Exhibit 4.3


 


AstraZeneca Finance LLC, as Issuer,


 




AstraZeneca PLC, as Guarantor


 


and


 


The Bank of New York Mellon, as Trustee


 


Indenture


 


Dated as of                   
, 2021


 









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ASTRAZENECA FINANCE LLC


 


ASTRAZENECA PLC


 


Reconciliation and tie between Trust Indenture
Act of 1939, as amended including by the Trust Indenture Reform Act of 1990, and Indenture, dated as of                    
, 2021.


 


	Trust Indenture

    Act Section	 	       Securities

    Indenture Section
	ss.310(a)(1)	 	5.08
	(a)(2)	 	5.08
	(a)(3)	 	Not Applicable
	(a)(4)	 	Not Applicable
	(b)	 	5.09
	(c)	 	Not Applicable
	ss.311(a)	 	5.05
	(b)	 	5.05
	(c)	 	Not Applicable
	ss.312(a)	 	3.07
	(b)	 	3.08
	(c)	 	3.08
	ss.313(a)	 	3.12
	(b)	 	3.12
	(c)	 	3.12
	(d)	 	3.12
	ss.314(a)	 	3.11
	(b)	 	Not Applicable
	(c)(1)	 	3.06/10.05
	(c)(2)	 	3.06/10.05
	(c)(3)	 	Not Applicable
	(d)	 	Not Applicable
	(e)	 	3.06/10.05
	(f)	 	Not Applicable
	ss.315(a)	 	5.01
	(b)	 	4.11
	(c)	 	5.01
	(d)	 	5.01
	(d)(1)	 	5.01
	(d)(2)	 	5.01
	(d)(3)	 	5.01
	(e)	 	4.11
	ss.316(a)(1)(A)	 	4.09
	(a)(l)(B)	 	4.10
	(a)(2)	 	Not Applicable
	(b)	 	4.07
	(c)	 	6.02
	ss.317(a) (1)	 	4.02
	(a)(2)	 	4.02
	(b)	 	3.05
	ss.318(a)	 	10.07


 









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NOTE: This reconciliation and tie shall not, for
any purpose, be deemed to be a part of the Indenture.


 









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Contents


 


	Clause	Page




 


Article 1

DEFINITIONS


 


	Section 1.01	Certain Terms Defined.	1




 


Article 2

SECURITIES


 


	Section 2.01	Forms Generally	7
	 	 	 
	Section 2.02	Form of Global Security	7
	 	 	 
	Section 2.03	Form of Registered Security	16
	 	 	 
	Section 2.04	Form of Bearer Security	25
	 	 	 
	Section 2.05	Form of Coupon	35
	 	 	 
	Section 2.06	Form of Legend for Global Registered Securities	36
	 	 	 
	Section 2.07	Form of Trustee’s Certificate of Authentication	36
	 	 	 
	Section 2.08	Amount Unlimited; Issuable in Series	37
	 	 	 
	Section 2.09	Authentication and Delivery of Securities	39
	 	 	 
	Section 2.10	Execution of Securities and Guaranty	40
	 	 	 
	Section 2.11	Certificate of Authentication	40
	 	 	 
	Section 2.12	Denomination and Date of Securities; Payments of Interest	41
	 	 	 
	Section 2.13	Registration, Transfer and Exchange	41
	 	 	 
	Section 2.14	Mutilated, Defaced, Destroyed, Lost and Stolen Securities	45
	 	 	 
	Section 2.15	Cancellation of Securities; Destruction Thereof	45
	 	 	 
	Section 2.16	Temporary Securities	46
	 	 	 
	Section 2.17	CUSIP Numbers	46




 


Article 3

COVENANTS OF THE ISSUER, THE GUARANTOR AND THE TRUSTEE


 


	Section 3.01	Payment of Principal and Interest	46
	 	 	 
	Section 3.02	Additional Amounts	47
	 	 	 
	Section 3.03	Offices for Payments, etc.	48
	 	 	 
	Section 3.04	Appointment to Fill a Vacancy in Office of Trustee	49
	 	 	 
	Section 3.05	Payment Agents	49
	 	 	 
	Section 3.06	Compliance Certificates from the Issuer	50




 









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	Section 3.07	Securityholders List	50
	 	 	 
	Section 3.08	Preservation of Information; Communication to Holders	50
	 	 	 
	Section 3.09	Limitation on Liens	50
	 	 	 
	Section 3.10	Limitation on Sale and Lease-Back	53
	 	 	 
	Section 3.11	Reports by the Issuer and the Guarantor	53
	 	 	 
	Section 3.12	Reports by the Trustee	54




 


Article 4

REMEDIES OF THE TRUSTEE AND

SECURITYHOLDERS ON EVENT OF DEFAULT


 


	Section 4.01	Event of Default Defined; Acceleration of Maturity; Waiver of Default	54
	 	 	 
	Section 4.02	Collection of Indebtedness by Trustee; Trustee May Prove Debt	56
	 	 	 
	Section 4.03	Application of Proceeds	58
	 	 	 
	Section 4.04	Suits for Enforcement	59
	 	 	 
	Section 4.05	Restoration of Rights on Abandonment of Proceedings	59
	 	 	 
	Section 4.06	Limitations on Suits by Securityholders	59
	 	 	 
	Section 4.07	Unconditional Right of Securityholders to Institute Certain Suits	60
	 	 	 
	Section 4.08	Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default	60
	 	 	 
	Section 4.09	Control by Securityholders	60
	 	 	 
	Section 4.10	Waiver of Past Defaults	61
	 	 	 
	Section 4.11	Trustee to Give Notice of Default, but May Withhold in Certain Circumstances	61
	 	 	 
	Section 4.12	Right of Court to Require Filing of Undertaking to Pay Costs	61




 


Article 5

CONCERNING THE TRUSTEE


 


	Section 5.01	Duties and Responsibilities of the Trustee; During Default; Prior to Default	62
	 	 	 
	Section 5.02	Certain Rights of the Trustee	62
	 	 	 
	Section 5.03	Trustee Not Responsible for Recitals, Disposition of Securities or Application of Proceeds Thereof	65
	 	 	 
	Section 5.04	Trustee and Agents May Hold Securities; Collections, Etc.	65
	 	 	 
	Section 5.05	Moneys Held by Trustee	65
	 	 	 
	Section 5.06	Compensation and Indemnification of Trustee and its Prior Claim	65
	 	 	 
	Section 5.07	Right of Trustee to Rely on Officers’ Certificate, etc.	66




 









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	Section 5.08	Persons Eligible for Appointment as Trustee	67
	 	 	 
	Section 5.09	Resignation and Removal; Appointment of Successor Trustee	67
	 	 	 
	Section 5.10	Acceptance of Appointment by Successor Trustee	68
	 	 	 
	Section 5.11	Merger, Conversion, Consolidation or Succession to Business of Trustee	69
	 	 	 
	Section 5.12	FATCA	70




 


Article 6

CONCERNING THE SECURITYHOLDERS


 


	Section 6.01	Evidence of Action Taken by Securityholders	70
	 	 	 
	Section 6.02	Proof of Execution of Instruments and of Holding of Securities; Record Date	70
	 	 	 
	Section 6.03	Holders to Be Treated as Owners	71
	 	 	 
	Section 6.04	Securities Owned by Issuer Deemed Not Outstanding	71
	 	 	 
	Section 6.05	Right of Revocation of Action Taken	71




 


Article 7

SUPPLEMENTAL INDENTURES


 


	Section 7.01	Supplemental Indentures Without Consent of Securityholders	72
	 	 	 
	Section 7.02	Supplemental Indentures with Consent of Securityholders	73
	 	 	 
	Section 7.03	Effect of Supplemental Indenture	74
	 	 	 
	Section 7.04	Documents to be Given to Trustee	75
	 	 	 
	Section 7.05	Notation on Securities in Respect of Supplemental Indentures	75
	 	 	 
	Section 7.06	Conformity with Trust Indenture Act of 1939	75




 


Article 8

CONSOLIDATION OR MERGER


 


	Section 8.01	Issuer May Consolidate, etc., on Certain Terms	76
	 	 	 
	Section 8.02	Securities to be Secured in Certain Events	77
	 	 	 
	Section 8.03	Successor Person to be Substituted for Issuer	77
	 	 	 
	Section 8.04	Opinion of Counsel to Trustee	78




 


Article 9

SATISFACTION AND DISCHARGE OF INDENTURE; UNCLAIMED MONEYS


 


	Section 9.01	Satisfaction and Discharge of Indenture	78
	 	 	 
	Section 9.02	Application by Trustee of Funds Deposited for Payment of Securities	79
	 	 	 
	Section 9.03	Defeasance upon Deposit of Moneys or Government Obligations	79
	 	 	 
	Section 9.04	Repayment of Moneys Held by Paying Agent	80




 









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	Section 9.05	Return of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years	80
	 	 	 
	Section 9.06	Reinstatement	81




 


Article 10

MISCELLANEOUS PROVISIONS


 


	Section 10.01	Incorporators, Stockholders, Officers and Directors of Issuer and Guarantor Exempt from Individual Liability	81
	 	 	 
	Section 10.02	Provisions of Indenture for the Sole Benefit of Parties and Securityholders	81
	 	 	 
	Section 10.03	Successors and Assigns of Issuer and Guarantor Bound by Indenture	81
	 	 	 
	Section 10.04	Notices and Demands on Issuer, Guarantor, Trustee and Securityholders	82
	 	 	 
	Section 10.05	Officers’ Certificates and Opinions of Counsel; Statements to be Contained Therein	82
	 	 	 
	Section 10.06	Payments Due on Saturdays, Sundays and Holidays	83
	 	 	 
	Section 10.07	Conflict of any Provision of Indenture with Trust Indenture Act of 1939	83
	 	 	 
	Section 10.08	New York Law to Govern; Waiver of Jury Trial	83
	 	 	 
	Section 10.09	Counterparts	84
	 	 	 
	Section 10.10	Effect of Headings	84
	 	 	 
	Section 10.11	Submission to Jurisdiction	84
	 	 	 
	Section 10.12	Electronic Means	85
	 	 	 
	Section 10.13	Force Majeure.	86
	 	 	 
	Section 10.14	Consequential Damages	86




 


Article 11

REDEMPTION OF SECURITIES AND SINKING FUNDS


 


	Section 11.01	Applicability of Article	86
	 	 	 
	Section 11.02	Notice of Redemption; Partial Redemptions	86
	 	 	 
	Section 11.03	Payment of Securities Called for Redemption	87
	 	 	 
	Section 11.04	Exclusion of Certain Securities from Eligibility for Selection for Redemption	88
	 	 	 
	Section 11.05	Mandatory and Optional Sinking Funds	88
	 	 	 
	Section 11.06	Optional Redemption Due to Changes in Tax Treatment	90




 









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Article 12

GUARANTY


 


	Section 12.01	Guaranty of Issuer’s Securities	92
	 	 	 
	Section 12.02	Unconditional Nature of Obligations	92
	 	 	 
	Section 12.03	Costs	94
	 	 	 
	Section 12.04	Consolidation, Merger, Sale of Assets	95
	 	 	 
	Section 12.05	Reimbursement of the Guarantor	96
	 	 	 
	Section 12.06	Term	97
	 	 	 
	Section 12.07	Amendments and Waivers	97
	 	 	 
	Section 12.08	Form of Guaranty	97




 









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THIS INDENTURE, dated as of
                 , 2021, among AstraZeneca Finance LLC,
a Delaware limited liability company (the “Issuer”), AstraZeneca PLC, an English public limited company, as guarantor
(the “Guarantor”), and The Bank of New York Mellon, a New York banking corporation, as trustee (the “Trustee”),


 


W I T N E S S E T H:


 


WHEREAS, the Issuer may issue
from time to time in one or more series its unsecured debentures, notes or other evidences of indebtedness (the “Securities”)
represented by one or more Global Securities or by definitive Securities in registered form without coupons for payments, up to such principal
amount or amounts as may from time to time be authorized in accordance with the terms of this Indenture and to provide, among other things,
for the authentication, delivery and administration thereof, the Issuer has duly authorized the execution and delivery of this Indenture;


 


WHEREAS, the Guarantor may
issue a Guaranty in connection with the issuance of Securities by the Issuer; and


 


WHEREAS, all things necessary
to make this Indenture a valid indenture and agreement according to its terms have been done;


 


NOW, THEREFORE:


 


In consideration of the premises
and the purchases of the Securities by the Holders thereof, the Issuer, the Guarantor and the Trustee mutually covenant and agree for
the equal and proportionate benefit of the respective Holders from time to time of the Securities as follows:


 


Article 1

DEFINITIONS


 


Section 1.01         Certain
Terms Defined. The following terms (except as otherwise expressly provided or unless the context otherwise clearly requires) for
all purposes of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section.
All other terms used in this Indenture that are defined in the Trust Indenture Act of 1939 or the definitions of which in the Securities
Act of 1933, as amended, are referred to in the Trust Indenture Act of 1939, including terms defined therein by reference to the Securities
Act of 1933, as amended (except as herein otherwise expressly provided or unless the context otherwise clearly requires), shall have
the meanings assigned to such terms in said Trust Indenture Act of 1939 and in said Securities Act as in force at the date of this Indenture.
All accounting terms used herein and not expressly defined shall have the meanings assigned to such terms in accordance with generally
accepted accounting principles, and the term “generally accepted accounting principles” means such accounting principles
as are applicable to the Person in question and generally accepted at the time of any computation. The words “herein,” “hereof”
and “hereunder” and other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or
other subdivision. The terms defined in this Article have the meanings assigned to them in this Article and include the plural
as well as the singular.


 


“Agent Member”
means a member of, or participant in, a Depositary.


 






    1


     


    

 


“Attributable Debt”
in respect of a Sale and Lease-Back Transaction means, as of any particular time, the present value (discounted at a rate equal to the
weighted average of the rate of interest of the Securities Outstanding hereunder, which in the case of Original Issue Discount Securities
shall be the Yield to Maturity of such Securities (such average being weighted by the principal amount of the Securities of each series
Outstanding or, in the case of Original Issue Discount Securities, such amount to be determined as provided in the definition of “Outstanding”)
compounded semi-annually) of the obligation of the Guarantor or a Restricted Subsidiary for rental payments during the remaining term
of any lease in respect of a Sale and Lease-Back Transaction, including in each case any period for which any such lease has been extended.
Such rental payments shall not include amounts payable by or on behalf of the lessee for maintenance and repairs, insurance, taxes, assessments,
water rates and similar charges.


 


“Authorized Officer”
has the meaning specified in Section 10.12.


 


“Board of Directors”
(1) when used with reference to the Issuer, means either the Board of Directors or any committee or member of such Board duly authorized
to act hereunder of the Issuer, and (2) when used with reference to the Guarantor, means either the Board of Directors or any committee
or member of such Board duly authorized to act hereunder of the Guarantor.


 


“Board Resolution”,
(1) when used with reference to the Issuer, means a copy of one or more resolutions, certified by the Secretary or an Assistant Secretary
of the Issuer, to have been duly adopted by the Board of Directors of the Issuer and to be in full force and effect, and delivered to
the Trustee, and (2) when used with reference to the Guarantor, means a copy of one or more resolutions, certified by the Secretary
or an Assistant Secretary of the Guarantor, to have been duly adopted by the Board of Directors of the Guarantor and to be in full force
and effect, and delivered to the Trustee.


 


“Business Day”
means, with respect to any Security, a day other than a Saturday or Sunday that (a) in the city (or in any of the cities, if more
than one) in which amounts are payable, as specified in the form of such Security, is not a day on which banking institutions are authorized
by law, regulation or executive order to close and (b) if the Security is denominated in a currency other than United States dollars
(i) is not a day on which banking institutions are required by law or regulation to close in the financial center or centers (where
applicable) of the country issuing the currency and (ii) is a day on which banking institutions in such financial center or centers
(where applicable) are carrying out transactions in such currency.


 


“Code”
has the meaning specified in Section 3.02.


 


“Commission”
means the Securities and Exchange Commission, as from time to time constituted, created under the Securities Exchange Act of 1934, as
amended, or if at any time after the execution and delivery of this Indenture such Commission is not existing and performing the duties
now assigned to it under the Trust Indenture Act of 1939, then the body performing such duties on such date.


 


“Company Order”
means a written statement, request or order signed in the name of the Issuer by any director or any other Person duly authorized thereto
by Board Resolution or any other Authorized Officer.


 






    2


     


    

 


“Consolidated Net
Tangible Assets” means the aggregate amount of consolidated total assets of the Guarantor, after deducting therefrom (a) all
liabilities due within one year (other than (x) short-term borrowings and (y) long-term debt due within one year) and (b) all
goodwill, trade names, trademarks, patents and other like intangibles, as shown on the audited consolidated balance sheet of the Guarantor
contained in the latest annual report to shareholders of the Guarantor.


 


“Corporate Trust
Office” means the office of the Trustee at which at any particular time its corporate trust business shall be principally administered,
which office at the date of the execution of this Indenture is located at 240 Greenwich Street, Floor 7 East, New York, New York 10286,
Attention: Corporate Trust Division - Corporate Finance Unit, or such other address as the Trustee may designate from time to time by
notice to the Issuer, or the principal corporate trust office of any successor Trustee (or such other address as such successor Trustee
may designate from time to time by notice to the Issuer).


 


“Debt”
has the meaning specified in Section 3.09.


 


“Depositary”
means, with respect to Securities issuable or issued in whole or in part in the form of one or more Global Securities, the Person designated
as Depositary by the Issuer pursuant to Section 2.08 which must be a clearing agency registered under the Securities Exchange Act
of 1934, as amended (or a successor Depositary), and if at any time there is more than one such Person, “Depositary” as used
with respect to the Securities shall mean the respective Depositary with respect to particular Securities.


 


“Event of Default”
means any event or condition specified as such in Section 4.01.


 


“FATCA”
has the meaning specified in Section 3.02.


 


“Global Security”
means a global certificate evidencing all or part of a series of Securities, authenticated and delivered to the Depositary and registered
in the name of the Depositary or its nominee.


 


“Government Obligations”
means securities that are (i) direct obligations of the United States of America or any foreign government of a sovereign state for
the payment of which its full faith and credit is pledged or (ii) obligations of an entity controlled or supervised by and acting
as an agency or instrumentality of the United States of America or such foreign government the payment of which is unconditionally guaranteed
as a full faith and credit obligation by the United States of America or such foreign government, as the case may be, which, in either
case under clauses (i) or (ii) are not callable or redeemable at the option of the issuer thereof, and shall also include a
depositary receipt issued by a bank or trust company as custodian with respect to any such government obligation or specific payment of
interest on or principal of any such government obligation held by such custodian for the account of the holder of a depositary receipt;
provided that (except as required by law) such custodian is not authorized to make any deduction from the amount payable to the holder
of such depositary receipt from any amount received by the custodian in respect of the government obligation or the specific payment of
interest on or principal of the government obligation evidenced by such depositary receipt.


 


“Guaranteed Obligations”
has the meaning specified in Section 12.01.


 






    3


     


    

 


“Guarantor”
means the Person named as the “Guarantor” in the first paragraph of this Indenture until a successor Person shall have become
such pursuant to the applicable provisions of this Indenture, and thereafter “Guarantor” shall mean such successor Person;
provided that the term “Guarantor,” when used with respect to any Security or the Securities of any series, means the Persons
who shall from time to time be the guarantors of such Security or the Securities of such series, respectively, as set forth in Article 12.


 


“Guaranty”
means the guaranty of the Guaranteed Obligations by the Guarantor set forth in Article 12; provided that the term “Guaranty,”
when used with respect to any Security or with respect to the Securities of any series, means a guaranty of such Guaranteed Obligations
relating to such Security or of the Securities of such series, respectively, by the Guarantor as set forth in Article 12.


 


“Holder”,
 “Holder of Securities”, “Securityholder” or other similar terms mean the registered holder of any
Security.


 


“Indenture”
means this instrument as originally executed and delivered or, if amended or supplemented as herein provided, as so amended or supplemented
or both, including, for all purposes of this instrument, any supplemental or amended indenture, the provisions of the Trust Indenture
Act of 1939 that are deemed to be a part of, and govern this instrument, and any supplemental or amended indenture. The term “Indenture”
shall also include the forms and terms of particular series of Securities established as contemplated hereunder.


 


“Interest”
means, when used with respect to non-interest bearing Securities, interest payable after maturity.


 


“Issuer”
means AstraZeneca Finance LLC, a Delaware limited liability company, and, subject to Article 8, its successors and assigns.


 


“Officers’
Certificate” means a certificate delivered by the Issuer or the Guarantor, as applicable, to the Trustee and signed by any director
or the treasurer or any deputy treasurer or any assistant treasurer and the secretary or any assistant secretary of the Issuer or the
Guarantor, as applicable. Each such certificate shall comply with section 314 of the Trust Indenture Act of 1939 and include the statements
provided for in Section 10.05, if and to the extent required thereby.


 


“Opinion of Counsel”
means an opinion in writing signed by legal counsel, who may be an employee of or counsel to the Issuer or the Guarantor, and who shall
be acceptable to the Trustee. Each such opinion shall comply with section 314 of the Trust Indenture Act of 1939 and include the statements
provided for in Section 10.05, if and to the extent required thereby.


 


“Original issue date”
of any Security (or portion thereof) means the earlier of (a) the date of such Security or (b) the date of any Security (or
portion thereof) for which such Security was issued (directly or indirectly) on registration of transfer, exchange or substitution.


 


“Original Issue Discount
Security” means any Security that provides for an amount less than the principal amount thereof to be due and payable upon a
declaration of acceleration of the maturity thereof pursuant to Section 4.01.


 






    4


     


    

 



 


“Outstanding”,
when used with reference to Securities, shall, subject to the provisions of Section 6.04, mean, as of any particular time, all Securities
authenticated and delivered by the Trustee under this Indenture, except:


 


(a)           Securities
theretofore cancelled by the Trustee or delivered to the Trustee for cancellation;


 


(b)           Securities,
or portions thereof, for the payment or redemption of which moneys in the necessary amount shall have been deposited in trust with the
Trustee or with any paying agent (other than the Issuer) or shall have been set aside, segregated and held in trust by the Issuer for
the Holders of such Securities (if the Issuer shall act as its own paying agent); provided that if such Securities, or portions thereof,
are to be redeemed prior to the maturity thereof, notice of such redemption shall have been given as herein provided, or provision satisfactory
to the Trustee shall have been made for giving such notice; and


 


(c)           Securities
in substitution for which other Securities shall have been authenticated and delivered, or which shall have been paid, pursuant to the
terms of Section 2.09 (except with respect to any such Security as to which proof satisfactory to the Trustee is presented that such
Security is held by a person in whose hands such Security is a legal, valid and binding obligation of the Issuer).


 


In determining whether the
Holders of the requisite principal amount of Outstanding Securities of any or all series have given any request, demand, authorization,
direction, notice, consent or waiver hereunder, (i) the principal amount of an Original Issue Discount Security that shall be deemed
to be Outstanding for such purposes shall be the amount of the principal thereof that would be due and payable as of the date of such
determination upon a declaration of acceleration of the maturity thereof pursuant to Section 4.01 and (ii) the principal amount
of a security denominated in one or more foreign currencies or currency units shall be the U.S. dollar equivalent determined in the manner
provided or contemplated by Article 1 on the date of original issuance of such Security of the principal amount (or, in the case
of an Original Issue Discount Security, the U.S. dollar equivalent on the date of original issuance of such Security of the amount determined
as provided in (i) above) of such Security.


 


“Person”
means any individual, corporation, limited liability company, partnership, joint venture, association, joint stock company, trust, unincorporated
organization or government or any agency or political subdivision thereof.


 


“Predecessor Security”
means, with respect to any Security, every previous Security evidencing all or a portion of the same debt as that evidenced by such particular
Security, and, for the purposes of this definition, any Security authenticated and delivered under Section 2.14 in lieu of a destroyed,
lost or stolen Security shall be deemed to evidence the same debt as the destroyed, lost or stolen Security.


 


“principal”
whenever used with reference to the Securities or any Security or any portion thereof, shall be deemed to include “and premium,
if any.”


 


“Principal Property”
means any manufacturing plant or facility or any research facility owned by the Guarantor or any Restricted Subsidiary which is located
within the United Kingdom or the United States of America the gross book value (without deduction of any depreciation reserve) of which
on the date as of which the determination is being made exceeds 2% of Consolidated Net Tangible Assets, except (i) any such plant
or facility or research facility which, in the opinion of the Board of Directors of the Guarantor, is not of material importance to the
total business conducted by the Guarantor and its Subsidiaries considered as a whole or (ii) any portion of any such property which,
in the opinion of the Board of Directors of the Guarantor, is not of material importance to the use or operation of such property.


 






    5


     


    

 


“Relevant Taxing
Jurisdiction” means (i) in respect of payments by the Issuer, the United States; and (ii) in respect of
payments by the Guarantor, the jurisdiction in which it is resident for tax purposes (presently the United Kingdom).


 


“Responsible Officer”
means, with respect to the Trustee, any officer assigned to the Corporate Trust Division – Global Unit (or any successor division
or unit) of the Trustee located at the Corporate Trust Office of the Trustee who shall have direct responsibility for the administration
of this Indenture, and for the purposes of Section 5.01(c)(ii) shall also include any other officer of the Trustee to whom any
corporate trust matter is referred because of such officer’s knowledge of and familiarity with the particular subject.


 


“Restricted Subsidiary”
means any Wholly Owned Subsidiary of the Guarantor (i) substantially all the property of which is located within the United Kingdom
or the United States of America and (ii) which owns a Principal Property; provided, however, that the term “Restricted Subsidiary”
shall not include any Wholly Owned Subsidiary which is principally engaged in leasing or in financing installment receivables or which
is principally engaged in financing the operations of the Guarantor and its consolidated Subsidiaries.


 


“Sale and Lease-Back
Transaction” has the meaning specified in Section 3.10.


 


“Security”
or “Securities” has the meaning stated in the first recital of this Indenture, or, as the case may be, Securities that
have been authenticated and delivered under this Indenture.


 


“Subsidiary”
means, with respect to any Person, any Person at least a majority of the outstanding stock of which having by the terms thereof ordinary
voting power (not dependent upon the happening of a contingency) to elect a majority of the board of directors of such Person is at the
time owned or controlled directly or indirectly by such Person.


 


“Trustee”
means the Person identified as “Trustee” in the first paragraph hereof and, subject to the provisions of Article 5, shall
also include any successor trustee.


 


“Trust Indenture
Act of 1939” (except as otherwise provided in Sections 7.01 and 7.02) means the Trust Indenture Act of 1939 as in force at the
date as of which this Indenture was originally executed; provided, however, that if the Trust Indenture Act of 1939 is amended after such
date, “Trust Indenture Act of 1939” means, to the extent required by any such amendment, the Trust Indenture Act of 1939,
as so amended.


 


“Wholly Owned Subsidiary”
means any Person of which all of the outstanding stock (other than directors’ qualifying shares, if any) having by the terms thereof
ordinary voting power (not dependent upon the happening of a contingency) to elect the board of directors of such Person is at the time
owned or controlled directly or indirectly by the Guarantor, or by one or more Wholly Owned Subsidiaries or by the Guarantor and one or
more Wholly Owned Subsidiaries.


 


“Yield to Maturity”
means the yield to maturity on any series of Original Issue Discount Securities, calculated at the time of issuance of such series, or,
if applicable, at the most recent redetermination of interest on such series, and calculated in accordance with either the constant interest
method or such other accepted financial practice as is specified in the terms of such series established pursuant to Section 2.08.


 






    6


     


    

 


Article 2

SECURITIES


 


Section 2.01         Forms
Generally. The Securities of each series (including the notation thereon relating to the Guaranty) shall be substantially in such
form (not inconsistent with this Indenture) as shall be established by or pursuant to a resolution of the Board of Directors of each of
the Issuer (with respect to the Securities) and the Guarantor (with respect to its Guaranty) (and set forth in a Board Resolution and,
to the extent established pursuant to (rather than in) such resolutions, in an Officers’ Certificate detailing such establishment),
or in one or more indentures supplemental hereto, in each case with such insertions, omissions, substitutions and other variations as
are required or permitted by this Indenture and may have imprinted or otherwise reproduced thereon such legend or legends, not inconsistent
with the provisions of this Indenture, as may be required to comply with any law or with any rules or regulations pursuant thereto,
or with any rules of any securities exchange or to conform to general usage, all as may be determined by the officers executing such
Securities, as evidenced by their execution of the Securities.


 


The definitive Securities shall be printed, lithographed
or engraved on steel engraved borders or may be produced in any other manner, all as determined by the officers executing such Securities,
as evidenced by their execution of such Securities.


 


Section 2.02         Form of
Global Security.


 


[Form of Face of Global Security]


 


[Insert any legend required
by the Internal Revenue Code and the regulations thereunder.]


 


ASTRAZENECA FINANCE LLC

[Title of Security]


 


	No.	 	 	 	 	 CUSIP NO.




 


AstraZeneca Finance
LLC, a Delaware limited liability company (herein called the “Issuer,” which term includes any successor Person under the
Indenture hereinafter referred to), for value received, hereby promises to pay to bearer upon presentation and surrender of this Security
the principal sum of ____________________ on ____________________[if the Security is to bear interest prior to Maturity, insert -,
and to pay interest thereon from ____________________, 20__ or from the most recent Interest Payment Date to which interest has been paid
or duly provided for, semi-annually in arrears on     and     in
each year] [annually in arrears on ____________     in each year], commencing
____________________, 20__, at the rate of ___% per annum, until the principal hereof is paid or made available for payment [if applicable,
insert -; provided that any principal and premium, and any such instalment of interest, which is overdue shall bear interest at the
rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are
due until they are paid or made available for payment, and such interest shall be payable on demand]. [If the Security is not to bear
interest prior to Maturity, insert - The principal of this Security shall not bear interest except in the case of a default in payment
of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium
shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from
the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on
demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of __% per
annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until the
amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] [The Trustee shall
act as Paying Agent with respect to the Securities of this series.]


 






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[The Issuer, the Guarantor,
the Trustee and any agent of the Issuer, the Guarantor or the Trustee may treat the bearer hereof as the owner of this Security for all
purposes, whether or not this Security shall be overdue, and none of the Issuer, the Guarantor, the Trustee nor any such agent shall be
affected by notice to the contrary.]


 


[Title to this Security shall
pass by delivery.]


 


Reference is hereby made to
the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same
effect as if set forth at this place.


 


[All terms used in this Security
which are defined in the Indenture shall have the meanings assigned to them in the Indenture.]


 


Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent,
by manual or pdf or other electronic image scan signature of the Trustee created on an electronic platform (such as DocuSign) or by digital
signing (such as Adobe Sign) of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be
valid or obligatory for any purpose.


 


IN WITNESS WHEREOF, the Issuer
has caused this instrument to be duly executed manually or in facsimile or by electronic image scan signature.


 


Dated:


 


	 	AstraZeneca Finance LLC
	 	 	 
	 	By:	 
	 	 	 
	 		Name:
	 	 	 
	 		Title:



 


[Form of Reverse of Global Security]


 


This Security is one of a
duly authorized issue of securities of the Issuer (herein called the “Securities”), issued and to be issued in one
or more series under an Indenture, dated as of                    ,
2021 (herein called the “Indenture” which term shall have the meaning assigned to it in such instrument), among the
Issuer, the Guarantor and The Bank of New York Mellon, as Trustee (herein called the “Trustee,” which term includes
any other successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Issuer, the Guarantor, the Trustee and the Holders of the Securities and
of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated
on the face hereof [, limited in aggregate principal amount to U.S.$ __________________].


 






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[If applicable, insert
- The Securities of this series are subject to redemption upon not less than 10 nor more than 60 days’ notice as provided in the
Indenture [if applicable, insert - (1) on ____________________ in any year commencing with the year ______ and ending with
the year ______ through operation of the sinking fund for this series at a Redemption Price equal to [insert formula for determining
amount] (with the amount in excess of 100% of the principal amount being additional interest), and (2)] at any time [if applicable,
insert - on or after _________, 20 __], as a whole or in part, at the election of the Issuer, at the following Redemption Prices (expressed
as percentages of the principal amount): If redeemed [if applicable, insert - on or before _________, __%, and if redeemed] during
the 12-month period beginning _________ of the years indicated,


 


	Year	Redemption Price	Year	Redemption Price 


 


and thereafter at a Redemption Price equal to
____% of the principal amount, together in the case of any such redemption [if applicable, insert - (whether through operation
of the sinking fund or otherwise)] with accrued interest to the Redemption Date, but interest instalments whose Stated Maturity is on
or prior to such Redemption Date will be payable only upon presentation and surrender of this Security as provided in the Indenture.]


 


[If applicable, insert
- The Securities of this series are subject to redemption upon not less than 10 nor more than 60 days’ notice as provided in
the Indenture (1) on ____________________ in any year commencing with the year ____ and ending with the year ______, through operation
of the sinking fund for this series at the Redemption Prices for redemption through operation of the sinking fund (expressed as percentages
of the principal amount) set forth in the table below, and (2) at any time [if applicable, insert - on or after _________,
20__], as a whole or in part, at the election of the Issuer, at the Redemption Prices for redemption otherwise than through operation
of the sinking fund (expressed as percentages of the principal amount, with the amount in excess of 100% of the principal amount being
interest) set forth in the table below: If redeemed during the 12-month period beginning ____________________ of the years indicated,


 


	Year	Redemption Price For

 Redemption Through 

Operation of the 

Sinking Fund	Redemption Price For

 Redemption Otherwise 

Than Through Operation of

 the Sinking Fund


 






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and thereafter at a Redemption Price equal to
_______% of the principal amount, together in the case of any such redemption (whether through operation of the sinking fund or otherwise)
with accrued interest to the Redemption Date, but interest instalments whose Stated Maturity is on or prior to such Redemption Date will
be payable to the Holders of such Securities, or one or more Predecessor Securities, of record at the close of business on the relevant
Record Dates referred to on the face hereof, all as provided in the Indenture.]


 


[If applicable, insert
- Notwithstanding the foregoing, the Issuer may not, prior to ____________________, redeem any Securities of this series as contemplated
by [If applicable, insert - Clause (2) of] the preceding paragraph as a part of, or in anticipation of, any refunding operation
by the application, directly or indirectly, of moneys borrowed having an interest cost to the Issuer (calculated in accordance with generally
accepted financial practice) of less than ______% per annum.]


 


[If
applicable, insert - The sinking fund for this series provides for the redemption on ____________________ in each year beginning with
the year ______and ending with the year ______ of [if applicable, insert - not less than U.S.$         (“mandatory
sinking fund”) and not more than U.S.$_________] aggregate principal amount of Securities of this series. Securities of this
series acquired or redeemed by the Issuer otherwise than through [if applicable, insert - mandatory] sinking fund payments may
be credited against subsequent [if applicable, insert - mandatory] sinking fund payments otherwise required to be made [if applicable,
insert - in the inverse order in which they become due].]


 


[If applicable, insert
- The Securities may be redeemed at the option of the Issuer, in whole but not in part, upon not less than 10 nor more than 60 days’
notice given as provided in the Indenture, at any time at a Redemption Price equal to the principal amount thereof plus accrued interest
to the date fixed for redemption if:


 


(a) as a result of a change in or any amendment to the laws or any regulations
or rulings promulgated thereunder of the Relevant Taxing Jurisdiction of the Issuer or the Guarantor or of any political subdivision or
taxing authority thereof or therein (or in the case of a successor Person to the Issuer or the Guarantor, or any Subsidiary, of the jurisdiction
in which such successor Person or Subsidiary is resident for tax purposes (and, if such successor Person or Subsidiary is, or is treated
as, a “domestic corporation” for U.S. federal income tax purposes, such successor Person shall be treated as a “resident”
of the United States for U.S. federal income tax purposes ) or any political subdivision or taxing authority thereof or therein), or any
change in an application or interpretation of such laws, regulations or rulings, or any change in an application or interpretation of,
or any execution of or amendment to, any treaty or treaties affecting taxation to which such jurisdiction described above or any political
subdivision thereof (or such other jurisdiction or any political subdivision thereof) is a party, which change, amendment, application,
interpretation or execution becomes effective on or after ____________________ (or, in the case of a successor Person to the Issuer or
the Guarantor, as applicable, the date on which such successor Person became such pursuant to the applicable provision of the Indenture);
or




 


(b) as a result of any
action taken by any taxing authority of, or any action brought in a court of competent jurisdiction in, such jurisdiction described above
or any political subdivision thereof (whether or not such action was taken or brought with respect to the Issuer or the Guarantor), on
or after ____________________ (or, in the case of a successor Person to the Issuer or the Guarantor, as applicable, the date on which
such successor Person became such pursuant to the applicable provision of the Indenture); or


 






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(c) as a result of any
delivery or of any requirement to deliver definitive Registered Securities (having used all reasonable efforts to avoid having to issue
such definitive Registered Securities),


 


(i) any of the Issuer
(or such successor Person) or the Guarantor (or such successor Person) is or would be required to pay additional amounts with respect
to the Securities, on the next succeeding Interest Payment Date as set forth below; or


 


(ii) any Subsidiary of
the Issuer or the Guarantor is or would be required to deduct or withhold tax on any payment to the Issuer or the Guarantor to enable
the Issuer or the Guarantor to make any payment of principal or interest in respect of the Securities and, in each case, the payment of
such additional amounts in the case of (i) above or such deduction or withholding in the case of (ii) above cannot be avoided
by the use of any reasonable measures available to the Issuer, the Guarantor or the Subsidiary.]


 


[If applicable, insert
- The Securities may also be redeemed in whole but not in part upon not less than 10 nor more than 60 days’ notice given as
provided in the Indenture at any time at a Redemption Price equal to the principal amount thereof plus accrued interest to the date fixed
for redemption if the Person formed by a consolidation of the Issuer or Guarantor, as applicable, or into which the Issuer or Guarantor,
as applicable, is merged or to which the Issuer or the Guarantor, as applicable, conveys, transfers or leases its properties and assets
substantially as an entirety is required to pay a Holder additional amounts in respect of any tax, assessment or governmental charge which
is imposed on any such Holder or required to be withheld or deducted from any payment to such Holder as a consequence of such consolidation,
merger, conveyance, transfer or lease.]


 


[If applicable, insert
- the Redemption Price of the Securities shall be equal to the applicable percentage of the principal amount at Stated Maturity set
forth below:


 


	
    If Redemption During the

12-Month Period Commencing
	
    Redemption

Price



 


together with, in each case (except if the Redemption
Date shall be a ________), an amount equal to the applicable Redemption Price multiplied by a fraction the numerator of which is the number
of days from but not including the preceding ____________________ to and including the Redemption Date multiplied by the difference between
the Redemption Price applicable during the 12 months beginning on the ____________________ following the Redemption Date (or, in the case
of a Redemption Date after _________, 100%) and the Redemption Price applicable on the Redemption Date and the denominator of which is
the total number of days from but not including the _________ preceding the Redemption Date to and including the next succeeding _________.
The Issuer will also pay to each eligible Holder, or make available for payment to each such Holder, on the Redemption Date any additional
interest (as set forth [on the face hereof or] in the Guaranty endorsed hereon) resulting from the payment of such Redemption Price.]


 






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[If applicable, insert
- The Redemption Price of the Securities either in the event of certain changes in the tax treatment or in an event of default would
include, in addition to the face amount of the Security, an amount equal to the Original Issue Discount accrued since the issue date.
Original Issue Discount (the difference between the Issue Price and the Principal Amount at Maturity of the Security), in the period during
which a Security remains outstanding, shall accrue at _______% per annum, on a semi-annual bond equivalent basis using a 360-day year
composed of twelve 30-day months, commencing on the Issue Date of this Security.]


 


[If applicable, insert
- Notice of redemption will be given to Holders of Securities, not less than 10 nor more than 60 days prior to the date fixed for
redemption, all as provided in the Indenture.]


 


[If applicable, if the
Security is subject to redemption of any kind, insert - In the event of redemption of this Security in part only, a new Security or
Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the
cancellation hereof.]


 


[If applicable, insert
- The Indenture contains provisions for defeasance at any time of the entire indebtedness on this Security upon compliance by the
Issuer with certain conditions set forth thereon, which provisions apply to this Security.]


 


[If applicable, insert
- Subject to and upon compliance with the provisions of the Indenture, the Holder of this Security is entitled at his option, at any
time after ____________________, to convert this Security into [Describe Securities and conversion mechanics].]


 


[If applicable, insert
- In the event of conversion of this Security in part only, a new Security or Securities of this series and of like tenor for the
unconverted portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof.]


 


[If the Security is not
an Original Issue Discount Security, insert - If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided
in the Indenture.]


 


[If the Security is an
Original Issue Discount Security, insert - If an Event of Default with respect to Securities of this series shall occur and be continuing,
an amount of principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in
the Indenture. Such amount shall be equal to - insert formula for determining the amount. Upon payment (i) of the amount of
principal so declared due and payable and (ii) of interest on any overdue principal, premium and interest (in each case to the extent
that the payment of such interest shall be legally enforceable), all of the Issuer’s obligations in respect of the payment of the
principal of and interest, if any, on the Securities of this series shall terminate.]


 






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[If not applicable, delete
- If any deduction or withholding for any present or future taxes, levies, imposts or other governmental charges whatsoever imposed,
assessed, levied or collected by or for the account of the Relevant Taxing Jurisdiction of the Issuer or the Guarantor (as applicable)
or any political subdivision or taxing authority thereof or therein shall at any time be required by such jurisdiction (or any such political
subdivision or taxing authority) in respect of any amounts to be paid by the Issuer or the Guarantor under the Securities, the Issuer
or the Guarantor, as applicable, will (subject to compliance by the Holders of such Securities with any administrative requirements) pay
such additional amounts as may be necessary in order that the net amounts paid to the Holders after such deduction or withholding, shall
be not less than the amounts specified in the Securities to which such Holders are entitled had no such withholding or deduction been
required; provided, however, that neither the Issuer nor the Guarantor shall be required to make any payment of additional amounts for
or on account of:


 


(1)             any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but
for the fact that the Holder of the relevant Security (or a fiduciary, settlor, beneficiary, member or shareholder of, or possessor of
a power over, such Holder, if such Holder is an estate, trust, partnership or corporation) is or has been a domiciliary, national or resident
of, or is or has been engaged in a trade or business in, or maintains or has maintained a permanent establishment in, or is or has been
physically present in, the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein or otherwise
has or has had some connection with the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein
other than the holding or ownership of the Security, or the collection of principal, premium or interest, if any, on, or the enforcement
of, the Security;


 


(2)           any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected
but for the fact that, where presentation is required, the relevant Security was presented more than thirty days after the date on which
such payment became due or was provided for, whichever is later;


 


(3)           any
estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other governmental charge;


 


(4)           any
present or future tax, levy, impost or other governmental charge which is payable otherwise than by deduction or withholding from payments
on or in respect of the relevant Security;


 


(5)           any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected
but for the failure of the Holder or beneficial owner of the relevant Security to comply with any certification, identification or
other reporting requirements concerning the Holder’s or the beneficial owner’s nationality, residence, identity or
connection with the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein, if compliance
is required by treaty or by statute, regulation or administrative practice of such jurisdiction or of any such political subdivision
or taxing authority thereof or therein as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;


 


(6)           any
present or future tax, levy, impost or other governmental charge which the Holder would have been able to avoid by authorizing the paying
agent to report information in accordance with the procedure laid down by the relevant tax authority or by producing, in the form requested
by the relevant tax authority, a declaration, claim, certificate, document or other evidence establishing exemption therefrom;


 


(7)           any
present or future tax, levy, impost or other governmental charge which is required by Sections 1471 through 1474 (“FATCA”)
of the Internal Revenue Code of 1986, as amended (the “Code”), any current or future U.S. Treasury regulations or rulings
promulgated thereunder, any intergovernmental agreement between the United States and any other jurisdiction to implement FATCA (an “IGA”),
any law, regulation or other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S.
Internal Revenue Service under or with respect to FATCA;


 






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(8)           any
present or future tax, levy, impost or other governmental charge which is imposed or withheld because the Holder of the Security is (1) considered
a 10% shareholder (within the meaning of Sections 871(h)(3) or 881(c)(3) of the Code) of the issuer of the Security or (2) a
controlled foreign corporation related (within the meaning of Section 864(d)(4) of the Code) to the issuer of the Security;


 


(9)           any
present or future tax, levy, impost or other governmental charge which is imposed because the Holder (1) is a bank purchasing the
Security in the ordinary course of its lending business or (2) is a bank that is neither (A) buying the Security for investment
purposes only nor (B) buying the Security for resale to a third party that either is not a bank or will hold the Security for investment
purposes only;


 


(10)         any
present or future tax, levy, impost or other governmental charge which is imposed, assessed, levied or collected in respect of a payment
under or with respect to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the
sole beneficial owner of such payment or Security to the extent that the beneficiary or settlor with respect to the fiduciary, member
of that partnership or beneficial owner would not have been entitled to the additional amounts or would not have been subject to such
tax, levy, impost or charge had that beneficiary, settlor, member or beneficial owner been the actual Holder of such Security; or


 


(11)         any
combination of items (1) through (10) above,


 


nor shall additional amounts be paid in the event
that the obligation to pay additional amounts is the result of the issuance of definitive Registered Securities to a Holder of a Predecessor
Security at such Holder’s request upon the occurrence of an Event of Default and at the time payment is made definitive Registered
Securities have not been issued in exchange for the entire principal amount of the Predecessor Securities. The foregoing provisions shall
apply mutatis mutandis to any withholding or deduction for or on account of any present or future taxes, levies, imposts or other governmental
charges of whatever nature of any jurisdiction in which any successor Person to the Issuer or the Guarantor is resident for tax purposes
(and, if such successor Person is, or is treated as, a “domestic corporation” for U.S. federal income tax purposes, such successor
Person shall be treated as a “resident” of the United States for U.S. federal income tax purposes), or any political subdivision
or taxing authority thereof or therein.]


 


The Indenture permits, with
certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the
Guarantor and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer,
the Guarantor and the Trustee with the consent of the Holders of a majority in principal amount of the Securities at the time Outstanding
of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount
of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance
by the Issuer and/or the Guarantor with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.
Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether
or not notation of such consent or waiver is made upon this Security.


 






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As set forth in, and subject
to, the provisions of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect
to the Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount of
the Outstanding Securities of this series shall have made written request, and offered indemnity and/or security satisfactory to the Trustee,
to the Trustee to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal
of the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; provided, however, that such limitations do not apply to a suit instituted by the Holder hereof for the enforcement
of payment of the principal [(and premium, if any)] or [any] interest on this Security on or after the respective due dates expressed
herein [If applicable, insert - or to a suit instituted by the Holder hereof for the enforcement of the right to convert this Security
in accordance with the Indenture].


 


No reference herein to the
Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute
and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin
or currency, herein prescribed or to convert this Security as provided in the Indenture.


 


[No service charge shall be
made for any such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover
any tax or other governmental charge payable in connection therewith.]


 


The Indenture and the Securities
shall be governed by and construed in accordance with the laws of the State of New York.


 


All terms used in this Security
which are defined in the Indenture shall have the meanings assigned to them in the Indenture.


 


SCHEDULE A


 


SCHEDULE OF PRINCIPAL AMOUNT


 


The
initial principal amount of this Security shall be $     .


 


The following decreases/increases
in the principal amount of this Security have been made:


 


	Date of 

Decrease/Increase	 	Decrease in

 Principal Amount	 	Increase in

 Principal Amount	 	Total Principal

 Amount
 Following such

 Decrease/Increase	 	Notation Made by

 on Behalf of

 Trustee
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 



 






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Section 2.03         Form of
Registered Security.


 


[Form of Face of Registered Security]


 


[Insert any legend required
by the Internal Revenue Code and the regulations thereunder.]


 


ASTRAZENECA FINANCE LLC

[Title of Security]


 


	No.         ____________________	CUSIP NO.



 


AstraZeneca
Finance LLC, a Delaware limited liability company (herein called the “Issuer,” which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to ____________________, or registered assigns,
the principal sum of ____________________ on ____________________ [if the Security is to bear interest prior to Maturity, insert -,
and to pay interest thereon from _________, 20 ____ or from the most recent Interest Payment Date to which interest has been paid or duly
provided for, semi-annually in arrears on           and          in
each year] [annually in arrears on ____________________in each year], commencing _________, 20 ____, at the rate of ______% per annum,
until the principal hereof is paid or made available for payment [if applicable, insert -; provided that any principal and premium,
and any such instalment of interest, which is overdue shall bear interest at the rate of _____% per annum (to the extent that the payment
of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment,
and such interest shall be payable on demand.] The interest so payable, and punctually paid or duly provided for, on any Interest Payment
Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is
registered at the close of business on the Regular Record Date for such interest which shall be the _________ [or _________] (whether
or not a Business Day) [, as the case may be,] next preceding such Interest Payment Date. Any such interest not so punctually paid or
duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in
whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the
payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not
less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements
of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange,
all as more fully provided in said Indenture].


 






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[If the Security is not
to bear interest prior to Maturity, insert - The principal of this Security shall not bear interest except in the case of a default
in payment of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue
premium shall bear interest at the rate of _________% per annum (to the extent that the payment of such interest shall be legally enforceable),
from the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable
on demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of ____%
per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until
the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.]


 


Payment of the principal of
[(and premium, if any)] and [if applicable, insert - any such] interest on this Security will be made at the office or agency of
the Issuer maintained for that purpose in ________, in [such coin or currency of the United States of America as at the time of payment
is legal tender for payment of public and private debts] [If Security is denominated and payable in United States dollars insert currency
and method of payment] [if applicable, insert - ; provided, however, that a the option of the Issuer payment of interest may
be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register].


 


Reference is hereby made to
the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same
effect as if set forth at this place.


 


[All terms used in this Security
which are defined in the Indenture shall have the meanings assigned to them in the Indenture.]


 


Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof, by manual or pdf or other electronic image scan
signature of the Trustee created on an electronic platform (such as DocuSign) or by digital signing (such as Adobe Sign) of an authorized
signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.


 


IN WITNESS WHEREOF, the Issuer
has caused this instrument to be duly executed manually or in facsimile or by electronic image scan signature.


 


Dated:


 


	 	AstraZeneca Finance LLC
	 	 	 
	 	By:	 
	 	 	 
	 		Name:
	 	 	 
	 		Title:



 


[Form of Reverse of Registered Security]


 






    17


     


    

 


This Security is one of a
duly authorized issue of securities of the Issuer (herein called the “Securities”), issued and to be issued in one
or more series under an Indenture, dated as of                     ,
2021 (herein called the “Indenture” which term shall have the meaning assigned to it in such instrument), among the
Issuer, the Guarantor and The Bank of New York Mellon, as Trustee (herein called the “Trustee,” which term includes
any other successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Issuer, the Guarantor, the Trustee and the Holders of the Securities and
of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated
on the face hereof [, limited in aggregate principal amount to U.S.$ _________].


 


[If applicable, insert
- The Securities of this series are subject to redemption upon not less than 10 nor more than 60 days’ notice as provided in the
Indenture, [if applicable, insert – (1) on ____________________ in any year commencing with the year _______ and ending
with the year _________ through operation of the sinking fund for this series at a Redemption Price equal to [insert formula for determining
amount] (with the amount in excess of 100% of the principal amount being additional interest), and (2)] at any time [if applicable,
insert - on or after _________, 20______], as a whole or in part, at the election of the Issuer, at the following Redemption Prices
(expressed as percentages of the principal amount): If redeemed [if applicable, insert - on or before ____________________, _______%,
and if redeemed] during the 12-month period beginning ____________________of the years indicated,


 


	Year	Redemption Price	Year	Redemption Price


 


and thereafter at a Redemption Price equal to
________% of the principal amount, together in the case of any such redemption [if applicable, insert - (whether through operation
of the sinking fund or otherwise)] with accrued interest to the Redemption Date, but interest instalments whose Stated Maturity is on
or prior to such Redemption Date will be payable to the Holders of such Securities, or one or more Predecessor Securities, of record at
the close of business on the relevant Record Dates referred to on the face hereof, all as provided in the Indenture.]


 


[If applicable, insert
- The Securities of this series are subject to redemption upon not less than 10 nor more than 60 days’ notice as provided in the
Indenture, (1) on ____________________in any year commencing with the year _____ and ending with the year _____, through operation
of the sinking fund for this series at the Redemption Prices for redemption through operation of the sinking fund (expressed as percentages
of the principal amount) set forth in the table below, and (2) at any time [if applicable, insert - on or after _________,
20 _____], as a whole or in part, at the election of the Issuer, at the Redemption Prices for redemption otherwise than through operation
of the sinking fund (expressed as percentages of the principal amount, with the amount in excess of 100% of the principal amount being
additional interest) set forth in the table below: If redeemed during the 12-month period beginning ____________________of the years indicated,


 






    18


     


    

 


	Year	Redemption Price For 

Redemption Through 

Operation of the 

Sinking Fund	Redemption Price For

 Redemption Otherwise 

Than Through Operation 

of the Sinking Fund


 


and thereafter at a Redemption Price equal to
_______% of the principal amount, together in the case of any such redemption (whether through operation of the sinking fund or otherwise)
with accrued interest to the Redemption Date, but interest instalments whose Stated Maturity is on or prior to such Redemption Date will
be payable to the Holders of such Securities, or one or more Predecessor Securities, of record at the close of business on the relevant
Record Dates referred to on the face hereof, all as provided in the Indenture.]


 


[If applicable, insert
- Notwithstanding the foregoing, the Issuer may not, prior to ____________________, redeem any Securities of this series as contemplated
by [If applicable, insert - Clause (2) of] the preceding paragraph as a part of, or in anticipation of, any refunding operation
by the application, directly or indirectly, of moneys borrowed having an interest cost to the Issuer (calculated in accordance with generally
accepted financial practice) of less than _______% per annum.]


 


[If applicable, insert
- The sinking fund for this series provides for the redemption on ____________________in each year beginning with the year _________and
ending with the year _________ of [if applicable, insert - not less than U.S.$ _________(“mandatory sinking fund”)
and not more than U.S.$ _________] aggregate principal amount of Securities of this series. Securities of this series acquired or redeemed
by the Issuer otherwise than through [if applicable, insert - mandatory] sinking fund payments may be credited against subsequent
[if applicable, insert - mandatory] sinking fund payments otherwise required to be made [if applicable, insert - in the
inverse order in which they become due].]


 


[If applicable, insert
- The Securities may be redeemed at the option of the Issuer, in whole but not in part, upon not less than 10 nor more than 60 days’
notice given as provided in the Indenture, at any time at a Redemption Price equal to the principal amount thereof plus accrued interest
to the date fixed for redemption if:


 


(a) as a result of
a change in or any amendment to the laws or any regulations or rulings promulgated thereunder of the Relevant Taxing Jurisdiction of
the Issuer or the Guarantor or of any political subdivision or taxing authority thereof or therein (or in the case of a successor
Person to the Issuer or the Guarantor, or any Subsidiary, of the jurisdiction in which such successor Person or Subsidiary is
resident for tax purposes (and, if such successor Person or Subsidiary is, or is treated as, a “domestic corporation”
for U.S. federal income tax purposes, such successor Person shall be treated as a “resident” of the United States for
U.S. federal income tax purposes) or any political subdivision or taxing authority thereof or therein) or any change in an
application or interpretation of such laws, regulations or rulings, or any change in an application or interpretation of, or any
execution of or amendment to, any treaty or treaties affecting taxation to which such jurisdiction described above or any political
subdivision thereof (or such other jurisdiction or political subdivision thereof) is a party, which change, amendment, application,
interpretation or execution becomes effective on or after ____________________ (or, in the case of a successor Person to the Issuer
or the Guarantor, as applicable, the date on which such successor Person became such pursuant to the applicable provision of the
Indenture); or


 






    19


     


    

 


(b) as a result of any
action taken by any taxing authority of, or any action brought in a court of competent jurisdiction in, such jurisdiction or any political
subdivision thereof (whether or not such action was taken or brought with respect to the Issuer or the Guarantor), on or after ____________________
(or, in the case of a successor Person to the Issuer or the Guarantor, as applicable, the date on which such successor Person became such
pursuant to the applicable provision of the Indenture); or


 


(c) as a result of any
delivery or of any requirement to deliver definitive Registered Securities (having used all reasonable efforts to avoid having to issue
such definitive Registered Securities),


 


(i) any of
the Issuer (or such successor Person) or the Guarantor (or such successor Person) is or would be required to pay additional amounts with
respect to the Securities, on the next succeeding Interest Payment Date as set forth below; or


 


(ii) any Subsidiary
of the Issuer or the Guarantor is or would be required to deduct or withhold tax on any payment to the Issuer or the Guarantor to enable
the Issuer or the Guarantor to make any payment of principal or interest in respect of the Securities


 


and, in each case, the payment of such
additional amounts in the case of (i) above or such deduction or withholding in the case of (ii) above cannot be avoided by
the use of any reasonable measures available to the Issuer, the Guarantor or the Subsidiary.]


 


[If applicable, insert
- The Securities may also be redeemed in whole but not in part upon not less than 10 nor more than 60 days’ notice given as provided
in the Indenture at any time at a Redemption Price equal to the principal amount thereof plus accrued interest to the date fixed for redemption
if the Person formed by a consolidation of the Issuer or Guarantor, as applicable, or into which the Issuer or Guarantor, as applicable,
is merged or to which the Issuer or the Guarantor, as applicable, conveys, transfers or leases its properties and assets substantially
as an entirety is required to pay a Holder additional amounts in respect of any tax, assessment or governmental charge which is imposed
on any such Holder or required to be withheld or deducted from any payment to such Holder as a consequence of such consolidation, merger,
conveyance, transfer or lease.]


 






    20


     


    

 


[If applicable, insert
- the Redemption Price of the Securities shall be equal to the applicable percentage of the principal amount at Stated Maturity set forth
below:


 


	If Redemption During the

12-Month Period Commencing	Redemption Price


 


together with, in each case (except if the Redemption
Date shall be a _________), an amount equal to the applicable Redemption Price multiplied by a fraction the numerator of which is the
number of days from but not including the preceding ____________________ to and including the Redemption Date multiplied by the difference
between the Redemption Price applicable during the 12 months beginning on the ____________________ following the Redemption Date (or,
in the case of a Redemption Date after ____________________, 100%) and the Redemption Price applicable on the Redemption Date and the
denominator of which is the total number of days from but not including the ____________________ preceding the Redemption Date to and
including the next succeeding ____________________. The Issuer will also pay to each eligible Holder, or make available for payment to
each such Holder, on the Redemption Date any additional interest (as set forth [on the face hereof or] in the Guaranty endorsed hereon)
resulting from the payment of such Redemption Price.]


 


[If applicable, insert
- The Redemption Price of the Securities either in the event of certain changes in the tax treatment or in an event of default would include,
in addition to the face amount of the Security, an amount equal to the Original Issue Discount accrued since the issue date. Original
Issue Discount (the difference between the Issue Price and the Principal Amount at Maturity of the Security), in the period during which
a Security remains outstanding, shall accrue at _______% per annum, on a semi-annual bond equivalent basis using a 360-day year composed
of twelve 30-day months, commencing on the Issue Date of this Security.]


 


[If applicable, insert
- Notice of redemption will be given to Holders of Securities, not less than 10 nor more than 60 days prior to the date fixed for redemption,
all as provided in the Indenture.]


 


[If applicable, if the
Security is subject to redemption of any kind, insert - In the event of redemption of this Security in part only, a new Security or
Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the
cancellation hereof.]


 


[If applicable, insert
- The Indenture contains provisions for defeasance at any time of the entire indebtedness on this Security upon compliance by the Issuer
with certain conditions set forth thereon, which provisions apply to this Security.]


 


[If applicable, insert
- Subject to and upon compliance with the provisions of the Indenture, the Holder of this Security is entitled at his option, at any time
after ____________________, to convert this Security into [Describe Securities and conversion mechanics].]


 


[If applicable, insert
- In the event of conversion of this Security in part only, a new Security or Securities of this series and of like tenor for the unconverted
portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof.]


 


[If the Security is not
an Original Issue Discount Security, insert - If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided
in the Indenture.]


 


[If the Security is an
Original Issue Discount Security, insert - If an Event of Default with respect to Securities of this series shall occur and be continuing,
an amount of principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in
the Indenture. Such amount shall be equal to - insert formula for determining the amount. Upon payment (i) of the amount of
principal so declared due and payable and (ii) of interest on any overdue principal, premium and interest (in each case to the extent
that the payment of such interest shall be legally enforceable), all of the Issuer’s obligations in respect of the payment of the
principal of and interest, if any, on the Securities of this series shall terminate.]


 






    21


     


    

 


[If not applicable, delete
- If any deduction or withholding for any present or future taxes, levies, imposts or other governmental charges whatsoever imposed, assessed,
levied or collected by or for the account of the Relevant Taxing Jurisdiction of the Issuer or the Guarantor (as applicable) or any political
subdivision or taxing authority thereof or therein shall at any time be required by such jurisdiction (or any such political subdivision
or taxing authority) in respect of any amounts to be paid by the Issuer or the Guarantor under the Securities, the Issuer or the Guarantor,
as applicable, will (subject to compliance by the Holders of such Securities with any administrative requirements) pay such additional
amounts as may be necessary in order that the net amounts paid to the Holders after such deduction or withholding, shall be not less than
the amounts specified in the Securities to which such Holders are entitled had no such withholding or deduction been required; provided,
however, that neither the Issuer nor the Guarantor shall be required to make any payment of additional amounts for or on account of:


 


(1)           any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected
but for the fact that the Holder of the relevant Security (or a fiduciary, settlor, beneficiary, member or shareholder of, or possessor
of a power over, such Holder, if such Holder is an estate, trust, partnership or corporation) is or has been a domiciliary, national
or resident of, or is or has been engaged in a trade or business in, or maintains or has maintained a permanent establishment in, or
is or has been physically present in, the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein
or otherwise has or has had some connection with the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof
or therein other than the holding or ownership of the Security, or the collection of principal, premium or interest, if any, on, or the
enforcement of, the Security;


 


(2)           any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected
but for the fact that, where presentation is required, the relevant Security was presented more than thirty days after the date on which
such payment became due or was provided for, whichever is later;


 


(3)           any
estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other governmental charge;


 


(4)           any
present or future tax, levy, impost or other governmental charge which is payable otherwise than by deduction or withholding from payments
on or in respect of the relevant Security;


 


(5)           any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected
but for the failure of the Holder or beneficial owner of the relevant Security to comply with any certification, identification or other
reporting requirements concerning the Holder’s or the beneficial owner’s nationality, residence, identity or connection with
the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein, if compliance is required by treaty
or by statute, regulation or administrative practice of such jurisdiction or of any such political subdivision or taxing authority thereof
or therein as a condition to relief or exemption from such tax, levy, impost or other governmental charge;


 






    22


     


    

 


(6)           any
present or future tax, levy, impost or other governmental charge which the Holder would have been able to avoid by authorizing the paying
agent to report information in accordance with the procedure laid down by the relevant tax authority or by producing, in the form requested
by the relevant tax authority, a declaration, claim, certificate, document or other evidence establishing exemption therefrom;


 


(7)           any
present or future tax, levy, impost or other governmental charge which is required by Sections 1471 through 1474 (“FATCA”)
of the Internal Revenue Code of 1986, as amended (the “Code”), any current or future U.S. Treasury regulations or
rulings promulgated thereunder, any intergovernmental agreement between the United States and any other jurisdiction to implement FATCA
(an “IGA”), any law, regulation or other official guidance enacted in any jurisdiction implementing FATCA or an IGA,
or any agreement with the U.S. Internal Revenue Service under or with respect to FATCA;


 


(8)           any
present or future tax, levy, impost or other governmental charge which is imposed or withheld because the Holder of the Security is (1) considered
a 10% shareholder (within the meaning of Sections 871(h)(3) or 881(c)(3) of the Code) of the issuer of the Security or (2) a
controlled foreign corporation related (within the meaning of Section 864(d)(4) of the Code) to the issuer of the Security;


 


(9)           any
present or future tax, levy, impost or other governmental charge which is imposed because the Holder (1) is a bank purchasing the
Security in the ordinary course of its lending business or (2) is a bank that is neither (A) buying the Security for investment
purposes only nor (B) buying the Security for resale to a third party that either is not a bank or will hold the Security for investment
purposes only;


 


(10)         any
present or future tax, levy, impost or other governmental charge which is imposed, assessed, levied or collected in respect of a payment
under or with respect to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the
sole beneficial owner of such payment or Security to the extent that the beneficiary or settlor with respect to the fiduciary, member
of that partnership or beneficial owner would not have been entitled to the additional amounts or would not have been subject to such
tax, levy, impost or charge had that beneficiary, settlor, member or beneficial owner been the actual Holder of such Security ; or


 


(11)         any
combination of items (1) through (10) above,


 


nor shall additional amounts be paid in the event
that the obligation to pay additional amounts is the result of the issuance of definitive Registered Securities to a Holder of a Predecessor
Security at such Holder’s request upon the occurrence of an Event of Default and at the time payment is made definitive Registered
Securities have not been issued in exchange for the entire principal amount of the Predecessor Securities. The foregoing provisions shall
apply mutatis mutandis to any withholding or deduction for or on account of any present or future taxes, levies, imposts or other governmental
charges of whatever nature of any jurisdiction in which any successor Person to the Issuer or the Guarantor is resident for tax purposes
(and, if such successor Person is, or is treated as, a “domestic corporation” for U.S. federal income tax purposes, such successor
Person shall be treated as a “resident” of the United States for U.S. federal income tax purposes), or any political subdivision
or taxing authority thereof or therein.]


 






    23


     


    

 


The Indenture permits, with
certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the
Guarantor and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer,
the Guarantor and the Trustee with the consent of the Holders of a majority in principal amount of the Securities at the time Outstanding
of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount
of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance
by the Issuer and/or the Guarantor with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.
Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether
or not notation of such consent or waiver is made upon this Security.


 


As set forth in, and subject
to, the provisions of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect
to the Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount of
the Outstanding Securities of this series shall have made written request, and offered indemnity and/or security satisfactory to the Trustee,
to the Trustee to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal
of the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; provided, however, that such limitations do not apply to a suit instituted by the Holder hereof for the enforcement
of payment of the principal [(and premium, if any)] or [any] interest on this Security on or after the respective due dates expressed
herein [If applicable, insert - or to a suit instituted by the Holder hereof for the enforcement of the right to convert this Security
in accordance with the Indenture].


 


No reference herein to the
Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute
and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin
or currency, herein prescribed or to convert this Security as provided in the Indenture.


 


[Insert if only Registered
Securities may be issued - The Securities of this series are issuable only in registered form without coupons in denominations of and
any integral multiple thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series
are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination,
as requested by the Holder surrendering the same. As provided in the Indenture and subject to certain limitations therein set forth, the
transfer of this Security is registrable in the Security Register, upon surrender of this Security for registration of transfer at the
office or agency of the Issuer in any place where the principal of and any premium and interest on this Security are payable, duly endorsed
by, or accompanied by a written instrument of transfer in form satisfactory to the Issuer and the Security Registrar duly executed by,
the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor,
of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.]


 






    24


     


    

 


[Insert if Securities of the
series may be in registered or bearer form - Title to Bearer Securities and coupons shall pass by delivery. As provided in the Indenture
and subject to certain limitations therein set forth, the transfer of Registered Securities is registrable in the Security Register, upon
surrender of a Registered Security for registration of transfer at the office or agency of the Issuer in any place where the principal
of and any premium and interest on a Registered Security are payable, duly endorsed by, or accompanied by a written instrument of transfer
in form satisfactory to the Issuer and the Security Registrar duly executed by, the Holder thereof or his attorney duly authorized in
writing, and thereupon one or more new Registered Securities of this series and of like tenor, of authorized denominations and for the
same aggregate principal amount, will be issued to the designated transferee or transferees.]


 


[No service charge shall be
made for any such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover
any tax or other governmental charge payable in connection therewith.]


 


Prior to due presentation
of this Security for registration of transfer, the Issuer, the Guarantor, the Trustee and any agent of the Issuer, the Guarantor or the
Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security
be overdue, and neither of the Issuer, the Guarantor, the Trustee nor any such agent shall be affected by notice to the contrary.


 


The Indenture and the Securities
shall be governed by and construed in accordance with the laws of the State of New York.


 


All terms used in this Security
which are defined in the Indenture shall have the meanings assigned to them in the Indenture.


 


Section 2.04         Form of
Bearer Security.


 


[Form of Face of Bearer Security]


 


ANY UNITED STATES PERSON WHO
HOLDS THIS OBLIGATION WILL BE SUBJECT TO LIMITATIONS UNDER THE UNITED STATES INCOME TAX LAWS, INCLUDING THE LIMITATIONS PROVIDED
IN SECTIONS 165(j) AND 1287(a) OF THE INTERNAL REVENUE CODE.


 


[Insert any other legend required
by the Internal Revenue Code and the regulations thereunder.]



 






    25


     


    

 



 


ASTRAZENECA FINANCE LLC

[Title of Security]


 





	No.	 	 	 	 	                      CUSIP
    NO.


 


AstraZeneca Finance LLC,
a Delaware limited liability company (herein called the “Issuer,” which term includes any successor Person under
the Indenture hereinafter referred to), for value received, hereby promises to pay to bearer upon presentation and surrender of this
Security the principal sum of ____________________ on ____________________[if the Security is to bear interest prior to Maturity,
insert -, and to pay interest thereon from ____________________, 20__ or from the most recent Interest Payment Date to which
interest has been paid or duly provided for, semi-annually in arrears on ____________________ and ____________________ in each year]
[annually in arrears on ____________________ in each year], commencing ____________________, 20__, at the rate of ____% per annum,
until the principal                                                                                          hereof is paid or made available for payment [if applicable, insert -; provided that any principal and
premium, and any such instalment of interest, which is overdue shall bear interest at the rate of __% per annum (to the extent that
the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made
available for payment, and such interest shall be payable on demand]. [If the Security is not to bear interest prior to Maturity,
insert - The principal of this Security shall not bear interest except in the case of a default in payment of principal upon
acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium shall bear
interest at the rate of ___% per annum (to the extent that the payment of such interest shall be legally enforceable), from the date
such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on
demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of ___%
per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand
until the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] Such
payments [(including premium, if any)] shall be made, subject to any laws or regulations applicable thereto and to the right of the
Issuer (limited as provided in the Indenture) to rescind the designation of any such Paying Agent, at the [main] offices of
____________________,    in ____________________,    in ____________________in ____________________,    in ____________________     and
____________________in ____________________, or at such other offices or agencies outside the United States (as defined below) as
the Issuer may designate, at the option of the Holder, by United States dollar check drawn on a bank in The City of New York or by
transfer of United States dollars to an account maintained by the payee with a bank located outside the United States] [If Security
is denominated and payable other than in United States dollars insert currency and method of payment]. [If Security is to bear
interest prior to maturity - Interest in this Security due on or before Maturity shall be payable only upon presentation and
surrender at such an office or agency of the interest coupons hereto attached as they severally mature.] No payment of principal of
[, premium, if any] or interest on, this Security shall be made at any office or agency of the Issuer in the United States or by
check mailed to any address in the United States or by transfer to an account maintained with a bank located in the United States
[If Security is denominated and payable in United States dollars, insert -; provided, however, that payment of principal
of [(and premium, if any)] and [if applicable, insert - any such] interest on this Security shall be made at the office of
the Issuer’s Paying Agent in the Borough of Manhattan, The City of New York, if (but only if) payment in United States dollars
of the full amount of such principal, [premium, if any,] or interest as the case may be, at all offices or agencies outside the
United States maintained for the purpose by the Issuer in accordance with the Indenture is illegal or effectively precluded by
exchange controls or other similar restrictions on the full repayment or receipt of such amounts in United States dollars, as
determined by the Issuer.]


 






    26


     


    

 


Reference is hereby made to
the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same
effect as if set forth at this place.


 


[All terms used in this Security
which are defined in the Indenture shall have the meanings assigned to them in the Indenture.]


 


Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent,
by manual or pdf or other electronic image scan signature of the Trustee created on an electronic platform (such as DocuSign) or by digital
signing (such as Adobe Sign) of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be
valid or obligatory for any purpose.


 


IN WITNESS WHEREOF, the Issuer
has caused this instrument to be duly executed manually or in facsimile or by electronic image scan signature.


 


Dated:


 


	 	AstraZeneca Finance LLC
	 	 
	 	By:	 
	 	 
	 	 	Name:
	 	 	Title:




 


[Form of Reverse of Bearer Security]


 


This Security is one of a
duly authorized issue of securities of the Issuer (herein called the “Securities”), issued and to be issued in one
or more series under an Indenture, dated as of                     ,
2021 (herein called the “Indenture” which term shall have the meaning assigned to it in such instrument), among the
Issuer, the Guarantor and The Bank of New York Mellon, as Trustee (herein called the “Trustee,” which term includes
any other successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Issuer, the Guarantor, the Trustee and the Holders of the Securities and
of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated
on the face hereof [,limited in aggregate principal amount to U.S.$ _________] . The Securities of this series are issuable as Bearer
Securities, with interest coupons attached, in the denomination of U.S.$ _________ [, and as Registered Securities, without coupons, in
denominations of U.S.$ _________ and any integral multiple thereof]. [As provided in the Indenture and subject to certain limitations
therein set forth, Bearer Securities and Registered Securities of this series are exchangeable for a like aggregate principal amount of
Registered Securities of this series and of like tenor of any authorized denominations, as requested by the Holder surrendering the same,
upon surrender of the Security or Securities to be exchanged, with all unmatured coupons and all matured coupons in default thereto appertaining,
at any office or agency described below where Registered Securities of this series may be presented for registration of transfer;
provided, however, that Bearer Securities surrendered in exchange for Registered Securities between a Record Date and the relevant Interest
Payment Date shall be surrendered without the coupon relating to such Interest Payment Date. Bearer Securities may not be issued in exchange
for Registered Securities.]


 






    27


     


    

 


[If applicable, insert
- The Securities of this series are subject to redemption upon not less than 10 nor more than 60 days’ notice as provided in the
Indenture [if applicable, insert - (1) on _________ in any year commencing with the year ______ and ending with the year _________
through operation of the sinking fund for this series at a Redemption Price equal to [insert formula for determining amount] (with
the amount in excess of 100% of the principal amount being additional interest), and (2)] at any time [if applicable, insert -
on or after ____________________, 20 __], as a whole or in part, at the election of the Issuer, at the following Redemption Prices (expressed
as percentages of the principal amount): If redeemed [if applicable, insert - on or before _________, __%, and if redeemed] during
the 12-month period beginning ____________________ of the years indicated,


 


	Year	Redemption Price	Year	Redemption Price
	 	 	 	 





and thereafter at a Redemption Price equal to
____% of the principal amount, together in the case of any such redemption [if applicable, insert - (whether through operation
of the sinking fund or otherwise)] with accrued interest to the Redemption Date, but interest instalments whose Stated Maturity is on
or prior to such Redemption Date will be payable only upon presentation and surrender of coupons for such interest (at an office or agency
located outside the United States, except as herein provided otherwise).]


 


[If applicable, insert
- The Securities of this series are subject to redemption upon not less than 10 nor more than 60 days’ notice as provided in the
Indenture (1) on ____________________ in any year commencing with the year ____ and ending with the year ____, through operation
of the sinking fund for this series at the Redemption Prices for redemption through operation of the sinking fund (expressed as percentages
of the principal amount) set forth in the table below, and (2) at any time [if applicable, insert - on or after ______20__],
as a whole or in part, at the election of the Issuer, at the Redemption Prices for redemption otherwise than through operation of the
sinking fund (expressed as percentages of the principal amount, with the amount in excess of 100% of the principal amount being interest)
set forth in the table below: If redeemed during the 12-month period beginning ____________________ of the years indicated,


 






    28


     


    

 


	Year	Redemption Price For

 Redemption Through 

Operation of the 

Sinking Fund	Redemption Price For

 Redemption Otherwise

 Than Through Operation 

of the Sinking Fund


 


and thereafter at a Redemption Price equal to
_______% of the principal amount, together in the case of any such redemption (whether through operation of the sinking fund or otherwise)
with accrued interest to the Redemption Date, but interest instalments whose Stated Maturity is on or prior to such Redemption Date will
be payable only upon presentation and surrender of coupons for such interest (at an office or agency located outside the United States,
except as herein provided otherwise).]


 


[If applicable, insert
- Notwithstanding the foregoing, the Issuer may not, prior to ____________________, redeem any Securities of this series as contemplated
by [If applicable, insert - Clause (2) of] the preceding paragraph as a part of, or in anticipation of, any refunding operation
by the application, directly or indirectly, of moneys borrowed having an interest cost to the Issuer (calculated in accordance with generally
accepted financial practice) of less than _______% per annum.]


 


[If applicable, insert
- The sinking fund for this series provides for the redemption on ____________________ in each year beginning with the year ________ and
ending with the year ________ of [if applicable, insert - not less than U.S.$ ________ (“mandatory sinking fund”)
and not more than U.S.$ ________] aggregate principal amount of Securities of this series. Securities of this series acquired or redeemed
by the Issuer otherwise than through [if applicable, insert - mandatory] sinking fund payments may be credited against subsequent
[if applicable, insert - mandatory] sinking fund payments otherwise required to be made [if applicable, insert - in the
inverse order in which they become due].]


 


[If applicable, insert
- The Securities may be redeemed at the option of the Issuer, in whole but not in part, upon not less than 10 nor more than 60 days’
notice given as provided in the Indenture, at any time at a Redemption Price equal to the principal amount thereof plus accrued interest
to the date fixed for redemption if:


 


(a) as a result of
a change in or any amendment to the laws or any regulations or rulings promulgated thereunder of the Relevant Taxing Jurisdiction of
the Issuer or the Guarantor or of any political subdivision or taxing authority thereof or therein (or in the case of a successor
Person to the Issuer or the Guarantor, or any Subsidiary, of the jurisdiction in which such successor Person or Subsidiary is
resident for tax purposes (and, if such successor Person or Subsidiary is, or is treated as, a “domestic corporation”
for U.S. federal income tax purposes, such successor Person shall be treated as a “resident” of the United States for
U.S. federal income tax purposes) or any political subdivision or taxing authority thereof or therein) or any change in an
application or interpretation of such laws, regulations or rulings, or any change in an application or interpretation of, or any
execution of or amendment to, any treaty or treaties affecting taxation to which such jurisdiction described above or any political
subdivision thereof (or such other jurisdiction or political subdivision thereof) is a party, which change, amendment, application,
interpretation or execution becomes effective on or after ____________________ (or, in the case of a successor Person to the Issuer
or the Guarantor, as applicable, the date on which such successor Person became such pursuant to the applicable provision of the
Indenture); or


 


(b) as a result of any
action taken by any taxing authority of, or any action brought in a court of competent jurisdiction in, such jurisdiction or any political
subdivision thereof (whether or not such action was taken or brought with respect to the Issuer or the Guarantor), on or after ____________________
(or, in the case of a successor Person to the Issuer or the Guarantor, as applicable, the date on which such successor Person became such
pursuant to the applicable provision of the Indenture); or


 






    29


     


    

 


(c) as a result of any
delivery or of any requirement to deliver definitive Registered Securities (having used all reasonable efforts to avoid having to issue
such definitive Registered Securities),


 


(i) any of
the Issuer (or such successor Person) or the Guarantor (or such successor Person) is or would be required to pay additional amounts with
respect to the Securities, on the next succeeding Interest Payment Date as set forth below; or


 


(ii) any Subsidiary
of the Issuer or the Guarantor is or would be required to deduct or withhold tax on any payment to the Issuer or the Guarantor to enable
the Issuer or the Guarantor to make any payment of principal or interest in respect of the Securities


 


and, in each case, the payment of such
additional amounts in the case of (i) above or such deduction or withholding in the case of (ii) above cannot be avoided by
the use of any reasonable measures available to the Issuer, the Guarantor or the Subsidiary.]


 


[If applicable, insert
- The Securities may also be redeemed in whole but not in part upon not less than 10 nor more than 60 days’ notice given as provided
in the Indenture at any time at a Redemption Price equal to the principal amount thereof plus accrued interest to the date fixed for redemption
if the Person formed by a consolidation of the Issuer or Guarantor, as applicable, or into which the Issuer or Guarantor, as applicable,
is merged or to which the Issuer or the Guarantor, as applicable, conveys, transfers or leases its properties and assets substantially
as an entirety is required to pay a Holder additional amounts in respect of any tax, assessment or governmental charge imposed on any
such Holder or required to be withheld or deducted from any payment to such Holder as a consequence of such consolidation, merger, conveyance,
transfer or lease.]


 


[If applicable, insert - the Redemption
Price of the Securities shall be equal to the applicable percentage of the principal amount at Stated Maturity set forth below:


 


	If Redemption During the

12-Month Period Commencing	Redemption Price


 


together with, in each case
(except if the Redemption Date shall be a _________), an amount equal to the applicable Redemption Price multiplied by a

fraction the numerator of which is the number of days from but not including the preceding ____________________ to and including the Redemption
Date multiplied by the difference between the Redemption Price applicable during the 12 months beginning on the ____________________ following
the Redemption Date (or, in the case of a Redemption Date after _________, 100%) and the Redemption Price applicable on the Redemption
Date and the denominator of which is the total number of days from but not including the ____________________ preceding the Redemption
Date to and including the next succeeding ____________________. The Issuer will also pay to each eligible Holder, or make available for
payment to each such Holder, on the Redemption Date any additional interest (as set forth [on the face hereof or] in the Guaranty endorsed
hereon) resulting from the payment of such Redemption Price.]


 






    30


     


    

 


[If applicable, insert
- The Redemption Price of the Securities either in the event of certain changes in the tax treatment or in an event of default would include,
in addition to the face amount of the Security, an amount equal to the Original Issue Discount accrued since the issue date. Original
Issue Discount (the difference between the Issue Price and the Principal Amount at Maturity of the Security), in the period during which
a Security remains outstanding, shall accrue at _______% per annum, on a semi-annual bond equivalent basis using a 360-day year composed
of twelve 30-day months, commencing on the Issue Date of this Security.]


 


[If applicable, insert
- Notice of redemption will be given by publication in an Authorized Newspaper in London and, if the Securities of this series are then
listed on [The International Stock Exchange of the United Kingdom and the Republic of Ireland] [the Luxembourg Stock Exchange] [or] any
[other] stock exchange located outside the United States and such stock exchange shall so require, in [London] [Luxembourg] [or] in any
[other] required city outside the United States or, if not practicable, elsewhere in Europe, [and by mail to Holders of Registered Securities,]
not less than 10 nor more than 60 days prior to the date fixed for redemption, all as provided in the Indenture.]


 


[If applicable, if the
Security is subject to redemption of any kind, insert - In the event of redemption of this Security in part only, a new Security or
Securities of this series and of like tenor for the unredeemed portion hereof will be issued to the Bearer hereof upon the cancellation
hereof.]


 


[If applicable, insert
- The Indenture contains provisions for defeasance at any time of the entire indebtedness on this Security upon compliance by the Issuer
with certain conditions set forth thereon, which provisions apply to this Security.]


 


[If applicable, insert
- Subject to and upon compliance with the provisions of the Indenture, the Holder of this Security is entitled at his option, at any time
after ____________________, to convert this Security into [Describe Securities and conversion mechanics].]


 


[If applicable, insert
- In the event of conversion of this Security in part only, a new Security or Securities of this series and of like tenor for the unconverted
portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof.]


 


[If the Security is not
an Original Issue Discount Security, insert - If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided
in the Indenture.]


 


[If the Security is an
Original Issue Discount Security, insert - If an Event of Default with respect to Securities of this series shall occur and be continuing,
an amount of principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in
the Indenture. Such amount shall be equal to - insert formula for determining the amount. Upon payment (i) of the amount of
principal so declared due and payable and (ii) of interest on any overdue principal, premium and interest (in each case to the extent
that the payment of such interest shall be legally enforceable), all of the Issuer’s obligations in respect of the payment of the
principal of and interest, if any, on the Securities of this series shall terminate.]


 






    31


     


    

 


[If not applicable, delete
- If any deduction or withholding for any present or future taxes, levies, imposts or other governmental charges whatsoever imposed,
assessed, levied or collected by or for the account of the Relevant Taxing Jurisdiction of the Issuer or the Guarantor (as applicable)
or any political subdivision or taxing authority thereof or therein shall at any time be required by such jurisdiction (or any such political
subdivision or taxing authority) in respect of any amounts to be paid by the Issuer or the Guarantor under the Securities, the Issuer
or the Guarantor, as applicable, will (subject to compliance by the Holders of such Securities with any administrative requirements) pay
such additional amounts as may be necessary in order that the net amounts paid to the Holders after such deduction or withholding, shall
be not less than the amounts specified in the Securities to which such Holders are entitled had no such withholding or deduction been
required; provided, however, that neither the Issuer nor the Guarantor shall be required to make any payment of additional amounts for
or on account of:


 


(1)            any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but
for the fact that the Holder of the relevant Security (or a fiduciary, settlor, beneficiary, member or shareholder of, or possessor of
a power over, such Holder, if such Holder is an estate, trust, partnership or corporation) is or has been a domiciliary, national or resident
of, or is or has been engaged in a trade or business in, or maintains or has maintained a permanent establishment in, or is or has been
physically present in, the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein or otherwise
has or has had some connection with the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein
other than the holding or ownership of the Security, or the collection of principal, premium or interest, if any, on, or the enforcement
of, the Security;


 


(2)            any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but
for the fact that, where presentation is required, the relevant Security was presented more than thirty days after the date on which such
payment became due or was provided for, whichever is later;


 


(3)            any
estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other governmental charge;


 


(4)            any
present or future tax, levy, impost or other governmental charge which is payable otherwise than by deduction or withholding from payments
on or in respect of the relevant Security;


 


(5)            any
present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but
for the failure of the Holder or beneficial owner of the relevant Security to comply with any certification, identification or other reporting
requirements concerning the Holder’s or  the beneficial owner’s nationality, residence, identity or connection
with the Relevant Taxing Jurisdiction or any political subdivision or taxing authority thereof or therein, if compliance is required by
treaty or by statute, regulation or administrative practice of such jurisdiction or of any such political subdivision or taxing authority
thereof or therein as a condition to relief or exemption from such tax, levy, impost or other governmental charge;


 






    32


     


    

 


(6)            any
present or future tax, levy, impost or other governmental charge which the Holder would have been able to avoid by authorizing the paying
agent to report information in accordance with the procedure laid down by the relevant tax authority or by producing, in the form requested
by the relevant tax authority, a declaration, claim, certificate, document or other evidence establishing exemption therefrom;


 


(7)            any
present or future tax, levy, impost or other governmental charge which is required by Sections 1471 through 1474 (“FATCA”)
of the Internal Revenue Code of 1986, as amended (the “Code”), any current or future U.S. Treasury regulations or rulings
promulgated thereunder, any intergovernmental agreement between the United States and any other jurisdiction to implement FATCA (an “IGA”),
any law, regulation or other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S.
Internal Revenue Service under or with respect to FATCA;


 


(8)            any
present or future tax, levy, impost or other governmental charge which is imposed or withheld because the Holder of the Security is (1) considered
a 10% shareholder (within the meaning of Sections 871(h)(3) or 881(c)(3) of the Code) of the issuer of the Security or (2) a
controlled foreign corporation related (within the meaning of Section 864(d)(4) of the Code) to the issuer of the Security;


 


(9)            any
present or future tax, levy, impost or other governmental charge which is imposed because the Holder (1) is a bank purchasing the
Security in the ordinary course of its lending business or (2) is a bank that is neither (A) buying the Security for investment
purposes only nor (B) buying the Security for resale to a third party that either is not a bank or will hold the Security for investment
purposes only;


 


(10)           any
present or future tax, levy, impost or other governmental charge which is imposed, assessed, levied or collected in respect of a payment
under or with respect to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the
sole beneficial owner of such payment or Security to the extent that the beneficiary or settlor with respect to the fiduciary, member
of that partnership or beneficial owner would not have been entitled to the additional amounts or would not have been subject to such
tax, levy, impost or charge had that beneficiary, settlor, member or beneficial owner been the actual Holder of such Security; or


 


(11)           any
combination of items (1) through (10) above,


 


nor shall additional amounts
be paid in the event that the obligation to pay additional amounts is the result of the issuance of definitive Registered Securities to
a Holder of a Predecessor Security at such Holder’s request upon the occurrence of an Event of Default and at the time payment is
made definitive Registered Securities have not been issued in exchange for the entire principal amount of the Predecessor Securities.
The foregoing provisions shall apply mutatis mutandis to any withholding or deduction for or on account of any present or future taxes,
levies, imposts or other governmental charges of whatever nature of any jurisdiction in which any successor Person to the Issuer or the
Guarantor is resident for tax purposes (and, if such successor Person is, or is treated as, a “domestic corporation” for U.S.
federal income tax purposes, such successor Person shall be treated as a “resident” of the United States for U.S. federal
income tax purposes),, or any political subdivision or taxing authority thereof or therein.]


 






    33


     


    

 


The Indenture permits, with
certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the
Guarantor and the rights of the Holders of the Securities of each series to be affected [and any related coupons] under the Indenture
at any time by the Issuer, the Guarantor and the Trustee with the consent of the Holders of a majority in principal amount of the Securities
at the time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages
in principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of such series
to waive compliance by the Issuer and/or the Guarantor with certain provisions of the Indenture and certain past defaults under the Indenture
and their consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and
upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or
in lieu hereof, whether or not notation of such consent or waiver is made upon this Security.


 


As set forth in, and subject
to, the provisions of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect
to the Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount of
the Outstanding Securities of this series shall have made written request, and offered indemnity and/or security satisfactory to the Trustee,
to the Trustee to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal
of the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; provided, however, that such limitations do not apply to a suit instituted by the Holder hereof for the enforcement of
payment of the principal [(and premium, if any)] or [any] interest on this Security on or after the respective due dates expressed herein
[If applicable, insert - or to a suit instituted by the Holder hereof for the enforcement of the right to convert this Security
in accordance with the Indenture].


 


No reference herein to the
Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute
and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin
or currency, herein prescribed or to convert this Security as provided in the Indenture.


 


Title to Bearer Securities
and coupons shall pass by delivery. [As provided in the Indenture and subject to certain limitations therein set forth, the transfer of
Registered Securities is registrable in the Security Register, upon surrender of a Registered Security for registration of transfer at
the office or agency of the Issuer in any place where the principal of and any premium and interest on a Registered Security are payable,
duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Issuer and the Security Registrar duly
executed by, the Holder thereof or his attorney duly authorized in writing, and thereupon one or more new Registered Securities of this
series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee
or transferees.]


 


[No service charge shall be
made for any such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover
any tax or other governmental charge payable in connection therewith.]


 






    34


     


    

 


The Issuer, the Guarantor,
the Trustee and any agent of the Issuer, the Guarantor or the Trustee may treat the bearer of a Bearer Security and any coupon appertaining
thereto, and prior to due presentation of a Registered Security for registration of transfer the Person in whose name a Registered Security
is registered, as the owner thereof for all purposes, whether or not the Security or coupon be overdue, and neither the Issuer, the Guarantor,
the Trustee nor any such agent shall be affected by notice to the contrary.


 


The Indenture and the Securities
[and any coupons] shall be governed by and construed in accordance with the laws of the State of New York.


 


All terms used in this Security
which are defined in the Indenture shall have the meanings assigned to them in the Indenture.


 


Section 2.05     Form of
Coupon.


 


[Form of Face of Coupon]


 


ANY UNITED STATES PERSON WHO HOLDS THIS OBLIGATION
WILL BE SUBJECT TO LIMITATIONS UNDER THE UNITED STATES INCOME TAX LAWS, INCLUDING THE LIMITATIONS PROVIDED IN SECTIONS 165(j) AND
1287(a) OF THE INTERNAL REVENUE CODE.


 


[Insert any other legend required
by the Internal Revenue Code and the regulations thereunder.]


 


ASTRAZENECA FINANCE LLC

[Title of Security]


 





	 	 	 	 	 	           [R     ]*
	 	 	 	 	 	 
	No.	 	 	 	 	 	 



 


Unless the Security to which
this coupon appertains shall have been called for previous redemption and payment thereof duly provided for on the date set forth hereon,
AstraZeneca Finance LLC (hereinafter called the “Issuer”) will pay to bearer, upon surrender hereof, the amount shown
hereon (together with any additional amounts in respect thereof which the Issuer may be required to pay according to the terms of said
Security and the Indenture referred to therein) at the Paying Agents set out on the reverse hereof or at such other offices or agencies
(which, except as otherwise provided in the Security to which this coupon appertains, shall be located outside the United States of America
(including the States and the District of Columbia), and its possessions (including Puerto Rico, the U.S. Virgin Islands, Guam, American
Samoa, Wake Island and the Northern Mariana Islands) (the “United States”)) as the Issuer may designate from time to
time, at the option of the Holder, [by United States dollar check drawn on a bank in The City of New York or by transfer of United States
dollars to an account maintained by the payee with a bank located outside the United States] [If Security is denominated and payable other
than in United States dollars insert currency and method of payment], being [one year’s] interest then payable on said Security.


 






    35


     


    

 


	 	AstraZeneca Finance LLC
	 	 
	 	By:	 
	 	 
	 	 	Name:
	 	 	Title:




 


 






*Insert if redeemable.


 








	[Reverse of Coupon]*
	 
	 
	 
	 
	 
	 



 


 


 






* Insert names and addresses of initial Paying Agents located outside
the United States.


 


Section 2.06     Form of
Legend for Global Registered Securities.


 


Unless otherwise specified
as contemplated by Section 3.01 for the Securities evidenced thereby, every Global Registered Security authenticated and delivered
hereunder shall bear a legend in substantially the following form:


 


THIS SECURITY IS A GLOBAL REGISTERED SECURITY
WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.


 


Section 2.07     Form of
Trustee’s Certificate of Authentication. The Trustee’s certificate of authentication on all Securities shall be in substantially
the following form:


 


This is one of the Securities
of the series designated herein and referred to in the within-mentioned Indenture.


 


	 	The Bank of New York Mellon,
	 	as Trustee
	 	 
	 	By	 
	 	 
	 	 	Authorized Signatory




 






    36


     


    

 


Section 2.08     Amount
Unlimited; Issuable in Series. The aggregate principal amount of Securities which may be authenticated and delivered under this Indenture
is unlimited.


 


The Securities may be issued
in one or more series. There shall be established in or pursuant to one or more resolutions of the Board of Directors of the Issuer (and
set forth in a Board Resolution and, to the extent established pursuant to (rather than in) such resolutions, in an Officers’ Certificate
detailing such establishment), and/or established in one or more indentures supplemental hereto, prior to the initial issuance of Securities
of any series:


 


(a)            the
title of the Securities of the series (which shall distinguish the Securities of the series from all other Securities);


 


(b)            any
limit upon the aggregate principal amount of the Securities of the series that may be authenticated and delivered under this Indenture
(except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities
of the series pursuant to Sections 2.13, 2.14, 2.16, 8.03 or 11.03);


 


(c)            the
date or dates on which the principal of the Securities of the series is payable or the method by which the date or dates shall be determined;


 


(d)            the
rate or rates at which the Securities of the series shall bear interest, if any, or, if other than on the basis of a 360-day year of twelve
30-day months, the method by which such rate shall be determined, the date or dates from which such interest shall accrue, the interest
payment dates on which such interest shall be payable and the record dates for the determination of Holders to whom interest is payable;


 


(e)            the
place or places where the principal of and any interest on Securities of the series shall be payable (if other than as provided in Section 3.03);


 


(f)             the
price or prices at which, the period or periods within which and the terms and conditions upon which Securities of the series may be redeemed,
in whole or in part, at the option of the Issuer, pursuant to any sinking fund or otherwise, including the date referred to in Section 11.06;


 


(g)            the
obligation, if any, of the Issuer to redeem, purchase or repay Securities of the series pursuant to any sinking fund or analogous provisions
or at the option of a Holder thereof and the price or prices at which and the period or periods within which and the terms and conditions
upon which Securities of the series shall be redeemed, purchased or repaid, in whole or in part, pursuant to such obligation;


 


(h)            if
other than denominations of $2,000 and any integral multiple of $1,000 in excess thereof, the denominations in which Securities of the
series shall be issuable;


 


(i)            if
other than the principal amount thereof, the portion of the principal amount of Securities of the series which shall be payable upon declaration
of acceleration of the maturity thereof pursuant to Section 4.01 or provable in bankruptcy pursuant to Section 4.02;


 


(j)            if
other than such coin or currency of the United States of America as at the time of payment is legal tender for payment of public or private
debts, the coin or currency (including any composite currency) in which payment of the principal and interest on the Securities of the
series shall be denominated or payable, the method pursuant to which payment shall be made and the manner of determining the equivalent
thereof in the currency of the United States of America for purposes of the definition of “Outstanding” in Article 1;


 






    37


     


    

 


(k)             if
the principal of or interest on the Securities of the series are to be payable, at the election of the Issuer or a Holder thereof, in
a coin or currency (including any composite currency) other than that in which the Securities are stated to be payable, the period or
periods within which, and the terms and conditions upon which, such election may be made;


 


(l)             whether
the Issuer shall be required to pay additional amounts for withholding taxes or other governmental charges and, if applicable, a related
right to an optional tax redemption for such a series of Securities;


 


(m)            if
the amounts of payments of principal or interest, if any, on the Securities of the series may be determined with reference to an index
or are otherwise not fixed on the original issue date thereof, the manner in which such amounts shall be determined;


 


(n)            the
forms of the Securities of the series;


 


(o)            any
trustees, authenticating or paying agents, transfer agents or registrars or any other agents with respect to the Securities of such series;


 


(p)            whether
the Securities of the series will be issued in whole or in part in the form of one or more Global Securities and, in such case, the Depositary
with respect to such Global Security or Securities;


 


(q)            any
addition to, deletion from or change in the Events of Default which applies to any Securities of the series and any change in the right
of the Trustee or the requisite Holders of such Securities to declare the principal amount thereof due and payable;


 


(r)             any
addition to, deletion from or change in the covenants set forth herein which applies to Securities of the series;


 


(s)             whether
the Securities of the series will be guaranteed by any Person or Persons in addition to the Guarantor and, if so, the identity of such
Person or Persons, the terms and conditions upon which such Securities shall be guaranteed by such Person or Persons and, if applicable,
the terms and conditions upon which such guarantees may be subordinated to other indebtedness of the respective additional guarantors;


 


(t)             whether
the Securities of the series will be secured by any collateral and, if so, the terms and conditions upon which such Securities shall be
secured and, if applicable, upon which such liens may be subordinated to other liens securing other indebtedness of the Issuer, the Guarantor
or any other guarantor;


 


(u)            the
exchanges, if any, on which the Securities may be listed; and


 


(v)            any
other terms of the series (which terms shall not be inconsistent with the provisions of this Indenture).


 






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All Securities of any one
series shall be substantially identical except as to denomination and except as may otherwise be provided in or pursuant to such resolution
of the Board of Directors of the Issuer or in any such indenture supplemental hereto.


 


Section 2.09     Authentication
and Delivery of Securities. At any time and from time to time after the execution and delivery of this Indenture, the Issuer may deliver
Securities of any series executed by the Issuer and the Guarantor to the Trustee for authentication, and the Trustee shall thereupon authenticate
and deliver such Securities to or upon the written order of the Issuer contained in a Company Order. In authenticating such Securities
and accepting the additional responsibilities under this Indenture in relation to such Securities the Trustee shall be entitled to receive,
and (subject to Section 5.01) shall be fully protected in relying upon:


 


(a)            any
Board Resolution, Officers’ Certificate and/or executed supplemental indenture referred to in Sections 2.01 and 2.08 by or pursuant
to which the terms of the Securities were established;


 


(b)            Officers’
Certificates of the Issuer certifying the form and terms of the Securities, stating that the form and terms of the Securities have been
established as required pursuant to Sections 2.01 and 2.08 and comply with this Indenture and covering such other matters as the Trustee
may reasonably request;


 


(c)            one
or more Opinions of Counsel, prepared in accordance with Section 10.05, to the effect that:


 


(i)            the
form or forms and terms of such Securities have been established as required pursuant to Sections 2.01 and 2.08 in conformity with the
provisions of this Indenture;


 


(ii)           such
Securities, when authenticated and delivered by the Trustee and issued by the Issuer in the manner and subject to any conditions specified
in such Opinion of Counsel, will constitute valid and binding obligations of the Issuer;


 


(iii)          all
laws and requirements in respect of the execution and delivery by the Issuer of the Securities have been complied with; and


 


(iv)          covering
such other matters as the Trustee may reasonably request; and


 


(d)            if
the Securities being issued are Original Issue Discount Securities, an Officers’ Certificate of the Issuer setting forth the Yield
to Maturity for the Securities and any other facts required to compute amounts due on acceleration, unless such Yield to Maturity and
other facts are specified in the form of the Securities.


 


Any issue of additional debt
securities that is to utilize the same ISIN, Common Code or “CUSIP” number as a debt security already issued hereunder shall
be effected in a manner and under circumstances whereby the issue of additional debt securities is treated as a “qualified reopening”
(within the meaning of United States Treasury Regulations Section 1.1275-2(k)(3), or similar successor provision, all as in effect
at the time of the further issue) of the issue of debt securities having the shared ISIN, Common Code or “CUSIP” number, as
the case may be.


 






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The Trustee shall have the
right to decline to authenticate and deliver any Securities under this Section if the Trustee, being advised by counsel, determines
that such action may not lawfully be taken by the Issuer or if the Trustee in good faith by its board of directors or board of trustees,
executive committee, or a trust committee of directors or trustees or Responsible Officers shall determine that such action would expose
the Trustee to personal liability to existing Holders.


 


Section 2.10     Execution
of Securities and Guaranty. The Securities shall be signed on behalf of the Issuer by any two officers or directors or by one officer
or director or any other authorized person designated pursuant to a Board Resolution and its secretary or any assistant secretary. The
Guaranty shall be signed on behalf of the Guarantor by any two officers or by one officer or any other authorized person designated pursuant
to a Board Resolution and its secretary or any assistant secretary. Such signatures may be the manual, electronic or facsimile or electronic
image scan signatures of the present or any future such officers. The seal of the Issuer or the Guarantor is not required to be included
on the Securities or the Guaranty, as applicable, but, if included, may be in the form of a facsimile thereof and may be impressed, affixed,
imprinted or otherwise reproduced on the Securities or the Guaranty, as applicable. Typographical and other minor errors or defects in
any such reproduction of the seal or any such signature shall not affect the validity or enforceability of any Security that has been
duly authenticated and delivered by the Trustee.


 


In case any officer or director
of the Issuer who shall have signed any of the Securities shall cease to be such officer or director before the Security so signed shall
be authenticated and delivered by the Trustee or disposed of by the Issuer, such Security nevertheless may be authenticated and delivered
or disposed of as though the person who signed such Security had not ceased to be such officer or director of the Issuer; and any Security
may be signed on behalf of the Issuer by such persons as, at the actual date of the execution of such Security, shall be the proper officers
or directors of the Issuer, although at the date of the execution and delivery of this Indenture any such person was not such an officer
or director.


 


In case any officer of the
Guarantor who shall have signed any Guaranty endorsed on the Securities shall cease to be such officer before the Security shall be authenticated
and delivered by the Trustee or disposed of by the Issuer, such Security nevertheless may be authenticated and delivered or disposed of
as though the person who signed such Guaranty had not ceased to be such officer of the Guarantor; and any Guaranty may be signed on behalf
of the Guarantor by such persons as, at the actual date of the execution of such Guaranty, shall be the proper officers of the Guarantor,
although at the date of the execution and delivery of this Indenture any such person was not such an officer.


 


Section 2.11     Certificate
of Authentication. Only such Securities as shall bear thereon a certificate of authentication substantially in the form hereinbefore
recited, executed by the Trustee by the manual or pdf or other electronic image scan signature of the Trustee created on an electronic
platform (such as DocuSign) or by digital signing (such as Adobe Sign) of one of its authorized officers, shall be entitled to the benefits
of this Indenture or be valid or obligatory for any purpose. Such certificate by the Trustee upon any Security executed by the Issuer
shall be conclusive evidence that the Security so authenticated has been duly authenticated and delivered hereunder and that the holder
is entitled to the benefits of this Indenture.


 






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Section 2.12     Denomination
and Date of Securities; Payments of Interest. The Securities shall be issuable as registered securities without coupons and in denominations
as shall be specified as contemplated by Section 2.08. In the absence of any such specification with respect to the Securities of
any series, the Securities of such series shall be issuable in denominations of $2,000 and any multiple of $1,000 in excess thereof. The
Securities shall be numbered, lettered, or otherwise distinguished in such manner or in accordance with such plan as the officers of the
Issuer executing the same may determine with the approval of the Trustee as evidenced by the execution and authentication thereof.


 


Each Security shall be dated
the date of its authentication, shall bear interest, if any, from the date and shall be payable on the dates, in each case, which shall
be specified as contemplated by Section 2.08.


 


The person in whose name any
Security of any series is registered at the close of business on any record date applicable to a particular series with respect to any
interest payment date for such series shall be entitled to receive the interest, if any, payable on such interest payment date notwithstanding
any transfer or exchange of such Security subsequent to the record date and prior to such interest payment date, except if and to the
extent the Issuer shall default in the payment of the interest due on such interest payment date for such series, in which case such defaulted
interest shall be paid to the persons in whose names Outstanding Securities for such series are registered at the close of business on
a subsequent record date (which shall be not less than five Business Days prior to the date of payment of such defaulted interest) established
by notice given by mail by or on behalf of the Issuer to the Holders of Securities not less than 15 days preceding such subsequent record
date. The term “record date” as used with respect to any interest payment date (except a date for payment of defaulted
interest) shall mean the date specified as such in the terms of the Securities of any particular series, or, if no such date is so specified,
if such interest payment date is the first day of a calendar month, the fifteenth day of the next preceding calendar month or, if such
interest payment date is the fifteenth day of a calendar month, the first day of such calendar month, whether or not such record date
is a Business Day.


 


Section 2.13     Registration,
Transfer and Exchange.


 


(a)            Global
Securities. This Section 2.13(a) shall apply only to Global Securities deposited with the Depositary unless otherwise provided
as contemplated by Section 2.08.


 


Unless the Global Security
is presented by an authorized representative of the Depositary to the Issuer or its agent for registration of transfer, exchange or payment,
and any certificate issued is registered in the name of a nominee of the Depositary and any payment is made to such nominee, any transfer,
pledge or other use of the Global Security in registered form for value or otherwise shall be wrongful since the registered owner of such
Global Security, the nominee of the Depositary, has an interest in such Global Security.


 






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Except as otherwise specified
as contemplated by Section 2.08, any Global Security shall be exchangeable for definitive Securities only as provided in this paragraph.
A Global Security shall be exchangeable pursuant to this Section 2.13 only if (a) the Depositary notifies the Issuer that it
is unwilling or unable to continue to hold such Global Security or if at any time the Depositary ceases to be a clearing agency registered
under the Securities Exchange Act of 1934, as amended, and a successor Depositary is not appointed by the Issuer, (b) there shall
have occurred and be continuing an Event of Default with respect to the Securities, or (c) at any time if the Issuer in its sole
discretion determines that the Global Securities or any of them should be exchanged for definitive Securities. The Issuer shall notify
the Trustee in writing that such exchange has taken place and that the Depositary is no longer the Holder of such Global Security, in
whole or in part. Unless and until such notice is received by the Trustee, the Trustee shall be entitled to assume that no such exchange
of Global Security for definitive Securities has occurred, and shall have no liability with respect to any payment in reliance thereon.
Any Global Security that is exchangeable pursuant to this Section 2.13 shall be exchangeable for definitive Securities in registered
form, bearing interest (if any) at the same rate or pursuant to the same formula, having the same date of issuance, redemption provisions,
if any, specified currency and other terms and of differing denominations aggregating a like amount as the Global Security so exchangeable.
Definitive Securities shall be registered in the names of the owners of the beneficial interests in such Global Security as such names
are from time to time provided by the relevant Agent Member holding interests in such Global Security (as such Agent Member is identified
from time to time by the Depositary).


 


No Global Security may be
transferred except as a whole by a nominee of the Depositary to the Depositary or another nominee of the Depositary or by the Depositary
or any such nominee to a successor of the Depositary or a nominee of such successor. Except as provided above, owners solely of beneficial
interests in a Global Security shall not be entitled to receive physical delivery of Securities in definitive form and will not be considered
the holders thereof for any purpose under this Indenture.


 


In the event that a Global
Security is surrendered for redemption in part pursuant to Section 11.02, the Issuer shall execute, the Guarantor shall endorse the
Guarantee thereon and the Trustee shall authenticate and deliver to the Depositary for such Global Security, without service charge, a
new Global Security, in a denomination equal to the unredeemed portion of the principal of the Global Security so surrendered.


 


The Agent Members shall have
no rights under this Indenture with respect to any Global Security held on their behalf by a Depositary, and such Depositary may be treated
by the Issuer, the Trustee, and any agent of the Issuer, or the Trustee as the owner of such Global Security for all purposes whatsoever.
Notwithstanding the foregoing, nothing herein shall prevent the Issuer, the Trustee, or any agent of the Issuer, or the Trustee, from
giving effect to any written certification, proxy or other authorization furnished by a Depositary or impair, as between a Depositary
and its Agent Members, the operation of customary practices governing the exercise of the rights of a holder of any Security, including
without limitation the granting of proxies or other authorization of participants to give or take any request, demand, authorization,
direction, notice, consent, waiver or other action which a Holder is entitled to give or take under this Indenture.


 






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In connection with any exchange
of interests in a Global Security for definitive Securities, as provided in this subsection (a), then without unnecessary delay but in
any event not later than the earliest date on which such interests may be so exchanged, the Issuer shall deliver to the Trustee definitive
Securities, in aggregate principal amount equal to the principal amount of such Global Security executed by the Issuer. On or after the
earliest date on which such interests may be so exchanged, such Global Security shall be surrendered by the Depositary to the Trustee,
as the Issuer’s agent for such purpose, to be exchanged, in whole or from time to time in part, for each portion of such Global
Security, an equal aggregate principal amount of definitive Securities of authorized denominations as the portion of such Global Security
to be exchanged. Any Global Security that is exchangeable pursuant to this Section 2.13 shall be exchangeable for Securities issuable
in the denominations specified as contemplated by Section 2.08 and registered in such names as the Depositary that is the Holder
of such Global Security shall direct. If a definitive Security is issued in exchange for any portion of a Global Security after the close
of business at the office or agency where such exchange occurs on any record date and before the opening of business at such office or
agency on the relevant payment date, interest payments will not be payable on such payment date in respect of such definitive Security,
but will be payable on such payment date only to the person to whom interest payments in respect of such portion of such Global Security
are payable.


 


The Depositary may grant proxies
and otherwise authorize any person, including Agent Members and persons that may hold interests through Agent Members, to take any action
which a Holder is entitled to take under this Indenture with respect to the Securities.


 


None of the Trustee, the Paying
Agent and the Security Registrar shall have any responsibility or obligation to any beneficial owner in a Global Security, an Agent Member
or other Person with respect to the accuracy of the records of the Depositary or its nominee or of any Agent Member, with respect to any
ownership interest in the Securities or with respect to the delivery to any Agent Member, beneficial owner or other Person (other than
the Depositary) of any notice (including any notice of redemption) or the payment of any amount, under or with respect to such Securities.
All notices and communications to be given to the Securityholders and all payments to be made to Securityholders under the Securities
and this Indenture shall be given or made only to or upon the order of the registered holders (which shall be the Depositary or its nominee
in the case of the Global Security). The rights of beneficial owners in the Global Security shall be exercised only through the Depositary
subject to the applicable procedures. The Trustee, the Paying Agent and the Security Registrar shall be entitled to rely and shall be
fully protected in relying upon information furnished by the Depositary with respect to its members, participants and any beneficial owners.
The Trustee, the Paying Agent and the Security Registrar shall be entitled to deal with the Depositary, and any nominee thereof, that
is the registered holder of any Global Security for all purposes of this Indenture relating to such Global Security (including the payment
of principal, premium, if any, and interest and additional amounts, if any, and the giving of instructions or directions by or to the
owner or holder of a beneficial ownership interest in such Global Security) as the sole holder of such Global Security and shall have
no obligations to the beneficial owners thereof. None of the Trustee, the Paying Agent and the Security Registrar shall have any responsibility
or liability for any acts or omissions of the Depositary with respect to such Global Security, for the records of any such depositary,
including records in respect of beneficial ownership interests in respect of any such Global Security, for any transactions between the
Depositary and any Agent Member or between or among the Depositary, any such Agent Member and/or any holder or owner of a beneficial interest
in such Global Security, or for any transfers of beneficial interests in any such Global Security.


 






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None of the Trustee, the Paying
Agent and the Security Registrar shall have any obligation or duty to monitor, determine or inquire as to compliance with any restrictions
on transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Security (including
any transfers between or among Depositary participants, Agent Members or beneficial owners in any Global Security) other than to require
delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required
by, the terms of this Indenture, and to examine the same to determine substantial compliance as to form with the express requirements
hereof.


 


(b)            The
Issuer will keep or cause to be kept at each office or agency to be maintained for the purpose as provided in Section 3.03 a register
or registers in which, subject to such reasonable regulations as it may prescribe, it will register, and will register the transfer of,
Securities as in this Article provided. Such register shall be in written form in the English language or in any other form capable
of being converted into such form within a reasonable time. At all reasonable times such register or registers shall be open for inspection
by the Trustee.


 


Upon due presentation for
registration of transfer of any Security of any series at any such office or agency to be maintained for the purpose as provided in Section 3.03,
the Issuer shall execute, the Guarantor shall endorse the Guarantee thereon and the Trustee shall authenticate and deliver in the name
of the transferee or transferees a new Security or Securities of the same series in authorized denominations for a like aggregate principal
amount.


 


Any Security or Securities
of any series may be exchanged for a Security or Securities of the same series in other authorized denominations, in an equal aggregate
principal amount. Securities of any series to be exchanged shall be surrendered at any office or agency to be maintained by the Issuer
for the purpose as provided in Section 3.03, and the Issuer shall execute, the Guarantor shall endorse the Guarantee thereon and
the Trustee shall authenticate and deliver in exchange therefor the Security or Securities of the same series which the Securityholder
making the exchange shall be entitled to receive and bearing numbers not contemporaneously outstanding.


 


All Securities presented for
registration of transfer, exchange, redemption or payment shall (if so required by the Issuer or the Trustee) be duly endorsed by, or
be accompanied by a written instrument or instruments of transfer in form satisfactory to the Issuer and the Trustee duly executed by,
the Holder or his attorney duly authorized in writing.


 


The Issuer or the Trustee
may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in connection with any exchange
or registration of transfer of Securities. No service charge shall be made for any such transaction.


 


The Issuer shall not be required
to exchange or register a transfer of (a) any Securities of any series for a period of 15 days next preceding the first mailing of
notice of redemption of Securities of such series to be redeemed, or (b) any Securities selected, called or being called for redemption
except, in the case of any Security where public notice has been given that such Security is to be redeemed in part, the portion thereof
not so to be redeemed.


 


All Securities issued upon
any registration of transfer or exchange of Securities shall be valid obligations of the Issuer, evidencing the same debt, and entitled
to the same benefits under this Indenture, as the Securities surrendered upon such registration of transfer or exchange.


 






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Section 2.14     Mutilated,
Defaced, Destroyed, Lost and Stolen Securities. In case any temporary or definitive Security (including any Global Security) shall
become mutilated, defaced or be destroyed, lost or stolen, the Issuer in its discretion may execute, and upon the written request of
any officer of the Issuer, the Trustee shall authenticate and deliver, a new Security of the same series and bearing a number not contemporaneously
outstanding, in exchange and substitution for the mutilated or defaced Security, or in lieu of and substitution for the Security so destroyed,
lost or stolen. In every case, the applicant for a substitute Security shall furnish to the Issuer and to the Trustee and any agent of
the Issuer or the Trustee such security and/or indemnity as may be required by them to indemnify and defend and to save each of them
harmless and, in every case of destruction, loss or theft, evidence to their satisfaction of the destruction, loss or theft of such Security
and of the ownership thereof.


 


Upon the issuance of any
substitute Security, the Issuer or the Trustee may require the payment of a sum sufficient to cover any tax or other governmental charge
that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith.
In case any Security which has matured or is about to mature or has been called for redemption in full shall become mutilated or defaced
or be destroyed, lost or stolen, the Issuer may instead of issuing a substitute Security, pay or authorize the payment of the same (without
surrender thereof except in the case of a mutilated or defaced Security), if the applicant for such payment shall furnish to the Issuer
and to the Trustee and any agent of the Issuer or the Trustee such security and/or indemnity as any of them may require to save each
of them harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish to the Issuer and the Trustee and
any agent of the Issuer, or the Trustee evidence to their satisfaction of the destruction, loss or theft of such Security and of the
ownership thereof.


 


Every substitute Security
of any series issued pursuant to the provisions of this Section 2.14 by virtue of the fact that any such Security is destroyed,
lost or stolen shall constitute an additional contractual obligation of the Issuer whether or not the destroyed, lost or stolen Security
shall be at any time enforceable by anyone and shall be entitled to all the benefits of (but shall be subject to all the limitations
of rights set forth in) this Indenture equally and proportionately with any and all other Securities of such series duly authenticated
and delivered hereunder. All Securities shall be held and owned upon the express condition that, to the extent permitted by law, the
foregoing provisions are exclusive with respect to the replacement or payment of mutilated, defaced or destroyed, lost or stolen Securities
and shall preclude any and all other rights or remedies notwithstanding any law or statute existing or hereafter enacted to the contrary
with respect to the replacement or payment of negotiable instruments or other securities without their surrender.


 


Section 2.15     Cancellation
of Securities; Destruction Thereof. All Securities surrendered for payment, redemption, registration of transfer or exchange, or
for credit against any payment in respect of a sinking or analogous fund, if surrendered to the Issuer, or any agent of the Issuer, or
the Trustee, shall be delivered to the Trustee for cancellation or, if surrendered to the Trustee, shall be cancelled by it in accordance
with its then customary procedures; and no Securities shall be issued in lieu thereof except as expressly permitted by any of the provisions
of this Indenture. The Trustee shall, subject to the record retention requirements of the Securities Exchange Act of 1934, as amended,
dispose of cancelled Securities held by it in accordance with its then customary procedures and upon written request of the Issuer deliver
a certificate of disposal to the Issuer. If the Issuer shall acquire any of the Securities, such acquisition shall not operate as a redemption
or satisfaction of the indebtedness represented by such Securities unless and until the same are delivered to the Trustee for cancellation.


 






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Section 2.16     Temporary
Securities. Pending the preparation of definitive Securities for any series, the Issuer may execute and the Trustee shall authenticate
and deliver temporary Securities for such series, having endorsed thereon Securities duly executed by the Issuer (printed, lithographed,
typewritten or otherwise reproduced, in each case in form satisfactory to the Trustee). Temporary Securities of any series shall be issuable
as registered Securities without coupons, of any authorized denomination, and substantially in the form of the definitive Securities
of such series but with such omissions, insertions and variations as may be appropriate for temporary Securities, all as may be determined
by the Issuer with the concurrence of the Trustee. Temporary Securities may contain such reference to any provisions of this Indenture
as may be appropriate. Every temporary Security shall be executed by the Issuer and be authenticated by the Trustee upon the same conditions
and in substantially the same manner, and with like effect, as the definitive Securities. Without unreasonable delay, the Issuer shall
execute and shall furnish definitive Securities of such series and thereupon temporary Securities of such series may be surrendered in
exchange therefor without charge at each office or agency to be maintained by the Issuer for that purpose pursuant to Section 3.03,
and the Trustee shall authenticate and deliver in exchange for such temporary Securities of such series a like aggregate principal amount
of definitive Securities of the same series of authorized denominations. Until so exchanged, the temporary Securities of any series shall
be entitled to the same benefits under this Indenture as definitive Securities of such series.


 


Section 2.17     CUSIP
Numbers. The Issuer in issuing any series of the Securities may use CUSIP, ISIN, common code or other similar numbers, if then
generally in use, and thereafter with respect to such series, the Trustee may use such numbers in any notice of redemption with respect
to such series. The Issuer shall promptly notify the Trustee in writing of any change in the CUSIP, ISIN, common code or other similar
numbers.


 


Article 3

COVENANTS OF THE ISSUER, THE GUARANTOR AND THE TRUSTEE


 


Section 3.01     Payment
of Principal and Interest. The Issuer covenants and agrees for the benefit of the Holders of each series of Securities that it will
duly and punctually pay or cause to be paid the principal of, and interest, if any, on, each of the Securities of such series at the
place or places, at the respective times and in the manner provided in such Securities. Each installment of interest on the Securities
of any series may, at the Issuer’s option, be paid by mailing checks for such interest payable to or upon the written order of
the Holders of Securities entitled thereto as they shall appear on the registry books of the Issuer; provided that payment by
wire transfer of immediately available funds shall be required with respect to principal, premium, if any, and interest on all Global
Securities and all other Securities the Holders of which shall have provided wire transfer instructions to the Issuer or the applicable
paying agent at least five Business Days prior to the applicable payment date.


 






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Section 3.02     Additional
Amounts.  Unless otherwise specified in any Board Resolution establishing the terms of Securities of a series in accordance
with Section 2.08, if any deduction or withholding for any present or future taxes, levies, imposts or other governmental charges
whatsoever imposed, assessed, levied or collected by or for the account of the Relevant Taxing Jurisdiction of the Issuer or the Guarantor
(as applicable) or any political subdivision or taxing authority thereof or therein shall at any time be required by such jurisdiction
(or any such political subdivision or taxing authority) in respect of any amounts to be paid by the Issuer or the Guarantor under the
series of Securities, the Issuer or the Guarantor, as applicable, will (subject to compliance by the Holders of such Securities
with any administrative requirements) pay such additional amounts as may be necessary in order that the net amounts paid to the Holders
after such deduction or withholding, shall be not less than the amounts specified in the Securities to which such Holders are entitled
had no such withholding or deduction been required; provided, however, that neither the Issuer nor the Guarantor shall be required to
make any payment of additional amounts for or on account of: (i) any present or future tax, levy, impost or other governmental charge
which would not have been so imposed, assessed, levied or collected but for the fact that the Holder of the relevant Security (or a fiduciary,
settlor, beneficiary, member or shareholder of, or possessor of a power over, such Holder, if such Holder is an estate, trust, partnership
or corporation) is or has been a domiciliary, national or resident of, or is or has been engaged in a trade or business in, or maintains
or has maintained a permanent establishment in, or is or has been physically present in, the Relevant Taxing Jurisdiction or any political
subdivision or taxing authority thereof or therein or otherwise has or has had some connection with the Relevant Taxing Jurisdiction
or any political subdivision or taxing authority thereof or therein other than the holding or ownership of the Security, or the collection
of principal, premium or interest, if any, on, or the enforcement of, the Security, (ii) any present or future tax, levy, impost
or other governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that, where presentation
is required, the relevant Security was presented more than thirty days after the date on which such payment became due or was provided
for, whichever is later, (iii) any estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or
other governmental charge, (iv) any present or future tax, levy, impost or other governmental charge which is payable otherwise
than by deduction or withholding from payments on or in respect of the relevant Security, (v) any present or future tax, levy, impost
or other governmental charge which would not have been so imposed, assessed, levied or collected but for the failure of the Holder or
beneficial owner of the relevant Security to comply with any certification, identification or other reporting requirements concerning
the Holder’s or the beneficial owner’s nationality, residence, identity or connection with the Relevant Taxing Jurisdiction
or any political subdivision or taxing authority thereof or therein, if compliance is required by treaty or by statute, regulation or
administrative practice of such jurisdiction or of any such political subdivision or taxing authority thereof or therein as a condition
to relief or exemption from such tax, levy, impost or other governmental charge, (vi) any present or future tax, levy, impost or
other governmental charge which the Holder would have been able to avoid by authorizing the paying agent to report information in accordance
with the procedure laid down by the relevant tax authority or by producing, in the form requested by the relevant tax authority, a declaration,
claim, certificate, document or other evidence establishing exemption therefrom, (vii) any present or future tax, levy, impost or
other governmental charge which is required by Sections 1471 through 1474 (“FATCA”) of the Internal Revenue Code of
1986, as amended (the “Code”), any current or future U.S. Treasury regulations or rulings promulgated thereunder,
any intergovernmental agreement between the United States and any other jurisdiction to implement FATCA (an “IGA”),
any law, regulation or other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S.
Internal Revenue Service under or with respect to FATCA, (viii) any present or future tax, levy, impost or other governmental charge
which is imposed or withheld because the Holder of the Security is (1) considered a 10% shareholder (within the meaning of Sections
871(h)(3) or 881(c)(3) of the Code) of the issuer of the Security or (2) a controlled foreign corporation related (within
the meaning of Section 864(d)(4) of the Code) to the issuer of the Security, (ix) any present or future tax, levy, impost
or other governmental charge which is imposed because the Holder (1) is a bank purchasing the Security in the ordinary course of
its lending business or (2) is a bank that is neither (A) buying the Security for investment purposes only nor (B) buying
the Security for resale to a third party that either is not a bank or will hold the Security for investment purposes only, (x) any
present or future tax, levy, impost or other governmental charge which is imposed, assessed, levied or collected in respect of a payment
under or with respect to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the
sole beneficial owner of such payment or Security to the extent that the beneficiary or settlor with respect to the fiduciary, member
of that partnership or beneficial owner would not have been entitled to the additional amounts or would not have been subject to such
tax, levy, impost or charge had that beneficiary, settlor, member or beneficial owner been the actual Holder of such Security; or (xi) any
combination of items (i) through (x) above, and nor shall additional amounts be paid in the event that the obligation
to pay additional amounts is the result of the issuance of definitive Registered Securities to a Holder of a Predecessor Security at such
Holder’s request upon the occurrence of an Event of Default and at the time payment is made definitive Registered Securities have
not been issued in exchange for the entire principal amount of the Predecessor Securities.


 






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At
least 5 Business Days prior to each date on which any payment under or with respect to the Securities of any series is due and payable
(unless such obligation to pay additional amounts arises after the 5th Business Day prior to the date on which payment under
or with respect to the Securities of such series is due  and payable, in which case it will be promptly thereafter), if the
Issuer or the Guarantor will be obligated to pay additional amounts with respect to such payment, the Issuer or the Guarantor, as the
case may be, will deliver to the Trustee an Officers’ Certificate stating that such additional amounts will be payable and the amounts
so payable and setting forth such other information as is necessary to enable the Trustee to pay such additional amounts to the Holders
of the Securities of such series on the payment date.




 


Section 3.03     Offices
for Payments, etc. So long as any of the Securities of any series remain Outstanding, the Issuer will maintain in the Borough
of Manhattan, The City of New York, the following for the Securities of such series (unless otherwise provided for in the Securities
of such series): an office or agency (a) where the Securities of such series may be presented for payment, (b) where the Securities
may be presented for registration of transfer and for exchange as in this Indenture provided and (c) where notices and demands to
or upon the Issuer in respect of the Securities or of this Indenture may be served. The Issuer will give to the Trustee written notice
of the location of any such office or agency and of any change of location thereof. Unless otherwise specified in accordance with Section 2.08,
the Issuer hereby initially designates the Corporate Trust Office of The Bank of New York Mellon at Corporate Trust Office, 240 Greenwich
Street, New York, NY 10286 as the office to be maintained by it for each such purpose. In case the Issuer shall fail to so designate
or maintain any such office or agency or shall fail to give such notice of the location or of any change in the location thereof, presentations
and demands may be made and notices may be served at the Corporate Trust Office.


 


The Issuer may also from
time to time designate one or more other offices or agencies where the Securities of one or more series may be presented or surrendered
for any or all such purposes or where such notices or demands may be served and may from time to time rescind such designations;
provided, however, that no such designation or rescission shall in any manner relieve the Issuer of any obligation to maintain an office
or agency in the Borough of Manhattan, The City of New York for Securities of any series for such purposes. The Issuer will give written
notice to the Trustee of any such designation or rescission and of any such change in the location of any other office or agency.


 






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Section 3.04     Appointment
to Fill a Vacancy in Office of Trustee. The Issuer, whenever necessary to avoid or fill a vacancy in the office of Trustee, will
appoint, in the manner provided in Section 5.09, a Trustee, so that there shall at all times be a Trustee with respect to each series
of Securities hereunder.


 


Section 3.05     Payment
Agents. Whenever the Issuer shall appoint a paying agent other than the Trustee with respect to the Securities of any series, it
will cause such paying agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject
to the provisions of this Section:


 


(a)            that
it will comply with the provisions of the Trust Indenture Act of 1939 applicable to it as a paying agent;


 


(b)            that
it will hold all sums received by it as such agent for the payment of the principal of or interest, if any, on the Securities of such
series (whether such sums have been paid to it by the Issuer or by any other obligor on the Securities of such series) in trust for the
benefit of the Holders of the Securities of such series or of the Trustee;


 


(c)            that
it will give the Trustee notice of any failure by the Issuer (or by any other obligor on the Securities of such series) to make any payment
of the principal of or interest on the Securities of such series when the same shall be due and payable; and


 


(d)            that
it will pay any such sums so held in trust by it to the Trustee upon the Trustee’s written request at any time during the continuance
of the failure referred to in clause (c) above.


 


The Issuer will, on each
due date of the principal of or interest, if any, on the Securities of such series, deposit or cause to be deposited with the paying
agent a sum sufficient to pay such principal or interest so becoming due, and (unless such paying agent is the Trustee) the Issuer will
promptly notify the Trustee in writing of any failure to take such action.


 


If the Issuer shall act as
paying agent with respect to the Securities of any series, it will, on or before each due date of the principal of or interest, if any,
on the Securities of such series, set aside, segregate and hold in trust for the benefit of the Holders of the Securities of such series
a sum sufficient to pay such principal or interest so becoming due. The Issuer will promptly notify the Trustee in writing of any failure
to take such action.


 


Anything in this Section to
the contrary notwithstanding, the Issuer may at any time, for the purpose of obtaining a satisfaction and discharge with respect to one
or more or all series of Securities hereunder, or for any other reason, pay or cause to be paid to the Trustee all sums held in trust
for any such series by the Issuer or any paying agent hereunder, as required by this Section, such sums to be held by the Trustee upon
the trusts herein contained.


 


Anything in this Section to
the contrary notwithstanding, the agreement to hold sums in trust as provided in this Section is subject to the provisions of Sections
9.04 and 9.05.


 






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Section 3.06     Compliance
Certificates from the Issuer. The Issuer and the Guarantor will furnish to the Trustee on or before March 31 in each year (beginning
with March 31, 2022), if Securities are then Outstanding, a brief certificate (which need not comply with Section 10.05) from
the principal executive, financial or accounting officer of each of the Issuer and the Guarantor as to his or her knowledge of the Issuer’s
or the Guarantor’s, as applicable, compliance with all of its conditions and covenants under this Indenture (such compliance to
be determined without regard to any period of grace or requirement of notice provided under this Indenture).


 


Section 3.07     Securityholders
Lists. If and so long as the Trustee shall not be the Security registrar for the Securities of any series, the Issuer will furnish
or cause to be furnished to the Trustee a list in such form as the Trustee may reasonably require of the names and addresses of the Holders
of the Securities of such series pursuant to section 312 of the Trust Indenture Act of 1939 (a) semi-annually not more than 15 days
after each record date for the payment of interest on such Securities, as hereinabove specified, as of such record date and on dates
to be determined pursuant to Section 2.08 for non-interest bearing securities in each year, and (b) at such other times as
the Trustee may request in writing, within thirty days after receipt by the Issuer of any such request as of a date not more than 15
days prior to the time such information is furnished.


 


Section 3.08     Preservation
of Information; Communication to Holders. The Trustee shall preserve, in as current a form as is reasonably practicable, the names
and addresses of Holders contained in the most recent list furnished to the Trustee as provided in Section 3.07 and the names and
addresses of Holders received by the Trustee. The Trustee may destroy any list furnished to it as provided in Section 3.07 upon
receipt of a new list so furnished.


 


The rights of Holders to
communicate with other Holders with respect to their rights under this Indenture or under the Securities, and the corresponding rights
and privileges of the Trustee, shall be as provided by the Trust Indenture Act of 1939.


 


Every Holder, by receiving
and holding Securities, agrees with the Issuer, the Guarantor and the Trustee that neither the Issuer, the Guarantor, the Trustee nor
any agent of either of them shall be held accountable by reason of any disclosure of information as to names and addresses of Holders
made pursuant to the Trust Indenture Act of 1939.


 


Section 3.09     Limitation
on Liens. (a) Nothing contained in this Indenture or in the Securities shall in any way restrict or prevent the Guarantor or
any Subsidiary of the Guarantor from incurring, assuming or guaranteeing any indebtedness; provided that the Guarantor will not itself,
and will not permit any of its Restricted Subsidiaries to, incur, assume or guarantee indebtedness for money borrowed (hereinafter in
this Article 3 referred to as “Debt”), secured by a mortgage, pledge, security interest or lien (mortgages, pledges,
security interests and liens being hereinafter in this Article 3 referred to as a “mortgage” or “mortgages”)
upon any Principal Property or upon any shares of stock of or indebtedness of any Restricted Subsidiary, without effectively providing
that the Securities (together with, if the Guarantor shall so determine, any other Debt of the Guarantor or such Restricted Subsidiary
then existing or thereafter created ranking equally with the Securities) shall be secured equally and ratably with (or prior to) such
Debt, so long as such Debt shall be so secured, except that this Section 3.09(a) shall not apply to Debt secured by:


 


(i)          mortgages
on property, shares of stock or indebtedness of any Person existing at the time such Person becomes a Restricted Subsidiary of the Guarantor;


 






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(ii)         mortgages
on property or shares of stock existing at the time of acquisition thereof or to secure the payment of all or any part of the purchase
price thereof or to secure any Debt incurred prior to, at the time of, or within twelve months after, in the case of shares of stock,
the acquisition of such shares and, in the case of property, the later of the acquisition, the completion of construction (including
any improvements on an existing property) or the commencement of commercial operation of such property, which Debt is incurred for the
purpose of financing all or any part of the purchase price thereof;


 


(iii)        mortgages
which secure Debt owing to the Guarantor or to any of its Restricted Subsidiaries by any of the Guarantor’s Restricted Subsidiaries
or the Guarantor;


 


(iv)        mortgages
existing as of                    , 2021;




 


(v)         mortgages
on any Principal Property to secure Debt incurred to finance all or part of the cost of the improvement, construction, alteration or
repair of any building, equipment or facilities or of any other improvements on, all or any part of such Principal Property, if such
Debt is incurred prior to, during, or within twelve months after completion of, such improvement, construction, alteration or repair;


 


(vi)        mortgages
on property owned or held by any Person or on shares of stock or indebtedness of any Person, in either case existing at the time such
Person is merged into or consolidated or amalgamated with either the Guarantor or a Restricted Subsidiary or at the time of a sale, lease
or other disposition of the properties of a Person as an entirety or substantially as an entirety to the Guarantor or a Restricted Subsidiary;


 


(vii)       mortgages
arising by operation of law and not securing amounts more than ninety (90) days overdue or otherwise being contested in good faith;


 


(viii)      mortgages
arising solely by operation of law over any credit balance or cash held in any account with a financial institution;


 


(ix)         rights
of financial institutions to offset credit balances in connection with the operation of cash management programs established for the
benefit of the Guarantor and/or any Restricted Subsidiary;


 


(x)          mortgages
incurred or deposits made in the ordinary course of business, including, but not limited to, (a) any mechanics’, materialmen’s,
carriers’, workmen’s, vendors’ or other like mortgages, (b) any mortgages securing amounts in connection with
workers’ compensation, unemployment insurance and other types of social security, and (c) any easements, rights-of-way, restrictions
and other similar charges;


 


(xi)         mortgages
incurred or deposits made securing the performance of tenders, bids, leases, statutory obligations, surety and appeal bonds, government
contracts, performance and return-of-money bonds and other obligations of like nature incurred in the ordinary course of business;


 






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(xii)        mortgages
securing taxes or assessments or other applicable governmental charges or levies;


 


(xiii)       any
extension, renewal or replacement (or successive extensions, renewals or replacements), in whole or in part, of any mortgage permitted
under the foregoing clauses (i) to (xii), inclusive, or of any Debt secured thereby; provided that the principal amount of Debt
secured thereby shall not exceed the principal amount of Debt so secured at the time of such extension, renewal or replacement, and that
such extension, renewal or replacement mortgage shall be limited to all or any part of the same property or shares of stock that secured
the mortgage extended, renewed or replaced (plus improvements on such property), or property received or shares of stock issued in substitution
or exchange therefor;


 


(xiv)       mortgages
in favor of the Guarantor or any Subsidiary of the Guarantor; and


 


(xv)        any
mortgages, pledges, security interests and liens in favor of the Trustee in any of its capacities hereunder.


 


The following types of transactions
shall not be deemed to create Debt secured by a mortgage within the meaning of those terms as defined above:


 


(i)           mortgages
of property of the Guarantor or any of its Restricted Subsidiaries in favor of the United States or any State thereof, or the United
Kingdom of Great Britain and Northern Ireland, or any other country, or any political subdivision of any of the foregoing, or any department,
agency or instrumentality of any of the foregoing, to secure partial, progress, advance or other payments pursuant to the provisions
of any contract or statute including, without limitation, mortgages to secure Debt of the pollution control or industrial revenue bond
type, or to secure any indebtedness incurred for the purpose of financing all or any part of the purchase price or cost of construction
of the property subject to such mortgages.


 


(b)            Notwithstanding
the provisions of clause (a) of this Section 3.09, the Guarantor or any of its Restricted Subsidiaries may incur, assume or
guarantee Debt secured by a mortgage or mortgages which would otherwise be subject to the foregoing restrictions in an aggregate amount
which, together with all other such Debt of the Guarantor and its Restricted Subsidiaries and their Attributable Debt in respect of Sale
and Lease-Back Transactions existing at such time (other than Attributable Debt in respect of Sale and Lease-Back Transactions permitted
because the Guarantor or any Restricted Subsidiary would be entitled to incur, assume or guarantee such Debt secured by a mortgage on
the property to be leased without equally and ratably securing the Securities pursuant to clause (a) of this Section 3.09 and
other than Sale and Lease-Back Transactions, the proceeds of which have been applied in accordance with clause (ii) of Section 3.10(a))
does not at the time exceed 15% of Consolidated Net Tangible Assets.


 


(c)            The
Trustee, subject to Section 5.01, shall receive an Opinion of Counsel as conclusive evidence that any transaction complies with
the provisions of this Section 3.09. The foregoing is not intended to limit the generality of Section 5.02(c).


 






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Section 3.10     Limitation
on Sale and Lease-Back. (a) The Guarantor will not itself, and it will not permit any of its Restricted Subsidiaries to, enter
into any arrangement with any Person providing for the leasing by the Guarantor or such Restricted Subsidiary of any Principal Property
(except a lease for a temporary period not to exceed three years and except for leases between the Guarantor and a Restricted Subsidiary
or between Restricted Subsidiaries) which has been or is to be sold or transferred by the Guarantor or such Restricted Subsidiary to
such Person (herein referred to as a “Sale and Lease-Back Transaction”) unless, after giving effect thereto, the aggregate
amount of all Attributable Debt with respect to all such Sale and Lease-Back Transactions plus all Debt of the Guarantor or any of its
Restricted Subsidiaries incurred, assumed or guaranteed and secured by a mortgage or mortgages (with the exception of Debt secured by
a mortgage or mortgages on property that the Guarantor or a Restricted Subsidiary would be entitled to incur, assume or guarantee without
equally and ratably securing the Securities pursuant to Section 3.09(a)) does not exceed 15% of Consolidated Net Tangible Assets.
This Section 3.10 shall not apply to any Sale and Lease-Back Transaction if:


 


(i)          the
Guarantor or such Restricted Subsidiary would be entitled to incur, assume or guarantee Debt secured by a mortgage or mortgages on the
Principal Property to be leased without equally and ratably securing the Securities pursuant to Section 3.09(a); or


 


(ii)         the
Guarantor within the twelve months preceding the sale or transfer or the twelve months following the sale or transfer, regardless of
whether such sale or transfer may have been made by the Guarantor or by any of its Restricted Subsidiaries, applies, in the case of the
sale or transfer for cash, an amount equal to the net proceeds thereof and, in the case of a sale or transfer otherwise than for cash,
an amount equal to the fair value of the Principal Property so leased at the time of entering into such arrangement (as determined by
the Board of Directors of the Guarantor), (1) to the retirement (other than any retirement of Debt owed to the Guarantor or any
of its Restricted Subsidiaries or any retirement of Debt subordinated to the Securities) of indebtedness for money borrowed, incurred
or assumed by the Guarantor or any Restricted Subsidiary which by its terms matures at, or is extendible or renewable at the option of
the obligor to, a date more than twelve months after the date of incurring, assuming or guaranteeing such Debt or (2) to investment
in any Principal Property or Principal Properties.


 


(b)            The
Trustee, subject to Section 5.01, shall receive an Opinion of Counsel as conclusive evidence that any transaction complies with
the provisions of this Section 3.10. The foregoing is not intended to limit the generality of Section 5.02(c).


 


Section 3.11     Reports
by the Issuer and the Guarantor. Each of the Issuer and the Guarantor covenants to file with the Trustee, within 15 days after the
Issuer or the Guarantor, as applicable, is required to file the same with the Commission, copies of the annual reports and of the information,
documents, and other reports which the Issuer or the Guarantor, as applicable, may be required to file with the Commission pursuant to
Sections 13 or 15(d) of the Securities Exchange Act of 1934, as amended.


 


Delivery of such reports,
information and documents to the Trustee is for informational purposes only, and the Trustee’s receipt of such reports, information
and documents shall not constitute actual or constructive knowledge or notice of any information contained therein or determinable from
information contained therein, including the Issuer’s or the Guarantor’s compliance with any of its covenants hereunder (as
to which the Trustee is entitled to rely exclusively on Officers’ Certificates).


 






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Section 3.12     Reports
by the Trustee. The Trustee shall transmit to Holders such reports concerning the Trustee and its actions under this Indenture as
may be required pursuant to the Trust Indenture Act of 1939 at the times and in the manner provided pursuant thereto.


 


Reports so required to be
transmitted at stated intervals of not more than 12 months shall be transmitted no later than 15 July in each calendar year following
the date hereof, so long as any Securities are Outstanding hereunder, and shall be dated as of a date convenient to the Trustee no more
than 60 nor less than 45 days thereto.


 


A copy of each such report
shall, at the time of such transmission to Holders, be filed by the Trustee with each securities exchange upon which any Securities are
listed, with the Commission and with the Issuer. The Issuer or the Guarantor will notify the Trustee when the Securities are listed on
any securities exchange.


 


Article 4

REMEDIES OF THE TRUSTEE AND

SECURITYHOLDERS ON EVENT OF DEFAULT


 


Section 4.01     Event
of Default Defined; Acceleration of Maturity; Waiver of Default. “Event of Default” with respect to Securities of any
series wherever used herein, means each one of the following events which shall have occurred and be continuing (whatever the reason
for such Event of Default and whether it shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment,
decree or order of any court or any order, rule or regulation of any administrative or governmental body):


 


(a)            default
in the payment of any installment of interest upon any of the Securities of such series as and when the same shall become due and payable,
and continuance of such default for a period of 30 days; or


 


(b)            default
in the payment of all or any part of the principal on any of the Securities of such series as and when the same shall become due and
payable either at maturity, upon redemption, by declaration or otherwise; or


 


(c)            default
in the payment of any sinking fund installment as and when the same shall become due and payable by the terms of the Securities of such
series or beyond any period of grace provided with respect thereto; or


 


(d)            default
in the performance or breach of any covenant or warranty of the Issuer or the Guarantor in respect of the Securities of such series (other
than a covenant or warranty in respect of the Securities of such series a default in whose performance or whose breach is elsewhere in
this Section specifically dealt with), and continuance of such default or breach for a period of 90 days after there has been given,
by registered or certified mail, to the Issuer by the Trustee or to the Issuer and the Trustee by the Holders of at least 25% in principal
amount of the Outstanding Securities of all series affected thereby, a written notice specifying such default or breach and requiring
it to be remedied and stating that such notice is a “Notice of Default” hereunder; or


 






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(e)            a
court having jurisdiction in the premises shall enter a decree or order for relief in respect of the Issuer or the Guarantor in an involuntary
case under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or appointing a receiver, liquidator,
assignee, custodian, trustee or sequestrator (or similar official) of the Issuer or the Guarantor or for any substantial part of the
property of the Issuer or the Guarantor or (other than under or in connection with a scheme of amalgamation or reconstruction not involving
bankruptcy or insolvency) ordering the winding up or liquidation of the Issuer’s or the Guarantor’s affairs, and such decree
or order shall remain unstayed and in effect for a period of 60 consecutive days; or


 


(f)             the
Issuer or the Guarantor shall institute proceedings to be adjudicated a bankrupt or insolvent, or the Issuer or the Guarantor shall consent
to the institution of bankruptcy or insolvency proceedings against itself or (other than under or in connection with a scheme of amalgamation
or reconstruction not involving bankruptcy or insolvency) the passing of a resolution that the Issuer or the Guarantor be wound up or
the filing of a petition or answer or consent seeking reorganization or relief under any applicable bankruptcy, insolvency or similar
law of the United States of America or the United Kingdom, or the consent by the Issuer or the Guarantor to the filing of such petition
or to the appointment of a receiver, liquidator, assignee, trustee, sequestrator or similar official of the Issuer or the Guarantor or
for any substantial part of the Issuer’s or the Guarantor’s property, or make any general assignment for the benefit of creditors;
or


 


(g)            the
Guaranty of the Guarantor ceases to be in full force or effect or the Guarantor denies or disaffirms its obligations under the Guaranty;
or


 


(h)            any
other Event of Default provided in the supplemental indenture or resolution of the Board of Directors of the Issuer under which such
series of Securities is issued or in the form of Security for such series.


 


If an Event of Default described
in clauses (a), (b), (c) or (d) (if the Event of Default under clause (d) is with respect to less than all series of Securities
then Outstanding), (g) or (h) above occurs and is continuing with respect to a series of Securities, then, and in each and
every such case, unless the principal of all of the Securities of such series shall have already become due and payable, either the Trustee
or the Holders of not less than 25% in aggregate principal amount of the Securities of such series then Outstanding hereunder (each such
series voting as a separate class) by notice in writing to the Issuer and the Guarantor (and to the Trustee if given by Securityholders),
may declare the entire principal (or, if the Securities of such series are Original Issue Discount Securities, such portion of the principal
amount as may be specified in the terms of such series) of all Securities of such series and the interest accrued thereon, if any, to
be due and payable immediately, and upon any such declaration the same shall become immediately due and payable. If an Event of Default
described in clauses (d) (if the Event of Default under clause (d), is with respect to all series of Securities then Outstanding),
(e) or (f) occurs and is continuing, then and in each and every such case, unless the principal of all the Securities shall
have already become due and payable, either the Trustee or the Holders of not less than 25% in aggregate principal amount of all the
Securities then Outstanding hereunder (treated as one class), by notice in writing to the Issuer and the Guarantor (and to the Trustee
if given by Securityholders), may declare the entire principal (or, if any Securities are Original Issue Discount Securities, such portion
of the principal as may be specified in the terms thereof) of all the Securities then Outstanding and interest accrued thereon, if any,
to be due and payable immediately, and upon any such declaration the same shall become immediately due and payable.


 






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The foregoing provisions,
however, are subject to the condition that if, at any time after the principal (or, if the Securities are Original Issue Discount Securities,
such portion of the principal as may be specified in the terms thereof) of the Securities of any series (or of all the Securities, as
the case may be) shall have been so declared due and payable, and before any judgment or decree for the payment of the moneys due shall
have been obtained or entered as hereinafter provided, the Issuer shall pay or shall deposit with the Trustee a sum sufficient to pay
all matured installments of interest upon all the Securities of such series (or of all the Securities, as the case may be) and the principal
of any and all Securities of such series (or of all the Securities, as the case may be) which shall have become due otherwise than by
acceleration (with interest upon such principal and, to the extent that payment of such interest is enforceable under applicable law,
on overdue installments of interest, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount
Securities) specified in the Securities of such series (or at the respective rates of interest or Yields to Maturity of all the Securities,
as the case may be) to the date of such payment or deposit) and such amount as shall be sufficient to cover reasonable compensation to
the Trustee, its agents, attorneys and counsel, and all other expenses and liabilities incurred, and all advances made, by the Trustee
except as a result of negligence, willful misconduct or bad faith, and if any and all Events of Default under this Indenture, other than
the non-payment of the principal of Securities which shall have become due by acceleration, shall have been cured, waived or otherwise
remedied as provided herein, then and in every such case the Holders of a majority in aggregate principal amount of all the Securities
of such series, each series voting as a separate class (or of all the Securities, as the case may be, voting as a single class), then
Outstanding, by written notice to the Issuer, the Guarantor and to the Trustee, may waive all defaults with respect to such series (or
with respect to all the Securities, as the case may be) and rescind and annul such declaration and its consequences, but no such waiver
or rescission and annulment shall extend to or shall affect any subsequent default or shall impair any right consequent thereon.


 


For all purposes under this
Indenture, if a portion of the principal of any Original Issue Discount Securities shall have been accelerated and declared due and payable
pursuant to the provisions hereof, then, from and after such declaration, unless such declaration has been rescinded and annulled, the
principal amount of such Original Issue Discount Securities shall be deemed, for all purposes hereunder, to be such portion of the principal
thereof as shall be due and payable as a result of such acceleration, and payment of such portion of the principal thereof as shall be
due and payable as a result of such acceleration, together with interest, if any, thereon and all other amounts owing thereunder, shall
constitute payment in full of such Original Issue Discount Securities.


 


Section 4.02     Collection
of Indebtedness by Trustee; Trustee May Prove Debt. The Issuer covenants that (a) in case default shall be made in the
payment of any installment of interest on any of the Securities of any series when such interest shall have become due and payable, and
such default shall have continued for a period of 30 days or (b) in case default shall be made in the payment of all or any part
of the principal of any of the Securities of any series when the same shall have become due and payable, whether upon maturity of the
Securities of such series or upon any redemption or by declaration or otherwise, then upon demand of the Trustee, the Issuer will pay
to the Trustee for the benefit of the Holders of the Securities of such series the whole amount that then shall have become due and payable
on all Securities of such series for principal or interest, as the case may be (with interest to the date of such payment upon the overdue
principal and, to the extent that payment of such interest is enforceable under applicable law, on overdue installments of interest at
the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities
of such series) and, in addition thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, including
reasonable compensation to the Trustee and each predecessor Trustee, their respective agents, attorneys and counsel, and any expenses
and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee except as a result of its negligence, willful
misconduct or bad faith.


 






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Until such demand is made
by the Trustee, the Issuer may pay the principal of and interest on the Securities of any series to the registered Holders, whether or
not the principal of and interest on the Securities of such series shall be overdue.


 


In case the Issuer shall
fail forthwith to pay such amounts upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled
and empowered to institute any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may prosecute
any such action or proceedings to judgment or final decree, and may enforce any such judgment or final decree against the Issuer or other
obligor upon such Securities and collect in the manner provided by law out of the property of the Issuer or other obligor upon such Securities,
wherever situated, the moneys adjudged or decreed to be payable.


 


In case there shall be pending
proceedings relative to the Issuer, the Guarantor or any other obligor upon the Securities under any applicable bankruptcy, insolvency
or other similar law, or in case a receiver, assignee or trustee in bankruptcy or reorganization, liquidator, sequestrator or similar
official shall have been appointed for or taken possession of the Issuer, the Guarantor or such other obligor on the property of the
Issuer, the Guarantor or such other obligor, or in case of any other comparable judicial proceedings relative to the Issuer, the Guarantor
or other obligor upon the Securities of any series, or to the creditors or property of the Issuer, the Guarantor or such other obligor,
the Trustee, irrespective of whether the principal of any Securities shall then be due and payable as therein expressed or by declaration
or otherwise and irrespective of whether the Trustee shall have made any demand pursuant to the provisions of this Section, shall be
entitled and empowered, by intervention in such proceedings or otherwise:


 


(a)            to
file and prove a claim or claims for the whole amount of principal and interest (or, if the Securities of any series are Original Issue
Discount Securities, such portion of the principal amount as may be specified in the terms of such series) owing and unpaid in respect
of the Securities of any series, and to file such other papers or documents as may be necessary or advisable in order to have the claims
of the Trustee (including any claim for reasonable compensation to the Trustee and each predecessor Trustee, and their respective agents,
attorneys and counsel, and for reimbursement of all expenses and liabilities incurred, and all advances made, by the Trustee and each
predecessor Trustee, except as a result of negligence, willful misconduct or bad faith) and of the Securityholders allowed in any judicial
proceedings relative to the Issuer, the Guarantor or other obligor upon the Securities of any series, or to the creditors or property
of the Issuer, the Guarantor or such other obligor,


 


(b)            unless
prohibited by applicable law and regulations, to vote on behalf of the Holders of the Securities of any series in any election of a trustee
or a standby trustee in arrangement, reorganization, liquidation or other bankruptcy or insolvency proceedings or person performing similar
functions in comparable proceedings, and


 






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(c)            to
collect and receive any moneys or other property payable or deliverable on any such claims, and to distribute all amounts received with
respect to the claims of the Securityholders and of the Trustee on their behalf; and any trustee, receiver, or liquidator, custodian
or other similar official is hereby authorized by each of the Securityholders to make payments to the Trustee, and, in the event that
the Trustee shall consent to the making of payments directly to the Securityholders, to pay to the Trustee such amounts as shall be sufficient
to cover reasonable compensation to the Trustee, each predecessor Trustee and their respective agents, attorneys and counsel, and all
other expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee except as a result of negligence,
willful misconduct or bad faith and all other amounts due to the Trustee
or any predecessor Trustee pursuant to Section 5.06.


 


Nothing herein contained
shall be deemed to authorize the Trustee to authorize or consent to or vote for or accept or adopt on behalf of any Securityholder any
plan of reorganization, arrangement, adjustment or composition affecting the Securities of any series or the rights of any Holder thereof,
or to authorize the Trustee to vote in respect of the claim of any Securityholder in any such proceeding except, as aforesaid, to vote
for the election of a trustee in bankruptcy or similar person.


 


All rights of action and
of asserting claims under this Indenture, or under any of the Securities, may be enforced by the Trustee without the possession of any
of the Securities or the production thereof on any trial or other proceedings relative thereto, and any such action or proceedings instituted
by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment, subject to the payment
of the expenses, disbursements and compensation of the Trustee, each predecessor Trustee and their respective agents and attorneys, shall
be for the ratable benefit of the Holders of the Securities in respect of which such action was taken.


 


In any proceedings brought
by the Trustee (and also any proceedings involving the interpretation of any provision of this Indenture to which the Trustee shall be
a party) the Trustee shall be held to represent all the Holders of the Securities in respect of which such action was taken, and it shall
not be necessary to make any Holders of such Securities parties to any such proceedings.


 


Section 4.03     Application
of Proceeds. Any moneys collected by the Trustee pursuant to this Article in respect of any series of Securities or, after an
Event of Default, any money or other property distributable in respect of the Issuer’s or the Guarantor’s obligations under
this Indenture shall be applied in the following order at the date or dates fixed by the Trustee and, in case of the distribution of
such money or other property on account of principal or interest, upon presentation of the several Securities in respect of which money
or other property have been collected and stamping thereon or otherwise noting the payment, or issuing Securities of such series in reduced
principal amounts in exchange for the presented Securities of like series if only partially paid, or upon surrender thereof if fully
paid:


 


FIRST: To the payment of
costs and expenses applicable to such series in respect of which monies have been collected, including reasonable compensation to the
Trustee and each predecessor Trustee and their respective agents and attorneys and of all expenses and liabilities incurred, and all
advances made, by the Trustee and each predecessor Trustee except as a result of negligence, willful
misconduct or bad faith and all other amounts due to the Trustee or any predecessor Trustee pursuant to Section 5.06.


 






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SECOND: In case the principal
of the Securities of such series in respect of which moneys have been collected shall not have become and be then due and payable, to
the payment of interest on the Securities of such series in default in the order of the maturity of the installments of such interest,
with interest (to the extent that such interest has been collected by the Trustee) upon the overdue installments of interest at the same
rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in such Securities, such
payments to be made ratably to the persons entitled thereto, without discrimination or preference;


 


THIRD: In case the principal
of the Securities of such series in respect of which moneys have been collected shall have become and shall be then due and payable,
to the payment of the whole amount then owing and unpaid upon all the Securities of such series for principal and interest, with interest
upon the overdue principal, and (to the extent that such interest has been collected by the Trustee) upon overdue installments of interest
at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities
of such series; and in case such moneys shall be insufficient to pay in full the whole amount so due and unpaid upon the Securities of
such series, then to the payment of such principal and interest or Yield to Maturity, without preference or priority of principal over
interest or Yield to Maturity, or of interest or Yield to Maturity over principal, or of any installment of interest over any other installment
of interest, or of any Security of such series over any other Security of such series, ratably to the aggregate of such principal and
accrued and unpaid interest or Yield to Maturity; and


 


FOURTH: To the payment of
the remainder, if any, to the Issuer or any other person lawfully entitled thereto.


 


Section 4.04     Suits
for Enforcement. In case an Event of Default has occurred, has not been waived and is continuing, the Trustee may in its discretion
proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial proceedings as the Trustee shall
deem most effectual to protect and enforce any of such rights, either at law or in equity or in bankruptcy or otherwise, whether for
the specific enforcement of any covenant or agreement contained in this Indenture or in aid of the exercise of any power granted in this
Indenture or to enforce any other legal or equitable right vested in the Trustee by this Indenture or by law.


 


Section 4.05     Restoration
of Rights on Abandonment of Proceedings. In case the Trustee or any Holder shall have proceeded to enforce any right under this Indenture
and such proceedings shall have been discontinued or abandoned for any reason, or shall have been determined adversely to the Trustee
or such Holder, then and in every such case the Issuer, the Guarantor, the Trustee and such Holder shall be restored respectively to
their former positions and rights hereunder, and all rights, remedies and powers of the Issuer, the Guarantor, the Trustee and the Securityholders
shall continue as though no such proceedings had been taken.


 






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Section 4.06     Limitations
on Suits by Securityholders. No Holder of any Security of any series shall have any right by virtue or by availing of any provision
of this Indenture to institute any action or proceeding at law or in equity or in bankruptcy or otherwise upon or under or with respect
to this Indenture, or for the appointment of a trustee, receiver, liquidator, custodian or other similar official or for any other remedy
hereunder, unless such Holder previously shall have given to the Trustee written notice of default and of the continuance thereof, as
hereinbefore provided, and unless also the Holders of not less than 25% in aggregate principal amount of the Securities of such series
then Outstanding shall have made written request upon the Trustee to institute such action or proceedings in its own name as trustee
hereunder and shall have offered to the Trustee such indemnity and/or security satisfactory to the Trustee as it may require against
the costs, expenses and liabilities to be incurred therein or thereby and the Trustee for 60 days after its receipt of such notice, request
and offer of indemnity and/or security shall have failed to institute any such action or proceeding and no direction inconsistent with
such written request shall have been given to the Trustee pursuant to Section 4.09; it being understood and intended, and being
expressly covenanted by the taker and Holder of every Security with every other taker and Holder and the Trustee, that no one or more
Holders of Securities of any series shall have any right in any manner whatever by virtue or by availing of any provision of this Indenture
to affect, disturb or prejudice the rights of any other such Holder of Securities, or to obtain or seek to obtain priority over or preference
to any other such Holder or to enforce any right under this Indenture, except in the manner herein provided and for the equal, ratable
and common benefit of all Holders of Securities of the applicable series. For the protection and enforcement of the provisions of this
Section, each and every Securityholder and the Trustee shall be entitled to such relief as can be given either at law or in equity.


 


Section 4.07     Unconditional
Right of Securityholders to Institute Certain Suits. Notwithstanding any other provision in this Indenture and any provision of any
Security, the right of any Holder of any Security to receive payment of the principal of and interest, if any, on such Security on or
after the respective due dates expressed in such Security, or to institute suit for the enforcement of any such payment on or after such
respective dates, shall not be impaired or affected without the consent of such Holder.


 


Section 4.08     Powers
and Remedies Cumulative; Delay or Omission Not Waiver of Default. Except as provided in Section 4.06, no right or remedy herein
conferred upon or reserved to the Trustee or to the Securityholders is intended to be exclusive of any other right or remedy, and every
right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right and remedy given hereunder
or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise,
shall not prevent the concurrent assertion or employment of any other appropriate right or remedy.


 


No delay or omission of the
Trustee or of any Securityholder to exercise any right or power accruing upon any Event of Default occurring and continuing as aforesaid
shall impair any such right or power or shall be construed to be a waiver of any such Event of Default or an acquiescence therein; and,
subject to Section 4.06, every power and remedy given by this Indenture or by law to the Trustee or to the Securityholders may be
exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by the Securityholders.


 






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Section 4.09     Control
by Securityholders. The Holders of a majority in aggregate principal amount of the Securities of each series affected (with each
series voting as a separate class) at the time Outstanding shall have the right to direct the time, method, and place of conducting any
proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee with respect to the Securities
of such series by this Indenture; provided that such direction shall not be otherwise than in accordance with law and the provisions
of this Indenture and provided further that the Trustee shall have the right to decline to follow any such direction if the Trustee,
being advised by counsel, shall determine that the action or proceeding so directed may not lawfully be taken or if the Trustee shall
determine that the action or proceedings so directed would involve the Trustee in personal liability or would be unduly prejudicial to
the interests of Holders of the Securities of all series so affected not joining in the giving of said direction, it being understood
that the Trustee shall have no duty to ascertain whether or not such actions or forebearances may not lawfully be taken or are unduly
prejudicial to such Holders.


 


Nothing in this Indenture
shall impair the right of the Trustee in its discretion to take any action deemed proper by the Trustee and which is not inconsistent
with such direction or directions by Securityholders.


 


Section 4.10     Waiver
of Past Defaults. Prior to the declaration of the acceleration of the maturity of the Securities of any series as provided in Section 4.01,
the Holders of a majority in aggregate principal amount of the Securities of such series at the time Outstanding may on behalf of the
Holders of all the Securities of such series waive any past default or Event of Default described in clauses (g) or (h) of
Section 4.01, or, in the case of an event specified in clause (d) of Section 4.01 (if the Event of Default under clause
(d) relates to less than all series of Securities then Outstanding), the Holders of a majority in aggregate principal amount of
the Securities of each series then Outstanding affected thereby (each series voting as a separate class) may waive any such default or
Event of Default, or, in the case of an event specified in clauses (d) (if the Event of Default under clause (d) relates to
all series of Securities then Outstanding), (e) or (f) of Section 4.01 the Holders of Securities of a majority in principal
amount of all the Securities then Outstanding (voting as one class) may waive any such default or Event of Default, and its consequences
except a default in respect of a covenant or provision hereof which cannot be modified or amended without the consent of the Holder of
each Security affected. In the case of any such waiver, the Issuer, the Guarantor, the Trustee and the Holders of the Securities of such
series shall be restored to their former positions and rights hereunder, respectively, and such default shall cease to exist and be deemed
to have been cured and not to have occurred, and any Event of Default arising therefrom shall be deemed to have been cured, and not to
have occurred for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other default or Event of Default
or impair any right consequent thereon.


 


Section 4.11     Trustee
to Give Notice of Default, but May Withhold in Certain Circumstances. The Trustee shall give to the Securityholders of any series,
as the names and addresses of such Holders appear on the registry books, notice by mail of all defaults known to the Trustee which have
occurred with respect to such series, such notice to be transmitted within 90 days after the occurrence thereof, unless such defaults
shall have been cured before the giving of such notice (the term “default” or “defaults” for the purposes of
this Section being hereby defined to mean any event or condition which is, or with notice or lapse of time or both would become,
an Event of Default); provided that, except in the case of default in the payment of the principal of or interest on any of the Securities
of such series, or in the payment of any sinking or purchase fund installment with respect to the Securities of such series, the Trustee
shall be protected in withholding such notice if and so long as the board of directors, the executive committee, or a trust committee
of directors or trustees and/or responsible officers of the Trustee in good faith determines that the withholding of such notice is in
the interests of the Securityholders of such series.


 






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Section 4.12     Right
of Court to Require Filing of Undertaking to Pay Costs. All parties to this Indenture agree, and each Holder of any Security by his
acceptance thereof shall be deemed to have agreed, that any court may in its discretion require, in any suit for the enforcement of any
right or remedy under this Indenture or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee, the
filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and that such court may in its discretion
assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having due regard to the
merits and good faith of the claims or defenses made by such party litigant; but the provisions of this Section shall not apply
to any suit instituted by the Trustee, to any suit instituted by any Securityholder or group of Securityholders of any series holding
in the aggregate more than 10% in aggregate principal amount of the Securities of such series, or, in the case of any suit relating to
or arising under clause (d) of Section 4.01 (if the suit relates to Securities of more than one but less than all series),
10% in aggregate principal amount of Securities Outstanding affected thereby, or in the case of any suit relating to or arising under
clauses (d) (if the suit relates to all the Securities then Outstanding), (e) or (f) of Section 4.01 10% in aggregate
principal amount of all Securities Outstanding, or to any suit instituted by any Securityholder for the enforcement of the payment of
the principal of or interest, if any, on any Security on or after the due date expressed in such Security.


 


Article 5

CONCERNING THE TRUSTEE


 


Section 5.01     Duties
and Responsibilities of the Trustee; During Default; Prior to Default.


 


(a)            Except
during the continuance of an Event of Default with respect to the Securities of a series:


 


(i)          the
Trustee undertakes to perform such duties and only such duties as are specifically set forth in this Indenture, and no implied covenants
or obligations shall be read into this Indenture against the Trustee; and


 


(ii)         in
the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness of the
opinions expressed therein, upon certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture;
but in the case of any such certificates or opinions which by any provision hereof are specifically required to be furnished to the Trustee,
the Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Indenture
(but need not confirm or investigate the accuracy of mathematical calculations or other facts, statements, opinions or conclusions stated
therein).


 


(b)            In
case an Event of Default with respect to the Securities of a series has occurred and is continuing, the Trustee shall exercise such of
the rights and powers vested in it by this Indenture, and use the same degree of care and skill in their exercise, as a prudent person
would exercise or use under the circumstances in the conduct of his or her own affairs.


 






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(c)            No
provision of this Indenture shall be construed to relieve the Trustee from liability for its own negligent action, its own negligent
failure to act or its own willful misconduct, except that:


 


(i)          this
Subsection (c) shall not be construed to limit the effect of Subsections (a) or (d) of this Section;


 


(ii)         the
Trustee shall not be liable for any error of judgment made in good faith by a Responsible Officer or Responsible Officers of the Trustee,
unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts; and


 


(iii)        the
Trustee shall not be liable with respect to any action taken or omitted to be taken by it in good faith in accordance with the direction
of the Holders pursuant to Section 4.09 relating to the time, method and place of conducting any proceeding for any remedy available
to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture.


 


(d)            None
of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise incur personal financial
liability in the performance of any of its duties or in the exercise of any of its rights or powers, if there shall be reasonable ground
for believing that the repayment of such funds or adequate indemnity against such liability is not reasonably assured to it.


 


(e)            Whether
or not therein expressly so provided, every provision of this Indenture relating to the conduct or affecting the liability of or affording
protection to the Trustee shall be subject to the provisions of this Section 5.01.


 


(f)             The
provisions of this Section 5.01 are in furtherance of and subject to sections 315 and 316 of the Trust Indenture Act of 1939.


 


Section 5.02     Certain
Rights of the Trustee. In furtherance of and subject to the Trust Indenture Act of 1939, and subject to Section 5.01:


 


(a)            the
Trustee may conclusively rely and shall be fully protected in acting or refraining from acting upon any resolution, Officers’ Certificate
or any other certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note,
other evidence of indebtedness, coupon, security or other paper or document believed by it to be genuine and to have been signed or presented
by the proper party or parties;


 


(b)            any
request, direction, order or demand of the Issuer mentioned herein shall be sufficiently evidenced by a Company Order (unless other evidence
in respect thereof be herein specifically prescribed), and any resolution of the Board of Directors of the Issuer may be evidenced to
the Trustee by a Board Resolution;


 


(c)            the
Trustee may consult with counsel and the advice of such counsel or any Opinion of Counsel shall be full and complete authorization and
protection in respect of any action taken, suffered or omitted to be taken by it hereunder in good faith and in reliance thereon;


 


(d)            the
Trustee shall be under no obligation to exercise any of the rights, trusts or powers vested in it by this Indenture at the request, order
or direction of any of the Securityholders pursuant to the provisions of this Indenture, unless such Securityholders shall have offered
to the Trustee security and/or indemnity satisfactory to the Trustee against the costs, expenses and liabilities which might be incurred
by it in compliance with such request, order or direction;


 






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(e)            the
Trustee shall not be liable for any action taken, suffered or omitted by it in good faith and believed by it to be authorized or within
the discretion, rights or powers conferred upon it by this Indenture;


 


(f)             the
Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement, instrument,
opinion, report, notice, request, direction, consent, order, approval, appraisal, bond, debenture, note, other evidence of indebtedness,
coupon, security, or other paper or document unless requested in writing so to do by the Holders of not less than a majority in aggregate
principal amount of the Securities of all series affected then Outstanding; provided that, if the payment within a reasonable time to
the Trustee of the costs, expenses or liabilities likely to be incurred by it in the making of such investigation is, in the opinion
of the Trustee, not reasonably assured to the Trustee by the security afforded to it by the terms of this Indenture, the Trustee may
require indemnity satisfactory to the Trustee against such expenses or liabilities as a condition to proceeding; the reasonable expenses
of every such investigation shall be paid by the Issuer or, if paid by the Trustee or any predecessor trustee, shall be repaid by the
Issuer upon demand;


 


(g)            the
Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents or
attorneys;


 


(h)            the
Trustee shall not be deemed to have notice or be charged with knowledge of any default or Event of Default with respect to the Securities,
unless either (1) solely with respect to a default or Event of Default pursuant to Sections 4.01(a), (b) or (c), and if the
Trustee is also acting as Paying Agent with respect to the Securities, a Responsible Officer shall have actual knowledge of such default
or Event of Default or (2) written notice of such default or Event of Default from the Issuer or any Holder is received by a Responsible
Officer of the Trustee at the Corporate Trust Office of the Trustee and such notice references the Securities and this Indenture;


 


(i)             the
rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be indemnified,
are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other Person
employed to act hereunder; provided, however, only the Trustee, and not any agent, custodian or other Person employed to
act hereunder, shall be held to a prudent person standard upon the occurrence of and during an Event of Default;


 


(j)             the
Trustee may request that the Issuer and the Guarantor deliver a certificate setting forth the names of individuals and/or titles of officers
authorized at such time to take specified actions pursuant to this Indenture, which certificate may be signed by any person authorized
to sign an Officers’ Certificate, including any person specified as so authorized in any such certificate previously delivered
and not superseded; and


 


(k)            the
permissive rights of the Trustee enumerated herein shall not be construed as duties.


 






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Section 5.03     Trustee
Not Responsible for Recitals, Disposition of Securities or Application of Proceeds Thereof. The recitals contained herein and in
the Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Issuer or the Guarantor,
as applicable, and neither the Trustee nor any Authenticating Agent assumes any responsibility for the correctness of the same. The Trustee
makes no representation as to the validity or sufficiency of this Indenture or of the Securities. The Trustee shall not be accountable
for the use or application by the Issuer or the Guarantor of any of the Securities or of the proceeds thereof. The Trustee shall not
be responsible to make any calculation with respect to any matter under this Indenture unless specified in a separate agreement between
the Trustee and the Issuer. The Trustee shall have no duty to monitor or investigate the Issuer’s compliance with or the breach
of, or cause to be performed or observed, any representation, warranty, or covenant, or agreement of any Person, other than the Trustee,
made in this Indenture.


 


No provision of this Indenture
shall be deemed to impose any duty or obligation on the Trustee to perform any act or acts, receive or obtain any interest in property
or exercise any interest in property, or exercise any right, power, duty or obligation conferred or imposed on it in any jurisdiction
in which it shall be illegal, or in which, as a result thereof, the Trustee shall become subject to service of process, taxation or other
consequences that, in the sole determination of the Trustee, are adverse to the Trustee, or in which the Trustee shall be unqualified
or incompetent in accordance with applicable law, to perform any such act or acts, to receive or obtain any such interest in property
or to exercise any such right, power, duty or obligation.


 


Section 5.04     Trustee
and Agents May Hold Securities; Collections, Etc. The Trustee, any Authenticating Agent, any Paying Agent, any Security Registrar
or any other agent of the Issuer or the Guarantor, or the Trustee, in its individual or any other capacity, may become the owner or pledgee
of Securities with the same rights it would have if it were not the Trustee or such agent and may otherwise deal with the Issuer and
the Guarantor and receive, collect, hold and retain collections from the Issuer or the Guarantor with the same rights it would have if
it were not the Trustee or such agent.


 


Section 5.05     Moneys
Held by Trustee. Subject to the provisions of Section 9.04 and Section 10.04, all moneys received by the Trustee or any
paying agent shall, until used or applied as herein provided, be held in trust for the purposes for which they were received, but need
not be segregated from other funds except to the extent required by mandatory provisions of law. Neither the Trustee nor any agent of
the Issuer, the Guarantor or the Trustee shall be under any liability for interest on any moneys received by it hereunder. If and when
the Trustee shall be or become a creditor of the Issuer (or any other obligor on the Securities, including the Guarantor), the Trustee
shall be subject to the provisions of the Trust Indenture Act of 1939 regarding the collection of claims against the Issuer (or any such
other obligor, including the Guarantor).


 


Section 5.06     Compensation
and Indemnification of Trustee and its Prior Claim.


 


Each of the Issuer and the Guarantor covenants
and agrees:


 


(a)            to
pay to the Trustee from time to time, and the Trustee shall be entitled to, compensation as the Issuer and the Trustee shall from time
to time agree in writing for all services rendered by it hereunder (which shall not be limited by any provision of law in regard to the
compensation of a trustee of an express trust);


 






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(b)            except
as otherwise expressly provided herein, to pay or reimburse the Trustee and each predecessor Trustee upon its request for all reasonable
expenses, disbursements and advances incurred or made by or on behalf of the Trustee in accordance with any of the provisions of this
Indenture (including the reasonable compensation and the expenses and disbursements of its counsel and of all agents and other persons
not regularly in its employ) except to the extent any such expense, disbursement or advance may arise from its negligence or willful
misconduct; and


 


(c)            to
indemnify the Trustee and each predecessor Trustee for and their officers, agents, directors and employees for, and to hold them harmless
against, any and all loss, damage, claims, liability or expense, including fees and expenses of counsel, including taxes (other than
taxes based upon, measured by or determined by the income of the Trustee or any recoverable taxes including indirect taxes and VAT taxes),
arising out of or in connection with this Indenture, the Securities, the acceptance or administration of the trust or trusts hereunder,
including the costs and expenses of defending itself against any claim (whether asserted by the Issuer, or any Holder or any other Person)
or liability in connection with the exercise or performance of any of its powers or duties hereunder, or in connection with enforcing
the provisions of this Section, except to the extent that such loss, damage, claim, liability or expense is due to the Trustee’s
own negligence or willful misconduct.


 


As security for the performance
of the obligations of the Issuer and the Guarantor under this Section, the Trustee shall have a lien prior to the Securities upon all
property and funds held or collected by the Trustee as such, except funds held in trust for the payment of principal of (and premium,
if any) or interest on particular Securities.


 


When the Trustee incurs any
expenses or renders any services after the occurrence of an Event of Default specified in Section 4.01(e) or 4.01(f), such
expenses (including the reasonable charges and expenses of its counsel) and the compensation for such services are intended to constitute
expenses of administration under the United States Bankruptcy Code (Title 11 of the United States Code) or any applicable federal or
state bankruptcy, insolvency or similar law for the relief of debtors.


 


“Trustee” for
purposes of this Section shall include any predecessor Trustee; provided, however, that the negligence, willful misconduct or bad
faith of any Trustee hereunder shall not affect the rights of any other Trustee hereunder.


 


The provisions of this Section shall
survive the resignation or removal of the Trustee, the satisfaction and discharge of this Indenture and the Securities and the termination
for any reason of this Indenture.


 


Section 5.07     Right
of Trustee to Rely on Officers’ Certificate, etc. Subject to Section 5.01, whenever in the administration of the
trusts of this Indenture the Trustee shall deem it necessary or desirable that a matter be proved or established prior to taking or suffering
or omitting any action hereunder, such matter (unless other evidence in respect thereof be herein specifically prescribed) may, in the
absence of negligence, willful misconduct or bad faith on the part of
the Trustee, be deemed to be conclusively proved and established by an Officers’ Certificate and/or an Opinion of Counsel delivered
to the Trustee, and such certificate, in the absence of negligence, willful
misconduct or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action taken, suffered or omitted
by it under the provisions of this Indenture upon the faith thereof.


 






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Section 5.08     Persons
Eligible for Appointment as Trustee. The Trustee for each series of Securities hereunder shall at all times be a Person organized
and doing business under the laws of the United States of America or of any State thereof or the District of Columbia having a combined
capital and surplus of at least $50,000,000, and which is eligible in accordance with the provisions of section 310(a) of the Trust
Indenture Act of 1939. If such Person publishes reports of condition at least annually, pursuant to law or to the requirements of a Federal,
State or District of Columbia supervising or examining authority, then for the purposes of this Section, the combined capital and surplus
of such Person shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so published.
In case at any time the Trustee shall cease to be eligible in accordance with the provisions of this Section, the Trustee shall resign
immediately in the manner and with the effect specified in Section 5.09. The Trustee shall comply with Section 310(b) of
the Trust Indenture Act of 1939; provided, however, that there shall be excluded from the operation of section 310(b)(1) of the
Trust Indenture Act of 1939 any indenture or indentures under which other securities or certificates of interest or participation in
other securities of the Issuer are outstanding if the requirements for such exclusion set forth in section 310(b)(1) of the Trust
Indenture Act of 1939 are met, including the Indenture, dated as of April 1, 2004 between AstraZeneca PLC and the Trustee (as successor
trustee to JPMorgan Chase Bank), and the Indenture, dated as of                 2021,
between AstraZeneca PLC and the Trustee.


 


Section 5.09     Resignation
and Removal; Appointment of Successor Trustee.


 


(a)            The
Trustee, or any trustee or trustees hereafter appointed, may at any time resign with respect to one or more or all series of Securities
by giving written notice of resignation to the Issuer and the Guarantor and by giving written notice thereof to Holders of the applicable
series of Securities at their last addresses as they shall appear on the Security register. Upon receiving such notice of resignation,
the Issuer shall promptly appoint a successor trustee or trustees with respect to the applicable series by written instrument in duplicate,
executed by authority of the Board of Directors of the Issuer, one copy of which instrument shall be delivered to the resigning Trustee
and one copy to the successor trustee or trustees. If no successor trustee shall have been so appointed with respect to any series and
have accepted appointment within 30 days after the mailing of such notice of resignation, the resigning trustee may petition any court
of competent jurisdiction for the appointment of a successor trustee, or any Securityholder who has been a bona fide Holder of a Security
or Securities of the applicable series for at least six months may, subject to the provisions of Section 4.12, on behalf of himself
and all others similarly situated, petition any such court for the appointment of a successor trustee. Such court may thereupon, after
such notice, if any, as it may deem proper and prescribe, appoint a successor trustee.


 


(b)            In
case at any time any of the following shall occur:


 


(i)          the
Trustee shall fail to comply with the provisions of section 310(b) of the Trust Indenture Act of 1939 with respect to any series
of Securities after written request therefor by the Issuer, the Guarantor or by any Securityholder who has been a bona fide Holder of
a Security or Securities of such series for at least six months;


 






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(ii)         the
Trustee shall cease to be eligible in accordance with the provisions of section 310(a) of the Trust Indenture Act of 1939 and shall
fail to resign after written request therefor by the Issuer or by any Securityholder;


 


(iii)        the
Trustee shall become incapable of acting with respect to any series of Securities, or shall be adjudged a bankrupt or insolvent, or a
receiver or liquidator of the Trustee or of its property shall be appointed, or any public officer shall take charge or control of the
Trustee or of its property or affairs for the purpose of rehabilitation, conservation or liquidation; or


 


(iv)        the
Trustee shall fail to perform its obligations to the Issuer and the Guarantor under this Indenture in any material respect,


 


then, in any such case, the Issuer may remove
the Trustee with respect to any or all series of Securities and appoint a successor trustee for such series by written instrument, in
duplicate, executed by order of the Board of Directors of the Issuer, one copy of which instrument shall be delivered to the Trustee
so removed and one copy to the successor trustee, or, other than in the case of paragraph (b)(iv) above and subject to section 315(e) of
the Trust Indenture Act of 1939, any Securityholder who has been a bona fide Holder of a Security or Securities of the applicable series
for at least six months may on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for
the removal of the Trustee and the appointment of a successor trustee with respect to such series. Such court may thereupon, after such
notice, if any, as it may deem proper and prescribe, remove the Trustee and appoint a successor trustee.


 


(c)            The
Holders of a majority in aggregate principal amount of the Securities of each series at the time Outstanding may at any time remove the
Trustee with respect to Securities of such series and appoint a successor trustee with respect to the Securities of such series by delivering
to the Trustee so removed, to the successor trustee so appointed and to the Issuer and the Guarantor the evidence provided for in Section 6.01
of the action in that regard taken by the Securityholders.


 


(d)            Any
resignation or removal of the Trustee with respect to any series and any appointment of a successor trustee with respect to such series
pursuant to any of the provisions of this Section 5.09(b) shall become effective upon acceptance of appointment by the successor
trustee as provided in Section 5.10.


 


(e)            At
any time there shall be only one Trustee with respect to the Securities.


 


Section 5.10     Acceptance
of Appointment by Successor Trustee. Any successor trustee appointed as provided in Section 5.09 shall execute and deliver to
the Issuer, the Guarantor and to the predecessor Trustee an instrument accepting such appointment hereunder, and thereupon the resignation
or removal of the predecessor Trustee with respect to all or any applicable series shall become effective and such successor trustee,
without any further act, deed or conveyance, shall become vested with all rights, powers, duties and obligations with respect to such
series of its predecessor hereunder, with like effect as if originally named as trustee for such series hereunder; but, nevertheless,
on the written request of the Issuer, the Guarantor or of the successor trustee, upon payment of any amounts due to it pursuant to Section 5.06,
the trustee ceasing to act shall, subject to Section 9.04 pay over to the successor trustee all moneys at the time held by it hereunder
and shall execute and deliver an instrument transferring to such successor trustee all such rights, powers, duties and obligations. Upon
request of any such successor trustee, the Issuer and the Guarantor shall execute any and all instruments in writing for more fully and
certainly vesting in and confirming to such successor trustee all such rights and powers. Any trustee ceasing to act shall, nevertheless,
retain a prior lien upon all property or funds held or collected by such trustee to secure any amounts then due it pursuant to the provisions
of Section 5.06.


 






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If a successor trustee is
appointed with respect to the Securities of one or more (but not all) series, the Issuer, the Guarantor, the predecessor trustee and
each successor trustee with respect to the Securities of any applicable series shall execute and deliver an indenture supplemental hereto
which shall contain such provisions as shall be deemed necessary or desirable to confirm that all the rights, powers, trusts and duties
of the predecessor trustee with respect to the Securities of any series as to which the predecessor trustee is not retiring shall continue
to be vested in the predecessor trustee, and shall add to or change any of the provisions of this Indenture as shall be necessary to
provide for or facilitate the administration of the trusts hereunder by more than one trustee, it being understood that nothing herein
or in such supplemental indenture shall constitute such trustees co-trustees of the same trust and that each such trustee shall be trustee
of a trust or trusts under separate indentures.


 


No successor trustee with
respect to any series of Securities shall accept appointment as provided in this Section 5.10 unless at the time of such acceptance
such successor trustee shall be eligible under the provisions of Section 5.08.


 


Upon acceptance of appointment
by any successor trustee as provided in this Section 5.10, the Issuer shall mail notice thereof by first-class mail to the Holders
of Securities of any series for which such successor trustee is acting as trustee at their last addresses as they shall appear in the
Security register. If the acceptance of appointment is substantially contemporaneous with the resignation, then the notice called for
by the preceding sentence may be combined with the notice called for by Section 5.09. If the Issuer fails to mail such notice within
ten days after acceptance of appointment by the successor trustee, the successor trustee shall cause such notice to be mailed at the
expense of the Issuer.


 


Section 5.11     Merger,
Conversion, Consolidation or Succession to Business of Trustee. Any Person into which the Trustee may be merged or converted or with
which it may be consolidated, or any Person resulting from any merger, conversion or consolidation to which the Trustee shall be a party,
or any Person succeeding to the corporate trust business of the Trustee, shall be the successor of the Trustee hereunder; provided that
such Person shall be eligible under the provisions of Section 5.08 without the execution or filing of any paper or any further act
on the part of any of the parties hereto, anything herein to the contrary notwithstanding.


 


In case at the time such
successor to the Trustee shall succeed to the trusts created by this Indenture any of the Securities of any series shall have been authenticated
but not delivered, any such successor to the Trustee may adopt the certificate of authentication of any predecessor Trustee and deliver
such Securities so authenticated; and, in case at that time any of the Securities of any series shall not have been authenticated, any
successor to the Trustee may authenticate such Securities either in the name of any predecessor hereunder or in the name of the successor
Trustee; and in all such cases such certificate shall have the full force which it is anywhere in the Securities of such series or in
this Indenture provided that the certificate of the Trustee shall have; provided, that the right to adopt the certificate of authentication
of any predecessor Trustee or to authenticate Securities of any series in the name of any predecessor Trustee shall apply only to its
successor or successors by merger, conversion or consolidation.


 






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Section 5.12     FATCA.


 


Notwithstanding any other
provision of this Indenture, the Trustee shall be entitled to make a deduction or withholding from any payment which it makes under this
Indenture for or on account of any present or future taxes, duties or charges if and to the extent so required by any applicable law
and any current or future regulations or agreements thereunder or official interpretations thereof or any law implementing an intergovernmental
approach thereto or by virtue of the relevant holder failing to satisfy any certification or other requirements in respect of the Securities,
in which event the Trustee shall make such payment after such withholding or deduction has been made and shall account to the relevant
authorities for the amount so withheld or deducted and shall have no obligation to gross up any payment hereunder or pay any additional
amount as a result of such withholding tax.


 


Article 6

CONCERNING THE SECURITYHOLDERS


 


Section 6.01     Evidence
of Action Taken by Securityholders. Any request, demand, authorization, direction, notice, consent, waiver or other action provided
by this Indenture to be given or taken by a specified percentage in principal amount of the Securityholders of any or all series of the
Securities may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such specified percentage
of Securityholders in person or by agent duly appointed in writing; and, except as herein otherwise expressly provided, such action shall
become effective when such instrument or instruments are delivered to the Trustee. Proof of execution of any instrument or of a writing
appointing any such agent shall be sufficient for any purpose of this Indenture and (subject to Section 5.01) conclusive in favor
of the Trustee, the Issuer and the Guarantor, if made in the manner provided in this Article.


 


Section 6.02     Proof
of Execution of Instruments and of Holding of Securities; Record Date. Subject to Section 5.01, the execution of any instrument
by a Securityholder or his agent or proxy may be proved in accordance with such reasonable rules and regulations as may be prescribed
by the Trustee or in such manner as shall be satisfactory to the Trustee. The holding of Securities shall be proved by the Security register
or by a certificate of the registrar thereof. The Issuer may, but shall not be obligated to, set a record date for purposes of determining
the identity of Securityholders of any series entitled to vote or consent to any action referred to in Section 6.01, which record
date may be set at any time or from time to time by notice to the Trustee. If a record date is fixed, then notwithstanding Section 6.01
and Section 6.05, those persons who were Securityholders at such record date (or their duly designated proxies), and only those
persons, shall be entitled to give such consent or to revoke any consent previously given or to take any such action, whether or not
such persons continue to be Securityholders after such record date. No such consent shall be valid or effective for more than 90 days
after such record date.


 






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Section 6.03     Holders
to Be Treated as Owners. The Issuer, the Guarantor, the Trustee and any agent of the Issuer, the Guarantor or the Trustee may deem
and treat the person in whose name any Security shall be registered upon the Security register for such series as the absolute owner
of such Security (whether or not such Security shall be overdue and notwithstanding any notation of ownership or other writing thereon)
for the purpose of receiving payment of or on account of the principal of and, subject to the provisions of this Indenture, interest
on such Security and for all other purposes; and none of the Issuer, the Guarantor or the Trustee or any agent of the Issuer, the Guarantor
or the Trustee shall be affected by any notice to the contrary. All such payments so made to any such person, or upon his order, shall
be valid, and, to the extent of the sum or sums so paid, effectual to satisfy and discharge the liability for moneys payable upon any
such Security.


 


Section 6.04     Securities
Owned by Issuer Deemed Not Outstanding. In determining whether the Holders of the requisite aggregate principal amount of Outstanding
Securities of any or all series have concurred in any request, demand, authorization, direction, notice, consent, waiver or other action
by Securityholders under this Indenture, Securities which are owned by the Issuer, the Guarantor or any other obligor on the Securities
with respect to which such determination is being made or by any person directly or indirectly controlling or controlled by or under
direct or indirect common control with the Issuer, the Guarantor or any other obligor on the Securities with respect to which such determination
is being made shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except that for the purpose
of determining whether the Trustee shall be protected in relying on any such action only Securities which a Responsible Officer the Trustee
knows are so owned shall be so disregarded. Securities so owned which have been pledged in good faith may be regarded as Outstanding
if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to act with respect to such Securities and
that the pledgee is not the Issuer, the Guarantor or any other obligor upon the Securities or any person directly or indirectly controlling
or controlled by or under direct or indirect common control with the Issuer, the Guarantor or any other obligor on the Securities. In
case of a dispute as to such right, the advice of counsel shall be full protection in respect of any decision made by the Trustee in
accordance with such advice. Upon request of the Trustee, the Issuer shall furnish to the Trustee promptly Officers’ Certificates
listing and identifying all Securities, if any, known by the Issuer and the Guarantor to be owned or held by or for the account of any
of the above-described persons; and, subject to Section 5.01, the Trustee shall be entitled to accept such Officers’ Certificates
as conclusive evidence of the facts therein set forth and of the fact that all Securities not listed therein are Outstanding for the
purpose of any such determination.


 


Section 6.05     Right
of Revocation of Action Taken. At any time prior to (but not after) the evidencing to the Trustee, as provided in Section 6.01,
of the taking of any action by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as
the case may be, specified in this Indenture in connection with such action, any Holder of a Security the serial number or other distinguishing
symbol of which is shown by the evidence to be included among the serial numbers or other distinguishing symbols of the Securities the
Holders of which have consented to such action may, by filing written notice at the Corporate Trust Office and upon proof of holding
as provided in this Article, revoke such action so far as concerns such Security. Except as aforesaid any such action taken by the Holder
of any Security shall be conclusive and binding upon such Holder and upon all future Holders and owners of such Security and of any Securities
issued in exchange or substitution therefor or on registration of transfer thereof, irrespective of whether or not any notation in regard
thereto is made upon any such Security. Any action taken by the Holders of the percentage in aggregate principal amount of the Securities
of any or all series, as the case may be, specified in this Indenture in connection with such action shall be conclusively binding upon
the Issuer, the Guarantor, the Trustee and the Holders of all the Securities affected by such action.


 






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Article 7

SUPPLEMENTAL INDENTURES


 


Section 7.01     Supplemental
Indentures Without Consent of Securityholders. The Issuer and the Guarantor, when authorized by resolutions of their respective Board
of Directors (or any committee authorized by the Board of Directors or officer authorized by such Board of Directors or committee), and
the Trustee may from time to time and at any time enter into an indenture or indentures supplemental hereto (which shall conform to the
provisions of the Trust Indenture Act of 1939 as in force on the date of the execution thereof) for one or more of the following purposes:


 


(a)            to
convey, transfer, assign, mortgage or pledge to the Trustee as security for the Securities of one or more series any property or assets;


 


(b)            to
evidence the succession of another Person to the Issuer or the Guarantor, or successive successions, and the assumption by the successor
Person of the covenants, agreements and obligations of the Issuer and/or the Guarantor, as the case may be, pursuant to Article 8;


 


(c)            to
evidence and provide for the acceptance of appointment hereunder by a successor trustee with respect to the Securities of one or more
series and to add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration
of the trusts hereunder by more than one trustee, pursuant to the requirements of Section 5.10;


 


(d)            to
add to the covenants of the Issuer or the Guarantor such further covenants, restrictions, conditions or provisions (and if such further
covenants, restrictions, conditions or provisions are to be for the benefit of less than all series of Securities, stating that such
covenants, restrictions, conditions or provisions are expressly being included solely for the benefit of such series) as the Board of
Directors of the Issuer or the Guarantor and the Trustee shall consider to be for the protection of the Holders of Securities, and to
make the occurrence, or the occurrence and continuance, of a default in any such additional covenants, restrictions, conditions or provisions
an Event of Default permitting the enforcement of all or any of the several remedies provided in this Indenture as herein set forth;
provided, that in respect of any such additional covenant, restriction, condition or provision such supplemental indenture may provide
for a particular period of grace after default (which period may be shorter or longer than that allowed in the case of other defaults)
or may provide for an immediate enforcement upon such an Event of Default or may limit the remedies available to the Trustee upon such
an Event of Default or may limit the right of the Holders of a majority in aggregate principal amount of the Securities of such series
to waive such an Event of Default;


 


(e)            to
cure any ambiguity or to correct or supplement any provision contained herein or in any supplemental indenture which may be defective
or inconsistent with any other provision contained herein or in any supplemental indenture;


 


(f)             to
make such other provisions in regard to matters or questions arising under this Indenture or under any supplemental indenture as the
Board of Directors of the Issuer or the Guarantor may deem necessary or desirable and which shall not adversely affect the interests
of the Holders of the Securities in any material respect;


 






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(g)            to
establish the form or terms of Securities of any series as permitted by Section 2.01 and Section 2.08;


 


(h)            to
add or change any of the provisions of this Indenture to such extent as shall be necessary to permit or facilitate the issuance of Securities
in bearer form, registrable or not registrable as to principal, and with or without interest coupons, or to permit or facilitate the
issuance of Securities in uncertificated form; provided that any such action shall not adversely affect the interests of the Holders
of Securities of any series in any material respect; and


 


(i)             to
add to, change or eliminate any of the provisions of this Indenture in respect of one or more series of Securities; provided that any
such addition, change or elimination (i) shall neither (A) apply to any Security of any series created prior to the execution
of such supplemental indenture and entitled to the benefit of such provision nor (B) modify the rights of the Holder of any such
Security with respect to such provision or (ii) shall become effective only when there is no Security Outstanding.


 


The Trustee is hereby authorized
to join with the Issuer and the Guarantor in the execution of any such supplemental indenture, to make any further appropriate agreements
and stipulations which may be therein contained and to accept the conveyance, transfer, assignment, mortgage or pledge of any property
thereunder, but the Trustee shall not be obligated to enter into any such supplemental indenture which affects the Trustee’s own
rights, duties or immunities under this Indenture or otherwise.


 


Any supplemental indenture
authorized by the provisions of this Section may be executed without the consent of the Holders of any of the Securities at the
time outstanding, notwithstanding any of the provisions of Section 7.02.


 


Section 7.02     Supplemental
Indentures with Consent of Securityholders. With the consent (evidenced as provided in Article 6) of the Holders of not less
than a majority in aggregate principal amount of the Securities at the time Outstanding of all series affected by such supplemental indenture
(each affected series voting as a separate class), the Issuer and the Guarantor, each when authorized by resolutions of its respective
Board of Directors (or any committee authorized by the Board of Directors or officer authorized by such Board of Directors or committee)
and the Trustee may, from time to time and at any time, enter into an indenture or indentures supplemental hereto (which shall conform
to the provisions of the Trust Indenture of 1939 as in force at the date of execution thereof) for the purpose of adding any provisions
to or changing in any manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying
in any manner the rights of the Holders of the Securities of each such series; provided, that no such supplemental indenture shall (a) extend
the final maturity of any Security, or reduce the principal amount thereof, or reduce the rate or extend the time of payment of interest,
if any, thereon, or reduce any amount payable on redemption thereof or reduce the amount of the principal of an Original Issue Discount
Security that would be due and payable upon an acceleration of the maturity thereof pursuant to Section 4.01 or the amount thereof
provable in bankruptcy pursuant to Section 4.02, or impair or affect the right of any Securityholder to institute suit for the payment
thereof or, if the Securities provide therefor, any right of repayment at the option of the Securityholder without the consent of the
Holder of each Security so affected, (b) reduce the aforesaid percentage of Securities of any series, the consent of the Holders
of which is required for any such supplemental indenture, without the consent of the Holders of each Security so affected, (c) change
in any manner adverse to the Holders of the Securities the terms and conditions of the obligations of the Guarantor in respect of the
Guaranty, without the consent of the Holder of each Security so affected or (d) change in any manner adverse to the Holders of the
Securities the terms and conditions of the obligations of the Issuer in respect of the due and punctual payment of the principal thereof
and interest thereon or any sinking fund payments provided in respect thereof, in each case without the consent of the Holder of each
Security so affected.


 






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A supplemental indenture
which changes or eliminates any covenant or other provision of this Indenture which has expressly been included solely for the benefit
of one or more particular series of Securities, or which modifies the rights of the Holders of Securities of such series with respect
to such covenant or other provision, shall be deemed not to affect the rights under this Indenture of the Holders of Securities of any
other series.


 


Upon the request of the Issuer
accompanied by a copy of a resolution of the Board of Directors certified by the secretary or an assistant secretary of the Issuer authorizing
the execution of any such supplemental indenture, and upon the filing with the Trustee of evidence of the consent of Securityholders
as aforesaid and other documents, if any, required by Section 6.01, the Trustee shall join with the Issuer and the Guarantor in
the execution of such supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties or immunities
under this Indenture or otherwise, in which case the Trustee may in its discretion, but shall not be obligated to, enter into such supplemental
indenture.


 


It shall not be necessary
for the consent of the Securityholders under this Section to approve the particular form of any proposed supplemental indenture,
but it shall be sufficient if such consent shall approve the substance thereof.


 


Promptly after the execution
by the Issuer, the Guarantor and the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Issuer shall
mail a notice thereof by first class mail or as otherwise provided by the customary practices and procedures of the Depositary, including
through electronic delivery, to the Holders of Securities of each series affected thereby at their addresses as they shall appear on
the Security register setting forth in general terms the substance of such supplemental indenture. Any failure of the Issuer to mail
such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture.


 


Section 7.03     Effect
of Supplemental Indenture. Upon the execution of any supplemental indenture pursuant to the provisions hereof, this Indenture shall
be and be deemed to be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties
and immunities under this Indenture of the Trustee, the Issuer, the Guarantor and the Holders of Securities of each series affected thereby
shall thereafter be determined, exercised and enforced hereunder subject in all respects to such modifications and amendments, and all
the terms and conditions of any such supplemental indenture shall be and be deemed to be part of the terms and conditions of this Indenture
for any and all purposes.


 






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Section 7.04       Documents
to be Given to Trustee. The Trustee, subject to the provisions of Section 5.01, shall receive Officers’ Certificates and
Opinions of Counsel, as appropriate, as conclusive evidence that any supplemental indenture executed pursuant to this Article 7
is authorized and permitted by this Indenture and complies with the applicable provisions of this Indenture and an Opinion of Counsel
to the effect that such supplemental indenture is enforceable against the Issuer in accordance with its terms, subject to then customary
exceptions. The Trustee may, but will not be obligated to, enter into any such supplemental indenture which affects the Trustee’s
own rights, duties, or immunities under this Indenture or otherwise.


 


Section 7.05       Notation
on Securities in Respect of Supplemental Indentures. Securities of any series authenticated and delivered after the execution of
any supplemental indenture pursuant to the provisions of this Article may bear a notation in form approved by the Trustee for such
series as to any matter provided for by such supplemental indenture. If the Issuer, the Guarantor or the Trustee shall so determine,
new Securities of any series so modified as to conform, in the opinion of the Trustee and the Issuer and the Guarantor, to any modification
of this Indenture contained in any such supplemental indenture may be prepared and executed by the Issuer and the Guarantor, authenticated
by the Trustee and delivered in exchange for the Securities of such series then Outstanding.


 


Section 7.06       Conformity
with Trust Indenture Act of 1939. Every supplemental indenture executed pursuant to this Article shall conform to the requirements
of the Trust Indenture Act of 1939.


 






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Article 8

CONSOLIDATION OR MERGER


 


Section 8.01       Issuer
May Consolidate, etc., on Certain Terms. (a) Nothing contained in this Indenture or in any of the Securities shall
prevent any amalgamation, reconstruction, consolidation or merger of the Issuer with or into any other Person (whether or not affiliated
with the Issuer), or successive amalgamations, reconstructions, consolidations or mergers in which the Issuer or its successor or successors
shall be a party or parties; provided, however, that the Person formed by such amalgamation, restructuring or consolidation, or into which
the Issuer shall merge, is organized and validly existing under the laws of any state of the United States, the United Kingdom or another
jurisdiction that is a member country of the Organization for Economic Cooperation and Development (or any successor thereto) and provided
further that the Issuer hereby covenants and agrees that, upon any such amalgamation, reconstruction, consolidation or merger, (i) unless
the surviving Person is the Issuer, the due and punctual performance and observance of all of the covenants and conditions of this Indenture
to be performed by the Issuer (including, if applicable, submission to jurisdiction), shall be expressly assumed by supplemental indenture
satisfactory in form to the Trustee, executed and delivered to the Trustee, by the Person formed by such amalgamation, reconstruction
or consolidation, or into which the Issuer shall have been merged, (ii) unless the surviving Person is the Issuer, the Guarantor,
unless it is the other party to the transactions described above, shall have by supplemental indenture confirmed that its Guaranty shall
apply to the successor’s obligations under the Securities and this Indenture, and (iii) if the Person formed by such amalgamation,
reconstruction or consolidation, or into which the Issuer shall have been merged, is resident for tax purposes elsewhere than the United
States (and, if such Person is treated as a “domestic corporation” for U.S. federal income tax purposes, such successor Person
shall be treated as a “resident” of the United States for U.S. federal income tax purposes), such Person shall, in such supplemental
indenture, agree that if any deduction or withholding for any present or future taxes, levies, imposts or other governmental charges whatsoever
imposed, assessed, levied or collected by or for the account of the jurisdiction in which it is resident for tax purposes or any political
subdivision or taxing authority thereof or therein shall at any time be required by such jurisdiction (or any such political subdivision
or taxing authority) in respect of any amounts to be paid by such successor Person under the Securities, such Person will (subject to
compliance by the Holders of such Securities with any administrative requirements) pay such additional amounts as may be necessary in
order that the net amounts paid to the Holders of the Securities or the Trustee under this Indenture or, as the case may be, pursuant
to the Securities, after such deduction or withholding, shall be not less than the amounts specified in the Securities, to which such
Holders or the Trustee are entitled had no such withholding or deduction been required; provided, however, that the successor Person shall
not be required to make any payment of additional amounts for or on account of (i) any present or future tax, levy, impost or other
governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that the Holder of the relevant
Security (or a fiduciary, settlor, beneficiary, member or shareholder of, or possessor of a power over, such Holder, if such Holder is
an estate, trust, partnership or corporation) is or has been a domiciliary, national or resident of, or is or has been engaged in a trade
or business in, or maintains or has maintained a permanent establishment in, or is or has been physically present in, such jurisdiction
or any political subdivision or taxing authority thereof or therein or otherwise has or has had some connection with such jurisdiction
or any political subdivision or taxing authority thereof or therein other than the holding or ownership of the Security, or the collection
of principal, premium or interest, if any, on, or the enforcement of, the Security, (ii) any present or future tax, levy, impost
or other governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that, where presentation
is required, the relevant Security was presented more than thirty days after the date on which such payment became due or was provided
for, whichever is later, (iii) any estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other
governmental charge, (iv) any present or future tax, levy, impost or other governmental charge which is payable otherwise than by
deduction or withholding from payments on or in respect of the relevant Security, (v) any present or future tax, levy, impost or
other governmental charge which would not have been so imposed, assessed, levied or collected but for the failure of the Holder or the
beneficial owner of the relevant Security to comply with any certification, identification or other reporting requirements concerning
the Holder’s or beneficial owner’s nationality, residence, identity or connection with such jurisdiction or any political
subdivision or taxing authority thereof or therein, if compliance is required by treaty or by statute, regulation or administrative practice
of such jurisdiction or of any such political subdivision or taxing authority thereof or therein as a condition to relief or exemption
from such tax, levy, impost or other governmental charge, (vi) any present or future tax, levy, impost or other governmental charge
which the Holder would have been able to avoid by authorizing the paying agent to report information in accordance with the procedure
laid down by the relevant tax authority or by producing, in the form requested by the relevant tax authority, a declaration, claim, certificate,
document or other evidence establishing exemption therefrom, (vii) any present or future tax, levy, impost or other governmental
charge which is required by FATCA, any current or future U.S. Treasury regulations or rulings promulgated thereunder, any IGA, any law,
regulation or other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal
Revenue Service under or with respect to FATCA, (viii) any present or future tax, levy, impost or other governmental charge which
is imposed or withheld because the Holder of the Security is (1) considered a 10% shareholder (within the meaning of Sections 871(h)(3) or
881(c)(3) of the Code) of the issuer of the Security or (2) a controlled foreign corporation related (within the meaning of
Section 864(d)(4) of the Code) to the issuer of the Security, (ix) any present or future tax, levy, impost or other governmental
charge which is imposed because the Holder (1) is a bank purchasing the Security in the ordinary course of its lending business or
(2) is a bank that is neither (A) buying the Security for investment purposes only nor (B) buying the Security for resale
to a third party that either is not a bank or will hold the Security for investment purposes only, (x) any present or future tax,
levy, impost or other governmental charge which is imposed, assessed, levied or collected in respect of a payment under or with respect
to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the sole beneficial owner
of such payment or Security to the extent that the beneficiary or settlor with respect to the fiduciary, member of that partnership or
beneficial owner would not have been entitled to the additional amounts or would not have been subject to such tax, levy, impost or charge,
had that beneficiary, settlor, member or beneficial owner been the actual Holder of such Security, or (xi) any combination of clauses
(i) through (x) above, and nor shall additional amounts be paid in the event that the obligation
to pay additional amounts is the result of the issuance of definitive Registered Securities to a Holder of a Predecessor Security at such
Holder’s request upon the occurrence of an Event of Default and at the time payment is made definitive Registered Securities have
not been issued in exchange for the entire principal amount of the Predecessor Securities.




 






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For the avoidance of doubt,
nothing contained in this Indenture or in any of the Securities shall prevent any sale, transfer or conveyance of the property of the
Issuer as an entirety or substantially as an entirety (not involving an amalgamation, reconstruction, consolidation or merger of the
Issuer) without compliance with this Section 8.01, including, but not limited to, any such sale, transfer or conveyance that represents
or is done in furtherance of the intended use of proceeds for the respective series of the Securities.


 


Section 8.02       Securities
to be Secured in Certain Events. If, upon any such amalgamation, reconstruction, consolidation or merger of the Issuer with or into
any other Person, any Principal Property of the Guarantor or of any of its Restricted Subsidiaries or any shares of stock or indebtedness
of any such Restricted Subsidiary would thereupon become subject to any mortgage, pledge or lien which would be prohibited by Section 3.09,
the Issuer, prior to such amalgamation, reconstruction, consolidation, merger, will secure the Securities, equally and ratably with any
other obligations of the Issuer then entitled thereto, by a direct lien on all such property equally and ratably with all such mortgages,
pledges or liens.


 


Section 8.03       Successor
Person to be Substituted for Issuer. In case of any such amalgamation, reconstruction, consolidation or merger and following such
an assumption by the successor Person, such successor Person shall succeed to and be substituted for the Issuer, with the same effect
as if it had been named herein, and the Issuer shall be relieved of all obligations and covenants under this Indenture and the Securities.
Such successor Person thereupon may cause to be signed, and may issue either in its own name or in the name of the Issuer, all of the
Securities issuable hereunder which theretofore shall not have been signed by the Issuer and delivered to the Trustee. All the Securities
so issued shall in all respects have the same legal rank and benefit under this Indenture as the Securities theretofore and thereafter
issued in accordance with the terms of this Indenture as though all of such Securities had been issued at the date of the execution hereof,
and shall have the benefit of the Guaranty as at the date of execution hereof. In case of any such amalgamation, reconstruction, consolidation
or merger, such changes in phraseology and form (but not in substance) may be made in the Securities thereafter to be issued as may be
appropriate.


 






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Section 8.04       Opinion
of Counsel to Trustee. The Trustee, subject to the provisions of Section 5.01, shall receive an Opinion of Counsel, prepared
in accordance with Section 10.05, as conclusive evidence that any such amalgamation, reconstruction, consolidation or merger, and
any such assumption, and any such liquidation or dissolution, complies with the applicable provisions of this Indenture.


 


Article 9

SATISFACTION AND DISCHARGE OF INDENTURE; UNCLAIMED MONEYS


 


Section 9.01       Satisfaction
and Discharge of Indenture. If at any time (a) the Issuer shall have paid or caused to be paid the principal of and interest,
if any, on all the Securities of any series Outstanding hereunder as and when the same shall have become due and payable, or (b) the
Issuer shall have delivered to the Trustee for cancellation all Outstanding Securities of any series theretofore authenticated or (c) (i) all
the Securities of such series not theretofore delivered to the Trustee for cancellation shall have become due and payable, or are by
their terms to become due and payable within one year or are to be called for redemption within one year under arrangements satisfactory
to the Trustee for the giving of notice of redemption, and (ii) the Issuer shall have irrevocably deposited or caused to be deposited
with the Trustee as trust funds the entire amount in cash (other than moneys repaid by the Trustee or any paying agent to the Issuer
in accordance with Section 9.05) or Government Obligations, maturing as to principal and interest in such amounts and at such times
as will insure the availability of cash, sufficient, without reinvestment, and, in the case of a deposit of Government Obligations, in
the opinion of a nationally recognized investment bank, appraisal firm or firm of independent public accountants expressed in a written
certification thereof delivered to the Trustee, to pay at maturity or upon redemption all Outstanding Securities of such series not theretofore
delivered to the Trustee for cancellation, including principal and interest, if any, due or to become due on or prior to such date of
maturity as the case may be, and if, in any such case, the Issuer shall also pay or cause to be paid all other sums payable hereunder
by the Issuer with respect to Securities of such series, then this Indenture shall cease to be of further effect with respect to Securities
of such series and the related Guaranty of the Guarantor (except as to (i) rights of registration of transfer and exchange of Securities
of such series, and the Issuer’s right of optional redemption, if any, (ii) substitution of mutilated, defaced, destroyed,
lost or stolen Securities, (iii) rights of Holders to receive payments of principal thereof and interest, if any, thereon, upon
the original stated due dates therefor (but not upon acceleration), and remaining rights of the Holders to receive mandatory sinking
fund payments, if any, from funds deposited with the Trustee, (iv) the rights, obligations and immunities of the Trustee hereunder
and (v) the rights of the Securityholders of such series as beneficiaries hereof with respect to the property so deposited with
the Trustee payable to all or any of them), and the Trustee, on demand of the Issuer accompanied by an Officers’ Certificate and
an Opinion of Counsel and at the cost and expense of the Issuer, shall execute proper instruments acknowledging such satisfaction of
and discharging this Indenture with respect to such series; provided, that the rights of Holders of the Securities to receive amounts
in respect of principal of and interest, if any, on the Securities held by them shall not be delayed longer than required by then-applicable
mandatory rules or policies of any securities exchange upon which the Securities are listed. The Issuer agrees to reimburse the
Trustee for any costs or expenses thereafter reasonably and properly incurred and to compensate the Trustee for any services thereafter
reasonably and properly rendered by the Trustee in connection with this Indenture or the Securities of such series. At such time as the
Issuer shall have effected such satisfaction and discharge of this Indenture with respect to any series of Securities, the Guarantor
shall be automatically and unconditionally released and discharged from all of its obligations under its Guaranty of the Securities of
such series and all of its other obligations under this Indenture in respect of the Securities of such series, without any action by
the Issuer, the Guarantor or the Trustee and without the consent of the Holders of any Securities.


 






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Section 9.02       Application
by Trustee of Funds Deposited for Payment of Securities. Subject to Section 9.04 and Section 9.05, all moneys deposited
with the Trustee pursuant to Section 9.01 shall be held in trust and applied by it to the payment, either directly or through any
paying agent (including the Issuer acting as paying agent), to the Holders of the particular Securities of such series for the payment
or redemption of which such moneys have been deposited with the Trustee, of all sums due and to become due thereon for principal and
interest, if any; but such money need not be segregated from other funds except to the extent required by law.


 


Section 9.03       Defeasance
upon Deposit of Moneys or Government Obligations. At the Issuer’s option, either (a) the Issuer shall be deemed to have
been Discharged (as defined below) from its obligations with respect to any series of Securities on the 91st day after the applicable
conditions set forth below have been satisfied or (b) the Issuer shall cease to be under any obligation to comply with any term,
provision or condition set forth in Sections 3.08, 3.09, 3.10, and, insofar as such Sections require compliance with Sections 3.08, 3.09
or 3.10, Sections 8.01, 8.02 and 8.03 and non-compliance with such Sections shall not give rise to any Event of Default under Section 4.01(d),
with respect to any series of Securities at any time after the applicable conditions set forth below have been satisfied:


 


(i)          the
Issuer shall have deposited or caused to be deposited irrevocably with the Trustee or its agent as trust funds in trust, specifically
pledged as security for, and dedicated solely to, the benefit of the Holders of the Securities of such series (A) money in an amount,
or (B) Government Obligations of the government in the currency of which the Securities of such series are denominated which through
the payment of interest thereon and principal thereof in accordance with their terms will provide, not later than the due date of any
payment, money in an amount, or (C) a combination of (A) and (B), sufficient, without reinvestment, in the opinion (with respect
to (B) and (C)) of a nationally recognized investment bank, appraisal firm or firm of independent public accountants expressed in
a written certification thereof delivered to the Trustee, to pay and discharge each installment of principal (including mandatory sinking
fund payments) of, and interest on, the outstanding Securities of such series on the dates such installments of interest or principal
are due or to and including the redemption date irrevocably designated by the Issuer pursuant to subparagraph (iv) hereof;


 


(ii)         no
Event of Default or event which with notice or lapse of time would become an Event of Default under Section 4.01(e) or (f) with
respect to the Securities of such series shall have occurred and be continuing on the date of such deposit;


 


(iii)        in
the case of the Securities of such series being discharged pursuant to clause (a) only, the Issuer shall have delivered to the
Trustee an Officers’ Certificate and an Opinion of Counsel each stating that all conditions precedent provided for in this
Indenture relating to the defeasance, have been complied with and an Opinion of Counsel to the effect that the Holders of the debt
securities of that series will not recognize gain or loss for U.S. federal income tax purposes as a result of the defeasance and
will be subject to the same U.S. federal income tax as would be the case if the defeasance did not occur or a ruling to that effect
received from or published by the U.S. Internal Revenue Service;




 






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(iv)        if
the Issuer has deposited or caused to be deposited money or Government Obligations to pay or discharge the principal of and interest
on the Outstanding Securities of a series to and including a redemption date pursuant to subparagraph (i) hereof, such redemption
date shall be irrevocably designated by a Board Resolution delivered to the Trustee on or prior to the date of deposit of such money
or Government Obligations, and such Board Resolution shall be accompanied by an irrevocable Company Order that the Trustee give notice
of such redemption in the name and at the expense of the Issuer not less than 10 nor more than 60 days prior to such redemption date
in accordance with Section 11.02; and


 


(v)         the
Issuer shall have delivered to the Trustee and Officers’ Certificate and an Opinion of Counsel each stating that all conditions
precedent provided for in this Indenture relating to the defeasance, have been complied with.


 


“Discharged”
means that the Issuer shall be deemed to have paid and discharged the entire indebtedness represented by, and obligations under, the
Securities of such series and to have satisfied all the obligations under this Indenture relating to the Securities of such series (and
the Trustee, at the expense of the Issuer, shall execute proper instruments acknowledging the same), except (A) the rights of Holders
of Securities of such series to receive, from the trust fund described in clause (i) above, payment of the principal of and the
interest on such Securities when such payments are due; (B) the Issuer’s obligations, as the case may be, with respect to
such Securities under Sections 2.13, 2.14, 3.03 and 3.05; and (C) the rights, powers, trusts, duties and immunities of the Trustee
hereunder. At such time as the Issuer shall be Discharged with respect to any series of Securities, the Guarantor shall be automatically
and unconditionally released and discharged from all of its obligations under its Guaranty of the Securities of such series and all of
its other obligations under this Indenture in respect of the Securities of such series, without any action by the Issuer, the Guarantor
or the Trustee and without the consent of the Holders of any Securities.


 


Section 9.04     Repayment
of Moneys Held by Paying Agent. In connection with the satisfaction and discharge of this Indenture with respect to Securities of
any series, all moneys then held by any paying agent under the provisions of this Indenture with respect to such series of Securities
shall, upon demand of the Issuer, be repaid to the Issuer or paid to the Trustee and thereupon such paying agent shall be released from
all further liability with respect to such moneys.


 


Section 9.05     Return
of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years. Any moneys deposited with or paid to the Trustee or any paying
agent for the payment of the principal of or interest, if any, on any Security of any series and not applied but remaining unclaimed
for two years after the date upon which such principal or interest shall have become due and payable, shall, upon the written request
of the Issuer and unless otherwise required by mandatory provisions of applicable escheat or abandoned or unclaimed property law, be
repaid to the Issuer by the Trustee for such series or such paying agent, and the Holder of the Security of such series shall, unless
otherwise required by mandatory provisions of applicable escheat or abandoned or unclaimed property laws, thereafter look only to the
Issuer for any payment which such Holder may be entitled to collect, and all liability of the Trustee or any paying agent with respect
to such moneys shall thereupon cease.


 






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Section 9.06     Reinstatement.
If the Trustee is unable to apply any money or Government Obligations in accordance with Section 9.01 or Section 9.03 by reason
of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or otherwise
prohibiting such application, the Issuer’s obligations under this Indenture and the Notes (and the Guarantor’s obligations
under its Guaranty) shall be revived and reinstated as though no deposit had occurred pursuant to Section 9.01 or  9.03, as
the case may be, until such time as the Trustee or Paying Agent is permitted to apply all such money or Government Obligations in accordance
with Section 9.01or 9.03; provided that, if the Issuer or the Guarantor has made any payment of principle of or interest on
the Securities of any series because of the reinstatement of its obligations, the Issuer or the Guarantor, as applicable, shall be subrogated
to the rights of the Holders of such Securities to receive such payment from the money or Government Obligations held by the Trustee
or Paying Agent.


 


Article 10

MISCELLANEOUS PROVISIONS


 


Section 10.01     Incorporators,
Stockholders, Officers and Directors of Issuer and Guarantor Exempt from Individual Liability. No recourse under or upon any obligation,
covenant or agreement contained in this Indenture, including the Guaranty, or in any Security, or because of any indebtedness evidenced
thereby, shall be had against any incorporator, as such, or against any past, present or future stockholder, officer or director, as
such, of the Issuer or the Guarantor or of any successor of the Issuer or the Guarantor, as applicable, either directly or through the
Issuer, the Guarantor or any successor of the Issuer or the Guarantor, as applicable, under any rule of law, statute or constitutional
provision or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being expressly
waived and released by the acceptance of the Securities, including the Guaranty, by the Holders thereof and as part of the consideration
for the issue of the Securities, including the Guaranty. Nothing in this Section shall be deemed to alter the obligations of the
Issuer or the Guarantor under the Securities, including the Guaranty.


 


Section 10.02     Provisions
of Indenture for the Sole Benefit of Parties and Securityholders. Nothing in this Indenture, including the Guaranty, or in the Securities,
expressed or implied, shall give or be construed to give to any Person, other than the parties hereto and their successors and the Holders
of the Securities, any legal or equitable right, remedy or claim under this Indenture or under any covenant or provision herein contained,
all such covenants and provisions being for the sole benefit of the parties hereto and their successors and of the Holders of the Securities.


 


Section 10.03     Successors
and Assigns of Issuer and Guarantor Bound by Indenture. All the covenants, stipulations, promises and agreements in this Indenture
contained by or on behalf of the Issuer shall bind its successors and assigns, whether so expressed or not. All the covenants, stipulations,
promises and agreements in this Indenture and the Guaranty by or on behalf of the Guarantor shall bind its successors and assigns, whether
so expressed or not.


 






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Section 10.04     Notices
and Demands on Issuer, Guarantor, Trustee and Securityholders. Any notice or demand which by any provision of this Indenture is required
or permitted to be given or served by the Trustee or by the Holders of Securities to or on the Issuer or the Guarantor may be given or
served by being deposited postage prepaid, first-class mail or by overnight air courier guaranteeing next day delivery (except as otherwise
specifically provided herein) addressed (until another address of the Issuer or the Guarantor is filed by the Issuer or the Guarantor,
as the case may be, with the Trustee) to AstraZeneca PLC, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA England,
in the case of the Guarantor, and to AstraZeneca Finance LLC, 1209 Orange Street, Wilmington, Delaware 19801, United States of America,
in the case of the Issuer. Any notice, direction, request or demand by the Issuer, the Guarantor or any Securityholder to or upon the
Trustee shall be deemed to have been sufficiently given, made or furnished to or filed with, for all purposes, if given, made or furnished
to or filed with the Trustee at the Corporate Trust Office.


 


Where this Indenture provides
for notice to Holders, such notice shall be sufficiently given (unless otherwise herein expressly provided) if in writing and mailed,
first-class postage prepaid, to each Holder entitled thereto, at his last address as it appears in the Security register. In any case
where notice to Holders is given by mail, neither the failure to mail such notice, nor any defect in any notice so mailed, to any particular
Holder shall affect the sufficiency of such notice with respect to other Holders. Where this Indenture provides for notice in any manner,
such notice may be waived in writing by the person entitled to receive such notice, either before or after the event, and such waiver
shall be the equivalent of such notice. Waivers of notice by Holders shall be filed with the Trustee, but such filing shall not be a
condition precedent to the validity of any action taken in reliance upon such waiver. For so long as the Securities of any series are
represented by Global Securities, notices with respect to such series shall be delivered to the Depositary according to the applicable
procedures of such Depository, if any, prescribed for the giving of such notice.


 


In case, by reason of the
suspension of or irregularities in regular mail service, it shall be impracticable to mail notice to the Issuer, the Guarantor and Securityholders
when such notice is required to be given pursuant to any provision of this Indenture, then any manner of giving such notice as shall
be satisfactory to the Trustee shall be deemed to be a sufficient giving of such notice.


 


Section 10.05     Officers’
Certificates and Opinions of Counsel; Statements to be Contained Therein. Upon any application or demand by the Issuer to the Trustee
to take any action under any of the provisions of this Indenture, the Issuer shall furnish to the Trustee an Officers’ Certificate
stating that all conditions precedent provided for in this Indenture relating to the proposed action have been complied with and an Opinion
of Counsel stating that in the opinion of such counsel such action is authorized or permitted by this Indenture and that all such conditions
precedent have been complied with, except that in the case of any such application or demand as to which the furnishing of such documents
is specifically required by any provision of this Indenture relating to such particular application or demand, no additional certificate
or opinion need be furnished.


 


Each certificate or opinion
provided for in this Indenture and delivered to the Trustee with respect to compliance with a condition or covenant provided for in this
Indenture shall include (a) a statement that the person making such certificate or opinion has read such covenant or condition,
(b) a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained
in such certificate or opinion are based, (c) a statement that, in the opinion of such person, he or she has made such examination
or investigation as is necessary to enable him or her to express an informed opinion as to whether or not such covenant or condition
has been complied with and (d) a statement as to whether or not, in the opinion of such person, such condition or covenant has been
complied with.


 






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Any certificate, statement
or opinion of an officer of the Issuer may be based, insofar as it relates to legal matters, upon a certificate or opinion of or representations
by counsel, unless such officer knows that the certificate or opinion or representations with respect to the matters upon which his certificate,
statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous.
Any certificate, statement or opinion of counsel may be based, insofar as it relates to factual matters, information with respect to
which is in the possession of the Issuer, upon the certificate, statement or opinion of or representations by an officer or officers
of the Issuer, unless such counsel knows that the certificate, statement or opinion or representations with respect to the matters upon
which his certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know
that the same are erroneous.


 


Any certificate, statement
or opinion of an officer of the Issuer or of counsel may be based, insofar as it relates to accounting matters, upon a certificate or
opinion of or representations by an accountant or firm of accountants in the employ of the Issuer, unless such officer or counsel, as
the case may be, knows that the certificate or opinion or representations with respect to the accounting matters upon which his certificate,
statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous.


 


Any certificate or opinion
of any independent firm of public accountants filed with the Trustee shall contain a statement that such firm is independent.


 


Section 10.06     Payments
Due on Saturdays, Sundays and Holidays. If the date of maturity of interest on or principal of the Securities of any series or the
date fixed for redemption or repayment of any such Security shall not be a Business Day, then payment of interest or principal need not
be made on such date, but may be made on the next succeeding Business Day with the same force and effect as if made on the date of maturity
or the date fixed for redemption, and no interest shall accrue for the period after such date.


 


Section 10.07     Conflict
of any Provision of Indenture with Trust Indenture Act of 1939. If and to the extent that any provision of this Indenture limits,
qualifies or conflicts with another provision included in this Indenture by operation of sections 310 to 317, inclusive, of the Trust
Indenture Act of 1939 (an “incorporated provision”), such incorporated provision shall control.


 


Section 10.08     New
York Law to Govern; Waiver of Jury Trial. This Indenture, including the Guaranty, and each Security shall be deemed to be a contract
under the laws of the State of New York, and for all purposes shall be construed in accordance with the laws of such State, except as
may otherwise be required by mandatory provisions of law.


 


EACH OF THE ISSUER, THE GUARANATOR
AND THE TRUSTEE, AND EACH HOLDER OF A SECURITY BY ITS ACCEPTANCE THEREOF, HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED
BY APPLICABLE LAW, ANY AND ALL RIGHT IT MAY HAVE TO TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF
OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY.


 






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Section 10.09     Counterparts.
This Indenture may be executed in any number of counterparts, each of which shall be an original; but such counterparts shall together
constitute but one and the same instrument.


 


The exchange of copies of
this Indenture and of signature pages by facsimile or electronic (i.e.,
 “pdf” or “tif”) transmission shall constitute effective execution and delivery of this Indenture as to
the parties hereto and may be used in lieu of the original Indenture for all purposes. The exchange of copies of this Indenture and of
signature pages that are executed by manual signatures that are scanned or photocopied or using other electronic format (including,
without limitation, “pdf,” “tif” or “jpg”) or by other electronic signing created on an electronic
platform (such as DocuSign) or by digital signing (such as Adobe Sign), in each case that is approved by the Trustee, shall constitute
effective execution and delivery of this Indenture for all purposes. Signatures of the parties hereto that are executed by manual signatures
that are scanned or photocopied or using other electronic format (including, without limitation, “pdf,” “tif”
or “jpg”) or by other electronic signing created on an electronic platform (such as DocuSign) or by digital signing (such
as Adobe Sign), in each case that is approved by the Trustee, shall be deemed to be their original signatures for all purposes of this
Indenture as to the parties hereto and may be used in lieu of the original Indenture.


 


Anything in this Indenture
or the Securities of any series to the contrary notwithstanding, for the purposes of the transactions contemplated by this Indenture,
the Securities of any series and any document to be signed in connection with the Indenture or the Securities of any series (including
the Securities, the Trustee’s certificate of authentication on the Securities and amendments, supplements, waivers, consents and
other modifications, Officers’ Certificates, Company Orders and Opinions of Counsel and other issuance, authentication and delivery
documents) or the transactions contemplated hereby may be signed by manual signatures that are scanned or photocopied or using other
electronic format (including, without limitation, “pdf,” “tif” or “jpg”) or other electronic signatures
created on an electronic platform (such as DocuSign) or by digital signature (such as Adobe Sign), in each case that is approved by the
Trustee, and contract formations on electronic platforms approved by the Trustee, and the keeping of records in electronic form (including,
without limitation, any contract or other record created, generated, sent, communicated, received, or stored by electronic means), are
hereby authorized, and each shall be of the same legal effect, validity or enforceability as a manually executed signature in ink or
the use of a paper-based recordkeeping system, as the case may be.


 


Section 10.10     Effect
of Headings. The Article and Section headings herein and the Table of Contents are for convenience only and shall not affect
the construction hereof.


 


Section 10.11     Submission
to Jurisdiction. Each of the Issuer and the Guarantor agrees that any legal suit, action or proceeding arising out of or relating
to this Indenture or the Securities (or the Guaranty) may be instituted in any state or federal court in the State and County of New
York, United States of America, waives to the extent it may effectively do so, any objection which it may have now or hereafter to the
laying of the venue of any such suit, action or proceeding, and irrevocably submits to the jurisdiction of any such court in any such
suit, action or proceeding. The Guarantor hereby designates CT Corporation System as the Guarantor’s authorized agent to accept
and acknowledge on its behalf service of any and all process which may be served in any such suit, action or proceeding in any such court
and agrees that service of process upon said agent at its office at 28 Liberty Street, New York, New York 10005 (or at such other address
in the Borough of Manhattan, The City of New York, as such agent may designate by written notice to the Issuer and the Trustee), and
written notice of said service to the Guarantor, mailed or delivered to them, at 1 Francis Crick Avenue, Cambridge Biomedical Campus,
Cambridge CB2 0AA England, attention of the Secretary (until another address of the Issuer or the Guarantor is filed by the Issuer or
the Guarantor with the Trustee) shall be deemed in every respect effective service of process upon the Guarantor in any such suit, action
or proceeding and shall be taken and held to be valid personal service upon the Guarantor, whether or not the Guarantor shall then be
doing, or at any time shall have done, business within the State of New York, and that any such service of process shall be of the same
force and validity as if service were made upon it according to the laws governing the validity and requirements of such service in such
state, and waives all claim of error by reason of any such service. Said designation and appointment shall be irrevocable until this
Indenture shall have been satisfied and discharged in accordance with Article 9.


 






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Section 10.12     Electronic
Means.


 


(a)          The
Trustee shall have the right to accept and act upon instructions, including funds transfer instructions (“Instructions”)
given pursuant to this Indenture and delivered using Electronic Means; provided, however, that the Issuer shall provide to the Trustee
an incumbency certificate listing officers with the authority to provide such Instructions (“Authorized Officers”)
and containing specimen signatures of such Authorized Officers, which incumbency certificate shall be amended by the Issuer whenever
a person is to be added or deleted from the listing. If the Issuer elects to give the Trustee Instructions using Electronic Means and
the Trustee in its discretion elects to act upon such Instructions, the Trustee’s understanding of such Instructions shall be deemed
controlling. The Issuer understands and agrees that the Trustee cannot determine the identity of the actual sender of such Instructions
and that the Trustee shall conclusively presume that directions that purport to have been sent by or on behalf of an Authorized Officer
listed on the incumbency certificate provided to the Trustee have been sent by or on behalf of such Authorized Officer. The Issuer shall
be responsible for ensuring that only Authorized Officers (or employees of the Issuer or the Guarantor acting on behalf of Authorized
Officers) transmit such Instructions to the Trustee and that the Issuer and all Authorized Officers are solely responsible to safeguard
the use and confidentiality of applicable user and authorization codes, passwords and/or authentication keys upon receipt by the Issuer.


 


(b)          The
Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee’s reliance upon and
compliance with such Instructions notwithstanding such directions conflict or are inconsistent with a subsequent written instruction.
The Issuer agrees: (i) to assume all risks arising out of the use of Electronic Means to submit Instructions to the Trustee, including
without limitation the risk of the Trustee acting on unauthorized Instructions, and the risk of interception and misuse by third parties;
(ii) that it is fully informed of the protections and risks associated with the various methods of transmitting Instructions to
the Trustee and that there may be more secure methods of transmitting Instructions than the method(s) selected by the Issuer; (iii) that
the security procedures (if any) to be followed in connection with its transmission of Instructions provide to it a commercially reasonable
degree of protection in light of its particular needs and circumstances; and (iv) to notify the Trustee immediately upon learning
of any compromise or unauthorized use of the security procedures.


 






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(c)          “Electronic
Means” shall mean the following communications methods: e-mail, secure electronic transmission containing applicable authorization
codes, passwords and/or authentication keys issued by the Trustee, or another method or transmission system as may be agreed upon by
the Issuer and the Trustee in connection with its services hereunder.


 


Section 10.13     Force
Majeure. The Trustee shall not be responsible or liable for any failure or delay in the performance of its obligations under this
Indenture to the extent caused, directly or indirectly, by natural disasters, fire, acts of God, strikes or other labor disputes, work
stoppages, acts of war or terrorism, general civil unrest, actual or threatened epidemics or pandemics, disease, act of any government,
governmental authority or police or military authority, declared or threatened state of emergency, legal constraint, the interruption,
loss or malfunction of utilities or transportation, communications or computer systems, or any other similar events beyond its reasonable
control.


 


Section 10.14     Consequential
Damages. Anything in this Indenture notwithstanding, in no event shall the Trustee be liable for special, indirect, punitive or consequential
or other similar loss or damage of any kind whatsoever (including but not limited to loss of profit) except to the extent any such special,
indirect, punitive or consequential or other similar loss or damage may arise from the Trustee’s own negligence, bad faith or willful
misconduct, even if the Trustee has been advised as to the likelihood of such loss or damage and regardless of the form of action.


 


Article 11

REDEMPTION OF SECURITIES AND SINKING FUNDS


 


Section 11.01     Applicability
of Article. The provisions of this Article shall be applicable to the Securities of any series which are redeemable before their
maturity or to any sinking fund for the retirement of Securities of a series except as otherwise specified as contemplated by Section 2.08
for Securities of such series.


 


Section 11.02     Notice
of Redemption; Partial Redemptions. Notice of redemption to the Holders of Securities of any series to be redeemed as a whole
or in part at the option of the Issuer shall be given by mailing notice of such redemption by first class mail, postage prepaid, or as
otherwise provided by the customary practices and procedures of the Depositary including through electronic delivery, at least 10 days
and not more than 60 days prior to the date fixed for redemption to such Holders of Securities of such series at their last addresses
as they shall appear upon the registry books. Any notice which is mailed or otherwise provided in the manner set forth herein shall be
conclusively presumed to have been duly given, whether or not the Holder receives the notice. Failure to give notice by mail or as otherwise
provided in the manner set forth herein, or any defect in the notice to the Holder of any Security of a series designated for redemption
as a whole or in part shall not affect the validity of the proceedings for the redemption of any other Security of such series.


 


The notice of redemption
to each such Holder shall specify the principal amount of each Security of such series held by such Holder to be redeemed, the date fixed
for redemption, the redemption price, the place or places of payment, that payment will be made upon presentation and surrender of such
Securities, that such redemption is pursuant to the mandatory or optional sinking fund, or both, if such be the case, or that such redemption
is pursuant to Section 11.06(a) or Section 11.06(b), that interest accrued to the date fixed for redemption will be paid
as specified in such notice, that on and after said date interest thereon or on the portions thereof to be redeemed will cease to accrue
and, if such notice of redemption is conditional in accordance with the second succeeding paragraph, a statement of the conditions to
such redemption. In case any Security of a series is to be redeemed in part only, the notice of redemption shall state the portion of
the principal amount thereof to be redeemed and shall state that on and after the date fixed for redemption, upon surrender of such Security,
a new Security or Securities of such series, in principal amount equal to the unredeemed portion thereof will be issued.


 






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The notice of redemption
of Securities of any series to be redeemed at the option of the Issuer shall be given by the Issuer or, at the Issuer’s request,
by the Trustee in the name and at the expense of the Issuer; provided, however, that the Issuer has delivered to the Trustee, at least
10 days (unless a shorter period shall be acceptable to the Trustee) prior to the redemption date, an Officers’ Certificate requesting
that the Trustee give such notice and setting forth the information to be stated in such notice.


 


A notice of redemption may
be conditional and provide that it is subject to the occurrence of any event described in the notice before the date fixed for the redemption
(even if such event occurs more than 60 days after the delivery of the notice of redemption). A notice of conditional redemption will
be of no effect unless all conditions to the redemption have occurred before the redemption date or have been waived by the Issuer.


 


On the redemption date specified
in the notice of redemption given as provided in this Section, the Issuer will deposit with the Trustee or with one or more paying agents
(or, if the Issuer is acting as its own paying agent, set aside, segregate and hold in trust as provided in Section 3.05) an amount
of money sufficient to redeem on the redemption date all the Securities of such series so called for redemption at the appropriate redemption
price, together with accrued interest to the date fixed for redemption. If less than all the outstanding Securities of a series are to
be redeemed, the Issuer will deliver to the Trustee at least 10 days prior to the date fixed for redemption, or such other period as
shall be agreed by the Trustee, an Officers’ Certificate stating the aggregate principal amount of Securities to be redeemed.


 


If fewer than all the Securities
of a series are to be redeemed, the Trustee shall select the Securities of such series to be redeemed in whole or in part by lot or by
any other method the Trustee considers fair and appropriate, subject to any securities exchange requirements (provided that, in the case
of Global Securities, the Depositary may select beneficial interests in Global Securities for redemption pursuant to its applicable procedures).
Securities may be redeemed in part in principal amounts equal to the minimum authorized denomination for Securities of such series or
any multiple thereof. The Trustee shall promptly notify the Issuer in writing of the Securities of such series selected for redemption
and, in the case of any Securities of such series selected for partial redemption, the principal amount thereof to be redeemed. For all
purposes of this Indenture, unless the context otherwise requires, all provisions relating to the redemption of Securities of any series
shall relate, in the case of any Security redeemed or to be redeemed only in part, to the portion of the principal amount of such Security
which has been or is to be redeemed.


 


Section 11.03     Payment
of Securities Called for Redemption. If notice of redemption has been given as provided above, the Securities or portions of Securities
specified in such notice shall become due and payable on the date and at the place stated in such notice at the applicable redemption
price, together with interest accrued to the date fixed for redemption, and on and after said date (unless the Issuer shall default in
the payment of such Securities at the redemption price, together with interest accrued, if any, to said date) interest on the Securities
or portions of Securities so called for redemption shall cease to accrue and, except as provided in Sections 5.05 and 9.05, such Securities
shall cease from and after the date fixed for redemption to be entitled to any benefit or security under this Indenture, and the Holders
thereof shall have no right in respect of such Securities except the right to receive the redemption price thereof and unpaid interest
to the date fixed for redemption. On presentation and surrender of such Securities at a place of payment specified in said notice, said
Securities or the specified portions thereof shall be paid and redeemed by the Issuer at the applicable redemption price, together with
interest accrued thereon to the date fixed for redemption; provided that any semi-annual payment of interest becoming due on the
date fixed for redemption shall be payable to the Holders of such Securities registered as such on the relevant record date subject to
the terms and provisions of Section 2.12.


 






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If any Security called for
redemption shall not be so paid upon surrender thereof for redemption, the principal shall, until paid or duly provided for, bear interest
from the date fixed for redemption at the rate of interest or Yield to Maturity (in the case of an Original Issue Discount Security)
borne by the Security.


 


Upon presentation of any
Security redeemed in part only, the Issuer and Guarantor shall execute and the Trustee shall authenticate and deliver to or on the order
of the Holder thereof, at the expense of the Issuer, a new Security or Securities of such series, of authorized denominations, in principal
amount equal to the unredeemed portion of the Security so presented.


 


The Issuer will notify the
Trustee of the redemption price of any series Securities to be redeemed promptly after the calculation thereof, and the Trustee shall
not be responsible or liable for any such calculation.


 


Section 11.04     Exclusion
of Certain Securities from Eligibility for Selection for Redemption. Securities shall be excluded from eligibility for selection
for redemption if they are identified by registration and certificate number in a written statement signed by an Authorized Officer of
the Issuer and delivered to the Trustee at least 5 days prior to the last date on which notice of redemption may be given, or such other
period as may be agreed by the Trustee, as being owned of record and beneficially by, and not pledged or hypothecated by either (a) the
Issuer or (b) an entity specifically identified in such written statement as directly or indirectly controlling or controlled by
or under direct or indirect common control with the Issuer.


 


Section 11.05     Mandatory
and Optional Sinking Funds. The minimum amount of any sinking fund payment provided for by the terms of Securities of any series
is herein referred to as a “mandatory sinking fund payment,” and any payment in excess of such minimum amount provided for
by the terms of Securities of any series is herein referred to as an “optional sinking fund payment.” The date on which a
sinking fund payment is to be made is herein referred to as the “sinking fund payment date.”


 


In lieu of making all or
any part of any mandatory sinking fund payment with respect to any series of Securities in cash, the Issuer may at its option (a) deliver
to the Trustee Securities of such series theretofore purchased or otherwise acquired (except upon redemption pursuant to the mandatory
sinking fund) by the Issuer or receive credit for Securities of such series (not previously so credited) theretofore purchased or otherwise
acquired (except as aforesaid) by the Issuer and delivered to the Trustee for cancellation pursuant to Section 2.15, (b) receive
credit for optional sinking fund payments (not previously so credited) made pursuant to this Section, or (c) receive credit for
Securities of such series (not previously so credited) redeemed by the Issuer through any optional redemption provision contained in
the terms of such series. Securities so delivered or credited shall be received or credited by the Trustee at the sinking fund redemption
price specified in such Securities.


 






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On or before the sixtieth
day next preceding each sinking fund payment date for any series, the Issuer will deliver to the Trustee a written statement (which need
not contain the statements required by Section 10.05) signed by an Authorized Officer of the Issuer (a) specifying the portion
of the mandatory sinking fund payment to be satisfied by payment of cash and the portion to be satisfied by credit of Securities of such
series, (b) stating that none of the Securities of such series has theretofore been so credited, (c) stating that no defaults
in the payment of interest, if any, or Events of Default with respect to such series have occurred (which have not been waived or cured)
and are continuing and (d) stating whether or not the Issuer intends to exercise its right to make an optional sinking fund payment
with respect to such series and, if so, specifying the amount of such optional sinking fund payment which the Issuer intends to pay on
or before the next succeeding sinking fund payment date. Any Securities of such series to be credited and required to be delivered to
the Trustee in order for the Issuer to be entitled to credit therefor as aforesaid which have not theretofore been delivered to the Trustee
shall be delivered for cancellation pursuant to Section 2.15 to the Trustee with such written statement (or reasonably promptly
thereafter if acceptable to the Trustee). Such written statement shall be irrevocable and upon its receipt by the Trustee the Issuer
shall become unconditionally obligated to make all the cash payments or payments therein referred to, if any, on or before the next succeeding
sinking fund payment date. Failure of the Issuer, on or before any such sixtieth day, to deliver such written statement and Securities
specified in this paragraph, if any, shall not constitute a default but shall constitute, on and as of such date, the irrevocable election
of the Issuer (i) that the mandatory sinking fund payment for such series due on the next succeeding sinking fund payment date shall
be paid entirely in cash without the option to deliver or credit Securities of such series in respect thereof and (ii) that the
Issuer will make no optional sinking fund payment with respect to such series as provided in this Section.


 


If the sinking fund payment
or payments (mandatory or optional or both) to be made in cash on the next succeeding sinking fund payment date plus any unused balance
of any preceding sinking fund payments made in cash shall exceed $50,000 (or a lesser sum if the Issuer shall so request) with respect
to the Securities of any particular series, such cash shall be applied on the next succeeding sinking fund payment date to the redemption
of Securities of such series at the sinking fund redemption price together with accrued interest to the date fixed for redemption. If
such amount shall be $50,000 or less and the Issuer makes no such request then it shall be carried over until a sum in excess of $50,000
is available. The Trustee shall select, in the manner provided in Sections 11.02 and 11.04, for redemption on such sinking fund payment
date a sufficient principal amount of Securities of such series to absorb said cash, as nearly as may be, and shall (if requested in
writing by the Issuer) inform the Issuer of the serial numbers of the Securities of such series (or portions thereof) so selected. The
Trustee, in the name and at the expense of the Issuer (or the Issuer, if it shall so request the Trustee in writing) shall cause notice
of redemption of the Securities of such series to be given in substantially the manner provided in Section 11.02 (and with the effect
provided in Section 11.03) for the redemption of Securities of such series in part at the option of the Issuer. The amount of any
sinking fund payments not so applied or allocated to the redemption of Securities of such series shall be added to the next cash sinking
fund payment for such series and, together with such payment, shall be applied in accordance with the provisions of this Section. Any
and all sinking fund moneys held on the stated maturity date of the Securities of any particular series (or earlier, if such maturity
is accelerated), which are not held for the payment or redemption of particular Securities of such series shall be applied, together
with other moneys, if necessary, sufficient for the purpose, to the payment of the principal of, and interest on, the Securities of such
series at maturity.


 






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On each sinking fund payment
date, the Issuer shall pay to the Trustee in cash or shall otherwise provide for the payment of all interest accrued to the date fixed
for redemption on Securities to be redeemed on the next following sinking fund payment date.


 


The Trustee shall not redeem
or cause to be redeemed any Securities of a series with sinking fund moneys or mail any notice of redemption of Securities for such series
by operation of the sinking fund during the continuance of a default in payment of interest on such Securities or of any Event of Default
except that, where the mailing of notice of redemption of any Securities shall theretofore have been made, the Trustee shall redeem or
cause to be redeemed such Securities; provided that it shall have received from the Issuer a sum sufficient for such redemption. Except
as aforesaid, any moneys in the sinking fund for such series at the time when any such default or Event of Default shall occur, and any
moneys thereafter paid into the sinking fund, shall, during the continuance of such default or Event of Default, be deemed to have been
collected under Article 4 and held for the payment of all such Securities. In case such Event of Default shall have been waived
as provided in Section 4.10 or the default cured on or before the sixtieth day preceding the sinking fund payment date in any year,
such moneys shall thereafter be applied on the next succeeding sinking fund payment date in accordance with this Section to the
redemption of such Securities.


 


Section 11.06     Optional
Redemption Due to Changes in Tax Treatment. (a) Unless otherwise provided in the Securities of the relevant series, if:


 


(i) as the result of
any change in or any amendment to the laws or any regulations or rulings promulgated thereunder of the Relevant Taxing Jurisdiction of
the Issuer or the Guarantor or of any political subdivision or taxing authority thereof or therein, or any change in an application or
interpretation of such laws, regulations or rulings, or any change in an application or interpretation of, or any execution of an amendment
to, any treaty or treaties affecting taxation to which such Relevant Taxing Jurisdiction or any political subdivision thereof is a party,
which change, amendment, application, interpretation or execution becomes effective on or after the date specified for such
series pursuant to Section 2.08, or


 


(ii) as a result of
any action taken by any taxing authority of, or any action brought in a court of competent jurisdiction in, such jurisdiction described
above or any political subdivision thereof (whether or not such action was taken or brought with respect to the Issuer or the Guarantor),
which action is taken or brought on or after the date specified for such series pursuant to Section 2.08, or


 






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(iii) as a result of
any delivery or of any requirement to deliver definitive Registered Securities (having used all reasonable efforts to avoid having to
issue such definitive Registered Securities),


 


either:


 


(x) the Issuer
or the Guarantor is or would be required to pay additional amounts with respect to the Securities, on the next succeeding Interest Payment
Date; or


 


(y) any Subsidiary
of the Issuer or the Guarantor is or would be required to deduct or withhold tax on any payment to the Issuer or the Guarantor to enable
the Issuer or the Guarantor to make any payment of principal or interest in respect of the Securities,


 


and in either case the payment of such
additional amounts in the case of (x) above or such deduction or withholding in the case of (y) above cannot be avoided by
the use of any reasonable measures available to the Issuer or the Guarantor, or


 


(iv) the Person formed by a consolidation of the Issuer or Guarantor,
as applicable, or into which the Issuer or Guarantor, as applicable, is merged or to which the Issuer or the Guarantor, as applicable,
conveys, transfers or leases its properties and assets substantially as an entirety is required to pay a Holder of a Security additional
amounts in respect of any tax, assessment or governmental charge which is imposed on any such Holder or required to be withheld or deducted
from any payment to such Holder as a consequence of such consolidation, merger, conveyance, transfer or lease,


 


the Issuer may, at its option, redeem such series of
Securities in whole at any time (except in the case of a series having a variable rate of interest, which may be redeemed on any
interest payment date) at a redemption price equal to 100 per cent of the principal amount thereof plus accrued interest to the date
fixed for redemption (except in the case of Outstanding Original Issue Discount Securities which may be redeemed at the redemption
price specified by the terms of each series of such Securities). Prior to any redemption of such a series of Securities pursuant to
this Section 11.06(a), the Issuer shall provide the Trustee with an Opinion of Counsel that the conditions precedent to the
right of the Issuer to redeem such Securities pursuant to this Section 11.06(a) have occurred. Such Opinion of Counsel
shall be based on the laws in effect on the date of such opinion or to become effective on or before the next succeeding date for
payment of principal or interest.


 


(b)          Unless
otherwise provided in the Securities of the relevant series, if (1) there has been an amalgamation, reconstruction, consolidation,
merger or other transaction concerning the Issuer or the Guarantor permitted by Section 8.01 or Section 12.04 and (2) as
the result of: (i) any change in or any amendment to the laws or any regulations or rulings thereunder of the jurisdiction in which
such successor Issuer or successor Guarantor is resident for tax purposes (and, if such successor Issuer or successor Guarantor is, or
is treated as, a “domestic corporation” for U.S. federal income tax purposes, such successor Issuer or successor Guarantor
shall be treated as a “resident” of the United States for U.S. federal income tax purposes) or of any political subdivision
or taxing authority thereof or therein affecting taxation, or any change in an application or interpretation of such laws, regulations
or rulings, or any change in an application or interpretation of, or any execution of an amendment to, any treaty or treaties affecting
taxation to which such jurisdiction or any political subdivision thereof is a party, which change, amendment,
application, interpretation or execution becomes effective on or after the date of such transaction or assumption, or (ii) any action
taken by any taxing authority of, or any action brought in a court of competent jurisdiction in such jurisdiction or any political subdivision
thereof (whether or not such action was taken or brought with respect to the successor Issuer or the successor Guarantor), which action
is taken or brought on or after the date of such transaction or assumption, or (iii) any delivery or of any requirement to deliver
definitive Registered Securities (having used all reasonable efforts to avoid having to issue such definitive Registered Securities),
either (1) the successor Issuer or the successor Guarantor is or would be required to pay additional amounts with respect to the
Securities, on the next succeeding Interest Payment Date, or (2) any Subsidiary of the successor Issuer or the successor Guarantor
is or would be required to deduct or withhold tax on any payment to the successor Issuer or the successor Guarantor to enable the successor
Issuer or the successor Guarantor to make any payment of principal or interest in respect of the Securities, and in either case the payment
of such additional amounts in the case of (1) above or such deduction or withholding in the case of (2) above cannot be avoided
by the use of any reasonable measures available to the successor Issuer or the successor Guarantor, the Issuer or the successor Issuer
(as the case may be) may, at its option, redeem such series of Securities in whole at any time (except in the case of a series having
a variable rate of interest, which may be redeemed on any interest payment date) at a redemption price equal to 100 per cent of the principal
amount thereof plus accrued interest to the date fixed for redemption (except in the case of Outstanding Original Issue Discount Securities
which may be redeemed at the redemption price specified by the terms of each series of such Securities). Prior to any redemption of such
a series of Securities pursuant to this Section 11.06(b), the Issuer or the successor Issuer (as the case may be) shall provide
the Trustee with an Opinion of Counsel that the conditions precedent to the right of the Issuer or the successor Issuer (as the case
may be) to redeem such Securities pursuant to this Section 11.06(b) have occurred. Such Opinion of Counsel shall be based on
the laws in effect on the date of such opinion or to become effective on or before the next succeeding date for payment of principal
or interest.


 






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Article 12

GUARANTY


 


Section 12.01     Guaranty
of Issuer’s Securities. The Guarantor hereby fully and unconditionally guarantees to each Holder of a Security authenticated
and delivered by the Trustee (a) the prompt payment by the Issuer of the outstanding principal of such Security when and as the
same shall become due, whether at the stated maturity thereof, by acceleration or otherwise, (b) the prompt payment by the Issuer
of any interest and any premium, payable with respect to the outstanding principal of such Security when and as the same shall become
due, whether at the stated maturity thereof, by acceleration or otherwise and (c) the payment of all other sums owing from the Issuer
under such Security and this Indenture when and as the same shall become due. The payment obligations identified in subparagraphs (a) through
(c) being collectively referred to herein as the “Guaranteed Obligations.” All payments by the Guarantor shall
be made in lawful money of the United States of America. The Guaranty shall be unsecured and shall rank equally with other unsecured
and unsubordinated indebtedness for borrowed money of the Guarantor.


 


Section 12.02     Unconditional
Nature of Obligations. Except as otherwise provided in Section 12.07 of this Guaranty, the obligations of the Guarantor under
this Guaranty shall be absolute and unconditional and shall remain in full force and effect until the entire Guaranteed Obligations shall
have been paid, and except as specifically otherwise provided in this Guaranty, such obligation shall not be affected, modified or impaired
upon the happening from time to time of any event, including without limitation any of the following, whether or not with notice to,
or the consent of, the Guarantor:


 


		(1)	the waiver, surrender, compromise, settlement,
                                            release or termination of any or all of the obligations, covenants or agreements of the Issuer
                                            under the Security of any series;



 






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		(2)	the failure to give notice to the Guarantor
                                            of the occurrence of an Event of Default with respect to a Security of any series;



 


		(3)	the waiver, compromise or release of the
                                            payment, performance or observance by the Issuer or by the Guarantor, respectively, of any
                                            or all of the obligations, covenants or agreements of either of them contained in a Security
                                            of any series or the Guaranty, as the case may be;



 


		(4)	the extension of the time for payment
                                            of any principal or interest or for any other payment under a Security of any series or of
                                            the time for performance of any other obligations, covenants or agreements under or arising
                                            out of this Indenture;



 


		(5)	the modification, amendment or alteration
                                            (whether material or otherwise) of any obligation, covenant or agreement applicable to a
                                            Security of any series;



 


		(6)	the taking or the omission of any of the
                                            actions referred to in a Security of any series, including any acceleration of sums owing
                                            thereunder;



 


		(7)	any failure, omission, delay or lack on
                                            the part of a Holder or the Trustee to enforce, assert or exercise any right, power or remedy
                                            conferred on it with respect to such Security of any series or any other circumstance which
                                            might otherwise constitute a legal or equitable discharge or defense of the Guarantor;



 


		(8)	the voluntary or involuntary liquidation,
                                            dissolution, sale or other disposition of all or substantially all the assets, marshalling
                                            of assets and liabilities, receivership, insolvency, bankruptcy, assignment for the benefit
                                            of creditors, reorganization, arrangement, composition with creditors or readjustment of,
                                            or other similar proceedings affecting the Guarantor or the Issuer or any of the respective
                                            assets of either of them, or any allegation or contest of the validity of this Guaranty in
                                            any such proceeding and shall, to the fullest extent permitted by law, continue to be effective
                                            or be reinstated, as the case may be, if at any time payment and performance of a Security
                                            of any series are, pursuant to applicable law, rescinded or reduced in amount, or must otherwise
                                            be restored or returned by any obligee on such Security or the Guaranty, whether as a “voidable
                                            preference,” “fraudulent transfer” or otherwise, all as though such payment
                                            or performance had not been made;



 


		(9)	any defense based upon any legal disability
                                            of the Issuer or, to the extent permitted by law, any release, discharge, reduction or limitation
                                            of or with respect to any sums owing by the Issuer or any other liability of the Issuer to
                                            a Holder or the Trustee;



 


		(10)	to the extent permitted by law, the release
                                            or discharge by operation of law of the Guarantor from the performance or observance of any
                                            obligation, covenant or agreement contained in this Guaranty;



 


		(11)	the default or failure of the Guarantor
                                            fully to perform any of its obligations set forth in this Guaranty; or



 





		(12)	the invalidity of the Security of any
                                            series or any part thereof or any defense which the Issuer may have against a Holder or the
                                            Trustee.


 






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For the avoidance of doubt,
the Guarantor hereby waives diligence, presentment, demand of payment, filing of claims with a court in the event of insolvency or bankruptcy
of the Issuer, any right to require a proceeding first against the Issuer, protest, notice and all demands whatsoever.


 


If any payment by the Issuer
to the Trustee or a Holder is rescinded or must be returned by the Trustee or such Holder, as applicable, the obligations of the Guarantor
hereunder shall be reinstated with respect to such payment.


 


No set-off, counterclaim,
reduction, or diminution of any obligation, or any defense of any kind or nature which the Guarantor has or may have against the Trustee
or a Holder shall be available hereunder to the Guarantor against the Trustee or such Holder to reduce the payments to it under Section 12.01.


 


The Guarantor assumes responsibility
for being and remaining informed of the financial condition of the Issuer and of all other circumstances bearing upon the risk of non-payment
of amounts owing under any series of the Securities which diligent inquiry would reveal and agrees that neither the Trustee nor any Holder
shall have a duty to advise the Guarantor of information known to it regarding such condition or any such circumstances.


 


In the event of a default
in the payment of the amounts guaranteed pursuant to the terms hereof when and as the same shall become due, the Guarantor is obligated
to make the scheduled payment immediately and, if it does not, the Trustee (on behalf of the Holders of the Securities) shall have the
right to proceed first and directly against the Guarantor under the Guaranty without proceeding against the Issuer or exhausting any
other remedies which it may have.


 


Section 12.03     Costs.
The Guarantor agrees to pay all costs, expenses and fees, including all reasonable attorneys’ fees, which may be incurred by the
Trustee in enforcing or attempting to enforce this Guaranty following any default on the part of the Guarantor hereunder, whether the
same shall be enforced by suit or otherwise.


 






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Section 12.04     Consolidation,
Merger, Sale of Assets.


 


(a)          Nothing
contained in this Indenture or in any of the Securities shall prevent any amalgamation, reconstruction, consolidation or merger of the
Guarantor with or into any other Person (whether or not affiliated with the Guarantor), or successive amalgamations, reconstructions,
consolidations or mergers in which the Guarantor or its successor or successors shall be a party or parties, or shall prevent any sale
or conveyance of the property of the Guarantor as an entirety or substantially as an entirety, to any other Person (whether or not affiliated
with the Guarantor) authorized to acquire and operate the same; provided, however, that the Person formed by such amalgamation, restructuring
or consolidation, or into which the Guarantor shall merge, or which shall acquire such property is organized and validly existing under
the laws of a State of the United States, the United Kingdom or another jurisdiction that is a member country of the Organization for
Economic Cooperation and Development (or any successor thereto) and provided further that the Guarantor hereby covenants and agrees that,
upon any such amalgamation, reconstruction, consolidation, merger, sale or conveyance, (i) the due and punctual performance and observance
of all of the covenants and conditions of this Indenture to be performed by the Guarantor (including, if applicable, submission to jurisdiction),
shall be expressly assumed by supplemental indenture satisfactory in form to the Trustee, executed and delivered to the Trustee, by the
Person formed by such amalgamation, reconstruction or consolidation, or into which the Guarantor shall have been merged, or by the Person
which shall have acquired such property, and (ii) if the Person formed by such amalgamation, reconstruction or consolidation, or
into which the Guarantor shall have been merged, or which shall have acquired such property, is resident for tax purposes other than in
the United Kingdom (and, if such Person is, or is treated as, a “domestic corporation” for U.S. federal income tax purposes,
such successor Person shall be treated as a “resident” of the United States for U.S. federal income tax purposes), such Person
shall, in such supplemental indenture, agree that if any deduction or withholding for any present or future taxes, levies, imposts or
other governmental charges whatsoever imposed, assessed, levied or collected by or for the account of the jurisdiction in which it is
resident for tax purposes or any political subdivision or taxing authority thereof or therein shall at any time be required by such jurisdiction
(or any such political subdivision or taxing authority) in respect of any amounts to be paid by such successor Person under the Securities,
such Person will (subject to compliance by the Holders of such Securities with any administrative requirements) pay such additional amounts
as may be necessary in order that the net amounts paid to the Holders of the Securities or the Trustee under this Indenture or, as the
case may be, pursuant to the Securities, after such deduction or withholding, shall be not less than the amounts specified in the Securities,
to which such Holders or the Trustee are entitled had no such withholding or deduction been required; provided, however, that the successor
Person shall not be required to make any payment of additional amounts for or on account of (i) any present or future tax, levy,
impost or other governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that the Holder
of the relevant Security (or a fiduciary, settlor, beneficiary, member or shareholder of, or possessor of a power over, such Holder, if
such Holder is an estate, trust, partnership or corporation) is or has been a domiciliary, national or resident of, or is or has been
engaged in a trade or business in, or maintains or has maintained a permanent establishment in, or is or has been physically present in,
such jurisdiction or any political subdivision or taxing authority thereof or therein or otherwise has or has had some connection with
such jurisdiction or any political subdivision or taxing authority thereof or therein other than the holding or ownership of the Security,
or the collection of principal, premium or interest, if any, on, or the enforcement of, the Security, (ii) any present or future
tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that,
where presentation is required, the relevant Security was presented more than thirty days after the date on which such payment became
due or was provided for, whichever is later, (iii) any estate, inheritance, gift, sale, transfer, personal property or similar tax,
levy, impost or other governmental charge, (iv) any present or future tax, levy, impost or other governmental charge which is payable
otherwise than by deduction or withholding from payments on or in respect of the relevant Security, (v) any present or future tax,
levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but for the failure of the
Holder or the beneficial owner of the relevant Security to comply with any certification, identification or other reporting requirements
concerning the Holder’s or the beneficial owner’s nationality, residence, identity or connection with such jurisdiction or
any political subdivision or taxing authority thereof or therein, if compliance is required by treaty or by statute, regulation or administrative
practice of such jurisdiction or of any such political subdivision or taxing authority thereof or therein as a condition to relief or
exemption from such tax, levy, impost or other governmental charge, (vi) any present or future tax, levy, impost or other governmental
charge which the Holder would have been able to avoid by authorizing the paying agent to report information in accordance with the procedure
laid down by the relevant tax authority or by producing, in the form requested by the relevant tax authority, a declaration, claim, certificate,
document or other evidence establishing exemption therefrom, (vii) any present or future tax, levy, impost or other governmental
charge which is required by FATCA, any current or future U.S. Treasury regulations or rulings promulgated thereunder, any IGA, any law,
regulation or other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal
Revenue Service under or with respect to FATCA, (viii) any present or future tax, levy, impost or other governmental charge which
is imposed or withheld because the Holder of the Security is (1) considered a 10% shareholder (within the meaning of Sections 871(h)(3) or
881(c)(3) of the Code) of the issuer of the Security or (2) a controlled foreign corporation related (within the meaning of
Section 864(d)(4) of the Code) to the issuer of the Security, (ix) any present or future tax, levy, impost or other governmental
charge which is imposed because the Holder (1) is a bank purchasing the Security in the ordinary course of its lending business or
(2) is a bank that is neither (A) buying the Security for investment purposes only nor (B) buying the Security for resale
to a third party that either is not a bank or will hold the Security for investment purposes only, (x) any present or future tax,
levy, impost or other governmental charge which is imposed, assessed, levied or collected in respect of a payment under or with respect
to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the sole beneficial owner
of such payment or Security to the extent that the beneficiary or settlor with respect to the fiduciary, member of that partnership or
beneficial owner would not have been entitled to the additional amounts or would not have been subject to such tax, levy, impost or charge
had that beneficiary, settlor, member or beneficial owner been the actual Holder of such Security or (xi) any combination of clauses
(i) through (x) above, and nor shall additional amounts be paid in the event that the obligation
to pay additional amounts is the result of the issuance of definitive Registered Securities to a Holder of a Predecessor Security at such
Holder’s request upon the occurrence of an Event of Default and at the time payment is made definitive Registered Securities have
not been issued in exchange for the entire principal amount of the Predecessor Securities.




 






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(b)          If,
upon any such amalgamation, reconstruction, consolidation or merger of the Guarantor with or into any other Person, or upon any sale
or conveyance of the property of the Guarantor as an entirety or substantially as an entirety to any other Person, any Principal Property
of the Guarantor or of any of its Restricted Subsidiaries or any shares of stock or indebtedness of any such Restricted Subsidiary would
thereupon become subject to any mortgage, pledge or lien which would be prohibited by Section 3.09, the Guarantor, prior to such
amalgamation, reconstruction, consolidation, merger, sale or conveyance, will secure the Securities, equally and ratably with any other
obligations of the Guarantor then entitled thereto, by a direct lien on all such property equally and ratably with all such mortgages,
pledges or liens.


 


(c)          In
case of any such amalgamation, reconstruction, consolidation, merger, sale or conveyance (other than by way of a temporary lease in the
ordinary course of business) and following such an assumption by the successor Person, such successor Person shall succeed to and be
substituted for the Guarantor, with the same effect as if it had been named herein and the Guarantor shall be relieved of all obligations
and covenants under this Indenture and the Guaranty. In case of any such amalgamation, reconstruction, consolidation, merger, sale or
conveyance such changes in phraseology and form (but not in substance) may be made in the Securities thereafter to be issued as may be
appropriate.


 


Section 12.05     Reimbursement
of the Guarantor. If at any time (a) the Issuer has defaulted in making any payment constituting Guaranteed Obligations (a “Defaulted
Payment”), (b) the Guarantor has paid such Defaulted Payment pursuant to Section 12.01 and (c) the Trustee or
the applicable Holder receives all or a portion of the Defaulted Payment from the Issuer, the Trustee or such Holder, as applicable,
hereby agrees to immediately reimburse the Guarantor in an amount equal to all or whatever portion of the Defaulted Payment it has received
from the Issuer.


 






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Section 12.06     Term.
This Guaranty shall terminate and be of no further force and effect upon the earlier of (a) payment in full of the aggregate principal
amount of all Securities then outstanding and all other Guaranteed Obligations under Section 12.01 then due and owing or (b) the
satisfaction and discharge of this Indenture by the Issuer or the election by the Issuer of its legal defeasance or covenant defeasance
options in accordance with the terms of this Indenture; provided that all Guaranteed Obligations incurred to the date of such satisfaction
and discharge have been paid in full. Upon any such occurrence specified in this Section 12.06, the Trustee shall execute upon request
by the Guarantor, any documents required to evidence such release, discharge or termination in respect of the Guaranty. Neither the Issuer
nor the Guarantor shall be required to make a notation on the Securities to reflect the Guaranty or any such release, termination or
discharge.


 


Section 12.07     Amendments
and Waivers. Notwithstanding any other provision of this Indenture to the contrary, no provision of this Guaranty may be amended
or waived, with respect to any or all series of Securities, unless such amendment or waiver is in writing and is signed by the Guarantor.


 


Section 12.08     Form of
Guaranty. The Guaranty to be endorsed on the Securities shall be in substantially the form set forth below:


 


GUARANTY


 


For value
received, AstraZeneca PLC, an English public limited company (the “Guarantor,” which term includes any Person
as a successor Guarantor under the Indenture referred to in the Security upon which this Guaranty is endorsed), hereby fully and unconditionally
guarantees to the Holder of the Security upon which this Guaranty is endorsed and to the Trustee on behalf of each such Holder the due
and punctual payment of the principal of, interest on and any additional amounts payable in respect of such Security and the due and
punctual payment of the sinking fund or analogous payments referred to therein, if any, when and as the same shall become due and payable,
whether on the stated maturity date, by declaration of acceleration, call for redemption or otherwise, according to the terms thereof
and of the Indenture referred to therein. In case of the failure of AstraZeneca Finance LLC, a limited liability company organized
under the laws of the State of Delaware (the “Issuer,” which term includes any successor Person under such Indenture),
to punctually make any such payment of principal, interest or additional amounts or any such sinking fund or analogous payment, the Guarantor
hereby agrees to cause any such payment to be made punctually when and as the same shall become due and payable, whether on the stated
maturity date or by declaration of acceleration, call for redemption or otherwise, and as if such payment were made by the Issuer. The
indebtedness evidenced by this Guaranty ranks equally and pari passu with all other unsecured and unsubordinated indebtedness
of the Guarantor.


 






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The Guarantor
hereby agrees that its obligations hereunder shall be absolute and unconditional, irrespective of, and shall be unaffected by, any invalidity,
irregularity or unenforceability of such Security or such Indenture, any failure to enforce the provisions of such Security or such Indenture,
or any waiver, modification or indulgence granted to the Issuer with respect thereto, by the Holder of such Security or the Trustee or
any other circumstance that may otherwise constitute a legal or equitable discharge of a guarantor. The Guarantor hereby waives
diligence, presentment, demand of payment, filing of claims with a court in the event of a merger or bankruptcy of the Issuer, any right
to require a proceeding first against the Issuer, protest or notice with respect to such Security or the indebtedness evidenced thereby
or with respect to any sinking fund or analogous payment required under such Security and all demands whatsoever, and covenants that
this Guaranty will not be discharged except by payment in full of the principal of, interest on and additional amounts payable in respect
of such Security. This Guaranty is a guarantee of payment and not of collection.


 


The Guarantor
shall be subrogated to all rights of the Holder of such Security and the Trustee against the Issuer in respect of any amounts paid to
such Holder by the Guarantor pursuant to the provisions of this Guaranty; provided, however, that the Guarantor shall not be entitled
to enforce, or to receive any payments arising out of or based upon such right of subrogation until the principal of, interest on and
additional amounts payable in respect of all Securities of the same series issued under such Indenture shall have been paid in full.


 


No reference
herein to such Indenture and no provision of such Indenture shall alter or impair the guarantees of the Guarantor, which are absolute
and unconditional, of the due and punctual payment of the principal of, interest on and additional amounts payable in respect of, and
any sinking fund or analogous payments with respect to, the Security upon which this Guaranty is endorsed. This Guaranty shall not be
valid or obligatory for any purpose until the certificate of authentication of such Security shall have been executed by manual or pdf
or other electronic image scan signature of the Trustee created on an electronic platform (such as DocuSign) or by digital signing (such
as Adobe Sign) by or on behalf of the Trustee under such Indenture. All terms used in this Guaranty that are defined in such Indenture
shall have the meanings assigned to them in such Indenture. This Guaranty shall be governed by and construed in accordance with the laws
of the State of New York.


 


IN WITNESS whereof,
the Guarantor has caused this Guaranty to be duly executed this          day of         , 20    
..


 






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IN WITNESS WHEREOF, the parties
hereto have caused this Indenture to be duly executed as of                ,
2021.


 


	 	ASTRAZENECA FINANCE LLC,
	 	 
	 	as Issuer
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 
	 	 
	 	ASTRAZENECA PLC,
	 	 
	 	as Guarantor
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 
	 	 
	 	THE BANK OF NEW YORK MELLON,
	 	 
	 	as Trustee
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:




 






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