405000 15 Wild rice 0.020000 1.000 1.000
2001163000 20A Flax seed, oil 0.020000 1.000 1.000
2001319000 20A Rapeseed, oil 0.020000 1.000 1.000
2001319001 20A Rapesee d, oil

- babyfood 0.020000 1.000 1.000
2002330000 20B Safflower, oil 0.020000 1.000 1.000
2002330001 20B Safflower, oil

- babyfood 0.020000 1.000 1.000
2002364000 20B Sunflower, seed 0.020000 1.000 1.000
2002365000 20B Sunflower, oil 0.020000 1.000 1.000
2002365001 20B Sunflower, oil

- babyfood 0.020000 1.000 1.000
2003128000 20C Cottonseed, oil 0.100000 1.000 1.00 0
2003128001 20C Cottonseed, oil

- babyfood 0.100000 1.000 1.000
3100044000 31 Beef, meat 0.020000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.020000 1.000 1.000
3100045000 31 Beef, meat, dried 0.020000 1.920 1.000
3100046000 31 Beef, meat byproducts 0.040000 1.000 1.000
3100046001 31 Beef, meat byproducts

- babyfood 0.040000 1.000 1.000
3100048000 31 Beef, kidney 0.040000 1.000 1.000
3100049000 31 Beef, liver 0.040000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 0.040000 1.000 1.000
3200169000 32 Goat, meat 0.020000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 20 of 32 3200170000 32 Goat, meat byproducts 0.040000 1.000 1.000
3200172000 32 Goat, kidney 0.040000 1.000 1.000
3200173000 32 Goat, liver 0.040000 1.000 1.000

3300189000 33 H orse, meat 0.020000 1.000 1.000
3400290000 34 Pork, meat 0.020000 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.020000 1.000 1.000
3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000
3400292001 34 Pork, meat byproducts

- babyfood 0.020000 1.000 1.000
3400294000 34 Pork, kidney 0.020000 1.000 1.000
3400295000 34 Pork, liver 0.020000 1.000 1.000
3500339000 35 Sheep, meat 0.020000 1.000 1.000
3500339001 35 Sheep, meat

- babyfood 0.020000 1.000 1.000
3500340000 35 Sheep, meat byproducts 0.040000 1.000 1.000

3500342000 35 Sheep, kidney 0.040000 1.000 1.000
3500343000 35 Sheep, liver 0.040000 1.000 1.000
3600222000 36 Milk, fat 0.020000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infa nt formu 0.020000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.020000 1.000 1.000

3600224000 36 Milk, water 0.020000 1.0 00 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.020000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.020000 1.000 1.000
3800221000 38 Meat, game 0.020000 1.000 1.000

3900312000 39 Rabbit, meat 0.020000 1.000 1.000
8601000000 86A Water, direct, all sources 0.131770 1.000 1.000 D37337 8
8602000000 86B Water, indirect, all sources 0.131770 1.000 1.000 D37337 8
9500016000 O Artichoke, globe 0.450000 1.000 1.000

9500020000 O Avocado 0.400000 1.000 1.000

9500074000 O Canistel 0.400000 1.000 1.000
9500089000 O Cherimoya 0.110000 1.000 1.000
9500115000 O Coffee, roasted bean 0.200000 1.000 1.000
9500116000 O Coffee, instant 0.200000 1.000 1.000
9500177000 O Grape, leaves 0.200000 1.000 1.000
9500178000 O Grape, raisin 0.300000 1.000 1.000
9500188000 O Hop 0.100000 1.000 1.000
9500215000 O Mango 0.400000 1.000 1.000
9500215001 O Mango

- babyfood 0.400000 1.000 1.000
9500216000 O Mango, dried 0.400000 1.000 1.000
9500217000 O Mango, juice 0.400000 1.000 1.000
9500217001 O Mango, juice

- babyfood 0.400000 1.000 1.000
9500245000 O Papaya 0.400000 1.000 1.000
9500245001 O Papaya

- babyfood 0.400000 1.000 1.000
9500246000 O Papaya, dried 0.400000 1.800 1.000
9500247000 O Papaya, juice 0.400000 1.500 1.000

9500263000 O Peanut 0.050000 1.000 1.000
9500264000 O Peanut, butter 0.050000 1.890 1.00 0
9500265000 O Peanut, oil 0.050000 0.310 1.000 D37636 7
9500275000 O Peppermint 1.500000 1.000 1.000
9500276000 O Peppermint, oil 1.500000 0.050 1.000

9500333000 O Sapote, Mamey 0.400000 1.000 1.000
9500352000 O Spearmint 1.500000 1.000 1.000
9500353000 O Spearmint, oil 1.500000 0.050 1.000 D28170 2

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 21 of 32 Attachment 2. Summary of the acute dietary exposure analysis for thiamethoxam.

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for THIAMETHOXAM NHANES 2003

- 2008 2

- Day

Residue file: 060109 2010 ACUTE T+WATER.R0 8 Adjustment factor #2 NOT used.
Analysis Date: 09

- 26

- 2012/14:26:46 Residue file dated: 09

- 26

- 2012/09:32:49

RAC/FF intake summed over 24 hours

Run Comment: "Acute and Chronic RfDs = aPAD and cPAD"

================================================== =============================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- --- ----- ---------- -------- ---------- -------- Total US Population:

0.017192 4.91 0.027541 7.87 0.048974 13.99

All Infants:

0.027915 7.98 0.038939 11.13 0.075416 21.55

Children 1

- 2 :
0.032992 9.43 0.056203 16.06 0.091348 26.10

Children 3

- 5:

0.027008 7.72 0.043605 12.46 0.087861 25.10

Children 6

- 12:

0.017406 4.97 0.028752 8.21 0 .046149 13.19

Youth 13

- 19:

0.012830 3.67 0.020081 5.74 0.034580 9.88

Adults 20

- 49:

0.016102 4.60 0.023724 6.78 0.045071 12.88

Adults 50

- 99:

0.015572 4.45 0.023018 6.58 0.034280 9.79

Female 13

- 49:

0.016655 4.76 0.025707 7.34 0.045164 12.90

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 22 of 32 Attachment 3. Input File for the Chronic Dietary Exposure Estimates.

Filename: C: \ Documents and Settings \ dmcneill \ My Documents \ Thiamethoxam5 \ 060109 2010

T+FHE+WATER.R08

Chemical: thiamethoxam RfD(Chronic): .012 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .35 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date create d/last modified: 09

- 26

- 2012/08:05:29 Program ver. 3.16, 03

- 08

- d

Comment: Acute and Chronic RfDs = aPAD and cPAD

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet , garden, roots 0.050000 1.000 1.000
0101050001 1AB Beet, garden, roots

- babyfood 0.050000 1.000 1.000
0101052000 1A Beet, sugar 0.050000 1.000 1.000
0101052001 1A Beet, sugar

- babyfood 0.050000 1.000 1.000
0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000
0101053001 1A Beet, sugar, molasses

- babyfood 0.050000 1.000 1.000

0101067000 1AB Burdock 0.050000 1.000 1 .000

0101078000 1AB Carrot 0.050000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.050000 1.000 1.000
0101079000 1AB Carrot, juice 0.050000 1.000 1.000

0101084000 1AB Ce leriac 0.050000 1.000 1.000
0101100000 1AB Chicory, roots 0.050000 1.000 1.000
0101168000 1AB Ginseng, dried 0.050000 1.000 1.000

0101190000 1AB Horseradish 0.050000 1.000 1.000
0101250000 1AB Parsley, turnip rooted 0.050000 1.000 1.000
0101251000 1AB Parsnip 0.050000 1.000 1.000
0101251001 1AB Parsnip

- babyfood 0.050000 1.000 1.000
0101314000 1AB Radish, roots 0.050000 1.000 1.000
0101316000 1AB Radish, Oriental, roots 0.050000 1.000 1.000
0101327000 1AB Rutabaga 0.050000 1.000 1.000

0101331000 1AB Salsify, roots 0.050000 1.000 1.000
0101388000 1AB Turnip, roots 0.050000 1.000 1.000

0103015000 1CD Arrowroot, flour 0.010000 1.000 1.000 FHE
0103015001 1CD Arrowroot, flour

- babyf ood 0.010000 1.000 1.000 FHE
0103017000 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 FHE

0103082000 1CD Cassava 0.010000 1.000 1.000 FHE

0103082001 1CD Cassava

- babyfood 0.0 10000 1.000 1.000 FHE
0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 FHE
0103166000 1CD Ginger 0.010000 1.000 1.000 FHE
0103166001 1CD Ginger

- babyfood 0.010000 1.000 1.000 FHE
0103167000 1CD Ginger, dried 0.010000 1.000 1.000 FHE
0103296000 1C Potato, chips 0.250000 1.200 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.250000 1.700 1.000

0103297001 1C Potato, dry (granules/ flakes)

- b 0.250000 1.700 1.000
0103298000 1C Potato, flour 0.250000 1.700 1.000
0103298001 1C Potato, flour

- babyfood 0.250000 1.700 1.000 0103299000 1C Potato, tuber, w/pee l 0.250000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.250000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.250000 1.000 1.000
0103366000 1CD Sweet potato 0.020000 1.000 1.000
0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000
0103371000 1CD Tanier, corm 0.020000 1.000 1.000

010338700 0 1CD Turmeric 0.250000 1.000 1.000

0103406000 1CD Yam, true 0.020000 1.000 1.000

0103407000 1CD Yam bean 0.020000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 23 of 32 0200051000 2 Beet, garden, tops 0.010000 1.000 1.000 FHE
0200101000 2 Chicory, tops 0.010000 1.000 1.000 FHE

0200140000 2 Dasheen, leaves 0.010000 1.000 1.000 FHE
0200315000 2 Radish, tops 0.010000 1.000 1.000 FHE
0200317000 2 Radish, Oriental, tops 0.010000 1.000 1.000 FHE
0200332000 2 Salsify, tops 0.010000 1.000 1.000 FHE
0301165000 3A Garlic, bulb 0.010000 1.00 0 1.000 FHE
0301165001 3A Garlic, bulb

- babyfood 0.010000 1.000 1.000 FHE
0301237000 3A Onion, bulb 0.030000 1.000 1.000
0301237001 3A Onion, bulb

- babyfood 0.030000 1.000 1.000

03012380 00 3A Onion, bulb, dried 0.030000 9.000 1.000
0301238001 3A Onion, bulb, dried

- babyfood 0.030000 9.000 1.000
0301338000 3A Shallot, bulb 0.000000 1.000 1.000
0302103000 3B Chive, fresh leaves 0.010000 1.000 1.000 FHE

0302198000 3B Leek 0.010000 1.000 1.000 FHE
0302239000 3B Onion, green 0.010000 1.000 1.000 FHE

0302338500 3B Shallot, fresh leaves 0.010000 1.000 1.000 FHE
0401005000 4A Amaranth, leafy 4.000000 1.000 1.000
0401018000 4A Arugula 4.000000 1.000 1.000
0401104000 4A Chrysanthemum, garland 4.000000 1.000 1.000
0401133000 4A Cress, garden 4.000000 1.000 1.000
0401134000 4A Cress, upland 4.000000 1.000 1.000
0401138000 4A Dandelion, leaves 4.000000 1 .000 1.000

0401150000 4A Endive 4.000000 1.000 1.000

0401204000 4A Lettuce, head 4.000000 1.000 1.000
0401205000 4A Lettuce, leaf 4.000000 1.000 1.000

0401248000 4A Parsley, leaves 4.000000 1.000 1.000

0401313000 4A Radicchio 4.000000 1.000 1.000
0401355000 4A Spinach 4.000000 1.000 1.000
0401355001 4A Spinach

- babyfood 4.000000 1.000 1.000

0402076000 4B Cardoon 4.000000 1.000 1.000
0402085000 4B Celery 4.000000 1.000 1.000
0402085001 4B Celery

- babyfood 4.000000 1.000 1.000
0402086000 4B Celery, juice 4.000000 1.000 1.000

0402087000 4B Celtuce 4.000000 1.000 1.000
0402152000 4B Fennel, Florence 4.000000 1.000 1.000

040232200 0 4B Rhubarb 4.000000 1.000 1.000

0402367000 4B Swiss chard 4.000000 1.000 1.000

0501061000 5A Broccoli 0.980000 1.000 1.000 D28170 2

0501061001 5A Broccoli

- ba byfood 0.980000 1.000 1.000
0501062000 5A Broccoli, Chinese 0.980000 1.000 1.000
0501064000 5A Brussels sprouts 0.980000 1.000 1.000
0501069000 5A Cabbage 0.980000 1.000 1.000
0501071000 5A Cabbage, Chinese, napa 0.980000 1.000 1.000
0501072000 5A Cabbage, Chinese, mustard 0.980000 1.000 1.000

0501083000 5A Cauliflow er 0.980000 1.000 1.000

0501196000 5A Kohlrabi 0.980000 1.000 1.000

0502063000 5B Broccoli raab 0.820000 1.000 1.000
0502070000 5B Cabbage, Chinese, bok choy 0.820000 1.000 1.000 D28170 2

0502117000 5B Collards 0.820000 1.000 1.000

0502194000 5B Kale 0.820000 1.000 1.000
0502229000 5B Mustard greens 0.820000 1.000 1.000
0502318000 5B Rape greens 0.820000 1.000 1.000
0502389000 5B Turnip, greens 0.820000 1.000 1.000
0600347000 6 Soybean, seed 0.010000 1.000 1.000 D28170 2

060034900 0 6 Soybean, soy milk 0.010000 1.000 1.000
0600349001 6 Soybean, soy milk

- babyfood or in 0.010000 1.000 1.000
0600350000 6 Soybean, oil 0.010000 1.000 1.000
0600350001 6 Soybean, oil

- babyf ood 0.010000 1.000 1.000
0601043000 6A Bean, snap, succulent 0.010000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 24 of 32 0601043001 6A Bean, snap, succulent

- babyfood 0.010000 1.000 1.000
0601257000 6A Pea, edible podded, succulent 0.010000 1.000 1.000
0601349500 6AB Soybean, vegetable 0.000000 1.000 1.000
0602031000 6B Bean, broad, succulent 0.010000 1.000 1.000
0602033000 6B Bean, cowpea, succulent 0.010000 1.000 1.000

0602037 000 6B Bean, lima, succulent 0.010000 1.000 1.000

0602255000 6B Pea, succulent 0.010000 1.000 1.000
0602255001 6B Pea, succulent

- babyfood 0.010000 1.000 1.000
0602259000 6B Pea, pigeon, suc culent 0.010000 1.000 1.000
0603030000 6C Bean, black, seed 0.010000 1.000 1.000
Full comment: S,. Tayayin, 26 Nov 2002

0603032000 6C Bean, broad, seed 0.010000 1.000 1.000
0603034000 6C Bean, cowpea, seed 0.010000 1.000 1.000
0603035000 6C Bean, great northern, seed 0.010000 1.000 1.000
0603036000 6C Bean, kid ney, seed 0.010000 1.000 1.000
0603038000 6C Bean, lima, seed 0.010000 1.000 1.000
0603039000 6C Bean, mung, seed 0.010000 1.000 1.000
0603040000 6C Bean, navy, seed 0.010000 1.000 1.000
0603041000 6C Bean, pink, seed 0.010000 1.000 1.000
0603042000 6C Bean, pinto, seed 0.010000 1.000 1.000
0603098000 6C Chickpea, seed 0.010000 1.000 1.000
0603098001 6C Chickpea, seed

- babyfood 0.010000 1.000 1.000
0603099000 6C Chickpea, flour 0.010000 1.000 1.000

0603182000 6C Guar, seed 0.010000 1.000 1.000
0603182001 6C Guar, s eed

- babyfood 0.010000 1.000 1.000
0603203000 6C Lentil, seed 0.010000 1.000 1.000
0603256000 6C Pea, dry 0.010000 1.000 1.000
0603256001 6C Pea, dry

- babyfood 0.010000 1.000 1.000
0603258000 6C Pea, pigeon, seed 0.010000 1.000 1.000
0603348000 6C Soybean, flour 0.010000 1.000 1.000
0603348001 6C Soybean, flour

- babyfood 0.010000 1.000 1.00 0

0801374000 8A Tomatillo 0.080000 1.000 1.000

0801375000 8A Tomato 0.080000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.080000 1.000 1.000

0801376000 8A Tomat o, paste 0.080000 3.800 1.000 D26507 9
0801376001 8A Tomato, paste

- babyfood 0.080000 3.800 1.000
0801377000 8A Tomato, puree 0.080000 1.700 1.000 D26507 9
0801377001 8A Tomato, puree

- ba byfood 0.080000 1.700 1.000
0801378000 8A Tomato, dried 0.080000 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 0.080000 14.300 1.000
0801379000 8A Tomato, juice 0.080000 1.500 1.000

0801380000 8A Tomato, Tree 0.010000 1.000 1.000 FHE
0802148000 8BC Eggplant 0.080000 1.000 1.000
Full comment: D281702, tomato

0802234000 8BC Okra 0.080000 1.000 1.000
0802270000 8B Pepper, bell 0.080000 1.000 1.000

Full comment: D281702, pepper
0802270001 8B Pepper, bell

- babyfood 0.080000 1.000 1.000
0802271000 8B Pepper, bell, dried 0.080000 1.000 1.000
0802271001 8B Pepper, bell, dried

- babyfood 0.080000 1.000 1.000
0802272000 8BC Pepper, nonbell 0.080000 1.000 1.000
0802272001 8BC Pepper, nonbell

- babyfood 0.080000 1.000 1.000
0802273000 8BC Pepper, nonbell, dried 0.080000 1.000 1.000

0901075000 9A Cantalo upe 0.200000 1.000 1.000
0901187000 9A Honeydew melon 0.200000 1.000 1.000

0901399000 9A Watermelon 0.200000 1.000 1.000
0901400000 9A Watermelon, juice 0.200000 1.000 1.000
0902021000 9B Balsam pear 0.200000 1.000 1.000
0902088000 9B Chayote, fruit 0.200000 1.000 1.000
0902102000 9B Chinese waxgourd 0.200000 1.000 1.00 0

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 25 of 32 0902135000 9B Cucumber 0.200000 1.000 1.000
0902308000 9B Pumpkin 0.200000 1.000 1.000
0902309000 9B Pumpkin, seed 0.200000 1.000 1.000
0902356000 9B Squas h, summer 0.200000 1.000 1.000
0902356001 9B Squash, summer

- babyfood 0.200000 1.000 1.000
0902357000 9B Squash, winter 0.200000 1.000 1.000
0902357001 9B Squash, winter

- babyfood 0.200000 1.000 1.000

1001106000 10A Citron 0.100000 1.000 1.000
1001107000 10A Citrus hybrids 0.100000 1.000 1.000

1001108000 10A Citrus , oil 0.100000 0.600 1.000
1001240000 10A Orange 0.100000 1.000 1.000
1001241000 10A Orange, juice 0.100000 0.600 1.000
1001241001 10A Orange, juice

- babyfood 0.100000 0.600 1.000
1001242000 10A Orange, peel 0.100000 1.000 1.000
1001369000 10A Tangerine 0.100000 1.000 1.000
1001370000 10A Tangerine, juice 0.100000 0.600 1.0 00
1002197000 10B Kumquat 0.400000 1.000 1.000

1002199000 10B Lemon 0.090000 1.000 1.000
1002200000 10B Lemon, juice 0.090000 0.600 1.000

1002200001 10B Lemo n, juice

- babyfood 0.090000 0.600 1.000
1002201000 10B Lemon, peel 0.090000 1.000 1.000

1002206000 10B Lime 0.100000 1.000 1.000
1002207000 10B Lime, juice 0.100000 2.000 1.000
1002207001 10B Lime, juice

- babyfood 0.100000 2.000 1.000
1003180000 10C Grapefruit 0.070000 1.000 1.000
1003181000 10C Grapefruit, juice 0.070000 0.600 1 .000

1003307000 10C Pummelo 0.100000 1.000 1.000
1100007000 11 Apple, fruit with peel 0.060000 1.000 1.000

Full comment: D281702 & D265079
1100008000 11 Apple , peeled fruit 0.060000 1.000 1.000
1100008001 11 Apple, peeled fruit

- babyfood 0.060000 1.000 1.000
1100009000 11 Apple, dried 0.060000 8.000 1.000
1100009001 11 Apple, dried

- babyfood 0.060000 8.000 1.000
1100010000 11 Apple, juice 0.060000 0.750 1.000
1100010001 11 Apple, juice

- babyfood 0.060000 0.750 1.000
1100011000 11 Apple, sauce 0.060000 1.000 1. 000
1100011001 11 Apple, sauce

- babyfood 0.060000 1.000 1.000
1100129000 11 Crabapple 0.060000 1.000 1.000
1100173500 11 Goji berry 0.000000 1.000 1.000
1100210000 11 Loquat 0.060000 1.000 1.000

1100266000 11 Pear 0.060000 1.000 1.000

1100266001 11 Pear

- babyfood 0.060000 1.000 1.000
1100267000 11 Pear, dri ed 0.060000 6.250 1.000
1100268000 11 Pear, juice 0.060000 0.750 1.000
1100268001 11 Pear, juice

- babyfood 0.060000 0.750 1.000

1100310000 11 Quince 0.060000 1.000 1.000
1201090000 12A Cherry 0.210000 1.000 1.000
1201090001 12A Cherry

- babyfood 0.210000 1.000 1.000
1201091000 12A Cherry, juice 0.210000 1.500 1.000
1201091001 12A Cherry, juice

- babyfood 0.210000 1.500 1.000
1202012000 12B Apricot 0.070000 1.000 1.000
Full comment: W. Cuthchin 12/10/03 DERs
1202012001 12B Apricot

- ba byfood 0.070000 1.000 1.000
1202013000 12B Apricot, dried 0.070000 6.000 1.000
1202014000 12B Apricot, juice 0.070000 1.000 1.000
1202014001 12B Apricot, juice

- babyfood 0.070000 1.000 1.000

1202230000 12B Nectarine 0.070000 1.000 1.000

1202260000 12B Peach 0.070000 1.000 1.000

1202260001 12B Peach

- babyfood 0.070000 1.000 1.000
1202261000 12B Peach, dried 0.070000 7.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 26 of 32 1202261001 12B Peach, dried

- babyfood 0.070000 7.000 1.000
1202262000 12B Peach, juice 0.070000 1.000 1.000
1202262001 12B Peach, j uice

- babyfood 0.070000 1.000 1.000

1203285000 12C Plum 0.071000 1.000 1.000

1203285001 12C Plum

- babyfood 0.071000 1.000 1.000

1203286000 12C Plum , prune, fresh 0.071000 1.000 1.000
1203286001 12C Plum, prune, fresh

- babyfood 0.071000 1.000 1.000
1203287000 12C Plum, prune, dried 0.071000 5.000 1.000
1203287001 12C Plum, prune, dried

- babyfood 0.071000 5.000 1.000
1203288000 12C Plum, prune, juice 0.071000 1.400 1.000
1203288001 12C Plum, prune, juice

- babyfood 0.071000 1.400 1.000
1301055000 13A Blackberry 0.120000 1.000 1 .000 D28170 2
1301056000 13A Blackberry, juice 0.120000 1.000 1.000
1301056001 13A Blackberry, juice

- babyfood 0.120000 1.000 1.000
1301058000 13A Boysenberry 0.120000 1.000 1.000

1301208000 13A Loganberry 0.120000 1.000 1.000
1301320000 13A Raspberry 0.120000 1.000 1.000
1301320001 13A Raspberry

- babyfood 0.120000 1.000 1.000
1301321000 13A Raspberry, juice 0.120000 1.000 1.000
1301321001 13A Raspberry, juice

- babyfood 0.120000 1.000 1.000
1302057000 13B Blueberry 0.300000 1.000 1.000
1302057001 13B Blueberry

- babyfood 0.300000 1.000 1.000

1302136000 13B Currant 0.200000 1.000 1.000
1302137000 13B Currant, dried 0.200000 1.000 1.000
1302149000 13B Elderberry 0.200000 1.000 1.000

130217400 0 13B Gooseberry 0.200000 1.000 1.000
1302191000 13B Huckleberry 0.200000 1.000 1.000
1303227000 13C Mulberry 0.010000 1.000 1.000 FHE
1304175000 13D Grape 0.060000 1.000 1.000 D28170 2
1304176000 13D Grape, juice 0.060000 1.100 1.000
1304176001 13D Grape, juice

- babyfood 0.060000 1.100 1.000
1304179000 13D Grape, wine and sherry 0.060000 1.000 1.000
1304195000 13D Kiwifruit, fuzzy 0.010000 1.000 1.000 FHE
1307130000 13G Cranberry 0.020000 1.000 1.000
1307130001 13G Cranberry

- babyfood 0.020000 1.000 1.000
1307131000 13G Cranberry, dried 0.020000 1.000 1.000
1307132000 13G Cranberry, juice 0.020000 1.100 1.000
1307132001 13G Cranberry, juice

- babyfood 0.020000 1.100 1.000
1307359000 13G Strawberry 0.300000 1.000 1.000
1307359001 13G Strawberry

- babyfood 0.300000 1.000 1.000
1307360000 13G Strawberry, juice 0.300000 1.000 1.000
1307360001 13G Strawberry, juice

- babyfood 0.300000 1.000 1.000

1400003000 14 Almond 0.010000 1.000 1.000 D34927 2

1400003001 14 Almond

- babyfood 0.010000 1.000 1.000

1400004000 14 Almond, oil 0.010000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.010000 1.000 1.000

1400059000 14 Brazil nut 0.010000 1.000 1.000

1400068000 14 Butternut 0.010000 1.000 1.000

1400081000 14 Cashew 0.010000 1.000 1.000

1400092000 14 Chestnut 0.010000 1.000 1.000

1400155000 14 Hazelnut 0.010000 1.00 0 1.000
1400156000 14 Hazelnut, oil 0.010000 1.000 1.000
1400185000 14 Hickory nut 0.010000 1.000 1.000

1400213000 14 Macadamia nut 0.010000 1.000 1.000

1400269000 14 Pecan 0.010000 1.000 1.000

1400278000 14 Pine nut 0.010000 1.000 1.000 FHE

1400282000 14 Pistachio 0.010000 1.000 1.000

1400391000 14 Walnut 0.010000 1.000 1.000
1500025000 15 Barley, pearled barley 0.086000 0.300 1.000
Full comment: D281702/D325447

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 27 of 32 1500025001 15 Barley, pearled barley

- babyfood 0.086000 0 .300 1.000
1500026000 15 Barley, flour 0.086000 0.100 1.000
1500026001 15 Barley, flour

- babyfood 0.086000 0.100 1.000
1500027000 15 Barley, bran 0.086000 0.300 1.000

1500065000 15 Buckwheat 0.020000 1.000 1.000
1500066000 15 Buckwheat, flour 0.020000 1.000 1.000
1500120000 15 Corn, field, flour 0.020000 1.000 1.000
1500120001 15 Corn, fie ld, flour

- babyfood 0.020000 1.000 1.000
1500121000 15 Corn, field, meal 0.020000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000
1500122000 15 Corn, field, bran 0.020000 1.000 1.000
1500123000 15 Corn, field, starch 0.020000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000
1500124000 15 Corn, field, syrup 0.020000 1.500 1.000
1500124001 15 Corn, field, syrup

- babyfood 0.020000 1.500 1.000
1500125000 15 Corn, field, oil 0.020000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.020000 1.000 1.000
1500126000 15 Corn, p op 0.020000 1.000 1.000
1500127000 15 Corn, sweet 0.020000 1.000 1.000
1500127001 15 Corn, sweet

- babyfood 0.020000 1.000 1.000
1500226000 15 Millet, grain 0.020000 1.000 1.000
1500231000 15 Oat, bran 0.020000 1.000 1.000
1500232000 15 Oat, flour 0.020000 1.000 1.000
1500232001 15 Oat, flour

- babyfood 0.020000 1.000 1.00 0 1500233000 15 Oat, groats/rolled oats 0.020000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.020000 1.000 1.000
1500323000 15 Rice, white 0.010000 1.000 1.000
1500323001 15 Rice, white

- babyfood 0.010000 1.000 1.000
1500324000 15 Rice, brown 0.010000 1.000 1.000
1500324001 15 Rice, brown

- babyfood 0.010000 1.000 1.000
1500325000 15 Rice, flour 0.010000 1.000 1.000
1500325001 15 Rice, flour

- babyfood 0.010000 1.000 1.000
1500326000 15 Rice, bran 0.010000 0.900 1.000
1500326001 15 Rice, bran

- babyfood 0.010000 0.900 1.000
1500328000 15 Rye, grain 0.020000 1.000 1.000
1500329000 15 Rye, flour 0.020000 1.000 1.000
1500344000 15 Sorghum, grain 0.020000 1.000 1.000

1500345000 15 S orghum, syrup 0.020000 1.000 1.000
1500381000 15 Triticale, flour 0.020000 1.000 1.000
1500381001 15 Triticale, flour

- babyfood 0.020000 1.000 1.000
1500401000 15 Wheat, grain 0.020000 1.000 1.000
1500401001 15 Wheat, grain

- babyfood 0.020000 1.000 1.000
1500402000 15 Wheat, flour 0.020000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.020000 1.000 1.000
1500403000 15 Wheat, germ 0.020000 1.000 1.000
1500404000 15 Wheat, bran 0.020000 1.000 1.000

1500405000 15 Wild rice 0.020000 1.000 1.000

1800002000 18 Alfalfa, seed 0.010000 1.000 1.000 FHE
1901028000 19A Basil, fresh leaves 0.010000 1.000 1.000 FHE
1901028001 19A Basil, fresh leaves

- babyfood 0.010000 1.000 1.000 FHE
1901029000 19A Basil, dried le aves 0.010000 1.000 1.000 FHE
1901029001 19A Basil, dried leaves

- babyfood 0.010000 1.000 1.000 FHE
1901102500 19A Chive, dried leaves 0.000000 1.000 1.000
1901118000 19A Cilantro, leaves 0.010000 1.000 1.000 FHE
1901118001 19A Cilantro, leaves

- babyfood 0.010000 1.000 1.000 FHE

1901144000 19A Dillweed 0.010000 1.000 1.000 FHE

1901184000 19A Herbs, other 0.010000 1.00 0 1.000 FHE
1901184001 19A Herbs, other

- babyfood 0.010000 1.000 1.000 FHE
1901202000 19A Lemongrass 0.010000 1.000 1.000 FHE
1901220000 19A Marjoram 0.010000 1.000 1.000 FHE

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 28 of 32 19 01220001 19A Marjoram

- babyfood 0.010000 1.000 1.000 FHE
1901249000 19A Parsley, dried leaves 0.010000 1.000 1.000 FHE
1901249001 19A Parsley, dried leaves

- babyfood 0.010000 1.000 1.000 FHE

1901334000 19A Savory 0.010000 1.000 1.000 FHE

1902105000 19B Cinnamon 0.010000 1.000 1.000 FHE

1902105001 19B Cinnamon

- babyfood 0.010000 1.000 1.000 FHE
1902119000 19B Coriander, seed 0.010000 1.000 1.000 FHE
1902119001 19B Coriander, seed

- babyfood 0.010000 1.000 1.000 FHE
1902143000 19B Dill, seed 0.010000 1.000 1.000 FHE
1902274000 19B Pepper, black and white 0.010000 1.000 1.000 FHE
1902274001 19B Pepper, black and white

- babyfood 0.010000 1.000 1.000 FHE
1902354000 19B Spices, other 0.010000 1.000 1.000 FHE
1902354001 19B Spices, other

- babyfood 0.010000 1. 000 1.000 FHE
2001163000 20A Flax seed, oil 0.020000 1.000 1.000 Tol.
2001319000 20A Rapeseed, oil 0.020000 1.000 1.000
2001319001 20A Rapeseed, oil

- babyfood 0.020000 1.000 1.000

20013 36000 20A Sesame, seed 0.010000 1.000 1.000 FHE
2001336001 20A Sesame, seed

- babyfood 0.010000 1.000 1.000 FHE
2001337000 20A Sesame, oil 0.010000 1.000 1.000 FHE

2001337001 20A Sesam e, oil

- babyfood 0.010000 1.000 1.000 FHE
2002330000 20B Safflower, oil 0.020000 1.000 1.000
2002330001 20B Safflower, oil

- babyfood 0.020000 1.000 1.000
2002364000 20B Sunflower, seed 0.020000 1.000 1.000
2002365000 20B Sunflower, oil 0.020000 1.000 1.000
2002365001 20B Sunflower, oil

- babyfood 0.020000 1.000 1.000
2003114001 20C Coconut, oil

- babyfood 0.010000 1.000 1.000 FHE
2003128000 20C Cottonseed, oil 0.100000 1.000 1.000
2003128001 20C Cottonseed, oil

- babyfood 0.100000 1.000 1.000

2100228000 21 Mushroom 0.010000 1.000 1.000 FHE

3100044000 31 Beef, meat 0.020000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.020000 1.000 1.000
3100045000 31 Beef, meat, dried 0.020000 1.920 1.000
3100046000 31 Beef, meat byproducts 0.040000 1.000 1.000 Rec.T ol.
3100046001 31 Beef, meat byproducts

- babyfood 0.040000 1.000 1.000
3100047000 31 Beef, fat 0.010000 1.000 1.000 FHE

3100047001 31 Beef, fat

- babyfood 0.010000 1.000 1.000 FHE
3100048000 31 Beef, kidney 0.040000 1.000 1.000
3100049000 31 Beef, liver 0.040000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 0.040000 1.000 1.000
3200169000 32 Goat, meat 0.020000 1.000 1.000
3200170000 32 Goat, meat byproducts 0.040000 1.000 1.000 Rec. T ol.
3200171000 32 Goat, fat 0 .005000 1.000 1.000 FHE
3200172000 32 Goat, kidney 0.040000 1.000 1.000
3200173000 32 Goat, liver 0.040000 1.000 1.000

3300189000 33 Horse, meat 0.020000 1.000 1.000
3400290000 34 Pork, meat 0.020000 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.020000 1.000 1.000
3400291000 34 Pork, skin 0.010000 1.000 1.000 FHE

3400292000 34 Por k, meat byproducts 0.020000 1.000 1.000
3400292001 34 Pork, meat byproducts

- babyfood 0.020000 1.000 1.000
3400293000 34 Pork, fat 0.010000 1.000 1.000 FHE
3400293001 34 Pork, fat

- babyfood 0.010000 1.000 1.000 FHE
3400294000 34 Pork, kidney 0.020000 1.000 1.000
3400295000 34 Pork, liver 0.020000 1.000 1.000
3500339000 35 Sheep, meat 0.020000 1 .000 1.000
3500339001 35 Sheep, meat

- babyfood 0.020000 1.000 1.000
3500340000 35 Sheep, meat byproducts 0.040000 1.000 1.000
3500341000 35 Sheep, fat 0.010000 1.000 1.000 FHE

35003410 01 35 Sheep, fat

- babyfood 0.010000 1.000 1.000 FHE
3500342000 35 Sheep, kidney 0.040000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 29 of 32 3500343000 35 Sheep, liver 0.040000 1.000 1.000
3600222000 36 Milk, fat 0.020000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.020000 1.000 1.000

3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000
3600223001 36 Milk, non fat solids

- baby food/in 0.020000 1.000 1.000

3600224000 36 Milk, water 0.020000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.020000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.020000 1.000 1.000
3800221000 38 Meat, game 0.020000 1.000 1.000
3900312000 39 Rabbit, meat 0.020000 1.000 1.000
4000093000 40 Chicken, meat 0.010000 1.000 1.000 FHE
4000093001 40 Chicken, meat

- babyfood 0.010000 1.000 1.000 FHE
4000094000 40 Chicken, liver 0.010000 1.000 1.000 FHE
4000095000 40 Chicken, meat byproducts 0.010000 1.000 1.000 FHE

4000095001 40 Chicken, meat byproducts

- babyfoo 0.010000 1.000 1.000 FHE
4000096000 40 Chicken, fat 0.010000 1.000 1.000 FHE
4000096001 40 Chicken, fat

- babyfood 0.010000 1.000 1.000 FHE
4000097000 40 Chicken, sk in 0.010000 1.000 1.000 FHE
4000097001 40 Chicken, skin

- babyfood 0.010000 1.000 1.000 FHE
5000382000 50 Turkey, meat 0.010000 1.000 1.000 FHE
5000382001 50 Turkey, meat

- babyfood 0.010000 1.000 1.000 FHE
5000383000 50 Turkey, liver 0.010000 1.000 1.000 FHE
5000383001 50 Turkey, liver

- babyfood 0.010000 1.000 1.000 FHE
5000384000 50 Turkey, meat byproducts 0.010000 1.000 1.000 FHE
5000384001 50 Turkey, meat byproducts

- babyfood 0.010000 1.000 1.000 FHE
5000385000 50 Turkey, fat 0.010000 1.000 1.000 FHE
5000385001 50 Turkey, fat

- babyfood 0.010000 1.000 1.000 FHE 5000386000 50 Turkey, skin 0.010000 1.000 1.000 FHE
5000386001 50 Turkey, skin

- babyfood 0.010000 1.000 1.000 FHE
6000301000 60 Poultry, other, meat 0.010000 1.000 1.000 FHE
6000302000 60 Poultry, other, liver 0.010000 1.000 1.000 FHE
6000303000 60 Poultry, other, meat byproducts 0.010000 1.000 1.000 FHE
6000304000 60 Poultry, other, fat 0.010000 1.000 1.000 FHE

6000305000 60 Poultry, other, skin 0.010000 1.000 1.000 FHE
7000145000 70 Egg, whole 0.010000 1.000 1.000 FHE
7000145001 70 Egg, whole

- babyfood 0.010000 1.000 1.000 FHE
7000146000 70 Egg, white 0.010000 1.000 1.000 FHE
7000146001 70 Egg, white (solids)

- babyfood 0.010000 1.000 1.000 FHE
7000147000 70 Egg, yolk 0.010000 1.000 1.000 FHE
7000147001 70 Egg, yolk

- babyfood 0.010000 1.000 1.000 FHE

8000157000 80 Fish

- freshwater finfish 0.010000 1.000 1.000 FHE

8000158000 80 Fish

- freshwater finfish, farm ra 0.010000 1.000 1.000 FHE

8000159000 80 Fish

- saltwater finfish, tuna 0.010000 1. 000 1.000 FHE

8000160000 80 Fish

- saltwater finfish, other 0.010000 1.000 1.000 FHE

8000161000 80 Fish

- shellfish, crustacean 0.010000 1.000 1.000 FHE

8000162000 80 Fish

- shellfish, mollusc 0.010000 1.000 1.000 FHE
8601000000 86A Water, direct, all sources 0.011310 1.000 1.000
8601100000 86A Water, direct, tap 0.000000 1.000 1.000
8601200000 86A Water, direct, bottled 0.000000 1.000 1.000
8601300000 86A Water, di rect, other 0.000000 1.000 1.000
8601400000 86A Water, direct, source

- NS 0.000000 1.000 1.000
8602000000 86B Water, indirect, all sources 0.011310 1.000 1.000
8602100000 86B Water, indirect, tap 0.000000 1.000 1.000
8602200000 86B Water, indirect, bottled 0.000000 1.000 1.000
8602300000 86B Water, indirect, other 0.000000 1.000 1.000
8602400000 86B Water, indirect, source

- NS 0.000000 1.000 1.000
9500000500 O Acai berry 0.000000 1.000 1.000

9500001000 O Acerola 0.010000 1.000 1.000 FHE
9500001500 O Agave 0.000000 1.000 1.000
9500006000 O Amaranth, grain 0.010000 1.000 1.000 FHE

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 30 of 32 9500016000 O Artichoke, globe 0.190000 1.000 1.000
Full comment: D281702/D325447
9500019000 O Asparagu s 0.010000 1.000 1.000 FHE
9500019500 O Atemoya 0.000000 1.000 1.000

9500020000 O Avocado 0.110000 1.000 1.000

F ull comment: D357449/D357450

9500022000 O Bamboo, shoots 0.010000 1.000 1.000 FHE

9500023000 O Banana 0.010000 1.000 1.000 FHE

9500023001 O Banana

- babyfood 0.010000 1.000 1.000 FHE
9500024000 O Banana, dried 0.010000 1.000 1.000 FHE
9500024001 O Banana, dried

- babyfood 0.010000 1.000 1.000 FHE
9500054000 O Belgium endive 0.010000 1.000 1.000 FHE

950 0060000 O Breadfruit 0.010000 1.000 1.000 FHE

9500073000 O Cactus 0.010000 1.000 1.000 FHE

9500074000 O Canistel 0.400000 1.000 1.000

9500077000 O Carob 0.010000 1.000 1.000 FHE
9500089000 O Cherimoya 0.110000 1.000 1.000
9500109000 O Cocoa bean, chocolate 0.010000 1.000 1.000 FHE
9500110000 O Cocoa bean, powder 0.010000 1.000 1.000 FHE
9500111000 O Coconut, meat 0.010000 1.000 1.000 FHE
9500111001 O Coconut, meat

- babyfood 0.010000 1.000 1.000 FHE
9500112000 O Coconut, dried 0.0100 00 1.000 1.000 FHE
9500113000 O Coconut, milk 0.010000 1.000 1.000 FHE
9500114000 O Coconut, oil 0.010000 1.000 1.000 FHE

9500115000 O Coffee, roasted bean 0.200000 1.000 1.00 0
9500116000 O Coffee, instant 0.200000 1.000 1.000

9500141000 O Date 0.010000 1.000 1.000 FHE
9500151000 O Feijoa 0.010000 1.000 1.000 FHE
9500153000 O Fig 0.010000 1.000 1.000 FHE
9500154000 O Fig, dried 0.010000 1.000 1.000 FHE
9500177000 O Grape, leaves 0.200000 1.000 1.000

9500178000 O Gra pe, raisin 0.060000 2.300 1.000

Full comment: D281702

9500183000 O Guava 0.010000 1.000 1.000 FHE

9500183001 O Guava

- babyfood 0.010000 1.000 1.000 FHE

9500 186000 O Honey 0.010000 1.000 1.000 FHE
9500186001 O Honey

- babyfood 0.010000 1.000 1.000 FHE
9500188000 O Hop 0.100000 1.000 1.000

9500193000 O Jackfru it 0.010000 1.000 1.000 FHE
9500209000 O Longan 0.010000 1.000 1.000 FHE
9500211000 O Lychee 0.010000 1.000 1.000 FHE
9500212000 O Lychee, dried 0.010000 1.000 1.000 FHE
9500214000 O Mamey apple 0.010000 1.000 1.000 FHE
9500215000 O Mango 0.110000 1.000 1.000

Full comment: D357449, avacado
9500215001 O Mango

- babyfood 0.110000 1.000 1.000
9500216000 O Mango, dried 0.110000 1.000 1.000
9500217000 O Mango, juice 0.110000 1.000 1.000

95002170 01 O Mango, juice

- babyfood 0.110000 1.000 1.000
9500218000 O Maple, sugar 0.010000 1.000 1.000 FHE
9500219000 O Maple syrup 0.010000 1.000 1.000 FHE

9500235000 O Olive 0.010000 1.000 1.000 FHE
9500236000 O Olive, oil 0.010000 1.000 1.000 FHE

9500243000 O Palm heart, leaves 0.010000 1.000 1.000 FHE
9500244000 O Palm, oil 0.010000 1.000 1.000 FHE
9500244001 O Palm, oil

- babyfood 0.010000 1.000 1.000 FHE
9500245000 O Papaya 0.110000 1.000 1.000
9500245001 O Papaya

- babyfood 0.110000 1.000 1.000
9500246000 O Papaya, dried 0.110000 1.800 1.000
9500247000 O Papaya, juice 0.110000 1.500 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 31 of 32 9500252000 O Passionfruit 0.010000 1.000 1.000 FHE

9500252 001 O Passionfruit

- babyfood 0.010000 1.000 1.000 FHE
9500253000 O Passionfruit, juice 0.010000 1.000 1.000 FHE
9500253001 O Passionfruit, juice

- babyfood 0.010000 1.000 1.000 FHE
9500254000 O Pawpaw 0.010000 1.000 1.000 FHE

9500263000 O Peanut 0.050000 1.000 1.000
9500264000 O Peanut, butter 0.050000 1.890 1.000
9500265000 O Peanut, oil 0.050000 0.310 1.000
9500275000 O Peppermint 1.500000 1.000 1.000
9500276000 O Peppermint, oil 1.500000 0.050 1.000

9500277000 O Persimmon 0.010000 1.000 1 .000 FHE
9500279000 O Pineapple 0.010000 1.000 1.000 FHE
9500279001 O Pineapple

- babyfood 0.010000 1.000 1.000 FHE
9500280000 O Pineapple, dried 0.010000 1.000 1.000 FHE

950028 1000 O Pineapple, juice 0.010000 1.000 1.000 FHE
9500281001 O Pineapple, juice

- babyfood 0.010000 1.000 1.000 FHE

9500283000 O Plantain 0.010000 1.000 1.000 FHE

9500284000 O Planta in, dried 0.010000 1.000 1.000 FHE
9500289000 O Pomegranate 0.010000 1.000 1.000 FHE
9500306000 O Psyllium, seed 0.010000 1.000 1.000 FHE
9500311000 O Quinoa, grain 0.010000 1.000 1.000 FHE
9500333000 O Sapote, Mamey 0.400000 1.000 1.000

9500335000 O Seaweed 0.010000 1.000 1.000 FHE

9500335001 O Seaweed

- babyfood 0.0100 00 1.000 1.000 FHE
9500346000 O Soursop 0.010000 1.000 1.000 FHE
9500351000 O Spanish lime 0.010000 1.000 1.000 FHE
9500352000 O Spearmint 1.500000 1.000 1.000
9500353000 O Spearmint, oil 1.500000 0.050 1.000 D281702

9500358000 O Starfruit 0.010000 1.000 1.000 FHE
9500361000 O Sugar apple 0.010000 1.000 1.000 FHE 9500362000 O Sugarcane, sugar 0.010000 1.000 1.000 FHE
9500362001 O Sugarcane, sugar

- babyfood 0.010000 1.000 1.000 FHE
9500363000 O Sugarcane, molasses 0.010000 1.000 1.000 FHE

9500363001 O Sugarcane, molasses

- babyfood 0.010000 1.000 1.000 FHE

9500368000 O Tamarind 0.010000 1.000 1.000 FHE
9500372000 O Tea, dried 0.010000 1.000 1.000 FHE
9500373000 O Tea, instant 0.010000 1.000 1.000 FHE
9500373500 O Teff, flour 0.000000 1.000 1.000
9500390000 O Vinegar 0.010000 1.000 1.000 FHE

9500397000 O Water chestnut 0.000000 1.000 1.000

9500398000 O Watercress 0.000000 1.000 1.000

## Thiametho xam (060109) Dietary Exposure and Risk Assessment DP Number D406562

Page 32 of 32 Attachment 4. Summary of the chronic dietary exposure analysis for thiamethoxam.

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for THIAMETHOXAM NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and Settings \ dmcneill \ My

Documents \ Thiamethoxam5 \ 060109 2010 T+FHE+WATER.R08 Adjustment factor #2 NOT used.
Analysis Date 09

- 26

- 2012/09:36:22 Residue file dated: 09

- 26

- 2012/08:05:29 Reference dose (RfD, Chronic) = .012 mg/kg bw/day

COMMENT 1: Acute and Chronic RfDs = aPAD and cPAD

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.002663 22.2%
Hispanic 0.002547 21.2%

Non

- Hisp

- White 0.002754 22.9%

Non

- Hisp

- Black 0.002134 17.8%

Non

- Hisp

- Other 0.003014 25.1%
Nursing Infants 0.001493 12.4%

Non

- Nursing Infants 0.003037 25.3%

Female 13+ PREG 0.002501 20.8%

Children 1

- 6 0.004625 38.5%

Children 7

- 12 0.002599 21.7%

Male 13

- 19 0.001950 16.3%

Female 13

- 19/NP 0.002104 17.5%

Male 20+ 0.002315 19.3%
Female 20+/NP 0.002740 22.8%

Seniors 55+ 0.002576 21.5%

All Infants 0.002560 21.3%

Female 13

- 50 0.002584 21.5%

Children 1

- 2 0.005286 44.1%

Children 3

- 5 0.004446 37.1%

Children 6

- 12 0.0 02767 23.1%

Youth 13

- 19 0.002026 16.9%

Adults 20

- 49 0.002502 20.9%

Adults 50

- 99 0.002585 21.5%

Female 13

- 49 0.002585 21.5%

-------------------------------------------------------------------------------