SAT Report

PMN Number: P-12-0406

SAT Date: 6/29/2012

Print Date: 4/1/2014

Related cases:

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 3

 Persistence Bioaccum Toxicity Comments

3 12

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: P2REC: SAT: SAT recommends not sending this forward.

Keywords:

 Keywords: DEVEL, THYMUS, LIVER, SPLEEN, BLOOD, LUNG, IRR, 

AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-12-0406

FATE: Estimations for neutralized anion 

log Kow = 3.13 (E)

log Koc = 2.95 (E)

log Fish BCF = 1.73 (E)
log Fish BAF = 2.04 (E)

PMN Substance: Solid 

S = Disp.

VP < 1.0E-6 torr at 25 C (E)

BP > 400 C (E)

H < 1.00E-8 (E)

POTW removal (%) = 0 via possible partial biodeg

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = low 

PBT Potential: P3B1

*CEB FATE: Migration to ground water = rapid

 Health:

 Health Summary: Absorption is nil through the skin as the neat material, 

moderate through the skin when in solution, and good through the lungs and GI tract based on 

physical/chemical properties. There is concern for lung effects if inhaled and irritation based on 

the surfactant properties of the PMN material. There is concern for liver and thymus effects and 

developmental toxicity based on the submitted study for an analog 

 with a paternal NOEL = 10 mg/kg and a 

developmental NOEL = 50 mg/kg. There is also conceren for blood and spleen toxicity based on 

data submitted for an unidentified analogue with a LOAEL of 15 mg/kg.

 Test Data: P-12-0406: rat oral LD0 = 2500 mg/kg; a series of 

one-dose 28-day oral studies were conducted with compounds that may or may not be analogues 

of the PMN substance (test substances were identified by code number only), the lowest LOAEL 

for these compounds was 15 mg/kg with effects to the blood, liver, and spleen

negative in Salmonella and E coli with and without activation

oral absorption/metabolism study in rats - serum half-life is approximately 6 hours (males only)

corrosive to the rabbit eye

mild skin irritant in rabbits

not a dermal sensitizer in guinea pigs, Magnusson and Kligman

acute oral study in rats - 2 of 6 died at 2000 mg/kg, lethargy, ventro-lateral recumbency, hunched 

posture, uncoordinated movements, flat gait, shallow respiration, piloerection, salivation

negative for induction of chromosome aberrations in cultured human lymphocytes with and

without activation

oral combined repeated dose toxicity study with reproduction/developmental screening toxicity 

test in rats (10, 50, 250 mg/kg) - salivation, perioral substance and urine-stained abdominal fur at 

250 mg/kg; reduced body weight gain and feed consumption at 50 and 250 mg/kg, microscopic 

changes in liver at 50 and 250 mg/kg; microscopic changes in thymus at 250 mg/kg; no effects 

on FOB and motor activity; no reproductive effects; reduced number of liveborn pups and 

increase in stillborn pups at 250 mg/kg; reduced viability of pups and reduced pup weights at 
250 mg/kg; paternal NOEL = 10 mg/kg; developmental NOEL = 50 mg/kg

oral absorption/metabolism study in rats (males and females only) - analytic phase of study not 

completed due to problems with the animals

no skin irritation in rabbits

oral absorption/metabolism study in rats (male and female) - halflife in serum = 17 hours

slight eye irritant in rabbits

not a dermal sensitizer in guinea pigs, Magnusson and Kligman

acute oral study in rats - no deaths at 2000 mg/kg, lethargy, uncoordinated movements, hunched 

posture, chromodacryorrhea

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 ≥1.0

daphnid 48-h LC50 ≥1.0

green algal 96-h EC50 ≥1.0

fish _ chronic value ≥0.10

daphnid _ chronic 

value

≥0.10

algal _ chronic 

value

≥0.10

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for anionic surfactants and 

sulfonamides, and uncertainty; SAR chemical class = 

surfactant-anionic ; MW 316; effective concentrations based on 

100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and 

TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

10

SARs anionic surfactants

SAR Class surfactant-anionic

Ecotox Category Anionic Surfactants

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916