22110 Federal Register / Vol. 76, No. 76 / Wednesday, April 20, 2011 / Notices 

targeting could have therapeutic 

potential. Inactivation of TSLP 

expression or its receptor signaling can 

effectively control cancer progression 

and metastasis (1). 

Applications: 

• In treatments to control cancer 

invasion and spreading 

• Cancer treatment that circumvents 

cancer-induced immune suppression 

• As a means to augment anti-tumor 

immune responses 

• For the development of prognostic 

markers for disease outcome in cancer 

patients 

Inventors: Arya Biragyn (NIA), Warren 

J. Leonard (NHLBI) 

Relevant Publications: 

1. Olkhanud PB, Rochman Y, Bodogai 

M, Malchinkhuu E, Wejksza K, Xu M, 

Gress RE, Hesdorffer C, Leonard WJ, 

Biragyn A. Thymic stromal 

lymphopoietin is a key mediator of 

breast cancer progression. J Immunol. 

2011;V:186, In Press. 

2. De Monte L, Reni M, Tassi E, 

Clavenna D, Papa I, Recalde H, Braga M, 

Di Carlo V, Doglioni C, Protti MP. 

Intratumor T helper type 2 cell infiltrate 

correlates with cancer-associated 

fibroblast thymic stromal lymphopoietin 

production and reduced survival in 

pancreatic cancer. J Exp Med. 2011 Mar 

14;208(3):469–478. [PubMed: 21339327] 

3. Pedroza-Gonzalez A, Xu K, Wu TC, 

Aspord C, Tindle S, Marches F, Gallegos 

M, Burton EC, Savino D, Hori T, Tanaka 

Y, Zurawski S, Zurawski G, Bover L, Liu 

YJ, Banchereau J, Palucka AK. Thymic 

stromal lymphopoietin fosters human 

breast tumor growth by promoting type 

2 inflammation. J Exp Med. 2011 Mar 

14;208(3):479–490. [PubMed: 21339324] 

Patent Status: U.S. Provisional 

Application No. 61/416,619 filed 

November 23, 2010 (HHS Reference No. 

E–019–2011/0–US–01) 

Licensing Status: Available for 

licensing. 

Licensing Contact: Patrick P. McCue, 

PhD; 301–435–5560; 

mccuepat@mail.nih.gov 

Collaborative Research Opportunity: 

The National Institute on Aging, 

Immunotherapeutics Unit, is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate, or 

commercialize clinical application of 

TSLP in cancers. Please contact Nicole 

Guyton, PhD at 301–435–3101 or 

darackn@mail.nih.gov for more 

information. 

System and Method for Producing 

Nondiffracting Light Sheets That 

Improves the Performance of Selective 

Plane Illumination Microscopy (SPIM) 

Description of Technology: The 

technology offered for licensing relates 

to a system and method of producing 

nondiffracting beams of light that 

spatially overlap, but do not interfere 

with each other when intersecting the 

detection plane of an optical 

arrangement. The system includes an 

illumination source (i.e., ultrafast laser) 

for transmitting a beam of light through 

the optical arrangement that includes a 

diffraction grating for diffracting the 

light beam to produce beams of light 

having different wavelengths, which are 

then passed through an annular aperture 

that transforms the beams of light into 

nondiffracting beams having different 

wavelengths. The method can be readily 

utilized in Selective Plane Illumination 

Microscopy (SPIM), a system that 

provides optical sectioning of a sample 

that is labeled with fluorescent dyes. 

SPIM can provide quantitative threedimensional maps of the distribution of 

a flurophore within the sample with 

high spatiotemporal resolution and an 

excellent signal-to-noise ratio. The 

standard SPIM technique however 

produces nonuniform axial resolution, 

which is caused by the diffraction of the 

laser beam through the sample, causing 

degradation in the optical sectioning, 

and forcing a compromise between field 

of view and axial resolution. 

Techniques for decoupling field of view 

and axial resolution have previously 

utilized nondiffracting beams (e.g., 

Bessel beams) for sample illumination. 

The resulting interference from multiple 

nondiffracting beams degrades the 

quality of optical sectioning and the 

quality of the image. The present 

technology utilizing nondiffracting 

noninterfering beams is intended to 

alleviate the problems associated with 

the currently used SPIM techniques. 

Applications: In Selective Plane 

Illumination Microscopy (SPIM) used 

for optical sectioning and imaging of 

biological samples. 

Development Status: Proof of concept 

has been demonstrated. 

Inventors: Andrew York, Yicong Wu, 

Hari Shroff (NIBIB) 

Relevant Publications: 

1. Durnin J, Micheli J Jr, Eberly JH. 

Diffraction-free beams. Phys Rev Lett. 

1987 Apr 13;58(15):1499–1501. 

2. Greger K, Swoger J, Stelzer EH. Basic 

building units and properties of a 

fluorescence single plane illumination 

microscope. Rev Sci Instrum. 2007 

Feb;78(2):023705. [PubMed: 17578115] 

3. Fahrbach F, Rohrbach A. Microscopy with 

Non-diffracting Beams. Abstract at 2009 

Focus on Microscopy Conference, http:// 

www.focusonmicroscopy.org/2009/PDF/

28l_Fahrbach.pdf. 

4. Rohrbach A. Artifacts resulting from 

imaging in scattering media: a theoretical 

prediction. Opt Lett. 2009 Oct 

1;34(19):3041–3043. [PubMed: 

19794809] 

Patent Status: U.S. Provisional 

Application No. 61/360,352 filed 30 Jun 

2010, entitled ‘‘System and Method of 

Producing Nondiffracting Light Sheets 

by a Multiplicity of Spatially 

Overlapping, Minimally Interfering 

Nondiffracting Optical Beams’’ (HHS 

Reference No. E–118–2010/0–US–01) 

Licensing Status: Available for 

licensing. 

Licensing Contacts: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov 

• Michael Shmilovich, Esq.; 301– 

435–5019; shmilovm@mail.nih.gov 

Collaborative Research Opportunity: 

The NIBIB Section on High Resolution 

Optical Imaging is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize the nondiffracting Light 

Sheets for SPIM. Please contact Hari 

Shroff at 301–435–1995 or 

hari.shroff@nih.gov for more 

information. 

Dated: April 14, 2011. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2011–9571 Filed 4–19–11; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Environmental 

Health Sciences; Amended Notice of 

Meeting 

Notice is hereby given of a change in 

the meeting of the Board of Scientific 

Counselors, NIEHS, March 20, 2011, 7 

p.m. to March 22, 2011, 12:30 p.m., 

Doubletree Guest Suites, 2515 Meridian 

Parkway, Research Triangle Park, NC, 

27713 which was published in the 

Federal Register on February 23, 2011, 

76 FR 36. 

This Federal Register Notice has been 

amended to change the meeting date. 

The meeting will be held Sunday, May 

22, 2011 at 7 p.m. through Tuesday, 

May 24, 2011 at 12:30 p.m. The meeting 

is partially Closed to the public. 

Dated: April 12, 2011. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2011–9492 Filed 4–19–11; 8:45 am] 

BILLING CODE 4140–01–P 


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