EX-4.3





 Exhibit 4.3 

Stryker Corporation 

and 
 U.S. Bank National
Association, 
 as Trustee 

Sixteenth Supplemental Indenture 

Dated as of November 30, 2018 

to Senior Debt Indenture 
 Dated as
of January 15, 2010 
 Establishing a series of Securities designated 

2.125% Notes due 2027 












 Table of Contents 

 

					
	 	  	 	  	Page
	
	 ARTICLE I

	
	 DEFINITIONS AND INCORPORATION BY REFERENCE

			
	 Section 1.01
	  	Relation to Base Indenture	  	1
	 Section 1.02
	  	Definitions	  	2
	
	 ARTICLE II

	
	 CREATION, FORMS, TERMS AND CONDITIONS OF THE
SECURITIES

			
	 Section 2.01
	  	Creation of the Notes	  	8
	 Section 2.02
	  	Form of the Notes	  	8
	 Section 2.03
	  	Terms and Conditions of the Notes	  	9
	 Section 2.04
	  	Ranking	  	11
	 Section 2.05
	  	Sinking Fund	  	11
	 Section 2.06
	  	Place of Payment	  	11
	 Section 2.07
	  	Transfer and Exchange	  	11
	 Section 2.08
	  	Cancellation and/or Adjustment of Global Notes	  	12
	
	 ARTICLE III

	
	 REDEMPTION OF THE NOTES

			
	 Section 3.01
	  	Optional Redemption by Company	  	12
	 Section 3.02
	  	Optional Redemption for Tax Reasons	  	13
	 Section 3.03
	  	Payment of Additional Amounts	  	13
	
	 ARTICLE IV

	
	 CHANGE OF CONTROL

			
	 Section 4.01
	  	Repurchase at the Option of Holders Upon Change of Control Repurchase Event	  	16
	
	 ARTICLE V

	
	 COVENANTS

			
	 Section 5.01
	  	Limitation on Liens	  	18
	 Section 5.02
	  	Limitations on Sale and Leaseback Transactions	  	18


  
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	 ARTICLE VI
	  

	
	 MISCELLANEOUS PROVISIONS
	  

			
	 Section 6.01
	  	 Ratification of Base Indenture
	  	 	19	 
	 Section 6.02
	  	 Conflict with Trust Indenture Act
	  	 	19	 
	 Section 6.03
	  	 Effect of Headings
	  	 	19	 
	 Section 6.04
	  	 Successors and Assigns
	  	 	19	 
	 Section 6.05
	  	 Separability Clause
	  	 	19	 
	 Section 6.06
	  	 Governing Law
	  	 	20	 
	 Section 6.07
	  	 Counterparts
	  	 	20	 


  
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 SIXTEENTH SUPPLEMENTAL INDENTURE, dated as of November 30, 2018 (this “Sixteenth
Supplemental Indenture”) between Stryker Corporation, a corporation duly organized and existing under the laws of the State of Michigan (herein called the “Company”), having its principal office at 2825 Airview Boulevard, Kalamazoo,
Michigan, and U.S. Bank National Association, a nationally chartered banking association, as trustee (herein called the “Trustee”). 

RECITALS OF THE COMPANY 

WHEREAS, the Company and the Trustee have heretofore executed and delivered an Indenture, dated as of January 15, 2010 (the “Base
Indenture” and, together with this Sixteenth Supplemental Indenture, the “Indenture”), providing for the issuance from time to time of the Company’s debentures, notes or other evidences of indebtedness (herein and therein called
the “Securities”), to be issued in one or more series as provided in the Base Indenture; 
 WHEREAS, Section 901 of the Base
Indenture permits the Company and the Trustee to enter into a supplemental indenture to the Base Indenture to establish the form and terms of any series of Securities; 

WHEREAS, Section 201 of the Base Indenture permits the form of Securities of any series to be established in a supplemental indenture to
the Base Indenture; 
 WHEREAS, Section 301 of the Base Indenture permits certain terms of any series of Securities to be established
pursuant to a supplemental indenture to the Base Indenture; 
 WHEREAS, pursuant to Sections 201 and 301 of the Base Indenture, the Company
desires to provide for the establishment of a new series of Securities in an aggregate principal amount of €750,000,000 to be designated the “2.125% Notes due 2027 (hereinafter called the “Notes”) under the Base Indenture, the
form and substance of such Notes and the terms, provisions and conditions thereof to be set forth as provided in the Base Indenture and this Sixteenth Supplemental Indenture; and 

WHEREAS, all things necessary to make this Sixteenth Supplemental Indenture a valid agreement of the Company, in accordance with its terms,
have been done; 
 NOW, THEREFORE, for and in consideration of the foregoing and the purchase of the Notes established by this Sixteenth
Supplemental Indenture by the holders thereof (the “Holders”), it is mutually agreed, for the equal and proportionate benefit of all such Holders, as follows: 

ARTICLE I 

DEFINITIONS AND INCORPORATION BY REFERENCE 

Section 1.01 Relation to Base Indenture. This Sixteenth Supplemental Indenture constitutes a part of the Base Indenture (the
provisions of which, as modified by this Sixteenth Supplemental Indenture, shall apply to the Notes) in respect of the Notes but shall not modify, amend or otherwise affect the Base Indenture insofar as it relates to any other series of Securities
or modify, amend or otherwise affect in any manner the terms and conditions of the Securities of any other series. 












 Section 1.02 Definitions. For all purposes of this Sixteenth Supplemental
Indenture, the capitalized terms used herein (i) which are defined in this Section 1.02 have the respective meanings assigned hereto in this Section 1.02 and (ii) which are defined in the Base Indenture (and which are not defined
in this Section 1.02) have the respective meanings assigned thereto in the Base Indenture. For all purposes of this Sixteenth Supplemental Indenture: 

(a) Unless the context otherwise requires, any reference to an Article or Section refers to an Article or Section, as the case may be, of this
Sixteenth Supplemental Indenture; 
 (b) The words “herein,” “hereof” and “hereunder” and words of similar
import refer to this Sixteenth Supplemental Indenture as a whole and not to any particular Article, Section or other subdivision; 
 (c)
Headings are for convenience or reference only and do not affect interpretations; and 
 (d) The terms defined in this Section 1.02(d)
have the meanings assigned to them in this Section and include the plural as well as the singular: 
 “Applicable Procedures” has
the meaning set forth in Section 2.07(a). 
 “Attributable Debt” in respect of a Sale and Leaseback Transaction means, at the
time of determination, the present value (discounted at the imputed rate of interest of such transaction as determined in good faith by the Company) of the obligation of the lessee for net rental payments during the remaining term of the lease
included in such Sale and Leaseback Transaction (including any period for which such lease has been extended or may, at the option of the lessor, be extended). The term “net rental payments” under any lease for any period means the sum of
the rental and other payments required to be paid in such period by the lessee thereunder, not including any amounts required to be paid by such lessee (whether or not designated as rental or additional rent) on account of maintenance and repairs,
insurance, taxes, assessments, water rates or similar charges required to be paid by such lessee thereunder or any amount required to be paid by lessee thereunder contingent upon the amount of maintenance and repairs, insurance, taxes, assessments,
water rates or similar charges. In the case of any lease that is terminable by the lessee upon the payment of a penalty, such net amount shall be the lesser of (x) the net amount determined assuming termination upon the first date such lease
may be terminated (in which case the net amount shall also include the amount of the penalty, but shall not include any rent that would be required to be paid under such lease subsequent to the first date upon which it may be so terminated) or
(y) the net amount determined assuming no such termination. 
 “Base Indenture” has the meaning given to such term in the
recitals hereof. 

  
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 “Below Investment Grade Rating Event” means the Notes are rated below Investment
Grade by each of the Rating Agencies on any date during the period commencing upon the first public notice of the occurrence of a Change of Control or the Company’s intention to effect a Change of Control and ending 60 days following public
notice of the occurrence of the related Change of Control (which period shall be extended so long as the rating of the Notes is under publicly announced consideration for possible downgrade by any of the Rating Agencies, provided that no such
extension shall occur if on such 60th day the Notes are rated Investment Grade by at least one of such Rating Agency and are not subject to review for possible downgrade by such Rating Agency);
provided further that a Below Investment Grade Rating Event otherwise arising by virtue of a particular reduction in rating shall not be deemed to have occurred in respect of a particular Change of Control (and thus shall not be deemed a Below
Investment Grade Rating Event for purposes of the definition of Change of Control Repurchase Event hereunder) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or
inform the Trustee in writing at its request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of Control (whether or not the
applicable Change of Control shall have occurred at the time of the Below Investment Grade Rating Event). 
 “Business Day” means
any day, other than a Saturday or Sunday, that is neither a legal holiday nor a day on which the Trustee or banking institutions in New York City, London or another place of payment on the Notes are authorized or required by law or regulation to
close and on which the Trans-European Automated Real-Time Gross Settlement Express Transfer system (the “TARGET2” system), or any successor thereto, is open. 

“Change of Control” means the occurrence of any of the following: 

1. the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in
one or a series of related transactions, of all or substantially all of the Company’s assets and those of the Company’s Subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange
Act), other than the Company or one of the Company’s Subsidiaries; 
 2. the adoption of a plan relating to the
Company’s liquidation or dissolution; 
 3. the first day on which a majority of the members of the Company’s Board
of Directors are not Continuing Directors; or 
 4. the consummation of any transaction (including, without limitation, any
merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Company or one or more of its Subsidiaries, becomes the beneficial owner (as defined in
Rule 13d-3 of the Exchange Act), directly or indirectly, of more than 50% of the then outstanding number of shares of the Company’s Voting Stock. 

Notwithstanding the foregoing, a transaction shall not be considered to be a Change of Control if (a) the Company becomes a direct or
indirect wholly-owned subsidiary of a holding company and (b)(i) immediately following that transaction, the direct or indirect holders of the Voting Stock of the holding company are substantially the same as the holders of the Company’s Voting
Stock immediately prior to that transaction or (ii) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more than 50% of the Voting Stock of such holding company. 

  
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 “Change of Control Repurchase Event” means the occurrence of both a Change of
Control and a Below Investment Grade Rating Event. 
 “Clearstream” means Clearstream Banking, S.A. 

“Common Depositary” means Elavon Financial Services DAC, as common depositary for the Depositary. 

“Company” has the meaning given to such term in the preamble hereof. 

“Comparable Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an
independent investment bank selected by the Company (the “Quotation Agent”), a German government bund whose maturity is closest to the par call date, or if such Quotation Agent in its discretion determines that such similar bond is not in
issue, such other German government bund as such Quotation Agent may, with the advice of three brokers of, and/or market makers in, German government bunds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate. 
 “Comparable Government Bond Rate” means the price, expressed as a percentage (rounded to three decimal
places, with 0.0005 being rounded upwards), at which the gross redemption yield on the Notes to be redeemed, if they were to be purchased at such price on the third business day prior to the date fixed for redemption, would be equal to the gross
redemption yield on such business day of the Comparable Government Bond on the basis of the middle market price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such business day as determined by the Quotation Agent
selected by the Company. 
 “Consolidated Net Tangible Assets” means the total amounts of assets (less depreciation and valuation
reserves and other reserves and items deductible from gross book value of specific asset accounts under generally accepted accounting principles) that under generally accepted accounting principles would be included on a consolidated balance sheet
of the Company and its consolidated Restricted Subsidiaries after deducting (1) all current liabilities, excluding current liabilities that could be classified as long-term debt under generally accepted accounting principles and current
liabilities that are by their terms extendable or renewable at the obligor’s option to a time more than 12 months after the time as of which the amount of current liabilities is being computed; (2) Investments in Unrestricted Subsidiaries;
and (3) all trade names, trademarks, licenses, patents, copyrights and goodwill, organizational and development costs, deferred charges, other than prepaid items such as insurance, taxes, interest, commissions, rents and similar items and
tangible assets being amortized, and amortized debt discount and expense, less unamortized premium. 
 “Continuing Directors”
means, as of any date of determination, any member of the Company’s Board of Directors who (1) was a member of such Board of Directors on the date of the issuance of the Notes; or (2) was nominated for election, elected or appointed
to such Board of Directors with the approval of a majority of the Continuing Directors who were members of such Board of Directors at the time of such nomination, election or appointment (either by a specific vote or by approval of the
Company’s proxy statement in which such member was named as a nominee for election as a director). 

  
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 “Definitive Notes” means certificated Notes registered in the name of the Holder
thereof and issued in accordance with Section 2.02 hereof, substantially in the form of Exhibit A hereto, except that such Security shall not bear the Global Note Legend. 

“Depositary” means, with respect to Global Notes issued under this Sixteenth Supplemental Indenture, each of Clearstream and
Euroclear. 
 “Euro” and “€” means the single currency introduced at the third stage of the European Monetary Union
pursuant to the Treaty establishing the European Community, as amended. 
 “Euroclear” means Euroclear Bank SA/NV, as operator of
the Euroclear System. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended from time to time. 

“Exempted Debt” means the sum of the following items outstanding as of the date Exempted Debt is being determined
(1) Indebtedness of the Company and its Restricted Subsidiaries secured by a Mortgage and not permitted to exist under the Indenture and (2) Attributable Debt of the Company and its Restricted Subsidiaries in respect of all Sale and
Leaseback Transactions not permitted under the Indenture. 
 “Funded Debt” means Indebtedness that matures more than one year from
the date of creation, or that is extendable or renewable at the sole option of the obligor so that it may become payable more than one year from such date. Funded Debt does not include (1) obligations created pursuant to leases, (2) any
Indebtedness or portion thereof maturing by its terms within one year from the time of any computation of the amount of outstanding Funded Debt unless such Indebtedness shall be extendable or renewable at the sole option of the obligor in such
manner that it may become payable more than one year from such time, or (3) any Indebtedness for the payment or redemption of which money in the necessary amount shall have been deposited in trust either at or before the maturity date thereof.

 “Global Note” means a single permanent fully-registered global note in book-entry form, without coupons, substantially in the
form of Exhibit A attached hereto. 
 “Global Note Legend” means the legend set forth in Section 202 of the Base Indenture.

 “Holders” has the meaning given to such term in the recitals hereof. 

“Indebtedness” means any and all of the obligations of a Person for money borrowed that in accordance with generally accepted
accounting principles would be reflected on the balance sheet of such Person as a liability as of the date of which the Indebtedness is to be determined. For the avoidance of doubt, a change in generally accepted accounting principles subsequent to
the issue date of the Notes shall not be deemed an incurrence of Indebtedness. 
 “Indenture” has the meaning given to such term
in the recitals hereof. 

  
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 “Indirect Participant” means a Person who holds a beneficial interest in a Global
Note through a Participant. 
 “Interest Payment Date” has the meaning set forth in Section 2.03(c). 

“Investment” means any investment in stock, evidences of Indebtedness, loans or advances, however made or acquired, but does not
include the Company’s account receivable or the accounts receivable of any Restricted Subsidiary arising from transactions in the ordinary course of business, or any evidences of Indebtedness, loans or advance made in connection with the sale
to any Subsidiary of the Company’s accounts receivable or the accounts receivable of any Restricted Subsidiary arising from transactions in the ordinary course of business. 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating categories of
Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency
or Rating Agencies selected by the Company. 
 “Maturity Date” has the meaning set forth in Section 2.03(b) hereof. 

“Moody’s” means Moody’s Investors Service Inc., a subsidiary of Moody’s Corporation, and its successors. 

“Mortgage” means any mortgage, security interest, pledge, lien or other encumbrance. 

“Notes” has the meaning given to such term in the recitals hereof. 

“Participant” means, with respect to the Depositary, a Person who has an account with the Depositary. 

“Permitted Mortgage” means (a) any purchase money mortgage on such Principal Property prior to, simultaneously with or within
180 days after the later of (1) the acquisition or completion of construction or completion of substantial reconstruction, renovation, remodeling, expansion or improvement (each, a “substantial improvement”) of such Principal Property
or (2) the placing in operation of such property after the acquisition or completion of any such construction or substantial improvement; (b) Mortgages on a Principal Property existing at the time of acquisition, including acquisition
through merger or consolidation; (c) Mortgages existing on the date of the initial issuance of the Notes, Mortgages on assets of a corporation or other business entity existing on the date it becomes a Restricted Subsidiary or is merged or
consolidated with the Company or a Restricted Subsidiary or at the time the corporation or other business entity sells, leases or otherwise disposes of its property as an entirety or substantially as an entirety to the Company or a Restricted
Subsidiary or Mortgages on the assets of a Subsidiary that is newly designated as a Restricted Subsidiary if the Mortgage would have been permitted under the provisions of this paragraph if such Mortgage was created while the Subsidiary was a
Restricted Subsidiary; (d) Mortgages in favor of the Company or a Restricted Subsidiary; (e) Mortgages for taxes, assessments or governmental charges or levies that are not delinquent or that are being contested in good faith;
(f) carriers’, warehousemen’s, materialmen’s, repairmen’s, mechanic’s, landlords’ and other similar Mortgages arising in ordinary course of business that are not delinquent or remain payable without penalty or that
are being contested in good faith; 

  
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(g) Mortgages (other than any Mortgage imposed by the Employee Retirement Income Security Act of 1974) consisting of pledges or deposits required in the ordinary course of business in connection
with workers’ compensation, unemployment insurance and other social security legislation; (h) easements, rights-of-way, restrictions, encroachments,
imperfections and other similar encumbrances affecting real property that, in the aggregate, are not substantial in amount and do not in any case materially detract from the value of the Principal Property subject thereto or materially interfere
with the ordinary conduct of the Company and its Subsidiaries’ business, taken as a whole; (i) Mortgages arising by reason of deposits with, or the giving of any form of security to, any governmental agency or any body created or approved
by law or governmental regulation, including any zoning or similar law or right reserved to or vested in any governmental office or agency to control or regulate the use of any real property; (j) Mortgages arising from filing Uniform Commercial
Code financing statements relating solely to leases; and (k) Mortgages to secure Indebtedness incurred to extend, renew, refinance or replace Indebtedness secured by any Mortgages referred to above, provided that the principal amount of the
extended, renewed, refinanced or replaced Indebtedness does not exceed the principal amount of Indebtedness so extended, renewed, refinanced or replaced, plus transaction costs and fees, and that any such Mortgage applies only to the same property
or assets subject to the prior permitted Mortgage (and, in the case of real property, improvements). 
 “Principal Property” means
all real property and improvements thereon owned by the Company or a Restricted Subsidiary, including, without limitation, any manufacturing, warehouse, distribution or research facility, and improvements therein, having a net book value in excess
of 2% of Consolidated Net Tangible Assets that is located within the United States, excluding its territories and possessions and Puerto Rico. This term does not include any real property and improvements thereon that the Company’s Board of
Directors declares by resolution not to be of material importance to the total business conducted by the Company and its Restricted Subsidiaries taken as a whole. 

“Rating Agency” means (1) each of Moody’s and S&P; and (2) if any of Moody’s or S&P ceases to rate the
Notes or fails to make a rating of the Notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) under the Exchange
Act, selected by the Company as a replacement agency for Moody’s or S&P, or both of them, as the case may be. 
 “Regular
Record Date” has the meaning set forth in Section 2.03(c). 
 “Redemption Date” means the Business Day on which Notes
are redeemed by the Company pursuant to Section 3.01 hereof. 
 “Redemption Price” has the meaning set forth in
Section 3.01(a). 
 “Registered Securities” means any Securities which are registered in the Security Register. 

“Restricted Subsidiary” means a Subsidiary that owns a Principal Property. 

“S&P” means S&P Global Ratings Inc., a division of S&P Global Inc. and its successors. 

  
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 “Sale and Leaseback Transaction” means an arrangement with any Person providing
for the leasing by the Company or any Restricted Subsidiary of any Principal Property owned or acquired thereafter that has been or is to be sold or transferred by the Company or such Restricted Subsidiary to such Person with the intention of taking
back a lease of such Principal Property. 
 “Securities” has the meaning given to such term in the recitals hereof. 

“Senior Funded Debt” means all Funded Debt (except Funded Debt, the payment of which is subordinated to the payment of the Notes).

 “Subsidiary” means a corporation, partnership or other legal entity of which, in the case of a corporation, more than 50% of
the outstanding voting stock is owned, directly or indirectly, by the Company or by one or more other Subsidiaries, or by the Company and one or more other Subsidiaries or, in the case of any partnership or other legal entity, more than 50% of the
ordinary capital interests is, at the time, directly or indirectly owned or controlled by the Company or by one or more other Subsidiaries. For the purposes of this definition, “voting stock” means the equity interest that ordinarily has
voting power for the election of directors, managers or trustees of an entity, or persons performing similar functions, whether at all times or only so long as no senior class of equity interest has such voting power by reason of any contingency.

 “Trustee” has the meaning given to such term in the preamble hereof. 

“Unrestricted Subsidiary” means any Subsidiary other than a Restricted Subsidiary. 

“Voting Stock” of any specified Person as of any date means the capital stock of such Person that is at the time entitled to vote
generally in the election of the board of directors of such Person. 
 ARTICLE II 

CREATION, FORMS, TERMS AND CONDITIONS OF THE SECURITIES 

Section 2.01 Creation of the Notes. In accordance with Section 301 of the Base Indenture, the Company hereby creates the
Notes as a separate series of its securities issued pursuant to the Indenture. The Notes shall be issued initially in an aggregate principal amount of €750,000,000, except as permitted by Sections 304, 305 or 306 of the Base Indenture. 

Section 2.02 Form of the Notes. The Notes shall each be issued in the form of a Global Note, duly executed by the Company and
authenticated by the Trustee, which shall be deposited with, or on behalf of, the Common Depositary and shall be registered in the name of “Elavon Financial Services DAC”, or its nominee, for, and in respect of interests held through, the
Depositary. The Notes shall be substantially in the form of Exhibit A attached hereto (including the Global Note Legend thereon). Notes issued in definitive certificated form in accordance with the terms of the Base Indenture and this Sixteenth
Supplemental Indenture, if any, shall be substantially in the form of Exhibit A attached hereto (but without the Global Note Legend thereon). 

  
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 So long as the Common Depositary, or its nominee, is the registered owner of a Global Note, the Common
Depositary or its nominee, as the case may be, shall be considered the sole owner or Holder of the Notes represented by such Global Note for all purposes under the Indenture. Ownership of beneficial interests in such Global Note shall be shown on,
and transfers thereof shall be effected only through, records maintained by the Depositary (with respect to beneficial interests of participants) or by participants or Persons that hold interests through participants (with respect to beneficial
interests of beneficial owners). In addition, the following provisions of clauses (1), (2), and (3) below shall apply only to Global Notes: 

1. Notwithstanding any other provision in the Indenture, no Global Note may be exchanged in whole or in part for Securities
registered, and no transfer of a Global Note in whole or in part may be registered, in the name of any Person other than the Depositary for such Global Note or a nominee thereof unless (A) such Depositary has notified the Company that it is
unwilling or unable or no longer permitted under applicable law to continue as Depositary for such Global Note and the Company has not appointed a successor Depositary within 90 days of receipt of such notice or has ceased to be a clearing agency
registered under the Exchange Act, (B) there shall have occurred and be continuing an Event of Default with respect to such Global Note or (C) the Company (subject to the procedures of the Depositary) so directs the Trustee by Company
Order. Beneficial interests in Global Notes may be exchanged for Definitive Notes of the same series upon request but only upon at least 30 days’ prior written notice given to the Trustee by or on behalf of the Depositary in accordance with
customary procedures. 
 2. Subject to clause (1) above, any exchange of a Global Note for other Securities may be made
in whole or in part, and all Securities issued in exchange for a Global Note or any portion thereof shall be registered in such names as the Depositary for such Global Note shall direct. 

3. Every Security authenticated and delivered upon registration of transfer of, or in exchange for or in lieu of, a Global Note
or any portion thereof, shall be authenticated and delivered in the form of, and shall be, a Global Note, unless such note is registered in the name of a Person other than the Depositary for such Global Note or a nominee thereof. 

Section 2.03 Terms and Conditions of the Notes. The Notes shall be governed by all the terms and conditions of the Base Indenture,
as supplemented by this Sixteenth Supplemental Indenture. In particular, the following provisions shall be terms of the Notes: 
 (a)
Title and Aggregate Principal Amount. The title of the Notes shall be as specified in the Recitals of the Company; and the aggregate principal amount of the Notes shall be as specified in Section 2.01 of this Article II, except as
permitted by Sections 304, 305 or 306 of the Base Indenture. 
 (b) Stated Maturity. The Notes shall mature, and the unpaid
principal thereon shall be payable, on November 30, 2027 (the “Maturity Date”), subject to the provisions of the Base Indenture and Articles III and IV below. 

  
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 (c) Interest. The rate per annum at which interest shall be payable on the Notes
shall be 2.125%. Interest on the Notes shall be payable annually in arrears on November 30 of each year, commencing on November 30, 2019 (the “Interest Payment Date”), to the Persons in whose names the applicable Notes are
registered in the Security Register applicable to the Notes at the close of business on the business day (for this purpose, a day on which Clearstream and Euroclear are open for business) immediately preceding the applicable Interest Payment Date
(each, a “Regular Record Date”). Interest on the Notes shall be computed on the basis of the actual number of days in the period for which interest is being calculated and the actual number of days from and including the last date on which
interest was paid on the Notes (or November 30, 2018, if no interest has been paid on the Notes), to, but excluding, the next scheduled Interest Payment Date. Interest on the Notes shall accrue from and including November, 2018. If an Interest
Payment Date or the Maturity Date falls on a day that is not a Business Day, the payment shall be made on the next Business Day as if it were made on the date the payment was due, and no interest shall accrue on the amount so payable for the period
from and after that Interest Payment Date or the Maturity Date, as the case may be, to the date the payment is made. Interest payments shall include accrued interest from and including the date of issue or from and including the last date in respect
to which interest has been paid, as the case may be, to, but excluding, the Interest Payment Date or the Maturity Date, as the case may be. 

(d) Registration and Form. The Notes shall be issuable as Registered Securities as provided in Section 2.02 of this Article II.
The Notes shall be issued and may be transferred only in minimum denominations of €100,000 and integral multiples of €1,000 thereafter. Principal of and interest on the Notes will be payable, and the Notes will be transferable or
exchangeable, at the office or offices or agency maintained by the Company for these purposes. Payment of interest on the Notes may be made at the Company’s option by check mailed to the registered holders thereof. 

(e) Defeasance and Covenant Defeasance. The provisions for defeasance in Section 1302 of the Base Indenture, and the provisions
for covenant defeasance in Section 1303 of the Base Indenture, shall be applicable to the Notes. 
 (f) Further Issues.
Notwithstanding anything to the contrary contained herein or in the Base Indenture, the Company may, from time to time, without notice to, or the consent of, the Holders, create and issue additional Notes of this series having the same ranking and
terms and conditions as the Notes in all respects, except for the issue date, the public offering price and, in some cases, the first Interest Payment Date (the “Additional Notes”). Any Additional Notes having similar terms, together with
the Notes of this series shall be consolidated with and shall form a single series with the previously outstanding Notes. If the Additional Notes are not fungible with the previously outstanding Notes for U.S. federal income tax purposes, the
Additional Notes will have a separate CUSIP number. Notice of any such issuance shall be given to the Trustee and a new supplemental indenture shall be executed in connection with the issuance of such additional Notes. 

(g) Other Terms and Conditions. The Notes shall have such other terms and conditions as provided in the form thereof attached as
Exhibit A. 

  
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 Section 2.04 Ranking. The Notes shall be general unsecured obligations of the
Company. The Notes shall rank pari passu in right of payment with all unsecured and unsubordinated indebtedness, including, without limitation, any unsecured senior indebtedness, of the Company and senior in right of payment to all subordinated
indebtedness of the Company. 
 Section 2.05 Sinking Fund. The Notes shall not be entitled to any sinking fund. 

Section 2.06 Place of Payment. The Place of Payment in respect of the Notes will be at the office or agency of the Company in the
City of New York, State of New York or at the office or agency of the Paying Agent maintained for such purposes in the city of London, initially 125 Old Broad Street, Fifth Floor, London EC2N 1AR. 

Section 2.07 Transfer and Exchange. 

(a) The transfer and exchange of beneficial interests in the Global Notes shall be effected through the Depositary, in accordance with the
provisions of the Base Indenture, this Sixteenth Supplemental Indenture and the then applicable procedures of the Depositary (the “Applicable Procedures”). Any Holder of a Global Note shall, by acceptance of such Global Note, agree that
the transfers of beneficial interests in such Global Note may be effected only through book-entry procedures maintained by the Common Depositary, and that, except as provided for in Article II of the Base Indenture, ownership of a beneficial
interest in the Notes represented thereby shall be required to be reflected in book-entry form. Transfers of a Global Note shall be limited to transfers in whole and not in part, to the Common Depositary, its successors and their respective
nominees. Interests of beneficial owners in a Global Note shall be transferred in accordance with the Applicable Procedure of the Depositary or its successor. Upon satisfaction of all of the requirements for transfer or exchange of beneficial
interests in Global Notes contained in the Base Indenture, this Sixteenth Supplemental Indenture and the Notes or otherwise applicable under the Securities Act, the Security Registrar shall adjust the principal amount of the relevant Global Notes
pursuant to Section 2.08 hereof. 
 (b) Upon request by a Holder of Definitive Notes and such Holder’s compliance with the
provisions of this Section 2.07(b), the Security Registrar shall register the transfer or exchange of Definitive Notes. Prior to such registration of transfer or exchange, the requesting Holder shall present or surrender to the Trustee the
Definitive Notes duly endorsed or accompanied by a written instruction of transfer in form satisfactory to the Security Registrar duly executed by such Holder or by its attorney, duly authorized in writing. The Trustee shall cancel any such
Definitive Notes so surrendered, and the Company shall execute and, upon receipt of a Company Order pursuant to Section 303 of the Base Indenture, the Trustee shall authenticate and deliver to the Person designated in the instructions a new
Definitive Note in the appropriate principal amount. Any Definitive Note issued pursuant to this Section 2.07(b) shall be registered in such name or names and in such authorized denomination or denominations as the Holder of such beneficial
interest shall instruct the Security Registrar through instructions from the Depositary and the Participant or Indirect Participant. The Trustee shall deliver such Definitive Notes to the Persons in whose names such Definitive Notes are so
registered. In addition, the requesting Holder shall provide any additional certifications, documents and information, as applicable, required pursuant to Section 305 of the Base Indenture. 

  
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 Section 2.08 Cancellation and/or Adjustment of Global Notes. At such time as all
beneficial interests in a particular Global Note have been exchanged for Definitive Notes or a particular Global Note has been redeemed, repurchased or cancelled in whole and not in part, each such Global Note shall be returned to or retained and
cancelled by the Trustee in accordance with Section 309 of the Base Indenture. At any time prior to such cancellation, if any beneficial interest in a Global Note is exchanged for or transferred to a Person who will take delivery thereof in the
form of a beneficial interest in another Global Note or for Definitive Notes, the principal amount of Securities represented by such Global Note shall be reduced accordingly and an endorsement shall be made on such Global Note by the Trustee or by
the Depositary at the direction of the Trustee to reflect such reduction; and if the beneficial interest is being exchanged for or transferred to a Person who will take delivery thereof in the form of a beneficial interest in another Global Note,
such other Global Note shall be increased accordingly and an endorsement shall be made on such Global Note by the Security Registrar or by the Depositary at the direction of the Security Registrar to reflect such increase. 

ARTICLE III 

REDEMPTION OF THE NOTES 

Section 3.01 Optional Redemption by Company. 

(a) The Company shall have the right to redeem the Notes at any time in whole or from time to time in part, at the Company’s option for
cash prior to August 31, 2027 (the “Par Call Date”) at a redemption price (the “Redemption Price”) equal to the greater of: 

(i) 100% of the principal amount of the Notes to be redeemed; or 

(ii) an amount determined by the Quotation Agent equal to the sum of the present values of the remaining scheduled payments of
principal, premium, if any, and interest thereon (not including any portion of such payments of interest accrued to the date of redemption) to August 31, 2027, discounted to the date of redemption on an annual basis (Actual/Actual (ICMA) at the
Comparable Government Bond Rate, plus 30 basis points; 
 plus, in each case, accrued and unpaid interest thereon to, but not including, the
date of redemption. 
 (b) At any time on or after the Par Call Date, the Company may redeem the Notes, in whole or from time to time in
part, at the Company’s option for cash at a redemption price equal to 100% of the principal amount thereof, plus accrued and unpaid interest thereon to, but not including, the date of redemption. 

(c) Notwithstanding subsections (a) and (b) above, installments of interest on the Notes that are due and payable on any Interest
Payment Date falling on or prior to a Redemption Date shall be payable on such Interest Payment Date to the registered Holders as of the close of business on the relevant Regular Record Date according to the terms of the Notes and the Indenture.
Unless the Company defaults in payment of the Redemption Price, on and after the Redemption Date, interest shall cease to accrue on any Notes or portions thereof that are called for redemption. 

  
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 (d) Notices of redemption shall be mailed (or, in the case of Notes held in book-entry
form, be transmitted electronically) at least ten (10) but not more than sixty (60) days before the Redemption Date to each Holder of the Notes to be redeemed at its registered address. 

(e) If less than all of the Notes are to be redeemed at any time, the Notes to be redeemed will be selected by the Trustee in accordance with
the standard procedures of the Depositary. If the Notes to be redeemed are not Global Notes then held by Euroclear or Clearstream, the Trustee will select the Notes to be redeemed on a pro rata basis. If the Notes are listed on the New York Stock
Exchange (“NYSE”) or any other national securities exchange, the Trustee will select Notes in compliance with the requirements of the NYSE or other principal national securities exchange on which the Notes are listed. Notwithstanding the
foregoing, if less than all of the Notes are to be redeemed, no Notes of such series of a principal amount of €100,000 or less shall be redeemed in part. 

(f) If money sufficient to pay the Redemption Price on the Notes (or portions thereof) to be redeemed on the Redemption Date is deposited
with the Paying Agent on or before the Redemption Date and notice of redemption has been given in accordance with the terms of this Indenture, then on and after such Redemption Date, interest will cease to accrue on the Notes (or such portion
thereof) called for redemption. 
 Section 3.02 Optional Redemption for Tax Reasons 

(a) The Company shall have the right to redeem the Notes at any time in whole, but not in part, on not less than 10 nor more than 60
days’ prior notice, at 100% of the principal amount of the Notes, together with accrued and unpaid interest, if any, to, but excluding, the Redemption Date if, as a result of any change in, or amendment to, the laws, regulations or rulings of
the United States (or any political subdivision or taxing authority thereof or therein having power to tax), or any change in official position regarding application or interpretation of those laws, regulations or rulings (including a holding by a
court of competent jurisdiction), which change, amendment, application or interpretation is announced or becomes effective on or after the original issue date with respect to the Notes, the Company becomes or, based upon a written opinion of
independent counsel selected by the Company, will become obligated to pay additional amounts as described in Section 3.03. 

Section 3.03 Payment of Additional Amounts 

(a) All payments of principal, interest, and premium, if any, in respect of the Notes will be made free and clear of, and without withholding
or deduction for, any present or future taxes, assessments, duties or governmental charges of whatever nature imposed, levied or collected by the United States (or any political subdivision or taxing authority thereof or therein having power to
tax), unless such withholding or deduction is required by law or the official interpretation or administration thereof. 

  
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 (b) The Company will, subject to the exceptions and limitations set forth below, pay as
additional interest in respect of the Notes such additional amounts as are necessary in order that the net payment by the Company of the principal of, premium, if any, and interest in respect of the Notes to a Holder who is not a United States
person (as defined below), after withholding or deduction for any present or future tax, assessment, duties or other governmental charge imposed by the United States (or any political subdivision or taxing authority thereof or therein having power
to tax), will not be less than the amount provided in the Notes to be then due and payable; provided, however, that the foregoing obligation to pay additional amounts shall not apply: 

(i) to the extent any tax, assessment or other governmental charge would not have been imposed but for the Holder (or the
beneficial owner for whose benefit such Holder holds such note), or a fiduciary, settlor, beneficiary, member or shareholder of the Holder if the Holder is an estate, trust, partnership or corporation, or a person holding a power over an estate or
trust administered by a fiduciary holder, being considered as: 
 (1) being or having been engaged in a trade or business in
the United States or having or having had a permanent establishment in the United States; 
 (2) having a current or former
connection with the United States (other than a connection arising solely as a result of the ownership of the Notes, the receipt of any payment in respect of the Notes or the enforcement of any rights hereunder), including being or having been a
citizen or resident of the United States; 
 (3) being or having been a personal holding company, a passive foreign
investment company or a controlled foreign corporation for U.S. federal income tax purposes, a foreign tax-exempt organization, or a corporation that has accumulated earnings to avoid U.S. federal income tax;

 (4) being or having been a “10-percent shareholder” of the Company as
defined in section 871(h)(3) of the United States Internal Revenue Code of 1986, as amended (the “Code”) or any successor provision; or 

(5) being a bank receiving payments on an extension of credit made pursuant to a loan agreement entered into in the ordinary
course of its trade or business, as described in section 881(c)(3)(A) of the Code or any successor provision; 
 (ii) to any
Holder that is not the sole beneficial owner of the Notes, or a portion of the Notes, or that is a fiduciary, partnership, limited liability company or other fiscally transparent entity, but only to the extent that a beneficial owner with respect to
the Holder, a beneficiary or settlor with respect to the fiduciary, or a beneficial owner or member of the partnership, limited liability company or other fiscally transparent entity would not have been entitled to the payment of an additional
amount had the beneficiary, settlor, beneficial owner or member received directly its beneficial or distributive share of the payment; 

  
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 (iii) to the extent any tax, assessment or other governmental charge that
would not have been imposed but for the failure of the Holder or any other person to comply with certification, identification or information reporting requirements concerning the nationality, residence, identity or connection with the United States
of the Holder or beneficial owner of the Notes, if compliance is required by statute, by regulation of the United States or any taxing authority therein or by an applicable income tax treaty to which the United States is a party as a precondition to
exemption from such tax, assessment or other governmental charge; 
 (iv) to any tax, assessment or other governmental
charge that is imposed otherwise than by withholding by the Company or the Paying Agent from the payment; 
 (v) to any tax,
assessment or other governmental charge required to be withheld by the Paying Agent from any payment of principal of or interest on any Notes, if such payment can be made without such withholding by any other paying agent; 

(vi) to any estate, inheritance, gift, sales, transfer, wealth, capital gains or personal property tax or similar tax,
assessment or other governmental charge, or excise tax imposed on the transfer of Notes; 
 (vii) to the extent any tax,
assessment or other governmental charge would not have been imposed but for the presentation by the Holder of any Note, where presentation is required, for payment on a date more than 30 days after the date on which payment became due and payable or
the date on which payment thereof is duly provided for, whichever occurs later except to the extent that the beneficiary or Holder thereof would have been entitled to the payment of additional amounts had such Note been presented for payment on any
day during such 30-day period; 
 (viii) to any tax, assessment or other
governmental charge imposed under sections 1471 through 1474 of the Code (or any amended or successor provisions), any current or future regulations or official interpretations thereof, any agreement entered into pursuant to section 1471(b) of the
Code or any fiscal or regulatory legislation, rules or practices adopted pursuant to any intergovernmental agreement entered into in connection with the implementation of such sections of the Code, whether currently in effect or as published and
amended from time to time; 
 (ix) to any tax, assessment or other governmental charge that is imposed or withheld solely by
reason of a change in law, regulation, or administrative or judicial interpretation that becomes effective more than 15 days after the payment becomes due or is duly provided for, whichever occurs later; or 

  
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 (x) in the case of any combination of the above Sections 3.03(b)(i) –
3.03(b)(xi). 
 (c) As used in Section 3.02, and this Section 3.03, the term “United States” means the United States of
America, its territories and possessions, the states of the United States and the District of Columbia, and the term “United States person” means (i) any individual who is a citizen or resident of the United States for U.S. federal
income tax purposes, (ii) a corporation, partnership or other entity created or organized in or under the laws of the United States, any state of the United States or the District of Columbia (other than a partnership that is not treated as a
United States person for United States federal income tax purposes), (iii) any estate the income of which is subject to U.S. federal income taxation regardless of its source, or (iv) any trust if a United States court can exercise primary
supervision over the administration of the trust and one or more United States persons can control all substantial trust decisions, or if a valid election is in place to treat the trust as a United States person. 

ARTICLE IV 
 CHANGE
OF CONTROL 
 Section 4.01 Repurchase at the Option of Holders Upon Change of Control Repurchase Event. 

(a) If a Change of Control Repurchase Event occurs, unless the Company has exercised its right to redeem the Notes pursuant to the Indenture,
the Company shall be required to make an offer (a “Change of Control Offer”) to each Holder of the Notes to repurchase all or any part (in minimum denominations of €100,000 and integral multiples of €1,000 original principal
amount above that amount) of that Holder’s Notes at a repurchase price in cash equal to 101% of the aggregate principal amount of the Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to, but not including, the
date of such repurchase. 
 (b) Within thirty (30) days following any Change of Control Repurchase Event or, at the option of the
Company, prior to any Change of Control, but after the public announcement of an impending Change of Control, the Company shall mail a notice to each Holder, with a copy to the Trustee, describing the transaction or transactions that constitute or
may constitute the Change of Control Repurchase Event and offering to repurchase the Notes on the payment date specified in the notice, which date shall be no earlier than thirty (30) days and no later than sixty (60) days from the date
such notice is mailed. The notice shall, if mailed prior to the date of consummation of the Change of Control, state that the offer to purchase is conditioned on a Change of Control Repurchase Event occurring on or prior to the payment date
specified in the notice. 

  
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 (c) The Company shall comply with the requirements of Rule
14e-1 under the Exchange Act, and any other securities laws and regulations thereunder, to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a
Change of Control Repurchase Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control Repurchase Event provisions of the Notes, the Company shall comply with the applicable securities laws
and regulations and shall not be deemed to have breached its obligations under the Change of Control Repurchase Event provisions of the Notes or the Indenture by virtue of such conflict. 

(d) On the Change of Control Repurchase Event payment date, the Company shall, to the extent lawful: 

(i) accept for payment all the Notes or portions of the Notes (in minimum denominations of €100,000 and integral
multiples of €1,000 original principal amount above that amount) properly tendered pursuant to its offer; 
 (ii)
deposit with the Paying Agent an amount equal to the aggregate purchase price in respect of all the Notes or portions of the Notes properly tendered; and 

(iii) deliver or cause to be delivered to the Trustee for cancellation the Notes properly accepted, together with an
Officers’ Certificate stating the aggregate principal amount of Notes being repurchased by the Company. 
 (e) The Paying Agent shall
promptly mail to each Holder of Notes properly tendered the purchase price for the Notes, and the Trustee shall promptly authenticate and mail (or, if a Global Note, to be adjusted on the Schedule of Exchanges attached thereto) to each Holder a new
Note equal in principal amount to any unpurchased portion of any Notes surrendered; provided, that each new Note shall be in minimum denominations of €100,000 and integral multiples of €1,000 original principal amount above that amount.

 (f) The Company shall not be required to make a Change of Control Offer upon a Change of Control Repurchase Event if (i) a third
party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for a Change of Control Offer made by the Company and such third party purchases all Notes properly tendered and not withdrawn under its offer or
(ii) the Company has previously or concurrently mailed a redemption notice with respect to all of the outstanding Notes pursuant to Section 3.01(d). 

(g) If holders of not less than 90% in aggregate principal amount of the outstanding Notes validly tender and do not withdraw such Notes in a
Change of Control Offer and the Company, or any third party making such an offer in lieu of the Company pursuant to subsection (f) of this Section 4.01, purchases of all of the Notes validly tendered and not withdrawn by such holders, the
Company or such third party will have the right, upon not less than ten (10) days nor more than sixty (60) days’ prior notice, provided that such notice is given not more than thirty (30) days following such repurchase pursuant
to subsection (b) of this Section 4.01, to redeem all Notes that remain outstanding following such purchase on a date specified in such notice (the “Second Change of Control Payment Date”) and at a price in cash equal to 101% of
the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to, but not including, the Second Change of Control Payment Date. 

  
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 ARTICLE V 

COVENANTS 

Section 5.01 Limitation on Liens. 

(a) The Company shall not, and shall not permit any Restricted Subsidiary to, issue, assume or guarantee any Indebtedness secured by any
Mortgage upon any Principal Property of the Company or any Restricted Subsidiary without equally and ratably securing the Notes (and, if the Company so determines, any other Indebtedness ranking equally with the Notes) with such Indebtedness;
provided, however, that the foregoing restrictions shall not prevent the Company or any Restricted Subsidiary from issuing, assuming or guaranteeing any Indebtedness secured by a Permitted Mortgage. 

(b) Notwithstanding the provisions of subsection (a) of this Section 5.01, the Company or any Restricted Subsidiary may, in
addition to Mortgages permitted by subsection (a) of this Section 5.01 and without equally and ratably securing the Notes, create or assume and renew, extend or replace Mortgages which would otherwise be subject to such subsection (a),
provided that at the time of such creation, assumption, renewal, extension or replacement, and after giving effect thereto, Exempted Debt does not exceed 15% of Consolidated Net Tangible Assets. 

Section 5.02 Limitations on Sale and Leaseback Transactions. 

(a) The Company shall not, and shall not permit any Restricted Subsidiary to, enter into any Sale and Leaseback Transaction without equally
and ratably securing the Notes (and, if the Company so determines, any other Indebtedness ranking equally with the Notes) unless: 

(i) within 180 days after the receipt of the proceeds of such sale or transfer, the Company or any Restricted Subsidiary
applies an amount equal to the greater of the net proceeds of such sale or transfer or the fair value of such Principal Property at the time of such sale or transfer to any (or a combination) of (1) the prepayment or retirement (other than any
mandatory prepayment or retirement) of Senior Funded Debt of the Company or (2) the purchase, construction, development, expansion or improvement of other comparable property, subject in each case to credits for voluntary retirements of Senior
Funded Debt of the Company; or 
 (ii) the Company or such Restricted Subsidiary would be entitled, at the effective date of
such sale or transfer, to incur Indebtedness secured by a Mortgage on such Principal Property, in an amount at least equal to the Attributable Debt in respect of the Sale and Leaseback Transaction, without equally and ratably securing the Notes
pursuant to the provisions of Section 5.01 above. 

  
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 The foregoing restriction shall not apply to any Sale and Leaseback Transaction (w) for
a term of not more than three years including renewals, (x) with respect to a Principal Property if a binding commitment is entered into with respect to such Sale and Leaseback Transaction within three years after the later of
(1) November 30, 2018 or (2) the date when the applicable Principal Property was acquired, (y) with respect to a Principal Property if a binding commitment with respect thereto is entered into within 180 days after the later of
the date such property was acquired and, if applicable, the date such property was first placed in operation, or (z) between the Company and any Restricted Subsidiary or between Restricted Subsidiaries. 

(b) Notwithstanding the provisions of subsection (a) of this Section 5.02, the Company or any Restricted Subsidiary may, in
addition to Sale and Leaseback Transactions permitted by subsection (a) of this Section 5.02 and without equally and ratably securing the Notes, create or assume and renew, extend or replace Mortgages, or enter into any Sale and Leaseback
Transaction without any obligation to retire any Senior Funded Debt of the Company or a Restricted Subsidiary, provided that, at the time of such creation, assumption, renewal, extension or replacement of a Mortgage or at the time of entering into
such Sale and Leaseback Transaction, and after giving effect thereto, Exempted Debt does not exceed 15% of Consolidated Net Tangible Assets. 

ARTICLE VI 

MISCELLANEOUS PROVISIONS 

Section 6.01 Ratification of Base Indenture. This Sixteenth Supplemental Indenture is executed and shall be construed as an
indenture supplemental to the Base Indenture, and as supplemented and modified hereby, the Base Indenture is in all respects ratified and confirmed, and the Base Indenture and this Sixteenth Supplemental Indenture shall be read, taken and construed
as one and the same instrument. 
 Section 6.02 Conflict with Trust Indenture Act. If any provision hereof limits, qualifies or
conflicts with another provision hereof, or with a provision of the Base Indenture, which is required to be included in this Sixteenth Supplemental Indenture, or in the Base Indenture, respectively, by any of the provisions of the Trust Indenture
Act, such required provision shall control to the extent it is applicable. 
 Section 6.03 Effect of Headings. The Article and
Section headings herein are for convenience only and shall not affect the construction hereof. 
 Section 6.04 Successors and
Assigns. All covenants and agreements in this Sixteenth Supplemental Indenture by the Company shall bind its successors and assigns, whether so expressed or not. 

Section 6.05 Separability Clause. In case any one or more of the provisions contained in this Sixteenth Supplemental Indenture or
in the Notes shall for any reason be held to be invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

  
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 Section 6.06 Governing Law. THIS SIXTEENTH SUPPLEMENTAL INDENTURE AND THE NOTES
SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO ITS PRINCIPLES OF CONFLICTS OF LAWS (OTHER THAN SECTION 5-1401 OF THE GENERAL OBLIGATIONS
LAW OF THE STATE OF NEW YORK), EXCEPT TO THE EXTENT THAT THE TRUST INDENTURE ACT IS APPLICABLE, IN WHICH CASE THE TRUST INDENTURE ACT WILL GOVERN. 

Section 6.07 Counterparts. This Sixteenth Supplemental Indenture may be executed in any number of counterparts, and each of such
counterparts shall for all purposes be deemed to be an original, but all such counterparts shall together constitute one and the same instrument. 

[Signature page follows] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Sixteenth Supplemental Indenture to
be duly executed, all as of the day and year first above written. 
  

			
	STRYKER CORPORATION
		
	By:	 	/s/ Jeanne M. Blondia
		 	Name: Jeanne M. Blondia
		 	Title: Vice President, Finance and Treasurer


  

			
	
	U.S. BANK NATIONAL ASSOCIATION
		
	By:	 	/s/ Richard Prokosch
		 	Name: Richard Prokosch
		 	Title: Vice President



  
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 EXHIBIT A 

Form of Face of 2027 Note 
 THIS
SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND CLEARSTREAM BANKING,
S.A. (“CLEARSTREAM” AND, TOGETHER WITH EUROCLEAR, “EUROCLEAR/CLEARSTREAM”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF ELAVON FINANCIAL
SERVICES DAC OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR/CLEARSTREAM (AND ANY PAYMENT IS MADE TO ELAVON FINANCIAL SERVICES DAC OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF
EUROCLEAR/CLEARSTREAM), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, ELAVON FINANCIAL SERVICES DAC, HAS AN INTEREST HEREIN. 

STRYKER CORPORATION 
 2.125% Notes
due 2027 
 No. 

	
	€
	CUSIP NO. 863667AT8
	ISIN NO. XS1914502304
	COMMON CODE 191450230


 Stryker Corporation, a Michigan corporation (herein called the “Company”, which term includes
any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Elavon Financial Services DAC, as common depositary for Euroclear Bank, SA/NV (“Euroclear”) and Clearstream Banking, S.A.
(“Clearstream”), or registered assigns, the principal sum of            Euros on November 30, 2027 and to pay interest thereon from November 30, 2018 or from the most
recent Interest Payment Date to which interest has been paid or duly provided for, annually on November 30 of each year, commencing November 30, 2019, at the rate of 2.125% per annum, until the principal hereof is paid or made available
for payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security is registered at the close of business on the Regular
Record Date for such interest, which 

  
 A-1 













 
shall be the business day (for this purpose, a day on which Clearstream and Euroclear are open for business) immediately preceding such Interest Payment Date. Any such interest not so punctually
paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security is registered at the close of business on a Special Record Date for the payment
of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent
with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and any such interest on this Security will be made at the office or agency of the Company
maintained for that purpose in the City of New York, State of New York or at the office or agency of the Paying Agent maintained for such purposes in the city of London, initially 125 Old Broad Street, Fifth Floor, London EC2N 1AR; provided,
however, that at the option of the Company payment of interest may be made by (i) check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or (ii) wire transfer in immediately
available funds to the place and account designated in writing by the Person entitled to such payment as specified in the Security Register; and provided further, that if this Security is a Global Note, payment may be made pursuant to the Applicable
Procedures of the Depositary or its nominee as permitted in the Indenture. 
 All payments of interest, premium, if any, and principal,
including payments made upon any redemption or repurchase of this Note, will be made in Euro; provided that if the Euro is unavailable to the Company due to the imposition of exchange controls or other circumstances beyond the Company’s control
or if the Euro is no longer being used by the then member states of the European Monetary Union that have adopted the Euro as their currency or for the settlement of transactions by public institutions of or within the international banking
community, then all payments in respect of the Notes will be made in U.S. dollars until the Euro is again available to the Company or so used. In such circumstances, the amount payable on any date in Euro will be converted into U.S. dollars at the
rate mandated by the Board of Governors of the Federal Reserve System as of the close of business on the second business day prior to the relevant payment date or, if the Board of Governors of the Federal Reserve System has not announced a rate of
conversion, on the basis of the most recent U.S. dollar/Euro exchange rate published in The Wall Street Journal on or prior to the second business day prior to the relevant payment date or, in the event The Wall Street Journal has not published such
exchange rate, the rate will be determined in the Company’s sole discretion on the basis of the most recently available market exchange rate for the Euro. Any payment in respect of this Security so made in U.S. dollars will not constitute an
Event of Default (as defined in the Indenture). Neither the Trustee nor the Paying Agent shall have any responsibility for any calculation or conversion in connection with the foregoing. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 

  
 A-2 













 Unless the certificate of authentication hereof has been executed by the Trustee referred to
on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-3 













 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

			
	 STRYKER
CORPORATION



 
			
		
	 By: 
	 	 
		 	 Name:

		 	 Title:



 
			
	
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 CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

			
	U.S. BANK NATIONAL ASSOCIATION
	As Trustee
		
	By:	 	 
		 	Authorized Signatory
		
		 	Dated:



  
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 Form of Reverse of 2027 Note 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 15, 2010 (the “Base Indenture”), as supplemented by the Sixteenth Supplemental Indenture, dated as of November 30, 2018 (the “Supplemental Indenture”
and, together with the Base Indenture, the “Indenture”), between the Company and U.S. Bank National Association, a nationally chartered banking association, as Trustee (herein called the “Trustee”, which term includes any
successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and
of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to €750,000,000, provided that the Company
may, without the consent of any Holder, at any time and from time to time increase the initial principal amount. 
 The Securities of this
series are subject to redemption as provided in Sections 3.01 and 3.02 of the Supplemental Indenture and Article XI of the Base Indenture. 

This Security will not be subject to any sinking fund. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and
Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 
 If an
Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations
of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount of the Securities at the
time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all
Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is
made upon this Security. 
 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the
right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of
Default with respect to 

  
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the Securities of this series, the Holders of not less than 25% in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to
institute proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time
Outstanding a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the
Holder of this Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in minimum denominations of €100,000 and integral
multiples of €1,000 above that amount. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like
tenor of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made for any
such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

THE SECURITIES OF THIS SERIES SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF NEW YORK WITHOUT REGARD
TO ITS PRINCIPLES OF CONFLICTS OF LAWS (OTHER THAN SECTION 5-1401 OF THE GENERAL OBLIGATIONS LAW OF THE STATE OF NEW YORK), EXCEPT TO THE EXTENT THAT THE TRUST INDENTURE ACT IS APPLICABLE, IN WHICH CASE THE
TRUST INDENTURE ACT WILL GOVERN. 
 All terms used in this Security which are defined in the Indenture shall have the meanings assigned to
them in the Indenture. 

  
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