Exhibit 31.1

# Certification of Chief
Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act and Rule 13a-14(a)or
15d-14(a) under the Securities Exchange Act of 1934

I,
Duane J. Roth, certify that:

1.                 I
have reviewed this Quarterly Report on Form 10-QSB of Alliance Pharmaceutical
          Corp.;

2.                 Based
on my knowledge, this report does not contain any untrue statement of a
          material fact or omit to state a material fact necessary to make the statements
          made, in light of the circumstances under which such statements were made, not
          misleading with respect to the period covered by this report;

3.                 Based
on my knowledge, the financial statements, and other financial information
          included in this report, fairly present in all material respects the financial
          condition, results of operations and cash flows of the registrant as of, and
          for, the periods presented in this report;

4.                 I
am responsible for establishing and maintaining disclosure controls and
          procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e) for the
          registrant and have:

| | a.                      Designed
such disclosure controls and procedures, or caused such disclosure
               controls and procedures to be designed under my supervision, to ensure
that                material information relating to the registrant, including its
consolidated                subsidiaries, is made known to me by others within those
entities, particularly                during the period in which this report is being
prepared;
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| | b.                      Evaluated
the effectiveness of the registrants disclosure controls and
               procedures and presented in this report my conclusions about the
effectiveness                of the disclosure controls and procedures, as of the end of
the period covered                by this report based on such evaluation; and
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| | c.                      Disclosed
in this report any change in the registrants internal control                over
financial reporting that occurred during the registrants most recent
               fiscal quarter (the registrants fourth fiscal quarter in the case of
an                annual report) that has materially affected, or is reasonably likely to
               materially affect, the registrants internal control over financial
               reporting; and
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5.                 I
have disclosed, based on my most recent evaluation of internal control over
          financial reporting, to the registrants auditors and the audit committee
          of the registrants board of directors (or persons performing the
          equivalent functions):

| | a.                      All
significant deficiencies and material weaknesses in the design or operation
               of internal control over financial reporting which are reasonably likely
to                adversely affect the registrants ability to record, process,
summarize and                report financial information; and
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| | b.                      Any
fraud, whether or not material, that involves management or other employees
               who have a significant role in the registrants internal control over
               financial reporting.
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|Date:  February 19, 2004 | /s/ DUANE J. ROTH      
|------------------------ | -----------------------
|                         | Duane J. Roth          
|                         | Chief Executive Officer