Exhibit 31.1



CHIEF EXECUTIVE OFFICER CERTIFICATION

REQUIRED BY RULES 13A-14 AND 15D-14 UNDER THE
SECURITIES EXCHANGE ACT OF 1934,

AS AMENDED



I,  J. Michael French, certify that:



1.  I have reviewed this quarterly report
on Form 10-Q/A of Marina Biotech, Inc.;



2.  Based on my knowledge, this report
does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made,
in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;



3.  Based on my knowledge, the financial
statements, and other financial information included in this report, fairly present in all material respects the financial condition,
results of operations and cash flows of the registrant as of, and for, the periods presented in this report;



4.  I am responsible for establishing
and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control
over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and I have:



a) designed such disclosure
controls and procedures, or caused such disclosure controls and procedures to be designed under my supervision, to ensure that
material information relating to the registrant, including its consolidated subsidiaries, is made known to me by others within
those entities, particularly during the period in which this report is being prepared;



b) designed such internal
control over financial reporting, or caused such internal control over financial reporting to be designed under my supervision,
to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;



c) evaluated the effectiveness
of the registrant’s disclosure controls and procedures and presented in this report my conclusions about the effectiveness
of the disclosure controls and procedures as of the end of the period covered by this report based on such evaluation;



d) disclosed in this report
any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most
recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant’s internal
control over financial reporting; and



5.  I have disclosed, based on my most
recent evaluation, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or
persons performing the equivalent function):



a) all significant deficiencies
and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to
adversely affect the registrant’s ability to record, process, summarize and report financial information; and



b) any fraud, whether
or not material, that involves management or other employees who have a significant role in the registrant’s internal control
over financial reporting.



|Dated: October 3, 2014 |  | By:    | /s/ J. Michael French                
|---------------------- |  | ------ | -------------------------------------
|                       |  | Name:  | J. Michael French                    
|                       |  | Title: | President and Chief Executive Officer
|                       |  |        | (Principal Executive Officer and     
|                       |  |        | Principal Financial Officer)