# Patent

## Title
Modulating X-ray radiation dose in CT scan

## Abstract

A method for modulating x-ray radiation dose in CT scan is disclosed. The method may include: acquiring x-ray attenuation information of each Z position within a planned scanning sequence for a scan region of a subject from data of a finished scanning sequence for the subject; and then, based on the acquired x-ray attenuation information, performing dose modulation with respect to the XY scanning profile at each Z position within the planned scanning sequence. The finished scanning sequence can be an axial and/or helical scanning sequence for a scan region wholly or partially same as the scan region and has been performed earlier. The Z position may include a position in Z direction extending from head to foot of the subject or conversely. The XY scanning profile may include a scanning profile of the subject which is vertical to Z direction.

## Background
The present application claims the priority to Chinese Patent Applications No. 201410665463.X, filed with the Chinese State Intellectual Property Office on Nov. 19, 2014, and Chinese Patent Applications No. 201510785038.9, filed with the Chinese State Intellectual Property Office on Nov. 16, 2015, both of which are incorporated herein by reference in their entireties.
BACKGROUND
The present disclosure relates to CT scan.
NEUSOFT MEDICAL SYSTEMS CO., LTD. (NMS), founded in 1998 with its world headquarters in China, is a leading supplier of medical equipment, medical IT solutions, and healthcare services. NMS supplies medical equipment with a wide portfolio, including CT, MRI, digital X-ray machine, Ultrasound, PET (Positron Emission Tomography), Linear Accelerator, and Biochemistry Analyser. Currently, NMS' products are exported to over 60 countries and regions around the globe, serving more than 5,000 renowned customers. NMS's latest successful developments, such as 128 Multi-Slice CT Scanner System, Superconducting MRI, Linear Accelerator, and PET products, have led China to become a global high-end medical equipment producer. As an integrated supplier with extensive experience in large medical equipment, NMS has been committed to the study of avoiding secondary potential harm caused by excessive X-ray irradiation to the subject (e.g., a patient) during the CT scanning process.



BRIEF DESCRIPTION OF DRAWINGS
Features of the present disclosure are illustrated by way of example and not limited in the following figure(s), in which like numerals indicate like elements, in which:
FIG. 1 is a flowchart of a method for modulating x-ray radiation dose in CT scan according to an example of the present disclosure;
FIG. 2 is a side view of a subject according to an example of the present disclosure;
FIG. 3A and FIG. 3B are side views of a subject according other examples of the present disclosure;
FIG. 4 illustrates a schematic flowchart of a method for modulating x-ray radiation dose in CT scan according to an example of the present disclosure in which a planned scanning sequence goes beyond the range of a finished scanning sequence and has no abrupt change of a subject region in the Z-direction;
FIG. 5 schematically illustrates a slice data in an example of the present disclosure;
FIG. 6A schematically illustrates a diagram of modulating x-ray radiation dose of an equivalent water phantom in an example of the present disclosure;
FIG. 6B illustrates the curve of modulated x-ray radiation dose corresponding to the equivalent water phantom in FIG. 6A;
FIG. 7A schematically illustrates a diagram of modulating x-ray radiation dose of an equivalent water phantom in another example of the present disclosure;
FIG. 7B illustrates the curve of modulated x-ray radiation dose corresponding to the equivalent water phantom in FIG. 7A;
FIG. 8 schematically illustrates hardware structure of a device for modulating x-ray radiation dose in CT scan according to an example of the present disclosure; and
FIG. 9 schematically illustrates corresponding functional modules of a control logic which corresponds to the method for modulating x-ray radiation dose in CT scan as shown in FIG. 1 according to an example of the present disclosure.



DETAILED DESCRIPTION
For simplicity and illustrative purposes, the present disclosure is described by referring mainly to an example thereof. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present disclosure. It will be readily apparent however, that the present disclosure may be practiced without limitation to these specific details. In other instances, some methods and structures have not been described in detail so as not to unnecessarily obscure the present disclosure. As used herein, the terms “a” and “an” are intended to denote at least one of a particular element, the term “includes” means includes but not limited to, the term “including” means including but not limited to, and the term “based on” means based at least in part on.
Computed Tomography (CT) is a widely used medical technology, in which, however, different methods for modulating x-ray radiation dose may directly influence the quality of a reconstructed CT image, and may even cause serious damages to the subject due to excessive irradiation.
Usually, for a method for modulating x-ray radiation dose in CT scan, according to the physical size or profile of a subject and information about X-ray attenuation at different positions in Z direction (an anatomically defined vertical axis), the scan slices of the subject at different positions in Z direction may be approximated as an ellipse, wherein the length ratio between the long axis and the short axis of the ellipse may be set empirically. However, due to factors such as individual difference of subjects, the above approximation may be inaccurate and lead to an excessive or excessively small dose, which may negatively influence the quality of the reconstructed CT image or even cause severe damages to the subjects due to excessive irradiation.
FIG. 1 is a flowchart illustrating a method for modulating x-ray radiation dose in CT scan according to an example of the present disclosure. The method may include the following block 101.
At block 101, x-ray attenuation information for each of different projection angles of the XY scanning profile at each of different Z positions within a planned scanning sequence with respect to a scan region of a subject may be acquired. The x-ray attenuation information can be acquired from data of a finished scanning sequence of the subject, and the x-ray radiation dose for each projection angle of the XY scanning profile at each Z position within the planned scanning sequence may be modulated according to the acquired x-ray attenuation information, wherein, Z position may include a position in Z direction from head to foot of the subject or conversely, and the XY scanning profile may include a scanning profile of the subject which is vertical to Z direction.
In examples of the present disclosure, the x-ray attenuation information of a planned scanning sequence for current scan region of a subject may be acquired from data of some finished axial and/or helical scanning sequence of the subject, and a x-ray radiation dose modulation with respect to the XY scanning profile at each of Z positions within the planned scanning sequence may be performed based on the acquired x-ray attenuation information. The finished axial and/or helical scanning sequence may include the axial and/or helical scanning sequence for the same scan region of the same subject which has been finished before the current time, and may be referred to as “finished scanning sequence” hereinafter. As long as the x-ray attenuation information with respect to the scan region of the subject is acquired, an x-ray dose modulation may be performed based on the x-ray attenuation information. This may guarantee noise consistency between reconstructed CT images for different scan regions of a same subject.
In examples of the present disclosure, the planned scanning sequence may be within or beyond the range of the finished scanning sequence. The following description of a method for modulating x-ray radiation dose in CT scan is given with respect to these two different relationships between the planned scanning sequence and the finished scanning sequence respectively.
FIG. 2 illustrates a side view of a subject. When the range of the planned scanning sequence is within the range of the finished scanning sequence, the x-ray attenuation information for each of different projection angles of the XY scanning profile at each of different Z positions within the planned scanning sequence may be acquired based on a corresponding relationship between the finished scanning sequence and the planned scanning sequence, and then an x-ray dose modulation may be performed based on the acquired x-ray attenuation information.
Particularly, if the range of the planned scanning sequence is within the range of the finished scanning sequence, a x-ray radiation dose Imod,zi,j for the jth projection angle of the XY scanning profile at a Z position zi within the planned scanning sequence may be calculated according to the following equation:




  
    
      
        
          I
          
            mod
            ,
            zi
            ,
            j
          
        
        =
        
          
            
              M
              ·
              
                I
                
                  mod
                  ,
                  zi
                  ,
                  start
                
              
            
            
              
                ∑
                
                  j
                  =
                  1
                
                M
              
              ⁢
              
                
                  A
                  
                    max
                    ,
                    zi
                    ,
                    j
                  
                
              
            
          
          ·
          
            
              A
              
                max
                ,
                zi
                ,
                j
              
            
          
        
      
    
    
      
        (
        1
        )
      
    
  




wherein, Imod,zi,start represents an initial x-ray radiation dose of Z position zi, which may be calculated through equation (17) described below,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi in the data of the finished scanning sequence, and represents the maximum of the x-ray attenuation values which are calculated based on the X-ray attenuation signals detected by each of the detection channels of the CT scanner respectively.
FIG. 3A and FIG. 3B illustrate side views of a subject, and a difference between FIG. 3A and FIG. 3B is: in FIG. 3A, when pilot image data of the planned scanning sequence does not have any abrupt change in Z direction; and in FIG. 3B, when pilot image data of the planned scanning sequence may have an abrupt change in Z direction such as from neck to shoulder or conversely. When the range of the planned scanning sequence goes beyond the range of the finished scanning sequence, it is to further determine whether the pilot image data of the planned scanning sequence may have an abrupt change in Z direction. The following description is mainly directed to a case where the pilot image data of the planned scanning sequence has no abrupt change in Z direction.
Specifically, when the range of the planned scanning sequence goes beyond the range of the finished scanning sequence and the pilot image data of the planned scanning sequence has no abrupt change in Z direction, referring to FIG. 4, operation(s) described in block 101 shown in FIG. 1 can be performed. FIG. 4 illustrates, in some examples in accordance with the present disclosure, block 101 can comprise the following blocks 401 and 402.
At block 401, shape ratio information of the XY scanning profile at each of different Z positions within an overlapping sequence may be acquired, and then, according to the acquired shape ratio information, it may be determined whether the XY scanning profiles at different Z positions within the overlapping sequence are similar to each other or not, wherein the overlapping sequence represents a part of the planned scanning sequence which is overlapped with the finished scanning sequence.
For example, by calculating the x-ray attenuation information for each of the different projection angles of the XY scanning profile at each of Z positions within the overlapping sequence, the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence may be acquired according to the calculated x-ray attenuation information; and then, according to the acquired shape ratio information, it may be determined whether the XY scanning profiles at different Z positions are similar each other or not, and if yes, a x-ray dose modulation may be performed subsequently, and if not, the procedure not perform the x-ray does modulation.
In an example, according to the x-ray attenuation information of the overlapping sequence (including the x-ray attenuation information for each of different projection angles of the XY scanning profile at each of Z positions) acquired from the data of the finished scanning sequence, the equivalent circular water phantom at each of Z positions within the overlapping sequence may be converted into an equivalent elliptical water phantom of the same area.
For any Z position, the following equation may hold:




  
    
      
        
          S
          
            Circle
            ,
            pzi
          
        
        =
        
          
            π
            ·
            
              
                (
                
                  
                    D
                    zi
                  
                  /
                  2
                
                )
              
              2
            
          
          =
          
            
              π
              ·
              
                
                  a
                  
                    Ellipse
                    ,
                    pzi
                  
                
                2
              
              ·
              
                
                  b
                  
                    Ellipse
                    ,
                    pzi
                  
                
                2
              
            
            =
            
              S
              
                Ellipse
                ,
                pzi
              
            
          
        
      
    
    
      
        (
        2
        )
      
    
  




wherein, SCircle,pzi represents an area of the equivalent circular water phantom at the ith Z position Pzi within the overlapping sequence,
SEllipse,pzi represents an area of the equivalent elliptical water phantom at the ith Z position Pzi within the overlapping sequence,
Dzi represents the diameter of the equivalent circular water phantom at the ith Z position Pzi within the overlapping sequence, which can be calculated through equation (18) described below,
aEllipse,pzi and bEllipse,pzi respectively represent a length of the long axis and a short axis of the equivalent elliptical water phantom at the ith Z position Pzi within the overlapping sequence. In some examples, length of the long axis aEllipse,pzi may be set according to the maximum of water phantom x-ray attenuation values which are converted from the x-ray attenuation value for each of different projection angles of the XY scanning profile at the ith Z position Pzi in the data of the finished scanning sequence, and length of the short axis bEllipse,pzi can be calculated through the above equation (2).
The shape ratio information δpzi of the XY scanning profile at the ith Z position Pzi may be acquired by calculating the ratio between the long axis and the short axis of the equivalent elliptical water phantom at the ith Z position Pzi. For example, it may be calculated through the following equation (3).




  
    
      
        
          δ
          pzi
        
        =
        
          
            a
            
              Ellipse
              ,
              pzi
            
          
          
            b
            
              Ellipse
              ,
              pzi
            
          
        
      
    
    
      
        (
        3
        )
      
    
  




By calculating an arithmetic mean for the shape ratio information δpzi of the XY scanning profile at each of all Z positions Pzi within the overlapping sequence, i.e., substituting the equation (3) into the following equation (4), a mean shape ratio information δmean of the overlapping sequence may be acquired:




  
    
      
        
          δ
          mean
        
        =
        
          
            1
            NumZ
          
          ⁢
          
            
              ∑
              
                i
                =
                1
              
              NumZ
            
            ⁢
            
              δ
              pzi
            
          
        
      
    
    
      
        (
        4
        )
      
    
  




wherein, i=1, 2, . . . NumZ, NumZ represents a quantity of all Z positions within the overlapping sequence.
By calculating a variance with the shape ratio information δpzi of the XY scanning profile at each of all Z positions Pzi within the overlapping sequence and the mean shape ratio information δmean of the overlapping sequence, i.e., substituting the equations (3) and (4) into the following equation (5), a variance regarding shape ratio information D1 of the overlapping sequence can be calculated:




  
    
      
        
          
            D
            ⁢
            
              
            
            ⁢
            1
          
          =
          
            
              1
              NumZ
            
            ⁢
            
              
                ∑
                
                  i
                  =
                  1
                
                NumZ
              
              ⁢
              
                
                  (
                  
                    
                      δ
                      pzi
                    
                    -
                    
                      δ
                      mean
                    
                  
                  )
                
                2
              
            
          
        
        ,
        
          i
          =
          1
        
        ,
        2
        ,
        
          ...
          ⁢
          
            
          
          ⁢
          NumZ
        
      
    
    
      
        (
        5
        )
      
    
  




If the variance regarding shape ratio information D1 of the overlapping sequence is larger than a preset threshold value T1, it may be determined that the XY scanning profiles at different Z positions within the overlapping sequence are not similar and the supposed subsequent operation may be omitted. If the variance regarding shape ratio information D1 is equal or less than the threshold value T1, it may be determined that the XY scanning profiles at different Z positions within the overlapping sequence are similar, wherein, the threshold value T1 may be set arbitrarily according to practical application scenarios.
Based on the above, block 401 may include:
converting the equivalent circular water phantom for the XY scanning profile at each of Z positions within the overlapping sequence into an equivalent elliptical water phantom of the same area;
calculating, with the above equation (3), the length ratio between the long axis and the short axis of the equivalent elliptical water phantom at each of Z positions within the overlapping sequence, as the shape ratio information δpzi of the XY scanning profile at each of Z positions within the overlapping sequence;
calculating, with the above equations (4) and (5), the variance regarding shape ratio information D1 of the overlapping sequence; and
determining whether the variance regarding shape ratio information D1 is larger than a preset threshold value T1, and if yes, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are not similar; and if no, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are similar.
In other examples, since the x-ray attenuation value at each of Z positions zi mainly depends on the shape and x-ray attenuation coefficient of the XY scanning profile at Z position zi, the x-ray attenuation deviation of each of Z positions zi with respect to the whole overlapping sequence may be calculated as the shape ratio information of the XY scanning profile at Z position zi. For example, for any Z position zi within the overlapping sequence, by calculating an arithmetic mean for the absolute value of the difference between a maximum x-ray attenuation value for each of the projection angles at Z position zi and the mean maximum x-ray attenuation value for corresponding projection angle of the whole overlapping sequence, an x-ray attenuation deviation of Z position zi with respect to the whole overlapping sequence may be acquired.
Further, the maximum x-ray attenuation value for each of the projection angles may be normalized so as to simplify related calculations. For example, for any Z position zi within the overlapping sequence, the maximum x-ray attenuation value for each of the projection angles may be normalized by the maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zi or the diameter of the equivalent circular water phantom for the XY scanning profile at Z position zi, and thus a normalized x-ray attenuation value for each of the projection angles of the XY scanning profile at Z position zi may be acquired.
Specifically, according to an example, a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence may be acquired from data of the finished scanning sequence, a maximum x-ray attenuation value in pilot image scanning PAmax,zi of the XY scanning profile at each of Z positions zi may be acquired from pre-acquired pilot image data of the subject, and then a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence may be normalized by a maximum x-ray attenuation value in pilot image scanning PAmax,zi of the XY scanning profile at each of Z positions zi, so as to acquire a normalized x-ray attenuation value Cmod,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence, specifically expressed as follows:




  
    
      
        
          C
          
            mod
            ,
            zi
            ,
            j
          
        
        =
        
          
            A
            
              max
              ,
              zi
              ,
              j
            
          
          
            PA
            
              max
              ,
              zi
            
          
        
      
    
    
      
        (
        6
        )
      
    
  




wherein, i=1, 2, . . . NumZ, j=1, 2 . . . M,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at the ith Z position zi within the overlapping sequence,
Pmax,zi represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at the ith Z position zi and may be determined from pre-acquired pilot image data of the subject,
NumZ represents a quantity of Z positions within the overlapping sequence, and i represents an index number of the ith Z position, and
M represents a quantity of projection angles, and j represents an index number of the jth projection angle.
By calculating an arithmetic mean for the normalized x-ray attenuation value Cmax,zi,j for the jth projection angle of each of Z positions zi within the overlapping sequence, a mean normalized x-ray attenuation value Cmod,j for the jth projection angle of the overlapping sequence may be acquired, specifically expressed as follows:




  
    
      
        
          
            C
            
              mod
              ,
              j
            
          
          _
        
        =
        
          
            
              ∑
              
                i
                =
                1
              
              NumZ
            
            ⁢
            
              C
              
                mod
                ,
                zi
                ,
                j
              
            
          
          NumZ
        
      
    
    
      
        (
        7
        )
      
    
  




By calculating an arithmetic mean for the absolute value of the difference between the normalized x-ray attenuation value Cmax,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence and the mean normalized x-ray attenuation value Cmod,j for the corresponding projection angle of the overlapping sequence, an x-ray attenuation deviation ΔCmod,zi of each of Z positions zi within the overlapping sequence may be acquired, specifically expressed as follows:




  
    
      
        
          Δ
          ⁢
          
            
          
          ⁢
          
            C
            
              mod
              ,
              zi
            
          
        
        =
        
          
            
              ∑
              
                j
                =
                1
              
              M
            
            ⁢
            
              
              
                
                  C
                  
                    mod
                    ,
                    zi
                    ,
                    j
                  
                
                -
                
                  
                    C
                    
                      mod
                      ,
                      j
                    
                  
                  _
                
              
              
            
          
          M
        
      
    
    
      
        (
        8
        )
      
    
  




By calculating an arithmetic mean for the x-ray attenuation deviation ΔCmod,zi of each of Z positions zi within the overlapping sequence, a mean x-ray attenuation deviation ΔCmean of the overlapping sequence may be acquired, specifically expressed as follows:




  
    
      
        
          Δ
          ⁢
          
            
          
          ⁢
          
            C
            mean
          
        
        =
        
          
            1
            NumZ
          
          ⁢
          
            
              ∑
              
                i
                =
                1
              
              NumZ
            
            ⁢
            
              Δ
              ⁢
              
                
              
              ⁢
              
                C
                
                  mod
                  ,
                  zi
                
              
            
          
        
      
    
    
      
        (
        9
        )
      
    
  




By calculating a variance with the x-ray attenuation deviation ΔCmod,zi of each of Z positions zi within the overlapping sequence and the mean x-ray attenuation deviation ΔCmean of the overlapping sequence, that is, substituting the equations (8) and (9) into the following equation (10), a variance regarding x-ray attenuation deviation D2 of the overlapping sequence may be acquired:




  
    
      
        
          
            D
            ⁢
            
              
            
            ⁢
            2
          
          =
          
            
              1
              NumZ
            
            ⁢
            
              
                ∑
                
                  i
                  =
                  1
                
                NumZ
              
              ⁢
              
                
                  (
                  
                    
                      Δ
                      ⁢
                      
                        
                      
                      ⁢
                      
                        C
                        
                          mod
                          ,
                          zi
                        
                      
                    
                    -
                    
                      Δ
                      ⁢
                      
                        
                      
                      ⁢
                      
                        C
                        mean
                      
                    
                  
                  )
                
                2
              
            
          
        
        ,
        
          

        
        ⁢
        
          i
          =
          1
        
        ,
        2
        ,
        
          ...
          ⁢
          
            
          
          ⁢
          
            Num
            ⁢
            Z
          
        
        ,
        
          j
          =
          1
        
        ,
        2
        ,
        
          ...
          ⁢
          
            
          
          ⁢
          M
        
      
    
    
      
        (
        10
        )
      
    
  




If the variance regarding x-ray attenuation deviation D2 of the overlapping sequence is larger than a preset threshold value T2, it may be determined that the XY scanning profiles at different Z positions within the overlapping sequence are not similar and the supposed subsequent operation can be omitted. If the variance regarding x-ray attenuation deviation D2 of the overlapping sequence is equal or less than the threshold value T2, it may be determined that the XY scanning profiles at different Z positions within the overlapping sequence are similar. The threshold value T2 may be set arbitrarily according to practical application scenarios.
Based on the above, block 401 may include:
acquiring, from data of the finished scanning sequence, a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence,
acquiring, from pilot image data acquired beforehand, a maximum x-ray attenuation value PAmax,zi of the XY scanning profile at each of Z positions zi in pilot image scanning,
normalizing, according to the above equation (6), a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence with a maximum x-ray attenuation value in pilot image scanning PAmax,zi of the XY scanning profile at each of Z positions zi, so as to acquire a normalized x-ray attenuation value Cmod,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence;
calculating, according to the above equations (7) and (8), the x-ray attenuation deviation ΔCmod,zi of each of Z positions zi within the overlapping sequence with the normalized x-ray attenuation value Cmod,z,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence;
calculating, according to the equations (9) and (10), the mean x-ray attenuation deviation ΔCmean of the overlapping sequence and the variance regarding x-ray attenuation deviation D2 of the overlapping sequence, with the x-ray attenuation deviation ΔCmod,zi of each of Z positions zi within the overlapping sequence; and
determining whether the variance regarding x-ray attenuation deviation D2 of the overlapping sequence is larger than a preset second threshold value T2, and if yes, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are not similar, and if no, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are similar.
According to another example of the present disclosure, a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile in each of Z positions zi within the overlapping sequence may be acquired from data of the finished scanning sequence, the diameter Dzi of the equivalent circular water phantom at each of Z positions zi within the overlapping sequence may be acquired from pilot image data obtained by a pilot image scanning beforehand, and then a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence may be normalized by the diameter Dzi of the equivalent circular water phantom at each of Z positions zi within the overlapping sequence, so as to acquire a normalized x-ray attenuation value Bmod,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence, specifically expressed as follows:




  
    
      
        
          B
          
            mod
            ,
            zi
            ,
            j
          
        
        =
        
          
            A
            
              max
              ,
              zi
              ,
              j
            
          
          
            D
            Zi
          
        
      
    
    
      
        (
        11
        )
      
    
  




wherein, 1=1, 2 . . . NumZ, j=1, 2 . . . M,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at the ith Z position zi within the overlapping sequence,
Dzi represents the diameter of the equivalent circular water phantom of the XY scanning profile at the ith Z position zi within the overlapping sequence and may be calculated according to equation (18) described below;
NumZ represents a quantity of Z positions within the overlapping sequence, and i represents an index number of the ith Z position, and
M represents a quantity of projection angles, and j represents an index number of the jth projection angle.
By calculating an arithmetic mean for the normalized x-ray attenuation value Bmod,zi,j for the jth projection angle of each of Z positions zi within the overlapping sequence, a mean normalized x-ray attenuation value Bmod,j for the jth projection angle of the overlapping sequence may be acquired, specifically expressed as follows:




  
    
      
        
          
            B
            
              mod
              ,
              j
            
          
          _
        
        =
        
          
            
              ∑
              
                i
                =
                1
              
              NumZ
            
            ⁢
            
              B
              
                mod
                ,
                zi
                ,
                j
              
            
          
          NumZ
        
      
    
    
      
        (
        12
        )
      
    
  




By calculating an arithmetic mean for the absolute value of the difference between the normalized x-ray attenuation value Bmod,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence and the mean normalized x-ray attenuation value Bmod,j for the corresponding projection angle of the overlapping sequence, an x-ray attenuation deviation ΔBmod,zi of each of Z positions zi within the overlapping sequence may be acquired, specifically expressed as follows:




  
    
      
        
          Δ
          ⁢
          
            
          
          ⁢
          
            B
            
              mod
              ,
              zi
            
          
        
        =
        
          
            
              ∑
              
                j
                =
                1
              
              M
            
            ⁢
            
              
              
                
                  B
                  
                    mod
                    ,
                    zi
                    ,
                    j
                  
                
                -
                
                  
                    B
                    
                      mod
                      ,
                      j
                    
                  
                  _
                
              
              
            
          
          M
        
      
    
    
      
        (
        13
        )
      
    
  




By calculating an arithmetic mean for the x-ray attenuation deviation ΔBmod,zi of each of Z positions zi within the overlapping sequence, a mean x-ray attenuation deviation ΔBmean of the overlapping sequence may be acquired, specifically expressed as follows:




  
    
      
        
          Δ
          ⁢
          
            
          
          ⁢
          
            B
            mean
          
        
        =
        
          
            1
            NumZ
          
          ⁢
          
            
              ∑
              
                i
                =
                1
              
              NumZ
            
            ⁢
            
              Δ
              ⁢
              
                
              
              ⁢
              
                B
                
                  mod
                  ,
                  zi
                
              
            
          
        
      
    
    
      
        (
        14
        )
      
    
  




By calculating a variance with the x-ray attenuation deviation ΔBmod,zi of each of Z positions zi within the overlapping sequence and the mean x-ray attenuation deviation ΔBmean of the overlapping sequence, that is, substituting the equations (13) and (14) into the following equation (15), a variance regarding x-ray attenuation deviation D3 of the overlapping sequence may be acquired:




  
    
      
        
          
            D
            ⁢
            
              
            
            ⁢
            3
          
          =
          
            
              1
              NumZ
            
            ⁢
            
              
                ∑
                
                  i
                  =
                  1
                
                NumZ
              
              ⁢
              
                
                  (
                  
                    
                      Δ
                      ⁢
                      
                        
                      
                      ⁢
                      
                        B
                        
                          mod
                          ,
                          zi
                        
                      
                    
                    -
                    
                      Δ
                      ⁢
                      
                        
                      
                      ⁢
                      
                        B
                        mean
                      
                    
                  
                  )
                
                2
              
            
          
        
        ,
        
          

        
        ⁢
        
          i
          =
          1
        
        ,
        2
        ,
        
          ...
          ⁢
          
            
          
          ⁢
          NumZ
        
        ,
        
          j
          =
          1
        
        ,
        2
        ,
        
          ...
          ⁢
          
            
          
          ⁢
          M
        
      
    
    
      
        (
        15
        )
      
    
  




If the variance regarding x-ray attenuation deviation D3 of the overlapping sequence is larger than a preset threshold value T3, it may be determined that the XY scanning profiles at different Z positions within the overlapping sequence are not similar and the supposed subsequent operation may be omitted. If the variance regarding x-ray attenuation deviation D3 of the overlapping sequence is equal or less than the threshold value T3, it may be determined that the XY scanning profiles at different Z positions within the overlapping sequence are similar. The threshold value T3 may be set arbitrarily according to practical application scenarios.
Based on the above, block 401 may include:
acquiring, from data of the finished scanning sequence, a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence,
acquiring, from pilot image data acquired beforehand, the diameter Dzi of the equivalent circular water phantom at each of Z positions zi within the overlapping sequence,
normalizing, according to the above equation (11), a maximum x-ray attenuation value Amax,zi,j for each of the projection angles j of the XY scanning profile at each of Z positions zi within the overlapping sequence, so as to acquire a normalized x-ray attenuation value Bmod,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence;
calculating, according to the above equations (12) and (13), the x-ray attenuation deviation ΔBmod,zi of each of Z positions zi within the overlapping sequence with the normalized x-ray attenuation value Bmod,zi,j for each of the projection angles of the XY scanning profile at each of Z positions zi within the overlapping sequence;
calculating, with the x-ray attenuation deviation ΔBmod,zi of each of Z positions zi within the overlapping sequence, according to the equations (14) and (15), the mean x-ray attenuation deviation ΔBmean of the overlapping sequence and the variance regarding x-ray attenuation deviation D3 of the overlapping sequence; and
determining whether the variance regarding x-ray attenuation deviation D3 of the overlapping sequence is larger than a preset third threshold value T3, and if yes, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are not similar, and if no, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are similar.
At block 402, if it is determined that the XY scanning profiles at different Z positions within the overlapping sequence are similar to each other, a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence may be acquired from data of the finished scanning sequence, and the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence may be determined correspondingly.
According to an example, first, a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence may be acquired from data of the finished scanning sequence; and then, according to the acquired maximum x-ray attenuation values, the x-ray radiation dose Imod,j for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence may be determined.
Specifically, the x-ray radiation dose Imod,zi,j for the jth projection angle of the XY scanning profile at a Z position zi within the planned scanning sequence may be calculated according to the following equation:




  
    
      
        
          I
          
            mod
            ,
            zi
            ,
            j
          
        
        =
        
          {
          
            
              
                
                  
                    T
                    max
                  
                  ,
                
              
              
                
                  
                    mod
                    ⁢
                    
                      
                    
                    ⁢
                    v
                  
                  ≥
                  
                    T
                    max
                  
                
              
            
            
              
                
                  
                    
                      mod
                      ⁢
                      
                        
                      
                      ⁢
                      v
                    
                    =
                    
                      
                        
                          M
                          ·
                          
                            I
                            
                              mod
                              ,
                              zi
                              ,
                              start
                            
                          
                        
                        
                          
                            ∑
                            
                              j
                              =
                              1
                            
                            M
                          
                          ⁢
                          
                            
                              A
                              
                                max
                                ,
                                zi
                                ,
                                j
                              
                            
                          
                        
                      
                      ·
                      
                        
                          A
                          
                            max
                            ,
                            zi
                            ,
                            j
                          
                        
                      
                    
                  
                  ,
                
              
              
                
                  
                    T
                    min
                  
                  ≤
                  
                    mod
                    ⁢
                    
                      
                    
                    ⁢
                    v
                  
                  ≤
                  
                    T
                    max
                  
                
              
            
            
              
                
                  
                    T
                    min
                  
                  ,
                
              
              
                
                  
                    mod
                    ⁢
                    
                      
                    
                    ⁢
                    v
                  
                  ≤
                  
                    T
                    min
                  
                
              
            
          
        
      
    
    
      
        (
        16
        )
      
    
  




wherein, Imod,zi,start represents the initial x-ray radiation dose corresponding to Z position zi,
M represents a quantity of projection angles, j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi,
Tmax and Tmin represent a maximum x-ray dose threshold value and a minimum x-ray dose threshold value respectively, and
mod ν represents an x-ray intermediate value for comparing with Tmax and Tmin to determine the Imod,zi,j.
According to an example, when a Z position zin within the planned scanning sequence is within the overlapping sequence too, a maximum x-ray attenuation value Amax,zi,j for the jth projection angle of the XY scanning profile at Z position zin may be directly acquired from data of the finished scanning sequence. However, when a Z position zout within the planned scanning sequence is beyond the overlapping sequence, a maximum x-ray attenuation value Amax,zout,j for the jth projection angle of the XY scanning profile at Z position zout may be predicted from the x-ray attenuation information in pilot image scanning of the XY scanning profile at Z position zout and the x-ray attenuation information of the XY scanning profile at another Z position zout−1 which is closest to the position zout, specifically as follows:




  
    
      
        
          A
          
            max
            ,
            zout
            ,
            j
          
        
        =
        
          
            A
            
              max
              ,
              
                zout
                -
                1
              
              ,
              j
            
          
          ⁢
          
            
              PA
              
                max
                ,
                zout
              
            
            
              PA
              
                max
                ,
                
                  zout
                  -
                  1
                
              
            
          
        
      
    
    
      
        (
        
          16
          ⁢
          
            -
          
          ⁢
          1
        
        )
      
    
  




wherein, Amax,zout,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout;
Amax,zout-1,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout−1, which may be directly acquired from data of the finished scanning sequence or predicted using the above equation (16-1);
PAmax,zout represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout and may be determined from pre-acquired pilot image data of the subject;
PAmax,zout-1 represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout−1 and may be determined from pre-acquired pilot image data of the subject.
According to an example, supposing the diameter of the equivalent circular water phantom at Z position zi within the planned scanning sequence is Dscan,zi, and the diameter of the reference equivalent water phantom of the CT scanner system is Dref, the initial x-ray radiation dose Imod,zi,start of Z position zi may be determined by searching a table of x-ray dose recommendation function based on Dscan,zi and Dref.
In other words, the initial radiation x-ray dose Imod,zi,start may be set according to the following equation:

Imod,zi,start=ƒ(Dscan,zi,Dref)  (17)

wherein, ƒ(Dscan,zi,Dref) is a x-ray dose recommendation function;
Dscan,zi represents the diameter of the equivalent circular water phantom at Z position zi within the planned scanning sequence, which may be calculated through the following equation (18);
Dref represents the diameter of the reference equivalent water phantom of the CT scanner system.
According to an example, a maximum x-ray dose threshold value Tmax and a minimum x-ray dose threshold value Tmin may be determined as follows.
Firstly, before block 101, a pilot image scanning is performed on the subject so as to acquire pilot image data of the subject, and then according to the acquired pilot image data, the diameter of the equivalent circular water phantom at each of Z positions may be determined. Wherein, the pilot image data of the subject usually comprises multiple sets of slice data. In other words, the XY scanning profile at each of Z positions corresponds to a set of slice data, and the diameter of the equivalent circular water phantom at Z position may be calculated with the set of slice data.
Referring to the schematic diagram of slice data as shown in FIG. 5, if a set of slice data is:

{μ1l1,μ2l2, . . . μili}, i=1,2,3, . . . ,N, 

wherein, μi represents the mean x-ray attenuation coefficient of the ith detection channel,
li, represents the length of the x-ray attenuation path in the ith detection channel,
N represents a quantity of detection channels for the CT scanner system.
Then the diameter of the equivalent circular water phantom corresponding to the set of slice data may be calculated through the following equation:




  
    
      
        
          D
          water
        
        =
        
          
            2
            
              μ
              water
            
          
          ·
          
            
              S
              π
            
          
        
      
    
    
      
        (
        18
        )
      
    
  




wherein, μwater represents the x-ray attenuation coefficient of water,
S represents the x-ray attenuation area of the equivalent circular water phantom corresponding to the set of slice data.
According to an example, the x-ray attenuation area S of the equivalent circular water phantom corresponding to a set of slice data may be calculated as follows:




  
    
      
        S
        =
        
          
            ∑
            
              i
              =
              1
            
            N
          
          ⁢
          
            
              
                (
                
                  
                    
                      μ
                      i
                    
                    ⁢
                    
                      l
                      i
                    
                  
                  +
                  
                    
                      μ
                      
                        i
                        +
                        1
                      
                    
                    ⁢
                    
                      l
                      
                        i
                        +
                        1
                      
                    
                  
                
                )
              
              ·
              Δ
            
            ⁢
            
              /
            
            ⁢
            2
          
        
      
    
    
      
        (
        19
        )
      
    
  
  
    
      
        Δ
        =
        
          R
          ·
          
            θ
            N
          
          ·
          
            g
            ⁡
            
              (
              
                
                  h
                  bed
                
                ,
                
                  h
                  center
                
              
              )
            
          
        
      
    
    
      
        (
        
          19
          ⁢
          
            -
          
          ⁢
          1
        
        )
      
    
  




wherein, Δ represents the distance between the centres of adjacent detection units (detectors),
R represents the radius of rotation,
θ represents the sector angle formed between the detection units and the bulb tube,
N represents a quantity of detection channels for the CT scanner system,
hbed represents the distance between the scanning bed and the floor,
hcenter represents the distance between the centre of rotation and the floor;
g(hbed,hcenter) represents a function for modifying Δ. When the subject is located at the centre of rotation, g(hbed,hcenter)=1; when the subject is located above the centre of rotation, g(hbed,hcenter)<1; and when the subject is located below the centre of rotation, g(hbed,hcenter)>1. The specific value of g(hbed,hcenter) may be obtained by searching the table of modification function.
Then, for the diameters of equivalent circular water phantom calculated from multiple sets of slice data which is contained in the pilot image data of the subject, a maximum and a minimum of them are respectively selected as a maximum equivalent circular water phantom diameter Dmax and a minimum equivalent circular water phantom diameter Dmin respectively, and Z position of the XY scanning profile having a maximum equivalent circular water phantom diameter Dmax (hereafter referred as “maximum profile position Pmax”) and Z position Pmin of the XY scanning profile having a minimum equivalent circular water phantom diameter Dmin (hereafter referred as “minimum profile position Pmin”) are determined correspondingly.
Next, the equivalent circular water phantom at a maximum profile position Pmax may be converted into an equivalent water phantom of the same area, and the equivalent circular water phantom at a minimum profile position Pmin may be converted into an equivalent water phantom of the same area also.
According to an example, with the above equation (19), the x-ray attenuation area S1 of the equivalent circular water phantom at a maximum profile position Pmax may be calculated based on the slice data which is contained in the pilot image data of the subject which corresponds to a maximum profile position Pmax. Similarly, based on the slice data corresponding to a minimum profile position Pmin, an x-ray attenuation area S2 of the equivalent circular water phantom at a minimum profile position Pmin may be calculated with the equation (19).
Further, after calculating the x-ray attenuation area S1 of the equivalent circular water phantom at the maximum profile position Pmax and the x-ray attenuation area S2 of the equivalent circular water phantom at the minimum profile position Pmin, the equivalent circular water phantom at the maximum profile position Pmax may be converted into an equivalent elliptical water phantom of the same area, and the equivalent circular water phantom at the minimum profile position Pmax may be converted into an equivalent elliptical water phantom of the same area.
For example, supposing a1 and b1 represent the long axis and the short axis of the equivalent elliptical water phantom at the maximum profile position Pmax respectively, and supposing a2 and b2 represent the long axis and the short axis of the equivalent elliptical water phantom at the minimum profile position Pmin respectively, according to the area equivalent principle (i.e., the equivalent circular water phantom and the equivalent elliptical water phantom are of the same area), the following equations may hold:




  
    
      
        
          S
          ⁢
          
            
          
          ⁢
          1
        
        =
        
          
            π
            4
          
          ⁢
          a
          ⁢
          
            
          
          ⁢
          
            1
            ·
            b
          
          ⁢
          
            
          
          ⁢
          1
        
      
    
    
      
        (
        20
        )
      
    
  
  
    
      
        
          S
          ⁢
          
            
          
          ⁢
          2
        
        =
        
          
            π
            4
          
          ⁢
          a
          ⁢
          
            
          
          ⁢
          
            2
            ·
            b
          
          ⁢
          
            
          
          ⁢
          2
        
      
    
    
      
        (
        21
        )
      
    
  
  
    
      
        
          δ
          mean
        
        =
        
          
            
              a
              ⁢
              
                
              
              ⁢
              1
            
            
              b
              ⁢
              
                
              
              ⁢
              1
            
          
          =
          
            
              a
              ⁢
              
                
              
              ⁢
              2
            
            
              b
              ⁢
              
                
              
              ⁢
              2
            
          
        
      
    
    
      
        (
        22
        )
      
    
  




wherein, δmean may be calculated through the above equation (4).
As a1 and b1 may be calculated through the equations (20) and (22), and a2 and b2 may be calculated through the equations (21) and (22), the equivalent circular water phantom at the maximum profile position Pmax may be converted into an equivalent elliptical water phantom having a long axis of a1 and a short axis of b1, and the equivalent circular water phantom at the minimum profile position Pmin may be converted into an equivalent elliptical water phantom having a long axis of a2 and a short axis of b2, as shown in FIG. 6A.
According to another example, the x-ray attenuation value for each of the projection angles j at the maximum profile position Pmax may be utilized to define an equivalent water phantom having a same area with the equivalent circular water phantom at the maximum profile position Pmax, and the x-ray attenuation value for each of the projection angles j at the minimum profile position Pmin may be utilized to define an equivalent water phantom having a same area with the equivalent circular water phantom at the minimum profile position Pmin, as shown in FIG. 7A.
For example, the x-ray attenuation value ηzPmax,j for each of the projection angles at the maximum profile position Pmax may be calculated using the following equation:

ηzPmax,j=Cmod,j*PAmax,zPmax  (23)

wherein, ηzPmax,j represents the x-ray attenuation value for the jth projection angle at the maximum profile position Pmax,
Cmod,j represents the mean normalized x-ray attenuation value for the jth projection angle at each of Z positions within the overlapping sequence, which may be calculated through the equation (7),
PAmax,zPmax represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at the maximum profile position Pmax.
Similarly, the x-ray attenuation value ηzP min,j for each of the projection angles at the minimum profile position Pmin may be calculated using the following equation:

ηzPmin,j=Cmod,j*PAmax,zPmin  (24)

wherein, ηzP min,j represents the x-ray attenuation value for the jth projection angle at the minimum profile position Pmin,
Cmod,j represents the mean normalized x-ray attenuation value for the jth projection angle at each of Z positions within the overlapping sequence, which may be calculated through the equation (7),
PAmax,zP min represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at the minimum profile position Pmin.
In the above equations (23) and (24), the mean normalized x-ray attenuation Cmod,j for the jth projection angle at each of Z positions within the overlapping sequence which is calculated according to the above equation (7), may be substituted with the mean normalized x-ray attenuation Bmod,j for the jth projection angle at each of Z positions within the overlapping sequence which is calculated according to the above equation (12). Thus, according to another example, the x-ray attenuation value ηzPmax,j for each of the projection angles at the maximum profile position Pmax may be calculated using the following equation:

ηzPmax,j=Bmod,j*DzPmax  (25)

wherein, ηzPmax,j represents the x-ray attenuation value for the jth projection angle at the maximum profile position Pmax,
Bmod,j represents the mean normalized x-ray attenuation value for the jth projection angle at each of Z positions within the overlapping sequence, which may be calculated using the equation (12),
DzP max represents the diameter of the equivalent circular water phantom of the XY scanning profile at the maximum profile position Pmax, that is the maximum equivalent circular water phantom diameter Dmax.
Similarly, the x-ray attenuation value ηzP min,j for each of the projection angles at the minimum profile position Pmin may be calculated using the following equation:

ηzP min,j=Bmod,j*DzP min  (26)

wherein, ηzP min,j represents the x-ray attenuation value for the jth projection angle at the minimum profile position Pmin,
Bmod,j represents the mean normalized x-ray attenuation value for the jth projection angle at each of Z positions within the overlapping sequence, which may be calculated using the equation (12),
DzP min represents the diameter of the equivalent circular water phantom of the XY scanning profile at the minimum profile position Pmin, that is the minimum equivalent circular water phantom diameter Dmin.
Finally, according to the proportional relation between the length of the x-ray attenuation path and the x-ray radiation dose for each of the projection angles, a maximum among x-ray radiation doses for different projection angles j of the equivalent water phantom at a maximum profile position may be determined as a maximum dose threshold value Tmax, and a minimum among x-ray radiation doses for different projection angles j of the equivalent water phantom at a minimum profile position may be determined as a minimum dose threshold value Tmin.
According to an example, an initial x-ray radiation dose may be set according to the maximum equivalent circular water phantom diameter Dmax at the maximum profile position Pmax, the x-ray radiation dose for each of the projection angles j of the equivalent water phantom at the maximum profile position Pmax may be simulated, and then the maximum among the simulated x-ray radiation doses may be determined as the maximum x-ray dose threshold value Tmax.
Similarly, an initial x-ray radiation dose may be set according to the minimum equivalent circular water phantom diameter Dmin at the minimum profile position Pmin, and the x-ray radiation dose for each of the projection angles j of the equivalent water phantom at the minimum profile position Pmin may be simulated, and then a minimum among the simulated x-ray radiation doses may be determined as a minimum dose threshold value Tmin.
Generally, the x-ray attenuation value of the X-ray irradiation may be described as follows:

I=I0·exp(−μl)  (27)

wherein, I0 represents the original x-ray radiation dose of the X-ray irradiation,
I represents the attenuated x-ray radiation dose after the original X-ray irradiation penetrates through the material having an x-ray attenuation coefficient of μ and a length l of the x-ray attenuation path.
It can be seen from the equation (27) that, the length of the x-ray attenuation path is proportional with the modulated x-ray radiation dose. Specifically, as shown in FIG. 6A and FIG. 7A, for a projection angle A having the shortest x-ray attenuation path, its modulated x-ray dose is the smallest, and for a projection angle B having the longest x-ray attenuation path, its modulated x-ray dose is the greatest. Further, the modulated x-ray dose for each of the projection angles are illustrated as modulated dose curves as shown in FIG. 6B and FIG. 7B.
In this way, through the above operation on the equivalent water phantom at the maximum profile position Pmax, the simulated maximum modulated x-ray radiation dose may be derived as the maximum dose threshold value Tmax, and through the above operation on the equivalent water phantom at the minimum profile position Pmin, the simulated minimum modulated x-ray radiation dose may be derived as the minimum dose threshold value Tmin.
Through the method for modulating x-ray radiation dose in CT scan according to the examples of the present disclosure, the x-ray attenuation information of a scan region of a subject is acquired according to a finished axial and/or helical scanning sequence of the subject, and then an optimized x-ray radiation dose modulation may performed based on the acquired x-ray attenuation information, so as to decrease the x-ray radiation dose absorbed by the subject and guarantee the noise consistency between reconstructed CT images for different scan regions of a same subject.
Referring to FIG. 8, in correspondence with the above-described method, the present disclosure provides a device for modulating x-ray radiation dose in CT scan. As shown in FIG. 8, the device includes a processor 81 such as CPU and a machine readable storage medium 82, wherein the processor 81 and the machine readable storage medium 82 are connected with each other through an internal bus 83. In further examples, the device may also include an interface 84 so as to communicate with other devices or components.
In different examples, the machine readable storage medium 82 may include: Random Access Memory (RAM), volatile memory, non-volatile memory, flash memory, memory drive (such as hard disk drive), solid-state hard disk, other types of memory disk (such as optical disc and dvd) or similar types of storage medium or combinations of these.
Further, the machine readable storage medium 82 may be stored with machine-readable instructions of a control logic 90 for modulating x-ray radiation dose in CT scan. In terms of functionality, the control logic may include a x-ray radiation dose modulating module 901.
The x-ray radiation dose modulating module 901 is to acquire the x-ray attenuation information for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence with respect to a scan region of a subject from data of a finished scanning sequence of the subject, and modulate the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence according to the acquired x-ray attenuation information. Wherein, Z position represents a position in Z direction, Z direction represents a direction extending from head to foot of the subject or conversely, and the XY scanning profile represents a profile of the subject which is vertical to Z direction.
According to an example, if the planned scanning sequence is within the finished scanning sequence, the x-ray radiation dose modulating module 901 may specifically calculate the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence according to the following equation:




  
    
      I
      
        mod
        ,
        zi
        ,
        j
      
    
    =
    
      
        
          M
          ·
          
            I
            
              mod
              ,
              zi
              ,
              start
            
          
        
        
          
            ∑
            
              j
              =
              1
            
            M
          
          ⁢
          
            
              A
              
                max
                ,
                zi
                ,
                j
              
            
          
        
      
      ·
      
        
          A
          
            max
            ,
            zi
            ,
            j
          
        
      
    
  
  ;




wherein, Imod,zi,j represents the x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents the initial x-ray radiation dose at Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi and may be acquired from data of the finished scanning sequence.
According to another example, if the planned scanning sequence goes beyond the finished scanning sequence and the pilot image data of the planned scanning sequence has no abrupt change in Z direction, then the control logic 90 may further include a shape ratio determining module, which is to acquire shape ratio information of the XY scanning profile at each of Z positions within an overlapping sequence, and according to the acquired shape ratio information, determine whether the XY scanning profiles at different Z positions are similar. Wherein, the overlapping sequence represents a part of the planned scanning sequence which is overlapped with the finished scanning sequence.
In the above case, the x-ray radiation dose modulating module 901 may be further to: if it is determined that the XY scanning profiles at different Z positions are similar, calculate the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence according to the following equation:




  
    I
    
      mod
      ,
      zi
      ⁢
      
        
      
      ,
      j
    
  
  =
  
    {
    
      
        
          
            
              
                T
                max
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≥
              
                T
                max
              
            
          
        
        
          
            
              
                
                  mod
                  ⁢
                  
                    
                  
                  ⁢
                  v
                
                =
                
                  
                    
                      M
                      ·
                      
                        I
                        
                          mod
                          ,
                          zi
                          ,
                          start
                        
                      
                    
                    
                      
                        ∑
                        
                          j
                          =
                          1
                        
                        M
                      
                      ⁢
                      
                        
                          A
                          
                            max
                            ,
                            zi
                            ,
                            j
                          
                        
                      
                    
                  
                  ·
                  
                    
                      A
                      
                        max
                        ,
                        zi
                        ,
                        j
                      
                    
                  
                
              
              ,
            
          
          
            
              
                T
                min
              
              ≤
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                max
              
            
          
        
        
          
            
              
                T
                min
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                min
              
            
          
        
      
      ;
    
  




wherein, Imod,zi,j represents the x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents the initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi, and if Z position zi is within the overlapping sequence, it may be directly acquired from data of the finished scanning sequence, otherwise, it may be calculated based on a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at another Z position which is closest to the Z position zi,
Tmax and Tmin represent a maximum x-ray dose threshold value and a minimum x-ray dose threshold value respectively.
According to an example, the shape ratio determining module may specifically include:
a shape ratio information calculating sub-module, which is to calculate the ratio between the long axis and the short axis of the equivalent elliptical water phantom of the XY scanning profile at each of Z positions within the overlapping sequence as the shape ratio information, or calculate the x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence as the shape ratio information;
a variance calculating sub-module, which is to: calculate an arithmetic mean for the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence, as a mean shape ratio information of the overlapping sequence; and calculate a variance with the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence and the mean shape ratio information of the overlapping sequence, as a variance regarding shape ratio information of the overlapping sequence;
a determining sub-module, which is to determine whether the variance regarding shape ratio information is larger than a preset threshold or not, and if yes, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are not similar, and if not, it may indicate that the XY scanning profiles at different Z positions within the overlapping sequence are similar.
In the case of calculating the x-ray attenuation deviation as the shape ratio information, the x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence may be calculated according to the following equation:




  
    
      Δ
      ⁢
      
        
      
      ⁢
      
        C
        
          mod
          ,
          zi
        
      
    
    =
    
      
        
          ∑
          
            j
            =
            1
          
          M
        
        ⁢
        
          
          
            
              C
              
                mod
                ,
                zi
                ,
                j
              
            
            -
            
              
                
                  ∑
                  
                    i
                    =
                    1
                  
                  NumZ
                
                ⁢
                
                  C
                  
                    mod
                    ,
                    zi
                    ,
                    j
                  
                
              
              NumZ
            
          
          
        
      
      M
    
  
  ,




wherein, ΔCmod,zi represents the x-ray attenuation deviation of each of Z positions zi within the overlapping sequence with respect to the whole overlapping sequence,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle,
NumZ represents a quantity of Z positions within the overlapping sequence, and i represents an index number of the ith Z position,
Cmod,zi,j represents the normalized x-ray attenuation value for each of the projection angles at each of Z positions zi, which may be calculated by normalizing a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi with a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zi or the diameter of the equivalent circular water phantom of the XY scanning profile at Z positions zi.
According to an example, in terms of functionality, the control logic 90 may further include:
a water phantom diameter determining module, which is to determine the diameter of the equivalent circular water phantom at each of Z positions within the planned scanning sequence based on pre-acquired pilot image data of the subject;
a profile position determining module, which is to select a maximum diameter and a minimum diameter of the diameters determined by the water phantom diameter determining module as the maximum equivalent circular water phantom diameter and the minimum equivalent circular water phantom diameter respectively, and determine Z position of a maximum equivalent circular water phantom diameter as a first profile position, and Z position of a minimum equivalent circular water phantom diameter as a second profile position;
a x-ray dose threshold value determining module, which is to convert the equivalent circular water phantom at the first profile position into a first equivalent water phantom of the same area, and convert the equivalent circular water phantom at the second profile position into a second equivalent water phantom of the same area, and according to the proportional relation of the length of the x-ray attenuation path and the x-ray radiation dose for each of the projection angles, determine a maximum x-ray radiation dose among the projection angles of the first equivalent water phantom as a maximum x-ray dose threshold value Tmax, and determine a minimum x-ray radiation dose among the projection angles of the second equivalent water phantom as a minimum x-ray dose threshold value Tmin.
According to an example, in the pilot image data of the subject, a set of slice data corresponding to a Z position within the planned scanning sequence may be {μ1l1, μ2l2, . . . μili}, i=1, 2, 3, . . . , N, and the water phantom diameter determining module may calculate the diameter of the equivalent circular water phantom at Z position through the following equation:




  
    
      D
      water
    
    =
    
      
        2
        
          μ
          water
        
      
      ·
      
        
          S
          π
        
      
    
  
  ,
  
    

  
  ⁢
  
    S
    =
    
      
        ∑
        
          i
          =
          1
        
        N
      
      ⁢
      
        
          
            (
            
              
                
                  μ
                  i
                
                ⁢
                
                  l
                  i
                
              
              +
              
                
                  μ
                  
                    i
                    +
                    1
                  
                
                ⁢
                
                  l
                  
                    i
                    +
                    1
                  
                
              
            
            )
          
          ·
          Δ
        
        ⁢
        
          /
        
        ⁢
        2
      
    
  
  ,
  
    

  
  ⁢
  
    Δ
    =
    
      R
      ·
      
        θ
        N
      
      ·
      
        g
        ⁡
        
          (
          
            
              h
              bed
            
            ,
            
              h
              center
            
          
          )
        
      
    
  
  ,




wherein, μwater represents the x-ray attenuation coefficient of water,
S represents the x-ray attenuation area of the equivalent circular water phantom of the set of slice data {μ1l1, μ2l2, . . . μili}, i=1, 2, 3, . . . , N,
μi represents the mean x-ray attenuation coefficient on the ith detection channel,
li, represents the length of the x-ray attenuation path on the ith detection channel,
N represents a quantity of detection channels,
Δ represents the distance between the centres of the adjacent detection units,
R represents the radius of rotation, and θ represents the sector angle formed between the detection units and the bulb tube,
hbed represents the distance between the scanning bed and the floor,
hcenter represents the distance between the centre of rotation and the floor, and g(hbed,hcenter) represents a function modifying Δ, and when the subject is located at the centre of rotation, g(hbed,hcenter)<1; when the subject is located above the centre of rotation, g(hbed,hcenter)<1; and when the subject is located below the centre of rotation, g(hbed,hcenter)>1, and its specific value may be acquired by querying a table.
A process in which the device runs the control logic 90 for modulating x-ray radiation dose in CT scan will be described further below with respect to software implementation as an example. In this example, the disclosed control logic 90 should be understood as computer executable instructions stored in the machine readable storage medium 82. When the processor 81 on the disclosed device executes the control logic 90, the processor 81 carries out the following operations by invoking instructions of corresponding functional modules of control logic 90 stored on the machine readable storage medium 82:
acquiring x-ray attenuation information for each of the projection angles of the XY scanning profile at each of Z positions within a planned scanning sequence of a subject from data of a finished scanning sequence of the subject; and
modulating, according to the acquired x-ray attenuation information, the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence,
wherein, Z position represents a position in Z direction, Z direction represents a direction extending from head to foot of the subject or conversely, and the XY scanning profile represents a profile of the subject which is vertical to Z direction.
According to an example, if the planned scanning sequence is within the finished scanning sequence, the instructions further cause the processor to perform the following operations:
acquiring a maximum x-ray attenuation value for each of the projection angles at each of Z positions within the planned scanning sequence from the data of the finished scanning sequence, and
calculating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence with the following equation:




  
    
      I
      
        mod
        ,
        zi
        ,
        j
      
    
    =
    
      
        
          M
          ·
          
            I
            
              mod
              ,
              zi
              ,
              start
            
          
        
        
          
            ∑
            
              j
              =
              1
            
            M
          
          ⁢
          
            
              A
              
                max
                ,
                zi
                ,
                j
              
            
          
        
      
      ·
      
        
          A
          
            max
            ,
            zi
            ,
            j
          
        
      
    
  
  ;




wherein, Imod,zi,j represents the x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents the initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle, and
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi and is acquired from the data of the finished scanning sequence.
According to an example, if the planned scanning sequence goes beyond the finished scanning sequence and the pilot image data of the planned scanning sequence has no abrupt change in Z direction, the instructions further cause the processor to perform the following operations:
acquiring shape ratio information of the XY scanning profile at each of Z positions in an overlapping sequence, wherein the overlapping sequence is a part of the planned scanning sequence which is overlapped with the finished scanning sequence, and
determining whether the XY scanning profiles at different Z positions within the overlapping sequence are similar or not based on the acquired shape ratio information, and
modulating, if the determination result is yes, the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence according to the acquired x-ray attenuation information.
Further, the instructions cause the processor to perform the following operations:
acquiring a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions within the overlapping sequence from the data of the finished scanning sequence; and
calculating a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions zout within the planned scanning sequence but not in the overlapping sequence according to the following equation:




  
    A
    
      max
      ,
      zout
      ,
      j
    
  
  =
  
    
      A
      
        max
        ,
        
          zout
          -
          1
        
        ,
        j
      
    
    ⁢
    
      
        PA
        
          max
          ,
          zout
        
      
      
        PA
        
          max
          ,
          
            zout
            -
            1
          
        
      
    
  




wherein, Amax,zout,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout;
Amax,zout-1,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout−1 which is closest to the Z position zout;
PAmax,zout represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout and is determined from a pre-acquired pilot image data of the subject;
PAmax,zout-1 represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout−1 and is determined from a pre-acquired pilot image data of the subject.
Further, the instructions cause the processor to perform the following operations:
calculating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence through the following equation:




  
    I
    
      mod
      ,
      zi
      ⁢
      
        
      
      ,
      j
    
  
  =
  
    {
    
      
        
          
            
              
                T
                max
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≥
              
                T
                max
              
            
          
        
        
          
            
              
                
                  mod
                  ⁢
                  
                    
                  
                  ⁢
                  v
                
                =
                
                  
                    
                      M
                      ·
                      
                        I
                        
                          mod
                          ,
                          zi
                          ,
                          start
                        
                      
                    
                    
                      
                        ∑
                        
                          j
                          =
                          1
                        
                        M
                      
                      ⁢
                      
                        
                          A
                          
                            max
                            ,
                            zi
                            ,
                            j
                          
                        
                      
                    
                  
                  ·
                  
                    
                      A
                      
                        max
                        ,
                        zi
                        ,
                        j
                      
                    
                  
                
              
              ,
            
          
          
            
              
                T
                min
              
              ≤
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                max
              
            
          
        
        
          
            
              
                T
                min
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                min
              
            
          
        
      
      ;
    
  




wherein, Imod,zi,j represents the x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents the initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi,
Tmax and Tmin represent a maximum x-ray dose threshold value and a minimum x-ray dose threshold value respectively,
mod ν represents an intermediate x-ray value for comparing with Tmax and Tmin to determine Imod,zi,j.
According to examples of the disclosure, the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence may be one of the following:
the ratio between the long axis and the short axis for the equivalent elliptical water phantom of the XY scanning profile at each of Z positions within the overlapping sequence, or
the x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence.
Further, according to an example, the x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence is calculated through the following equation:




  
    
      Δ
      ⁢
      
        
      
      ⁢
      
        C
        
          mod
          ,
          zi
        
      
    
    =
    
      
        
          ∑
          
            j
            =
            1
          
          M
        
        ⁢
        
          
          
            
              C
              
                mod
                ,
                zi
                ,
                j
              
            
            -
            
              
                
                  ∑
                  
                    i
                    =
                    1
                  
                  NumZ
                
                ⁢
                
                  C
                  
                    mod
                    ,
                    zi
                    ,
                    j
                  
                
              
              NumZ
            
          
          
        
      
      M
    
  
  ,




wherein, ΔCmod,zi represents the x-ray attenuation deviation of each of Z positions zi within the overlapping sequence with respect to the whole overlapping sequence,
M represents a quantity of projection angles, j represents an index number of the jth projection angle,
NumZ represents a quantity of Z positions within the overlapping sequence, i represents an index number of the ith Z position,
Cmod,zi,j represents the normalized x-ray attenuation value for each of the projection angles at each of Z positions zi, which is calculated by normalizing a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi with a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zi or the diameter of the equivalent circular water phantom of the XY scanning profile at Z position zi.
Further, the instructions cause the processor to perform the following operations:
calculating an arithmetic mean for the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence, as a mean shape ratio information of the overlapping sequence;
calculating a variance with the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence and the mean shape ratio information of the overlapping sequence, as a variance regarding shape ratio information of the overlapping sequence; and
determining whether the variance regarding shape ratio information is larger than a preset threshold value or not, and if yes, it indicates that the XY scanning profiles at different Z positions within the overlapping sequence are not similar, and if no, it indicates that the XY scanning profiles at different Z positions within the overlapping sequence are similar.
Further, the instructions cause the processor to perform the following operations:
calculating the diameter of equivalent circular water phantom at each of Z positions within the planned scanning sequence based on a pre-acquired pilot image data of the subject;
determining a maximum and a minimum among the calculated diameters as a maximum equivalent circular water phantom diameter and a minimum equivalent circular water phantom diameter respectively,
determining the Z position of a maximum equivalent circular water phantom diameter as a first profile position and the Z position of a minimum equivalent circular water phantom diameter as a second profile position;
converting the equivalent circular water phantom at the first profile position into a first equivalent water phantom of the same area, and converting the equivalent circular water phantom at the second profile position into a second equivalent water phantom of the same area; and
according to the proportional relation between the length of the x-ray attenuation path and the x-ray radiation dose for each of the projection angles, determining a maximum of the x-ray radiation doses for projection angles of the first equivalent water phantom as a maximum x-ray dose threshold value Tmax, and determining a minimum of the x-ray radiation doses for projection angles of the second equivalent water phantom as a minimum x-ray dose threshold value Tmin.
The above are only preferred examples of the present disclosure is not intended to limit the disclosure within the spirit and principles of the present disclosure, any changes made, equivalent replacement, or improvement in the protection of the present disclosure should contain within the range.
The methods, processes and units described herein may be implemented by hardware (including hardware logic circuitry), software or firmware or a combination thereof. The term ‘processor’ is to be interpreted broadly to include a processing unit, ASIC, logic unit, or programmable gate array etc. The processes, methods and functional units may all be performed by the one or more processors; reference in this disclosure or the claims to a ‘processor’ should thus be interpreted to mean ‘one or more processors’.
Further, the processes, methods and functional units described in this disclosure may be implemented in the form of a computer software product. The computer software product is stored in a storage medium and comprises a plurality of instructions for making a processor to implement the methods recited in the examples of the present disclosure.
The figures are only illustrations of an example, wherein the units or procedure shown in the figures are not necessarily essential for implementing the present disclosure. Those skilled in the art will understand that the units in the device in the example can be arranged in the device in the examples as described, or can be alternatively located in one or more devices different from that in the examples. The units in the examples described can be combined into one module or further divided into a plurality of sub-units.
Although the flowcharts described show a specific order of execution, the order of execution may differ from that which is depicted. For example, the order of execution of two or more blocks may be changed relative to the order shown. Also, two or more blocks shown in succession may be executed concurrently or with partial concurrence. All such variations are within the scope of the present disclosure.
Throughout the present disclosure, the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.
It will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the above-described embodiments, without departing from the broad general scope of the present disclosure. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive.

## Claims

1. A method for modulating x-ray radiation dose in CT scan, the method comprising:
acquiring, from data of a finished scanning sequence of a subject, x-ray attenuation information for each of the projection angles of the XY scanning profile at each of Z positions within a planned scanning sequence of the subject; and
modulating, according to the acquired x-ray attenuation information, an x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence;
wherein Z position includes a position in Z direction from head to foot of the subject or conversely, the XY scanning profile represents a profile of the subject which is vertical to Z direction and the finished scanning sequence of the subject includes a scanning sequence for a same scan region of the same subject which has been finished before current time;
wherein when the planned scanning sequence goes beyond the finished scanning sequence and pilot image data of the planned scanning sequence has no abrupt change in Z direction, the method further includes:
acquiring shape ratio information of the XY scanning profile at each of Z positions in an overlapping sequence, wherein the overlapping sequence is a part of the planned scanning sequence which is overlapped with the finished scanning sequence, and
determining whether the XY scanning profiles at different Z positions within the overlapping sequence are similar to each other based on the acquired shape ratio information,
when the XY scanning profiles at different Z positions within the overlapping sequence are determined as being similar to each other, modulating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence according to the acquired x-ray attenuation information.

2. The method of claim 1, wherein, when the planned scanning sequence is within the finished scanning sequence:
said acquiring the x-ray attenuation information for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence includes: acquiring, from the data of the finished scanning sequence, a maximum x-ray attenuation value for each of the projection angles at each of Z positions within the planned scanning sequence, and
said modulating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence includes: calculating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence with the following equation:





  
    
      I
      
        mod
        ,
        zi
        ,
        j
      
    
    =
    
      
        
          M
          ·
          
            I
            
              mod
              ,
              zi
              ,
              start
            
          
        
        
          
            ∑
            
              j
              =
              1
            
            M
          
          ⁢
          
            
              A
              
                max
                ,
                zi
                ,
                j
              
            
          
        
      
      ·
      
        
          A
          
            max
            ,
            zi
            ,
            j
          
        
      
    
  
  ;



wherein, Imod,zi,j represents an x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents an initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jthprojection angle, and
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi and is acquired from the data of the finished scanning sequence.

3. The method of claim 1, said acquiring the x-ray attenuation information for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence, includes:
acquiring a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions within the overlapping sequence from the data of the finished scanning sequence; and
calculating a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions zout within the planned scanning sequence but not in the overlapping sequence according to the following equation:





  
    A
    
      max
      ,
      zout
      ,
      j
    
  
  =
  
    
      A
      
        max
        ,
        
          zout
          -
          1
        
        ,
        j
      
    
    ⁢
    
      
        PA
        
          max
          ,
          zout
        
      
      
        PA
        
          max
          ,
          
            zout
            -
            1
          
        
      
    
  



wherein, Amax,zout,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout;
Amax,zout−1,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout−1 which is closest to the Z position zout;
PAmax,zout represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout and is determined from a pre-acquired pilot image data of the subject; and
PAmax,zout−1 represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout−1 and is determined from pre-acquired pilot image data of the subject.

4. The method of claim 3, wherein, said modulating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence, includes:
calculating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence through the following equation:





  
    I
    
      mod
      ,
      zi
      ⁢
      
        
      
      ,
      j
    
  
  =
  
    {
    
      
        
          
            
              
                T
                max
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≥
              
                T
                max
              
            
          
        
        
          
            
              
                
                  mod
                  ⁢
                  
                    
                  
                  ⁢
                  v
                
                =
                
                  
                    
                      M
                      ·
                      
                        I
                        
                          mod
                          ,
                          zi
                          ,
                          start
                        
                      
                    
                    
                      
                        ∑
                        
                          j
                          =
                          1
                        
                        M
                      
                      ⁢
                      
                        
                          A
                          
                            max
                            ,
                            zi
                            ,
                            j
                          
                        
                      
                    
                  
                  ·
                  
                    
                      A
                      
                        max
                        ,
                        zi
                        ,
                        j
                      
                    
                  
                
              
              ,
            
          
          
            
              
                T
                min
              
              ≤
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                max
              
            
          
        
        
          
            
              
                T
                min
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                min
              
            
          
        
      
      ;
    
  



wherein, Imod,zi, j represents an x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents an initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi,
Tmax and Tmin represent a maximum x-ray dose threshold value and a minimum x-ray dose threshold value respectively, and
mod v represents an intermediate x-ray value for comparing with Tmax and Tmin to determine Imod,zi,j.

5. The method of claim 1, wherein, the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence is one of the following:
the ratio between a long axis and a short axis for the equivalent elliptical water phantom of the XY scanning profile at each of Z positions within the overlapping sequence, or
an x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence.

6. The method of claim 5, wherein, the x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence is calculated through the following equation:




  
    
      Δ
      ⁢
      
        
      
      ⁢
      
        C
        
          mod
          ,
          zi
        
      
    
    =
    
      
        
          ∑
          
            j
            =
            1
          
          M
        
        ⁢
        
          
          
            
              C
              
                mod
                ,
                zi
                ,
                j
              
            
            -
            
              
                
                  ∑
                  
                    i
                    =
                    1
                  
                  NumZ
                
                ⁢
                
                  C
                  
                    mod
                    ,
                    zi
                    ,
                    j
                  
                
              
              NumZ
            
          
          
        
      
      M
    
  
  ,



wherein, ΔCmod,zi represents an x-ray attenuation deviation of each of Z positions zi within the overlapping sequence with respect to the whole overlapping sequence,
M represents a quantity of projection angles, j represents an index number of the jth projection angle,
NumZ represents a quantity of Z positions within the overlapping sequence, i represents an index number of the ith Z position,
Cmod,zi,j represents a normalized x-ray attenuation value for each of the projection angles at each of Z positions zi, which is calculated by normalizing the maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi with a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zi or the diameter of the equivalent circular water phantom of the XY scanning profile at Z position zi.

7. The method of claim 1, wherein, said determining whether the XY scanning profiles at different Z positions within the overlapping sequence are similar to each other based on the acquired shape ratio information, includes:
calculate an arithmetic mean for the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence, as a mean shape ratio information of the overlapping sequence;
calculating a variance with the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence and the mean shape ratio information of the overlapping sequence, as a variance regarding shape ratio information of the overlapping sequence; and
determining whether the variance regarding shape ratio information is larger than a preset threshold value or not, wherein if the variance is determined as being larger than the preset threshold value, it is indicated that the XY scanning profiles at different Z positions within the overlapping sequence are not similar, and if the variance is determined as being not larger than the preset threshold value, it is indicated that the XY scanning profiles at different Z positions within the overlapping sequence are similar.

8. The method of claim 4, further including:
calculating the diameter of equivalent circular water phantom at each of Z positions within the planned scanning sequence based on pre-acquired pilot data of the subject;
determining a maximum diameter and a minimum diameter among the calculated diameters as a maximum equivalent circular water phantom diameter and a minimum equivalent circular water phantom diameter respectively,
determining the Z position of the maximum equivalent circular water phantom diameter as a first profile position and the Z position of the minimum equivalent circular water phantom diameter as a second profile position;
converting the equivalent circular water phantom at the first profile position into a first equivalent water phantom of the same area, and converting the equivalent circular water phantom at the second profile position into a second equivalent water phantom of the same area; and
according to the proportional relation between the length of the x-ray attenuation path and the x-ray radiation dose for each of the projection angles, determining the maximum of the x-ray radiation doses for projection angles of the first equivalent water phantom as the maximum x-ray dose threshold value Tmax, and determining the minimum of the x-ray radiation doses for projection angles of the second equivalent water phantom as the minimum x-ray dose threshold value Tmin.

9. A device for modulating x-ray radiation dose in CT scan, the device comprising:
a processor configured to execute machine readable instructions corresponding to a control logic for modulating x-ray radiation dose in CT scan, the machine readable instructions being stored on a storage medium and, when executed, causing the processor to:
acquire, from data of a finished scanning sequence of a subject, x-ray attenuation information for each of the projection angles of the XY scanning profile at each of Z positions within a planned scanning sequence of the subject; and
modulate, according to the acquired x-ray attenuation information, an x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence;
wherein Z position represents a position in Z direction from head to foot of the subject or conversely, the XY scanning profile represents a profile of the subject which is vertical to Z direction and the finished scanning sequence of the subject includes a scanning sequence for a same scan region of the same subject which has been finished before current time;
wherein when the planned scanning sequence goes beyond the finished scanning sequence and pilot image data of the planned scanning sequence has no abrupt change in Z direction, the instructions further cause the processor to:
acquire shape ratio information of the XY scanning profile at each of Z positions in an overlapping sequence, wherein the overlapping sequence is a part of the planned scanning sequence which is overlapped with the finished scanning sequence, and
determine whether the XY scanning profiles at different Z positions within the overlapping sequence are similar to each other based on the acquired shape ratio information,
when the XY scanning profiles at different Z positions within the overlapping sequence are determined as being similar to each other, modulate the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence according to the acquired x-ray attenuation information.

10. A device for modulating x-ray radiation dose in CT scan, the device comprising:
a processor configured to execute machine readable instructions corresponding to a control logic for modulating x-ray radiation dose in CT scan, the machine readable instructions being stored on a storage medium and, when executed, causing the processor to perform the method for modulating x-ray radiation dose in CT scan, wherein said modulating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions within the planned scanning sequence includes:
calculating the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence with the following equation:





  
    
      I
      
        mod
        ,
        zi
        ,
        j
      
    
    =
    
      
        
          M
          ·
          
            I
            
              mod
              ,
              zi
              ,
              start
            
          
        
        
          
            ∑
            
              j
              =
              1
            
            M
          
          ⁢
          
            
              A
              
                max
                ,
                zi
                ,
                j
              
            
          
        
      
      ·
      
        
          A
          
            max
            ,
            zi
            ,
            j
          
        
      
    
  
  ;



wherein, Imod,zi,j represents an x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents an initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle, and
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi and is acquired from the data of the finished scanning sequence.

11. The device of claim 9, the instructions further cause the processor to:
acquire a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions within the overlapping sequence from the data of the finished scanning sequence; and
calculate a maximum x-ray attenuation value for each of the projection angles of the XY scanning profile at each of Z positions zout within the planned scanning sequence but not in the overlapping sequence according to the following equation:





  
    A
    
      max
      ,
      zout
      ,
      j
    
  
  =
  
    
      A
      
        max
        ,
        
          zout
          -
          1
        
        ,
        j
      
    
    ⁢
    
      
        PA
        
          max
          ,
          zout
        
      
      
        PA
        
          max
          ,
          
            zout
            -
            1
          
        
      
    
  



wherein, Amax,zout,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout;
Amax,zout−1,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zout−1 which is closest to the Z position zout;
PAmax,zout represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout and is determined from a pre-acquired pilot image data of the subject;
PAmax,zout−1 represents a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zout−1 and is determined from pre-acquired pilot image data of the subject.

12. The device of claim 11, wherein, the instructions further cause the processor to:
calculate the x-ray radiation dose for each of the projection angles of the XY scanning profile at each of Z positions zi within the planned scanning sequence through the following equation:





  
    I
    
      mod
      ,
      zi
      ⁢
      
        
      
      ,
      j
    
  
  =
  
    {
    
      
        
          
            
              
                T
                max
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≥
              
                T
                max
              
            
          
        
        
          
            
              
                
                  mod
                  ⁢
                  
                    
                  
                  ⁢
                  v
                
                =
                
                  
                    
                      M
                      ·
                      
                        I
                        
                          mod
                          ,
                          zi
                          ,
                          start
                        
                      
                    
                    
                      
                        ∑
                        
                          j
                          =
                          1
                        
                        M
                      
                      ⁢
                      
                        
                          A
                          
                            max
                            ,
                            zi
                            ,
                            j
                          
                        
                      
                    
                  
                  ·
                  
                    
                      A
                      
                        max
                        ,
                        zi
                        ,
                        j
                      
                    
                  
                
              
              ,
            
          
          
            
              
                T
                min
              
              ≤
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                max
              
            
          
        
        
          
            
              
                T
                min
              
              ,
            
          
          
            
              
                mod
                ⁢
                
                  
                
                ⁢
                v
              
              ≤
              
                T
                min
              
            
          
        
      
      ;
    
  



wherein, Imod,zi,j represents an x-ray radiation dose for the jth projection angle of the XY scanning profile at Z position zi,
Imod,zi,start represents an initial x-ray radiation dose of Z position zi,
M represents a quantity of projection angles, and j represents an index number of the jth projection angle,
Amax,zi,j represents a maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi, Tmaxand Tmin represent a maximum x-ray dose threshold value and a minimum x-ray dose threshold value respectively,
mod v represents an intermediate x-ray value for comparing with Tmax and Tmin to determine Imod,zi,j.

13. The device of claim 9, wherein, the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence is one of the following:
the ratio between a long axis and a short axis for the equivalent elliptical water phantom of the XY scanning profile at each of Z positions within the overlapping sequence, or
an x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence.

14. The device of claim 13, wherein, the instructions further cause the processor to:
calculate the x-ray attenuation deviation of each of Z positions within the overlapping sequence with respect to the whole overlapping sequence through the following equation:





  
    
      Δ
      ⁢
      
        
      
      ⁢
      
        C
        
          mod
          ,
          zi
        
      
    
    =
    
      
        
          ∑
          
            j
            =
            1
          
          M
        
        ⁢
        
          
          
            
              C
              
                mod
                ,
                zi
                ,
                j
              
            
            -
            
              
                
                  ∑
                  
                    i
                    =
                    1
                  
                  NumZ
                
                ⁢
                
                  C
                  
                    mod
                    ,
                    zi
                    ,
                    j
                  
                
              
              NumZ
            
          
          
        
      
      M
    
  
  ,



wherein, ΔCmod,zi, represents an x-ray attenuation deviation of each of Z positions zi within the overlapping sequence with respect to the whole overlapping sequence,
M represents a quantity of projection angles, j represents an index number of the jth projection angle,
NumZ represents a quantity of Z positions within the overlapping sequence, i represents an index number of the ith Z position,
Cmod,zi,j represents the normalized x-ray attenuation value for each of the projection angles at each of Z positions zi , which is calculated by normalizing the maximum x-ray attenuation value for the jth projection angle of the XY scanning profile at Z position zi with a maximum x-ray attenuation value in pilot image scanning of the XY scanning profile at Z position zi or the diameter of the equivalent circular water phantom of the XY scanning profile at Z position zi.

15. The device of claim 9, wherein, the instructions further cause the processor to:
calculate an arithmetic mean for the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence, as a mean shape ratio information of the overlapping sequence;
calculate a variance with the shape ratio information of the XY scanning profile at each of Z positions within the overlapping sequence and the mean shape ratio information of the overlapping sequence, as a variance regarding shape ratio information of the overlapping sequence; and
determine whether the variance regarding shape ratio information is larger than a preset threshold value or not, wherein if the variance is determined as being larger than the preset threshold value, it is indicated that the XY scanning profiles at different Z positions within the overlapping sequence are not similar, and if the variance is determined as being not larger than the preset threshold value, it is indicated that the XY scanning profiles at different Z positions within the overlapping sequence are similar.

16. The device of claim 12, wherein, the instruction further cause the processor to:
calculate the diameter of equivalent circular water phantom at each of Z positions within the planned scanning sequence based on a pre-acquired pilot image data of the subject;
determine a maximum diameter and a minimum diameter among the calculated diameters as a maximum equivalent circular water phantom diameter and a minimum equivalent circular water phantom diameter respectively,
determine the Z position of the maximum equivalent circular water phantom diameter as a first profile position and the Z position of the minimum equivalent circular water phantom diameter as a second profile position;
convert the equivalent circular water phantom at the first profile position into a first equivalent water phantom of the same area, and convert the equivalent circular water phantom at the second profile position into a second equivalent water phantom of the same area; and
according to the proportional relation between the length of the x-ray attenuation path and the x-ray radiation dose for each of the projection angles, determine the maximum of the x-ray radiation doses for projection angles of the first equivalent water phantom as the maximum x-ray dose threshold value Tmax, and determine the minimum of the x-ray radiation doses for projection angles of the second equivalent water phantom as the minimum x-ray dose threshold value Tmin.