Page 2 of 12

(oxyethylene) polymers where the alkyl chain contains a minimum of six carbons (also 

referred to herein as Alkyl Alcohol Alkoxylates or AAA)

C>14, ethoxylated (CAS Reg. No. 251553-55-6) in pesticide formulations acts as a dispersant, an 

emulsifier, a solvent or as a surfactant. The registrant requests the exemption with no limitation 

as to the concentration of the material in final pesticide formulations.

The purpose of this document is to assess, as required under the Federal Food Drug and Cosmetic 

Act (FFDCA), the risk of the use of an additional CAS Reg. No. as an inert ingredient in pesticide 

products and is based on previous assessments for AAAs along with a rationale provided by the 

petitioner as to why the additional CAS Reg. No. can be considered safe under the existing 

tolerance exemption descriptors for AAA. The petition contends that alcohols C>14, ethoxylated 

(CAS Reg. No. 251553-55-6) is structurally similar to the group Alkyl Alcohol Alkoxylates 

(AAA) previously reviewed in the Agency’s risk assessment (Davis et al. 1993). Specifically, the 

contention is that CAS Reg. No. 251553-55-6 meets the chemical identity ɑ-alkyl-ω-hydroxypoly 

(oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a minimum of 

six carbons.

According to the petition, the degree of alkoxylation for the petitioned substance can vary in 

number average molecular weight from a range of approximately 591 to 5,513. In cases where the 

minimum number average molecular weight is 1,100 or more, the petition’s basis for support for 

establishment of an exemption from the requirement of tolerance under 40 CFR §180.960 is that 

AAAs with high molecular weights meet the criteria for a low-risk polymer as defined under 40 

CFR § 723.250. Further, for the remaining AAAs, those with lower molecular weights between 

591 and 1,100, the petition seeks to establish tolerance exemptions for all AAAs under 40 CFR § 

180.910, 180.930 and 180.940(a). 

The petition suggests that for the higher molecular weight polymers that would fall under 180.960, 

there are no risk concerns since molecules of such high molecular weight are not likely to be 

absorbed significantly by any route of exposure that is reasonably foreseeable. Thus it is posited 

that there is low concern for potential hazards to the general population or for infants and children.

For the lower molecular weight AAA’s that would fall under 40 CFR § 180.910, 180.930 and 

180.940(a), the registrant is relying upon the Agency’s previous review of the AAAs as noted 

earlier. The petitioner has been granted permission by the data owner(s) to cite MRIDs 47067001, 

47676801, 47050602, 47676803, and 47676802 in support of the proposed request for the 

exemption from the requirements of a tolerance. 

The Agency has reviewed the petitioner’s claim that the addition of the requested CAS Reg. No. is 

acceptable under the current tolerance exemption descriptors for AAA. . The CITAB has 

confirmed that the requested CAS Reg. No. is appropriately added to the currently approved 

descriptors and that no further review is required. The requested CAS Reg. No. does consist of 

compounds that meets the chemical identity ɑ-alkyl-ω-hydroxypoly (oxypropylene) and/or poly 

(oxyethylene) polymers where the alkyl chain contains a minimum of six carbons.
Page 3 of 12

The Agency has determined that the proposed addition of the requested CAS Reg. No. is

adequately supported by the existing data and assessment and that no additional data or

review is required. Inclusion of the additional chemicals described above in the risk

assessments for ɑ-alkyl-ω-hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers would 

in no way alter the prior risk assessments given the generic findings on toxicity and the worst case 

exposure assumptions used in those risk assessments. Accordingly, based on the findings in the 

earlier rules, EPA has determined that there is a reasonable certainty that no harm to any 

population subgroup, including infants and children, will result from aggregate exposure to ɑalkyl-ω-hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers by including the 

additional chemical described above, under reasonably foreseeable circumstances.

Therefore, the amendment of an exemption from the requirements of a tolerance under 40 CFR 

180. 910, 180.930, 180.940(a) and 180.960 is approved on the bases where the minimum number 

average molecular weight is 1,100 or more, qualifies for exemption under 40 CFR §180.960 and 

that the remaining AAAs, those with lower molecular weights between 591 and 1,100, would 

qualify under 40 CFR § 180.910, 180.930 and 180.940(a). 

Based upon the information summarized above from the Agency’s previous assessments, the 

Agency approves of the request to amend an existing tolerance exemption descriptor for ɑ-alkyl-ωhydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers by adding one CAS Reg. No. 

(251553-55-6 for alcohols, C>14, ethoxylated) to a grouping of closely related substances with 

associated CAS Reg. Nos. rather than to a single chemical entity. 

Therefore the regulatory text associated with the tolerance exemption for α-alkyl-ω-hydroxypoly 

(oxypropylene) and/or poly (oxyethylene) polymers under 40 CFR 180.910 and 930 will be 

revised to read as follows:

Inert ingredients Limits Uses

α-alkyl-ω-hydroxypoly (oxypropylene) and/or 

poly (oxyethylene) polymers where the alkyl 

chain contains a minimum of six carbons 

(CAS Reg. Nos.: 9002-92-0; 9004-95-9; 9004-

98-2; 9005-00-9; 9035-85-2; 9038-29-3; 9038-

43-1; 9040-05-5; 9043-30-5; 9087-53-0; 

25190-05-0; 24938-91-8; 25231-21-4; 251553-

55-6; 26183-52-8; 26468-86-0; 26636-39-5; 

27252-75-1; 27306-79-2; 31726-34-8; 34398-

01-1; 34398-05-5; 37251-67-5; 37311-00-5; 

37311-01-6; 37311-02-7; 37311-04-9; 39587-

22-9; 50861-66-0; 52232-09-4; 52292-17-8; 

52609-19-5; 57679-21-7; 59112-62-8; 60828-

78-6; 61702-78-1; 61725-89-1; 61791-13-7; 

61791-20-6; 61791-28-4; 61804-34-0; 61827-

42-7; 61827-84-7; 62648-50-4; 63303-01-5; 

63658-45-7; 63793-60-2; 64366-70-7; 64415-

Surfactants, related adjuvants 

of surfactants
Page 4 of 12

24-3; 64415-25-4; 64425-86-1; 65104-72-5; 

65150-81-4; 66455-14-9: 66455-15-0; 67254-

71-1; 67763-08-0; 68002-96-0; 68002-97-1; 

68131-39-5; 68131-40-8; 68154-96-1; 68154-

97-2; 68154-98-3; 68155-01-1; 68213-23-0; 

68213-24-1; 68238-81-3; 68238-82-4; 68409-

58-5; 68409-59-6; 68439-30-5; 68439-45-2; 

68439-46-3; 68439-48-5; 68439-49-6; 68439-

50-9; 68439-51-0; 68439-53-2; 68439-54-3; 

68458-88-8; 68526-94-3; 68526-95-4; 68551-

12-2; 68551-13-3; 68551-14-4; 68603-20-3; 

68603-25-8; 68920-66-1; 68920-69-4; 68937-

66-6; 68951-67-7; 68954-94-9; 68987-81-5; 

68991-48-0; 69011-36-5; 69013-18-9; 69013-

19-0; 69227-20-9; 69227-21-0; 69227-22-1; 

69364-63-2; 70750-27-5; 70879-83-3; 70955-

07-6; 71011-10-4; 71060-57-6; 71243-46-4; 

72066-65-0; 72108-90-8; 72484-69-6; 72854-

13-8; 72905-87-4; 73018-31-2; 73049-34-0; 

74432-13-6; 74499-34-6; 78330-19-5; 78330-

20-8; 78330-21-9; 78330-23-1; 79771-03-2; 

84133-50-6; 85422-93-1; 97043-91-9; 97953-

22-5; 102782-43-4; 103331-86-8; 103657-84-

7; 103657-85-8; 103818-93-5; 103819-03-0; 

106232-83-1; 111905-54-5; 116810-31-2; 

116810-32-3; 116810-33-4; 120313-48-6; 

120944-68-5; 121617-09-2; 126646-02-4; 

126950-62-7; 127036-24-2; 139626-71-4; 

152231-44-2; 154518-36-2; 157627-86-6; 

157627-88-8; 157707-41-0; 157707-43-2; 

159653-49-3; 160875-66-1; 160901-20-2; 

160901-09-7; 160901-19-9; 161025-21-4; 

161025-22-5; 166736-08-9; 169107-21-5; 

172588-43-1; 176022-76-7; 196823-11-7; 

287935-46-0; 288260-45-7; 303176-75-2; 

954108-36-2)

The regulatory text associated with the tolerance exemption for α-alkyl-ω-hydroxypoly 

(oxypropylene) and/or poly (oxyethylene) polymers under 40 CFR 180.940(a) will be revised to 

read as follows:

Pesticide Chemical CAS Reg. No Limits

α-alkyl-ω-hydroxypoly (oxypropylene) and/or 

poly (oxyethylene) polymers where the alkyl 

9002-92-0; 9004-

95-9; 9004-98-2; 
Page 5 of 12

chain contains a minimum of six carbons (CAS 

Reg. No 251553-55-6)

9005-00-9; 9035-

85-2; 9038-29-3; 

9038-43-1; 9040-

05-5; 9043-30-5; 

9087-53-0; 

25190-05-0; 

24938-91-8; 

25231-21-4; 

251553-55-6; 

26183-52-8; 

26468-86-0; 

26636-39-5; 

27252-75-1; 

27306-79-2; 

31726-34-8; 

34398-01-1; 

34398-05-5; 

37251-67-5; 

37311-00-5; 

37311-01-6; 

37311-02-7; 

37311-04-9; 

39587-22-9; 

50861-66-0; 

52232-09-4; 

52292-17-8; 

52609-19-5; 

57679-21-7; 

59112-62-8; 

60828-78-6; 

61702-78-1; 

61725-89-1; 

61791-13-7; 

61791-20-6; 

61791-28-4; 

61804-34-0; 

61827-42-7; 

61827-84-7; 

62648-50-4; 

63303-01-5; 

63658-45-7; 

63793-60-2; 

64366-70-7; 

64415-24-3; 

64415-25-4; 

64425-86-1; 
Page 

6 of 12

65104-72-5; 

65150-81-4; 

66455-14-9: 

66455-15-0; 

67254-71-1; 

67763-08-0; 

68002-96-0; 

68002-97-1;

68131-39-5; 

68131-40-8; 

68154-96-1; 

68154-97-2; 

68154-98-3; 

68155-01-1; 

68213-23-0; 

68213-24-1; 

68238-81-3; 

68238-82-4; 

68409-58-5; 

68409-59-6; 

68439-30-5; 

68439-45-2; 

68439-46-3; 

68439-48-5; 

68439-49-6; 

68439-50-9; 

68439-51-0; 

68439-53-2; 

68439-54-3; 

68458-88-8; 

68526-94-3; 

68526-95-4; 

68551-12-2; 

68551-13-3; 

68551-14-4; 

68603-20-3; 

68603-25-8; 

68920-66-1; 

68920-69-4; 

68937-66-6; 

68951-67-7; 

68954-94-9; 

68987-81-5; 

68991-48-0; 

69011-36-5; 

69013-18-9; 
Page 

7 of 12

69013-19-0; 

69227-20-9; 

69227-21-0; 

69227-22-1; 

69364-63-2; 

70750-27-5; 

70879-83-3; 

70955-07-6; 

71011-10-4; 

71060-57-6; 

71243-46-4; 

72066-65-0; 

72108-90-8; 

72484-69-6; 

72854-13-8; 

72905-87-4; 

73018-31-2; 

73049-34-0; 

74432-13-6; 

74499-34-6; 

78330-19-5; 

78330-20-8; 

78330-21-9; 

78330-23-1; 

79771-03-2; 

84133-50-6;

85422-93-1; 

97043-91-9; 

97953-22-5; 

102782-43-4; 

103331-86-8; 

103657-84-7; 

103657-85-8; 

103818-93-5; 

103819-03-0; 

106232-83-1; 

111905-54-5; 

116810-31-2; 

116810-32-3; 

116810-33-4; 

120313-48-6; 

120944-68-5; 

121617-09-2; 

126646-02-4; 

126950-62-7; 

127036-24-2; 
Page 8 of 12

139626-71-4; 

152231-44-2; 

154518-36-2; 

157627-86-6; 

157627-88-8; 

157707-41-0; 

157707-43-2; 

159653-49-3; 

160875-66-1; 

160901-20-2; 

160901-09-7; 

160901-19-9; 

161025-21-4; 

161025-22-5; 

166736-08-9; 

169107-21-5; 

172588-43-1; 

176022-76-7; 

196823-11-7; 

287935-46-0; 

288260-45-7; 

303176-75-2; 

954108-36-2

The regulatory text associated with the tolerance exemption for α-alkyl-ω-hydroxypoly 

(oxypropylene) and/or poly (oxyethylene) polymers under 40 CFR 180.960 will be revised to read 

as follows:

Polymer CAS No.

α-alkyl-ω-hydroxypoly (oxypropylene) and/or poly 

(oxyethylene) polymers where the alkyl chain contains a 

minimum of six carbons and a minimum number average 

molecular weight (in amu) 1,100

9002-92-0; 9004-95-9; 

9004-98-2; 9005-00-9; 

9035-85-2; 9038-29-3; 

9038-43-1; 9040-05-5; 

9043-30-5; 9087-53-0; 

25190-05-0; 24938-91-8; 

25231-21-4; 251553-55-

6; 26183-52-8; 26468-

86-0; 26636-39-5; 

27252-75-1; 27306-79-2; 

31726-34-8; 34398-01-1; 

34398-05-5; 37251-67-5; 

37311-00-5; 37311-01-6; 

37311-02-7; 37311-04-9; 
Page 9 of 12

39587-22-9; 50861-66-0; 

52232-09-4; 52292-17-8; 

52609-19-5; 57679-21-7; 

59112-62-8; 60828-78-6; 

61702-78-1; 61725-89-1; 

61791-13-7; 61791-20-6; 

61791-28-4; 61804-34-0; 

61827-42-7; 61827-84-7; 

62648-50-4; 63303-01-5; 

63658-45-7; 63793-60-2; 

64366-70-7; 64415-24-3; 

64415-25-4; 64425-86-1; 

65104-72-5; 65150-81-4; 

66455-14-9: 66455-15-0; 

67254-71-1; 67763-08-0; 

68002-96-0; 68002-97-1; 

68131-39-5; 68131-40-8; 

68154-96-1; 68154-97-2; 

68154-98-3; 68155-01-1; 

68213-23-0; 68213-24-1; 

68238-81-3; 68238-82-4; 

68409-58-5; 68409-59-6; 

68439-30-5; 68439-45-2; 

68439-46-3; 68439-48-5; 

68439-49-6; 68439-50-9; 

68439-51-0; 68439-53-2; 

68439-54-3; 68458-88-8; 

68526-94-3; 68526-95-4; 

68551-12-2; 68551-13-3; 

68551-14-4; 68603-20-3; 

68603-25-8; 68920-66-1; 

68920-69-4; 68937-66-6; 

68951-67-7; 68954-94-9; 

68987-81-5; 68991-48-0; 

69011-36-5; 69013-18-9; 

69013-19-0; 69227-20-9; 

69227-21-0; 69227-22-1; 

69364-63-2; 70750-27-5; 

70879-83-3; 70955-07-6; 

71011-10-4; 71060-57-6; 

71243-46-4; 72066-65-0; 

72108-90-8; 72484-69-6; 

72854-13-8; 72905-87-4; 

73018-31-2; 73049-34-0; 

74432-13-6; 74499-34-6; 

78330-19-5; 78330-20-8; 
Page 10 of 12

78330-21-9; 78330-23-1; 

79771-03-2; 84133-50-6; 

85422-93-1; 97043-91-9; 

97953-22-5; 102782-43-

4; 103331-86-8; 103657-

84-7; 103657-85-8; 

103818-93-5; 103819-

03-0; 106232-83-1; 

111905-54-5; 116810-

31-2; 116810-32-3; 

116810-33-4; 120313-

48-6; 120944-68-5; 

121617-09-2; 126646-

02-4; 126950-62-7; 

127036-24-2; 139626-

71-4; 152231-44-2; 

154518-36-2; 157627-

86-6; 157627-88-8; 

157707-41-0; 157707-

43-2; 159653-49-3; 

160875-66-1; 160901-

20-2; 160901-09-7; 

160901-19-9; 161025-

21-4; 161025-22-5; 

166736-08-9; 169107-

21-5; 172588-43-1; 

176022-76-7; 196823-

11-7; 287935-46-0; 

288260-45-7; 303176-

75-2; 954108-36-2
Page 11 of 12

Reference

Davis, D., B-H. Chin, A. LaMay, M. Lloyd, C. Olinger, S. Piper. 2009. Alkyl Alcohol Alkoxylate 

Phosphate and Sulfate Derivatives (AAAPDs and AAASDs – JITF CST 2 Inert Ingredients). 

Human Health Assessment to Support Proposed Exemption from the Requirement of a Tolerance 

When Used as Inert Ingredients in Pesticide Formulations. CASRN 9046-01-9. PC Code 911339. 

Unpublished Memorandum 8 June 2009 to K. Leifer U.S. EPA.

RDI: PV Shah, K. Leifer

M.I.Dow:S7958:PY1:(703)305-5533:IIAB:7505P
Page 12 of 12