Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address 0248 - Malathion (NO INERT USE) Chemical # and Name: 057701 Malathion 12-Aug-2010 GENERIC ID # GDCI-057701-830 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 835.1230 835.4100 835.4300 835.6100 835.6200

850.1010 850.1075 850.1350 Sediment and soil absorption/desorption for parent

and degradates Aerobic soil metabolism Aerobic aquatic metabolism Terrestrial field dissipation Aquatic field dissipation

Aquatic invertebrate acute toxicity, test, freshwater daphnids Fish acute toxicity test, freshwater and marine Mysid chronic toxicity test 0248 - Malathion (NO INERT USE) Chemical # and Name: 057701 Malathion 12-Aug-2010 GENERIC ID # GDCI-057701-830

U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q

U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q EP; PAI; TGAI TGAI or PAIRA TGAI or PAIRA TEP TEP

EP; PAI; TGAI EP; PAI; TGAI TGAI 12 24 24 24 24

12 12 12 1 of Page

(4, 20) (5, 7, 8) (6) (8, 9, 12) (9, 11)

(1, 10, 14) (3, 10, 14) (15, 16, 19) N

N N N N

N N N 2Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 850.1400 850.2100 Fish early-life stage toxicity test

Avian acute oral toxicity test 0248 - Malathion (NO INERT USE) Chemical # and Name: 057701 Malathion 12-Aug-2010 GENERIC ID # GDCI-057701-830

U,HH,J,A,II,K,C,B,Q U,HH,J,A,II,K,C,B,Q TGAI EP; PAI; TGAI 12 12 2 of Page

(15, 17, 18) (2, 13) N

N 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS 0248 - Malathion (NO INERT USE) GDCI-057701-830

1 2 3 4 5 6 7 8 9 10 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The malathion degradate malaoxon should be the test substance. An acute study in daphids is required. The following acute oral studies should be included: Test substance malathion, acute LD50 in Passerine Species; Test Substance malaoxon, acute LD50 in the same passerine species as used for the malathion study. Test substance should be the malathion degradate malaoxon. Acute studies in bluegill sunfish and rainbow trout are required. Test substance should be the malathion degradate malaoxon. Study should measure the same degradates as the respective malathion and malaoxon hydrolysis studies. Study should examine the environmental fate of malathion and its degradates in acidic soil and water conditions (pH of approximately 5.5 to 6.5). Should examine the fate of malathion in acidic soil and water conditions (pH of approximately 5.5 to 6.5). Aerobic soil metabolism data is also required on the malathion degradate malaoxon under the same conditions. Required for aquatic food and nonfood crop uses for aquatic sites that are intermittently dry. Such sites include, but are not limited to cranberry bogs and rice paddies. Only environmental chemistry methods are needed. Malathion and malaoxon should be studied. Freshwater fish LC50 (the most sensitive of the species tested), freshwater invertebrate EC50 (preferably Daphnia), and acute LC50/EC50 estuarine and marine organisms studies using the EP or TEP are required for any product which meets any of the following conditions: (i) The end-use pesticide will be introduced directly into an aquatic environment (e.g., aquatic herbicides and mosquito larvicides) when used as directed; (ii) the maximum expected environmental concentration (MEEC) or the estimated environmental concentration (EEC) in the aquatic environment is Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop J - Forestry use K - Residential Q - Residential outdoor use U - Residential and public access premises HH - Occupational Use Conventional Chemical II - Residential Use Conventional Chemical 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS 0248 - Malathion (NO INERT USE) GDCI-057701-830

11 12

13 14 15

16 17 18 19 20 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

equal to or greater than one-half the LC50 or EC50 of the TGAI when the EP is used as directed; (iii) an ingredient in the end-use formulation other than the active ingredient is expected to enhance the toxicity of the active ingredient or to cause toxicity to aquatic organisms. Environmental chemistry methods used to generate data associated with this study must include results of a successful confirmatory method trial by an independent laboratory. Test standards and procedures for independent laboratory validation are available as addenda to the guideline for this test requirement. Environmental chemistry methods used to generate data associated with this study must include results of a successful confirmatory method trial by an independent laboratory. The environmental chemistry methods must include a statement of no data confidentiality claims, i.e., non-CBI. Test standards and procedures for independent laboratory validation are available as addenda to the guideline for this test requirement. Data using the TGAI are required to support all outdoor end-use product uses including, but not limited to turf. Data are generally not required to support end-use products in the form of a gas, a highly volatile liquid, a highly reactive solid, or a highly corrosive material. Data using the TGAI are required to support all outdoor end-use product uses including turf. Data are generally not required to support end use products in the form of a gas, a highly volatile liquid, a highly reactive solid, or a highly corrosive material. Data are required on estuarine species if the product is: (i) intended for direct application to the estuarine or marine environment; (ii) expected to enter this environment in significant concentrations because of its expected use or mobility patterns, and (iii) if the acute LC50 or EC50 < 1 mg/l; or (iv) if the estimated environmental concentration in water is equal to or greater than 0.01 of the acute EC50 or LC50 and any of the following conditions exist: (a) studies of other organisms indicate the reproductive physiology of fish and/or invertebrates may be affected; (b) physicochemical properties indicate bioaccumulation of the pesticide; (c) the pesticide is persistent in water (e.g., half-life in water greater than 4 days). Data are generally not required for outdoor residential uses, other than turf, unless data indicate that pesticide residues from the proposed use(s) can potentially enter waterways. Data are generally not required for other, non-turf, outdoor residential uses, i.e., gardens and ornamentals. Chronic toxicity study should examine the effects of malathion on estuarine/marine fish. Chronic toxicity study should examine the effect of malathion on estuarine/marine invertebrates. Adsorption and desorption using a batch equilibrium method is preferred. However in some cases, for example, where the pesticide degrades rapidly, soil column leaching with unaged or aged columns may be more appropriate to fully characterize the potential mobility of the parent compound and major transformation products. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE 0248 - Malathion (NO INERT USE) Case # and Name: 1 Page: of 1

4787 CHEMINOVA A/S Co. Nr. Company Name Agent For Company CHEMINOVA INC. 1600 WILSON BLVD., SUITE 700 Address City ZIP ARLINGTON 22209 OMB Approval 2070-0174

State
VA DCI Number: GDCI-057701-830

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf