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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

For the Quarter Ended September 30, 2008

Commission File Number 000-13789

MDRNA, INC.

(Exact name of registrant as specified in its charter)



|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 11-2658569                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)
|                                                               | 
|3830 Monte Villa Parkway, Bothell, WA                          |  | 98021                               
|(Address of principal executive offices)                       |  | (Zip Code)                          

Registrants telephone number, including area code: (425) 908-3600

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes  þ    No   ̈

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See
definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act. (Check One):



|                     |  |                      |  |                                               |  |                             
|-------------------- |  | -------------------- |  | --------------------------------------------- |  | ----------------------------
|Large accelerated   ̈ |  | Accelerated filer   ̈ |  | Non-accelerated filer   ̈                      |  | Smaller reporting company  þ
|                     |  |                      |  | (Do not check if a smaller reporting company) |  |                             

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes   ̈    No  þ

Indicate the number of shares outstanding of each of the issuers classes of common stock, as of the latest practicable date:



|                  |  |                                 |  |                   
|----------------- |  | ------------------------------- |  | ------------------
|Date              |  | Class                           |  | Shares Outstanding
|November 10, 2008 |  | Common stock  $0.006 par value |  | 31,246,417        









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##### Table of Contents

MDRNA, INC. AND SUBSIDIARIES

TABLE OF CONTENTS

PART I  FINANCIAL INFORMATION



|                                                                                                                               |  |   
|------------------------------------------------------------------------------------------------------------------------------ |  | --
|ITEM 1  FINANCIAL STATEMENTS (unaudited)                                                                                      |  |   
|Condensed Consolidated Balance Sheets as of December 31, 2007 and September 30, 2008                                           |  | 3 
|Condensed Consolidated Statements of Operations for the three and nine months ended September 
30, 2007 and September 30, 2008 |  | 4 
|Condensed Consolidated Statement of Stockholders Equity and Comprehensive Loss for the nine months ended September 30,
 2008  |  | 5 
|Condensed Consolidated Statements of Cash Flows for the nine months ended September 30, 2007 and
2008                          |  | 6 
|Notes to Condensed Consolidated Financial Statements                                                                           |  | 7 
|ITEM 2  MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF
OPERATIONS                                 |  | 20
|ITEM 3  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK                                                            |  | 36
|ITEM 4  CONTROLS AND PROCEDURES                                                                                               |  | 36
|                                                                                                                              
|PART II  OTHER INFORMATION                                                                                                   
|                                                                                                                               | 
|ITEM 1A  RISK FACTORS                                                                                                         |  | 36
|ITEM 6  EXHIBITS                                                                                                              |  | 37
|SIGNATURES                                                                                                                     |  | 38
|EXHIBIT INDEX                                                                                                                  |  | 39

Items 1, 2, 3, 4 and 5 of PART II have not been included as they are not applicable.



2



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##### Table of Contents

PART I  FINANCIAL INFORMATION

ITEM 1  FINANCIAL STATEMENTS

MDRNA, INC.
AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)



|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------- | -------- | - | ----------------- | - | -------- | -
|                                                                                                                                |  | December 31,2007                                |          |   | September 30,2008 |  
|                                                                                                                                |  | (In thousands, except share and per share data) |         
|ASSETS                                                                                                                          |  |                                                 |          |   |                   |   |          |  
|Current assets:                                                                                                                 |  |                                                 |          |   |                   |   |          |  
|Cash and cash equivalents                                                                                                       |  | $                                               | 27,704   |   |                   | $ | 8,719    |  
|Restricted cash                                                                                                                 |  |                                                 | 2,155    |   |                   |   | 2,155    |  
|Short-term investments                                                                                                          |  |                                                 | 11,714   |   |                   |   |         |  
|Accounts receivable                                                                                                             |  |                                                 | 324      |   |                   |   |         |  
|Inventories                                                                                                                     |  |                                                 | 1,084    |   |                   |   | 98       |  
|Prepaid expenses and other current assets                                                                                       |  |                                                 | 1,698    |   |                   |   | 447      |  
|Assets held for sale                                                                                                            |  |                                                 |         |   |                   |   | 1,005    |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Total current assets                                                                                                            |  |                                                 | 44,679   |   |                   |   | 12,424   |  
|Long-term inventories                                                                                                           |  |                                                 | 1,605    |   |                   |   |         |  
|Property and equipment, net                                                                                                     |  |                                                 | 15,004   |   |                   |   | 8,502    |  
|Other assets                                                                                                                    |  |                                                 | 328      |   |                   |   | 335      |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Total assets                                                                                                                    |  | $                                               | 61,616   |   |                   | $ | 21,261   |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                                            |  |                                                 |          |   |                   |   |          |  
|Current liabilities:                                                                                                            |  |                                                 |          |   |                   |   |          |  
|Accounts payable                                                                                                                |  | $                                               | 4,216    |   |                   | $ | 1,311    |  
|Accrued payroll and employee benefits                                                                                           |  |                                                 | 2,227    |   |                   |   | 1,030    |  
|Accrued restructuring  current portion                                                                                         |  |                                                 | 151      |   |                   |   | 2,723    |  
|Accrued expenses                                                                                                                |  |                                                 | 1,331    |   |                   |   | 595      |  
|Capital lease obligations  current portion                                                                                     |  |                                                 | 4,968    |   |                   |   | 4,854    |  
|Deferred revenue  current portion                                                                                              |  |                                                 | 675      |   |                   |   | 400      |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Total current liabilities                                                                                                       |  |                                                 | 13,568   |   |                   |   | 10,913   |  
|Capital lease obligations, net of current portion                                                                               |  |                                                 | 5,757    |   |                   |   | 1,755    |  
|Deferred revenue, net of current portion                                                                                        |  |                                                 | 718      |   |                   |   | 418      |  
|Accrued restructuring, net of current portion                                                                                   |  |                                                 |         |   |                   |   | 1,385    |  
|Other liabilities                                                                                                               |  |                                                 | 2,353    |   |                   |   | 1,467    |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Total liabilities                                                                                                               |  |                                                 | 22,396   |   |                   |   | 15,938   |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Commitments and contingencies                                                                                                   |  |                                                 |          |   |                   |   |          |  
|Stockholders equity:                                                                                                           |  |                                                 |          |   |                   |   |          |  
|Preferred stock, $0.01 par value; 100,000 authorized: no shares issued and outstanding:                                         |  |                                                 |         |   |                   |   |         |  
|Common stock and additional paid-in capital, $0.006 par value; 90,000,000 authorized:                                           |  |                                                 |          |   |                   |   |          |  
|26,753,430 shares issued and outstanding as of December 31, 2007 and 31,216,059 issued and outstanding as of September 30,
2008 |  |                                                 | 234,065  |   |                   |   | 247,107  |  
|Accumulated deficit                                                                                                             |  |                                                 | (194,865 | ) |                   |   | (241,784 | )
|Accumulated other comprehensive income                                                                                          |  |                                                 | 20       |   |                   |   |         |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Total stockholders equity                                                                                                      |  |                                                 | 39,220   |   |                   |   | 5,323    |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  
|Total liabilities and stockholders equity                                                                                      |  | $                                               | 61,616   |   |                   | $ | 21,261   |  
|                                                                                                                                |  |                                                 |          |   |                   |   |          |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited)



|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|-------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------------- | ------- | - | ------------------------------ | - | ------- | ---- |  | - | ------- | - |  | - | ------- | -
|                                                                                                                                             |  | Three Months EndedSeptember 30,       |         |   | Nine Months EndedSeptember 30, |  
|                                                                                                                                             |  | 2007                                  |         |   | 2008                           |   |         | 2007 |  |   | 2008    |  
|                                                                                                                                             |  | (In thousands, except per share data) |        
|Revenue                                                                                                                                      |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|License and research fees                                                                                                                    |  | $                                     | 1,792   |   |                                | $ | 100     |      |  | $ | 11,197  |   |  | $ | 1,213   |  
|Government grants                                                                                                                            |  |                                       | 105     |   |                                |   | 62      |      |  |   | 307     |   |  |   | 237     |  
|Product revenue                                                                                                                              |  |                                       |        |   |                                |   | 243     |      |  |   | 245     |   |  |   | 972     |  
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Total revenue                                                                                                                                |  |                                       | 1,897   |   |                                |   | 405     |      |  |   | 11,749  |   |  |   | 2,422   |  
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Operating expenses:                                                                                                                          |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Cost of product revenue, including inventory write-down of $0 and $2,579 in the three and nine months ended September 30, 2008,
respectively |  |                                       |        |   |                                |   | 77      |      |  |   | 68      |   |  |   | 2,906   |  
|Research and development                                                                                                                     |  |                                       | 13,774  |   |                                |   | 7,603   |      |  |   | 39,412  |   |  |   | 27,022  |  
|Sales and marketing                                                                                                                          |  |                                       | 517     |   |                                |   | 422     |      |  |   | 1,729   |   |  |   | 1,440   |  
|General and administrative                                                                                                                   |  |                                       | 4,573   |   |                                |   | 2,080   |      |  |   | 12,761  |   |  |   | 9,689   |  
|Restructuring                                                                                                                                |  |                                       |        |   |                                |   | 6,167   |      |  |   |        |   |  |   | 8,084   |  
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Total operating expenses                                                                                                                     |  |                                       | 18,864  |   |                                |   | 16,349  |      |  |   | 53,970  |   |  |   | 49,141  |  
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Loss from operations                                                                                                                         |  |                                       | (16,967 | ) |                                |   | (15,944 | )    |  |   | (42,221 | ) |  |   | (46,719 | )
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Other income (expense):                                                                                                                      |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Interest income                                                                                                                              |  |                                       | 817     |   |                                |   | 69      |      |  |   | 2,722   |   |  |   | 497     |  
|Interest and other expense                                                                                                                   |  |                                       | (300    | ) |                                |   | (195    | )    |  |   | (858    | ) |  |   | (697    | )
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Total other income (expense)                                                                                                                 |  |                                       | 517     |   |                                |   | (126    | )    |  |   | 1,864   |   |  |   | (200    | )
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Net loss                                                                                                                                     |  | $                                     | (16,450 | ) |                                | $ | (16,070 | )    |  | $ | (40,357 | ) |  | $ | (46,919 | )
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Loss per common share  basic and diluted:                                                                                                   |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Net loss per common share  basic and diluted                                                                                                |  | $                                     | (0.66   | ) |                                | $ | (0.52   | )    |  | $ | (1.62   | ) |  | $ | (1.62   | )
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  
|Shares used in computing net loss per share  basic and diluted                                                                              |  |                                       | 25,067  |   |                                |   | 31,003  |      |  |   | 24,844  |   |  |   | 28,986  |  
|                                                                                                                                             |  |                                       |         |   |                                |   |         |      |  |   |         |   |  |   |         |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS EQUITY AND COMPREHENSIVE LOSS

For the Nine Months Ended September 30, 2008

(Unaudited)



|                                                                            |  |                                            |   |             |        |         |                               |   |          |                    |  |   |        |   |  |   |         |  
|--------------------------------------------------------------------------- |  | ------------------------------------------ | - | ----------- | ------ | ------- | ----------------------------- | - | -------- | ------------------ |  | - | ------ | - |  | - | ------- | -
|                                                                            |  | Common Stock and AdditionalPaid-In Capital |   | Accumulated |        |         | AccumulatedOtherComprehensive |   |          | TotalStockholders | 
|                                                                            |  | Shares                                     |   |             | Amount |         | Deficit                       |   |          | Income             |  |   | Equity |  
|                                                                            |  | (In thousands, except share data)          |  
|Balance December 31, 2007                                                   |  | 26,753,430                                 |   |             | $      | 234,065 |                               | $ | (194,865 | )                  |  | $ | 20     |   |  | $ | 39,220  |  
|Sale of common stock and warrants, net                                      |  | 4,590,277                                  |   |             |        | 7,254   |                               |   |         |                    |  |   |       |   |  |   | 7,254   |  
|Compensation related to restricted stock, net of cancellations              |  | (170,080                                   | ) |             |        | 2,175   |                               |   |         |                    |  |   |       |   |  |   | 2,175   |  
|Compensation related to stock options and employee stock purchase plan, net |  | 42,432                                     |   |             |        | 3,613   |                               |   |         |                    |  |   |       |   |  |   | 3,613   |  
|Net loss                                                                    |  |                                           |   |             |        |        |                               |   | (46,919  | )                  |  |   |       |   |  |   | (46,919 | )
|Unrealized loss on securities available for sale                            |  |                                           |   |             |        |        |                               |   |         |                    |  |   | (20    | ) |  |   | (20     | )
|                                                                            |  |                                            |   |             |        |         |                               |   |          |                    |  |   |        |   |  |   |         |  
|Comprehensive loss                                                          |  |                                           |   |             |        |        |                               |   |         |                    |  |   |       |   |  |   | (46,939 | )
|                                                                            |  |                                            |   |             |        |         |                               |   |          |                    |  |   |        |   |  |   |         |  
|Balance September 30, 2008                                                  |  | 31,216,059                                 |   |             | $      | 247,107 |                               | $ | (241,784 | )                  |  | $ |       |   |  | $ | 5,323   |  
|                                                                            |  |                                            |   |             |        |         |                               |   |          |                    |  |   |        |   |  |   |         |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)



|                                                                                   |  |                                |         |   |      |   |         |  
|---------------------------------------------------------------------------------- |  | ------------------------------ | ------- | - | ---- | - | ------- | -
|                                                                                   |  | Nine Months EndedSeptember 30, |        
|                                                                                   |  | 2007                           |         |   | 2008 |  
|                                                                                   |  | (In thousands)                 |        
|Operating activities:                                                              |  |                                |         |   |      |   |         |  
|Net loss                                                                           |  | $                              | (40,357 | ) |      | $ | (46,919 | )
|Adjustments to reconcile net loss to net cash used in operating activities:        |  |                                |         |   |      |   |         |  
|Non-cash compensation related to stock options and employee stock purchase plan    |  |                                | 2,144   |   |      |   | 3,134   |  
|Non-cash compensation related to restricted stock                                  |  |                                | 2,610   |   |      |   | 1,702   |  
|Depreciation and amortization                                                      |  |                                | 3,244   |   |      |   | 3,373   |  
|Loss on retirement of property and equipment                                       |  |                                | 13      |   |      |   | 30      |  
|Write-down of inventory and prepaid supplies                                       |  |                                |        |   |      |   | 2,681   |  
|Non-cash restructuring charges                                                     |  |                                |        |   |      |   | 5,448   |  
|Changes in assets and liabilities:                                                 |  |                                |         |   |      |   |         |  
|Accounts receivable                                                                |  |                                | 2,674   |   |      |   | 324     |  
|Inventories                                                                        |  |                                | 24      |   |      |   | 12      |  
|Prepaid expenses and other assets                                                  |  |                                | 128     |   |      |   | 1,142   |  
|Accounts payable                                                                   |  |                                | (1,058  | ) |      |   | (2,905  | )
|Deferred revenue                                                                   |  |                                | (1,800  | ) |      |   | (575    | )
|Accrued expenses and other liabilities                                             |  |                                | 759     |   |      |   | (1,851  | )
|                                                                                   |  |                                |         |   |      |   |         |  
|Net cash used in operating activities                                              |  |                                | (31,619 | ) |      |   | (34,404 | )
|                                                                                   |  |                                |         |   |      |   |         |  
|Investing activities:                                                              |  |                                |         |   |      |   |         |  
|Purchases of property and equipment                                                |  |                                | (3,524  | ) |      |   | (112    | )
|Proceeds from sales of property and equipment                                      |  |                                |        |   |      |   | 614     |  
|Purchases of investments                                                           |  |                                | (32,747 | ) |      |   | (1,024  | )
|Sales and maturities of investments                                                |  |                                | 38,456  |   |      |   | 12,718  |  
|                                                                                   |  |                                |         |   |      |   |         |  
|Net cash provided by investing activities                                          |  |                                | 2,185   |   |      |   | 12,196  |  
|                                                                                   |  |                                |         |   |      |   |         |  
|Financing activities:                                                              |  |                                |         |   |      |   |         |  
|Borrowings under capital lease obligations                                         |  |                                | 3,802   |   |      |   |        |  
|Payments on capital lease obligations                                              |  |                                | (3,523  | ) |      |   | (4,116  | )
|Proceeds from exercise of stock options and employee stock purchase plan purchases |  |                                | 1,046   |   |      |   | 85      |  
|Proceeds from the issuance of common shares and warrants, net                      |  |                                | 40,923  |   |      |   | 7,254   |  
|                                                                                   |  |                                |         |   |      |   |         |  
|Net cash provided by financing activities                                          |  |                                | 42,248  |   |      |   | 3,223   |  
|                                                                                   |  |                                |         |   |      |   |         |  
|Net increase (decrease) in cash and cash equivalents                               |  |                                | 12,814  |   |      |   | (18,985 | )
|Cash and cash equivalents  beginning of period                                    |  |                                | 28,481  |   |      |   | 27,704  |  
|                                                                                   |  |                                |         |   |      |   |         |  
|Cash and cash equivalents  end of period                                          |  | $                              | 41,295  |   |      | $ | 8,719   |  
|                                                                                   |  |                                |         |   |      |   |         |  
|Supplemental disclosure:                                                           |  |                                |         |   |      |   |         |  
|Cash paid for interest                                                             |  | $                              | 855     |   |      | $ | 697     |  
|                                                                                   |  |                                |         |   |      |   |         |  

See notes to condensed consolidated financial statements



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MDRNA, INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

For the nine months ended September 30, 2007 and 2008 (Unaudited)

Note 1  Description of Business and
Going Concern

Business We are a biotechnology company focused on the development and commercialization of pharmaceuticals
based on RNA interference (RNAi). Our goal is to improve human health through the development of RNAi-based compounds that provide superior therapeutic options for patients. Our team of over 30 scientists with expertise in the discovery,
evaluation and optimization of small interfering RNAs (siRNAs) and delivery technologies have the requisite experience in the areas of RNAi, molecular and cellular biology, lipid and peptide chemistry, pharmacology and bioinformatics
necessary to discover and develop tailored RNAi-based compounds designed to elicit specific therapeutic effects on a target-by-target basis. Our infrastructure provides for pre-clinical scale manufacturing of siRNAs and delivery materials, the
comprehensive analysis and optimization of these compounds both individually and as drug candidates, and the filing of Investigational New Drug Applications. In addition to our own, internally-developed technologies, we strategically in-license and
further develop RNAi- and delivery-related technologies, forming a single integrated drug discovery platform that will be the engine for our clinical pipeline as well as a versatile platform for establishing broad therapeutic partnerships with
biotechnology and pharmaceutical companies. In order to protect our innovations that now encompass a broad platform of both RNAi and delivery technologies, and the eventual drug products that emerge from that platform, we will continue to
aggressively build upon our extensive and enabling intellectual property (IP) estate.

By combining broad and proven expertise
in RNAi science and delivery platforms, a strong IP position, and a pre-clinical pipeline in key therapeutic areas including oncology, metabolic disorders and inflammation, we have established ourselves as a leading RNAi-based therapeutics company.
Our history has been based on nasal delivery; however, our current efforts are almost exclusively devoted to our RNAi programs, and our name has changed from Nastech Pharmaceutical Company Inc. to MDRNA, Inc. We continue to work to identify a
partner or partners to further develop and commercialize our legacy intranasal programs through either a sale or licensing transaction; however, there can be no assurance that we will be able to identify suitable partners for our intranasal programs
or a sale or licensing transaction on terms acceptable to us or at all.

Going Concern The accompanying unaudited condensed
consolidated financial statements have been prepared assuming that we will continue as a going concern, which contemplates realization of assets and the satisfaction of liabilities in the normal course of business for the twelve month period
following the date of these financial statements. As of September 30, 2008, we had an accumulated deficit of approximately $241.8 million and expect to incur additional losses in the future as we continue our research and development
(R&D) activities. We also have negative cash flows, and customers representing a majority of our 2007 revenue have terminated their contractual agreements with us. We have funded our losses primarily through the sale of common stock
and warrants in the public markets and private placements, revenue provided by our collaboration partners and, to a lesser extent, equipment financing facilities. The further development of our RNAi programs will require significant capital. At
September 30, 2008, we had working capital (current assets less current liabilities) of $1.5 million and approximately $10.9 million in cash and cash equivalents, including $2.2 million in restricted cash. While we continue to implement cost
containment efforts, our operating expenses, primarily R&D, will consume a material amount of our cash resources.

We believe that our
current resources are sufficient to fund our planned operations into the first quarter of 2009. We based our estimate on our ability to perform planned R&D activities, the receipt of planned funding and proceeds from assets held for sale. Our
recent decline in market valuation and volatility in our stock price, as well as global market conditions, could make it difficult for us to raise capital on favorable terms, or at all. Any financing we obtain may further dilute or otherwise impair
the ownership interest of our current stockholders. If we fail to generate positive cash flows or fail to obtain additional capital when required, we could modify, delay or abandon some or all of our programs. These factors, among others, raise
substantial doubt about our ability to continue as a going concern. The accompanying unaudited condensed consolidated financial statements do not include any adjustments that may result from the outcome of this uncertainty.

Note 2  Summary of Significant Accounting Policies

Basis of Preparation The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles for interim financial information and in
accordance with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and note disclosures required by U.S. generally accepted accounting principles for complete financial statements.
The accompanying unaudited financial information should be read in conjunction with the audited financial statements, including the notes thereto, as of and for the year ended December 31, 2007, included in our 2007 Annual Report on Form 10-K
filed with the SEC. The information furnished in this report reflects all adjustments (consisting of normal recurring adjustments), which



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are, in the opinion of management, necessary for a fair presentation of our financial position, results of operations and cash flows for each period
presented. The results of operations for the interim periods ended September 30, 2008 are not necessarily indicative of the results for the year ending December 31, 2008 or for any future period.

Principles of Consolidation The financial statements include the accounts of MDRNA, Inc. and our wholly-owned subsidiaries, Atossa
HealthCare, Inc., Nastech Holdings I, LLC, Nastech Holdings II, LLC and MDRNA Research, Inc. (formerly MDRNA, Inc.). All inter-company balances and transactions have been eliminated in consolidation.

Use of Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States
of America requires our management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements, and reported amounts of
revenues and expenses during the reporting periods. Estimates having relatively greater significance include revenue recognition, R&D costs, stock-based compensation, inventory reserves, impairment of long-lived assets, estimated accrued
restructuring charges and income taxes. Actual results could differ from those estimates.

Impairment of Long-Lived Assets, Assets Held
for Sale and Inventory Reserve  Long-lived assets, such as property, equipment and inventory, are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable, in
accordance with Statement of Financial Accounting Standards (SFAS) No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets (SFAS 144). Conditions that would necessitate an impairment include a
significant decline in the observable market value of an asset, a significant change in the extent or manner in which an asset is used, or any other significant adverse change that would indicate that the carrying amount of an asset or group of
assets is not recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to estimated undiscounted future cash flows expected to be generated by the asset. If the carrying amount of an
asset exceeds its estimated future cash flows, an impairment charge is recognized in the amount by which the carrying amount of the asset exceeds the fair value of the asset. Long-lived assets are considered held for sale when certain criteria are
met, including whether management has committed to a plan to sell the asset, whether the asset is available for sale in its immediate condition, and whether the sale is probable within one year of the reporting date.

Estimated Accrued Restructuring Charges Related to Facility Consolidation We follow the provisions of SFAS No. 146, Accounting
for Costs Associated with Exit or Disposal Activities (SFAS 146), as it relates to our facility at 3450 Monte Villa Parkway, Bothell, Washington (3450 Monte Villa), which we have exited as of September 30, 2008.
Under SFAS 146, an accrued liability for remaining lease termination costs is initially measured at fair value, based on the remaining payments due under the lease and other costs, reduced by sublease rental income that could be reasonably obtained
from the property, and discounted using a credit-adjusted risk-free interest rate. We used a credit-adjusted risk-free interest rate of 15%, and we based our sublease expectations on current rental rates available in the Bothell real estate market,
our evaluation of our ability to sublease our facility in light of tightening credit markets, deteriorating conditions in the Bothell real estate market and increased vacancy rates in the competing downtown real estate markets. Accrued
restructuring, and in particular those charges associated with exiting a facility, are subject to managements assumptions and estimates. In addition to the interest rate used, the assumptions as to estimated sublease rental income, the period
of time to execute a sublease and the costs and concessions necessary to enter into a sublease significantly impact the accrual and actual results may differ from our estimates. We review these estimates quarterly and adjust our accrual if
necessary.

Reclassifications  Certain reclassifications have been made to prior years financial statements to conform
with current year presentations. Such reclassifications had no effect on stockholders equity, net loss, or net increase in cash and cash equivalents.

Recent Accounting Pronouncements Effective January 1, 2008, we adopted SFAS No. 157, Fair Value Measurements (SFAS 157), for financial assets and liabilities. This
standard defines fair value, provides guidance for measuring fair value and requires certain disclosures. This standard does not require any new fair value measurements, but rather applies to all other accounting pronouncements that require or
permit fair value measurements and does not apply measurements related to share-based payments. SFAS 157 discusses valuation techniques, such as the market approach (comparable market prices), the income approach (present value of future income or
cash flow), and the cost approach (cost to replace the service capacity of an asset or replacement cost). The statement utilizes a fair value hierarchy that prioritizes the inputs to valuation techniques used to measure fair value into three broad
levels. The following is a brief description of those three levels:

Level 1: Observable inputs such as quoted prices (unadjusted) in active
markets for identical assets or liabilities.

Level 2: Inputs other than quoted prices that are observable for the asset or liability, either directly
or indirectly. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active.

Level 3: Unobservable inputs that reflect the reporting entitys own assumptions.



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Our financial assets subject to fair value measurements and the necessary disclosures are as follows
(amounts in thousands):



|                          |                    |               |         |                                                                         |         |        |         |   |   |  |   |  
|------------------------- | ------------------ | ------------- | ------- | ----------------------------------------------------------------------- | ------- | ------ | ------- | - | - |  | - | -
|                          |                    | Fair Value at |         | Fair value Measurements at September 30, 2008using Fair Value Hierarchy
|                          | September 30, 2008 |               | Level 1 |                                                                         | Level 2 |        | Level 3
|Cash and cash equivalents |                    | $             | 8,719   |                                                                         | $       | 8,719  |         | $ |  |  | $ | 
|Restricted cash           |                    |               | 2,155   |                                                                         |         | 2,155  |         |   |  |  |   | 
|Short-term investments    |                    |               |        |                                                                         |         |       |         |   |  |  |   | 
|                          |                    |               |         |                                                                         |         |        |         |   |   |  |   |  
|Total                     |                    | $             | 10,874  |                                                                         | $       | 10,874 |         | $ |  |  | $ | 
|                          |                    |               |         |                                                                         |         |        |         |   |   |  |   |  

In February 2008, the Financial Accounting Standards Board, or FASB, issued FASB Staff Position
No. FAS 157-2, Effective Date of FASB Statement No. 157, which provides a one year deferral of the effective date of SFAS 157 for non-financial assets and non-financial liabilities, except those that are recognized or disclosed in
the financial statements at fair value at least annually. Therefore, we adopted the provisions of SFAS 157 with respect to our financial assets and liabilities only.

In June 2007, the FASB ratified the consensus reached by the Emerging Issues Task Force (EITF) on EITF Issue No. 07-03, Accounting for Nonrefundable Advance Payments for Goods or Services
Received for Use in Future Research and Development Activities (EITF 07-03). EITF 07-03 provides that nonrefundable advance payments for goods or services that will be used or provided for future R&D activities should
be deferred and capitalized and that such amounts should be recognized as an expense as the related goods are delivered or the related services are performed, and provides guidance with respect to evaluation of the expectation of goods to be
received or services to be provided. We adopted the provisions of EITF 07-03 effective January 1, 2008. The adoption of EITF 07-03 did not have a significant impact on our consolidated financial position or results of operations.

In December 2007, the FASB issued SFAS No. 141(Revised 2007), Business Combinations (SFAS 141R),
which replaces SFAS 141, while retaining the fundamental requirements in SFAS 141 that the acquisition method of accounting be used for all business combinations and that an acquirer be identified for each business combination.
SFAS 141R changes how business acquisitions are accounted for and establishes principles and requirements for how an acquirer recognizes and measures in its financial statements the identifiable assets acquired, the liabilities assumed, any
non-controlling interest in the acquiree and the goodwill acquired both on the acquisition date and in subsequent periods, and also establishes disclosure requirements which will enable users to evaluate the nature and financial effects of the
business combination. SFAS 141R is effective for fiscal years beginning after December 15, 2008. Early adoption is not permitted. The adoption of SFAS 141R will have an impact on future business combinations.

In December 2007, the FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements  an amendment of
Accounting Research Bulletin No. 51 (SFAS 160). SFAS 160 amends Accounting Research Bulletin No. 51 to establish accounting and reporting standards for the non-controlling ownership interests in a
subsidiary and for the deconsolidation of a subsidiary, and changes the way the consolidated statement of operations is presented by requiring consolidated net income (loss) to be reported at amounts that include the amounts attributable to both the
parent and the non-controlling interest, as well as disclosure, on the face of the statement of operations of those amounts. SFAS 160 also establishes a single method of accounting for changes in a parents ownership interest in a
subsidiary that do not result in deconsolidation, and requires gain recognition in income when a subsidiary is deconsolidated. SFAS 160 also requires expanded disclosures that clearly identify and distinguish between the interests of the parent
and the interests of the non-controlling owners. SFAS 160 is effective for fiscal years beginning after December 15, 2008. In the absence of possible future investments, the adoption of SFAS 160 will have no effect on our consolidated
financial statements.

In December 2007, the FASB ratified the consensuses reached in EITF Issue No. 07-1, Collaborative
Arrangements (EITF 07-1). EITF 07-1 defines collaborative arrangements and establishes reporting requirements for transactions between participants in a collaborative arrangement and between participants in the arrangements
and third parties. Under EITF 07-1, payments between participants pursuant to a collaborative arrangement that are within the scope of other authoritative accounting literature on income statement classification should be accounted for using
the relevant provisions of that literature. If the payments are not within the scope of other authoritative accounting literature, the income statement classification for the payments should be based on an analogy to authoritative accounting
literature or if there is no appropriate analogy, a reasonable, rational, and consistently applied accounting policy election. EITF 07-1 also provides disclosure requirements and is effective for fiscal years beginning after December 15,
2008, and interim periods within those fiscal years. The effect of applying EITF 07-1 will be reported as a change in accounting principle through retrospective applications to all prior periods presented for all collaborative arrangements
existing as of the effective date, unless it is impracticable. We must adopt EITF 07-1 no later than our first quarter of fiscal 2009. EITF 07-1 will not have an effect on our assets, liabilities, stockholders equity, cash flows or
net results of operations.



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In June 2008, the FASB issued SFAS No. 162, The Hierarchy of Generally Accepted Accounting
Principles(SFAS 162). SFAS 162 identifies the sources of generally accepted accounting principles and provides a framework, or hierarchy, for selecting the principles to be used in preparing U.S. GAAP financial statements
for nongovernmental entities, and makes the GAAP hierarchy explicitly and directly applicable to preparers of financial statements. The hierarchy of authoritative accounting guidance is not expected to change current practice but is expected to
facilitate the FASBs plan to designate as authoritative its forthcoming codification of accounting standards. This statement is effective 60 days following the SECs approval of the PCAOBs related amendments to remove the GAAP
hierarchy from its auditing standards.

Note 3  Inventories

Inventories, substantially all of which are raw materials, are stated at the lower of cost or
market (first-in, first-out basis). At September 30, 2008, the original cost basis of our inventory was approximately $2.7 million, composed of $0.1 million of Nascobal® active
pharmaceutical ingredient (API) and materials, and $2.6 million of calcitonin-salmon API and materials for our nasal calcitonin-salmon product which is pending U.S. Food and Drug Administration (FDA) approval. Apotex has
filed a generic application for its nasal calcitonin-salmon product with a filing date that has priority over our abbreviated new drug approval (ANDA) for our generic nasal calcitonin-salmon product. In May 2008, a federal district court
dismissed the lawsuit between Novartis and Apotex, due to the parties reaching a settlement in their long-standing litigation. The terms of this settlement were not made public. This created uncertainty over our ability to launch our nasal
calcitonin-salmon product and caused us to reassess the value of our inventory. In the second quarter of 2008, we recorded a non-cash impairment charge of approximately $2.6 million to cost of goods sold related to the write-down of inventory
because we considered the carrying amount of this inventory to likely not be recoverable. It is possible that we may receive partial or full reimbursement under the terms of our contractual arrangement with Par Pharmaceutical Companies, Inc.
(Par Pharmaceutical) should we not be able to use this material in connection with our manufacturing arrangement, but the amount and timing of any such reimbursement are not determinable at this time. For additional discussion of the
status of our collaboration with Par Pharmaceutical, see Note 8: Intellectual Property and Contractual Agreements  Par Pharmaceutical.

Note 4
 Concentration of Credit Risk and Significant Customers

We operate in an industry that is highly regulated, competitive and
rapidly changing and involves numerous risks and uncertainties. Significant technological and/or regulatory changes, the emergence of competitive products and other factors could negatively impact our consolidated financial position or results of
operations.

We are dependent on our collaborative agreements with a limited number of third parties for a substantial portion of our
revenue, and our development and commercialization activities may be delayed or reduced if we do not maintain successful collaborative arrangements. Our agreement with Procter & Gamble Pharmaceuticals, Inc. (P&G) was
terminated in November 2007. In addition, in January 2008, Novo Nordisk A/S (Novo Nordisk) terminated their feasibility study agreement with us. As of the second quarter of 2008, our two feasibility studies with undisclosed partners
had been completed. We had revenue from certain significant customers, as a percentage of total revenue, as follows:



|                                            |  |                                  |   |  |                                 |   |  |      |   |  |      |  
|------------------------------------------- |  | -------------------------------- | - |  | ------------------------------- | - |  | ---- | - |  | ---- | -
|                                            |  | Three Months Ended September 30, |   |  | Nine Months Ended September 30, |  
|                                            |  | 2007                             |   |  | 2008                            |   |  | 2007 |   |  | 2008 |  
|P&G                                         |  | 35                               | % |  | 0                               | % |  | 49   | % |  | 0    | %
|QOL Medical, LLC (QOL)                    |  | 5                                | % |  | 85                              | % |  | 22   | % |  | 55   | %
|Novo Nordisk                                |  | 48                               | % |  | 0                               | % |  | 24   | % |  | 0    | %
|Undisclosed partner  undisclosed compounds |  | 3                                | % |  | 0                               | % |  | 1    | % |  | 23   | %
|Undisclosed partner  Factor IX             |  | 0                                | % |  | 0                               | % |  | 0    | % |  | 11   | %
|                                            |  |                                  |   |  |                                 |   |  |      |   |  |      |  
|Total                                       |  | 91                               | % |  | 85                              | % |  | 96   | % |  | 89   | %
|                                            |  |                                  |   |  |                                 |   |  |      |   |  |      |  

Note 5  Net Loss Per Common Share

Basic and diluted net loss per common share is computed by dividing the net loss by the weighted average number of common shares outstanding during the
period. Diluted loss per share excludes the effect of common stock equivalents (stock options, unvested restricted stock and warrants) since such inclusion in the computation would be anti-dilutive. The following numbers of shares have been excluded
(in thousands):



|                                                               |  |                     |  |       
|-------------------------------------------------------------- |  | ------------------- |  | ------
|                                                               |  | As of September 30,
|                                                               |  | 2007                |  | 2008  
|Stock options outstanding under our various stock option plans |  | 2,415               |  | 7,952 
|Unvested restricted stock                                      |  | 681                 |  | 155   
|Warrants                                                       |  | 661                 |  | 6,197 
|                                                               |  |                     |  |       
|Total                                                          |  | 3,757               |  | 14,304
|                                                               |  |                     |  |       



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Note 6  Stockholders equity and comprehensive loss

Common Stock At our annual meeting of stockholders in June 2008, the stockholders approved an increase in the authorized number of shares of
our common stock from 50,000,000 to 90,000,000. There were no changes to the rights, preferences or privileges of our common stock.

Common Stock Offerings On January 22, 2008, we filed a universal shelf registration statement with the SEC pursuant to which we can issue up to $50.0 million of our common stock, preferred stock, debt securities,
warrants to purchase any of the foregoing securities and units comprised of any of the foregoing securities. The universal shelf registration statement was declared effective by the SEC on February 4, 2008. As of September 30, 2008, we had
approximately $110.4 million remaining on our effective shelf registration statements.

On April 25, 2008, we raised net proceeds of
approximately $7.3 million in a registered direct offering of 4,590,277 shares of common stock along with warrants to purchase up to 5,967,361 shares of common stock at a negotiated purchase price of $1.728 per share. Warrants to purchase up to
4,590,277 shares of common stock are exercisable during the seven-year period beginning October 25, 2008 at a price of $2.376 per share, and warrants to purchase up to 1,377,084 shares of common stock are exercisable during the 90-day period
beginning October 25, 2008 at a price of $2.17 per share. In addition, warrants to purchase up to 229,514 shares of common stock, which are exercisable during the five-year period beginning October 25, 2008 at a price of $2.376 per share,
were issued to the placement agent in connection with the transaction.

Comprehensive Loss Comprehensive loss was $16.4
million and $16.1 million for the three months ended September 30, 2007 and 2008. Comprehensive loss was $40.3 million and $46.9 million for the nine months ended September 30, 2007 and 2008. The only difference between net loss as
reported and comprehensive loss is the change in unrealized gains and losses on available-for-sale securities.

Stockholder Rights Plan In February 2000, our board of directors adopted a stockholder rights plan and declared a dividend of one preferred stock purchase right for each outstanding share of common stock. Each right entitles the holder, once the right becomes
exercisable, to purchase from us one one-thousandth of a share of our Series A Junior Participating Preferred Stock, par value $0.01 per share. We issued these rights in March 2000 to each stockholder of record on such date, and these rights attach
to shares of common stock subsequently issued. The rights will cause substantial dilution to a person or group that attempts to acquire us on terms not approved by our board of directors and could, therefore, have the effect of delaying or
preventing someone from taking control of us, even if a change of control were in the best interest of our stockholders.

Holders of our
preferred share purchase rights are generally entitled to purchase from us one one-thousandth of a share of Series A preferred stock at a price of $50.00, subject to adjustment as provided in the Stockholder Rights Agreement. These preferred share
purchase rights will generally be exercisable only if a person or group becomes the beneficial owner of 15 percent or more of our outstanding common stock or announces a tender offer for 15 percent or more of our outstanding common stock. Each
holder of a preferred share purchase right, excluding an acquiring entity or any of its affiliates, will have the right to receive, upon exercise, shares of our common stock, or shares of stock of the acquiring entity, having a market value equal to
two times the purchase price paid for one one-thousandth of a share of Series A preferred stock. The preferred share purchase rights expire on March 17, 2010, unless we extend the expiration date or in certain limited circumstances, we redeem
or exchange such rights prior to such date. Initially, 10,000 Series A Junior Participating Preferred shares were authorized. In January 2007, this was increased to 50,000 shares, and in June 2008 this was again increased to 90,000 shares, so that a
sufficient number of Series A Junior Participating Preferred shares would be available to the holders of shares of common stock for issuance in satisfaction of such rights, given increases in the number of shares of common stock outstanding.

NASDAQ Deficiency Notice On September 19, 2008, we received a letter from the Listing Qualifications Department of the
NASDAQ Stock Market notifying us that we were not in compliance with the minimum $1.00 per share minimum bid price requirement for continued inclusion on the NASDAQ Global Market set forth in NASDAQ Marketplace Rule 4450(a)(5), as a result of the
bid price of our common stock having closed below $1.00 for the last 30 consecutive



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business days prior to the date of the letter. NASDAQs letter advised us that, in accordance with the NASDAQ Marketplace Rule 4450(e)(2), we will be
provided 180 calendar days, or until March 18, 2009, to regain compliance. The letter further advises that such compliance can be achieved if, at any time before March 18, 2009, the bid price of our common stock closes at $1.00 or more per
share for a minimum of 10 consecutive business days. On October 16, 2008, NASDAQ suspended enforcement of the minimum bid price requirement through January 16, 2009, and accordingly, our date to regain compliance with the continued listing
requirement of NASDAQ Marketplace Rule 4450(a)(5) has been extended to June 22, 2009. There can be no assurance that we will be able to regain compliance with the continued listing requirement of NASDAQ Marketplace Rule 4450(a)(5).

Note 7  Stock-based compensation

The
following table summarizes stock-based compensation expense recorded related to stock-based awards (in thousands):



|                               |  |                                  |       |                                 |   |       |  |      |       |  |   |      
|------------------------------ |  | -------------------------------- | ----- | ------------------------------- | - | ----- |  | ---- | ----- |  | - | -----
|                               |  | Three Months ended September 30, |       | Nine Months ended September 30,
|                               |  | 2007                             |       | 2008                            |   | 2007  |  | 2008
|Stock-based compensation:      |  |                                  |       |                                 |   |       |  |      |       |  |   |      
|Research and development       |  | $                                | 908   |                                 | $ | 1,529 |  | $    | 2,234 |  | $ | 2,982
|Sales and marketing            |  |                                  | 76    |                                 |   | 129   |  |      | 314   |  |   | 365  
|General and administrative     |  |                                  | 869   |                                 |   | 420   |  |      | 2,206 |  |   | 1,489
|                               |  |                                  |       |                                 |   |       |  |      |       |  |   |      
|Total stock-based compensation |  | $                                | 1,853 |                                 | $ | 2,078 |  | $    | 4,754 |  | $ | 4,836
|                               |  |                                  |       |                                 |   |       |  |      |       |  |   |      

Stock Options In June 2008, our 2008 Stock Incentive Plan was approved by our
stockholders and options were issued to certain non-employee directors, non-employee members of our Scientific Advisory Board and employees. An aggregate of 4,500,000 shares of common stock is available for grant pursuant to the 2008 Stock Incentive
Plan. Stock options to purchase shares of our common stock are granted under our existing stock-based incentive plans at prices at or above the fair market value on the date of grant. In addition, in June 2008, we granted 1,099,963 options to our
Chief Executive Officer, outside of our stock-based incentive plans as an employment inducement grant.

Non-cash compensation expense is
recognized on a straight-line basis over the applicable vesting periods of one to five years of the options based on the fair value on the grant date. Certain option and share awards provide for accelerated vesting if there is a change in control
(as defined in the Plan and certain employment agreements we have with key officers). The following summarizes stock option activity during the nine month period ended September 30, 2008:



|                                  |  |                |   |  |                              |       |                                         |           |                         |   |  
|--------------------------------- |  | -------------- | - |  | ---------------------------- | ----- | --------------------------------------- | --------- | ----------------------- | - | -
|                                  |  | Options        |   |  | WeightedAverageExercisePrice |       | WeightedAverageRemainingContractualLife |           | AggregateIntrinsicValue
|                                  |  | (in thousands) |   |  |                              |       |                                         |           | (in thousands)         
|Outstanding December 31, 2007     |  | 2,412          |   |  | $                            | 13.26 |                                         |           |                         |   |  
|Options granted                   |  | 6,272          |   |  |                              | 2.32  |                                         |           |                         |   |  
|Options exercised                 |  |               |   |  |                              |      |                                         |           |                         |   |  
|Options forfeited                 |  | (461           | ) |  |                              | 3.27  |                                         |           |                         |   |  
|Options expired                   |  | (271           | ) |  |                              | 9.42  |                                         |           |                         |   |  
|                                  |  |                |   |  |                              |       |                                         |           |                         |   |  
|Outstanding at September 30, 2008 |  | 7,952          |   |  | $                            | 5.34  |                                         | 8.2 years |                         | $ | 
|                                  |  |                |   |  |                              |       |                                         |           |                         |   |  
|Exercisable at September 30, 2008 |  | 1,977          |   |  | $                            | 13.48 |                                         | 4.0 years |                         | $ | 
|                                  |  |                |   |  |                              |       |                                         |           |                         |   |  

We currently use the Black-Scholes option pricing model to determine the fair value of our
stock-based awards. The determination of the fair value of stock-based awards on the date of grant using an option-pricing model is affected by our stock price as well as by assumptions regarding a number of complex and subjective variables. These
variables include our expected stock price volatility over the term of the awards, actual and projected employee stock option exercise behaviors, risk-free interest rate and expected dividends. Staff Accounting Bulletin (SAB)
No. 107, Share Based Payment (SAB 107) provided for a simplified method for estimating expected term for plain-vanilla options. The mid-point between the vesting date and the expiration date is used as the
expected term under this method. In December 2007, SAB No. 110, Year-End Help for Expensing Employee Stock Options (SAB 110) was released, which extended the use of the simplified method if a company met certain
criteria. We have concluded that we meet the criteria to continue to use the simplified method as we have had significant structural changes in our business such that our historical exercise data may no longer



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provide a reasonable basis upon which to estimate expected term. We have elected to follow the guidance of SAB 107 and SAB 110 and have continued to use the
simplified method in determining expected term for all of our stock option awards to employees and directors, with the exception of stock options granted in June 2008 to our Chief Scientific Officer. We used a 10-year expected term as these options
contractually allow an exercise period up to the full 10-year term of the options.

We estimate volatility of our common stock by using our
stock price history to forecast stock price volatility. The risk-free interest rates used in the valuation model were based on U.S. Treasury issues with remaining terms similar to the expected term on the options. We do not anticipate paying any
dividends in the foreseeable future and, therefore, use an expected dividend yield of zero. Forfeitures are estimated based on historical experience. The fair value of stock-based awards was estimated at the date of grant using the Black-Scholes
option valuation model with the following weighted average assumptions for the periods presented as follows:



|                              |  |                                  |  |      |                                 |   |      |   |           |      |  |   |           |  
|----------------------------- |  | -------------------------------- |  | ---- | ------------------------------- | - | ---- | - | --------- | ---- |  | - | --------- | -
|                              |  | Three months ended September 30, |  |      | Nine months ended September 30, |  
|                              |  | 2007                             |  | 2008 |                                 |   | 2007 |   |           | 2008 | 
|Expected dividend yield       |  | *                                |  |      | 0                               | % |      |   | 0         | %    |  |   | 0         | %
|Risk free interest rate       |  | *                                |  |      | 3.1                             | % |      |   | 4.7       | %    |  |   | 3.5       | %
|Expected stock volatility     |  | *                                |  |      | 75                              | % |      |   | 64        | %    |  |   | 71        | %
|Expected option life          |  | *                                |  |      | 6.0 years                       |   |      |   | 5.8 years |      |  |   | 7.1 years |  
|Fair value of options granted |  | *                                |  | $    | 0.40                            |   |      | $ | 7.65      |      |  | $ | 0.80      |  



|* | No options were granted during the three months ended September 30, 2007.
|- | -------------------------------------------------------------------------

As of September 30, 2008, we had approximately $4.4 million of total unrecognized employee and non-employee director compensation cost related to unvested stock options granted. Total unrecognized compensation
cost will be adjusted for future changes in estimated forfeitures. We expect to recognize this cost over a weighted average period of approximately 1.7 years.

The intrinsic value of stock options outstanding and exercisable at September 30, 2008 is based on the $0.39 closing market price of our common stock on that date, and is calculated by aggregating the difference
between $0.39 and the exercise price of each of the outstanding vested and unvested stock options which have an exercise price less than $0.39. As of that date there were no options outstanding and exercisable which had an exercise price less than
$0.39. The following summarizes stock option activity during the three and nine month periods ended September 30, 2007 and 2008 (in thousands):



|                                     |  |                                  |       |                                 |   |       |  |      |       |  |   |      
|------------------------------------ |  | -------------------------------- | ----- | ------------------------------- | - | ----- |  | ---- | ----- |  | - | -----
|                                     |  | Three months ended September 30, |       | Nine months ended September 30,
|                                     |  | 2007                             |       | 2008                            |   | 2007  |  | 2008
|Intrinsic value of options exercised |  | $                                | 562   |                                 | $ |      |  | $    | 638   |  | $ |     
|Fair value of options that vested    |  |                                  | 1,634 |                                 |   | 2,147 |  |      | 2,826 |  |   | 3,016

At September 30, 2008, options to purchase up to 7,951,807 shares of our common stock were
outstanding, unvested restricted stock awards for an aggregate of 155,076 shares of our common stock were outstanding under our 2004 Plan and 720,934 shares were available for future grants or awards under our various stock incentive plans.

On June 10, 2008, in connection with our annual shareholders meeting, five members of our board of directors retired. Our board of
directors approved a resolution to extend the amount of time the retiring directors have to exercise their vested options from 90 days to two years. Additional compensation expense recognized as a result of the modification was not material. Our
August 2008 workforce reduction included three executives from our intranasal programs. In accordance with the terms of their employment agreements, the vesting of their outstanding unvested options was accelerated as of September 30, 2008. The
related non-cash stock-based compensation expense of $0.4 million was included in restructuring expense in the three and nine month periods ended September 30, 2008.

We generally issue new shares for option exercises unless treasury shares are available for issuance. We have no treasury shares as of September 30, 2008 and have no plans to purchase any in the next year,
however, we may accept the surrender of vested restricted shares from employees to cover tax requirements at our discretion.

Non-Employee Option Grants  In June 2008 we granted stock options to four non-employee members of our Scientific Advisory Board. For stock options granted as consideration for services rendered by non-employees, we
recognize compensation expense in accordance with the requirements of SFAS 123(R), EITF Issue No. 96-18, Accounting for Equity Instruments that are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or
Services and EITF Issue No. 00-18 Accounting Recognition for Certain Transactions involving Equity Instruments Granted to Other



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Than Employees, as amended. Non-employee option grants are recorded as an expense over the vesting period of the underlying stock options. At the end
of each financial reporting period prior to vesting, the value of these options, as calculated using the Black-Scholes option pricing model, will be re-measured using the fair value of our common stock and the non-cash compensation recognized during
the period will be adjusted accordingly. Since the fair value of options granted to non-employees is subject to change in the future, the amount of future compensation expense will include fair value re-measurements until the stock options are fully
vested. During the three and nine month periods ended September 30, 2008, we recognized expense of approximately $14,000 and $52,000, respectively, relating to options granted to non-employee members of our Scientific Advisory Board.

Restricted Stock Awards Pursuant to restricted stock awards granted under our 2004 Stock Incentive Plan, we have issued
shares of restricted stock to certain employees and members of our board of directors. Non-cash compensation expense is recognized on a straight-line basis over the applicable vesting periods of one to four years of the restricted shares based on
the fair value of such restricted stock on the grant date. Certain share awards provide for accelerated vesting if there is a change in control (as defined in the Plan and certain employment agreements which we have with key officers). We granted
restricted stock awards representing 167,985 shares of common stock with a per share weighted average fair value of $11.30 in the three month period ending September 30, 2007. No restricted stock awards were granted in the three month period
ended September 30, 2008. We granted restricted stock awards representing 325,403 and 66,429 shares of common stock with a per share weighted average fair value of $11.92 and $2.28 in the nine month periods ending September 30, 2007 and
2008. Additional information on restricted shares is as follows (in thousands, except per share amounts):



|                                                         |  |                  |   |  |                                     |      
|-------------------------------------------------------- |  | ---------------- | - |  | ----------------------------------- | -----
|                                                         |  | RestrictedShares |   |  | WeightedAverageGrant DateFair Value
|                                                         |  | (in thousands)   |   |  |                                    
|Unvested restricted shares outstanding December 31, 2007 |  | 610              |   |  | $                                   | 12.89
|Restricted shares granted                                |  | 67               |   |  |                                     | 2.28 
|Restricted shares forfeited                              |  | (237             | ) |  |                                     | 12.26
|Restricted shares vested                                 |  | (285             | ) |  |                                     | 12.28
|                                                         |  |                  |   |  |                                     |      
|Outstanding at September 30, 2008                        |  | 155              |   |  | $                                   | 10.43
|                                                         |  |                  |   |  |                                     |      

The fair value of restricted stock vested during the three month periods ended September 30,
2007 and 2008 was approximately $1.5 million and $1.9 million. The fair value of restricted stock vested during the nine month periods ended September 30, 2007 and 2008 was approximately $2.6 million and $3.5 million.

Our total unrecognized compensation cost related to unvested restricted stock awards granted under our 2004 Stock Incentive Plan was approximately $3.3
million at September 30, 2008. Total unrecognized compensation cost will be adjusted for future changes in estimated forfeitures. We expect to recognize this cost over a weighted average period of approximately 1.5 years.

On June 10, 2008, in connection with our annual shareholders meeting, five members of our board of directors retired. Our board of directors
approved a resolution to accelerate the vesting of approximately 21,320 restricted shares which would have vested for the retiring directors over the next one or two years. Additional compensation expense recognized as a result of the modification
was not material. Our August 2008 workforce reduction included three executives from our intranasal programs. In accordance with the terms of their employment agreements, the vesting of all of their outstanding unvested restricted stock awards was
accelerated as of September 30, 2008. The related non-cash stock-based compensation expense in the amount of $0.5 million was included in restructuring expense in the three and nine month periods ended September 30, 2008.



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Employee Stock Purchase Plan In June 2007, our shareholders approved the adoption of our
2007 Employee Stock Purchase Plan (ESPP). A total of 300,000 shares of common stock were reserved for issuance under our ESPP. Under the terms of our ESPP, a participant may purchase shares of our common stock at a price equal to the
lesser of 85% of the fair market value on the date of offering or on the date of purchase. Our initial six-month purchase period started October 1, 2007 and ended on March 31, 2008. On April 1, 2008, 42,432 shares of common stock were
purchased under the ESPP at $2.00 (85% of the market value of $2.35 on March 31, 2008). Our second six-month purchase period started April 1, 2008 and ended October 1, 2008. On October 1, 2008, 32,159 shares of common stock were
purchased under the ESPP at $0.33 (85% of the market value of $0.39 on September 30, 2008). The amount expensed related to our ESPP in the three and nine month periods ended September 30, 2008 was $26,000 and $99,000 based on employee
contributions and on the following weighted average variables:



|                        |  |                                 |  |      |                                |   |      |   |      |   |           |  
|----------------------- |  | ------------------------------- |  | ---- | ------------------------------ | - | ---- | - | ---- | - | --------- | -
|                        |  | Three months endedSeptember 30, |  |      | Nine months endedSeptember 30, |  
|                        |  | 2007                            |  | 2008 |                                |   | 2007 |   | 2008 |  
|Expected dividend yield |  | *                               |  |      | 0                              | % |      | * |      |   | 0         | %
|Risk free interest rate |  | *                               |  |      | 1.5                            | % |      | * |      |   | 3.8       | %
|Expected volatility     |  | *                               |  |      | 130                            | % |      | * |      |   | 76        | %
|Expected term           |  | *                               |  |      | 0.5 years                      |   |      | * |      |   | 0.5 years |  
|Fair value              |  | *                               |  | $    | 1.19                           |   |      | * |      | $ | 3.27      |  



|* | The ESPP began on October 1, 2007.
|- | ----------------------------------

Warrants In connection with offerings of our common stock, we have issued warrants to purchase shares of our common stock. At December 31, 2007, there were warrants outstanding for the purchase of 144,430 shares of our common stock with an
exercise price of $11.09 which expired in September 2008. On April 25, 2008, we raised net proceeds of approximately $7.3 million in a registered direct offering of 4,590,277 shares of common stock along with warrants to purchase up to
5,967,361 shares of common stock at a negotiated purchase price of $1.728 per share. Warrants to purchase up to 4,590,277 shares of common stock are exercisable during the seven-year period beginning October 25, 2008 at a price of $2.376 per
share, and warrants to purchase up to 1,377,084 shares of common stock are exercisable during the 90-day period beginning October 25, 2008 at a price of $2.17 per share. In addition, warrants to purchase up to 229,514 shares of common stock,
which are exercisable during the five-year period beginning October 25, 2008 at a price of $2.376 per share, were issued to the placement agent in connection with the transaction. The warrants were evaluated under the guidance set forth in EITF
Issue No. 00-19, Accounting for Derivative Financial Instruments Indexed to, and Potentially Settled in, a Companys Own Stock (EITF 00-19). We considered the provisions of EITF 00-19 with respect to the warrants and
concluded that the warrants may be physically or net-share settled at the investors option and do not contain any net-cash settlement provisions or any provisions deemed under EITF 00-19 to be equivalent to net-cash settlement provisions and
are appropriately classified as equity. The following summarizes warrant activity during the nine month period ended September 30, 2008 (in thousands).



|                                                    |  |   |       |  
|--------------------------------------------------- |  | - | ----- | -
|Warrants outstanding, December 31, 2007             |  |   | 144   |  
|Warrants issued                                     |  |   | 6,197 |  
|Warrants exercised                                  |  |   |      |  
|Warrants expired                                    |  |   | (144  | )
|                                                    |  |   |       |  
|Warrants outstanding, September 30, 2008            |  |   | 6,197 |  
|                                                    |  |   |       |  
|Weighted average exercise price, September 30, 2008 |  | $ | 2.33  |  
|                                                    |  |   |       |  

Note 8  Intellectual Property and Contractual Agreements

RNAi-related

City of Hope In November
2006, we entered into a license with the Beckman Research Institute/City of Hope for exclusive and non-exclusive licenses to the Dicer-substrate RNAi IP developed there. City of Hope granted non-exclusive rights under the licensed patent
applications for the treatment of all human diseases, less certain infectious diseases, as well as exclusive rights to five named respiratory viral targets. Our rights under the licenses, including sublicensing, are subject to certain limitations.
We believe these limitations will have no impact on our programs. This IP and technology, which we continue to build upon as part of our own IP and technology estate, could provide significant commercial and therapeutic advantages for us in this
field, by enabling the use of 25 to 30 base pair RNA duplexes designed to act as substrates for processing by the target cells natural ability to modulate protein expression.



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University of Michigan In May 2008,
we entered into an exclusive license agreement to IP from the University of Michigan covering cationic peptides for enhanced delivery of nucleic acids. These peptides have unique characteristics that we believe play an important role in improving
the efficacy of delivery of RNAi-based therapeutics. We are currently using these peptides to create siRNA nanoparticles to enhance gene expression knockdown. Together with the DiLA2Platform of novel delivery lipids, these delivery peptides improve the therapeutic potential of our drug candidates.

University of Helsinki In June 2008, we entered into a collaboration with
Dr. Pirjo Laakkonen and the Biomedicum Helsinki to screen our patented phage display library, the Trp Cage library. The goal of the work is to discover and evaluate peptides for their potential to be incorporated into our siRNA formulations to
contribute to targeting particular tissues or organs indicated in a given disease. We expect to use the peptides to improve and increase the delivery options for siRNA, including nanoparticle technology and the combination of novel peptides with our
DiLA2Platform.

Université
Laval (Quebec)  We are collaborating with Université Laval in the area of therapeutic siRNAs against pulmonary viruses including respiratory syncytial virus (RSV) and human metapneumovirus.

Government Grants In September 2006, the National Institutes of Health, or NIH, awarded us a $1.9 million grant over a five year
period to prevent and treat influenza. Revenue recognized under this grant totaled $0.1 million for both the three month periods ended September 30, 2007 and 2008. Revenue recognized under this grant totaled $0.3 million for the nine month
period ended September 30, 2007 and $0.2 million for the nine month period ended September 30, 2008.

Alnylam Pharmaceuticals,
Inc. (Alnylam) In July 2005, we acquired an exclusive InterfeRx license from Alnylam to discover, develop, and commercialize RNAi therapeutics directed against TNF-alpha, a protein associated with inflammatory diseases
including rheumatoid arthritis and certain chronic diseases. Under the agreement, Alnylam received an initial license fee from us and would receive annual and milestone fees and royalties on sales of any products covered by the licensing agreement.
We expensed the initial license fee as R&D expense in 2005. That agreement specified a three-year discovery period with an option to convert a research program to a development and commercialization program. We previously waived our rights to
other open targets under the license from Alnylam. In 2006, we licensed IP from City of Hope for Dicer substrate. Based on this licensed IP as well as results from our own efforts in siRNA chemistries and deliveries, we chose to proceed with a Dicer
substrate against TNF-alpha. As a result, we allowed our agreement with Alnylam to expire in July 2008.

Intranasal related

Procter & Gamble Pharmaceuticals, Inc. In January 2006, we entered into a Product Development and License Agreement with P&G to
develop and commercialize our PTH(1-34) nasal spray for the treatment of osteoporosis and in December 2006, we entered into the First Amendment to the License Agreement. Under our agreements with P&G, we received an initial $10.0 million cash
payment, which was recorded as deferred revenue and was being amortized into revenue over the estimated development period, a $7.0 million milestone payment received and recognized in full as revenue in the second quarter of 2006, and $11.9 million
and $4.3 million in R&D reimbursements recognized as revenue in 2006 and 2007, respectively. Our agreements with P&G were terminated in November 2007, at which time we reacquired all rights and data associated with the PTH(1-34) program. The
unamortized balance of P&Gs $10.0 million initial payment, approximately $5.5 million, was recognized as revenue in the fourth quarter of 2007.

Amylin Pharmaceuticals, Inc. (Amylin) In June 2006, we entered into an agreement with Amylin to develop a nasal spray formulation of exenatide for the treatment of type 2 diabetes. Under
terms of the agreement, we will receive milestone payments and royalties on product sales. If the development program is successful and the product continues to move forward, milestone payments could reach up to $89 million in total, based on
specific development, regulatory, and commercialization goals. Royalty rates escalate with product success. Under the terms of our agreement with Amylin, we will jointly develop the nasal spray formulation with Amylin utilizing our proprietary nasal
delivery technology, and Amylin will reimburse us for any development activities we perform under the agreement. Amylin has overall responsibility for the development program including clinical, non-clinical and regulatory activities, and our
efforts will focus on drug delivery and CMC activities. If a supply agreement is reached between the companies, we may supply commercial product to Amylin and their exenatide collaboration partner, Eli Lilly and Company, however, there can be no
assurance that such a supply agreement will be executed.

Par Pharmaceutical In October 2004, we entered into a license and
supply agreement with Par Pharmaceutical for the exclusive U.S. distribution and marketing rights to a generic calcitonin-salmon nasal spray for the treatment of osteoporosis, which is pending FDA approval. Under the terms of the agreement, we will
manufacture and supply finished calcitonin-salmon nasal spray product to Par Pharmaceutical, while Par Pharmaceutical will distribute the product in the U.S. The financial terms of the agreement include milestone payments, product transfer payments
for manufactured product and a profit sharing following commercialization. At September 30, 2008, the original cost basis of our inventory was



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approximately $2.7 million, composed of $0.1 million of Nascobal® API and materials, and $2.6
million of calcitonin-salmon API and materials for our nasal calcitonin-salmon product. Apotex has filed a generic application for its nasal calcitonin-salmon product with a filing date that has priority over our ANDA for our generic nasal
calcitonin-salmon product. In May 2008, the federal district court dismissed the lawsuit brought by Novartis against Apotex, due to the parties reaching a settlement in their long-standing litigation. The terms of this settlement were not made
public. This created uncertainty over our ability to launch our nasal calcitonin-salmon product and has caused us to reassess the value of our inventory. In the second quarter of 2008, we recorded a non-cash impairment charge of approximately $2.6
million to cost of goods sold related to the write-down of inventory because we considered the carrying amount of this inventory to likely not be recoverable. It is possible that we may receive partial or full reimbursement under the terms of our
contractual arrangement with Par Pharmaceutical should we not be able to use this material in connection with our manufacturing arrangement, but the amount and timing of any such reimbursement are not determinable at this time.

Thiakis Limited (Thiakis)  In September 2004, we acquired exclusive worldwide rights to the Imperial College Innovations and
Oregon Health & Science University PYY patent applications in the field of nasal delivery of PYY and the use of glucagon-like peptide-1 (GLP-1) used in conjunction with PYY for the treatment of obesity, diabetes and other metabolic
conditions. Under the agreement, we made an equity investment in and paid an initial license fee to Thiakis. We expensed the equity investment and initial license fee as R&D expense in 2004. Under the agreement, Thiakis is entitled to receive an
annual fee, additional milestone fees, patent-based royalties, and additional equity investments based upon future progress of the IP and product development processes. On November 5, 2008, we gave notice to terminate our agreement with
Thiakis.

Other

Questcor Pharmaceuticals, Inc. (Questcor)/QOL In October 2005, we received $2.0 million from Questcor Pharmaceuticals Inc. (Questcor) as consideration for our consent to the
assignment of the 2003 Questcor Asset Purchase and Supply Agreement (the QOL Agreement) and in connection with our entering into an agreement with QOL Medical, LLC (QOL) that modified certain terms of the QOL Agreement. Under
the terms of the, the QOL Agreement, subject to certain limitations, we are obligated to manufacture and supply, and QOL is obligated to purchase from us, all of QOLs requirements for Nascobal® brand products. The $2.0 million is being recognized ratably over the five-year life of the QOL Agreement. QOL also assumed Questcors obligation to pay us $2.0 million on the issuance by the
U.S. Patent and Trademark Office (PTO) of a patent covering any formulation that treats any indication identified in our NDA for Nascobal® nasal spray. This payment became
due and was received and recognized as revenue in the second quarter of 2007. We recognized product revenue relating to the supply agreement of approximately $0 and $0.2 million in three months ended September 30, 2007 and 2008, respectively,
and approximately $0.2 million and $0.9 million in the nine months ended September 30, 2007 and 2008, respectively.

Cytyc
Corporation (Cytyc) In July 2003, we entered into a five-year agreement with Cytyc pursuant to which Cytyc acquired patent rights to our Mammary Aspirate Specimen Cytology Test device. Under the terms of the agreement, we
received a license fee from Cytyc in 2003 and reimbursement for the cost of patent maintenance and further patent prosecution if incurred during the term of the agreement. In July 2008, the agreement term lapsed and all rights reverted to us. We
intend to surrender the rights to this device to a related party in the fourth quarter of 2008, in consideration of such partys assumption of all liabilities related to the device.

Feasibility Agreements We have entered into various feasibility agreements, which are generally for terms of one year or less, including
Novo Nordisk and other undisclosed partners. In January 2008, Novo Nordisk completed their feasibility study agreement with us and decided not to further advance the work. As of the second quarter of 2008, our two feasibility studies with
undisclosed partners had been completed.

Note 9  Commitments and Contingencies

Leases We lease space for our manufacturing, R&D and corporate offices in Bothell, Washington under operating leases expiring in 2016
and for manufacturing, warehousing and R&D activities in Hauppauge, New York under operating leases expiring in June 2010. In connection with the terms of the leases of our Bothell, Washington facilities, we provided our landlords with stand-by
letters of credit that total approximately $2.2 million.

We have entered into a capital lease agreement with GE Capital Corporation, which
allows us to finance certain property and equipment purchases over three-or four-year terms depending on the type of equipment. Under this agreement, we have purchased assets approved by GE Capital Corporation, at which date GE Capital Corporation
assumes ownership of the assets and we are reimbursed. The equipment is then leased to us. We borrowed approximately $0.8 million and $0 in the nine months ended September 30, 2007 and 2008, respectively. Weighted average interest rates on
capital lease borrowings were approximately 10.4% and 9.9%, respectively, for the three and nine month periods ended September 30, 2007 and 10.7% and 10.6% for the three and nine month periods ended September 30, 2008.



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Contingencies We are subject to various legal proceedings and claims that arise in the
ordinary course of business. Our management currently believes that resolution of such legal matters will not have a material adverse impact on our consolidated financial position, results of operations or cash flows.

Note 10  Accrued Restructuring and Assets Held for Sale

Commencing in the fourth quarter of 2007 and continuing in the first nine months of 2008, we implemented plans to restructure operations to concentrate resources on key programs, and we continue to focus on maximizing the performance of our
business and controlling costs to respond to the economic environment. In connection with these operational changes, we suspended further clinical development of our intranasal programs. We have reduced our workforce from approximately 235 employees
in late 2007 to approximately 58 full-time employees as of September 30, 2008, including approximately six full-time-equivalents maintaining our manufacturing, quality assurance and quality control operations in support of our current
partnerships. We have recorded restructuring charges related to employee termination costs, our facility consolidation and impairment of assets in accordance with our long-lived assets policy (see Note 2). In addition, we also incurred approximately
$0.3 million related to our decision in the first quarter 2008 to place our Phase 2 PTH(1-34) clinical trial on hold until further funding has been obtained. We continue to work to identify a partner or partners to further develop and commercialize
our legacy intranasal programs through either a sale or licensing transaction; however, there can be no assurance that we will be able to identify suitable partners for our intranasal programs or a sale or licensing transaction on terms acceptable
to us or at all.

Our August 2008 workforce reduction included three executives from our intranasal programs. As previously disclosed in
Note 7, in accordance with the terms of their employment agreements, the vesting of their outstanding unvested options and restricted stock was accelerated as of September 30, 2008. The related non-cash stock-based compensation expense of
approximately $0.9 million was included in restructuring expense in the three and nine month periods ended September 30, 2008. We also incurred an additional $1.5 million in employee termination costs in the third quarter of 2008.

During the third quarter of 2008, we closed our facility at 3450 Monte Villa and we began marketing the facility for a sublease tenant. We have
recorded a restructuring liability of approximately $3.1 million, representing remaining lease payments due under the lease and other costs, reduced by sublease rental income that could be reasonably obtained from the property, and discounted using
a credit-adjusted risk-free interest rate. We used a credit-adjusted risk-free interest rate of 15%, and we based our sublease expectations on current rental rates available in the Bothell real estate market, our evaluation of our ability to
sublease our facility in light of tightening credit markets, deteriorating conditions in the Bothell real estate market and increased vacancy rates in the competing downtown real estate markets. The related deferred rent liability of approximately
$1.0 million was recorded as a reduction to restructuring expense in the three months ended September 30, 2008. We also incurred approximately $0.1 million in additional costs associated with the September 2008 exit of our 3450 Monte Villa
facility. We expect to incur approximately $1.0 million in accretion expense through the expiration of our 3450 Monte Villa lease in January 2016. As of September 30, 2008, we believe we have completed the employee terminations and facility
closures related to our restructuring plans. We will continue to negotiate an early termination or sublease of the 3450 Monte Villa facility lease to further reduce fixed operating costs.

Given the triggering event as a result of the employee terminations and facility consolidation, we have evaluated our long-lived assets for possible
impairment under the guidance in SFAS 144. In the third quarter of 2008, leasehold improvements having a net book value of approximately $1.5 million were considered impaired by management as they related to our exited facility. A related charge has
been included in restructuring expense for the three and nine months ended September 30, 2008. At the end of the second quarter of 2008, laboratory and manufacturing equipment having a net realizable value of approximately $0.4 million, net of
estimated costs to sell, was held for sale. We completed the sale of these assets in the third quarter of 2008. During the third quarter of 2008, we had additional sales of property and equipment totaling $0.3 million in net realizable value, less
costs to sell, and the net loss on sale of approximately $63,000 was included in restructuring expense for the three and nine month periods ended September 30, 2008. At September 30, 2008, property and equipment having a net realizable
value of approximately $1.0 million, net of estimated costs to sell, was held for sale.

Accrued restructuring, and in particular those
charges associated with exiting a facility, are subject to managements assumptions and estimates. In addition to the interest rate used, the assumptions as to estimated sublease rental income, the period of time to execute a sublease and the
costs and concessions necessary to enter into a sublease significantly impact the accrual and actual results may differ from our estimates.



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The components of restructuring are summarized as follows (in thousands):



|                                            |  |                                 |   |                                |   |       |  |      |   |  |   |      
|------------------------------------------- |  | ------------------------------- | - | ------------------------------ | - | ----- |  | ---- | - |  | - | -----
|                                            |  | Three Months endedSeptember 30, |   | Nine Months endedSeptember 30,
|                                            |  | 2007                            |   | 2008                           |   | 2007  |  | 2008
|Employee severance and termination benefits |  | $                               |  |                                | $ | 2,363 |  | $    |  |  | $ | 3,986
|Property and equipment impairment           |  |                                 |  |                                |   | 1,592 |  |      |  |  |   | 1,592
|Facility related charges                    |  |                                 |  |                                |   | 2,212 |  |      |  |  |   | 2,212
|Other restructuring charges                 |  |                                 |  |                                |   |      |  |      |  |  |   | 294  
|                                            |  |                                 |   |                                |   |       |  |      |   |  |   |      
|Total restructuring                         |  | $                               |  |                                | $ | 6,167 |  | $    |  |  | $ | 8,084
|                                            |  |                                 |   |                                |   |       |  |      |   |  |   |      

The following table reflects the activity in accrued restructuring for the nine months ended
September 30, 2008 (in thousands):



|                            |  |                                         |        |   |                        |   |       |       |  |   |       |   |  |   |        |  
|--------------------------- |  | --------------------------------------- | ------ | - | ---------------------- | - | ----- | ----- |  | - | ----- | - |  | - | ------ | -
|                            |  | EmployeeSeveranceandTerminationBenefits |        |   | FacilityRelatedCharges |   |       | Other |  |   | Total |  
|Balance, December 31, 2007  |  | $                                       | 151    |   |                        | $ |      |       |  | $ |      |   |  | $ | 151    |  
|Additional accruals         |  |                                         | 3,119  |   |                        |   | 3,180 |       |  |   | 294   |   |  |   | 6,593  |  
|Payments                    |  |                                         | (2,264 | ) |                        |   | (78   | )     |  |   | (294  | ) |  |   | (2,636 | )
|                            |  |                                         |        |   |                        |   |       |       |  |   |       |   |  |   |        |  
|Balance, September 30, 2008 |  | $                                       | 1,006  |   |                        | $ | 3,102 |       |  | $ |      |   |  | $ | 4,108  |  
|                            |  |                                         |        |   |                        |   |       |       |  |   |       |   |  |   |        |  

Note 11  Net Operating Loss Carryforwards

At December 31, 2007, we had available net operating loss carryforwards for federal and state income tax reporting purposes of approximately $176.5
million and $33.1 million, respectively, and had available tax credits of approximately $7.6 million, which are available to offset future taxable income. A portion of these carryforwards will expire in 2008, and will continue to expire through 2027
if not otherwise utilized. Our ability to use such net operating losses and tax credit carryforwards is subject to an annual limitation due to change of control provisions under Sections 382 and 383 of the Internal Revenue Code. An additional change
of control as defined by such provisions may have resulted from our registered direct offering dated April 25, 2008, and, if so, the limitation on the usage of our net operating losses and tax credit carryforwards in the future would be
significant.

Note 12  Subsequent Events through November 12, 2008

Ribotask ApS.In October 2008, we announced that we had acquired IP related to non-nucleotide chemistry from Ribotask ApS, a privately held Danish
company specializing in the development and synthesis of novel RNA chemistries. We believe that the technology will permit us to stabilize and provide drug-like properties to RISC and Dicer-length siRNAs in a novel and proprietary manner.

Severance. In October 2008, we announced the termination of employment of our Chief Scientific Officer, effective November 30,
2008. In connection with the termination, we incurred a severance liability of approximately $1.7 million which will be paid on or before June 30, 2009. In addition, as of November 30, 2008, 42,000 remaining unvested restricted shares will
become fully vested and unvested options to purchase 1,700,000 shares of common stock at a weighted average exercise price of approximately $2.84 per share that had been previously granted pursuant to his employment agreement will become fully
vested and exercisable. Additional unvested options to purchase 2,831 shares of common stock at an exercise price of $13.16 per share will also become fully vested and exercisable in accordance with the terms of his employment agreement. The former
executive also agreed to surrender, without consideration, for cancellation, options to purchase up to an aggregate of 700,000 shares of common stock, namely options to purchase up to 600,000 shares of common stock at an exercise price of $14.72 per
share and options to purchase up to 100,000 shares of common stock at an exercise price of $25.00 per share, effective October 28, 2008. In connection with the termination, we expect to recognize approximately $2.9 million in non-cash
stock-based compensation expense in the fourth quarter of 2008, of which $2.5 million relates to the acceleration of vesting of unvested options and awards under the terms of the agreement.

New Chief Scientific Officer. In October 2008, we announced that we had hired a new Chief Scientific Officer, effective January 2, 2009. In
connection with the terms of the new Chief Scientific Officers employment agreement, we will grant options to purchase up to 360,000 shares of common stock at an exercise price to be determined on the date of grant which will be
January 2, 2009.



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ITEM 2  MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
RESULTS OF OPERATIONS

Overview

Statements contained herein that are not historical fact may be forward-looking statements within the meaning of Section 27A of the Securities Act, and Section 21E of the Exchange Act, that are subject to a variety of risks and
uncertainties. There are a number of important factors that could cause actual results to differ materially from those projected or suggested in any forward-looking statement made by us. These factors include, but are not limited to: (i) the
ability of our company to obtain additional funding; (ii) the ability of our company to attract and/or maintain manufacturing, research, development and commercialization partners; (iii) the ability of our company and/or a partner to
successfully complete product research and development, including pre-clinical and clinical studies and commercialization; (iv) the ability of our company and/or a partner to obtain required governmental approvals, including product and patent
approvals; and (v) the ability of our company and/or a partner to develop and commercialize products that can compete favorably with those of competitors. In addition, significant fluctuations in quarterly results may occur as a result of the
timing of milestone payments, the recognition of revenue from milestone payments and other sources not related to product sales to third parties, and the timing of costs and expenses related to our research and development programs. Additional
factors that would cause actual results to differ materially from those projected or suggested in any forward-looking statements are contained in our filings with the Securities and Exchange Commission, including those factors discussed under the
captions Forward-Looking Information and Risk Factors in our most recent Annual Report on Form 10-K, as may be supplemented or amended by our Quarterly Reports on Form 10-Q, which we urge investors to consider. We undertake
no obligation to publicly release revisions in such forward-looking statements that may be made to reflect events or circumstances after the date hereof or to reflect the occurrences of unanticipated events or circumstances, except as otherwise
required by securities and other applicable laws.

Overview

We are a biotechnology company focused on the development and commercialization of pharmaceuticals based on RNA interference (RNAi). Our goal is to improve human health through the development of
RNAi-based compounds that provide superior therapeutic options for patients. Our team of over 30 scientists with expertise in the discovery, evaluation and optimization of small interfering RNAs (siRNAs) and delivery technologies have
the requisite experience in the areas of RNAi, molecular and cellular biology, lipid and peptide chemistry, pharmacology and bioinformatics necessary to discover and develop tailored RNAi-based compounds designed to elicit specific therapeutic
effects on a target-by-target basis. Our infrastructure provides for pre-clinical scale manufacturing of siRNAs and delivery materials, the comprehensive analysis and optimization of these compounds both individually and as drug candidates, and the
filing of Investigational New Drug Applications. In addition to our own, internally-developed technologies, we strategically in-license and further develop RNAi- and delivery-related technologies, forming a single integrated drug discovery platform
that will be the engine for our clinical pipeline as well as a versatile platform for establishing broad therapeutic partnerships with biotechnology and pharmaceutical companies. In order to protect our innovations that now encompass a broad
platform of both RNAi and delivery technologies, and the eventual drug products that emerge from that platform, we will continue to aggressively build upon our extensive and enabling intellectual property (IP) estate.

By combining broad and proven expertise in RNAi science and delivery platforms, a strong IP position, and a pre-clinical pipeline in key therapeutic
areas including oncology, metabolic disorders and inflammation, we have established ourselves as a leading RNAi-based therapeutics company. Our history has been based on nasal delivery; however, our current efforts are almost exclusively devoted to
our RNAi programs, and our name has changed from Nastech Pharmaceutical Company Inc. to MDRNA, Inc. We continue to work to identify a partner or partners to further develop and commercialize our legacy intranasal programs through either a sale or
licensing transaction; however, there can be no assurance that we will be able to identify suitable partners for our intranasal programs or a sale or licensing transaction on terms acceptable to us or at all.

Commencing in the fourth quarter of 2007 and continuing in the first nine months of 2008, we implemented plans to restructure operations to concentrate
resources on key programs, and we continue to focus on maximizing the performance of our business and controlling costs to respond to the economic environment. In connection with these operational changes, we suspended further clinical development
of our intranasal programs. We have reduced our workforce from approximately 235 employees in late 2007 to approximately 58 employees as of September 30, 2008, including approximately six full-time-equivalents maintaining our manufacturing,
quality assurance and quality control operations in support of our current partnerships. Our business model now centers on continuation of research and development (R&D) activities focused on



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RNAi. We will also continue to manufacture Nascobal® spray under our agreement with QOL Medical,
LLC (QOL). There can be no assurance that our focus on these programs will produce acceptable results. If we are not successful in implementing or operating under this new business model, our stock price will suffer. Moreover, any other
future changes to our business may not prove successful in the short or long term due to a variety of factors, including competition, success of research efforts or our ability to partner our product candidates, and may have a material impact on our
financial results.

RNAi

We are
developing novel technologies and therapeutics based on RNAi to down-regulate the expression of certain disease-causing proteins that are over-expressed in inflammation, cancer and other diseases. Therapeutics based on RNAi work through a
naturally-occurring process within cells that has the effect of reducing levels of genetic material (messenger RNA) required for the production of proteins. RNAi is not gene therapy, but instead targets messenger RNA that is downstream of DNA.
Nevertheless, RNAi enables the targeting of disease at a genetic level, and thus with very high specificity. The Nobel Prize-winning discovery of RNAi has led to its wide use in the research of biological mechanisms and target validation. It is
recognized as having tremendous potential in its own right for use as a pharmaceutical. We have created novel RNAi structures for targeting specific diseases and have a variety of proprietary delivery platforms and technologies to enable a range of
development programs spanning multiple therapeutic areas. Our current programs and technologies continue to demonstrate significant progress in pursuing therapeutic indications such as oncology, infectious diseases, metabolic dysfunction, and
inflammation-associated disorders. Our current technologies have shown impressive pre-clinical efficacy and a clear potential for commercial application in systemic and local delivery. We intend to expand on those pre-clinical successes as we move
toward early clinical studies as appropriate, and increase the breadth and capabilities of our infrastructure and platform including our second-generation technologies in both siRNAs and delivery. Our business model anticipates that the expansion
and advancement of a therapeutic pipeline will bring proof of concept for our siRNA and delivery technologies and corporate capabilities, and bring value for shareholders through licensing activities and therapeutic development collaborations with
potential partners.

Platform Technologies

We are making advancements in both of the areas crucial to superior RNAi therapeutics, the active drug, siRNA, and the delivery component that is proving to be the biggest technical challenge in bringing RNAi-based
drugs to the clinic and eventually to the market in broad application.

siRNA. Our most advanced siRNA platform is a Dicer substrate
(D-siRNA). Our D-siRNA is a duplex of two strands of RNA of differing lengths, one of 25 nucleotides (25-mer), the other a 27-mer. These duplexes are intentionally made longer so that they enter the RNAi pathway earlier than
the traditional RNA Induced Silencing Complex (RISC) substrate. We and others have discovered that the Dicer substrate design can provide higher potency than RISC substrates directed against a given gene. Additionally, the
extra nucleotides provide convenient places of attachment for delivery molecules such as peptides and proteins, without interfering with the enzymatic processes of RNA interference. The Dicer enzyme removes the extra as it prepares the
siRNA for loading into the RISC. The higher potency of D-siRNAs and ease of attaching delivery directly to the active drug can enhance the overall efficacy of an RNAi-based therapeutic product.

Meroduplex is our second-generation siRNA platform, which we invented and developed. It is a three-stranded design, introducing a nick or gap in the
strand of the RNA duplex not intended to be used in RNAi. Meroduplex constructs are showing improved properties over two-stranded constructs in certain safety aspects associated with nucleic acid drugs, with minimal or no changes in potency.

Delivery. Both of our lead candidates for our most advanced programs utilize
a lipid-based delivery technology (liposome), and incorporate a novel and proprietary lipid we call DiLA2. This lipid was designed by our scientists
based on amino acid (e.g., peptide/protein-based) chemistry. A DiLA2-containing liposome has several advantages including chemistry; enabling safe
and natural metabolism by the body, the ability to adjust liposome size, shape, and circulation time, thereby influencing bio-distribution; attachment points for molecules that can influence other delivery-related attributes such as targeting and
cellular uptake. Our siRNA formulations using different members of the DiLA2lipid family have shown safe and effective delivery for both local and
systemic delivery as described further below.

Our second generation delivery emphasizes the use of peptides to provide enhanced delivery,
for example improving cellular uptake, intracellular function, nanoparticle formation and targeting. Ongoing developments include the use of peptide technology exclusively licensed by us from the University of Michigan, to a class of peptides used
in the condensation of siRNA to form compact and potent nanoparticles of siRNA; screening of our proprietary phage display library for targeting and cellular uptake peptides, in collaboration with the University of Helsinki; internal
discovery and development of peptides



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or other compounds recognized as having targeting or cellular uptake properties. Our goal in the use of such technologies is to decrease the amount of final
drug required to produce the same effect, both by potentiating the drug product as well as directing more of the final drug dose to the intended site of action.

Our most advanced RNA program has demonstrated efficacy in animal models against multiple influenza strains, including avian influenza (H5N1). Since the influenza virus has a demonstrated ability to develop mutations
in its genetic sequence that allow it to acquire drug resistance to current therapies, or to infect other hosts, e.g., avian influenza to infect humans. Our approach is to target highly conserved regions across all known human strains as well as
identified avian strains. siRNA therapeutic targeting sequences that are highly conserved are broadly active across strains and may be less likely to mutate. The ability to target across all flu genomes, including avian and others having pandemic
potential, may provide a solution to this treatment of pathogenic influenza. We believe our lead candidate represents a viable approach to fighting a pandemic influenza outbreak and is one of the most advanced anti-influenza compounds based on RNAi.
Our lead candidate can be administered by inhalation to maximize delivery to lung and has the potential to be delivered to the nasal cavity to prevent or abate early viral infections. The product is being designed for ease of use by patients and for
long-term stability, both of which are essential for stockpiling the product for rapid mobilization and immediate use during an influenza epidemic or a more concerning pandemic. We are currently seeking a partner in the biodefense sector to advance
this program.

We are working on a number of pre-clinical siRNA programs including the following:



| |  |  | Metabolic disorders. We identified a lead siRNA candidate for Apolipoprotein B (ApoB) in the third
quarter of 2008. ApoB is a protein used by the body for transport of cholesterol, in particular LDL cholesterol, which has been proposed as a major underlying factor in cardiovascular disease secondary to hypercholesterolemia. ApoB is synthesized in
the liver and parts of the small intestine. We have pre-clinical data demonstrating the efficacy of our lead siRNA candidate formulated in our proprietary DiLA2 based liposome. Our studies to date have demonstrated that administration of formulated siRNA results in substantial and specific reduction in levels of ApoB messenger RNA in both liver and jejunum and
decreased cholesterol levels in blood.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Oncology.We are pursuing RNAi-based treatments for bladder cancer and lung cancer. Bladder cancer is the fifth most common cancer in the U.S. with 67,000
new cases each year. It is the seventh most common cancer in the world, including 120,000 new cases each year in Europe. The National Cancer Institute estimates that in 2008, lung cancer will be diagnosed in over 200,000 individuals in the U.S. and
over 160,000 lung cancer patients will die from their illness. Current treatments for these cancers include repeated surgeries or even removal of all or part of the involved organ for some patients. The prognosis for lung cancer patients is
particularly poor as the overall five-year survival rate for lung cancer is approximately 15 percent. We are currently evaluating panels of siRNAs against several gene targets for our programs in both bladder and lung cancer. For bladder cancer we
have identified highly potent siRNA lead candidates. We intend to begin pre-IND studies in early 2009.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Inflammation. We have screened numerous siRNA candidates targeting human TNF-alpha in cells derived from normal human donors. siRNAs that showed the highest
potency were optimized for chemical stability and favorable pharmacological and safety properties. In collaboration with the Mayo Clinic, knock-down of TNF-alpha was verified in cells from patients with active rheumatoid arthritis. Additional
pre-clinical activities are continuing.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We will continue to focus our R&D efforts on RNAi-based therapeutics, and
continue to develop and acquire our RNAi technologies and IP estate.

As of November 5, 2008, we had, either through ownership of or
access to, through exclusive licenses, four issued patents and 304 pending patent applications to protect our RNAi proprietary technologies.

RNAi
Intellectual Property and Contractual Agreements

A major part of our business strategy is to enter into collaborations and
strategic partnerships with pharmaceutical companies and biotechnology companies, academic institutions, research foundations and others, as appropriate, to gain access to funding, technical resources and IP to further our development efforts and to
generate revenue.

City of Hope. In November 2006, we entered into a license with the Beckman Research Institute/City of Hope
for exclusive and non-exclusive licenses to the Dicer-substrate RNAi IP developed there. City of Hope granted non-exclusive rights under the licensed patent applications for the treatment of all human diseases, less certain infectious diseases, as
well as exclusive rights to five named respiratory viral targets. Our rights under the licenses, including sub-licensing, are subject to certain limitations. We believe these limitations will have no impact on our programs. This IP and technology
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provide significant commercial and therapeutic advantages for us in this field by enabling the use of 25 to 30 base pair RNA duplexes designed to act as
substrates for processing by the cells natural activities. The slightly larger Dicer substrates provide attachment points for delivery-enabling molecules, thereby potentially enhancing the overall efficacy of an RNAi-based therapeutic product.

University of Michigan. In May 2008, we entered into an exclusive license
agreement to IP from the University of Michigan covering cationic peptides for enhanced delivery of nucleic acids. These peptides have unique characteristics that we believe play an important role in improving the efficacy of delivery of RNAi-based
therapeutics. We are currently using these peptides to create siRNA nanoparticles to enhance gene expression knockdown. Together with the DiLA2platform of novel delivery lipids, these delivery peptides improve the therapeutic potential of our drug candidates.

University of Helsinki. In June 2008, we entered into a collaboration with Dr. Pirjo
Laakkonen and the Biomedicum Helsinki to screen our patented phage display library, the Trp Cage library. The goal of the work is to discover and evaluate peptides for their potential to be incorporated into our siRNA formulations to contribute to
targeting particular tissues or organs indicated in a given disease. We expect to use the peptides to improve and increase the delivery options for siRNA, including nanoparticle technology and the combination of novel peptides with our
DiLA2platform.

Université
Laval (Quebec). We are collaborating with Université Laval in the area of therapeutic siRNAs against pulmonary viruses including respiratory syncytial virus (RSV) and human metapneumovirus.

Ribotask ApS.In October 2008, we announced that we had acquired IP related to non-nucleotide chemistry from Ribotask ApS, a privately held Danish
company specializing in the development and synthesis of novel RNA chemistries. We believe that the technology will permit us to stabilize and provide drug-like properties to RISC and Dicer-length siRNAs in a novel and proprietary manner.

Government Grants.In September 2006, the National Institutes of Health, or NIH, awarded us a $1.9 million grant over a five year
period to prevent and treat influenza. Revenue recognized under this grant totaled $0.1 million for both the three month periods ended September 30, 2007 and 2008. Revenue recognized under this grant totaled $0.3 million for the nine month
period ended September 30, 2007 and $0.2 million for the nine month period ended September 30, 2008.

Intranasal Programs

As previously discussed, we continue to work to identify a partner or partners to further develop and commercialize our legacy
intranasal programs through either a sale or licensing transaction; however, there can be no assurance that we will be able to identify suitable partners for our intranasal programs or a sale or licensing transaction on terms acceptable to us or at
all.

We believe our nasal drug delivery technology offers advantages over injectable routes of administration for large molecules, such as
peptides and proteins. These advantages may include improved safety, clinical efficacy and increased patient compliance, due to the elimination of injection site pain or irritation. In addition, we believe our nasal drug delivery technology can
potentially offer advantages over oral administration by providing for faster absorption into the bloodstream, and improved effectiveness by avoiding problems relating to gastrointestinal side effects and first-pass liver metabolism.

We have engaged in a variety of pre-clinical initiatives, alone and with partners, to explore a range of potential therapeutic applications of our tight
junction technology. Certain of these initiatives included funded feasibility studies in which our tight junction drug delivery technology is combined with already-approved therapeutics, or product candidates currently in development, to determine
if formal pre-clinical trials are warranted. In 2007, we participated in three external feasibility studies with three different partners, including a multi-compound feasibility study with Novo Nordisk with respect to certain undisclosed Novo
Nordisk therapeutic compounds, a Factor IX development program for the treatment of hemophilia with an undisclosed partner and a program with an undisclosed partner to deliver an undisclosed anti-seizure medication. Feasibility studies, typically
lasting approximately one year, allow us to efficiently evaluate opportunities in which our tight junction technology may produce a product that has improved therapeutic and commercial promise. In January 2008, Novo Nordisk A/S (Novo
Nordisk) terminated their feasibility study agreement with us. In the second quarter of 2008, our two feasibility studies with undisclosed partners had been completed.

Through our expertise in tight junction biology, we are developing, or have developed, clinical product candidates in multiple therapeutic areas,
including the following:

Exenatide. Exenatide, marketed by Amylin
Pharmaceuticals, Inc. (Amylin) and Lilly as Byetta®, stimulates insulin secretion in response to elevated plasma glucose levels. In June 2006, we entered into an agreement with
Amylin to develop a nasal spray formulation of the product, for the treatment of type 2 diabetes. Pre-clinical studies and a Phase 1 clinical trial



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have been completed by Amylin and additional clinical trials are being evaluated. Under the terms of the agreement, we will receive both milestone payments
and royalties on product sales. If the development program is successful and the development of this product continues to move forward, milestone payments could reach up to $89 million in total, based on specific development, regulatory and
commercialization goals. Royalty rates escalate with the success of this product. Under the terms of our agreement with Amylin, we will jointly develop the nasal spray formulation with Amylin utilizing our proprietary nasal delivery technology, and
Amylin will reimburse us for any development activities performed under the agreement. Amylin has overall responsibility for the development program, including clinical, non-clinical and regulatory activities and our efforts will focus on drug
delivery and chemistry, manufacturing and controls, or CMC, activities.

Calcitonin. In October 2004, we entered into a license and supply agreement with Par Pharmaceutical Companies, Inc. (Par Pharmaceutical) for the exclusive U.S. distribution and marketing rights to a generic
calcitonin-salmon nasal spray for the treatment of osteoporosis which is pending FDA approval. Under the terms of the agreement, we will manufacture and supply finished calcitonin-salmon nasal spray product to Par Pharmaceutical, while
Par Pharmaceutical will distribute the product in the U.S. The financial terms of the agreement include milestone payments, product transfer payments for manufactured product and profit sharing following commercialization. At
September 30, 2008, the original cost basis of our inventory was approximately $2.7 million, composed of $0.1 million of Nascobal® API and materials, and $2.6 million of
calcitonin-salmon API and materials for our nasal calcitonin-salmon product. Apotex has filed a generic application for its nasal calcitonin-salmon product with a filing date that has priority over our ANDA for our generic nasal calcitonin-salmon
product. In May 2008, the federal district court dismissed the patent infringement lawsuit brought by Novartis against Apotex, due to the parties reaching a settlement in their long-standing litigation. The terms of this settlement were not made
public. This created uncertainty over our ability to launch our nasal calcitonin-salmon product and has caused us to reassess the value of our inventory. In the second quarter of 2008, we recorded a non-cash impairment charge of approximately $2.6
million to cost of goods sold related to the write-down of inventory because we considered the carrying amount of this inventory to likely not be recoverable. It is possible that we may receive partial or full reimbursement under the terms of our
contractual arrangement with Par Pharmaceutical should we not be able to use this material in connection with our manufacturing arrangement, but the amount and timing of any such reimbursement are not determinable at this time.

Other intranasal programs. We have also developed a rapid-acting nasal insulin product that recently completed a Phase 2 clinical trail in
patients with diabetes, a product (Peptide YY(3-36)) for the treatment of obesity, a product (PTH(1-34)) for the treatment of osteoporosis and a product (carbetocin) for the treatment of autism, all of which are on hold pending further funding or
partnering.

Other Agreements

Questcor Pharmaceuticals, Inc./QOL Medical LLC. In February 2005, the FDA approved our
Nascobal® nasal spray 505(b)(2) application for vitamin B12 (cyanocobalamin) deficiency in patients with pernicious anemia, Crohns Disease, HIV/ AIDS and multiple sclerosis. We
developed the Nascobal® nasal spray as an alternative to Nascobal® (Cyanocobalamin, USP) gel, an FDA-approved product launched in
1997. In October 2005, we received $2.0 million from Questcor Pharmaceuticals Inc. (Questcor) as consideration for our consent to the assignment of the 2003 Questcor Asset Purchase and Supply Agreement (the QOL
Agreement) and in connection with our entering into an agreement with QOL that modified certain terms of the QOL Agreement. Under the terms of the QOL Agreement, subject to certain limitations, we are obligated to manufacture and supply, and
QOL is obligated to purchase from us, all of QOLs requirements for Nascobal® brand products. The $2.0 million is being recognized ratably over the five-year life of the QOL
Agreement. QOL also assumed Questcors obligation to pay us $2.0 million on the issuance by the U.S. Patent and Trademark Office (PTO) of a patent covering any formulation that treats any indication identified in our NDA
for Nascobal® nasal spray. This payment became due and was received and recognized as revenue in the second quarter of 2007. We recognized product revenue relating to the supply agreement
of approximately $0 and $0.2 million in three months ended September 30, 2007 and 2008, respectively, and approximately $0.2 million and $0.9 million in the nine months ended September 30, 2007 and 2008, respectively.

Cytyc Corporation. In July 2003, we entered into a five-year agreement with Cytyc Corporation (Cytyc) pursuant to which Cytyc
acquired patent rights to our Mammary Aspirate Specimen Cytology Test (MASCT) device. Under the terms of the agreement, we received a license fee from Cytyc in 2003 and reimbursement for the cost of patent maintenance and further patent
prosecution if incurred during the term of the agreement. In July 2008, the agreement term lapsed and all rights reverted to us. We intend to surrender the rights to this device to a related party in the fourth quarter of 2008, in consideration of
such partys assumption of all liabilities related to the device.

Liquidity, Going Concern and Capital Resources

We have prepared our consolidated financial statements assuming that we will continue as a going concern, which contemplates realization of assets and the
satisfaction of liabilities in the normal course of business. As of September 30, 2008, we had an accumulated deficit of approximately $241.8 million and expect to incur additional losses in the future as we continue our R&D
activities. We also have negative cash flows, and customers representing a majority of our 2007 revenue have terminated their contractual agreements with us. We have funded our losses primarily through the sale of common stock



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and warrants in the public markets and private placements, revenue provided by our collaboration partners and, to a lesser extent, equipment financing
facilities. The further development of our RNAi programs will require significant capital. At September 30, 2008, we had working capital (current assets less current liabilities) of $1.5 million and approximately $10.9 million in cash and cash
equivalents, including $2.2 million in restricted cash. While we continue to implement cost containment efforts, our operating expenses, primarily R&D, will consume a material amount of our cash resources.

On January 22, 2008, we filed a universal shelf registration statement with the Securities and Exchange Commission (SEC) pursuant to
which we can issue up to $50.0 million of our common stock, preferred stock, debt securities, warrants to purchase any of the foregoing securities and units comprised of any of the foregoing securities. The universal shelf registration
statement was declared effective by the SEC on February 4, 2008. However, our ability to raise capital using our effective shelf registration statements may be limited for so long as the public float of our common stock remains below $75
million.

On April 25, 2008, we raised net proceeds of approximately $7.3 million in a registered direct offering of 4,590,277 shares
of common stock along with warrants to purchase up to 5,967,361 shares of common stock at a negotiated purchase price of $1.728 per share. Warrants to purchase up to 4,590,277 shares of common stock are exercisable during the seven-year period
beginning October 25, 2008 at a price of $2.376 per share, and warrants to purchase up to 1,377,084 shares of common stock are exercisable during the 90-day period beginning October 25, 2008 at a price of $2.17 per share. In addition,
warrants to purchase up to 229,514 shares of common stock, which are exercisable during the five-year period beginning October 25, 2008 at a price of $2.376 per share, were issued to the placement agent in connection with the transaction.

We believe that our current resources are sufficient to fund our planned operations into the first quarter of 2009. We based our estimate
on our ability to perform planned R&D activities, the receipt of planned funding and proceeds from assets held for sale. Our recent decline in market valuation and volatility in our stock price, as well as global market conditions, could make it
difficult for us to raise capital on favorable terms, or at all. Any financing we obtain may further dilute or otherwise impair the ownership interest of our current stockholders. If we fail to generate positive cash flows or fail to obtain
additional capital when required, we could modify, delay or abandon some or all of our programs. These factors, among others, raise substantial doubt about our ability to continue as a going concern. The condensed consolidated financial statements
do not include any adjustments that may result from the outcome of this uncertainty. We received an opinion for the year ended December 31, 2007 from our independent registered accounting firm noting the substantial doubt about our ability to
continue as a going concern due to our significant recurring operating losses and negative cash flows.

On September 19, 2008, we
received a letter from the Listing Qualifications Department of the NASDAQ Stock Market notifying us that we were not in compliance with the minimum $1.00 per share minimum bid price requirement for continued inclusion on the NASDAQ Global Market
set forth in NASDAQ Marketplace Rule 4450(a)(5), as a result of the bid price of our common stock having closed below $1.00 for the last 30 consecutive business days prior to the date of the letter. NASDAQs letter advised us that, in
accordance with the NASDAQ Marketplace Rule 4450(e)(2), we will be provided 180 calendar days, or until March 18, 2009, to regain compliance. The letter further advises that such compliance can be achieved if, at any time before March 18,
2009, the bid price of our common stock closes at $1.00 or more per share for a minimum of 10 consecutive business days. On October 16, 2008, NASDAQ suspended enforcement of the minimum bid price requirement through January 19, 2009, and
accordingly, our date to regain compliance with the continued listing requirement of NASDAQ Marketplace Rule 4450(a)(5) has been extended to June 22, 2009. There can be no assurance that we will be able to regain compliance with the continued
listing requirement of NASDAQ Marketplace Rule 4450(a)(5).

During the fourth quarter of 2007 and continuing in the first nine months of
2008, we implemented cost containment efforts and we continue to focus on maximizing the performance of our business and controlling costs to respond to the economic environment and will continue to evaluate our underlying cost structure to improve
our operating results and better position ourselves for growth. As such, we may incur further restructuring charges, including severance, benefits and related costs due to a reduction in workforce and/or charges for facilities consolidation or for
assets disposed of or removed from operations as a direct result of a reduction of workforce. We will continue to experience losses and negative cash flows in the near term, even if revenue related to collaborative partnerships grows.

We used cash of $34.4 million in our operating activities in the first nine months of 2008, compared to $31.6 million in the first nine months of 2007.
Cash used in operating activities relates primarily to funding net losses and changes in deferred revenue from collaborators, accounts and other receivables, accounts payable and accrued expenses and other liabilities,



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partially offset by depreciation and amortization, non-cash charges related to restructuring and write-down of inventory and non-cash compensation related to
restricted stock, stock options and our employee stock purchase plan. In the nine month period ended September 2008, cash payments for severance, benefits and related costs due to our workforce reductions totaled approximately $2.3 million. We
expect to continue to use cash for operating activities in the foreseeable future as we continue our R&D activities.

Our investing
activities provided cash of $12.2 million in the first nine months of 2008, compared to $2.2 million in the first nine months of 2007. Changes in cash from investing activities are due primarily to maturities of investments net of purchases,
purchases of property and equipment and proceeds from sales of property and equipment. We have pledged approximately $2.2 million of our cash as collateral for letters of credit for leased facilities.

Our financing activities provided cash of $3.2 million in the first nine months of 2008 compared to $42.2 million in the first nine months of 2007.
Changes in cash from financing activities are primarily due to issuance of common stock and warrants, borrowings and repayment of equipment financing facilities and proceeds from exercises of stock options and employee stock purchase plan purchases.
We raised net proceeds of approximately $40.9 million in January 2007 through public placement of shares of our common stock and approximately $7.3 million in April 2008 through a registered direct offering of shares of our common stock and
warrants.

Critical Accounting Policies and Estimates

We prepare our consolidated financial statements in conformity with accounting principles generally accepted in the U.S. As such, we are required to make certain estimates, judgments and assumptions that we believe
are reasonable based upon the information available. These estimates and assumptions affect the reported amounts of assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenue and expenses during
the periods presented. Actual results could differ significantly from those estimates under different assumptions and conditions. We believe that the following discussion addresses our most critical accounting estimates, which are those that we
believe are most important to the portrayal of our financial condition and results of operations and which require our most difficult and subjective judgments, often as a result of the need to make estimates about the effect of matters that are
inherently uncertain. Other key estimates and assumptions that affect reported amounts and disclosures include depreciation and amortization, inventory reserves, asset impairments, restructuring accruals, requirements for and computation of
allowances for doubtful accounts, allowances for product returns and expense accruals. We also have other policies that we consider key accounting policies; however, these policies do not meet the definition of critical accounting estimates because
they do not generally require us to make estimates or judgments that are difficult or subjective.

Revenue Recognition

Our revenue recognition policies are based on the requirements of SEC Staff Accounting Bulletin (SAB) No. 104 Revenue Recognition, the
provisions of Emerging Issues Task Force (EITF) Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, (EITF 00-21) and the guidance set forth in EITF Issue No. 01-14, Income Statement
Characterization of Reimbursements Received for Out-of-Pocket Expenses Incurred (EITF 01-14). Revenue is recognized when there is persuasive evidence that an arrangement exists, delivery has occurred, collectibility is
reasonably assured, and fees are fixed or determinable. Deferred revenue expected to be realized within the next 12 months is classified as current.

Substantially all of our revenues are generated from research and licensing arrangements with partners that may involve multiple deliverables. For multiple-deliverable arrangements, judgment is required to evaluate,
using the framework outlined in EITF 00-21, whether (a) an arrangement involving multiple deliverables contains more than one unit of accounting, and (b) how the arrangement consideration should be measured and allocated to the
separate units of accounting in the arrangement. Our research and licensing arrangements may include upfront non-refundable payments, development milestone payments, payments for contract R&D services performed, patent-based or product sale
royalties, government grants, and product sales. For each separate unit of accounting, we have determined that the delivered item has value to the customer on a stand-alone basis, we have objective and reliable evidence of fair value using available
internal evidence for the undelivered item(s) and our arrangements generally do not contain a general right of return relative to the delivered item. In accordance with the guidance in EITF 00-21, we use the residual method to allocate the
arrangement consideration when we do not have an objective fair value for a delivered item. Under the residual method, the amount of consideration allocated to the delivered item equals the total arrangement consideration less the aggregate fair
value of the undelivered items.

Revenue from research and licensing arrangements is recorded when earned based on the performance
requirements of the contract. Nonrefundable upfront technology license fees for product candidates where we are providing continuing services related to product development are deferred and recognized as revenue over the development period or as we
provide the services required under the agreement. The ability to estimate total development effort and costs can vary



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significantly for each product candidate due to the inherent complexities and uncertainties of drug development. The timing and amount of revenue that we
recognize from upfront fees for licenses of technology is dependent upon our estimates of filing dates or development costs. Our typical estimated development periods run two to six years, with shorter or longer periods possible. The estimated
development periods are based upon structured detailed project plans completed by our project managers, who meet with scientists and collaborative counterparts on a regular basis and schedule the key project activities and resources including
headcount, facilities and equipment, budgets and clinical studies. The estimated development periods generally end on projected filing dates with the FDA for marketing approval. As product candidates move through the development process, it is
necessary to revise these estimates to consider changes to the product development cycle, such as changes in the clinical development plan, regulatory requirements, or various other factors, many of which may be outside of our control. The impact on
revenue of changes in our estimates and the timing thereof is recognized prospectively over the remaining estimated product development period.

During 2007, we recognized revenue over the estimated development period for a $10.0 million license fee received in early 2006 from Procter & Gamble Pharmaceuticals, Inc. (P&G). As noted above, we adjust the
period on a prospective basis when changes in circumstances indicate a significant increase or decrease in the estimated development period has occurred. For example, our P&G collaboration agreement was amended in December 2006 and we reviewed
the estimated development period at that time. Since additional clinical studies were added to the project plan, the estimated development period was lengthened and the portion of the initial $10.0 million recognized each period as revenue was
adjusted on a prospective basis to reflect the longer period.

In the fourth quarter of 2007, our collaboration agreement with P&G was
terminated. Accordingly, the estimated development period over which we were recognizing the $10.0 million license fee received in early 2006 ended at that time, and the remaining unrecognized portion, approximately $5.5 million, was fully
recognized in the fourth quarter of 2007.

We do not disclose the exact development period for competitive reasons and due to
confidentiality clauses in our contracts. As an illustrative example only, a one-year increase in a three-year estimated development period to four years, occurring at the end of year one, for a $10.0 million license fee would reduce the annual
revenue recognized from approximately $3.3 million in the first year to approximately $2.2 million in each of the remaining three years. Other factors we consider that could impact the estimated development period include FDA actions,
clinical trial delays due to difficulties in patient enrollment, delays in the availability of supplies, personnel or facility constraints or changes in direction from our collaborative partners. It is not possible to predict future changes in these
elements.

Milestone payments typically represent nonrefundable payments to be received in conjunction with the achievement of a specific
event identified in the contract, such as initiation or completion of specified clinical development activities. We believe a milestone payment represents the culmination of a distinct earnings process when it is not associated with ongoing
research, development or other performance on our part and it is substantive in nature. We recognize such milestone payments as revenue when they become due and collection is reasonably assured. When a milestone payment does not represent the
culmination of a distinct earnings process, revenue is either recognized when the earnings process is deemed to be complete or in a manner similar to that of an upfront technology license fee.

Revenue from contract R&D services performed is generally received for services performed under collaboration agreements and is recognized as
services are performed. Payments received in excess of amounts earned are recorded as deferred revenue. Under the guidance of EITF 01-14, reimbursements received for direct out-of-pocket expenses related to contract R&D costs are recorded
as revenue in the consolidated statements of operations rather than as a reduction in expenses. Reimbursements received for direct out-of-pocket expenses related to contract R&D for the three and nine months ended September 30, 2007 and
2008 were not material.

Royalty revenue is generally recognized at the time of product sale by the licensee.

Government grant revenue is recognized during the period qualifying expenses are incurred for the research that is performed as set forth under the terms
of the grant award agreements, and when there is reasonable assurance that we will comply with the terms of the grant and that the grant will be received.

Product revenue is recognized when the manufactured goods are shipped to the purchaser and title has transferred under our contracts where there is no right of return. Provision for potential product returns has been
made on a historical trends basis. To date, we have not experienced any significant returns from our customers.



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Research and Development Costs

All R&D costs are charged to operations as incurred. Our R&D expenses consist of costs incurred for internal and external R&D and include
direct and research-related overhead expenses. We recognize clinical trial expenses, which are included in R&D expenses, based on a variety of factors, including actual and estimated labor hours, clinical site initiation activities, patient
enrollment rates, estimates of external costs and other activity-based factors. We believe this method best approximates the efforts expended on a clinical trial with the expenses recorded. We adjust our rate of clinical expense recognition if
actual results differ from our estimates.

The ability to estimate total development effort and costs can vary significantly for each
product candidate due to the inherent complexities and uncertainties of drug development.

Stock-Based Compensation

We use the Black-Scholes option pricing model as our method of valuation for stock-based awards. Stock-based compensation expense for employees and
non-employee directors is based on the value of the portion of the stock-based award that will vest during the period, adjusted for expected forfeitures. Our determination of the fair value of stock-based awards on the date of grant using an option
pricing model is affected by our stock price as well as assumptions regarding a number of highly complex and subjective variables. These variables include, but are not limited to, the expected life of the award, expected stock price volatility over
the term of the award and historical and projected exercise behaviors. The estimation of stock-based awards that will ultimately vest requires judgment, and to the extent actual or updated results differ from our current estimates, such amounts will
be recorded in the period estimates are revised. Although the fair value of stock-based awards is determined in accordance with SFAS No. 123R (revised 2004) Share-Based Payment, (SFAS 123R), Staff Accounting Bulletin
No. 107, Share Based Payment and Staff Accounting Bulletin No. 110, Year-End Help for Expensing Employee Stock Options (SAB 110), the Black-Scholes option pricing model requires the input of highly
subjective assumptions, and other reasonable assumptions could provide differing results.

During the three month period ended
September 30, 2008, 5,500 options were granted, at a weighted average price of $0.60 and weighted average fair value of $0.40 as determined by the Black Scholes option pricing model, and if expected term or expected stock volatility for the
options granted during the three month period ended September 30, 2008 increased or decreased by 10% (all other variables held constant) the impact on our reported net loss would not have been material.

Non-cash compensation expense is recognized on a straight-line basis over the applicable vesting periods of one to five years based on the fair value of
such stock-based awards on the grant date. We anticipate expected term and estimated volatility will remain within the ranges listed above in the near term, however, unanticipated business or other conditions may change which could result in
differing future results.

In June 2008 we granted stock options to four non-employee members of our Scientific Advisory Board. For stock
options granted as consideration for services rendered by non-employees, we recognize compensation expense in accordance with the requirements of SFAS 123(R), EITF Issue No. 96-18, Accounting for Equity Instruments that are Issued to
Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or Services and EITF Issue No. 00-18 Accounting Recognition for Certain Transactions involving Equity Instruments Granted to Other Than Employees, as
amended. Non-employee option grants are recorded as an expense over the vesting period of the underlying stock options. At the end of each financial reporting period prior to vesting, the value of these options, as calculated using the Black-Scholes
option pricing model, will be re-measured using the fair value of our common stock and the non-cash compensation recognized during the period will be adjusted accordingly. Since the fair value of options granted to non-employees is subject to change
in the future, the amount of the future compensation expense will include fair value re-measurements until the stock options are fully vested. During the three and nine month periods ended September 30, 2008, we recognized expense of
approximately $14,000 and $52,000, respectively, relating to options granted to non-employee members of our Scientific Advisory Board.

Impairment of
Long-Lived Assets, Assets Held for Sale and Inventory Reserve

Long-lived assets, such as property, equipment and inventory, are
reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable, in accordance with Statement of Financial Accounting Standards (SFAS) No. 144,
Accounting for the Impairment or Disposal of Long-Lived Assets (SFAS 144). Conditions that would necessitate an impairment include a significant decline in the observable market value of an asset, a significant change in the
extent or manner in which an asset is used, or any other significant adverse change that would indicate that the carrying amount of an asset or group of assets is not recoverable. Recoverability of assets to be held and used is measured by a
comparison of the carrying amount of an asset to estimated undiscounted future cash flows expected to be generated by the asset. If the carrying amount of an asset exceeds its estimated future cash flows, an impairment charge is recognized in the
amount by which the carrying amount of the asset exceeds the fair value of the asset. Long-lived assets are considered held for sale when certain criteria are met, including whether management has committed to a plan to sell the asset, whether the
asset is available for sale in its immediate condition, and whether the sale is probable within one year of the reporting date.



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Estimated Accrued Restructuring Charges Related to Facility Consolidation

We follow the provisions of SFAS No. 146, Accounting for Costs Associated with Exit or Disposal Activities (SFAS 146), as it
relates to our facility at 3450 Monte Villa Parkway, Bothell, Washington (3450 Monte Villa), which we have exited as of September 30, 2008. We have recorded an accrued restructuring liability, representing remaining lease payments
due under the lease and other costs, reduced by sublease rental income that could be reasonably obtained from the property, and discounted using a credit-adjusted risk-free interest rate. We used a credit-adjusted risk-free interest rate of 15%, and
we based our sublease expectations on current rental rates available in the Bothell real estate market, our evaluation of our ability to sublease our facility in light of tightening credit markets, deteriorating conditions in the Bothell real estate
market and increased vacancy rates in the competing downtown real estate markets. Payment of rent related to this facility is reflected as a reduction in the amount of the accrued restructuring liability. We will recognize accretion expense due to
the passage of time as an additional restructuring charge. Accrued restructuring, and in particular those charges associated with exiting a facility, are subject to managements assumptions and estimates. In addition to the interest rate used,
the assumptions as to estimated sublease rental income, the period of time to execute a sublease and the costs and concessions necessary to enter into a sublease significantly impact the accrual and actual results may differ from our estimates.

Income Taxes

Income taxes are
accounted for under the asset and liability method. Deferred tax assets and liabilities are recognized for the future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities
and their respective tax bases and operating loss and tax credit carry-forwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are
expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. We continue to record a valuation allowance for the full amount
of deferred tax assets since realization of such tax benefits is not considered to be more likely than not.

Recently Issued Accounting Standards

Effective January 1, 2008, we adopted SFAS No. 157, Fair Value Measurements (SFAS 157), for financial
assets and liabilities. This standard defines fair value, provides guidance for measuring fair value and requires certain disclosures. This standard does not require any new fair value measurements, but rather applies to all other accounting
pronouncements that require or permit fair value measurements and does not apply measurements related to share-based payments. SFAS 157 discusses valuation techniques, such as the market approach (comparable market prices), the income approach
(present value of future income or cash flow), and the cost approach (cost to replace the service capacity of an asset or replacement cost). The statement utilizes a fair value hierarchy that prioritizes the inputs to valuation techniques used to
measure fair value into three broad levels. The following is a brief description of those three levels:

Level 1: Observable inputs such as quoted
prices (unadjusted) in active markets for identical assets or liabilities.

Level 2: Inputs other than quoted prices that are observable for the
asset or liability, either directly or indirectly. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active.

Level 3: Unobservable inputs that reflect the reporting entitys own assumptions.

Our financial assets subject to fair value measurements and the necessary disclosures are as follows (amounts in thousands):



|                          |  |                    |        |                                                                         |   |         |  |         |   |  |   |  
|------------------------- |  | ------------------ | ------ | ----------------------------------------------------------------------- | - | ------- |  | ------- | - |  | - | -
|                          |  | Fair Value at      |        | Fair value Measurements at September 30, 2008using Fair Value Hierarchy
|                          |  | September 30, 2008 |        | Level 1                                                                 |   | Level 2 |  | Level 3
|Cash and cash equivalents |  | $                  | 8,719  |                                                                         | $ | 8,719   |  | $       |  |  | $ | 
|Restricted cash           |  |                    | 2,155  |                                                                         |   | 2,155   |  |         |  |  |   | 
|Short-term investments    |  |                    |       |                                                                         |   |        |  |         |  |  |   | 
|                          |  |                    |        |                                                                         |   |         |  |         |   |  |   |  
|Total                     |  | $                  | 10,874 |                                                                         | $ | 10,874  |  | $       |  |  | $ | 
|                          |  |                    |        |                                                                         |   |         |  |         |   |  |   |  

In February 2008, the Financial Accounting Standards Board, or FASB, issued FASB Staff Position
No. FAS 157-2, Effective Date of FASB Statement No. 157, which provides a one year deferral of the effective date of SFAS 157 for non-financial assets and non-financial liabilities, except those that are recognized or disclosed in
the financial statements at fair value at least annually. Therefore, we adopted the provisions of SFAS 157 with respect to our financial assets and liabilities only.



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In June 2007, the FASB ratified the consensus reached in EITF Issue No. 07-03, Accounting for
Nonrefundable Advance Payments for Goods or Services Received for Use in Future Research and Development Activities (EITF 07-03). EITF 07-03 provides that nonrefundable advance payments for goods or services that will be
used or provided for future R&D activities should be deferred and capitalized and that such amounts should be recognized as an expense as the related goods are delivered or the related services are performed, and provides guidance with respect
to evaluation of the expectation of goods to be received or services to be provided. We adopted the provisions of EITF 07-03 effective January 1, 2008. The adoption of EITF 07-03 did not have a significant impact on our consolidated
financial position or results of operations.

In December 2007, the FASB issued SFAS No. 141(Revised 2007), Business
Combinations (SFAS 141R), which replaces SFAS 141, while retaining the fundamental requirements in SFAS 141 that the acquisition method of accounting be used for all business combinations and that an acquirer be
identified for each business combination. SFAS 141R changes how business acquisitions are accounted for and establishes principles and requirements for how an acquirer recognizes and measures in its financial statements the identifiable assets
acquired, the liabilities assumed, any non-controlling interest in the acquiree and the goodwill acquired both on the acquisition date and in subsequent periods, and also establishes disclosure requirements which will enable users to evaluate the
nature and financial effects of the business combination. SFAS 141R is effective for fiscal years beginning after December 15, 2008. Early adoption is not permitted. The adoption of SFAS 141R will have an impact on future business
combinations.

In December 2007, the FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial
Statements  an amendment of Accounting Research Bulletin No. 51 (SFAS 160). SFAS 160 amends Accounting Research Bulletin No. 51 to establish accounting and reporting standards for the
non-controlling ownership interests in a subsidiary and for the deconsolidation of a subsidiary, and changes the way the consolidated statement of operations is presented by requiring consolidated net income (loss) to be reported at amounts that
include the amounts attributable to both the parent and the non-controlling interest, as well as disclosure, on the face of the statement of operations of those amounts. SFAS 160 also establishes a single method of accounting for changes in a
parents ownership interest in a subsidiary that do not result in deconsolidation, and requires gain recognition in income when a subsidiary is deconsolidated. SFAS 160 also requires expanded disclosures that clearly identify and
distinguish between the interests of the parent and the interests of the non-controlling owners. SFAS 160 is effective for fiscal years beginning after December 15, 2008. In the absence of possible future investments, the adoption of
SFAS 160 will have no effect on our consolidated financial statements.

In December 2007, the FASB ratified the consensuses reached in
EITF Issue No. 07-1, Collaborative Arrangements (EITF 07-1). EITF 07-1 defines collaborative arrangements and establishes reporting requirements for transactions between participants in a collaborative
arrangement and between participants in the arrangements and third parties. Under EITF 07-1, payments between participants pursuant to a collaborative arrangement that are within the scope of other authoritative accounting literature on income
statement classification should be accounted for using the relevant provisions of that literature. If the payments are not within the scope of other authoritative accounting literature, the income statement classification for the payments should be
based on an analogy to authoritative accounting literature or if there is no appropriate analogy, a reasonable, rational, and consistently applied accounting policy election. EITF 07-1 also provides disclosure requirements and is effective for
fiscal years beginning after December 15, 2008, and interim periods within those fiscal years. The effect of applying EITF 07-1 will be reported as a change in accounting principle through retrospective applications to all prior periods
presented for all collaborative arrangements existing as of the effective date, unless it is impracticable. We must adopt EITF 07-1 no later than our first quarter of fiscal 2009. EITF 07-1 will not have an effect on our assets,
liabilities, stockholders equity, cash flows or net results of operations.

In June 2008, the FASB issued SFAS No. 162,
The Hierarchy of Generally Accepted Accounting Principles (SFAS 162). SFAS 162 identifies the sources of generally accepted accounting principles and provides a framework, or hierarchy, for selecting the principles to
be used in preparing U.S. GAAP financial statements for nongovernmental entities, and makes the GAAP hierarchy explicitly and directly applicable to preparers of financial statements. The hierarchy of authoritative accounting guidance is not
expected to change current practice but is expected to facilitate the FASBs plan to designate as authoritative its forthcoming codification of accounting standards. This statement is effective 60 days following the SECs approval of the
PCAOBs related amendments to remove the GAAP hierarchy from its auditing standards.



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Consolidated Results of Operations

Comparison of Quarterly Results of Operations

Percentage comparisons have been omitted within
the following table where they are not considered meaningful. All amounts, except amounts expressed as a percentage, are presented in thousands in the following table.



|                           |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|-------------------------- |  | ------------------------------- | ------- | - | ------ | - | ------- | ------------------------------ |  | - | ------ | - |  | ---- | -- |  | ---- | ------- | - | - | - | ------- | - |  | - | ------- | - |  | --- | --
|                           |  | Three Months EndedSeptember 30, |         |   | Change |   |         | Nine Months EndedSeptember 30, |  |   | Change |  
|                           |  | 2007                            |         |   | 2008   |   |         | $                              |  |   | %      |   |  | 2007 |    |  | 2008 |         |   | $ |   |         | % | 
|Revenue                    |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|License and research fees  |  | $                               | 1,792   |   |        | $ | 100     |                                |  | $ | (1,692 | ) |  | (94  | )% |  | $    | 11,197  |   |   | $ | 1,213   |   |  | $ | (9,984  | ) |  | (89 | )%
|Government grants          |  |                                 | 105     |   |        |   | 62      |                                |  |   | (43    | ) |  | (41  | )% |  |      | 307     |   |   |   | 237     |   |  |   | (70     | ) |  | (23 | )%
|Product revenue            |  |                                 |        |   |        |   | 243     |                                |  |   | 243    |   |  |      |    |  |      | 245     |   |   |   | 972     |   |  |   | 727     |   |  |     |   
|                           |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|Total revenue              |  |                                 | 1,897   |   |        |   | 405     |                                |  |   | (1,492 | ) |  | (79  | )% |  |      | 11,749  |   |   |   | 2,422   |   |  |   | (9,327  | ) |  | (79 | )%
|                           |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|Operating expenses         |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|Cost of product revenue    |  |                                 |        |   |        |   | 77      |                                |  |   | 77     |   |  |      |    |  |      | 68      |   |   |   | 2,906   |   |  |   | 2,838   |   |  |     |   
|Research and development   |  |                                 | 13,774  |   |        |   | 7,603   |                                |  |   | (6,171 | ) |  | (45  | )% |  |      | 39,412  |   |   |   | 27,022  |   |  |   | (12,390 | ) |  | (31 | )%
|Sales and marketing        |  |                                 | 517     |   |        |   | 422     |                                |  |   | (95    | ) |  | (18  | )% |  |      | 1,729   |   |   |   | 1,440   |   |  |   | (289    | ) |  | (17 | )%
|General and administrative |  |                                 | 4,573   |   |        |   | 2,080   |                                |  |   | (2,493 | ) |  | (55  | )% |  |      | 12,761  |   |   |   | 9,689   |   |  |   | (3,072  | ) |  | (24 | )%
|Restructuring              |  |                                 |        |   |        |   | 6,167   |                                |  |   | 6,167  |   |  |      |    |  |      |        |   |   |   | 8,084   |   |  |   | 8,084   |   |  |     |   
|                           |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|Total operating expenses   |  |                                 | 18,864  |   |        |   | 16,349  |                                |  |   | (2,515 | ) |  | (13  | )% |  |      | 53,970  |   |   |   | 49,141  |   |  |   | (4,829  | ) |  | (9  | )%
|Interest income            |  |                                 | 817     |   |        |   | 69      |                                |  |   | (748   | ) |  | (92  | )% |  |      | 2,722   |   |   |   | 497     |   |  |   | (2,225  | ) |  | (82 | )%
|Interest and other expense |  |                                 | (300    | ) |        |   | (195    | )                              |  |   | 105    |   |  | (35  | )% |  |      | (858    | ) |   |   | (697    | ) |  |   | 161     |   |  | (19 | )%
|                           |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   
|Net loss                   |  | $                               | (16,450 | ) |        | $ | (16,070 | )                              |  | $ | (380   | ) |  | (2   | )% |  | $    | (40,357 | ) |   | $ | (46,919 | ) |  | $ | (6,562  | ) |  | 16  | % 
|                           |  |                                 |         |   |        |   |         |                                |  |   |        |   |  |      |    |  |      |         |   |   |   |         |   |  |   |         |   |  |     |   

Comparison of the Three and Nine Months Ended September 30, 2007 to the Three and Nine Months Ended
September 30, 2008

Revenue.We had revenue from certain significant customers, as a percentage of total revenue, as
follows:



|                                            |  |                                  |   |  |                                 |   |  |      |   |  |      |  
|------------------------------------------- |  | -------------------------------- | - |  | ------------------------------- | - |  | ---- | - |  | ---- | -
|                                            |  | Three Months Ended September 30, |   |  | Nine Months Ended September 30, |  
|                                            |  | 2007                             |   |  | 2008                            |   |  | 2007 |   |  | 2008 |  
|P&G                                         |  | 35                               | % |  | 0                               | % |  | 49   | % |  | 0    | %
|QOL                                         |  | 5                                | % |  | 85                              | % |  | 22   | % |  | 55   | %
|Novo Nordisk                                |  | 48                               | % |  | 0                               | % |  | 24   | % |  | 0    | %
|Undisclosed partner  undisclosed compounds |  | 3                                | % |  | 0                               | % |  | 1    | % |  | 23   | %
|Undisclosed partner  Factor IX             |  | 0                                | % |  | 0                               | % |  | 0    | % |  | 11   | %
|                                            |  |                                  |   |  |                                 |   |  |      |   |  |      |  
|Total                                       |  | 91                               | % |  | 85                              | % |  | 96   | % |  | 89   | %
|                                            |  |                                  |   |  |                                 |   |  |      |   |  |      |  

License and research fees revenue.Revenue from license and research fees decreased in the
three and nine months ended September 30, 2008 compared to the three and nine months ended September 30, 2007.

Under our collaborative arrangement with P&G, we received an initial cash payment of $10.0
million in February 2006, which had been recorded as deferred revenue and was being amortized into revenue over the estimated development period. In the three months ended September 30, 2007, license and research fee revenue was primarily
composed of the recognition of current period R&D fees related to our collaboration with P&G, including a portion of the $10.0 million discussed above, as well as recognition of other revenue from other collaboration agreements. We also
received a $2.0 million milestone payment from QOL in connection with the issuance of a U.S. patent for our Nascobal® nasal spray in June 2007. The $2.0 million was recognized in full as
revenue in the second quarter of 2007.

Our agreement with P&G was terminated in November 2007. In addition, in January 2008, Novo
Nordisk terminated their feasibility study agreement with us, and as of the second quarter of 2008, our two feasibility studies with undisclosed partners had been completed. In the three and nine months ended September 30, 2008, license and
research fee revenue was primarily related to recognition of deferred revenue related to the $2.0 million payment received in 2005 from QOL and revenue from other collaboration or feasibility partners.

Government grants revenue.The NIH awarded us a grant in September 2006 for $1.9 million over a five year period to prevent and treat influenza.
Revenue recognized under this grant totaled $0.1 million for both the three month periods ended September 30, 2007 and 2008. Revenue recognized under this grant totaled $0.3 million for the nine month period ended September 30, 2007 and
$0.2 million for the nine month period ended September 30, 2008.



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Product Revenue.During the three and nine
month periods ended September 30, 2007 and 2008, product revenue consisted of sales of our Nascobal® brand products. Product revenue increased to $0.2 million and $0.9 million in the
three and nine months ended September 30, 2008 compared to $0 and $0.2 million in the three and nine months ended September 30, 2007 due to increased product demand. We expect to continue to receive Nascobal® brand product revenue from QOL in the future.

Cost of product revenue.Cost of product revenue consists of raw materials, labor and overhead expenses. At September 30, 2008, the original cost basis of our inventory was approximately $2.7 million, composed of $0.1 million of
Nascobal® API and materials, and $2.6 million of calcitonin-salmon API and materials for our nasal calcitonin-salmon product which is pending FDA approval. Apotex has filed a generic
application for its nasal calcitonin-salmon product with a filing date that has priority over our ANDA for our generic nasal calcitonin-salmon product. In May 2008, the federal district court dismissed the lawsuit between Novartis and Apotex, due to
the parties reaching a settlement in their long-standing litigation. The terms of this settlement were not made public. This created uncertainty over our ability to launch our nasal calcitonin-salmon product and has caused us to reassess the value
of our inventory. In the second quarter of 2008, we recorded a non-cash impairment charge of approximately $2.6 million to cost of goods sold related to the write-down of inventory because we considered the carrying amount of this inventory to
likely not be recoverable. It is possible that we may receive partial or full reimbursement under the terms of our contractual arrangement with Par Pharmaceutical should we not be able to use this material in connection with our manufacturing
arrangement, but the amount and timing of any such reimbursement are not determinable at this time.

We produced two production lots of Nascobal® nasal spray under the supply agreement with QOL in the third quarter of 2008, compared to none in the third
quarter of 2007. We produced eight production lots of Nascobal® nasal spray in the first nine months of 2008 compared with two in the first nine months of 2007. We expect that cost of
product revenue will track consistently to product revenue in the future.

Research and Development.R&D expense consists
primarily of salaries and other personnel-related expenses, costs of clinical trials, consulting and other outside services, laboratory supplies, facilities costs, FDA filing fees, patent filing fees and other costs. We expense all R&D costs as
incurred. R&D expense for the three and nine months ended September 30, 2008 decreased as compared to the 2007 period, due to the following:



| |  |  | Personnel-related expenses decreased by 62% and 49% to $2.0 million and $8.2 million in the three and nine months ended September 30, 2008 compared to $5.2
million and $16.0 million in the three and nine months ended September 30, 2007 due to a decrease in headcount in support of our R&D programs as a result of our restructuring and cost containment efforts.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Facilities and equipment costs decreased by 17% and 10% to $2.0 million and $6.6 million in the three and nine months ended September 30, 2008 compared to $2.4
million and $7.3 million in the three and nine months ended September 30, 2007 due to lower rent and related expenses allocated on a headcount basis. Depreciation expense included in R&D expense in the three and nine month periods ended
September 30, 2008 was $0.7 million and $2.4 million, compared to $0.9 million and $2.4 million in the three and nine month periods ended September 30, 2007.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Non-cash stock-based compensation included in R&D expense was $1.5 million and $3.0 million in the three and nine months ended September 30, 2008 and $0.9
million and $2.2 million in the three and nine months ended September 30, 2007.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | In 2007, we initiated additional Phase 2 clinical trials to evaluate our PYY(3-36) nasal spray in obese patients, PTH(1-34) nasal spray for the treatment of
osteoporosis, our rapid-acting insulin nasal spray in patients with type 2 diabetes and our carbetocin nasal spray for patients with autism spectrum disorders, causing a related increase in 2007 R&D expenses. We discontinued our PTH(1-34)
clinical trial in the first quarter of 2008. Costs of clinical trials, consulting, outside services and laboratory supplies decreased by 63% and 33% to approximately $1.8 million and $8.6 million in the three and nine months ended September 30,
2008 compared to approximately $4.8 million and $12.8 million in the three and nine months ended September 30, 2007. Increased expenses related to RNAi-related research programs and continued spending for the Phase 2 clinical trial for
PYY(3-36) which was completed in July 2008, were offset by decreased spending, as compared to the prior three and nine month periods, on other programs such as carbetocin, insulin and PTH(1-34) which have been placed on hold pending further funding.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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R&D expense by project, as a percentage of total R&D project expense, was as follows:



|                      |  |                                  |   |  |                                 |    |  |      |   |  |      |   
|--------------------- |  | -------------------------------- | - |  | ------------------------------- | -- |  | ---- | - |  | ---- | --
|                      |  | Three Months Ended September 30, |   |  | Nine Months Ended September 30, |   
|                      |  | 2007                             |   |  | 2008                            |    |  | 2007 |   |  | 2008 |   
|Inflammation          |  | 18                               | % |  | 41                              | %  |  | 16   | % |  | 33   | % 
|ApoB and metabolic    |  | 0                                | % |  | 6                               | %  |  | 0    | % |  | 1    | % 
|Oncology              |  | 0                                | % |  | 3                               | %  |  | 0    | % |  | 1    | % 
|Virology/Influenza    |  | 5                                | % |  | 2                               | %  |  | 7    | % |  | 4    | % 
|                      |  |                                  |   |  |                                 |    |  |      |   |  |      |   
|RNAi Subtotal         |  | 23                               | % |  | 52                              | %  |  | 23   | % |  | 39   | % 
|                      |  |                                  |   |  |                                 |    |  |      |   |  |      |   
|PTH(1-34)             |  | 2                                | % |  | 0                               | %  |  | 13   | % |  | 9    | % 
|PYY(3-36)             |  | 29                               | % |  | 52                              | %  |  | 21   | % |  | 34   | % 
|Insulin               |  | 12                               | % |  | 1                               | %  |  | 11   | % |  | 7    | % 
|Carbetocin            |  | 11                               | % |  | (9                              | )% |  | 8    | % |  | (1   | )%
|Calcitonin            |  | 2                                | % |  | 1                               | %  |  | 3    | % |  | 1    | % 
|Other R&D projects(1) |  | 21                               | % |  | 3                               | %  |  | 21   | % |  | 11   | % 
|                      |  |                                  |   |  |                                 |    |  |      |   |  |      |   
|Total                 |  | 100                              | % |  | 100                             | %  |  | 100  | % |  | 100  | % 
|                      |  |                                  |   |  |                                 |    |  |      |   |  |      |   



|(1) | Other R&D projects include our tight junction projects, excipient projects, feasibility projects and other projects.
|--- | --------------------------------------------------------------------------------------------------------------------

We expect our R&D expenses to continue to decrease in the foreseeable future as we implement our restructuring and cost containment efforts. These
expenditures are subject to uncertainties in timing and cost to completion. We test compounds in numerous pre-clinical studies for safety, toxicology and efficacy. We may then conduct early stage clinical trials. If we are not able to engage a
collaboration partner prior to the commencement of later stage clinical trials, or if we decide to pursue a strategy of maintaining commercialization rights to a program, we may fund these trials ourselves. As we obtain results from trials, we may
elect to discontinue or delay clinical trials for certain products in order to focus our resources on more promising products. Completion of clinical trials by us and our collaboration partners may take several years or more, as the length of time
varies substantially according to the type, complexity, novelty and intended use of a drug candidate. The cost of clinical trials may vary significantly over the life of a project as a result of differences arising during clinical development,
including:



| |  |  | the number of sites included in the clinical trials;
| | - |  | ----------------------------------------------------



| |  |  | the length of time required to enroll suitable patient subjects;
| | - |  | ----------------------------------------------------------------



| |  |  | the number of patients that participate in the trials;
| | - |  | ------------------------------------------------------



| |  |  | the duration of patient follow-up that seems appropriate in view of results; and
| | - |  | --------------------------------------------------------------------------------



| |  |  | the number and complexity of safety and efficacy parameters monitored during the study.
| | - |  | ---------------------------------------------------------------------------------------

With the exception of our Nascobal®
spray, none of our current product candidates utilizing our nasal drug delivery technology has received FDA or foreign regulatory marketing approval. In order to achieve marketing approval, the FDA or foreign regulatory agencies must conclude that
our and our collaboration partners clinical data establishes the safety and efficacy of our drug candidates. Furthermore, our strategy includes entering into collaborations with third parties to participate in the development and
commercialization of our products. In the event that the collaboration partner has control over the development process for a product, the estimated completion date would largely be under control of such partner. We cannot forecast with a high
degree of certainty how such collaboration arrangements will affect our development spending or capital requirements.

As a result of the
uncertainties discussed above, we are often unable to determine the duration and completion costs of our R&D projects or when and to what extent we will receive cash inflows from the commercialization and sale of a product.

Sales and marketing.Sales and marketing expense consists primarily of salaries and other personnel-related expenses, consulting, sales materials
and trade shows. The 18% and 17% decrease in sales and marketing expense in the three and nine months ended September 30, 2008 compared to the three and nine months ended September 30, 2007 resulted primarily from decreased staffing as a
result of our restructuring program and cost containment efforts. We expect sales and marketing costs, which include business development staff and activities, to decrease significantly in the next quarter as a result of our most recent reduction in
force and our continued cost containment efforts.



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General and administrative.General and administrative expense consists primarily of salaries and
other personnel-related expenses to support our R&D activities, non-cash stock-based compensation for general and administrative personnel and non-employee members of our board of directors, professional fees, such as accounting and legal,
corporate insurance and facilities costs. The 55% and 24% decrease in general and administrative expenses in the three and nine months ended September 30, 2008 compared to the three and nine months ended September 30, 2007 resulted
primarily from the following:



| |  |  | Personnel-related expenses decreased by 58% and 41% to $0.5 million and $2.2 million in the three and nine months ended September 30, 2008 compared to $1.2
million and $3.7 million in the three and nine months ended September 30, 2007 due primarily to decreased headcount due to our restructuring and cost containment efforts.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Costs of legal and accounting fees, consulting, corporate insurance and other administrative costs decreased 64% and 15% to $0.8 million and $5.1 million in the
three and nine months ended September 30, 2008 compared to $2.2 million and $6.0 million in the three and nine months ended September 30, 2007 due primarily to decreased legal fees in support of our IP patent estate in the third quarter of
2008. These costs decreased by 74% to approximately $0.3 million in the three months ended September 30, 2008 compared to approximately $1.3 million in the three months ended September 30, 2007. Other administrative costs such as office
supplies, printing, conferences and training also decreased due primarily to our cost containment efforts.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Non-cash stock-based compensation included in general and administrative expense decreased from approximately $0.9 million and $2.2 million in the three and nine
months ended September 30, 2007 to $0.4 million and $1.5 million in the three and nine months ended September 30, 2008.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We expect general and administrative expenses to continue to decrease in the foreseeable future.

Restructuring. Commencing
in the fourth quarter of 2007 and continuing in the first nine months of 2008, we implemented plans to restructure operations to concentrate resources on key programs, and we continue to focus on maximizing the performance of our business and
controlling costs to respond to the economic environment. In connection with these operational changes, we suspended further clinical development of our intranasal programs. We have reduced our workforce from approximately 235 employees in late 2007
to approximately 58 full-time employees as of September 30, 2008, including approximately six full-time-equivalents maintaining our manufacturing, quality assurance and quality control operations in support of our current partnerships. We have
recorded restructuring charges related to employee termination costs, our facility consolidation and impairment of assets in accordance with our long-lived assets policy. In addition, we also incurred approximately $0.3 million related to our
decision in the first quarter 2008 to place our Phase 2 PTH(1-34) clinical trial on hold until further funding has been obtained. We continue to work to identify a partner or partners to further develop and commercialize our legacy intranasal
programs through either a sale or licensing transaction; however, there can be no assurance that we will be able to identify suitable partners for our intranasal programs or a sale or licensing transaction on terms acceptable to us or at all.

Our August 2008 workforce reduction included three executives from our intranasal programs. In accordance with the terms of their
employment agreements, the vesting of their outstanding unvested options and restricted stock was accelerated as of September 30, 2008. The related non-cash stock-based compensation expense of approximately $0.9 million was included in
restructuring expense in the three and nine months ended September 30, 2008. We also incurred an additional $1.5 million in employee termination costs in the third quarter of 2008.

During the third quarter of 2008, we closed our facility at 3450 Monte Villa and we began marketing the facility for a sublease tenant. We have recorded
a restructuring liability of approximately $3.1 million, representing remaining lease payments due under the lease and other costs, reduced by sublease rental income that could be reasonably obtained from the property, and discounted using a
credit-adjusted risk-free interest rate. We used a credit-adjusted risk-free interest rate of 15%, and we based our sublease expectations on current rental rates available in the Bothell real estate market, our evaluation of our ability to sublease
our facility in light of tightening credit markets, deteriorating conditions in the Bothell real estate market and increased vacancy rates in the competing downtown real estate markets. The related deferred rent liability of approximately $1.0
million was recorded as a reduction to restructuring expense in the three months ended September 30, 2008. We also incurred approximately $0.1 million in additional costs associated with the September 2008 exit of our 3450 Monte Villa facility.
We expect to incur approximately $1.0 million in accretion expense through the expiration of our 3450 Monte Villa lease in January 2016. As of September 30, 2008, we believe we have completed the employee terminations and facility closures. We
will continue to negotiate an early termination or sublease of the 3450 Monte Villa facility lease to further reduce fixed operating costs.

Given the triggering event as a result of the employee terminations and facility consolidation, we have evaluated our long-lived assets for possible impairment under the guidance in SFAS 144. In the third quarter of 2008, leasehold
improvements having a net book value of approximately $1.5 million were considered impaired by management as they related to our exited facility. A related charge has been included in restructuring expense for the three and nine months ended
September 30, 2008. At the end of the second quarter of 2008, laboratory and manufacturing equipment having a net



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##### Table of Contents

realizable value of approximately $0.4 million, net of estimated costs to sell, was held for sale. We completed the sale of these assets in the third quarter
of 2008. During third quarter of 2008, we had additional property and equipment sales totaling $0.3 million in net book value, and the net loss on sale of approximately $63,000 was included in restructuring expense for the three and nine month
periods ended September 30, 2008. At September 30, 2008, property and equipment having a net realizable value of approximately $1.0 million, net of estimated costs to sell, was held for sale.

Accrued restructuring, and in particular those charges associated with exiting a facility, are subject to managements assumptions and estimates. In
addition to the interest rate used, the assumptions as to estimated sublease rental income, the period of time to execute a sublease and the costs and concessions necessary to enter into a sublease significantly impact the accrual and actual results
may differ from our estimates.

The components of restructuring are summarized as follows (in thousands):



|                                            |  |                                 |   |                                |   |       |  |      |   |  |   |      
|------------------------------------------- |  | ------------------------------- | - | ------------------------------ | - | ----- |  | ---- | - |  | - | -----
|                                            |  | Three Months endedSeptember 30, |   | Nine Months endedSeptember 30,
|                                            |  | 2007                            |   | 2008                           |   | 2007  |  | 2008
|Employee severance and termination benefits |  | $                               |  |                                | $ | 2,363 |  | $    |  |  | $ | 3,986
|Property and equipment impairment           |  |                                 |  |                                |   | 1,592 |  |      |  |  |   | 1,592
|Facility related charges                    |  |                                 |  |                                |   | 2,212 |  |      |  |  |   | 2,212
|Other restructuring charges                 |  |                                 |  |                                |   |      |  |      |  |  |   | 294  
|                                            |  |                                 |   |                                |   |       |  |      |   |  |   |      
|Total restructuring                         |  | $                               |  |                                | $ | 6,167 |  | $    |  |  | $ | 8,084
|                                            |  |                                 |   |                                |   |       |  |      |   |  |   |      

The following table reflects the activity in accrued restructuring for the nine months ended
September 30, 2008 (in thousands):



|                            |  |                                         |        |   |                        |   |       |       |  |   |       |   |  |   |        |  
|--------------------------- |  | --------------------------------------- | ------ | - | ---------------------- | - | ----- | ----- |  | - | ----- | - |  | - | ------ | -
|                            |  | EmployeeSeveranceandTerminationBenefits |        |   | FacilityRelatedCharges |   |       | Other |  |   | Total |  
|Balance, December 31, 2007  |  | $                                       | 151    |   |                        | $ |      |       |  | $ |      |   |  | $ | 151    |  
|Additional accruals         |  |                                         | 3,119  |   |                        |   | 3,180 |       |  |   | 294   |   |  |   | 6,593  |  
|Payments                    |  |                                         | (2,264 | ) |                        |   | (78   | )     |  |   | (294  | ) |  |   | (2,558 | )
|                            |  |                                         |        |   |                        |   |       |       |  |   |       |   |  |   |        |  
|Balance, September 30, 2008 |  | $                                       | 1,006  |   |                        | $ | 3,102 |       |  | $ |      |   |  | $ | 4,186  |  
|                            |  |                                         |        |   |                        |   |       |       |  |   |       |   |  |   |        |  

Interest Income.The 92% and 82% decrease in interest income in the three and nine months
ended September 30, 2008 compared to the three and nine months ended September 30, 2007 was primarily due to lower average balances available for investment in the current year period, as well as lower market interest rates earned on our
invested funds. In January 2007 we raised net proceeds of approximately $40.9 million through issuance of our common stock. In April 2008, we raised net proceeds of approximately $7.3 million through issuance of our common stock and warrants.

Interest and Other Expense.We incurred interest expense on our capital leases. The decrease in interest expense in the three and
nine months ended September 30, 2008 compared to the three and nine months ended September 30, 2007 was due to a decrease in the average borrowings, partially offset by a slightly higher weighted average interest rate.

Contractual Obligations

Our contractual
obligations have changed since December 31, 2007 to September 30, 2008 as follows:



| |  |  | Our purchase obligations decreased by approximately $1.9 million from approximately $2.3 million at December 31, 2007 to approximately $0.4 million at
September 30, 2008 primarily due to the timing of purchase obligations for our clinical trials, which were completed as of September 30, 2008.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our table of contractual obligations at December 31, 2007 and the above disclosure does not include contingent liabilities for which we cannot reasonably predict future amounts and timing, and therefore, excludes
obligations relating to milestone and royalty payments which are contingent upon certain future events as described in Note 8 to our condensed consolidated financial statements. In addition, in October 2008, we announced the termination of
employment of our Chief Scientific Officer, effective November 30, 2008. In connection with the termination, we incurred a severance liability of approximately $1.7 million which will be paid on or before June 30, 2009. The severance
liability is not included in the obligations disclosed above.



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Off-Balance Sheet Arrangements

As of September 30, 2008, we did not have any off-balance sheet arrangements, as defined in Item 303(a)(4)(ii) of SEC Regulation S-K.

ITEM 3  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We are exposed to financial market risk resulting from changes in interest rates. We do not engage in speculative or leveraged transactions, nor do we utilize derivative financial instruments. We invest in interest-bearing instruments that
are classified as cash and cash equivalents, restricted cash and investments. Our investment policy is to manage our total invested funds to preserve principal and liquidity while maximizing the return on the investment portfolio through the full
investment of available funds. We invest in debt instruments of the U.S. Government. Unrealized gains or losses related to fluctuations in interest rates are reflected in other comprehensive income or loss. Based on our cash and cash equivalents and
restricted cash balances at September 30, 2008, a 100 basis point increase or decrease in interest rates would result in an increase or decrease of approximately $0.1 million to interest income on an annual basis.

ITEM 4  CONTROLS AND PROCEDURES

(a) Disclosure Controls and Procedures. As of the end of the period covered by this Quarterly Report on Form 10-Q, we carried out an evaluation, under the supervision and with the participation of our senior
management, including our Chief Executive Officer and Chief Financial Officer, of the effectiveness of the design and operation of our disclosure controls and procedures. Based upon that evaluation, our Chief Executive Officer and Chief Financial
Officer concluded that our disclosure controls and procedures are effective for gathering, analyzing and disclosing the information that we are required to disclose in reports filed under the Securities Exchange Act of 1934, as amended.

(b) Internal Control Over Financial Reporting.There have been no changes in our internal controls over financial reporting or in other factors
during the fiscal quarter ended September 30, 2008, that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting subsequent to the date we carried out our most recent evaluation.

PART II  OTHER INFORMATION

ITEM 1A  RISK FACTORS

In addition to the disclosure in Item 1A  Risk Factors in our annual report on Form
10-K for the year ended December 31, 2007, and the disclosure in Item 1A  Risk Factors in our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2008 and June 30, 2008, you should carefully consider the
additional risk factors set forth below:

If we are unable to comply with the minimum requirements for quotation on the NASDAQ Global Market and are
delisted from the NASDAQ Global Market, the liquidity and market price of our common stock would decline.

On September 19,
2008, we received a letter from the Listing Qualifications Department of the NASDAQ Stock Market notifying us that we were not in compliance with the minimum $1.00 per share minimum bid price requirement for continued inclusion on the NASDAQ Global
Market set forth in NASDAQ Marketplace Rule 4450(a)(5), as a result of the bid price of our common stock having closed below $1.00 for the last 30 consecutive business days prior to the date of the letter. NASDAQs letter advised us that, in
accordance with the NASDAQ Marketplace Rule 4450(e)(2), we will be provided 180 calendar days, or until March 18, 2009, to regain compliance. The letter further advises that such compliance can be achieved if, at any time before March 18,
2009, the bid price of our common stock closes at $1.00 or more per share for a minimum of 10 consecutive business days. On October 16, 2008, NASDAQ suspended enforcement of the minimum bid price requirement through January 16, 2009, and
accordingly, our date to regain compliance with the continued listing requirement of NASDAQ Marketplace Rule 4450(a)(5) has been extended to June 22, 2009. There can be no assurance that we will be able to regain compliance with the continued
listing requirement of NASDAQ Marketplace Rule 4450(a)(5).

If we do not regain compliance by June 22, 2009, NASDAQ will provide us
with written notification that our common stock may be delisted. At that time, we may appeal NASDAQs decision to a Listing Qualifications Panel pursuant to the Marketplace Rule 4800 series. Alternatively, we may apply to transfer the listing
of our common stock to the NASDAQ Capital Market if we satisfy the requirements for initial inclusion set forth in Marketplace Rule 4310(c) (other than the minimum bid price requirement of Rule 4310(c)(4)). If our application is approved, we will be
afforded the remainder of the second 180 calendar day compliance period in order to regain compliance with the minimum bid price requirement while our common stock trades on the NASDAQ Capital Market.



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If we were to be delisted from the NASDAQ Global Market, or are unable to transfer the listing of our
common stock to the NASDAQ Capital Market, trading, if any, in our shares may continue to be conducted on the Over the Counter Bulletin Board or in a non-NASDAQ over-the-counter market, such as the pink-sheets. Delisting of our shares
would result in limited release of the market price of those shares and limited analyst coverage and could restrict investors interest in our securities. Also, a delisting could have a material adverse effect on the trading market and prices
for our shares and our ability to issue additional securities or to secure additional financing. In addition, if our shares were not listed and the trading price of our shares was less than $5.00 per share, our shares could be subject to Rule 15g-9
under the Securities Exchange Act of 1934, as amended, which, among other things, requires that broker/dealers satisfy special sales practice requirements, including making individualized written suitability determinations and receiving a
purchasers written consent prior to any transaction. In such case, our securities could also be deemed to be a penny stock under the Securities Enforcement and Penny Stock Reform Act of 1990, which would require additional
disclosure in connection with trades, including the delivery of a disclosure schedule explaining the nature and risks of the penny stock market. Such requirements could severely limit the liquidity of our securities and our ability to raise
additional capital.

ITEM 6  EXHIBITS

The exhibits required by this item are set forth in the Exhibit Index attached hereto.



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the
undersigned, duly authorized, in Bothell, State of Washington, on November 13, 2008.



MDRNA, INC.By:

/s/ J. Michael FrenchJ. Michael French Chief Executive
OfficerBy:

/s/ Bruce R. YorkBruce R. York Chief Financial
Officer




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##### Table of Contents

EXHIBIT INDEX



|            |  |                                                                                                                                                                                                                                                                                                                           
|----------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                                                                                                                                                                                               
|            | 
|2.1         |  | Agreement and Plan of Reorganization, dated August 8, 2000, among the Registrant, Atossa Acquisition Corporation, a Delaware corporation and our wholly-owned subsidiary, and Atossa
HealthCare, Inc. (filed as Exhibit 2.1 to our Current Report on Form 8-K dated August 8, 2000, and incorporated herein by reference).
|            | 
|2.2         |  | Asset Purchase Agreement, dated September 30, 2002, between the Registrant and Schwarz Pharma, Inc. (filed as Exhibit 2.1 to our Current Report on Form 8-K dated September 30, 2002,
and incorporated herein by reference).                                                                                              
|            | 
|3.1         |  | Restated Certificate of Incorporation of the Registrant dated July 20, 2005 (filed as Exhibit 3.1 to our Current Report on Form 8-K dated July 20, 2005, and incorporated herein by
reference).                                                                                                                           
|            | 
|3.2         |  | Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant, dated June 10, 2008 (filed as Exhibit 3.1 to our Current Report on Form 8-K dated
June 10, 2008, and incorporated herein by reference).                                                                              
|            | 
|3.3         |  | Amended and Restated Bylaws of the Registrant dated September 19, 2007 (filed as Exhibit 3.1 to our Current Report on Form 8-K dated September 19, 2007, and incorporated herein by
reference).                                                                                                                           
|            | 
|3.4         |  | Certificate of Designation, Rights and Preferences of Series A Junior Participating Preferred Stock dated January 17, 2007 (filed as Exhibit 3.1 to our Current Report on Form 8-K dated
January 19, 2007, and incorporated herein by reference).                                                                         
|            | 
|3.5         |  | Amended Designation, Rights, and Preferences of Series A Junior Participating Preferred Stock, dated June 10, 2008 (filed as Exhibit 3.2 to our Current Report on Form 8-K dated
June 10, 2008, and incorporated herein by reference).                                                                                    
|            | 
|4.1         |  | Rights Agreement, dated February 22, 2000, between the Registrant and American Stock Transfer & Trust Company as Rights Agent (filed as Exhibit 1 to our Current Report on Form 8-K dated
February 22, 2000, and incorporated herein by reference).                                                                       
|            | 
|4.2         |  | Amendment No. 1 to Rights Agreement dated as of January 17, 2007 by and between the Registrant and American Stock Transfer and Trust Company (filed as Exhibit 4.1 to our Current Report on
Form 8-K dated January 19, 2007, and incorporated herein by reference).                                                       
|            | 
|4.3         |  | Securities Purchase Agreement dated as of June 25, 2004 (filed as Exhibit 99.2 to our Current Report on Form 8-K dated June 25, 2004, and incorporated herein by
reference).                                                                                                                                              
|            | 
|10.1        |  | Lease Agreement for facilities at 45 Davids Drive, Hauppauge, NY, effective as of July 1, 2005 (filed as Exhibit 10.30 to our Quarterly Report on Form 10-Q for the quarter ended
March 31, 2005, and incorporated herein by reference).                                                                                  
|            | 
|10.2        |  | Lease Agreement, dated April 23, 2002, with Phase 3 Science Center LLC, Ahwatukee Hills Investors LLC and J. Alexanders LLC (filed as Exhibit 10.26 to our Quarterly Report on Form
10-Q for the quarter ended March 31, 2002, and incorporated herein by reference).                                                    
|            | 
|10.3        |  | First Amendment dated June 17, 2003, to Lease Agreement dated April 23, 2002, with Phase 3 Science Center LLC, Ahwatukee Hills Investors LLC and J. Alexanders LLC (filed as
Exhibit 10.2 to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2003, and incorporated herein by reference).               
|            | 
|10.4        |  | Second Amendment, dated February 4, 2004, to Lease Agreement dated April 23, 2002, with Phase 3 Science Center LLC, Ahwatukee Hills Investors LLC and J. Alexanders LLC (filed as
Exhibit 10.24 to our Annual Report on Form 10-K for the year ended December 31, 2003, and incorporated herein by reference).           
|            | 
|10.5        |  | Lease Agreement for facilities at 80 Davids Drive, Hauppauge, NY, effective as of July 1, 2005 (filed as Exhibit 10.5 to our Quarterly Report on Form 10-Q for the quarter ended
June 30, 2005, and incorporated herein by reference).                                                                                    
|            | 
|10.6        |  | Lease Agreement with Ditty Properties Limited Partnership for facilities at 3830 Monte Villa Parkway, Bothell, WA, effective as of March 1, 2006 (filed as Exhibit 10.1 to Amendment No. 1 to
our Current Report on Form 8-K/A dated March 1, 2006 and filed on July 26, 2006, and incorporated herein by reference).(1)  



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|            |  |                                                                                                                                                                                                                                                                                                            
|----------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                                                                                                                                                                                
|            | 
|10.7        |  | First Amendment to Lease Agreement with Ditty Properties Limited Partnership for facilities at 3830 Monte Villa Parkway, Bothell, WA, effective as of July 17, 2006 (filed as Exhibit 10.7 to
our Quarterly Report on Form 10-Q for the quarter ended June 30, 2006, and incorporated herein by reference).
|            | 
|10.8        |  | Amended and Restated Employment Agreement dated December 16, 2005 by and between the Registrant and Steven C. Quay, M.D., Ph.D. (filed as Exhibit 10.1 to our Current Report on Form 8-K
dated December 16, 2005, and incorporated herein by reference).                                                   
|            | 
|10.9        |  | Amended and Restated Employment Agreement dated June 10, 2008 by and between the Registrant and Steven C. Quay, M.D., Ph.D. (filed as Exhibit 10.1 to our Current Report on Form 8-K dated
June 10, 2008, and incorporated herein by reference).                                                           
|            | 
|10.10       |  | Employment Agreement effective as of August 17, 2006 by and between the Registrant and Dr. Gordon C. Brandt (filed as Exhibit 10.1 to our Current Report on Form 8-K dated August 17,
2006, and incorporated herein by reference).                                                                         
|            | 
|10.11       |  | Employment Agreement dated December 19, 2007 between the Registrant and Dr. Gordon C. Brandt (filed as Exhibit 10.1 to our Current Report on Form 8-K dated December 19, 2007, and
incorporated herein by reference).                                                                                      
|            | 
|10.12       |  | Employment Agreement effective as of September 15, 2006 by and between the Registrant and Timothy M. Duffy (filed as Exhibit 10.1 to our Current Report on Form 8-K dated September 15,
2006, and incorporated herein by reference).                                                                       
|            | 
|10.13       |  | Employment Agreement effective as of March 7, 2008 by and between the Registrant and Bruce R. York (filed as Exhibit 10.1 to our Current Report on Form 8-K dated March 10, 2008, and
incorporated herein by reference).                                                                                   
|            | 
|10.14       |  | Employment Agreement effective as of June 23, 2008 by and between the Registrant and J. Michael French (filed as Exhibit 10.2 to our Current Report on Form 8-K dated June 10, 2008, and
incorporated herein by reference).                                                                                
|            | 
|10.15       |  | Employment Agreement effective as of January 2, 2009 by and between the Registrant and Barry Polisky (filed as Exhibit 10.1 to our Current Report on Form 8-K dated October 27, 2008 and
incorporated herein by reference).                                                                                
|            | 
|10.16       |  | The Registrants 1990 Stock Option Plan (filed as Exhibit 4.2 to our Registration Statement on Form S-8, File No. 333-28785, and incorporated herein by reference).                                                                                                                                        
|            | 
|10.17       |  | The Registrants Amended and Restated 2000 Nonqualified Stock Option Plan (filed as Exhibit 4.4 to our Registration Statement on Form S-8, File No. 333-49514, and incorporated herein by
reference).                                                                                                      
|            | 
|10.18       |  | Amendment No. 1 to the Registrants Amended and Restated 2000 Nonqualified Stock Option Plan (filed as Exhibit 10.18 to our Annual Report on Form 10-K for the year ended December 31,
2005, and incorporated herein by reference).                                                                        
|            | 
|10.19       |  | Amendment No. 2 to the Registrants Amended and Restated 2000 Nonqualified Stock Option Plan (filed as Exhibit 10.19 to our Quarterly Report on Form 10-Q for the quarter ended
September 30, 2006, and incorporated herein by reference).                                                                 
|            | 
|10.20       |  | The Registrants 2002 Stock Option Plan (filed as Exhibit 10.28 to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2002, and incorporated herein by
reference).                                                                                                                           
|            | 
|10.21       |  | Amendment No. 1 to the Registrants 2002 Stock Option Plan (filed as Exhibit 10.20 to our Annual Report on Form 10-K for the year ended December 31, 2005, and incorporated herein by
reference).                                                                                                          
|            | 
|10.22       |  | The Registrants 2004 Stock Incentive Plan (filed as Exhibit 99 to our Registration Statement on Form S-8, File No. 333-118206, and incorporated herein by reference).                                                                                                                                     
|            | 
|10.23       |  | Amendment No. 1 to the Registrants 2004 Stock Incentive Plan (filed as Exhibit 10.4 to our Current Report on Form 8-K dated July 20, 2005, and incorporated herein by
reference).                                                                                                                         
|            | 
|10.24       |  | Amendment No. 2 to the Registrants 2004 Stock Incentive Plan (filed as Exhibit 10.18 to our Quarterly Report on Form 10-Q for the quarter ended September 30, 2005, and incorporated
herein by reference).                                                                                                



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##### Table of Contents

|            |  |                                                                                                                                                                                                                                                                    
|----------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                                                                                                                                        
|            | 
|10.25       |  | Amendment No. 3 to the Registrants 2004 Stock Incentive Plan (filed as Exhibit 10.24 to our Annual Report on Form 10-K for the year ended December 31, 2005, and incorporated herein by
reference).                                                               
|            | 
|10.26       |  | Amendment No. 4 to the Registrants 2004 Stock Incentive Plan (filed as Exhibit 10.5 to our Registration Statement on Form S-8, File No 333-135724, and incorporated herein by reference).                                                                         
|            | 
|10.27       |  | Amendment No. 5 to the Registrants 2004 Stock Incentive Plan (filed as Exhibit 10.27 to our Quarterly Report on Form 10-K for the quarter ended September 30, 2006, and incorporated
herein by reference).                                                        
|            | 
|10.28       |  | The Registrants 2008 Stock Incentive Plan (filed as Appendix A to our Definitive Proxy Statement on Schedule 14A filed on April 29, 2008, and incorporated herein by
reference).                                                                                  
|            | 
|10.29       |  | Asset Purchase Agreement dated June 16, 2003, by and between the Registrant and Questcor Pharmaceuticals, Inc. (filed as Exhibit 2.1 to our Current Report on Form 8-K dated June 17,
2003, and incorporated herein by reference).                                 
|            | 
|10.30       |  | Form of Purchase Agreement (filed as Exhibit 99.2 to our Current Report on Form 8-K dated September 4, 2003, and incorporated herein by reference).                                                                                                                
|            | 
|10.31       |  | Form of Warrant (filed as Exhibit 99.3 to our Current Report on Form 8-K dated September 4, 2003, and incorporated herein by reference).                                                                                                                           
|            | 
|10.32       |  | License and Supply Agreement by and between Par Pharmaceutical Companies, Inc. and the Registrant effective as of October 22, 2004 (filed as Exhibit 10.1 to our Current Report on Form 8-K
dated October 22, 2004, and incorporated herein by reference).(1)      
|            | 
|10.33       |  | Agreement dated as of September 23, 2005 by and between the Registrant and QOL Medical, LLC (filed as Exhibit 10.1 to our Current Report on Form 8-K/A dated October 17, 2005 and filed
on July 26, 2006, and incorporated herein by reference).(1)                
|            | 
|10.34       |  | Development and License Agreement by and between the Registrant and Amylin Pharmaceuticals, Inc. dated June 23, 2006 (filed as Exhibit 10.66 to our Quarterly Report on Form 10-Q for the
quarter ended June 30, 2006, and incorporated herein by reference).(1)   
|            | 
|10.35       |  | Form of Restricted Stock Grant Agreement (filed as Exhibit 10.1 to our Current Report on Form 8-K dated February 6, 2007, and incorporated herein by reference).                                                                                                   
|            | 
|10.36       |  | Form of Stock Option Agreement (filed as Exhibit 10.2 to our Current Report on Form 8-K dated February 6, 2007, and incorporated herein by reference).                                                                                                             
|            | 
|10.37       |  | Form of Omnibus Amendment to Certain Grant Agreements, dated May 4, 2007 (filed as Exhibit 10.42 to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2007, and
incorporated herein by reference.                                                  
|            | 
|10.38       |  | The Registrants 2007 Employee Stock Purchase Plan (filed as Exhibit 10.1 to our Registration Statement on Form S-8, File No. 333-146183, and incorporated herein by
reference).                                                                                   
|            | 
|10.39       |  | Placement Agency Agreement, dated March 7, 2008, between the Registrant and Maxim Group LLC (filed as Exhibit 10.1 to our Current Report on Form 8-K dated April 25, 2008, and
incorporated herein by reference).                                                  
|            | 
|10.40       |  | Securities Purchase Agreement, dated as of April 25, 2008, between the Registrant and the purchasers identified on the signature page thereto (filed as Exhibit 10.2 to our Current Report on
Form 8-K dated April 25, 2008, and incorporated herein by reference).
|            | 
|10.41       |  | Form of Warrant (filed as Exhibit 10.3 to our Current Report on Form 8-K dated April 25, 2008, and incorporated herein by reference).                                                                                                                              
|            | 
|10.42       |  | Escrow Agreement, dated as of April 25, 2008, between the Registrant, Maxim Group LLC and American Stock Transfer & Trust Company (filed as Exhibit 10.4 to our Current Report on Form
8-K dated April 25, 2008, and incorporated herein by reference).            



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##### Table of Contents

|            |  |                                                                                                                                                          
|----------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                              
|            | 
|31.1        |  | Certification of our Chief Executive Officer pursuant to Rules 13a-14 and 15d-14 under the Securities Exchange Act of 1934, as amended.(2)               
|            | 
|31.2        |  | Certification of our Chief Financial Officer pursuant to Rules 13a-14 and 15d-14 under the Securities Exchange Act of 1934, as amended.(2)               
|            | 
|32.1        |  | Certification of our Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.(2)
|            | 
|32.2        |  | Certification of our Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.(2)



|(1) | Portions of this exhibit have been omitted pursuant to a request for confidential treatment under Rule 24b-2 of the Securities and Exchange Act of 1934, amended, and the omitted
material has been separately filed with the Securities and Exchange Commission.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | Filed Herewith.
|--- | ---------------



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