Maternal Statistics / Treatment GroupKEY: S#,M# Gp# = code for blind treatmentsTWtGN = Total Weight gain during pregnancy#Fet = number of fetuses in the litter#Res = number of resoprtion sites (no fetus) in the uterine horn#Imp = number of implantation sites (no fetus)in the uterine hornN Hrt = number of fetuses with Normal HeartsAbnHrt = number of fetuses with Abnormal HeartsAbnormalites = the type of cardiac defect seen1100 ppm Trichloroethylene - Pregnancy Only Drinking waterS# M# Gp# TWtGn #Fet #Res #Imp N Hrt AbnHrt Abnormalities6 73 16 121 16 0 1 16 06 74 16 106 8 2 0 7 1 1-ASD, VSD6 75 16 139 14 0 0 13 1 1-ASD6 76 16 158 20 1 0 17 3 1-A-V canal(VSD); 2-ASD; 3-ASD6 77 16 120 10 2 1 10 06 78 16 122 15 0 0 13 2 1-ASD; 2-AorticV-unicuspid, VSD6 80 16 94 7 1 0 6 1 1-AorticV-fenestrated ant. leaflet6 81 16 94 3 0 0 3 0Page 16811694300306 82 16 134 12 5 0 9 3 1-ASD, VSD; 2-VSD-two muscular; 3-ASDStats9 121 105 11 2 94 111.5 ppm Trichloroethylene - Pregnancy only Drinking waterS# M# Gp# TWtGn #Fet #Res #Imp N Hrt AbnHrt Abnormalities6 85 17 96 4 0 0 4 06 86 17 154 14 1 0 14 06 88 17 109 13 1 0 13 06 89 17 143 14 0 0 14 06 90 17 127 16 0 0 16 06 92 17 158 15 0 0 13 2 1-L transposition; 2-VSD-subaortic6 93 17 127 16 0 0 15 1 1-Absent RPA,PA and AO parallel,small PA6 94 17 136 14 0 0 14 06 96 17 183 17 0 0 14 3 1-ASD; 2-ASD; 3-VSD6 97 17 116 11 1 0 9 2 1-VSD-apical and muscular; 2-ASD9 4 17 135 13 3 0 13 09 11 17 134 17 0 0 17 09 33 17 142 17 0 0 16 1 1-ASDStats13 135 181 6 0 172 9Page 1Maternal Statistics / Treatment Group250 ppb Trichloroethylene - Drinking water, Pregnancy OnlyS# M# Gp# TWtGn #Fet #Res #Imp N Hrt AbnHrt Abnormalities20 1 53 124 15 1 0 14 1 1-TriV -small (R8 and R9 twinned-N Hrts)20 5 53 128 10 1 0 10 020 6 53 139 12 1 0 11 1 1-Huge Coronary Sinus20 7 53 125 13 1 0 11 2 1-AoV-dysplastic, no coronary; 2-Tri/MitrV-abn20 8 53 155 17 0 0 17 020 11 53 166 14 6 0 14 020 12 53 167 16 0 0 16 020 13 53 61 1 0 0 1 020 23 53 False pregnancy20 19 53 116 12 1 0 11 1 1-ASDStats10 131.22 110 11 0 105 52.5 ppb TCE in Pregnancy Only Drinking WaterS# M# Gp# TWtGn #Fet #Res #Imp N Hrt AbnHrt Abnormalities22 8 52 127 11 0 0 11 0Page 222852127110011022 10 52 140 13 2 0 13 022 12 52 137 13 1 0 13 022 13 52 115 10 2 0 10 022 14 52 125 14 0 0 14 022 15 52 134 13 1 0 13 022 17 52 120 14 1 0 14 022 20 52 108 12 1 0 12 022 21 52 107 7 0 0 7 022 40 52 127 13 0 0 13 022 43 52 118 12 2 0 12 022 45 52 128 12 0 0 12 0Stats12 123.83 144 10 0 144 0Page 2Maternal Statistics / Treatment GroupControlS# M# Gp# #Fet N Hrt AbnHrt Abnormalities4 4 0.2 14 11 3 1- VSD, ECD-vent.attachmts, 2- D-loop in Rt Chest, 3- D-loop in Rt Chest4 24 0.2 12 11 1 1- VSD9 23 0.2 3 2 1 1- VSD-hi subAO9 26 0.2 12 11 1 1- ASD9 28 0.2 9 8 1 1- VSD lg muscular17 16 0.2 13 12 1 1-ASD, Mitravl V-leaflet atresia19 55 0.2 17 15 2 1-ASD, 2-ASD20 15 0.2 14 12 2 1-ASD, 2-ASD, large23 16 0.2 13 12 1 1-ASD4 1 0.2 11 11 04 10 0.2 10 10 04 12 0.2 15 15 04 14 0.2 11 11 04 22 0.2 19 19 05 5 0.2 11 11 05 15 0.2 11 11 05 21 0.2 12 12 0Page 35210.2121206 84 0.2 4 4 06 109 0.2 12 12 09 2 0.2 5 5 09 3 0.2 14 14 09 5 0.2 14 14 09 12 0.2 13 13 09 27 0.2 17 17 012 8 0.2 15 15 017 8 0.2 16 16 017 19 0.2 9 9 017 24 0.2 12 12 019 10 0.2 8 8 019 25 0.2 7 7 019 35 0.2 5 5 019 43 0.2 9 9 019 57 0.2 5 5 019 59 0.2 12 12 020 18 0.2 4 4 020 20 0.2 8 8 020 22 0.2 10 10 021 11 0.2 13 13 0Page 3Maternal Statistics / Treatment Group22 1 0.2 12 12 022 6 0.2 9 9 022 9 0.2 12 12 022 18 0.2 13 13 022 31 0.2 11 11 022 44 0.2 12 12 023 1 0.2 11 11 023 3 0.2 12 12 023 6 0.2 16 16 023 19 0.2 15 15 023 21 0.2 2 2 023 23 0.2 12 12 023 30 0.2 1 1 023 31 0.2 12 12 023 33 0.2 14 14 023 35 0.2 10 10 023 36 0.2 13 13 055 606 593 13Page 455 litters total 606 Fetuses total9 litters with fetuses with abnormal hearts out of the 55 total litters13 Fetuses with abnormal hearts in 9 Litters593 Normal Fetuses in 46 LittersControl Summary (No statistical sign between groups over time, so controls were thus combined)606 fetuses /55 maternal rats total9 litters with fetuses with abnormal hearts out of the 55 total litters13/606 fetuses with abnormal heartsPage 4