Kasugamycin Dietary Exposure and Risk Assessment PC Code 23000 I DP Barcode 0415989


### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION


### MEMORANDUM DATE: 8 November 2013 SUBJECT: Kasugamycin. REVISED Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action Associated with Food/Feed Use ofthe Fungicide on Fruiting Vegetables (Group 8-10) , Porne Fruits (Group 11-10) , and Walnuts. 

### PC Code: 230001 

### Decision Number: 427886 

### Petition Number: OF7689 

### DP Barcode: D415989 

### Registration Number: 66330-404 

### Regulatory Action: Section 3 

### Case Number: 7045 

### Risk Assessment Type: Dietary 

### TXR Number: NA 

### CAS Number: 6980-18-3 (19408

-46 -9, HCl salt) 

### 40CFR: §180.614 

### MRID Number: NA 

### FROM:

THRU:

TO: and William T. Drew, Chemist

# ~ Ri sk Assessment Branch II (RAB2) Health Effects Division (HED), 7509P Douglas Dotson , PhJ?,

## Che~~ 

# A·**~;e-JQ1c.)** Torn Bloem,

### Chern**~~~** Dietary Exposure Science Advisory Council (DESAC) HED , 7509P William T. 

### Drew, Chemist and Ri sk Assessor RAB2/HED , 7509P Shaunta Hill and Hope Johnson , RM Team 21 Fungicide Branch (FB) Registration Division (RD), 7505P

Page 1 of9Kasugamycin Executive Summary Dietary Exposu r e and Risk Ass essment PC Code 23 000 I DP Barcode 0415989



### A rev i sed unre · fin ed chronic aggregate di etary (food and drinking water) exp os ure and risk assessment was conducted using the Dietary Exposure Evaluation Model softwar e with the Food Commodity Intake D atabase (DEEM-FCID), Ver s ion 3.16. This software uses 2003

-2008 food co n sumption data from the US D epa rtment of Agr iculture's (US D A's) National Health and Nu trition Examination S u rvey, What We Eat in America, (NHANES / WWEIA). The analysis was performed to s upp ort the Section 3 request for ka sugamycin use on fru iting vegetab les group 8-10 , pome fruits group 1 1 -1 0, and walnuts. All current and proposed uses of kasugamycin , as of the date of this m emorandum , are included in this assessment. Thi s revised die tary assessment was conduct ed to support HED 's d ec is ion to harmonize the recommended US tolerances with the max imum residue limits (MRLs) selec ted by Canada's Pes t Management Regulatory Agency (PMRA), which diff er from B ED 's prev iousl y recommended tolerances. This memorandum was reviewed b y two peer rev iewers ofthe DES AC, per DESAC SOP 2012.1. 

### Tol erance -level residues , and 100% crop treated (CT) were assumed for all raw ag ricultural commodities (RACs). DEEM def ault processing factors were used for all processed commodities excep t apple juice, for which the empirica l factor from the processing study was used. The analysi s inc luded direct incorporation of modeled estimated kas ugamycin residues in drinking water. The est imated drinking water concentration (EDWC) in sur face water is 0.001178 ppm for chronic exposure. Thi s EDW C in surface water (0.00 1178 ppm) was used for the chronic di etary analysis s ince it i s higher than the groundwater EDWC. Based on these hi ghly conservative assumptions , chronic dietary risk estimates a re less than or equal to 3.1% of the chro ni c population-adjusted d ose (cPAD) for all population su bgroup s. Children 1-2 years of age is the most hi g hly- exposed subgroup , utilizing 3.1% of the cPAD, while the general US population utili ze s < 1.0% ofthe cPAD. Generall y, H ED is concerned whe n ris k estimate s exceed 100% of the PAD ; therefore , all chronic di etary risk es ti mates are not of concern. An acute dietary endpo int was not selected for kas u gamyc in
. As a resu lt , acute dietary risk i s not o f co ncern. Kasugamycin has been classified by the Cancer Assessment Rev iew Committee (CARC) as "not likely to be ca rcinogenic"; therefore, cancer risk is not of co n cern .
1. Introduction 

### Dietary risk assessment incorporates both expos ure and toxicity of a given pesticide. For acute and chronic ass essments, the risk is expre ssed as a percentage of a max imum acceptable do se (t

he dose which HED has co ncluded will result in no unreasonable adve rse health effects). This dose i s referred to as the population

- adjusted dose ( PAD ). The PAD i s eq ui vale nt to the p oint of

P age 2 of9Kasugamycin Dietary Exposure and Risk Assessment PC Code 230001 DP Barcode 0415989 

### departure (POD), such as the no observed adverse effect level (NOAEL) or lowe st observed adverse effect level ( LOAEL) , divided by the requisite uncertainty and/or safety factors. For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA pesticides web site, Available Information on Assessing Exposure from Pesticides, A User's Guide (21 June 2000), which can be accessed via the web link http: //www.epa.gov/fedrgstr/EPA-PEST/2000/July/ Day-12/ 6061.pdf (or see 

### SOP 99.6, dated 20 August 1999). The most recent dietary ri sk assessment for kasugamycin was conducted by W.T. Drew (0390458; 13 July 2012). This current document incorporates changes in the tolerance levels resul ting from HED's decision to harmonize the recommended US tolerances with the MRLs selected by PMRA , which differ from HED 's previously recommended tolerances.


### 2. Residue Information This revis ed dietary assessment include s residue estimates supporting the requested Section 3 registration ofkasugamycin for use on fruiting vegetables (crop group 8-1 0) , pome fruits (crop group 11-1 0), and walnuts. The residue of concern, for both tolerance enforcement and risk assessment, is the parent compound, kasugamycin. Residues resulting from use of kasugamycin are assumed to be at the tolerance levels now being recommended by HED (0.1 0 ppm in fruiting vegetables group 8-10,0.20 ppm in pome fruits group 11-10, and 0.04 ppm in walnuts), in harmonization with PMRA 's MRL s. Default processing factors from DEEM 7.81 were used in the analysis, except for apple juice, for which the empirical factor from the processing study ( 1.5X) was used. A complete listing of the residues and processing factors used in the chronic dietary analysis is included in Attachment 1. Tolerances (without registration) have been established for kasugamycin (40C FR 

### § 180 .614) inion imported fruiting vegetables (crop gro up 8) at 0.04 ppm. A time -limited (Section 18) tolerance has also been establis hed at 0.05 ppm for kasugamycin inion apples grown in Michigan, with expiration date of 3 1 December 2015. These tolerances will be superseded by thos e listed above when the proposed new uses are regis tered.

Page 3 of9Kasugamycin Dietary Exposure and Risk Assessment PC Code 23000 I 

### 3. Percent Crop Treated Information DP Barcode 0415989



### The chronic assessment is highly conservative, and assumes that all crops with existing or currently requested uses bear residues of kasugamycin (in other words , 1 OO%CT).


### 4. Drinking Water Data The drinking water residues used in thi s dietary risk assessment were provided by EFED (D376600; T. 

### Dowen; 28 April 2011), and incorporated directly into the dietary assessment via entry into the food categories "water, direct, all sources" and "water, indirect, all sources . " The EDWCs in surface water are 0.011562 ppm and 0.001178 ppm for acute and chronic scenarios , respectively. The EDWC in groundwater is 0.000116 ppm for all durations (see Table 1, below). The chronic surface water EDWC (0.001178 ppm) was used in the chronic djetary analysis because it is the higher of the chrome residue s in water. The surface water EDWCs were obtained via exposure modeling which utilized the PRZM (Pesticide Root Zone Model) and EXAM S (EXposure Analysis Modeling System) models
. These models and their description s are available at the EPA internet website via the web link, http: //www.epa.gov/oppefedl /models/water /
. The PRZMIEXAMS modeling was based on application of kasugamycin to tomatoe s in Florida. 

### TABLE! EDWCs for Kasugamycin, Plus Degradates K a sugamycinic Acid a nd Kasuganobiosamine. Crop 

# I Acute Expos ure ( ppm) 

# I Chronic Exposu re (ppm) 

# I Cancer Exposure (ppm) Surface Water (via PRZM/EXAMS) Tomato 

# J 0.011562 

# I 0.001178* 

## I 0.000602 Ground Water (via SCI

- G ROW) Walnut 

## I 0.0001 1 6 

## I 0.0001 16 

# I 0.0001 16 

### * EDWC used m the chrome d1etary assessment.


### 5. DEEM

-FCID Program and Consumption Information The kasugamycin chronic dietary exposure assessment was conducted using DEEM-FCID (Version 3 .16) which incorporates 2003-2008 consumption data from USDA's NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individual s over two non-consecutive survey days. Foods "as consumed" (such as apple pie) are linked to EPA -defined food commodities (such as apples, peeled fruit- cooked, fresh/unspecified , or baked ; or wheat flour

- cooked, fresh/unspecified, or baked) using pub licly available recipe translation files developed jointly by US DA/ ARS and EPA. For chronic Page 4 of9Kasugamycin Dietary Exposure and Risk Assessment PC Code 23000 I DP Barcode 0415989 

### exposure assessment, consumption data are averaged for the entire US population, and within population subgro ups. However, for acute exposure assessment, they are retained as individual consumption events. Based on analysis ofthe 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general US population, all infants (<1 year old) , children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13 -4 9, and adults 50-99 years o ld. For chronic dietary exposure assessment, an estima te ofthe residue level in each food or foodform (such as orange or orange j uic e) on th e food commodity residue li st is multiplied by the average dail y consumption estimate for that food/food form. The resu lting residue consumption estimate for each food/food fo rm is summed w ith the res idue consumption estimates for all other food/food forms on the commodity residue list to arrive at t he total average estima ted exposure . Exposure is expressed in mg/kg body weight /day, and as a percent ofth e cPAD
. Thi s procedure is performed for each popul ation subgroup . For acute exposure assessments, individu al one-day food consumption data are used on an individual-by- ind ividual basis
. The reported consumption amounts of each food item can be multip li ed by a residue point estimate , and summed to obtain a tota l dail y pesticide exposure fo r a deterministic exposure assessment, or "matched" in mul tiple random pairings with residue values, and then summed in a probab ili stic assessment. T he resu lting distributi on of exposures is expressed as a percentage of the aPA D on both a user (those who reported eati ng relevant commodities/f ood forms) and a per- capita (those who reported eating the relevant commodities as well as those who did not) basis
. In accordance with HED policy, per capita expo sure and risk are reporte d for a ll di etary analyses, re gardle ss of the degree ofrefinement (unrefined through highly refined). However, for unrefined or slightly refined analyses, significant differences in user versus per capita exposure and risk are identified, and noted in the risk assessment.


### 6. Toxicological Information For detailed information, please refer to the human health ri sk assessment conduc ted for kasugamycin's use on fruiting vegetables, pome frui t, and walnuts (D376608; W
.T. Drew; 13 July 2012). The avai l able database is considered ofhigh quality, and is adequate for assessment of risk for the proposed uses. The chronic reference dose (cRfD) is 0
. 1 1 mg/kg/day
. The NOAEL of 11 mg/kg/day is fro m the rat chronic t oxicity/carcinogenicity study. T his NOAEL was selected for the c RfD because it was of the approp riate route and duration, and is protective of effects seen in other studies
. Although the testicular findings were not statistically s ignificant compared to controls, these effects were selected as the bas i s for the study LOAEL because the incidence and severity were increased, and similar degenerati ve tes ti cul ar effects were seen across species. The sele cted
P age 5 of9Kasugamycin Dietary Exposure and Risk Assessment PC Code 230001 DP Barcode D 41 5989 

### endpoint is also protective of maternal and deve lopmental tox icity (weight los s, decreased food consumption during dosing, abortion in one female, and decreased fetal weight) that was seen in the rabbit developmental toxicity range -finding study
. No developmental toxicity was seen in the rat, and maternal toxicity was seen at 1000 mg/kg/day (200 mg/kg/day). The risk assessment team has confirmed that the selected doses and endpoints are appropriate to assess the currently proposed uses on fruiting vegetables, pome fruit, and walnuts
. These doses and endpoints are summarized in Tab le 2, below . TABLE2 Summary of Kasugamycin Toxicological Doses and Endpoints for Use in Dietary Human Health Risk Assessments. Exposure Scenario Point of Uncerta int y RID, PAD for Risk Study and Toxicological Effects Departure and FQPA Assessment Safety Factors Acute dietary Not required. Appropriate endpoints for this risk assessment scenario were not identified , (all populations) based on a lack of single -do se effects in th e database
. Chronic dietary N OAEL = 11 UFA = lOX Chronic RID = 0.11 Combined chronic (all populations, mg/kg/d ay UFH= lOX mg/kg/day toxicity / carcinogenicity study in including infants and F QPA SF= IX the rat. LOAEL = 116 children, and females cPAD = O.Il mg/kg/day , based on testicular age 13 to 49) mg/kg/day atrophy and softening. Cancer Classification: "Not likely to be carcinogenic to humans." No oncogenic pote ntial was (oral, dermal , noted in either the mouse oncogenicity or in the rat combined chronic/ carcinogen ic ity inhalation) studies. Additionally, no mutagenic potential was noted in any of the mutagenicity studies. Pomt of Departure (POD) = a data pomt or estimated pomt denved from observed dose

- response data, wh1ch IS used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. UF = Uncertainty Factor. UFA =extrapolation from animal to human (interspecies)
. UFH = potential variation in sensitivity among members of the human population (intraspecies). FQPA S F= FQPA Safety Factor. NOAEL = No Observed Adverse Effect Level. LOAEL = Lowest Observed Adverse Effect Leve l. PAD = Population Adjusted Dos e (a = acute , c =chronic). RID = Referenc e Dose
. 

### 7
. Results/Discussion As previously stated, for chro nic assessments, HED is concerned when dietary risk exceeds 100% of the cPAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the US population and the various population subgroups. The results of the chronic analysis are summarized in Table 3, below. The exposure estima t es are considered very conservative because tolerance-level residues , and 100% CT, were assumed
. As indicated in Table 3, the chronic risk estimates are not of concern for any of the population subgroups. Children 1

- 2 years of age is the most highly-exposed subgroup, utili zing 3.1% of the cPAD, while the general US population utilizes <1.0% of the cPAD. Page 6 of9Kasugamycin Dietary Exposure and Risk Assessment PC Code 230001 DP Barcode 04 15989
TABLE3 Sum mary of Chronic Dietary Exposure and Risk Estimates for Kasugamvcio. Population Subgroup* cPAD (mg/kg/day) Dietary Exposure Estimate %cPAD (Years of Age ] (mg/kg/day) General US Population 0
. 11 0.000526 < 1.0 All Infants [ < 1] 0
. 11 0
.001899 1.7 Children [1-2) 0.11 0
. 003385 3.1 Children [3-5] 0.11 0.002015 1.8 Children [6-12] 0.11 0.000840 < 1.0 Youth [13

- 19] 0.11 0
. 000367 < 1.0 Adults ( 20-49) 0.11 0.000295 < 1.0 Adults [50-99] 0.11 0
. 000264 < 1.0 F

e males (13

-49] 0.11 0.000299 < 1.0 * Values for the populatton subgroup w1th the highest risk are in bold type.


### 8. Characterization of Inputs/Outputs This chronic dietary exposure and risk assessment i s based on tolerance-level residues, default processing factors (except for the l.SX apple juice empirical factor, which is greater than the default factor of 1.3X), and assumes that all crops with either current or proposed kasugamycin tolerances are treated (1 OO%CT). These assumptions result in highly conservative, healthprotective es t imates of dietary exposure and risk.


### 9. Conclus ions An unrefined chronic dietary assessment was conducted for all current and proposed u ses of kasugamyc in . T here are no dietary exposure considerations that would preclude the establishment of tolerances for residues of kasugamycin inion fruiting vegetab les group 8-10, pome fruits group 1 1 -1 0 , and walnuts. All population subgroups have risk estimates that are below H ED ' s level of concern. HED is confident that the assessment does not underestimate risk to the general U S population or any populati on su bgroup.


### 1 0. List of Attachments Attachment 1. Kasugamycin Residues Used for Chronic Dietary Exposure Estimates. Attachment 2. Summary of the Chronic Dietary Exposure and Risk Estimates for Kasugamycin.

Page 7 of9Kasugamycin D ietary Exposure and Risk As ses sment PC Code 23000 I DP Barcode 0415989 

### Attachment 1. 

### Kasugamycin Residues Used for Chronic Dietary E xposure E stimates.
F i lename: C : \ D o cume n t s a n d S e t ti n g s\wdre w\ M y D o cume n t s \Ka s ugamyc inD EE M 11 0S 1 3 I n put .ROS Chem i ca l : Kasugam yc i n RfD (C hroni c) : . 1 1 mg / kg b w/ d ay NOEL(Chro n i c ): 0 mg / k g bw/day Rf D ( Acut e): 0 mg / kg bw/da y NO EL(Acute ): 0 mg / kg bw/ day Date c reate d /last m o d i fie d: 1 1

- 0 S

- 2 0 13 /0 S: 0 1:4 5 Program ve r . 3.1 6, 03

- 0S

- d Crop E PA Code Grp C omm odity N ame 11 0 00 0 90 00 11 11 000 0 90 0 1 11 1 1000 07 0 00 11 11 0 00 1 00 00 11 1 1 0 00 1 0 00 1 11 11 000 0 800 0 1 1 11 0 00 0S 0 0 1 11 1 1 0 001 1 00 0 11 1 1 0 001100 1 11 11 0 0 1 2 900 0 11 0 80 2 1 4S OO O SB C 11 0 017 3 50 0 11 1 10 0 2 1 0 00 0 11 0 8022 3 4 00 0 SB C 11 002 6 6 00 0 11 11 00 267000 1 1 11 002680 0 0 11 110 0 26 8 00 1 11 11 0 0 266001 11 080 22 70 000 8B 08 0 22710 00 SB 080 2271 00 1 8B 08022 7 0 0 01 8 B 0802272 0 00 8 BC 08 0 22 73 0 00 SB C 0 80 22 7 20 0 1 S BC 110 0 3 1 0 0 00 11 080 1 3 7 4 0 00 SA O

S01 3750 00 S A OS 01 3S OO OO S A O

S01 3 7 80 00 SA OS 01 37S00 1 SA OS 0 13 7 90 00 SA OS 0 1 3 76 0 00 S A 0 80 137 6 0 0 1 SA 0 80 13770 00 S A O

S01 3770 0 1 S A OS 01 37 5 00 1 SA 14 0 03 9 10 00 1 4 86 0 1 0 00000 S6A S 6 02 0 00 00 0 S6B Apple, d ri ed Apple , drie d

- b abyfo o d A

p p l e , fr u it w i th pee l A

p p l e, ju i c e App le, ju i ce - bab yfoo d Apple , p ee l e d frui t A

p p l e , pee l ed fru it- bab yfoo d App l e, s au c e App le, s au c e - bab yfoo d c rabapple Eg g p l a n t Goj i ber ry Lo quat O

k r a Pear Pe a r , d r i e d Pear , j u i c e Pear , j u i ce - babyfo o d Pear

- babyfood P epp er, bell Pepp e r, b e ll, dr i ed Pe p per , b e ll, dr i e d

- b aby f o od Pepper , bel l

- b aby f o od Pepp er, no nbe 11 Pepp er , no nbe l l, d r i ed Pe pp er , nonbel l

- baby f ood Qu i n c e Toma t i l l o T o m a t o T o m a t o, T r ee T o m a t o, d r ied T o m a t o, d r ied

- baby f o o d Tom a t o, ju i c e Tomat o, pa s t e T o ma t o , pa s t e - b abyf oo d T o ma t o, p uree T o m a t o, puree - b abyf oo d T o m a t o - b aby f o o d Wa l nut W

a t er, d i rec t , a l l sou rc es W

ate r , indir ec t , al l sourc e s



### Page 8 of9 Def R e s ( ppm ) 0. 2 00 000 0.200 00 0 0
. 2 0 0 000 0 .2 00 00 0 0.200 000 0. 20 0 000 0 .20 0 000 0 .20 0 000 0. 20 0 000 0.2 0 00 00 0. 10 0 000 0
. 10 00 00 0.2 0 0 000 0 .10 0 000 0.2 00 0 00 0.200 0 00 0
. 2 0 00 00 0.20 00 00 0. 20 00 00 0. 10 00 00 0
. 100 0 00 0
. 1 00 0 00 0. 1 00 00 0 0
. 100 00 0 0.100000 0
. 100 00 0 0
. 200 00 0 0
. 1 00 00 0 0 .1 00 00 0 0 .1 00 00 0 0 .1 000 0 0 0 .1 000 0 0 0 .1 000 0 0 0
. 100 00 0 0
. 100 00 0 0
. 100 00 0 0 .1 00 00 0 0
. 1 00 0 00 0.040 0 00 0. 0 011 7S 0
. 0 0 11 7 8 Ad j.Fac t or s # 1 # 2 

### s. ooo 8 .000 1
. 000 1
. 500 1
. 500 1. 000 1 .0 00 1. 000 1
. 000 1. 000 1
. 000 1. 000 1. 000 1.0 00 1. 0 00 6.250 1 .0 00 1 .0 00 l. 0 00 l. 0 00 1
. 0 00 l. 0 00 1
. 00 0 1. 0 00 1 .00 0 1
. 00 0 1
. 00 0 1
. 00 0 1
. 0 0 0 l. 0 0 0 1 4
. 3 0 0 14
. 3 0 0

1
. 500 5
. 4 0 0 5
. 40 0 3
. 3 00 3
. 3 0 0 1 .0 00 1
. 00 0 1 .0 0 0 1. 0 00 1
. 00 0 1. 0 00 1
. 00 0 1
. 00 0 l. 0 00 1 .00 0 1
. 00 0 1
. 00 0 1
. 0 0 0 1
. 0 0 0 1. 0 0 0 1 .0 0 0 1 .00 0 1
. 0 0 0 1
. 0 00 1
. 0 0 0 1
. 0 00 l. 000 l. 0 0 0 1
. 0 00 l. 0 00 1
. 0 00 l. 0 00 l. 0 00 l. 0 00 l. 0 00 1. 00 0 1. 00 0 l. 00 0 l. 00 0 1.00 0 1.00 0 l. 00 0 l. 000 1. 00 0 1. 00 0 1
. 00 0 1. 00 0 1. 0 00 l. 0 00 l. 000 Com m

e n t
O

F768 9 O

F7 68 9 OF7 6 S9 OF7 6 8 9 OF768 9 OF7 6 89 OF76 89 O

F7689 OF7 6S9 OF7 68 9 OF7 6S 9 O

F7 6 S9 OF76S9 OF7689 OF7 689 OF7 689 OF7689 OF7 6 8 9 O

F76 8 9 OF76S9 O

F 7 689 OF7 6 89 O

F76 89 O

F76S9 O

F 7 6S9 O

F 7 6 8 9 O

F76 8 9 OF 7 6 S9 OF 76S9 OF 76S9 OF 76S9 OF7 6S9 OF7 6 S 9 OF7 6 89 O

F76 89 O

F76 S 9 O

F76S9 OF 76S9 OF7 6 S9 O

F 7 6 8 9 O

F76 8 9Kasugamycin Dietary E xposure and Risk Assessment PC Co de 23000 I DP Barcode D 4 15989 

### Attachment 2. Summary of the Chronic D ietary Exp osure and Risk Est imates for Kasugamycin. US EPA DEEM

- FC ID C hr on i c analysis f o r KAS U GAMYCI N Resi du e f i le nam e : C : \Docum ents and Set ting s\wdrew\My Docu me nts\ Ka s u gamy ci nD EEM 1 10813Input.R08 Ver. 3. 16 , 03

- 08

- d NHANES 2003

- 2008 2

- da y Adjustmen t f a c t or # 2 NOT u se d. Analys i s Date 11- 08

- 20 1 3/08:04 : 33 R esidue file date d: 1 1

- 08

- 2 013/08:0 1 :45 Reference dose (RfD, Chronic) 

### =
. 1 1 m g/kg bw/day Total exposure b y popula ti on subgroup
Total Exposure Population

S u bgroup To t al 

### us Population Hi spani c Non

- Hi sp - W hite Non

- Hisp

- Black No n- Hisp

- O ther N

ursing Infan t s N

on-Nursing I nf ants Fe m a l e 13+ PREG Children 1- 6 Ch ildren 7

- 12 Male 1 3

- 19 Fema l e 13

- 19/NP Male 20 + Fe m ale 20+/NP Sen i ors 55+ A ll Infants Female 13-50 Ch il dren 1- 2 Ch il d ren 3

- 5 Ch il d re n 6

- 12 Yo uth 1 3

- 19 Adu l t s 2 0

- 4 9 Adults 50

- 99 Female 13

- 49 mg/ k g body wt /day 0 .0 00 526 0 .0 00733 0
. 000475 0.000557 0.000592 0. 001128 0.002243 0. 000446 0. 0 02400 0.0007 40 0
. 000365 0.000364 0 .0 00285 0
. 00027 4 0.000 264 0.001899 0.00029 9 0
. 003385 0.002015 0. 0008 40 0. 0 0036 7 0
. 000295 0
. 000264 0
. 000299



### Pag e 9 of9 Percen t of Rf d 0. 5% 0
. 7% 0 . 4 % 0 .5 % 0
. 5% 1
. 0% 2
. 0% 0 .4 % 2 .2% 0.7% 0.3% 0
. 3% 0.3% 0.2% 0
. 2% 1. 7% 0
. 3% 3
. 1% 1. 8% 0.8% 0.3% 0.3% 0.2% 0.3%