Nicosulfuron 

PC Code 129008 

Dietary Exposure and Risk Assessment DP# 417840 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

DATE: 03/17/2014 

SUBJECT: Nicosulfuron: Chronic Aggregate Dietary (Food plus Drinking Water) 

Exposure and Risk Assessments in Support of a Section 3 Registration on 

Acetolactase Synthase (ALS) Tolerant Grain Sorghum. 

PC Code: 129008 DP Barcode: D417840 

Decision Number: 473409 

Petition Number: 2F8132 

Risk Assessment Type: NA 

TXR Number: NA 

Registration Numbers: 352-560, 352-816 

Regulatory Action: Section 3 Registration 

Case Number: NA 

CAS Number: 111991-09-4 

MRID Numbers: NA 40CFR: § 180.454 

FROM: C f-/-/ e ·· / ,Jc_9L#< ·~ Meheret N egussie, hemist 1 r <A1 'f'C.T U 

Risk Assessment Branch III (RAB3) 

Health Effects Division (HED; 7509P) 

, 

THROUGH: . Thurston Morton, Senior Chemist _ 1 _ __ c . L~ (;)_, "'". / 

Mohsen Sahafeyan, Chemist ~ ~0-rv.w- OOJ' ~ ~­

Dietary Exposure Science Advisory Council (DESA 

Health Effects Division (HED; 7509P) 

Christine 

and 

Olinger, Branch Chief ~ 

/Jf

r 

/ /-/~ ' 

RAB3/HED (7509P) 

TO: Kristin Rury, Biologist/Risk Assessor 

RAB3/HED (7509P) 

and 

Mindy Ondish and Kable Davis, RM# 25 

Herbicide Branch 

Registration Division (7505P) 

Page 1 of 10 
Nicosulfuron Dietary Exposure and Risk Assessment DP# 417840 

PC Code 129008 

Executive Summary 

Chronic aggregate dietary (food and drinking water) exposure and risk assessment was 

conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 

food consumption data from the U.S. Department of Agriculture's (USDA's) National 

Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). The analyses were conducted in support of a human health risk 

assessment for the proposed Section 3 requests on acetolactase synthase (ALS) tolerant 

grain sorghum. This memorandum was reviewed by two peer reviewers of the DESAC, 

per DESAC SOP 2012.1. 

Acute and Cancer Dietary Exposure 

No acute dietary toxicity endpoint could be identified based on the toxicology data 

currently available for nicosulfuron; therefore, an acute assessment was not performed. 

The Cancer Assessment Review Committee (CARC) classified nicosulfuron as "not 

likely to be carcinogenic to humans;" therefore, a cancer assessment was not performed. 

Chronic Dietary Exposure Results and Characterization 

Chronic (food and drinking water) dietary assessment was conducted assuming tolerance 

level residues for all crops, 100% crops are treated (CT), and DEEM version 7.81 default 

processing factors. The estimated drinking water concentration (EDWC) (19.2 ppb) was 

incorporated directly into the dietary assessment. 

The results of the chronic dietary (food and drinking water) analysis indicate that 

exposure and risk does not exceed RED's level of concern (LOC) for the U.S. population 

and all population subgroups. The dietary exposure for food and water is estimated at 

<1% of the chronic Population Adjusted Dose ( cP AD) for the general U.S. population 

and all population subgroups. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: "Available 

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Nicosulfuron Dietary Exposure and Risk Assessment DP# 41 7840 

PC Code 129008 

Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EP A-PEST/2000/July/Day-12/606l.pdf ~ or see 

SOP 99.6 (20-AUG-1999). 

The most recent dietary risk assessment for nicosulfuron was conducted by M. Doherty 

(DP# 369744, 10/ 15/2009). 

II. Residue Information 

For plants and livestock, the residue of concern (ROC) for tolerance enforcement and risk 

assessment is the parent compound, nicosulfuron. The residues of concern for drinking 

water include parent nicosulfuron and all major degradates which maintain the 

sulfonylurea bridge which include degradates identified as IN-HYY21 and IN-37740 

(DP# D416835, K. Rury, 12/18/2012). Therefore, the total residue method was used to 

estimate exposure in drinking water sources. 

Existing and recommended tolerance-level residues (40 CFR §180.454] have been used 

for all food commodities in this assessment. The existing tolerances are 0.1 ppm for all 

com commodities. The recommended tolerances for livestock commodities (of cattle, 

horses, and sheep only) are 0.01 ppm for meat and fat, 0.05 ppm for meat byproducts, 

and 0.01 ppm for milk. DEEM default processing factor was used where available. In 

addition, it was assumed that 100% of foods in the assessment had residues of 

nicosulfuron (i.e .• 100% crop treated). The inputs used in the assessment are provided in 

Attachment 1. 

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 

2008, 2009, and 2010. In general, pesticide residues would not be expected to be found 

in fish unless the pesticide bioaccumulates or has an aquatic use. To determine whether 

or not residues are present in fish, HED now routinely checks PDP monitoring data 

regardless of the pesticide's uses and physicochemical properties. However, PDP did not 

analyze catfish samples for nicosulfuron. As a result, residues in fish were not included 

in the assessment. 

For the proposed new use on sorghum, tolerance level (0.8 ppm) is recommended (DP# 

D417854, M. Negussie, 03/17/2014). 

III. Percent Crop Treated Information 

100% CT was assumed for all crops. 

IV. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) (DP# 414505, G. Rothman, 

03/13/2014) and incorporated directly into this dietary assessment. Water residues were 

incorporated in DEEM-FCID into the food categories "water, direct, all sources" and 

"water, indirect, all sources." 

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Nicosulfuron Dietary Exposure and Risk Assessment DP# 417840 

PC Code 129008 

Estimated drinking water concentrations (EDWCs) in surface waters are estimated using 

the Tier 2 model PRZM/EXAMS (Pesticide Root Zone Model)/(Exposure Analysis 

Modeling System). Based on PRZM/EXAMS, the concentrations of nicosulfuron, INHYY21, and IN-37740 in surface drinking water sources are not likely to exceed 9.67 

jlg/L (9.67 ppb) for the acute peak concentration, 2.80 jlg/L (2.80 ppb) for the chronic 

concentration, and 2.15 jlg/L (2.15 ppb) for the cancer concentration. 

Ground water estimates of concentrations are estimated using the PRZM-GW (Ground 

Water). PRZM-GW model estimates upper-bound concentrations ofnicosulfuron, INHYY21 , and IN-37740 in ground drinking water sources are not likely to exceed 26.3 

jlg/L (26.3 ppb) for acute exposure and 19.2jlg/L (19.2 ppb) for chronic and cancer 

exposure. The PRZM -G W estimate was higher compared to surface water estimated 

concentrations. Therefore, the chronic ground water estimate (19.2 ppb) was used in the 

assessment. Estimates were derived based on the use on sorghum and are considered 

worst-case. The model and its description are available at the EPA internet site: 

http://www .epa. gov I oppefed 1/models/water/ 

I 

Table 1. Comparison ofPRZM-GW, SCI-GROW, and PRZMIEXAMS estimated upper bound 

concentrations for nicosulfuron and degradates of concern including IN-HYY21 and IN-37740. 

PRZM-GW SCI-GROW 

Exposure Duration (ppb) (ppb)l PRZMIEXAMS 

Highest Daily Cone. 26.3 9.67 (Acute) 

Post-Breakthrough 

Average Cone. 1.42 2.80 

(Chronic and Cancer) 19.22 

30-year Mean 

2.15 (Cancer) 

SCI-GROW modeling conservatively assumes that ground water concentratiOns are umform over time and 

therefore, acute, chronic, and cancer concentration are the same. 

2 The highest estimated concentration is bolded. 

V. DEEM-FCIDTM Program and Consumption Information 

Nicosulfuron chronic dietary exposure assessment was conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods "as consumed" (e.g., 

apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruitcooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups. However, for acute exposure assessment, consumption 

data are retained as individual consumption events. Based on analysis of the 2003-2008 

WWEIA consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

Page 4 of 10 
Nicosulfuron Dietary Exposure and Risk Assessment DP# 417840 

PC Code 129008 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mglkg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup. 

VI. Toxicological Information 

No acute hazard, attributable to a single dose, was identified; therefore, an acute dietary 

endpoint was not selected for quantitative risk assessment. 

The toxicity endpoints pertinent for human health dietary risk assessment are summarized 

in Table 2. 

Table 2. Summary of Toxicological Doses and Endpoints for Nicosulfuron for Use in Dietary 

Human Health Risk Assessments 

Exposure/ Point of Uncertainty RfD&PAD, Study and Toxicological Effects 

and FQPA for Risk Scenario Departure Safety Factors Assessment 

Acute Dietary An endpoint of concern attributable to a single dose was not identified. (All 

populations) 

Oral toxicity - dog 

NOAEL = 125 mglkg/day based 

upon decreased body weight gain 

Chronic RID in males and the statistically 

Chronic Dietary UFA= lOx = significant increase in the relative 

(All NOAEL= 12 UFH= lOx cPAD = liver and kidney weights of males 

Populations) 5 mglkg/day FQPA SF= lx 1.25mglkg/da at the LOAEL of 500 mglkg/day. 

y Supported by the NOAEL of 1 00 

mglkglday/LOAEL 500 mglkglday 

in the rabbit developmental toxicity 

study. 

Cancer (oral, Classification: "Not likely to be Carcinogenic to Humans" based on lack of 

dermal, tumorigenic effects in rodent (rats and mice) bioassays at the limit doses and lack of 

inhalation) mutagenic effects in the in vitro and in vivogenotoxicity assays. 

Point of Departure (POD) = A data pomt or an est•mated pomt that IS denved from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c =chronic). 

RID = reference dose. 

VII. Results/Discussion 

Page 5 of 10 
Nicosulfuron Dietary Exposure and Risk Assessment DP# 4 17840 

PC Code I29008 

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 3 are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-

12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis 

The results of the chronic dietary (food and drinking water) analysis indicate that 

exposure and risk does not exceed HED's LOC for the U.S. population and all population 

subgroups. The dietary exposure for food and water is estimated at <1% of the cPAD for 

the general U.S. population and all population subgroups. The results of the chronic 

dietary analyses (food plus drinking water) are reported in Table 3 below. 

Table 3. Result of Chronic Dietary Exposure and Risk Estimates for Nicosulfuron. 

Population Subgroup cPAD, Chronic Estimates (Food and Drinking Water) 

mg/kg/day Exposure, mg/kg/day Risk,% cPAD 

U.S. Population 1.25 0.000678 <I 

All infants 0.001548 <1 

Children l-2 yrs 0.001462 <I 

Children 3-5 yrs 0.001208 <l 

Children 6-12 yrs 0.000846 <1 

Youth 13-19 yrs 0.000603 <1 

Adults 20-49 yrs 0.000623 <1 

Adults 50-99 yrs 0.000541 <I 

Females 13-49 yrs 0.000612 <I 

The populatiOn subgroup with the highest estimated exposure/nsk 1s bolded. 

VIII. Characterization of Inputs/Outputs 

The dietary exposure and risk estimates are unrefined since they assume tolerance level 

residues, 100 %CT, and include default processing factors. Additional refinements may 

be implemented such as the use of anticipated residues, incorporation of %CT data, and 

inclusion of empirical processing factors. HED concludes that the chronic dietary 

exposure and risk estimates are not underestimated. 

IX. Conclusions 

An unrefined dietary (food and drinking water) exposure and risk assessment was 

performed for nicosulfuron. The inputs and assumptions used in this assessment are 

highly conservative with respect to dietary exposure and the exposure estimates presented 

in Table 3 are likely to overestimate any actual dietary exposures to nicosulfuron. 

The chronic dietary (food and drinking water) exposure estimates are below HED's LOC 

(<100% cPAD) for the general U.S. population and all population subgroups. 

Nicosulfuron dietary (food and drinking water) risk is <1% of the cP AD for the U.S. 

population and all population subgroups. 

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Nicosulfuron Dietary Exposure and Risk Assessment DP# 417840 

PC Code 129008 

X. List of Attachments 

1. Attachment 1. Chronic Food Plus Water Residue Input file 

2. Attachment 2. Chronic Results files: Food Plus Water 

3. Attachment 3. Chronic Results files: Food Alone 

Page 7 of 10 
Nicosulfuron Dietary Exposure and Risk Assessment DP# 417840 

PC Code 129008 

Attachment 1. Chronic Food Plus Water Residue Input file 

U.S . EPA Ver . 3 . 16, 03 - 08-d 

DEEM-FCI D Chronic analysis for NI COSULFURON 

Residue fil e : C:\Documents and Settings\MNEGUSSI \My Documents\DEEM Version 

3.16\Nicosulfuron\Chronic_Nicosulfuron2014 . R08 

Adjust . #2 NOT used 

Anal ysis Date 02 - 18- 2014 Residue file dated: 02-18-2014/14:40 : 39 

Reference dose (RfDl = 1.25 mg/kg bw/day 

Comment:Sorghum use 

Food Crop 

EPA Code Grp Food Name 

3100044000 31 

3100044001 31 

3100045000 31 

310004 6000 31 

3100046001 31 

310004 7000 31 

3100047001 31 

3100048000 31 

3100049000 31 

3100049001 3 1 

1500120000 15 

1500120001 1 5 

1500121000 15 

1500121001 15 

1500122000 15 

1500123000 15 

1500123001 15 

1 500124000 15 

1500124001 15 

1500125000 15 

1500125001 15 

1 500126000 15 

1500127000 15 

1500127001 15 

3200169000 32 

3200170000 32 

3200171000 32 

3200172000 32 

3200173000 32 

3300189000 33 

3800221000 38 

3600222000 36 

3600222001 36 

3600223000 36 

3600223001 36 

3600224000 36 

3600224001 36 

3600225001 36 

3500339000 35 

3500339001 35 

3500340000 35 

3500341000 35 

3500341001 35 

3500342000 35 

3500343000 35 

1500344000 1 5 

1500345000 15 

8601000000 86A 

8602000000 86B 

Beef, meat 

Beef, meat- babyfood 

Beef, meat, dried 

Bee f, meat byproducts 

Beef, meat byproducts- babyfood 

Beef, fat 

Beef, fat- babyfood 

Beef, kidney 

Bee f , l iver 

Beef , l iver-babyfood 

Corn, field, flour 

Corn, field , flour-babyfood 

Corn, field, meal 

Corn, field, meal-babyfood 

Corn, field, bran 

Corn, field, starch 

Corn, field, starch-babyfood 

Corn, field, syrup 

Corn, field, syrup-babyf ood 

Corn, fiel d, oil 

Corn, fiel d, oil -babyfood 

Corn, pop 

Corn, sweet 

Corn, sweet-babyfood 

Goat, meat 

Goat, meat byproducts 

Goat, fat 

Goat, kidney 

Goat, l iver 

Horse, meat 

Meat, game 

Milk, fat 

Milk, fat-baby food/ infant formu 

Milk, nonfat solids 

Milk, nonfat solids-baby food/ i n 

Milk, water 

Milk, water-babyfood/infant form 

Milk, sugar (lactose) - baby food/ 

Sheep, meat 

Sheep, meat-babyf ood 

Sheep, meat byproducts 

Sheep, f a t 

Sheep, fat-babyfood 

Sheep, kidney 

Sheep, l iver 

Sorghum, grai n 

Sorghum, syrup 

Water, direct, all sources 

Water, indirect, all sources 

Page 8 of 10 

Residue 

(ppm) 

0.010000 

0.010000 

0 . 010000 

0 . 050000 

0 . 050000 

0.010000 

0 . 010000 

0 . 050000 

0 . 050000 

0.050000 

0 . 100000 

0 . 100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0 . 100000 

0 . 100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.010000 

0 . 050000 

0 . 010000 

0 . 050000 

0 . 050000 

0.010000 

0.010000 

0.010000 

0 .010000 

0 . 010000 

0.010000 

0.010000 

0.010000 

0 . 010000 

0.010000 

0.010000 

0 . 050000 

0 . 010000 

0 . 010000 

0.050000 

0.050000 

0.800000 

0.800000 

0 . 019200 

0.019200 

Adj.Factors 

#1 #2 

1. 000 

1. 000 

1 . 920 

1. 000 

1. 000 

1. 000 

1. 000 

1 .000 

1 . 000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 .000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1.000 

1 . 000 

1 . 000 

1. 000 

1.000 

1. 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1. 000 

1 .000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1 . 000 

1 . 000 

1 .000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 .000 

1.000 

1.000 

1 .000 

1.000 

1 .000 

1.000 

1 .000 

1.000 

1.000 

1 . 000 

1 . 000 

1 .000 

1 . 000 

1 .000 

1 .000 

1 . 000 

1.000 

1.000 

1. 000 

1. 000 

1 .000 
Nicosulfuron Dietary Exposure and Risk Assessment DP# 417840 

PC Code 129008 

Attachment 2. Chronic Results files: Food Plus Water 

U. S. EPA Ver. 3 .16, 03-08 -d 

DEEM- FCID Chronic analysis for NICOSOLFORON NHANES 2003-2008 2-day 

Residue fil e name: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 

3.16\Nicosulfuron\Chronic_Ni cosulfuron2014 .R08 

Adjustmen t factor #2 NOT used. 

Anal ysis Date 02-18-2014/14:42:05 Residue file dated: 02 -18-2014/14:40:39 

Reference dose (RfD, Chronic) = 1.25 mg/kg bw/day 

COMMENT 1: Sorghum use 

=============================================================================== 

Population 

Subgroup 

Total US Populati on 

Hispanic 

Non-Hisp-Whi te 

Non-Hisp-Black 

Non- Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Femal e 13+ PREG 

Children 1-6 

Children 7 -12 

Male 13 -19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20 - 49 

Adults 50-99 

Female 13-49 

Total exposure by population subgroup 

Total Exposure 

mg/kg Percent of 

body wt/day Rfd 

------------- ---------------- 0.000678 0.1% 

0 . 000723 0.1% 

0 . 000678 0 .1% 

0.000614 0 . 0% 

0.000716 0.1% 

0.000560 0 . 0% 

0.001990 0.2% 

0.000615 0 . 0% 

0.001274 0.1% 

0.000808 0.1% 

0 .000628 0.1% 

0.000578 0.0% 

0.000584 0.0% 

0.000592 0.0% 

0 . 000528 0.0% 

0 . 001548 0.1% 

0 . 000611 0.0% 

0.001462 0.1% 

0.001208 0.1% 

0.000846 0.1% 

0.000603 0.0% 

0.000623 0.0% 

0.000541 0.0% 

0.000612 0.0% 

Page 9 of 10 
Nicosulfuron Dietary Exposure and Risk Assessment 

PC Code 129008 

Attachment 3. Chronic Results files: Food Alone 

U. S . EPA 

DEEM-FCI D Chron i c ana l y s i s f or NICOSULFURON 

Re sid u e file n ame : C:\Documents a nd Set t ings\MNEGUSSI \My 

3.16\Ni cosu l f u ron\Chr onicFoodAl one_Nicosulf u r on2014.R08 

DP# 417840 

Ver . 3 . 16 , 03 - 08 - d 

NHANES 2003 - 2008 2 - day 

Documents\DEEM v e r sion 

Ad j ustment factor #2 NOT used. 

Ana l y s i s Date 02 - 18- 2014/14: 44:08 

Ref eren ce dose (RfD, Chronic) = 1.25 

COMMENT 1 : Sorg hum use 

Residue fil e dated: 02 - 05 - 2014 /16 : 1 1 :29 

mg/kg bw/day 

Tot al exposure by pop ulation s ubgroup 

Popul ation 

Subgr oup 

Total US Popul a tion 

Hispanic 

No n -Hi sp-Whit e 

No n - Hisp -Black 

No n - Hisp-Other 

Nurs ing Inf ants 

Non - Nursing I nfants 

Female 13+ PREG 

Children 1 - 6 

Chil dren 7-12 

Ma l e 1 3 - 19 

Female 13 - 19/NP 

Ma l e 2 0+ 

Female 2 0+/NP 

Seniors 55+ 

All I n fant s 

Fema le 13 -50 

Ch ild r en 1-2 

Child r en 3 - 5 

Ch i l d ren 6 - 12 

Youth 13-1 9 

Adul ts 2 0 - 49 

Adul ts 50-99 

Femal e 1 3-49 

Tota l Exposure 

mg/k g 

body wt/day 

0.000277 

0.000340 

0.000265 

0.000283 

0. 000254 

0.000197 

0 . 000656 

0.000237 

0 . 000760 

0.000473 

0.000351 

0.000268 

0.0002 10 

0 . 000170 

0 . 000140 

0 . 000514 

0 . 000211 

0 . 00088 2 

0 . 000720 

0 . 000494 

0.0003 10 

0 . 000222 

0.00014 5 

0.000212 

Page 10 of 10 

Pe r cen t o f 

Rf d 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0.1% 

0 . 0 % 

0.1% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0.0% 

0 . 0% 

0.0% 

0.0% 

0. 1% 

0. 1% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0%