UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

DATE: 

SUBJECT: 

23-JAN-20 14 

Saflufenacil. Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for Tolerances for Residues in/on Fish, Crayfish, 

and Imported Sugarcane. 

PC Code: 118203 DP Barcodes: D405747 & D41 2991 

Decision Nos.: 467996 & 473447 Registration No: 7969-278 

Petition Nos.: 2E8065 & 2F8129 Regulatory Action: Sec. 3 Registration and 

Tolerance With No U.S. Registration 

Risk Assessment Type: Dietary Case No.: 7277 

TXRNo.: NA CAS No.: 372137-35-4 

MRID No.: NA 40 CFR: §180.649 

FROM: 

THROUGH: 

George F. Kramer, Ph.D., Senior Chemist ,e~~~~~~.....,~-­

Risk Assessment Branch 1 (RABl)/Health Effects Division (HED; 7509P) 

Julie L. Van Alstine, M~H, nvir<? ~~Jliea!th~~ 

Thurston Morton, Chemist /~r ?~ 

Dietary Exposure Science Advisory Council (DESAC) 

HED (7509P) 

and 

Cha

RABI

rles 

, H

w

ED(7509

. Smith III

P) 

, Branch ChieC - r 

~ 

~ 

e:rTO: George F. Kramer, Ph.D., Risk Assessor 

RAB 1/HED (7509P) 

and 

Kathryn Montague/Bethany Benbow, PM Team 23 

Registration Division (RD) (7505P) 

Executive Summary 

Acute and chronic dietary-exposure and risk assessments were conducted using the Dietary 

Exposure Evaluation Model -Food Consumption Intake Database (DEEM-FCID, ver. 3.16) 

which incorporates consumption data from United States Department of Agriculture (USDA) 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA; 2003-2008). These analyses were performed to support tolerance petitions 

Page 1 of 18 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747 

for residues in/on fish, crayfish, and sugarcane. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 

The unrefined acute analysis assumed 100% crop treated (CT), DEEM 7.81 default concentration 

factors, and tolerance-level residues for all commodities [except for cottonseed; sunflower 

subgroup 208; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); 

and rapeseed subgroup 20A - see Section II for more details). The drinking water estimate from 

the proposed U.S. use was incorporated directly into the dietary assessment using the 

concentration for surface water generated by Tier I Rice modeling. The acute dietary risk 

estimates (food + water) at the 95th percentile are <1% of the acute population-adjusted dose 

(aPAD) for the general U.S. population and <1% of the aPAD for the most highly exposed 

population subgroup (all infants (<1 year old)), and are thus below HED's level of concern 

(<100% aPAD). 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization 

The unrefined chronic analysis assumed 100% CT, DEEM 7.81 default concentration factors, 

and tolerance-level residues for all commodities [except for cottonseed; sunflower subgroup 

208; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); and 

rapeseed subgroup 20A - see Section II for more details]. The drinking water estimate from the 

proposed U.S. use was incorporated directly into the dietary assessment using the concentration 

for surface water generated by Tier I Rice modeling. The chronic dietary risk estimates (food + 

water) 6.7% of the chronic population-adjusted dose (cPAD) for the general U.S. population and 

18% of the cP AD for the most highly exposed population subgroup (all infants ( <1 year old)) 

and are thus below HED's level of concern (<100% cPAD). 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization 

Saflufenacil is classified as "not likely carcinogenic to humans. " Therefore, cancer risk is not a 

concern for this chemical. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to point of departure (POD, 

NOAEL, LOAEL, i.e.) divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds l 00% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link: 

http://www.cpa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/606l.pdf; or see SOP 99.6 (20-AUG1999). 

Page 2 of 18 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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The most recent dietary exposure risk assessment for saflufenacil was conducted by G. Kramer 

(Memo, 04-AUG-2011, D390923).

II. Residue Information

Saflufenacil Proposed and Registered Uses:

Saflufenacil is currently registered for use on legume vegetables (crop group 06), the foliage of 

legume vegetables (crop group 07), cereal grains (crop group 15), forage, fodder, and straw of 

cereal grains (crop group 16), cottonseed (subgroup 20C), rapeseed (subgroup 20A), and 

sunflower (subgroup 20B). BASF has submitted a tolerance petition for residues in/on imported 

sugarcane (PP#2E8065). In addition, BASF has submitted a proposal to allow post-emergence

application of saflufenacil to rice in the U.S. and to permit crayfish and fish to be grown in the 

treated rice fields (PP#2F8129).

Residues of Concern: The nature of the residue in plants, rotational crops, and livestock is 

adequately understood based on acceptable metabolism studies conducted on corn (preplant

application), soybean (preplant and preharvest application), tomato (preplant application), 

rotational crops, lactating goats, and laying hens. The HED Residues of Concern 

Knowledgebase Subcommittee (ROCKS) determined that residues of concern for the tolerance 

expression and risk assessment in plants consist of saflufenacil, M800H11, and M800H35; and

that saflufenacil is the only residue of concern in livestock (Memo, B. Daiss, 1/6/09; D359645). 

An additional major metabolite (M800H02) that is not included in the tolerance expression was 

observed in soybean seed following preharvest (harvest aid) application. As the structure of 

M800H02 is closely related to the parent compound and it is the precursor of the regulated 

metabolite M800H11, RAB1 concluded that M800H02 is a residue of concern for riskassessment purposes in crops following post-emergence treatment. 

The petitioner submitted a metabolism study on rice following post-emergence treatment. The 

combined residues of saflufenacil, M800H11, and M800H35 in rice forage were 71-89% of the 

TRR. The only other major metabolite was M800H02, which accounted for 4-16% of the TRR. 

HED thus concludes that current tolerance expression adequately accounts for the residues of 

concern in sugarcane. Additionally, as residues of the parent compound were generally less than 

the limit of quantitation (LOQ) in the field trials, M800H02 does not need to be included as a 

residue of concern for risk-assessment purposes for sugarcane. In rice grain, the combined 

residues of saflufenacil and all metabolites was <10% of the TRR (≤0.01 ppm). HED thus 

concludes that current tolerance expression adequately accounts for the residues of concern in 

rice grain following post-emergence foliar application to rice.

Table 1. Summary of Metabolites and Degradates to be Included in the Risk Assessment.

Matrix Residues Included in Risk 

Assessment

Residues Included in 

Tolerance Expression

Plants

Primary Crops (preplant 

application)

Saflufenacil + M800H11, 

M800H35

Saflufenacil + M800H11, 

M800H35

Primary Crops 

(preharvest application)*

Saflufenacil + M800H11, 

M800H02, M800H35

Rotational Crops Saflufenacil + M800H11, 

M800H35
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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Table 1. Summary of Metabolites and Degradates to be Included in the Risk Assessment.

Matrix Residues Included in Risk 

Assessment

Residues Included in 

Tolerance Expression

Livestock

Ruminants

Saflufenacil Saflufenacil

Poultry

Drinking Water

Saflufenacil + M800H01, 

M800H02, M800H07, M800H08, 

M800H15, M800H22, Product 8

Not Applicable

* Excluding sugarcane and rice.

Established Tolerances: Permanent tolerances for “saflufenacil, including its metabolites and 

degradates, in or on the commodities in the table below. Compliance with the tolerance levels 

specified below is to be determined by measuring only the sum of saflufenacil, 2-chloro-5-[3,6-

dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-

methylethyl)amino]sulfonyl]benzamide, and its metabolites N-[2-chloro-5-(2,6-dioxo-4-

(trifluoromethyl)-3,6-dihydro-1(2H)-pyrimidinyl)-4-fluorobenzoyl]-N'-isopropylsulfamide and 

N-[4-chloro-2-fluoro-5-({[(isopropylamino)sulfonyl]amino}carbonyl)phenyl]urea, calculated as 

the stoichiometric equivalent of saflufenacil” are currently established under 40 CFR 

§180.649(a)(1) for residues on citrus fruit (Crop Group 10), pome fruit (Crop Group 11), stone

fruit (Crop Group 12), grape, tree nuts (Crop Group 14), legume vegetables (crop group 06), the 

foliage of legume vegetables (crop group 07), cereal grains (crop group 15), forage, fodder, and 

straw of cereal grains (crop group 16), cottonseed (subgroup 20C), rapeseed (subgroup 20A),

sunflower (subgroup 20B), coffee, banana, and mango. Additionally, permanent tolerances for 

“saflufenacil, including its metabolites and degradates, in or on the commodities in the table 

below. Compliance with the tolerance levels specified below is to be determined by measuring 

only saflufenacil, 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-

pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide” are currently 

established under 40 CFR §180.649(a)(2) for residues on livestock commodities.

Recommended Tolerances: Based on the residue chemistry data submitted with the current 

petitions, HED recommended for establishment of the following tolerances (G. Kramer, 02-

APR-2013; D405746 and G. Kramer, 23-JAN-2014; D407976):

Table 2. Tolerance Summary for Saflufenacil.

Commodity Recommended Tolerance (ppm)

40 CFR §180.649(a)(1)

Sugarcane, cane 0.05

Sugarcane, molasses 0.08

40 CFR §180.649(a)(2)

Fish-freshwater finfish 0.01

Fish-shellfish, crustacean 0.01

Residue Data used for Acute and Chronic Assessments:

The acute and chronic assessments were based on the assumption of tolerance-level residues for 

all commodities, except for cottonseed; sunflower subgroup 20B; soybean, seed; vegetable, 

legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A. For these 

crops, residues were also based on the recommended tolerances; however, a correction factor 

was applied to the tolerance level to account for the M800H02 metabolite included in the risk 

assessment as a result of preharvest uses. The additional metabolite, M800H02, was observed in 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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the metabolism studies of preharvest-treated soybean seed, comprising 26.3% of the total 

radioactive residues (G. Kramer, 3/24/11; DP# 381129). Since the toxicity of the M800H02 is 

expected to be comparable to the parent compound, it was included in the risk assessment for 

preharvest uses, but not in the tolerance expression. To account for this additional toxicity 

exposure, the recommended tolerance level was multiplied by a correction factor of 1.7X, where 

1.7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression). 

1.7 = (Saflufenacil + M800H11 + M800H02 + M800H35)/(Saflufenacil + M800H11 + M800H35) = 

(26.1% + 10.9% + 26.3% + 0%)/(26.1% + 10.9% + 0%)

Therefore, in the acute and chronic assessments, a residue of 0.34 ppm was used for cottonseed; 

a residue of 1.7 ppm was used for sunflower subgroup 20B; a residue of 0.17 ppm was used for 

soybean, seed; a residue of 0.51 ppm was used for vegetable, legume, subgroup 6C, pea and bean 

(except soybean); and a residue of 0.76 ppm was used for rapeseed subgroup 20A (see Table 3).

Table 3. Corrected Residues Used in the Chronic Assessment.

Crop Group and/or Commodity Tolerance (ppm)2 Corrected Residue Used in Dietary Assessments

1

Cottonseed Subgroup 20C 0.20 0.34

Sunflower Subgroup 20B 1.0 1.7

Soybean, seed 0.10 0.17

Vegetable, Legume, Subgroup 6C, 

pea and bean (except soybean) 0.30 0.51

Rapeseed Subgroup 20A 0.45 0.76

1 Tolerance level residues were corrected to account for the addition of the M800H02 metabolite which was observed in the 

metabolism studies of preharvest-treated soybean seed. The recommended tolerance level was multiplied by a correction factor 

of 1.7X, where 1.7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression).

2 These are HED-recommended tolerances based on Petitions 0F7744 and 0F7766.

Processing Factors: DEEM 7.81 default processing factors were used for all processed 

commodities (where provided).

III. Percent Crop Treated Information

The acute and chronic assessments were based on the assumption of 100% CT for all 

commodities.

IV. Drinking Water Data

The Estimated Drinking Water Concentrations (EDWCs) used in the dietary exposure risk 

assessment were provided by the Environmental Fate and Effects Division (EFED) in a 

memorandum dated 12-AUG-2013 (Memo, M. Ruhman; DP# 413592). Water residues were 

incorporated directly into the DEEM-FCID into the food categories “water, direct, all sources” 

and “water, indirect, all sources.”

Screening EDWCs (Table 4) of saflufenacil were generated with surface water generated by Tier 

I Rice modeling. Modeled application rates represent the maximum use patterns for dry-seeded 

rice: the 1st application at planting, the second application 14 days after planting and flooding at 

45 days after planting. Remaining model input parameters were chosen according to current 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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guidance (USEPA, 2002). EDWCs reflect exposure to saflufenacil and all degradates of concern 

in drinking water (Table 1). 

Table 4. Tiered EDWCs for Proposed Saflufenacil Uses.

Source (Tier: Model)

1-in-10-year Peak Exposure 

(ppb)

1-in-10-year Annual Mean 

Exposure (ppb)

Surface water (Tier I: Rice Model) 133

(used in acute analysis)

120

(used in chronic analysis)

Ground water (Tier II: PRZM GW) 69.2 51.5

V. DEEM-FCID Program and Consumption Information

Saflufenacil acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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VI. Toxicological Information

Table 5. Summary of Toxicological Doses and Endpoints for Saflufenacil for Use in Dietary Human-Health Risk 

Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA SFs

RfD, PAD, 

LOC for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children)

NOAEL = 500 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

Acute RfD =

5.0 mg/kg

aPAD = 5.0 

mg/kg

Acute Neurotoxicity Study.

NOAEL = 500 (M) and 2000 (F) mg/kg/day.

LOAEL was 2000 mg/kg/day (males) based on 

the decreased motor activity representing mild 

and transient systemic toxicity. 

LOAEL was not established for females.

Chronic 

Dietary (All 

Populations)

NOAEL = 4.6 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

Chronic RfD 

= 0.046 

mg/kg/day

cPAD = 0.046 

mg/kg/day

Chronic/Carcinogenicity (mouse).

NOAEL = 4.6 mg/kg bw/d (males) and 18.9 

mg/kg bw/d (females). 

LOAELs = 13.8 mg/kg bw/d (males) and 38.1 

mg/kg bw/day (females) based on decreased 

red blood cells, hemoglobin, and hematocrit 

and porphyria observed in the satellite group.

Cancer (oral, 

dermal, 

inhalation)

Classification: Not carcinogenic based on the lack of tumors in the mouse and rat carcinogenicity 

studies and lack of mutagenicity.

NOAEL = no-observed adverse-effect level. LOAEL = lowest-observed adverse-effect level. UF = uncertainty 

factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity among 

members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population-adjusted 

dose (a = acute, c = chronic). RfD = reference dose. LOC = level of concern.

VII. Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 6 are for the general U.S. 

population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12

years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50-

99 years old. 

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary risk for food and drinking water utilized (<1% of the aPAD for the U.S. 

population. The acute dietary risk for the highest exposed population subgroup, all infants (<1 

year old), is <1% of the aPAD at the 95th percentile.

The chronic dietary risk for food and drinking water utilized 6.7% of the cPAD for the U.S. 

population. The chronic dietary risk for the highest exposed population subgroup, all infants (<1 

year old), is 18% of the cPAD. 

The results of the acute and chronic dietary exposure analyses are reported in Table 6. 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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Table 6. Summary of Dietary (Food and Drinking Water) Exposure Risk for Saflufenacil.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary

Dietary Exposure 

(mg/kg/day) % aPAD Dietary Exposure(mg/kg/day) % cPAD

General U.S. Population 0.008199 <1 0.003105 6.7

All Infants (<1 year old) 0.026256 <1 0.008506 18

Children 1-2 years old 0.014271 <1 0.005786 13

Children 3-5 years old 0.011052 <1 0.004637 10

Children 6-12 years old 0.008171 <1 0.003098 6.7

Youth 13-19 years old 0.006825 <1 0.002347 5.1

Adults 20-49 years old 0.007652 <1 0.002943 6.4

Adults 50-99 years old 0.006909 <1 0.002867 6.2

Females 13-49 years old 0.007849 <1 0.002923 6.4

*The values for the highest exposed population for each type of risk assessment are bolded.

VIII. Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk estimates are conservative since they assumed 

100% CT, DEEM 7.81 default concentration factors, and tolerance-level or higher residues and 

were based on screening level estimates of drinking water concentrations generated by Tier I 

Rice modeling. They could be further refined through the use of anticipated residues, empirical 

processing factors and % CT data, as well as refined drinking water estimates.

IX. Conclusions

The acute and chronic dietary exposure and risk analyses using DEEM-FCID indicates that 

dietary risks to saflufenacil from food and drinking water are well below HED’s levels of 

concern for this pesticide. Estimated acute dietary risks are <1% of the aPAD at the 95th

percentile for the general U.S. population and all population subgroups and estimated chronic 

dietary risks are ≤18% of the cPAD for the general U.S. population and all population subgroups. 

HED is confident that the assessment does not underestimate risk to the general U.S. population 

or any population subgroup. 

X. List of Attachments

· Acute Food plus Water Residue Input File.

· Acute Results File.

· Chronic Food plus Water Residue Input File.

· Chronic Results File.

cc: G. Kramer (RAB1)

RDI: DESAC (8/8/13)

G.F. Kramer:S10957:PY-S:(703)305-5079:7509P:RAB1
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\gkramer\My 

Documents\Gk\##Saflufenacil\SAFLUFENACIL_ACUTE.R08

Chemical: Saflufenacil

RfD(Chronic): .046 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 08-08-2013/09:20:20 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0600347000 6 Soybean, seed 0.170000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.170000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.170000 1.000 1.000 

0600350000 6 Soybean, oil 0.170000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.170000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.030000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.030000 1.000 1.000 

0601257000 6A Pea, edible podded, succulent 0.030000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.030000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.030000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.030000 1.000 1.000 

0602255000 6B Pea, succulent 0.030000 1.000 1.000 

0602255001 6B Pea, succulent-babyfood 0.030000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 0.030000 1.000 1.000 

0603030000 6C Bean, black, seed 0.510000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.510000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.510000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.510000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.510000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.510000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.510000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.510000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.510000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.510000 1.000 1.000 

0603098000 6C Chickpea, seed 0.510000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.510000 1.000 1.000 

0603099000 6C Chickpea, flour 0.510000 1.000 1.000 

0603182000 6C Guar, seed 0.510000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.510000 1.000 1.000 

0603203000 6C Lentil, seed 0.510000 1.000 1.000 

0603256000 6C Pea, dry 0.510000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.510000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.510000 1.000 1.000 

0603348000 6C Soybean, flour 0.170000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.170000 1.000 1.000 

1001106000 10A Citron 0.030000 1.000 1.000 

1001107000 10A Citrus hybrids 0.030000 1.000 1.000 

1001108000 10A Citrus, oil 0.030000 1.000 1.000 

1001240000 10A Orange 0.030000 1.000 1.000 

1001241000 10A Orange, juice 0.030000 1.800 1.000 

1001241001 10A Orange, juice-babyfood 0.030000 1.800 1.000 

1001242000 10A Orange, peel 0.030000 1.000 1.000 

1001369000 10A Tangerine 0.030000 1.000 1.000 

1001370000 10A Tangerine, juice 0.030000 2.300 1.000 

1002197000 10B Kumquat 0.030000 1.000 1.000 

1002199000 10B Lemon 0.030000 1.000 1.000 

1002200000 10B Lemon, juice 0.030000 2.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.030000 2.000 1.000 

1002201000 10B Lemon, peel 0.030000 1.000 1.000 

1002206000 10B Lime 0.030000 1.000 1.000 

1002207000 10B Lime, juice 0.030000 2.000 1.000 

1002207001 10B Lime, juice-babyfood 0.030000 2.000 1.000 

1003180000 10C Grapefruit 0.030000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.030000 2.100 1.000 

1003307000 10C Pummelo 0.030000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.030000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.030000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 10 of 18

1100009000 11 Apple, dried 0.030000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.030000 8.000 1.000 

1100010000 11 Apple, juice 0.030000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.030000 1.300 1.000 

1100011000 11 Apple, sauce 0.030000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.030000 1.000 1.000 

1100129000 11 Crabapple 0.030000 1.000 1.000 

1100210000 11 Loquat 0.030000 1.000 1.000 

1100266000 11 Pear 0.030000 1.000 1.000 

1100266001 11 Pear-babyfood 0.030000 1.000 1.000 

1100267000 11 Pear, dried 0.030000 6.250 1.000 

1100268000 11 Pear, juice 0.030000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.030000 1.000 1.000 

1100310000 11 Quince 0.030000 1.000 1.000 

1201090000 12A Cherry 0.030000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.030000 1.000 1.000 

1201091000 12A Cherry, juice 0.030000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.030000 1.500 1.000 

1202012000 12B Apricot 0.030000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.030000 1.000 1.000 

1202013000 12B Apricot, dried 0.030000 6.000 1.000 

1202014000 12B Apricot, juice 0.030000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.030000 1.000 1.000 

1202230000 12B Nectarine 0.030000 1.000 1.000 

1202260000 12B Peach 0.030000 1.000 1.000 

1202260001 12B Peach-babyfood 0.030000 1.000 1.000 

1202261000 12B Peach, dried 0.030000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.030000 7.000 1.000 

1202262000 12B Peach, juice 0.030000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.030000 1.000 1.000 

1203285000 12C Plum 0.030000 1.000 1.000 

1203285001 12C Plum-babyfood 0.030000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.030000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.030000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.030000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.030000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.030000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.030000 1.400 1.000 

1304175000 13D Grape 0.030000 1.000 1.000 

1304176000 13D Grape, juice 0.030000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 0.030000 1.200 1.000 

1304179000 13D Grape, wine and sherry 0.030000 1.000 1.000 

1400003000 14 Almond 0.030000 1.000 1.000 

1400003001 14 Almond-babyfood 0.030000 1.000 1.000 

1400004000 14 Almond, oil 0.030000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.030000 1.000 1.000 

1400059000 14 Brazil nut 0.030000 1.000 1.000 

1400068000 14 Butternut 0.030000 1.000 1.000 

1400081000 14 Cashew 0.030000 1.000 1.000 

1400092000 14 Chestnut 0.030000 1.000 1.000 

1400155000 14 Hazelnut 0.030000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.030000 1.000 1.000 

1400185000 14 Hickory nut 0.030000 1.000 1.000 

1400213000 14 Macadamia nut 0.030000 1.000 1.000 

1400269000 14 Pecan 0.030000 1.000 1.000 

1400282000 14 Pistachio 0.030000 1.000 1.000 

1400391000 14 Walnut 0.030000 1.000 1.000 

1500025000 15 Barley, pearled barley 0.030000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.030000 1.000 1.000 

1500026000 15 Barley, flour 0.030000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.030000 1.000 1.000 

1500027000 15 Barley, bran 0.030000 1.000 1.000 

1500065000 15 Buckwheat 0.030000 1.000 1.000 

1500066000 15 Buckwheat, flour 0.030000 1.000 1.000 

1500120000 15 Corn, field, flour 0.030000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.030000 1.000 1.000 

1500121000 15 Corn, field, meal 0.030000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.030000 1.000 1.000 

1500122000 15 Corn, field, bran 0.030000 1.000 1.000 

1500123000 15 Corn, field, starch 0.030000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 11 of 18

1500124000 15 Corn, field, syrup 0.030000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.030000 1.500 1.000 

1500125000 15 Corn, field, oil 0.030000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.030000 1.000 1.000 

1500126000 15 Corn, pop 0.030000 1.000 1.000 

1500127000 15 Corn, sweet 0.030000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.030000 1.000 1.000 

1500226000 15 Millet, grain 0.030000 1.000 1.000 

1500231000 15 Oat, bran 0.030000 1.000 1.000 

1500232000 15 Oat, flour 0.030000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.030000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.030000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.030000 1.000 1.000 

1500323000 15 Rice, white 0.030000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.030000 1.000 1.000 

1500324000 15 Rice, brown 0.030000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.030000 1.000 1.000 

1500325000 15 Rice, flour 0.030000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.030000 1.000 1.000 

1500326000 15 Rice, bran 0.030000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.030000 1.000 1.000 

1500328000 15 Rye, grain 0.030000 1.000 1.000 

1500329000 15 Rye, flour 0.030000 1.000 1.000 

1500344000 15 Sorghum, grain 0.030000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.030000 1.000 1.000 

1500381000 15 Triticale, flour 0.030000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.030000 1.000 1.000 

1500401000 15 Wheat, grain 0.030000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.030000 1.000 1.000 

1500402000 15 Wheat, flour 0.030000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.030000 1.000 1.000 

1500403000 15 Wheat, germ 0.030000 1.000 1.000 

1500404000 15 Wheat, bran 0.030000 1.000 1.000 

1500405000 15 Wild rice 0.030000 1.000 1.000 

2001163000 20A Flax seed, oil 0.760000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.760000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.760000 1.000 1.000 

2001336000 20A Sesame, seed 0.760000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.760000 1.000 1.000 

2001337000 20A Sesame, oil 0.760000 1.000 1.000 

2001337001 20A Sesame, oil-babyfood 0.760000 1.000 1.000 

2002330000 20B Safflower, oil 1.700000 1.000 1.000 

2002330001 20B Safflower, oil-babyfood 1.700000 1.000 1.000 

2002364000 20B Sunflower, seed 1.700000 1.000 1.000 

2002365000 20B Sunflower, oil 1.700000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 1.700000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.340000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.340000 1.000 1.000 

3100044000 31 Beef, meat 0.010000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.010000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.010000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

3100047000 31 Beef, fat 0.010000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.010000 1.000 1.000 

3100048000 31 Beef, kidney 0.050000 1.000 1.000 

3100049000 31 Beef, liver 2.500000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 2.500000 1.000 1.000 

3200169000 32 Goat, meat 0.010000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 

3200171000 32 Goat, fat 0.010000 1.000 1.000 

3200172000 32 Goat, kidney 0.050000 1.000 1.000 

3200173000 32 Goat, liver 2.500000 1.000 1.000 

3300189000 33 Horse, meat 0.010000 1.000 1.000 

3400290000 34 Pork, meat 0.010000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.010000 1.000 1.000 

3400291000 34 Pork, skin 0.010000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

3400293000 34 Pork, fat 0.010000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.010000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 12 of 18

3400294000 34 Pork, kidney 0.010000 1.000 1.000 

3400295000 34 Pork, liver 0.800000 1.000 1.000 

3500339000 35 Sheep, meat 0.010000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.010000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 

3500341000 35 Sheep, fat 0.010000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.010000 1.000 1.000 

3500342000 35 Sheep, kidney 0.050000 1.000 1.000 

3500343000 35 Sheep, liver 2.500000 1.000 1.000 

3600222000 36 Milk, fat 0.010000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

3600224000 36 Milk, water 0.010000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

3900312000 39 Rabbit, meat 0.010000 1.000 1.000 

8000157000 80 Fish-freshwater finfish 0.010000 1.000 1.000 

8000158000 80 Fish-freshwater finfish, farm ra 0.010000 1.000 1.000 

8000159000 80 Fish-saltwater finfish, tuna 0.010000 1.000 1.000 

8000160000 80 Fish-saltwater finfish, other 0.010000 1.000 1.000 

8000161000 80 Fish-shellfish, crustacean 0.010000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.133000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.133000 1.000 1.000 

9500023000 O Banana 0.030000 1.000 1.000 

9500023001 O Banana-babyfood 0.030000 1.000 1.000 

9500024000 O Banana, dried 0.030000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.030000 3.900 1.000 

9500115000 O Coffee, roasted bean 0.030000 1.000 1.000 

9500116000 O Coffee, instant 0.030000 1.000 1.000 

9500177000 O Grape, leaves 0.030000 1.000 1.000 

9500178000 O Grape, raisin 0.030000 4.300 1.000 

9500215000 O Mango 0.030000 1.000 1.000 

9500216000 O Mango, dried 0.030000 1.000 1.000 

9500217000 O Mango, juice 0.030000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.030000 1.000 1.000 

9500283000 O Plantain 0.030000 1.000 1.000 

9500284000 O Plantain, dried 0.030000 1.000 1.000 

9500362000 O Sugarcane, sugar 0.050000 1.000 1.000 

9500362001 O Sugarcane, sugar-babyfood 0.050000 1.000 1.000 

9500363000 O Sugarcane, molasses 0.080000 1.000 1.000 

9500363001 O Sugarcane, molasses-babyfood 0.080000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 13 of 18

Acute Results File.

EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for SAFLUFENACIL NHANES 2003-2008 2-Day

Residue file: SAFLUFENACIL_ACUTE.R08 Adjustment factor #2 used.

Analysis Date: 08-27-2013/15:12:34 Residue file dated: 08-27-2013/15:09:55

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.008199 0.16 0.013523 0.27 0.025641 0.51 

All Infants:

 0.026256 0.53 0.034048 0.68 0.050261 1.01 

Children 1-2:

 0.014271 0.29 0.021256 0.43 0.044029 0.88 

Children 3-5:

 0.011052 0.22 0.015952 0.32 0.024441 0.49 

Children 6-12:

 0.008171 0.16 0.012431 0.25 0.018932 0.38 

Youth 13-19:

 0.006825 0.14 0.010675 0.21 0.015523 0.31 

Adults 20-49:

 0.007652 0.15 0.011132 0.22 0.016150 0.32 

Adults 50-99:

 0.006909 0.14 0.010361 0.21 0.015754 0.32 

Female 13-49:

 0.007849 0.16 0.011152 0.22 0.015397 0.31
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 14 of 18

Chronic Food plus Water Residue Input File.

Filename: C:\Documents and Settings\gkramer\My 

Documents\Gk\##Saflufenacil\SAFLUFENACIL_CHRONIC.R08

Chemical: Saflufenacil

RfD(Chronic): .046 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 08-08-2013/09:07:46 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

9500023000 O Banana 0.030000 1.000 1.000 

9500024000 O Banana, dried 0.030000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.030000 3.900 1.000 

9500023001 O Banana-babyfood 0.030000 1.000 1.000 

9500116000 O Coffee, instant 0.030000 1.000 1.000 

9500115000 O Coffee, roasted bean 0.030000 1.000 1.000 

9500177000 O Grape, leaves 0.030000 1.000 1.000 

9500178000 O Grape, raisin 0.030000 4.300 1.000 

9500215000 O Mango 0.030000 1.000 1.000 

9500216000 O Mango, dried 0.030000 1.000 1.000 

9500217000 O Mango, juice 0.030000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.030000 1.000 1.000 

9500283000 O Plantain 0.030000 1.000 1.000 

9500284000 O Plantain, dried 0.030000 1.000 1.000 

9500363000 O Sugarcane, molasses 0.080000 1.000 1.000 

9500363001 O Sugarcane, molasses-babyfood 0.080000 1.000 1.000 

9500362000 O Sugarcane, sugar 0.050000 1.000 1.000 

9500362001 O Sugarcane, sugar-babyfood 0.050000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.510000 1.000 1.000 

0603030000 6C Bean, black, seed 0.510000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.510000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.030000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.510000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.030000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.510000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.510000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.030000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.510000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.510000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.510000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.510000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.030000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.030000 1.000 1.000 

0603099000 6C Chickpea, flour 0.510000 1.000 1.000 

0603098000 6C Chickpea, seed 0.510000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.510000 1.000 1.000 

0603182000 6C Guar, seed 0.510000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.510000 1.000 1.000 

0603203000 6C Lentil, seed 0.510000 1.000 1.000 

0603256000 6C Pea, dry 0.510000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.510000 1.000 1.000 

0601257000 6A Pea, edible podded, succulent 0.030000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.510000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 0.030000 1.000 1.000 

0602255000 6B Pea, succulent 0.030000 1.000 1.000 

0602255001 6B Pea, succulent-babyfood 0.030000 1.000 1.000 

0603348000 6C Soybean, flour 0.170000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.170000 1.000 1.000 

0600350000 6 Soybean, oil 0.170000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.170000 1.000 1.000 

0600347000 6 Soybean, seed 0.170000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.170000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.170000 1.000 1.000 

1001106000 10A Citron 0.030000 1.000 1.000 

1001107000 10A Citrus hybrids 0.030000 1.000 1.000 

1001108000 10A Citrus, oil 0.030000 1.000 1.000 

1003180000 10C Grapefruit 0.030000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.030000 2.100 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 15 of 18

1002197000 10B Kumquat 0.030000 1.000 1.000 

1002199000 10B Lemon 0.030000 1.000 1.000 

1002200000 10B Lemon, juice 0.030000 2.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.030000 2.000 1.000 

1002201000 10B Lemon, peel 0.030000 1.000 1.000 

1002206000 10B Lime 0.030000 1.000 1.000 

1002207000 10B Lime, juice 0.030000 2.000 1.000 

1002207001 10B Lime, juice-babyfood 0.030000 2.000 1.000 

1001240000 10A Orange 0.030000 1.000 1.000 

1001241000 10A Orange, juice 0.030000 1.800 1.000 

1001241001 10A Orange, juice-babyfood 0.030000 1.800 1.000 

1001242000 10A Orange, peel 0.030000 1.000 1.000 

1003307000 10C Pummelo 0.030000 1.000 1.000 

1001369000 10A Tangerine 0.030000 1.000 1.000 

1001370000 10A Tangerine, juice 0.030000 2.300 1.000 

1100009000 11 Apple, dried 0.030000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.030000 8.000 1.000 

1100007000 11 Apple, fruit with peel 0.030000 1.000 1.000 

1100010000 11 Apple, juice 0.030000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.030000 1.300 1.000 

1100008000 11 Apple, peeled fruit 0.030000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.030000 1.000 1.000 

1100011000 11 Apple, sauce 0.030000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.030000 1.000 1.000 

1100129000 11 Crabapple 0.030000 1.000 1.000 

1100210000 11 Loquat 0.030000 1.000 1.000 

1100266000 11 Pear 0.030000 1.000 1.000 

1100267000 11 Pear, dried 0.030000 6.250 1.000 

1100268000 11 Pear, juice 0.030000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.030000 1.000 1.000 

1100266001 11 Pear-babyfood 0.030000 1.000 1.000 

1100310000 11 Quince 0.030000 1.000 1.000 

1202012000 12B Apricot 0.030000 1.000 1.000 

1202013000 12B Apricot, dried 0.030000 6.000 1.000 

1202014000 12B Apricot, juice 0.030000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.030000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.030000 1.000 1.000 

1201090000 12A Cherry 0.030000 1.000 1.000 

1201091000 12A Cherry, juice 0.030000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.030000 1.500 1.000 

1201090001 12A Cherry-babyfood 0.030000 1.000 1.000 

1202230000 12B Nectarine 0.030000 1.000 1.000 

1202260000 12B Peach 0.030000 1.000 1.000 

1202261000 12B Peach, dried 0.030000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.030000 7.000 1.000 

1202262000 12B Peach, juice 0.030000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.030000 1.000 1.000 

1202260001 12B Peach-babyfood 0.030000 1.000 1.000 

1203285000 12C Plum 0.030000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.030000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.030000 5.000 1.000 

1203286000 12C Plum, prune, fresh 0.030000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.030000 1.000 1.000 

1203288000 12C Plum, prune, juice 0.030000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.030000 1.400 1.000 

1203285001 12C Plum-babyfood 0.030000 1.000 1.000 

1304175000 13D Grape 0.030000 1.000 1.000 

1304176000 13D Grape, juice 0.030000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 0.030000 1.200 1.000 

1304179000 13D Grape, wine and sherry 0.030000 1.000 1.000 

1400003000 14 Almond 0.030000 1.000 1.000 

1400004000 14 Almond, oil 0.030000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.030000 1.000 1.000 

1400003001 14 Almond-babyfood 0.030000 1.000 1.000 

1400059000 14 Brazil nut 0.030000 1.000 1.000 

1400068000 14 Butternut 0.030000 1.000 1.000 

1400081000 14 Cashew 0.030000 1.000 1.000 

1400092000 14 Chestnut 0.030000 1.000 1.000 

1400155000 14 Hazelnut 0.030000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.030000 1.000 1.000 

1400185000 14 Hickory nut 0.030000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 16 of 18

1400213000 14 Macadamia nut 0.030000 1.000 1.000 

1400269000 14 Pecan 0.030000 1.000 1.000 

1400282000 14 Pistachio 0.030000 1.000 1.000 

1400391000 14 Walnut 0.030000 1.000 1.000 

1500027000 15 Barley, bran 0.030000 1.000 1.000 

1500026000 15 Barley, flour 0.030000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.030000 1.000 1.000 

1500025000 15 Barley, pearled barley 0.030000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.030000 1.000 1.000 

1500065000 15 Buckwheat 0.030000 1.000 1.000 

1500066000 15 Buckwheat, flour 0.030000 1.000 1.000 

1500122000 15 Corn, field, bran 0.030000 1.000 1.000 

1500120000 15 Corn, field, flour 0.030000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.030000 1.000 1.000 

1500121000 15 Corn, field, meal 0.030000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.030000 1.000 1.000 

1500125000 15 Corn, field, oil 0.030000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.030000 1.000 1.000 

1500123000 15 Corn, field, starch 0.030000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.030000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.030000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.030000 1.500 1.000 

1500126000 15 Corn, pop 0.030000 1.000 1.000 

1500127000 15 Corn, sweet 0.030000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.030000 1.000 1.000 

1500226000 15 Millet, grain 0.030000 1.000 1.000 

1500231000 15 Oat, bran 0.030000 1.000 1.000 

1500232000 15 Oat, flour 0.030000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.030000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.030000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.030000 1.000 1.000 

1500326000 15 Rice, bran 0.030000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.030000 1.000 1.000 

1500324000 15 Rice, brown 0.030000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.030000 1.000 1.000 

1500325000 15 Rice, flour 0.030000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.030000 1.000 1.000 

1500323000 15 Rice, white 0.030000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.030000 1.000 1.000 

1500329000 15 Rye, flour 0.030000 1.000 1.000 

1500328000 15 Rye, grain 0.030000 1.000 1.000 

1500344000 15 Sorghum, grain 0.030000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.030000 1.000 1.000 

1500381000 15 Triticale, flour 0.030000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.030000 1.000 1.000 

1500404000 15 Wheat, bran 0.030000 1.000 1.000 

1500402000 15 Wheat, flour 0.030000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.030000 1.000 1.000 

1500403000 15 Wheat, germ 0.030000 1.000 1.000 

1500401000 15 Wheat, grain 0.030000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.030000 1.000 1.000 

1500405000 15 Wild rice 0.030000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.340000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.340000 1.000 1.000 

2001163000 20A Flax seed, oil 0.760000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.760000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.760000 1.000 1.000 

2002330000 20B Safflower, oil 1.700000 1.000 1.000 

2002330001 20B Safflower, oil-babyfood 1.700000 1.000 1.000 

2001337000 20A Sesame, oil 0.760000 1.000 1.000 

2001337001 20A Sesame, oil-babyfood 0.760000 1.000 1.000 

2001336000 20A Sesame, seed 0.760000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.760000 1.000 1.000 

2002365000 20B Sunflower, oil 1.700000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 1.700000 1.000 1.000 

2002364000 20B Sunflower, seed 1.700000 1.000 1.000 

3100047000 31 Beef, fat 0.010000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.010000 1.000 1.000 

3100048000 31 Beef, kidney 0.050000 1.000 1.000 

3100049000 31 Beef, liver 2.500000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 2.500000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

______________________________________________________________________________________

Page 17 of 18

3100044000 31 Beef, meat 0.010000 1.000 1.000 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.010000 1.920 1.000 

3100044001 31 Beef, meat-babyfood 0.010000 1.000 1.000 

3200171000 32 Goat, fat 0.010000 1.000 1.000 

3200172000 32 Goat, kidney 0.050000 1.000 1.000 

3200173000 32 Goat, liver 2.500000 1.000 1.000 

3200169000 32 Goat, meat 0.010000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 

3300189000 33 Horse, meat 0.010000 1.000 1.000 

3400293000 34 Pork, fat 0.010000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.010000 1.000 1.000 

3400294000 34 Pork, kidney 0.010000 1.000 1.000 

3400295000 34 Pork, liver 0.800000 1.000 1.000 

3400290000 34 Pork, meat 0.010000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.010000 1.000 1.000 

3400291000 34 Pork, skin 0.010000 1.000 1.000 

3500341000 35 Sheep, fat 0.010000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.010000 1.000 1.000 

3500342000 35 Sheep, kidney 0.050000 1.000 1.000 

3500343000 35 Sheep, liver 2.500000 1.000 1.000 

3500339000 35 Sheep, meat 0.010000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.010000 1.000 1.000 

3600222000 36 Milk, fat 0.010000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

3600224000 36 Milk, water 0.010000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.000 1.000 

3900312000 39 Rabbit, meat 0.010000 1.000 1.000 

8000157000 80 Fish-freshwater finfish 0.010000 1.000 1.000 

8000158000 80 Fish-freshwater finfish, farm ra 0.010000 1.000 1.000 

8000160000 80 Fish-saltwater finfish, other 0.010000 1.000 1.000 

8000159000 80 Fish-saltwater finfish, tuna 0.010000 1.000 1.000 

8000161000 80 Fish-shellfish, crustacean 0.010000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.120000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.120000 1.000 1.000 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 405747

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Page 18 of 18

Chronic Results File.

EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for SAFLUFENACIL NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\gkramer\My 

Documents\Gk\##Saflufenacil\SAFLUFENACIL_CHRONIC.R08

 Adjustment factor #2 used.

Analysis Date 08-27-2013/14:20:33 Residue file dated: 08-27-2013/14:18:10

Reference dose (RfD, Chronic) = .046 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.003105 6.7%

Hispanic 0.003163 6.9%

Non-Hisp-White 0.003137 6.8%

Non-Hisp-Black 0.002661 5.8%

Non-Hisp-Other 0.003570 7.8%

Nursing Infants 0.003135 6.8%

Non-Nursing Infants 0.010906 23.7%

Female 13+ PREG 0.002886 6.3%

Children 1-6 0.004956 10.8%

Children 7-12 0.002923 6.4%

Male 13-19 0.002267 4.9%

Female 13-19/NP 0.002426 5.3%

Male 20+ 0.002777 6.0%

Female 20+/NP 0.003033 6.6%

Seniors 55+ 0.002813 6.1%

All Infants 0.008506 18.5%

Female 13-50 0.002925 6.4%

Children 1-2 0.005786 12.6%

Children 3-5 0.004637 10.1%

Children 6-12 0.003098 6.7%

Youth 13-19 0.002347 5.1%

Adults 20-49 0.002943 6.4%

Adults 50-99 0.002867 6.2%

Female 13-49 0.002923 6.4%

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