##### Table of Contents





UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-Q

QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF

THE SECURITIES EXCHANGE ACT OF 1934

For the Quarter Ended March 31, 2010

Commission File Number 000-13789





MDRNA, INC.

(Exact name of registrant as specified in its charter)



|                                                              |  |                                     
|------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                      |  | 11-2658569                          
|(State or other jurisdiction ofincorporation or organization) |  | (I.R.S. Employer Identification No.)
|                                                              | 
|3830 Monte Villa Parkway, Bothell, WA                         |  | 98021                               
|(Address of principal executive offices)                      |  | (Zip Code)                          

Registrants telephone number, including area code: (425) 908-3600

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes  þ            
No   ̈

Indicate by check mark whether the registrant has submitted
electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter
period that the registrant was required to submit and post such files).

Yes   ̈            
No   ̈

Indicate by check mark whether the registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the
Exchange Act. (Check One):



|                        |  |                                                  |  |                           |  |  
|----------------------- |  | ------------------------------------------------ |  | ------------------------- |  | -
|Large accelerated filer |  |  ̈                                                |  | Accelerated filer         |  |  ̈
|                        |  |                                                  | 
|Non-accelerated filer   |  |  ̈  (Do not check if a smaller reporting company) |  | Smaller reporting company |  | þ

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes   ̈            
No  þ

Indicate the number of shares outstanding of each of the
issuers classes of common stock, as of the latest practicable date:



|             |  |                                 |  |                   
|------------ |  | ------------------------------- |  | ------------------
|Date         |  | Class                           |  | Shares Outstanding
|May 11, 2010 |  | Common stock  $0.006 par value |  | 48,886,483        









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##### Table of Contents

MDRNA, INC. AND SUBSIDIARIES

TABLE OF CONTENTS



|                                                                                                              |  |   
|------------------------------------------------------------------------------------------------------------- |  | --
|PART I  FINANCIAL INFORMATION                                                                                |  |   
|                                                                                                              | 
|ITEM 1  FINANCIAL STATEMENTS (unaudited)                                                                     |  |   
|Condensed Consolidated Balance Sheets as of December 31, 2009 and March 31,
2010                              |  | 3 
|Condensed Consolidated Statements of Operations for the three months ended March 
31, 2009 and March 31, 2010 |  | 4 
|Condensed Consolidated Statement of Stockholders Deficit for the three months ended March 
31, 2010          |  | 5 
|Condensed Consolidated Statements of Cash Flows for the three months ended March 
31, 2009 and March 31, 2010 |  | 6 
|Notes to Condensed Consolidated Financial Statements                                                          |  | 7 
|ITEM 
2  MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS               |  | 17
|ITEM 3  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK                                           |  | 22
|ITEM 4  CONTROLS AND PROCEDURES                                                                              |  | 22
|                                                                                                              | 
|PART II  OTHER INFORMATION                                                                                   |  |   
|                                                                                                              | 
|ITEM 2  UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS                                          |  | 23
|ITEM 6  EXHIBITS                                                                                             |  | 23
|SIGNATURES                                                                                                    |  | 24
|EXHIBIT INDEX                                                                                                 |  | 25

Items 1, 1A, 3, 4 and
5 of PART II have not been included as they are not applicable.



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PART I  FINANCIAL INFORMATION

ITEM 1  FINANCIAL STATEMENTS

MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)



|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------- | -------- | - | ------------- | - | -------- | -
|                                                                                                                                                                                                                                |  | December 31,2009                                |          |   | March 31,2010 |  
|                                                                                                                                                                                                                                |  | (In thousands, except share and
per share data) |         
|ASSETS                                                                                                                                                                                                                          |  |                                                 |          |   |               |   |          |  
|Current assets:                                                                                                                                                                                                                 |  |                                                 |          |   |               |   |          |  
|Cash                                                                                                                                                                                                                            |  | $                                               | 748      |   |               | $ | 2,630    |  
|Restricted cash                                                                                                                                                                                                                 |  |                                                 | 998      |   |               |   | 1,156    |  
|Accounts receivable                                                                                                                                                                                                             |  |                                                 | 211      |   |               |   | 127      |  
|Prepaid expenses and other current assets                                                                                                                                                                                       |  |                                                 | 700      |   |               |   | 426      |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Total current assets                                                                                                                                                                                                            |  |                                                 | 2,657    |   |               |   | 4,339    |  
|Property and equipment, net                                                                                                                                                                                                     |  |                                                 | 4,569    |   |               |   | 4,258    |  
|Other assets                                                                                                                                                                                                                    |  |                                                 | 3        |   |               |   |         |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Total assets                                                                                                                                                                                                                    |  | $                                               | 7,229    |   |               | $ | 8,597    |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|LIABILITIES AND STOCKHOLDERS DEFICIT                                                                                                                                                                                           |  |                                                 |          |   |               |   |          |  
|Current liabilities:                                                                                                                                                                                                            |  |                                                 |          |   |               |   |          |  
|Accounts payable                                                                                                                                                                                                                |  | $                                               | 2,114    |   |               | $ | 2,139    |  
|Accrued payroll and employee benefits                                                                                                                                                                                           |  |                                                 | 913      |   |               |   | 702      |  
|Other accrued liabilities                                                                                                                                                                                                       |  |                                                 | 1,361    |   |               |   | 1,754    |  
|Deferred revenue                                                                                                                                                                                                                |  |                                                 |         |   |               |   | 126      |  
|Accrued restructuring  current portion                                                                                                                                                                                         |  |                                                 | 425      |   |               |   | 588      |  
|Notes payable, net of discount                                                                                                                                                                                                  |  |                                                 | 317      |   |               |   |         |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Total current liabilities                                                                                                                                                                                                       |  |                                                 | 5,130    |   |               |   | 5,309    |  
|Accrued restructuring, net of current portion                                                                                                                                                                                   |  |                                                 | 281      |   |               |   | 144      |  
|Deferred rent and other liabilities                                                                                                                                                                                             |  |                                                 | 1,461    |   |               |   | 1,453    |  
|Fair value liability for price adjustable warrants                                                                                                                                                                              |  |                                                 | 7,243    |   |               |   | 11,214   |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Total liabilities                                                                                                                                                                                                               |  |                                                 | 14,115   |   |               |   | 18,120   |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Commitments and contingencies                                                                                                                                                                                                   |  |                                                 |          |   |               |   |          |  
|Stockholders deficit:                                                                                                                                                                                                          |  |                                                 |          |   |               |   |          |  
|Preferred stock, $.01 par value; 100,000 shares authorized: no shares issued and outstanding                                                                                                                                    |  |                                                 |         |   |               |   |         |  
|Common stock and additional paid-in capital, $0.006 par value; 90,000,000 shares authorized, 40,806,941 shares issued
and outstanding as of December 31, 2009 and 48,881,483 shares issued and outstanding as of March 31, 2010 |  |                                                 | 256,131  |   |               |   | 262,984  |  
|Accumulated deficit                                                                                                                                                                                                             |  |                                                 | (263,017 | ) |               |   | (272,507 | )
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Total stockholders deficit                                                                                                                                                                                                     |  |                                                 | (6,886   | ) |               |   | (9,523   | )
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  
|Total liabilities and stockholders deficit                                                                                                                                                                                     |  | $                                               | 7,229    |   |               | $ | 8,597    |  
|                                                                                                                                                                                                                                |  |                                                 |          |   |               |   |          |  

See notes to condensed consolidated financial statements



3



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MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited)



|                                                                         |  |                                       |        |   |      |   |        |  
|------------------------------------------------------------------------ |  | ------------------------------------- | ------ | - | ---- | - | ------ | -
|                                                                         |  | Three Months EndedMarch 31,           |       
|                                                                         |  | 2009                                  |        |   | 2010 |  
|                                                                         |  | (In thousands, except per share data) |       
|License and other revenue                                                |  | $                                     | 14,151 |   |      | $ | 184    |  
|                                                                         |  |                                       |        |   |      |   |        |  
|Operating expenses:                                                      |  |                                       |        |   |      |   |        |  
|Research and development                                                 |  |                                       | 4,116  |   |      |   | 3,599  |  
|Selling, general and administrative                                      |  |                                       | 2,107  |   |      |   | 2,559  |  
|Restructuring                                                            |  |                                       | 133    |   |      |   | 26     |  
|                                                                         |  |                                       |        |   |      |   |        |  
|Total operating expenses                                                 |  |                                       | 6,356  |   |      |   | 6,184  |  
|                                                                         |  |                                       |        |   |      |   |        |  
|Income (loss) from operations                                            |  |                                       | 7,795  |   |      |   | (6,000 | )
|                                                                         |  |                                       |        |   |      |   |        |  
|Other income (expense):                                                  |  |                                       |        |   |      |   |        |  
|Interest income                                                          |  |                                       | 2      |   |      |   |       |  
|Interest and other expense                                               |  |                                       | (143   | ) |      |   | (780   | )
|Change in fair value liability for price adjustable warrants             |  |                                       | (1,027 | ) |      |   | (2,710 | )
|Gain on settlement of liabilities, net                                   |  |                                       | 654    |   |      |   |       |  
|                                                                         |  |                                       |        |   |      |   |        |  
|Total other income (expense)                                             |  |                                       | (514   | ) |      |   | (3,490 | )
|                                                                         |  |                                       |        |   |      |   |        |  
|Net income (loss)                                                        |  | $                                     | 7,281  |   |      | $ | (9,490 | )
|                                                                         |  |                                       |        |   |      |   |        |  
|Net income (loss) per common share:                                      |  |                                       |        |   |      |   |        |  
|Basic and diluted                                                        |  | $                                     | 0.23   |   |      | $ | (0.20  | )
|                                                                         |  |                                       |        |   |      |   |        |  
|Shares used in computing net income (loss) per share  basic and diluted |  |                                       | 32,243 |   |      |   | 47,328 |  
|                                                                         |  |                                       |        |   |      |   |        |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS DEFICIT

For the Three Months Ended March 31, 2010

(Unaudited)



|                                                                                                             |  |                                            |  |                    |         |  |                           |          |   |  |   |        |  
|------------------------------------------------------------------------------------------------------------ |  | ------------------------------------------ |  | ------------------ | ------- |  | ------------------------- | -------- | - |  | - | ------ | -
|                                                                                                             |  | Common Stock and AdditionalPaid-In Capital |  | AccumulatedDeficit |         |  | TotalStockholdersDeficit |         
|                                                                                                             |  | Shares                                     |  | Amount             |         | 
|                                                                                                             |  | (In thousands, except share data)          | 
|Balance December 31, 2009                                                                                    |  | 40,806,941                                 |  | $                  | 256,131 |  | $                         | (263,017 | ) |  | $ | (6,886 | )
|Proceeds from the issuance of common shares, net                                                             |  | 5,385,557                                  |  |                    | 804     |  |                           |         |   |  |   | 804    |  
|Proceeds from the exercise of warrants                                                                       |  | 2,515,000                                  |  |                    | 2,565   |  |                           |         |   |  |   | 2,565  |  
|Reclassification of fair value liability for price adjustable warrants exercised                             |  |                                           |  |                    | 2,878   |  |                           |         |   |  |   | 2,878  |  
|Proceeds from the exercise of options and employee stock purchase plan purchases                             |  | 123,985                                    |  |                    | 68      |  |                           |         |   |  |   | 68     |  
|Shares issued in connection with settlement of liabilities                                                   |  | 50,000                                     |  |                    | 55      |  |                           |         |   |  |   | 55     |  
|Compensation related to restricted stock, stock options and employee stock purchase plan, net of forfeitures |  |                                           |  |                    | 483     |  |                           |         |   |  |   | 483    |  
|Net loss                                                                                                     |  |                                           |  |                    |        |  |                           | (9,490   | ) |  |   | (9,490 | )
|                                                                                                             |  |                                            |  |                    |         |  |                           |          |   |  |   |        |  
|Balance March 31, 2010                                                                                       |  | 48,881,483                                 |  | $                  | 262,984 |  | $                         | (272,507 | ) |  | $ | (9,523 | )
|                                                                                                             |  |                                            |  |                    |         |  |                           |          |   |  |   |        |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)



|                                                                                                            |  |                             |        |   |      |   |        |  
|----------------------------------------------------------------------------------------------------------- |  | --------------------------- | ------ | - | ---- | - | ------ | -
|                                                                                                            |  | Three Months EndedMarch 31, |       
|                                                                                                            |  | 2009                        |        |   | 2010 |  
|                                                                                                            |  | (In thousands)              |       
|Operating activities:                                                                                       |  |                             |        |   |      |   |        |  
|Net income (loss)                                                                                           |  | $                           | 7,281  |   |      | $ | (9,490 | )
|Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:          |  |                             |        |   |      |   |        |  
|Non-cash compensation (benefit) related to restricted stock, stock options and employee stock purchase plan |  |                             | (4     | ) |      |   | 483    |  
|Depreciation and amortization                                                                               |  |                             | 723    |   |      |   | 437    |  
|Non-cash amortization of discount on notes payable and debt issuance costs                                  |  |                             |       |   |      |   | 770    |  
|Accretion of restructuring liability                                                                        |  |                             | 68     |   |      |   | 26     |  
|Gain on disposition of property and equipment                                                               |  |                             | (104   | ) |      |   |       |  
|Net gain on settlement of liabilities                                                                       |  |                             | (654   | ) |      |   |       |  
|Non-cash change in fair value of price adjustable warrants                                                  |  |                             | 1,027  |   |      |   | 2,710  |  
|Changes in assets and liabilities:                                                                          |  |                             |        |   |      |   |        |  
|Accounts receivable                                                                                         |  |                             | 19     |   |      |   | 84     |  
|Inventories                                                                                                 |  |                             | 6      |   |      |   |       |  
|Prepaid expenses and other assets                                                                           |  |                             | 260    |   |      |   | 190    |  
|Accounts payable                                                                                            |  |                             | (324   | ) |      |   | 80     |  
|Deferred revenue                                                                                            |  |                             | (535   | ) |      |   | 126    |  
|Accrued expenses and deferred rent and other liabilities                                                    |  |                             | (448   | ) |      |   | 174    |  
|Accrued restructuring                                                                                       |  |                             | (134   | ) |      |   |       |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Net cash provided by (used in) operating activities                                                         |  |                             | 7,181  |   |      |   | (4,410 | )
|                                                                                                            |  |                             |        |   |      |   |        |  
|Investing activities:                                                                                       |  |                             |        |   |      |   |        |  
|Change in restricted cash                                                                                   |  |                             | 113    |   |      |   | (158   | )
|Purchases of property and equipment                                                                         |  |                             |       |   |      |   | (126   | )
|Proceeds from sales of property and equipment                                                               |  |                             | 878    |   |      |   |       |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Net cash provided by (used in) investing activities                                                         |  |                             | 991    |   |      |   | (284   | )
|                                                                                                            |  |                             |        |   |      |   |        |  
|Financing activities:                                                                                       |  |                             |        |   |      |   |        |  
|Proceeds from sales of common shares and warrants, net                                                      |  |                             |       |   |      |   | 4,943  |  
|Proceeds from exercise of stock options, warrants and employee stock purchase plan purchases                |  |                             |       |   |      |   | 2,633  |  
|Payments on note payable                                                                                    |  |                             | (3,724 | ) |      |   | (1,000 | )
|                                                                                                            |  |                             |        |   |      |   |        |  
|Net cash provided by (used in) financing activities                                                         |  |                             | (3,724 | ) |      |   | 6,576  |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Net increase in cash                                                                                        |  |                             | 4,448  |   |      |   | 1,882  |  
|Cash  beginning of year                                                                                    |  |                             | 1,084  |   |      |   | 748    |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Cash  end of period                                                                                        |  | $                           | 5,532  |   |      | $ | 2,630  |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Non-cash financing activities:                                                                              |  |                             |        |   |      |   |        |  
|Note payable issued upon cancellation of capital lease obligations                                          |  | $                           | 5,547  |   |      | $ |       |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Issuance of common stock to settle liabilities                                                              |  | $                           | 982    |   |      | $ | 55     |  
|                                                                                                            |  |                             |        |   |      |   |        |  
|Supplemental disclosure:                                                                                    |  |                             |        |   |      |   |        |  
|Cash paid for interest                                                                                      |  | $                           | 70     |   |      | $ | 10     |  
|                                                                                                            |  |                             |        |   |      |   |        |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

For the three months ended March 31, 2010 and 2009 (Unaudited)

Note 1  Business, Going Concern and Summary of Significant Accounting Policies

Business

We are a biotechnology company focused on the discovery, development and commercialization of pharmaceuticals based on RNA interference
(RNAi). Our goal is to be the leader in RNAi therapeutics and improve human health through the development of RNAi-based compounds that provide superior therapeutic options for patients. Our team of approximately 30 scientists brings
expertise in the discovery, evaluation and optimization of small interfering RNAs (siRNAs) as well as siRNA delivery. We have the requisite experience in the areas of RNAi, molecular and cellular biology, amino acid, oligonucleotide and
peptide chemistry, pharmacology and bioinformatics necessary to discover and develop tailored RNAi-based compounds designed to elicit specific therapeutic effects on a target-by-target basis. Our infrastructure provides for pre-clinical scale
manufacturing of both siRNAs and delivery materials, the comprehensive analysis and optimization of these compounds both individually and as drug candidates, and the filing of Investigational New Drug Applications. In addition to our own, internally
developed technologies, we strategically in-license and further develop RNAi- and delivery-related technologies, forming a single integrated drug discovery platform. In order to protect our innovations, which encompass a broad platform of both siRNA
and delivery technologies, and the eventual drug products that emerge from that platform, we will aggressively continue to build upon our extensive and enabling intellectual property (IP) estate.

Our business strategy is two-fold. First, we strive to establish collaborations and strategic partnerships with
pharmaceutical and biotechnology companies in the area of RNAi-based therapeutics to: (1) generate revenue and non-dilutive financing; (2) gain access to technical resources; and (3) validate our drug discovery platform. Secondly, we
expect to advance our own pipeline of RNAi-based therapeutics as a foundation upon which to improve all aspects of our drug discovery platform and to have the opportunity to commercialize drug therapies. Our pipeline is focused on bladder and liver
cancer. With respect to collaborations and strategic partnerships, we are currently focused on our UsiRNA constructs, as well as our
DiLA2and peptide delivery technologies. Collaborations
are expected to range from feasibility studies to the development of therapeutic candidates. We expect to collaborate with partners who can take a drug candidate through to product commercialization by utilizing their late stage clinical
development, regulatory, marketing and sales capabilities. We expect to structure our collaborative agreements to receive upfront non-refundable payments, research and development funding, milestone payments and royalties on commercial sales of
products.

On March 31, 2010, we entered into an Agreement and Plan of Merger (the Cequent Merger Agreement)
with Cequent Pharmaceuticals, a privately-held Delaware corporation, which is developing novel products to deliver RNAi-based therapeutics. The combined company will have multiple proprietary RNAi drug discovery platforms with the capability to
deliver RNAi-based therapeutics via systemic, local and oral administration. In addition, the acquisition expands our oncology pipeline with a product for Familial Adenomatous Polyposis (FAP)  a genetic disorder that is a precursor to colon
cancer  that will soon begin Phase 1 clinical testing under an Investigational New Drug application (IND) filed with the U.S. Food and Drug Administration (FDA). Consummation of the merger is subject to the satisfaction or waiver of customary
closing conditions, including obtaining the requisite approval of our stockholders. Approval of the merger by Cequents stockholders was obtained on April 2, 2010. As a result of the proposed merger, Cequent will become our wholly-owned
subsidiary.

We believe we have established ourselves as a leading RNAi-based therapeutics company by leveraging our broad and
proven expertise in RNAi science and delivery into an industry-leading RNAi drug discovery platform, which is protected by a strong IP position and validated through licensing agreements with two large international pharmaceutical companies.

Going Concern

The accompanying condensed consolidated financial statements have been prepared on the basis that we will continue as a going concern,
which contemplates realization of assets and the satisfaction of liabilities in the normal course of business. As of March 31, 2010, we had an accumulated deficit of approximately $272.5 million and expect to incur losses in the future as we
continue our research and development (R&D) activities. In 2008, we suspended all research and clinical development of our intranasal programs and, as of September 30, 2008, incurred a restructuring charge to exit a facility
which was used primarily for our intranasal activities. As of September 30, 2008, our accumulated deficit, which was primarily related to clinical development of our intranasal programs, was approximately $241.8 million. Our operating expenses,
primarily R&D in connection with the further development of our RNAi programs, will consume the majority of our cash resources and will require additional funding. We have funded our losses primarily through the sale of common stock and warrants
in the public markets and private placements, revenue provided by our collaboration partners, and, to a lesser extent, equipment financing facilities and loans.

At March 31, 2010, we had a working capital deficit (current assets less current liabilities) of approximately $1.0 million and
approximately $3.8 million in cash, including approximately $1.2 million in restricted cash. On March 31, 2010, in connection with the execution of the Cequent Merger Agreement, we entered into a Loan Agreement with Cequent pursuant to which,
among other



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



things, Cequent shall extend to us one or more loans in the aggregate principal amount of up to $3.0 million to fund our operations prior to the proposed merger. We believe that our current
resources, including the loans from Cequent pursuant to the Loan Agreement, will be sufficient to fund our planned operations into the third quarter of 2010.

We plan to continue to work with large pharmaceutical companies regarding research and development collaboration agreements or
investments, and to pursue public and private sources of financing to raise cash. However, there can be no assurance that we will be successful in such endeavors. The market value and the volatility of our stock price, as well as general market
conditions, could make it difficult for us to complete a financing transaction on favorable terms, or at all. Any financing we obtain may further dilute the ownership interest of our current stockholders. If we are unable to obtain additional
capital when required, we could modify, delay or abandon some or all of our programs. These factors, among others, raise substantial doubt about our ability to continue as a going concern. The accompanying condensed consolidated financial statements
do not include any adjustments that may result from the outcome of this uncertainty. The Report of Independent Registered Public Accounting Firm included in our Annual Report on Form 10-K for the year ended December 31, 2009 states that these
conditions, among others, raise substantial doubt about our ability to continue as a going concern.

Basis of
Preparation and Summary of Significant Accounting Policies

Basis of Preparation The accompanying
unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial information and in accordance with the instructions to Form
10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and note disclosures required by U.S. generally accepted accounting principles for complete financial statements. The accompanying unaudited financial
information should be read in conjunction with the audited consolidated financial statements, including the notes thereto, as of and for the year ended December 31, 2009, included in our 2009 Annual Report on Form 10-K filed with the Securities
and Exchange Commission (the SEC). The information furnished in this report reflects all adjustments (consisting of normal recurring adjustments), which are, in the opinion of management, necessary for a fair presentation of our
financial position, results of operations and cash flows for each period presented. The results of operations for the interim period ended March 31, 2010 are not necessarily indicative of the results for the year ending December 31, 2010
or for any future period.

Use of Estimates The preparation of financial statements in conformity with
accounting principles generally accepted in the United States of America requires our management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at
the date of the financial statements, and reported amounts of revenues and expenses during the reporting periods. Estimates having relatively higher significance include revenue recognition, research and development costs, stock-based compensation,
valuation of our warrants, impairment of long-lived assets, estimated accrued restructuring charges and income taxes. Actual results could differ from those estimates.

Restricted Cash  Amounts pledged as collateral underlying letters of credit for facility lease deposits are classified
as restricted cash. Changes in restricted cash have been presented as investing activities in the consolidated statements of cash flows.

Accrued Restructuring We ceased using our facility at 3450 Monte Villa Parkway, Bothell, Washington (3450 Monte
Villa) in 2008. We recorded an accrued liability for remaining lease termination costs at fair value, based on the remaining payments due under the lease and other costs, reduced by sublease rental income that could be reasonably obtained from
the property, and discounted using a credit-adjusted risk-free interest rate. We based our estimated future payments on current rental rates available in the Bothell real estate market, and our evaluation of the ability to sublease the facility.
Accrued restructuring, and in particular those charges associated with exiting a facility, are based upon managements estimates of future payments. These estimates significantly impact the accrual and actual results may differ from our
estimates. We review these estimates at least quarterly and when there are changes in facts or circumstances, and adjust our accrual if necessary. For a further discussion of our restructuring charges, see Note 3  Accrued Restructuring.

Fair Value of Financial Instruments  We consider the fair value of cash, restricted cash, accounts
receivable, accounts payable and accrued liabilities to not be materially different from their carrying value. These financial instruments have short-term maturities. The carrying value of notes payable approximated fair value as interest rates
represented current market rates.

We follow authoritative guidance with respect to fair value reporting issued by the
Financial Accounting Standards Board (FASB), for financial assets and liabilities, which defines fair value, provides guidance for measuring fair value and requires certain disclosures. The guidance establishes a fair value hierarchy
that prioritizes the inputs to valuation techniques used to measure fair value into three broad levels. The following is a brief description of those three levels:

Level 1: Observable inputs such as quoted prices (unadjusted) in active markets for identical assets or liabilities.



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



Level 2: Inputs other than quoted prices that are observable for the asset or
liability, either directly or indirectly. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active.

Level 3: Unobservable inputs in which little or no market data exists, therefore developed using estimates and assumptions developed
by us, which reflect those that a market participant would use.

All of our financial assets subject to fair value measurement
are valued determined by Level 1 inputs. We currently measure and report at fair value the liability for price adjustable warrants using the Black-Scholes-Merton valuation model, a Level 3 input. The following table summarizes our financial
liabilities measured at fair value on a recurring basis as of March 31, 2010 (in thousands):



|                                                   |  |                         |        |                                                           |   |                                          |   |                                      |   |       
|-------------------------------------------------- |  | ----------------------- | ------ | --------------------------------------------------------- | - | ---------------------------------------- | - | ------------------------------------ | - | ------
|                                                   |  | Balance atMarch 31,2010 |        | Level 1Quoted prices inactive markets foridentical assets |   | Level 2Significant otherobservableinputs |   | Level 3Significantunobservableinputs
|Liabilities:                                       |  |                         |        |                                                           |   |                                          |   |                                      |   |       
|Fair value liability for price adjustable warrants |  | $                       | 11,214 |                                                           |  |                                          |  |                                      | $ | 11,214
|                                                   |  |                         |        |                                                           |   |                                          |   |                                      |   |       
|Total financial liabilities at fair value          |  | $                       | 11,214 |                                                           |  |                                          |  |                                      | $ | 11,214
|                                                   |  |                         |        |                                                           |   |                                          |   |                                      |   |       

The following presents activity of the fair value
liability of price adjustable warrants determined by Level 3 inputs (in thousands):



|                                                         |  |   |        |  
|-------------------------------------------------------- |  | - | ------ | -
|Balance at December 31, 2009                             |  | $ | 7,243  |  
|Reclassification of fair value of warrants exercised     |  |   | (2,878 | )
|Fair value of warrants issued                            |  |   | 4,139  |  
|Change in fair value included in statement of operations |  |   | 2,710  |  
|                                                         |  |   |        |  
|Balance at March 31, 2010                                |  | $ | 11,214 |  
|                                                         |  |   |        |  

Net Income (Loss) Per Common Share  Basic and diluted net income (loss) per common share is
computed by dividing the net income (loss) by the weighted average number of common shares outstanding during the period. Diluted net income (loss) per share excludes the effect of common stock equivalents (stock options, unvested restricted stock
and warrants) since such inclusion in the computation would be anti-dilutive. The following numbers of shares have been excluded from the net income (loss) per share computations:



|                          |  |                                  |  |                                 
|------------------------- |  | -------------------------------- |  | --------------------------------
|                          |  | Three months endedMarch 31, 2009 |  | Three months endedMarch 31, 2010
|Stock options outstanding |  | 6,084,231                        |  | 8,334,731                       
|Unvested restricted stock |  | 79,060                           |  | 16,921                          
|Warrants                  |  | 4,819,791                        |  | 12,533,472                      
|                          |  |                                  |  |                                 
|Total                     |  | 10,983,082                       |  | 20,885,124                      
|                          |  |                                  |  |                                 

Reclassifications Certain
reclassifications have been made to prior years financial statements to conform with current year presentations. Previously, we presented sales and marketing expenses separately from general and administrative expenses. These expenses were
combined into selling, general and administrative expenses in 2010. In addition, product revenue and government grant revenue, which were previously presented separately, were combined with license and other revenue in 2010. The reclassifications
had no effect on stockholders deficit, net loss, or net decrease in cash.

Recent Accounting Pronouncements In April 2010, the Financial Accounting Standards Board issued guidance on applying the Milestone Method of Revenue Recognition to milestone payments for achieving specified performance measures when those payments are related to
uncertain future events. Under the guidance, entities can make an accounting policy election to recognize arrangement consideration received for achieving specified performance measures during the period in which the milestones are achieved,
provided certain criteria are met. This guidance will be applicable to us and is effective on a prospective basis for milestones achieved in fiscal years, and interim periods within those years, beginning on or after June 15, 2010. Early
adoption is permitted. We do not anticipate that the adoption of this accounting guidance will have a material effect on our consolidated financial statements.



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



Note 2  Concentration of Credit Risk and Significant Customers

We operate in an industry that is highly regulated, competitive and rapidly changing and involves numerous risks and uncertainties.
Significant technological and/or regulatory changes, the emergence of competitive products and other factors could negatively impact our consolidated financial position or results of operations.

We have been dependent on our collaborative agreements with a limited number of third parties for a substantial portion of our revenue,
and our discovery and development activities may be delayed or reduced if we do not maintain successful collaborative arrangements. We had revenue from customers, as a percentage of total revenue, as follows:



|                       |  |                              |   |  |      |  
|---------------------- |  | ---------------------------- | - |  | ---- | -
|                       |  | Three Months Ended March 31, |  
|                       |  | 2009                         |   |  | 2010 |  
|Par Pharmaceuticals    |  |                             |   |  | 49   | %
|Undisclosed Partner #1 |  |                             |   |  | 20   | %
|Undisclosed Partner #2 |  |                             |   |  | 16   | %
|Novartis               |  | 52                           | % |  |     |  
|Roche                  |  | 35                           | % |  |     |  
|Amylin                 |  | 7                            | % |  |     |  
|QOL Medical, LLC       |  | 6                            | % |  |     |  
|Other                  |  |                             |   |  | 15   | %
|                       |  |                              |   |  |      |  
|Total                  |  | 100                          | % |  | 100  | %
|                       |  |                              |   |  |      |  

Note 3  Accrued Restructuring

Since late 2007, we have restructured our operations to focus on our RNAi programs. As part of the restructuring, we have reduced our
workforce and have taken other steps to reduce our cash expenditures. During 2008, we exited our facility at 3450 Monte Villa and recorded a restructuring liability, representing estimated future payments due under the lease and other costs and
discounted using a credit-adjusted risk-free interest rate of 15%. In 2009, we entered into an amendment of our lease for the exited facility, which reduced our lease obligations by approximately $1.9 million, and we issued 1,500,000 shares of
our common stock to the landlord. In addition, in 2009, the landlord leased approximately 37% of the exited facility, and in connection therewith, we entered into an amendment to our lease agreement which, among other things, terminated the lease
with respect to this portion of the premises.

Accrued restructuring, and in particular those charges associated with exiting
a facility, are subject to managements assumptions and estimates, as well as changes in facts and circumstances. In addition to the interest rate used, the assumptions as to estimated future payments significantly impact the accrual and actual
results may differ from our estimates. As of March 31, 2010, the balance of our accrued restructuring liability is approximately $0.7 million. In the three months ended March 31, 2009 and 2010 we recorded restructuring charges representing
accretion of the accrued restructuring liability and other facility-related costs in the amounts of $133,000 and $26,000, respectively, and we expect to incur approximately $0.3 million in accretion expense through the expiration of this lease in
2016.

Note 4  Notes Payable

In January 2009, we entered into a Loan and Security Agreement (the Loan Agreement) with General Electric Capital Corporation
(GECC) pursuant to which GECC converted the balance due under capital lease obligations, along with a lease termination fee and amounts payable for property taxes, to a promissory note in the amount of approximately $5.5 million at an
interest rate of 12.3% per year. As a result of the capital lease termination and issuance of the note payable, we recorded a lease termination fee of approximately $0.2 million in the three months ended March 31, 2009, which was presented
as a component of gain on settlement of liabilities, net. The loan was paid in full in June 2009 and the Loan Agreement terminated.

In December 2009 we entered into a Note and Warrant Purchase Agreement (the Note Agreement), pursuant to which we received $1
million cash and issued 12% secured promissory notes due February 1, 2010 in the aggregate principal amount of $1.0 million ( the Notes) and warrants to purchase up to 1,075,269 shares of our common stock. The warrants have an
exercise price of $1.00 per share, which is subject to downward price adjustment, and are exercisable for five years. The Note Agreement contained certain customary representations, warranties and covenants, including that we would not declare or
pay dividends. The Notes were collateralized by substantially all of our assets. In January 2010, we received net proceeds of approximately $4.9 million in a registered direct offering of 5,385,557 shares of common stock and 3,500,612 warrants. In
January 2010, we paid the principal amount of the notes and accrued interest in full, the Note Agreement terminated, and the collateral was released.

In connection with the Note Agreement, we recorded debt issuance costs of approximately $0.1 million which were amortized as interest and
other expense over the term of the notes. In addition, we recorded a discount on notes payable of approximately $0.9



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



million which represents the fair value of the warrants issued in connection with the notes payable, as determined utilizing the Black-Scholes-Merton valuation model with assumptions of expected
life of five years, volatility rate of 117%, risk-free interest rate of 2.5% and dividend rate of nil. The discount on notes payable was reported net of related notes payable and amortized as interest expense over the term of the notes. The
estimated fair value of the warrants was recorded as an increase in fair value liability for price adjustable warrants, which is revalued each balance sheet date. The following table reflects the activity in Notes payable and related discount for
the three months ended March 31, 2010 (in thousands):



|                                             |  |              |        |   |          |   |      |                               |  |   |        |  
|-------------------------------------------- |  | ------------ | ------ | - | -------- | - | ---- | ----------------------------- |  | - | ------ | -
|                                             |  | NotesPayable |        |   | Discount |   |      | Notes Payable, net ofDiscount | 
|Balance at December 31, 2009                 |  | $            | 1,000  |   |          | $ | (683 | )                             |  | $ | 317    |  
|Amortization of discount to interest expense |  |              |       |   |          |   | 683  |                               |  |   | 683    |  
|Payments                                     |  |              | (1,000 | ) |          |   |     |                               |  |   | (1,000 | )
|                                             |  |              |        |   |          |   |      |                               |  |   |        |  
|Balance at March 31, 2010                    |  | $            |       |   |          | $ |     |                               |  | $ |       |  
|                                             |  |              |        |   |          |   |      |                               |  |   |        |  

On March 31, 2010, in connection with the execution of the Cequent Merger Agreement, we entered into a
Loan Agreement with Cequent pursuant to which, among other things, Cequent shall extend to us one or more loans in the aggregate principal amount of up to $3.0 million to fund our operations prior to the proposed merger. On April 30, 2010,
Cequent loaned us $1.0 million under the Loan Agreement. The loans are evidenced by a secured promissory note, issued by us to Cequent, which bears interest absent an event of default, at a rate of ten percent per annum. We shall repay the principal
and interest of the loans in three equal consecutive monthly installments, commencing on August 15, 2010 and continuing on the 15th day of each month thereafter through and including October 15, 2010. Notwithstanding the foregoing, if the
proposed merger is consummated prior to August 15, 2010, then, on the closing date of the merger, we shall not owe to any third party any obligations with respect to the loans, including, without limitation, the then outstanding principal
balance of the loans and any interest then accrued but unpaid thereon. We may prepay the loan in whole or in part without premium or penalty.

We agreed in the Loan Agreement to issue to Cequent on or about the date of each loan a warrant to purchase shares of common stock, with
each such warrant to be exercisable for a number of shares of common stock equal to sixty-five percent (65%) of the principal amount of the loan being made on such date divided by $1.1496. The loan warrants are only exercisable, for a five year
term, if the merger is not consummated, other than by reason of Cequents material breach of the Cequent Merger Agreement, and we engage in a transaction that is similar to the proposed merger, prior to the one year anniversary of the
termination of the Cequent Merger Agreement. Our obligations and the rights of Cequent under each loan warrant will be effective upon the issuance of such loan warrants and will survive payment of the loans and our other obligations to Cequent under
the Loan Agreement and the documents related thereto, and the termination of the Loan Agreement. In April 2010, in connection with the issuance of notes payable to Cequent, we issued a warrant to purchase 565,414 shares of common stock at $1.1496
per share. The warrant provides that the exercise price of the warrant will be reduced in the event of subsequent financings at an effective price per share less than the exercise price of the warrants. The issuance of this warrant was not a
dilutive issuance.

Note 5  Stockholders Equity

Preferred Stock  Our board of directors has the authority, without action by the stockholders, to designate and issue up
to 100,000 shares of preferred stock in one or more series and to designate the rights, preferences and privileges of each series, any or all of which may be greater than the rights of our common stock. We have designated 90,000 shares as
Series A Junior Participating Preferred, of which no shares are outstanding.

Stockholder Rights Plan In 2000,
our board of directors adopted a stockholder rights plan and declared a dividend of one preferred stock purchase right for each outstanding share of common stock. Each right entitles the holder, once the right becomes exercisable, to purchase from
us one one-thousandth of a share of our Series A Junior Participating Preferred Stock, par value $.01 per share. We issued these rights in March 2000 to each stockholder of record on such date, and these rights attach to shares of common stock
subsequently issued. The rights will cause substantial dilution to a person or group that attempts to acquire us on terms not approved by our board of directors and could, therefore, have the effect of delaying or preventing someone from taking
control of us, even if a change of control were in the best interest of our stockholders.

Holders of our preferred share
purchase rights are generally entitled to purchase from us one one-thousandth of a share of Series A preferred stock at a price of $50.00, subject to adjustment as provided in the Stockholder Rights Agreement. These preferred share purchase rights
will generally be exercisable only if a person or group becomes the beneficial owner of 15 percent or more of our outstanding common stock or announces a tender offer for 15 percent or more of our outstanding common stock. Each holder of a preferred
share purchase right, excluding an acquiring entity or any of its affiliates, will have the right to receive, upon exercise, shares of our common stock, or shares of stock of the acquiring entity, having a market value equal to two times the
purchase price paid for



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



one one-thousandth of a share of Series A preferred stock. In March 2010 we amended the Stockholder Rights Agreement to extend the expiration date of the preferred share purchase rights from
March 17, 2010 to March 17, 2013, subject to shareholder approval. Initially, 10,000 Series A Junior Participating Preferred shares were authorized, which has been increased to 90,000 shares.

Common Stock  Holders of our common stock are entitled to one vote for each share held of record on all matters
submitted to a vote of the holders of our common stock. Subject to the rights of the holders of any class of our capital stock having any preference or priority over our common stock, the holders of shares of our common stock are entitled to receive
dividends that are declared by our board of directors out of legally available funds. In the event of our liquidation, dissolution or winding-up, the holders of common stock are entitled to share ratably in our net assets remaining after payment of
liabilities, subject to prior rights of preferred stock, if any, then outstanding. Our common stock has no preemptive rights, conversion rights, redemption rights or sinking fund provisions, and there are no dividends in arrears or default. All
shares of our common stock have equal distribution, liquidation and voting rights, and have no preferences or exchange rights.

Pursuant to a universal shelf registration statement filed with the SEC and declared effective by the SEC in 2008, we could issue up to
$50.0 million of our common stock, preferred stock, debt securities, warrants to purchase any of the foregoing securities and units comprised of any of the foregoing securities. We accessed our universal shelf registration statement in connection
with our April 2008, June 2009 and January 2010 offerings of common stock and warrants and our December 2009 issuance of warrants.

In January 2010, we received net proceeds of approximately $4.9 million from an offering of units comprised of 5,385,577 shares of common
stock together with warrants to purchase up to 3,500,612 shares of our common stock at a purchase price of $1.02125 per unit.

Warrants In connection with offerings of our common stock and notes payable, we have issued warrants to purchase shares of
our common stock. In April 2008, we issued warrants to purchase 4,590,277 shares exercisable for seven years with an exercise price of $2.376 per share, warrants to purchase 1,377,084 shares exercisable for a 90 day period with an exercise price of
$2.17 per share (which expired in January 2009) and warrants to purchase 229,514 shares exercisable for five years with an exercise price of $2.376 per share. In June 2009, we issued 5,250,000 warrants exercisable for the five-year period beginning
in December 2009 with an exercise price of $2.38 per share. In December 2009, we issued warrants to purchase 1,075,269 shares exercisable for five years with an exercise price of $1.02 per share. In January 2010, we issued warrants to purchase
3,500,612 shares of common stock exercisable for five years with an exercise price of $1.00 per share.

The warrants provide
that the exercise price of the warrant will be reduced in the event of subsequent financings at an effective price per share less than the exercise price of the warrants, subject to certain exceptions and limitations. The April 2008 warrants also
require a corresponding adjustment of the number of shares of common stock that may be acquired such that the total consideration payable remains unchanged upon full exercise regardless of a downward adjustment in the exercise price. In connection
with our June 2009 offering, we agreed to seek shareholder approval, at our next annual shareholders meeting, to amend the April 2008 warrant agreements to allow the warrants to be repriced below the $2.17 price floor upon dilutive issuances
subsequent to such shareholder approval. The June 2009 offering was specifically excluded by the April 2008 warrant holders from triggering any potential anti-dilution provisions of the April 2008 warrants.

In December 2009, in connection with the issuance of notes payable, we issued warrants to purchase 1,075,269 shares of common stock. The
issuance of these warrants was a dilutive issuance and in accordance with the terms of the warrant agreements, the April 2008 warrants were repriced to $2.17 per share and warrants to purchase an additional 452,800 shares at $2.17 per share were
issued, and the June 2009 warrants were repriced to $1.02 per share. The June 2009 warrants are subject to additional repricings upon future dilutive issuances. The December 2009 warrants are subject to additional repricings upon future dilutive
issuances until December 31, 2010.

In January 2010, we issued warrants to purchase 3,500,612 shares of common stock at
$1.00 per share. The warrants are exercisable until January 19, 2015 and the warrants provide that the exercise price of the warrant will be reduced in the event of subsequent financings at an effective price per share less than the exercise
price of the warrants, limited to a price floor of $0.94 per share. We also agreed to seek shareholder approval, at our next annual shareholders meeting, to remove the price floor of $0.94 per share. In addition, as a result of the January
2010 issuance of the warrants at $1.00 per share, 3,825,269 warrants previously outstanding that were issued in June 2009 and December 2009 were repriced to $1.00 per share.

In the three months ended March 31, 2010, warrants to purchase 2,515,000 shares were exercised, pursuant to which we received cash
proceeds of approximately $2.6 million and issued 2,515,000 shares of our common stock.

The following summarizes warrant
activity during the three months ended March 31, 2010.



|                                        |  |                |   |  |                                |     
|--------------------------------------- |  | -------------- | - |  | ------------------------------ | ----
|                                        |  | Warrant Shares |   |  | Weighted AverageExercise Price
|Warrants outstanding, December 31, 2009 |  | 11,547,860     |   |  | $                              | 1.54
|Warrants issued                         |  | 3,500,612      |   |  |                                | 1.00
|Warrants exercised                      |  | (2,515,000     | ) |  |                                | 1.02
|                                        |  |                |   |  |                                |     
|Warrants outstanding, March 31, 2010    |  | 12,533,472     |   |  | $                              | 1.49
|                                        |  |                |   |  |                                |     



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



In April 2010, in connection with the issuance of notes payable to Cequent, we issued a
warrant to purchase 565,414 shares of common stock at $1.1496 per share. The warrant provides that the exercise price of the warrant will be reduced in the event of subsequent financings at an effective price per share less than the exercise price
of the warrants. The issuance of this warrant was not a dilutive issuance. The loan warrants are only exercisable, for a five year term, if the merger is not consummated, other than by reason of Cequents material breach of the Cequent Merger
Agreement, and we engage in a transaction that is similar to the proposed merger prior to the one year anniversary of the termination of the Cequent Merger Agreement.

Note 6  Stock Incentive Plans

At March 31, 2010, options to purchase up to 8,334,731 shares of our common stock were outstanding, unvested restricted stock awards
for an aggregate of 16,921 shares of our common stock were outstanding under our 2004 Plan and 265,778 shares were available for future grants or awards under our various stock incentive plans.

We generally issue new shares for option exercises unless treasury shares are available for issuance. We had no treasury shares as of
March 31, 2010 and have no plans to purchase any in the next year, however, we may accept the surrender of vested restricted shares from employees to cover tax requirements at our discretion.

Stock-based Compensation  The following table summarizes stock-based compensation expense (benefit) (in thousands):



|                                    |  |                              |     |   |      |   |    
|----------------------------------- |  | ---------------------------- | --- | - | ---- | - | ---
|                                    |  | Three Months ended March 31,
|                                    |  | 2009                         |     |   | 2010
|Stock-based compensation:           |  |                              |     |   |      |   |    
|Research and development            |  | $                            | (79 | ) |      | $ | 184
|Selling, general and administrative |  |                              | 75  |   |      |   | 299
|                                    |  |                              |     |   |      |   |    
|Total                               |  | $                            | (4  | ) |      | $ | 483
|                                    |  |                              |     |   |      |   |    

Non-cash compensation expense is recognized on a
straight-line basis over the applicable vesting periods, based on the fair value on the grant date. Certain option and share awards provide for accelerated vesting if there is a change in control (as defined in the applicable plan and certain
employment agreements we have with key employees).

Stock Options Stock options to purchase shares of our common
stock are granted under our existing stock-based incentive plans to certain employees, at prices at or above the fair market value on the date of grant. In addition, in June 2008, we granted 1,099,963 options to our Chief Executive Officer, outside
of our stock-based incentive plans as an employment inducement grant.

The following table summarizes stock option activity
during the three months ended March 31, 2010:



|                               |  |           |   |  |                              |      |                                         |           |                         |   |    
|------------------------------ |  | --------- | - |  | ---------------------------- | ---- | --------------------------------------- | --------- | ----------------------- | - | ---
|                               |  | Options   |   |  | WeightedAverageExercisePrice |      | WeightedAverageRemainingContractualLife |           | AggregateIntrinsicValue
|                               |  |           |   |  |                              |      |                                         |           | (in thousands)         
|Outstanding December 31, 2009  |  | 8,430,231 |   |  | $                            | 2.31 |                                         |           |                         |   |    
|Options granted                |  | 4,500     |   |  |                              | 0.95 |                                         |           |                         |   |    
|Options exercised              |  | (75,000   | ) |  |                              | 0.29 |                                         |           |                         |   |    
|Options expired                |  | (25,000   | ) |  |                              | 2.14 |                                         |           |                         |   |    
|Options forfeited or cancelled |  |          |   |  |                              |     |                                         |           |                         |   |    
|                               |  |           |   |  |                              |      |                                         |           |                         |   |    
|Outstanding at March 31, 2010  |  | 8,334,731 |   |  | $                            | 2.33 |                                         | 7.2 years |                         | $ | 390
|                               |  |           |   |  |                              |      |                                         |           |                         |   |    
|Exercisable at March 31, 2010  |  | 4,978,944 |   |  | $                            | 2.63 |                                         | 6.1 years |                         | $ | 354
|                               |  |           |   |  |                              |      |                                         |           |                         |   |    



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



The per-share fair value of stock-options granted was approximately $0.22 and $0.80 in
the three months ended March 31, 2009 and 2010, respectively, which were estimated at the date of grant using the Black-Scholes-Merton option valuation model with the following weighted average assumptions for the periods presented as follows:



|                          |  |                              |   |  |           |  
|------------------------- |  | ---------------------------- | - |  | --------- | -
|                          |  | Three months ended March 31, |  
|                          |  | 2009                         |   |  | 2010      |  
|Expected dividend yield   |  | 0                            | % |  | 0         | %
|Risk free interest rate   |  | 3.8                          | % |  | 3.0       | %
|Expected stock volatility |  | 95                           | % |  | 111       | %
|Expected option life      |  | 5.5 years                    |   |  | 6.0 years |  

As of
March 31, 2010, we had approximately $1.9 million of total unrecognized compensation cost related to unvested stock options. Total unrecognized compensation cost will be adjusted for future changes in estimated forfeitures. We expect to
recognize this cost over a weighted average period of approximately 1.5 years.

The intrinsic value of stock options
outstanding and exercisable at March 31, 2010 is based on the $1.10 closing market price of our common stock on that date, and is calculated by aggregating the difference between $1.10 and the exercise price of each of the outstanding vested
and unvested stock options which have an exercise price less than $1.10. No options were exercised during the three-month period ended March 31, 2009 and 75,000 options were exercised in the three month period ended March 31, 2010. The
total intrinsic value of options exercised during the three months ended March 31, 2010 was approximately $0.1 million. Stock-based compensation expense is recorded net of forfeitures based on historical experience. We recorded stock-based
compensation expense related to the amortization of stock options of approximately $41,000 and $0.4 million in the three-month periods ended March 31, 2009 and March 31, 2010, respectively. The total fair value of options that vested
during the months ended March 31, 2009 and March 31, 2010 was approximately $0.3 million and $0.2 million, respectively.

Non-Employee Option Grants  In the second quarter of 2009 we granted stock options to non-employee members of our
Scientific Advisory Board. Non-employee option grants are recorded as expense over the vesting period of the underlying stock options. At the end of each financial reporting period prior to vesting, the value of these options, as calculated using
the Black-Scholes-Merton option pricing model, is re-measured using the fair value of our common stock and the stock-based compensation recognized during the period is adjusted accordingly. Since the fair value of options granted to non-employees is
subject to change in the future, the amount of future compensation expense will include fair value re-measurements until the stock options are fully vested. We recognized expense of approximately $42,000 in the three months ended March 31,
2010, relating to options granted to non-employee members of our Scientific Advisory Board.

Restricted Stock Awards Pursuant to restricted stock awards granted under our 2004 Stock Incentive Plan, we have issued shares of restricted stock to certain employees and members of our Board. Non-cash compensation expense is recognized on a straight-line basis
over the applicable vesting periods based on the fair value of such restricted stock on the grant date. There were no restricted stock awards granted during the three-month periods ending March 31, 2009 or 2010. Additional information on
restricted shares is as follows:



|                                                          |  |   |        |  
|--------------------------------------------------------- |  | - | ------ | -
|Unvested restricted shares outstanding, December 31, 2009 |  |   | 22,019 |  
|Restricted shares granted                                 |  |   |       |  
|Restricted shares forfeited                               |  |   |       |  
|Restricted shares vested                                  |  |   | (5,098 | )
|                                                          |  |   |        |  
|Unvested restricted shares outstanding, March 31, 2010    |  |   | 16,921 |  
|                                                          |  |   |        |  
|Weighted average grant date fair value per share          |  | $ | 9.64   |  
|                                                          |  |   |        |  

Our total unrecognized compensation cost related to unvested restricted stock awards granted under our 2004
Stock Incentive Plan was approximately $45,000 at March 31, 2010. Total unrecognized compensation cost will be adjusted for future changes in estimated forfeitures. We expect to recognize this cost over a weighted average period of
approximately 0.4 years.

Stock-based compensation recorded related to the amortization of restricted stock grants was a
benefit of approximately $53,000 in the three months ended March 31, 2009, and expense of approximately $43,000 in the three months ended March 31, 2010. The benefit in the 2009 period was due to forfeitures. The fair value of restricted
stock vested during the three-month periods ended March 31, 2009 and 2010 was approximately $100,000 and $27,000.

Employee Stock Purchase Plan A total of 300,000 shares of common stock have been reserved for issuance under our 2007
Employee Stock Purchase Plan (ESPP), of which 183,434 have been issued as of March 31, 2010. Under the terms of the ESPP, a participant may purchase shares of our common stock at a price equal to the lesser of 85% of the fair market
value on the date of offering or on the date of purchase. We recorded stock-based compensation expense related to the ESPP of approximately $8,000 and $17,000 in the three months ended March 31, 2009 and March 31, 2010, respectively.



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##### Table of Contents

MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



Note 7  Contractual Agreements

Roche In February 2009, we entered into an agreement with Hoffman-La Roche Inc., a New Jersey corporation, and F.
Hoffmann-La Roche Ltd., a Swiss corporation (collectively, Roche), pursuant to which we granted to Roche a worldwide, non-exclusive license to a portion of our technology platform, for the development of RNAi-based therapeutics, in
consideration of a one-time non-refundable licensing fee of $5 million, which was recognized as license fee revenue in the three months ended March 31, 2009.

Novartis  In March 2009, we entered into an agreement with Novartis Institutes for BioMedical Research,
Inc. (Novartis), pursuant to which we granted to Novartis a worldwide, non-exclusive license to our DiLA2-based siRNA delivery platform in consideration of a one-time, non-refundable fee of $7.25 million, which was recognized as license fee revenue in the three months ended March 31,
2009. Additionally, we entered into a separate agreement with Novartis to provide them with an exclusive period in which to negotiate a potential research and development collaboration as well as possible broader licensing rights related to our RNAi
drug delivery platform. This exclusive period expired in 2009. Approximately $0.1 million was recognized as license fee revenue in the three months ended March 31, 2009 under this separate agreement.

University of Michigan In May 2008, we entered into an exclusive license agreement to IP from the
University of Michigan covering cationic peptides for enhanced delivery of nucleic acids. These peptides have unique characteristics that we believe play an important role in improving the efficacy of delivery of RNAi-based therapeutics. We are
currently using these peptides to create siRNA nanoparticles to enhance mRNA knockdown. Together with the DiLA2Platform of novel delivery liposomes, these delivery peptides may improve the therapeutic potential of our drug candidates. We sublicensed this IP to Novartis on a nonexclusive basis in 2009.

University of Helsinki In June 2008, we entered into a collaboration agreement with Dr. Pirjo Laakkonen
and the Biomedicum. The goal of the work involves our patented phage display library, the Trp Cage library, for the identification of peptides to target particular tissues or organs for a given disease. In December 2009, we received a patent
allowance in the US covering a targeting peptide for preferential delivery to lung tissues that was identified by MDRNA using the Trp Cage Library. The patent issued in April 2010. We believe Trp Cage will identify additional peptides for evaluation
in our delivery programs, and we will have a strong IP position for these peptides and their use.

Ribotask
ApS. In June 2009, we announced the revision of the agreement established in October 2008, at which time we had acquired the intellectual property related to Unlocked Nucleobase Analogs (UNA) from Ribotask ApS, a privately held Danish
company. The amended agreement eliminated all milestone and royalty payments and provided full financial and transactional control of our proprietary UNA technology. Our UsiRNA construct has been verified in multiple cell and in vivo models
to be highly potent and efficacious for RNAi. Substitution of UNA within siRNA, creating the UsiRNA construct, has been shown to provide greater target specificity. We believe this proprietary construct provides unique advantages for RNAi-based
therapeutics and is an essential part of our business strategy and ultimate success.

University of
British Columbia. In November 2009, we expanded and extended a previous agreement established in 2008 with University of British Columbia/Vancouver Prostate Centre (VPC) in the area of bladder cancer. The VPC is a National Centre for
Excellence for translational research and this agreement provides us access to cutting-edge bladder cancer models and evaluation techniques and interactions with world-renowned researchers and clinicians. Data derived from studies conducted under
this agreement have already demonstrated the potency of UsiRNAs and DiLA2-based delivery for inhibition of target mRNA and reduction in tumor growth. The focus of the expanded agreement will be the evaluation of additional critical targets in bladder cancer
and the therapeutic impact on tumor biology and growth.

Valeant Pharmaceuticals.In March 2010, we acquired
intellectual property related to conformationally restricted nucleotides (CRN) from Valeant Pharmaceuticals North America in consideration of payment of a non-refundable licensing fee due in equal portions in April and July 2010. Under the
agreement, Valeant is entitled to receive additional milestone fees, earn-outs and other payments based upon future progress of the development of a therapeutic product and future commercial sales.

Intranasal related

Amylin Pharmaceuticals, Inc.  In February 2009 we received a milestone payment, in the amount of $1.0 million, which was
recognized as license fee revenue, from Amylin Pharmaceuticals, Inc. (Amylin) under our 2006 Development and License Agreement, as amended, for the development of intranasal exenatide (the License Agreement). The License
Agreement was amended in 2009 to provide for the accelerated $1.0 million milestone payment, and to adjust the aggregate amount of milestone and royalty payments that could be due to us from $89 million to $80 million. We are no longer responsible
for any further development of the nasal spray formulation of intranasal exenatide or its manufacture.



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##### Table of Contents

MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(Continued)

For the three months ended March 31, 2010 and 2009 (Unaudited)



Par Pharmaceutical  In 2009 we entered into an Asset Purchase Agreement
with Par Pharmaceutical (Par) pursuant to which, among other things, a 2004 License and Supply Agreement with Par, and a 2005 Supply Agreement with QOL Medical LLC, were terminated. Under the Asset Purchase Agreement, Par acquired
certain assets pertaining to calcitonin, including our ANDA for generic calcitonin-salmon nasal spray, inventories, tooling and equipment, and the related technology, trade secrets, know-how, proprietary information and other intellectual property
rights, and assumed certain contracts, including our manufacturing obligation to QOL Medical as well as our two building leases related to our operations in Hauppauge, New York. We received $0.8 million in cash and are entitled to receive earn-out
payments for five years based on commercial sales of calcitonin. Calcitonin received full FDA approval and was launched in June 2009. In the three months ended March 31, 2009, we recognized a gain of approximately $0.1 million on the asset sale
to Par which is included as an offset to research and development expense. In the three months ended March 31, 2010 we recognized approximately $0.1 million in revenue relating to earn-out payments based on commercial sales of calcitonin.

Thiakis Limited (Thiakis)  In 2004, we acquired exclusive worldwide rights to the Imperial College
Innovations and Oregon Health & Science University PYY patent applications in the field of nasal delivery of PYY and the use of glucagon-like peptide-1 (GLP-1) used in conjunction with PYY for the treatment of obesity, diabetes and other
metabolic conditions. We recorded $1.2 million in research and development expense in 2008 related to the estimated obligations under this license agreement at December 31, 2008. In April 2009 we entered into a Deed of Release and termination
pursuant to which we agreed to pay $1.1 million, payable in quarterly amounts commencing April 2009 and ending April 2010. The difference between $1.1 million and the amount originally estimated was recorded as reduction of expense in 2009. In
February 2010, we amended the payment schedule for the final two payments totaling $450,000 such that $50,000 was paid in February 2010, $200,000 was paid in April 2010 and a final payment in the amount of $210,000 is due to be paid on or before
May 31, 2010. The final payment includes $10,000 representing interest.

Other

QOL Medical LLC  In October 2005, we entered into a supply agreement with QOL (the QOL
Agreement) under which, subject to certain limitations, we are obligated to manufacture and supply, and QOL is obligated to purchase from us, all of QOLs requirements for
Nascobal® brand products for vitamin B12 (cyanocobalamin) deficiency in patients with pernicious anemia,
Crohns Disease, HIV/ AIDS and multiple sclerosis. Under the terms of the QOL Agreement we received a $2.0 million upfront fee, which was being recognized ratably over the five-year life of the QOL Agreement. In connection with the Asset
Purchase Agreement with Par Pharmaceutical which we entered into in March 2009, the QOL Agreement was terminated. We recognized approximately $0.7 million in deferred revenue related to the Supply Agreement in the three months ended March 31,
2009 and approximately $0.1 million in revenue related to a cancellation fee for cancellation of a planned production batch.

Note 8 
Income Taxes

We continue to record a valuation allowance in the full amount of deferred tax assets since realization of
such tax benefits has not been determined by our management to be more likely than not. At the end of each interim period, we make our best estimate of the effective tax rate expected to be applicable for the full fiscal year, and the rate so
determined is used in providing for income taxes on a current year-to-date basis. The difference between the expected provision or benefit computed using the statutory tax rate and the recorded provision or benefit of zero, is primarily due to the
change in valuation allowance.

Note 9  Commitments and Contingencies

Leases We lease space for our research and development and corporate offices in Bothell, Washington under operating leases
expiring in 2016. In connection with the terms of our lease of our Bothell, Washington facility at 3830 Monte Villa Parkway, we have provided our landlord with a stand-by letter of credit.

In March 2009, we entered into an amendment of our lease for 3450 Monte Villa, pursuant to which we have no lease payment obligations
until July 2010, which reduced our lease obligations by approximately $1.9 million until July 2010. Under terms of the amendment, we released both a cash deposit of approximately $0.3 million and restricted cash under a letter of credit of
approximately $1.0 million to the landlord and issued 1,500,000 shares of our common stock to the landlord. In addition, in July 2009 the landlord leased approximately 37% of the exited facility, and in connection therewith, we entered into an
amendment to our lease agreement which, among other things, terminated the lease with respect to this portion of the premises.

Contingencies We are subject to various legal proceedings and claims that arise in the ordinary course of business. Our
management currently believes that resolution of such legal matters will not have a material adverse impact on our consolidated financial position, results of operations or cash flows.

Note 10  Subsequent Events

As further described in Note 4, on April 30, 2010, Cequent loaned us $1.0 million under the Loan Agreement and in connection
therewith, we issued a warrant to purchase 565,414 shares of common stock at $1.1496 per share.



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##### Table of Contents

ITEM 2  MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL
CONDITION AND RESULTS OF OPERATIONS

Overview

Statements contained herein that are not historical fact may be forward-looking statements within the meaning of Section 27A of
the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are subject to a variety of risks and uncertainties. There are a number of important
factors that could cause actual results to differ materially from those projected or suggested in any forward-looking statement made by us. These factors include, but are not limited to: (i) the ability of our company to obtain additional
funding; (ii) the ability of our company to attract and/or maintain manufacturing, research, development and commercialization partners; (iii) the ability of our company and/or a partner to successfully complete product research and
development, including pre-clinical and clinical studies and commercialization; (iv) the ability of our company and/or a partner to obtain required governmental approvals, including product and patent approvals; (v) the ability of our
company and/or a partner to develop and commercialize products that can compete favorably with those of competitors; and (vi) the failure of the stockholders of MDRNA to approve the proposed merger with Cequent, the failure of either party to
meet any of the other conditions to closing the merger, contractual restrictions on the conduct of our business included in the merger agreement, and any impact on our relationships with third parties as a result of the announcement of the proposed
merger. In addition, significant fluctuations in quarterly results may occur as a result of the timing of milestone payments, the recognition of revenue from milestone payments and other sources, and the timing of costs and expenses related to our
research and development programs. Additional factors that would cause actual results to differ materially from those projected or suggested in any forward-looking statements are contained in our filings with the Securities and Exchange Commission,
including those factors discussed under the caption Forward-Looking Information in our most recent Annual Report on Form 10-K, as may be supplemented or amended from time to time, which we urge investors to consider. We undertake no
obligation to publicly release revisions in such forward-looking statements that may be made to reflect events or circumstances after the date hereof or to reflect the occurrences of unanticipated events or circumstances, except as otherwise
required by securities and other applicable laws.

We are a biotechnology company focused on the discovery, development
and commercialization of pharmaceuticals based on RNA interference (RNAi). Our goal is to be the leader in RNAi therapeutics and improve human health through the development of RNAi-based compounds that provide superior therapeutic
options for patients. Our team of approximately 30 scientists brings expertise in the discovery, evaluation and optimization of small interfering RNAs (siRNAs) as well as siRNA delivery. We have the requisite experience in the areas of
RNAi, molecular and cellular biology, amino acid, oligonucleotide and peptide chemistry, pharmacology and bioinformatics necessary to discover and develop tailored RNAi-based compounds designed to elicit specific therapeutic effects on a
target-by-target basis. Our infrastructure provides for pre-clinical scale manufacturing of both siRNAs and delivery materials, the comprehensive analysis and optimization of these compounds both individually and as drug candidates, and the filing
of Investigational New Drug Applications. In addition to our own, internally developed technologies, we strategically in-license and further develop RNAi- and delivery-related technologies, forming a single integrated drug discovery platform. In
order to protect our innovations, which encompass a broad platform of both siRNA and delivery technologies, and the eventual drug products that emerge from that platform, we will aggressively continue to build upon our extensive and enabling
intellectual property (IP) estate.

Our business strategy is two-fold. First, we strive to
establish collaborations and strategic partnerships with pharmaceutical and biotechnology companies in the area of RNAi-based therapeutics to: (1) generate revenue and non-dilutive financing; (2) gain access to technical resources; and
(3) validate our drug discovery platform. Secondly, we expect to advance our own pipeline of RNAi-based therapeutics as a foundation upon which to improve all aspects of our drug discovery platform and to have the opportunity to commercialize
drug therapies. Our pipeline is focused on bladder and liver cancer. With respect to collaborations and strategic partnerships, we are currently focused on our UsiRNA constructs, as well as our
DiLA2and peptide delivery technologies. Collaborations
are expected to range from feasibility studies to the development of therapeutic candidates. We expect to collaborate with partners who can take a drug candidate through to product commercialization by utilizing their late stage clinical
development, regulatory, marketing and sales capabilities. We expect to structure our collaborative agreements to receive upfront non-refundable payments, research and development funding, milestone payments and royalties on commercial sales of
products.

On March 31, 2010, we entered an Agreement and Plan of Merger (the Cequent Merger Agreement) with
Cequent Pharmaceuticals, a privately-held Delaware corporation, which is developing novel products to deliver RNAi-based therapeutics. The combined company will have multiple proprietary RNAi drug discovery platforms with the capability to deliver
RNAi-based therapeutics via systemic, local and oral administration. In addition, the acquisition expands our oncology pipeline with a product for Familial Adenomatous Polyposis (FAP)  a genetic disorder that is a precursor to colon cancer
 that will soon begin Phase 1 clinical testing under an Investigational New Drug application (IND) filed with the U.S. Food and Drug Administration (FDA). Consummation of the merger is subject to the satisfaction or waiver of customary closing
conditions, including obtaining the requisite approval of our stockholders. The approval of Cequents stockholders was obtained on April 2, 2010. As a result of the proposed merger, Cequent will become our wholly-owned subsidiary.



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We will continue to focus our R&D efforts on RNAi-based therapeutics, and continue to
develop and expand our RNAi technologies and IP estate. As of May 4, 2010, we owned or controlled 17 issued or allowed patent, 41 pending U.S. patent applications, including provisional patent applications, to protect our RNAi proprietary
technologies.

We believe we have established ourselves as a leading RNAi-based therapeutics company by leveraging our broad
and proven expertise in RNAi science and delivery into an industry-leading RNAi drug discovery platform, which is protected by a strong IP position and validated through licensing agreements with two large international pharmaceutical companies.
Because of our collaborations and other agreements, we recognized revenue of approximately $14.2 million and $0.2 million in the quarters ended March 31, 2009 and 2010, respectively.

Cash Position, Going Concern and Recent Financings

The accompanying unaudited condensed consolidated financial statements have been prepared on the basis that we will continue as a going
concern, which contemplates realization of assets and the satisfaction of liabilities in the normal course of business. We have incurred recurring losses and negative cash flows from operations, and have an accumulated deficit (approximately $272.5
million at March 31, 2010) and expect to incur losses in the future as we continue our research and development (R&D) activities. The Report of Independent Registered Public Accounting Firm included in our Annual Report as of
December 31, 2009 stated that these conditions raise substantial doubt about our ability to continue as a going concern. Our operating expenses, primarily R&D in connection with the further development of our RNAi programs, will consume the
majority of our cash resources and will require additional funding. We have funded our losses primarily through the sale of common stock and warrants in the public markets and private placements, revenue provided by our collaboration partners, and,
to a lesser extent, equipment financing facilities and loans.

At March 31, 2010 we had a working capital deficit
(current assets less current liabilities) of $1.0 million and approximately $3.8 million in cash, including approximately $1.2 million in restricted cash. On March 31, 2010, in connection with the execution of the Cequent Merger Agreement, we
entered into a Loan Agreement with Cequent pursuant to which, among other things, Cequent shall extend to us one or more loans in the aggregate principal amount of up to $3.0 million to fund our operations prior to the proposed merger. On
April 30, 2010, Cequent loaned us $1.0 million under the Loan Agreement. We believe that our current resources, including the loans from Cequent, will be sufficient to fund our planned operations into the third quarter of 2010.

We plan to continue to work with large pharmaceutical companies regarding research and development collaboration agreements or
investments, and to pursue public and private sources of financing to raise cash. However, there can be no assurance that we will be successful in such endeavors. The volatility in our stock price, as well as general market conditions, could make it
difficult for us to complete a financing transaction on favorable terms, or at all. Any financing we obtain may further dilute the ownership interest of our current stockholders. If we are unable to obtain additional capital when required, we could
modify, delay or abandon some or all of our programs. These factors, among others, raise substantial doubt about our ability to continue as a going concern. The accompanying condensed consolidated financial statements do not include any adjustments
that may result from the outcome of this uncertainty.

Cash flows

Our operating activities used cash of approximately $4.4 million in the quarter ended March 31, 2010, compared to generating cash of
approximately $7.2 million in the quarter ended March 31, 2009. In the quarter ended March 31, 2010, cash used in operating activities related primarily to funding our net loss, partially offset by changes in the liability for fair value
of price adjustable warrants, stock-based compensation, depreciation and amortization as well as changes in deferred revenue, accounts payable and accrued liabilities. In the quarter ended March 31, 2009, cash generated from operating
activities related primarily to amounts received under our license agreements offset by funding operating expenses and changes in the liability for fair value of price adjustable warrants. We expect to use cash for operating activities in the
foreseeable future as we continue our R&D activities.

Our investing activities used cash of approximately $0.3 million in
the quarter ended March 31, 2010, compared to providing cash of approximately $1.0 million in the quarter ended March 31, 2009. Changes in cash from investing activities result from changes in restricted cash, and sales and purchases of
property and equipment. In 2010 cash used in investing activities was primarily the result of changes in restricted cash, and purchases of property and equipment. In 2009 cash provided by investing activities was primarily the result of sales of
property and equipment.

Our financing activities provided cash of approximately $6.6 million in the quarter ended
March 31, 2010 compared to using cash of approximately $3.7 million in the quarter ended March 31, 2009. Changes in cash from financing activities are primarily due to issuance of common stock and warrants, proceeds and repayment of
equipment financing facilities and notes payable and proceeds from exercises of stock options and warrants. In January 2010, we raised net proceeds of approximately $4.9 million through an offering of shares of common stock and warrants to
purchase shares of common stock and approximately $1.0 million of the proceeds were used to pay off notes payable in January 2010. We also received proceeds of approximately $2.6 million from the exercise of warrants during the first quarter of
2010. In the quarter ended March 31, 2009, our financing activities consisted of paying down our note payable with GECC by approximately $3.7 million.



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Recent Financing Activities

On March 31, 2010, in connection with the execution of the Cequent Merger Agreement, we entered into a Loan Agreement with Cequent
pursuant to which, among other things, Cequent shall extend to us one or more loans in the aggregate principal amount of up to $3.0 million to fund our operations prior to the proposed merger. On April 30, 2010, Cequent loaned us $1.0 million
under the Loan Agreement. The loans are evidenced by a secured promissory note, issued by us to Cequent, which bears interest absent an event of default, at a rate of ten percent per annum. We shall repay the principal and interest of the loans in
three equal consecutive monthly installments, commencing on August 15, 2010 and continuing on the 15th day of each month thereafter through and including October 15, 2010. Notwithstanding the foregoing, if the proposed merger is
consummated prior to August 15, 2010, then, on the closing date of the merger, we shall not owe to any third party any obligations with respect to the loans, including, without limitation, the then outstanding principal balance of the loans and
any interest then accrued but unpaid thereon.

We agreed in the Loan Agreement to issue to Cequent on or about the date of
each loan a warrant to purchase shares of common stock, with each such warrant to be exercisable for a number of shares of common stock equal to sixty-five percent (65%) of the principal amount of the loan being made on such date divided by
$1.1496. The loan warrants are only exercisable, for a five year term, if the proposed merger is not consummated, other than by reason of Cequents material breach of the Cequent Merger Agreement, and we engage in a transaction that is similar
to the proposed merger prior to the one year anniversary of the termination of the Cequent Merger Agreement. Our obligations and the rights of Cequent under each loan warrant will be effective upon the issuance of such loan warrants and will survive
payment of the loans and our other obligations to Cequent under the Loan Agreement and the documents related thereto, and the termination of the Loan Agreement. In April 2010, in connection with the issuance of notes payable to Cequent, we issued a
warrant to purchase 565,414 shares of common stock at $1.1496 per share. The warrant provides that the exercise price of the warrant will be reduced in the event of subsequent financings at an effective price per share less than the exercise price
of the warrants. The issuance of this warrant was not a dilutive issuance.

Summary

We believe that our current resources are sufficient to fund our planned operations into the third quarter of 2010. We based our estimate
on the receipt of planned funding and our ability to perform planned R&D activities. The market value and the volatility of our stock price, as well as general market conditions, could make it difficult for us to complete a financing transaction
on favorable terms, or at all. Any financing we obtain may further dilute or otherwise impair the ownership interests of our current stockholders. If we fail to generate positive cash flows or fail to obtain additional capital when required, we
could modify, delay or abandon some or all of our programs.

Consolidated Results of Operations

Comparison of Quarterly Results of Operations

All amounts, except amounts expressed as a percentage, are presented in thousands in the following table.



|                                                             |  |                             |        |   |        |   |        |   |  |   |         |   |  |      |   
|------------------------------------------------------------ |  | --------------------------- | ------ | - | ------ | - | ------ | - |  | - | ------- | - |  | ---- | --
|                                                             |  | Three Months EndedMarch 31, |        |   | Change |  
|                                                             |  | 2009                        |        |   | 2010   |   |        | $ |  |   | %       |  
|License and other revenue                                    |  | $                           | 14,151 |   |        | $ | 184    |   |  | $ | (13,967 | ) |  | (99  | )%
|                                                             |  |                             |        |   |        |   |        |   |  |   |         |   |  |      |   
|Operating expenses                                           |  |                             |        |   |        |   |        |   |  |   |         |   |  |      |   
|Research and development                                     |  |                             | 4,116  |   |        |   | 3,599  |   |  |   | (517    | ) |  | (13  | )%
|Selling, general and administrative                          |  |                             | 2,107  |   |        |   | 2,559  |   |  |   | 452     |   |  | 21   | % 
|Restructuring                                                |  |                             | 133    |   |        |   | 26     |   |  |   | (107    | ) |  | (80  | )%
|                                                             |  |                             |        |   |        |   |        |   |  |   |         |   |  |      |   
|Total operating expenses                                     |  |                             | 6,356  |   |        |   | 6,184  |   |  |   | (172    | ) |  | (3   | )%
|Interest income                                              |  |                             | 2      |   |        |   |       |   |  |   | (2      | ) |  | (100 | )%
|Interest and other expense                                   |  |                             | (143   | ) |        |   | (780   | ) |  |   | (637    | ) |  | 445  | % 
|Change in fair value liability for price adjustable warrants |  |                             | (1,027 | ) |        |   | (2,710 | ) |  |   | (1,683  | ) |  | 164  | % 
|Gain on settlement of liabilities, net                       |  |                             | 654    |   |        |   |       |   |  |   | (654    | ) |  | (100 | )%
|                                                             |  |                             |        |   |        |   |        |   |  |   |         |   |  |      |   
|Net income (loss)                                            |  |                             | 7,281  |   |        |   | (9,490 | ) |  |   | (16,771 | ) |  | (230 | )%
|                                                             |  |                             |        |   |        |   |        |   |  |   |         |   |  |      |   



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Comparison of the Three Months Ended March 31, 2009 to the Three Months Ended
March 31, 2010

Revenue.We had revenue from certain customers, as a percentage of total revenue, as
follows:



|                       |  |                              |   |  |      |  
|---------------------- |  | ---------------------------- | - |  | ---- | -
|                       |  | Three Months Ended March 31, |  
|                       |  | 2009                         |   |  | 2010 |  
|Par Pharmaceuticals    |  |                             |   |  | 49   | %
|Undisclosed Partner #1 |  |                             |   |  | 20   | %
|Undisclosed Partner #2 |  |                             |   |  | 16   | %
|Novartis               |  | 52                           | % |  |     |  
|Roche                  |  | 35                           | % |  |     |  
|Amylin                 |  | 7                            | % |  |     |  
|QOL Medical, LLC       |  | 6                            | % |  |     |  
|Other                  |  |                             |   |  | 15   | %
|                       |  |                              |   |  |      |  
|Total                  |  | 100                          | % |  | 100  | %
|                       |  |                              |   |  |      |  

License and other revenue.License and other revenue decreased in the quarter ended March 31,
2010 to approximately $0.2 million compared to approximately $14.2 million in the prior year quarter. In the quarter ended March 31, 2009 license and other revenue was primarily from licensing our RNAi platforms including revenue of
approximately $7.3 million from Novartis and $5.0 million from Roche as well as a $1.0 million milestone payment received from Amylin, recognition of approximately $0.7 million in deferred revenue under the QOL agreement and revenue recognized under
the asset purchase agreement with Par. In the quarter ended March 31, 2010 we recognized revenue of approximately $0.1 million as earn-out payments for commercial sales of calcitonin and we recognized approximately $0.1 million in services
revenue under other agreements.

Research and Development.R&D expense consists primarily of salaries and other
personnel-related expenses, costs of pre-clinical studies, consulting and other outside services, laboratory supplies, patent license fees, facilities costs and other costs. We expense all R&D costs as incurred. R&D expense for the quarter
ended March 31, 2010 decreased compared to the 2009 period, due to the following:



| |  |  | Personnel-related expenses increased by 6% to approximately $1.5 million in the quarter ended March 31, 2010 compared to approximately $1.4
million in the quarter ended March 31, 2009 due to an increase in accrued expenses for incentive compensation and recruiting expenses.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Costs of pre-clinical studies, lab supplies, consulting, and outside testing and services increased by 182% to approximately $0.5 million in the
quarter ended March 31, 2010 compared to approximately $0.2 million in the quarter ended March 31, 2009 as we advanced our programs for RNAi therapeutics.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Patent license fees were approximately $0.5 million in the quarter ended March 31, 2010 compared $1.5 million in the prior year period. The 2009
period included approximately $0.9 million in license fees paid in connection with a license agreement that we terminated.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Facilities and equipment costs decreased by 19% to approximately $0.9 million in the quarter ended March 31, 2010 compared to approximately $1.1
million in the quarter ended March 31, 2009 due to a decrease in rent and related expenses as a result of facilities consolidation and a decrease in depreciation of equipment and related maintenance and calibration costs as a result of the sale
or retirement of excess equipment. Depreciation expense included in R&D in the quarter ended March 31, 2010 was approximately $0.4 million, compared with approximately $0.6 million in the quarter ended March 31, 2009.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Stock-based compensation included in R&D expense was approximately $0.2 million in the quarter ended March 31, 2010 compared to a benefit of
approximately $0.1 million in the quarter ended March 31, 2009. The benefit in the prior year period was due to the accounting impact of forfeitures of stock options and restricted stock awards.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | R&D expense by project, as a percentage of total R&D project expense, was as follows:
| | - |  | -------------------------------------------------------------------------------------



|                           |  |                              |   |  |      |  
|-------------------------- |  | ---------------------------- | - |  | ---- | -
|                           |  | Three Months Ended March 31, |  
|                           |  | 2009                         |   |  | 2010 |  
|RNAi Projects              |  | 95                           | % |  | 100  | %
|Legacy Intranasal Projects |  | 5                            | % |  |     | %
|                           |  |                              |   |  |      |  
|Total                      |  | 100                          | % |  | 100  | %
|                           |  |                              |   |  |      |  



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We expect our R&D expenses to increase in 2010 as we advance our programs for RNAi
therapeutics. Our current strategy is focused on entering into collaborations with third parties to participate in the development and, ultimately the commercialization of our RNAi technology.

Selling, general and administrative. Selling, general and administrative expense consists primarily of salaries and other
personnel-related expenses to support our R&D activities, stock-based compensation for selling, general and administrative personnel and non-employee members of our Board, professional fees, such as accounting and legal, corporate insurance and
facilities costs. Selling, general and administrative costs increased in the quarter ended March 31, 2010 compared to the prior year quarter due to the following:



| |  |  | Personnel-related expenses increased by 19% to approximately $0.6 million in the quarter ended March 31, 2010 compared to approximately $0.5
million in the quarter ended March 31, 2009 due to an increase in accrued expenses for incentive compensation.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Costs of legal and accounting fees, consulting, corporate insurance and other administrative costs decreased by 30% to approximately $0.9 million in
the quarter ended March 31, 2010 compared to approximately $1.2 million in the quarter ended March 31, 2009, due primarily to cost containment efforts.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Included in selling, general and administrative expense in the quarter ended March 31, 2010 is approximately $0.6 million in transaction costs
incurred in connection with the proposed merger with Cequent. Transaction costs are expensed as incurred and no merger-related transaction costs were incurred in the same period in 2009.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Facilities and equipment costs decreased by 38% to approximately $0.2 million in the quarter ended March 31, 2010 compared to approximately $0.3
million in the quarter ended March 31, 2009 due to a decrease in rent and related expenses as a result of facilities consolidation.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Stock-based compensation included in selling, general and administrative expense was approximately $0.3 million in the quarter ended March 31,
2010 compared to $0.1 million in the quarter ended March 31, 2009. The increase from the prior year period was due primarily to the accounting impact in 2009 of forfeitures of stock options and restricted stock awards.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We expect general and administrative expenses to increase in 2010 due to additional transaction expenses
expected to be incurred in connection with the proposed merger with Cequent.

Restructuring. Restructuring expense
decreased to approximately $26,000 in the quarter ended March 31, 2010 compared to $133,000 in the same period of 2009 due to lower accretion expense as a result of a decrease in the accrued restructuring liability over the prior year period
and due to a decrease in other facility-related charges.

Interest income.The decrease in interest income in the
quarter ended March 31, 2010 compared to the same period in 2009 was primarily due to lower average interest rates earned on our cash and restricted cash.

Interest and other expense.We incurred interest expense on our notes payable and, in 2009, on our capital lease obligations.
Interest and other expense was approximately $0.8 million in the quarter ended March 31, 2010 compared to $0.1 million in the same period of 2009. Although the average borrowings were lower in 2010, the 2010 expense amount increased over the
prior year period due to amortization of debt issuance costs and non-cash amortization of the fair value of the warrants issued in connection with the 2009 notes payable, which were recorded as debt discount. We expect interest and other expense to
continue to increase in 2010 as a result the Loan Agreement with Cequent.

Change in fair value liability for price
adjustable warrants. We use the Black-Scholes-Merton option pricing model as our method of valuation for price adjustable warrants. The fair value liability is revalued each balance sheet date utilizing Black-Scholes-Merton valuation model
computations with the decrease or increase in fair value being reported in the statement of operations as other income or expense, respectively. The change in fair value liability for price adjustable warrants was a net expense of approximately $2.7
million in the quarter ended March 31, 2010, compared to a net expense of approximately $1.0 million in the same period of 2009. The increase in expense for the quarter ended March 31, 2010 compared to the 2009 period is due primarily to
an increase in the number of warrants outstanding for the 2010 period.

Gain on settlement of liabilities, net. In the
three months ended March 31, 2009 we recorded a net gain on settlement of liabilities of approximately $0.7 million. This included a gain of approximately $0.7 million relating to the amendment of our agreement regarding severance obligations
with our former Chief Scientific Officer. In addition, we recorded a gain of approximately $0.2 million related to the issuance of shares of stock valued at approximately $0.4 million to eight of our vendors to settle amounts due to these vendors of
approximately $0.6 million in total. These gain amounts were partially offset by a lease termination fee of approximately $0.2 million incurred pursuant to the termination of our lease agreement with GECC and subsequent refinance of the amounts due
under our Loan and Security Agreement with GECC. We did not record any gains or losses on settlement of liabilities in 2010.



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Off-Balance Sheet Arrangements

As of March 31, 2010, we did not have any off-balance sheet arrangements, as defined in Item 303(a)(4)(ii) of SEC Regulation
S-K.

ITEM 3  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Not applicable.

ITEM 4  CONTROLS AND PROCEDURES

(a) Disclosure Controls and Procedures. As of the end of the period
covered by this Quarterly Report on Form 10-Q, we carried out an evaluation, under the supervision and with the participation of our senior management, including our Chief Executive Officer and Chief Financial Officer, of the effectiveness of the
design and operation of our disclosure controls and procedures. Based upon that evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures are effective for gathering, analyzing and
disclosing the information that we are required to disclose in reports filed under the Securities Exchange Act of 1934, as amended.

(b) Internal Control Over Financial Reporting.There have been no changes in our internal control over financial reporting during
the fiscal quarter ended March 31, 2010, that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting subsequent to the date we carried out our most recent evaluation.



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PART II  OTHER INFORMATION

ITEM 2  UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

On January 25, 2010, we issued to one of our vendors an aggregate of 50,000 shares of our common stock to settle outstanding amounts
due to such vendors in the amount of $55,000 in total. The shares were offered and sold in reliance on the exemption from registration afforded by Section 4(2) of the Securities Act.

ITEM 6  EXHIBITS

The exhibits required by this item are set forth in the Exhibit Index attached hereto.



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed
on its behalf by the undersigned, duly authorized, in Bothell, State of Washington, on May 17, 2010.



MDRNA, INC.By:

/s/    J. MICHAEL FRENCHJ. Michael French
President and Chief Executive OfficerBy:

/s/    PETER S.
GARCIAPeter S. Garcia
Chief Financial Officer




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EXHIBIT INDEX



|            |  |                                                                                                                                                           
|----------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                               
|            | 
|31.1        |  | Certification of our Chief Executive Officer pursuant to Rules 13a-14 and 15d-14 under the Securities Exchange Act of 1934, as amended. (1)               
|            | 
|31.2        |  | Certification of our Chief Financial Officer pursuant to Rules 13a-14 and 15d-14 under the Securities Exchange Act of 1934, as amended. (1)               
|            | 
|32.1        |  | Certification of our Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. (2)
|            | 
|32.2        |  | Certification of our Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. (2)



|(1) | Filed Herewith.
|--- | ---------------

|(2) | Furnished Herewith.
|--- | -------------------



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