Exhibit 31.1

# CERTIFICATION OF
CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT AND RULE
13A-14(A) OR 15D-14(A) UNDER THE
SECURITIES EXCHANGE ACT OF 1934

I,
Duane J. Roth, certify that:

1.     I
have reviewed this Quarterly Report on Form 10-QSB of Alliance Pharmaceutical
          Corp. for the quarter ended March 31, 2004.

2.     Based
on my knowledge, this report does not contain any untrue statement of a
          material fact or omit to state a material fact necessary to make the statements
          made, in light of the circumstances under which such statements were made, not
          misleading with respect to the period covered by this report.

3.     Based
on my knowledge, the financial statements, and other financial information
          included in this report, fairly present in all material respects the financial
          condition, results of operations and cash flows of the small business issuer as
          of, and for, the periods presented in this report.

4.     The
small business issuers other certifying officer(s) and I are           responsible
for establishing and maintaining disclosure controls and procedures           (as defined
in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the small           business issuer
and have:

| | a.     Designed
such disclosure controls and procedures, or caused such disclosure           controls and
procedures to be designed under our supervision, to ensure that           material
information relating to the small business issuer, including its           consolidated
subsidiaries, is made known to us by others within those entities,           particularly
during the period in which this report is being prepared;
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | b.     Evaluated
the effectiveness of the small business issuers disclosure           controls and
procedures and presented in this report our conclusions about the           effectiveness
of the disclosure controls and procedures, as of the end of the           period covered
by this report based on such evaluation; and
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | c.     Disclosed
in this report any change in the small business issuers internal           control
over financial reporting that occurred during the period covered by the
          Quarterly Report that has materially affected, or is reasonably likely to
          materially affect, the small business issuers internal control over
          financial reporting.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

5.     
    The small business issuers other certifying officer(s) and
I have disclosed, based on our most recent evaluation of internal control over financial
reporting, to the small business issuers auditors and the audit committee of the
small business issuers board of directors (or persons performing the equivalent
functions):

| | a.     All
significant deficiencies and material weaknesses in the design or operation           of
internal control over financial reporting which are reasonably likely to
          adversely affect the small business issuers ability to record, process,
          summarize and report financial information; and
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | b.     Any
fraud, whether or not material, that involves management or other employees           who
have a significant role in the small business issuers internal control
          over financial reporting.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|                    |    
|------------------- | ---
|Date:  May 17, 2004 | By:
|                    |