# Patent

## Title
Method of detecting at least one mechanism of resistance to cephalosporins by mass spectrometry

## Abstract

The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.

## Background
This application is a divisional application of U.S. patent application Ser. No. 14/111,118, filed Dec. 23, 2013, which is in turn a U.S. National Stage of International Application No. PCT/EP2012/057322, filed Apr. 20, 2012, which claims priority from U.S. Provisional Application No. 61/477,907, filed Apr. 21, 2011. The disclosure of the prior applications is hereby incorporated by reference herein in their entirety.


The present invention relates to the field of microbiology. More precisely, the invention relates to the detection of at least one mechanism of resistance to cephalosporins of at least one microorganism from a sample by using mass spectrometry.
Since Pasteur's discovery of microbes, microorganisms have been studied by microscopy and biochemical analyses. These conventional methods are often long and tedious, and analytical alternatives were sought very early on. This is why the analysis of bacteria by mass spectrometry was initiated from 1975 by J. Anhalt and C. Fenselau [1].
This preliminary work was followed by the study of fatty acids from the wall of the microorganisms using gas chromatography combined with mass spectrometry (GC-MS) [2]. This method was popularised under the English term FAME, standing for Fatty Acid Methyl Ester. It currently constitutes a reference method for taxonomic studies. However, its use remains limited to certain specialised laboratories dealing with the treatment of the sample by saponification, hydrolysis and derivation. In 1996, the works by M. Claydon et al. [3] as well as by T. Krishnamurthy and P.
Ross [4] demonstrated the possibility of identifying different bacterial species with a MALDI-TOF mass spectrometer (English acronym for Matrix Assisted Laser Desorption Ionization—Time Of Flight). The analysis combines the acquisition of a mass spectrum and the interpretation of expert software. It is extremely simple and can be carried out in a few minutes. However it has only been making it into medical analysis laboratories fairly recently [5]. Its clinical use is currently limited to the identification of bacteria and yeast species. It is not routinely used to identify resistances to antimicrobials.
Yet the identification of resistances to antimicrobials such as antibiotics is an essential element in ensuring optimal patient care.
Other mass spectrometry methods, particularly in tandem, have been proposed to meet these needs. By way of example, it is possible to cite the work of C. Fenselau et al. for identifying β-Lactamase with a quadripole-TOF (Q-TOF) [6].
However these research results are not applicable to routine clinical use. They were obtained with research instruments requiring highly qualified personnel. The analysis times, often greater than one hour per sample, are incompatible with the workload of a microbiological analysis laboratory.
More recently, S. Hofstadler et al. [7] proposed a method combining a microbial genome amplification by PCR to a detection of the PCR products by electrospray-TOF (ESI-TOF). This method is now fully automated [8]. However, it requires a PCR amplification with the flaws inherent in molecular biology, namely extraction yield, cost of the probes, etc.
In this context, the objective of the present invention is to propose a method of detecting mechanisms of resistance to cephalosporins which makes it possible to overcome the disadvantages of the prior art methods, namely providing an inexpensive method, without reagents specific to each species, particularly compared to molecular biology methods, which gives a result in a short amount of time, less than one hour, and which can be used in routine clinical work, without requiring highly qualified personnel.
To this end, the invention proposes a new method of detecting, by mass spectrometry, at least one mechanism of resistance to at least one antimicrobial of at least one microorganism from a sample, characterised in that the antimicrobial is a cephalosporin and in that proteins and/or peptides are detected as markers of said mechanism of resistance to at least one cephalosporin-class antibiotic.
Advantageously, markers of resistance to several different antimicrobials can be detected simultaneously.
As indicated in application PCT/FR2010/052181, markers of type and/or virulence of said microorganisms can be detected in the same way by mass spectrometry prior to or at the same time as the detection of the resistance mechanism markers.
Markers of resistance to at least one cephalosporin-class antimicrobial is understood to mean molecules of protein origin which are characteristic of said properties.
Cephalosporins are antibiotics belonging to the beta-lactam family. They are usually classified in several subclasses:

    
    
        first-generation cephalosporins, such as cefazolin, cephalothin, cefaclor, cephalexin, which are broken down by the beta-lactamases of groups 1 and 2b, 2br, 2be, 2ber
        second-generation cephalosporins, such as cefamandole, cefpodoxime, cefuroxime, which are broken down by the beta-lactamases of groups 1, 2be, 2ber
        third-generation cephalosporins, such as cefotaxime, ceftazidime, ceftriaxone, cefixime, which are broken down by the beta-lactamases of groups 1, 2be, 2ber, even though they are more stable than the first-generation and second-generation cephalosporins
        fourth-generation cephalosporins, such as cefepime and cefpirome, which are broken down by the beta-lactamases of groups 2be and 2ber
        cephalosporins exhibiting anti-MRSA activity such as ceftaroline and ceftobiprole, which are broken down by the beta-lactamases of groups 2be and 2ber
        cephamycins, such as cefoxitin, cefotetan, cefmetazole, which are broken down by the beta-lactamases of group 1
    
    


Determination of the resistance to at least one antimicrobial is understood to mean determining the susceptibility of a microorganism to being destroyed by an antimicrobial. The proteins involved in the resistance mechanisms will differ depending on the family and the species.
The nomenclature of the beta-lactamases, beta-lactam-resistant bacterial enzymes, is not standardised. They are either classified in four molecular classes (A to D) on the basis of their primary structure, or in functional groups on the basis of the target substrates and their resistance to inhibitors (for an overview, see [9] Bush and Jacoby, Antimicrobial Agents and Chemotherapy, 2010; 54 (3): 969-976). For molecular classification, sequencing techniques have made more precise classification possible: for example, 183 variants of the TEM protein have been described (labelled TEM-i, with i being between 1 and 183). For the functional classification, Bush and Jacoby (supra) have proposed new functional subgroups:

    
    
        the group 1 enzymes are cephalosporinases belonging to the molecular class C. ACC, ACT, MIR, MOX, DHA, CMY and FOX are plasmid-borne enzymes, belonging to this subgroup.
        the group 2 enzymes belong to molecular classes A and D. This group is itself subdivided into subgroups: 2a, 2b, 2be, 2br, 2ber, 2c, 2ce, 2d, 2de, 2df, 2f, etc. CTX-M (2be), SHV (2b, 2be or 2br), PER (2be), VEB (2be) and TEM (2b, 2be, 2br or 2ber) are enzymes belonging to this group.
        
            The subgroup 2a corresponds to beta-lactamases which hydrolyse benzylpenicillin and penicillin derivatives, but which do not hydrolyse cephalosporins, carbapenems or monobactams.
            The subgroup 2b corresponds to broad-spectrum beta-lactamases which hydrolyse first-generation penicillins and cephalosporins such as cephaloridine and cephalothin, and which are inhibited by clavulanic acid, sulfobactam, or tazobactam. The variants TEM-1, TEM-2 and SHV-1 belong to this subgroup.
            
                The subgroup 2b corresponds to extended-spectrum beta-lactamases (ESBL) which are also inhibited by clavulanic acid, sulfobactam, or tazobactam. These enzymes, in addition to the properties of subgroup 2b, hydrolyse at least one oxyimino-beta-lactam such as cefotaxime or ceftazidime, and monobactams such as aztreonam. This subgroup contains numerous variants of TEM and SHV, variants of PER and VEB, as well as CTX-M, BEL-1, BES-1, SFO-1, TAL-1 and TAL-2.
                The subgroup 2br corresponds to beta-lactamases from the subgroup 2b which are insensitive to inhibition by clavulanic acid, sulfobactam or tazobactam. This subgroup contains variants of the enzymes TEM and SHV.
                The subgroup 2ber corresponds to beta-lactamases from the subgroup 2be which are insensitive to inhibition by clavulanic acid, sulfobactam or tazobactam. This subgroup contains TEM variants.
            
            
            The subgroup 2ce is characterised by its ability to hydrolyse carbenicillin or ticarcillin, as well as cefepime and cefpirome. CARB-10 is part of this subgroup.
            The subgroup 2d includes the OXA beta-lactamases capable of hydrolysing cloxacillin or oxacillin. The OXAs (or oxacillinases) correspond to class-D beta-lactamases, according to their primary sequence, and they can confer resistances to cephalosporins or to cephalosporins and to carbapenems (Poirel et al., 2010, Antimicrobio. Agents Chemother., 54:24-38).
            
                The subgroup 2de includes OXAs having an extended spectrum extended to oxy-imino-beta-lactams, but not to carbapenems.
                The subgroup 2df includes OXAs having a spectrum extended to carbapenems.
            
            
            The subgroup 2e corresponds to extended-spectrum cephalosporinases, which are inhibited by clavulanic acid or tazobactam.
            The subgroup 2f corresponds to carbapenemases such as SME, KPC or certain variants of GES. The first GES beta-lactamase was isolated in 1998 in French Guiana (Poirel et al., 2000, Antimicrobio. Agents Chemother., 43:622-632). This enzyme (GES-1) conferred an ESBL resistance (subgroup 2be). The second isolate from a bacterium bearing a GES beta-lactamase was achieved in 2000 in South Africa (Poirel et al., 2001, Antimicrobio. Agents Chemother., 45: 2598-2603). This enzyme (GES-2) conferred a resistance to cephalosporins and to carbapenems such as imipenem (subgroup 2f).
        
        
        The group 3 enzymes are metallo-beta-lactamases known for hydrolysing carbapenem-class antibiotics. The enzymes IMP, VIM, CAU, GOB or FEZ are part of this group.
    
    


The method of the invention can be employed to detect mechanisms of resistance to cephalosporins in bacteria. Thus, for example, as bacteria in which it is possible to seek a mechanism of resistance to cephalosporins according to the method of the invention, non-exhaustive mention may be made of:

    
    
        the Enterobacteriaceae, using group 1 and group 2 proteins and peptides as a resistance marker;
        non-fermenting bacteria (Pseudomonas aeruginosa, Acinetobacter baumannii)
        etc.
    
    


It should further be noted that the strains known to be resistant to carbapenems are also resistant to cephalosporins and to penicillins. Therefore, a method of detecting a mechanism of resistance to carbapenems also makes it possible to detect a mechanism of resistance to cephalosporins and to penicillins.
The sample on which the method of the invention can be employed is any sample susceptible of containing a target microorganism. The sample can be of biological origin, either animal, vegetable or human. In this case it may correspond to a specimen of biological fluid (whole blood, serum, plasma, urine, cerebrospinal fluid, organic secretion, for example), a tissue specimen or isolated cells. This specimen can be used such as it is insofar as the markers of mechanisms of bacterial resistance to beta-lactams are available in the sample tested, or it can, prior to the analysis, undergo preparation by enrichment, extraction, concentration, purification, culturing, in accordance with methods known to the person skilled in the art.
The sample can be of industrial origin, or, according to a non-exhaustive list, can be an air specimen, a water specimen, a surface specimen, a part or a manufactured product, or a food product. Amongst the food samples, non-exhaustive mention can be made of a sample of a dairy product (yogurts, cheeses), of meat, of fish, of egg, of fruit, of vegetable, of water, of a beverage (milk, fruit juice, soda, etc.). These food samples can also come from sauces or ready meals. Finally, a food sample can come from an animal feed, such as animal meals.
Upstream of the detection by mass spectrometry, the sample to be analysed is preferably pre-treated to produce peptides from the entirety of the proteins present in the sample to fragment these proteins into peptides, for example by digestion with a proteolytic enzyme (protease), or by the action of a chemical reagent. In fact, the cleaving of the protein can be performed by a physico-chemical treatment, by a biological treatment or by a combination of the two treatments. Amongst the useable treatments, mention can be made of treatment by hydroxyl radicals, in particular with H2O2. Treatment by hydroxyl radicals results in a cutting of the peptide bonds which takes place randomly on any of the protein's peptide bonds. The hydroxyl radical concentration determines the number of cleavages performed, and therefore the length of the peptide fragments obtained. Other chemical treatments can also be used such as, for example, cyanogen bromide (CNBr) treatment which specifically splits the peptide bonds at the carboxyl group of the methionyl residues. It is also possible to perform partial acid cleaving at the aspartyl residues by heating a solution of proteins in trifluoroacetic acid to 1000° C.
Treatment of the proteins by enzymatic digestion is nevertheless preferred over physico-chemical treatment because it preserves more of the structure of the protein, and is easier to control. “Enzymatic digestion” is understood to mean the single or combined action of one or more enzymes under appropriate reaction conditions. The enzymes carrying out the proteolysis, which are called proteases, cut the proteins at specific locations. Each protease generally recognises a sequence of amino acids within which it always makes the same cut. Certain proteases recognise a single amino acid or a sequence of two amino acids between which they perform a cleavage, whereas other proteases only recognise longer sequences. These proteases can be endoproteases or exoproteases. Amongst the known proteases, mention may be made of the following as described in WO2005/098071:

    
    
        specific enzymes such as trypsin which splits the peptide bond at the carboxyl group of the Arg and Lys residues, endolysin which cleaves the peptide bond of the —CO group of the lysines, chymotrypsin which hydrolyses the peptide bond at the carboxylic group of the aromatic residues (Phe, Tyr and Trp), pepsin which makes a cut at the NH2 group of the aromatic residues (Phe, Tyr and Trp), the protease V8 from the V8 strain of Staphylococcus aureus which cleaves the peptide bond at the carboxylic group of the Glu residue;
        the non-specific enzymes such as thermolysin from the bacteria Bacillus thermoproteolyticus which hydrolyses the peptide bond of the NH2 group of hydrophobic amino acids (Xaa-The, Xaa-Ile, Xaa-Phe), subtilisin and pronase which are bacterial proteases which hydrolyse practically all the bonds and can transform the proteins into oligopeptides under controlled reaction conditions (enzyme concentration and duration of reaction).
    
    


Several proteases may be used simultaneously, if their modes of action are compatible, or they may be used successively. Within the framework of the invention, the digestion of the sample is preferably performed by the action of a protease enzyme, for example trypsin.
The generation of peptides using a chemical reagent or a protease can be obtained by means of a simple reaction in solution. It can also be performed with a microwave oven [10], or under pressure [11], or even with an ultrasound device [12]. In these three latter cases, the protocol will be much faster.
Amongst the peptides thus obtained, the peptides specific to the protein are referred to as proteotypic peptides. It is these which will be assayed by mass spectrometry. According to the invention, the markers of the mechanisms of bacterial resistance to cephalosporins are proteins from the bacterium in which the mechanisms of resistance to cephalosporins are to be sought. In particular, said proteins are digested into peptides, preferably by an enzyme, and more preferably by trypsin. Similarly, the sample containing protein markers characterising mechanisms of bacterial resistance to cephalosporins can also be pre-treated for the purposes of purification. This purification pretreatment can be employed before or after the peptide production step as described above.
The sample purification pretreatment is widely known to the person skilled in the art and may in particular employ the techniques of centrifugation, filtration, electrophoresis or chromatography. These separating techniques can be used alone or in combination with one another to obtain a multidimensional separation. For example, multidimensional chromatography can be used by combining separation by ion exchange chromatography with reversed-phase chromatography, as described by T. Fortin et al. [13], or H. Keshishian et al. [14]. In these publications, the chromatography medium can be in a column or in a cartridge (solid-phase extraction).
The electrophoretic or chromatographic fraction (or the retention time in monodimensional or multidimensional chromatography) of the proteotypic peptides is characteristic of each peptide, and employing these techniques therefore makes it possible to select the proteotypic peptide or peptides to be assayed. Such a fractionation of the produced peptides makes it possible to increase the specificity of the subsequent assay by mass spectrometry.
An alternative to the electrophoresis or chromatography techniques for the fractionation of the peptides consists in specifically purifying the N-glycopeptides ([15] and patent application WO 2008/066629). However, such a purification only makes it possible to quantify the peptides which have undergone an N-glycosylation post-translational modification. Not all proteins are glycosylated though, which therefore limits its use.
The mass spectrometry to be employed in the method of the invention is widely known to the person skilled in the art as a powerful tool for analysing and detecting different types of molecules. Generally, any type of molecule able to be ionised can be detected according to its molecular mass with the aid of a mass spectrometer. According to the nature of the molecule to be detected, whether of protein or metabolic origin, certain mass spectrometry technologies can be more suitable. Nevertheless, whatever mass spectrometry method is used for the detection, this latter includes a step of ionising the target molecule into so-called molecular ions, in the present case a step of ionising the characterising markers, and a step of separating the molecular ions obtained according to their mass.
All mass spectrometers therefore comprise:

    
    
        an ionising source intended to ionise the markers present in the sample to be analysed, i.e. to confer a positive or negative charge upon these markers;
        a mass analyser intended to separate the ionised markers, or molecular ions, according to their mass-to-charge ratio (m/z);
        a detector intended to measure the signal produced either directly by the molecular ions, or by ions produced from molecular ions as detailed hereafter.
    
    


The ionisation step necessary for employing mass spectrometry can be performed via any method known to the person skilled in the art. The ionising source makes it possible to transform the molecules to be assayed into a gaseous and ionised state. An ionising source can be used either in positive mode to study the positive ions, or in negative mode to study the negative ions. Several types of sources exist and will be used depending on the result sought and the molecules analysed. In particular, mention may be made of:

    
    
        electron ionisation (EI), chemical ionisation (CI) and desorption chemical ionisation (DCI)
        fast atom bombardment (FAB), metastable atom bombardment (MAB) or ion bombardment (SIMS, LSIMS)
        inductively coupled plasma (ICP)
        atmospheric-pressure chemical ionisation (APCI) and atmospheric-pressure photoionisation (APPI)
        electronebulisation or electrospray (ESI)
        matrix-assisted laser desorption/ionisation (MALDI), surface-activated laser desorption/ionisation (SELDI) or desorption/ionisation on silicon (DIOS)
        ionisation/desorption by interaction with metastable species (DART)
    
    


In particular, ionisation can be employed as follows: the sample containing the target molecules is introduced into an ionisation source, where the molecules are ionised in gaseous state and thus transformed into molecular ions which correspond to the initial molecules. An electrospray ionisation (ESI) source makes it possible to ionise a molecule by making it pass from a liquid state into a gaseous state. The molecular ions obtained therefore correspond to the molecules present in liquid state, with, in positive mode, one, two, or even three or more additional protons and therefore carry one, two, or even three or more charges. For example, when the target molecule is a protein, an ionisation of the proteotypic peptides obtained after fractionation of the target protein, by means of an electrospray source functioning in positive mode, leads to polypeptide ions in gaseous state, with one, two, or even three or more additional protons and which therefore carry one, two, or even three or more charges, and makes it possible to move from a liquid state to a gaseous state [16]. This type of source is particularly well suited when the target molecules or proteotypic peptides obtained are separated beforehand by reversed-phase liquid chromatography. Nevertheless, the ionisation yield of the molecules present in the sample may vary depending on the concentration and the nature of the different species present. This phenomenon leads to a matrix effect well known to the person skilled in the art.
A MALDI ionisation source will allow ionisation of the molecules from a solid-state sample.
The mass analyser in which the step of separating the ionised markers according to their mass-to-charge ratio (m/z) is performed is any mass analyser known to the person skilled in the art. Mention can be made of low-resolution analysers, quadripole or quadrupole (Q), 3D ion trap (IT) or linear ion trap (LIT), also called ion trap, and high-resolution analysers which make it possible to measure the exact mass of the analytes and which in particular use the magnetic sector linked to an electric sector, the time of flight (TOF), Fourier transform ion cyclotron resonance (FT-ICR), orbitrap.
The separation of the molecular ions depending upon their m/z ratio can be employed just once (single mass spectrometry or MS), or several successive MS separations can be conducted. When two successive MS separations are carried out, the analysis is called MS/MS or MS2. When three successive MS separations are carried out, the analysis is called MS/MS/MS or MS3, and more generally, when n successive MS separations are carried out, the analysis is called MS.
Amongst the techniques which employ several successive separations, SRM (Selected Reaction Monitoring) mode when detecting or assaying a single target molecule, or MRM (Multiple Reaction Monitoring) mode when detecting or assaying several target molecules are particular uses of MS2 separation. Similarly the MRM3 mode is a particular use of MS/MS/MS separation. This is referred to as targeted mass spectrometry.
In the case of a detection in single MS mode, it is the mass-to-charge ratio of the molecular ions obtained which is correlated to the target molecule to be detected.
In the case of detection in MS/MS mode, essentially two steps are added, compared to an MS assay, which are:

    
    
        a fragmentation of the molecular ions, then called precursor ions, to give ions called 1st generation fragment ions, and
        a separation of the ions called 1st generation fragment ions according to their mass (m/z)2, the ratio (m/z)1 corresponding to the ratio (m/z) of the precursor ions.
    
    


It is therefore the mass-to-charge ratio of the 1st generation fragment ions thus obtained which is correlated to the target molecule to be detected. First-generation fragment ion is understood to be an ion derived from the precursor ion, following a fragmentation step and of which the mass-to-charge ratio m/z is different from the precursor ion.
The (m/z)1 and (m/z)2 pairs are called transitions and are representative of the characteristic ions to be detected.
The choice of the characteristic ions which are detected to be correlated to the target molecule is made by the person skilled in the art in accordance with the standard methods. Their selection will advantageously lead to the most sensitive, specific and robust assays possible, in terms of reproducibility and reliability. In the methods developed for the selection of proteotypic peptides (m/z)1, and of the first-generation fragment (m/z)2, the choice is essentially based on the intensity of the response. For more details, it is possible to refer to V. Fusaro et al. [17]. Commercially available software, such as the MIDAS and MRM Pilot software from Applied Biosystems or MRMaid [18] can be used by the person skilled in the art to allow him to predict all the possible transition pairs. He can also make use of a database called PeptideAtlas constructed by F Desiere et al. [19] to compile all of the MRM transitions of peptides described by the scientific community. This database PeptideAtlas is freely available on the internet. For non-protein molecules, it is also possible to use databases, such as, for example, the one accessible through the Cliquid software from the company Applied Biosystems (United States of America).
An alternative approach to selecting the proteotypic peptides (m/z)1 and (m/z)2 consists in using MS/MS fragmentation spectra obtained during other work. This work can be, for example, the phases of biomarker discovery and identification by proteomic analysis. This approach was proposed by Thermo Scientific during user conferences [18]. It makes it possible to generate a list of candidate transitions from the peptides identified through testing by the SIEVE (Thermo Scientific) software. Certain criteria were detailed by J. Mead et al. [18] for the choice of the ions (m/z)1 and (m/z)2 and are detailed hereafter:

    
    
        peptides with internal cleavage sites, i.e. with internal Lysine or Arginine, must be avoided, unless the Lysine or Arginine is followed by Proline,
        peptides with Aspargine or Glutamine must be avoided because they may deaminate,
        peptides with Glutamine or Glutamic Acid at the N-terminal must be avoided because they may cyclise spontaneously,
        peptides with Methionine must be avoided because they may be oxidised,
        peptides with Cysteine must be avoided because they may be non-reproducibly modified during a potential step of denaturation, reduction and blocking of the thiol functions,
        peptides with Proline may be considered to be favourable because they generally produce intense fragments in MS/MS with a very strong single peak. However, a very strong single fragment does not make it possible to validate the identity of the transition in a complex mixture. Indeed, only the simultaneous presence of several characteristic fragments makes it possible to verify that the precursor ion sought has actually been detected,
        the peptides having a Proline adjacent to the C-terminal (Position n−1) or in second position relative to the C-terminal (position n−2) should be avoided because, in this case, the size of the first-generation peptide fragment is generally considered to be too small to be sufficiently specific,
        the selection of fragments having a mass greater than the precursor should be given preference in order to promote specificity. To this end, it is necessary to select a dicharged precursor ion and select the most intense first-generation ion fragment having a mass greater than the precursor, i.e. a monocharged first-generation fragment ion.
    
    


The fragmentation of the selected precursor ions is performed in a fragmentation cell such as the triple quadripole model [20], ion trap model [21], or time-of-flight (TOF) model [22], which also make it possible to separate ions. The fragmentation or fragmentations will be conventionally performed by collision with an inert gas such as argon or nitrogen, within an electrical field, by photo-excitation or photo-dissociation using an intense light source, collision with electrons or radical species, by applying a potential difference, for example in a time-of-flight tube, or by any other activation mode. The characteristics of the electrical field determine the intensity and nature of the fragmentation. Thus, the electrical field applied in the presence of an inert gas, for example in a quadripole, determines the collision energy provided to the ions. This collision energy will be optimised, by the person skilled in the art, to increase the sensitivity of the transition to be assayed. By way of example, it is possible to vary the collision energy between 5 and 180 e−V in q2 in an AB SCIEX QTRAP® 5500 mass spectrometer from the company Applied Biosystems (Foster City, United States of America). Similarly, the duration of the collision step and the excitation energy within, for example, an ion trap will be optimised by the person skilled in the art to lead to the most sensitive assay. By way of example, it is possible to vary this duration, called excitation time, between 0.010 and 50 ms and the excitation energy between 0 and 1 (arbitrary unit) in Q3 in an AB SCIEX QTRAP® 5500 mass spectrometer by the company Applied Biosystems.
Finally, the detection of the selected characteristic ions takes place in the conventional manner, particularly by means of a detector and a processing system. The detector collects the ions and produces an electrical signal whose intensity depends on the amount of ions collected. The signal obtained is then amplified such that it can be processed by computer. A computer data processing assembly makes it possible to transform the information received by the mass spectrum detector.
The principle of the SRM mode, or even of the MRM mode, is to specifically select a precursor ion, fragment it, and then specifically select one of its fragment ions. For such applications, triple quadripole or hybrid triple quadripole/ion trap devices are generally used.
In the case of a triple quadripole device (Q1q2Q3) used in MS2 mode, with a view to assaying or detecting a target protein, the first quadripole (Q1) makes it possible to filter the molecular ions corresponding to the proteotypic peptides characteristic of the protein to be assayed and obtained during an earlier digestion step, depending on their mass-to-charge ratio (m/z). Only the peptides having the mass-to-charge ratio of the proteotypic peptide sought, which ratio is called (m/z)1, are transmitted into the second quadripole (q2) and act as precursor ions for the subsequent fragmentation. The analyser q2 can fragment the peptides of mass-to-charge ratio (m/z)1 into first-generation fragment ions. Fragmentation is generally obtained through collision of the precursor peptides with an inert gas, such as nitrogen or argon in q2. The first-generation fragment ions are transmitted into a third quadripole (Q3) which filters the first-generation fragment ions depending on a specific mass-to-charge ratio, called (m/z)2. Only the first-generation fragment ions having the mass-to-charge ratio of a fragment characteristic of the sought proteotypic peptide (m/z)2 are transmitted into the detector in order to be detected, or even quantified.
This mode of operation exhibits a double selectivity, with regard to the selection of the precursor ion on the one hand, and the selection of the first-generation fragment ion on the other hand. Mass spectrometry in SRM or MRM mode is therefore advantageous for quantification.
When the mass spectrometry employed in the method according to invention is tandem mass spectrometry (MS2, MS3, MS4 or MS5), several mass analysers can be linked to one another. For example, a first analyser separates the ions, a collision cell makes it possible to fragment the ions, and a second analyser separates the fragment ions. Certain analysers, such as the ion traps or the FT-ICR, constitute several analysers in one and make it possible to fragment the ions and analyse the fragments directly.
According to preferred embodiments of the invention, the method of the invention comprises one or more of the following characteristics:

    
    
        the mass spectrometry employed for the properties of potential resistance to at least one antimicrobial is MS/MS spectrometry, which has the advantage of producing a fragment which is specific to the molecule to be detected or quantified, and thus of providing great specificity to the assaying method;
        the MS/MS spectrometry is MRM which has the advantage of using an analysis cycle time in the mass spectrometer of several tens of milliseconds, which makes it possible to detect or quantify, with a high degree of sensitivity, a large number of different molecules in a multiplexed manner;
        where applicable, the determination of the type properties and of the virulence factor is performed in the same mass spectrometry apparatus as the determination of the markers of resistance to at least one antimicrobial, preferably simultaneously, which has the advantage of reducing the analysis time and the cost of the instrument, which also facilitates the processing and the yielding of the results.
    
    


In addition to determining the resistance to an antibiotic, it is necessary to identify the microorganism or microorganisms present in the sample to be tested.
The methods of identifying microorganisms are widely known to the person skilled in the art, as described for example by Murray P. R. et al. in Manual of Clinical Microbiology, 2007, 9th edition, and especially in Vol. I, Section III, chapters 15 and 16 for bacteria and yeasts, Vol. II, Section VI, chapter 82 for viruses, and Vol. II, Section X, chapter 135 for protozoa. As an example of conventional identification methods, mention can be made of the determination of the biological profile, by using the Vitek 2 (bioMérieux) identification cards, for example, or even by using molecular biology techniques with identification criteria based on the study of the presence of certain genes, and on the study of their sequence.
Identification can be performed directly from the sample in which the identification is made, or the microorganisms contained in the sample can be cultured using methods well known to the person skilled in the art with optimal culture media and culturing conditions tailored to the species of microorganisms to be sought, as described by Murray P. R. et al. in Manual of Clinical Microbiology, 2007, 9th edition, Vol. I, Section III, chapter 14, and in particular in Vol. I, Section IV, chapter 21 for bacteria, and Vol. II, Section VI, chapter 81 for viruses, Vol. II, Section VIII, chapter 117 for yeasts, and Vol. II, Section X, chapter 134 for protozoa.
Thus, generally, in the case of an identification using a biochemical method of a bacterium in a specimen, it is first necessary to obtain it in a pure culture, for example after seeding on agar. Molecular biology (PCR) can in certain cases be applied directly to the sample to be analysed.
Instead of cultivating the microorganisms, they can be concentrated by capture directly in the sample by means of active surfaces. Such a method was described by W.-J. Chen et al. [11] who captured different bacterial species with the aid of magnetic beads with an Fe3O4/TiO2-activated surface. Capture by other means is also possible, such as a capture by lectins [23], or by antibodies [24], or by Vancomycin [25]. The capture makes it possible to concentrate the microorganisms and thus to reduce or even eliminate the culture step. This results in a considerable timesaving.
The identification may also be performed by mass spectrometry, in accordance with the techniques described previously, preferably by MS, by MS/MS, or even by MS followed by MS/MS spectrometry, which constitutes one embodiment of the invention. In this case too, the sample can be subjected to a culture step beforehand, such as seeding on agar.
The use of an MS identification method is advantageous in that it may be carried out in a few minutes, and in that it requires a mass spectrometer with a single analyser, i.e. a less complex instrument than a tandem mass spectrometer used in MS/MS.
The use of a method of identification by MS followed by MS/MS spectrometry is also advantageous. It makes it possible to check the identity of the ions observed by MS, which increases the specificity of the analysis.
The use of an MRM-type MS/MS identification method has the advantage of being more sensitive and simpler than the conventional MS followed by MS/MS approaches. This method requires neither a high-performance software to process the information between the acquisition of the MS spectrum and of the MS/MS spectrum, nor a change in the setting of the machine parameters for linking up MS then MS/MS spectra.
The method of identification by MS may be employed with an electrospray source on a raw sample, as described by S. Vaidyanathan et al. [26] or by R. Everley et al. [27] after chromatographic separation. Different m/z ranges thus make it possible to identify the microorganisms. S. Vaidyanathan et al. used a window of between 200 and 2000 Th, and R. Everley et al. used a window of between 620 and 2450 Th. The mass spectra may also be deconvoluted to access the mass of the proteins independently of their charge state. R. Everley et al. therefore used masses of between about 5,000 and 50,000 Da. Alternatively, the method of identification by MS can also be employed with the aid of a MALDI-TOF, as described by Claydon et al. [3] and T. Krishnamurthy and P. Ross [4]. The analysis combines acquisition of a mass spectrum and interpretation of expert software. It is extremely simple and can be carried out in a few minutes. This method of identification is currently becoming more widespread in medical analysis laboratories [28].
The identification of bacteria by MS followed by MS/MS via their proteins present in the sample has been applied widely by a number of teams. By way of example, mention can be made of the recent work of Manes N. et al. [29], who studied the peptidome of Salmonella enterica, or the work of R. Nandakumar et al. [30] or of L. Hernychova et al. [31] who have studied the proteome of bacteria after digestion of the proteins with trypsin. The conventional approach consists in i) acquiring an MS spectrum, ii) successively selecting each precursor ion observed on the MS spectrum with an intense signal, iii) successively fragmenting each precursor ion and acquiring its MS/MS spectrum, iv) interrogating protein databases such as SWISS-PROT or NCBI, through software such as Mascot (Matrix Science, London, United Kingdom) or SEQUEST (Thermo Scientific, Waltham, United States of America), to identify the peptide which has a strong probability of matching the MS/MS spectrum observed. This method may lead to the identification of a microorganism if a protein or a peptide characteristic of the species is identified.
One of the advantages of the use of the mass spectrometry lies in that it is particularly useful for quantifying molecules, in the present case the markers of the mechanisms of bacterial resistance to beta-lactams. To this end, the current intensity detected is used, which is proportional to the quantity of target molecule. The current intensity thus measured may serve as a quantitative measurement making it possible to determine the quantity of target molecule present, which is characterised by its expression in International System (SI) mol/m3 or kg/m3 units, or by multiples or sub-multiples of these units, or by the usual derivatives of the SI units, including multiples or sub-multiples thereof. As a non-limiting example, the units such as ng/ml or fmol/l are units characterising a quantitative measurement.
A calibration is nevertheless necessary in order to be able to correlate the measured area of the peak, which corresponds to the current intensity induced by the detected ions, to the quantity of target molecule to be assayed. For this purpose, the calibrations conventionally used in mass spectrometry may be employed, within the framework of the invention. MRM assays are conventionally calibrated with the aid of external standards or, preferably, with the aid of internal standards such as described by T. Fortin et al. [13]. If the target molecule is a proteotypic peptide which permits the assaying of a protein of interest, the correlation between the quantitative measurement and the quantity of target proteotypic peptide, and subsequently of protein of interest, is obtained by calibrating the measured signal relative to a standard signal for which the quantity to be assayed is known. The calibration may be performed using a calibration curve, for example obtained by successive injections of standard proteotypic peptide at different concentrations (external calibration), or preferably by internal calibration using a heavy peptide as an internal standard, for example in accordance with the AQUA, QconCAT or PSAQ methods detailed below. “Heavy peptide” is understood to mean a peptide corresponding to the proteotypic peptide, but in which one or more atoms of carbon 12 (12C) is (are) replaced by carbon 13 (13C), and/or one or more atoms of nitrogen 14 (14N) is (are) replaced by nitrogen 15 (15N).
The use of heavy peptides as internal standards (AQUA) was also proposed in US patent application 2004/0229283. The principle is to artificially synthesise proteotypic peptides with amino acids containing isotopes which are heavier than the usual natural isotopes. Such amino acids are obtained, for example, by replacing some of the atoms of carbon 12 (12C) with carbon 13 (13C), or by replacing some of the atoms of nitrogen 14 (14N) with nitrogen 15 (15N). The artificial peptide (AQUA) thus synthesised has strictly the same physicochemical properties as the natural peptide (with the exception of a higher mass). It is generally added, at a given concentration, to the sample, upstream of assaying by mass spectroscopy, for example between the treatment entailing the cleaving of the proteins in the sample of interest and the fractionation of the peptides obtained after the treatment step. Thus, the AQUA peptide is co-purified with the natural peptide to be assayed, during fractionation of the peptides. The two peptides are therefore injected simultaneously into the mass spectrometer, for assaying. They then undergo the same ionisation yield in the source. The comparison of the peak areas of the natural and AQUA peptides, whose concentration is known, makes it possible to calculate the concentration of the natural peptide and thus trace back the concentration of the protein to be assayed. A variation of the AQUA technique was proposed by J.-M. Pratt et al. [32] under the name QconCat. This variant is also described in patent application WO 2006/128492. It consists in concatenating various AQUA peptides and producing the artificial polypeptide in the form of a heavy recombinant protein. The recombinant protein is synthesised with amino acids comprising heavy isotopes. In this way, it is possible to obtain a standard to calibrate the simultaneous assay of several proteins at lower cost. The QconCAT standard is added from the start, upstream of the treatment entailing the cleaving of the proteins and prior to the steps of protein fractionation, denaturation, reduction and blocking of the protein thiol functions, if these are present. The QconCAT standard therefore undergoes the same treatment cycle entailing the cleaving of the proteins as the natural protein, which makes it possible to take account of the yield from the treatment step which entails the cleaving of the proteins. In fact, the treatment, particularly by digestion, of the natural protein may not be complete. In this case, the use of an AQUA standard would lead to underestimating the quantity of natural protein. For full assaying, it may therefore be important to take into account the yields from treatment which entails the cleaving of the proteins. However, V. Brun et al. [33] have shown that the QconQAT standards sometimes do not exactly reproduce the treatment yield, particularly by digestion of the natural protein, undoubtedly due to a three-dimensional conformation different from the QconCAT protein.
V. Brun et al. [33] then proposed the use of a method dubbed PSAQ, and described in patent application WO 2008/145763. In this case, the internal standard is a recombinant protein having the same sequence as the natural protein but synthesised with heavy amino acids. The synthesis is performed ex-vivo with heavy amino acids. This standard has strictly the same physicochemical properties as the natural protein (with the exception of a higher mass). It is added from the start, before the protein fractionation step, when the latter is present. It is therefore co-purified with the native protein, during the protein fractionation step. It exhibits the same treatment yield, particularly by digestion, as the native protein. The heavy peptide obtained after cleaving is also co-purified with the natural peptide, if a peptide fractionation step is performed. The two peptides are therefore injected simultaneously into the mass spectrometer, to be quantitatively assayed. They then undergo the same ionisation yield in the source. Comparison of the peak areas of the natural and the reference peptides in the PSAQ method make it possible to calculate the concentration of the protein to be assayed taking into account all of the steps of the assay method.
All of these techniques, namely AQUA, QconCAT or PSAQ or any other calibration technique, used in the mass spectrometry assays and in particular in MRM or MS assays, may be employed to carry out calibration, within the framework of the invention.
Preferably, the mass spectrometry used in the detection method according to the invention is MS/MS. More preferably, the mass spectrometry is MRM.
The method of the invention makes it possible to detect resistances to cephalosporin, characterised by the detection of at least one peptide as a resistance marker. Said resistance marker peptide preferably belongs to the proteins TEM, CMY, CTX-M, SHV, FOX, ACC, ACT, CARB, DHA, MIR, MOX, PER, VEB, OXA or GES.
In particular, the detection of a mechanism of resistance to cephalosporins induced by the expression of the TEM protein is characterised by the detection of at least one peptide belonging to the TEM protein and its different sequence variants SEQ ID No. 1 to SEQ ID No. 165 and SEQ ID No. 1836 to SEQ ID No. 1843.








SEQ ID No. 1:



MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 2:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 3:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 4:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 5:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 6:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 7:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 8:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 9:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 10:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 11:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 12:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 13:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 14:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 15:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 16:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 17:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 18:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 19:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 20:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLRNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 21:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGGSERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKH


 


SEQ ID No. 22:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 23:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 24:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 25:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 26:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 27:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 28:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


HADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 29:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 30:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 31:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 32:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 33:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 34:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 35:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 36:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDELNRQIAEIGASLIKHW


 


SEQ ID No. 37:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRREPELNEAIP


 


NDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 38:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 39:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSTGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 40:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGVRVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 41:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 42:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 43:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW


 


SEQ ID No. 44:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 45:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 46:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 47:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGGQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 48:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 49:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 50:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 51:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 52:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSLGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 53:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAEPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 54:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLRNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 55:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLDRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 56:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRIVIIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 57:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMGDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 58:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDPNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 59:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 60:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 61:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 62:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLDRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 63:


MSIQHFRVALIPFFAAFCIPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 64:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDELNRQIAEIGASLIKHW


 


SEQ ID No. 65:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASQQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 66:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 67:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 68:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSCGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 69:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRAIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 70:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 71:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMGDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 72:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 73:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRREPELNEAIP


 


NDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 74:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSGGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 75:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAVTMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 76:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAVTMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 77:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW


 


SEQ ID No. 78:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRCEPELNEAIP


 


NDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW


 


SEQ ID No. 79:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 80:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 81:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 82:


MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLHCWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 83:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTDELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 84:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMGDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 85:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTG


 


GMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNE


 


AIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAG


 


WFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIK


 


HW


 


SEQ ID No. 86:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDCWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 87:


MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 88:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 89:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 90:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGAKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 91:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLGRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 92:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIVEIGASLIKHW


 


SEQ ID No. 93:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 94:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDELNRQIAEIGASLIKHW


 


SEQ ID No. 95:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIVEIGASLIKHW


 


SEQ ID No. 96:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCNAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 97:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 98:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 99:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAELSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTSELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERSRQIAEIGASLIKHW


 


SEQ ID No. 100:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 101:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 102:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGADERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 103:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLRNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 104:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 105:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 106:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 107:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 108:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 109:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 110:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 111:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 112:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW


 


SEQ ID No. 113:


MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 114:


MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 115:


MSIQHFRVALIPFLAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSREPELNEAIP


 


NDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 116:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERETTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 117:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDNVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 118:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGEHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 119:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 120:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKPAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 121:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 122:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAV


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 123:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 124:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 125:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 126:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGGQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 127:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGRRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 128:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PIDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 129:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIEMDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 130:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVEDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 131:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGANERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 132:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDCWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 133:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDCWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 134:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLMRSALPAG


 


WFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIK


 


HW


 


SEQ ID No. 135:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLPD


 


GMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNE


 


AIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAG


 


WFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIK


 


HW


 


SEQ ID No. 136:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSVLPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 137:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATKLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 138:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGVRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 139:


MSIQHFRVALIPFFAAFCLPVFAHPDTLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 140:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGGSLIKHW


 


SEQ ID No. 141:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 142:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 143:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 144:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNIGDHVTRLDRWEPELNEAIP


 


NDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 145:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQSDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 146:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW


 


SEQ ID No. 147:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 148:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGM


 


TVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIP


 


NDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWF


 


IADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 149:


MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 150:


MSIQHFRVALIPFFAAFCLPVFAHPKTLVKVKDAENQLGARVGYIELDLNSGKILESF


 


RPEKRFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQSDVVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 151:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKLW


 


SEQ ID No. 152:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQVGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQTAEIGASLIKHW


 


SEQ ID No. 153:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 154:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVGELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 155:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSVLPAGW


 


FIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 156:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 157:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRGEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 158:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEICASLIKHW


 


SEQ ID No. 159:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 160:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEVDKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRIVIIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 161:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEVDKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERKRQIAEIGASLIKHW


 


SEQ ID No. 162:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEVDKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 163:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSVLPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 164:


MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAI


 


PNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 165:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGSTSGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGSQELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDEADTTMPAAMATTLRKLLTGELLTLASRQQLIDWMADKVAGPLLRSALPAGWFI


 


ADKSGARERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1836:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1837:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1838:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFR


 


PEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1839:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1840:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1841:


MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGGQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1842:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW


 


SEQ ID No. 1843:


MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESF


 


RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDG


 


MTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAI


 


PNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGW


 


FIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 166 to SEQ ID 261 and SEQ ID No. 1923 to SEQ ID 1928 as defined hereafter:













Peptide





SEQ ID

Position of the peptide in the TEM
Clinical


No.
Amino acid sequence
protein(s)
interest







SEQ ID
CEPELNEAIPNDER
163-176 for the protein of SEQ No. 78
2br


No. 166


 


SEQ ID
DAEDQLGAR
33-41 for the proteins of SEQ No. 1, 4,
TEM


No. 167

5, 6, 9, 10, 12, 14, 16, 18, 19, 23, 24, 25,




26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36,




37, 38, 39, 41, 43, 45, 46, 47, 48, 49, 50,




51, 52, 53, 55, 56, 60, 64, 65, 66, 68, 69,




70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,




81, 82, 83, 85, 86, 87, 88, 89, 90, 91, 93,




94, 95, 96, 97, 98, 99, 100, 101, 102, 103,




106, 107, 108, 109, 110, 112, 113, 114,




115, 116, 117, 118, 121, 122, 123, 125,




126, 127, 128, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




144, 145, 146, 147, 149, 151, 153, 154,




155, 156, 157, 158, 159, 160, 161, 162,




163, 1837, 1838, 1840, 1841, 1842, 1843,




1844


 


SEQ ID
DAEDQLGSTSGYIELDLNSGK
33-53 for the protein of SEQ No. 165
2be


No. 168


 


SEQ ID
DAEDQVGAR
33-41 for the protein of SEQ No. 152
2be


No. 169


 


SEQ ID
DAENQLGAR
33-41 for the protein of SEQ No. 150
TEM


No. 170


 


SEQ ID
DTTMPAAMATK
177-187 for the protein of SEQ No. 137
TEM


No. 171


 


SEQ ID
DTTMPAAMATTLR
177-189 for the proteins of SEQ No. 1,
TEM


No. 172

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 27,




28, 29, 31, 32, 33, 34, 35, 36, 37, 38, 39,




40, 42, 43, 44, 45, 46, 47, 48, 49, 51, 52,




53, 54, 55, 56, 57, 58, 59, 61, 62, 63, 64,




65, 66, 68, 69, 70, 71, 72, 73, 74, 75, 76,




77, 78, 79, 80, 81, 84, 85, 90, 91, 92, 93,




94, 95, 96, 99, 100, 101, 102, 103, 105,




106, 108, 109, 110, 111, 112, 113, 115,




117, 118, 119, 120, 122, 123, 124, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 139, 140, 141, 142, 143, 144,




146, 148, 151, 152, 154, 155, 156, 157,




158, 159, 160, 161, 162, 163, 165, 1837,




1838, 1839, 1840, 1841, 1842, 1843,




1844


 


SEQ ID
DTTMPVAMATTLR
177-189 for the proteins of SEQ No.
TEM


No. 173

107, 145, 150


 


SEQ ID
DTTTPAAMATTLR
177-189 for the proteins of SEQ No. 19,
TEM


No. 174

30, 41, 50, 60, 67, 82, 83, 86, 87, 88, 89,




97, 98, 104, 114, 121, 125, 138, 147, 149,




153, 164


 


SEQ ID
ELTAFLHNIGDHVTR
145-159 for the protein of SEQ No. 144
TEM


No. 175


 


SEQ ID
ELTAFLHNMGDHVTR
145-159 for the proteins of SEQ No. 1,
TEM


No. 176

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 27,




28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,




39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49,




50, 51, 52, 53, 55, 56, 57, 58, 59, 60, 61,




62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,




73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83,




84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,




95, 96, 97, 98, 99, 100, 101, 102, 104,




105, 106, 107, 108, 109, 110, 111, 112,




113, 114, 115, 116, 119, 120, 121, 122,




123, 124, 125, 126, 127, 128, 129, 130,




131, 132, 133, 134, 135, 136, 137, 138,




139, 140, 141, 142, 143, 145, 146, 147,




148, 149, 150, 151, 152, 153, 154, 155,




156, 157, 158, 159, 160, 161, 162, 163,




164, 165, 1837, 1838, 1839, 1840, 1841,




1842, 1843, 1844


 


SEQ ID
ELTAFLHNMGDNVTR
145-159 for the protein of SEQ No. 117
2b


No. 177


 


SEQ ID
ELTAFLHNMGEHVTR
145-159 for the protein of SEQ No. 118
2b


No. 178


 


SEQ ID
ELTAFLR
145-151 for the proteins of SEQ No. 20,
2be


No. 179

54, 103


 


SEQ ID
EPELNEAIPNDER
164-176 for the proteins of SEQ No. 1,
TEM


No. 180

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 123, 124, 125, 126, 127,




129, 130, 131, 132, 133, 134, 135, 136,




137, 138, 139, 140, 141, 142, 143, 144,




145, 146, 147, 148, 149, 150, 151, 152,




153, 154, 155, 156, 157, 158, 159, 160,




161, 162, 163, 164, 1837, 1838, 1839,




1840, 1841, 1842, 1843, 1844


 


SEQ ID
ETTTPAAMATTLR
177-189 for the protein of SEQ No. 116
2be


No. 181


 


SEQ ID
FPMISTFK
64-71 for the proteins of SEQ No. 30,
2br


No. 182

35, 38, 147


 


SEQ ID
FPMLSTFK
64-71 for the proteins of SEQ No. 31,
TEM


No. 183

33, 37, 43, 48, 72, 76, 78, 100, 115, 142,




146, 157, 1838


 


SEQ ID
FPMMSTFK
64-71 for the proteins of SEQ No. 1, 2,
TEM


No. 184

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 39, 40, 41, 42, 44, 45, 46, 47,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 74, 79, 80, 81, 82, 83, 84, 85, 86, 87,




88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98,




99, 101, 102, 103, 104, 105, 106, 107,




108, 109, 110, 111, 112, 113, 114, 116,




117, 118, 119, 120, 121, 122, 123, 124,




125, 126, 127, 128, 129, 130, 131, 132,




133, 134, 135, 136, 137, 138, 139, 143,




144, 145, 149, 150, 151, 152, 153, 154,




155, 156, 158, 159, 160, 161, 162, 163,




164, 165, 1837, 1839, 1840, 1841, 1842,




1843, 1844


 


SEQ ID
FPMVSTFK
64-71 for the proteins of SEQ No. 32,
TEM


No. 185

34, 36, 73, 77, 140, 141, 148


 


SEQ ID
GEPELNEAIPNDER
163-176 for the protein of SEQ No. 157
2be


No. 186


 


SEQ ID
GIIAALGPDGKPSR
242-255 for the proteins of SEQ No. 1,
TEM


No. 187

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




143, 144, 145, 146, 147, 148, 149, 150,




151, 152, 153, 154, 155, 156, 157, 158,




159, 160, 161, 162, 163, 164, 1837, 1838,




1839, 1840, 1841, 1842, 1843, 1844;




241-254 for the protein of sequence




SEQ ID No. 165


 


SEQ ID
GSCGIIAALGPDGKPSR
239-255 for the proteins of SEQ No. 29,
2br


No. 188

61, 63, 68


 


SEQ ID
GSGGIIAALGPDGKPSR
239-255 for the protein of SEQ No. 74
2br


No. 189


 


SEQ ID
GSHGIIAALGPDGKPSR
239-255 for the proteins of SEQ No. 49,
2br


No. 190

134, 135


 


SEQ ID
GSLGIIAALGPDGKPSR
239-255 for the protein of SEQ No. 52
2br


No. 191


 


SEQ ID
GSSGIIAALGPDGKPSR
239-255 for the proteins of SEQ No. 28,
TEM


No. 192

42, 56, 69, 72, 111, 160, 161, 1844


 


SEQ ID
GSTGIIAALGPDGKPSR
239-255 for the protein of SEQ No. 39
TEM


No. 193


 


SEQ ID
HLPDGMTVR
110-118 for the protein of SEQ No. 135
TEM


No. 194


 


SEQ ID
HLTDGMTVR
110-118 for the proteins of SEQ No. 1,
TEM


No. 195

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 86, 87, 88, 89, 90, 91, 92, 93,




94, 95, 96, 97, 98, 99, 100, 101, 102, 103,




104, 105, 106, 107, 108, 109, 110, 111,




112, 113, 114, 115, 116, 117, 118, 119,




120, 121, 122, 123, 124, 125, 126, 127,




128, 129, 130, 131, 132, 133, 134, 136,




137, 138, 139, 140, 141, 142, 143, 144,




145, 146, 147, 148, 149, 150, 151, 152,




153, 155, 156, 157, 158, 159, 160, 161,




162, 163, 164, 165, 1837, 1838, 1839,




1840, 1841, 1842, 1843, 1844


 


SEQ ID
HLTGGMTVR
110-118 for the protein of SEQ No. 85
2b


No. 196


 


SEQ ID
IDAGQEQLGR
82-91 for the proteins of SEQ No. 107,
TEM


No. 197

145, 150, 159


 


SEQ ID
IHYSQNDLVEYSPVTEK
93-109 for the proteins of SEQ No. 1, 2,
TEM


No. 198

5, 7, 10, 11, 12, 13, 18, 19, 23, 25, 26, 27,




28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,




39, 40, 42, 43, 45, 46, 47, 49, 51, 52, 53,




55, 56, 57, 59, 61, 63, 64, 65, 66, 67, 68,




69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79,




80, 81, 85, 86, 88, 90, 91, 92, 93, 94, 95,




96, 99, 101, 103, 105, 106, 107, 108, 109,




110, 112, 115, 116, 117, 118, 122, 125,




126, 127, 130, 132, 133, 134, 135, 136,




137, 139, 140, 141, 142, 143, 144, 146,




147, 148, 151, 152, 153, 154, 156, 157,




158, 159, 160, 161, 162, 163, 165, 1837,




1838, 1839, 1840, 1841, 1842, 1843,




1844


 


SEQ ID
IHYSQNDLVK
93-102 for the proteins of SEQ No. 3, 4,
2be


No. 199

6, 8, 9, 14, 15, 16, 17, 20, 21, 22, 24, 41,




44, 48, 50, 54, 58, 60, 62, 82, 83, 84, 87,




89, 97, 98, 100, 102, 104, 111, 113, 114,




119, 120, 121, 123, 124, 128, 129, 131,




138, 149, 155, 164


 


SEQ ID
IHYSQSDLVEYSPVTEK
93-109 for the protein of SEQ No. 145
2be


No. 200


 


SEQ ID
IHYSQSDVVEYSPVTEK
93-109 for the protein of SEQ No. 150
TEM


No. 201


 


SEQ ID
ILESFRPEER
54-63 for the proteins of SEQ No. 1, 2,
TEM


No. 202

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




143, 144, 145, 146, 147, 148, 149, 151,




152, 153, 154, 155, 156, 157, 158, 159,




160, 161, 162, 163, 164, 165, 1837, 1838,




1839, 1840, 1841, 1842, 1843, 1844


 


SEQ ID
ILESFRPEK
54-62 for the protein of SEQ No. 150
TEM


No. 203


 


SEQ ID
IVIIYTTGSQATMDER
256-271 for the proteins of SEQ No. 56,
2br


No. 204

160


 


SEQ ID
IVVIYMTGGQATMDER
256-271 for the proteins of SEQ No. 47,
2be


No. 205

1842


 


SEQ ID
IVVIYMTGSQATMDELNR
256-273 for the protein of SEQ No. 64
2be


No. 206


 


SEQ ID
IVVIYMTGSQATMDER
256-271 for the proteins of SEQ No. 4,
TEM


No. 207

9, 13, 23, 25, 40, 45, 46, 68, 69, 70, 80,




81, 89, 93, 101, 102, 109, 131, 155, 156,




1840, 1841


 


SEQ ID
IVVIYTTGGQATMDER
256-271 for the protein of SEQ No. 126
2be


No. 208


 


SEQ ID
IVVIYTTGSQATMDELNR
256-273 for the proteins of SEQ No. 36,
2br


No. 209

94


 


SEQ ID
IVVIYTTGSQATMDEQNR
256-273 for the proteins of SEQ No. 43,
2br


No. 210

77, 78, 112, 151


 


SEQ ID
IVVIYTTGSQATMDER
256-271 for the proteins of SEQ No. 1,
TEM


No. 211

2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17,




18, 19, 20, 21, 22, 24, 26, 27, 28, 29, 30,




31, 32, 33, 34, 35, 37, 38, 39, 41, 42, 44,




48, 49, 50, 51, 52, 53, 54, 55, 57, 58, 59,




60, 61, 62, 63, 65, 66, 67, 71, 72, 73, 74,




75, 76, 79, 82, 83, 84, 85, 86, 87, 88, 90,




91, 92, 95, 96, 97, 98, 99, 100, 103, 104,




105, 106, 107, 108, 110, 111, 113, 114,




115, 116, 117, 118, 119, 120, 121, 122,




123, 124, 125, 127, 128, 129, 130, 132,




133, 134, 135, 136, 137, 138, 139, 140,




141, 142, 143, 144, 145, 146, 147, 148,




149, 150, 152, 153, 154, 157, 158, 159,




161, 162, 163, 164, 1837, 1838, 1839,




1843, 1844


 


SEQ ID
LDCWEPELNEAIPNDER
160-176 for the proteins of SEQ No. 86,
2be


No. 212

132, 133


 


SEQ ID
LDHWEPELNEAIPNDER
160-176 for the proteins of SEQ No. 6,
2be


No. 213

11, 15, 25, 26, 27, 41, 59, 70, 98, 100,




106, 109, 124, 136, 140, 141, 149, 1843


 


SEQ ID
LDHWEPELNEAVPNDER
160-176 for the protein of SEQ No. 122
2be


No. 214


 


SEQ ID
LDSWEPELNEAIPNDER
160-176 for the proteins of SEQ No. 5,
2be


No. 215

7, 8, 9, 10, 12, 22, 24, 44, 51, 58, 60, 80,




81, 93, 105, 111, 119, 120, 121, 123, 126,




127, 138, 142, 143, 146, 153, 164


 


SEQ ID
LHCWEPELNEAIPNDER
160-176 for the protein of SEQ No. 82
2be


No. 216


 


SEQ ID
LLTDELLTLASR
191-202 for the protein of SEQ No. 83
2be


No. 217


 


SEQ ID
LLTGELLTLASQQQLIDWMEADK
191-213 for the protein of SEQ No. 65
TEM


No. 218


 


SEQ ID
LLTGELLTLASR
191-202 for the proteins of SEQ No. 1,
TEM


No. 219

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 66, 67, 68, 69, 70, 71,




72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82,




84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,




95, 96, 97, 98, 100, 101, 102, 103, 104,




105, 106, 107, 108, 109, 110, 111, 112,




113, 114, 115, 116, 117, 118, 119, 120,




121, 122, 123, 124, 125, 126, 127, 128,




129, 130, 131, 132, 133, 134, 135, 136,




137, 138, 139, 140, 141, 142, 143, 144,




145, 146, 147, 148, 149, 150, 151, 152,




153, 154, 155, 156, 157, 158, 159, 160,




161, 162, 163, 164, 165, 1837, 1838,




1839, 1840, 1841, 1842, 1843, 1844


 


SEQ ID
LLTSELLTLASR
191-202 for the protein of SEQ No. 99
TEM


No. 220


 


SEQ ID
MSIQHFR
1-7 for the proteins of SEQ No. 1, 2, 3,
TEM


No. 221

4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,




17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27,




28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,




39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49,




50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60,




61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71,




72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 83,




84, 85, 86, 88, 89, 90, 91, 92, 93, 94, 95,




96, 97, 98, 99, 100, 101, 102, 103, 104,




105, 106, 107, 108, 109, 110, 111, 112,




115, 116, 117, 118, 119, 120, 121, 122,




123, 124, 125, 126, 127, 128, 129, 130,




131, 132, 133, 134, 135, 136, 137, 138,




139, 140, 141, 142, 143, 144, 145, 146,




147, 148, 150, 151, 152, 153, 154, 155,




156, 157, 158, 159, 160, 161, 162, 163,




165, 1837, 1838, 1839, 1840, 1841, 1842,




1843, 1844


 


SEQ ID
NMGDHVTR
152-159 for the proteins of SEQ No. 1,
2be


No. 222

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 119, 120,




121, 122, 123, 124, 125, 126, 127, 128,




129, 130, 131, 132, 133, 134, 135, 136,




137, 138, 139, 140, 141, 142, 143, 145,




146, 147, 148, 149, 150, 151, 152, 153,




154, 155, 156, 157, 158, 159, 160, 161,




162, 163, 164, 165, 1837, 1838, 1839,




1840, 1841, 1842, 1843, 1844


 


SEQ ID
QIAEICASLIK
274-284 for the protein of SEQ No. 158
TEM


No. 223


 


SEQ ID
QIAEIGASLIK
274-284 for the proteins of SEQ No. 1,
TEM


No. 224

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 93,




94, 96, 97, 98, 99, 100, 101, 102, 103,




104, 105, 106, 107, 108, 109, 110, 111,




112, 113, 114, 115, 116, 117, 118, 119,




120, 121, 122, 123, 124, 125, 126, 127,




128, 129, 130, 131, 132, 133, 134, 135,




136, 137, 138, 139, 141, 142, 143, 144,




145, 146, 147, 148, 149, 150, 151, 153,




154, 155, 156, 157, 159, 160, 161, 162,




163, 164, 1837, 1838, 1839, 1840, 1841,




1842, 1843, 1844; 273-283 for the




protein of sequence SEQ ID No. 165


 


SEQ ID
QIAEIGGSLIK
274-284 for the protein of SEQ No. 140
2be


No. 225


 


SEQ ID
QIVEIGASLIK
274-284 for the proteins of SEQ No. 92,
2be


No. 226

95


 


SEQ ID
QQLIDWMADK
203-212 for the protein of SEQ No. 165
2be


No. 227


 


SEQ ID
QQLIDWMEADK
203-213 for the proteins of SEQ No. 1,
TEM


No. 228

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




143, 144, 145, 146, 147, 148, 149, 150,




151, 152, 153, 154, 155, 156, 157, 158,




159, 163, 164, 1837, 1838, 1839, 1840,




1841, 1842, 1843, 1844


 


SEQ ID
QQLIDWMEVDK
203-213 for the proteins of SEQ No.
TEM


No. 229

160, 161, 162


 


SEQ ID
QTAEIGASLIK
274-284 for the protein of SEQ No. 152
2be


No. 230


 


SEQ ID
SALPAGWFIADK
221-232 for the proteins of SEQ No. 1,
TEM


No. 231

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 137, 138, 139, 140, 141, 142, 143,




144, 145, 146, 147, 148, 149, 150, 151,




152, 153, 154, 156, 157, 158, 159, 160,




161, 162, 164, 1837, 1838, 1839, 1840,




1841, 1842, 1843, 1844; 220-231 for the




protein of sequence SEQ ID No. 165


 


SEQ ID
SGADER
233-238 for the protein of SEQ No. 102
TEM


No. 232


 


SEQ ID
SGAGER
233-238 for the proteins of SEQ No. 1,
TEM


No. 233

2, 6, 7, 9, 11, 12, 13, 15, 16, 17, 24, 27,




28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,




39, 41, 42, 43, 49, 51, 52, 53, 54, 55, 56,




57, 58, 60, 61, 63, 65, 68, 69, 70, 71, 72,




73, 74, 75, 76, 77, 78, 79, 82, 85, 90, 91,




93, 94, 95, 96, 97, 99, 100, 101, 106, 107,




108, 109, 112, 114, 115, 116, 117, 118,




119, 123, 125, 130, 132, 134, 135, 136,




137, 139, 140, 142, 144, 145, 146, 147,




148, 149, 150, 151, 152, 153, 154, 156,




157, 158, 159, 160, 161, 162, 163, 1837,




1838, 1839, 1843, 1844


 


SEQ ID
SGAGVR
233-238 for the protein of SEQ No. 138
2be


No. 234


 


SEQ ID
SGANER
233-238 for the protein of SEQ No. 131
TEM


No. 235


 


SEQ ID
SGASER
233-238 for the proteins of SEQ No. 3,
2be


No. 236

4, 8, 14, 18, 19, 20, 23, 48, 50, 62, 83, 84,




87, 89, 98, 103, 104, 110, 113, 124, 128,




129, 155


 


SEQ ID
SGASK
233-237 for the proteins of SEQ No. 40,
2be


No. 237

45, 46, 47, 64, 66, 67, 88, 92, 1840, 1841,




1842


 


SEQ ID
SGGSER
233-238 for the protein of SEQ No. 21
2be


No. 238


 


SEQ ID
SGTGER
233-238 for the proteins of SEQ No.
2be


No. 239

120, 121


 


SEQ ID
SVLPAGWFIADK
221-232 for the proteins of SEQ No.
2be


No. 240

136, 155, 163


 


SEQ ID
VAEPLLR
214-220 for the protein of SEQ No. 53
2b


No. 241


 


SEQ ID
VAGPLLR
214-220 for the proteins of SEQ No. 1,
TEM


No. 242

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 54, 55, 56, 57, 58, 59, 60,




61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71,




72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82,




83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93,




94, 95, 96, 97, 98, 99, 100, 101, 102, 103,




104, 105, 106, 107, 108, 109, 110, 111,




112, 113, 114, 115, 116, 117, 118, 119,




120, 121, 122, 123, 124, 125, 126, 127,




128, 129, 130, 131, 132, 133, 135, 136,




137, 138, 139, 140, 141, 142, 143, 144,




145, 146, 147, 148, 149, 150, 151, 152,




153, 154, 155, 156, 157, 158, 159, 160,




161, 162, 163, 164, 1837, 1838, 1839,




1840, 1841, 1842, 1843, 1844; 213-219




for the protein of sequence SEQ ID No.




165


 


SEQ ID
VAGPLMR
214-220 for the protein of SEQ No. 134
2br


No. 243


 


SEQ ID
VALIPFFAAFCFPVFAHPETLVK
8-30 for the proteins of SEQ No. 4, 9,
TEM


No. 244

23, 46, 47, 51, 60, 68, 69, 70, 80, 81, 89,




93, 101, 106, 108, 110, 121, 123, 147,




155, 1841, 1842


 


SEQ ID
VALIPFFAAFCIPVFAHPETLVK
8-30 for the protein of SEQ No. 63
2br


No. 245


 


SEQ ID
VALIPFFAAFCLPVFAHPDTLVK
8-30 for the protein of SEQ No. 139
TEM


No. 246


 


SEQ ID
VALIPFFAAFCLPVFAHPETLVK
8-30 for the proteins of SEQ No. 1, 2, 3,
TEM


No. 247

5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17,




18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29,




30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40,




41, 42, 43, 44, 45, 48, 49, 50, 52, 53, 54,




55, 56, 57, 58, 59, 61, 62, 64, 65, 66, 67,




71, 72, 73, 74, 75, 76, 77, 78, 79, 82, 83,




84, 85, 86, 87, 88, 90, 91, 92, 94, 95, 96,




97, 98, 99, 100, 102, 103, 104, 105, 107,




109, 111, 112, 113, 114, 116, 117, 118,




119, 120, 122, 124, 125, 126, 127, 128,




129, 130, 131, 132, 133, 134, 135, 136,




137, 138, 140, 141, 142, 143, 144, 145,




146, 148, 149, 151, 152, 153, 154, 156,




157, 158, 159, 160, 161, 162, 163, 164,




165, 1837, 1838, 1839, 1840, 1843, 1844


 


SEQ ID
VALIPFFAAFCLPVFAHPK
8-26 for the protein of SEQ No. 150
TEM


No. 248


 


SEQ ID
VALIPFLAAFCLPVFAHPETLVK
8-30 for the protein of SEQ No. 115
2be


No. 249


 


SEQ ID
VDAGQEQLDR
82-91 for the proteins of SEQ No. 55,
TEM


No. 250

62


 


SEQ ID
VDAGQEQLGR
82-91 for the proteins of SEQ No. 1, 2,
TEM


No. 251

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 56, 57, 58, 59, 60,




61, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,




73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83,




84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,




95, 96, 97, 98, 99, 100, 101, 102, 103,




104, 105, 106, 108, 109, 110, 111, 112,




113, 114, 115, 116, 117, 118, 119, 120,




121, 122, 123, 124, 125, 126, 127, 128,




129, 130, 131, 132, 133, 134, 135, 136,




137, 138, 139, 140, 141, 142, 143, 144,




146, 147, 148, 149, 151, 152, 153, 154,




155, 156, 157, 158, 160, 161, 162, 163,




164, 165, 1837, 1838, 1839, 1840, 1841,




1842, 1843, 1844


 


SEQ ID
VEDAEDQLGAR
31-41 for the protein of SEQ No. 130
2b


No. 252


 


SEQ ID
VGYIELDLNSGK
42-53 for the proteins of SEQ No. 1, 2,
TEM


No. 253

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 59, 60,




61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71,




72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82,




83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93,




94, 95, 96, 97, 98, 99, 100, 101, 102, 103,




104, 105, 106, 107, 108, 109, 110, 111,




112, 113, 114, 115, 116, 117, 118, 119,




120, 121, 122, 123, 124, 125, 126, 127,




128, 130, 131, 132, 133, 134, 135, 136,




137, 138, 139, 140, 141, 142, 143, 144,




145, 146, 147, 148, 149, 150, 151, 152,




153, 154, 155, 156, 157, 158, 159, 160,




161, 162, 163, 164, 1837, 1838, 1839,




1840, 1841, 1842, 1843, 1844


 


SEQ ID
VGYIELDPNSGK
42-53 for the protein of SEQ No. 58
2be


No. 254


 


SEQ ID
VGYIEMDLNSGK
42-53 for the protein of SEQ No. 129
2be


No. 255


 


SEQ ID
VKPAEDK
31-37 for the protein of SEQ No. 120
2be


No. 256


 


SEQ ID
VLLCGAELSR
72-81 for the protein of SEQ No. 99
TEM


No. 257


 


SEQ ID
VLLCGAVLSR
72-81 for the proteins of SEQ No. 1, 2,
TEM


No. 258

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 100, 101, 102, 103,




104, 105, 106, 107, 108, 109, 110, 111,




112, 113, 114, 115, 116, 117, 118, 119,




120, 121, 122, 123, 124, 125, 126, 127,




128, 129, 130, 131, 132, 133, 134, 135,




136, 137, 138, 139, 140, 141, 142, 143,




144, 145, 146, 147, 148, 149, 150, 151,




152, 153, 154, 155, 156, 157, 158, 159,




160, 161, 162, 163, 164, 165, 1837, 1838,




1839, 1840, 1841, 1842, 1843, 1844


 


SEQ ID
WEPELNEAIPIDER
163-176 for the protein of SEQ No. 128
2be


No. 259


 


SEQ ID
WEPELNEAIPNDER
163-176 for the proteins of SEQ No. 1,
TEM


No. 260

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 38,




39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49,




50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60,




61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71,




72, 74, 75, 76, 77, 79, 80, 81, 82, 83, 84,




85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95,




96, 97, 98, 99, 100, 101, 102, 103, 104,




105, 106, 107, 108, 109, 110, 111, 112,




113, 114, 116, 117, 118, 119, 120, 121,




123, 124, 125, 126, 127, 129, 130, 131,




132, 133, 134, 135, 136, 137, 138, 139,




140, 141, 142, 143, 144, 145, 146, 147,




148, 149, 150, 151, 152, 153, 154, 155,




156, 158, 159, 160, 161, 162, 163, 164,




1837, 1838, 1839, 1840, 1841, 1842,




1843, 1844


 


SEQ ID
YSPVTEK
103-109 for the proteins of SEQ No. 1,
2be


No. 261

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,




16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




143, 144, 145, 146, 147, 148, 149, 150,




151, 152, 153, 154, 155, 156, 157, 158,




159, 160, 161, 162, 163, 164, 165, 1837,




1838, 1839, 1840, 1841, 1842, 1843,




1844


 


SEQ ID
DAEDK
33-37 for the proteins of SEQ No. 2, 3,
TEM


No.

7, 8, 11, 13, 15, 17, 20, 21, 22, 40, 42, 44,


1923

54, 57, 58, 59, 61, 62, 63, 67, 84, 92, 104,




105, 111, 119, 124, 129, 143, 148, 164,




1839


 


SEQ ID
GIIAALGPDGK
242-252 for the proteins of SEQ No. 1,
TEM


No.

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,


1924

16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




143, 144, 145, 146, 147, 148, 149, 150,




151, 152, 153, 154, 155, 156, 157, 158,




159, 160, 161, 162, 163, 164, 1837, 1838,




1839, 1840, 1841, 1842, 1843, 1844;




241-251 for the protein of sequence




SEQ ID No. 165


 


SEQ ID
GSSGIIAALGPDGK
239-252 for the proteins of SEQ No. 28,
TEM


No.

42, 56, 69, 72, 111, 160, 161, 1844


1925


 


SEQ ID
ILESFR
54-59 for the proteins of SEQ No. 1, 2,
TEM


No.

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,


1926

16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,




27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,




38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,




49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,




60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70,




71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,




82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92,




93, 94, 95, 96, 97, 98, 99, 100, 101, 102,




103, 104, 105, 106, 107, 108, 109, 110,




111, 112, 113, 114, 115, 116, 117, 118,




119, 120, 121, 122, 123, 124, 125, 126,




127, 128, 129, 130, 131, 132, 133, 134,




135, 136, 137, 138, 139, 140, 141, 142,




143, 144, 145, 146, 147, 148, 149, 150,




151, 152, 153, 154, 155, 156, 157, 158,




159, 160, 161, 162, 163, 164, 165, 1837,




1838, 1839, 1840, 1841, 1842, 1843,




1844


 


SEQ ID
SGAGK
233-237 for the proteins of SEQ No. 10,
2be


No.

25, 26, 44, 59, 80, 86, 122, 133, 141, 143


1927


 


SEQ ID
SGTGK
233-237 for the proteins of SEQ No. 5,
2be


No.

22, 81, 105, 111, 126, 164


1928









In the clinical interest column, the entries 2b, 2br, 2be and 2ber correspond to the functional subgroups of TEM beta-lactamases which the corresponding peptide makes it possible to detect. Thus, the detection of a 2be peptide indicates the presence of a beta-lactamase with an extended spectrum (ESBL) capable of hydrolysing penicillins, first-generation cephalosporins such as cephaloridine and cefalotin, and at least one antibiotic from the oxyimino-beta-lactam class such as cefotaxime, ceftazidime or monobactams such as aztreonam.
The entry TEM indicates a common peptide between at least two of the subgroups 2b, 2br and 2be or 2ber. The corresponding peptide indicates the presence of a TEM beta-lactamase and the presence of a mechanism of resistance to at least penicillins and first-generation cephalosporins.
The detection of a mechanism of resistance to ESBL (extended-spectrum beta-lactamase) cephalosporins, induced by the TEM protein, is characterised by the detection of at least one resistance-marking 2be peptide, chosen from the sequences SEQ ID No. 168, SEQ ID No. 169, SEQ ID No. 179, SEQ ID No. 181, SEQ ID No. 186, SEQ ID No. 199, SEQ ID No. 200, SEQ ID No. 205, SEQ ID No. 206, SEQ ID No. 208, SEQ ID No. 212, SEQ ID No. 213, SEQ ID No. 214, SEQ ID No. 215, SEQ ID No. 216, SEQ ID No. 217, SEQ ID No. 222, SEQ ID No. 225, SEQ ID No. 226, SEQ ID No. 227, SEQ ID No. 230, SEQ ID No. 234, SEQ ID No. 236, SEQ ID No. 237, SEQ ID No. 238, SEQ ID No. 239, SEQ ID No. 240, SEQ ID No. 249, SEQ ID No. 254, SEQ ID No. 255, SEQ ID No. 256, SEQ ID No. 259, SEQ ID No. 261, SEQ ID No. 1927, SEQ ID No. 1928.
The detection of a mechanism of resistance to cephalosporins induced by the expression of the CMY protein is characterised by the detection of at least one peptide belonging to the CMY protein and to its different sequence variants SEQ ID No. 262 to SEQ ID No. 311 and SEQ ID No. 1844 to SEQ ID No. 1870.








SEQ ID No. 262:



MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTH


 


KGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG


 


SEQ ID No. 263:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTH


 


QGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG


 


SEQ ID No. 264:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTH


 


QGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG


 


SEQ ID No. 265:


MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREG


 


KPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 266:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAFAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 267:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGNGSDSKVALAALPAVEVNPPAPAVKASW


 


VHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 268:


MKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREG


 


KPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 269:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGKLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 270:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAYWRILEKLQ


 


SEQ ID No. 271:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAGAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 272:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLY


 


ANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 273:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 274:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVYVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 275:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 276:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 277:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 278:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 279:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 280:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLY


 


ANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 281:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYACGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 282:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLY


 


ANSSIGLFGTLAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASHVQEKTLQQGIELAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGYTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 283:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPEQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 284:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 285:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFAALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 286:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAPAVEVNPPAPAVKASWVHKTGS


 


TGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 287:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREG


 


KPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALHTVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFIPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 288:


MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYAN


 


SSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGK


 


PVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRI


 


GDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTG


 


STGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ


 


SEQ ID No. 289:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLELDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQS


 


RYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASW


 


VHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 290:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGEAIARGEIKLSDPVTKYWPE


 


LTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLY


 


ANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 291:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQFDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 292:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKTDSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 293:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTH


 


KGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG


 


SEQ ID No. 294:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTH


 


KGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG


 


SEQ ID No. 295:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWS


 


ELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLY


 


ANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASRVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAAIPAVEVNPPAPAVKASWVHK


 


TGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPIRVEAAWRILEKLQ


 


SEQ ID No. 296:


MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKT


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQDISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLY


 


ANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 297:


MMKKSLCCALLLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPE


 


LTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREG


 


KAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 298:


MMKKSICCALLLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYAN


 


SSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGK


 


PVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRI


 


GDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTG


 


STGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ


 


SEQ ID No. 299:


GPGHLFAFNYGTDFMMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQ


 


AIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIAR


 


GEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQN


 


WQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVP


 


QNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASHVQE


 


KTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEV


 


NPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRIL


 


EKLQ


 


SEQ ID No. 300:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 301:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTH


 


QGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG


 


SEQ ID No. 302:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 303:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 304:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 305:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 306:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYALGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 307:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 308:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 309:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHK


 


TGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 310:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 311:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLNAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1844:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTH


 


QGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG


 


SEQ ID No. 1845:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTH


 


QGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG


 


SEQ ID No. 1846:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAFAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1847:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGNGSDSKVALAALPAVEVNPPAPAVKASW


 


VHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1848:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAYWRILEKLQ


 


SEQ ID No. 1849:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1850:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1851:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAPAVEVNPPAPAVKASWVHKTGS


 


TGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1852:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVLYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYLPE


 


LTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREG


 


KPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPTVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1853:


MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYAN


 


SSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGK


 


PVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRI


 


GDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTG


 


STGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ


 


SEQ ID No. 1854:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKTDSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1855:


MMKKSLCCALLLTASLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAIAVIYQGKPY


 


YFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREG


 


KAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1856:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYCVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1857:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPVTKYWPE


 


LTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLY


 


ANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1858:


MMNRYAAALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPY


 


YFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPEL


 


TGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYA


 


NSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREG


 


KPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKT


 


GSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1859:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFSALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1860:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTH


 


KGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG


 


SEQ ID No. 1861:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTH


 


KGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG


 


SEQ ID No. 1862:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1863:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAV


 


LKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDK


 


ASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYS


 


PGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMAS


 


YAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTH


 


QGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFN


 


KTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG


 


SEQ ID No. 1864:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1865:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1866:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYR


 


EGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1867:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1868:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHK


 


TGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1869:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLQIIDDDVRDKAALLHFYQNWQPQWTPGAKRL


 


YSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYRE


 


GKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRY


 


WRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH


 


KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ


 


SEQ ID No. 1870:


MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKP


 


YYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWP


 


ELTGKQWQGIRLLHLATYTAGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLY


 


SNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREG


 


KPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYW


 


RIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKT


 


GSTVGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 312 to SEQ ID No. 350, SEQ ID No. 734, SEQ ID No. 735 and SEQ ID No. 1929 to SEQ ID No. 2007, as defined hereafter:












Peptide




SEQ ID


No.
Amino acid sequence
Position of the peptide in the CMY protein







SEQ ID
AALLHFYQNWQPQWTPGAK
149-167 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No. 312

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 283, 284, 285,




286, 289, 290, 291, 292, 300, 302, 303, 304, 305, 306, 307, 308,




309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1854, 1856,




1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;




148-166 for the protein of sequence SEQ ID No. 268; 163-181




for the protein of sequence SEQ ID No. 299; 148-166 for the




protein of sequence SEQ ID No. 1858


 


SEQ ID
ADIANNHPVTQQTLFELGSV
66-87 for the proteins of SEQ No. 265, 266, 267, 269, 270, 271,


No. 313
SK
272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,




285, 286, 287, 288, 289, 290, 291, 292, 295, 296, 298, 300, 302,




303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848,




1849, 1850, 1851, 1852, 1853, 1854, 1856, 1857, 1859, 1862,




1864, 1865, 1866, 1867, 1868, 1869, 1870; 65-86 for the protein




of sequence SEQ ID No. 268; 80-101 for the protein of




sequence SEQ ID No. 299; 65-86 for the protein of sequence




SEQ ID No. 1858


 


SEQ ID
ADSIINGSDSK
300-310 for the proteins of SEQ No. 265, 266, 269, 270, 271,


No. 314

272, 273, 274, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285,




286, 287, 288, 290, 291, 295, 296, 297, 298, 300, 302, 303, 304,




305, 306, 307, 308, 309, 310, 311, 1846, 1848, 1850, 1851,




1852, 1853, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866,




1867, 1868, 1869, 1870; 302-312 for the protein of sequence




SEQ ID No. 289; 314-324 for the protein of sequence SEQ ID




No. 299; 299-309 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
ASWVHK
330-335 for the proteins of SEQ No. 265, 266, 269, 270, 271,


No. 315

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285,




287, 288, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304,




305, 306, 307, 308, 309, 310, 311, 1846, 1848, 1849, 1852,




1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866,




1867, 1868, 1869, 1870; 332-337 for the protein of sequence




SEQ ID No. 267; 329-334 for the protein of sequence SEQ ID




No. 268; 328-333 for the protein of sequence SEQ ID No. 284;




326-331 for the protein of sequence SEQ ID No. 286; 332-337




for the protein of sequence SEQ ID No. 289; 344-349 for the




protein of sequence SEQ ID No. 299; 332-337 for the protein of




sequence SEQ ID No. 1847; 328-333 for the protein of




sequence SEQ ID No. 1850; 326-331 for the protein of




sequence SEQ ID No. 1851; 329-334 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
DYAWGYR
218-224 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 316

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 282, 283, 284,




285, 286, 287, 289, 290, 291, 292, 295, 296, 297, 300, 305, 307,




1846, 1847, 1848, 1849, 1850, 1851, 1852, 1854, 1855, 1856,




1857, 1859, 1862, 1866; 217-223 for the protein of sequence




SEQ ID No. 268; 232-238 for the protein of sequence SEQ ID




No. 299; 217-223 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
IGDMYQGLGWEMLNWPLK
282-299 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 317

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,




284, 285, 286, 287, 288, 290, 291, 292, 295, 296, 297, 298, 300,




302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847,




1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1857,




1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 281-298




for the protein of sequence SEQ ID No. 268; 284-301 for




the protein of sequence SEQ ID No. 289; 296-313 for the




protein of sequence SEQ ID No. 299; 281-298 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
LAHTWITVPQNEQK
204-217 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 318

271, 272, 273, 274, 275, 276, 277, 278, 280, 281, 283, 284, 285,




286, 287, 289, 290, 291, 292, 300, 302, 303, 304, 305, 306, 307,




308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852,




1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867,




1868, 1869, 1870; 203-216 for the protein of sequence SEQ ID




No. 268; 218-231 for the protein of sequence SEQ ID No. 299;




203-216 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
LLHLATYTAGGLPLQIPDDVR
126-146 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No. 319

273, 274, 275, 276, 278, 279, 281, 283, 284, 285, 286, 289, 290,




291, 292, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311,




1846, 1847, 1848, 1849, 1850, 1851, 1854, 1856, 1857, 1859,




1862, 1864, 1865, 1866, 1867, 1868, 1869; 140-160 for the




protein of sequence SEQ ID No. 299; 125-145 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
LSDPVTK
105-111 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 320

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,




284, 285, 286, 287, 288, 289, 290, 291, 292, 295, 296, 297, 298,




300, 302, 303, 304, 305, 306, 308, 309, 310, 311, 1846, 1847,




1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1857,




1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 104-110




for the protein of sequence SEQ ID No. 268; 119-125 for




the protein of sequence SEQ ID No. 299; 104-110 for the




protein of sequence SEQ ID No. 1858


 


SEQ ID
LYANSSIGLFGALAVK
169-184 for the proteins of SEQ No. 265, 266, 267, 270, 271,


No. 321

272, 273, 274, 276, 278, 279, 280, 281, 283, 284, 286, 287, 289,




290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 306, 307, 308,




309, 311, 1846, 1847, 1848, 1850, 1851, 1852, 1853, 1854,




1855, 1856, 1857, 1862, 1864, 1867, 1868; 168-183 for the




protein of sequence SEQ ID No. 268; 183-198 for the protein of




sequence SEQ ID No. 299; 168-183 for the protein of sequence




SEQ ID No. 1858


 


SEQ ID
NLGIVMLANK
353-362 for the proteins of SEQ No. 265, 266, 269, 270, 271,


No. 322

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285,




287, 288, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304,




305, 306, 307, 308, 309, 310, 311, 1846, 1848, 1849, 1852,




1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866,




1867, 1868, 1869, 1870; 355-364 for the protein of sequence




SEQ ID No. 267; 352-361 for the protein of sequence SEQ ID




No. 268; 351-360 for the protein of sequence SEQ ID No. 284;




349-358 for the protein of sequence SEQ ID No. 286; 355-364




for the protein of sequence SEQ ID No. 289; 367-376 for the




protein of sequence SEQ ID No. 299; 355-364 for the protein of




sequence SEQ ID No. 1847; 351-360 for the protein of




sequence SEQ ID No. 1850; 349-358 for the protein of




sequence SEQ ID No. 1851; 352-361 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
QWQGIR
120-125 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No. 323

273, 274, 275, 276, 277, 278, 279, 280, 281, 283, 284, 285, 286,




289, 290, 291, 292, 300, 302, 303, 304, 305, 306, 307, 308, 309,




310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1854, 1856,




1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;




134-139 for the protein of sequence SEQ ID No. 299; 119-124




for the protein of sequence SEQ ID No. 1858


 


SEQ ID
SLCCALLLTASFSTFAAAK
5-23 for the proteins of SEQ No. 266, 267, 269, 270, 271, 272,


No. 324

273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285,




286, 287, 289, 290, 291, 292, 295, 300, 302, 303, 304, 305, 306,




307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851,




1852, 1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867,




1868, 1869, 1870; 4-22 for the protein of sequence SEQ ID No.




268; 19-37 for the protein of sequence SEQ ID No. 299


 


SEQ ID
SSVIDMAR
245-252 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No. 325

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 283, 284, 285,




286, 288, 290, 291, 292, 295, 297, 298, 300, 302, 303, 304, 305,




306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850,




1851, 1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865,




1866, 1867, 1868, 1869, 1870; 244-251 for the protein of




sequence SEQ ID No. 268; 247-254 for the protein of sequence




SEQ ID No. 289; 259-266 for the protein of sequence SEQ ID




No. 299; 244-251 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
SYPNPVR
363-369 for the proteins of SEQ No. 265, 266, 269, 270, 271,


No. 326

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285,




287, 290, 291, 292, 296, 297, 300, 302, 303, 305, 306, 307, 309,




310, 1846, 1848, 1849, 1852, 1854, 1855, 1856, 1857, 1859,




1862, 1864, 1866, 1868, 1869, 1870; 365-371 for the protein of




sequence SEQ ID No. 267; 362-368 for the protein of sequence




SEQ ID No. 268; 361-367 for the protein of sequence SEQ ID




No. 284; 359-365 for the protein of sequence SEQ ID No. 286;




365-371 for the protein of sequence SEQ ID No. 289; 377-383




for the protein of sequence SEQ ID No. 299; 365-371 for the




protein of sequence SEQ ID No. 1847; 361-367 for the protein




of sequence SEQ ID No. 1850; 359-365 for the protein of




sequence SEQ ID No. 1851; 362-368 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
TEQQIADIVNR
24-34 for the proteins of SEQ No. 265, 266, 267, 269, 270, 271,


No. 327

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,




285, 286, 287, 288, 289, 290, 291, 292, 295, 296, 297, 298, 300,




302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847,




1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1857,




1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 23-33




for the protein of sequence SEQ ID No. 268; 38-48 for the




protein of sequence SEQ ID No. 299; 23-33 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
TFNGVLGGDAIAR
88-100 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 328

271, 272, 273, 274, 275, 276, 277, 278, 280, 281, 282, 283, 284,




285, 286, 287, 288, 289, 291, 292, 295, 296, 297, 298, 300, 302,




303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848,




1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1859, 1862,




1864, 1865, 1866, 1867, 1868, 1869, 1870; 87-99 for the protein




of sequence SEQ ID No. 268; 102-114 for the protein of




sequence SEQ ID No. 299; 87-99 for the protein of sequence




SEQ ID No. 1858


 


SEQ ID
TGSTGGFGSYVAFVPEK
336-352 for the proteins of SEQ No. 265, 266, 269, 270, 271,


No. 329

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 283, 285, 288,




290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304, 305, 306,




307, 308, 309, 310, 311, 1846, 1848, 1849, 1852, 1853, 1854,




1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868,




1869; 338-354 for the protein of sequence SEQ ID No. 267;




335-351 for the protein of sequence SEQ ID No. 268; 334-350




for the protein of sequence SEQ ID No. 284; 332-348 for the




protein of sequence SEQ ID No. 286; 338-354 for the protein of




sequence SEQ ID No. 289; 350-366 for the protein of sequence




SEQ ID No. 299; 338-354 for the protein of sequence SEQ ID




No. 1847; 334-350 for the protein of sequence SEQ ID No.




1850; 332-348 for the protein of sequence SEQ ID No. 1851;




335-351 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
TITPLMQEQAIPGMAVAVIYQ
35-57 for the proteins of SEQ No. 266, 267, 269, 270, 271, 272,


No. 330
GK
273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285,




286, 289, 290, 291, 292, 295, 296, 297, 300, 302, 303, 304, 305,




306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850,




1851, 1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867,




1868, 1869, 1870; 34-56 for the protein of sequence SEQ ID




No. 268; 49-71 for the protein of sequence SEQ ID No. 299; 34-56




for the protein of sequence SEQ ID No. 1858


 


SEQ ID
TLQQGIALAQSR
267-278 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 331

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 283, 284,




285, 286, 287, 290, 291, 292, 295, 296, 297, 300, 302, 303, 304,




305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849,




1850, 1851, 1852, 1854, 1855, 1856, 1857, 1859, 1862, 1864,




1865, 1866, 1867, 1868, 1869, 1870; 266-277 for the protein of




sequence SEQ ID No. 268; 269-280 for the protein of sequence




SEQ ID No. 289; 281-292 for the protein of sequence SEQ ID




No. 299; 266-277 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
VALAALPAVEVNPPAPAVK
311-329 for the proteins of SEQ No. 265, 269, 270, 271, 272,


No. 332

273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285, 288,




290, 291, 292, 296, 297, 298, 300, 302, 303, 304, 305, 306, 307,




308, 310, 311, 1848, 1849, 1853, 1854, 1855, 1856, 1857, 1859,




1862, 1864, 1865, 1866, 1867, 1869, 1870; 313-331 for the




protein of sequence SEQ ID No. 267; 310-328 for the protein of




sequence SEQ ID No. 268; 313-331 for the protein of sequence




SEQ ID No. 289; 325-343 for the protein of sequence SEQ ID




No. 299; 313-331 for the protein of sequence SEQ ID No. 1847;




310-328 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
VEAAWR
370-375 for the proteins of SEQ No. 265, 266, 269, 271, 272,


No. 333

273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285, 287,




288, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304, 305,




306, 307, 308, 309, 310, 311, 1846, 1849, 1852, 1853, 1854,




1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868,




1869, 1870; 372-377 for the protein of sequence SEQ ID No.




267; 369-374 for the protein of sequence SEQ ID No. 268; 368-373




for the protein of sequence SEQ ID No. 284; 366-371 for




the protein of sequence SEQ ID No. 286; 372-377 for the




protein of sequence SEQ ID No. 289; 384-389 for the protein of




sequence SEQ ID No. 299; 372-377 for the protein of sequence




SEQ ID No. 1847; 368-373 for the protein of sequence SEQ ID




No. 1850; 366-371 for the protein of sequence SEQ ID No.




1851; 369-374 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
VLQPLK
198-203 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 334

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,




284, 285, 286, 287, 288, 289, 290, 291, 292, 295, 296, 297, 298,




300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846,




1847, 1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856,




1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;




197-202 for the protein of sequence SEQ ID No. 268; 212-217




for the protein of sequence SEQ ID No. 299; 197-202 for the




protein of sequence SEQ ID No. 1858


 


SEQ ID
WVQANMDASHVQEK
253-266 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No. 335

272, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285,




286, 288, 290, 291, 292, 298, 300, 302, 303, 304, 305, 306, 307,




308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1853,




1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868,




1869, 1870; 252-265 for the protein of sequence SEQ ID No.




268; 255-268 for the protein of sequence SEQ ID No. 289; 267-280




for the protein of sequence SEQ ID No. 299; 252-265 for




the protein of sequence SEQ ID No. 1858


 


SEQ ID
YWPELTGK
112-119 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 336

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,




284, 285, 286, 287, 288, 289, 290, 291, 292, 296, 297, 298, 300,




302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847,




1848, 1849, 1850, 1851, 1853, 1854, 1855, 1856, 1857, 1859,




1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 111-118 for




the protein of sequence SEQ ID No. 268; 126-133 for the




protein of sequence SEQ ID No. 299; 111-118 for the protein of




sequence SEQ ID No. 1858


 


SEQ ID
AHYFNYGVANR
62-72 for the proteins of SEQ No. 262, 263, 264, 293, 294, 301,


No. 337

1844, 1845, 1860, 1861, 1863


 


SEQ ID
ANIGGVDDK
261-269 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 338

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
ESGSQVLFNK
326-335 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 339

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
GAMQLDDK
105-112 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 340

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
GIGIVMLANR
353-362 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 341

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
HAPWLK
116-121 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 342

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
IPGMAVAVLK
49-58 for the proteins of SEQ No. 262, 263, 264, 293, 294, 301,


No. 343

1844, 1845, 1860, 1861, 1863


 


SEQ ID
PVVDASIQPLLK
34-45 for the proteins of SEQ No. 262, 263, 264, 293, 294, 301,


No. 344

1844, 1845, 1860, 1861, 1863


 


SEQ ID
QAMASYAYGYSK
218-229 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 345

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
QWAPVYSPGSHR
161-172 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 346

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
QYSNPSIGLFGHLAASSLK
173-191 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 347

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
TGSTNGFGAYVAFVPAR
336-352 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 348

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
TLTATLGAYAVVK
92-104 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 349

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
VNPGMLADEAYGIK
236-249 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No. 350

301, 1844, 1845, 1860, 1861, 1863


 


SEQ ID
PSGMSYEEAMTR
185-196 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No. 734

271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,




284, 285, 286, 287, 288, 289, 290, 291, 292, 295, 296, 297, 298,




300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846,




1847, 1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856,




1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;




184-195 for the protein of sequence SEQ ID No. 268; 199-210




for the protein of sequence SEQ ID No. 299; 184-195 for the




protein of sequence SEQ ID No. 1858


 


SEQ ID
PYYFTWGK
58-65 for the proteins of SEQ No. 265, 266, 267, 269, 270, 271,


No. 735

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,




285, 286, 287, 288, 289, 290, 291, 292, 295, 297, 298, 300, 302,




303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848,




1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1857, 1859,




1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 57-64 for the




protein of sequence SEQ ID No. 268; 72-79 for the protein of




sequence SEQ ID No. 299; 57-64 for the protein of sequence




SEQ ID No. 1858


 


SEQ ID
AALLR
149-153 for the proteins of SEQ No. 265, 282, 287, 297, 298,


No.

1852, 1853, 1855


1929


 


SEQ ID
ADSIINGNGSDSK
300-312 for the proteins of SEQ No. 267, 1847


No.


1930


 


SEQ ID
ADSIINGSDNK
300-310 for the proteins of SEQ No. 275, 1849; 299-309 for the


No.

protein of sequence SEQ ID No. 268


1931


 


SEQ ID
AELLR
149-153 for the protein of SEQ No. 288


No.


1932


 


SEQ ID
ALQQAISLTHK
270-280 for the proteins of SEQ No. 262, 293, 294, 1860, 1861


No.


1933


 


SEQ ID
AVHVSPGQLDAEAYGVK
228-244 for the proteins of SEQ No. 273, 297, 1855


No.


1934


 


SEQ ID
DYACGYR
218-224 for the protein of SEQ No. 281


No.


1935


 


SEQ ID
DYALGYR
218-224 for the protein of SEQ No. 306


No.


1936


 


SEQ ID
EDKPIR
230-235 for the proteins of SEQ No. 262, 263, 264, 293, 294,


No.

301, 1844, 1845, 1860, 1861, 1863


1937


 


SEQ ID
EGKPVHASPGQLDAEAYGVK
239-258 for the protein of SEQ No. 299


No.


1938


 


SEQ ID
EGKPVHGSPGQLDAEAYGVK
225-244 for the protein of SEQ No. 278


No.


1939


 


SEQ ID
EGKPVHVSPEQLDAEAYGVK
225-244 for the protein of SEQ No. 283


No.


1940


 


SEQ ID
EGKPVHVSPGK
225-235 for the protein of SEQ No. 269


No.


1941


 


SEQ ID
EGKPVHVSPGQFDAEAYGVK
225-244 for the protein of SEQ No. 291


No.


1942


 


SEQ ID
EGKPVHVSPGQLDAEAYCVK
225-244 for the proteins of SEQ No. 1856


No.


1943


 


SEQ ID
EGKPVHVSPGQLDAEAYGVK
225-244 for the proteins of SEQ No. 265, 266, 267, 270, 272,


No.

275, 277, 279, 280, 281, 282, 284, 285, 286, 288, 290, 292, 295,


1944

296, 298, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310,




1846, 1847, 1848, 1849, 1850, 1851, 1853, 1854, 1857, 1859,




1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 224-243 for




the protein of sequence SEQ ID No. 268; 224-243 for the




protein of sequence SEQ ID No. 1858


 


SEQ ID
EGKPVHVSPGQLDAGAYGVK
225-244 for the protein of SEQ No. 271


No.


1945


 


SEQ ID
EGKPVHVSPGQLNAEAYGVK
225-244 for the protein of SEQ No. 311


No.


1946


 


SEQ ID
EGKPVHVSPGR
225-235 for the protein of SEQ No. 276


No.


1947


 


SEQ ID
EGKPVHVTPGQLDAEAYGVK
225-244 for the proteins of SEQ No. 287, 1852


No.


1948


 


SEQ ID
EGKPVYVSPGQLDAEAYGVK
225-244 for the protein of SEQ No. 274


No.


1949


 


SEQ ID
ESGAGVSEQTLFEIGSVSK
73-91 for the proteins of SEQ No. 263, 264, 301, 1844, 1845,


No.

1863


1950


 


SEQ ID
ESGASVSEQTLFDIGSVSK
73-91 for the proteins of SEQ No. 293, 294, 1860, 1861


No.


1951


 


SEQ ID
ESGASVSEQTLFEIGSVSK
73-91 for the protein of SEQ No. 262


No.


1952


 


SEQ ID
FSDPVTK
105-111 for the protein of SEQ No. 307


No.


1953


 


SEQ ID
FYQNWQPQWAPGAK
154-167 for the proteins of SEQ No. 265, 295, 296, 297, 1855


No.


1954


 


SEQ ID
FYQNWQPQWTPGAK
154-167 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No.

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,


1955

285, 286, 287, 288, 289, 290, 291, 292, 298, 300, 302, 303, 304,




305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849,




1850, 1851, 1852, 1853, 1854, 1856, 1857, 1859, 1862, 1864,




1865, 1866, 1867, 1868, 1869, 1870; 153-166 for the protein of




sequence SEQ ID No. 268; 168-181 for the protein of sequence




SEQ ID No. 299; 153-166 for the protein of sequence SEQ ID




No. 1858


 


SEQ ID
IPDDVR
141-146 for the proteins of SEQ No. 266, 267, 269, 270, 271,


No.

273, 274, 275, 276, 278, 279, 281, 283, 284, 285, 286, 289, 290,


1956

291, 292, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311,




1846, 1847, 1848, 1849, 1850, 1851, 1854, 1856, 1857, 1859,




1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 155-160 for




the protein of sequence SEQ ID No. 299; 140-145 for the




protein of sequence SEQ ID No. 1858


 


SEQ ID
LAHTWIK
204-210 for the protein of SEQ No. 297


No.


1957


 


SEQ ID
LAHTWITVPENEQK
204-217 for the protein of SEQ No. 279


No.


1958


 


SEQ ID
LAHTWITVPQSEQK
204-217 for the proteins of SEQ No. 282, 288, 295, 296, 298,


No.

1853


1959


 


SEQ ID
LDAEAYGVK
236-244 for the proteins of SEQ No. 265, 266, 267, 269, 270,


No.

272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,


1960

285, 286, 287, 288, 290, 292, 295, 296, 297, 298, 300, 302, 303,




304, 305, 306, 307, 308, 309, 310, 1846, 1847, 1848, 1849,




1850, 1851, 1852, 1853, 1854, 1855, 1857, 1859, 1862, 1864,




1865, 1866, 1867, 1868, 1869, 1870; 235-243 for the protein of




sequence SEQ ID No. 268; 238-246 for the protein of sequence




SEQ ID No. 289; 250-258 for the protein of sequence SEQ ID




No. 299; 235-243 for the protein of sequence SEQ ID No. 1858


 


SEQ ID
LLHLATYTAGGLPLK
126-140 for the proteins of SEQ No. 1870


No.


1961


 


SEQ ID
LLHLATYTAGGLPLQFPDDVR
126-146 for the protein of SEQ No. 277


No.


1962


 


SEQ ID
LYANSSIGLFAALAVK
169-184 for the protein of SEQ No. 285


No.


1963


 


SEQ ID
LYANSSIGLFGALVVK
169-184 for the protein of SEQ No. 288


No.


1964


 


SEQ ID
LYANSSIGLFGELAVK
169-184 for the proteins of SEQ No. 269, 275, 277, 305, 1849,


No.

1866


1965


 


SEQ ID
LYANSSIGLFGTLAVK
169-184 for the protein of SEQ No. 282


No.


1966


 


SEQ ID
LYANSSIGLFSALAVK
169-184 for the proteins of SEQ No. 1859


No.


1967


 


SEQ ID
LYSNSSIGLFGALAVK
169-184 for the proteins of SEQ No. 304, 310, 1865, 1869,


No.

1870


1968


 


SEQ ID
NYAWGYR
218-224 for the proteins of SEQ No. 288, 298, 1853


No.


1969


 


SEQ ID
NYPIPAR
363-369 for the proteins of SEQ No. 262, 293, 294, 1860, 1861


No.


1970


 


SEQ ID
NYPNEAR
363-369 for the proteins of SEQ No. 301, 1863


No.


1971


 


SEQ ID
NYPNPVR
363-369 for the proteins of SEQ No. 304, 308, 311, 1865, 1867


No.


1972


 


SEQ ID
SICCALLLTASFSTFAAAK
5-23 for the proteins of SEQ No. 288, 1853


No.


1973


 


SEQ ID
SICCALLLTASFSTFAATK
5-23 for the protein of SEQ No. 298


No.


1974


 


SEQ ID
SLCCALLLTAPLSTFAAAK
5-23 for the protein of SEQ No. 297


No.


1975


 


SEQ ID
SLCCALLLTASFSTFASAK
5-23 for the proteins of SEQ No. 265, 296


No.


1976


 


SEQ ID
SLCCALLLTASLSTFAAAK
5-23 for the proteins of SEQ No. 1855


No.


1977


 


SEQ ID
SNVTDMAR
245-252 for the proteins of SEQ No. 265, 287, 296, 1852


No.


1978


 


SEQ ID
SYPNPIR
363-369 for the protein of SEQ No. 295


No.


1979


 


SEQ ID
TALLHFYQNWQPQWAPGAK
149-167 for the proteins of SEQ No. 295, 296


No.


1980


 


SEQ ID
TDSIINGSDSK
300-310 for the proteins of SEQ No. 292, 1854


No.


1981


 


SEQ ID
TFIGVLGGDAIAR
88-100 for the proteins of SEQ No. 1857


No.


1982


 


SEQ ID
TFNGVLGGDCIAR
88-100 for the protein of SEQ No. 279


No.


1983


 


SEQ ID
TFNGVLGGEAIAR
88-100 for the protein of SEQ No. 290


No.


1984


 


SEQ ID
TGSTVGFGSYVAFVPEK
336-352 for the proteins of SEQ No. 1870


No.


1985


 


SEQ ID
TGYTGGFGSYVAFVPEK
336-352 for the protein of SEQ No. 282


No.


1986


 


SEQ ID
TLQQGIELAQSR
267-278 for the proteins of SEQ No. 282, 288, 298, 1853


No.


1987


 


SEQ ID
TSSADLLAFVK
250-260 for the proteins of SEQ No. 262, 293, 294, 1860, 1861


No.


1988


 


SEQ ID
TSSADLLR
250-257 for the proteins of SEQ No. 263, 264, 301, 1844, 1845,


No.

1863


1989


 


SEQ ID
TYYFTWGK
58-65 for the protein of SEQ No. 296


No.


1990


 


SEQ ID
VAALPAVEVNPPAPAVK
311-327 for the proteins of SEQ No. 284, 1850


No.


1991


 


SEQ ID
VAFAALPAVEVNPPAPAVK
311-329 for the proteins of SEQ No. 266, 1846


No.


1992


 


SEQ ID
VALAAIPAVEVNPPAPAVK
311-329 for the protein of SEQ No. 295


No.


1993


 


SEQ ID
VALAALHTVEVNPPAPAVK
311-329 for the protein of SEQ No. 287


No.


1994


 


SEQ ID
VALAALPAVEINPPAPAVK
311-329 for the proteins of SEQ No. 309, 1868


No.


1995


 


SEQ ID
VALAALPTVEVNPPAPAVK
311-329 for the proteins of SEQ No. 1852


No.


1996


 


SEQ ID
VAPAVEVNPPAPAVK
311-325 for the proteins of SEQ No. 286, 1851


No.


1997


 


SEQ ID
VEAYWR
370-375 for the proteins of SEQ No. 270, 1848


No.


1998


 


SEQ ID
VILEANPTAAPR
314-325 for the proteins of SEQ No. 262, 263, 293, 301, 1844,


No.

1860, 1863


1999


 


SEQ ID
VPQSEQK
211-217 for the proteins of SEQ No. 282, 288, 295, 296, 297,


No.

298, 1853


2000


 


SEQ ID
VSLEANPTAAPR
314-325 for the proteins of SEQ No. 264, 294, 1845, 1861


No.


2001


 


SEQ ID
WIQVNMDASR
253-262 for the proteins of SEQ No. 287, 1852


No.


2002


 


SEQ ID
WVQANMDASR
253-262 for the protein of SEQ No. 295


No.


2003


 


SEQ ID
WVQVNMDASR
253-262 for the proteins of SEQ No. 265, 273, 296, 297, 1855


No.


2004


 


SEQ ID
YAAALLLTASFSTFAAAK
5-22 for the proteins of SEQ No. 1858


No.


2005


 


SEQ ID
YLPELTGK
112-119 for the proteins of SEQ No. 1852


No.


2006


 


SEQ ID
YWSELTGK
112-119 for the protein of SEQ No. 295


No.


2007









The detection of a mechanism of resistance to cephalosporins induced by the expression of the CTX-M protein is characterised by the detection of at least one peptide belonging to the CTX-M protein and to its different sequence variants SEQ ID No. 351 to SEQ ID No. 445 and SEQ ID No. 1871 to SEQ ID No. 1908.







SEQ ID No. 351:


MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIA


 


VIWPANHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF


 


SEQ ID No. 352:


MMRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGV


 


ALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKKVLSQKVEI


 


KSSDLINYNPITEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARAIGDNTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRNLTLGS


 


ALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIA


 


VIWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY


 


SEQ ID No. 353:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 354:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 355:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 356:


MVTKRMQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTKDNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFAREIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 357:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAGLERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSPAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTVVMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDI


 


AVIWPKDRAPLILVTYFTQPQPKAESRRHVLAS


 


SEQ ID No. 358:


MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPSLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDILASAAKIVTDGL


 


SEQ ID No. 359:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGGYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 360:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 361:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 362:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAKGL


 


SEQ ID No. 363:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 364:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 365:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTETTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 366:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEI


 


KPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 367:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL


 


SEQ ID No. 368:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEI


 


KPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIRAGLPTSWVVGDKTGSGDYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 369:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 370:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYSPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 371:


MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 372:


MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 373:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSCDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 374:


MVKKSLRQFTLMATATVTLLLGSVPLHAQTADVQQKLAELEQQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 375:


MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVA


 


LIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIK


 


SSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKV


 


TAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSA


 


LGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAV


 


IWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY


 


SEQ ID No. 376:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAARIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 377:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGRRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 378:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTNAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 379:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGRRLGV


 


PLIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 380:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


PLIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 381:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTNAVQQKLAALEKSSGGRLGV


 


PLIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 382:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDGTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 383:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEI


 


KPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 384:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEI


 


KPSDLVNYNPIAEKHVNGTMTFGELIAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 385:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTETTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 386:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGGYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF


 


SEQ ID No. 387:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 388:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTESTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 389:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFPMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 390:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVIYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 391:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEQTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 392:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKLLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 393:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 394:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 395:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTETTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 396:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 397:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAENRRDILAAAAKIVTHGF


 


SEQ ID No. 398:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL


 


SEQ ID No. 399:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 400:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTESTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 401:


MVKKSLRQFTLMATATVTLLLGNVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 402:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYSPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 403:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLEQSETQKQLLNQPVEI


 


QPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDHTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 404:


MVKKSLRQFTLMATATVTLLLGSVPLHAQTVDVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDDTFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 405:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 406:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPNAESRRDVLASAAKIVTNGL


 


SEQ ID No. 407:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTELTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 408:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTHVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 409:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVAWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 410:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTPAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 411:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPFAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 412:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRHDVLASAAKIVTDGL


 


SEQ ID No. 413:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 414:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEI


 


KPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 415:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTETTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 416:


MMTQSIRRSMLTVMATLSLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 417:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSCGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 418:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEI


 


KPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQSLRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 419:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRTQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 420:


MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEI


 


KPSDLINYNPIAEKHVNGTMTLGELSAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGN


 


ALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIA


 


VIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 421:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL


 


SEQ ID No. 422:


MMTQSIGRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 423:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 424:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF


 


SEQ ID No. 425:


MVTKRVQRMMSAAAACIPLLLGSPTLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTARAGADVASLRWVMR


 


WAKPSGAVGDVAQRQYDRAAGIRAGLPTSWTVGDKTGSGDYGTTNDIAVI


 


WPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 426:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 427:


MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVA


 


LIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIK


 


SSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKV


 


TAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSA


 


LGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAV


 


IWPEGRAPLILVTYFTQPEQKAENRRDVLAAAAKIVTDGY


 


SEQ ID No. 428:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 429:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYLADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKCWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF


 


SEQ ID No. 430:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


RASDLVNYNPIAEKHVNGTMTLAQLGAGALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF


 


SEQ ID No. 431:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 432:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 433:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 434:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


AQINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


RASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGMPKSWGVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 435:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDFLAAAAKIVTHGF


 


SEQ ID No. 436:


MVTKRVQRMMFAGGAGIPLLLGSAPFYAQTSAGQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 437:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 438:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 439:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDESFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 440:


MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPSLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDILASAAKIVTDGL


 


SEQ ID No. 441:


MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPSLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDILASAAKIVTDGL


 


SEQ ID No. 442:


MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLKALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIQAGLPKSWVVGDKTGSGDYGTTNDIA


 


IIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTRGF


 


SEQ ID No. 443:


MMRKSVRRAILMTTACVSLLLASVPLYAQANDIQQKLAALEKSSGGRLGV


 


ALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKDLLSQRVEI


 


KSSDLINYNPIAEKHVNGTMTLGELSAAALQYSDNTAMNKLIAHLGGPGK


 


VTAFARVIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRNLTLGN


 


ALGDTQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIA


 


VIWPEGRAPLVLVTYFTQPEPKAESRRDVLAAAARIVTDGY


 


SEQ ID No. 444:


MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF


 


SEQ ID No. 445:


MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAALLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIQAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF


 


SEQ ID No. 1871:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1872:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1873:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAKGL


 


SEQ ID No. 1874:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 1875:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 1876:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL


 


SEQ ID No. 1877:


MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVA


 


LIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIK


 


SSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKV


 


TAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSA


 


LGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAV


 


IWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY


 


SEQ ID No. 1878:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 1879:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 1880:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAENRRDILAAAAKIVTHGF


 


SEQ ID No. 1881:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL


 


SEQ ID No. 1882:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 1883:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPNAESRRDVLASAAKIVTNGL


 


SEQ ID No. 1884:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRHDVLASAAKIVTDGL


 


SEQ ID No. 1885:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1886:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKAMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 1887:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL


 


SEQ ID No. 1888:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTQNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1889:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELIAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 1890:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQREQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1891:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQREQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1892:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAENRRDVLASAARIIAEGL


 


SEQ ID No. 1893:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDRTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRHDVLASAARIIAEG


 


SEQ ID No. 1894:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 1895:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEEHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGNL


 


SEQ ID No. 1896:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGQGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1897:


VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVA


 


LINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIK


 


KSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASV


 


TAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKA


 


LGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDRTGSGGYGTTNDIAV


 


IWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT


 


SEQ ID No. 1898:


VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVA


 


LINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRAEIK


 


KSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASV


 


TAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKA


 


LGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAV


 


IWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT


 


SEQ ID No. 1899:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1900:


MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGV


 


ALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKRSETQKQLLNQPVEI


 


KPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGG


 


VTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGH


 


ALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIA


 


VIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL


 


SEQ ID No. 1901:


VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVA


 


LINTADNSRILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIK


 


KSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASV


 


TAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKA


 


LGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAV


 


IWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTK


 


SEQ ID No. 1902:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF


 


SEQ ID No. 1903:


MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVA


 


LIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIK


 


SSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKV


 


TAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSA


 


LGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAV


 


IWPEGRAPLILVTYFTQPEQKAENRRDVLAAAAKIVTDGY


 


SEQ ID No. 1904:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL


 


SEQ ID No. 1905:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF


 


SEQ ID No. 1906:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL


 


SEQ ID No. 1907:


MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK


 


VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGK


 


ALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIA


 


VIWPENHAPLVLVTYFTQPEQKAESRRDFLAAAAKIVTHGF


 


SEQ ID No. 1908:


MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGV


 


ALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEI


 


KKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPAS


 


VTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGK


 


ALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIA


 


VIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 446 to SEQ ID 495 and SEQ ID No. 2008 to SEQ ID No. 2092 as defined hereafter:













Peptide





SEQ ID


Clinical


No.
Amino acid sequence
Position of the peptide in the CTX-M protein
interest







SEQ ID
AGLPK
226-230 for the proteins of SEQ No. 351, 386, 392, 397,
2be


No. 446

415, 416, 419, 422, 424, 429, 430, 432, 435, 439, 442,




444, 445, 1881, 1903, 1906, 1908


 


SEQ ID
AGLPTSWTVGDK
226-237 for the proteins of SEQ No. 355, 356, 360, 361,
2be


No. 447

362, 367, 369, 376, 377, 378, 379, 380, 381, 398, 402,




403, 407, 408, 409, 410, 411, 413, 421, 423, 436, 1872,




1873, 1874, 1877, 1882, 1886, 1888, 1889, 1891, 1892,




1893, 1896, 1897, 1900, 1901; 224-235 for the protein of




sequence SEQ ID No. 425


 


SEQ ID
AIGDETFR
157-164 for the proteins of SEQ No. 353, 355, 359, 360,
2be


No. 448

361, 362, 367, 369, 376, 377, 378, 379, 380, 381, 387,




398, 402, 403, 407, 408, 409, 410, 411, 413, 421, 423,




425, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
ALAETQR
201-207 for the proteins of SEQ No. 351, 386, 392, 397,
2be


No. 449

415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439,




442, 444, 445, 1881, 1903, 1906, 1908


 


SEQ ID
ALGDSQR
201-207 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 450

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405,




406, 412, 417, 426, 431, 433, 437, 438, 440, 441, 1875,




1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895,




1905, 1907, 1909; 200-206 for the protein of sequence




SEQ ID No. 1898; 200-206 for the protein of sequence




SEQ ID No. 1899; 200-206 for the protein of sequence




SEQ ID No. 1902


 


SEQ ID
AMAQTLR
188-194 for the proteins of SEQ No. 352, 353, 354, 355,
2be


No. 451

356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 367,




369, 370, 371, 372, 373, 374, 376, 377, 378, 379, 380,




381, 382, 385, 387, 388, 389, 390, 391, 393, 394, 395,




396, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407,




408, 409, 410, 411, 412, 413, 417, 421, 423, 426, 428,




431, 433, 436, 437, 438, 440, 441, 443, 1872, 1873, 1874,




1875, 1876, 1877, 1879, 1880, 1882, 1883, 1884, 1885,




1886, 1887, 1888, 1889, 1890, 1891, 1892, 1893, 1894,




1895, 1896, 1897, 1900, 1901, 1905, 1907, 1909; 187-193




for the protein of sequence SEQ ID No. 375; 187-193 for




the protein of sequence SEQ ID No. 427; 187-193 for the




protein of sequence SEQ ID No. 1878; 187-193 for the




protein of sequence SEQ ID No. 1898; 187-193 for the




protein of sequence SEQ ID No. 1899; 187-193 for the




protein of sequence SEQ ID No. 1902; 187-193 for the




protein of sequence SEQ ID No. 1904


 


SEQ ID
APLILVTYFTQPQPK
258-272 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 452

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 412,




417, 426, 428, 431, 433, 437, 438, 440, 441, 1875, 1876,




1879, 1880, 1883, 1885, 1887, 1890, 1895, 1905, 1907,




1909; 257-271 for the protein of sequence SEQ ID No.




1898; 257-271 for the protein of sequence SEQ ID No.




1899; 257-271 for the protein of sequence SEQ ID No.




1902


 


SEQ ID
APLVLVTYFTQPQQNAE
258-276 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 453
SR
360, 361, 362, 369, 376, 377, 378, 379, 380, 381, 387,




402, 403, 407, 408, 409, 410, 411, 413, 423, 436, 1872,




1873, 1874, 1886, 1889, 1891, 1892, 1894, 1896, 1897,




1900, 1901; 256-274 for the protein of sequence SEQ ID




No. 425


 


SEQ ID
AQLVTWLK
208-215 for the proteins of SEQ No. 351, 352, 353, 355,
2be


No. 454

356, 359, 360, 361, 362, 367, 369, 376, 377, 378, 379,




380, 381, 386, 387, 392, 397, 398, 402, 403, 407, 408,




410, 411, 413, 415, 416, 421, 422, 423, 424, 428, 429,




430, 432, 434, 435, 436, 439, 442, 443, 444, 445, 1872,




1873, 1874, 1877, 1881, 1882, 1886, 1888, 1889, 1893,




1894, 1896, 1897, 1900, 1901, 1903, 1906, 1908; 207-214




for the protein of sequence SEQ ID No. 375; 207-214 for




the protein of sequence SEQ ID No. 427; 207-214 for the




protein of sequence SEQ ID No. 1878; 207-214 for the




protein of sequence SEQ ID No. 1904


 


SEQ ID
AQLVTWMK
208-215 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 455

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405,




406, 412, 417, 426, 431, 433, 437, 438, 440, 441, 1875,




1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895,




1905, 1907, 1909; 207-214 for the protein of sequence




SEQ ID No. 1898; 207-214 for the protein of sequence




SEQ ID No. 1899; 207-214 for the protein of sequence




SEQ ID No. 1902


 


SEQ ID
DILAAAAK
278-285 for the proteins of SEQ No. 386, 392, 397, 415,
2be


No. 456

416, 419, 422, 424, 432, 434, 439, 1881, 1903, 1906


 


SEQ ID
DTTSPR
182-187 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 457

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405,




406, 412, 417, 426, 431, 433, 437, 438, 440, 441, 1875,




1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895,




1905, 1907, 1909; 181-186 for the protein of sequence




SEQ ID No. 1898; 181-186 for the protein of sequence




SEQ ID No. 1899; 181-186 for the protein of sequence




SEQ ID No. 1902


 


SEQ ID
DTTTPLAMAQTLK
182-194 for the proteins of SEQ No. 351, 386, 392, 397,
2be


No. 458

415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439,




442, 444, 445, 1881, 1903, 1906, 1908


 


SEQ ID
DTTTPR
182-187 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 459

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 398, 402, 403, 407, 408, 409, 410, 411, 413, 421,




423, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
DVLAAAAK
277-284 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 460

1904; 278-285 for the protein of sequence SEQ ID No.




351; 278-285 for the protein of sequence SEQ ID No.




352; 278-285 for the protein of sequence SEQ ID No.




429; 278-285 for the protein of sequence SEQ ID No.




430; 278-285 for the protein of sequence SEQ ID No.




442; 278-285 for the protein of sequence SEQ ID No.




444; 278-285 for the protein of sequence SEQ ID No. 445


 


SEQ ID
DVLASAAK
278-285 for the proteins of SEQ No. 354, 363, 364, 365,
2be


No. 461

370, 371, 372, 373, 374, 382, 385, 388, 389, 390, 391,




393, 394, 395, 396, 399, 400, 401, 404, 405, 406, 412,




417, 426, 428, 431, 433, 437, 438, 1875, 1876, 1879,




1880, 1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907,




1909; 277-284 for the protein of sequence SEQ ID No.




1898; 277-284 for the protein of sequence SEQ ID No.




1899; 277-284 for the protein of sequence SEQ ID No.




1902


 


SEQ ID
DVLASAAR
278-285 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 462

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 398, 402, 403, 407, 408, 409, 410, 411, 413, 421,




423, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901;




276-283 for the protein of sequence SEQ ID No. 425


 


SEQ ID
FAMCSTSK
69-76 for the proteins of SEQ No. 351, 352, 354, 357,
2be


No. 463

358, 363, 364, 365, 366, 368, 370, 371, 372, 373, 374,




382, 383, 384, 385, 386, 388, 390, 391, 392, 393, 394,




395, 396, 397, 399, 400, 401, 404, 405, 406, 412, 414,




415, 416, 417, 418, 419, 420, 422, 424, 426, 429, 430,




431, 432, 433, 434, 435, 437, 438, 439, 440, 441, 442,




443, 444, 445, 1875, 1876, 1879, 1880, 1881, 1883, 1884,




1885, 1887, 1890, 1895, 1903, 1905, 1906, 1907, 1908,




1909; 68-75 for the protein of sequence SEQ ID No. 375;




68-75 for the protein of sequence SEQ ID No. 427; 68-75




for the protein of sequence SEQ ID No. 1878; 68-75 for




the protein of sequence SEQ ID No. 1898; 68-75 for the




protein of sequence SEQ ID No. 1899; 68-75 for the




protein of sequence SEQ ID No. 1902; 68-75 for the




protein of sequence SEQ ID No. 1904


 


SEQ ID
FPMCSTSK
69-76 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 464

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 389, 398, 402, 403, 407, 408, 409, 410, 411, 413,




421, 423, 425, 428, 436, 1872, 1873, 1874, 1877, 1882,




1886, 1888, 1889, 1891, 1892, 1893, 1894, 1896, 1897,




1900, 1901


 


SEQ ID
GNTTGAASIQAGLPASW
216-237 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 465
VVGDK
364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405,




406, 412, 417, 426, 431, 433, 437, 438, 440, 441, 1875,




1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895,




1905, 1907, 1909; 215-236 for the protein of sequence




SEQ ID No. 1899; 215-236 for the protein of sequence




SEQ ID No. 1902


 


SEQ ID
GNTTGAASIQAGLPTSW
215-236 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 466
VVGDK
1904; 216-237 for the protein of sequence SEQ ID No.




352; 216-237 for the protein of sequence SEQ ID No.




366; 216-237 for the protein of sequence SEQ ID No.




383; 216-237 for the protein of sequence SEQ ID No.




384; 216-237 for the protein of sequence SEQ ID No.




414; 216-237 for the protein of sequence SEQ ID No.




418; 216-237 for the protein of sequence SEQ ID No.




420; 216-237 for the protein of sequence SEQ ID No. 443


 


SEQ ID
GNTTGAASIR
216-225 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 467

360, 361, 362, 367, 368, 369, 377, 378, 379, 380, 381,




387, 398, 402, 403, 407, 408, 409, 410, 411, 413, 421,




423, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
GNTTGSASIR
216-225 for the proteins of SEQ No. 351, 386, 392, 397,
2be


No. 468

415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439,




444, 1881, 1903, 1906, 1908


 


SEQ ID
HLLNQR
92-97 for the proteins of SEQ No. 351, 386, 397, 415,
2be


No. 469

416, 419, 422, 424, 429, 430, 432, 434, 435, 439, 442,




444, 445, 1881, 1903, 1906, 1908


 


SEQ ID
LAALEK
36-41 for the proteins of SEQ No. 375, 427, 1878, 1904;
2be


No. 470

37-42 for the proteins of sequence SEQ ID No. 352, 353,




355, 356, 359, 360, 361, 362, 366, 367, 368, 369, 376,




377, 378, 379, 380, 381, 383, 384, 387, 398, 402, 403,




407, 408, 409, 410, 411, 413, 414, 418, 420, 421, 423,




425, 436, 443, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
LAELER
37-42 for the proteins of SEQ No. 358, 363, 364, 365,
2be


No. 471

370, 371, 372, 382, 385, 388, 389, 391, 393, 394, 395,




396, 399, 400, 401, 404, 405, 406, 412, 417, 426, 428,




431, 433, 437, 438, 440, 441, 1875, 1876, 1879, 1880,




1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909;




36-41 for the protein of sequence SEQ ID No. 1898; 36-41




for the protein of sequence SEQ ID No. 1899; 36-41




for the protein of sequence SEQ ID No. 1902


 


SEQ ID
LGVALIDTADNTQVLYR
48-64 for the proteins of SEQ No. 353, 355, 359, 360,
2be


No. 472

361, 362, 367, 369, 376, 377, 378, 387, 398, 402, 403,




407, 409, 410, 411, 413, 421, 423, 425, 436, 1872, 1873,




1874, 1877, 1882, 1886, 1888, 1889, 1891, 1892, 1893,




1894, 1896, 1897, 1900, 1901


 


SEQ ID
LGVALINTADNSQILYR
48-64 for the proteins of SEQ No. 351, 354, 357, 358,
2be


No. 473

363, 364, 365, 370, 371, 372, 373, 374, 382, 385, 386,




388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 399,




400, 401, 404, 405, 406, 412, 415, 416, 417, 419, 422,




424, 426, 428, 431, 432, 433, 435, 437, 438, 439, 440,




441, 442, 444, 445, 1875, 1876, 1879, 1880, 1881, 1883,




1884, 1885, 1887, 1890, 1895, 1903, 1905, 1906, 1907,




1908, 1909; 47-63 for the protein of sequence SEQ ID




No. 1898; 47-63 for the protein of sequence SEQ ID No.




1899


 


SEQ ID
LIAHLGGPDK
141-150 for the proteins of SEQ No. 351, 352, 366, 368,
2be


No. 474

383, 384, 386, 392, 397, 414, 415, 416, 418, 419, 420,




422, 424, 429, 430, 432, 434, 435, 439, 442, 444, 445,




1881, 1903, 1906, 1908; 140-149 for the protein of




sequence SEQ ID No. 375; 140-149 for the protein of




sequence SEQ ID No. 427; 140-149 for the protein of




sequence SEQ ID No. 1878; 140-149 for the protein of




sequence SEQ ID No. 1904


 


SEQ ID
LIAHVGGPASVTAFAR
141-156 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 475

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 399, 400, 401, 404, 405, 406, 412,




417, 433, 437, 440, 441, 1875, 1876, 1879, 1883, 1884,




1885, 1887, 1890, 1895, 1907, 1909; 140-155 for the




protein of sequence SEQ ID No. 1898; 140-155 for the




protein of sequence SEQ ID No. 1899; 140-155 for the




protein of sequence SEQ ID No. 1902


 


SEQ ID
LIAQLGGPGGVTAFAR
141-156 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 476

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 398, 402, 403, 407, 408, 409, 410, 411, 413, 421,




423, 425, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886,




1888, 1889, 1891, 1892, 1893, 1894, 1896, 1900, 1901


 


SEQ ID
NLTLGK
195-200 for the proteins of SEQ No. 351, 354, 357, 358,
2be


No. 477

363, 364, 365, 370, 371, 372, 373, 374, 382, 385, 386,




388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 399,




400, 401, 404, 405, 406, 412, 415, 416, 417, 419, 422,




424, 426, 429, 430, 431, 432, 433, 434, 435, 437, 438,




439, 440, 441, 442, 444, 445, 1875, 1876, 1879, 1880,




1881, 1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905,




1906, 1907, 1908, 1909; 194-199 for the protein of




sequence SEQ ID No. 1898; 194-199 for the protein of




sequence SEQ ID No. 1899; 194-199 for the protein of




sequence SEQ ID No. 1902


 


SEQ ID
QLGDETFR
157-164 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 478

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 405, 406,




412, 417, 426, 431, 433, 437, 438, 440, 441, 1875, 1876,




1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895, 1905,




1907, 1909; 156-163 for the protein of sequence SEQ ID




No. 1898; 156-163 for the protein of sequence SEQ ID




No. 1899; 156-163 for the protein of sequence SEQ ID




No. 1902


 


SEQ ID
QLLNQPVEIK
92-101 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 479

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 398, 402, 407, 408, 409, 410, 411, 413, 421, 423,




425, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
QLTLGHALGETQR
195-207 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 480

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 398, 402, 403, 407, 408, 409, 410, 411, 413, 421,




423, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
QSESDK
86-91 for the proteins of SEQ No. 351, 386, 392, 397,
2be


No. 481

415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439,




442, 444, 445, 1881, 1903, 1906, 1908


 


SEQ ID
QSETQK
85-90 for the proteins of SEQ No. 375, 427, 1878, 1904;
2be


No. 482

86-91 for the protein of sequence SEQ ID No. 352; 86-91




for the protein of sequence SEQ ID No. 353; 86-91 for the




protein of sequence SEQ ID No. 355; 86-91 for the




protein of sequence SEQ ID No. 356; 86-91 for the




protein of sequence SEQ ID No. 359; 86-91 for the




protein of sequence SEQ ID No. 360; 86-91 for the




protein of sequence SEQ ID No. 361; 86-91 for the




protein of sequence SEQ ID No. 362; 86-91 for the




protein of sequence SEQ ID No. 366; 86-91 for the




protein of sequence SEQ ID No. 367; 86-91 for the




protein of sequence SEQ ID No. 368; 86-91 for the




protein of sequence SEQ ID No. 369; 86-91 for the




protein of sequence SEQ ID No. 376; 86-91 for the




protein of sequence SEQ ID No. 377; 86-91 for the




protein of sequence SEQ ID No. 378; 86-91 for the




protein of sequence SEQ ID No. 379; 86-91 for the




protein of sequence SEQ ID No. 380; 86-91 for the




protein of sequence SEQ ID No. 381; 86-91 for the




protein of sequence SEQ ID No. 383; 86-91 for the




protein of sequence SEQ ID No. 384; 86-91 for the




protein of sequence SEQ ID No. 387; 86-91 for the




protein of sequence SEQ ID No. 398; 86-91 for the




protein of sequence SEQ ID No. 402; 86-91 for the




protein of sequence SEQ ID No. 403; 86-91 for the




protein of sequence SEQ ID No. 407; 86-91 for the




protein of sequence SEQ ID No. 408; 86-91 for the




protein of sequence SEQ ID No. 409; 86-91 for the




protein of sequence SEQ ID No. 410; 86-91 for the




protein of sequence SEQ ID No. 411; 86-91 for the




protein of sequence SEQ ID No. 413; 86-91 for the




protein of sequence SEQ ID No. 414; 86-91 for the




protein of sequence SEQ ID No. 418; 86-91 for the




protein of sequence SEQ ID No. 420; 86-91 for the




protein of sequence SEQ ID No. 421; 86-91 for the




protein of sequence SEQ ID No. 423; 86-91 for the




protein of sequence SEQ ID No. 425; 86-91 for the




protein of sequence SEQ ID No. 428; 86-91 for the




protein of sequence SEQ ID No. 436; 86-91 for the




protein of sequence SEQ ID No. 443; 86-91 for the




protein of sequence SEQ ID No. 1872; 86-91 for the




protein of sequence SEQ ID No. 1873; 86-91 for the




protein of sequence SEQ ID No. 1874; 86-91 for the




protein of sequence SEQ ID No. 1877; 86-91 for the




protein of sequence SEQ ID No. 1882; 86-91 for the




protein of sequence SEQ ID No. 1886; 86-91 for the




protein of sequence SEQ ID No. 1888; 86-91 for the




protein of sequence SEQ ID No. 1889; 86-91 for the




protein of sequence SEQ ID No. 1891; 86-91 for the




protein of sequence SEQ ID No. 1892; 86-91 for the




protein of sequence SEQ ID No. 1893; 86-91 for the




protein of sequence SEQ ID No. 1894; 86-91 for the




protein of sequence SEQ ID No. 1896; 86-91 for the




protein of sequence SEQ ID No. 1897; 86-91 for the




protein of sequence SEQ ID No. 1900


 


SEQ ID
QSGGR
43-47 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 483

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405,




406, 412, 417, 426, 428, 431, 433, 437, 438, 440, 441,




1875, 1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890,




1895, 1905, 1907, 1909; 42-46 for the protein of sequence




SEQ ID No. 1898; 42-46 for the protein of sequence SEQ




ID No. 1899; 42-46 for the protein of sequence SEQ ID




No. 1902


 


SEQ ID
SDLVNYNPIAEK
103-114 for the proteins of SEQ No. 351, 354, 357, 358,
2be


No. 484

363, 364, 365, 371, 372, 373, 374, 382, 384, 385, 386,




388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 399,




400, 401, 404, 405, 406, 412, 415, 416, 417, 419, 422,




424, 426, 429, 430, 431, 432, 433, 434, 435, 437, 438,




439, 440, 441, 442, 444, 445, 1875, 1876, 1879, 1880,




1881, 1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905,




1906, 1907, 1908, 1909; 102-113 for the protein of




sequence SEQ ID No. 1898; 102-113 for the protein of




sequence SEQ ID No. 1899; 102-113 for the protein of




sequence SEQ ID No. 1902


 


SEQ ID
SESEPNLLNQR
87-97 for the proteins of SEQ No. 354, 357, 363, 364,
2be


No. 485

365, 370, 371, 372, 373, 374, 382, 385, 388, 389, 390,




391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 406,




412, 417, 426, 431, 433, 437, 438, 1875, 1876, 1879,




1880, 1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907,




1909; 86-96 for the protein of sequence SEQ ID No.




1898; 86-96 for the protein of sequence SEQ ID No.




1899; 86-96 for the protein of sequence SEQ ID No. 1902


 


SEQ ID
SLGDETFR
157-164 for the proteins of SEQ No. 351, 386, 392, 397,
2be


No. 486

415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 442,




444, 445, 1881, 1903, 1906, 1908


 


SEQ ID
SSGGR
43-47 for the proteins of SEQ No. 351, 352, 353, 355,
2be


No. 487

356, 359, 360, 361, 362, 366, 367, 368, 369, 376, 378,




380, 381, 383, 384, 386, 387, 392, 397, 398, 402, 403,




407, 408, 409, 410, 411, 413, 414, 415, 416, 418, 419,




420, 421, 422, 423, 424, 425, 429, 430, 432, 434, 435,




436, 439, 442, 443, 444, 445, 1872, 1873, 1874, 1877,




1881, 1882, 1886, 1888, 1889, 1891, 1892, 1893, 1894,




1896, 1897, 1900, 1901, 1903, 1906, 1908; 42-46 for the




protein of sequence SEQ ID No. 375; 42-46 for the




protein of sequence SEQ ID No. 427; 42-46 for the




protein of sequence SEQ ID No. 1878; 42-46 for the




protein of sequence SEQ ID No. 1904


 


SEQ ID
SWVVGDK
231-237 for the proteins of SEQ No. 352, 354, 357, 358,
2be


No. 488

363, 364, 365, 366, 368, 370, 371, 372, 373, 374, 382,




383, 384, 385, 386, 388, 389, 390, 391, 392, 393, 394,




395, 396, 397, 399, 400, 401, 404, 405, 406, 412, 414,




415, 416, 417, 418, 419, 420, 422, 424, 426, 428, 431,




432, 433, 435, 437, 438, 439, 440, 441, 442, 443, 445,




1875, 1876, 1879, 1880, 1881, 1883, 1884, 1885, 1887,




1890, 1895, 1903, 1905, 1906, 1907, 1908, 1909; 230-236




for the protein of sequence SEQ ID No. 375; 230-236 for




the protein of sequence SEQ ID No. 427; 230-236 for the




protein of sequence SEQ ID No. 1878; 230-236 for the




protein of sequence SEQ ID No. 1899; 230-236 for the




protein of sequence SEQ ID No. 1902; 230-236 for the




protein of sequence SEQ ID No. 1904


 


SEQ ID
TEPTLNTAIPGDPR
168-181 for the proteins of SEQ No. 351, 352, 353, 354,
2be


No. 489

355, 356, 357, 358, 359, 360, 362, 363, 364, 366, 367,




368, 369, 370, 371, 372, 373, 374, 376, 377, 378, 379,




380, 381, 382, 383, 384, 386, 387, 389, 390, 392, 393,




394, 396, 397, 398, 399, 401, 402, 403, 404, 405, 406,




408, 409, 410, 411, 412, 413, 414, 416, 417, 418, 419,




420, 422, 423, 424, 425, 426, 428, 431, 432, 433, 435,




436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 1872,




1874, 1875, 1876, 1877, 1879, 1880, 1881, 1882, 1883,




1884, 1885, 1886, 1887, 1890, 1891, 1892, 1893, 1894,




1895, 1896, 1897, 1900, 1901, 1903, 1905, 1906, 1907,




1908, 1909; 167-180 for the protein of sequence SEQ ID




No. 375; 167-180 for the protein of sequence SEQ ID No.




427; 167-180 for the protein of sequence SEQ ID No.




1878; 167-180 for the protein of sequence SEQ ID No.




1898; 167-180 for the protein of sequence SEQ ID No.




1899; 167-180 for the protein of sequence SEQ ID No.




1902; 167-180 for the protein of sequence SEQ ID No.




1904


 


SEQ ID
TGSGDYGTTNDIAVIWPK
238-255 for the proteins of SEQ No. 354, 357, 358, 364,
2be


No. 490

365, 372, 374, 382, 385, 388, 391, 395, 396, 400, 401,




404, 405, 426, 431, 433, 441, 1876, 1880, 1895, 1905,




1907


 


SEQ ID
TGSGDYGTTNDIAVIWP
238-257 for the proteins of SEQ No. 353, 355, 356, 360,
2be


No. 491
QGR
361, 362, 367, 376, 377, 378, 379, 380, 381, 387, 398,




402, 403, 407, 408, 409, 410, 411, 413, 421, 436, 1872,




1873, 1874, 1877, 1882, 1886, 1888, 1893, 1894, 1896,




1897, 1900, 1901; 236-255 for the protein of sequence




SEQ ID No. 425


 


SEQ ID
TGSGGYGTTNDIAVIWPK
238-255 for the proteins of SEQ No. 363, 370, 371, 389,
2be


No. 492

390, 393, 394, 399, 406, 412, 428, 437, 438, 440, 1875,




1879, 1883, 1884, 1885, 1887, 1890, 1909; 237-254 for




the protein of sequence SEQ ID No. 1898; 237-254 for




the protein of sequence SEQ ID No. 1899; 237-254 for




the protein of sequence SEQ ID No. 1902


 


SEQ ID
VMAAAAVLK
77-85 for the proteins of SEQ No. 351, 352, 353, 354,
2be


No. 493

355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 367,




368, 369, 370, 371, 372, 373, 374, 376, 377, 378, 379,




380, 381, 382, 383, 384, 385, 386, 389, 391, 392, 397,




400, 401, 402, 404, 405, 408, 409, 410, 411, 412, 415,




416, 417, 419, 420, 421, 422, 424, 425, 426, 428, 429,




430, 432, 433, 434, 435, 436, 437, 439, 440, 442, 443,




444, 1872, 1873, 1874, 1875, 1876, 1877, 1881, 1885,




1888, 1889, 1890, 1891, 1893, 1894, 1896, 1897, 1900,




1901, 1903, 1906, 1907, 1908, 1909; 76-84 for the protein




of sequence SEQ ID No. 375; 76-84 for the protein of




sequence SEQ ID No. 427; 76-84 for the protein of




sequence SEQ ID No. 1878; 76-84 for the protein of




sequence SEQ ID No. 1898; 76-84 for the protein of




sequence SEQ ID No. 1899; 76-84 for the protein of




sequence SEQ ID No. 1902; 76-84 for the protein of




sequence SEQ ID No. 1904


 


SEQ ID
VMAVAAVLK
77-85 for the proteins of SEQ No. 365, 366, 387, 388,
2be


No. 494

390, 393, 394, 395, 396, 398, 399, 406, 407, 413, 414,




418, 423, 431, 438, 441, 1879, 1880, 1882, 1883, 1884,




1886, 1892, 1895, 1905


 


SEQ ID
VTAFAR
151-156 for the proteins of SEQ No. 351, 352, 353, 354,
2be


No. 495

355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365,




366, 367, 368, 369, 370, 371, 372, 373, 374, 376, 377,




378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388,




389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399,




400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410,




411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421,




422, 423, 424, 425, 426, 428, 429, 430, 431, 432, 433,




434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444,




445, 1872, 1873, 1874, 1875, 1876, 1877, 1879, 1880,




1881, 1882, 1883, 1884, 1885, 1886, 1887, 1888, 1889,




1890, 1891, 1892, 1893, 1894, 1895, 1896, 1897, 1900,




1901, 1903, 1905, 1906, 1907, 1908, 1909; 150-155 for




the protein of sequence SEQ ID No. 375; 150-155 for the




protein of sequence SEQ ID No. 427; 150-155 for the




protein of sequence SEQ ID No. 1878; 150-155 for the




protein of sequence SEQ ID No. 1898; 150-155 for the




protein of sequence SEQ ID No. 1899; 150-155 for the




protein of sequence SEQ ID No. 1902; 150-155 for the




protein of sequence SEQ ID No. 1904


 


SEQ ID
AAGIR
219-223 for the protein of SEQ No. 425
2be


No. 2008


 


SEQ ID
AGADVASLR
188-196 for the protein of SEQ No. 425
2be


No. 2009


 


SEQ ID
AGLPASWVVGDK
226-237 for the proteins of SEQ No. 354, 357, 358, 363,
2be


No. 2010

364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389,




390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405,




406, 412, 417, 426, 428, 431, 433, 437, 438, 440, 441,




1875, 1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890,




1895, 1905, 1907, 1909; 225-236 for the protein of




sequence SEQ ID No. 1899; 225-236 for the protein of




sequence SEQ ID No. 1902


 


SEQ ID
AGLPTSWTAGDK
226-237 for the proteins of SEQ No. 353, 359, 387
2be


No. 2011


 


SEQ ID
AGLPTSWTVGDR
226-237 for the proteins of SEQ No. 1894
2be


No. 2012


 


SEQ ID
AGLPTSWVVGDK
225-236 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 2013

1904; 226-237 for the protein of sequence SEQ ID No.




352; 226-237 for the protein of sequence SEQ ID No.




366; 226-237 for the protein of sequence SEQ ID No.




368; 226-237 for the protein of sequence SEQ ID No.




383; 226-237 for the protein of sequence SEQ ID No.




384; 226-237 for the protein of sequence SEQ ID No.




414; 226-237 for the protein of sequence SEQ ID No.




418; 226-237 for the protein of sequence SEQ ID No.




420; 226-237 for the protein of sequence SEQ ID No. 443


 


SEQ ID
AGMPK
226-230 for the protein of SEQ No. 434
2be


No. 2014


 


SEQ ID
AIGDDTFR
156-163 for the proteins of SEQ No. 375, 427, 1878, 1904
2be


No. 2015


 


SEQ ID
AIGDNTFR
157-164 for the protein of SEQ No. 352
2be


No. 2016


 


SEQ ID
AMAVAAVLK
77-85 for the proteins of SEQ No. 1887
2be


No. 2017


 


SEQ ID
APLILVIYFTQPQPK
258-272 for the protein of SEQ No. 390
2be


No. 2018


 


SEQ ID
APLILVTYFTQPEQK
257-271 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 2019

1904; 258-272 for the protein of sequence SEQ ID No.




352


 


SEQ ID
APLILVTYFTQPQPNAESR
258-276 for the proteins of SEQ No. 406, 1884
2be


No. 2020


 


SEQ ID
APLVLVTYFTQPEPK
258-272 for the protein of SEQ No. 443
2be


No. 2021


 


SEQ ID
APLVLVTYFTQPQQNAE
258-276 for the proteins of SEQ No. 1893
2be


No. 2022
NR


 


SEQ ID
APLVLVTYFTQPQQNAER
258-275 for the proteins of SEQ No. 367, 398, 421, 1877,
2be


No. 2023

1882, 1888


 


SEQ ID
APLVLVTYFTQSEPK
258-272 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2024

414, 418, 420


 


SEQ ID
AQLVAWLK
208-215 for the protein of SEQ No. 409
2be


No. 2025


 


SEQ ID
AQLVMWLK
208-215 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2026

414, 418, 420


 


SEQ ID
ASDLVNYNPIAEK
102-114 for the proteins of SEQ No. 429, 430, 434
2be


No. 2027


 


SEQ ID
CWVVGDK
231-237 for the protein of SEQ No. 429
2be


No. 2028


 


SEQ ID
DFLAAAAK
278-285 for the proteins of SEQ No. 435, 1908
2be


No. 2029


 


SEQ ID
DILASAAK
278-285 for the proteins of SEQ No. 358, 440, 441
2be


No. 2030


 


SEQ ID
DLLSQR
92-97 for the protein of SEQ No. 443
2be


No. 2031


 


SEQ ID
DNTQVLYR
57-64 for the proteins of SEQ No. 353, 355, 356, 359,
2be


No. 2032

360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381,




387, 398, 402, 403, 407, 409, 410, 411, 413, 421, 423,




425, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,




1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901


 


SEQ ID
DTTTAR
182-187 for the protein of SEQ No. 425
2be


No. 2033


 


SEQ ID
DTTTPLAMAQALR
182-194 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2034

414, 420


 


SEQ ID
DTTTPLAMAQSLR
182-194 for the protein of SEQ No. 418
2be


No. 2035


 


SEQ ID
DTTTPLAMAQTLR
181-193 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 2036

1904; 182-194 for the protein of sequence SEQ ID No.




352; 182-194 for the protein of sequence SEQ ID No. 443


 


SEQ ID
DVLAAAAR
278-285 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2037

414, 418, 420, 443


 


SEQ ID
EIGDETFR
157-164 for the protein of SEQ No. 356
2be


No. 2038


 


SEQ ID
EQLVTWLK
208-215 for the proteins of SEQ No. 1891, 1892
2be


No. 2039


 


SEQ ID
GLLSQR
92-97 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2040

414, 418, 420


 


SEQ ID
GNTTGAAR
216-223 for the protein of SEQ No. 376
2be


No. 2041


 


SEQ ID
GNTTGSASIQAGLPK
216-230 for the proteins of SEQ No. 442, 445
2be


No. 2042


 


SEQ ID
HDVLASAAK
277-285 for the proteins of SEQ No. 412, 1885
2be


No. 2043


 


SEQ ID
HDVLASAAR
277-285 for the proteins of SEQ No. 1894
2be


No. 2044


 


SEQ ID
HLTLGSALGETQR
194-206 for the proteins of SEQ No. 375, 427, 1878, 1904
2be


No. 2045


 


SEQ ID
LAELEQQSGGR
37-47 for the proteins of SEQ No. 354, 373, 374, 390
2be


No. 2046


 


SEQ ID
LAGLER
37-42 for the protein of SEQ No. 357
2be


No. 2047


 


SEQ ID
LDGTEPTLNTAIPGDPR
165-181 for the protein of SEQ No. 382
2be


No. 2048


 


SEQ ID
LGVALIDTADNAQTLYR
47-63 for the proteins of SEQ No. 375, 427, 1878, 1904;
2be


No. 2049

48-64 for the protein of sequence SEQ ID No. 352


 


SEQ ID
LGVALIDTADNTHVLYR
48-64 for the protein of SEQ No. 408
2be


No. 2050


 


SEQ ID
LGVALIDTK
48-56 for the protein of SEQ No. 356
2be


No. 2051


 


SEQ ID
LGVALINTADNSQILYLAD
48-68 for the protein of SEQ No. 429
2be


No. 2052
ER


 


SEQ ID
LGVALINTADNSQILYVA
48-68 for the protein of SEQ No. 430
2be


No. 2053
DER


 


SEQ ID
LGVALINTADNSR
47-59 for the proteins of SEQ No. 1902
2be


No. 2054


 


SEQ ID
LGVALINTADNTQTLYR
48-64 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2055

414, 418, 420, 443


 


SEQ ID
LGVAQINTADNSQILYVA
48-68 for the protein of SEQ No. 434
2be


No. 2056
DER


 


SEQ ID
LGVPLIDTADNTQVLYR
48-64 for the proteins of SEQ No. 379, 380, 381
2be


No. 2057


 


SEQ ID
LIAHLGGPGK
141-150 for the protein of SEQ No. 443
2be


No. 2058


 


SEQ ID
LIAQLGGQGGVTAFAR
141-156 for the proteins of SEQ No. 1897
2be


No. 2059


 


SEQ ID
LISHVGGPASVTAFAR
141-156 for the proteins of SEQ No. 395, 396, 426, 431,
2be


No. 2060

438, 1880, 1905


 


SEQ ID
LLLNQR
92-97 for the protein of SEQ No. 392
2be


No. 2061


 


SEQ ID
NLTLGNALGDTQR
195-207 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2062

414, 418, 420, 443


 


SEQ ID
NLTLGSALGETQR
195-207 for the protein of SEQ No. 352
2be


No. 2063


 


SEQ ID
NVLSQK
91-96 for the proteins of SEQ No. 375, 427, 1878, 1904
2be


No. 2064


 


SEQ ID
QLGDDTFR
157-164 for the protein of SEQ No. 404
2be


No. 2065


 


SEQ ID
SDLVNYSPIAEK
103-114 for the protein of SEQ No. 370
2be


No. 2066


 


SEQ ID
SESEPSLLNQR
87-97 for the proteins of SEQ No. 358, 440, 441
2be


No. 2067


 


SEQ ID
SETQK
86-90 for the proteins of SEQ No. 375, 427, 1878, 1904;
2be


No. 2068

87-91 for the protein of sequence SEQ ID No. 352; 87-91




for the protein of sequence SEQ ID No. 353; 87-91 for the




protein of sequence SEQ ID No. 355; 87-91 for the




protein of sequence SEQ ID No. 356; 87-91 for the




protein of sequence SEQ ID No. 359; 87-91 for the




protein of sequence SEQ ID No. 360; 87-91 for the




protein of sequence SEQ ID No. 361; 87-91 for the




protein of sequence SEQ ID No. 362; 87-91 for the




protein of sequence SEQ ID No. 366; 87-91 for the




protein of sequence SEQ ID No. 367; 87-91 for the




protein of sequence SEQ ID No. 368; 87-91 for the




protein of sequence SEQ ID No. 369; 87-91 for the




protein of sequence SEQ ID No. 376; 87-91 for the




protein of sequence SEQ ID No. 377; 87-91 for the




protein of sequence SEQ ID No. 378; 87-91 for the




protein of sequence SEQ ID No. 379; 87-91 for the




protein of sequence SEQ ID No. 380; 87-91 for the




protein of sequence SEQ ID No. 381; 87-91 for the




protein of sequence SEQ ID No. 383; 87-91 for the




protein of sequence SEQ ID No. 384; 87-91 for the




protein of sequence SEQ ID No. 387; 87-91 for the




protein of sequence SEQ ID No. 398; 87-91 for the




protein of sequence SEQ ID No. 402; 87-91 for the




protein of sequence SEQ ID No. 403; 87-91 for the




protein of sequence SEQ ID No. 407; 87-91 for the




protein of sequence SEQ ID No. 408; 87-91 for the




protein of sequence SEQ ID No. 409; 87-91 for the




protein of sequence SEQ ID No. 410; 87-91 for the




protein of sequence SEQ ID No. 411; 87-91 for the




protein of sequence SEQ ID No. 413; 87-91 for the




protein of sequence SEQ ID No. 414; 87-91 for the




protein of sequence SEQ ID No. 418; 87-91 for the




protein of sequence SEQ ID No. 420; 87-91 for the




protein of sequence SEQ ID No. 421; 87-91 for the




protein of sequence SEQ ID No. 423; 87-91 for the




protein of sequence SEQ ID No. 425; 87-91 for the




protein of sequence SEQ ID No. 428; 87-91 for the




protein of sequence SEQ ID No. 436; 87-91 for the




protein of sequence SEQ ID No. 443; 87-91 for the




protein of sequence SEQ ID No. 1872; 87-91 for the




protein of sequence SEQ ID No. 1873; 87-91 for the




protein of sequence SEQ ID No. 1874; 87-91 for the




protein of sequence SEQ ID No. 1877; 87-91 for the




protein of sequence SEQ ID No. 1882; 87-91 for the




protein of sequence SEQ ID No. 1886; 87-91 for the




protein of sequence SEQ ID No. 1888; 87-91 for the




protein of sequence SEQ ID No. 1889; 87-91 for the




protein of sequence SEQ ID No. 1891; 87-91 for the




protein of sequence SEQ ID No. 1892; 87-91 for the




protein of sequence SEQ ID No. 1893; 87-91 for the




protein of sequence SEQ ID No. 1894; 87-91 for the




protein of sequence SEQ ID No. 1896; 87-91 for the




protein of sequence SEQ ID No. 1897; 87-91 for the




protein of sequence SEQ ID No. 1900; 87-91 for the




protein of sequence SEQ ID No. 1901


 


SEQ ID
SLGDESFR
157-164 for the protein of SEQ No. 439
2be


No. 2069


 


SEQ ID
SSDLINYNPIAEK
101-113 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 2070

1904; 102-114 for the protein of sequence SEQ ID No.




443


 


SEQ ID
SSDLINYNPITEK
102-114 for the protein of SEQ No. 352
2be


No. 2071


 


SEQ ID
SWGVGDK
231-237 for the proteins of SEQ No. 351, 430, 434, 444
2be


No. 2072


 


SEQ ID
TELTLNTAIPGDPR
168-181 for the protein of SEQ No. 407
2be


No. 2073


 


SEQ ID
TEPTLNSAIPGDPR
168-181 for the proteins of SEQ No. 429, 430, 434
2be


No. 2074


 


SEQ ID
TEPTQNTAIPGDPR
168-181 for the proteins of SEQ No. 1889
2be


No. 2075


 


SEQ ID
TEQTLNTAIPGDPR
168-181 for the protein of SEQ No. 391
2be


No. 2076


 


SEQ ID
TESTLNTAIPGDPR
168-181 for the proteins of SEQ No. 361, 388, 400, 421,
2be


No. 2077

1873, 1888


 


SEQ ID
TETTLNTAIPGDPR
168-181 for the proteins of SEQ No. 365, 385, 395, 415
2be


No. 2078


 


SEQ ID
TGSCDYGTTNDIAVIWPK
238-255 for the protein of SEQ No. 373
2be


No. 2079


 


SEQ ID
TGSCGYGTTNDIAVIWPK
238-255 for the protein of SEQ No. 417
2be


No. 2080


 


SEQ ID
TGSGDYGTTNDIAVIWPE
237-256 for the proteins of SEQ No. 375, 427, 1878,
2be


No. 2081
GR
1904; 238-257 for the protein of sequence SEQ ID No.




352; 238-257 for the protein of sequence SEQ ID No.




368; 238-257 for the protein of sequence SEQ ID No.




383; 238-257 for the protein of sequence SEQ ID No.




414; 238-257 for the protein of sequence SEQ ID No.




418; 238-257 for the protein of sequence SEQ ID No. 443


 


SEQ ID
TGSGGYGTTNDIAVIWPE
238-257 for the proteins of SEQ No. 366, 384, 420
2be


No. 2082
GR


 


SEQ ID
TGSGGYGTTNDIAVIWP
238-257 for the proteins of SEQ No. 359, 369, 423, 1889,
2be


No. 2083
QGR
1891, 1892


 


SEQ ID
TIGDDTFR
157-164 for the proteins of SEQ No. 366, 368, 383, 384,
2be


No. 2084

414, 418, 420


 


SEQ ID
TQLVTWLK
208-215 for the protein of SEQ No. 419
2be


No. 2085


 


SEQ ID
VEIKPSDLINYNPIAEK
98-114 for the proteins of SEQ No. 366, 368, 383, 414,
2be


No. 2086

418, 420


 


SEQ ID
VEIKPSDLVNYNPIAEK
98-114 for the protein of SEQ No. 384
2be


No. 2087


 


SEQ ID
VIGDDTFR
157-164 for the protein of SEQ No. 443
2be


No. 2088


 


SEQ ID
VLSQK
92-96 for the proteins of SEQ No. 375, 427, 1878, 1904;
2be


No. 2089

93-97 for the protein of sequence SEQ ID No. 352


 


SEQ ID
VMAAAALLK
77-85 for the protein of SEQ No. 445
2be


No. 2090


 


SEQ ID
VMAAAAVLEQSETQK
77-91 for the protein of SEQ No. 403
2be


No. 2091


 


SEQ ID
WAKPSGAVGDVAQR
201-214 for the protein of SEQ No. 425
2be


No. 2092









In the clinical interest column, the entry 2be indicates that all of the CTX-M peptides indicates the presence of a beta-lactamase with an extended spectrum (ESBL) capable of hydrolysing penicillins, first-generation cephalosporins such as cephaloridine and cefalotin, and at least one antibiotic from the oxyimino-beta-lactam class such as cefotaxime, ceftazidime or monobactams such as aztreonam.
The detection of a mechanism of resistance to ESBL (extended-spectrum beta-lactamase) cephalosporins, induced by the CTX-M protein is characterised by the detection of at least one resistance-marking 2be peptide chosen from the sequences SEQ ID No. 446 to SEQ ID No. 478, SEQ ID No. 480 to SEQ ID No. 495 and SEQ ID No. 2008 to SEQ ID No. 2092.
The detection of a mechanism of resistance to cephalosporins induced by the expression of the SHV protein is characterised by the detection of at least one peptide belonging to the SHV protein and to its different sequence variants SEQ ID No. 496 to SEQ ID No. 613 and SEQ ID No. 1909 to SEQ ID No. 1919.








SEQ ID No. 496:



KRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 497:


LRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRAD


 


ERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPG


 


DARDTTTPASMAATLRKLLTSQRLSASSQRQLLQWMVDDRVAGPLIRSVLPAGWFI


 


ADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 498:


MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 499:


MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNNAERMVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 500:


MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 501:


MRIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRAD


 


ERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPG


 


DARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFI


 


ADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 502:


MRYARLCIISLLATLPLVVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWR


 


ADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADG


 


MTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAL


 


PGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAG


 


WFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE


 


HWQR


 


SEQ ID No. 503:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 504:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 505:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 506:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAAKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 507:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 508:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 509:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 510:


MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRA


 


DGRFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 511:


MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMISTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMSDNSAANLLLAIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPG


 


DARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFI


 


ADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 512:


MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVEDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 513:


MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQHIAGIGAALIEH


 


WQR


 


SEQ ID No. 514:


MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 515:


MRYIRLCIISLLATLPLAVHASPQPLDQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 516:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWHA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 517:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWHA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAKRNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 518:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMISTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPG


 


DARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFI


 


ADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 519:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYLQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 520:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHFADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLSAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 521:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TIGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 522:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGEFCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 523:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGEFCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAGTLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 524:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAAKLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 525:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATFGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 526:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGLAGLTAFLRQIGDNVTRLDRWETELNEALP


 


ADARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 527:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 528:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 529:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDKVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 530:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETDRWETE


 


LNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSV


 


LPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIG


 


AALIEHWQR


 


SEQ ID No. 531:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 532:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 533:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARATTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 534:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLNSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 535:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARLQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 536:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 537:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 538:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 539:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDGVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 540:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 541:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPDNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 542:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNHKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 543:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 544:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALRGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 545:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDSPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 546:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGKRGARGIVALLGPNNKAERTVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 547:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDSPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 548:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 549:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 550:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGLGAALIEH


 


WQR


 


SEQ ID No. 551:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 552:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLSAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 553:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDGRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 554:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMTATLRKLLTSQRLSARSQRHLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 555:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 556:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 557:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 558:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARGTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 559:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARNTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 560:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALS


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 561:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETERNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 562:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGENVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTNQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 563:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 564:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSVANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTLASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 565:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAVITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 566:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCTAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 567:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 568:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASRTLTAWRAD


 


ERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMGDNSAANLLLRTVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRNVLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 569:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASRTLTAWRAD


 


ERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMSDNSAANLLLRTVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPG


 


DARDTTTPASMAATLRNVLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFI


 


ADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 570:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASSRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 571:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWCA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 572:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMISTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMT


 


VGELCAAAITMSDNSAANLLLAIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPG


 


DARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFI


 


ADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 573:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVALCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 574:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVLLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 575:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAMLARVDAGDKQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 576:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLAIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 577:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 578:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLISQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWF


 


IADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 579:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDARVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 580:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKAGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 581:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 582:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 583:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGGRGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 584:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 585:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 586:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGGNIKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 587:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAELDQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 588:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 589:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASRRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 590:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 591:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 592:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEVLP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 593:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGVTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 594:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPTGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 595:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGSPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 596:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 597:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLTDGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 598:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 599:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQHLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 600:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDKQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGGRGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 601:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGTVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 602:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DQRFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 603:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGSVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 604:


MRYIRLCIISLLATLPLAVHSSPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 605:


MRYIRLCIISLLATLPLTVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 606:


MRYIRLCIISLLATLSLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 607:


MRYIRLCIISLLATMPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWR


 


ADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADG


 


MTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAL


 


PGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAG


 


WFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE


 


HWQR


 


SEQ ID No. 608:


MRYIRLCIISLLAVLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 609:


MRYIRLNIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 610:


MRYIRRCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDMPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 611:


MRYIRRCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 612:


MRYVRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWR


 


ADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADG


 


MTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAL


 


PGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAG


 


WFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE


 


HWQR


 


SEQ ID No. 613:


MRYVRLCIISLLATLPLAVHTSPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWR


 


ADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADG


 


MTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAL


 


PGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAG


 


WFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE


 


HWQR


 


SEQ ID No. 1909:


MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQHIAGIGAALIEH


 


WQR


 


SEQ ID No. 1910:


ALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPA


 


GWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDS


 


SEQ ID No. 1911:


MRYIRLCIISLLAALPLVVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 1912:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAELDQQIAGIGAALIEHW


 


QR


 


SEQ ID No. 1913:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELRAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGTGAAPIEH


 


WQR


 


SEQ ID No. 1914:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLREIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 1915:


MRYIRLCIISLLATLPLAVHASPQPLKQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 1916:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAALTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPHNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 1917:


KRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYSQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 1918:


MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH


 


WQR


 


SEQ ID No. 1919:


MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRA


 


DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGM


 


TVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALP


 


GDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGW


 


FIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAA






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 614 to SEQ ID No. 711 and SEQ ID No. 2093 to SEQ ID No. 2096 as defined hereafter:













Peptide





SEQ ID
Amino acid

Clinical


No.
sequence
Position of the peptide in the SHV protein
interest







SEQ ID
AGAGER
231-236 for the protein of SEQ No. 580
SHV


No. 614


 


SEQ ID
ATTTPASMAATLR
175-187 for the protein of SEQ No. 533
2be


No. 615


 


SEQ ID
CIISLLATLPLAVH
7-30 for the proteins of SEQ No. 496, 497, 498, 499, 500, 503,
SHV


No. 616
ASPQPLEQIK
504, 505, 506, 507, 508, 509, 510, 516, 517, 518, 519, 520,




521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532,




533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544,




545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556,




557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568,




569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580,




581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592,




593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 610,




611, 612, 1913, 1914, 1915, 1917, 1918, 1919, 1920; 6-29 for




the protein of sequence SEQ ID No. 501


 


SEQ ID
DMPASMAER
261-269 for the protein of SEQ No. 610
2b


No. 617


 


SEQ ID
DSPASMAER
261-269 for the proteins of SEQ No. 545, 547
SHV


No. 618


 


SEQ ID
DTLASMAER
261-269 for the protein of SEQ No. 564
SHV


No. 619


 


SEQ ID
DTPASMAER
261-269 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 620

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 546, 548, 549, 550, 551, 552, 553,




554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 565, 566,




567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580,




581, 582, 583, 584, 585, 586, 588, 589, 590, 591, 592, 593,




594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605,




606, 607, 608, 609, 611, 612, 613, 1910, 1912, 1914, 1915,




1916, 1917, 1918, 1919, 1920; 260-268 for the protein of




sequence SEQ ID No. 501; 266-274 for the protein of sequence




SEQ ID No. 530; 260-268 for the protein of sequence SEQ ID




No. 568; 260-268 for the protein of sequence SEQ ID No. 569


 


SEQ ID
DTPASMAK
261-268 for the protein of SEQ No. 517
SHV


No. 621


 


SEQ ID
DTTTPASMAATLR
175-187 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 622

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 524, 525, 526,




527, 528, 529, 531, 532, 534, 535, 536, 537, 538, 539, 540,




541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552,




553, 560, 561, 562, 563, 564, 565, 566, 567, 570, 571, 572,




573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584,




585, 586, 587, 588, 589, 590, 592, 593, 594, 595, 596, 597,




598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609,




610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1917, 1918,




1919, 1920; 174-186 for the protein of sequence SEQ ID No.




501; 180-192 for the protein of sequence SEQ ID No. 530;




174-186 for the protein of sequence SEQ ID No. 568; 174-186




for the protein of sequence SEQ ID No. 569; 8-20 for the




protein of sequence SEQ ID No. 1911


 


SEQ ID
DTTTPASMAGTLR
175-187 for the protein of SEQ No. 523
2b


No. 623


 


SEQ ID
DTTTPASMTATLR
175-187 for the proteins of SEQ No. 554, 555, 556, 557, 591,
SHV


No. 624

1916


 


SEQ ID
FPMISTFK
62-69 for the proteins of SEQ No. 511, 518, 572
2br


No. 625


 


SEQ ID
FPMMSTFK
62-69 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 626

502, 503, 504, 505, 506, 507, 508, 509, 510, 512, 513, 514,




515, 516, 517, 519, 520, 521, 522, 523, 524, 525, 526, 527,




528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551,




552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563,




564, 565, 566, 567, 570, 571, 573, 574, 575, 576, 577, 578,




579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590,




591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602,




603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910,




1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 61-68




for the protein of sequence SEQ ID No. 501; 61-68 for the




protein of sequence SEQ ID No. 568; 61-68 for the protein of




sequence SEQ ID No. 569


 


SEQ ID
GIVALLGGNIK
240-250 for the protein of SEQ No. 586
2b


No. 627


 


SEQ ID
GIVALLGPDNK
240-250 for the protein of SEQ No. 541
SHV


No. 628


 


SEQ ID
GIVALLGPNHK
240-250 for the protein of SEQ No. 542
SHV


No. 629


 


SEQ ID
GIVALLGPNNK
240-250 for the proteins of SEQ No. 496, 497, 498, 500, 502,
SHV


No. 630

503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 543, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554,




555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566,




567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580,




581, 582, 583, 584, 585, 587, 588, 589, 590, 591, 592, 593,




594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605,




606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913,




1914, 1915, 1916, 1918, 1919, 1920; 239-249 for the protein of




sequence SEQ ID No. 501; 245-255 for the protein of sequence




SEQ ID No. 530; 239-249 for the protein of sequence SEQ ID




No. 568; 239-249 for the protein of sequence SEQ ID No. 569;




73-83 for the protein of sequence SEQ ID No. 1911


 


SEQ ID
GIVALLGPNNNAER
240-253 for the protein of SEQ No. 499
2b


No. 631


 


SEQ ID
GIVALR
240-245 for the protein of SEQ No. 544
SHV


No. 632


 


SEQ ID
GPNNK
246-250 for the proteins of SEQ No. 496, 497, 498, 500, 502,
SHV


No. 633

503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553,




554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565,




566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579,




580, 581, 582, 583, 584, 585, 587, 588, 589, 590, 591, 592,




593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604,




605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913,




1914, 1915, 1916, 1918, 1919, 1920; 245-249 for the protein of




sequence SEQ ID No. 501; 251-255 for the protein of sequence




SEQ ID No. 530; 245-249 for the protein of sequence SEQ ID




No. 568; 245-249 for the protein of sequence SEQ ID No. 569;




79-83 for the protein of sequence SEQ ID No. 1911


 


SEQ ID
GTTTPASMAATLR
175-187 for the protein of SEQ No. 558
2be


No. 634


 


SEQ ID
HLADGMTVGELC
108-132 for the protein of SEQ No. 524
SHV


No. 635
AAAITMSDNSAAK


 


SEQ ID
HLLQWMVDDR
202-211 for the protein of SEQ No. 554
SHV


No. 636


 


SEQ ID
IHYLQQDLVDYSP
91-107 for the protein of SEQ No. 519
SHV


No. 637
VSEK


 


SEQ ID
IVVIYLR
254-260 for the proteins of SEQ No. 496, 497, 498, 500, 502,
SHV


No. 638

503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 545, 547, 548, 549, 550, 551, 552,




553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564,




565, 566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 578,




579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590,




591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602,




603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910,




1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 253-259




for the protein of sequence SEQ ID No. 501; 259-265 for




the protein of sequence SEQ ID No. 530; 253-259 for the




protein of sequence SEQ ID No. 568; 253-259 for the protein




of sequence SEQ ID No. 569; 87-93 for the protein of sequence




SEQ ID No. 1911


 


SEQ ID
LCIISLLAALPLAV
6-30 for the proteins of SEQ No. 511, 512, 513, 514, 1910
2b


No. 639
HASPQPLEQIK


 


SEQ ID
LCIISLLATLPLAV
6-30 for the protein of SEQ No. 515
2b


No. 640
HASPQPLDQIK


 


SEQ ID
LCIISLLATLPLAV
6-30 for the proteins of SEQ No. 496, 497, 498, 499, 500, 503,
SHV


No. 641
HASPQPLEQIK
504, 505, 506, 507, 508, 509, 510, 516, 517, 518, 519, 520,




521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532,




533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544,




545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556,




557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568,




569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580,




581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592,




593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 612,




1913, 1914, 1915, 1917, 1918, 1919, 1920; 5-29 for the protein




of sequence SEQ ID No. 501


 


SEQ ID
LCIISLLATLPLAV
6-30 for the protein of SEQ No. 604
SHV


No. 642
HSSPQPLEQIK


 


SEQ ID
LCIISLLATLPLAV
6-30 for the protein of SEQ No. 613
SHV


No. 643
HTSPQPLEQIK


 


SEQ ID
LCIISLLATLPLTV
6-30 for the protein of SEQ No. 605
2b


No. 644
HASPQPLEQIK


 


SEQ ID
LCIISLLATLPLVV
6-30 for the protein of SEQ No. 502
2b


No. 645
HASPQPLEQIK


 


SEQ ID
LCIISLLATLSLAV
6-30 for the protein of SEQ No. 606
2be


No. 646
HASPQPLEQIK


 


SEQ ID
LCIISLLATMPLAV
6-30 for the protein of SEQ No. 607
SHV


No. 647
HASPQPLEQIK


 


SEQ ID
LCIISLLAVLPLAV
6-30 for the protein of SEQ No. 608
2b


No. 648
HASPQPLEQIK


 


SEQ ID
LLISQR
189-194 for the protein of SEQ No. 578
SHV


No. 649


 


SEQ ID
LLLATVGGPAGLT
133-149 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 650
AFLR
502, 503, 505, 506, 507, 508, 509, 510, 512, 513, 514, 515,




516, 517, 518, 519, 521, 522, 523, 524, 527, 528, 529, 530,




531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542,




543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554,




555, 556, 557, 558, 559, 560, 561, 562, 564, 565, 566, 570,




571, 573, 574, 575, 577, 578, 579, 580, 581, 582, 583, 584,




585, 586, 587, 588, 589, 590, 591, 592, 596, 597, 598, 599,




600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611,




612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1918, 1919,




1920


 


SEQ ID
LLNSQR
189-194 for the protein of SEQ No. 534
2be


No. 651


 


SEQ ID
LLTNQR
189-194 for the protein of SEQ No. 562
SHV


No. 652


 


SEQ ID
LLTSQR
189-194 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 653

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,




526, 527, 528, 529, 531, 532, 533, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551,




552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 563, 564,




565, 566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 579,




580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591,




592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603,




604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912,




1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 188-193 for




the protein of sequence SEQ ID No. 501; 194-199 for the




protein of sequence SEQ ID No. 530; 22-27 for the protein of




sequence SEQ ID No. 1911


 


SEQ ID
LNIISLLATLPLAV
6-30 for the protein of SEQ No. 609
2b


No. 654
HASPQPLEQIK


 


SEQ ID
LSASSQR
195-201 for the protein of SEQ No. 497
SHV


No. 655


 


SEQ ID
LSESQLSGR
31-39 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 656

503, 504, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524,




525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536,




537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548,




549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560,




561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 604, 606,




609, 1917, 1918, 1919; 30-38 for the protein of sequence SEQ




ID No. 501


 


SEQ ID
LSESQLSGSVGM
31-51 for the proteins of SEQ No. 505, 506, 507, 508, 509, 510
SHV


No. 657
IEMDLASGR


 


SEQ ID
MVVIYLR
254-260 for the protein of SEQ No. 499
2b


No. 658


 


SEQ ID
NEALPGDAR
166-174 for the proteins of SEQ No. 496, 497, 498, 499, 500,
2be


No. 659

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 523, 524, 525, 527,




528, 529, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542,




543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554,




555, 556, 557, 558, 559, 561, 562, 563, 564, 565, 566, 567,




570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581,




582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 593, 594,




595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606,




607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914,




1915, 1916, 1917, 1918, 1919, 1920; 165-173 for the protein of




sequence SEQ ID No. 501; 171-179 for the protein of sequence




SEQ ID No. 530; 165-173 for the protein of sequence SEQ ID




No. 568; 165-173 for the protein of sequence SEQ ID No. 569


 


SEQ ID
NQHIAGIGAALIE
270-286 for the proteins of SEQ No. 513, 1910
SHV


No. 660
HWQR


 


SEQ ID
NQQIAGIGAALIE
270-286 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 661
HWQR
502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 551, 552,




553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564,




565, 566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 578,




579, 580, 581, 582, 583, 584, 585, 586, 588, 589, 590, 591,




592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603,




604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1912, 1915,




1916, 1917, 1918, 1919; 269-285 for the protein of sequence




SEQ ID No. 501; 275-291 for the protein of sequence SEQ ID




No. 530; 269-285 for the protein of sequence SEQ ID No. 568;




269-285 for the protein of sequence SEQ ID No. 569


 


SEQ ID
NQQIAGLGAALIE
270-286 for the protein of SEQ No. 550
SHV


No. 662
HWQR


 


SEQ ID
NTTTPASMAATLR
175-187 for the protein of SEQ No. 559
2be


No. 663


 


SEQ ID
NVLTSQR
187-193 for the proteins of SEQ No. 568, 569
SHV


No. 664


 


SEQ ID
QIDDNVTR
150-157 for the proteins of SEQ No. 505, 527, 528, 565, 577,
2be


No. 665

601


 


SEQ ID
QIGDK
150-154 for the protein of SEQ No. 529
2b


No. 666


 


SEQ ID
QIGDNVTR
150-157 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 667

502, 503, 504, 506, 507, 508, 509, 510, 511, 512, 513, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541,




542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553,




554, 555, 556, 557, 558, 559, 560, 561, 563, 564, 566, 567,




570, 571, 572, 573, 574, 575, 576, 578, 579, 580, 581, 582,




583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594,




595, 596, 597, 598, 599, 600, 602, 603, 604, 605, 606, 607,




608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1916,




1917, 1918, 1919, 1920; 149-156 for the protein of sequence




SEQ ID No. 501; 149-156 for the protein of sequence SEQ ID




No. 568; 149-156 for the protein of sequence SEQ ID No. 569


 


SEQ ID
QIGENVTR
150-157 for the protein of SEQ No. 562
2b


No. 668


 


SEQ ID
QLLQWMVDAR
202-211 for the protein of SEQ No. 579
SHV


No. 669


 


SEQ ID
QLLQWMVDDGV
202-218 for the protein of SEQ No. 539
SHV


No. 670
AGPLIR


 


SEQ ID
QLLQWMVDDR
202-211 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 671

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 513, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 540,




541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552,




555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566,




567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 580, 581,




582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593,




594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605,




606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913,




1914, 1915, 1916, 1917, 1918, 1919, 1920; 201-210 for the




protein of sequence SEQ ID No. 501; 207-216 for the protein




of sequence SEQ ID No. 530; 201-210 for the protein of




sequence SEQ ID No. 568; 201-210 for the protein of sequence




SEQ ID No. 569; 35-44 for the protein of sequence SEQ ID




No. 1911


 


SEQ ID
QLLQWMVDGR
202-211 for the protein of SEQ No. 553
2b


No. 672


 


SEQ ID
QLLQWMVEDR
202-211 for the protein of SEQ No. 512
SHV


No. 673


 


SEQ ID
QQDLVDYSPVSEK
95-107 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 674

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,




526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537,




538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549,




550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561,




562, 563, 564, 565, 566, 567, 570, 571, 572, 573, 574, 575,




576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,




588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 600,




601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612,




613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919,




1920; 94-106 for the protein of sequence SEQ ID No. 501; 94-106




for the protein of sequence SEQ ID No. 568; 94-106 for




the protein of sequence SEQ ID No. 569


 


SEQ ID
QQHLVDYSPVSEK
95-107 for the protein of SEQ No. 599
2b


No. 675


 


SEQ ID
QSESQLSGR
31-39 for the proteins of SEQ No. 502, 511, 512, 513, 514,
SHV


No. 676

571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582,




583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594,




595, 596, 597, 598, 599, 600, 601, 602, 605, 607, 608, 610,




611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1920


 


SEQ ID
QSESQLSGSVGM
31-51 for the protein of SEQ No. 603
2b


No. 677
IEMDLASGR


 


SEQ ID
SQLQLLQWMVD
199-211 for the proteins of SEQ No. 536, 537, 538
2be


No. 678
DR


 


SEQ ID
SVLPAGWFIADK
219-230 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 679

502, 503, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514,




515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526,




527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 553,




554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565,




566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579,




580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 591, 592,




593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604,




605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913,




1914, 1915, 1916, 1917, 1918, 1919, 1920; 224-235 for the




protein of sequence SEQ ID No. 530; 218-229 for the protein




of sequence SEQ ID No. 568; 218-229 for the protein of




sequence SEQ ID No. 569; 52-63 for the protein of sequence




SEQ ID No. 1911


 


SEQ ID
SVLPAGWFIADR
219-230 for the proteins of SEQ No. 504, 551, 590; 218-229
SHV


No. 680

for the protein of sequence SEQ ID No. 501


 


SEQ ID
SVLSAGWFIADK
219-230 for the protein of SEQ No. 552
2b


No. 681


 


SEQ ID
TGAAER
231-236 for the proteins of SEQ No. 540, 581, 603
SHV


No. 682


 


SEQ ID
TGAAK
231-235 for the protein of SEQ No. 506
2be


No. 683


 


SEQ ID
TGAGER
231-236 for the proteins of SEQ No. 496, 497, 498, 499, 502,
SHV


No. 684

504, 507, 511, 512, 513, 514, 516, 518, 519, 520, 521, 524,




525, 526, 527, 531, 533, 535, 536, 539, 541, 542, 543, 544,




551, 552, 553, 554, 555, 558, 559, 560, 561, 562, 563, 564,




565, 566, 567, 570, 571, 572, 573, 576, 577, 578, 579, 582,




583, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600,




601, 604, 605, 607, 608, 609, 610, 611, 612, 613, 1910, 1912,




1916, 1917, 1918; 230-235 for the protein of sequence SEQ ID




No. 501; 236-241 for the protein of sequence SEQ ID No. 530


 


SEQ ID
TGAGK
231-235 for the proteins of SEQ No. 517, 545, 546, 556, 584,
SHV


No. 685

606


 


SEQ ID
TGASER
64-69 for the proteins of SEQ No. 1911; 231-236 for the
2be


No. 686

protein of sequence SEQ ID No. 503; 231-236 for the protein




of sequence SEQ ID No. 508; 231-236 for the protein of




sequence SEQ ID No. 510; 231-236 for the protein of sequence




SEQ ID No. 522; 231-236 for the protein of sequence SEQ ID




No. 532; 231-236 for the protein of sequence SEQ ID No. 537;




231-236 for the protein of sequence SEQ ID No. 547; 231-236




for the protein of sequence SEQ ID No. 548; 231-236 for the




protein of sequence SEQ ID No. 585


 


SEQ ID
TGASK
231-235 for the proteins of SEQ No. 500, 505, 509, 515, 523,
SHV


No. 687

528, 529, 534, 538, 549, 550, 557, 574, 575, 586, 587, 588,




602, 1913, 1914, 1915, 1919, 1920; 230-234 for the protein of




sequence SEQ ID No. 568; 230-234 for the protein of sequence




SEQ ID No. 569


 


SEQ ID
TGASR
231-235 for the protein of SEQ No. 589
SHV


No. 688


 


SEQ ID
TLTAWCADER
52-61 for the protein of SEQ No. 571
SHV


No. 689


 


SEQ ID
TLTAWHADER
52-61 for the proteins of SEQ No. 516, 517
2be


No. 690


 


SEQ ID
TLTAWR
52-57 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 691

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527,




528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539,




540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551,




552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563,




564, 565, 566, 567, 570, 572, 573, 574, 575, 576, 577, 578,




579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590,




591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602,




603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910,




1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 51-56




for the protein of sequence SEQ ID No. 501; 51-56 for the




protein of sequence SEQ ID No. 568; 51-56 for the protein of




sequence SEQ ID No. 569


 


SEQ ID
TVGGPAGLTAFLR
137-149 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 692

502, 503, 505, 506, 507, 508, 509, 510, 512, 513, 514, 515,




516, 517, 518, 519, 521, 522, 523, 524, 527, 528, 529, 530,




531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542,




543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554,




555, 556, 557, 558, 559, 560, 561, 562, 564, 565, 566, 570,




571, 573, 574, 575, 577, 578, 579, 580, 581, 582, 583, 584,




585, 586, 587, 588, 589, 590, 591, 592, 596, 597, 598, 599,




600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611,




612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1918, 1919,




1920; 136-148 for the protein of sequence SEQ ID No. 568;




136-148 for the protein of sequence SEQ ID No. 569


 


SEQ ID
TVVIYLR
254-260 for the protein of SEQ No. 546
SHV


No. 693


 


SEQ ID
VAGPLIR
212-218 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 694

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,




526, 527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538,




539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550,




551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562,




563, 564, 565, 566, 567, 570, 571, 572, 573, 574, 575, 576,




577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588,




589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600,




601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612,




613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919,




1920; 211-217 for the protein of sequence SEQ ID No. 501;




217-223 for the protein of sequence SEQ ID No. 530; 211-217




for the protein of sequence SEQ ID No. 568; 211-217 for the




protein of sequence SEQ ID No. 569; 45-51 for the protein of




sequence SEQ ID No. 1911


 


SEQ ID
VALCGAVLAR
70-79 for the protein of SEQ No. 573
2b


No. 695


 


SEQ ID
VDAGDEQLER
80-89 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 696

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,




526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537,




538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549,




550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561,




562, 563, 564, 565, 566, 567, 570, 571, 572, 573, 574, 576,




577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588,




589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 601,




602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613,




1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920;




79-88 for the protein of sequence SEQ ID No. 501; 79-88 for




the protein of sequence SEQ ID No. 568; 79-88 for the protein




of sequence SEQ ID No. 569


 


SEQ ID
VDAGDK
80-85 for the proteins of SEQ No. 575, 600
SHV


No. 697


 


SEQ ID
VGMIEMDLASGR
40-51 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 698

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,




526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537,




538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549,




550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561,




562, 563, 564, 565, 566, 567, 571, 572, 573, 574, 575, 576,




577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588,




589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600,




601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612,




613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919,




1920; 39-50 for the protein of sequence SEQ ID No. 501


 


SEQ ID
VGMIEMDLASR
40-50 for the proteins of SEQ No. 568, 569
SHV


No. 699


 


SEQ ID
VGMIEMDLASSR
40-51 for the protein of SEQ No. 570
SHV


No. 700


 


SEQ ID
VLLCGAVLAR
70-79 for the protein of SEQ No. 574
SHV


No. 701


 


SEQ ID
VVLCGAMLAR
70-79 for the protein of SEQ No. 575
2be


No. 702


 


SEQ ID
VVLCGAVLAR
70-79 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 703

502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,




526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537,




538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549,




550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561,




562, 563, 564, 565, 566, 567, 570, 571, 572, 576, 577, 578,




579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590,




591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 602, 603,




604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912,




1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 69-78 for the




protein of sequence SEQ ID No. 501; 69-78 for the protein of




sequence SEQ ID No. 568; 69-78 for the protein of sequence




SEQ ID No. 569


 


SEQ ID
VVLCGTVLAR
70-79 for the protein of SEQ No. 601
2b


No. 704


 


SEQ ID
WETDR
161-165 for the protein of SEQ No. 530
2be


No. 705


 


SEQ ID
WETELNEAFPGD
161-174 for the proteins of SEQ No. 522, 531, 532
SHV


No. 706
AR


 


SEQ ID
WETELNEALPAD
161-174 for the protein of SEQ No. 526
2b


No. 707
AR


 


SEQ ID
WETELNEALPGD
161-174 for the proteins of SEQ No. 496, 497, 498, 499, 500,
SHV


No. 708
AR
502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,




514, 515, 516, 517, 518, 519, 520, 521, 523, 524, 525, 527,




528, 529, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542,




543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554,




555, 556, 557, 558, 559, 562, 563, 564, 565, 566, 567, 570,




571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582,




583, 584, 585, 586, 587, 588, 589, 590, 591, 593, 594, 595,




596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607,




608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915,




1916, 1917, 1918, 1919, 1920; 160-173 for the protein of




sequence SEQ ID No. 501; 166-179 for the protein of sequence




SEQ ID No. 530; 160-173 for the protein of sequence SEQ ID




No. 568; 160-173 for the protein of sequence SEQ ID No. 569


 


SEQ ID
WETELNEALSGD
161-174 for the protein of SEQ No. 560
2b


No. 709
AR


 


SEQ ID
WETELNEVLPGD
161-174 for the protein of SEQ No. 592
SHV


No. 710
AR


 


SEQ ID
WETER
161-165 for the protein of SEQ No. 561
SHV


No. 711


 


SEQ ID
EIGDNVTR
150-157 for the proteins of SEQ No. 1915
SHV


No. 2093


 


SEQ ID
GIVALLGPHNK
240-250 for the proteins of SEQ No. 1917
SHV


No. 2094


 


SEQ ID
HLADGMTVGELR
108-119 for the proteins of SEQ No. 1914
2be


No. 2095


 


SEQ ID
IHYSQQDLVDYS
91-107 for the proteins of SEQ No. 1918
SHV


No. 2096
PVSEK









In the clinical interest column, the entries 2b, 2br, 2be and 2ber correspond to the functional subgroups of the SHV beta-lactamases which the corresponding peptide makes it possible to detect. Thus, the detection of a 2be peptide will indicate the presence of a beta-lactamase with an extended spectrum (ESBL) capable of hydrolysing penicillins, first-generation cephalosporins such as cephaloridine and cefalotin, and at least one antibiotic from the oxyimino-beta-lactam class such as cefotaxime, ceftazidime or monobactams such as aztreonam.
The entry SHV indicates a common peptide between at least two of the subgroups 2b, 2br and 2be or 2ber. The corresponding peptide indicates the presence of an SHV beta-lactamase and the presence of a mechanism of resistance at least to penicillins and to first-generation cephalosporins.
The detection of a mechanism of resistance to ESBL (extended-spectrum beta-lactamase) cephalosporins, induced by the SHV protein, is characterised by the detection of at least one resistance-marking 2be peptide, chosen from the sequences SEQ ID No. 616, SEQ ID No. 617, SEQ ID No. 627, SEQ ID No. 629, SEQ ID No. 634, SEQ ID No. 647, SEQ ID No. 648, SEQ ID No. 653, SEQ ID No. 654, SEQ ID No. 656, SEQ ID No. 660, SEQ ID No. 661, SEQ ID No. 662, SEQ ID No. 663, SEQ ID No. 664, SEQ ID No. 665, SEQ ID No. 670, SEQ ID No. 673, SEQ ID No. 674, SEQ ID No. 675, SEQ ID No. 678, SEQ ID No. 682, SEQ ID No. 684, SEQ ID No. 685, SEQ ID No. 686, SEQ ID No. 687, SEQ ID No. 688, SEQ ID No. 697, SEQ ID No. 702, SEQ ID No. 703, SEQ ID No. 704, SEQ ID No. 707, SEQ ID No. 708, SEQ ID No. 709, SEQ ID No. 711, SEQ ID No. 2095.
The detection of a mechanism of resistance to cephalosporins induced by the expression of the FOX protein is characterised by the detection of at least one peptide belonging to the FOX protein and to its different sequence variants SEQ ID No. 712 to SEQ ID No. 718 and SEQ ID No. 1920 to SEQ ID No. 1922.







SEQ ID No. 712:


MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSND


 


KMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSA


 


DLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTE


 


QTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 713:


MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSND


 


KMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSA


 


DLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTE


 


QTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 14:


MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSND


 


KMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSA


 


DLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTE


 


QALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 715:


MQQRRALALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKEYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSND


 


KMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEKLMSQTLL


 


PKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSA


 


DLLKFVEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPVTE


 


QALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 716:


MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSND


 


KMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSA


 


DLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTE


 


QVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 717:


MQQRRALALLMLGSLLLAPCTYASGEAPLTATVDGIIQPMLKAYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSND


 


KMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSA


 


DLLKFVEANMGYQGDAALKSAIALTHTGFHSVGEMTQGLGWESYDYPVTE


 


QVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 718:


MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSND


 


KMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAIANYAYGYSKEDKPVRATPGVLAAEAYGIKTGSA


 


DLLKFTEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPLTE


 


QALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 1920:


MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSND


 


KMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSA


 


DLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTE


 


QVLLAGNSPAVSLQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 1921:


MQQRRAFALLTLGSLLLAPCTYASGEAPLTVTVDGIIQPMLKAYRIPGMA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPEEVDSND


 


KMRTYYRSWSPVYPAGTHRQYANTSIGLFGYLAANSLGQSFEQLMSQTLL


 


PKLGLHHTYIQVPESAMANYAYGYSKEEKPIRVTPGMLAAEAYGIKTGSA


 


DLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYDYPVTE


 


QVLLADNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE


 


SEQ ID No. 1922:


MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIA


 


VAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAV


 


KGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSND


 


KMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLL


 


PKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSA


 


DLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTE


 


QVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVP


 


ARGIAIVMLANRNYPIEARVKAAHAILSQLAE






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 719 to SEQ ID No. 733 and SEQ ID No. 2097 to SEQ ID No. 2113 as defined hereafter:












Peptide SEQ




ID No.
Amino acid sequence
Position of the peptide in the FOX protein







SEQ ID No.
AHYFNYGVANR
59-69 for the proteins of SEQ No. 712, 713,


719

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
AMGEQR
326-331 for the proteins of SEQ No. 712, 713,


720

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
ESGQR
70-74 for the proteins of SEQ No. 712, 713,


721

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
FAVPK
321-325 for the proteins of SEQ No. 712, 713,


722

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
GGFELDDK
102-109 for the proteins of SEQ No. 712, 713,


723

714, 715, 717, 718, 1921


 


SEQ ID No.
GIAIVMLANR
353-362 for the proteins of SEQ No. 712, 713,


724

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
IPGMAVAVLK
46-55 for the proteins of SEQ No. 712, 713,


725

714, 715, 717, 718, 1921


 


SEQ ID No.
NYPIEAR
363-369 for the proteins of SEQ No. 712, 713,


726

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
SWSPVYPAGTHR
158-169 for the proteins of SEQ No. 712, 713,


727

715, 716, 717, 1920, 1921, 1922


 


SEQ ID No.
TGSADLLK
247-254 for the proteins of SEQ No. 712, 713,


728

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
TGSTGGFGAYVAFVPAR
336-352 for the proteins of SEQ No. 712, 713,


729

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
TLTATLGAYAAVK
89-101 for the proteins of SEQ No. 712, 713,


730

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
VSEQTLFEIGSVSK
75-88 for the proteins of SEQ No. 712, 713,


731

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
VSQHAPWLK
110-118 for the proteins of SEQ No. 712, 713,


732

714, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
VTPGVLAAEAYGIK
233-246 for the proteins of SEQ No. 712, 713,


733

714, 715, 716, 1920, 1922


 


SEQ ID No.
AFALLTLGSLLLAPCTYAR
6-24 for the proteins of SEQ No. 714, 718


2097


 


SEQ ID No.
ATPGVLAAEAYGIK
233-246 for the proteins of SEQ No. 717, 718


2098


 


SEQ ID No.
EDKPVR
227-232 for the proteins of SEQ No. 712, 713,


2099

714, 718


 


SEQ ID No.
EEKPIR
227-232 for the proteins of SEQ No. 1921


2100


 


SEQ ID No.
FAEANMGYQGDAAVK
255-269 for the proteins of SEQ No. 712, 713,


2101

1921


 


SEQ ID No.
FAEANMGYQGDALVK
255-269 for the proteins of SEQ No. 716,


2102

1920, 1922


 


SEQ ID No.
FTEANMGYQGDAALK
255-269 for the proteins of SEQ No. 714, 718


2103


 


SEQ ID No.
FVEANMGYQGDAALK
255-269 for the proteins of SEQ No. 715, 717


2104


 


SEQ ID No.
GEAPLTAAVDGIIQPMLK
25-42 for the proteins of SEQ No. 712, 713,


2105

714, 715, 718


 


SEQ ID No.
GGFVLDDK
102-109 for the proteins of SEQ No. 716,


2106

1920, 1922


 


SEQ ID No.
HWSPVYPAGTHR
158-169 for the proteins of SEQ No. 714, 718


2107


 


SEQ ID No.
IPGIAVAVLK
46-55 for the proteins of SEQ No. 716, 1920,


2108

1922


 


SEQ ID No.
LMSQTLLPK
194-202 for the proteins of SEQ No. 712, 713,


2109

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
MQTYYR
152-157 for the proteins of SEQ No. 715, 716,


2110

717, 1920, 1922


 


SEQ ID No.
VDSNDK
146-151 for the proteins of SEQ No. 712, 713,


2111

714, 715, 716, 717, 718, 1920, 1921, 1922


 


SEQ ID No.
VSHHAPWLK
110-118 for the protein of SEQ No. 715


2112


 


SEQ ID No.
VTPGMLAAEAYGIK
233-246 for the proteins of SEQ No. 1921


2113









The detection of a mechanism of resistance to cephalosporins induced by the expression of the ACC protein is characterised by the detection of at least one peptide belonging to the ACC protein and to its different sequence variants SEQ ID No. 736 to SEQ ID No. 739.







SEQ ID No. 736:


MRKKMQNTLKLLSVITCLAATAQGAMAANIDESKIKDTVDGLIQPLMQKN


 


NIPGMSVAVTIRGRNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAAIL


 


ASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPED


 


IKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAI


 


EQTILPLLGMNQTYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGI


 


KTTSSDLLRYVQANMGQLKLDGNAKIQHALTATHTGYFKSGEITQDLMWE


 


QLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGA


 


YIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEVNK


 


SEQ ID No. 737:


MRKKMQNTLKMLSVITCLALTAQGAMASEMDQAKIKDTVDSLIQPLMQKN


 


NIPGMSVAVTLNGKNYIYNYGLASKQPQQPVTDNTLFEVGSLSKTFAATL


 


ASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTTGLALFMPEE


 


VKNTDQLMAYLKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAI


 


EKTLLPKLGMTHTYLNVPADQAENYAWGYNKKNEPIHVNMEVLGNEAYGI


 


RTNASDLIRYVQANMGQLKLDGNSTLQKALTDTHIGYFKSGKITQDLMWE


 


QLPYPVSLPDLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGA


 


YIAFVPAKKMGIVMLANKNYSIDQRVT


 


SEQ ID No. 738:


MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPG


 


MSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYA


 


QVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNT


 


TQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTL


 


LPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTS


 


SDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPY


 


PVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAF


 


VPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK


 


SEQ ID No. 739:


MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPG


 


MSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYA


 


QVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNT


 


TQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTL


 


LPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTS


 


SDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPY


 


PVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAF


 


VPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 740 to SEQ ID No. 787 as defined hereafter:












Peptide




SEQ ID

Position of the peptide in the ACC


No.
Amino acid sequence
protein(s)







SEQ ID
ALTDTHIGYFK
279-289 for the protein of SEQ No. 737


No. 740


 


SEQ ID
AWKPADAAGTHR
159-170 for the proteins of SEQ No. 738,


No. 741

739; 163-174 for the protein of sequence




SEQ ID No. 736


 


SEQ ID
AWKPADPAGTHR
163-174 for the protein of SEQ No. 737


No. 742


 


SEQ ID
DEPVHGNMEILGNEAYGIK
229-247 for the protein of SEQ No. 738


No. 743


 


SEQ ID
DEPVHVNMEILGNEAYGIK
229-247 for the protein of SEQ No. 739; 233-251


No. 744

for the protein of sequence SEQ ID No.




736


 


SEQ ID
DTVDDLIQPLMQK
33-45 for the proteins of SEQ No. 738, 739


No. 745


 


SEQ ID
DTVDGLIQPLMQK
37-49 for the protein of SEQ No. 736


No. 746


 


SEQ ID
DTVDSLIQPLMQK
37-49 for the protein of SEQ No. 737


No. 747


 


SEQ ID
IQHALTATHTGYFK
276-289 for the protein of SEQ No. 736


No. 748


 


SEQ ID
LDANAK
266-271 for the proteins of SEQ No. 738, 739


No. 749


 


SEQ ID
LDGNAK
270-275 for the protein of SEQ No. 736


No. 750


 


SEQ ID
LDGNSTLQK
270-278 for the protein of SEQ No. 737


No. 751


 


SEQ ID
LGMTHTYLNVPADQAENYAWGYNK
208-231 for the protein of SEQ No. 737


No. 752


 


SEQ ID
LLSVITCLAATAQGAMAANIDESK
11-34 for the protein of SEQ No. 736


No. 753


 


SEQ ID
LLSVITCLAATVQGALAANIDESK
7-30 for the proteins of SEQ No. 738, 739


No. 754


 


SEQ ID
LSLDK
110-114 for the protein of SEQ No. 737


No. 755


 


SEQ ID
LSLDQSVSHYVPELR
106-120 for the proteins of SEQ No. 738, 739


No. 756


 


SEQ ID
LSLEQSVSHYVPELR
110-124 for the protein of SEQ No. 736


No. 757


 


SEQ ID
MGIVMLANK
356-364 for the proteins of SEQ No. 738,


No. 758

739; 360-368 for the proteins of sequence




SEQ ID No. 736, 737


 


SEQ ID
MLSVITCLALTAQGAMASEMDQAK
11-34 for the protein of SEQ No. 737


No. 759


 


SEQ ID
MQNTLK
1-6 for the proteins of SEQ No. 738, 739; 5-10


No. 760

10 for the proteins of sequence SEQ ID No.




736, 737


 


SEQ ID
MQQALTATHTGYFK
272-285 for the proteins of SEQ No. 738, 739


No. 761


 


SEQ ID
NEPIHVNMEVLGNEAYGIR
233-251 for the protein of SEQ No. 737


No. 762


 


SEQ ID
NNIPGMSVAVTIR
50-62 for the protein of SEQ No. 736


No. 763


 


SEQ ID
NNIPGMSVAVTLNGK
50-64 for the protein of SEQ No. 737


No. 764


 


SEQ ID
NNIPGMSVAVTVNGK
46-60 for the proteins of SEQ No. 738, 739


No. 765


 


SEQ ID
NTDQLMAYLK
153-162 for the protein of SEQ No. 737


No. 766


 


SEQ ID
NTTQLMAYLK
149-158 for the proteins of SEQ No. 738, 739


No. 767


 


SEQ ID
NTTQLMTYLK
153-162 for the protein of SEQ No. 736


No. 768


 


SEQ ID
NYIYNYGLAAK
61-71 for the proteins of SEQ No. 738, 739;


No. 769

65-75 for the protein of sequence SEQ ID




No. 736


 


SEQ ID
NYIYNYGLASK
65-75 for the protein of SEQ No. 737


No. 770


 


SEQ ID
NYSIDQR
365-371 for the proteins of SEQ No. 738,


No. 771

739; 369-375 for the protein of sequence




SEQ ID No. 736, 737


 


SEQ ID
QPQQPVTDNTLFEVGSLSK
76-94 for the protein of SEQ No. 737


No. 772


 


SEQ ID
QPQQPVTENTLFEVGSLSK
72-90 for the proteins of SEQ No. 738, 739;


No. 773

76-94 for the protein of sequence SEQ ID




No. 736


 


SEQ ID
SISHYVPELR
115-124 for the protein of SEQ No. 737


No. 774


 


SEQ ID
SLGVSYEDAIEK
187-198 for the proteins of SEQ No. 738, 739


No. 775


 


SEQ ID
SVATPIVPPLPPQENVWINK
318-337 for the proteins of SEQ No. 738,


No. 776

739; 322-341 for the protein of sequence




SEQ ID No. 736, 737


 


SEQ ID
TFAAILASYAQASGK
95-109 for the protein of SEQ No. 736


No. 777


 


SEQ ID
TFAATLASYAQVSGK
91-105 for the proteins of SEQ No. 738, 739;


No. 778

95-109 for the protein of sequence SEQ ID




No. 737


 


SEQ ID
TGSTNGFGAYIAFVPAK
338-354 for the proteins of SEQ No. 738,


No. 779

739; 342-358 for the protein of sequence




SEQ ID No. 736, 737


 


SEQ ID
TLLPK
203-207 for the protein of SEQ No. 737


No. 780


 


SEQ ID
TLLPQLGMHHSYLK
199-212 for the proteins of SEQ No. 738, 739


No. 781


 


SEQ ID
TNASDLIR
252-259 for the protein of SEQ No. 737


No. 782


 


SEQ ID
TTSSDLLR
248-255 for the proteins of SEQ No. 738,


No. 783

739; 252-259 for the protein of sequence




SEQ ID No. 736


 


SEQ ID
VPADQMENYAWGYNK
213-227 for the proteins of SEQ No. 738,


No. 784

739; 217-231 for the protein of sequence




SEQ ID No. 736


 


SEQ ID
VTVAYK
372-377 for the proteins of SEQ No. 738,


No. 785

739; 376-381 for the protein of sequence




SEQ ID No. 736


 


SEQ ID
VYSNIGTGLLGMIAAK
171-186 for the proteins of SEQ No. 738,


No. 786

739; 175-190 for the protein of sequence




SEQ ID No. 736


 


SEQ ID
YVQANMGQLK
256-265 for the proteins of SEQ No. 738,


No. 787

739; 260-269 for the protein of sequence




SEQ ID No. 736, 737









The detection of a mechanism of resistance to cephalosporins induced by the expression of the ACT protein is characterised by the detection of at least one peptide belonging to the ACT protein and to its different sequence variants SEQ ID No. 788 to SEQ ID No. 794.







SEQ ID No. 788:


MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMA


 


VAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIA


 


RGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNA


 


SLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVF


 


KPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQD


 


MASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVD


 


AKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFI


 


PEKQLGIVMLANKSYPNPARVEAAYRILSAL


 


SEQ ID No. 789:


MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMA


 


VAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIA


 


RGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNA


 


SLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVF


 


KPLKLDHTWINVPKAEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNVQD


 


MASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVD


 


AKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFI


 


PEKQLGIVMLANKSYPNPARVEAAYRILSAL


 


SEQ ID No. 790:


MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNAS


 


LLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFK


 


PLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDM


 


ASWVMVNMKPDSLQDNSLRQGIALAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYRILSAL


 


SEQ ID No. 791:


MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFK


 


PLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDM


 


ANWVMVNMKPDSLQDSSLKEGITLAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYRILDALQ


 


SEQ ID No. 792:


MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAV


 


AVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLK


 


PLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDM


 


ANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEA


 


NTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQIGIVMLANTSYPNPARVEAAYHILEALQ


 


SEQ ID No. 793:


MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAV


 


AVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAA


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLK


 


PLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDM


 


ANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEA


 


NTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQIGIVMLANKSYPNPARVEAAYPILDALQ


 


SEQ ID No. 794:


MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMA


 


VAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIA


 


RGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNA


 


SLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVF


 


KPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQD


 


MASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVD


 


AKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFI


 


PEKQLGIVMLANKSYPNPARVEAAYRILSAL






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 795 to SEQ ID No. 841 as defined hereafter:












Peptide




SEQ ID

Position of the peptide in the ACT


No.
Amino acid sequence
protein(s)







SEQ ID
ADIAANK
66-72 for the protein of SEQ No. 792


No. 795


 


SEQ ID
ADIAASK
66-72 for the protein of SEQ No. 793


No. 796


 


SEQ ID
ADVAANK
67-73 for the proteins of SEQ No. 788,


No. 797

789, 794; 66-72 for the protein of




sequence SEQ ID No. 790, 791


 


SEQ ID
AEEAHYAWGYR
215-225 for the proteins of SEQ No. 788,


No. 798

789, 794; 214-224 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
AIHVSPGMLDAEAYGVK
229-245 for the protein of SEQ No. 789


No. 799


 


SEQ ID
AQSIPGMAVAVIYQGK
42-57 for the protein of SEQ No. 793


No. 800


 


SEQ ID
AQSVPGMAVAVIYQGK
42-57 for the protein of SEQ No. 792


No. 801


 


SEQ ID
AVHVSPGMLDAEAYGVK
229-245 for the proteins of SEQ No. 788,


No. 802

794; 228-244 for the proteins of sequence




SEQ ID No. 790, 791


 


SEQ ID
DMANWVMVNMK
249-259 for the protein of SEQ No. 791


No. 803


 


SEQ ID
DMANWVMVNMKPDSLQDSSLK
249-269 for the protein of SEQ No. 791


No. 804


 


SEQ ID
DNASLLR
148-154 for the proteins of SEQ No. 788,


No. 805

789, 794; 147-153 for the proteins of




sequence SEQ ID No. 790, 791, 792


 


SEQ ID
EGITLAQSR
270-278 for the protein of SEQ No. 791


No. 806


 


SEQ ID
EVNPPAPPVNASWVHK
321-336 for the proteins of SEQ No. 788,


No. 807

789, 794; 320-335 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
FYQNWQPQWK
155-164 for the proteins of SEQ No. 788,


No. 808

789, 794; 154-163 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
FYQNWQPQWKPGTTR
155-169 for the proteins of SEQ No. 788,


No. 809

789, 794; 154-168 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
GEISLDDPVTR
101-111 for the proteins of SEQ No. 792,


No. 810

793


 


SEQ ID
GEISLGDPVTK
102-112 for the proteins of SEQ No. 788,


No. 811

789, 794; 101-111 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
GLTLAQSR
272-279 for the proteins of SEQ No. 788,


No. 812

789, 794


 


SEQ ID
LDHTWINVPK
205-214 for the proteins of SEQ No. 788,


No. 813

789, 794; 204-213 the proteins of




sequence SEQ ID No. 791, 792, 793


 


SEQ ID
LYANASIGLFGALAVK
170-185 for the proteins of SEQ No. 788,


No. 814

789, 794; 169-184 for the proteins of




sequence SEQ ID No. 791, 792, 793


 


SEQ ID
LYANTSIGLFGALAVK
169-184 for the protein of SEQ No. 790


No. 815


 


SEQ ID
MLDLATYTAGGLPLQVPDEVK
127-147 for the protein of SEQ No. 788


No. 816


 


SEQ ID
QGIALAQSR
270-278 for the proteins of SEQ No. 790,


No. 817

792


 


SEQ ID
QGISLAQSR
270-278 for the protein of SEQ No. 793


No. 818


 


SEQ ID
QIGIVMLANK
353-362 for the protein of SEQ No. 793


No. 819


 


SEQ ID
QIGIVMLANTSYPNPAR
353-369 for the protein of SEQ No. 792


No. 820


 


SEQ ID
QLAEVVANTVTPLMK
27-41 for the proteins of SEQ No. 792,


No. 821

793


 


SEQ ID
QLAEVVER
28-35 for the proteins of SEQ No. 788,


No. 822

789, 794; 27-34 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
QLGIVMLANK
354-363 for the proteins of SEQ No. 788,


No. 823

789, 794; 353-362 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
SYPNPAR
364-370 for the proteins of SEQ No. 788,


No. 824

789, 794; 363-369 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
TFTGVLGGDAIAR
89-101 for the proteins of SEQ No. 788,


No. 825

789, 794; 88-100 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
TGSTGGFGSYVAFIPEK
337-353 for the proteins of SEQ No. 788,


No. 826

789, 794; 336-352 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
TNVQDMASWVMVNMK
246-260 for the proteins of SEQ No. 788,


No. 827

789, 794; 245-259 for the protein of




sequence SEQ ID No. 790


 


SEQ ID
TVTPLMK
36-42 for the proteins of SEQ No. 788,


No. 828

789, 794; 35-41 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
TVVEGSDNK
303-311 for the proteins of SEQ No. 788,


No. 829

789, 794; 302-310 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
VALAPLPAR
312-320 for the proteins of SEQ No. 788,


No. 830

789, 794; 311-319 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
VALAPLPVAEVNPPAPPVK
311-329 for the proteins of SEQ No. 792,


No. 831

793


 


SEQ ID
VEAAYR
371-376 for the proteins of SEQ No. 788,


No. 832

789, 794; 370-375 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
VFKPLK
199-204 for the proteins of SEQ No. 788,


No. 833

789, 794; 198-203 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
VGAMYQGLGWEMLNWPVDAK
283-302 for the proteins of SEQ No. 788,


No. 834

789, 794; 282-301 for the proteins of




sequence SEQ ID No. 790, 791


 


SEQ ID
VLKPLK
198-203 for the proteins of SEQ No. 792,


No. 835

793


 


SEQ ID
VSPGMLDAQAYGMK
231-244 for the protein of SEQ No. 793


No. 836


 


SEQ ID
VSPGMLDAQAYGVK
231-244 for the protein of SEQ No. 792


No. 837


 


SEQ ID
YWPQLTGK
112-119 for the proteins of SEQ No. 792,


No. 838

793


 


SEQ ID
ASWVHK
331-336 for the proteins of SEQ No. 788,


No. 839

789, 794; 330-335 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
QWQGIR
121-126 for the proteins of SEQ No. 788,


No. 840

789, 794; 120-125 for the proteins of




sequence SEQ ID No. 790, 791, 792, 793


 


SEQ ID
YWPELTGK
113-120 for the proteins of SEQ No. 788,


No. 841

789, 794; 112-119 for the proteins of




sequence SEQ ID No. 790, 791









The detection of a mechanism of resistance to cephalosporins induced by the expression of the CARB protein is characterised by the detection of at least one peptide belonging to the CARB protein and to its different sequence variants SEQ ID No. 842 to SEQ ID No. 852.







SEQ ID No. 842:


MLLYKMCDNQNYGVTYMKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEV


 


SLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKV


 


NPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIIL


 


SAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIAST


 


LNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGG


 


FGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYT


 


SQSR


 


SEQ ID No. 843:


MLLYKMCDNQNYGVTYMKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEV


 


SLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKV


 


NPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIIL


 


SAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIAST


 


LNKLLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGG


 


FGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYT


 


SQSR


 


SEQ ID No. 844:


MKLLLVFSLLIPSMVFANSSKFQQVEQDAKVIEASLSAHIGISVLDTQTG


 


EYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGEINPKSTIEIKKADLVTY


 


SPVIEKQVGQAITLDDACFATMTTSDNAAANIILNALGGPESVTDFLRQI


 


GDKETRLDRIEPELNEGKLGDLRDTTTPNAIVNTLNELLFGSTLSQDGQK


 


KLEYWMVNNQVTGNLLRSVLPEGWNIADRSGAGGFGARSITAVVWSEAQS


 


PIIVSIYLAQTEASIADRNDAIVKIGRSIFEVYSSQSR


 


SEQ ID No. 845:


MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNG


 


EYWDYNGNQRFPLTSTEKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTY


 


SPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQI


 


GDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNQLLFGSTLSEASQK


 


KLESWMVNNQVTGNLLRSVLPVKWSIADRSGAGGFGARSITAIVWSEEKK


 


TIIVSIYLAQTEASMAERNDAIVKIGRSIFEVYTSQSR


 


SEQ ID No. 846:


MNVRKHKASFFSVVITFLCLTLSLNANATDSVLEAVTNAETELGARIGLA


 


VHDLETGKRWEHKSNERFPLSSTFKTLACANVLQRVDLGKERIDRVVRFS


 


ESNLVTYSPVTEKHVGKKGMSLAELCQATLSTSDNSAANFILQAIGGPKA


 


LTKFLRSIGDDTTRLDRWETELNEAVPGDKRDTTTPIAMVTTLEKLLIDE


 


TLSIKSRQQLESWLKGNEVGDALFRKGVPSDWIVADRTGAGGYGSRAITA


 


VMWPPNRKPIVAALYITETDASFEERNAVIAKIGEQIAKTVLMENSRN


 


SEQ ID No. 847:


MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNG


 


EYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNSNSTVEIKKADLVTY


 


SPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQI


 


GDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQK


 


KLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQA


 


PIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYTSQSR


 


SEQ ID No. 848:


MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNG


 


EYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTY


 


SPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQI


 


GDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQK


 


KLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQA


 


PIIVSIYLAQTQASMEERNDAIVKIGHSIFDVYTSQSR


 


SEQ ID No. 849:


MKSLLVFALLMPSVVFASSSKFQSVEQEIKGIESSLSARIGVAILDTQNG


 


ESWDYNGDQRFPLTSTFKTIACAKLLYDAEHGKVNLNSTVEIKKADLVTY


 


SPVLEKQVGKPITLSDACLATMTTSDNTAANIVINAVGDPKSITDFLRQI


 


GDKETRLDRVEPELNEGKLGDLRDTTTPNAITSTLNQLLFGSTLSEASQK


 


KLESWMVNNQVTGNLLRSVLPVKWSIADRSGAGGFGARSITAIVWSEEKK


 


PIIVSIYLAQTEASMAERNDAIVKIGRSIFEVYTSQSR


 


SEQ ID No. 850:


MDVRKHKASFFSWITFLCLTLSLNANATDSVLEAVTNAETELGARIGLAV


 


HDLETGKRWEHKSNERFPLSSTFKTLACANVLQRVDLGKERIDRVVRFSE


 


SNLVTYSPVTEKHVGKKGMSLAELCQATLSTSDNSAANFILQAIGGPKAL


 


TKFLRSIGDDTTRLDRWETELNEAVPGDKRDTTTPIAMVTTLEKLLIDET


 


LSIKSRQQLESWLKGNEVGDALFRKGVPSDWIVADRTGAGGYGSRAITAV


 


MWPPNRKPIVAALYITETDASFEERNAVIAKIGEQIAKTILMENSRN


 


SEQ ID No. 851:


MKSLLVFALLMPSVVFASSSKFQSVEQEIKGIESSLSARIGVAILDTQNG


 


ESWDYNGDQRFPLTSTFKTIACAKLLYDAEHGKVNLNSTVEVKKADLVTY


 


SPVLEKQVGKPITLSDACFATMTTSDNTAANIVINAVGDPKSITDFLRQI


 


GDKETRLDRVEPELNEGKLGDLRDTTTPNAITSTLNQLLFGSTLSEASQK


 


KLESWMVNNQVTGNLLRSVLPVTWSIADRSGAGGFGARSITAIVWSEEKK


 


PIIVSIYLAQTEASMAERNDAIVKIGRSIFEVYTSQSR


 


SEQ ID No. 852:


MKFLLVFSLLIPSVVFASSSKFRQVEQDVKAIEVSLSARIGVSVLDTQNG


 


EYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTY


 


SPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGSKGVTDFLRQI


 


GDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNKK


 


KLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQA


 


PIIVSIYLAQTQASMAERNDAIVKIGRSIFDVYTSQSR






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 853 to SEQ ID No. 921 as defined hereafter:












Peptide




SEQ ID

Position of the peptide in the CARB


No.
Amino acid sequence
protein(s)







SEQ ID
ADLVTYSPVIEK
95-106 for the proteins of SEQ No. 844,


No. 853

845, 847, 848, 852; 111-122 for the protein




of sequence SEQ ID No. 842; 111-122 for




the protein of sequence SEQ ID No. 843


 


SEQ ID
ADLVTYSPVLEK
95-106 for the proteins of SEQ No. 849,


No. 854

851


 


SEQ ID
AIASTLNK
180-187 for the proteins of SEQ No. 847,


No. 855

848, 852; 196-203 for the protein of




sequence SEQ ID No. 842; 196-203 for the




protein of sequence SEQ ID No. 843


 


SEQ ID
AIASTLNQLLFGSTLSEASQK
180-200 for the protein of SEQ No. 845


No. 856


 


SEQ ID
AIEVSLSAR
31-39 for the proteins of SEQ No. 845, 847,


No. 857

848, 852; 47-55 for the protein of sequence




SEQ ID No. 842; 47-55 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
AITAVMWPPNR
247-257 for the proteins of SEQ No. 846,


No. 858

850


 


SEQ ID
DTTTPIAMVTTLEK
182-195 for the proteins of SEQ No. 846,


No. 859

850


 


SEQ ID
DTTTPK
174-179 for the proteins of SEQ No. 845,


No. 860

847, 848, 852; 190-195 for the protein of




sequence SEQ ID No. 842; 190-195 for the




protein of sequence SEQ ID No. 843


 


SEQ ID
FLFGSALSEMNK
188-199 for the protein of SEQ No. 852


No. 861


 


SEQ ID
FLFGSALSEMNQK
188-200 for the proteins of SEQ No. 847,


No. 862

848; 204-216 for the protein of sequence




SEQ ID No. 842


 


SEQ ID
FLLAFSLLIPSVVFASSSK
3-21 for the proteins of SEQ No. 845, 847,


No. 863

848; 19-37 for the protein of sequence SEQ




ID No. 842; 19-37 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
FLLVFSLLIPSVVFASSSK
3-21 for the protein of SEQ No. 852


No. 864


 


SEQ ID
FPLSSTFK
68-75 for the proteins of SEQ No. 846, 850


No. 865


 


SEQ ID
FPLTSTFK
61-68 for the proteins of SEQ No. 844, 845,


No. 866

847, 848, 849, 851, 852; 77-84 for the




protein of sequence SEQ ID No. 842; 77-84




for the protein of sequence SEQ ID No. 843


 


SEQ ID
FQQVEQDAK
22-30 for the protein of SEQ No. 844


No. 867


 


SEQ ID
FQQVEQDAK
22-30 for the proteins of SEQ No. 845, 847,


No. 868

848; 38-46 for the protein of sequence SEQ




ID No. 842; 38-46 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
FQSVEQEIK
22-30 for the proteins of SEQ No. 849, 851


No. 869


 


SEQ ID
FSESNLVTYSPVTEK
99-113 for the proteins of SEQ No. 846,


No. 870

850


 


SEQ ID
GIESSLSAR
31-39 for the proteins of SEQ No. 849, 851


No. 871


 


SEQ ID
GNEVGDALFR
216-225 for the proteins of SEQ No. 846,


No. 872

850


 


SEQ ID
GVPSDWIVADR
227-237 for the proteins of SEQ No. 846,


No. 873

850


 


SEQ ID
GVTDFLR
142-148 for the proteins of SEQ No. 845,


No. 874

847, 848, 852; 158-164 for the protein of




sequence SEQ ID No. 842; 158-164 for the




protein of sequence SEQ ID No. 843


 


SEQ ID
IEPDLNEGK
160-168 for the proteins of SEQ No. 845,


No. 875

847, 848, 852; 176-184 for the protein of




sequence SEQ ID No. 842; 176-184 for the




protein of sequence SEQ ID No. 843


 


SEQ ID
IEPELNEGK
160-168 for the protein of SEQ No. 844


No. 876


 


SEQ ID
IGEQIAK
283-289 for the proteins of SEQ No. 846,


No. 877

850


 


SEQ ID
IGLAVHDLETGK
47-58 for the proteins of SEQ No. 846, 850


No. 878


 


SEQ ID
IGVAILDTQNGESWDYNGDQR
40-60 for the proteins of SEQ No. 849, 851


No. 879


 


SEQ ID
IGVSVLDTQNGEYWDYNGNQR
40-60 for the proteins of SEQ No. 845, 847,


No. 880

848, 852; 56-76 for the protein of sequence




SEQ ID No. 842; 56-76 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
KPIIVSIYLAQTEASMAER
250-268 for the proteins of SEQ No. 849,


No. 881

851


 


SEQ ID
KPIVAALYITETDASFEER
258-276 for the proteins of SEQ No. 846,


No. 882

850


 


SEQ ID
LESWMVNNQVTGNLLR
202-217 for the proteins of SEQ No. 845,


No. 883

847, 848, 849, 851, 852; 218-233 for the




protein of sequence SEQ ID No. 842; 218-233




for the protein of sequence SEQ ID No.




843


 


SEQ ID
LEYWMVNNQVTGNLLR
202-217 for the protein of SEQ No. 844


No. 884


 


SEQ ID
LGDLR
169-173 for the proteins of SEQ No. 844,


No. 885

845, 847, 848, 849, 851, 852; 185-189 for




the protein of sequence SEQ ID No. 842;




185-189 for the protein of sequence SEQ




ID No. 843


 


SEQ ID
LLFGSALSEMNQK
204-216 for the protein of SEQ No. 843


No. 886


 


SEQ ID
LLIDETLSIK
196-205 for the proteins of SEQ No. 846,


No. 887

850


 


SEQ ID
LLLVFSLLIPSMVFANSSK
3-21 for the protein of SEQ No. 844


No. 888


 


SEQ ID
LLYDAEHGK
75-83 for the proteins of SEQ No. 849, 851


No. 889


 


SEQ ID
LLYDAEQGEINPK
75-87 for the protein of SEQ No. 844


No. 890


 


SEQ ID
LLYDAEQGK
75-83 for the proteins of SEQ No. 845, 847,


No. 891

848, 852; 91-99 for the protein of sequence




SEQ ID No. 842; 91-99 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
MCDNQNYGVTYMK
6-18 for the proteins of SEQ No. 842, 843


No. 892


 


SEQ ID
NAVIAK
277-282 for the proteins of SEQ No. 846,


No. 893

850


 


SEQ ID
NDAIVK
269-274 for the proteins of SEQ No. 844,


No. 894

845, 847, 848, 849, 851, 852; 285-290 for




the protein of sequence SEQ ID No. 842;




285-290 for the protein of sequence SEQ




ID No. 843


 


SEQ ID
QIGDK
149-153 for the proteins of SEQ No. 844,


No. 895

845, 847, 848, 849, 851, 852; 165-169 for




the protein of sequence SEQ ID No. 842;




165-169 for the protein of sequence SEQ




ID No. 843


 


SEQ ID
QQLESWLK
208-215 for the proteins of SEQ No. 846,


No. 896

850


 


SEQ ID
QVEQDVK
24-30 for the proteins of SEQ No. 845, 847,


No. 897

848, 852; 40-46 for the protein of sequence




SEQ ID No. 842; 40-46 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
SGAGGFGAR
230-238 for the proteins of SEQ No. 844,


No. 898

845, 847, 848, 849, 851, 852; 246-254 for




the protein of sequence SEQ ID No. 842;




246-254 for the protein of sequence SEQ




ID No. 843


 


SEQ ID
SIGDDTTR
157-164 for the proteins of SEQ No. 846,


No. 899

850


 


SEQ ID
SITAIVWSEEK
239-249 for the proteins of SEQ No. 845,


No. 900

849, 851


 


SEQ ID
SITDFLR
142-148 for the proteins of SEQ No. 849,


No. 901

851


 


SEQ ID
SLLVFALLMPSVVFASSSK
3-21 for the proteins of SEQ No. 849, 851


No. 902


 


SEQ ID
STIEIK
88-93 for the protein of SEQ No. 844


No. 903


 


SEQ ID
SVLPAGWNIADR
218-229 for the proteins of SEQ No. 847,


No. 904

848, 852; 234-245 for the protein of




sequence SEQ ID No. 842; 234-245 for the




protein of sequence SEQ ID No. 843


 


SEQ ID
SVLPEGWNIADR
218-229 for the protein of SEQ No. 844


No. 905


 


SEQ ID
SVLPVK
218-223 for the proteins of SEQ No. 845,


No. 906

849


 


SEQ ID
SVLPVTWSIADR
218-229 for the protein of SEQ No. 851


No. 907


 


SEQ ID
TGAGGYGSR
238-246 for the proteins of SEQ No. 846,


No. 908

850


 


SEQ ID
TIACAK
69-74 for the proteins of SEQ No. 844, 845,


No. 909

847, 848, 849, 851, 852; 85-90 for the




protein of sequence SEQ ID No. 842; 85-90




for the protein of sequence SEQ ID No. 843


 


SEQ ID
TIIVSIYLAQTEASMAER
251-268 for the protein of SEQ No. 845


No. 910


 


SEQ ID
TILMENSR
290-297 for the protein of SEQ No. 850


No. 911


 


SEQ ID
TLACANVLQR
76-85 for the proteins of SEQ No. 846, 850


No. 912


 


SEQ ID
TVLMENSR
290-297 for the protein of SEQ No. 846


No. 913


 


SEQ ID
VDLGK
86-90 for the proteins of SEQ No. 846, 850


No. 914


 


SEQ ID
VEPELNEGK
160-168 for the proteins of SEQ No. 849,


No. 915

851


 


SEQ ID
VNLNSTVEIK
84-93 for the protein of SEQ No. 849


No. 916


 


SEQ ID
VNLNSTVEVK
84-93 for the protein of SEQ No. 851


No. 917


 


SEQ ID
VNPNSTVEIK
84-93 for the proteins of SEQ No. 845, 848,


No. 918

852; 100-109 for the protein of sequence




SEQ ID No. 842; 100-109 for the protein of




sequence SEQ ID No. 843


 


SEQ ID
VNSNSTVEIK
84-93 for the protein of SEQ No. 847


No. 919


 


SEQ ID
WETELNEAVPGDK
168-180 for the proteins of SEQ No. 846,


No. 920

850


 


SEQ ID
WSIADR
224-229 for the proteins of SEQ No. 845,


No. 921

849, 851









The detection of a mechanism of resistance to cephalosporins induced by the expression of the DHA protein is characterised by the detection of at least one peptide belonging to the DHA protein and to its different sequence variants SEQ ID No. 922 to SEQ ID No. 927.







SEQ ID No. 922:


MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVA


 


VSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKK


 


EMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDAVKNRAEL


 


LHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAP


 


LGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDML


 


RWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKD


 


MIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEK


 


QVAIVILANKNYPNTERVKAAQAILSALE


 


SEQ ID No. 923:


MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVA


 


VSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKK


 


EMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADL


 


LNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAP


 


LGLSHTFITVPDSAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDML


 


RWAEMNIEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKD


 


MIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEK


 


QVAIVILANKNYPNTERVKAAQAILSALE


 


SEQ ID No. 924:


MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVA


 


VSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKK


 


EMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADL


 


LNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAP


 


LGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDML


 


RWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKD


 


MIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGSGAYVAFIPEK


 


QVAIVILANKNYPNTERVKAAQAILSALE


 


SEQ ID No. 925:


MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVA


 


VSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKK


 


EMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADL


 


LNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAP


 


LGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSTSKDML


 


RWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKD


 


MIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEK


 


QVAIVILANKNYPNTERVKAAQAILSALE


 


SEQ ID No. 926:


MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVA


 


VSVKGRPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKK


 


EMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADL


 


LHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAP


 


LGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDML


 


RWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKD


 


MIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEK


 


QVAIVILANKNYPNTERVKAAQAILSALE


 


SEQ ID No. 927:


MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVA


 


VSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKK


 


EMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADL


 


LNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAP


 


LGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDML


 


RWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKD


 


MIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEK


 


QVAIVILANKNYPNTERVKAAQAILSALE






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 928 to SEQ ID No. 948 as defined hereafter:












Peptide




SEQ ID


No.
Amino acid sequence
Position of the peptide in the DHA protein(s)







SEQ ID
ADLLHFYQQWQPSR
148-161 for the protein of SEQ No. 926


No. 928


 


SEQ ID
ADLLNFYQQWQPSR
148-161 for the proteins of SEQ No. 923, 924,


No. 929

925, 927


 


SEQ ID
AELLHFYQQWQPSR
148-161 for the protein of SEQ No. 922


No. 930


 


SEQ ID
AGNADLEMAMYLAQTR
262-277 for the proteins of SEQ No. 922, 923,


No. 931

924, 925, 926, 927


 


SEQ ID
EMALNDPAAK
101-110 for the proteins of SEQ No. 923, 924,


No. 932

925, 926, 927


 


SEQ ID
EMMLNDPAEK
101-110 for the protein of SEQ No. 922


No. 933


 


SEQ ID
GKPYYFNYGFADIQAK
55-70 for the proteins of SEQ No. 923, 924,


No. 934

925, 927


 


SEQ ID
GKPYYFNYGFADVQAK
55-70 for the protein of SEQ No. 922


No. 935


 


SEQ ID
KPGDMR
162-167 for the proteins of SEQ No. 922, 923,


No. 936

924, 925, 926, 927


 


SEQ ID
NYPNTER
361-367 for the proteins of SEQ No. 922, 923,


No. 937

924, 925, 926, 927


 


SEQ ID
QPVTENTLFELGSVSK
71-86 for the proteins of SEQ No. 922, 923,


No. 938

924, 925, 926, 927


 


SEQ ID
QVAIVILANK
351-360 for the proteins of SEQ No. 922, 923,


No. 939

924, 925, 926, 927


 


SEQ ID
TAAINQGLGWEMYDWPQQK
281-299 for the proteins of SEQ No. 922, 923,


No. 940

924, 925, 926, 927


 


SEQ ID
TFTGVLGAVSVAK
87-99 for the proteins of SEQ No. 922, 923,


No. 941

924, 925, 926, 927


 


SEQ ID
TGATTGFGAYVAFIPEK
334-350 for the proteins of SEQ No. 922, 923,


No. 942

925, 926, 927


 


SEQ ID
TGATTGSGAYVAFIPEK
334-350 for the protein of SEQ No. 924


No. 943


 


SEQ ID
VSPGQLDAESYGVK
230-243 for the proteins of SEQ No. 922, 923,


No. 944

924, 925, 926, 927


 


SEQ ID
WAEMNIEPSR
252-261 for the protein of SEQ No. 923


No. 945


 


SEQ ID
WAEMNMEPSR
252-261 for the proteins of SEQ No. 922, 924,


No. 946

925, 926, 927


 


SEQ ID
YQPELALPQWK
111-121 for the proteins of SEQ No. 922, 923,


No. 947

924, 925, 926, 927


 


SEQ ID
ASWVHK
328-333 for the proteins of SEQ No. 922, 923,


No. 948

924, 925, 926, 927









The detection of a mechanism of resistance to cephalosporins induced by the expression of the MIR protein is characterised by the detection of at least one peptide belonging to the MIR protein and to its different sequence variants SEQ ID No. 949 to SEQ ID No. 953.







SEQ ID No. 949:


MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFK


 


PLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDM


 


ASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYRILDALQ


 


SEQ ID No. 950:


MMTKSLSCALLLSVASAAFAAPMSETQLAEVVERTVTPLMNAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFK


 


PLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDM


 


ASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYHILDALQ


 


SEQ ID No. 951:


MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFK


 


PLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDM


 


ASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYRILDALQ


 


SEQ ID No. 952:


MMTKSLSCALLLSVASAAFAAPMFEKQLAEVVERTVTPLMNAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFK


 


PLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDM


 


ASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYRILDALQ


 


SEQ ID No. 953:


MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAV


 


AVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIAR


 


GEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTAS


 


LLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFK


 


PLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDM


 


ASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDA


 


KTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIP


 


EKQLGIVMLANKSYPNPARVEAAYRILDALQ






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 954 to SEQ ID No. 981 as defined hereafter:












Peptide




SEQ ID

Position of the peptide in the MIR


No.
Amino acid sequence
protein(s)







SEQ ID
AEEAHFAWGYR
214-224 for the protein of SEQ No. 949


No. 954


 


SEQ ID
DMASWLIANMK
249-259 for the proteins of SEQ No. 949,


No. 955

951, 952, 953


 


SEQ ID
DMASWLIANMKPDSLHAPSLK
249-269 for the proteins of SEQ No. 951, 952


No. 956


 


SEQ ID
DMASWLIANMKPDSLQAPSLK
249-269 for the proteins of SEQ No. 949, 953


No. 957


 


SEQ ID
DMASWVIANMK
249-259 for the protein of SEQ No. 950


No. 958


 


SEQ ID
DMASWVIANMKPDSLQAPSLK
249-269 for the protein of SEQ No. 950


No. 959


 


SEQ ID
GEIALGDPVAK
101-111 for the proteins of SEQ No. 949,


No. 960

950, 951, 952, 953


 


SEQ ID
TVVGGSDNK
302-310 for the proteins of SEQ No. 949,


No. 961

950, 951, 952, 953


 


SEQ ID
ADVAANK
66-72 for the proteins of SEQ No. 949, 950,


No. 962

951, 952, 953


 


SEQ ID
AEEAHYAWGYR
214-224 for the proteins of SEQ No. 950,


No. 963

951, 952, 953


 


SEQ ID
AVHVSPGMLDAEAYGVK
228-244 for the proteins of SEQ No. 949,


No. 964

950, 951, 952, 953


 


SEQ ID
FYQNWQPQWK
154-163 for the proteins of SEQ No. 949,


No. 965

950, 951, 952, 953


 


SEQ ID
FYQNWQPQWKPGTTR
154-168 for the proteins of SEQ No. 949,


No. 966

950, 951, 952, 953


 


SEQ ID
LDHTWINVPK
204-213 for the proteins of SEQ No. 949,


No. 967

950, 951, 952, 953


 


SEQ ID
LYANASIGLFGALAVK
169-184 for the proteins of SEQ No. 949,


No. 968

950, 951, 952, 953


 


SEQ ID
QGIALAQSR
270-278 for the proteins of SEQ No. 949,


No. 969

950, 951, 952, 953


 


SEQ ID
QLAEVVER
27-34 for the proteins of SEQ No. 949, 950,


No. 970

951, 952, 953


 


SEQ ID
QLGIVMLANK
353-362 for the proteins of SEQ No. 949,


No. 971

950, 951, 952, 953


 


SEQ ID
SYPNPAR
363-369 for the proteins of SEQ No. 949,


No. 972

950, 951, 952, 953


 


SEQ ID
TFTGVLGGDAIAR
88-100 for the proteins of SEQ No. 949, 950,


No. 973

951, 952, 953


 


SEQ ID
TGSTGGFGSYVAFIPEK
336-352 for the proteins of SEQ No. 949,


No. 974

950, 951, 952, 953


 


SEQ ID
VALAPLPVAEVNPPAPPVK
311-329 for the proteins of SEQ No. 949,


No. 975

950, 951, 952, 953


 


SEQ ID
VEAAYR
370-375 for the proteins of SEQ No. 949,


No. 976

951, 952, 953


 


SEQ ID
VFKPLK
198-203 for the proteins of SEQ No. 949,


No. 977

950, 951, 952, 953


 


SEQ ID
VGAMYQGLGWEMLNWPVDAK
282-301 for the proteins of SEQ No. 949,


No. 978

950, 951, 952, 953


 


SEQ ID
ASWVHK
330-335 for the proteins of SEQ No. 949,


No. 979

950, 951, 952, 953


 


SEQ ID
QWQGIR
120-125 for the proteins of SEQ No. 949,


No. 980

950, 951, 952, 953


 


SEQ ID
YWPELTGK
112-119 for the proteins of SEQ No. 949,


No. 981

950, 951, 952, 953









The detection of a mechanism of resistance to cephalosporins induced by the expression of the MOX protein is characterised by the detection of at least one peptide belonging to the MOX protein and to its different sequence variants SEQ ID No. 982 to SEQ ID No. 988.







SEQ ID No. 982:


MQQRQSILWGAVATLMWAGLAHAGETSPVDPLRPVVDASIQPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAY


 


AVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVD


 


SLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQ


 


TLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKT


 


SSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWERYAYP


 


VSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVP


 


AKGIGIVMLANRNYPIPARVKAAHAILTQLAR


 


SEQ ID No. 983:


MQQRQSILWGALATLMWAGLAHAGDTSAVDPLRPVVDASIRPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAY


 


AVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVD


 


SLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQ


 


TLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKT


 


SSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYP


 


VSEQTLLAGNSAEVILEANPTAAPRESGNLMLFNKTGSTSGFGAYVAFVP


 


AKGIGIVMLANRNYPIPARVKAAHAILTQLAR


 


SEQ ID No. 984:


MQQRQSILWGALATLMWAGLAHAGDKAATDPLRPVVDASIRPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAY


 


AVVQGGFELDDKASLFAPWLKGSAFDNITMGELATYSAGGLPLQFPEEVD


 


SLEKMQAYYRQWTPAYSRGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQ


 


TMLPGLGLYHTYLNVPEQPMGHYAYGYWKEDKPFRVTPAMLAEEPYGIKT


 


SSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYPYP


 


VSEQTLLAGNSPAMIYNANPAAPAPAAAGHPVLFKKTGSTNGFGAYVAFV


 


PAKGIGVVMLANRNYPNEGTLKAGHAILTQLAR


 


SEQ ID No. 985:


MQQRQSILWGVLPTLMWAGLAHAGDRAATDPLRPVVDASIRPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAY


 


AVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVD


 


SLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQ


 


TILPGLGLYHTYLNVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKT


 


SSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYP


 


VSEQTLLAGNSAAMIYNANPAAPAPAARGHPVLFNKTGSTNGFGAYVAFV


 


PAKGIGIVMLANRNSPIEGTLKAGHAILTQLAR


 


SEQ ID No. 986:


MQQRQSILWGALATLMWAGLVHAGDKAATDPLRPVVDASIRPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAY


 


AVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVD


 


SLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQ


 


TMLPGLGLYHTYLTVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKT


 


SSADLLRFVKANIGGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYP


 


VSEQTLLAGNSPAMIYNAIPAVPAPAAAGHPVLFNKTGSTNGFGAYVAFV


 


PAKGIGIVMLANRNSPIEARIKAAHAILTQLAR


 


SEQ ID No. 987:


MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAY


 


AVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVD


 


SSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQ


 


TLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKT


 


SSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYP


 


VTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSSNGFGAYVAFVP


 


ARGIGIVMLANRNYPIPARVKAAHAILAQLAG


 


SEQ ID No. 988:


MQQRQSILWGALATLMWAGLAHAGETSPVDPLRPVVDASIRPLLKEHRIP


 


GMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAY


 


AVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVD


 


SLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQ


 


TLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKT


 


SSADLLRFVKANISGVHDKALQQAISLTHKGHYSVGGMTQGLGWESYAYP


 


VSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVP


 


AKGIGIVMLANRNYPIPARVKAAHAILTQLAR






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 989 to SEQ ID No. 1037 as defined hereafter:












Peptide




SEQ ID


No.
Amino acid sequence
Position of the peptide in the MOX protein(s)







SEQ ID
AATDPLR
27-33 for the proteins of SEQ No. 984, 985, 986


No. 989


 


SEQ ID
AHYFNYGVADR
62-72 for the proteins of SEQ No. 982, 983, 984,


No. 990

985, 986, 988


 


SEQ ID
ANISGVDDK
261-269 for the proteins of SEQ No. 982, 983


No. 991


 


SEQ ID
ANISGVHDK
261-269 for the protein of SEQ No. 988


No. 992


 


SEQ ID
ASLFAPWLK
113-121 for the proteins of SEQ No. 984, 985,


No. 993

986


 


SEQ ID
AVGVSEQTLFEIGSVSK
75-91 for the proteins of SEQ No. 982, 983, 984,


No. 994

985, 986, 988


 


SEQ ID
EDKPFR
230-235 for the protein of SEQ No. 984


No. 995


 


SEQ ID
ESGNLMLFNK
326-335 for the protein of SEQ No. 983


No. 996


 


SEQ ID
ESGSQMLFNK
326-335 for the proteins of SEQ No. 982, 988


No. 997


 


SEQ ID
GHPVLFNK
329-336 for the proteins of SEQ No. 985, 986


No. 998


 


SEQ ID
GHYSVGGMTQGLGWER
281-296 for the protein of SEQ No. 982


No. 999


 


SEQ ID
GIGVVMLANR
354-363 for the protein of SEQ No. 984


No.


1000


 


SEQ ID
MQAYYR
155-160 for the proteins of SEQ No. 982, 983,


No.

984, 985, 986, 988


1001


 


SEQ ID
NSPIEAR
364-370 for the protein of SEQ No. 986


No.


1002


 


SEQ ID
NSPIEGTLK
364-372 for the protein of SEQ No. 985


No.


1003


 


SEQ ID
NYPNEGTLK
364-372 for the protein of SEQ No. 984


No.


1004


 


SEQ ID
QPFDR
192-196 for the proteins of SEQ No. 984, 985,


No.

986


1005


 


SEQ ID
QWTPAYSPGSHR
161-172 for the proteins of SEQ No. 982, 983,


No.

985, 986, 988


1006


 


SEQ ID
QWTPAYSR
161-168 for the protein of SEQ No. 984


No.


1007


 


SEQ ID
QYANPSIGLFGYLAASSMK
173-191 for the proteins of SEQ No. 984, 985,


No.

986


1008


 


SEQ ID
QYSNPSIGLFGHLAASSMK
173-191 for the proteins of SEQ No. 983, 988


No.


1009


 


SEQ ID
TGSSNGFGAYVAFVPAR
336-352 for the protein of SEQ No. 987


No.


1010


 


SEQ ID
TGSTNGFGAYVAFVPAK
337-353 for the proteins of SEQ No. 984, 985,


No.

986


1011


 


SEQ ID
TGSTSGFGAYVAFVPAK
336-352 for the proteins of SEQ No. 982, 983,


No.

988


1012


 


SEQ ID
TLTATLGAYAVVQGGFELDDK
92-112 for the protein of SEQ No. 984


No.


1013


 


SEQ ID
TLTATLGAYAVVQGSFELDDK
92-112 for the proteins of SEQ No. 985, 986


No.


1014


 


SEQ ID
VSPGMLADEAYGIK
236-249 for the proteins of SEQ No. 982, 983,


No.

988


1015


 


SEQ ID
VTPAMLAEEPYGIK
236-249 for the protein of SEQ No. 984


No.


1016


 


SEQ ID
VTPGMLADEAYGIK
236-249 for the proteins of SEQ No. 985, 986


No.


1017


 


SEQ ID
YAYPVSEQTLLAGNSAK
297-313 for the proteins of SEQ No. 982, 988


No.


1018


 


SEQ ID
ALQQAISLTHK
270-280 for the proteins of SEQ No. 982, 983,


No.

987, 988


1019


 


SEQ ID
ANIGGVDDK
261-269 for the protein of SEQ No. 987


No.


1020


 


SEQ ID
EDKPIR
230-235 for the proteins of SEQ No. 982, 983,


No.

985, 986, 987, 988


1021


 


SEQ ID
ESGASVSEQTLFEIGSVSK
73-91 for the protein of SEQ No. 987


No.


1022


 


SEQ ID
ESGSQVLFNK
326-335 for the protein of SEQ No. 987


No.


1023


 


SEQ ID
GAMQLDDK
105-112 for the proteins of SEQ No. 982, 983,


No.

987, 988


1024


 


SEQ ID
GIGIVMLANR
353-362 for the proteins of SEQ No. 982, 983,


No.

987, 988; 354-363 for the proteins of sequence


1025

SEQ ID No. 985, 986


 


SEQ ID
HAPWLK
116-121 for the proteins of SEQ No. 982, 983,


No.

987, 988


1026


 


SEQ ID
NYPIPAR
363-369 for the proteins of SEQ No. 982, 983,


No.

987, 988


1027


 


SEQ ID
QAMASYAYGYSK
218-229 for the proteins of SEQ No. 982, 983,


No.

987, 988


1028


 


SEQ ID
QWAPVYSPGSHR
161-172 for the protein of SEQ No. 987


No.


1029


 


SEQ ID
QYSNPSIGLFGHLAASSLK
173-191 for the proteins of SEQ No. 982, 987


No.


1030


 


SEQ ID
TLTATLGAYAVVK
92-104 for the protein of SEQ No. 987


No.


1031


 


SEQ ID
TSSADLLAFVK
250-260 for the protein of SEQ No. 987


No.


1032


 


SEQ ID
TSSADLLR
250-257 for the proteins of SEQ No. 982, 983,


No.

984, 985, 986, 988


1033


 


SEQ ID
VILEANPTAAPR
314-325 for the proteins of SEQ No. 982, 983,


No.

987, 988


1034


 


SEQ ID
VNPGMLADEAYGIK
236-249 for the protein of SEQ No. 987


No.


1035


 


SEQ ID
AHYFNYGVANR
62-72 for the protein of SEQ No. 987


No.


1036


 


SEQ ID
IPGMAVAVLK
49-58 for the proteins of SEQ No. 982, 983, 984,


No.

985, 986, 987, 988


1037









The detection of a mechanism of resistance to cephalosporins induced by the expression of the PER protein is characterised by the detection of at least one peptide belonging to the PER protein and to its different sequence variants SEQ ID No. 1038 to SEQ ID No. 1044.







SEQ ID No. 1038:


MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAV


 


WGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNR


 


AKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSLSDNVACDLLFELVGGP


 


AALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQ


 


KTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKT


 


AATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK


 


KLSALSPN


 


SEQ ID No. 1039:


MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAV


 


WGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNR


 


AKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHTDNVACDLLFELVGGP


 


AALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQ


 


KTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKT


 


AATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK


 


KLSALSPN


 


SEQ ID No. 1040:


MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKGQIESIVIGKKATVGVAV


 


WGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNR


 


AKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHSDNVACDLLFELVGGP


 


AALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQ


 


KTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKT


 


AATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK


 


KLSALSPN


 


SEQ ID No. 1041:


MNVIAKGVFTTTALLMLSLSSWVVSAQSPLLKEQIETIVTGKKATVGVAV


 


WGPDDLEPLLVNPFEKFPMQSVFKMHLAMLVLHQVDQGKLDLNKTVAVNR


 


AAVLQNTWSPMMKDHQGDEFTVTVQQLLQYSVSHSDNVACDLLFELVGGP


 


AALHAYIQSLGIKETEVVANEAQMHADDQVQYKNWTSMKAAAQLLRKFEQ


 


KKQLSETSQALLWKWMVETTTGPQRLKGLLPAGTVVAHKTGTSGVRAGKT


 


AATNDIGVIMLPDGRPLLVAVFVKDSAESARTNEAIIAQVAQAAYQFELK


 


KLSAVSPD


 


SEQ ID No. 1042:


MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAV


 


WGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNR


 


AKVLQNTWAPIMKAYQGDQFSVPVQQLLQYSVSHSDNVACDLLFELVGGP


 


AALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQ


 


KTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGVRAGKT


 


AATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQAAYQFELK


 


KLSALSPN


 


SEQ ID No. 1043:


MNVITKCVFTASALLMLGLSSFVVSAQSPLLKEQIETIVTGKKATVGVAV


 


WGPDDLEPLLLNPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQSVTVNR


 


AAVLQNTWSPMMKDHQGDEFTVAVQQLLQYSVSHSDNVACDLLFELVGGP


 


QALHAYIQSLGVKEAAVVANEAQMHADDQVQYQNWTSMKAAAQVLQKFEQ


 


KKQLSETSQALLWKWMVETTTGPQRLKGLLPAGTIVAHKTGTSGVRAGKT


 


AATNDAGVIMLPDGRPLLVAVFVKDSAESERTNEAIIAQVAQAAYQFELK


 


KLSAVSPD


 


SEQ ID No. 1044:


MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAV


 


WGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNR


 


AKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHSDNVACDLLFELVGGP


 


AALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQ


 


KTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKT


 


AATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK


 


KLSALSPN






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 1045 to SEQ ID No. 1077 as defined hereafter:












Peptide




SEQ ID

Position of the peptide in the PER


No.
Amino acid sequence
protein(s)







SEQ ID
AAAQLLR
190-196 for the proteins of SEQ No. 1041


No.


1045


 


SEQ ID
AAAQVLQK
190-197 for the proteins of SEQ No. 1043


No.


1046


 


SEQ ID
AAVLQNTWSPMMK
101-113 for the proteins of SEQ No. 1041,


No.

1043


1047


 


SEQ ID
DSAESAR
275-281 for the proteins of SEQ No. 1041


No.


1048


 


SEQ ID
DSAESER
275-281 for the proteins of SEQ No. 1043


No.


1049


 


SEQ ID
DSAESSR
275-281 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1050


 


SEQ ID
EQIESIVIGK
33-42 for the proteins of SEQ No. 1038,


No.

1039, 1042, 1044


1051


 


SEQ ID
EQIETIVTGK
33-42 for the proteins of SEQ No. 1041, 1043


No.


1052


 


SEQ ID
ETEVVANEAQMHADDQVQYK
164-183 for the proteins of SEQ No. 1041


No.


1053


 


SEQ ID
FPMQSVFK
67-74 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1041, 1042, 1043, 1044


1054


 


SEQ ID
GAAEILK
190-196 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1055


 


SEQ ID
GLLPAGTIVAHK
228-239 for the proteins of SEQ No. 1043


No.


1056


 


SEQ ID
GLLPAGTVVAHK
228-239 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1041, 1042, 1044


1057


 


SEQ ID
GQIESIVIGK
33-42 for the proteins of SEQ No. 1040


No.


1058


 


SEQ ID
LDLNK
90-94 for the proteins of SEQ No. 1041


No.


1059


 


SEQ ID
LDLNQSVTVNR
90-100 for the proteins of SEQ No. 1043


No.


1060


 


SEQ ID
LDLNQTVIVNR
90-100 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1061


 


SEQ ID
LHLAMLVLHQVDQGK
75-89 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1043, 1044


1062


 


SEQ ID
MHLAMLVLHQVDQGK
75-89 for the proteins of SEQ No. 1041


No.


1063


 


SEQ ID
NWTSMK
184-189 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1041, 1042, 1043, 1044


1064


 


SEQ ID
QLSETSQALLWK
203-214 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1041, 1042, 1043, 1044


1065


 


SEQ ID
TAATNDAGVIMLPDGR
250-265 for the proteins of SEQ No. 1043


No.


1066


 


SEQ ID
TAATNDIGVIMLPDGR
250-265 for the proteins of SEQ No. 1041


No.


1067


 


SEQ ID
TAATNDLGIILLPDGR
250-265 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1068


 


SEQ ID
TGTSGIK
240-246 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1044


1069


 


SEQ ID
TGTSGVR
240-246 for the proteins of SEQ No. 1041,


No.

1042, 1043


1070


 


SEQ ID
TNEAIIAQVAQAAYQFELK
282-300 for the proteins of SEQ No. 1041,


No.

1042, 1043


1071


 


SEQ ID
TNEAIIAQVAQTAYQFELK
282-300 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1044


1072


 


SEQ ID
TQLSETSQALLWK
202-214 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1073


 


SEQ ID
TVAVNR
95-100 for the proteins of SEQ No. 1041


No.


1074


 


SEQ ID
VLQNTWAPIMK
103-113 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1075


 


SEQ ID
WMVETTTGPER
215-225 for the proteins of SEQ No. 1038,


No.

1039, 1040, 1042, 1044


1076


 


SEQ ID
WMVETTTGPQR
215-225 for the proteins of SEQ No. 1041,


No.

1043


1077









The detection of a mechanism of resistance to cephalosporins induced by the expression of the PER protein indicates an ESBL resistance. It is preferably detected with the aid of SEQ ID No. 1045 to SEQ ID No. 1065 and SEQ ID No. 1069 to SEQ ID No. 1077.
The detection of a mechanism of resistance to cephalosporins induced by the expression of the VEB protein is characterised by the detection of at least one peptide belonging to the VEB protein and to its different sequence variants SEQ ID No. 1078 to SEQ ID No. 1084.







SEQ ID No. 1078:


MKIVKRILLVLLSLFFTIVYSNAQTDNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYY


 


LNK


 


SEQ ID No. 1079:


MKIVKRILLVLLSLFFTIVYSNAQADNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK


 


SEQ ID No. 1080:


MKIVKRILLVLLSLFFTVVYSNAQTDNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTFKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK


 


SEQ ID No. 1081:


MKIVKRILLVLLSLFFTIVYSNAQADNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKMWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK


 


SEQ ID No. 1082:


MKIVKRILLVLLSLFFTVEYSNAQTDNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKMWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK


 


SEQ ID No. 1083:


MKIVKRILLVLLSLFFTVVYSNAQADNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKMWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK


 


SEQ ID No. 1084:


MKIVKRILLVLLSLFFTVEYSNAQTDNLTLKIENVLKAKNARIGVAIFNS


 


NEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDL


 


LPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQ


 


KFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQ


 


LLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGITAA


 


TNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 1085 to SEQ ID No. 1104 as defined hereafter:












Peptide




SEQ ID


No.
Amino acid sequence
Position of the peptide in the VEB protein(s)







SEQ ID
ANEEQMHK
165-172 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1085


 


SEQ ID
DWNTQYQNWATPTAMNK
173-189 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1086


 


SEQ ID
ETSEINEK
276-283 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1087


 


SEQ ID
ETTTGSNR
216-223 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1088


 


SEQ ID
FLNANHFTDISIK
152-164 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1089


 


SEQ ID
FPIALAVLSEIDK
72-84 for the proteins of SEQ No. 1078, 1079, 1080,


No.

1081, 1082, 1083, 1084


1090


 


SEQ ID
GNLSFEQK
85-92 for the proteins of SEQ No. 1078, 1079, 1080,


No.

1081, 1082, 1083, 1084


1091


 


SEQ ID
GQLPK
226-230 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1092


 


SEQ ID
IEITPQDLLPK
93-103 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1093


 


SEQ ID
IENVLK
32-37 for the proteins of SEQ No. 1078, 1079, 1080,


No.

1081, 1082, 1083, 1084


1094


 


SEQ ID
IGVAIFNSNEK
43-53 for the proteins of SEQ No. 1078, 1079, 1080,


No.

1081, 1082, 1083, 1084


1095


 


SEQ ID
IISDIAK
284-290 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1096


 


SEQ ID
INNDFHFPMQSVMK
58-71 for the proteins of SEQ No. 1078, 1079, 1080,


No.

1081, 1082, 1083, 1084


1097


 


SEQ ID
LIGGTDSVQK
142-151 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1098


 


SEQ ID
LLIDTYNNK
190-198 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1099


 


SEQ ID
MWSPIK
104-109 for the proteins of SEQ No. 1081, 1082,


No.

1083


1100


 


SEQ ID
NQLLSK
199-204 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1101


 


SEQ ID
NTIVAHK
231-237 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1102


 


SEQ ID
SYDFIWK
206-212 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1081, 1082, 1083, 1084


1103


 


SEQ ID
TWSPIK
104-109 for the proteins of SEQ No. 1078, 1079,


No.

1080, 1084


1104









The detection of a mechanism of resistance to cephalosporins induced by the expression of the VEB protein indicates an ESBL resistance.
The detection of a mechanism of resistance to cephalosporins or to carbapenems induced by the expression of the OXA protein is characterised by the detection of at least one peptide belonging to the OXA protein and to its different sequence variants SEQ ID No. 1105 to SEQ ID No. 1266:








SEQ. ID. No. 1105:



MSRLLLSGLLATGLLCAVPASAASGCFLYADGNGQTLSSEGDCSSQLPPASTFKIPL


 


ALMGYDSGFLVNEEHPALPYKPSYDGWLPAWRETTTPRRWETYSVVWFSQQITE


 


WLGMERFQQYVDRFDYGNRDLSGNPGKHDGLTQAWLSSSLAISPEEQARFLGKM


 


VSGKLPVSAQTLQYTANILKVSEVEGWQIHGKTGMGYPKKLDGSLNRDQQIGWFV


 


GWASKPGKQLIFVHTVVQKPGKQFASIKAKEEVLAALPAQLKKL


 


SEQ ID No. 1106:


IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPA


 


STFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQI


 


AREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSA


 


SKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFF


 


AFNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1107:


MKKILLLHMLVFVSATLPISSVASDEVETLKCTIIADAITGNTLYETGECARRVSPCSS


 


FKLPLAIMGFDSGILQSPKSPTWELKPEYNPSPRDRTYKQVYPALWQSDSVVWFSQ


 


QLTSRLGVDRFTEYVKKFEYGNQDVSGDSGKHNGLTQSWLMSSLTISPKEQIQFLL


 


RFVAHKLPVSEAAYDMAYATIPQYQAAEGWAVHGKSGSGWLRDNNGKINESRPQ


 


GWFVGWAEKNGRQVVFARLEIGKEKSDIPGGSKAREDILVELPVLMGNK


 


SEQ ID No. 1108:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNAGPSTSNGDYWIEGSLAISAQE


 


QIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1109:


MQRSLSMSGKRHFIFAVSFVISTVCLTFSPANAAQKLSCTLVIDEASGDLLHREGSC


 


DKAFAPMSTFKLPLAIMGYDADILLDATTPRWDYKPEFNGYKSQQKPTDPTIWLKDS


 


IVWYSQELTRRLGESRFSDYVQRFDYGNKDVSGDPGKHNGLTHAWLASSLKISPEE


 


QVRFLRRFLRGELPVSEDALEMTKAVVPHFEAGDWDVQGKTGTGSLSDAKGGKAP


 


IGWFIGWATRDDRRVVFARLTVGARKGEQPAGPAARDEFLNTLPALSENF


 


SEQ ID No. 1110:


MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLAR


 


ASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVS


 


AVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLE


 


SLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVE


 


KETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1111:


IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPA


 


STFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIT


 


REVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSAS


 


KENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFA


 


FNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1112:


IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPA


 


STFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIA


 


REVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSAS


 


KENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFA


 


FNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1113:


MIIRFLALLFSAVVLVSLGHAQEKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTS


 


VYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQN


 


LRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISA


 


NEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGW


 


VEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN


 


SEQ ID No. 1114:


MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILV


 


FDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLR


 


SAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQ


 


IAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRIGWWVGWVEW


 


PTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1115:


MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFL


 


ESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWV


 


EKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1116:


MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLE


 


SLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVE


 


KGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1117:


MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFGLEGQLRISAVNQVEFLE


 


SLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVE


 


KGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1118:


MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKA


 


KCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFS


 


VVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQ


 


IQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEG


 


FIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL


 


SEQ ID No. 1119:


ANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNAEIAQFNKAKCATQMAPDSTF


 


KIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKI


 


GLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLP


 


VKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVF


 


VSALTGNLGSNLTSSIKAKKNAITIL


 


SEQ ID No. 1120:


IFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKR


 


YSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTV


 


WVYELFAKEIGDDKARRYLKKIDYGNAYPSTSNGDYWIEGSLAISAQEQIAFLRKLYR


 


NELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFA


 


LNIDTPNRMDDLFKREAIVRAIL


 


SEQ ID No. 1121:


MIIRFLALLFSAVVLVSLGHAQDKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTS


 


VYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQN


 


LRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISA


 


NEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGW


 


VEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN


 


SEQ ID No. 1122:


MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGK


 


NLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEK


 


DMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPL


 


KITPVQEVNFADDLAHNRLPFKLETQEEVEKMLLIKEVNGSKIYAKSGWGMGVTPQV


 


GWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKLLENLGII


 


SEQ ID No. 1123:


MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGK


 


NLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEK


 


DMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPL


 


KITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQV


 


GWLTGWVEQANGKKIPFSLNLEMKEGMTGSIRNEITYKSLENLGII


 


SEQ ID No. 1124:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKADINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1125:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYCIEGSLAISAQEQ


 


IAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAIL


 


SEQ ID No. 1126:


MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFL


 


ESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWV


 


EKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1127:


MAIRFLTILLSTFFLTSFVHAQEHVLERSDWKKFFSDLRAEGAIVISDERQAEHALLVF


 


GQERAAKRYSPASTFKLPHTLFALDADAVRDEFQVFRWDGVKRSFAGHNQDQDLR


 


SAMRNSAVWVYELFAKEIGKDKARHYLKQIDYGNADPSTIKGDYWIDGNLEISAHEQ


 


ISFLRKLYRNQLPFQVEHQRLVKDLMITEAGRNWILRAKTGWEGRFGWWVGWVE


 


WPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN


 


SEQ ID No. 1128:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSIAISAQEQ


 


IAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1129:


MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGK


 


NLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEK


 


DMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPL


 


KITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQV


 


GWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII


 


SEQ ID No. 1130:


MAIRFLTILLSTFFLTSFVHAQEHVLERSDWKKFFSDLRAEGAIVISDERQAEHALLVF


 


GQERAAKRYSPASTFKLPHTLFALDADAVRDEFQVFRWDGVKRSFAGHNQDQDLR


 


SAMRNSAVWVYELFAKEIGEDKARRYLKQIDYGNADPSTIKGDYWIDGNLEISAHEQ


 


ISFLRKLYRNQLPFQVEHQRLVKDLMITEAGRNWILRAKTGWEGRFGWWVGWVE


 


WPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN


 


SEQ ID No. 1131:


MAIRFFTILLSTFFLTSFVYAQEHVVIRSDWKKFFSDLQAEGAIVIADERQAKHTLSVF


 


DQERAAKRYSPASTFKIPHTLFALDADAVRDEFQVFRWDGVNRSFAGHNQDQDLR


 


SAMRNSTVWVYELFAKDIGEDKARRYLKQIDYGNVDPSTIKGDYWIDGNLKISAHEQ


 


ILFLRKLYRNQLPFKVEHQRLVKDLMITEAGRSWILRAKTGWEGRFGWWVGWIEW


 


PTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN


 


SEQ ID No. 1132:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVERIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAAMDIKPQ


 


VGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1133:


MAIQIFAILFSTFVLATFAHAQDGTLERSDWGKFFSDFQAKGTIVVADERQADHAILV


 


FDQARSMKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVKRSFAGHNKDQDLR


 


SAMRNSTVWVYELFAKEIGDGKARRYLKQIGYGNADPSTSHGDYWIEGSLAISAQE


 


QIAFLRKLYQNDLPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGSMGWWVGWV


 


EWPTGPVFFALNIDTPNRMDDLFKREAIARAILLSIEALPPNPAVHSDAAR


 


SEQ ID No. 1134:


MKNTIHINFAIFLIIANIIYSSASASTDISTVASQLFEGTEGCFLLYDASTNAEIAQFNKA


 


KCAAQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKIPKGMEIWNSNHTPKTWMQFS


 


VVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQ


 


IQFLRKIINHNLPVRNSAIENTIDNMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEG


 


FIISKSGHKYVFVSALTGSLGSNLTSSIKAKKNAITILNTLNL


 


SEQ ID No. 1135:


MLLFMFSIISFGNENQFMKEIFERKGLNGTFVVYDLKNDKIDYYNLDRANERFYPASS


 


FKIFNTLIGLENGIVKNVDEMFYYYDGSKVFLDSWAKDSNLRYAIKVSQVPAYKKLAR


 


ELGKERMQEGLNKLNYGNKEIGSEIDKFWLEGPLKISAMEQVKLLNLLSQSKLPFKL


 


ENQEQVKDITILEKKDDFILHGKTGWATDNIVVPIGWFVGWIETSDNIYSFAINLDISD


 


SKFLPKREEIVREYFKNINVIK


 


SEQ ID No. 1136:


MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGF


 


TNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLI


 


TAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATE


 


QISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGW


 


VELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP


 


SEQ ID No. 1137:


MLSRYSKTLAFAVVACTLAISTATAHAELVVRNDLKRVFDDAGVSGTFVLMDITADR


 


TYVVDPARAARSIHPASTFKIPNSLIAFDTGAVRDDQEVLPYGGKPQPYEQWEHDM


 


ALPEAIRLSAVPIYQEVARRVGFERMQAYVDAFDYGNRQLGSAIDQFWLRGPLEISA


 


FEEARFTSRMALKQLPVKPRTWDMVQRMLLIEQQGDAALYAKTGVATEYQPEIGW


 


WAGWVERAGHVYAFALNIDMPREGDMAKRIPLGKQLMRALEVWPAP


 


SEQ ID No. 1138:


MRPLLFSALLLLSGHTQASEWNDSQAVDKLFGAAGVKGTFVLYDVQRQRYVGHDR


 


ERAETRFVPASTYKVANSLIGLSTGAVRSADEVLPYGGKPQRFKAWEHDMSLRDAI


 


KASNVPVYQELARRIGLERMRANVSRLGYGNAEIGQVVDNFWLVGPLKISAMEQTR


 


FLLRLAQGELPFPAPVQSTVRAMTLLESGPGWELHGKTGWCFDCTPELGWWVGW


 


VKRNERLYGFALNIDMPGGEADIGKRVELGKASLKALGILP


 


SEQ ID No. 1139:


MNKGLHRKRLSKRLLLPMLLCLLAQQTQAVAAEQTKVSDVCSEVTAEGWQEVRRW


 


DKLFESAGVKGSLLLWDQKRSLGLSNNLSRAAEGFIPASTFKLPSSLIALETGAVRD


 


ETSRFSWDGKVREIAVWNRDQSFRTAMKYSVVPVYQQLAREIGPKVMAAMVRQLE


 


YGNQDIGGQADSFWLDGQLRITAFQQVDFLRQLHDNKLPVSERSQRIVKQMMLTE


 


ASTDYIIRAKTGYGVRRTPAIGWWVGWLELDDNTVYFAVNLDLASASQLPLRQQLV


 


KQVLKQEQLLP


 


SEQ ID No. 1140:


MNTIISRRWRAGLWRRLVGAVVLPATLAATPAAYAADVPKAALGRITERADWGKLF


 


AAEGVKGTIVVLDARTQTYQAYDAARAEKRMSPASTYKIFNSLLALDSGALDNERAII


 


PWDGKPRRIKNWNAAMDLRTAFRVSCLPCYQVVSHKIGRRYAQAKLNEVGYGNRT


 


IGGAPDAYWVDDSLQISAREQVDFVQRLARGTLPFSARSQDIVRQMSIVEATPDYVL


 


HGKTGWFVDKKPDIGWWVGWIERDGNITSVAINIDMLSEADAPKRARIVKAVLKDLK


 


LI


 


SEQ ID No. 1141:


MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVS


 


AVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLE


 


SLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVE


 


KGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1142:


MRVLALSAVLVVASIVGMPAMANEWQEKPSWNTHFSEHKAQGVIVLWNENKQQGF


 


TNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLI


 


TAMKYSVVPVYQEFARQIGQARMSKMLHAFDYGNEDISGNLDSFWLDGGIRISATE


 


QVAFLRKLYHNKLHVSERSQRIVKQAMLTEANSDYIIRAKTGYSTRIEPQIGWWVGW


 


VELDDNVWFFAMNMDMPTADGLGLRQAITKEVLKQEKIIP


 


SEQ ID No. 1143:


MKKITLFLLFLNLVFGQDKILNNWFKEYNTSGTFVFYDGKTWASNDFSRAMETFSPA


 


STFKIFNALIALDSGVIKTKKEIFYHYRGEKVFLSSWAQDMNLSSAIKYSNVLAFKEVA


 


RRIGIKTMQEYLNKLHYGNAKISKIDTFWLDNSLKISAKEQAILLFRLSQNSLPFSQEA


 


MNSVKEMIYLKNMENLELFGKTGFNDGQKIAWIVGFVYLKDENKYKAFALNLDIDKF


 


EDLYKREKILEKYLDELVKKVKNDG


 


SEQ ID No. 1144:


MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAE


 


QRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKLMAKSFLESWAKDSNLRYAIKNSQV


 


PAYKELARRIGIKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQ


 


NELQYPIEIQKAISDITITRANLHITLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYV


 


FALNIDNINSDDLAKRINIVKESLKALNLLK


 


SEQ ID No. 1145:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1146:


MNIQALLLITSAIFISACSPYIVTANPNYSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRIGYGNADIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGISSSVRKEITYRGLEQLGIL


 


SEQ ID No. 1147:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKGEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1148:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1149:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1150:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQEVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1151:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1152:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQHEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1153:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKTTTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1154:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTAVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGTPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1155:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLPRRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1156:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEKLGIL


 


SEQ ID No. 1157:


MNIKTLLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASIEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKD


 


MTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKIT


 


PQQEAQFAYKLANKTLPFSLKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVG


 


WLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1158:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAISVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLAGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1159:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASALPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPL


 


KITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1160:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGSVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1161:


MNIKTLLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASIEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKD


 


MTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKIT


 


PQQEAQFAYKLANKTLPFSLKAQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVG


 


WLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1162:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1163:


MNIKTLLLITSAIFISACSHYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFTYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1164:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1165:


MNIKALLLITSTIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALISLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1166:


MNIQALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPHGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1167:


MNIKALFLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1168:


MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTY


 


DGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWD


 


KDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQMGTEVDQFWLKGP


 


LTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVD


 


PQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL


 


SEQ ID No. 1169:


MNIKALLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSLKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1170:


MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIRQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEMNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1171:


MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISGDAVFVTY


 


DGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWD


 


KDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPL


 


TITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDP


 


QVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL


 


SEQ ID No. 1172:


MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGK


 


NLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEK


 


DMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPL


 


KITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQV


 


GWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII


 


SEQ ID No. 1173:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIESSLAISAQE


 


QIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1174:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1175:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1176:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1177:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1178:


MNIKALLLITSAIFISACSPYIVTTNPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNTDIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1179:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIQVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1180:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEK


 


NMTLGDAMKASALPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPL


 


KITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1181:


MNIKTLLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEMNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1182:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFPLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1183:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGGDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1184:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1185:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1186:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKTTTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1187:


MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAE


 


QRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQ


 


VPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLA


 


QNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNI


 


YVFALNIDNINSDDLAKRINIVKESLKALNLLK


 


SEQ ID No. 1188:


MSKKNFILIFIFVILTSCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERA


 


EQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNS


 


QVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKL


 


AQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDN


 


IYVFALNIDNINSDDLAKRINIVKESLKALNLLK


 


SEQ ID No. 1189:


LLITSAIFISACSPYIVSANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIQQGQTQQSY


 


GNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLG


 


DAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQ


 


EAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLT


 


GWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSL


 


SEQ ID No. 1190:


LLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSY


 


GNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLG


 


DAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQ


 


EAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLT


 


EWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSL


 


SEQ ID No. 1191:


MTVRRLSCALGAALSLSALGGGPVQAAVLCTVVADAADGRILFQQGTQQACAERYT


 


PASTFKLAIALMGADAGILQGPHEPVWNYQPAYPDWGGDAWRQPTDPARWIKYSV


 


VWYSQLTAKALGQDRFQRYTSAFGYGNADVSGEPGKHNGTDGAWIISSLRISPLEQ


 


LAFLRKLVNRQLPVKAAAYELAENLFEAGQADGWRLYGKTGTGSPGSNGVYTAAN


 


AYGWFVGWARKDGRQLVYARLLQDERATRPNAGLRARDELVRDWPAMAGAWRP


 


SEQ ID No. 1192:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNVLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQEVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1193:


MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLAR


 


ASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVS


 


AVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLES


 


LYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEK


 


ETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1194:


MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1195:


MNIKALLLITSAIFISACSPYIVTTNPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNTDIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1196:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPL


 


KITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNQ


 


QVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1197:


MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEMTYKSLEQLGIL


 


SEQ ID No. 1198:


MNKYFTCYVVASLFFSGCTVQHNLINETQSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTTWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVERIDFGNAEIGQQVDNFWLIGPLK


 


VTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEENNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1199:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAAMDIKPQ


 


VGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1200:


MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFLLEGQLRISAVNQVEFLE


 


SLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVE


 


KGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1201:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGDADPSTSNGDYWIEGSLAISAQE


 


QIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1202:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKASTTEVFKWNGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVKSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1203:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKHVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1204:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKHVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1205:


MKKFILPILSISTLLSVSACSSIQTKFEDTFHTSNQQHEKAIKSYFDEAQTQGVIIIKKG


 


KNISTYGNNLTRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEK


 


DMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPL


 


KITPIQEVNFADDFANNRLPFKLETQEEVKKMLLIKEFNGSKIYAKSGWGMDVTPQV


 


GWLTGWVEKSNGEKVAFSLNIEMKQGMPGSIRNEITYKSLENLGII


 


SEQ ID No. 1206:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQEVQDEVQSILFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1207:


MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGK


 


NLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEK


 


DMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPL


 


KITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTSQV


 


GWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII


 


SEQ ID No. 1208:


MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGF


 


TNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLI


 


TAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATE


 


QISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSARIEPKIGWWVGW


 


VELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP


 


SEQ ID No. 1209:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPL


 


KITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVNPQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1210:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPL


 


KITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVNLQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1211:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEKLGIL


 


SEQ ID No. 1212:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIRNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1213:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDSKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1214:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDGVQSMLFIEEKNGNKIYAKSGWGWDVNPQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1215:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDSKKRLFPEWEK


 


DMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1216:


MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTY


 


DGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFLKAWD


 


KDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPL


 


TITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDP


 


QVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL


 


SEQ ID No. 1217:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDVKPQ


 


VGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1218:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGALVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1219:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELMMKSLKQLNII


 


SEQ ID No. 1220:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLAGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1221:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDERNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1222:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEKSNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1223:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASTRNELLMKSLKQLNII


 


SEQ ID No. 1224:


MKKFILPIFSISILLSLSACSSIQTKFEDTFHISNQKHEKAIKSYFDEAQTQGVIIIKEGKN


 


ISSYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRSYPMWEKD


 


MTLGEAMALSAVPVYQDLARRIGLNLMQKEVKRVGFGNMNIGTQVDNFWLIGPLKI


 


TPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVSPQVG


 


WLTGWVEKSNGEKVSFSLNIEMKQGMSGSIRNEITYKSLENLGII


 


SEQ ID No. 1225:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIAVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1226:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAIKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1227:


MKILIFLPLLSCLGLTACSLPVSSLPSQSISTQAIASLFDQAQSSGVLVIQRDQQVQVY


 


GNDLNRANTEYVPASTFKMLNALIGLQHGKATTNEIFKWDGKKRSFTAWEKDMTLG


 


QAMQASAVPVYQELARRIGLELMQQEVQRIQFGNQQIGQQVDNFWLVGPLKVTPK


 


QEVQFVSALAREQLAFDPQVQQQVKAMLFLQERKAYRLYVKSGWGMDVEPQVGW


 


LTGWVETPQAEIVAFSLNMQMQNGIDPAIRLEILQQALAELGLYPKAEG


 


SEQ ID No. 1228:


MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRA


 


KQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCV


 


WCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKV


 


HLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDV


 


WFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE


 


SEQ ID No. 1229:


MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGTDKFWLEDQLRISAVNQVEFL


 


ESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWV


 


EKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1230:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1231:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIQVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1232:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAMPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPL


 


KITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1233:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1234:


MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGF


 


TNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLI


 


TAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATE


 


QISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYDTKIGWWVGWVELD


 


DNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP


 


SEQ ID No. 1235:


MSKKNFILIFIFVILISCKNTEKTSNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERA


 


EQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNS


 


QVPAYKELARRIGLEKMKENIEKLDFGNKNIGDSVDTFWLEGPLEISAMEQVKLLTKL


 


AQNELPYPIEIQKAVSDITILEQTDNYTLHGKTGLADSENMTTEPIGWLVGWLEENNN


 


IYVFALNIDNINSDDLAKRINIVKESLKALNLLK


 


SEQ ID No. 1236:


MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1237:


MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPSSQKVQDEVQSMLFIEEKNGNKMYAKSGWGWDVNPQ


 


VGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1238:


MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEIAYKSLEQLGIL


 


SEQ ID No. 1239:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDCWIEGSLAISAQE


 


QIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1240:


MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1241:


MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEYHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1242:


MAIRFLTILLSTFFLTSFVHAQEHVVVRSDWKKFFSDLQAEGAIVIADERQAEHALLV


 


FGQERAAKRYSPASTFKLPHTLFALDAGAVRDEFQVFRWDGVKRSFAGHNQDQDL


 


RSAMRNSAVWVYELFAKEIGEDNARRYLKQIDYGNADPSTIKGNYWIDGNLEISAHE


 


QISFLRKLYRNQLPFQVEHQRLVKYLMITEAGRNWILRAKTGWEGRFGWWIGWVE


 


WPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN


 


SEQ ID No. 1243:


MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGF


 


TNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLI


 


TAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATQ


 


QIAFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGW


 


VELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP


 


SEQ ID No. 1244:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKSQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1245:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAISVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1246:


MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLV


 


FDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLR


 


SAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQE


 


QIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1247:


MKTIAAYLVLVFYASTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNAA


 


RASTAYIPASTFKIPNALIGLETGAIKDERQVFKWDGKPRAMKQWEKDLKLRGAIQV


 


SAVPVFQQIAREVGEIRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAFNQVKFLE


 


SLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESSPGVAWWVGWVE


 


KGTEVYFFAFNMDIDNESKLPSRKSISTKIMASEGIIIGG


 


SEQ ID No. 1248:


MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKLACATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVS


 


AVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLE


 


SLFLNKLSASKENQLIVKEALVTEAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEK


 


GAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1249:


MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILV


 


FDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLR


 


SAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQ


 


IAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVE


 


WPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR


 


SEQ ID No. 1250:


MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLAR


 


ASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVS


 


AVPVFQQIAREVGEVRMQKYLKKFSYGSQNISGGIDKFWLEDQLRISAVNQVEFLES


 


LYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEK


 


ETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1251:


MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQT


 


DKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWE


 


KDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPL


 


KVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQV


 


GWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII


 


SEQ ID No. 1252:


MKKLSVLLWLTLFYCGTIWAQSTCFLVQENQTVLKHEGKDCNKRFAPESTFKIALSL


 


MGFDSGILKDTLNPEWPYKKEYELYLNVWKYPHNPRTWIRDSCVWYSQVLTQQLG


 


MTRFKNYVDAFHYGNQDISGDKGQNNGLTHSWLSSSLAISPSEQIQFLQKIVNKKLS


 


VNPKAFTMTKDILYIQELAGGWKLYGKTGNGRQLTKDKSQKLSLQHGWFIGWIEKD


 


GRVITFTKHIADSKKHVTFASFRAKNETLNQLFYLINELEK


 


SEQ ID No. 1253:


MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1254:


MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIA


 


ISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQV


 


AHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGK


 


MLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGW


 


FVGWIVRGNQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR


 


SEQ ID No. 1255:


MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIA


 


ISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYPVVWYSQQV


 


AHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGK


 


MLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGW


 


FVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR


 


SEQ ID No. 1256:


MRGKHTVILGAALSALFAGAAGAQMLECTLVADAASGQELYRKGACDKAFAPMSTF


 


KVPLAVMGYDAGILVDAHNPRWDYKPEFNGYKFQQKTTDPTIWEKDSIVWYSQQLT


 


RKMGQKRFAAYVAGFGYGNGDISGEPGKSNGLTHSWLGSSLKISPEGQVRFVRDL


 


LSAKLPASKDAQQMTVSILPHFAAGDWAVQGKTGTGSFIDARGAKAPLGWFIGWAT


 


HEERRVVFARMTAGGKKGEQPAGPAARDAFLKALPDLAKRF


 


SEQ ID No. 1257:


MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIA


 


ISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQV


 


AHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGK


 


MLDRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGW


 


FVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR


 


SEQ ID No. 1258:


MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIA


 


ISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQV


 


AHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGK


 


MLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGW


 


FVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR


 


SEQ ID No. 1259:


MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLAR


 


ASKEYLPVSTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVS


 


AVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLE


 


SLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVE


 


KETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG


 


SEQ ID No. 1260:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1261:


MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


NMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1262:


MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKSCATNNLA


 


RASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQV


 


SAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFL


 


ESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWV


 


EKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG


 


SEQ ID No. 1263:


MKTIAAYLVLVFFAGTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNAT


 


RASTAYIPASTFKIPNALIGLETGAIKDARQVFKWDGKPRAMKQWEKDLTLRGAIQV


 


SAVPVFQQIARDIGKKRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAVNQVKFLE


 


SLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESNPGVAWWVGWVE


 


KGTEVYFFAFNMDIDNESKLPSRKSIPTKIMASEGIIIGG


 


SEQ ID No. 1264:


MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGK


 


NLSTYGNALARANKEYVPASTFKMLIALIGLENHKATTNEIFKWDGKKRTYPMWEKD


 


MTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKI


 


TPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVG


 


WLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII


 


SEQ ID No. 1265:


MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEK


 


DMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLK


 


ITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV


 


GWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL


 


SEQ ID No. 1266:


MNIKALLLITSAISISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQ


 


TQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEK


 


DMTLGDAIKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKI


 


TPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 1267 to SEQ ID No. 1835 and SEQ ID No. 2160 to SEQ ID No. 2171 as defined hereafter:













Peptide





SEQ ID


Clinical


No.
Amino acid sequence
Position of the peptide in the OXA protein(s)
interest







SEQ ID
AAAYELAENLFEAGQADG
183-202 for the proteins of SEQ No. 1191
2d


No. 1267
WR


 


SEQ ID
AAEGFIPASTFK
86-97 for the proteins of SEQ No. 1139
2df


No. 1268


 


SEQ ID
AALGR
41-45 for the proteins of SEQ No. 1140
2df


No. 1269


 


SEQ ID
ADGQVVAFALNMQMK
241-255 for the proteins of SEQ No. 1168,
2df


No. 1270

1171, 1216


 


SEQ ID
ADINEIFK
95-102 for the proteins of SEQ No. 1124
2df


No. 1271


 


SEQ ID
ADWGK
50-54 for the proteins of SEQ No. 1140
2df


No. 1272


 


SEQ ID
AEGAIVISDER
40-50 for the proteins of SEQ No. 1127, 1130
OXA


No. 1273


 


SEQ ID
AFALNLDIDK
222-231 for the proteins of SEQ No. 1143
2d


No. 1274


 


SEQ ID
AFAPMSTFK
49-57 for the proteins of SEQ No. 1256; 60-68
OXA


No. 1275

for the protein of sequence SEQ ID No. 1109


 


SEQ ID
AFGYGNADVSGDPGQNNG
127-147 for the proteins of SEQ No. 1254,
2d


No. 1276
LDR
1255, 1257, 1258


 


SEQ ID
AFTMTK
174-179 for the proteins of SEQ No. 1252
2de


No. 1277


 


SEQ ID
AGDDIALR
256-263 for the proteins of SEQ No. 1168,
2df


No. 1278

1171, 1216


 


SEQ ID
AGHVYAFALNIDMPR
233-247 for the proteins of SEQ No. 1137
2df


No. 1279


 


SEQ ID
AGLWR
11-15 for the proteins of SEQ No. 1140
2df


No. 1280


 


SEQ ID
AHTEYVPASTFK
73-84 for the proteins of SEQ No. 1205, 1224
2df


No. 1281


 


SEQ ID
AIIPWDGK
112-119 for the proteins of SEQ No. 1140
2df


No. 1282


 


SEQ ID
AIIPWDGKPR
112-121 for the proteins of SEQ No. 1140
2df


No. 1283


 


SEQ ID
AISDITITR
190-198 for the proteins of SEQ No. 1144
2d


No. 1284


 


SEQ ID
AISGK
82-86 for the proteins of SEQ No. 1228
2df


No. 1285


 


SEQ ID
ALGQDR
121-126 for the proteins of SEQ No. 1191
2d


No. 1286


 


SEQ ID
ALPDLAK
256-262 for the proteins of SEQ No. 1256
2d


No. 1287


 


SEQ ID
ALQAK
254-258 for the proteins of SEQ No. 1228
2df


No. 1288


 


SEQ ID
AMETFSPASTFK
50-61 for the proteins of SEQ No. 1143
2d


No. 1289


 


SEQ ID
AMLFLQER
196-203 for the proteins of SEQ No. 1227
2df


No. 1290


 


SEQ ID
AMLVFDPVR
55-63 for the proteins of SEQ No. 1108, 1125,
OXA


No. 1291

1128, 1173, 1201, 1239, 1246; 44-52 for the




protein of sequence SEQ ID No. 1120


 


SEQ ID
AMTLLESGPGWELHGK
189-204 for the proteins of SEQ No. 1138
2d


No. 1292


 


SEQ ID
ANLHITLHGK
199-208 for the proteins of SEQ No. 1144
2d


No. 1293


 


SEQ ID
ANQLIVK
183-189 for the proteins of SEQ No. 1247,
OXA


No. 1294

1263


 


SEQ ID
ANTEYVPASTFK
71-82 for the proteins of SEQ No. 1124, 1132,
2df


No. 1295

1145, 1198, 1199, 1217, 1218, 1219, 1220,




1221, 1222, 1223, 1244, 1251; 66-77 for the




protein of sequence SEQ ID No. 1227


 


SEQ ID
ANVSR
133-137 for the proteins of SEQ No. 1138
2d


No. 1296


 


SEQ ID
APIGWFIGWATR
224-235 for the proteins of SEQ No. 1109
2de


No. 1297


 


SEQ ID
APLGWFIGWATHEER
213-227 for the proteins of SEQ No. 1256
2d


No. 1298


 


SEQ ID
AQDEVQSMLFIEEK
196-209 for the proteins of SEQ No. 1161
2df


No. 1299


 


SEQ ID
AQGVIVLWNENK
40-51 for the proteins of SEQ No. 1142
2df


No. 1300


 


SEQ ID
ASAIAVYQDLAR
126-137 for the proteins of SEQ No. 1225
2df


No. 1301


 


SEQ ID
ASAILVYQDLAR
126-137 for the proteins of SEQ No. 1175,
2df


No. 1302

1184, 1215, 1230


 


SEQ ID
ASAIPVYQDLAR
126-137 for the proteins of SEQ No. 1146,
2df


No. 1303

1147, 1148, 1149, 1150, 1151, 1152, 1153,




1154, 1156, 1157, 1160, 1161, 1162, 1163,




1164, 1165, 1166, 1167, 1169, 1170, 1174,




1176, 1177, 1178, 1181, 1182, 1183, 1185,




1186, 1192, 1194, 1195, 1197, 1202, 1203,




1204, 1206, 1211, 1212, 1213, 1214, 1226,




1233, 1236, 1237, 1238, 1240, 1241, 1253,




1260, 1261, 1265, 1266; 120-131 for the




protein of sequence SEQ ID No. 1189; 120-131




for the protein of sequence SEQ ID No. 1190


 


SEQ ID
ASAIPVYQDLPR
126-137 for the proteins of SEQ No. 1155
2df


No. 1304


 


SEQ ID
ASAIQVYQDLAR
126-137 for the proteins of SEQ No. 1179,
2df


No. 1305

1231


 


SEQ ID
ASAISVYQDLAR
126-137 for the proteins of SEQ No. 1158,
2df


No. 1306

1245


 


SEQ ID
ASALPVYQDLAR
126-137 for the proteins of SEQ No. 1159,
2df


No. 1307

1180


 


SEQ ID
ASAMPVYQDLAR
126-137 for the proteins of SEQ No. 1232
2df


No. 1308


 


SEQ ID
ASAVPVYQDLAR
126-137 for the proteins of SEQ No. 1196,
2df


No. 1309

1209, 1210


 


SEQ ID
ASIEYVPASTFK
72-83 for the proteins of SEQ No. 1157, 1161
2df


No. 1310


 


SEQ ID
ASNVPVYQELAR
113-124 for the proteins of SEQ No. 1138
2d


No. 1311


 


SEQ ID
ASPASTFK
49-56 for the proteins of SEQ No. 1254, 1255,
2d


No. 1312

1257, 1258


 


SEQ ID
ASTAYIPASTFK
59-70 for the proteins of SEQ No. 1247, 1263
OXA


No. 1313


 


SEQ ID
ASTEYVPASTFK
72-83 for the proteins of SEQ No. 1146, 1147,
2df


No. 1314

1148, 1149, 1150, 1151, 1152, 1153, 1154,




1155, 1156, 1158, 1159, 1160, 1162, 1163,




1164, 1165, 1166, 1167, 1169, 1170, 1174,




1175, 1176, 1177, 1178, 1179, 1180, 1181,




1182, 1183, 1184, 1185, 1186, 1192, 1194,




1195, 1196, 1197, 1202, 1203, 1204, 1206,




1209, 1210, 1211, 1212, 1213, 1214, 1215,




1225, 1226, 1230, 1231, 1232, 1233, 1236,




1237, 1238, 1240, 1241, 1245, 1253, 1260,




1261, 1265, 1266; 66-77 for the protein of




sequence SEQ ID No. 1189; 66-77 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
ASTTEVFK
96-103 for the proteins of SEQ No. 1202
2df


No. 1315


 


SEQ ID
ATSTEIFK
99-106 for the proteins of SEQ No. 1168, 1171,
2df


No. 1316

1216


 


SEQ ID
ATTNEIFK
97-104 for the proteins of SEQ No. 1122, 1123,
2df


No. 1317

1129, 1172, 1207, 1224, 1264; 90-97 for the




protein of sequence SEQ ID No. 1227


 


SEQ ID
ATTTAVFK
96-103 for the proteins of SEQ No. 1154
2df


No. 1318


 


SEQ ID
ATTTEIFK
97-104 for the proteins of SEQ No. 1205; 96-103
2df


No. 1319

for the protein of sequence SEQ ID No.




1157; 96-103 for the protein of sequence SEQ




ID No. 1161; 96-103 for the protein of




sequence SEQ ID No. 1169


 


SEQ ID
ATTTEVFK
96-103 for the proteins of SEQ No. 1146, 1147,
2df


No. 1320

1148, 1149, 1150, 1151, 1152, 1155, 1156,




1158, 1159, 1160, 1162, 1163, 1164, 1165,




1166, 1167, 1170, 1174, 1175, 1176, 1177,




1178, 1179, 1180, 1181, 1182, 1183, 1184,




1185, 1192, 1194, 1195, 1196, 1197, 1203,




1204, 1206, 1209, 1210, 1211, 1212, 1213,




1214, 1215, 1225, 1226, 1230, 1231, 1232,




1233, 1236, 1237, 1238, 1240, 1241, 1245,




1253, 1260, 1261, 1265, 1266; 90-97 for the




protein of sequence SEQ ID No. 1189; 90-97




for the protein of sequence SEQ ID No. 1190


 


SEQ ID
AVSDITILEQTDNYTLHGK
191-209 for the proteins of SEQ No. 1235
OXA


No. 1321


 


SEQ ID
AVSDITILEQTYNYTLHGK
191-209 for the proteins of SEQ No. 1187,
2d


No. 1322

1188


 


SEQ ID
AVVPHFEAGDWDVQGK
195-210 for the proteins of SEQ No. 1109
2de


No. 1323


 


SEQ ID
AWEHDMSLR
100-108 for the proteins of SEQ No. 1138
2d


No. 1324


 


SEQ ID
AWIGSSLQISPLEQLEFLGK
148-167 for the proteins of SEQ No. 1254,
2d


No. 1325

1255, 1257, 1258


 


SEQ ID
CAAQMAPDSTFK
63-74 for the proteins of SEQ No. 1134
2d


No. 1326


 


SEQ ID
CATQMAPDSTFK
48-59 for the proteins of SEQ No. 1119; 63-74
2d


No. 1327

for the protein of sequence SEQ ID No. 1118


 


SEQ ID
CTIIADAITGNTLYETGECAR
32-52 for the proteins of SEQ No. 1107
2d


No. 1328


 


SEQ ID
DAFLK
251-255 for the proteins of SEQ No. 1256
2d


No. 1329


 


SEQ ID
DDFILHGK
189-196 for the proteins of SEQ No. 1135
2d


No. 1330


 


SEQ ID
DDQEVLPYGGK
92-102 for the proteins of SEQ No. 1137
2df


No. 1331


 


SEQ ID
DDVLK
87-91 for the proteins of SEQ No. 1228
2df


No. 1332


 


SEQ ID
DEFHVFR
90-96 for the proteins of SEQ No. 1113, 1121
2d


No. 1333


 


SEQ ID
DEFQIFR
90-96 for the proteins of SEQ No. 1108, 1125,
OXA


No. 1334

1128, 1133, 1173, 1201, 1239, 1246; 79-85 for




the protein of sequence SEQ ID No. 1120


 


SEQ ID
DEFQVFR
90-96 for the proteins of SEQ No. 1114, 1127,
2d


No. 1335

1130, 1131, 1242, 1249


 


SEQ ID
DELVR
260-264 for the proteins of SEQ No. 1191
2d


No. 1336


 


SEQ ID
DETSR
112-116 for the proteins of SEQ No. 1139
2df


No. 1337


 


SEQ ID
DFDYGNQDFSGDK
141-153 for the proteins of SEQ No. 1118,
2d


No. 1338

1134; 126-138 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
DFTLGEAMQASTVPVYQEL
120-140 for the proteins of SEQ No. 1168,
2df


No. 1339
AR
1171, 1216


 


SEQ ID
DGNITSVAINIDMLSEADAPK
250-270 for the proteins of SEQ No. 1140
2df


No. 1340


 


SEQ ID
DHDLITAMK
108-116 for the proteins of SEQ No. 1142,
2df


No. 1341

1243


 


SEQ ID
DIAAWNR
101-107 for the proteins of SEQ No. 1142,
2df


No. 1342

1243


 


SEQ ID
DIGEDK
131-136 for the proteins of SEQ No. 1131
2d


No. 1343


 


SEQ ID
DILYIQELAGGWK
180-192 for the proteins of SEQ No. 1252
2de


No. 1344


 


SEQ ID
DITILEK
181-187 for the proteins of SEQ No. 1135
2d


No. 1345


 


SEQ ID
DLLSAK
166-171 for the proteins of SEQ No. 1256
2d


No. 1346


 


SEQ ID
DLMITEAGR
195-203 for the proteins of SEQ No. 1127,
2d


No. 1347

1130, 1131


 


SEQ ID
DLMIVEAGR
195-203 for the proteins of SEQ No. 1108,
OXA


No. 1348

1114, 1125, 1128, 1133, 1173, 1201, 1239,




1246, 1249; 184-192 for the protein of




sequence SEQ ID No. 1120


 


SEQ ID
DLMIVEAK
195-202 for the proteins of SEQ No. 1113,
2d


No. 1349

1121


 


SEQ ID
DLPLR
243-247 for the proteins of SEQ No. 1228
2df


No. 1350


 


SEQ ID
DLSGNPGK
131-138 for the proteins of SEQ No. 1105
2d


No. 1351


 


SEQ ID
DLSLR
105-109 for the proteins of SEQ No. 1115,
OXA


No. 1352

1116, 1117, 1126, 1141, 1200, 1229, 1262;




106-110 for the protein of sequence SEQ ID




No. 1248


 


SEQ ID
DLTLR
105-109 for the proteins of SEQ No. 1110,
OXA


No. 1353

1193, 1250, 1259, 1263; 96-100 for the protein




of sequence SEQ ID No. 1106; 96-100 for the




protein of sequence SEQ ID No. 1111; 96-100




for the protein of sequence SEQ ID No. 1112


 


SEQ ID
DMTLGDAIK
117-125 for the proteins of SEQ No. 1226,
2df


No. 1354

1266


 


SEQ ID
DMTLGDAMALSAVPVYQE
118-138 for the proteins of SEQ No. 1205
2df


No. 1355
LAR


 


SEQ ID
DMTLGDAMK
117-125 for the proteins of SEQ No. 1147,
2df


No. 1356

1148, 1149, 1152, 1153, 1156, 1157, 1158,




1159, 1161, 1162, 1165, 1166, 1167, 1169,




1170, 1175, 1176, 1178, 1179, 1181, 1183,




1184, 1185, 1186, 1194, 1195, 1196, 1197,




1202, 1209, 1210, 1211, 1212, 1213, 1214,




1215, 1225, 1230, 1231, 1232, 1236, 1237,




1238, 1240, 1241, 1245, 1253, 1260, 1265


 


SEQ ID
DMTLGEAMALSAVPVYQD
118-138 for the proteins of SEQ No. 1224
2df


No. 1357
LAR


 


SEQ ID
DMTLGEAMALSAVPVYQE
118-138 for the proteins of SEQ No. 1122,
2df


No. 1358
LAR
1123, 1129, 1172, 1207, 1264


 


SEQ ID
DMTLGEAMK
116-124 for the proteins of SEQ No. 1124,
2df


No. 1359

1132, 1145, 1198, 1199, 1217, 1218, 1219,




1220, 1221, 1222, 1223, 1244, 1251


 


SEQ ID
DMTLGQAMQASAVPVYQE
111-131 for the proteins of SEQ No. 1227
2df


No. 1360
LAR


 


SEQ ID
DNNGK
214-218 for the proteins of SEQ No. 1107
2d


No. 1361


 


SEQ ID
DQDLR
110-114 for the proteins of SEQ No. 1108,
2d


No. 1362

1114, 1125, 1127, 1128, 1130, 1131, 1133,




1173, 1201, 1239, 1242, 1246, 1249; 99-103




for the protein of sequence SEQ ID No. 1120


 


SEQ ID
DQQIGWFVGWASK
213-225 for the proteins of SEQ No. 1105
2d


No. 1363


 


SEQ ID
DQQIGWFVGWASKPGK
213-228 for the proteins of SEQ No. 1105
2d


No. 1364


 


SEQ ID
DQQVQVYGNDLNR
53-65 for the proteins of SEQ No. 1227
2df


No. 1365


 


SEQ ID
DQSFR
132-136 for the proteins of SEQ No. 1139
2df


No. 1366


 


SEQ ID
DQTLESAFK
105-113 for the proteins of SEQ No. 1228
2df


No. 1367


 


SEQ ID
DSCVWYSQVLTQQLGMTR
98-115 for the proteins of SEQ No. 1252
2de


No. 1368


 


SEQ ID
DSIVWYSQELTR
113-124 for the proteins of SEQ No. 1109
2de


No. 1369


 


SEQ ID
DSIVWYSQQLTR
102-113 for the proteins of SEQ No. 1256
2d


No. 1370


 


SEQ ID
DSNLR
109-113 for the proteins of SEQ No. 1187,
2d


No. 1371

1188, 1235; 96-100 for the protein of sequence




SEQ ID No. 1135; 108-112 for the protein of




sequence SEQ ID No. 1144


 


SEQ ID
DSYIAWGGEAWK
81-92 for the proteins of SEQ No. 1254, 1255,
2d


No. 1372

1257, 1258


 


SEQ ID
DTLNPEWPYK
67-76 for the proteins of SEQ No. 1252
2de


No. 1373


 


SEQ ID
DVDEVFYK
88-95 for the proteins of SEQ No. 1144, 1187,
2d


No. 1374

1188, 1235


 


SEQ ID
DVSGDPGK
144-151 for the proteins of SEQ No. 1109
2de


No. 1375


 


SEQ ID
DWILR
204-208 for the proteins of SEQ No. 1113,
2d


No. 1376

1121


 


SEQ ID
DWPAMAGAWR
265-274 for the proteins of SEQ No. 1191
2d


No. 1377


 


SEQ ID
EAFLR
256-260 for the proteins of SEQ No. 1254,
2d


No. 1378

1255, 1257, 1258


 


SEQ ID
EAIAR
250-254 for the proteins of SEQ No. 1113,
2d


No. 1379

1121, 1127, 1130, 1131, 1133, 1242


 


SEQ ID
EAIVR
250-254 for the proteins of SEQ No. 1108,
OXA


No. 1380

1114, 1125, 1128, 1173, 1201, 1239, 1246,




1249; 239-243 for the protein of sequence SEQ




ID No. 1120


 


SEQ ID
EAIVTEATPEYIVHSK
190-205 for the proteins of SEQ No. 1247,
OXA


No. 1381

1263


 


SEQ ID
EALVTEAAPEYLVHSK
190-205 for the proteins of SEQ No. 1110,
OXA


No. 1382

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1229, 1250, 1259, 1262; 181-196 for the




protein of sequence SEQ ID No. 1106; 181-196




for the protein of sequence SEQ ID No. 1111;




181-196 for the protein of sequence SEQ ID




No. 1112


 


SEQ ID
EALVTEAPEYLVHSK
191-205 for the proteins of SEQ No. 1248
2d


No. 1383


 


SEQ ID
EEIVR
240-244 for the proteins of SEQ No. 1135
2d


No. 1384


 


SEQ ID
EEVLAALPAQLK
251-262 for the proteins of SEQ No. 1105
2d


No. 1385


 


SEQ ID
EFNGSK
209-214 for the proteins of SEQ No. 1205
2df


No. 1386


 


SEQ ID
EFSAEAVNGVFVLCK
31-45 for the proteins of SEQ No. 1110, 1115,
OXA


No. 1387

1116, 1117, 1126, 1141, 1193, 1200, 1229,




1248, 1250, 1259, 1262; 22-36 for the protein




of sequence SEQ ID No. 1106; 22-36 for the




protein of sequence SEQ ID No. 1111; 22-36




for the protein of sequence SEQ ID No. 1112


 


SEQ ID
EFSSESVHGVFVLCK
31-45 for the proteins of SEQ No. 1247, 1263
OXA


No. 1388


 


SEQ ID
EGDMAK
248-253 for the proteins of SEQ No. 1137
2df


No. 1389


 


SEQ ID
EGMSGSIR
254-261 for the proteins of SEQ No. 1122,
2df


No. 1390

1129, 1172, 1207, 1264


 


SEQ ID
EGMTGSIR
254-261 for the proteins of SEQ No. 1123
2df


No. 1391


 


SEQ ID
EGSCDK
54-59 for the proteins of SEQ No. 1109
2de


No. 1392


 


SEQ ID
EIAVWNR
125-131 for the proteins of SEQ No. 1139
2df


No. 1393


 


SEQ ID
EIAYK
262-266 for the proteins of SEQ No. 1238
2df


No. 1394


 


SEQ ID
EIFER
20-24 for the proteins of SEQ No. 1135
2d


No. 1395


 


SEQ ID
EIFYHYR
79-85 for the proteins of SEQ No. 1143
2d


No. 1396


 


SEQ ID
EIGDDK
131-136 for the proteins of SEQ No. 1108,
OXA


No. 1397

1125, 1128, 1173, 1201, 1239, 1246; 120-125




for the protein of sequence SEQ ID No. 1120


 


SEQ ID
EIGDGK
131-136 for the proteins of SEQ No. 1133
2d


No. 1398


 


SEQ ID
EIGEDK
131-136 for the proteins of SEQ No. 1114,
2d


No. 1399

1130, 1249


 


SEQ ID
EIGEDNAR
131-138 for the proteins of SEQ No. 1242
OXA


No. 1400


 


SEQ ID
EIGENK
131-136 for the proteins of SEQ No. 1113,
2d


No. 1401

1121


 


SEQ ID
EIGPK
153-157 for the proteins of SEQ No. 1139
2df


No. 1402


 


SEQ ID
EIGSEIDK
136-143 for the proteins of SEQ No. 1135
2d


No. 1403


 


SEQ ID
EITYK
262-266 for the proteins of SEQ No. 1147,
2df


No. 1404

1148, 1149, 1150, 1151, 1152, 1153, 1154,




1155, 1156, 1157, 1158, 1159, 1160, 1161,




1162, 1163, 1164, 1165, 1166, 1167, 1169,




1170, 1174, 1175, 1176, 1177, 1178, 1179,




1180, 1181, 1182, 1183, 1184, 1185, 1186,




1192, 1194, 1195, 1196, 1202, 1203, 1204,




1206, 1209, 1210, 1211, 1212, 1213, 1214,




1215, 1225, 1226, 1230, 1231, 1232, 1233,




1236, 1237, 1240, 1241, 1245, 1253, 1260,




1261, 1265, 1266; 263-267 for the protein of




sequence SEQ ID No. 1122; 263-267 for the




protein of sequence SEQ ID No. 1123; 263-267




for the protein of sequence SEQ ID No. 1129;




263-267 for the protein of sequence SEQ ID




No. 1172; 256-260 for the protein of sequence




SEQ ID No. 1189; 256-260 for the protein of




sequence SEQ ID No. 1190; 263-267 for the




protein of sequence SEQ ID No. 1205; 263-267




for the protein of sequence SEQ ID No. 1207;




263-267 for the protein of sequence SEQ ID




No. 1224; 263-267 for the protein of sequence




SEQ ID No. 1264


 


SEQ ID
EITYR
262-266 for the proteins of SEQ No. 1146
2df


No. 1405


 


SEQ ID
EMIYLK
181-186 for the proteins of SEQ No. 1143
2d


No. 1406


 


SEQ ID
EMLYVER
205-211 for the proteins of SEQ No. 1168,
2df


No. 1407

1171, 1216


 


SEQ ID
EMTYK
262-266 for the proteins of SEQ No. 1197
2df


No. 1408


 


SEQ ID
ENIEK
138-142 for the proteins of SEQ No. 1187,
2d


No. 1409

1188, 1235; 137-141 for the protein of




sequence SEQ ID No. 1144


 


SEQ ID
ENQLIVK
183-189 for the proteins of SEQ No. 1110,
OXA


No. 1410

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1229, 1250, 1259, 1262; 174-180 for the




protein of sequence SEQ ID No. 1106; 174-180




for the protein of sequence SEQ ID No. 1111;




174-180 for the protein of sequence SEQ ID




No. 1112; 184-190 for the protein of sequence




SEQ ID No. 1248


 


SEQ ID
EQAILLFR
156-163 for the proteins of SEQ No. 1143
2d


No. 1411


 


SEQ ID
EQIQFLLR
165-172 for the proteins of SEQ No. 1107
2d


No. 1412


 


SEQ ID
EQLAPDPQVQQQVK
182-195 for the proteins of SEQ No. 1227
2df


No. 1413


 


SEQ ID
EQVDFVQR
189-196 for the proteins of SEQ No. 1140
2df


No. 1414


 


SEQ ID
ETEVYFFAFNMDIDNESK
229-246 for the proteins of SEQ No. 1110,
OXA


No. 1415

1193, 1250, 1259; 220-237 for the protein of




sequence SEQ ID No. 1106; 220-237 for the




protein of sequence SEQ ID No. 1111; 220-237




for the protein of sequence SEQ ID No. 1112


 


SEQ ID
ETTTPR
90-95 for the proteins of SEQ No. 1105
2d


No. 1416


 


SEQ ID
EVGEIR
126-131 for the proteins of SEQ No. 1247
2d


No. 1417


 


SEQ ID
EVGEVR
126-131 for the proteins of SEQ No. 1110,
OXA


No. 1418

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1229, 1250, 1259, 1262; 117-122 for the




protein of sequence SEQ ID No. 1106; 117-122




for the protein of sequence SEQ ID No. 1111;




117-122 for the protein of sequence SEQ ID




No. 1112; 127-132 for the protein of sequence




SEQ ID No. 1248


 


SEQ ID
EVNGSK
209-214 for the proteins of SEQ No. 1122,
2df


No. 1419

1123, 1129, 1172, 1207, 1224, 1264


 


SEQ ID
EWQENK
24-29 for the proteins of SEQ No. 1136, 1208,
2df


No. 1420

1234, 1243


 


SEQ ID
EYELYLNVWK
78-87 for the proteins of SEQ No. 1252
2de


No. 1421


 


SEQ ID
EYVPASTFK
62-70 for the proteins of SEQ No. 1110, 1115,
OXA


No. 1422

1116, 1117, 1126, 1141, 1193, 1200, 1229,




1250, 1262; 53-61 for the protein of sequence




SEQ ID No. 1106; 53-61 for the protein of




sequence SEQ ID No. 1111; 53-61 for the




protein of sequence SEQ ID No. 1112; 63-71




for the protein of sequence SEQ ID No. 1248


 


SEQ ID
EYLPVSTFK
62-70 for the proteins of SEQ No. 1259
2de


No. 1423


 


SEQ ID
EYNTSGTFVFYDGK
27-40 for the proteins of SEQ No. 1143
2d


No. 1424


 


SEQ ID
EYVPASTFK
75-83 for the proteins of SEQ No. 1146, 1147,
2df


No. 1425

1148, 1149, 1150, 1151, 1152, 1153, 1154,




1155, 1156, 1157, 1158, 1159, 1160, 1161,




1162, 1163, 1164, 1165, 1166, 1167, 1169,




1170, 1174, 1175, 1176, 1177, 1178, 1179,




1180, 1181, 1182, 1183, 1184, 1185, 1186,




1192, 1194, 1195, 1196, 1197, 1202, 1203,




1204, 1206, 1209, 1210, 1211, 1212, 1213,




1214, 1215, 1225, 1226, 1230, 1231, 1232,




1233, 1236, 1237, 1238, 1240, 1241, 1245,




1253, 1260, 1261, 1265, 1266; 76-84 for the




protein of sequence SEQ ID No. 1122; 76-84




for the protein of sequence SEQ ID No. 1123;




74-82 for the protein of sequence SEQ ID No.




1124; 76-84 for the protein of sequence SEQ




ID No. 1129; 74-82 for the protein of sequence




SEQ ID No. 1132; 74-82 for the protein of




sequence SEQ ID No. 1145; 76-84 for the




protein of sequence SEQ ID No. 1172; 69-77




for the protein of sequence SEQ ID No. 1189;




69-77 for the protein of sequence SEQ ID No.




1190; 74-82 for the protein of sequence SEQ




ID No. 1198; 74-82 for the protein of sequence




SEQ ID No. 1199; 76-84 for the protein of




sequence SEQ ID No. 1205; 76-84 for the




protein of sequence SEQ ID No. 1207; 74-82




for the protein of sequence SEQ ID No. 1217;




74-82 for the protein of sequence SEQ ID No.




1218; 74-82 for the protein of sequence SEQ




ID No. 1219; 74-82 for the protein of sequence




SEQ ID No. 1220; 74-82 for the protein of




sequence SEQ ID No. 1221; 74-82 for the




protein of sequence SEQ ID No. 1222; 74-82




for the protein of sequence SEQ ID No. 1223;




76-84 for the protein of sequence SEQ ID No.




1224; 69-77 for the protein of sequence SEQ




ID No. 1227; 74-82 for the protein of sequence




SEQ ID No. 1244; 74-82 for the protein of




sequence SEQ ID No. 1251; 76-84 for the




protein of sequence SEQ ID No. 1264


 


SEQ ID
FAAYVAGFGYGNGDISGEP
120-140 for the proteins of SEQ No. 1256
2d


No. 1426
GK


 


SEQ ID
FAPESTFK
45-52 for the proteins of SEQ No. 1252
2de


No. 1427


 


SEQ ID
FAQYAK
121-126 for the proteins of SEQ No. 1254,
2d


No. 1428

1255, 1257, 1258


 


SEQ ID
FDYGNK
138-143 for the proteins of SEQ No. 1109
2de


No. 1429


 


SEQ ID
FDYGNR
146-151 for the proteins of SEQ No. 1137;
2d


No. 1430

125-130 for the protein of sequence SEQ ID




No. 1105


 


SEQ ID
FEDLYK
232-237 for the proteins of SEQ No. 1143
2d


No. 1431


 


SEQ ID
FEDTFHISNQK
27-37 for the proteins of SEQ No. 1224
2df


No. 1432


 


SEQ ID
FEDTFHTSNQQHEK
27-40 for the proteins of SEQ No. 1205
2df


No. 1433


 


SEQ ID
FEYGNQDVSGDSGK
133-146 for the proteins of SEQ No. 1107
2d


No. 1434


 


SEQ ID
FFSDFQAK
34-41 for the proteins of SEQ No. 1133
2d


No. 1435


 


SEQ ID
FFSDLQAEGAIVIADER
34-50 for the proteins of SEQ No. 1131, 1242
2d


No. 1436


 


SEQ ID
FFSDLR
34-39 for the proteins of SEQ No. 1127, 1130
OXA


No. 1437


 


SEQ ID
FFSEFQAK
34-41 for the proteins of SEQ No. 1108, 1114,
OXA


No. 1438

1125, 1128, 1173, 1201, 1239, 1246, 1249; 23-30




for the protein of sequence SEQ ID No.




1120


 


SEQ ID
FGLEGQLR
153-160 for the proteins of SEQ No. 1117
2de


No. 1439


 


SEQ ID
FILPIFSISILVSLSACSSIK
4-24 for the proteins of SEQ No. 1122, 1123,
2df


No. 1440

1129, 1172, 1207, 1264


 


SEQ ID
FLALLFSAVVLVSLGHAQDK
5-24 for the proteins of SEQ No. 1121
2d


No. 1441


 


SEQ ID
FLALLFSAVVLVSLGHAQEK
5-24 for the proteins of SEQ No. 1113
2d


No. 1442


 


SEQ ID
FLESLYLNNLPASK
169-182 for the proteins of SEQ No. 1247,
OXA


No. 1443

1263


 


SEQ ID
FLLEGQLR
153-160 for the proteins of SEQ No. 1200
2de


No. 1444


 


SEQ ID
FQQYVDR
118-124 for the proteins of SEQ No. 1105
2d


No. 1445


 


SEQ ID
FSDYVQR
131-137 for the proteins of SEQ No. 1109
2de


No. 1446


 


SEQ ID
FSTASTFK
63-70 for the proteins of SEQ No. 1228
2df


No. 1447


 


SEQ ID
FSWDGK
117-122 for the proteins of SEQ No. 1139
2df


No. 1448


 


SEQ ID
FSYGNQNISGGIDK
139-152 for the proteins of SEQ No. 1110,
OXA


No. 1449

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1259, 1262; 130-143 for the protein of




sequence SEQ ID No. 1106; 130-143 for the




protein of sequence SEQ ID No. 1111; 130-143




for the protein of sequence SEQ ID No. 1112;




140-153 for the protein of sequence SEQ ID




No. 1248


 


SEQ ID
FSYGNQNISGGTDK
139-152 for the proteins of SEQ No. 1229
2de


No. 1450


 


SEQ ID
FSYGSQNISGGIDK
139-152 for the proteins of SEQ No. 1250
2de


No. 1451


 


SEQ ID
FTEYVK
126-131 for the proteins of SEQ No. 1107
2d


No. 1452


 


SEQ ID
FVAHK
173-177 for the proteins of SEQ No. 1107
2d


No. 1453


 


SEQ ID
FVPASTYK
62-69 for the proteins of SEQ No. 1138
2d


No. 1454


 


SEQ ID
FVYDLAQGQLPFK
184-196 for the proteins of SEQ No. 1168,
2df


No. 1455

1171, 1216


 


SEQ ID
FVYDLAQGQLPFKPEVQQQ
184-204 for the proteins of SEQ No. 1168,
2df


No. 1456
VK
1171, 1216


 


SEQ ID
FWLEDQLR
153-160 for the proteins of SEQ No. 1116,
2de


No. 1457

1193, 1229, 1250; 144-151 for the protein of




sequence SEQ ID No. 1106; 144-151 for the




protein of sequence SEQ ID No. 1111


 


SEQ ID
FWLEGPLK
144-151 for the proteins of SEQ No. 1135
2d


No. 1458


 


SEQ ID
FWLEGQLR
153-160 for the proteins of SEQ No. 1110,
OXA


No. 1459

1115, 1126, 1141, 1247, 1259, 1262, 1263;




144-151 for the protein of sequence SEQ ID




No. 1112; 154-161 for the protein of sequence




SEQ ID No. 1248


 


SEQ ID
FYPASSFK
53-60 for the proteins of SEQ No. 1135
2d


No. 1460


 


SEQ ID
FYPASTFK
66-73 for the proteins of SEQ No. 1144, 1187,
2d


No. 1461

1188, 1235


 


SEQ ID
GACDK
44-48 for the proteins of SEQ No. 1256
2d


No. 1462


 


SEQ ID
GAEVYFFAFNMDIDNENK
229-246 for the proteins of SEQ No. 1141,
2d


No. 1463

1248


 


SEQ ID
GAIQVSAVPVFQQIAR
110-125 for the proteins of SEQ No. 1110,
OXA


No. 1464

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1229, 1247, 1250, 1259, 1262, 1263; 101-116




for the protein of sequence SEQ ID No. 1106;




101-116 for the protein of sequence SEQ ID




No. 1112; 111-126 for the protein of sequence




SEQ ID No. 1248


 


SEQ ID
GAIQVSAVPVFQQITR
101-116 for the proteins of SEQ No. 1111
2de


No. 1465


 


SEQ ID
GDYWIDGNLEISAHEQISFLR
156-176 for the proteins of SEQ No. 1127,
OXA


No. 1466

1130


 


SEQ ID
GDYWIDGNLK
156-165 for the proteins of SEQ No. 1131
2d


No. 1467


 


SEQ ID
GELPVSEDALEMTK
181-194 for the proteins of SEQ No. 1109
2de


No. 1468


 


SEQ ID
GEQPAGPAAR
241-250 for the proteins of SEQ No. 1256;
OXA


No. 1469

252-261 for the protein of sequence SEQ ID




No. 1109


 


SEQ ID
GFAGHNQDQDLR
103-114 for the proteins of SEQ No. 1108,
OXA


No. 1470

1125, 1128, 1173, 1201, 1239, 1246; 92-103




for the protein of sequence SEQ ID No. 1120


 


SEQ ID
GIPSSVR
254-260 for the proteins of SEQ No. 1147,
2df


No. 1471

1148, 1149, 1150, 1151, 1152, 1153, 1155,




1156, 1157, 1158, 1159, 1160, 1161, 1162,




1163, 1164, 1165, 1166, 1167, 1169, 1170,




1174, 1175, 1176, 1177, 1178, 1179, 1180,




1181, 1182, 1183, 1184, 1185, 1186, 1192,




1194, 1195, 1196, 1197, 1202, 1203, 1204,




1206, 1209, 1210, 1211, 1212, 1213, 1214,




1215, 1225, 1226, 1230, 1231, 1232, 1233,




1236, 1237, 1238, 1240, 1241, 1245, 1253,




1260, 1261, 1265, 1266; 248-254 for the




protein of sequence SEQ ID No. 1189; 248-254




for the protein of sequence SEQ ID No. 1190


 


SEQ ID
GISSSVR
254-260 for the proteins of SEQ No. 1146
2df


No. 1472


 


SEQ ID
GLNGTFVVYDLK
26-37 for the proteins of SEQ No. 1135
2d


No. 1473


 


SEQ ID
GMEIWNSNHTPK
101-112 for the proteins of SEQ No. 1118,
2d


No. 1474

1134; 86-97 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
GNQTLVFAR
230-238 for the proteins of SEQ No. 1254
2d


No. 1475


 


SEQ ID
GNYWIDGNLEISAHEQISFLR
156-176 for the proteins of SEQ No. 1242
OXA


No. 1476


 


SEQ ID
GPLEISAFEEAR
164-175 for the proteins of SEQ No. 1137
2df


No. 1477


 


SEQ ID
GPLTITPIQEVK
172-183 for the proteins of SEQ No. 1168,
2df


No. 1478

1171, 1216


 


SEQ ID
GSGWFVGWIVR
219-229 for the proteins of SEQ No. 1254,
2d


No. 1479

1255, 1257, 1258


 


SEQ ID
GSLLLWDQK
66-74 for the proteins of SEQ No. 1139
2df


No. 1480


 


SEQ ID
GTEVYFFAFNMDIDNENK
229-246 for the proteins of SEQ No. 1115,
OXA


No. 1481

1116, 1117, 1126, 1200, 1229, 1262


 


SEQ ID
GTEVYFFAFNMDIDNESK
229-246 for the proteins of SEQ No. 1247,
OXA


No. 1482

1263


 


SEQ ID
GTFVLYDVQR
38-47 for the proteins of SEQ No. 1138
2d


No. 1483


 


SEQ ID
GTIVVADER
42-50 for the proteins of SEQ No. 1108, 1114,
OXA


No. 1484

1125, 1128, 1133, 1173, 1201, 1239, 1246,




1249; 31-39 for the protein of sequence SEQ




ID No. 1120


 


SEQ ID
GTIVVLDAR
63-71 for the proteins of SEQ No. 1140
2df


No. 1485


 


SEQ ID
GTIVVVDER
42-50 for the proteins of SEQ No. 1113, 1121
2d


No. 1486


 


SEQ ID
GTLPFSAR
200-207 for the proteins of SEQ No. 1140
2df


No. 1487


 


SEQ ID
GTPSSVR
254-260 for the proteins of SEQ No. 1154
2df


No. 1488


 


SEQ ID
HALSSAFVLLGCIAASAHAK
5-24 for the proteins of SEQ No. 1254, 1255,
2d


No. 1489

1257, 1258


 


SEQ ID
HIADSK
234-239 for the proteins of SEQ No. 1252
2de


No. 1490


 


SEQ ID
HNGLTHAWLASSLK
152-165 for the proteins of SEQ No. 1109
2de


No. 1491


 


SEQ ID
HNGLTQSWLMSSLTISPK
147-164 for the proteins of SEQ No. 1107
2d


No. 1492


 


SEQ ID
HNGTDGAWIISSLR
148-161 for the proteins of SEQ No. 1191
2d


No. 1493


 


SEQ ID
HTLSVFDQER
54-63 for the proteins of SEQ No. 1131
2d


No. 1494


 


SEQ ID
HVTFASFR
241-248 for the proteins of SEQ No. 1252
2de


No. 1495


 


SEQ ID
IAISLMGYDAGFLR
57-70 for the proteins of SEQ No. 1254, 1255,
2d


No. 1496

1257, 1258


 


SEQ ID
IALSLMAFDAEIIDQK
75-90 for the proteins of SEQ No. 1118, 1134;
2d


No. 1497

60-75 for the protein of sequence SEQ ID No.




1119


 


SEQ ID
IALSLMGFDSGILK
53-66 for the proteins of SEQ No. 1252
2de


No. 1498


 


SEQ ID
IANALIGLENHK
87-98 for the proteins of SEQ No. 1168, 1171,
2df


No. 1499

1216


 


SEQ ID
IAWIVGFVYLK
205-215 for the proteins of SEQ No. 1143
2d


No. 1500


 


SEQ ID
IDTFWLDNSLK
141-151 for the proteins of SEQ No. 1143
2d


No. 1501


 


SEQ ID
IDYYNLDR
41-48 for the proteins of SEQ No. 1135
2d


No. 1502


 


SEQ ID
IFNALIALDSGVIK
62-75 for the proteins of SEQ No. 1143
2d


No. 1503


 


SEQ ID
IFNSLLALDSGALDNER
95-111 for the proteins of SEQ No. 1140
2df


No. 1504


 


SEQ ID
IFNTLIGLENGIVK
61-74 for the proteins of SEQ No. 1135
2d


No. 1505


 


SEQ ID
IGLDLMQK
138-145 for the proteins of SEQ No. 1124,
2df


No. 1506

1132, 1145, 1198, 1199, 1217, 1218, 1219,




1220, 1221, 1222, 1223, 1244, 1251


 


SEQ ID
IGLEK
131-135 for the proteins of SEQ No. 1235
OXA


No. 1507


 


SEQ ID
IGLELMQQEVQR
133-144 for the proteins of SEQ No. 1227
2df


No. 1508


 


SEQ ID
IGLELMSK
139-146 for the proteins of SEQ No. 1147,
2df


No. 1509

1148, 1149, 1151, 1153, 1156, 1157, 1158,




1159, 1160, 1161, 1162, 1166, 1167, 1169,




1170, 1175, 1177, 1178, 1179, 1180, 1181,




1182, 1183, 1184, 1185, 1186, 1194, 1195,




1196, 1197, 1209, 1210, 1211, 1212, 1213,




1214, 1215, 1225, 1226, 1230, 1231, 1232,




1236, 1237, 1238, 1240, 1241, 1245, 1253,




1260, 1266


 


SEQ ID
IGLELMSNEVK
139-149 for the proteins of SEQ No. 1146,
2df


No. 1510

1150, 1152, 1154, 1155, 1163, 1164, 1165,




1174, 1176, 1192, 1202, 1203, 1204, 1206,




1233, 1261, 1265; 133-143 for the protein of




sequence SEQ ID No. 1189; 133-143 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
IGLER
126-130 for the proteins of SEQ No. 1138
2d


No. 1511


 


SEQ ID
IGLNK
130-134 for the proteins of SEQ No. 1118,
2d


No. 1512

1134; 115-119 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
IGLNLMQK
140-147 for the proteins of SEQ No. 1224
2df


No. 1513


 


SEQ ID
IGPSLMQSELQR
142-153 for the proteins of SEQ No. 1168,
2df


No. 1514

1171, 1216


 


SEQ ID
IGYGNMQIGTEVDQFWLK
154-171 for the proteins of SEQ No. 1171,
2df


No. 1515

1216


 


SEQ ID
IGYGNMQMGTEVDQFWLK
154-171 for the proteins of SEQ No. 1168
2df


No. 1516


 


SEQ ID
IINHNLPVK
167-175 for the proteins of SEQ No. 1119;
2d


No. 1517

182-190 for the protein of sequence SEQ ID




No. 1118


 


SEQ ID
IINHNLPVR
182-190 for the proteins of SEQ No. 1134
2d


No. 1518


 


SEQ ID
ILFQQGTQQACAER
41-54 for the proteins of SEQ No. 1191
2d


No. 1519


 


SEQ ID
ILNNWFK
20-26 for the proteins of SEQ No. 1143
2d


No. 1520


 


SEQ ID
ILNTLISLEEK
71-81 for the proteins of SEQ No. 1228
2df


No. 1521


 


SEQ ID
ILSLVCLSISIGACAEHSMSR
6-26 for the proteins of SEQ No. 1168, 1171,
2df


No. 1522

1216


 


SEQ ID
INESR
219-223 for the proteins of SEQ No. 1107
2d


No. 1523


 


SEQ ID
INIVK
255-259 for the proteins of SEQ No. 1187,
2d


No. 1524

1188, 1235; 254-258 for the protein of




sequence SEQ ID No. 1144


 


SEQ ID
INLYGNALSR
61-70 for the proteins of SEQ No. 1124, 1132,
2df


No. 1525

1145, 1198, 1199, 1217, 1218, 1219, 1220,




1221, 1222, 1223, 1244, 1251


 


SEQ ID
IPFSLNLEMK
244-253 for the proteins of SEQ No. 1122,
2df


No. 1526

1123, 1129, 1172, 1207, 1264


 


SEQ ID
IPHTLFALDADAVR
76-89 for the proteins of SEQ No. 1131
2d


No. 1527


 


SEQ ID
IPHTLFALDAGAAR
76-89 for the proteins of SEQ No. 1114, 1249
2d


No. 1528


 


SEQ ID
IPHTLFALDAGAVR
76-89 for the proteins of SEQ No. 1108, 1113,
OXA


No. 1529

1121, 1125, 1128, 1133, 1173, 1201, 1239,




1246; 65-78 for the protein of sequence SEQ




ID No. 1120


 


SEQ ID
IPLGK
255-259 for the proteins of SEQ No. 1137
2df


No. 1530


 


SEQ ID
IPNAIIGLETGVIK
71-84 for the proteins of SEQ No. 1110, 1116,
OXA


No. 1531

1117, 1126, 1141, 1200, 1229, 1250, 1262; 62-75




for the protein of sequence SEQ ID No.




1106; 62-75 for the protein of sequence SEQ




ID No. 1111; 72-85 for the protein of sequence




SEQ ID No. 1248


 


SEQ ID
IPNALIGLETGAIK
71-84 for the proteins of SEQ No. 1247, 1263
OXA


No. 1532


 


SEQ ID
IPNSLIAFDTGAVR
78-91 for the proteins of SEQ No. 1137
2df


No. 1533


 


SEQ ID
IPSAIIGLETGVIK
71-84 for the proteins of SEQ No. 1115, 1193,
2de


No. 1534

1259; 62-75 for the protein of sequence SEQ




ID No. 1112


 


SEQ ID
ISAFNQVK
161-168 for the proteins of SEQ No. 1247
2d


No. 1535


 


SEQ ID
ISAHEQILFLR
166-176 for the proteins of SEQ No. 1131
2d


No. 1536


 


SEQ ID
ISAMEQTR
160-167 for the proteins of SEQ No. 1138
2d


No. 1537


 


SEQ ID
ISAMEQVK
165-172 for the proteins of SEQ No. 1187,
2d


No. 1538

1235; 152-159 for the protein of sequence SEQ




ID No. 1135; 164-171 for the protein of




sequence SEQ ID No. 1144


 


SEQ ID
ISATEQVAFLR
164-174 for the proteins of SEQ No. 1142
2df


No. 1539


 


SEQ ID
ISATQQIAFLR
164-174 for the proteins of SEQ No. 1243
2df


No. 1540


 


SEQ ID
ISAVNQVEFLESLFLNK
161-177 for the proteins of SEQ No. 1115,
OXA


No. 1541

1116, 1117, 1126, 1141, 1200, 1229, 1262;




162-178 for the protein of sequence SEQ ID




No. 1248


 


SEQ ID
ISAVNQVEFLESLYLNK
161-177 for the proteins of SEQ No. 1110,
OXA


No. 1542

1193, 1250, 1259; 152-168 for the protein of




sequence SEQ ID No. 1106; 152-168 for the




protein of sequence SEQ ID No. 1111; 152-168




for the protein of sequence SEQ ID No. 1112


 


SEQ ID
ISAVNQVK
161-168 for the proteins of SEQ No. 1263
2de


No. 1543


 


SEQ ID
ISPEEQIQFLR
170-180 for the proteins of SEQ No. 1118,
2d


No. 1544

1134; 155-165 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
ISPEEQVR
166-173 for the proteins of SEQ No. 1109
2de


No. 1545


 


SEQ ID
ISPEGQVR
155-162 for the proteins of SEQ No. 1256
2d


No. 1546


 


SEQ ID
ISPLEQLAFLR
162-172 for the proteins of SEQ No. 1191
2d


No. 1547


 


SEQ ID
ITAFQQVDFLR
188-198 for the proteins of SEQ No. 1139
2df


No. 1548


 


SEQ ID
ITLFLLFLNLVFGQDK
4-19 for the proteins of SEQ No. 1143
2d


No. 1549


 


SEQ ID
ITPIQEVNFADDFANNR
174-190 for the proteins of SEQ No. 1205
2df


No. 1550


 


SEQ ID
ITPIQEVNFADDLANNR
174-190 for the proteins of SEQ No. 1224
2df


No. 1551


 


SEQ ID
ITPQQEAQFAYK
173-184 for the proteins of SEQ No. 1146,
2df


No. 1552

1147, 1148, 1149, 1150, 1151, 1152, 1153,




1154, 1155, 1156, 1157, 1158, 1159, 1160,




1161, 1162, 1164, 1165, 1166, 1167, 1169,




1170, 1174, 1175, 1176, 1177, 1178, 1179,




1180, 1181, 1182, 1183, 1184, 1185, 1186,




1192, 1194, 1195, 1196, 1197, 1202, 1203,




1204, 1206, 1209, 1210, 1211, 1212, 1213,




1214, 1215, 1225, 1226, 1230, 1231, 1232,




1233, 1236, 1237, 1238, 1240, 1241, 1245,




1253, 1260, 1261, 1265, 1266; 167-178 for the




protein of sequence SEQ ID No. 1189; 167-178




for the protein of sequence SEQ ID No. 1190


 


SEQ ID
ITPQQEAQFTYK
173-184 for the proteins of SEQ No. 1163
2df


No. 1553


 


SEQ ID
ITPVQEVNFADDLAHNR
174-190 for the proteins of SEQ No. 1122,
2df


No. 1554

1123, 1129, 1172, 1207, 1264


 


SEQ ID
IVAFALK
241-247 for the proteins of SEQ No. 1124,
2df


No. 1555

1145


 


SEQ ID
IVAFALNMEMR
241-251 for the proteins of SEQ No. 1198,
2df


No. 1556

1217, 1218, 1219, 1220, 1221, 1222, 1223,




1244, 1251; 242-252 for the protein of




sequence SEQ ID No. 1132; 242-252 for the




protein of sequence SEQ ID No. 1199


 


SEQ ID
IVESTTLADGTVVHGK
186-201 for the proteins of SEQ No. 1254,
2d


No. 1557

1255, 1257, 1258


 


SEQ ID
IYNSLIGLNEK
74-84 for the proteins of SEQ No. 1144, 1187,
2d


No. 1558

1188, 1235


 


SEQ ID
KPDIGWWVGWIER
237-249 for the proteins of SEQ No. 1140
2df


No. 1559


 


SEQ ID
LACATNNLAR
50-59 for the proteins of SEQ No. 1248
2d


No. 1560


 


SEQ ID
LAQGELPFPAPVQSTVR
172-188 for the proteins of SEQ No. 1138
2d


No. 1561


 


SEQ ID
LAQNELPYPIEIQK
177-190 for the proteins of SEQ No. 1187,
2d


No. 1562

1188, 1235


 


SEQ ID
LAQNELQYPIEIQK
176-189 for the proteins of SEQ No. 1144
2d


No. 1563


 


SEQ ID
LDFGNK
143-148 for the proteins of SEQ No. 1187,
2d


No. 1564

1188, 1235; 142-147 for the protein of




sequence SEQ ID No. 1144


 


SEQ ID
LDGSLNR
206-212 for the proteins of SEQ No. 1105
2d


No. 1565


 


SEQ ID
LEIGK
244-248 for the proteins of SEQ No. 1107
2d


No. 1566


 


SEQ ID
LEILQQALAELGLYPK
255-270 for the proteins of SEQ No. 1227
2df


No. 1567


 


SEQ ID
LENQEQVK
173-180 for the proteins of SEQ No. 1135
2d


No. 1568


 


SEQ ID
LETQEEVEK
195-203 for the proteins of SEQ No. 1122
2df


No. 1569


 


SEQ ID
LETQEEVK
195-202 for the proteins of SEQ No. 1123,
2df


No. 1570

1129, 1172, 1205, 1207, 1224, 1264


 


SEQ ID
LFAAEGVK
55-62 for the proteins of SEQ No. 1140
2df


No. 1571


 


SEQ ID
LFESAGVK
58-65 for the proteins of SEQ No. 1139
2df


No. 1572


 


SEQ ID
LFGAAGVK
30-37 for the proteins of SEQ No. 1138
2d


No. 1573


 


SEQ ID
LFPEWEK
110-116 for the proteins of SEQ No. 1146,
2df


No. 1574

1147, 1148, 1149, 1150, 1151, 1152, 1153,




1154, 1155, 1156, 1157, 1158, 1159, 1160,




1161, 1162, 1163, 1164, 1165, 1166, 1167,




1169, 1170, 1174, 1175, 1176, 1177, 1178,




1179, 1180, 1181, 1182, 1183, 1184, 1185,




1186, 1192, 1194, 1195, 1196, 1197, 1202,




1203, 1204, 1206, 1209, 1210, 1211, 1212,




1213, 1214, 1215, 1225, 1226, 1230, 1231,




1232, 1233, 1236, 1237, 1238, 1240, 1241,




1245, 1253, 1260, 1261, 1265, 1266; 104-110




for the protein of sequence SEQ ID No. 1189;




104-110 for the protein of sequence SEQ ID




No. 1190


 


SEQ ID
LGESR
126-130 for the proteins of SEQ No. 1109
2de


No. 1575


 


SEQ ID
LGVDR
121-125 for the proteins of SEQ No. 1107
2d


No. 1576


 


SEQ ID
LHVSER
181-186 for the proteins of SEQ No. 1136,
2df


No. 1577

1142, 1208, 1234, 1243


 


SEQ ID
LHYGNAK
131-137 for the proteins of SEQ No. 1143
2d


No. 1578


 


SEQ ID
LLNLLSQSK
160-168 for the proteins of SEQ No. 1135
2d


No. 1579


 


SEQ ID
LLQDER
243-248 for the proteins of SEQ No. 1191
2d


No. 1580


 


SEQ ID
LLVQDGDCGR
38-47 for the proteins of SEQ No. 1254, 1255,
2d


No. 1581

1257, 1258


 


SEQ ID
LNEVGYGNR
160-168 for the proteins of SEQ No. 1140
2df


No. 1582


 


SEQ ID
LNYGNADPSTK
144-154 for the proteins of SEQ No. 1113,
2d


No. 1583

1121


 


SEQ ID
LNYGNK
130-135 for the proteins of SEQ No. 1135
2d


No. 1584


 


SEQ ID
LPASK
178-182 for the proteins of SEQ No. 1247,
2d


No. 1585

1263; 172-176 for the protein of sequence SEQ




ID No. 1256


 


SEQ ID
LPHTLFALDADAVR
76-89 for the proteins of SEQ No. 1127, 1130
OXA


No. 1586


 


SEQ ID
LPHTLFALDAGAVR
76-89 for the proteins of SEQ No. 1242
OXA


No. 1587


 


SEQ ID
LPLAIMGFDSGILQSPK
62-78 for the proteins of SEQ No. 1107
2d


No. 1588


 


SEQ ID
LPLAIMGYDADILLDATTPR
69-88 for the proteins of SEQ No. 1109
2de


No. 1589


 


SEQ ID
LPSSLIALETGAVR
98-111 for the proteins of SEQ No. 1139
2df


No. 1590


 


SEQ ID
LPVSAQTLQYTANILK
170-185 for the proteins of SEQ No. 1105
2d


No. 1591


 


SEQ ID
LPVSER
205-210 for the proteins of SEQ No. 1139
2df


No. 1592


 


SEQ ID
LPVSPTAVDMTER
173-185 for the proteins of SEQ No. 1254,
2d


No. 1593

1255, 1257, 1258


 


SEQ ID
LSASK
178-182 for the proteins of SEQ No. 1110,
OXA


No. 1594

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1229, 1250, 1259, 1262; 169-173 for the




protein of sequence SEQ ID No. 1106; 169-173




for the protein of sequence SEQ ID No. 1111;




169-173 for the protein of sequence SEQ ID




No. 1112; 179-183 for the protein of sequence




SEQ ID No. 1248


 


SEQ ID
LSAVPIYQEVAR
121-132 for the proteins of SEQ No. 1137
2df


No. 1595


 


SEQ ID
LSAVPVYQELAR
127-138 for the proteins of SEQ No. 1122,
2df


No. 1596

1123, 1129, 1172, 1205, 1207, 1264; 125-136




for the protein of sequence SEQ ID No. 1124;




125-136 for the protein of sequence SEQ ID




No. 1132; 125-136 for the protein of sequence




SEQ ID No. 1145; 125-136 for the protein of




sequence SEQ ID No. 1198; 125-136 for the




protein of sequence SEQ ID No. 1199; 125-136




for the protein of sequence SEQ ID No. 1217;




125-136 for the protein of sequence SEQ ID




No. 1218; 125-136 for the protein of sequence




SEQ ID No. 1219; 125-136 for the protein of




sequence SEQ ID No. 1220; 125-136 for the




protein of sequence SEQ ID No. 1221; 125-136




for the protein of sequence SEQ ID No. 1222;




125-136 for the protein of sequence SEQ ID




No. 1223; 125-136 for the protein of sequence




SEQ ID No. 1244; 125-136 for the protein of




sequence SEQ ID No. 1251


 


SEQ ID
LSCTLVIDEASGDLLHR
37-53 for the proteins of SEQ No. 1109
2de


No. 1597


 


SEQ ID
LSLQHGWFIGWIEK
211-224 for the proteins of SEQ No. 1252
2de


No. 1598


 


SEQ ID
LSQNSLPFSQEAMNSVK
164-180 for the proteins of SEQ No. 1143
2d


No. 1599


 


SEQ ID
LSVNPK
168-173 for the proteins of SEQ No. 1252
2de


No. 1600


 


SEQ ID
LTQDER
239-244 for the proteins of SEQ No. 1254,
2d


No. 1601

1255, 1257, 1258


 


SEQ ID
LTVGAR
245-250 for the proteins of SEQ No. 1109
2de


No. 1602


 


SEQ ID
LYGFALNIDMPGGEADIGK
228-246 for the proteins of SEQ No. 1138
2d


No. 1603


 


SEQ ID
LYHNELPFR
178-186 for the proteins of SEQ No. 1114,
2d


No. 1604

1249


 


SEQ ID
LYHNK
176-180 for the proteins of SEQ No. 1136,
2df


No. 1605

1142, 1208, 1234, 1243


 


SEQ ID
LYQNDLPFR
178-186 for the proteins of SEQ No. 1133
2d


No. 1606


 


SEQ ID
MDDLFK
243-248 for the proteins of SEQ No. 1108,
OXA


No. 1607

1114, 1125, 1128, 1133, 1173, 1201, 1239,




1246, 1249; 232-237 for the protein of




sequence SEQ ID No. 1120


 


SEQ ID
MEDLHK
243-248 for the proteins of SEQ No. 1113,
2d


No. 1608

1121


 


SEQ ID
MLIALIGLENHK
85-96 for the proteins of SEQ No. 1264
2df


No. 1609


 


SEQ ID
MLLIEQQGDAALYAK
198-212 for the proteins of SEQ No. 1137
2df


No. 1610


 


SEQ ID
MLLIK
204-208 for the proteins of SEQ No. 1122,
2df


No. 1611

1123, 1129, 1172, 1205, 1207, 1224, 1264


 


SEQ ID
MLNALIGLEHHK
84-95 for the proteins of SEQ No. 1146, 1147,
2df


No. 1612

1148, 1149, 1150, 1151, 1152, 1153, 1154,




1155, 1156, 1157, 1158, 1159, 1160, 1161,




1162, 1163, 1164, 1166, 1167, 1169, 1170,




1174, 1175, 1176, 1177, 1178, 1179, 1180,




1181, 1182, 1183, 1184, 1185, 1186, 1192,




1194, 1195, 1196, 1197, 1202, 1203, 1204,




1206, 1209, 1210, 1211, 1212, 1213, 1214,




1215, 1225, 1226, 1230, 1231, 1232, 1233,




1236, 1237, 1238, 1240, 1245, 1253, 1260,




1261, 1265, 1266; 78-89 for the protein of




sequence SEQ ID No. 1189; 78-89 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
MLNALIGLENHK
85-96 for the proteins of SEQ No. 1122, 1123,
2df


No. 1613

1129, 1172, 1205, 1207, 1224


 


SEQ ID
MLNALIGLENQK
83-94 for the proteins of SEQ No. 1124, 1132,
2df


No. 1614

1145, 1198, 1199, 1217, 1218, 1219, 1220,




1221, 1222, 1223, 1244, 1251


 


SEQ ID
MLNALIGLEYHK
84-95 for the proteins of SEQ No. 1241
2df


No. 1615


 


SEQ ID
MLNALIGLQHGK
78-89 for the proteins of SEQ No. 1227
2df


No. 1616


 


SEQ ID
MLNALISLEHHK
84-95 for the proteins of SEQ No. 1165
2df


No. 1617


 


SEQ ID
MQAYVDAFDYGNR
139-151 for the proteins of SEQ No. 1137
2df


No. 1618


 


SEQ ID
MQEGLNK
123-129 for the proteins of SEQ No. 1135
2d


No. 1619


 


SEQ ID
MSPASTYK
87-94 for the proteins of SEQ No. 1140
2df


No. 1620


 


SEQ ID
MTAGGK
234-239 for the proteins of SEQ No. 1256
2d


No. 1621


 


SEQ ID
MVSGK
165-169 for the proteins of SEQ No. 1105
2d


No. 1622


 


SEQ ID
NEHDPVLPYR
71-80 for the proteins of SEQ No. 1254, 1255,
2d


No. 1623

1257, 1258


 


SEQ ID
NEHQIFK
86-92 for the proteins of SEQ No. 1248; 85-91
2d


No. 1624

for the protein of sequence SEQ ID No. 1141


 


SEQ ID
NEHQVFK
85-91 for the proteins of SEQ No. 1110, 1115,
OXA


No. 1625

1116, 1117, 1126, 1193, 1200, 1229, 1250,




1259, 1262; 76-82 for the protein of sequence




SEQ ID No. 1106; 76-82 for the protein of




sequence SEQ ID No. 1111; 76-82 for the




protein of sequence SEQ ID No. 1112


 


SEQ ID
NEITYK
262-267 for the proteins of SEQ No. 1122,
2df


No. 1626

1123, 1129, 1172, 1205, 1207, 1224, 1264


 


SEQ ID
NELLMK
260-265 for the proteins of SEQ No. 1124,
2df


No. 1627

1145, 1198, 1217, 1218, 1220, 1221, 1222,




1223, 1244, 1251; 261-266 for the protein of




sequence SEQ ID No. 1132; 261-266 for the




protein of sequence SEQ ID No. 1199


 


SEQ ID
NELMMK
260-265 for the proteins of SEQ No. 1219
2df


No. 1628


 


SEQ ID
NELPFR
181-186 for the proteins of SEQ No. 1108,
OXA


No. 1629

1113, 1114, 1121, 1125, 1128, 1173, 1201,




1239, 1246, 1249; 170-175 for the protein of




sequence SEQ ID No. 1120


 


SEQ ID
NFILIFIFVILISCK
5-19 for the proteins of SEQ No. 1144, 1187,
2d


No. 1630

1235


 


SEQ ID
NFILIFIFVILTSCK
5-19 for the proteins of SEQ No. 1188
2d


No. 1631


 


SEQ ID
NISSYGNNLVR
62-72 for the proteins of SEQ No. 1224
2df


No. 1632


 


SEQ ID
NISTYGNNLTR
62-72 for the proteins of SEQ No. 1205
2df


No. 1633


 


SEQ ID
NLFNEVHTTGVLVIR
43-57 for the proteins of SEQ No. 1170
2df


No. 1634


 


SEQ ID
NLSTYGNALAR
62-72 for the proteins of SEQ No. 1122, 1123,
2df


No. 1635

1129, 1172, 1207, 1264


 


SEQ ID
NMENLELFGK
187-196 for the proteins of SEQ No. 1143
2d


No. 1636


 


SEQ ID
NMLLLEENNGYK
201-212 for the proteins of SEQ No. 1198
2df


No. 1637


 


SEQ ID
NMLLLEESNGYK
201-212 for the proteins of SEQ No. 1124,
2df


No. 1638

1132, 1145, 1199, 1217, 1218, 1219, 1220,




1221, 1223, 1244, 1251


 


SEQ ID
NMLLLEK
201-207 for the proteins of SEQ No. 1222
2df


No. 1639


 


SEQ ID
NMTLGDAMK
117-125 for the proteins of SEQ No. 1146,
2df


No. 1640

1150, 1151, 1154, 1155, 1160, 1163, 1164,




1174, 1177, 1180, 1182, 1192, 1203, 1204,




1206, 1233, 1261; 111-119 for the protein of




sequence SEQ ID No. 1189; 111-119 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
NNGLTEAWLESSLK
156-169 for the proteins of SEQ No. 1118,
2d


No. 1641

1134; 141-154 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
NQLPFK
181-186 for the proteins of SEQ No. 1131
2d


No. 1642


 


SEQ ID
NQLPFQVEHQR
181-191 for the proteins of SEQ No. 1127,
OXA


No. 1643

1130, 1242


 


SEQ ID
NSAIENTIDNMYLQDLENS
191-211 for the proteins of SEQ No. 1134
2d


No. 1644
TK


 


SEQ ID
NSAIENTIENMYLQDLDNS
191-211 for the proteins of SEQ No. 1118
2d


No. 1645
TK


 


SEQ ID
NSAIENTIENMYLQDLENSTK
176-196 for the proteins of SEQ No. 1119
2d


No. 1646


 


SEQ ID
NSAVWVYELFAK
119-130 for the proteins of SEQ No. 1127,
OXA


No. 1647

1130, 1242


 


SEQ ID
NSQVPAYK
118-125 for the proteins of SEQ No. 1187,
2d


No. 1648

1188, 1235; 117-124 for the protein of




sequence SEQ ID No. 1144


 


SEQ ID
NSTVWIYELFAK
119-130 for the proteins of SEQ No. 1114,
2d


No. 1649

1249


 


SEQ ID
NSTVWVYELFAK
119-130 for the proteins of SEQ No. 1108,
OXA


No. 1650

1125, 1128, 1131, 1133, 1173, 1201, 1239,




1246; 108-119 for the protein of sequence SEQ




ID No. 1120


 


SEQ ID
NSTVWVYQLFAK
119-130 for the proteins of SEQ No. 1113,
2d


No. 1651

1121


 


SEQ ID
NTSGALVIQTDK
48-59 for the proteins of SEQ No. 1218
2df


No. 1652


 


SEQ ID
NTSGVLVIQTDK
48-59 for the proteins of SEQ No. 1124, 1132,
2df


No. 1653

1145, 1198, 1199, 1217, 1219, 1220, 1221,




1222, 1223, 1244, 1251


 


SEQ ID
NVDEMFYYYDGSK
75-87 for the proteins of SEQ No. 1135
2d


No. 1654


 


SEQ ID
NWILR
204-208 for the proteins of SEQ No. 1108,
OXA


No. 1655

1114, 1125, 1127, 1128, 1130, 1133, 1173,




1201, 1239, 1242, 1246, 1249; 193-197 for the




protein of sequence SEQ ID No. 1120


 


SEQ ID
NWNAAMDLR
125-133 for the proteins of SEQ No. 1140
2df


No. 1656


 


SEQ ID
NYVDAFHYGNQDISGDK
118-134 for the proteins of SEQ No. 1252
2de


No. 1657


 


SEQ ID
QADHAILVFDQAR
51-63 for the proteins of SEQ No. 1133
2d


No. 1658


 


SEQ ID
QAEHALLVFGQER
51-63 for the proteins of SEQ No. 1127, 1130,
OXA


No. 1659

1242


 


SEQ ID
QAITK
251-255 for the proteins of SEQ No. 1136,
2df


No. 1660

1142, 1208, 1243; 247-251 for the protein of




sequence SEQ ID No. 1234


 


SEQ ID
QAMLTEANSDYIIR
193-206 for the proteins of SEQ No. 1142
2df


No. 1661


 


SEQ ID
QEVQFVSALAR
171-181 for the proteins of SEQ No. 1227
2df


No. 1662


 


SEQ ID
QFASIK
243-248 for the proteins of SEQ No. 1105
2d


No. 1663


 


SEQ ID
QGMPGSIR
254-261 for the proteins of SEQ No. 1205
2df


No. 1664


 


SEQ ID
QGMSGSIR
254-261 for the proteins of SEQ No. 1224
2df


No. 1665


 


SEQ ID
QGQTQQSYGNDLAR
58-71 for the proteins of SEQ No. 1146, 1147,
2df


No. 1666

1148, 1149, 1150, 1151, 1152, 1153, 1154,




1155, 1156, 1157, 1158, 1159, 1160, 1161,




1162, 1163, 1164, 1165, 1166, 1167, 1169,




1170, 1174, 1175, 1176, 1177, 1178, 1179,




1180, 1181, 1182, 1183, 1184, 1185, 1186,




1194, 1195, 1196, 1197, 1202, 1203, 1204,




1206, 1209, 1210, 1211, 1212, 1213, 1214,




1215, 1225, 1226, 1230, 1231, 1232, 1233,




1236, 1237, 1238, 1240, 1241, 1245, 1253,




1260, 1261, 1265, 1266; 52-65 for the protein




of sequence SEQ ID No. 1189; 52-65 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
QIDYGNADPSTIK
143-155 for the proteins of SEQ No. 1127,
OXA


No. 1667

1130, 1242


 


SEQ ID
QIDYGNVDPSTIK
143-155 for the proteins of SEQ No. 1131
2d


No. 1668


 


SEQ ID
QIGEAR
129-134 for the proteins of SEQ No. 1136,
2df


No. 1669

1208, 1234, 1243


 


SEQ ID
QIGQAR
129-134 for the proteins of SEQ No. 1142
2df


No. 1670


 


SEQ ID
QIMLIEQTPAFTLR
190-203 for the proteins of SEQ No. 1228
2df


No. 1671


 


SEQ ID
QLGSAIDQFWLR
152-163 for the proteins of SEQ No. 1137
2df


No. 1672


 


SEQ ID
QLHDNK
199-204 for the proteins of SEQ No. 1139
2df


No. 1673


 


SEQ ID
QLIFVHTVVQK
229-239 for the proteins of SEQ No. 1105
2d


No. 1674


 


SEQ ID
QLIFVHTVVQKPGK
229-242 for the proteins of SEQ No. 1105
2d


No. 1675


 


SEQ ID
QLPVK
178-182 for the proteins of SEQ No. 1191;
OXA


No. 1676

184-188 for the protein of sequence SEQ ID




No. 1137


 


SEQ ID
QLPVKPR
184-190 for the proteins of SEQ No. 1137
2df


No. 1677


 


SEQ ID
QLSLDVLDK
265-273 for the proteins of SEQ No. 1168,
2df


No. 1678

1171, 1216


 


SEQ ID
QLVYAR
237-242 for the proteins of SEQ No. 1191
2d


No. 1679


 


SEQ ID
QMMLTEASTDYIIR
217-230 for the proteins of SEQ No. 1139
2df


No. 1680


 


SEQ ID
QMSIVEATPDYVLHGK
214-229 for the proteins of SEQ No. 1140
2df


No. 1681


 


SEQ ID
QPTDPAR
99-105 for the proteins of SEQ No. 1191
2d


No. 1682


 


SEQ ID
QPTDPTR
93-99 for the proteins of SEQ No. 1254, 1255,
2d


No. 1683

1257, 1258


 


SEQ ID
QPVSAGIR
246-253 for the proteins of SEQ No. 1254,
2d


No. 1684

1255, 1257, 1258


 


SEQ ID
QQLVK
275-279 for the proteins of SEQ No. 1139
2df


No. 1685


 


SEQ ID
QTLVFAR
232-238 for the proteins of SEQ No. 1254,
2d


No. 1686

1255, 1257, 1258


 


SEQ ID
QVGAEK
126-131 for the proteins of SEQ No. 1228
2df


No. 1687


 


SEQ ID
QVVFAR
238-243 for the proteins of SEQ No. 1107
2d


No. 1688


 


SEQ ID
SADEVLPYGGK
84-94 for the proteins of SEQ No. 1138
2d


No. 1689


 


SEQ ID
SADEVLPYGGKPQR
84-97 for the proteins of SEQ No. 1138
2d


No. 1690


 


SEQ ID
SCATNDLAR
50-58 for the proteins of SEQ No. 1110, 1193,
OXA


No. 1691

1250, 1259; 41-49 for the protein of sequence




SEQ ID No. 1106; 41-49 for the protein of




sequence SEQ ID No. 1111; 41-49 for the




protein of sequence SEQ ID No. 1112


 


SEQ ID
SCATNNLAR
50-58 for the proteins of SEQ No. 1115, 1116,
OXA


No. 1692

1117, 1126, 1141, 1200, 1229, 1262


 


SEQ ID
SDIPGGSK
251-258 for the proteins of SEQ No. 1107
2d


No. 1693


 


SEQ ID
SDWGK
29-33 for the proteins of SEQ No. 1133
2d


No. 1694


 


SEQ ID
SEDNFHISSQQHEK
27-40 for the proteins of SEQ No. 1122, 1123,
2df


No. 1695

1129, 1172, 1207, 1264


 


SEQ ID
SEMPASIR
252-259 for the proteins of SEQ No. 1124,
2df


No. 1696

1145, 1198, 1217, 1218, 1219, 1220, 1221,




1222, 1244, 1251; 253-260 for the protein of




sequence SEQ ID No. 1132; 253-260 for the




protein of sequence SEQ ID No. 1199


 


SEQ ID
SEMPASTR
252-259 for the proteins of SEQ No. 1223
2df


No. 1697


 


SEQ ID
SFAAHNQDQDLR
103-114 for the proteins of SEQ No. 1114,
2d


No. 1698

1249


 


SEQ ID
SFAGHNK
103-109 for the proteins of SEQ No. 1133
2d


No. 1699


 


SEQ ID
SFAGHNQDQDLR
103-114 for the proteins of SEQ No. 1127,
2d


No. 1700

1130, 1131, 1242


 


SEQ ID
SFAGHNQDQNLR
103-114 for the proteins of SEQ No. 1113,
2d


No. 1701

1121


 


SEQ ID
SFLESWAK
100-107 for the proteins of SEQ No. 1144
2d


No. 1702


 


SEQ ID
SFTAWEK
109-115 for the proteins of SEQ No. 1124,
2df


No. 1703

1132, 1145, 1199, 1217, 1218, 1219, 1220,




1221, 1222, 1223, 1244, 1251; 104-110 for the




protein of sequence SEQ ID No. 1227


 


SEQ ID
SFTTWEK
109-115 for the proteins of SEQ No. 1198
2df


No. 1704


 


SEQ ID
SGSGWLR
207-213 for the proteins of SEQ No. 1107
2d


No. 1705


 


SEQ ID
SGWGMAVDPQVGWYVGF
221-240 for the proteins of SEQ No. 1168,
2df


No. 1706
VEK
1171, 1216


 


SEQ ID
SGWGMDVSPQVGWLTGW
219-238 for the proteins of SEQ No. 1224
2df


No. 1707
VEK


 


SEQ ID
SGWGMDVTPQVGWLTGW
219-238 for the proteins of SEQ No. 1205
2df


No. 1708
VEK


 


SEQ ID
SIHPASTFK
69-77 for the proteins of SEQ No. 1137
2df


No. 1709


 


SEQ ID
SIPTK
252-256 for the proteins of SEQ No. 1110,
OXA


No. 1710

1115, 1116, 1117, 1126, 1141, 1193, 1200,




1229, 1248, 1250, 1259, 1262, 1263; 243-247




for the protein of sequence SEQ ID No. 1106;




243-247 for the protein of sequence SEQ ID




No. 1111; 243-247 for the protein of sequence




SEQ ID No. 1112


 


SEQ ID
SISTK
252-256 for the proteins of SEQ No. 1247
2d


No. 1711


 


SEQ ID
SLGLSNNLSR
76-85 for the proteins of SEQ No. 1139
2df


No. 1712


 


SEQ ID
SLSMSGK
4-10 for the proteins of SEQ No. 1109
2de


No. 1713


 


SEQ ID
SMLFIEEK
202-209 for the proteins of SEQ No. 1146,
2df


No. 1714

1147, 1148, 1149, 1150, 1151, 1152, 1153,




1154, 1155, 1156, 1157, 1158, 1159, 1160,




1161, 1162, 1163, 1164, 1165, 1166, 1167,




1169, 1174, 1175, 1176, 1177, 1178, 1179,




1180, 1182, 1183, 1184, 1185, 1186, 1192,




1194, 1195, 1196, 1197, 1202, 1203, 1204,




1209, 1210, 1211, 1212, 1213, 1214, 1215,




1225, 1226, 1230, 1231, 1232, 1233, 1236,




1237, 1238, 1240, 1241, 1245, 1253, 1260,




1261, 1265, 1266; 196-203 for the protein of




sequence SEQ ID No. 1189; 196-203 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
SNGEK
239-243 for the proteins of SEQ No. 1205,
2df


No. 1715

1224


 


SEQ ID
SNGLTHSWLGSSLK
141-154 for the proteins of SEQ No. 1256
2d


No. 1716


 


SEQ ID
SNGYK
208-212 for the proteins of SEQ No. 1124,
2df


No. 1717

1132, 1145, 1199, 1217, 1218, 1219, 1220,




1221, 1222, 1223, 1244, 1251


 


SEQ ID
SPTWELK
79-85 for the proteins of SEQ No. 1107
2d


No. 1718


 


SEQ ID
SPTWELKPEYNPSPR
79-93 for the proteins of SEQ No. 1107
2d


No. 1719


 


SEQ ID
SQDIVR
208-213 for the proteins of SEQ No. 1140
2df


No. 1720


 


SEQ ID
SQQKPTDPTIWLK
100-112 for the proteins of SEQ No. 1109
2de


No. 1721


 


SEQ ID
SQVGWLTGWVEQPDGK
225-240 for the proteins of SEQ No. 1244
2df


No. 1722


 


SEQ ID
SSSNSCTTNNAAR
46-58 for the proteins of SEQ No. 1247
2d


No. 1723


 


SEQ ID
SSSNSCTTNNATR
46-58 for the proteins of SEQ No. 1263
2de


No. 1724


 


SEQ ID
SVYGELR
139-145 for the proteins of SEQ No. 1228
2df


No. 1725


 


SEQ ID
SWILR
204-208 for the proteins of SEQ No. 1131
2d


No. 1726


 


SEQ ID
SYFDEAQTQGVIIIK
44-58 for the proteins of SEQ No. 1122, 1123,
2df


No. 1727

1129, 1172, 1205, 1207, 1224, 1264


 


SEQ ID
SYLEK
139-143 for the proteins of SEQ No. 1113,
2d


No. 1728

1121


 


SEQ ID
SYPMWEK
111-117 for the proteins of SEQ No. 1205,
2df


No. 1729

1224


 


SEQ ID
TAYIPASTFK
61-70 for the proteins of SEQ No. 1247, 1263;
2df


No. 1730

77-86 for the protein of sequence SEQ ID No.




1168; 77-86 for the protein of sequence SEQ




ID No. 1171; 77-86 for the protein of sequence




SEQ ID No. 1216


 


SEQ ID
TDDLFK
243-248 for the proteins of SEQ No. 1127,
2d


No. 1731

1130, 1131, 1242


 


SEQ ID
TDINEIFK
95-102 for the proteins of SEQ No. 1132, 1145,
2df


No. 1732

1198, 1199, 1217, 1218, 1219, 1220, 1221,




1222, 1223, 1244, 1251


 


SEQ ID
TFIHNDPR
51-58 for the proteins of SEQ No. 1228
2df


No. 1733


 


SEQ ID
TGAGFTANR
216-224 for the proteins of SEQ No. 1118,
2d


No. 1734

1134; 201-209 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
TGFNDGQK
197-204 for the proteins of SEQ No. 1143
2d


No. 1735


 


SEQ ID
TGLADSK
210-216 for the proteins of SEQ No. 1187,
2d


No. 1736

1188; 209-215 for the protein of sequence SEQ




ID No. 1144


 


SEQ ID
TGLDLMQK
140-147 for the proteins of SEQ No. 1205
2df


No. 1737


 


SEQ ID
TGLELMQK
140-147 for the proteins of SEQ No. 1122,
2df


No. 1738

1123, 1129, 1172, 1207, 1264


 


SEQ ID
TGMGYPK
198-204 for the proteins of SEQ No. 1105
2d


No. 1739


 


SEQ ID
TGNGR
197-201 for the proteins of SEQ No. 1252
2de


No. 1740


 


SEQ ID
TGTGSFIDAR
200-209 for the proteins of SEQ No. 1256
2d


No. 1741


 


SEQ ID
TGTGSLSDAK
211-220 for the proteins of SEQ No. 1109
2de


No. 1742


 


SEQ ID
TGVATEYQPEIGWWAGWV
213-232 for the proteins of SEQ No. 1137
2df


No. 1743
ER


 


SEQ ID
TGVSYPLLADGTR
202-214 for the proteins of SEQ No. 1254,
2d


No. 1744

1255, 1257, 1258


 


SEQ ID
TGWAAMDIK
217-225 for the proteins of SEQ No. 1132,
2df


No. 1745

1199


 


SEQ ID
TGWAMDIK
217-224 for the proteins of SEQ No. 1124,
2df


No. 1746

1145, 1198, 1218, 1219, 1220, 1221, 1222,




1223, 1244, 1251


 


SEQ ID
TGWAMDVK
217-224 for the proteins of SEQ No. 1217
2df


No. 1747


 


SEQ ID
TGWATR
206-211 for the proteins of SEQ No. 1228
2df


No. 1748


 


SEQ ID
TGWCFDCTPELGWWVGW
205-223 for the proteins of SEQ No. 1138
2d


No. 1749
VK


 


SEQ ID
TGWEGR
211-216 for the proteins of SEQ No. 1108,
OXA


No. 1750

1114, 1125, 1127, 1128, 1130, 1131, 1173,




1201, 1239, 1242, 1246, 1249; 200-205 for the




protein of sequence SEQ ID No. 1120


 


SEQ ID
TGWFVDK
230-236 for the proteins of SEQ No. 1140
2df


No. 1751


 


SEQ ID
TGYDTK
209-214 for the proteins of SEQ No. 1234
2df


No. 1752


 


SEQ ID
TGYGVR
233-238 for the proteins of SEQ No. 1139
2df


No. 1753


 


SEQ ID
TGYSAR
209-214 for the proteins of SEQ No. 1208
2df


No. 1754


 


SEQ ID
TGYSTR
209-214 for the proteins of SEQ No. 1136,
2df


No. 1755

1142, 1243


 


SEQ ID
THESSNWGK
25-33 for the proteins of SEQ No. 1113, 1121
2d


No. 1756


 


SEQ ID
TICTAIADAGTGK
25-37 for the proteins of SEQ No. 1254, 1255,
2d


No. 1757

1257, 1258


 


SEQ ID
TIGGAPDAYWVDDSLQISAR
169-188 for the proteins of SEQ No. 1140
2df


No. 1758


 


SEQ ID
TLPFSASSYETLR
177-189 for the proteins of SEQ No. 1228
2df


No. 1759


 


SEQ ID
TLPFSLK
189-195 for the proteins of SEQ No. 1157,
2df


No. 1760

1161, 1169


 


SEQ ID
TLPFSPK
189-195 for the proteins of SEQ No. 1147,
2df


No. 1761

1153, 1170, 1181, 1186, 1197, 1203, 1225,




1240, 1241, 1253


 


SEQ ID
TLPFSQEVQDEVQSILFIEEK
189-209 for the proteins of SEQ No. 1206
2df


No. 1762


 


SEQ ID
TLPFSQEVQDEVQSMLFIEEK
189-209 for the proteins of SEQ No. 1150,
2df


No. 1763

1192


 


SEQ ID
TLPFSQK
189-195 for the proteins of SEQ No. 1146,
2df


No. 1764

1148, 1149, 1151, 1152, 1154, 1155, 1156,




1158, 1159, 1160, 1162, 1163, 1164, 1165,




1166, 1167, 1174, 1175, 1176, 1177, 1178,




1179, 1180, 1182, 1183, 1184, 1185, 1194,




1195, 1196, 1202, 1204, 1209, 1210, 1211,




1212, 1213, 1214, 1215, 1226, 1230, 1231,




1232, 1233, 1236, 1238, 1245, 1260, 1261,




1265, 1266; 183-189 for the protein of




sequence SEQ ID No. 1189; 183-189 for the




protein of sequence SEQ ID No. 1190


 


SEQ ID
TLPSSQK
189-195 for the proteins of SEQ No. 1237
2df


No. 1765


 


SEQ ID
TLQNGWFEGFIISK
225-238 for the proteins of SEQ No. 1118,
2d


No. 1766

1134; 210-223 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
TMQEYLNK
123-130 for the proteins of SEQ No. 1143
2d


No. 1767


 


SEQ ID
TNGNSTSVYNESR
51-63 for the proteins of SEQ No. 1113, 1121
2d


No. 1768


 


SEQ ID
TQTYQAYDAAR
72-82 for the proteins of SEQ No. 1140
2df


No. 1769


 


SEQ ID
TTDPTIWEK
93-101 for the proteins of SEQ No. 1256
2d


No. 1770


 


SEQ ID
TTTTEVFK
96-103 for the proteins of SEQ No. 1153, 1186
2df


No. 1771


 


SEQ ID
TWASNDFSR
41-49 for the proteins of SEQ No. 1143
2d


No. 1772


 


SEQ ID
TWDMVQR
191-197 for the proteins of SEQ No. 1137
2df


No. 1773


 


SEQ ID
TWMQFSVVWVSQEITQK
113-129 for the proteins of SEQ No. 1118,
2d


No. 1774

1134; 98-114 for the protein of sequence SEQ




ID No. 1119


 


SEQ ID
TYPMWEK
111-117 for the proteins of SEQ No. 1122,
2df


No. 1775

1123, 1129, 1172, 1207, 1264


 


SEQ ID
TYVVDPAR
58-65 for the proteins of SEQ No. 1137
2df


No. 1776


 


SEQ ID
VAFSLNIEMK
244-253 for the proteins of SEQ No. 1205
2df


No. 1777


 


SEQ ID
VANSLIGLSTGAVR
70-83 for the proteins of SEQ No. 1138
2d


No. 1778


 


SEQ ID
VEHQR
187-191 for the proteins of SEQ No. 1108,
OXA


No. 1779

1113, 1114, 1121, 1125, 1127, 1128, 1130,




1131, 1133, 1173, 1201, 1239, 1242, 1246,




1249; 176-180 for the protein of sequence SEQ




ID No. 1120


 


SEQ ID
VELGK
248-252 for the proteins of SEQ No. 1138
2d


No. 1780


 


SEQ ID
VFDDAGVSGTFVLMDITADR
38-57 for the proteins of SEQ No. 1137
2df


No. 1781


 


SEQ ID
VFLDSWAK
88-95 for the proteins of SEQ No. 1135
2d


No. 1782


 


SEQ ID
VFLESWAK
101-108 for the proteins of SEQ No. 1187,
2d


No. 1783

1188, 1235


 


SEQ ID
VFLSSWAQDMNLSSAIK
89-105 for the proteins of SEQ No. 1143
2d


No. 1784


 


SEQ ID
VGFER
134-138 for the proteins of SEQ No. 1137
2df


No. 1785


 


SEQ ID
VILVFDQVR
55-63 for the proteins of SEQ No. 1114, 1249
2d


No. 1786


 


SEQ ID
VITFTK
228-233 for the proteins of SEQ No. 1252
2de


No. 1787


 


SEQ ID
VMAAMVR
158-164 for the proteins of SEQ No. 1139
2df


No. 1788


 


SEQ ID
VPLAVMGYDAGILVDAHN
58-77 for the proteins of SEQ No. 1256
2d


No. 1789
PR


 


SEQ ID
VQANVK
195-200 for the proteins of SEQ No. 1124,
2df


No. 1790

1132, 1145, 1198, 1199, 1217, 1218, 1219,




1220, 1221, 1222, 1223, 1244, 1251


 


SEQ ID
VQDEVK
196-201 for the proteins of SEQ No. 1202
2df


No. 1791


 


SEQ ID
VQDEVQSMLFIEEK
196-209 for the proteins of SEQ No. 1146,
2df


No. 1792

1147, 1148, 1149, 1150, 1151, 1153, 1154,




1155, 1156, 1157, 1158, 1159, 1160, 1162,




1163, 1164, 1165, 1166, 1167, 1169, 1174,




1175, 1176, 1177, 1178, 1179, 1180, 1182,




1183, 1184, 1185, 1186, 1192, 1194, 1195,




1196, 1197, 1203, 1204, 1209, 1210, 1211,




1212, 1213, 1215, 1225, 1226, 1230, 1231,




1232, 1233, 1236, 1237, 1238, 1240, 1241,




1245, 1253, 1260, 1261, 1265, 1266; 190-203




for the protein of sequence SEQ ID No. 1189;




190-203 for the protein of sequence SEQ ID




No. 1190


 


SEQ ID
VQDEVQSMLFIEEMNGNK
196-213 for the proteins of SEQ No. 1170,
2df


No. 1793

1181


 


SEQ ID
VQDGVQSMLFIEEK
196-209 for the proteins of SEQ No. 1214
2df


No. 1794


 


SEQ ID
VQHEVQSMLFIEEK
196-209 for the proteins of SEQ No. 1152
2df


No. 1795


 


SEQ ID
VSCLPCYQVVSHK
138-150 for the proteins of SEQ No. 1140
2df


No. 1796


 


SEQ ID
VSCVWCYQALAR
114-125 for the proteins of SEQ No. 1228
2df


No. 1797


 


SEQ ID
VSDVCSEVTAEGWQEVR
37-53 for the proteins of SEQ No. 1139
2df


No. 1798


 


SEQ ID
VSEVEGWQIHGK
186-197 for the proteins of SEQ No. 1105
2d


No. 1799


 


SEQ ID
VSFSLNIEMK
244-253 for the proteins of SEQ No. 1224
2df


No. 1800


 


SEQ ID
VSPCSSFK
54-61 for the proteins of SEQ No. 1107
2d


No. 1801


 


SEQ ID
VSQVPAYK
105-112 for the proteins of SEQ No. 1135
2d


No. 1802


 


SEQ ID
VVFAR
229-233 for the proteins of SEQ No. 1256;
OXA


No. 1803

239-243 for the protein of sequence SEQ ID




No. 1107; 240-244 for the protein of sequence




SEQ ID No. 1109


 


SEQ ID
WDGAK
97-101 for the proteins of SEQ No. 1113, 1121
2d


No. 1804


 


SEQ ID
WDGEK
104-108 for the proteins of SEQ No. 1151,
2df


No. 1805

1160, 1177, 1180, 1182


 


SEQ ID
WDGHIYDFPDWNR
92-104 for the proteins of SEQ No. 1228
2df


No. 1806


 


SEQ ID
WDGIK
97-101 for the proteins of SEQ No. 1114, 1249
2d


No. 1807


 


SEQ ID
WDGKPR
92-97 for the proteins of SEQ No. 1110, 1115,
OXA


No. 1808

1116, 1117, 1126, 1141, 1193, 1200, 1229,




1247, 1250, 1259, 1262, 1263; 83-88 for the




protein of sequence SEQ ID No. 1106; 83-88




for the protein of sequence SEQ ID No. 1111;




83-88 for the protein of sequence SEQ ID No.




1112; 116-121 for the protein of sequence SEQ




ID No. 1140; 107-112 for the protein of




sequence SEQ ID No. 1168; 107-112 for the




protein of sequence SEQ ID No. 1171; 107-112




for the protein of sequence SEQ ID No. 1216;




93-98 for the protein of sequence SEQ ID No.




1248


 


SEQ ID
WDGQK
104-108 for the proteins of SEQ No. 1146,
2df


No. 1809

1147, 1150, 1153, 1154, 1155, 1157, 1161,




1163, 1164, 1165, 1169, 1170, 1181, 1186,




1192, 1197, 1203, 1204, 1206, 1225, 1226,




1240, 1241, 1253, 1261, 1266; 98-102 for the




protein of sequence SEQ ID No. 1189; 98-102




for the protein of sequence SEQ ID No. 1190


 


SEQ ID
WDGQTR
95-100 for the proteins of SEQ No. 1136, 1142,
2df


No. 1810

1208, 1234, 1243


 


SEQ ID
WDGVK
97-101 for the proteins of SEQ No. 1127, 1130,
2d


No. 1811

1133, 1242


 


SEQ ID
WDGVNR
97-102 for the proteins of SEQ No. 1108, 1125,
OXA


No. 1812

1128, 1131, 1173, 1201, 1239, 1246; 86-91 for




the protein of sequence SEQ ID No. 1120


 


SEQ ID
WDYKPEFNGYK
78-88 for the proteins of SEQ No. 1256; 89-99
OXA


No. 1813

for the protein of sequence SEQ ID No. 1109


 


SEQ ID
WETYSVVWFSQQITEWLG
97-117 for the proteins of SEQ No. 1105
2d


No. 1814
MER


 


SEQ ID
WNGQK
104-108 for the proteins of SEQ No. 1152,
2df


No. 1815

1176, 1202, 1265


 


SEQ ID
YAQAK
155-159 for the proteins of SEQ No. 1140
2df


No. 1816


 


SEQ ID
YFSDFNAK
34-41 for the proteins of SEQ No. 1113, 1121
2d


No. 1817


 


SEQ ID
YGTHLDR
68-74 for the proteins of SEQ No. 1168, 1171,
2df


No. 1818

1216


 


SEQ ID
YIIHNK
54-59 for the proteins of SEQ No. 1144, 1187,
2d


No. 1819

1188, 1235


 


SEQ ID
YLDELVK
245-251 for the proteins of SEQ No. 1143
2d


No. 1820


 


SEQ ID
YLMITEAGR
195-203 for the proteins of SEQ No. 1242
OXA


No. 1821


 


SEQ ID
YLNLFSYGNANIGGGIDK
135-152 for the proteins of SEQ No. 1247,
OXA


No. 1822

1263


 


SEQ ID
YNGEK
96-100 for the proteins of SEQ No. 1187, 1188,
2d


No. 1823

1235


 


SEQ ID
YPHNPR
88-93 for the proteins of SEQ No. 1252
2de


No. 1824


 


SEQ ID
YPVVWYSQQVAHHLGAQR
103-120 for the proteins of SEQ No. 1255
2d


No. 1825


 


SEQ ID
YSNVLAFK
106-113 for the proteins of SEQ No. 1143
2d


No. 1826


 


SEQ ID
YSPASTFK
68-75 for the proteins of SEQ No. 1108, 1113,
OXA


No. 1827

1114, 1121, 1125, 1127, 1128, 1130, 1131,




1133, 1173, 1201, 1239, 1242, 1246, 1249; 57-64




for the protein of sequence SEQ ID No.




1120


 


SEQ ID
YSVVPVYQQLAR
141-152 for the proteins of SEQ No. 1139
2df


No. 1828


 


SEQ ID
YSVVWYSQLTAK
109-120 for the proteins of SEQ No. 1191
2d


No. 1829


 


SEQ ID
YSVVWYSQQVAHHLGAQR
103-120 for the proteins of SEQ No. 1254,
2d


No. 1830

1257, 1258


 


SEQ ID
YTPASTFK
55-62 for the proteins of SEQ No. 1191
2d


No. 1831


 


SEQ ID
YTSAFGYGNADVSGEPGK
130-147 for the proteins of SEQ No. 1191
2d


No. 1832


 


SEQ ID
YVFVSALTGNLGSNLTSSIK
228-247 for the proteins of SEQ No. 1119;
2d


No. 1833

243-262 for the protein of sequence SEQ ID




No. 1118


 


SEQ ID
YVFVSALTGSLGSNLTSSIK
243-262 for the proteins of SEQ No. 1134
2d


No. 1834


 


SEQ ID
YVGHDR
50-55 for the proteins of SEQ No. 1138
2d


No. 1835


 


SEQ ID
ANQAFLPASTFK
62-73 for the proteins of SEQ No. 1136, 1142,
2df


No. 2160

1208, 1234, 1243


 


SEQ ID
DEHQVFK
88-94 for the proteins of SEQ No. 1136, 1142,
2df


No. 2161

1208, 1234, 1243


 


SEQ ID
DHNLITAMK
108-116 for the proteins of SEQ No. 1136,
2df


No. 2162

1208, 1234


 


SEQ ID
DIATWNR
101-107 for the proteins of SEQ No. 1136,
2df


No. 2163

1208, 1234


 


SEQ ID
IPNSLIALDLGVVK
74-87 for the proteins of SEQ No. 1136, 1142,
2df


No. 2164

1208, 1234, 1243


 


SEQ ID
ISATEQISFLR
164-174 for the proteins of SEQ No. 1136,
2df


No. 2165

1208, 1234


 


SEQ ID
QAMLTEANGDYIIR
193-206 for the proteins of SEQ No. 1136,
2df


No. 2166

1208, 1234, 1243


 


SEQ ID
QQGFTNNLK
52-60 for the proteins of SEQ No. 1136, 1142,
2df


No. 2167

1208, 1234, 1243


 


SEQ ID
SQGVVVLWNENK
40-51 for the proteins of SEQ No. 1136, 1208,
2df


No. 2168

1234, 1243


 


SEQ ID
SWNAHFTEHK
30-39 for the proteins of SEQ No. 1136, 1208,
2df


No. 2169

1234, 1243


 


SEQ ID
VLALSAVFLVASIIGMPAVAK
3-23 for the proteins of SEQ No. 1136, 1208,
2df


No. 2170

1234, 1243


 


SEQ ID
YSVVPVYQEFAR
117-128 for the proteins of SEQ No. 1136,
2df


No. 2171

1142, 1208, 1234, 1243









In the clinical interest column, the entries 2d, 2de, 2df correspond to the functional subgroups of OXA beta-lactamases which the corresponding peptide makes it possible to detect. Therefore, the detection of a 2df peptide will indicate the presence of a carbapenemase beta-lactamase capable of hydrolysing carbapenems.
The entry 2de will indicate the presence of a beta-lactamase with an extended spectrum (ESBL) capable of hydrolysing penicillins, first-generation cephalosporins such as cephaloridine and cefalotin, and at least one antibiotic from the oxyimino-beta-lactam class such as cefotaxime, ceftazidime or monobactams such as aztreonam.
The entry OXA indicates a common peptide between at least two of the subgroups 2d, 2de and 2df. The corresponding peptide indicates the presence of an OXA beta-lactamase and the presence of a mechanism of resistance at least to penicillins and to first-generation cephalosporins.
The detection of a mechanism of resistance to ESBL (extended-spectrum beta-lactamase) cephalosporins, induced by the OXA protein, is characterised by the detection of at least one resistance-marking 2de peptide chosen from the sequences SEQ ID No. 1277, 1297, 1323, 1344, 1368, 1369, 1373, 1375, 1392, 1421, 1423, 1427, 1429, 1439, 1444, 1446, 1450, 1451, 1457, 1465, 1468, 1490, 1491, 1495, 1498, 1534, 1543, 1545, 1575, 1589, 1597, 1598, 1600, 1602, 1657, 1713, 1721, 1724, 1740, 1742, 1787, 1824, 1268, 1269, 1270, 1271, 1272, 1278, 1279, 1280, 1281, 1283, 1285, 1288, 1290, 1295, 1299, 1300, 1301, 1302, 1303, 1304, 1305, 1306, 1307, 1308, 1309, 1310, 1314, 1315, 1316, 1317, 1318, 1319, 1320, 1332, 1337, 1339, 1340, 1341, 1342, 1350, 1354, 1355, 1356, 1357, 1358, 1359, 1360, 1365, 1366, 1367, 1386, 1389, 1390, 1391, 1393, 1394, 1402, 1404, 1405, 1407, 1408, 1413, 1414, 1419, 1420, 1425, 1432, 1433, 1440, 1447, 1448, 1456, 1471, 1472, 1477, 1478, 1480, 1485, 1487, 1488, 1499, 1504, 1506, 1508, 1509, 1510, 1513, 1514, 1515, 1516, 1521, 1522, 1525, 1526, 1530, 1533, 1539, 1540, 1548, 1550, 1551, 1552, 1553, 1554, 1555, 1556, 1559, 1567, 1569, 1570, 1571, 1572, 1574, 1577, 1582, 1590, 1592, 1595, 1596, 1605, 1609, 1610, 1611, 1612, 1613, 1614, 1615, 1616, 1617, 1618, 1620, 1626, 1627, 1628, 1632, 1633, 1634, 1635, 1637, 1638, 1639, 1640, 1652, 1653, 1656, 1660, 1661, 1662, 1664, 1665, 1666, 1669, 1670, 1671, 1672, 1673, 1677, 1678, 1680, 1681, 1685, 1687, 1695, 1696, 1697, 1703, 1704, 1706, 1707, 1708, 1709, 1712, 1714, 1715, 1717, 1720, 1722, 1725, 1727, 1729, 1730, 1732, 1733, 1737, 1738, 1743, 1746, 1748, 1751, 1752, 1753, 1754, 1755, 1758, 1759, 1760, 1761, 1762, 1763, 1764, 1765, 1769, 1771, 1773, 1775, 1776, 1777, 1781, 1785, 1788, 1790, 1791, 1792, 1793, 1794, 1795, 1796, 1797, 1798, 1800, 1805, 1806, 1809, 1810, 1815, 1816, 1818, 1828, 2160, 2161, 2162, 2163, 2164, 2165, 2166, 2167, 2168, 2169, 2170, 2171.
The detection of a mechanism of resistance to carbapenems or to cephalosporins, induced by the expression of the GES protein, is characterised by the detection of at least one peptide belonging to the GES protein and to its different sequence variants SEQ ID No. 2114 to SEQ ID No. 2130.








SEQ ID No. 2114:



MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2115:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2116:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQLAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2117:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2118:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2119:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2120:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGSRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2121:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2122:


MRFIHALLLAGTAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLCDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2123:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2124:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKESEMSDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2125:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2126:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAEIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2127:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2128:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2129:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK


 


SEQ ID No. 2130:


MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQ


 


RFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTV


 


LEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPG


 


DLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVG


 


EKTGACANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS


 


TDK






said peptides being chosen, preferably, from the peptides of sequence SEQ ID No. 2131 to SEQ ID No. 2159 as defined hereafter:













Peptide





SEQ ID


Clinical


No.
Amino acid sequence
Position of the peptide in the GES protein(s)
interest







SEQ ID
AAEIGVAIVDPQGEIVAGHR
36-55 for the proteins of SEQ No. 2126
carba


No. 2131


 


SEQ ID
AAQIGVAIVDPQGEIVAGHR
36-55 for the proteins of SEQ No. 2114, 2115,
ESBL


No. 2132

2116, 2117, 2118, 2119, 2120, 2121, 2122,




2123, 2124, 2125, 2127, 2128, 2129, 2130


 


SEQ ID
AGFPK
218-222 for the proteins of SEQ No. 2114,
ESBL


No. 2133

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
DTTTPIAMAR
174-183 for the proteins of SEQ No. 2114,
ESBL


No. 2134

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
DWVVGEK
223-229 for the proteins of SEQ No. 2114,
ESBL


No. 2135

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
DYAVAVYTTAPK
250-261 for the proteins of SEQ No. 2114,
ESBL


No. 2136

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
EIGGPAAMTQYFR
136-148 for the proteins of SEQ No. 2114,
ESBL


No. 2137

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
EPEMGDNTPGDLR
161-173 for the proteins of SEQ No. 2114,
ESBL


No. 2138

2115, 2116, 2120, 2121, 2122, 2127, 2128, 2130


 


SEQ ID
EPEMNDNTPGDLR
161-173 for the proteins of SEQ No. 2117, 2123
carba


No. 2139


 


SEQ ID
EPEMSDNTPGDLR
161-173 for the proteins of SEQ No. 2118,
carba


No. 2140

2119, 2125, 2126, 2129


 


SEQ ID
ESEMSDNTPGDLR
161-173 for the proteins of SEQ No. 2124
carba


No. 2141


 


SEQ ID
FAMCSTFK
60-67 for the proteins of SEQ No. 2114, 2115,
ESBL


No. 2142

2116, 2117, 2118, 2119, 2120, 2121, 2122,




2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130


 


SEQ ID
FIHALLLAGIAHSAYASEK
3-21 for the proteins of SEQ No. 2114, 2115,
ESBL


No. 2143

2116, 2117, 2118, 2119, 2120, 2121, 2123,




2124, 2125, 2126, 2127, 2128, 2129, 2130


 


SEQ ID
FIHALLLAGTAHSAYASEK
3-21 for the proteins of SEQ No. 2122
carba


No. 2144


 


SEQ ID
FPLAALVFER
68-77 for the proteins of SEQ No. 2114, 2115,
ESBL


No. 2145

2116, 2117, 2118, 2119, 2120, 2121, 2122,




2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130


 


SEQ ID
IDSGTER
78-84 for the proteins of SEQ No. 2114, 2115,
ESBL


No. 2146

2116, 2117, 2118, 2119, 2120, 2121, 2122,




2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130


 


SEQ ID
IGDSVSR
150-156 for the proteins of SEQ No. 2114,
ESBL


No. 2147

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
LSAVER
262-267 for the proteins of SEQ No. 2114,
ESBL


No. 2148

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
LSYGPDMIVEWSPATER
89-105 for the proteins of SEQ No. 2114, 2116,
ESBL


No. 2149

2117, 2118, 2120, 2121, 2122, 2124, 2125,




2126, 2130


 


SEQ ID
LSYGPDMIVK
89-98 for the proteins of SEQ No. 2115, 2119,
carba


No. 2150

2123, 2127, 2128, 2129


 


SEQ ID
NDIGFFK
239-245 for the proteins of SEQ No. 2114,
ESBL


No. 2151

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
TDLEK
26-30 for the proteins of SEQ No. 2114, 2115,
ESBL


No. 2152

2116, 2117, 2118, 2119, 2120, 2121, 2122,




2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130


 


SEQ ID
TGACANGAR
230-238 for the proteins of SEQ No. 2130
carba


No. 2153


 


SEQ ID
TGTCANGAR
230-238 for the proteins of SEQ No. 2121,
carba


No. 2154

2125, 2127


 


SEQ ID
TGTCANGGR
230-238 for the proteins of SEQ No. 2114,
ESBL


No. 2155

2115, 2116, 2117, 2118, 2119, 2122, 2123,




2124, 2126, 2128, 2129


 


SEQ ID
TGTCANGSR
230-238 for the proteins of SEQ No. 2120
carba


No. 2156


 


SEQ ID
VLYGGALTSTSTHTIER
188-204 for the proteins of SEQ No. 2114,
ESBL


No. 2157

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
WLIGNQTGDATLR
205-217 for the proteins of SEQ No. 2114,
ESBL


No. 2158

2115, 2116, 2117, 2118, 2119, 2120, 2121,




2122, 2123, 2124, 2125, 2126, 2127, 2128,




2129, 2130


 


SEQ ID
WSPATER
99-105 for the proteins of SEQ No. 2114, 2115,
carba


No. 2159

2116, 2117, 2118, 2119, 2120, 2121, 2122,




2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130









In the clinical interest column, the ESBL and carba entries correspond to the GES beta-lactamase activities which the corresponding peptide makes it possible to detect. Therefore, the detection of a carba peptide will indicate the presence of a carbapenemase beta-lactamase capable of hydrolysing carbapenems, penicillins, first-generation cephalosporins such as cephaloridine and cefalotin, and at least one antibiotic from the oxyimino-beta-lactam class such as cefotaxime, ceftazidime or the monobactames such as aztreonam.
If no peptide referred to as carba is detected, the detection of a peptide referred to as ESBL will indicate the presence of a beta-lactamase with an extended spectrum (ESBL) capable of hydrolysing penicillins, first-generation cephalosporins such as cephaloridine and cefalotin, and at least one antibiotic from the oxyimino-beta-lactam class such as cefotaxime, ceftazidime or monobactams such as aztreonam.
The detection of a mechanism of resistance to cephalosporinases with an extended spectrum (ESBL) induced by the GES protein is thus characterised by the detection of at least one resistance-marking ESBL peptide chosen from the sequences SEQ ID No. 2131 to SEQ ID No. 2159.
Certain peptide sequences can be common to several resistance mechanisms. Therefore, the following sequences are identical:
SEQ ID No. 834 and SEQ ID No. 978
SEQ ID No. 833 and SEQ ID No. 977
SEQ ID No. 832 and SEQ ID No. 976
SEQ ID No. 831 and SEQ ID No. 975
SEQ ID No. 826 and SEQ ID No. 974
SEQ ID No. 825 and SEQ ID No. 973
SEQ ID No. 824 and SEQ ID No. 972
SEQ ID No. 823 and SEQ ID No. 971
SEQ ID No. 822 and SEQ ID No. 970
SEQ ID No. 817 and SEQ ID No. 969
SEQ ID No. 813 and SEQ ID No. 967
SEQ ID No. 802 and SEQ ID No. 964
SEQ ID No. 798 and SEQ ID No. 963
SEQ ID No. 666 and SEQ ID No. 895
SEQ ID No. 350 and SEQ ID No. 1035
SEQ ID No. 349 and SEQ ID No. 1031
SEQ ID No. 347 and SEQ ID No. 1030
SEQ ID No. 346 and SEQ ID No. 1029
SEQ ID No. 345 and SEQ ID No. 1028
SEQ ID No. 343 and SEQ ID No. 1037 and SEQ ID No. 725
SEQ ID No. 342 and SEQ ID No. 1026
SEQ ID No. 341 and SEQ ID No. 1025
SEQ ID No. 340 and SEQ ID No. 1024
SEQ ID No. 339 and SEQ ID No. 1023
SEQ ID No. 338 and SEQ ID No. 1020
SEQ ID No. 337 and SEQ ID No. 1036 and SEQ ID No. 719
SEQ ID No. 337 and SEQ ID No. 1036
SEQ ID No. 336 and SEQ ID No. 841 and SEQ ID No. 981
SEQ ID No. 323 and SEQ ID No. 840 and SEQ ID No. 980
SEQ ID No. 315 and SEQ ID No. 839 and SEQ ID No. 948 and SEQ ID No. 979
SEQ ID No. 240 and SEQ ID No. 679
SEQ ID No. 184 and SEQ ID No. 626
SEQ ID No. 182 and SEQ ID No. 625
SEQ ID No. 1034 and SEQ ID No. 1999
SEQ ID No. 1032 and SEQ ID No. 1988
SEQ ID No. 1027 and SEQ ID No. 1970
SEQ ID No. 1022 and SEQ ID No. 1952
SEQ ID No. 1021 and SEQ ID No. 1937
SEQ ID No. 1019 and SEQ ID No. 1933
SEQ ID No. 809 and SEQ ID No. 966
SEQ ID No. 1033 and SEQ ID No. 1989
In all cases, the sequences above indicate the expression of a mechanism of resistance to cephalosporins.
The method of the invention and its advantages will become apparent from the rest of the present description which presents several non-limiting examples of implementation of said method.


EXAMPLE 1
Identification of Microorganisms from a Sample by Biochemical Profile
1. Culturing of the Sample on a Culture Medium
The optimum culture media and the optimum culture conditions are different according to the species of microorganism. By default, the sample is seeded on different media:

    
    
        sheep blood Columbia agar (bioMérieux ref. 43041) for 18 to 24 h at 35° C., in an aerobic or anaerobic atmosphere;
        TSA agar (bioMérieux ref. 43011) for 18 to 24 h at 37° C.
    
    


2. Identification of the Microorganisms
The identification is performed as follows:

    
    
        1. Selection of isolated colonies
        2. While maintaining the aseptic conditions, transfer of 3.0 mL of aqueous sterile saline solution (0.45-0.50% NaCl, pH 4.5 to 7.0) into a transparent plastic (polystyrene) test tube
        3. With the aid of a stirrer or a sterile swab, transfer of a sufficient number of identical colonies into the saline solution tube prepared in step 2, and adjustment of the bacterial suspension between 0.50 and 0.63 McFarland with a calibrated DENSICHEK from VITEK®
        4. Positioning of the bacterial suspension tube and of a VITEK® identification card on a VITEK® cartridge
        5. Loading of the cartridge into the VITEK® instrument
        6. The filling, sealing, incubation and reading operations are automatic
        7. Acquisition of a biochemical profile
        8. Identification with the VITEK® system performed by comparing to the biochemical profiles of known strains
    
    


EXAMPLE 2
Preparation of a Primary Urine Sample by Microorganism Enrichment
The following protocol is performed in 16 steps (steps 5 to 12 are optional and could be omitted if the enriched sample is subsequently treated according to examples 4 and onwards):

    
    
        1. Centrifuging of 5 mL of contaminated urine, at 2000 g for 30 seconds
        2. Recovery of the supernatant
        3. Centrifuging at 15000 g for 5 minutes
        4. Elimination of the supernatant
        5. Washing of the pellet with 3 mL of distilled water by resuspension
        6. Centrifuging at 15000 g for 5 minutes
        7. Elimination of the supernatant
        8. Place the pellet in the presence of solvent (8 acetone volumes for 1 methanol volume) for 1/10 dilution
        9. Leave for 1 hour at −20° C.
        10. Centrifuging at 15000 g for 5 minutes
        11. Elimination of the supernatant
        12. Place the pellet in the presence of solvent (8 acetone volumes for 1 methanol volume) for 1/10 dilution
        13. Leave for 1 hour at −20° C.
        14. Centrifuging at 15000 g for 5 minutes
        15. Elimination of the supernatant
        16. The pellet constitutes the microorganism-enriched sample
    
    


EXAMPLE 3
Identification of Microorganisms from a Sample by MALDI-TOF
The identification is performed as follows:

    
    
        1. Transfer, with the aid of a 1 μl oese, of a portion of microorganism colony obtained according to example 1, or of an enriched sample according to example 2, and uniform deposition on a plate for MALDI-TOF mass spectrometry
        2. Covering the deposit with 1 μl of matrix. The matrix used is a saturated solution of HCCA (alpha-cyano-4-hydroxycinnamic acid) in organic solvent (50% acetonitrile and 2.5% trifluoroacetic acid)
        3. Drying at ambient temperature
        4. Introducing the plate into the mass spectrometer
        5. Acquiring a mass spectrum
        6. Comparing the obtained spectrum with the spectra contained in a knowledge base
        7. Identification of the microorganism by comparing the obtained peaks with those in the knowledge base
    
    


EXAMPLE 4
Identification of Microorganisms from a Sample by ESI-TOF
The identification is performed as follows:

    
    
        1. Sampling of a microorganism colony, obtained according to example 1, or of an enriched sample according to example 2, and suspension in 100 μl of demineralised water.
        2. Centrifuging at 3000 g for 5 minutes.
        3. Elimination of the supernatant.
        4. Resuspension in 100 μl of demineralised water.
        5. Centrifuging at 3000 g for 5 minutes.
        6. Elimination of the supernatant.
        7. Resuspension in 100 μl of an acetonitrile, demineralised water and formic acid mixture (50/50/0.1%).
        8. Filtration with a filter with a porosity of 0.45 μm.
        9. Injection into a mass spectrometer in single MS mode.
        10. Acquisition of a mass spectrum.
        11. Comparing the obtained spectrum with the spectra contained in a knowledge base.
        12. Identification of the microorganism by referring to reference spectra.
    
    


EXAMPLE 5
Obtaining Digested Proteins from Microorganisms
The following protocol is conventionally performed in 17 steps:

    
    
        1. Sampling of a microorganism colony, obtained according to example 1, or of an enriched sample according to example 2, and suspension in 10 to 100 μl of a 6M guanidine hydrochloride solution, 50 mM Tris-HCl, pH=8.0.
        2. Addition of dithiothreitol (DTT) to achieve an end concentration of 5 mM.
        3. Reduction for 20 minutes at 95° C. in a water bath.
        4. Cooling the tubes to ambient temperature
        5. Addition of iodoacetamide to obtain an end concentration of 12.5 mM.
        6. Alkylation for 40 minutes at ambient temperature and in the dark.
        7. Dilution by a factor of 6 with a 50 mM NH4HCO3 solution, pH=8.0 to obtain an end guanidine hydrochloride concentration of 1M.
        8. Addition of 1 μg of trypsin.
        9. Digestion at 37° C. for between 6 hours and one night.
        10. Addition of formic acid down to a pH below 4 to stop the reaction.
        11. The sample volume is made up to 1 mL with water/0.5% (v/v) formic acid
        12. Balancing of the Waters Oasis HLB columns with 1 ml of methanol and then 1 ml of H2O/0.1% (v/v) formic acid
        13. Deposition of the sample which runs off by gravity
        14. Washing with 1 ml of H2O/0.1% (v/v) formic acid
        15. Elution with 1 ml of a mixture of 80% methanol and 20% water/0.1% (v/v) formic acid
        16. The eluate is evaporated with a SpeedVac® SPD2010 evaporator (Thermo Electron Corporation, Waltham, Mass., United States of America) over 2 hours, in order to obtain a volume of around 100 μl.
        17. The eluate is then taken up in a water/0.5% (v/v) formic acid solution in a quantity sufficient for (QSF) 250 μl
    
    


EXAMPLE 6
Identification of a Resistance to TEM Beta-Lactams
Samples Sam10 to Sam61 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 1.










TABLE 1







Names
Species









Sam10
P. mirabilis



Sam11
E. coli



Sam12
E. aerogenes



Sam13
E. coli



Sam14
E. coli



Sam15
E. coli



Sam16
S. marcescens



Sam17
E. coli



Sam18
E. coli



Sam19
P. mirabilis



Sam20
C. freundii



Sam21
E. coli



Sam22
P. mirabilis



Sam23
E. coli



Sam24
K. pneumoniae



Sam25
E. coli



Sam26
K. oxytoca



Sam27
P. mirabilis



Sam28
E. coli



Sam29
P. mirabilis



Sam30
P. rettgeri



Sam31
P. stuartii



Sam32
S. Derby



Sam33
E. coli



Sam34
E. coli



Sam35
E. coli



Sam36
E. coli



Sam37
E. coli



Sam38
E. coli



Sam39
E. coli



Sam40
E. coli



Sam41
E. coli



Sam42
E. coli



Sam43
E. coli



Sam44
E. coli



Sam45
K. pneumoniae



Sam46
E. coli



Sam47
K. pneumoniae



Sam48
P. mirabilis



Sam49
P. mirabilis



Sam50
P. mirabilis



Sam51
P. mirabilis



Sam52
P. mirabilis



Sam53
K. pneumoniae



Sam54
P. mirabilis



Sam55
E. coli



Sam56
E. coli



Sam57
P. mirabilis



Sam58
E. aerogenes



Sam59
E. aerogenes



Sam60
E. coli



Sam61
E. coli










Samples Sam10 to Sam61 correspond to a species able to comprise a TEM resistance mechanism (Enterobacteriaceae . . . ). The following method is then performed to search for such a mechanism.
Each sample is treated according to example 5, then a volume of 50 μl of digested proteins is injected and analysed according to the following conditions:

    
    
        Dionex Ultimate 3000 chromatographic channel from the Dionex Corporation (Sunnyvale, United States of America).
        Waters BEH130 C18 Column, 2.1 mm inner diameter, 100 mm length, 3.5 μm particle size (Waters, Saint-Quentin En Yvelines, France).
        Solvent A: H2O+0.1% formic acid.
        Solvent B: ACN+0.1% formic acid.
    
    


HPLC gradient defined in Table 2 hereafter:












TABLE 2







Time (min)
Flow (μl)
Solvent A (%)
Solvent B (%)





















0
300
98
2



3
300
98
2



34
300
54.6
45.4



35
300
0
100



55
300
0
100



55.1
300
98
2



74
300
98
2










    
    
        The eluate coming from the chromatographic column is directly injected into the ionising source of the QTRAP® 5500 mass spectrometer from Applied Biosystems (Foster City, United States of America).
        The peptides coming from the digestion of the microorganism proteins are analysed by the mass spectrometer in MRM mode. Only the peptides indicated in TABLE 3 are detected. To this end, the fragment(s) of the peptides indicated in TABLE 3 is/are detected. The charge state of the precursor, and the possible existence of an oxidised methionine, are also indicated in TABLE 3.
    
    














TABLE 3





Transition

Methionine

Charge state of
Clinical


number
Peptide
oxidation
Fragment ion
the precursor
interest




















1
DAENQLGAR
no
y4 monocharged
2
TEM


 


2
DAENQLGAR
no
y6 monocharged
2
TEM


 


3
DAENQLGAR
no
y7 monocharged
2
TEM


 


4
ELTAFLHNIGDHVTR
no
y4 monocharged
2
TEM


 


5
ELTAFLHNIGDHVTR
no
y8 monocharged
2
TEM


 


6
ELTAFLHNIGDHVTR
no
y9 monocharged
2
TEM


 


7
ELTAFLHNMGDNVTR
no
y7 monocharged
2
2b


 


8
ELTAFLHNMGDNVTR
no
y8 monocharged
2
2b


 


9
ELTAFLHNMGDNVTR
no
y9 monocharged
2
2b


 


10
FPMISTFK
yes
y5 monocharged
2
2br


 


11
FPMISTFK
yes
y6 monocharged
2
2br


 


12
FPMISTFK
yes
y7 monocharged
2
2br


 


13
FPMISTFK
no
y5 monocharged
2
2br


 


14
FPMISTFK
no
y6 monocharged
2
2br


 


15
FPMISTFK
no
y7 monocharged
2
2br


 


16
GEPELNEAIPNDER
no
y12 dicharged
2
2be


 


17
GEPELNEAIPNDER
no
y5 monocharged
2
2be


 


18
GEPELNEAIPNDER
no
y7 monocharged
2
2be


 


19
GSLGIIAALGPDGKPSR
no
y10 monocharged
2
2br


 


20
GSLGIIAALGPDGKPSR
no
y8 monocharged
2
2br


 


21
GSLGIIAALGPDGKPSR
no
y9 monocharged
2
2br


 


22
IHYSQNDLVEYSPVTEK
no
y6 monocharged
3
TEM


 


23
IHYSQNDLVEYSPVTEK
no
y7 monocharged
3
TEM


 


24
IHYSQNDLVEYSPVTEK
no
y8 monocharged
3
TEM


 


25
ILESFRPEER
no
b6 monocharged
2
TEM


 


26
ILESFRPEER
no
b8 monocharged
2
TEM


 


27
ILESFRPEER
no
y7 dicharged
2
TEM


 


28
IVVIYTTGGQATMDER
yes
y7 monocharged
2
2be


 


29
IVVIYTTGGQATMDER
yes
y8 monocharged
2
2be


 


30
IVVIYTTGGQATMDER
yes
y9 monocharged
2
2be


 


31
IVVIYTTGGQATMDER
no
y6 monocharged
2
2be


 


32
IVVIYTTGGQATMDER
no
y8 monocharged
2
2be


 


33
IVVIYTTGGQATMDER
no
y9 monocharged
2
2be


 


34
LDSWEPELNEAIPNDER
no
y5 monocharged
3
2be


 


35
LDSWEPELNEAIPNDER
no
y6 monocharged
3
2be


 


36
LDSWEPELNEAIPNDER
no
y7 monocharged
3
2be


 


37
QIAEICASLIK
no
y6 monocharged
2
TEM


 


38
QIAEICASLIK
no
y7 monocharged
2
TEM


 


39
QIAEICASLIK
no
y8 monocharged
2
TEM


 


40
SGANER
no
y3 monocharged
2
TEM


 


41
SGANER
no
y4 monocharged
2
TEM


 


42
SGANER
no
y5 monocharged
2
TEM


 


43
SGGSER
no
y3 monocharged
2
2be


 


44
SGGSER
no
y4 monocharged
2
2be


 


45
SGGSER
no
y5 monocharged
2
2be


 


46
VDAGQEQLDR
no
y7 monocharged
2
TEM


 


47
VDAGQEQLDR
no
y8 monocharged
2
TEM


 


48
VDAGQEQLDR
no
y9 monocharged
2
TEM


 


49
VKPAEDK
no
y4 monocharged
2
2be


 


50
VKPAEDK
no
y5 monocharged
2
2be


 


51
VKPAEDK
no
y6 monocharged
2
2be


 


52
WEPELNEAIPIDER
no
y12 dicharged
2
2be


 


53
WEPELNEAIPIDER
no
y5 monocharged
2
2be


 


54
WEPELNEAIPIDER
no
y7 monocharged
2
2be


 


55
DTTMPAAMATK
yes
y7 monocharged
2
TEM


 


56
DTTMPAAMATK
yes
y8 monocharged
2
TEM


 


57
DTTMPAAMATK
yes
y9 monocharged
2
TEM


 


58
DTTMPAAMATK
no
y7 monocharged
2
TEM


 


59
DTTMPAAMATK
no
y8 monocharged
2
TEM


 


60
DTTMPAAMATK
no
y9 monocharged
2
TEM


 


61
ELTAFLHNMGDHVTR
no
y13 dicharged
2
TEM


 


62
ELTAFLHNMGDHVTR
no
y4 monocharged
2
TEM


 


63
ELTAFLHNMGDHVTR
no
y8 monocharged
2
TEM


 


64
EPELNEAIPNDER
no
y5 monocharged
2
TEM


 


65
EPELNEAIPNDER
no
y7 monocharged
2
TEM


 


66
EPELNEAIPNDER
no
y8 monocharged
2
TEM


 


67
FPMMSTFK
yes
y6 monocharged
2
TEM


 


68
FPMMSTFK
yes
y7 monocharged
2
TEM


 


69
FPMMSTFK
yes
y7 dicharged
2
TEM


 


70
FPMMSTFK
no
y6 monocharged
2
TEM


 


71
FPMMSTFK
no
y7 monocharged
2
TEM


 


72
FPMMSTFK
no
y7 dicharged
2
TEM


 


73
GIIAALGPDGKPSR
no
y7 monocharged
2
TEM


 


74
GIIAALGPDGKPSR
no
y8 monocharged
2
TEM


 


75
GIIAALGPDGKPSR
no
y9 monocharged
2
TEM


 


76
IDAGQEQLGR
no
y7 monocharged
2
TEM


 


77
IDAGQEQLGR
no
y8 monocharged
2
TEM


 


78
IDAGQEQLGR
no
y9 monocharged
2
TEM


 


79
IHYSQNDLVK
no
y7 monocharged
2
2be


 


80
IHYSQNDLVK
no
y8 monocharged
2
2be


 


81
IHYSQNDLVK
no
y9 dicharged
2
2be


 


82
IHYSQSDVVEYSPVTEK
no
y16 dicharged
2
TEM


 


83
IHYSQSDVVEYSPVTEK
no
y5 monocharged
2
TEM


 


84
IHYSQSDVVEYSPVTEK
no
y6 monocharged
2
TEM


 


85
IVVIYMTGGQATMDER
no
y6 monocharged
2
2be


 


86
IVVIYMTGGQATMDER
no
y8 monocharged
2
2be


 


87
IVVIYMTGGQATMDER
no
y9 monocharged
2
2be


 


88
LDCWEPELNEAIPNDER
no
y5 monocharged
3
2be


 


89
LDCWEPELNEAIPNDER
no
y6 monocharged
3
2be


 


90
LDCWEPELNEAIPNDER
no
y7 monocharged
3
2be


 


91
MSIQHFR
yes
y4 monocharged
2
TEM


 


92
MSIQHFR
yes
y5 monocharged
2
TEM


 


93
MSIQHFR
yes
y6 monocharged
2
TEM


 


94
MSIQHFR
no
y4 monocharged
2
TEM


 


95
MSIQHFR
no
y5 monocharged
2
TEM


 


96
MSIQHFR
no
y6 monocharged
2
TEM


 


97
QQLIDWMEADK
no
y5 monocharged
2
TEM


 


98
QQLIDWMEADK
no
y6 monocharged
2
TEM


 


99
QQLIDWMEADK
no
y7 monocharged
2
TEM


 


100
SGASER
no
y3 monocharged
2
2be


 


101
SGASER
no
y4 monocharged
2
2be


 


102
SGASER
no
y5 monocharged
2
2be


 


103
VALIPFLAAFCLPVFAHPETLVK
no
y11 dicharged
3
2ber


 


104
VALIPFLAAFCLPVFAHPETLVK
no
y6 monocharged
3
2ber


 


105
VALIPFLAAFCLPVFAHPETLVK
no
y8 monocharged
3
2ber


 


106
VGYIELDLNSGK
no
y7 monocharged
2
TEM


 


107
VGYIELDLNSGK
no
y8 monocharged
2
TEM


 


108
VGYIELDLNSGK
no
y9 monocharged
2
TEM


 


109
VLLCGAELSR
no
y6 monocharged
2
TEM


 


110
VLLCGAELSR
no
y7 monocharged
2
TEM


 


111
VLLCGAELSR
no
y8 monocharged
2
TEM


 


112
DAEDQLGAR
no
y5 monocharged
2
TEM


 


113
DAEDQLGAR
no
y6 monocharged
2
TEM


 


114
DAEDQLGAR
no
y7 monocharged
2
TEM


 


115
ETTTPAAMATTLR
yes
y7 monocharged
2
2be


 


116
ETTTPAAMATTLR
yes
y9 monocharged
2
2be


 


117
ETTTPAAMATTLR
yes
y9 dicharged
2
2be


 


118
ETTTPAAMATTLR
no
y7 monocharged
2
2be


 


119
ETTTPAAMATTLR
no
y9 monocharged
2
2be


 


120
ETTTPAAMATTLR
no
y9 dicharged
2
2be


 


121
FPMVSTFK
yes
y6 monocharged
2
TEM


 


122
FPMVSTFK
yes
y7 monocharged
2
TEM


 


123
FPMVSTFK
yes
y7 dicharged
2
TEM


 


124
FPMVSTFK
no
y6 monocharged
2
TEM


 


125
FPMVSTFK
no
y7 monocharged
2
TEM


 


126
FPMVSTFK
no
y7 dicharged
2
TEM


 


127
GSGGIIAALGPDGKPSR
no
y7 monocharged
2
2br


 


128
GSGGIIAALGPDGKPSR
no
y8 monocharged
2
2br


 


129
GSGGIIAALGPDGKPSR
no
y9 monocharged
2
2br


 


130
HLTDGMTVR
yes
y5 monocharged
2
TEM


 


131
HLTDGMTVR
yes
y7 monocharged
2
TEM


 


132
HLTDGMTVR
yes
y8 monocharged
2
TEM


 


133
HLTDGMTVR
no
y4 monocharged
2
TEM


 


134
HLTDGMTVR
no
y7 monocharged
2
TEM


 


135
HLTDGMTVR
no
y8 monocharged
2
TEM


 


136
IVIIYTTGSQATMDER
no
b4 monocharged
2
2br


 


137
IVIIYTTGSQATMDER
no
y2 monocharged
2
2br


 


138
IVIIYTTGSQATMDER
no
y9 monocharged
2
2br


 


139
IVVIYTTGSQATMDEQNR
yes
y5 monocharged
3
2br


 


140
IVVIYTTGSQATMDEQNR
yes
y6 monocharged
3
2br


 


141
IVVIYTTGSQATMDEQNR
yes
y7 monocharged
3
2br


 


142
IVVIYTTGSQATMDEQNR
no
y5 monocharged
3
2br


 


143
IVVIYTTGSQATMDEQNR
no
y6 monocharged
3
2br


 


144
IVVIYTTGSQATMDEQNR
no
y7 monocharged
3
2br


 


145
LDHWEPELNEAVPNDER
no
y5 monocharged
3
2be


 


146
LDHWEPELNEAVPNDER
no
y6 monocharged
3
2be


 


147
LDHWEPELNEAVPNDER
no
y7 monocharged
3
2be


 


148
LLTGELLTLASQQQLIDWMEADK
yes
b8 monocharged
3
TEM


 


149
LLTGELLTLASQQQLIDWMEADK
yes
y6 monocharged
3
TEM


 


150
LLTGELLTLASQQQLIDWMEADK
yes
y7 monocharged
3
TEM


 


151
LLTGELLTLASQQQLIDWMEADK
no
b4 monocharged
3
TEM


 


152
LLTGELLTLASQQQLIDWMEADK
no
y6 monocharged
3
TEM


 


153
LLTGELLTLASQQQLIDWMEADK
no
y7 monocharged
3
TEM


 


154
QIAEIGASLIK
no
y7 monocharged
2
TEM


 


155
QIAEIGASLIK
no
y8 monocharged
2
TEM


 


156
QIAEIGASLIK
no
y9 monocharged
2
TEM


 


157
QTAEIGASLIK
no
y7 monocharged
2
2be


 


158
QTAEIGASLIK
no
y8 monocharged
2
2be


 


159
QTAEIGASLIK
no
y9 monocharged
2
2be


 


160
SGADER
no
y3 monocharged
2
TEM


 


161
SGADER
no
y4 monocharged
2
TEM


 


162
SGADER
no
y5 monocharged
2
TEM


 


163
SGASK
no
y2 monocharged
2
2be


 


164
SGASK
no
y3 monocharged
2
2be


 


165
SGASK
no
y4 monocharged
2
2be


 


166
VAGPLLR
no
y4 monocharged
2
TEM


 


167
VAGPLLR
no
y5 monocharged
2
TEM


 


168
VAGPLLR
no
y6 monocharged
2
TEM


 


169
VGYIEMDLNSGK
yes
y10 dicharged
2
2be


 


170
VGYIEMDLNSGK
yes
y7 monocharged
2
2be


 


171
VGYIEMDLNSGK
yes
y8 monocharged
2
2be


 


172
VGYIEMDLNSGK
no
y7 monocharged
2
2be


 


173
VGYIEMDLNSGK
no
y8 monocharged
2
2be


 


174
VGYIEMDLNSGK
no
y9 monocharged
2
2be


 


175
WEPELNEAIPNDER
no
y12 dicharged
2
TEM


 


176
WEPELNEAIPNDER
no
y5 monocharged
2
TEM


 


177
WEPELNEAIPNDER
no
y7 monocharged
2
TEM


 


178
ELTAFLHNMGEHVTR
no
y7 monocharged
2
2b


 


179
ELTAFLHNMGEHVTR
no
y8 monocharged
2
2b


 


180
ELTAFLHNMGEHVTR
no
y9 monocharged
2
2b


 


181
FPMLSTFK
yes
y6 monocharged
2
TEM


 


182
FPMLSTFK
yes
y7 monocharged
2
TEM


 


183
FPMLSTFK
yes
y7 dicharged
2
TEM


 


184
FPMLSTFK
no
y6 monocharged
2
TEM


 


185
FPMLSTFK
no
y7 monocharged
2
TEM


 


186
FPMLSTFK
no
y7 dicharged
2
TEM


 


187
GSCGIIAALGPDGKPSR
no
y7 monocharged
2
2br


 


188
GSCGIIAALGPDGKPSR
no
y8 monocharged
2
2br


 


189
GSCGIIAALGPDGKPSR
no
y9 monocharged
2
2br


 


190
GSSGIIAALGPDGKPSR
no
y7 monocharged
2
TEM


 


191
GSSGIIAALGPDGKPSR
no
y8 monocharged
2
TEM


 


192
GSSGIIAALGPDGKPSR
no
y9 monocharged
2
TEM


 


193
ILESFRPEK
no
y5 monocharged
2
TEM


 


194
ILESFRPEK
no
y6 monocharged
2
TEM


 


195
ILESFRPEK
no
y7 monocharged
2
TEM


 


196
IVVIYTTGSQATMDELNR
yes
y5 monocharged
3
2br


 


197
IVVIYTTGSQATMDELNR
yes
y6 monocharged
3
2br


 


198
IVVIYTTGSQATMDELNR
yes
y7 monocharged
3
2br


 


199
IVVIYTTGSQATMDELNR
no
y5 monocharged
3
2br


 


200
IVVIYTTGSQATMDELNR
no
y6 monocharged
3
2br


 


201
IVVIYTTGSQATMDELNR
no
y7 monocharged
3
2br


 


202
IVVIYTTGSQATMDER
no
y6 monocharged
2
TEM


 


203
IVVIYTTGSQATMDER
no
y8 monocharged
2
TEM


 


204
IVVIYTTGSQATMDER
no
y9 monocharged
2
TEM


 


205
LHCWEPELNEAIPNDER
no
y5 monocharged
3
2be


 


206
LHCWEPELNEAIPNDER
no
y6 monocharged
3
2be


 


207
LHCWEPELNEAIPNDER
no
y7 monocharged
3
2be


 


208
LLTGELLTLASR
no
y6 monocharged
2
TEM


 


209
LLTGELLTLASR
no
y7 monocharged
2
TEM


 


210
LLTGELLTLASR
no
y9 monocharged
2
TEM


 


211
QQLIDWMADK
yes
y6 monocharged
2
2ber


 


212
QQLIDWMADK
yes
y7 monocharged
2
2ber


 


213
QQLIDWMADK
yes
y8 monocharged
2
2ber


 


214
QQLIDWMADK
no
y6 monocharged
2
2ber


 


215
QQLIDWMADK
no
y7 monocharged
2
2ber


 


216
QQLIDWMADK
no
y8 monocharged
2
2ber


 


217
SALPAGWFIADK
no
y7 monocharged
2
TEM


 


218
SALPAGWFIADK
no
y9 monocharged
2
TEM


 


219
SALPAGWFIADK
no
y9 dicharged
2
TEM


 


220
SGAGVR
no
y3 monocharged
2
2be


 


221
SGAGVR
no
y4 monocharged
2
2be


 


222
SGAGVR
no
y5 monocharged
2
2be


 


223
SGTGER
no
y3 monocharged
2
2be


 


224
SGTGER
no
y4 monocharged
2
2be


 


225
SGTGER
no
y5 monocharged
2
2be


 


226
VALIPFFAAFCIPVFAHPETLVK
no
y11 dicharged
3
2br


 


227
VALIPFFAAFCIPVFAHPETLVK
no
y6 monocharged
3
2br


 


228
VALIPFFAAFCIPVFAHPETLVK
no
y7 monocharged
3
2br


 


229
VLLCGAVLSR
no
y6 monocharged
2
TEM


 


230
VLLCGAVLSR
no
y7 monocharged
2
TEM


 


231
VLLCGAVLSR
no
y8 monocharged
2
TEM


 


232
YSPVTEK
no
y4 monocharged
2
2be


 


233
YSPVTEK
no
y5 monocharged
2
2be


 


234
YSPVTEK
no
y6 monocharged
2
2be


 


235
CEPELNEAIPNDER
no
y12 dicharged
2
2br


 


236
CEPELNEAIPNDER
no
y5 monocharged
2
2br


 


237
CEPELNEAIPNDER
no
y8 monocharged
2
2br


 


238
DAEDQVGAR
no
y5 monocharged
2
2be


 


239
DAEDQVGAR
no
y6 monocharged
2
2be


 


240
DAEDQVGAR
no
y7 monocharged
2
2be


 


241
DTTMPVAMATTLR
no
y7 monocharged
2
TEM


 


242
DTTMPVAMATTLR
no
y9 monocharged
2
TEM


 


243
DTTMPVAMATTLR
no
y9 dicharged
2
TEM


 


244
ELTAFLR
no
y4 monocharged
2
2be


 


245
ELTAFLR
no
y5 monocharged
2
2be


 


246
ELTAFLR
no
y6 monocharged
2
2be


 


247
GSTGIIAALGPDGKPSR
no
y10 monocharged
2
TEM


 


248
GSTGIIAALGPDGKPSR
no
y7 monocharged
2
TEM


 


249
GSTGIIAALGPDGKPSR
no
y9 monocharged
2
TEM


 


250
HLTGGMTVR
yes
y5 monocharged
2
2b


 


251
HLTGGMTVR
yes
y6 monocharged
2
2b


 


252
HLTGGMTVR
yes
y7 monocharged
2
2b


 


253
HLTGGMTVR
no
y5 monocharged
2
2b


 


254
HLTGGMTVR
no
y6 monocharged
2
2b


 


255
HLTGGMTVR
no
y7 monocharged
2
2b


 


256
IVVIYMTGSQATMDELNR
yes
y6 monocharged
3
2ber


 


257
IVVIYMTGSQATMDELNR
yes
y7 monocharged
3
2ber


 


258
IVVIYMTGSQATMDELNR
yes
y8 monocharged
3
2ber


 


259
IVVIYMTGSQATMDELNR
no
y5 monocharged
3
2ber


 


260
IVVIYMTGSQATMDELNR
no
y6 monocharged
3
2ber


 


261
IVVIYMTGSQATMDELNR
no
y7 monocharged
3
2ber


 


262
LDHWEPELNEAIPNDER
no
y5 monocharged
3
2be


 


263
LDHWEPELNEAIPNDER
no
y6 monocharged
3
2be


 


264
LDHWEPELNEAIPNDER
no
y7 monocharged
3
2be


 


265
LLTSELLTLASR
no
y10 monocharged
2
TEM


 


266
LLTSELLTLASR
no
y7 monocharged
2
TEM


 


267
LLTSELLTLASR
no
y9 monocharged
2
TEM


 


268
QIAEIGGSLIK
no
y7 monocharged
2
2ber


 


269
QIAEIGGSLIK
no
y8 monocharged
2
2ber


 


270
QIAEIGGSLIK
no
y9 monocharged
2
2ber


 


271
QQLIDWMEVDK
yes
y6 monocharged
2
TEM


 


272
QQLIDWMEVDK
yes
y7 monocharged
2
TEM


 


273
QQLIDWMEVDK
yes
y8 monocharged
2
TEM


 


274
QQLIDWMEVDK
no
y5 monocharged
2
TEM


 


275
QQLIDWMEVDK
no
y6 monocharged
2
TEM


 


276
QQLIDWMEVDK
no
y7 monocharged
2
TEM


 


277
SVLPAGWFIADK
no
y10 dicharged
2
2be


 


278
SVLPAGWFIADK
no
y9 monocharged
2
2be


 


279
SVLPAGWFIADK
no
y9 dicharged
2
2be


 


280
VAGPLMR
yes
y4 monocharged
2
2br


 


281
VAGPLMR
yes
y5 monocharged
2
2br


 


282
VAGPLMR
yes
y6 monocharged
2
2br


 


283
VAGPLMR
no
y4 monocharged
2
2br


 


284
VAGPLMR
no
y5 monocharged
2
2br


 


285
VAGPLMR
no
y6 monocharged
2
2br


 


286
VALIPFFAAFCLPVFAHPDTLVK
no
y11 dicharged
3
TEM


 


287
VALIPFFAAFCLPVFAHPDTLVK
no
y17 dicharged
3
TEM


 


288
VALIPFFAAFCLPVFAHPDTLVK
no
y6 monocharged
3
TEM


 


289
VALIPFFAAFCLPVFAHPK
no
y15 dicharged
3
TEM


 


290
VALIPFFAAFCLPVFAHPK
no
y7 monocharged
3
TEM


 


291
VALIPFFAAFCLPVFAHPK
no
y9 dicharged
3
TEM


 


292
VEDAEDQLGAR
no
y7 monocharged
2
2b


 


293
VEDAEDQLGAR
no
y8 monocharged
2
2b


 


294
VEDAEDQLGAR
no
y9 monocharged
2
2b


 


295
DAEDQLGSTSGYIELDLNSGK
no
y7 monocharged
3
2ber


 


296
DAEDQLGSTSGYIELDLNSGK
no
y8 monocharged
3
2ber


 


297
DAEDQLGSTSGYIELDLNSGK
no
y9 monocharged
3
2ber


 


298
DTTMPAAMATTLR
no
y7 monocharged
2
TEM


 


299
DTTMPAAMATTLR
no
y8 monocharged
2
TEM


 


300
DTTMPAAMATTLR
no
y9 monocharged
2
TEM


 


301
DTTTPAAMATTLR
yes
y7 monocharged
2
TEM


 


302
DTTTPAAMATTLR
yes
y8 monocharged
2
TEM


 


303
DTTTPAAMATTLR
yes
y9 dicharged
2
TEM


 


304
DTTTPAAMATTLR
no
y7 monocharged
2
TEM


 


305
DTTTPAAMATTLR
no
y9 monocharged
2
TEM


 


306
DTTTPAAMATTLR
no
y9 dicharged
2
TEM


 


307
GSHGIIAALGPDGKPSR
no
b6 monocharged
2
2br


 


308
GSHGIIAALGPDGKPSR
no
y15 dicharged
2
2br


 


309
GSHGIIAALGPDGKPSR
no
y8 monocharged
2
2br


 


310
HLPDGMTVR
no
y5 monocharged
2
TEM


 


311
HLPDGMTVR
no
y7 monocharged
2
TEM


 


312
HLPDGMTVR
no
y8 monocharged
2
TEM


 


313
IHYSQSDLVEYSPVTEK
no
y16 dicharged
2
2be


 


314
IHYSQSDLVEYSPVTEK
no
y7 monocharged
2
2be


 


315
IHYSQSDLVEYSPVTEK
no
y8 monocharged
2
2be


 


316
IVVIYMTGSQATMDER
no
y6 monocharged
2
TEM


 


317
IVVIYMTGSQATMDER
no
y8 monocharged
2
TEM


 


318
IVVIYMTGSQATMDER
no
y9 monocharged
2
TEM


 


319
LLTDELLTLASR
no
y5 monocharged
2
2be


 


320
LLTDELLTLASR
no
y6 monocharged
2
2be


 


321
LLTDELLTLASR
no
y7 monocharged
2
2be


 


322
NMGDHVTR
yes
y4 monocharged
2
2be


 


323
NMGDHVTR
yes
y5 monocharged
2
2be


 


324
NMGDHVTR
yes
y6 monocharged
2
2be


 


325
NMGDHVTR
no
y4 monocharged
2
2be


 


326
NMGDHVTR
no
y5 monocharged
2
2be


 


327
NMGDHVTR
no
y6 monocharged
2
2be


 


328
QIVEIGASLIK
no
y7 monocharged
2
2be


 


329
QIVEIGASLIK
no
y8 monocharged
2
2be


 


330
QIVEIGASLIK
no
y9 monocharged
2
2be


 


331
SGAGER
no
y3 monocharged
2
TEM


 


332
SGAGER
no
y4 monocharged
2
TEM


 


333
SGAGER
no
y5 monocharged
2
TEM


 


334
VAEPLLR
no
y4 monocharged
2
2b


 


335
VAEPLLR
no
y5 monocharged
2
2b


 


336
VAEPLLR
no
y6 monocharged
2
2b


 


337
VALIPFFAAFCFPVFAHPETLVK
no
b11
3
TEM





monocharged


 


338
VALIPFFAAFCFPVFAHPETLVK
no
y11 dicharged
3
TEM


 


339
VALIPFFAAFCFPVFAHPETLVK
no
y6 monocharged
3
TEM


 


340
VALIPFFAAFCLPVFAHPETLVK
no
b7 monocharged
3
TEM


 


341
VALIPFFAAFCLPVFAHPETLVK
no
y11 dicharged
3
TEM


 


342
VALIPFFAAFCLPVFAHPETLVK
no
y6 monocharged
3
TEM


 


343
VDAGQEQLGR
no
y5 monocharged
2
TEM


 


344
VDAGQEQLGR
no
y7 monocharged
2
TEM


 


345
VDAGQEQLGR
no
y8 monocharged
2
TEM


 


346
VGYIELDPNSGK
no
y5 monocharged
2
2be


 


347
VGYIELDPNSGK
no
y7 monocharged
2
2be


 


348
VGYIELDPNSGK
no
y8 monocharged
2
2be









The transitions mentioned in TABLE 3 are detected by using the parameters set out in TABLE 4. The precursor peptide retention time and the transitions, i.e. the (m/z)1 ratio in Q1 and (m/z)2 ratio in Q3, as well as the collision energy used to fragment the precursor ion, are indicated in TABLE 4. The threshold above which the transition is considered to be detected is also indicated in TABLE 4.












TABLE 4






Retention 
(m/z) 
(m/z) 
Collision



Transition
time
filtered 
filtered 
energy 
Positivity


number
(minutes)
in Q1
in Q3
(eV)
threshold




















1
9.9
487.24
416.26
26
2500


2
9.9
487.24
658.36
26
2500


3
9.9
487.24
787.41
26
2500


4
19.3
861.95
512.29
43
2500


5
19.3
861.95
911.47
43
2500


6
19.3
861.95
1048.53
43
2500


7
19.3
859.42
792.37
43
2500


8
19.3
859.42
906.41
43
2500


9
19.3
859.42
1043.47
43
2500


10
18.1
493.751
595.34
27
2500


11
18.1
493.751
742.38
27
2500


12
18.1
493.751
839.43
27
2500


13
19.8
485.757
595.34
26
2500


14
19.8
485.757
726.39
26
2500


15
19.8
485.757
823.44
26
2500


16
15
791.87
698.84
40
2500


17
15
791.87
630.28
40
2500


18
15
791.87
814.41
40
2500


19
19.1
804.96
997.54
40
5000


20
19.1
804.96
813.42
40
5000


21
19.1
804.96
926.51
40
5000


22
16.6
674.67
660.36
38
2500


23
16.6
674.67
823.42
38
2500


24
16.6
674.67
952.46
38
2500


25
14.6
638.34
746.42
33
2500


26
14.6
638.34
972.51
33
2500


27
14.6
638.34
460.73
33
2500


28
15.9
885.44
866.37
44
2500


29
15.9
885.44
923.39
44
2500


30
15.9
885.44
980.41
44
2500


31
17
877.44
722.31
44
2500


32
17
877.44
907.39
44
2500


33
17
877.44
964.42
44
2500


34
19.5
676.32
630.28
38
2500


35
19.5
676.32
743.37
38
2500


36
19.5
676.32
814.41
38
2500


37
18.6
623.35
691.38
32
2500


38
18.6
623.35
804.46
32
2500


39
18.6
623.35
933.51
32
2500


40
1.3
317.15
418.2
19
6000


41
1.3
317.15
489.24
19
6000


42
1.3
317.15
546.26
19
6000


43
1
296.64
391.19
18
2500


44
1
296.64
448.22
18
2500


45
1
296.64
505.24
18
2500


46
10.5
565.78
845.41
30
2500


47
10.6
565.78
916.45
30
2500


48
10.6
565.78
1031.48
30
2500


49
4.1
393.72
462.22
22
2500


50
4.1
393.72
559.27
22
2500


51
4.1
393.72
687.37
22
2500


52
20.1
855.92
698.36
43
2500


53
20.1
855.92
629.33
43
2500


54
20.1
855.92
813.44
43
2500


55
17
585.26
705.36
31
4000


56
17
585.26
852.4
31
4000


57
16.9
585.26
953.44
31
4000


58
13.2
569.27
689.37
30
2500


59
13.2
569.27
820.41
30
2500


60
13.2
569.27
921.45
30
2500


61
18.3
870.93
749.86
43
2500


62
18.3
870.93
512.29
43
2500


63
18.3
870.93
929.43
43
2500


64
14.9
763.36
630.28
39
2500


65
14.9
763.36
814.41
39
2500


66
14.9
763.36
943.45
39
2500


67
14.9
510.73
776.33
27
2500


68
14.9
510.73
873.38
27
2500


69
14.9
510.73
437.2
27
2500


70
18.9
494.74
744.34
27
2500


71
18.9
494.74
841.39
27
2500


72
18.9
494.74
421.2
27
2500


73
15.5
676.39
756.4
35
2500


74
15.5
676.39
813.42
35
2500


75
15.5
676.39
926.51
35
2500


76
11.5
543.78
787.41
29
2500


77
11.5
543.78
858.44
29
2500


78
11.5
543.78
973.47
29
2500


79
12.5
608.82
803.43
32
2500


80
12.5
608.82
966.49
32
2500


81
12.5
608.82
552.28
32
2500


82
15.5
990.98
934.44
49
2500


83
15.5
990.98
573.32
49
2500


84
15.5
990.98
660.36
49
2500


85
19
892.44
722.31
44
2500


86
19
892.44
907.39
44
2500


87
19
892.44
964.42
44
2500


88
19.4
700.65
630.28
39
2500


89
19.4
700.65
743.37
39
2500


90
19.4
700.65
814.41
39
2500


91
10.4
467.73
587.3
26
2500


92
10.4
467.73
700.39
26
2500


93
10.4
467.73
787.42
26
2500


94
12.8
459.73
587.3
25
2500


95
12.8
459.73
700.39
25
2500


96
12.8
459.73
787.42
25
2500


97
20.1
688.83
593.26
35
2500


98
20.1
688.83
779.34
35
2500


99
20.1
688.83
894.37
35
2500


100
1.4
303.646
391.19
18
13000


101
1.4
303.646
462.23
18
13000


102
1.4
303.646
519.25
18
13000


103
31.6
851.81
619.35
47
2500


104
31.6
851.81
686.41
47
2500


105
31.6
851.81
894.5
47
2500


106
18.8
654.35
746.4
34
2500


107
18.8
654.35
875.45
34
2500


108
18.8
654.35
988.53
34
2500


109
16.3
559.31
632.34
30
2500


110
16.3
559.31
792.37
30
2500


111
16.3
559.31
905.45
30
2500


112
10.5
487.73
544.32
26
2500


113
10.5
487.73
659.35
26
2500


114
10.5
487.73
788.39
26
2500


115
12.6
690.35
779.41
35
2500


116
12.6
690.35
947.5
35
2500


117
12.6
690.35
474.26
35
2500


118
15.9
682.35
763.41
35
2500


119
15.9
682.35
931.5
35
2500


120
15.9
682.35
466.26
35
2500


121
19.8
486.75
728.36
26
2500


122
19.8
486.75
825.42
26
2500


123
19.8
486.75
413.21
26
2500


124
18.4
478.75
712.37
26
2500


125
18.4
478.75
809.42
26
2500


126
18.4
478.75
405.21
26
2500


127
16.3
776.93
756.4
39
2500


128
16.3
776.93
813.42
39
2500


129
16.3
776.93
926.51
39
2500


130
12.2
523.26
579.3
28
2500


131
12.2
523.26
795.37
28
2500


132
12.2
523.26
908.45
28
2500


133
12
515.26
506.28
28
2500


134
12
515.26
779.37
28
2500


135
12
515.26
892.46
28
2500


136
18
899.46
439.33
36
2500


137
18
899.46
304.16
57
2500


138
18
899.46
994.43
36
2500


139
15.6
681.33
661.29
38
2500


140
15.6
681.33
808.33
38
2500


141
15.6
681.33
909.37
38
2500


142
16.6
676
661.29
38
3100


143
16.6
676
792.33
38
3100


144
16.6
676
893.38
38
3100


145
17.2
688.32
630.28
38
2500


146
17.2
688.32
729.35
38
2500


147
17.2
688.32
800.39
38
2500


148
27
878.12
841.5
48
2500


149
27
878.12
795.34
48
2500


150
27
878.12
910.37
48
2500


151
27.9
872.79
462.22
48
2500


152
27.9
872.79
779.34
48
2500


153
27.9
872.79
894.37
48
2500


154
18.8
571.84
701.46
30
2500


155
18.8
571.84
830.5
30
2500


156
18.8
571.84
901.54
30
2500


157
16.6
565.82
701.46
30
2500


158
16.6
565.82
830.5
30
2500


159
16.6
565.82
901.54
30
2500


160
1.5
317.64
419.19
19
9000


161
1.5
317.64
490.23
19
9000


162
1.5
317.64
547.25
19
9000


163
0.9
225.12
234.14
18
2500


164
0.9
225.12
305.18
13
2500


165
0.9
225.12
362.2
13
2500


166
14.1
363.24
498.34
21
2500


167
14.1
363.24
555.36
21
2500


168
14.1
363.24
626.4
21
2500


169
14.7
671.32
593.28
35
4500


170
14.7
671.32
780.36
35
4500


171
14.7
671.32
909.4
35
4500


172
17.5
663.32
764.36
34
2500


173
17.5
663.32
893.4
34
2500


174
17.5
663.32
1006.49
34
2500


175
18
856.4
698.84
43
2500


176
18
856.4
630.28
43
2500


177
18
856.4
814.41
43
2500


178
18.6
877.94
829.4
44
2500


179
18.6
877.94
943.44
44
2500


180
18.6
877.94
1080.5
44
2500


181
18.1
493.75
742.38
27
2500


182
18.1
493.75
839.43
27
2500


183
18.1
493.75
420.22
27
2500


184
19.8
485.76
726.39
26
2500


185
19.8
485.76
823.44
26
2500


186
19.8
485.76
412.22
26
2500


187
16.5
828.43
756.4
41
2500


188
16.5
828.43
813.42
41
2500


189
16.5
828.43
926.51
41
2500


190
16.1
791.93
756.4
40
2500


191
16.1
791.93
813.42
40
2500


192
16.1
791.93
926.51
40
2500


193
15.7
559.81
676.38
30
2500


194
14.1
559.81
763.41
30
2500


195
14.1
559.81
892.45
30
2500


196
16.6
676.34
646.31
38
2500


197
16.6
676.34
793.96
38
2500


198
16.6
676.34
894.4
38
2500


199
18.9
671.01
646.31
38
4000


200
18.9
671.01
777.96
38
4000


201
18.9
671.01
878.4
38
4000


202
16.9
892.45
722.31
44
2500


203
16.9
892.45
937.4
44
2500


204
16.9
892.45
994.43
44
2500


205
17.9
707.99
630.28
39
6000


206
17.9
707.99
743.37
39
6000


207
17.9
707.99
814.41
39
6000


208
22.5
643.89
660.4
33
2500


209
22.5
643.89
773.49
33
2500


210
22.5
643.89
959.55
33
2500


211
17.5
632.31
781.32
33
3000


212
17.5
632.31
894.4
33
3000


213
17.5
632.31
1007.49
33
3000


214
19.8
624.31
765.32
32
2500


215
19.8
624.31
878.41
32
2500


216
19.8
624.31
991.49
32
2500


217
21.4
638.34
836.43
33
2500


218
21.4
638.34
1004.52
33
2500


219
21.5
638.34
502.76
33
2500


220
3.2
273.65
331.21
17
2500


221
3.2
273.65
402.25
17
2500


222
3.2
273.65
459.27
17
2500


223
1.3
303.65
361.18
18
21000


224
1.3
303.65
462.23
18
21000


225
1.3
303.65
519.25
18
21000


226
31.3
863.138
619.35
47
2500


227
31.3
863.138
686.41
47
2500


228
31.3
863.138
823.47
47
2500


229
17.7
544.32
602.36
29
2500


230
17.7
544.32
762.39
29
2500


231
17.7
544.32
875.48
29
2500


232
9.8
412.21
476.27
23
2500


233
9.8
412.21
573.32
23
2500


234
9.8
412.21
660.36
23
2500


235
15.2
843.38
698.84
42
2500


236
15.2
843.38
630.28
42
2500


237
15.2
843.38
943.45
42
2500


238
8.7
480.72
530.3
26
2500


239
8.7
480.72
645.33
26
2500


240
8.7
480.72
774.37
26
2500


241
18.8
704.35
763.41
36
2500


242
18.8
704.35
959.53
36
2500


243
18.8
704.35
480.27
36
2500


244
18.3
425.25
506.31
24
2500


245
18.3
425.25
607.36
24
2500


246
18.3
425.25
720.44
24
2500


247
16.4
798.94
997.54
40
2500


248
16.3
798.94
756.4
40
2500


249
16.3
798.94
926.51
40
2500


250
8.3
494.26
850.45
27
2500


251
8.3
494.26
636.31
27
2500


252
8.3
494.26
737.36
27
2500


253
10.9
486.26
834.45
26
2500


254
10.9
486.26
620.32
26
2500


255
10.9
486.26
721.37
26
2500


256
19.3
691.67
793.36
39
2500


257
19.3
691.67
894.4
39
2500


258
19.3
691.67
965.44
39
2500


259
20.6
681.01
646.31
38
2500


260
20.6
681.01
777.36
38
2500


261
20.6
681.01
878.4
38
2500


262
18
692.99
630.28
39
2500


263
18
692.99
743.37
39
2500


264
18
692.99
814.41
39
2500


265
23
658.89
1090.61
34
2500


266
23
658.89
773.49
34
2500


267
23
658.89
989.56
34
2500


268
17.9
564.83
687.44
30
2500


269
17.9
564.83
816.48
30
2500


270
17.9
564.83
887.52
30
2500


271
18.9
710.84
823.37
36
2500


272
18.9
710.84
938.39
36
2500


273
18.9
710.84
1051.48
36
2500


274
20.9
702.84
621.29
36
2500


275
20.9
702.84
807.37
36
2500


276
20.9
702.84
922.4
36
2500


277
22.6
652.36
559.31
34
2500


278
22.6
652.36
1004.52
34
2500


279
22.6
652.36
502.76
34
2500


280
11.1
380.21
532.29
22
2500


281
11.1
380.21
589.31
22
2500


282
11.1
380.21
660.35
22
2500


283
13.1
372.22
516.3
21
2500


284
13.1
372.22
573.32
21
2500


285
13.1
372.22
644.35
21
2500


286
31.3
858.47
612.34
47
2500


287
31.3
858.47
967.1
47
2500


288
31.3
858.47
672.39
47
2500


289
30.5
715.73
874.95
40
2500


290
30.5
715.73
795.45
40
2500


291
30.6
715.73
534.79
40
2500


292
11.7
601.79
788.39
31
2500


293
11.7
601.79
859.43
31
2500


294
11.7
601.79
974.45
31
2500


295
20
738.01
746.4
41
2500


296
20
738.01
875.45
41
2500


297
20
738.01
988.53
41
2500


298
17.6
690.34
763.61
35
2500


299
17.6
690.34
834.45
35
2500


300
17.6
690.34
931.5
35
2500


301
19.5
683.34
779.41
35
6000


302
19.5
683.34
850.45
35
6000


303
19.5
683.34
474.25
35
6000


304
16.1
675.34
763.41
35
2500


305
16.1
675.34
931.5
35
2500


306
16.1
675.34
466.25
35
2500


307
14.4
816.94
565.31
41
2500


308
14.4
816.94
744.92
41
2500


309
14.4
816.94
813.42
41
2500


310
13
513.26
563.3
28
2500


311
13
513.26
775.38
28
2500


312
13
513.26
888.46
28
2500


313
16.6
997.99
941.45
49
2500


314
16.6
997.99
573.32
49
2500


315
16.6
997.99
952.46
49
2500


316
18.9
907.44
722.32
45
2500


317
18.9
907.44
937.4
45
2500


318
18.9
907.44
994.43
45
2500


319
23.7
672.89
547.32
35
2500


320
23.7
672.89
660.4
35
2500


321
23.7
672.89
773.49
35
2500


322
17.1
473.21
528.29
26
2500


323
17.9
473.21
627.32
26
2500


324
17.8
473.21
684.34
26
2500


325
8.4
465.22
512.29
25
9000


326
8.4
465.22
627.32
25
9000


327
8.4
465.22
684.34
25
9000


328
19.8
585.86
701.46
31
2500


329
19.8
585.86
830.5
31
2500


330
19.8
585.86
929.57
31
2500


331
1.3
288.64
361.18
18
8000


332
1.3
288.64
432.22
18
8000


333
1.3
288.64
489.24
18
8000


334
14.5
399.25
498.34
23
6000


335
14.5
399.25
627.38
23
6000


336
14.5
399.25
698.42
23
6000


337
31.3
874.47
823.47
48
2500


338
31.3
874.47
619.41
48
2500


339
31.3
874.47
686.41
48
2500


340
31.3
863.14
823.47
47
2500


341
31.3
863.14
619.34
47
2500


342
31.3
863.14
686.41
47
2500


343
10.6
536.77
602.38
29
2500


344
10.6
536.77
787.41
29
2500


345
10.6
536.77
858.44
29
2500


346
16.5
646.33
502.26
33
7000


347
16.5
646.33
730.37
33
7000


348
16.5
646.33
859.42
33
7000









The other machine parameters used are as follows:













Scan type:
MRM


MRM planned:
yes


Polarity:
Positive


Ionising source:
Turbo V TM (Applied BioSystems)


Q1 setting:
Filtering with unit resolution


Q3 setting:
Filtering with unit resolution









Inter-scan pause:
5.00
msec


Scanning speed:
10
Da/s


Curtain gas:
50.00
psi


Cone voltage:
5500.00
V








Source temperature:
500.00° C.









Nebulising gas:
50.00
psi


Heating gas:
40.00
psi


Collision gas which induces dissociation:
9.00 
psi








Dynamic filling:
activated









Declustering potential (DP):
80.00
V


Entry potential before Q0 (EP):
10.00
V


Collision cell exit potential (CXP):
35
V


Total cycle time:
1.2
sec


Detection window:
90
sec









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the 3 transitions of the same peptide are greater than or equal to the positivity threshold described in TABLE 4, the detection of the peptide is considered to be positive and is labelled “1” in TABLE 5. When at least one transition comprises an area less than the positivity threshold described in TABLE 4, the corresponding peptide is considered non-detected and is labelled 0 in TABLE 5.




















TABLE 5







Transition















number
Sam10
Sam11
Sam12
Sam13
Sam14
Sam15
Sam16
Sam17
Sam18
Sam19
Sam20
Sam21
Sam22





1-3
0
0
0
0
0
0
0
0
0
0
0
0
0


4-6
0
0
0
0
0
0
0
0
0
0
0
0
0


7-9
0
0
0
0
0
0
0
0
0
0
0
0
0


10-12
0
0
0
0
0
0
0
0
0
0
0
0
0


13-15
0
0
0
0
0
0
0
0
0
0
0
0
0


16-18
0
0
0
0
0
0
0
0
0
0
0
0
0


19-21
0
0
0
0
0
0
0
0
0
0
0
0
0


22-24
0
1
0
0
1
0
0
0
0
0
0
1
0


25-27
0
1
0
1
1
0
0
1
1
1
0
1
0


28-30
0
0
0
0
0
0
0
0
0
0
0
0
0


31-33
0
0
0
0
0
0
0
0
0
0
0
0
0


34-36
0
0
0
0
1
0
1
1
1
1
0
1
0


37-39
0
0
0
0
0
0
0
0
0
0
0
0
0


40-42
0
0
0
0
0
0
0
0
0
0
0
0
0


43-45
0
0
0
0
0
0
0
0
0
0
0
0
0


46-48
0
0
0
0
0
0
0
0
0
0
0
0
0


49-51
0
0
0
0
0
0
0
0
0
0
0
0
0


52-54
0
0
0
0
0
0
0
0
0
0
0
0
0


55-57
0
0
0
0
0
0
0
0
0
0
0
0
0


58-60
0
0
0
0
0
0
0
0
0
0
0
0
0


61-63
0
0
0
0
0
0
0
0
0
0
0
0
0


64-66
0
0
0
0
0
0
0
0
0
0
0
0
0


67-69
0
0
0
0
0
0
0
0
0
0
0
0
0


70-72
0
0
0
0
0
0
0
0
0
0
0
0
0


73-75
0
1
1
1
1
1
1
1
1
1
1
1
0


76-78
0
0
0
0
0
0
0
0
0
0
0
0
0


79-81
0
0
0
1
0
0
0
0
1
0
0
0
0


82-84
0
0
0
0
0
0
0
0
0
0
0
0
0


85-87
0
0
0
0
0
0
0
0
0
0
0
0
0


88-90
0
0
0
0
0
0
0
0
0
0
0
0
0


91-93
0
0
0
0
0
0
0
0
0
0
0
0
0


94-96
0
0
0
0
0
0
0
0
0
0
0
0
0


97-99
0
1
1
1
1
1
1
1
1
1
0
1
0


100-102
0
0
0
0
0
0
0
0
0
0
0
0
0


103-105
0
0
0
0
0
0
0
0
0
0
0
0
0


106-108
0
1
1
1
1
1
1
1
1
1
1
1
1


109-111
0
0
0
0
0
0
0
0
0
0
0
0
0


112-114
0
0
0
1
1
0
0
0
1
1
0
0
0


115-117
0
0
0
0
0
0
0
0
0
0
0
0
0


118-120
0
0
0
0
0
0
0
0
0
0
0
0
0


121-123
0
0
0
0
0
0
0
0
0
0
0
0
0


124-126
0
0
0
0
0
0
0
0
0
0
0
0
0


127-129
0
0
0
0
0
0
0
0
0
0
0
0
0


130-132
0
0
0
0
0
0
0
0
0
0
0
0
0


133-135
0
1
0
1
1
0
1
1
1
0
0
1
0


136-138
0
0
0
0
0
0
0
0
0
0
0
0
0


139-141
0
0
0
0
0
0
0
0
0
0
0
0
0


142-144
0
0
0
0
0
0
0
0
0
0
0
0
0


145-147
0
0
0
0
0
0
0
0
0
0
0
0
0


148-150
0
0
0
0
0
0
0
0
0
0
0
0
0


151-153
0
0
0
0
0
0
0
0
0
0
0
0
0


154-156
0
1
1
1
1
1
1
1
1
1
0
1
0


157-159
0
0
0
0
0
0
0
0
0
0
0
0
0


160-162
0
0
0
0
0
0
0
0
0
0
0
0
0


163-165
0
0
0
0
0
0
0
0
0
0
0
0
0


166-168
0
1
1
1
1
1
1
1
1
1
1
1
1


169-171
0
0
0
0
0
0
0
0
0
0
0
0
0


172-174
0
0
0
0
0
0
0
0
0
0
0
0
0


175-177
0
1
0
0
0
0
0
0
0
0
0
0
0


178-180
0
0
0
0
0
0
0
0
0
0
0
0
0


181-183
0
0
0
0
0
0
0
0
0
0
0
0
0


184-186
0
0
0
0
0
0
0
0
0
0
0
0
0


187-189
0
0
0
0
0
0
0
0
0
0
0
0
0


190-192
0
0
0
0
0
0
0
0
0
0
0
0
0


193-195
0
0
0
0
0
0
0
0
0
0
0
0
0


196-198
0
0
0
0
0
0
0
0
0
0
0
0
0


199-201
0
0
0
0
0
0
0
0
0
0
0
0
0


202-204
0
0
0
0
0
0
0
0
0
0
0
0
0


205-207
0
0
0
0
0
0
0
0
0
0
0
0
0


208-210
0
0
1
1
1
1
0
1
1
0
1
1
0


211-213
0
0
0
0
0
0
0
0
0
0
0
0
0


214-216
0
0
0
0
0
0
0
0
0
0
0
0
0


217-219
0
0
0
0
0
0
0
0
0
0
0
0
0


220-222
0
0
0
0
0
0
0
0
0
0
0
0
0


223-225
0
0
0
0
0
0
0
0
0
0
0
0
0


226-228
0
0
0
0
0
0
0
0
0
0
0
0
0


229-231
0
0
0
0
0
0
0
0
0
0
0
0
0


232-234
0
0
1
1
0
1
0
1
1
0
1
0
0


235-237
0
0
0
0
0
0
0
0
0
0
0
0
0


238-240
0
0
0
0
0
0
0
0
0
0
0
0
0


241-243
0
0
0
0
0
0
0
0
0
0
0
0
0


244-246
0
0
0
0
0
0
0
0
0
0
0
0
0


247-249
0
0
0
0
0
0
0
0
0
0
0
0
0


250-252
0
0
0
0
0
0
0
0
0
0
0
0
0


253-255
0
0
0
0
0
0
0
0
0
0
0
0
0


256-258
0
0
0
0
0
0
0
0
0
0
0
0
0


259-261
0
0
0
0
0
0
0
0
0
0
0
0
0


262-264
0
0
0
0
0
1
0
0
0
0
0
0
0


265-267
0
0
0
0
0
0
0
0
0
0
0
0
0


268-270
0
0
0
0
0
0
0
0
0
0
0
0
0


271-273
0
0
0
0
0
0
0
0
0
0
0
0
0


274-276
0
0
0
0
0
0
0
0
0
0
0
0
0


277-279
0
0
0
0
0
0
0
0
0
0
0
0
0


280-282
0
0
0
0
0
0
0
0
0
0
0
0
0


283-285
0
0
0
0
0
0
0
0
0
0
0
0
0


286-288
0
0
0
0
0
0
0
0
0
0
0
0
0


289-291
0
0
0
0
0
0
0
0
0
0
0
0
0


292-294
0
0
0
0
0
0
0
0
0
0
0
0
0


295-297
0
0
0
0
0
0
0
0
0
0
0
0
0


298-300
0
1
0
1
1
0
1
1
1
0
0
1
0


301-303
0
0
0
0
0
0
0
0
0
0
0
0
0


304-306
0
0
0
0
0
0
0
0
0
0
0
0
0


307-309
0
0
0
0
0
0
0
0
0
0
0
0
0


310-312
0
0
0
0
0
0
0
0
0
0
0
0
0


313-315
0
0
0
0
0
0
0
0
0
0
0
0
0


316-318
0
0
0
0
0
0
0
0
0
0
0
0
0


319-321
0
0
0
0
0
0
0
0
0
0
0
0
0


322-324
0
0
0
0
0
0
0
0
0
0
0
0
0


325-327
0
0
0
0
0
0
0
0
0
0
0
0
0


328-330
0
0
0
0
0
0
0
0
0
0
0
0
0


331-333
0
0
0
0
0
0
0
0
0
0
0
0
0


334-336
0
0
0
0
0
0
0
0
0
0
0
0
0


337-339
0
0
0
0
0
0
0
0
0
0
0
0
0


340-342
0
0
0
0
0
0
0
0
0
0
0
0
0


343-345
0
1
1
1
1
1
1
1
1
1
0
1
0


346-348
0
0
0
0
0
0
0
0
0
0
0
0
0


TEM
0
11
8
13
13
9
9
12
14
9
5
12
2


peptides


2b
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides


2br
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides


2be
0
0
1
2
1
2
1
2
3
1
1
1
0


peptides


2ber
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides





Transition


number
Sam23
Sam24
Sam25
Sam26
Sam27
Sam28
Sam29
Sam30
Sam31
Sam32
Sam33
Sam34
Sam35





1-3
0
0
0
0
0
0
0
0
0
0
0
0
0


4-6
0
0
0
0
0
0
0
0
0
0
0
0
0


7-9
0
0
0
0
0
0
0
0
0
0
0
0
0


10-12
0
0
0
0
0
0
0
0
0
0
0
0
0


13-15
0
0
0
0
0
0
0
0
0
0
0
0
0


16-18
0
0
0
0
0
0
0
0
0
0
0
0
0


19-21
0
0
0
0
0
0
0
0
0
0
0
0
0


22-24
0
0
0
0
0
0
0
0
0
0
0
1
1


25-27
1
1
0
1
1
0
0
0
0
0
0
1
1


28-30
0
0
0
0
0
0
0
0
0
0
0
0
0


31-33
0
0
0
0
0
0
0
0
0
0
0
0
0


34-36
1
0
0
0
0
0
0
0
0
1
0
0
0


37-39
0
0
0
0
0
0
0
0
0
0
0
0
0


40-42
0
0
0
0
0
0
0
0
0
0
0
0
0


43-45
0
0
0
0
0
0
0
0
0
0
0
0
0


46-48
0
0
0
0
0
0
0
0
0
0
0
0
0


49-51
0
0
0
0
0
0
0
0
0
0
0
0
0


52-54
0
0
0
0
0
0
0
0
0
0
0
0
0


55-57
0
0
0
0
0
0
0
0
0
0
0
0
0


58-60
0
0
0
0
0
0
0
0
0
0
0
0
0


61-63
0
0
0
0
0
0
0
0
0
0
0
0
0


64-66
0
0
0
0
0
0
0
0
0
0
0
0
0


67-69
0
0
0
0
0
0
0
0
0
0
0
0
0


70-72
0
0
0
0
0
0
0
0
0
0
0
0
0


73-75
1
1
1
1
1
0
1
1
1
1
1
0
0


76-78
0
0
0
0
0
0
0
0
0
0
0
0
0


79-81
0
1
0
1
1
0
0
0
0
1
0
0
0


82-84
0
0
0
0
0
0
0
0
0
0
0
0
0


85-87
0
0
0
0
0
0
0
0
0
0
0
0
0


88-90
0
0
0
0
0
0
0
0
0
0
0
0
0


91-93
0
0
0
0
0
0
0
0
0
0
0
0
0


94-96
0
0
0
0
0
0
0
0
0
0
0
0
0


97-99
1
1
0
1
1
0
0
1
0
0
0
1
1


100-102
0
0
0
0
0
0
0
0
0
0
0
0
0


103-105
0
0
0
0
0
0
0
0
0
0
0
0
0


106-108
1
1
1
1
1
0
1
1
1
1
1
1
1


109-111
0
0
0
0
0
0
0
0
0
0
0
0
0


112-114
1
1
0
1
0
0
0
0
0
0
0
1
1


115-117
0
0
0
0
0
0
0
0
0
0
0
0
0


118-120
0
0
0
0
0
0
0
0
0
0
0
0
0


121-123
0
0
0
0
0
0
0
0
0
0
0
0
0


124-126
0
0
0
0
0
0
0
0
0
0
0
0
0


127-129
0
0
0
0
0
0
0
0
0
0
0
0
0


130-132
0
0
0
0
0
0
0
0
0
0
0
0
0


133-135
1
1
0
1
1
0
0
0
0
1
1
1
1


136-138
0
0
0
0
0
0
0
0
0
0
0
0
0


139-141
0
0
0
0
0
0
0
0
0
0
0
0
0


142-144
0
0
0
0
0
0
0
0
0
0
0
0
0


145-147
0
0
0
0
0
0
0
0
0
0
0
0
0


148-150
0
0
0
0
0
0
0
0
0
0
0
0
0


151-153
0
0
0
0
0
0
0
0
0
0
0
0
0


154-156
1
1
0
1
1
0
1
0
0
0
0
1
1


157-159
0
0
0
0
0
0
0
0
0
0
0
0
0


160-162
0
0
0
0
0
0
0
0
0
0
0
0
0


163-165
0
0
0
0
0
0
0
0
0
0
0
0
0


166-168
1
1
1
1
1
1
1
1
1
1
1
1
1


169-171
0
0
0
0
0
0
0
0
0
0
0
0
0


172-174
0
0
0
0
0
0
0
0
0
0
0
0
0


175-177
0
1
0
1
1
0
0
0
0
0
0
1
1


178-180
0
0
0
0
0
0
0
0
0
0
0
0
0


181-183
0
0
0
0
0
0
0
0
0
0
0
0
0


184-186
0
0
0
0
0
0
0
0
0
0
0
0
0


187-189
0
0
0
0
0
0
0
0
0
0
0
0
1


190-192
0
0
0
0
0
0
0
0
0
0
0
1
0


193-195
0
0
0
0
0
0
0
0
0
0
0
0
0


196-198
0
0
0
0
0
0
0
0
0
0
0
0
0


199-201
0
0
0
0
0
0
0
0
0
0
0
0
0


202-204
0
0
0
0
0
0
0
0
0
0
0
0
0


205-207
0
0
0
0
0
0
0
0
0
0
0
0
0


208-210
1
1
1
1
0
1
0
0
0
1
1
1
1


211-213
0
0
0
0
0
0
0
0
0
0
0
0
0


214-216
0
0
0
0
0
0
0
0
0
0
0
0
0


217-219
0
0
0
0
0
0
0
0
0
0
0
0
0


220-222
0
0
0
0
0
0
0
0
0
0
0
0
0


223-225
0
0
0
0
0
0
0
0
0
0
0
0
0


226-228
0
0
0
0
0
0
0
0
0
0
0
0
0


229-231
0
0
0
0
0
0
0
0
0
0
0
0
0


232-234
0
1
1
1
1
0
1
0
0
1
0
0
0


235-237
0
0
0
0
0
0
0
0
0
0
0
0
0


238-240
0
0
0
0
0
0
0
0
0
0
0
0
0


241-243
0
0
0
0
0
0
0
0
0
0
0
0
0


244-246
0
0
0
0
0
0
0
0
0
0
0
0
0


247-249
0
0
0
0
0
0
0
0
0
0
0
0
0


250-252
0
0
0
0
0
0
0
0
0
0
0
0
0


253-255
0
0
0
0
0
0
0
0
0
0
0
0
0


256-258
0
0
0
0
0
0
0
0
0
0
0
0
0


259-261
0
0
0
0
0
0
0
0
0
0
0
0
0


262-264
0
0
0
0
0
0
0
0
0
0
1
0
0


265-267
0
0
0
0
0
0
0
0
0
0
0
0
0


268-270
0
0
0
0
0
0
0
0
0
0
0
0
0


271-273
0
0
0
0
0
0
0
0
0
0
0
0
0


274-276
0
0
0
0
0
0
0
0
0
0
0
0
0


277-279
0
0
0
0
0
0
0
0
0
0
0
0
0


280-282
0
0
0
0
0
0
0
0
0
0
0
0
0


283-285
0
0
0
0
0
0
0
0
0
0
0
0
0


286-288
0
0
0
0
0
0
0
0
0
0
0
0
0


289-291
0
0
0
0
0
0
0
0
0
0
0
0
0


292-294
0
0
0
0
0
0
0
0
0
0
0
0
0


295-297
0
0
0
0
0
0
0
0
0
0
0
0
0


298-300
1
1
0
0
0
0
0
1
0
0
0
0
0


301-303
0
0
0
0
0
0
0
0
0
0
0
0
0


304-306
0
0
0
0
0
0
0
0
0
0
0
0
0


307-309
0
0
0
0
0
0
0
0
0
0
0
0
0


310-312
0
0
0
0
0
0
0
0
0
0
0
0
0


313-315
0
0
0
0
0
0
0
0
0
0
0
0
0


316-318
0
0
0
0
0
0
0
0
0
0
0
0
0


319-321
0
0
0
0
0
0
0
0
0
0
0
0
0


322-324
0
0
0
0
0
0
0
0
0
0
0
0
0


325-327
0
0
0
0
0
0
0
0
0
0
0
0
0


328-330
0
0
0
0
0
0
0
0
0
0
0
0
0


331-333
0
0
0
0
0
0
0
0
0
0
0
0
0


334-336
0
0
0
0
0
0
0
0
0
0
0
0
0


337-339
0
0
0
0
0
0
0
0
0
0
0
0
0


340-342
0
0
0
0
0
0
0
0
0
0
0
0
0


343-345
1
1
1
1
1
0
1
1
0
1
1
1
1


346-348
0
0
0
0
0
0
0
0
0
0
0
0
0


TEM
12
14
6
13
11
2
6
6
3
9
7
12
12


peptides


2b
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides


2br
0
0
0
0
0
0
0
0
0
0
0
0
1


peptides


2be
1
2
1
2
2
0
1
0
0
3
1
0
0


peptides


2ber
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides





Transition


number
Sam36
Sam37
Sam38
Sam39
Sam40
Sam41
Sam42
Sam43
Sam44
Sam45
Sam46
Sam47
Sam48





1-3
0
0
0
0
0
0
0
0
0
0
0
0
0


4-6
0
0
0
0
0
0
0
0
0
0
0
0
0


7-9
0
0
0
0
0
0
0
0
0
0
0
0
0


10-12
0
0
0
0
0
0
0
0
0
0
0
0
0


13-15
0
0
0
0
0
0
0
0
0
0
0
0
0


16-18
0
0
0
0
0
0
0
0
0
0
0
0
0


19-21
0
0
0
0
0
0
0
0
0
0
0
0
0


22-24
0
0
1
1
0
1
0
0
0
0
0
0
0


25-27
1
0
1
1
1
1
1
0
0
0
1
0
0


28-30
0
0
0
0
0
0
0
0
0
0
0
0
0


31-33
0
0
0
0
0
0
0
0
0
0
0
0
0


34-36
0
0
0
0
0
0
0
0
0
0
0
0
0


37-39
0
0
0
0
0
0
0
0
0
0
0
0
0


40-42
0
0
0
0
0
0
0
0
0
0
0
0
0


43-45
0
0
0
0
0
0
0
0
0
0
0
0
0


46-48
0
0
0
0
0
0
0
0
0
0
0
0
0


49-51
0
0
0
0
0
0
0
0
0
0
0
0
0


52-54
0
0
0
0
0
0
0
0
0
0
0
0
0


55-57
0
0
0
0
0
0
0
0
0
0
0
0
0


58-60
0
0
0
0
0
0
0
0
0
0
0
0
0


61-63
0
0
0
0
0
0
0
0
0
0
0
0
0


64-66
0
0
0
0
0
0
1
0
0
0
0
0
0


67-69
0
0
0
0
0
0
0
0
0
0
0
0
0


70-72
0
0
0
0
0
0
0
0
0
0
0
0
0


73-75
1
1
1
1
1
1
1
1
1
1
1
1
1


76-78
0
0
0
0
0
0
0
0
0
0
0
0
0


79-81
0
0
0
0
0
0
0
0
0
0
1
0
0


82-84
0
0
0
0
0
0
0
0
0
0
0
0
0


85-87
0
0
0
0
0
0
0
0
0
0
0
0
0


88-90
0
0
0
0
0
0
0
0
0
0
0
0
0


91-93
0
0
0
0
0
0
0
0
0
0
0
0
0


94-96
0
0
0
0
0
0
0
0
0
0
0
0
0


97-99
1
0
1
1
1
1
1
0
0
0
1
0
0


100-102
0
0
0
0
0
0
0
0
0
0
0
0
0


103-105
0
0
0
0
0
0
0
0
0
0
0
0
0


106-108
1
1
1
1
1
1
1
1
1
1
1
1
1


109-111
0
0
0
0
0
0
0
0
0
0
0
0
0


112-114
1
0
1
1
1
1
1
0
0
0
1
0
0


115-117
0
0
0
0
0
0
0
0
0
0
0
0
0


118-120
0
0
0
0
0
0
0
0
0
0
0
0
0


121-123
0
0
0
0
0
0
0
0
0
0
0
0
0


124-126
0
0
0
0
0
0
0
0
0
0
0
0
0


127-129
0
0
0
0
0
0
0
0
0
0
0
0
0


130-132
0
0
0
0
0
0
0
0
0
0
0
0
0


133-135
1
1
1
1
1
1
1
1
1
0
1
0
0


136-138
0
0
0
0
0
0
0
0
0
0
0
0
0


139-141
0
0
0
0
0
0
0
0
0
0
0
0
0


142-144
0
0
0
0
0
0
0
0
0
0
0
0
0


145-147
0
0
0
0
0
0
0
0
0
0
0
0
0


148-150
0
0
0
0
0
0
0
0
0
0
0
0
0


151-153
0
0
0
0
0
0
0
0
0
0
0
0
0


154-156
1
0
1
1
1
1
1
0
0
0
1
0
0


157-159
0
0
0
0
0
0
0
0
0
0
0
0
0


160-162
0
0
0
0
0
0
0
0
0
0
0
0
0


163-165
0
0
0
0
0
0
0
0
0
0
0
0
0


166-168
1
1
1
1
1
1
1
1
1
1
1
1
0


169-171
0
0
0
0
0
0
0
0
0
0
0
0
0


172-174
0
0
0
0
0
0
0
0
0
0
0
0
0


175-177
1
0
1
1
1
1
0
0
0
1
1
0
0


178-180
0
0
0
0
0
0
0
0
0
0
0
0
0


181-183
0
0
0
0
0
0
0
0
0
0
0
0
0


184-186
0
0
0
0
0
0
0
0
0
0
0
0
0


187-189
0
0
0
0
0
0
0
0
0
0
0
0
0


190-192
0
0
0
0
0
0
0
0
0
0
0
0
0


193-195
0
0
0
0
0
0
0
0
0
0
0
0
0


196-198
0
0
0
0
0
0
0
0
0
0
0
0
0


199-201
0
0
0
0
0
0
0
0
0
0
0
0
0


202-204
0
0
0
0
0
0
0
0
0
0
0
0
0


205-207
0
0
0
0
0
0
0
0
0
0
0
0
0


208-210
1
1
1
1
1
1
1
1
1
1
1
1
0


211-213
0
0
0
0
0
0
0
0
0
0
0
0
0


214-216
0
0
0
0
0
0
0
0
0
0
0
0
0


217-219
0
0
0
0
0
0
0
0
0
0
0
0
0


220-222
0
0
0
0
0
0
0
0
0
0
0
0
0


223-225
0
0
0
0
0
0
0
0
0
0
0
0
0


226-228
0
0
0
0
0
0
0
0
0
0
0
0
0


229-231
0
0
0
0
0
0
0
0
0
0
0
0
0


232-234
0
0
0
0
0
0
0
0
1
0
1
0
0


235-237
0
0
0
0
0
0
0
0
0
0
0
0
0


238-240
0
0
0
0
0
0
0
0
0
0
0
0
0


241-243
0
0
0
0
0
0
0
0
0
0
0
0
0


244-246
0
0
0
0
0
0
0
0
0
0
0
0
0


247-249
0
0
0
0
0
0
0
0
0
0
0
0
0


250-252
0
0
0
0
0
0
0
0
0
0
0
0
0


253-255
0
0
0
0
0
0
0
0
0
0
0
0
0


256-258
0
0
0
0
0
0
0
0
0
0
0
0
0


259-261
0
0
0
0
0
0
0
0
0
0
0
0
0


262-264
0
0
0
0
0
0
0
0
0
0
0
0
0


265-267
0
0
0
0
0
0
0
0
0
0
0
0
0


268-270
0
0
0
0
0
0
0
0
0
0
0
0
0


271-273
0
0
0
0
0
0
0
0
0
0
0
0
0


274-276
0
0
0
0
0
0
0
0
0
0
0
0
0


277-279
0
0
0
0
0
0
0
0
0
0
0
0
0


280-282
0
0
0
0
0
0
0
0
0
0
0
0
0


283-285
0
0
0
0
0
0
0
0
0
0
0
0
0


286-288
0
0
0
0
0
0
0
0
0
0
0
0
0


289-291
0
0
0
0
0
0
0
0
0
0
0
0
0


292-294
0
0
0
0
0
0
0
0
0
0
0
0
0


295-297
0
0
0
0
0
0
0
0
0
0
0
0
0


298-300
1
0
1
1
0
1
1
0
0
0
0
0
0


301-303
0
0
0
0
0
0
0
0
0
0
0
0
0


304-306
0
0
0
0
0
0
0
0
0
0
1
0
0


307-309
0
0
0
0
0
0
0
0
0
0
0
0
0


310-312
0
0
0
0
0
0
0
0
0
0
0
0
0


313-315
0
0
0
0
0
0
0
0
0
0
0
0
0


316-318
0
0
0
0
0
0
0
0
0
0
0
0
0


319-321
0
0
0
0
0
0
0
0
0
0
0
0
0


322-324
0
0
0
0
0
0
0
0
0
0
0
0
0


325-327
0
0
0
0
0
0
0
0
0
0
0
0
0


328-330
0
0
0
0
0
0
0
0
0
0
0
0
0


331-333
0
0
0
0
0
0
0
0
0
0
0
0
0


334-336
0
0
0
0
0
0
0
0
0
0
0
0
0


337-339
0
0
0
0
0
0
0
0
0
0
0
0
0


340-342
0
0
0
0
0
0
0
0
0
0
0
0
0


343-345
1
1
1
1
1
1
1
1
1
1
1
1
0


346-348
0
0
0
0
0
0
0
0
0
0
0
0
0


TEM
12
6
13
13
11
13
12
6
7
6
14
5
2


peptides


2b
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides


2br
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides


2be
0
0
0
0
0
0
0
0
1
0
2
0
0


peptides


2ber
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides





Transition


number
Sam49
Sam50
Sam51
Sam52
Sam53
Sam54
Sam55
Sam56
Sam57
Sam58
Sam59
Sam60
Sam61





1-3
0
0
0
0
0
0
0
0
0
0
0
0
0


4-6
0
0
0
0
0
0
0
0
0
0
0
0
0


7-9
0
0
0
0
0
0
0
0
0
0
0
0
0


10-12
0
0
0
0
0
0
0
0
0
0
0
0
0


13-15
0
0
0
0
0
0
0
0
0
0
0
0
0


16-18
0
0
0
0
0
0
0
0
0
0
0
0
0


19-21
0
0
0
0
0
0
0
0
0
0
0
0
0


22-24
0
0
0
0
1
0
0
1
0
0
0
0
0


25-27
0
1
1
1
1
0
1
1
1
1
1
1
1


28-30
0
0
0
0
0
0
0
0
0
0
0
0
0


31-33
0
0
0
0
0
0
0
0
0
0
0
0
0


34-36
0
0
0
0
0
0
0
0
0
1
1
0
1


37-39
0
0
0
0
0
0
0
0
0
0
0
0
0


40-42
0
0
0
0
0
0
0
0
0
0
0
0
0


43-45
0
0
0
0
0
0
0
0
0
0
0
0
0


46-48
0
0
0
0
0
0
0
0
0
0
0
0
0


49-51
0
0
0
0
0
0
0
0
0
0
0
0
0


52-54
0
0
0
0
0
0
0
0
0
0
0
0
0


55-57
0
0
0
0
0
0
0
0
0
0
0
0
0


58-60
0
0
0
0
0
0
0
0
0
0
0
0
0


61-63
0
0
0
0
0
0
0
0
0
0
0
0
0


64-66
0
0
0
0
0
0
0
0
0
0
0
0
0


67-69
0
0
0
0
0
0
0
0
0
0
0
0
0


70-72
0
0
0
0
0
0
0
0
0
0
0
0
0


73-75
0
0
0
1
1
0
1
1
1
1
0
1
1


76-78
0
0
0
0
0
0
0
0
0
0
0
0
0


79-81
0
0
0
1
0
0
1
0
1
0
1
0
1


82-84
0
0
0
0
0
0
0
0
0
0
0
0
0


85-87
0
0
0
0
0
0
0
0
0
0
0
0
0


88-90
0
0
0
0
0
0
0
0
0
0
0
0
0


91-93
0
0
0
0
0
0
0
0
0
0
0
0
0


94-96
0
0
0
0
0
0
0
0
0
0
0
0
0


97-99
0
1
0
0
1
0
0
1
1
1
1
0
0


100-102
0
0
0
0
0
0
0
0
0
0
0
0
0


103-105
0
0
0
0
0
0
0
0
0
0
0
0
0


106-108
1
1
1
1
1
0
1
1
1
1
1
1
1


109-111
0
0
0
0
0
0
0
0
0
0
0
0
0


112-114
0
1
1
1
1
0
1
1
0
0
0
0
0


115-117
0
0
0
0
0
0
0
0
0
0
0
0
0


118-120
0
0
0
0
0
0
0
0
0
0
0
0
0


121-123
0
0
0
0
0
0
0
0
0
0
0
0
0


124-126
0
0
0
0
0
0
0
0
0
0
0
0
0


127-129
0
0
0
0
0
0
0
0
0
0
0
0
0


130-132
0
0
0
0
0
0
0
0
0
0
0
0
0


133-135
0
1
0
1
1
0
1
1
1
1
1
1
0


136-138
0
0
0
0
0
0
0
0
0
0
0
0
0


139-141
0
0
0
0
0
0
0
0
0
0
0
0
0


142-144
0
0
0
0
0
0
0
0
0
0
0
0
0


145-147
0
0
0
0
0
0
0
0
0
0
0
0
0


148-150
0
0
0
0
0
0
0
0
0
0
0
0
0


151-153
0
0
0
0
0
0
0
0
0
0
0
0
0


154-156
0
1
0
1
1
0
0
1
1
1
1
1
0


157-159
0
0
0
0
0
0
0
0
0
0
0
0
0


160-162
0
0
0
0
0
0
0
0
0
0
0
0
0


163-165
0
0
0
0
0
0
0
0
0
0
0
0
0


166-168
1
1
1
1
1
0
1
1
1
1
1
1
1


169-171
0
0
0
0
0
0
0
0
0
0
0
0
0


172-174
0
0
0
0
0
0
0
0
0
0
0
0
0


175-177
1
1
1
1
1
0
1
1
1
0
0
1
0


178-180
0
0
0
0
0
0
0
0
0
0
0
0
0


181-183
0
0
0
0
0
0
0
0
0
0
0
0
0


184-186
0
0
0
0
0
0
0
0
0
0
0
0
0


187-189
1
1
0
0
0
0
0
0
0
0
0
0
0


190-192
0
0
1
0
0
0
0
0
0
0
1
0
0


193-195
0
0
0
0
0
0
0
0
0
0
0
0
0


196-198
0
0
0
0
0
0
0
0
0
0
0
0
0


199-201
0
0
0
0
0
0
0
0
0
0
0
0
0


202-204
0
0
0
0
0
0
0
0
0
0
0
0
0


205-207
0
0
0
0
0
0
0
0
0
0
0
0
0


208-210
0
0
0
0
1
0
1
1
0
1
1
1
1


211-213
0
0
0
0
0
0
0
0
0
0
0
0
0


214-216
0
0
0
0
0
0
0
0
0
0
0
0
0


217-219
0
0
0
0
0
0
0
0
0
0
0
0
0


220-222
0
0
0
0
0
0
0
0
0
0
0
0
0


223-225
0
0
0
0
0
0
0
0
0
0
0
0
0


226-228
0
0
0
0
0
0
0
0
0
0
0
0
0


229-231
0
0
0
0
0
0
0
0
0
0
0
0
0


232-234
0
0
0
1
0
0
1
0
1
0
1
0
1


235-237
0
0
0
0
0
0
0
0
0
0
0
0
0


238-240
0
0
0
0
0
0
0
0
0
0
0
0
0


241-243
0
0
0
0
0
0
0
0
0
0
0
0
0


244-246
0
0
0
0
0
0
0
0
0
0
0
0
0


247-249
0
0
0
0
0
0
0
0
0
0
0
0
0


250-252
0
0
0
0
0
0
0
0
0
0
0
0
0


253-255
0
0
0
0
0
0
0
0
0
0
0
0
0


256-258
0
0
0
0
0
0
0
0
0
0
0
0
0


259-261
0
0
0
0
0
0
0
0
0
0
0
0
0


262-264
0
0
0
0
0
0
0
0
0
0
0
0
0


265-267
0
0
0
0
0
0
0
0
0
0
0
0
0


268-270
0
0
0
0
0
0
0
0
0
0
0
0
0


271-273
0
0
0
0
0
0
0
0
0
0
0
0
0


274-276
0
0
0
0
0
0
0
0
0
0
0
0
0


277-279
0
0
0
0
0
0
0
0
0
0
0
0
0


280-282
0
0
0
0
0
0
0
0
0
0
0
0
0


283-285
0
0
0
0
0
0
0
0
0
0
0
0
0


286-288
0
0
0
0
0
0
0
0
0
0
0
0
0


289-291
0
0
0
0
0
0
0
0
0
0
0
0
0


292-294
0
0
0
0
0
0
0
0
0
0
0
0
0


295-297
0
0
0
0
0
0
0
0
0
0
0
0
0


298-300
0
0
0
0
0
0
1
1
0
0
1
0
0


301-303
0
0
0
0
0
0
0
0
0
0
0
0
0


304-306
0
0
0
1
1
0
0
0
1
0
0
0
0


307-309
0
0
0
0
0
0
0
0
0
0
0
0
0


310-312
0
0
0
0
0
0
0
0
0
0
0
0
0


313-315
0
0
0
0
0
0
0
0
0
0
0
0
0


316-318
0
0
0
0
0
0
0
0
0
0
0
0
0


319-321
0
0
0
0
0
0
0
0
0
0
0
0
0


322-324
0
0
0
0
0
0
0
0
0
0
0
0
0


325-327
0
0
0
0
0
0
0
0
0
0
0
0
0


328-330
0
0
0
0
0
0
0
0
0
0
0
0
0


331-333
0
0
0
0
0
0
0
0
0
0
0
0
0


334-336
0
0
0
0
0
0
0
0
0
0
0
0
0


337-339
0
0
0
0
0
0
0
0
0
0
0
0
0


340-342
0
0
0
0
0
0
0
0
0
0
0
0
0


343-345
1
1
1
1
1
1
1
1
1
1
1
1
1


346-348
0
0
0
0
0
0
0
0
0
0
0
0
0


TEM
5
10
7
12
13
1
12
13
12
10
13
9
9


peptides


2b
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides


2br
1
1
0
0
0
0
0
0
0
0
0
0
0


peptides


2be
0
0
0
2
0
0
2
0
2
1
3
2
3


peptides


2ber
0
0
0
0
0
0
0
0
0
0
0
0
0


peptides









Sample Sam10 does not present any peptide which is characteristic of TEMs. The bacteria present in sample Sam10 may be sensitive to cephalosporins and to penicillins.
Samples Sam11 to Sam61 comprise at least one peptide which is characteristic of TEMs. The bacteria present in samples Sam11 to Sam61 therefore express a beta-lactamase which confers on them a resistance to penicillins.
No peptide specific to phenotype 2b is observed, and no sample tested is identified as being resistant solely to penicillins.
Samples Sam35, Sam49 and Sam50 comprise at least one peptide specific to phenotype 2br. Samples Sam35, Sam49 and Sam50 are therefore resistant to penicillins associated with an inhibitor of the clavulanic acid and tazobactam type.
No peptide specific to phenotype 2ber is observed, and no sample tested is identified as belonging only to this phenotype.
Samples Sam12 to Sam21, Sam23 to Sam27, Sam29, Sam32, Sam33, Sam44, Sam46, Sam52, Sam55 and Sam57 to Sam61 comprise at least one peptide specific to the phenotype 2be or to the phenotype 2ber. Samples Sam12 to Sam21, Sam23 to Sam27, Sam29, Sam32, Sam33, Sam44, Sam46, Sam52, Sam55, and Sam57 to Sam61 are therefore resistant to penicillins, to cephalosporins and to monobactams.
EXAMPLE 7
Identification of a Resistance to CMY Beta-Lactams
The samples corresponding to a species able to comprise a CMY resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 6 instead of the peptides from TABLE 3.














TABLE 6








Charge









state

(m/z)
(m/z)


Transition

Fragment
of the
Retention
filtered in
filtered
Collision


number
Peptide
ion
precursor
time
Q1
in Q3
energy






















1
LSDPVTK
y6
2
10
380.22
646.34
22


 


2
LSDPVTK
y5
2
10
380.22
559.31
22


 


3
LSDPVTK
y4
2
10
380.22
444.28
22


 


4
ADSIINGSDSK
y9
2
10.2
553.77
920.47
29


 


5
ADSIINGSDSK
y8
2
10.2
553.77
833.44
29


 


6
ADSIINGSDSK
y7
2
10.2
553.77
720.35
29


 


7
ASWVHK
y5
2
11.6
364.2
656.35
21


 


8
ASWVHK
y4
2
11.6
364.2
569.32
21


 


9
ASWVHK
y3
2
11.6
364.2
383.24
21


 


10
SYPNPVR
y6
2
11.6
416.72
745.4
23


 


11
SYPNPVR
y5
2
11.6
416.72
582.34
23


 


12
SYPNPVR
y4
2
11.6
416.72
485.28
23


 


13
VEAAWR
y5
2
12.3
366.2
632.32
21


 


14
VEAAWR
y4
2
12.3
366.2
503.27
21


 


15
VEAAWR
y3
2
12.3
366.2
432.24
21


 


16
QWQGIR
y5
2
13.8
394.21
659.36
22


 


17
QWQGIR
y4
2
13.8
394.21
473.28
22


 


18
QWQGIR
y3
2
13.8
394.21
345.22
22


 


19
VLQPLK
y5
2
14
349.23
598.39
20


 


20
VLQPLK
y4
2
14
349.23
485.31
20


 


21
VLQPLK
y3
2
14
349.23
357.25
20


 


22
SSVIDMAR
y7
2
14.2
439.72
791.41
24


 


23
SSVIDMAR
y6
2
14.2
439.72
704.38
24


 


24
SSVIDMAR
y5
2
14.2
439.72
605.31
24


 


25
WVQANMDASHVQEK
y9
2
14.4
821.89
1044.48
41


 


26
WVQANMDASHVQEK
y8
2
14.4
821.89
913.44
41


 


27
WVQANMDASHVQEK
y7
2
14.4
821.89
798.41
41


 


28
TLQQGIALAQSR
y9
2
15.2
643.36
943.53
33


 


29
TLQQGIALAQSR
y8
2
15.2
643.36
815.47
33


 


30
TLQQGIALAQSR
y7
2
15.2
643.36
758.45
33


 


31
TEQQIADIVNR
y9
2
15.6
643.84
1056.58
33


 


32
TEQQIADIVNR
y8
2
15.6
643.84
928.52
33


 


33
TEQQIADIVNR
y7
2
15.6
643.84
800.46
33


 


34
LAHTWITVPQNEQK
y9
2
16
832.94
1056.57
42


 


35
LAHTWITVPQNEQK
y8
2
16
832.94
943.48
42


 


36
LAHTWITVPQNEQK
y7
2
16
832.94
842.44
42


 


37
DYAWGYR
y6
2
16.4
465.71
815.38
25


 


38
DYAWGYR
y5
2
16.4
465.71
652.32
25


 


39
DYAWGYR
y4
2
16.4
465.71
581.28
25


 


40
YWPELTGK
y7
2
17.4
497.26
830.44
27


 


41
YWPELTGK
y6
2
17.4
497.26
644.36
27


 


42
YWPELTGK
y5
2
17.4
497.26
547.31
27


 


43
TFNGVLGGDAIAR
y9
2
17.6
645.84
871.5
33


 


44
TFNGVLGGDAIAR
y8
2
17.6
645.84
772.43
33


 


45
TFNGVLGGDAIAR
y7
2
17.6
645.84
659.35
33


 


46
NLGIVMLANK
y9
2
19.1
536.81
958.58
29


 


47
NLGIVMLANK
y8
2
19.1
536.81
845.49
29


 


48
NLGIVMLANK
y7
2
19.1
536.81
788.47
29


 


49
TGSTGGFGSYVAFVPEK
y9
2
19.5
852.42
1039.55
43


 


50
TGSTGGFGSYVAFVPEK
y8
2
19.5
852.42
952.51
43


 


51
TGSTGGFGSYVAFVPEK
y7
2
19.5
852.42
789.45
43


 


52
ADIANNHPVTQQTLFELGSVSK
y9
3
20
790.41
979.55
44


 


53
ADIANNHPVTQQTLFELGSVSK
y8
3
20
790.41
866.46
44


 


54
ADIANNHPVTQQTLFELGSVSK
y7
3
20
790.41
719.39
44


 


55
VALAALPAVEVNPPAPAVK
y9
2
20.4
914.04
892.53
45


 


56
VALAALPAVEVNPPAPAVK
y8
2
20.4
914.04
793.46
45


 


57
VALAALPAVEVNPPAPAVK
y7
2
20.4
914.04
679.41
45


 


58
LLHLATYTAGGLPLQIPDDVR
y9
3
22.4
755.09
1052.57
42


 


59
LLHLATYTAGGLPLQIPDDVR
y8
3
22.4
755.09
955.52
42


 


60
LLHLATYTAGGLPLQIPDDVR
y7
3
22.4
755.09
842.44
42


 


61
TITPLMQEQAIPGMAVAVIYQGK
y9
3
22.5
820.44
948.55
45


 


62
TITPLMQEQAIPGMAVAVIYQGK
y8
3
22.5
820.44
877.51
45


 


63
TITPLMQEQAIPGMAVAVIYQGK
y7
3
22.5
820.44
778.45
45


 


64
AALLHFYQNWQPQWTPGAK
y9
3
23.2
752.72
1012.52
42


 


65
AALLHFYQNWQPQWTPGAK
y8
3
23.2
752.72
884.46
42


 


66
AALLHFYQNWQPQWTPGAK
y7
3
23.2
752.72
787.41
42


 


67
LYANSSIGLFGALAVK
y9
2
25.1
812.46
875.53
41


 


68
LYANSSIGLFGALAVK
y8
2
25.1
812.46
818.51
41


 


69
LYANSSIGLFGALAVK
y7
2
25.1
812.46
705.43
41


 


70
SLCCALLLTASFSTFAAAK
y9
3
25.4
678.01
929.47
38


 


71
SLCCALLLTASFSTFAAAK
y8
3
25.4
678.01
842.44
38


 


72
SLCCALLLTASFSTFAAAK
y7
3
25.4
678.01
695.37
38


 


73
IGDMYQGLGWEMLNWPLK
y9
3
28.5
717.68
1216.62
40


 


74
IGDMYQGLGWEMLNWPLK
y8
3
28.5
717.68
1030.54
40


 


75
IGDMYQGLGWEMLNWPLK
y7
3
28.5
717.68
901.5
40


 


76
AHYFNYGVANR
y7
2
15.5
656.32
793.4
34


 


77
AHYFNYGVANR
y8
2
15.5
656.32
940.46
34


 


78
AHYFNYGVANR
y9
2
15.5
656.32
1103.53
34


 


79
ANIGGVDDK
y5
2
9.6
444.72
533.26
25


 


80
ANIGGVDDK
y6
2
9.6
444.72
590.28
25


 


81
ANIGGVDDK
y7
2
9.6
444.72
703.36
25


 


82
ESGSQVLFNK
y6
2
15.1
554.79
748.44
29


 


83
ESGSQVLFNK
y7
2
15.1
554.79
835.47
29


 


84
ESGSQVLFNK
y8
2
15.1
554.79
892.49
29


 


85
GAMQLDDK
y5
2
11.5
439.21
618.31
24


 


86
GAMQLDDK
y6
2
11.5
439.21
749.35
24


 


87
GAMQLDDK
y7
2
11.5
439.21
820.39
24


 


88
GIGIVMLANR
y6
2
18.7
522.31
703.39
28


 


89
GIGIVMLANR
y7
2
18.7
522.31
816.48
28


 


90
GIGIVMLANR
y8
2
18.7
522.31
873.5
28


 


91
HAPWLK
y4
2
15
376.22
543.33
22


 


92
HAPWLK
y5
2
15
376.22
614.37
22


 


93
HAPWLK
b5
2
15
376.22
605.32
22


 


94
IPGMAVAVLK
y6
2
18.1
499.81
600.41
27


 


95
IPGMAVAVLK
y7
2
18.1
499.81
731.45
27


 


96
IPGMAVAVLK
y8
2
18.1
499.81
788.47
27


 


97
PVVDASIQPLLK
y7
2
19.3
640.38
798.51
33


 


98
PVVDASIQPLLK
y8
2
19.3
640.38
869.55
33


 


99
PVVDASIQPLLK
y9
2
19.3
640.38
984.57
33


 


100
QAMASYAYGYSK
y7
2
15.5
670.3
851.39
34


 


101
QAMASYAYGYSK
y8
2
15.5
670.3
938.43
34


 


102
QAMASYAYGYSK
y9
2
15.5
670.3
1009.46
34


 


103
QWAPVYSPGSHR
y8
2
14.8
692.84
902.45
35


 


104
QWAPVYSPGSHR
y9
2
14.8
692.84
999.5
35


 


105
QWAPVYSPGSHR
y10
2
14.8
692.84
1070.54
35


 


106
QYSNPSIGLFGHLAASSLK
y11
2
22
995.52
1143.65
49


 


107
QYSNPSIGLFGHLAASSLK
y12
2
22
995.52
1200.67
49


 


108
QYSNPSIGLFGHLAASSLK
y11
2
22
664.02
1143.65
37


 


109
TGSTNGFGAYVAFVPAR
y9
2
19.4
857.93
993.55
43


 


110
TGSTNGFGAYVAFVPAR
y10
2
19.4
857.93
1050.57
43


 


111
TGSTNGFGAYVAFVPAR
y11
2
19.4
857.93
1197.64
43


 


112
TLTATLGAYAVVK
y8
2
18.3
654.38
820.49
34


 


113
TLTATLGAYAVVK
y9
2
18.3
654.38
921.54
34


 


114
TLTATLGAYAVVK
y10
2
18.3
654.38
992.58
34


 


115
VNPGMLADEAYGIK
y8
2
18.8
739.37
866.43
38


 


116
VNPGMLADEAYGIK
y9
2
18.8
739.37
979.51
38


 


117
VNPGMLADEAYGIK
y10
2
18.8
739.37
1110.55
38


 


118
PSGMSYEEAMTR
y10
2
15.5
679.79
1174.49
35


 


119
PSGMSYEEAMTR
y9
2
15.5
679.79
1117.47
35


 


120
PSGMSYEEAMTR
y8
2
15.5
679.79
986.42
35


 


121
PYYFTWGK
y7
2
20.3
531.26
964.46
29


 


122
PYYFTWGK
y6
2
20.3
531.26
801.39
29


 


123
PYYFTWGK
y5
2
20.3
531.26
638.33
29









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the 3 transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 8
Identification of a Resistance to CTX-M Beta-Lactams
The samples corresponding to a species able to comprise a CTX-M resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 7 instead of the peptides from TABLE 3.














TABLE 7







Charge









state of
first-
Retention
(m/z)
(m/z)
Collision


Transition

the
generation
time
filtered
filtered
energy


number
Peptide
precursor
fragment ion
(minutes)
in Q1
in Q3
(eV)






















1
AGLPK
2
y4
9.5
243.16
414.27
16


 


2
AGLPK
2
y3
9.5
243.16
357.25
16


 


3
AGLPK
2
y2
9.5
243.16
244.17
16


 


4
AGLPTSWTVGDK
2
y9
16.6
616.32
990.49
32


 


5
AGLPTSWTVGDK
2
y8
16.6
616.32
893.44
32


 


6
AGLPTSWTVGDK
2
y7
16.6
616.32
792.39
32


 


7
AIGDETFR
2
y7
14
454.73
837.41
25


 


8
AIGDETFR
2
y6
14
454.73
724.33
25


 


9
AIGDETFR
2
y5
14
454.73
667.3
25


 


10
ALAETQR
2
y6
7.4
394.72
717.39
22


 


11
ALAETQR
2
y5
7.4
394.72
604.3
22


 


12
ALAETQR
2
y4
7.4
394.72
533.27
22


 


13
ALGDSQR
2
y6
7
373.69
675.34
21


 


14
ALGDSQR
2
y5
7
373.69
562.26
21


 


15
ALGDSQR
2
y4
7
373.69
505.24
21


 


16
AMAQTLR
2
y6
12.1
395.72
719.39
22


 


17
AMAQTLR
2
y5
12.1
395.72
588.35
22


 


18
AMAQTLR
2
y4
12.1
395.72
517.31
22


 


19
APLILVTYFTQPQPK
2
y9
22.4
858.49
1109.6
43


 


20
APLILVTYFTQPQPK
2
y8
22.4
858.49
1008.5
43


 


21
APLILVTYFTQPQPK
2
y7
22.4
858.49
845.45
43


 


22
APLVLVTYFTQPQQNAESR
3
y9
21.4
721.38
1057.5
40


 


23
APLVLVTYFTQPQQNAESR
3
y8
21.4
721.38
929.44
40


 


24
APLVLVTYFTQPQQNAESR
3
y7
21.4
721.38
832.39
40


 


25
AQLVTWLK
2
y7
21
479.79
887.53
26


 


26
AQLVTWLK
2
y6
21
479.79
759.48
26


 


27
AQLVTWLK
2
y5
21
479.79
646.39
26


 


28
AQLVTWMK
2
y7
19
488.77
905.49
27


 


29
AQLVTWMK
2
y6
19
488.77
777.43
27


 


30
AQLVTWMK
2
y5
19
488.77
664.35
27


 


31
DILAAAAK
2
y7
12.1
386.73
657.43
22


 


32
DILAAAAK
2
y6
12.1
386.73
544.35
22


 


33
DILAAAAK
2
y5
12.1
386.73
431.26
22


 


34
DTTSPR
2
y5
4.6
338.67
561.3
20


 


35
DTTSPR
2
y4
4.6
338.67
460.25
20


 


36
DTTSPR
2
y3
4.6
338.67
359.2
20


 


37
DTTTPLAMAQTLK
2
y9
17
695.87
972.55
36


 


38
DTTTPLAMAQTLK
2
y8
17
695.87
875.5
36


 


39
DTTTPLAMAQTLK
2
y7
17
695.87
762.42
36


 


40
DTTTPR
2
y5
4.8
345.67
575.31
20


 


41
DTTTPR
2
y4
4.8
345.67
474.27
20


 


42
DTTTPR
2
y3
4.8
345.67
373.22
20


 


43
DVLAAAAK
2
y7
10.5
379.72
643.41
22


 


44
DVLAAAAK
2
y6
10.5
379.72
544.35
22


 


45
DVLAAAAK
2
y5
10.5
379.72
431.26
22


 


46
DVLASAAK
2
y7
10.8
387.72
659.41
22


 


47
DVLASAAK
2
y6
10.8
387.72
560.34
22


 


48
DVLASAAK
2
y5
10.8
387.72
447.26
22


 


49
DVLASAAR
2
y7
11.4
401.72
687.41
23


 


50
DVLASAAR
2
y6
11.4
401.72
588.35
23


 


51
DVLASAAR
2
y5
11.4
401.72
475.26
23


 


52
FAMCSTSK
2
y7
11.1
466.2
784.33
26


 


53
FAMCSTSK
2
y6
11.1
466.2
713.3
26


 


54
FAMCSTSK
2
y5
11.1
466.2
582.26
26


 


55
FPMCSTSK
2
y7
12.1
479.21
810.35
26


 


56
FPMCSTSK
2
y6
12.1
479.21
713.3
26


 


57
FPMCSTSK
2
y5
12.1
479.21
582.26
26


 


58
GNTTGAASIQAGLPASWVVGDK
3
y9
19.5
700.7
958.5
39


 


59
GNTTGAASIQAGLPASWVVGDK
3
y8
19.5
700.7
861.45
39


 


60
GNTTGAASIQAGLPASWVVGDK
3
y7
19.5
700.7
790.41
39


 


61
GNTTGAASIQAGLPTSWVVGDK
3
y9
19.3
710.7
988.51
40


 


62
GNTTGAASIQAGLPTSWVVGDK
3
y8
19.3
710.7
891.46
40


 


63
GNTTGAASIQAGLPTSWVVGDK
3
y7
19.3
710.7
790.41
40


 


64
GNTTGAASIR
2
y9
9
474.25
890.47
26


 


65
GNTTGAASIR
2
y8
9
474.25
776.43
26


 


66
GNTTGAASIR
2
y7
9
474.25
675.38
26


 


67
GNTTGSASIR
2
y9
8.5
482.25
906.46
26


 


68
GNTTGSASIR
2
y8
8.5
482.25
792.42
26


 


69
GNTTGSASIR
2
y7
8.5
482.25
691.37
26


 


70
HLLNQR
2
y5
10.2
390.73
643.39
22


 


71
HLLNQR
2
y4
10.2
390.73
530.3
22


 


72
HLLNQR
2
y3
10.2
390.73
417.22
22


 


73
LAALEK
2
y5
11
322.7
531.31
19


 


74
LAALEK
2
y4
11
322.7
460.28
19


 


75
LAALEK
2
y3
11
322.7
389.24
19


 


76
LAELER
2
y5
12.1
365.71
617.33
21


 


77
LAELER
2
y4
12.1
365.71
546.29
21


 


78
LAELER
2
y3
12.1
365.71
417.25
21


 


79
LGVALIDTADNTQVLYR
2
y9
21.4
931.5
1079.6
46


 


80
LGVALIDTADNTQVLYR
2
y8
21.4
931.5
1008.5
46


 


81
LGVALIDTADNTQVLYR
2
y7
21.4
931.5
893.48
46


 


82
LGVALINTADNSQILYR
2
y9
21.1
931.01
1079.6
46


 


83
LGVALINTADNSQILYR
2
y8
21.1
931.01
1008.5
46


 


84
LGVALINTADNSQILYR
2
y7
21.1
931.01
893.48
46


 


85
LIAHLGGPDK
2
y9
12.7
510.8
907.5
27


 


86
LIAHLGGPDK
2
y8
12.7
510.8
794.42
27


 


87
LIAHLGGPDK
2
y7
12.7
510.8
723.38
27


 


88
LIAHVGGPASVTAFAR
2
y9
17.5
783.94
919.5
39


 


89
LIAHVGGPASVTAFAR
2
y8
17.5
783.94
822.45
39


 


90
LIAHVGGPASVTAFAR
2
y7
17.5
783.94
751.41
39


 


91
LIAQLGGPGGVTAFAR
2
y9
19.3
764.44
875.47
39


 


92
LIAQLGGPGGVTAFAR
2
y8
19.3
764.44
778.42
39


 


93
LIAQLGGPGGVTAFAR
2
y7
19.3
764.44
721.4
39


 


94
NLTLGK
2
y5
12.2
323.2
531.35
19


 


95
NLTLGK
2
y4
12.2
323.2
418.27
19


 


96
NLTLGK
2
y3
12.2
323.2
317.22
19


 


97
QLGDETFR
2
y7
14.4
483.24
837.41
26


 


98
QLGDETFR
2
y6
14.4
483.24
724.33
26


 


99
QLGDETFR
2
y5
14.4
483.24
667.3
26


 


100
QLLNQPVEIK
2
y9
16.2
591.35
1053.6
31


 


101
QLLNQPVEIK
2
y8
16.2
591.35
940.55
31


 


102
QLLNQPVEIK
2
y7
16.2
591.35
827.46
31


 


103
QLTLGHALGETQR
2
y9
14.9
712.39
968.49
36


 


104
QLTLGHALGETQR
2
y8
14.9
712.39
911.47
36


 


105
QLTLGHALGETQR
2
y7
14.9
712.39
774.41
36


 


106
QSESDK
2
y5
1.7
347.16
565.25
20


 


107
QSESDK
2
y4
1.7
347.16
478.21
20


 


108
QSESDK
2
y3
1.7
347.16
349.17
20


 


109
QSETQK
2
y5
3.7
360.68
592.29
21


 


110
QSETQK
2
y4
3.7
360.68
505.26
21


 


111
QSETQK
2
y3
3.7
360.68
376.22
21


 


112
QSGGR
2
y4
5.5
252.63
376.19
16


 


113
QSGGR
2
y3
5.5
252.63
289.16
16


 


114
QSGGR
2
b4
5.5
252.63
330.14
16


 


115
SDLVNYNPIAEK
2
y9
17.1
681.85
1047.6
35


 


116
SDLVNYNPIAEK
2
y8
17.1
681.85
948.48
35


 


117
SDLVNYNPIAEK
2
y7
17.1
681.85
834.44
35


 


118
SESEPNLLNQR
2
y9
13.3
643.82
1070.6
33


 


119
SESEPNLLNQR
2
y8
13.3
643.82
983.53
33


 


120
SESEPNLLNQR
2
y7
13.3
643.82
854.48
33


 


121
SLGDETFR
2
y7
14.6
462.72
837.41
25


 


122
SLGDETFR
2
y6
14.6
462.72
724.33
25


 


123
SLGDETFR
2
y5
14.6
462.72
667.3
25


 


124
SSGGR
2
y4
5.9
232.12
376.19
15


 


125
SSGGR
2
y3
5.9
232.12
289.16
15


 


126
SWVVGDK
2
y6
14.2
395.71
703.38
22


 


127
SWVVGDK
2
y5
14.2
395.71
517.3
22


 


128
SWVVGDK
2
y4
14.2
395.71
418.23
22


 


129
TEPTLNTAIPGDPR
2
y9
15.6
741.38
940.48
38


 


130
TEPTLNTAIPGDPR
2
y8
15.6
741.38
826.44
38


 


131
TEPTLNTAIPGDPR
2
y7
15.6
741.38
725.39
38


 


132
TGSGDYGTTNDIAVIWPK
2
y8
19.9
947.96
941.55
47


 


133
TGSGDYGTTNDIAVIWPK
2
y7
19.9
947.96
826.52
47


 


134
TGSGDYGTTNDIAVIWPK
2
y6
19.9
947.96
713.43
47


 


135
TGSGDYGTTNDIAVIWPQGR
3
y9
19.7
703.34
1039.6
39


 


136
TGSGDYGTTNDIAVIWPQGR
3
y8
19.7
703.34
926.52
39


 


137
TGSGDYGTTNDIAVIWPQGR
3
y7
19.7
703.34
855.48
39


 


138
TGSGGYGTTNDIAVIWPK
2
y9
19.5
918.96
1055.6
45


 


139
TGSGGYGTTNDIAVIWPK
2
y8
19.5
918.96
941.55
45


 


140
TGSGGYGTTNDIAVIWPK
2
y7
19.5
918.96
826.52
45


 


141
VMAAAAVLK
2
y8
15.3
437.26
774.45
24


 


142
VMAAAAVLK
2
y7
15.3
437.26
643.41
24


 


143
VMAAAAVLK
2
y6
15.3
437.26
572.38
24


 


144
VMAVAAVLK
2
y8
16.3
451.28
802.49
25


 


145
VMAVAAVLK
2
y7
16.3
451.28
671.45
25


 


146
VMAVAAVLK
2
y6
16.3
451.28
600.41
25


 


147
VTAFAR
2
y5
11.6
332.69
565.31
20


 


148
VTAFAR
2
y4
11.6
332.69
464.26
20


 


149
VTAFAR
2
y3
11.6
332.69
393.22
20









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the 3 transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 9
Identification of a Resistance to SHV Beta-Lactams
The samples corresponding to a species able to comprise an SHV resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 8 instead of the peptides from TABLE 3.














TABLE 8







Charge
first-








state
generation
Retention
(m/z)
(m/z)
Collision


Transition

of the
fragment
time
filtered
filtered
energy


number
Peptide
precursor
ion
(minutes)
in Q1
in Q3
(eV)






















1
AGAGER
2
y5
5
280.64
489.24
17


 


2
AGAGER
2
y4
5
280.64
432.22
17


 


3
AGAGER
2
y3
5
280.64
361.18
17


 


4
ATTTPASMAATLR
2
y9
15.1
646.34
917.49
33


 


5
ATTTPASMAATLR
2
y8
15.1
646.34
820.43
33


 


6
ATTTPASMAATLR
2
y7
15.1
646.34
749.4
33


 


7
CIISLLATLPLAVHASPQPLEQIK
3
y9
27.3
871.5
1039.6
48


 


8
CIISLLATLPLAVHASPQPLEQIK
3
y8
27.3
871.5
952.55
48


 


9
CIISLLATLPLAVHASPQPLEQIK
3
y7
27.3
871.5
855.49
48


 


10
DMPASMAER
2
y8
12
504.22
892.4
27


 


11
DMPASMAER
2
y7
12
504.22
761.36
27


 


12
DMPASMAER
2
y6
12
504.22
664.31
27


 


13
DSPASMAER
2
y8
8.8
482.21
848.39
26


 


14
DSPASMAER
2
y7
8.8
482.21
761.36
26


 


15
DSPASMAER
2
y6
8.8
482.21
664.31
26


 


16
DTLASMAER
2
y8
13.3
497.24
878.44
27


 


17
DTLASMAER
2
y7
13.3
497.24
777.39
27


 


18
DTLASMAER
2
y6
13.3
497.24
664.31
27


 


19
DTPASMAER
2
y8
9.2
489.22
862.41
27


 


20
DTPASMAER
2
y7
9.2
489.22
761.36
27


 


21
DTPASMAER
2
y6
9.2
489.22
664.31
27


 


22
DTPASMAK
2
y7
8.5
410.7
705.36
23


 


23
DTPASMAK
2
y6
8.5
410.7
604.31
23


 


24
DTPASMAK
2
y5
8.5
410.7
507.26
23


 


25
DTTTPASMAATLR
2
y9
15.2
668.33
917.49
34


 


26
DTTTPASMAATLR
2
y8
15.2
668.33
820.43
34


 


27
DTTTPASMAATLR
2
y7
15.2
668.33
749.4
34


 


28
DTTTPASMAGTLR
2
y9
15.1
661.32
903.47
34


 


29
DTTTPASMAGTLR
2
y8
15.1
661.32
806.42
34


 


30
DTTTPASMAGTLR
2
y7
15.1
661.32
735.38
34


 


31
DTTTPASMTATLR
2
y9
14.9
683.34
947.5
35


 


32
DTTTPASMTATLR
2
y8
14.9
683.34
850.45
35


 


33
DTTTPASMTATLR
2
y7
14.9
683.34
779.41
35


 


34
FPMISTFK
2
y7
19.7
485.76
823.44
26


 


35
FPMISTFK
2
y6
19.7
485.76
726.39
26


 


36
FPMISTFK
2
y5
19.7
485.76
595.34
26


 


37
FPMMSTFK
2
y7
19.3
494.74
841.39
27


 


38
FPMMSTFK
2
y6
19.3
494.74
744.34
27


 


39
FPMMSTFK
2
y5
19.3
494.74
613.3
27


 


40
GIVALLGGNIK
2
y9
18.4
527.83
884.56
28


 


41
GIVALLGGNIK
2
y8
18.4
527.83
785.49
28


 


42
GIVALLGGNIK
2
y7
18.4
527.83
714.45
28


 


43
GIVALLGPDNK
2
y8
16.9
548.82
827.46
29


 


44
GIVALLGPDNK
2
y7
16.9
548.82
756.43
29


 


45
GIVALLGPDNK
2
y6
16.9
548.82
643.34
29


 


46
GIVALLGPNHK
2
y9
16.3
559.84
948.56
30


 


47
GIVALLGPNHK
2
y8
16.3
559.84
849.49
30


 


48
GIVALLGPNHK
2
y7
16.3
559.84
778.46
30


 


49
GIVALLGPNNK
2
y9
16.5
548.33
925.55
29


 


50
GIVALLGPNNK
2
y8
16.5
548.33
826.48
29


 


51
GIVALLGPNNK
2
y7
16.5
548.33
755.44
29


 


52
GIVALLGPNNNAER
2
y9
16.4
719.39
984.49
37


 


53
GIVALLGPNNNAER
2
y8
16.4
719.39
871.4
37


 


54
GIVALLGPNNNAER
2
y7
16.4
719.39
814.38
37


 


55
GIVALR
2
y5
14.2
314.71
571.39
19


 


56
GIVALR
2
y4
14.2
314.71
458.31
19


 


57
GIVALR
2
y3
14.2
314.71
359.24
19


 


58
GPNNK
2
y4
5.3
265.14
472.25
17


 


59
GPNNK
2
y3
5.3
265.14
375.2
17


 


60
GPNNK
2
b4
5.3
265.14
383.17
17


 


61
GTTTPASMAATLR
2
y9
15.3
639.33
917.49
33


 


62
GTTTPASMAATLR
2
y8
15.3
639.33
820.43
33


 


63
GTTTPASMAATLR
2
y7
15.3
639.33
749.4
33


 


64
HLADGMTVGELCAAAITMSDNSAAK
3
y9
20
845.39
924.41
46


 


65
HLADGMTVGELCAAAITMSDNSAAK
3
y8
20
845.39
823.36
46


 


66
HLADGMTVGELCAAAITMSDNSAAK
3
y7
20
845.39
692.32
46


 


67
HLLQWMVDDR
2
y9
21.2
656.83
1175.6
34


 


68
HLLQWMVDDR
2
y8
21.2
656.83
1062.5
34


 


69
HLLQWMVDDR
2
y7
21.2
656.83
949.42
34


 


70
IHYLQQDLVDYSPVSEK
3
y9
19.9
678.68
1023.5
38


 


71
IHYLQQDLVDYSPVSEK
3
y8
19.9
678.68
924.43
38


 


72
IHYLQQDLVDYSPVSEK
3
y7
19.9
678.68
809.4
38


 


73
IVVIYLR
2
y6
19.1
438.29
762.49
24


 


74
IVVIYLR
2
y5
19.1
438.29
663.42
24


 


75
IVVIYLR
2
y4
19.1
438.29
564.35
24


 


76
LCIISLLAALPLAVHASPQPLEQIK
3
y9
29.8
899.19
1039.6
49


 


77
LCIISLLAALPLAVHASPQPLEQIK
3
y8
29.8
899.19
952.55
49


 


78
LCIISLLAALPLAVHASPQPLEQIK
3
y7
29.8
899.19
855.49
49


 


79
LCIISLLATLPLAVHASPQPLDQIK
3
y9
29.5
904.52
1025.6
49


 


80
LCIISLLATLPLAVHASPQPLDQIK
3
y8
29.5
904.52
938.53
49


 


81
LCIISLLATLPLAVHASPQPLDQIK
3
y7
29.5
904.52
841.48
49


 


82
LCIISLLATLPLAVHASPQPLEQIK
3
y9
29.6
909.19
1039.6
49


 


83
LCIISLLATLPLAVHASPQPLEQIK
3
y8
29.6
909.19
952.55
49


 


84
LCIISLLATLPLAVHASPQPLEQIK
3
y7
29.6
909.19
855.49
49


 


85
LCIISLLATLPLAVHSSPQPLEQIK
3
y9
29.3
914.53
1039.6
50


 


86
LCIISLLATLPLAVHSSPQPLEQIK
3
y8
29.3
914.53
952.55
50


 


87
LCIISLLATLPLAVHSSPQPLEQIK
3
y7
29.3
914.53
855.49
50


 


88
LCIISLLATLPLAVHTSPQPLEQIK
3
y9
29.5
919.2
1039.6
50


 


89
LCIISLLATLPLAVHTSPQPLEQIK
3
y8
29.5
919.2
952.55
50


 


90
LCIISLLATLPLAVHTSPQPLEQIK
3
y7
29.5
919.2
855.49
50


 


91
LCIISLLATLPLTVHASPQPLEQIK
3
y9
29.3
919.2
1039.6
50


 


92
LCIISLLATLPLTVHASPQPLEQIK
3
y8
29.3
919.2
952.55
50


 


93
LCIISLLATLPLTVHASPQPLEQIK
3
y7
29.3
919.2
855.49
50


 


94
LCIISLLATLPLVVHASPQPLEQIK
3
y9
30.3
918.54
1039.6
50


 


95
LCIISLLATLPLVVHASPQPLEQIK
3
y8
30.3
918.54
952.55
50


 


96
LCIISLLATLPLVVHASPQPLEQIK
3
y7
30.3
918.54
855.49
50


 


97
LCIISLLATLSLAVHASPQPLEQIK
3
y9
29.5
905.85
1039.6
49


 


98
LCIISLLATLSLAVHASPQPLEQIK
3
y8
29.5
905.85
952.55
49


 


99
LCIISLLATLSLAVHASPQPLEQIK
3
y7
29.5
905.85
855.49
49


 


100
LCIISLLATMPLAVHASPQPLEQIK
3
y9
27.4
915.18
1039.6
50


 


101
LCIISLLATMPLAVHASPQPLEQIK
3
y8
27.4
915.18
952.55
50


 


102
LCIISLLATMPLAVHASPQPLEQIK
3
y7
27.4
915.18
855.49
50


 


103
LCIISLLAVLPLAVHASPQPLEQIK
3
y9
30.5
908.53
1039.6
49


 


104
LCIISLLAVLPLAVHASPQPLEQIK
3
y8
30.5
908.53
952.55
49


 


105
LCIISLLAVLPLAVHASPQPLEQIK
3
y7
30.5
908.53
855.49
49


 


106
LLISQR
2
y5
12.9
365.23
616.38
21


 


107
LLISQR
2
y4
12.9
365.23
503.29
21


 


108
LLISQR
2
y3
12.9
365.23
390.21
21


 


109
LLLATVGGPAGLTAFLR
2
y9
24
835.5
945.55
42


 


110
LLLATVGGPAGLTAFLR
2
y8
24
835.5
848.5
42


 


111
LLLATVGGPAGLTAFLR
2
y7
24
835.5
777.46
42


 


112
LLNSQR
2
y5
9.4
365.71
617.34
21


 


113
LLNSQR
2
y4
9.4
365.71
504.25
21


 


114
LLNSQR
2
y3
9.4
365.71
390.21
21


 


115
LLTNQR
2
y5
9.8
372.72
631.35
21


 


116
LLTNQR
2
y4
9.8
372.72
518.27
21


 


117
LLTNQR
2
y3
9.8
372.72
417.22
21


 


118
LLTSQR
2
y5
9.8
359.22
604.34
21


 


119
LLTSQR
2
y4
9.8
359.22
491.26
21


 


120
LLTSQR
2
y3
9.8
359.22
390.21
21


 


121
LNIISLLATLPLAVHASPQPLEQIK
3
y9
29.6
893.87
1039.6
49


 


122
LNIISLLATLPLAVHASPQPLEQIK
3
y8
29.6
893.87
952.55
49


 


123
LNIISLLATLPLAVHASPQPLEQIK
3
y7
29.6
893.87
855.49
49


 


124
LSASSQR
2
y6
6.2
374.7
635.31
21


 


125
LSASSQR
2
y5
6.2
374.7
548.28
21


 


126
LSASSQR
2
y4
6.2
374.7
477.24
21


 


127
LSESQLSGR
2
y8
10.5
488.76
863.42
27


 


128
LSESQLSGR
2
y7
10.5
488.76
776.39
27


 


129
LSESQLSGR
2
y6
10.5
488.76
647.35
27


 


130
LSESQLSGSVGMIEMDLASGR
3
y9
21.1
723.02
991.49
40


 


131
LSESQLSGSVGMIEMDLASGR
3
y8
21.1
723.02
878.4
40


 


132
LSESQLSGSVGMIEMDLASGR
3
y7
21.1
723.02
749.36
40


 


133
MVVIYLR
2
y6
18.9
447.27
762.49
25


 


134
MVVIYLR
2
y5
18.9
447.27
663.42
25


 


135
MVVIYLR
2
y4
18.9
447.27
564.35
25


 


136
NEALPGDAR
2
y8
10.6
471.74
828.42
26


 


137
NEALPGDAR
2
y7
10.6
471.74
699.38
26


 


138
NEALPGDAR
2
y6
10.6
471.74
628.34
26


 


139
NQHIAGIGAALIEHWQR
2
y9
21.2
957.51
1123.6
47


 


140
NQHIAGIGAALIEHWQR
2
y8
21.2
957.51
1052.6
47


 


141
NQHIAGIGAALIEHWQR
2
y7
21.2
957.51
981.53
47


 


142
NQQIAGIGAALIEHWQR
2
y9
22.1
953.01
1123.6
47


 


143
NQQIAGIGAALIEHWQR
2
y8
22.1
953.01
1052.6
47


 


144
NQQIAGIGAALIEHWQR
2
y7
22.1
953.01
981.53
47


 


145
NQQIAGLGAALIEHWQR
2
y9
22.3
953.01
1123.6
47


 


146
NQQIAGLGAALIEHWQR
2
y8
22.3
953.01
1052.6
47


 


147
NQQIAGLGAALIEHWQR
2
y7
22.3
953.01
981.53
47


 


148
NTTTPASMAATLR
2
y9
15.3
667.84
917.49
34


 


149
NTTTPASMAATLR
2
y8
15.3
667.84
820.43
34


 


150
NTTTPASMAATLR
2
y7
15.3
667.84
749.4
34


 


151
NVLTSQR
2
y6
9.6
409.23
703.41
23


 


152
NVLTSQR
2
y5
9.6
409.23
604.34
23


 


153
NVLTSQR
2
y4
9.6
409.23
491.26
23


 


154
QIDDNVTR
2
y7
9.4
480.74
832.42
26


 


155
QIDDNVTR
2
y6
9.4
480.74
719.33
26


 


156
QIDDNVTR
2
y5
9.4
480.74
604.3
26


 


157
QIGDK
2
y4
5.8
280.66
432.25
17


 


158
QIGDK
2
y3
5.8
280.66
319.16
17


 


159
QIGDK
2
b4
5.8
280.66
414.2
17


 


160
QIGDNVTR
2
y7
9.5
451.74
774.41
25


 


161
QIGDNVTR
2
y6
9.5
451.74
661.33
25


 


162
QIGDNVTR
2
y5
9.5
451.74
604.3
25


 


163
QIGENVTR
2
y7
9.5
458.75
788.43
25


 


164
QIGENVTR
2
y6
9.5
458.75
675.34
25


 


165
QIGENVTR
2
y5
9.5
458.75
618.32
25


 


166
QLLQWMVDAR
2
y9
21.5
630.33
1131.6
33


 


167
QLLQWMVDAR
2
y8
21.5
630.33
1018.5
33


 


168
QLLQWMVDAR
2
y7
21.5
630.33
905.43
33


 


169
QLLQWMVDDGVAGPLIR
2
y9
25
956.01
897.52
47


 


170
QLLQWMVDDGVAGPLIR
2
y8
25
956.01
782.49
47


 


171
QLLQWMVDDGVAGPLIR
2
y7
25
956.01
725.47
47


 


172
QLLQWMVDDR
2
y9
21.7
652.33
1175.6
34


 


173
QLLQWMVDDR
2
y8
21.7
652.33
1062.5
34


 


174
QLLQWMVDDR
2
y7
21.7
652.33
949.42
34


 


175
QLLQWMVDGR
2
y8
21.3
623.32
1004.5
32


 


176
QLLQWMVDGR
2
y7
21.3
623.32
891.41
32


 


177
QLLQWMVDGR
2
y6
21.3
623.32
763.36
32


 


178
QLLQWMVEDR
2
y9
21.9
659.33
1189.6
34


 


179
QLLQWMVEDR
2
y8
21.9
659.33
1076.5
34


 


180
QLLQWMVEDR
2
y7
21.9
659.33
963.44
34


 


181
QQDLVDYSPVSEK
2
y9
15.6
754.37
1023.5
38


 


182
QQDLVDYSPVSEK
2
y8
15.6
754.37
924.43
38


 


183
QQDLVDYSPVSEK
2
y7
15.6
754.37
809.4
38


 


184
QQHLVDYSPVSEK
2
y9
13.9
765.38
1023.5
39


 


185
QQHLVDYSPVSEK
2
y8
13.9
765.38
924.43
39


 


186
QQHLVDYSPVSEK
2
y7
13.9
765.38
809.4
39


 


187
QSESQLSGR
2
y8
7.6
496.24
863.42
27


 


188
QSESQLSGR
2
y7
7.6
496.24
776.39
27


 


189
QSESQLSGR
2
y6
7.6
496.24
647.35
27


 


190
QSESQLSGSVGMIEMDLASGR
3
y9
19.7
728.01
991.49
40


 


191
QSESQLSGSVGMIEMDLASGR
3
y8
19.7
728.01
878.4
40


 


192
QSESQLSGSVGMIEMDLASGR
3
y7
19.7
728.01
749.36
40


 


193
SQLQLLQWMVDDR
2
y9
26.3
816.41
1175.6
41


 


194
SQLQLLQWMVDDR
2
y8
26.3
816.41
1062.5
41


 


195
SQLQLLQWMVDDR
2
y7
26.3
816.41
949.42
41


 


196
SVLPAGWFIADK
2
y9
22.9
652.36
1004.5
34


 


197
SVLPAGWFIADK
2
y8
22.9
652.36
907.47
34


 


198
SVLPAGWFIADK
2
y7
22.9
652.36
836.43
34


 


199
SVLPAGWFIADR
2
y9
23
666.36
1032.5
34


 


200
SVLPAGWFIADR
2
y8
23
666.36
935.47
34


 


201
SVLPAGWFIADR
2
y7
23
666.36
864.44
34


 


202
SVLSAGWFIADK
2
y9
22.7
647.35
994.5
33


 


203
SVLSAGWFIADK
2
y8
22.7
647.35
907.47
33


 


204
SVLSAGWFIADK
2
y7
22.7
647.35
836.43
33


 


205
TGAAER
2
y5
4.8
302.66
503.26
18


 


206
TGAAER
2
y4
4.8
302.66
446.24
18


 


207
TGAAER
2
y3
4.8
302.66
375.2
18


 


208
TGAAK
2
y4
6
224.13
346.21
15


 


209
TGAAK
2
y3
6
224.13
289.19
15


 


210
TGAAK
2
b4
6
224.13
301.15
15


 


211
TGAGER
2
y5
4.9
295.65
489.24
18


 


212
TGAGER
2
y4
4.9
295.65
432.22
18


 


213
TGAGER
2
y3
4.9
295.65
361.18
18


 


214
TGAGK
2
y4
6.1
217.12
332.19
15


 


215
TGAGK
2
y3
6.1
217.12
275.17
15


 


216
TGAGK
2
b4
6.1
217.12
287.13
15


 


217
TGASER
2
y5
4.5
310.65
519.25
19


 


218
TGASER
2
y4
4.5
310.65
462.23
19


 


219
TGASER
2
y3
4.5
310.65
391.19
19


 


220
TGASK
2
y4
5.8
232.13
362.2
15


 


221
TGASK
2
y3
5.8
232.13
305.18
15


 


222
TGASK
2
b4
5.8
232.13
317.15
15


 


223
TGASR
2
y4
5.8
246.13
390.21
16


 


224
TGASR
2
y3
5.8
246.13
333.19
16


 


225
TGASR
2
y2
5.8
246.13
262.15
16


 


226
TLTAWCADER
2
y9
15.9
611.78
1121.5
32


 


227
TLTAWCADER
2
y8
15.9
611.78
1008.4
32


 


228
TLTAWCADER
2
y7
15.9
611.78
907.37
32


 


229
TLTAWHADER
2
y9
14.4
600.29
1098.5
31


 


230
TLTAWHADER
2
y8
14.4
600.29
985.45
31


 


231
TLTAWHADER
2
y7
14.4
600.29
884.4
31


 


232
TLTAWR
2
y5
15
374.21
646.37
21


 


233
TLTAWR
2
y4
15
374.21
533.28
21


 


234
TLTAWR
2
y3
15
374.21
432.24
21


 


235
TVGGPAGLTAFLR
2
y9
19.7
630.36
945.55
33


 


236
TVGGPAGLTAFLR
2
y8
19.7
630.36
848.5
33


 


237
TVGGPAGLTAFLR
2
y7
19.7
630.36
777.46
33


 


238
TVVIYLR
2
y6
17.4
432.27
762.49
24


 


239
TVVIYLR
2
y5
17.4
432.27
663.42
24


 


240
TVVIYLR
2
y4
17.4
432.27
564.35
24


 


241
VAGPLIR
2
y6
14.1
363.24
626.4
21


 


242
VAGPLIR
2
y5
14.1
363.24
555.36
21


 


243
VAGPLIR
2
y4
14.1
363.24
498.34
21


 


244
VALCGAVLAR
2
y9
17.2
515.3
930.52
28


 


245
VALCGAVLAR
2
y8
17.2
515.3
859.48
28


 


246
VALCGAVLAR
2
y7
17.2
515.3
746.4
28


 


247
VDAGDEQLER
2
y9
10.9
566.27
1032.5
30


 


248
VDAGDEQLER
2
y8
10.9
566.27
917.43
30


 


249
VDAGDEQLER
2
y7
10.9
566.27
846.4
30


 


250
VDAGDK
2
y5
4.1
302.65
505.23
18


 


251
VDAGDK
2
y4
4.1
302.65
390.2
18


 


252
VDAGDK
2
y3
4.1
302.65
319.16
18


 


253
VGMIEMDLASGR
2
y9
18.7
639.81
991.49
33


 


254
VGMIEMDLASGR
2
y8
18.7
639.81
878.4
33


 


255
VGMIEMDLASGR
2
y7
18.7
639.81
749.36
33


 


256
VGMIEMDLASR
2
y9
18.7
611.3
1065.5
32


 


257
VGMIEMDLASR
2
y8
18.7
611.3
934.47
32


 


258
VGMIEMDLASR
2
y7
18.7
611.3
821.38
32


 


259
VGMIEMDLASSR
2
y9
18.4
654.82
1021.5
34


 


260
VGMIEMDLASSR
2
y8
18.4
654.82
908.41
34


 


261
VGMIEMDLASSR
2
y7
18.4
654.82
779.37
34


 


262
VLLCGAVLAR
2
y9
19.3
536.32
972.57
29


 


263
VLLCGAVLAR
2
y8
19.3
536.32
859.48
29


 


264
VLLCGAVLAR
2
y7
19.3
536.32
746.4
29


 


265
VVLCGAMLAR
2
y8
18.1
545.3
891.45
29


 


266
VVLCGAMLAR
2
y7
18.1
545.3
778.37
29


 


267
VVLCGAMLAR
2
y6
18.1
545.3
618.34
29


 


268
VVLCGAVLAR
2
y9
18
529.31
958.55
28


 


269
VVLCGAVLAR
2
y8
18
529.31
859.48
28


 


270
VVLCGAVLAR
2
y7
18
529.31
746.4
28


 


271
VVLCGTVLAR
2
y9
16.6
544.32
988.56
29


 


272
VVLCGTVLAR
2
y8
16.6
544.32
889.49
29


 


273
VVLCGTVLAR
2
y7
16.6
544.32
776.41
29


 


274
WETDR
2
y4
9.8
353.66
520.24
21


 


275
WETDR
2
y3
9.8
353.66
391.19
21


 


276
WETDR
2
b4
9.8
353.66
532.2
21


 


277
WETELNEAFPGDAR
2
y9
19
817.88
976.45
41


 


278
WETELNEAFPGDAR
2
y8
19
817.88
862.41
41


 


279
WETELNEAFPGDAR
2
y7
19
817.88
733.36
41


 


280
WETELNEALPADAR
2
y9
18.9
807.89
956.48
41


 


281
WETELNEALPADAR
2
y8
18.9
807.89
842.44
41


 


282
WETELNEALPADAR
2
y7
18.9
807.89
713.39
41


 


283
WETELNEALPGDAR
2
y9
18.5
800.88
942.46
40


 


284
WETELNEALPGDAR
2
y8
18.5
800.88
828.42
40


 


285
WETELNEALPGDAR
2
y7
18.5
800.88
699.38
40


 


286
WETELNEALSGDAR
2
y9
18
795.87
932.44
40


 


287
WETELNEALSGDAR
2
y8
18
795.87
818.4
40


 


288
WETELNEALSGDAR
2
y7
18
795.87
689.36
40


 


289
WETELNEVLPGDAR
2
y9
19.4
814.9
970.5
41


 


290
WETELNEVLPGDAR
2
y8
19.4
814.9
856.45
41


 


291
WETELNEVLPGDAR
2
y7
19.4
814.9
727.41
41


 


292
WETER
2
y4
10.4
360.67
534.25
21


 


293
WETER
2
y3
10.4
360.67
405.21
21


 


294
WETER
2
b4
10.4
360.67
546.22
21









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the 3 transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 10
Identification of a Resistance to FOX Beta-Lactams
The samples corresponding to a species able to comprise a FOX resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 9 instead of the peptides from TABLE 3.














TABLE 9







Charge
first-
Retention
(m/z)
(m/z)
Collision


Transition

state of the
generation
time
filtered
filtered in
energy


number
Peptide
precursor
fragment ion
(minutes)
in Q1
Q3
(eV)






















1
AHYFNYGVANR
2
y9
15.5
656.32
1103.53
34


 


2
AHYFNYGVANR
2
y8
15.5
656.32
940.46
34


 


3
AHYFNYGVANR
2
y7
15.5
656.32
793.4
34


 


4
AMGEQR
2
y5
5.3
346.16
620.28
20


 


5
AMGEQR
2
y4
5.3
346.16
489.24
20


 


6
AMGEQR
2
y3
5.3
346.16
432.22
20


 


7
ESGQR
2
y4
4.3
288.64
447.23
18


 


8
ESGQR
2
y3
4.3
288.64
360.2
18


 


9
ESGQR
2
b4
4.3
288.64
402.16
18


 


10
FAVPK
2
y4
11.3
281.17
414.27
17


 


11
FAVPK
2
y3
11.3
281.17
343.23
17


 


12
FAVPK
2
b4
11.3
281.17
415.23
17


 


13
GGFELDDK
2
y7
14.5
440.71
823.38
24


 


14
GGFELDDK
2
y6
14.5
440.71
766.36
24


 


15
GGFELDDK
2
y5
14.5
440.71
619.29
24


 


16
GIAIVMLANR
2
y9
19.3
529.31
1000.6
28


 


17
GIAIVMLANR
2
y8
19.3
529.31
887.51
28


 


18
GIAIVMLANR
2
y7
19.3
529.31
816.48
28


 


19
IPGMAVAVLK
2
y9
18.1
499.81
885.52
27


 


20
IPGMAVAVLK
2
y8
18.1
499.81
788.47
27


 


21
IPGMAVAVLK
2
y7
18.1
499.81
731.45
27


 


22
NYPIEAR
2
y6
12.2
431.72
748.4
24


 


23
NYPIEAR
2
y5
12.2
431.72
585.34
24


 


24
NYPIEAR
2
y4
12.2
431.72
488.28
24


 


25
SWSPVYPAGTHR
2
y9
15.5
679.34
997.52
35


 


26
SWSPVYPAGTHR
2
y8
15.5
679.34
900.47
35


 


27
SWSPVYPAGTHR
2
y7
15.5
679.34
801.4
35


 


28
TGSADLLK
2
y7
14
402.73
703.4
23


 


29
TGSADLLK
2
y6
14
402.73
646.38
23


 


30
TGSADLLK
2
y5
14
402.73
559.34
23


 


31
TGSTGGFGAYVAFVPAR
2
y9
19.5
829.42
993.55
41


 


32
TGSTGGFGAYVAFVPAR
2
y8
19.5
829.42
922.51
41


 


33
TGSTGGFGAYVAFVPAR
2
y7
19.5
829.42
759.45
41


 


34
TLTATLGAYAAVK
2
y9
17.2
640.37
893.51
33


 


35
TLTATLGAYAAVK
2
y8
17.2
640.37
792.46
33


 


36
TLTATLGAYAAVK
2
y7
17.2
640.37
679.38
33


 


37
VSEQTLFEIGSVSK
2
y9
19.6
762.4
979.55
39


 


38
VSEQTLFEIGSVSK
2
y8
19.6
762.4
866.46
39


 


39
VSEQTLFEIGSVSK
2
y7
19.6
762.4
719.39
39


 


40
VSQHAPWLK
2
y8
15.3
533.3
966.52
28


 


41
VSQHAPWLK
2
y7
15.3
533.3
879.48
28


 


42
VSQHAPWLK
2
y6
15.3
533.3
751.42
28


 


43
VTPGVLAAEAYGIK
2
y9
18.4
694.89
935.52
36


 


44
VTPGVLAAEAYGIK
2
y8
18.4
694.89
822.44
36


 


45
VTPGVLAAEAYGIK
2
y7
18.4
694.89
751.4
36









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 11
Identification of a Resistance to TEM or CTX-M Beta-Lactams
The samples corresponding to a species able to comprise a TEM or CTX-M resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 10 instead of the peptides from TABLE 3.












TABLE 10









Charge state



Transition


First-generation
of the
Clinical


number
Protein
Peptide
fragment ion
precursor
interest




















1
CTX-M
AMAQTLR
y4 monocharged
2
2be


 


2
CTX-M
AMAQTLR
y5 monocharged
2
2be


 


3
CTX-M
AMAQTLR
y6 monocharged
2
2be


 


4
CTX-M
AQLVTWLK
y5 monocharged
2
2be


 


5
CTX-M
AQLVTWLK
y6 monocharged
2
2be


 


6
CTX-M
AQLVTWLK
y7 monocharged
2
2be


 


7
CTX-M
FAMCSTSK
y5 monocharged
2
2be


 


8
CTX-M
FAMCSTSK
y6 monocharged
2
2be


 


9
CTX-M
FAMCSTSK
y7 monocharged
2
2be


 


10
CTX-M
LAALEK
y3 monocharged
2
2be


 


11
CTX-M
LAALEK
y4 monocharged
2
2be


 


12
CTX-M
LAALEK
y5 monocharged
2
2be


 


13
CTX-M
LGVALINTADNSQILYR
y7 monocharged
2
2be


 


14
CTX-M
LGVALINTADNSQILYR
y8 monocharged
2
2be


 


15
CTX-M
LGVALINTADNSQILYR
y9 monocharged
2
2be


 


16
CTX-M
NLTLGK
y3 monocharged
2
2be


 


17
CTX-M
NLTLGK
y4 monocharged
2
2be


 


18
CTX-M
NLTLGK
y5 monocharged
2
2be


 


19
CTX-M
QSETQK
y3 monocharged
2
2be


 


20
CTX-M
QSETQK
y4 monocharged
2
2be


 


21
CTX-M
QSETQK
y5 monocharged
2
2be


 


22
CTX-M
SDLVNYNPIAEK
y7 monocharged
2
2be


 


23
CTX-M
SDLVNYNPIAEK
y8 monocharged
2
2be


 


24
CTX-M
SDLVNYNPIAEK
y9 monocharged
2
2be


 


25
CTX-M
TEPTLNTAIPGDPR
y7 monocharged
2
2be


 


26
CTX-M
TEPTLNTAIPGDPR
y8 monocharged
2
2be


 


27
CTX-M
TEPTLNTAIPGDPR
y9 monocharged
2
2be


 


28
CTX-M
VMAAAAVLK
y6 monocharged
2
2be


 


29
CTX-M
VMAAAAVLK
y7 monocharged
2
2be


 


30
CTX-M
VMAAAAVLK
y8 monocharged
2
2be


 


31
TEM
DAEDQLGAR
y5 monocharged
2
TEM


 


32
TEM
DAEDQLGAR
y6 monocharged
2
TEM


 


33
TEM
DAEDQLGAR
y7 monocharged
2
TEM


 


34
TEM
DTTMPAAMATTLR
y7 monocharged
2
TEM


 


35
TEM
DTTMPAAMATTLR
y8 monocharged
2
TEM


 


36
TEM
DTTMPAAMATTLR
y9 monocharged
2
TEM


 


37
TEM
DTTTPAAMATTLR
y7 monocharged
2
TEM


 


38
TEM
DTTTPAAMATTLR
y9 dicharged
2
TEM


 


39
TEM
DTTTPAAMATTLR
y9 monocharged
2
TEM


 


40
TEM
EPELNEAIPNDER
y5 monocharged
2
TEM


 


41
TEM
EPELNEAIPNDER
y7 monocharged
2
TEM


 


42
TEM
EPELNEAIPNDER
y8 monocharged
2
TEM


 


43
TEM
GIIAALGPDGKPSR
y7 monocharged
2
TEM


 


44
TEM
GIIAALGPDGKPSR
y8 monocharged
2
TEM


 


45
TEM
GIIAALGPDGKPSR
y9 monocharged
2
TEM


 


46
TEM
GSCGIIAALGPDGKPSR
y7 monocharged
2
2br


 


47
TEM
GSCGIIAALGPDGKPSR
y8 monocharged
2
2br


 


48
TEM
GSCGIIAALGPDGKPSR
y9 monocharged
2
2br


 


49
TEM
GSSGIIAALGPDGKPSR
y7 monocharged
2
TEM


 


50
TEM
GSSGIIAALGPDGKPSR
y8 monocharged
2
TEM


 


51
TEM
GSSGIIAALGPDGKPSR
y9 monocharged
2
TEM


 


52
TEM
HLTDGMTVR
y4 monocharged
2
TEM


 


53
TEM
HLTDGMTVR
y7 monocharged
2
TEM


 


54
TEM
HLTDGMTVR
y8 monocharged
2
TEM


 


55
TEM
IHYSQNDLVEYSPVTEK
y6 monocharged
3
TEM


 


56
TEM
IHYSQNDLVEYSPVTEK
y7 monocharged
3
TEM


 


57
TEM
IHYSQNDLVEYSPVTEK
y8 monocharged
3
TEM


 


58
TEM
IHYSQNDLVK
y7 monocharged
2
2be


 


59
TEM
IHYSQNDLVK
y8 monocharged
2
2be


 


60
TEM
IHYSQNDLVK
y9 dicharged
2
2be


 


61
TEM
ILESFRPEER
b6 monocharged
2
TEM


 


62
TEM
ILESFRPEER
b8 monocharged
2
TEM


 


63
TEM
ILESFRPEER
y7 dicharged
2
TEM


 


64
TEM
LDHWEPELNEAIPNDER
y5 monocharged
3
2be


 


65
TEM
LDHWEPELNEAIPNDER
y6 monocharged
3
2be


 


66
TEM
LDHWEPELNEAIPNDER
y7 monocharged
3
2be


 


67
TEM
LDSWEPELNEAIPNDER
y5 monocharged
3
2be


 


68
TEM
LDSWEPELNEAIPNDER
y6 monocharged
3
2be


 


69
TEM
LDSWEPELNEAIPNDER
y7 monocharged
3
2be


 


70
TEM
LLTGELLTLASR
y6 monocharged
2
TEM


 


71
TEM
LLTGELLTLASR
y7 monocharged
2
TEM


 


72
TEM
LLTGELLTLASR
y9 monocharged
2
TEM


 


73
TEM
QIAEIGASLIK
y7 monocharged
2
TEM


 


74
TEM
QIAEIGASLIK
y8 monocharged
2
TEM


 


75
TEM
QIAEIGASLIK
y9 monocharged
2
TEM


 


76
TEM
QQLIDWMEADK
y5 monocharged
2
TEM


 


77
TEM
QQLIDWMEADK
y6 monocharged
2
TEM


 


78
TEM
QQLIDWMEADK
y7 monocharged
2
TEM


 


79
TEM
VAGPLLR
y4 monocharged
2
TEM


 


80
TEM
VAGPLLR
y5 monocharged
2
TEM


 


81
TEM
VAGPLLR
y6 monocharged
2
TEM


 


82
TEM
VDAGQEQLGR
y5 monocharged
2
TEM


 


83
TEM
VDAGQEQLGR
y7 monocharged
2
TEM


 


84
TEM
VDAGQEQLGR
y8 monocharged
2
TEM


 


85
TEM
VGYIELDLNSGK
y7 monocharged
2
TEM


 


86
TEM
VGYIELDLNSGK
y8 monocharged
2
TEM


 


87
TEM
VGYIELDLNSGK
y9 monocharged
2
TEM


 


88
TEM
WEPELNEAIPNDER
y12 dicharged
2
TEM


 


89
TEM
WEPELNEAIPNDER
y5 monocharged
2
TEM


 


90
TEM
WEPELNEAIPNDER
y7 monocharged
2
TEM


 


91
TEM
YSPVTEK
y4 monocharged
2
2be


 


92
TEM
YSPVTEK
y5 monocharged
2
2be


 


93
TEM
YSPVTEK
y6 monocharged
2
2be









In the clinical interest column, the entries TEM, 2b, 2br, 2be and 2ber correspond to the same meanings as in TABLE 4.
The transitions mentioned in TABLE 10 are detected by using the parameters set out in TABLE 11.












TABLE 11






Retention
(m/z)
(m/z)
Collision



Transition
time
filtered 
filtered 
energy 
Positivity


number
(minutes)
in Q1
in Q3
(eV)
threshold




















1
12.1
395.72
517.31
22
2500


2
12.1
395.72
588.35
22
2500


3
12.1
395.72
719.39
22
2500


4
21
479.79
646.39
26
2500


5
21
479.79
759.48
26
2500


6
21
479.79
887.53
26
2500


7
11.1
466.2
582.26
26
2500


8
11.1
466.2
713.3
26
2500


9
11.1
466.2
784.33
26
2500


10
11
322.7
389.24
19
2500


11
11
322.7
460.28
19
2500


12
11
322.7
531.31
19
2500


13
21.1
931.01
893.48
46
2500


14
21.1
931.01
1008.51
46
2500


15
21.1
931.01
1079.55
46
2500


16
12.2
323.2
317.22
19
2500


17
12.2
323.2
418.27
19
2500


18
12.2
323.2
531.35
19
2500


19
3.7
360.68
376.22
21
2500


20
3.7
360.68
505.26
21
2500


21
3.7
360.68
592.29
21
2500


22
17.1
681.85
834.44
35
2500


23
17.1
681.85
948.48
35
2500


24
17.1
681.85
1047.55
35
2500


25
15.6
741.38
725.39
38
2500


26
15.6
741.38
826.44
38
2500


27
15.6
741.38
940.48
38
2500


28
15.3
437.26
572.38
24
2500


29
15.3
437.26
643.41
24
2500


30
15.3
437.26
774.45
24
2500


31
10.5
487.73
544.32
26
2500


32
10.5
487.73
659.35
26
2500


33
10.5
487.73
788.39
26
2500


34
17.6
690.34
763.61
35
2500


35
17.6
690.34
834.45
35
2500


36
17.6
690.34
931.5
35
2500


37
16.1
675.34
763.41
35
2500


38
16.1
675.34
466.25
35
2500


39
16.1
675.34
931.5
35
2500


40
14.9
763.36
630.28
39
2500


41
14.9
763.36
814.41
39
2500


42
14.9
763.36
943.45
39
2500


43
15.5
676.39
756.4
35
2500


44
15.5
676.39
813.42
35
2500


45
15.5
676.39
926.51
35
2500


46
16.5
828.43
756.4
41
2500


47
16.5
828.43
813.42
41
2500


48
16.5
828.43
926.51
41
2500


49
16.1
791.93
756.4
40
2500


50
16.1
791.93
813.42
40
2500


51
16.1
791.93
926.51
40
2500


52
12
515.26
506.28
28
2500


53
12
515.26
779.37
28
2500


54
12
515.26
892.46
28
2500


55
16.6
674.67
660.36
38
2500


56
16.6
674.67
823.42
38
2500


57
16.6
674.67
952.46
38
2500


58
12.5
608.82
803.43
32
2500


59
12.5
608.82
966.49
32
2500


60
12.5
608.82
552.28
32
2500


61
14.6
638.34
746.42
33
2500


62
14.6
638.34
972.51
33
2500


63
14.6
638.34
460.73
33
2500


64
18
692.99
630.28
39
2500


65
18
692.99
743.37
39
2500


66
18
692.99
814.41
39
2500


67
19.5
676.32
630.28
38
2500


68
19.5
676.32
743.37
38
2500


69
19.5
676.32
814.41
38
2500


70
22.5
643.89
660.4
33
2500


71
22.5
643.89
773.49
33
2500


72
22.5
643.89
959.55
33
2500


73
18.8
571.84
701.46
30
2500


74
18.8
571.84
830.5
30
2500


75
18.8
571.84
901.54
30
2500


76
20.1
688.83
593.26
35
2500


77
20.1
688.83
779.34
35
2500


78
20.1
688.83
894.37
35
2500


79
14.1
363.24
498.34
21
2500


80
14.1
363.24
555.36
21
2500


81
14.1
363.24
626.4
21
2500


82
10.6
536.77
602.38
29
2500


83
10.6
536.77
787.41
29
2500


84
10.6
536.77
858.44
29
2500


85
18.8
654.35
746.4
34
2500


86
18.8
654.35
875.45
34
2500


87
18.8
654.35
988.53
34
2500


88
18
856.4
698.84
43
2500


89
18
856.4
630.28
43
2500


90
18
856.4
814.41
43
2500


91
9.8
412.21
476.27
23
2500


92
9.8
412.21
573.32
23
2500


93
9.8
412.21
660.36
23
2500









When the areas of at least two transitions of the same peptide are greater than or equal to the positivity threshold described in TABLE 11, the detection of the peptide is considered to be positive. When more than two transitions of the same peptide comprise an area less than the positivity threshold described in TABLE 11, the corresponding peptide is considered non-detected.
A sample contains bacteria which express the TEM protein, when at least one peptide corresponding to the TEM resistance mechanism is detected. These bacteria are resistant to penicillins.
A sample contains bacteria which express the TEM protein, phenotype 2b, when at least one peptide corresponding to the TEM resistance mechanism clinical interest 2b is detected. These bacteria are only resistant to penicillins.
A sample contains bacteria which express the TEM protein, phenotype 2br, when at least one peptide corresponding to the TEM resistance mechanism clinical interest 2br is detected. These bacteria are resistant to penicillins associated with an inhibitor of the clavulanic acid and tazobactam type.
A sample contains bacteria which express the CTX-M protein or the TEM protein, phenotype 2be, when at least one peptide corresponding to the CTX-M or TEM resistance mechanism clinical interest 2be is detected. These bacteria are resistant to penicillins, to cephalosporins and to monobactams.
A sample contains bacteria which express the TEM protein, phenotype 2ber, when at least one peptide corresponding to the TEM resistance mechanism clinical interest 2ber, is detected. These bacteria are resistant to penicillins, to cephalosporins and to monobactams, and are insensitive to inhibition by clavulanic acid, sulfobactam or tazobactam.
EXAMPLE 12
Identification of a Resistance to PER Beta-Lactams
Samples Sam74 to Sam78 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 12.










TABLE 12







Names
Species









Ech74
A. baumannii



Ech75
A. baumannii



Ech76
P. aeruginosa



Ech77
P. aeruginosa



Ech78
P. aeruginosa










Samples Sam74 to Sam78 correspond to a species able to comprise a PER resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 13 instead of the peptides from TABLE 3.













TABLE 13







Retention
(m/z)
(m/z)
Collision



Transition

time
filtered
filtered
energy
positivity


number
Peptide
(minutes)
in Q1
in Q3
(eV)
threshold





















1
AAAQLLR
12.91
371.73
401.29
16.9
2000


 


2
AAAQLLR
12.89
371.73
529.35
16.9
2000


 


3
AAAQLLR
12.91
371.73
600.38
16.9
2000


 


4
AAAQVLQK
10.24
414.75
487.32
19.4
2000


 


5
AAAQVLQK
10.24
414.75
615.38
19.4
2000


 


6
AAAQVLQK
10.18
414.75
686.42
19.4
2000


 


7
AAVLQNTWSPMMK
19.35
738.87
506.25
37.9
2000


 


8
AAVLQNTWSPMMK
19.35
738.87
593.28
37.9
2000


 


9
AAVLQNTWSPMMK
19.35
738.87
994.45
37.9
2000


 


10
EQIESIVIGK
17.24
558.32
317.22
27.6
2000


 


11
EQIESIVIGK
17.26
558.32
616.40
27.6
2000


 


12
EQIESIVIGK
17.24
558.32
745.45
27.6
2000


 


13
EQIETIVTGK
15.48
559.31
305.18
27.6
2000


 


14
EQIETIVTGK
15.48
559.31
618.38
27.6
2000


 


15
EQIETIVTGK
15.48
559.31
747.43
27.6
2000


 


16
ETEVVANEAQMHADDQVQYK
14.17
769.02
838.87
30.9
5000


 


17
ETEVVANEAQMHADDQVQYK
14.17
769.02
874.39
30.9
5000


 


18
ETEVVANEAQMHADDQVQYK
14.17
769.02
923.92
30.9
5000


 


19
FPMQSVFK
19.09
492.26
418.72
23.8
2000


 


20
FPMQSVFK
19.09
492.26
739.38
23.8
2000


 


21
FPMQSVFK
19.07
492.26
836.43
23.8
2000


 


22
GAAEILK
12.66
351.21
322.70
15.8
2000


 


23
GAAEILK
12.65
351.21
502.32
15.8
2000


 


24
GAAEILK
12.65
351.21
573.36
15.8
2000


 


25
GLLPAGTIVAHK
16.8
588.86
447.26
29.3
2000


 


26
GLLPAGTIVAHK
16.8
588.86
503.81
29.3
2000


 


27
GLLPAGTIVAHK
16.82
588.86
893.52
29.3
2000


 


28
GLLPAGTVVAHK
15.73
581.85
440.26
28.9
2000


 


29
GLLPAGTVVAHK
15.73
581.85
496.80
28.9
2000


 


30
GLLPAGTVVAHK
15.75
581.85
879.51
28.9
2000


 


31
GQIESIVIGK
16.8
522.31
616.40
25.5
5000


 


32
GQIESIVIGK
16.8
522.31
745.45
25.5
5000


 


33
GQIESIVIGK
16.8
522.31
858.53
25.5
5000


 


34
LDLNK
10.5
301.68
342.20
12.9
2000


 


35
LDLNK
10.5
301.68
374.24
12.9
2000


 


36
LDLNK
10.52
301.68
489.27
12.9
2000


 


37
LDLNQSVTVNR
15.11
629.84
338.19
31.6
2000


 


38
LDLNQSVTVNR
15.11
629.84
489.28
31.6
2000


 


39
LDLNQSVTVNR
15.11
629.84
675.38
31.6
2000


 


40
LDLNQTVIVNR
17.29
642.87
501.31
32.4
2000


 


41
LDLNQTVIVNR
17.29
642.87
600.38
32.4
2000


 


42
LDLNQTVIVNR
17.28
642.87
701.43
32.4
2000


 


43
LHLAMLVLHQVDQGK
19.84
567.99
568.83
24.7
2000


 


44
LHLAMLVLHQVDQGK
19.84
567.99
669.86
24.7
2000


 


45
LHLAMLVLHQVDQGK
19.84
567.99
726.41
24.7
2000


 


46
MHLAMLVLHQVDQGK
19.35
573.97
332.19
24.9
2000


 


47
MHLAMLVLHQVDQGK
19.35
573.97
669.86
24.9
2000


 


48
MHLAMLVLHQVDQGK
19.35
573.97
726.41
24.9
2000


 


49
NWTSMK
12.59
383.68
365.19
17.6
2000


 


50
NWTSMK
12.59
383.68
466.23
17.6
2000


 


51
NWTSMK
12.61
383.68
652.31
17.6
2000


 


52
QLSETSQALLWK
18.84
702.38
1162.61
35.8
2000


 


53
QLSETSQALLWK
18.84
702.38
446.28
35.8
2000


 


54
QLSETSQALLWK
18.84
702.38
845.49
35.8
2000


 


55
TGTSGIK
3.31
332.19
404.25
14.7
2000


 


56
TGTSGIK
3.29
332.19
505.30
14.7
2000


 


57
TGTSGIK
3.23
332.19
562.32
14.7
2000


 


58
TGTSGVR
1.56
339.18
418.24
15.1
2000


 


59
TGTSGVR
1.56
339.18
519.29
15.1
2000


 


60
TGTSGVR
1.56
339.18
576.31
15.1
2000


 


61
TNEAIIAQVAQAAYQFELK
26.27
703.37
1168.60
28.9
2000


 


62
TNEAIIAQVAQAAYQFELK
26.21
703.37
827.43
28.9
2000


 


63
TNEAIIAQVAQAAYQFELK
26.25
703.37
898.47
28.9
2000


 


64
TNEAIIAQVAQTAYQFELK
25.39
713.38
1198.61
29.2
2000


 


65
TNEAIIAQVAQTAYQFELK
25.37
713.38
827.43
29.2
2000


 


66
TNEAIIAQVAQTAYQFELK
25.37
713.38
898.47
29.2
2000


 


67
TQLSETSQALLWK
19.41
502.27
559.36
38.7
2000


 


68
TQLSETSQALLWK
19.41
502.27
630.40
22.7
2000


 


69
TQLSETSQALLWK
19.43
752.90
1162.61
22.7
2000


 


70
TVAVNR
7.08
330.20
388.23
14.6
2000


 


71
TVAVNR
7.08
330.20
459.27
14.6
2000


 


72
TVAVNR
7.05
330.20
558.34
14.6
2000


 


73
VLQNTWAPIMK
19.32
650.86
488.29
32.8
2000


 


74
VLQNTWAPIMK
19.3
650.86
559.33
32.8
2000


 


75
VLQNTWAPIMK
19.3
650.86
745.41
32.8
2000


 


76
WMVETTTGPER
15.5
653.81
761.38
33
2000


 


77
WMVETTTGPER
15.48
653.81
890.42
33
2000


 


78
WMVETTTGPER
15.48
653.81
989.49
33
2000


 


79
WMVETTTGPQR
15.19
653.32
457.25
33
2000


 


80
WMVETTTGPQR
15.19
653.32
889.44
33
2000


 


81
WMVETTTGPQR
15.23
653.32
988.51
33
2000









The other machine parameters used are as follows:













Scan type:
MRM


MRM planned:
yes


Polarity:
Positive


Ionising source:
Turbo V TM (Applied BioSystems)


Q1 setting:
Filtering with unit resolution


Q3 setting:
Filtering with unit resolution









Inter-scan pause:
5.00
msec


Scanning speed:
10
Da/s


Curtain gas:
50.00
psi


Cone voltage:
5500.00
V








Source temperature:
500.00° C.









Nebulising gas:
40.00
psi


Heating gas:
40.00
psi


Collision gas which induces dissociation:
9.00
psi








Dynamic filling:
activated









Declustering potential (DP):
100.00
V


Entry potential before Q0 (EP):
10.00
V


Collision cell exit potential (CXP):
15
V


Total cycle time:
1
sec


Detection window:
240
sec









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 13, the detection of the transition is considered to be positive and is labelled “1” in TABLE 14. When a transition has an area less than the positivity threshold described in TABLE 13, the transition is considered non-detected and is labelled “0” in TABLE 14.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.












TABLE 14





Transition







number
Sam74
Sam75
Sam76
Sam77
Sam78




















1
0
0
0
0
0


2
0
0
0
0
0


3
0
0
0
0
0


4
0
0
0
0
0


5
0
0
0
0
0


6
0
0
0
0
0


7
0
1
0
1
0


8
0
0
0
0
1


9
1
1
1
1
1


10
1
1
1
1
1


11
1
1
1
1
1


12
1
1
1
1
1


13
0
0
0
0
0


14
0
0
0
0
0


15
0
0
0
0
0


16
0
0
0
0
0


17
1
1
0
0
0


18
0
0
0
0
0


19
1
1
0
0
0


20
1
1
0
0
0


21
1
1
0
0
0


22
1
1
1
1
1


23
1
1
1
1
1


24
1
1
1
1
1


25
0
0
0
0
0


26
0
0
0
0
0


27
0
0
0
0
0


28
1
1
1
1
1


29
1
1
1
1
1


30
1
1
1
1
1


31
0
0
0
0
0


32
0
0
0
0
0


33
1
1
0
0
0


34
0
0
0
0
0


35
0
0
0
0
0


36
0
0
0
0
0


37
0
0
1
1
1


38
0
0
0
0
0


39
0
0
0
0
0


40
1
1
1
1
1


41
1
1
1
1
1


42
1
1
1
1
1


43
0
0
0
0
0


44
0
0
0
0
0


45
0
0
0
0
0


46
0
0
0
0
0


47
0
0
0
0
0


48
0
0
0
0
0


49
0
0
0
0
0


50
0
0
0
0
0


51
0
0
0
0
0


52
0
0
0
0
0


53
0
0
0
0
0


54
0
0
0
0
0


55
1
1
0
1
1


56
1
1
0
0
0


57
1
1
0
0
0


58
0
0
0
0
0


59
0
0
0
0
0


60
0
0
0
0
0


61
0
0
0
0
0


62
0
0
0
0
0


63
0
0
0
0
0


64
0
0
0
0
0


65
0
0
0
0
0


66
0
0
0
0
0


67
1
1
1
1
1


68
1
1
1
1
1


69
1
1
1
1
0


70
0
0
0
0
0


71
0
0
0
0
0


72
0
0
0
0
0


73
1
1
1
1
1


74
1
1
1
1
1


75
1
1
1
1
1


76
1
1
1
1
1


77
1
1
1
1
1


78
1
1
1
1
1


79
0
0
0
0
0


80
0
0
0
0
0


81
0
0
0
0
0









Samples Sam74 to Sam78 comprise at least one peptide which is characteristic of PERs. The bacteria present in samples Sam74 to Sam78 therefore express a beta-lactamase which confers on them a resistance to penicillins, cephalosporins and monobactams.
EXAMPLE 13
Identification of a Resistance to VEB Beta-Lactams
Samples Sam79 to Sam82 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 15.










TABLE 15







Names
Species









Sam79
A. baumannii



Sam80
A. baumannii



Sam81
A. baumannii



Sam82
E. coli










Samples Sam79 to Sam82 correspond to a species able to comprise a VEB resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 16 instead of the peptides from TABLE 3.













TABLE 16







Retention
(m/z)
(m/z)
Collision



Transition

time
filtered in
filtered
energy
Positivity


number
Peptide
(minutes)
Q1
in Q3
(eV)
threshold





















1
ANEEQMHK
1.44
493.72
458.20
23.9
2000


 


2
ANEEQMHK
1.44
493.72
672.31
23.9
2000


 


3
ANEEQMHK
1.44
493.72
801.36
23.9
2000


 


4
DWNTQYQNWATPTAMNK
19.05
1034.96
661.33
54.7
2000


 


5
DWNTQYQNWATPTAMNK
19
690.31
661.33
28.5
2000


 


6
DWNTQYQNWATPTAMNK
19.02
690.31
762.38
28.5
2000


 


7
ETSEINEK
6.84
475.23
390.20
22.8
2000


 


8
ETSEINEK
6.84
475.23
503.28
22.8
2000


 


9
ETSEINEK
6.83
475.23
719.36
22.8
2000


 


10
ETTTGSNR
1.38
433.20
433.22
20.4
1500


 


11
ETTTGSNR
1.38
433.20
534.26
20.4
1500


 


12
ETTTGSNR
1.38
433.20
635.31
20.4
1500


 


13
FLNANHFTDISIK
18.72
507.27
573.30
22.8
2000


 


14
FLNANHFTDISIK
18.72
507.27
630.32
22.8
2000


 


15
FLNANHFTDISIK
18.74
507.27
686.87
22.8
2000


 


16
FPIALAVLSEIDK
27.01
708.41
634.88
36.1
2000


 


17
FPIALAVLSEIDK
27.04
708.41
704.38
36.1
2000


 


18
FPIALAVLSEIDK
27.01
708.41
874.49
36.1
2000


 


19
GNLSFEQK
12.65
461.74
551.28
22.1
2000


 


20
GNLSFEQK
12.65
461.74
638.31
22.1
2000


 


21
GNLSFEQK
12.65
461.74
751.40
22.1
2000


 


22
GQLPK
7.19
271.67
243.16
11.2
2000


 


23
GQLPK
7.19
271.67
357.25
11.2
2000


 


24
GQLPK
7.19
271.67
485.31
11.2
2000


 


25
IEITPQDLLPK
21.67
633.87
405.74
31.9
2000


 


26
IEITPQDLLPK
21.67
633.87
810.47
31.9
2000


 


27
IEITPQDLLPK
21.63
633.87
911.52
31.9
2000


 


28
IENVLK
12.89
358.22
359.27
16.2
2000


 


29
IENVLK
12.91
358.22
473.31
16.2
2000


 


30
IENVLK
12.89
358.22
602.35
16.2
2000


 


31
IGVAIFNSNEK
18.09
596.32
738.34
29.7
2000


 


32
IGVAIFNSNEK
18.09
596.32
851.43
29.7
2000


 


33
IGVAIFNSNEK
18.09
596.32
922.46
29.7
2000


 


34
IISDIAK
12.6
380.23
331.23
17.4
2000


 


35
IISDIAK
12.58
380.23
533.29
17.4
2000


 


36
IISDIAK
12.56
380.23
646.38
17.4
2000


 


37
INNDFHFPMQSVMK
20.04
569.94
740.84
24.8
2000


 


38
INNDFHFPMQSVMK
20.04
569.94
797.86
24.8
2000


 


39
INNDFHFPMQSVMK
20.05
569.94
820.41
24.8
2000


 


40
LIGGTDSVQK
11.48
509.28
734.37
24.8
2000


 


41
LIGGTDSVQK
11.46
509.28
791.39
24.8
2000


 


42
LIGGTDSVQK
11.46
509.28
904.47
24.8
2000


 


43
LLIDTYNNK
15.7
547.30
639.31
26.9
2000


 


44
LLIDTYNNK
15.7
547.30
754.34
26.9
2000


 


45
LLIDTYNNK
15.7
547.30
867.42
26.9
2000


 


46
MWSPIK
16.91
381.20
357.25
17.5
2000


 


47
MWSPIK
16.91
381.20
444.28
17.5
2000


 


48
MWSPIK
16.87
381.20
630.36
17.5
2000


 


49
NQLLSK
10.59
351.71
347.23
15.8
2000


 


50
NQLLSK
10.59
351.71
460.31
15.8
2000


 


51
NQLLSK
10.59
351.71
588.37
15.8
2000


 


52
NTIVAHK
23.75
391.73
454.28
18.1
2000


 


53
NTIVAHK
23.73
391.73
567.36
18.1
2000


 


54
NTIVAHK
23.75
391.73
668.41
18.1
2000


 


55
SYDFIWK
19.92
479.74
446.28
23.1
2000


 


56
SYDFIWK
19.9
479.74
593.35
23.1
2000


 


57
SYDFIWK
19.9
479.74
708.37
23.1
2000


 


58
TWSPIK
14.95
366.21
357.25
16.6
2000


 


59
TWSPIK
14.93
366.21
444.28
16.6
2000


 


60
TWSPIK
14.95
366.21
630.36
16.6
2000









The other machine parameters used are as follows:













Scan type:
MRM


MRM planned:
yes


Polarity:
Positive


Ionising source:
Turbo V TM (Applied BioSystems)


Q1 setting:
Filtering with unit resolution


Q3 setting:
Filtering with unit resolution









Inter-scan pause:
5.00
msec


Scanning speed:
10
Da/s


Curtain gas:
50.00
psi


Cone voltage:
5500.00
V








Source temperature:
500.00° C.









Nebulising gas:
40.00
psi


Heating gas:
40.00
psi


Collision gas which induces dissociation:
9.00
psi








Dynamic filling:
activated









Declustering potential (DP):
100.00
V


Entry potential before Q0 (EP):
10.00
V


Collision cell exit potential (CXP):
15
V


Total cycle time:
1.2
sec


Detection window:
240
sec









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 16, the detection of the transition is considered to be positive and is labelled “1” in TABLE 17. When a transition has an area less than the positivity threshold described in TABLE 16, the transition is considered non-detected and is labelled “0” in TABLE 17.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.











TABLE 17





Transition






number
Sam79
Sam80
Sam81
Sam82



















1
0
0
0
0


2
0
0
0
0


3
0
0
0
0


4
0
0
0
0


5
0
0
0
0


6
0
0
0
0


7
0
0
0
0


8
0
0
0
0


9
0
0
0
0


10
1
1
1
1


11
1
1
1
1


12
1
1
1
0


13
0
1
1
0


14
0
1
1
0


15
0
1
1
0


16
0
0
0
0


17
0
0
0
0


18
0
0
0
0


19
0
0
0
0


20
0
0
0
0


21
0
0
0
0


22
0
0
0
0


23
0
0
0
0


24
0
0
0
0


25
1
1
1
1


26
1
1
1
1


27
1
1
1
1


28
0
0
0
0


29
0
0
0
0


30
0
0
0
0


31
0
0
0
0


32
0
0
0
0


33
0
0
0
0


34
0
0
0
0


35
0
0
0
0


36
0
0
0
0


37
0
0
0
0


38
0
0
0
0


39
0
0
0
0


40
1
1
1
0


41
0
1
0
0


42
1
0
1
0


43
0
0
0
0


44
0
0
0
0


45
0
0
0
0


46
0
0
0
0


47
0
0
0
0


48
0
0
0
0


49
0
0
0
0


50
0
0
0
0


51
0
0
0
0


52
0
0
0
0


53
0
0
0
0


54
0
0
0
0


55
1
1
1
0


56
1
1
1
0


57
1
1
1
0


58
0
0
0
0


59
0
0
0
0


60
0
0
0
0









Samples Sam79 to Sam82 comprise at least one peptide which is characteristic of VEBs. The bacteria present in samples Sam79 to Sam82 therefore express a beta-lactamase which confers on them a resistance to penicillins, cephalosporins and monobactams.
EXAMPLE 14
Identification of a Resistance to MOX Beta-Lactams
Sample Sam83 is identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 18.










TABLE 18







Names
Species









Sam83
E. coli










Sample Sam83 corresponds to a species able to comprise a MOX resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 19 instead of the peptides from TABLE 3.













TABLE 19







Retention
(m/z)
(m/z)
Collision



Transition

time
filtered
filtered in
energy
Positivity


number
Peptide
(minutes)
in Q1
Q3
(eV)
threshold





















1
AHYFNYGVADR
14.36
656.807
621.289
33.2
2000


 


2
AHYFNYGVADR
14.36
656.807
941.448
33.2
2000


 


3
AHYFNYGVADR
14.34
656.807
1104.511
33.2
2000


 


4
ANISGVDDK
9.88
459.73
533.257
21.9
2000


 


5
ANISGVDDK
9.86
459.73
620.289
21.9
2000


 


6
ANISGVDDK
9.86
459.73
733.373
21.9
2000


 


7
ANISGVHDK
7.75
470.746
555.289
22.6
2000


 


8
ANISGVHDK
7.67
470.746
642.321
22.6
2000


 


9
ANISGVHDK
7.69
470.746
755.405
22.6
2000


 


10
ASLFAPWLK
23.52
516.797
543.329
25.2
2000


 


11
ASLFAPWLK
23.56
516.797
614.366
25.2
2000


 


12
ASLFAPWLK
23.56
516.797
761.434
25.2
2000


 


13
EDKPFR
8.09
396.206
419.24
18.3
2000


 


14
EDKPFR
8.07
396.206
547.335
18.3
2000


 


15
EDKPFR
8.09
396.206
662.362
18.3
2000


 


16
ESGNLMLFNK
18.39
576.79
408.224
28.6
2000


 


17
ESGNLMLFNK
18.39
576.79
521.308
28.6
2000


 


18
ESGNLMLFNK
18.39
576.79
652.349
28.6
2000


 


19
ESGSQMLFNK
15.08
570.771
408.224
28.3
2000


 


20
ESGSQMLFNK
15.14
570.771
521.308
28.3
2000


 


21
ESGSQMLFNK
15.12
570.771
652.349
28.3
2000


 


22
GHPVLFNK
12.74
456.259
408.224
21.7
2000


 


23
GHPVLFNK
12.78
456.259
521.308
21.7
2000


 


24
GHPVLFNK
12.78
456.259
717.429
21.7
2000


 


25
GIGVVMLANR
18.19
515.297
604.324
25.1
2000


 


26
GIGVVMLANR
18.17
515.297
703.392
25.1
2000


 


27
GIGVVMLANR
18.17
515.297
859.482
25.1
2000


 


28
MQAYYR
11.12
416.195
501.246
19.5
2000


 


29
MQAYYR
11.14
416.195
572.283
19.5
2000


 


30
MQAYYR
11.12
416.195
700.341
19.5
2000


 


31
NSPIEAR
9.4
393.709
375.199
18.2
2000


 


32
NSPIEAR
9.4
393.709
488.283
18.2
2000


 


33
NSPIEAR
9.4
393.709
585.335
18.2
2000


 


34
NSPIEGTLK
13.36
479.764
379.226
23.1
2000


 


35
NSPIEGTLK
13.36
479.764
547.309
23.1
2000


 


36
NSPIEGTLK
13.34
479.764
757.445
23.1
2000


 


37
NYPNEGTLK
11.6
518.259
379.706
25.3
2000


 


38
NYPNEGTLK
11.62
518.259
661.352
25.3
2000


 


39
NYPNEGTLK
11.58
518.259
758.404
25.3
2000


 


40
QPFDR
9.48
331.666
437.214
14.6
2000


 


41
QPFDR
9.5
331.666
488.214
14.6
2000


 


42
QPFDR
9.48
331.666
534.267
14.6
2000


 


43
QWTPAYSPGSHR
13.34
693.831
486.238
35.3
2000


 


44
QWTPAYSPGSHR
13.34
693.831
640.316
35.3
2000


 


45
QWTPAYSPGSHR
13.34
693.831
971.469
35.3
2000


 


46
QWTPAYSR
13.46
504.749
496.251
24.5
2000


 


47
QWTPAYSR
13.48
504.749
593.304
24.5
2000


 


48
QWTPAYSR
13.46
504.749
694.352
24.5
2000


 


49
QYANPSIGLFGYLAASSMK
25.46
673.34
594.292
28
2000


 


50
QYANPSIGLFGYLAASSMK
25.5
673.34
594.31
28
2000


 


51
QYANPSIGLFGYLAASSMK
25.5
673.34
927.46
28
2000


 


52
QYSNPSIGLFGHLAASSMK
21.21
670.003
609.819
27.9
2000


 


53
QYSNPSIGLFGHLAASSMK
21.17
670.003
758.403
27.9
2000


 


54
QYSNPSIGLFGHLAASSMK
21.21
670.003
858.941
27.9
2000


 


55
TGSSNGFGAYVAFVPAR
20.79
850.923
343.209
100
2000


 


56
TGSSNGFGAYVAFVPAR
20.78
850.923
380.229
100
2000


 


57
TGSSNGFGAYVAFVPAR
20.78
850.923
442.277
100
2000


 


58
TGSTNGFGAYVAFVPAK
20.45
843.928
315.203
100
2000


 


59
TGSTNGFGAYVAFVPAK
20.46
843.928
366.226
100
2000


 


60
TGSTNGFGAYVAFVPAK
20.46
843.928
414.271
100
2000


 


61
TGSTSGFGAYVAFVPAK
20.64
553.951
632.377
24.3
2000


 


62
TGSTSGFGAYVAFVPAK
20.66
830.422
315.203
43.1
2000


 


63
TGSTSGFGAYVAFVPAK
20.66
830.422
414.271
43.1
2000


 


64
TLTATLGAYAVVQGSFELDDK
18.71
733.711
569.275
29.8
2000


 


65
TLTATLGAYAVVQGSFELDDK
18.71
733.711
654.328
29.8
2000


 


66
TLTATLGAYAVVQGSFELDDK
18.71
733.711
1137.542
29.8
2000


 


67
VSPGMLADEAYGIK
18.63
725.866
632.816
37.1
2000


 


68
VSPGMLADEAYGIK
18.63
725.866
866.425
37.1
2000


 


69
VSPGMLADEAYGIK
18.65
725.866
1167.571
37.1
2000


 


70
VTPAMLAEEPYGIK
19.05
506.934
577.334
22.8
2000


 


71
VTPAMLAEEPYGIK
19.05
759.897
659.839
39
2000


 


72
VTPAMLAEEPYGIK
19.07
759.897
906.457
39
2000


 


73
YAYPVSEQTLLAGNSAK
18.09
604.644
547.283
25.8
2000


 


74
YAYPVSEQTLLAGNSAK
18.07
604.644
660.368
25.8
2000


 


75
YAYPVSEQTLLAGNSAK
18.09
906.462
707.88
47.4
2000









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
yes



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00 
msec



Scanning speed:
10 
Da/s



Curtain gas:
40.00 
psi



Cone voltage:
5500.00 
V



Source temperature:
500.00°
C.



Nebulising gas:
40.00 
psi



Heating gas:
40.00 
psi



Collision gas which 
9.00 
psi



induces dissociation:












Dynamic filling:
activated











Declustering 
100.00 
V



potential (DP):





Entry potential 
10.00 
V



before Q0 (EP):





Collision cell exit 
15 
V



potential (CXP):





Total cycle time:
1 
sec



Detection window:
240 
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 19, the detection of the transition is considered to be positive and is labelled “1” in TABLE 20. When a transition has an area less than the positivity threshold described in TABLE 19, the transition is considered non-detected and is labelled “0” in TABLE 20.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.










TABLE 20







Transition




number
Sam83



















 1
0



 2
0



 3
0



 4
0



 5
0



 6
0



 7
1



 8
1



 9
1



10
0



11
0



12
0



13
0



14
0



15
0



16
0



17
0



18
0



19
0



20
0



21
0



22
0



23
0



24
0



25
0



26
0



27
0



28
0



29
0



30
0



31
0



32
0



33
0



34
0



35
0



36
0



37
0



38
0



39
0



40
0



41
0



42
0



43
1



44
1



45
1



46
0



47
0



48
0



49
0



50
0



51
0



52
0



53
0



54
0



55
0



56
0



57
0



58
0



59
0



60
0



61
0



62
0



63
0



64
0



65
0



66
0



67
1



68
1



69
1



70
0



71
0



72
0



73
0



74
0



75
0










Sample Sam83 comprises at least one peptide which is characteristic of MOXs. The bacteria present in sample Sam83 therefore express a beta-lactamase which confers on them a resistance to penicillins and to cephalosporins, with the exception of fourth-generation cephalosporins.
EXAMPLE 15
Identification of a Resistance to ACC Beta-Lactams
The samples corresponding to a species able to comprise an ACC resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 21 instead of the peptides from TABLE 3.












TABLE 21








(m/z)
(m/z)



Transition

Retention time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
ALTDTHIGYFK
15.83
422.56
457.24
25


 


2
ALTDTHIGYFK
15.83
422.56
514.27
25


 


3
ALTDTHIGYFK
15.83
422.56
627.35
25


 


4
AWKPADPAGTHR
10.49
436.23
470.25
26


 


5
AWKPADPAGTHR
10.49
436.23
638.34
26


 


6
AWKPADPAGTHR
10.49
436.23
669.34
26


 


7
DEPVHGNMEILGNEAYGIK
18.07
696
851.43
39


 


8
DEPVHGNMEILGNEAYGIK
18.07
696
1009.4
39


 


9
DEPVHGNMEILGNEAYGIK
18.07
696
1122.49
39


 


10
DTVDGLIQPLMQK
20.72
729.39
857.49
37


 


11
DTVDGLIQPLMQK
20.72
729.39
970.58
37


 


12
DTVDGLIQPLMQK
20.72
729.39
1027.6
37


 


13
DTVDSLIQPLMQK
21.62
744.39
857.49
38


 


14
DTVDSLIQPLMQK
21.62
744.39
1057.61
38


 


15
DTVDSLIQPLMQK
21.62
744.39
1172.63
38


 


16
IQHALTATHTGYFK
12.76
397.71
514.27
23


 


17
IQHALTATHTGYFK
12.76
397.71
615.31
23


 


18
IQHALTATHTGYFK
12.76
397.71
752.37
23


 


19
LDGNSTLQK
9.44
488.26
576.34
26


 


20
LDGNSTLQK
9.44
488.26
747.4
26


 


21
LDGNSTLQK
9.44
488.26
862.43
26


 


22
LSLDK
10.73
288.17
375.22
18


 


23
LSLDK
10.73
288.17
429.23
18


 


24
LSLDK
10.73
288.17
462.26
18


 


25
LSLEQSVSHYVPELR
20.3
586.31
776.43
33


 


26
LSLEQSVSHYVPELR
20.3
586.31
913.49
33


 


27
LSLEQSVSHYVPELR
20.3
586.31
1000.52
33


 


28
NEPIHVNMEVLGNEAYGIR
19.55
719.02
879.43
40


 


29
NEPIHVNMEVLGNEAYGIR
19.55
719.02
992.52
40


 


30
NEPIHVNMEVLGNEAYGIR
19.55
719.02
1163.55
40


 


31
NNIPGMSVAVTIR
18.3
457.92
559.36
27


 


32
NNIPGMSVAVTIR
18.3
686.37
933.52
35


 


33
NNIPGMSVAVTIR
18.3
686.37
1030.57
35


 


34
NTDQLMAYLK
18.78
598.8
625.34
31


 


35
NTDQLMAYLK
18.78
598.8
738.42
31


 


36
NTDQLMAYLK
18.78
598.8
981.51
31


 


37
NTTQLMTYLK
17.75
606.82
768.43
32


 


38
NTTQLMTYLK
17.75
606.82
896.49
32


 


39
NTTQLMTYLK
17.75
606.82
997.54
32


 


40
NYIYNYGLASK
15.9
653.33
752.39
34


 


41
NYIYNYGLASK
15.9
653.33
915.46
34


 


42
NYIYNYGLASK
15.9
653.33
1028.54
34


 


43
SISHYVPELR
15
400.88
514.3
24


 


44
SISHYVPELR
15
400.88
613.37
24


 


45
SISHYVPELR
15
400.88
776.43
24


 


46
TFAAILASYAQASGK
21.64
749.9
811.39
38


 


47
TFAAILASYAQASGK
21.64
749.9
882.43
38


 


48
TFAAILASYAQASGK
21.64
749.9
995.52
38


 


49
TLLPK
12.05
286.19
357.25
18


 


50
TLLPK
12.05
286.19
425.28
18


 


51
TLLPK
12.05
286.19
470.33
18


 


52
TNASDLIR
12.95
445.24
516.31
25


 


53
TNASDLIR
12.95
445.24
603.35
25


 


54
TNASDLIR
12.95
445.24
674.38
25


 


55
VTVAYK
10.34
340.7
381.21
20


 


56
VTVAYK
10.34
340.7
480.28
20


 


57
VTVAYK
10.34
340.7
581.33
20









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 16
Identification of a Resistance to ACT Beta-Lactams
The samples corresponding to a species able to comprise an ACT resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 22 instead of the peptides from TABLE 3.












TABLE 22







Retention
(m/z)
(m/z)



Transition

time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
AEEAHYAWGYR
14.21
676.81
815.38
34.8


 


2
AEEAHYAWGYR
14.21
676.81
952.44
34.8


 


3
AEEAHYAWGYR
14.21
676.81
1152.52
34.8


 


4
AIHVSPGMLDAEAYGVK
18.71
586.64
666.35
33.3


 


5
AIHVSPGMLDAEAYGVK
18.71
586.64
737.38
33.3


 


6
AIHVSPGMLDAEAYGVK
18.74
586.64
852.41
33.3


 


7
AVHVSPGMLDAEAYGVK
17.93
581.96
666.35
33.1


 


8
AVHVSPGMLDAEAYGVK
17.93
581.96
737.38
33.1


 


9
AVHVSPGMLDAEAYGVK
17.93
581.96
852.41
33.1


 


10
DMANWVMVNMKPDSLQDSSLK
22.23
803.71
896.45
44.2


 


11
DMANWVMVNMKPDSLQDSSLK
22.21
803.71
989.49
44.2


 


12
DMANWVMVNMKPDSLQDSSLK
22.23
803.71
1082.03
44.2


 


13
DNASLLR
12.76
394.72
401.29
22.4


 


14
DNASLLR
12.76
394.72
488.32
22.4


 


15
DNASLLR
12.76
394.72
559.36
22.4


 


16
EGITLAQSR
13.23
487.77
574.33
26.5


 


17
EGITLAQSR
13.25
487.77
675.38
26.5


 


18
EGITLAQSR
13.23
487.77
788.46
26.5


 


19
EVNPPAPPVNASWVHK
16.59
581.31
700.38
33.1


 


20
EVNPPAPPVNASWVHK
16.61
581.31
757.4
33.1


 


21
EVNPPAPPVNASWVHK
16.61
581.31
1134.61
33.1


 


22
FYQNWQPQWKPGTTR
17.43
968.98
531.29
47.6


 


23
FYQNWQPQWKPGTTR
17.43
968.98
1070.57
47.6


 


24
FYQNWQPQWKPGTTR
17.43
968.98
1198.63
47.6


 


25
GEISLDDPVTR
16.1
601.31
702.34
31.5


 


26
GEISLDDPVTR
16.1
601.31
815.43
31.5


 


27
GEISLDDPVTR
16.12
601.31
902.46
31.5


 


28
GEISLGDPVTK
15.7
558.3
559.31
29.6


 


29
GEISLGDPVTK
15.68
558.3
616.33
29.6


 


30
GEISLGDPVTK
15.68
558.3
816.45
29.6


 


31
GLTLAQSR
12.67
423.25
461.25
23.6


 


32
GLTLAQSR
12.68
423.25
574.33
23.6


 


33
GLTLAQSR
12.65
423.25
675.38
23.6


 


34
LDHTWINVPK
16.79
611.83
497.78
31.9


 


35
LDHTWINVPK
16.79
611.83
756.44
31.9


 


36
LDHTWINVPK
16.79
611.83
857.49
31.9


 


37
MLDLATYTAGGLPLQVPDEVK
23.87
744.39
512.79
41.2


 


38
MLDLATYTAGGLPLQVPDEVK
23.89
744.39
587.3
41.2


 


39
MLDLATYTAGGLPLQVPDEVK
23.89
1116.09
587.3
54.1


 


40
QGIALAQSR
12.72
472.27
574.33
25.8


 


41
QGIALAQSR
12.7
472.27
645.37
25.8


 


42
QGIALAQSR
12.72
472.27
758.45
25.8


 


43
QGISLAQSR
12.83
480.27
661.36
26.1


 


44
QGISLAQSR
12.83
480.27
774.45
26.1


 


45
QGISLAQSR
12.83
480.27
831.47
26.1


 


46
QIGIVMLANK
18.95
543.82
576.32
28.9


 


47
QIGIVMLANK
18.95
543.82
675.39
28.9


 


48
QIGIVMLANK
18.95
543.82
845.49
28.9


 


49
QIGIVMLANTSYPNPAR
21.86
615.66
554.31
34.8


 


50
QIGIVMLANTSYPNPAR
21.86
615.66
717.37
34.8


 


51
QIGIVMLANTSYPNPAR
21.86
922.99
554.31
45.6


 


52
QLAEVVANTVTPLMK
21.94
807.45
488.29
40.5


 


53
QLAEVVANTVTPLMK
21.94
807.45
974.53
40.5


 


54
QLAEVVANTVTPLMK
21.94
807.45
1073.6
40.5


 


55
QLAEVVER
13.05
472.26
502.3
25.8


 


56
QLAEVVER
13.03
472.26
631.34
25.8


 


57
QLAEVVER
13.03
472.26
702.38
25.8


 


58
QLGIVMLANK
19.27
543.82
576.32
28.9


 


59
QLGIVMLANK
19.27
543.82
675.39
28.9


 


60
QLGIVMLANK
19.27
543.82
845.49
28.9


 


61
SYPNPAR
9.83
402.7
343.21
22.7


 


62
SYPNPAR
9.83
402.7
457.25
22.7


 


63
SYPNPAR
9.83
402.7
554.31
22.7


 


64
TFTGVLGGDAIAR
18.42
639.35
659.35
33.1


 


65
TFTGVLGGDAIAR
18.39
639.35
772.43
33.1


 


66
TFTGVLGGDAIAR
18.42
639.35
1029.57
33.1


 


67
TGSTGGFGSYVAFIPEK
21.14
573.29
373.21
32.7


 


68
TGSTGGFGSYVAFIPEK
21.14
573.29
633.36
32.7


 


69
TGSTGGFGSYVAFIPEK
21.14
573.29
704.4
32.7


 


70
TVTPLMK
13.65
395.23
488.29
22.4


 


71
TVTPLMK
13.65
395.23
589.34
22.4


 


72
TVTPLMK
13.62
395.23
688.41
22.4


 


73
TVVEGSDNK
4.64
474.74
520.24
25.9


 


74
TVVEGSDNK
4.64
474.74
649.28
25.9


 


75
TVVEGSDNK
4.64
474.74
748.35
25.9


 


76
VALAPLPAR
15.96
454.29
553.35
25


 


77
VALAPLPAR
15.99
454.29
624.38
25


 


78
VALAPLPAR
15.96
454.29
737.47
25


 


79
VALAPLPVAEVNPPAPPVK
21.12
627.04
705.43
35.4


 


80
VALAPLPVAEVNPPAPPVK
21.14
627.04
762.94
35.4


 


81
VALAPLPVAEVNPPAPPVK
21.14
627.04
819.47
35.4


 


82
VEAAYR
8.39
354.69
409.22
20.6


 


83
VEAAYR
8.39
354.69
480.26
20.6


 


84
VEAAYR
8.39
354.69
609.3
20.6


 


85
VFKPLK
11.66
366.24
357.25
21.1


 


86
VFKPLK
11.66
366.24
485.35
21.1


 


87
VFKPLK
11.66
366.24
632.41
21.1


 


88
VGAMYQGLGWEMLNWPVDAK
26.23
755.7
529.3
41.8


 


89
VGAMYQGLGWEMLNWPVDAK
26.23
755.7
829.42
41.8


 


90
VGAMYQGLGWEMLNWPVDAK
26.26
755.7
1073.55
41.8


 


91
VLKPLK
10.38
349.25
357.25
20.4


 


92
VLKPLK
10.36
349.25
485.35
20.4


 


93
VLKPLK
10.36
349.25
598.43
20.4


 


94
VSPGMLDAQAYGMK
17.62
734.35
641.3
37.3


 


95
VSPGMLDAQAYGMK
17.62
734.35
883.4
37.3


 


96
VSPGMLDAQAYGMK
17.62
734.35
996.48
37.3


 


97
VSPGMLDAQAYGVK
17.36
718.37
625.32
36.6


 


98
VSPGMLDAQAYGVK
17.36
718.37
851.43
36.6


 


99
VSPGMLDAQAYGVK
17.36
718.37
964.51
36.6


 


100
YWPQLTGK
17.33
496.76
322.19
26.9


 


101
YWPQLTGK
17.33
496.76
643.38
26.9


 


102
YWPQLTGK
17.31
496.76
829.46
26.9









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 17
Identification of a Resistance to CMY Beta-Lactams
The samples corresponding to a species able to comprise a CMY resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 23 instead of the peptides from TABLE 3.












TABLE 23







Retention
(m/z)
(m/z)
Collision


Transition

time
filtered in
filtered in
energy


number
Peptide
(minutes)
Q1
Q3
(eV)




















1
AALLR
10.85
272.18
288.2
17


 


2
AALLR
10.85
272.18
401.29
17


 


3
AALLR
10.85
272.18
472.32
17


 


4
ADSIINGSDNK
10.62
567.28
747.36
30


 


5
ADSIINGSDNK
10.62
567.28
860.45
30


 


6
ADSIINGSDNK
10.62
567.28
947.48
30


 


7
AELLR
11.13
301.19
401.29
18


 


8
AELLR
11.13
301.19
427.26
18


 


9
AELLR
11.13
301.19
530.33
18


 


10
ALQQAISLTHK
13.79
605.35
698.42
32


 


11
ALQQAISLTHK
13.79
605.35
769.46
32


 


12
ALQQAISLTHK
13.79
605.35
897.52
32


 


13
AVHVSPGQLDAEAYGVK
15.59
580.97
737.38
33


 


14
AVHVSPGQLDAEAYGVK
15.59
580.97
776.4
33


 


15
AVHVSPGQLDAEAYGVK
15.59
580.97
852.41
33


 


16
DYAC[CAM]GYR
9.86
452.68
555.23
25


 


17
DYAC[CAM]GYR
9.86
452.68
626.27
25


 


18
DYAC[CAM]GYR
9.86
452.68
789.33
25


 


19
DYALGYR
13.44
429.21
508.29
24


 


20
DYALGYR
13.44
429.21
579.32
24


 


21
DYALGYR
13.44
429.21
742.39
24


 


22
EGKPVHASPGQLDAEAYGVK
13.47
685.02
737.38
38


 


23
EGKPVHASPGQLDAEAYGVK
13.47
685.02
852.41
38


 


24
EGKPVHASPGQLDAEAYGVK
13.47
685.02
965.49
38


 


25
EGKPVHGSPGQLDAEAYGVK
13.08
510.51
537.3
29


 


26
EGKPVHGSPGQLDAEAYGVK
13.08
510.51
666.35
29


 


27
EGKPVHGSPGQLDAEAYGVK
13.08
510.51
737.38
29


 


28
EGKPVHVSPEQLDAEAYGVK
15.07
539.03
737.38
30


 


29
EGKPVHVSPEQLDAEAYGVK
15.07
539.03
852.41
30


 


30
EGKPVHVSPEQLDAEAYGVK
15.07
718.37
852.41
40


 


31
EGKPVHVSPGQFDAEAYGVK
15.01
529.52
537.3
29


 


32
EGKPVHVSPGQFDAEAYGVK
15.01
529.52
632.33
29


 


33
EGKPVHVSPGQFDAEAYGVK
15.01
705.69
999.48
39


 


34
EGKPVHVSPGQLDAEAYC[CAM]VK
14.63
546.77
569.28
30


 


35
EGKPVHVSPGQLDAEAYC[CAM]VK
14.63
546.77
640.31
30


 


36
EGKPVHVSPGQLDAEAYC[CAM]VK
14.63
546.77
769.35
30


 


37
EGKPVHVSPGQLDAEAYGVK
14.65
521.02
537.3
29


 


38
EGKPVHVSPGQLDAEAYGVK
14.65
521.02
737.38
29


 


39
EGKPVHVSPGQLDAEAYGVK
14.65
521.02
852.41
29


 


40
EGKPVHVSPGQLDAGAYGVK
14.19
503.02
594.32
28


 


41
EGKPVHVSPGQLDAGAYGVK
14.19
503.02
665.36
28


 


42
EGKPVHVSPGQLDAGAYGVK
14.19
503.02
780.39
28


 


43
EGKPVHVSPGQLNAEAYGVK
14.25
520.78
537.3
29


 


44
EGKPVHVSPGQLNAEAYGVK
14.25
520.78
737.38
29


 


45
EGKPVHVSPGQLNAEAYGVK
14.25
520.78
834.45
29


 


46
EGKPVHVTPGQLDAEAYGVK
14.72
524.53
848.46
29


 


47
EGKPVHVTPGQLDAEAYGVK
14.72
699.03
852.41
39


 


48
EGKPVHVTPGQLDAEAYGVK
14.72
699.03
1247.63
39


 


49
EGKPVYVSPGQLDAEAYGVK
16.73
703.03
852.41
39


 


50
EGKPVYVSPGQLDAEAYGVK
16.73
703.03
860.45
39


 


51
EGKPVYVSPGQLDAEAYGVK
16.73
703.03
1247.63
39


 


52
ESGASVSEQTLFDIGSVSK
20.37
970.98
976.42
48


 


53
ESGASVSEQTLFDIGSVSK
20.37
970.98
1066.58
48


 


54
ESGASVSEQTLFDIGSVSK
20.37
970.98
1194.64
48


 


55
FSDPVTK
11.61
397.21
559.31
22


 


56
FSDPVTK
11.61
397.21
646.34
22


 


57
FSDPVTK
11.61
397.21
647.3
22


 


58
FYQNWQPQWAPGAK
18.61
860.92
867.38
43


 


59
FYQNWQPQWAPGAK
18.61
860.92
982.51
43


 


60
FYQNWQPQWAPGAK
18.61
860.92
1168.59
43


 


61
FYQNWQPQWTPGAK
18.53
875.92
884.46
44


 


62
FYQNWQPQWTPGAK
18.53
875.92
1012.52
44


 


63
FYQNWQPQWTPGAK
18.53
875.92
1198.6
44


 


64
HAPWLK
11.85
376.22
543.33
22


 


65
HAPWLK
11.85
376.22
605.32
22


 


66
HAPWLK
11.85
376.22
614.37
22


 


67
IPDDVR
9.9
357.69
504.24
21


 


68
IPDDVR
9.9
357.69
540.27
21


 


69
IPDDVR
9.9
357.69
601.29
21


 


70
LAHTWIK
12.56
434.76
547.32
24


 


71
LAHTWIK
12.56
434.76
684.38
24


 


72
LAHTWIK
12.56
434.76
755.42
24


 


73
LAHTWITVPENEQK
15.87
555.96
609.31
32


 


74
LAHTWITVPENEQK
15.87
555.96
744.35
32


 


75
LAHTWITVPENEQK
15.87
555.96
823.45
32


 


76
LAHTWITVPQSEQK
15.75
546.63
1029.56
31


 


77
LAHTWITVPQSEQK
15.75
819.44
1029.56
41


 


78
LAHTWITVPQSEQK
15.75
819.44
1215.64
41


 


79
LDAEAYGVK
12.86
483.25
537.3
26


 


80
LDAEAYGVK
12.86
483.25
737.38
26


 


81
LDAEAYGVK
12.86
483.25
852.41
26


 


82
LLHLATYTAGGLPLK
19.26
523.31
584.38
30


 


83
LLHLATYTAGGLPLK
19.26
523.31
655.41
30


 


84
LLHLATYTAGGLPLK
19.26
523.31
756.46
30


 


85
LLHLATYTAGGLPLQFPDDVR
22.76
575.06
601.29
32


 


86
LLHLATYTAGGLPLQFPDDVR
22.76
766.41
1086.56
42


 


87
LLHLATYTAGGLPLQFPDDVR
22.76
766.41
1098.59
42


 


88
NYAWGYR
14.18
465.22
581.28
25


 


89
NYAWGYR
14.18
465.22
652.32
25


 


90
NYAWGYR
14.18
465.22
815.38
25


 


91
NYPIPAR
12.32
415.73
456.29
23


 


92
NYPIPAR
12.32
415.73
553.35
23


 


93
NYPIPAR
12.32
415.73
716.41
23


 


94
NYPNEAR
6.92
432.2
489.21
24


 


95
NYPNEAR
6.92
432.2
586.29
24


 


96
NYPNEAR
6.92
432.2
749.36
24


 


97
SLC[CAM]C[CAM]ALLLTAPLSTFAAAK
26.05
670.02
905.51
38


 


98
SLC[CAM]C[CAM]ALLLTAPLSTFAAAK
26.05
1004.53
1077.59
49


 


99
SLC[CAM]C[CAM]ALLLTAPLSTFAAAK
26.05
1004.53
1190.68
49


 


100
SNVTDMAR
10.56
447.21
492.22
25


 


101
SNVTDMAR
10.56
447.21
593.27
25


 


102
SNVTDMAR
10.56
447.21
692.34
25


 


103
TALLHFYQNWQPQWAPGAK
21.7
752.72
854.45
42


 


104
TALLHFYQNWQPQWAPGAK
21.7
752.72
974.51
42


 


105
TALLHFYQNWQPQWAPGAK
21.7
752.72
1088.55
42


 


106
TDSIINGSDSK
10.86
568.78
720.35
30


 


107
TDSIINGSDSK
10.86
568.78
833.44
30


 


108
TDSIINGSDSK
10.86
568.78
920.47
30


 


109
TFIGVLGGDAIAR
20.29
645.36
659.35
33


 


110
TFIGVLGGDAIAR
20.29
645.36
772.43
33


 


111
TFIGVLGGDAIAR
20.29
645.36
928.52
33


 


112
TFNGVLGGDC[CAM]IAR
16.85
690.34
748.34
35


 


113
TFNGVLGGDC[CAM]IAR
16.85
690.34
861.42
35


 


114
TFNGVLGGDC[CAM]IAR
16.85
690.34
1131.56
35


 


115
TFNGVLGGEAIAR
17.2
435.57
673.36
26


 


116
TFNGVLGGEAIAR
17.2
652.85
673.36
34


 


117
TFNGVLGGEAIAR
17.2
652.85
786.45
34


 


118
TGSTVGFGSYVAFVPEK
20.65
873.44
1039.55
43


 


119
TGSTVGFGSYVAFVPEK
20.65
873.44
1096.57
43


 


120
TGSTVGFGSYVAFVPEK
20.65
873.44
1243.64
43


 


121
TGYTGGFGSYVAFVPEK
20.58
890.43
1039.55
44


 


122
TGYTGGFGSYVAFVPEK
20.58
890.43
1096.57
44


 


123
TGYTGGFGSYVAFVPEK
20.58
890.43
1243.64
44


 


124
TLQQGIELAQSR
15.04
448.58
461.25
26


 


125
TLQQGIELAQSR
15.04
672.37
703.37
35


 


126
TLQQGIELAQSR
15.04
672.37
873.48
35


 


127
TSSADLLAFVK
20.76
576.32
805.48
30


 


128
TSSADLLAFVK
20.76
576.32
876.52
30


 


129
TSSADLLAFVK
20.76
576.32
963.55
30


 


130
TSSADLLR
12.72
431.73
587.35
24


 


131
TSSADLLR
12.72
431.73
674.38
24


 


132
TSSADLLR
12.72
431.73
761.42
24


 


133
TYYFTWGK
18.46
533.26
801.39
28


 


134
TYYFTWGK
18.46
533.26
919.4
28


 


135
TYYFTWGK
18.46
533.26
964.46
28


 


136
VAALPAVEVNPPAPAVK
18.04
821.98
964.55
41


 


137
VAALPAVEVNPPAPAVK
18.04
821.98
1021.57
41


 


138
VAALPAVEVNPPAPAVK
18.04
821.98
1120.64
41


 


139
VAFAALPAVEVNPPAPAVK
21.03
621.02
679.41
35


 


140
VAFAALPAVEVNPPAPAVK
21.03
621.02
793.46
35


 


141
VAFAALPAVEVNPPAPAVK
21.03
931.03
1021.57
46


 


142
VALAAIPAVEVNPPAPAVK
20.17
457.52
679.41
26


 


143
VALAAIPAVEVNPPAPAVK
20.17
609.7
679.41
34


 


144
VALAAIPAVEVNPPAPAVK
20.17
609.7
793.46
34


 


145
VALAALHTVEVNPPAPAVK
18
475.03
582.36
27


 


146
VALAALHTVEVNPPAPAVK
18
475.03
679.41
27


 


147
VALAALHTVEVNPPAPAVK
18
633.03
679.41
36


 


148
VALAALPAVEINPPAPAVK
21.5
614.37
679.41
35


 


149
VALAALPAVEINPPAPAVK
21.5
614.37
793.46
35


 


150
VALAALPAVEINPPAPAVK
21.5
614.37
935.56
35


 


151
VALAALPTVEVNPPAPAVK
20.41
619.7
679.41
35


 


152
VALAALPTVEVNPPAPAVK
20.41
619.7
793.46
35


 


153
VALAALPTVEVNPPAPAVK
20.41
619.7
1021.57
35


 


154
VAPAVEVNPPAPAVK
15.16
729.92
793.46
37


 


155
VAPAVEVNPPAPAVK
15.16
729.92
892.53
37


 


156
VAPAVEVNPPAPAVK
15.16
729.92
1021.57
37


 


157
VEAYWR
13.37
412.21
524.26
23


 


158
VEAYWR
13.37
412.21
595.3
23


 


159
VEAYWR
13.37
412.21
724.34
23


 


160
VILEANPTAAPR
14.25
417.91
612.35
25


 


161
VILEANPTAAPR
14.25
626.36
797.43
33


 


162
VILEANPTAAPR
14.25
626.36
1039.55
33


 


163
VSLEANPTAAPR
13.15
613.33
726.39
32


 


164
VSLEANPTAAPR
13.15
613.33
797.43
32


 


165
VSLEANPTAAPR
13.15
613.33
926.47
32


 


166
WIQVNMDASR
16.68
610.3
693.3
32


 


167
WIQVNMDASR
16.68
610.3
792.37
32


 


168
WIQVNMDASR
16.68
610.3
920.43
32


 


169
WVQANMDASR
12.82
589.27
764.34
31


 


170
WVQANMDASR
12.82
589.27
892.39
31


 


171
WVQANMDASR
12.82
589.27
991.46
31


 


172
WVQVNMDASR
15.27
603.29
792.37
32


 


173
WVQVNMDASR
15.27
603.29
920.43
32


 


174
WVQVNMDASR
15.27
603.29
1019.49
32


 


175
YWSELTGK
14.9
492.25
547.31
27


 


176
YWSELTGK
14.9
492.25
634.34
27


 


177
YWSELTGK
14.9
492.25
820.42
27









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 18
Identification of a Resistance to CTX-M Beta-Lactams
The samples corresponding to a species able to comprise a CTX-M resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 24 instead of the peptides from TABLE 3.












TABLE 24







Retention
(m/z)
(m/z)



Transition

time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
AGADVASLR
11.83
430.24
446.27
24


 


2
AGADVASLR
11.83
430.24
485.24
24


 


3
AGADVASLR
11.83
430.24
660.37
24


 


4
AGLPASWVVGDK
18.32
600.32
790.41
31


 


5
AGLPASWVVGDK
18.32
600.32
861.45
31


 


6
AGLPASWVVGDK
18.32
600.32
958.5
31


 


7
AGLPTSWTAGDK
15.73
602.3
764.36
32


 


8
AGLPTSWTAGDK
15.73
602.3
865.41
32


 


9
AGLPTSWTAGDK
15.73
602.3
962.46
32


 


10
AGLPTSWTVGDR
17.31
630.32
820.39
33


 


11
AGLPTSWTVGDR
17.31
630.32
921.44
33


 


12
AGLPTSWTVGDR
17.31
630.32
1018.5
33


 


13
AGLPTSWVVGDK
18.62
615.33
790.41
32


 


14
AGLPTSWVVGDK
18.62
615.33
891.46
32


 


15
AGLPTSWVVGDK
18.62
615.33
988.51
32


 


16
AIGDDTFR
12.79
447.72
653.29
25


 


17
AIGDDTFR
12.79
447.72
710.31
25


 


18
AIGDDTFR
12.79
447.72
823.39
25


 


19
AMAVAAVLK
16.36
437.26
501.34
24


 


20
AMAVAAVLK
16.36
437.26
600.41
24


 


21
AMAVAAVLK
16.36
437.26
671.45
24


 


22
APLILVTYFTQPEQK
23.95
583.33
730.37
33


 


23
APLILVTYFTQPEQK
23.95
874.49
1040.5
43


 


24
APLILVTYFTQPEQK
23.95
874.49
1141.55
43


 


25
APLVLVTYFTQPEPK
23.37
568.32
699.37
32


 


26
APLVLVTYFTQPEPK
23.37
568.32
846.44
32


 


27
APLVLVTYFTQPEPK
23.37
851.97
1110.55
42


 


28
APLVLVTYFTQPQQNAENR
22.93
730.38
956.45
41


 


29
APLVLVTYFTQPQQNAENR
22.93
1095.07
1185.56
53


 


30
APLVLVTYFTQPQQNAENR
22.93
1095.07
1233.69
53


 


31
APLVLVTYFTQPQQNAER
23.02
692.37
745.36
39


 


32
APLVLVTYFTQPQQNAER
23.02
692.37
842.41
39


 


33
APLVLVTYFTQPQQNAER
23.02
692.37
857.51
39


 


34
APLVLVTYFTQSEPK
23.53
564.98
689.35
32


 


35
APLVLVTYFTQSEPK
23.53
846.96
1100.53
42


 


36
APLVLVTYFTQSEPK
23.53
846.96
1199.59
42


 


37
AQLVAWLK
19.52
464.78
517.31
25


 


38
AQLVAWLK
19.52
464.78
616.38
25


 


39
AQLVAWLK
19.52
464.78
729.47
25


 


40
AQLVMWLK
20.53
494.79
577.32
27


 


41
AQLVMWLK
20.53
494.79
676.39
27


 


42
AQLVMWLK
20.53
494.79
789.47
27


 


43
ASDLVNYNPIAEK
16.72
717.37
834.44
37


 


44
ASDLVNYNPIAEK
16.72
717.37
948.48
37


 


45
ASDLVNYNPIAEK
16.72
717.37
1047.55
37


 


46
DFLAAAAK
14.5
403.72
431.26
23


 


47
DFLAAAAK
14.5
403.72
518.26
23


 


48
DFLAAAAK
14.5
403.72
544.35
23


 


49
DILASAAK
12.62
394.73
447.26
22


 


50
DILASAAK
12.62
394.73
560.34
22


 


51
DILASAAK
12.62
394.73
571.31
22


 


52
DNTQVLYR
12.19
504.76
550.33
27


 


53
DNTQVLYR
12.19
504.76
678.39
27


 


54
DNTQVLYR
12.19
504.76
779.44
27


 


55
DTTTPLAMAQALR
19.92
694.86
760.41
36


 


56
DTTTPLAMAQALR
19.92
694.86
873.5
36


 


57
DTTTPLAMAQALR
19.92
694.86
970.55
36


 


58
DTTTPLAMAQSLR
19.22
702.86
776.41
36


 


59
DTTTPLAMAQSLR
19.22
702.86
889.49
36


 


60
DTTTPLAMAQSLR
19.22
702.86
986.55
36


 


61
DTTTPLAMAQTLR
18.99
709.87
719.39
36


 


62
DTTTPLAMAQTLR
18.99
709.87
790.42
36


 


63
DTTTPLAMAQTLR
18.99
709.87
1000.56
36


 


64
DVLAAAAR
12.11
393.73
459.27
22


 


65
DVLAAAAR
12.11
393.73
572.35
22


 


66
DVLAAAAR
12.11
393.73
671.42
22


 


67
EIGDETFR
12.99
483.73
552.28
26


 


68
EIGDETFR
12.99
483.73
667.3
26


 


69
EIGDETFR
12.99
483.73
724.33
26


 


70
EQLVTWLK
19.13
508.79
547.32
27


 


71
EQLVTWLK
19.13
508.79
646.39
27


 


72
EQLVTWLK
19.13
508.79
759.48
27


 


73
GNTTGSASIQAGLPK
13.81
701.37
813.48
36


 


74
GNTTGSASIQAGLPK
13.81
701.37
1028.57
36


 


75
GNTTGSASIQAGLPK
13.81
701.37
1129.62
36


 


76
HDVLASAAK
9.32
456.25
659.41
25


 


77
HDVLASAAK
9.32
456.25
765.39
25


 


78
HDVLASAAK
9.32
456.25
774.44
25


 


79
HDVLASAAR
9.88
470.25
588.35
26


 


80
HDVLASAAR
9.88
470.25
687.41
26


 


81
HDVLASAAR
9.88
470.25
802.44
26


 


82
HLTLGSALGETQR
15.07
691.87
918.46
35


 


83
HLTLGSALGETQR
15.07
691.87
1031.55
35


 


84
HLTLGSALGETQR
15.07
691.87
1132.6
35


 


85
LAELEQQSGGR
11.17
594.3
761.35
31


 


86
LAELEQQSGGR
11.17
594.3
874.44
31


 


87
LAELEQQSGGR
11.17
594.3
1003.48
31


 


88
LAGLER
11.22
329.7
474.27
20


 


89
LAGLER
11.22
329.7
484.28
20


 


90
LAGLER
11.22
329.7
545.3
20


 


91
LDGTEPTLNTAIPGDPR
16.6
589.64
1053.57
33


 


92
LDGTEPTLNTAIPGDPR
16.6
883.95
1053.57
44


 


93
LDGTEPTLNTAIPGDPR
16.6
883.95
1154.62
44


 


94
LGVALIDTADNAQTLYR
20.27
917.49
980.48
45


 


95
LGVALIDTADNAQTLYR
20.27
917.49
1051.52
45


 


96
LGVALIDTADNAQTLYR
20.27
917.49
1152.56
45


 


97
LGVALIDTADNTHVLYR
19.46
624.34
801.42
35


 


98
LGVALIDTADNTHVLYR
19.46
624.34
902.48
35


 


99
LGVALIDTADNTHVLYR
19.46
624.34
1189.6
35


 


100
LGVALIDTK
16.93
465.29
589.36
25


 


101
LGVALIDTK
16.93
465.29
660.39
25


 


102
LGVALIDTK
16.93
465.29
816.48
25


 


103
LGVALINTADNSR
16.92
672.37
777.35
35


 


104
LGVALINTADNSR
16.92
672.37
890.43
35


 


105
LGVALINTADNSR
16.92
672.37
1003.52
35


 


106
LGVALINTADNTQTLYR
19.63
621.67
1081.53
35


 


107
LGVALINTADNTQTLYR
19.63
932
1081.53
46


 


108
LGVALINTADNTQTLYR
19.63
932
1182.57
46


 


109
LGVPLIDTADNTQVLYR
21.54
944.51
1008.51
47


 


110
LGVPLIDTADNTQVLYR
21.54
944.51
1079.55
47


 


111
LGVPLIDTADNTQVLYR
21.54
944.51
1180.6
47


 


112
LIAHLGGPGK
12.27
321.53
358.21
20


 


113
LIAHLGGPGK
12.27
321.53
415.23
20


 


114
LIAHLGGPGK
12.27
321.53
528.31
20


 


115
LIAQLGGQGGVTAFAR
18.73
779.94
963.5
39


 


116
LIAQLGGQGGVTAFAR
18.73
779.94
1020.52
39


 


117
LIAQLGGQGGVTAFAR
18.73
779.94
1133.61
39


 


118
LISHVGGPASVTAFAR
16.27
528.29
565.31
30


 


119
LISHVGGPASVTAFAR
16.27
528.29
664.38
30


 


120
LISHVGGPASVTAFAR
16.27
791.94
1033.54
40


 


121
LLLNQR
12.81
378.74
417.22
22


 


122
LLLNQR
12.81
378.74
530.3
22


 


123
LLLNQR
12.81
378.74
643.39
22


 


124
NLTLGNALGDTQR
16.67
686.86
931.46
35


 


125
NLTLGNALGDTQR
16.67
686.86
1044.54
35


 


126
NLTLGNALGDTQR
16.67
686.86
1145.59
35


 


127
NLTLGSALGETQR
17.15
453.91
590.29
27


 


128
NLTLGSALGETQR
17.15
680.36
918.46
35


 


129
NLTLGSALGETQR
17.15
680.36
1031.55
35


 


130
QLGDDTFR
13.1
476.23
653.29
26


 


131
QLGDDTFR
13.1
476.23
710.31
26


 


132
QLGDDTFR
13.1
476.23
823.39
26


 


133
SDLVNYSPIAEK
16.24
668.34
807.42
34


 


134
SDLVNYSPIAEK
16.24
668.34
921.47
34


 


135
SDLVNYSPIAEK
16.24
668.34
1020.54
34


 


136
SESEPSLLNQR
13.8
630.31
730.42
33


 


137
SESEPSLLNQR
13.8
630.31
827.47
33


 


138
SESEPSLLNQR
13.8
630.31
1043.55
33


 


139
SLGDESFR
12.8
455.72
653.29
25


 


140
SLGDESFR
12.8
455.72
710.31
25


 


141
SLGDESFR
12.8
455.72
823.39
25


 


142
SSDLINYNPIAEK
17.68
732.37
834.44
37


 


143
SSDLINYNPIAEK
17.68
732.37
948.48
37


 


144
SSDLINYNPIAEK
17.68
732.37
1061.56
37


 


145
SSDLINYNPITEK
17.72
747.38
864.45
38


 


146
SSDLINYNPITEK
17.72
747.38
978.49
38


 


147
SSDLINYNPITEK
17.72
747.38
1091.57
38


 


148
SWGVGDK
11.6
374.68
475.25
21


 


149
SWGVGDK
11.6
374.68
602.26
21


 


150
SWGVGDK
11.6
374.68
661.33
21


 


151
TELTLNTAIPGDPR
17.63
749.4
826.44
38


 


152
TELTLNTAIPGDPR
17.63
749.4
940.48
38


 


153
TELTLNTAIPGDPR
17.63
749.4
957.53
38


 


154
TEPTLNSAIPGDPR
15.33
734.38
812.43
37


 


155
TEPTLNSAIPGDPR
15.33
734.38
926.47
37


 


156
TEPTLNSAIPGDPR
15.33
734.38
1237.65
37


 


157
TEQTLNTAIPGDPR
14.47
756.89
940.48
38


 


158
TEQTLNTAIPGDPR
14.47
756.89
972.5
38


 


159
TEQTLNTAIPGDPR
14.47
756.89
1154.62
38


 


160
TESTLNTAIPGDPR
14.52
736.37
940.48
37


 


161
TESTLNTAIPGDPR
14.52
736.37
1053.57
37


 


162
TESTLNTAIPGDPR
14.52
736.37
1154.62
37


 


163
TETTLNTAIPGDPR
14.88
743.38
826.44
38


 


164
TETTLNTAIPGDPR
14.88
743.38
940.48
38


 


165
TETTLNTAIPGDPR
14.88
743.38
945.49
38


 


166
TGSC[CAM]DYGTTNDIAVIWPK
20.38
999.47
1055.59
49


 


167
TGSC[CAM]DYGTTNDIAVIWPK
20.38
999.47
1156.64
49


 


168
TGSC[CAM]DYGTTNDIAVIWPK
20.38
999.47
1172.42
49


 


169
TGSC[CAM]GYGTTNDIAVIWPK
20.21
970.46
1055.59
48


 


170
TGSC[CAM]GYGTTNDIAVIWPK
20.21
970.46
1114.41
48


 


171
TGSC[CAM]GYGTTNDIAVIWPK
20.21
970.46
1156.64
48


 


172
TGSGDYGTTNDIAVIWPEGR
20.27
1055
1069.41
51


 


173
TGSGDYGTTNDIAVIWPEGR
20.27
1055
1155.62
51


 


174
TGSGDYGTTNDIAVIWPEGR
20.27
1055
1182.49
51


 


175
TGSGGYGTTNDIAVIWPEGR
20.16
684.33
757.4
38


 


176
TGSGGYGTTNDIAVIWPEGR
20.16
684.33
927.5
38


 


177
TGSGGYGTTNDIAVIWPEGR
20.16
684.33
1011.4
38


 


178
TGSGGYGTTNDIAVIWPQGR
19.81
684
756.42
38


 


179
TGSGGYGTTNDIAVIWPQGR
19.81
684
926.52
38


 


180
TGSGGYGTTNDIAVIWPQGR
19.81
684
1011.4
38


 


181
TIGDDTFR
12.86
462.72
538.26
25


 


182
TIGDDTFR
12.86
462.72
653.29
25


 


183
TIGDDTFR
12.86
462.72
710.31
25


 


184
TQLVTWLK
19.07
494.79
646.39
27


 


185
TQLVTWLK
19.07
494.79
759.48
27


 


186
TQLVTWLK
19.07
494.79
887.53
27


 


187
VEIKPSDLINYNPIAEK
20.21
648.35
769.41
36


 


188
VEIKPSDLINYNPIAEK
20.21
648.35
882.49
36


 


189
VEIKPSDLINYNPIAEK
20.21
648.35
948.48
36


 


190
VEIKPSDLVNYNPIAEK
19.33
643.68
769.41
36


 


191
VEIKPSDLVNYNPIAEK
19.33
643.68
882.49
36


 


192
VEIKPSDLVNYNPIAEK
19.33
643.68
948.48
36


 


193
VIGDDTFR
13.3
461.73
538.26
25


 


194
VIGDDTFR
13.3
461.73
710.31
25


 


195
VIGDDTFR
13.3
461.73
823.39
25


 


196
VMAAAALLK
17.06
444.27
586.39
25


 


197
VMAAAALLK
17.06
444.27
657.43
25


 


198
VMAAAALLK
17.06
444.27
788.47
25


 


199
VMAAAAVLEQSETQK
16.62
788.41
962.48
40


 


200
VMAAAAVLEQSETQK
16.62
788.41
1061.55
40


 


201
VMAAAAVLEQSETQK
16.62
788.41
1132.58
40


 


202
WAKPSGAVGDVAQR
12.73
481.26
628.34
28


 


203
WAKPSGAVGDVAQR
12.73
481.26
645.33
28


 


204
WAKPSGAVGDVAQR
12.73
481.26
698.36
28









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 19
Identification of a Resistance to DHA Beta-Lactams
The samples corresponding to a species able to comprise a DHA resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 25 instead of the peptides from TABLE 3.












TABLE 25








(m/z)
(m/z)



Transition

Retention time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
ADLLHFYQQWQPSR
20.9
596.97
673.34
34


 


2
ADLLHFYQQWQPSR
20.9
596.97
988.49
34


 


3
ADLLHFYQQWQPSR
20.9
596.97
1116.55
34


 


4
AELLHFYQQWQPSR
19.23
601.64
673.34
34


 


5
AELLHFYQQWQPSR
19.23
601.64
801.4
34


 


6
AELLHFYQQWQPSR
19.23
601.64
1130.56
34


 


7
EMMLNDPAEK
13.78
589.26
786.4
31


 


8
EMMLNDPAEK
13.78
589.26
917.44
31


 


9
EMMLNDPAEK
13.78
589.26
1048.48
31


 


10
GKPYYFNYGFADVQAK
18.12
623.31
631.34
35


 


11
GKPYYFNYGFADVQAK
18.12
623.31
778.41
35


 


12
GKPYYFNYGFADVQAK
18.12
623.31
835.43
35


 


13
TAAINQGLGWEMYDWPQQK
21.57
746.02
964.45
41


 


14
TAAINQGLGWEMYDWPQQK
21.57
746.02
1095.49
41


 


15
TAAINQGLGWEMYDWPQQK
21.57
1118.53
1224.54
54


 


16
WAEMNIEPSR
15.85
616.79
715.37
32


 


17
WAEMNIEPSR
15.85
616.79
975.46
32


 


18
WAEMNIEPSR
15.85
616.79
1046.49
32









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 20
Identification of a Resistance to FOX Beta-Lactams
The samples corresponding to a species able to comprise a FOX resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 26 instead of the peptides from TABLE 3.












TABLE 26








(m/z)




Transition

Retention time
filtered in
(m/z) filtered
Collision


number
Peptide
(minutes)
Q1
in Q3
energy (eV)




















1
ATPGVLAAEAYGIK
17.72
680.88
751.4
35


 


2
ATPGVLAAEAYGIK
17.72
680.88
822.44
35


 


3
ATPGVLAAEAYGIK
17.72
680.88
935.52
35


 


4
FAEANMGYQGDAAVK
14.08
786.36
908.45
40


 


5
FAEANMGYQGDAAVK
14.08
786.36
1039.49
40


 


6
FAEANMGYQGDAAVK
14.08
786.36
1224.57
40


 


7
FAEANMGYQGDALVK
16.35
538.59
602.35
31


 


8
FAEANMGYQGDALVK
16.35
538.59
730.41
31


 


9
FAEANMGYQGDALVK
16.35
807.38
950.49
41


 


10
GEAPLTAAVDGIIQPMLK
25.85
912.5
1014.57
45


 


11
GEAPLTAAVDGIIQPMLK
25.85
912.5
1113.63
45


 


12
GEAPLTAAVDGIIQPMLK
25.85
912.5
1184.67
45


 


13
HWSPVYPAGTHR
12.55
469.9
541.28
27


 


14
HWSPVYPAGTHR
12.55
469.9
607.3
27


 


15
HWSPVYPAGTHR
12.55
469.9
638.34
27


 


16
IPGIAVAVLK
19.45
490.83
600.41
27


 


17
IPGIAVAVLK
19.45
490.83
770.51
27


 


18
IPGIAVAVLK
19.45
490.83
867.57
27


 


19
LMSQTLLPK
16.18
515.8
699.44
28


 


20
LMSQTLLPK
16.18
515.8
786.47
28


 


21
LMSQTLLPK
16.18
515.8
917.51
28


 


22
MQTYYR
10.72
431.2
602.29
24


 


23
MQTYYR
10.72
431.2
687.28
24


 


24
MQTYYR
10.72
431.2
730.35
24


 


25
VSHHAPWLK
11.49
537.8
614.37
29


 


26
VSHHAPWLK
11.49
537.8
751.42
29


 


27
VSHHAPWLK
11.49
537.8
888.48
29


 


28
VTPGMLAAEAYGIK
19
710.88
822.44
36


 


29
VTPGMLAAEAYGIK
19
710.88
1123.58
36


 


30
VTPGMLAAEAYGIK
19
710.88
1220.63
36









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 21
Identification of a Resistance to MIR Beta-Lactams
The samples corresponding to a species able to comprise an MIR resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 27 instead of the peptides from TABLE 3.












TABLE 27








(m/z)
(m/z)



Transition

Retention time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
AEEAHFAWGYR
16.38
446.21
568.77
20.9


 


2
AEEAHFAWGYR
16.36
446.21
633.29
20.9


 


3
AEEAHFAWGYR
16.36
446.21
652.32
20.9


 


4
DMASWLIANMKPDSLHAPSLK
24.18
775.73
811.44
31.1


 


5
DMASWLIANMKPDSLHAPSLK
24.18
775.73
867.98
31.1


 


6
DMASWLIANMKPDSLHAPSLK
24.18
775.73
1004.54
31.1


 


7
DMASWLIANMKPDSLQAPSLK
25.04
772.73
528.29
31


 


8
DMASWLIANMKPDSLQAPSLK
25.04
772.73
806.94
31


 


9
DMASWLIANMKPDSLQAPSLK
25.04
772.73
863.48
31


 


10
DMASWVIANMKPDSLQAPSLK
24
768.06
806.94
30.9


 


11
DMASWVIANMKPDSLQAPSLK
24
768.06
856.47
30.9


 


12
DMASWVIANMKPDSLQAPSLK
24
768.06
949.51
30.9


 


13
GEIALGDPVAK
15.79
535.3
586.32
26.2


 


14
GEIALGDPVAK
15.77
535.3
699.4
26.2


 


15
GEIALGDPVAK
15.77
535.3
770.44
26.2


 


16
TVVGGSDNK
3.35
438.73
520.24
20.7


 


17
TVVGGSDNK
3.35
438.73
577.26
20.7


 


18
TVVGGSDNK
3.35
438.73
676.33
20.7









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 22
Identification of a Resistance to SHV Beta-Lactams
The samples corresponding to a species able to comprise an SHV resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 28 instead of the peptides from TABLE 3.












TABLE 28








(m/z)
(m/z)



Transition

Retention time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
EIGDNVTR
10.07
452.23
489.28
25


 


2
EIGDNVTR
10.07
452.23
529.23
25


 


3
EIGDNVTR
10.07
452.23
661.33
25


 


4
GIVALLGPHNK
16.52
373.56
398.21
23


 


5
GIVALLGPHNK
16.52
373.56
552.29
23


 


6
GIVALLGPHNK
16.52
373.56
665.37
23


 


7
HLADGMTVGELR
14.93
433.56
474.27
26


 


8
HLADGMTVGELR
14.93
433.56
494.24
26


 


9
HLADGMTVGELR
14.93
433.56
573.34
26


 


10
IHYSQQDLVDYSPVSEK
16.22
669.99
872.39
37


 


11
IHYSQQDLVDYSPVSEK
16.22
669.99
924.43
37


 


12
IHYSQQDLVDYSPVSEK
16.22
669.99
985.47
37









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 23
Identification of a Resistance to CARB Beta-Lactams
The samples corresponding to a species able to comprise a CARB resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 29 instead of the peptides from TABLE 3.












TABLE 29








(m/z)
(m/z)



Transition

Retention time
filtered in
filtered in
Collision


number
Peptide
(minutes)
Q1
Q3
energy (eV)




















1
ADLVTYSPVIEK
17.48
667.86
672.39
34.4


 


2
ADLVTYSPVIEK
17.48
667.86
835.46
34.4


 


3
ADLVTYSPVIEK
17.48
667.86
936.5
34.4


 


4
ADLVTYSPVLEK
18.01
667.86
672.39
34.4


 


5
ADLVTYSPVLEK
18.01
667.86
835.46
34.4


 


6
ADLVTYSPVLEK
18.01
667.86
936.5
34.4


 


7
AIASTLNK
10.86
409.24
475.29
23


 


8
AIASTLNK
10.86
409.24
562.32
23


 


9
AIASTLNK
10.86
409.24
633.36
23


 


10
AIASTLNQLLFGSTLSEASQK
25.39
727.06
362.2
40.4


 


11
AIASTLNQLLFGSTLSEASQK
25.39
727.06
649.32
40.4


 


12
AIASTLNQLLFGSTLSEASQK
25.39
727.06
998.02
40.4


 


13
AIEVSLSAR
15.46
473.27
533.3
25.8


 


14
AIEVSLSAR
15.46
473.27
632.37
25.8


 


15
AIEVSLSAR
15.46
473.27
761.42
25.8


 


16
DTTTPIAMVTTLEK
21.41
507.6
591.34
29.4


 


17
DTTTPIAMVTTLEK
21.41
507.6
690.4
29.4


 


18
DTTTPIAMVTTLEK
21.41
507.6
892.48
29.4


 


19
DTTTPK
1.54
331.67
345.21
19.6


 


20
DTTTPK
1.54
331.67
446.26
19.6


 


21
DTTTPK
1.54
331.67
547.31
19.6


 


22
FLFGSALSEMNK
21.32
672.34
879.42
34.6


 


23
FLFGSALSEMNK
21.32
672.34
936.45
34.6


 


24
FLFGSALSEMNK
21.32
672.34
1083.51
34.6


 


25
FPLSSTFK
17.51
463.75
390.22
25.4


 


26
FPLSSTFK
17.51
463.75
682.38
25.4


 


27
FPLSSTFK
17.51
463.75
779.43
25.4


 


28
FPLTSTFK
17.85
470.76
397.23
25.7


 


29
FPLTSTFK
17.85
470.76
696.39
25.7


 


30
FPLTSTFK
17.85
470.76
793.45
25.7


 


31
FQQVEQDAK
10.02
546.77
590.28
29.1


 


32
FQQVEQDAK
10.02
546.77
689.35
29.1


 


33
FQQVEQDAK
10.02
546.77
817.41
29.1


 


34
FQQVEQDVK
11.76
560.79
618.31
29.7


 


35
FQQVEQDVK
11.76
560.79
717.38
29.7


 


36
FQQVEQDVK
11.76
560.79
845.44
29.7


 


37
FQSVEQEIK
14.17
554.29
745.41
29.4


 


38
FQSVEQEIK
14.17
554.29
832.44
29.4


 


39
FQSVEQEIK
14.17
554.29
960.5
29.4


 


40
FSESNLVTYSPVTEK
17.84
567.62
462.74
32.4


 


41
FSESNLVTYSPVTEK
17.84
567.62
777.39
32.4


 


42
FSESNLVTYSPVTEK
17.85
567.62
924.47
32.4


 


43
GIESSLSAR
12.88
460.25
533.3
25.3


 


44
GIESSLSAR
12.88
460.25
620.34
25.3


 


45
GIESSLSAR
12.88
460.25
749.38
25.3


 


46
GNEVGDALFR
17.15
539.27
678.36
28.7


 


47
GNEVGDALFR
17.15
539.27
777.43
28.7


 


48
GNEVGDALFR
17.15
539.27
906.47
28.7


 


49
GVPSDWIVADR
18.32
607.81
529.77
31.7


 


50
GVPSDWIVADR
18.32
607.81
759.42
31.7


 


51
GVPSDWIVADR
18.32
607.81
1058.53
31.7


 


52
GVTDFLR
17.69
404.22
326.18
22.8


 


53
GVTDFLR
17.69
404.22
550.3
22.8


 


54
GVTDFLR
17.69
404.22
651.35
22.8


 


55
IEPDLNEGK
12.13
507.76
386.7
27.3


 


56
IEPDLNEGK
12.13
507.76
772.38
27.3


 


57
IEPDLNEGK
12.13
507.76
901.43
27.3


 


58
IEPELNEGK
12.2
514.77
393.7
27.6


 


59
IEPELNEGK
12.2
514.77
786.4
27.6


 


60
IEPELNEGK
12.2
514.77
915.44
27.6


 


61
IGEQIAK
10.58
379.72
459.29
21.7


 


62
IGEQIAK
10.58
379.72
588.34
21.7


 


63
IGEQIAK
10.58
379.72
645.36
21.7


 


64
IGLAVHDLETGK
16.05
626.85
799.39
32.6


 


65
IGLAVHDLETGK
16.05
626.85
898.46
32.6


 


66
IGLAVHDLETGK
16.05
626.85
969.5
32.6


 


67
KPIVAALYITETDASFEER
21.09
718.38
667.31
39.9


 


68
KPIVAALYITETDASFEER
21.09
718.38
787.37
39.9


 


69
KPIVAALYITETDASFEER
21.09
718.38
853.37
39.9


 


70
LESWMVNNQVTGNLLR
22.01
625.32
564.81
32.5


 


71
LESWMVNNQVTGNLLR
22.01
625.32
673.4
32.5


 


72
LESWMVNNQVTGNLLR
22.01
625.32
772.47
32.5


 


73
LEYWMVNNQVTGNLLR
22.96
650.67
564.81
33.6


 


74
LEYWMVNNQVTGNLLR
22.96
650.67
673.4
33.6


 


75
LEYWMVNNQVTGNLLR
22.96
650.67
772.47
33.6


 


76
LLFGSALSEMNQK
21.03
719.37
389.21
36.7


 


77
LLFGSALSEMNQK
21.03
719.37
736.33
36.7


 


78
LLFGSALSEMNQK
21.03
719.37
1211.57
36.7


 


79
LLIDETLSIK
20.7
572.85
805.43
30.2


 


80
LLIDETLSIK
20.7
572.85
918.51
30.2


 


81
LLIDETLSIK
20.7
572.85
1031.6
30.2


 


82
LLYDAEHGK
11.75
523.27
656.3
28


 


83
LLYDAEHGK
11.75
523.27
819.36
28


 


84
LLYDAEHGK
11.75
523.27
932.45
28


 


85
LLYDAEQGEINPK
15.72
745.38
358.21
37.8


 


86
LLYDAEQGEINPK
15.72
745.38
632.3
37.8


 


87
LLYDAEQGEINPK
15.72
745.38
785.42
37.8


 


88
LLYDAEQGK
13.05
518.77
647.3
27.8


 


89
LLYDAEQGK
13.05
518.77
810.36
27.8


 


90
LLYDAEQGK
13.05
518.77
923.45
27.8


 


91
MCDNQNYGVTYMK
14.67
541.89
641.33
31.1


 


92
MCDNQNYGVTYMK
14.67
541.89
698.35
31.1


 


93
MCDNQNYGVTYMK
14.67
541.89
861.42
31.1


 


94
NAVIAK
7.68
308.2
331.23
18.6


 


95
NAVIAK
7.68
308.2
430.3
18.6


 


96
NAVIAK
7.68
308.2
501.34
18.6


 


97
NDAIVK
8.38
330.19
359.27
19.5


 


98
NDAIVK
8.38
330.19
430.3
19.5


 


99
NDAIVK
8.38
330.19
545.33
19.5


 


100
QQLESWLK
17.65
516.28
533.31
27.7


 


101
QQLESWLK
17.65
516.28
662.35
27.7


 


102
QQLESWLK
17.65
516.28
775.44
27.7


 


103
QVEQDVK
6.63
423.22
361.21
23.6


 


104
QVEQDVK
6.63
423.22
489.27
23.6


 


105
QVEQDVK
6.63
423.22
618.31
23.6


 


106
SGAGGFGAR
9.32
390.19
507.27
22.2


 


107
SGAGGFGAR
9.32
390.19
564.29
22.2


 


108
SGAGGFGAR
9.32
390.19
635.33
22.2


 


109
SIGDDTTR
7.76
432.71
492.24
24


 


110
SIGDDTTR
7.76
432.71
607.27
24


 


111
SIGDDTTR
7.76
432.71
664.29
24


 


112
SITAIVWSEEK
18.92
631.84
405.2
32.8


 


113
SITAIVWSEEK
18.92
631.84
777.38
32.8


 


114
SITAIVWSEEK
18.92
631.84
1062.55
32.8


 


115
SITDFLR
19.34
426.24
435.27
23.8


 


116
SITDFLR
19.34
426.24
550.3
23.8


 


117
SITDFLR
19.34
426.24
651.35
23.8


 


118
STIEIK
11.83
345.71
389.24
20.2


 


119
STIEIK
11.83
345.71
502.32
20.2


 


120
STIEIK
11.83
345.71
603.37
20.2


 


121
SVLPAGWNIADR
19.61
649.85
500.25
33.6


 


122
SVLPAGWNIADR
19.61
649.85
556.8
33.6


 


123
SVLPAGWNIADR
19.61
649.85
999.5
33.6


 


124
SVLPEGWNIADR
19.62
678.85
529.26
34.9


 


125
SVLPEGWNIADR
19.62
678.85
585.8
34.9


 


126
SVLPEGWNIADR
19.62
678.85
1057.51
34.9


 


127
SVLPVK
13.24
321.71
343.23
19.2


 


128
SVLPVK
13.24
321.71
456.32
19.2


 


129
SVLPVK
13.24
321.71
555.39
19.2


 


130
SVLPVTWSIADR
21.34
672.37
522.78
34.6


 


131
SVLPVTWSIADR
21.34
672.37
1044.55
34.6


 


132
SVLPVTWSIADR
21.34
672.37
1157.63
34.6


 


133
TGAGGYGSR
3.77
413.2
596.28
23.2


 


134
TGAGGYGSR
3.77
413.2
667.32
23.2


 


135
TGAGGYGSR
3.77
413.2
724.34
23.2


 


136
TIACAK
3.86
332.18
378.18
19.6


 


137
TIACAK
3.86
332.18
449.22
19.6


 


138
TIACAK
3.86
332.18
562.3
19.6


 


139
TILMENSR
13.19
482.25
505.24
26.2


 


140
TILMENSR
13.19
482.25
636.28
26.2


 


141
TILMENSR
13.19
482.25
749.36
26.2


 


142
TLACANVLQR
14.83
573.31
466.24
30.2


 


143
TLACANVLQR
14.83
573.31
860.44
30.2


 


144
TLACANVLQR
14.83
573.31
931.48
30.2


 


145
TVLMENSR
11.76
475.24
505.24
25.9


 


146
TVLMENSR
11.76
475.24
636.28
25.9


 


147
TVLMENSR
11.76
475.24
749.36
25.9


 


148
VEPELNEGK
11.18
507.76
393.7
27.3


 


149
VEPELNEGK
11.18
507.76
447.22
27.3


 


150
VEPELNEGK
11.18
507.76
560.3
27.3


 


151
VNLNSTVEIK
15.48
558.82
790.43
29.6


 


152
VNLNSTVEIK
15.48
558.82
903.52
29.6


 


153
VNLNSTVEIK
15.48
558.82
1017.56
29.6


 


154
VNLNSTVEVK
14.23
551.81
776.42
29.3


 


155
VNLNSTVEVK
14.23
551.81
889.5
29.3


 


156
VNLNSTVEVK
14.23
551.81
1003.54
29.3


 


157
VNPNSTVEIK
12.41
550.8
444.25
29.2


 


158
VNPNSTVEIK
12.41
550.8
887.48
29.2


 


159
VNPNSTVEIK
12.41
550.8
1001.53
29.2


 


160
VNSNSTVEIK
11.24
545.79
790.43
29


 


161
VNSNSTVEIK
11.24
545.79
877.46
29


 


162
VNSNSTVEIK
11.24
545.79
991.51
29


 


163
WETELNEAVPGDK
16.5
744.35
358.19
37.8


 


164
WETELNEAVPGDK
16.5
744.35
415.21
37.8


 


165
WETELNEAVPGDK
16.5
744.35
471.75
37.8


 


166
WSIADR
14.14
374.19
361.18
21.5


 


167
WSIADR
14.14
374.19
474.27
21.5


 


168
WSIADR
14.14
374.19
561.3
21.5









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 24
Identification of a Resistance to OXA Beta-Lactams
The samples corresponding to a species able to comprise an OXA resistance mechanism can be detected by employing the following method.
Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 30 instead of the peptides from TABLE 3.












TABLE 30







Retention
(m/z)
(m/z)
Collision


Transition

time
filtered in
filtered in
energy


number
Peptide
(minutes)
Q1
Q3
(eV)




















1
AAAYELAENLFEAGQADGWR
24.48
728.01
1249.6
40


 


2
AAAYELAENLFEAGQADGWR
24.48
1091.51
1193.58
53


 


3
AAAYELAENLFEAGQADGWR
24.48
1091.51
1249.6
53


 


4
AAEGFIPASTFK
17.74
619.82
763.43
32


 


5
AAEGFIPASTFK
17.74
619.82
910.5
32


 


6
AAEGFIPASTFK
17.74
619.82
967.52
32


 


7
ADGQVVAFALNMQMK
21.27
811.91
982.48
41


 


8
ADGQVVAFALNMQMK
21.29
811.91
1053.52
41


 


9
ADGQVVAFALNMQMK
21.27
811.91
1152.59
41


 


10
ADINEIFK
17.3
475.25
650.35
26


 


11
ADINEIFK
17.3
475.25
763.43
26


 


12
ADINEIFK
17.3
475.25
878.46
26


 


13
ADWGK
6.9
288.64
390.21
18


 


14
ADWGK
6.91
288.64
430.17
18


 


15
ADWGK
6.89
288.64
505.24
18


 


16
AEGAIVISDER
13.52
387.2
419.19
23


 


17
AEGAIVISDER
13.53
387.2
506.22
23


 


18
AEGAIVISDER
13.52
387.2
619.3
23


 


19
AFALNLDIDK
20.16
560.31
717.38
30


 


20
AFALNLDIDK
20.16
560.31
830.46
30


 


21
AFALNLDIDK
20.16
560.31
901.5
30


 


22
AFAPMSTFK
16.96
500.25
710.35
27


 


23
AFAPMSTFK
16.96
500.25
781.39
27


 


24
AFAPMSTFK
16.96
500.25
928.46
27


 


25
AFGYGNADVSGDPGQNNGLDR
15.12
708.65
873.42
39


 


26
AFGYGNADVSGDPGQNNGLDR
15.12
708.65
970.47
39


 


27
AFGYGNADVSGDPGQNNGLDR
15.12
708.65
1154.47
39


 


28
AFTMTK
11.32
349.68
480.25
20


 


29
AFTMTK
11.33
349.68
552.25
20


 


30
AFTMTK
11.33
349.68
627.32
20


 


31
AGDDIALR
12.23
415.72
587.35
23


 


32
AGDDIALR
12.23
415.72
702.38
23


 


33
AGDDIALR
12.23
415.72
759.4
23


 


34
AGHVYAFALNIDMPR
20.63
558.95
631.32
32


 


35
AGHVYAFALNIDMPR
20.63
558.95
745.37
32


 


36
AGHVYAFALNIDMPR
20.63
558.95
817.4
32


 


37
AGLWR
13.44
301.67
361.2
18


 


38
AGLWR
13.44
301.67
474.28
18


 


39
AGLWR
13.44
301.67
531.3
18


 


40
AHTEYVPASTFK
13.18
450.89
553.3
27


 


41
AHTEYVPASTFK
13.18
450.89
602.26
27


 


42
AHTEYVPASTFK
13.18
450.89
650.35
27


 


43
AIIPWDGKPR
15.84
384.89
428.23
23


 


44
AIIPWDGKPR
15.84
384.89
457.29
23


 


45
AIIPWDGKPR
15.84
384.89
572.32
23


 


46
AISDITITR
14.8
495.28
603.38
27


 


47
AISDITITR
14.8
495.28
718.41
27


 


48
AISDITITR
14.8
495.28
805.44
27


 


49
ALGQDR
11.25
330.18
475.23
20


 


50
ALGQDR
11.25
330.18
485.24
20


 


51
ALGQDR
11.25
330.18
588.31
20


 


52
ALQAK
1.86
265.67
346.21
17


 


53
ALQAK
1.87
265.67
384.22
17


 


54
ALQAK
1.87
265.67
459.29
17


 


55
AMETFSPASTFK
17.06
658.81
737.38
34


 


56
AMETFSPASTFK
17.05
658.81
985.5
34


 


57
AMETFSPASTFK
17.06
658.81
1114.54
34


 


58
AMLFLQER
18.48
504.27
545.3
27


 


59
AMLFLQER
18.48
504.27
692.37
27


 


60
AMLFLQER
18.48
504.27
805.46
27


 


61
AMLVFDPVR
19.87
524.29
732.4
28


 


62
AMLVFDPVR
19.87
524.29
845.49
28


 


63
AMLVFDPVR
19.87
524.29
976.53
28


 


64
AMTLLESGPGWELHGK
19.32
575.96
923.47
33


 


65
AMTLLESGPGWELHGK
19.32
575.96
980.49
33


 


66
AMTLLESGPGWELHGK
19.32
575.96
1067.53
33


 


67
ANLHITLHGK
12.18
368.55
403.24
22


 


68
ANLHITLHGK
12.18
368.55
555.32
22


 


69
ANLHITLHGK
12.18
368.55
668.41
22


 


70
ANQLIVK
11.87
393.25
600.41
22


 


71
ANQLIVK
11.86
393.25
639.38
22


 


72
ANQLIVK
11.86
393.25
714.45
22


 


73
ANTEYVPASTFK
14.54
664.33
912.48
34


 


74
ANTEYVPASTFK
14.54
664.33
1041.53
34


 


75
ANTEYVPASTFK
14.54
664.33
1142.57
34


 


76
ANVSR
9.57
273.65
361.22
17


 


77
ANVSR
9.57
273.65
372.19
17


 


78
ANVSR
9.57
273.65
475.26
17


 


79
APIGWFIGWATR
25.58
687.87
850.46
35


 


80
APIGWFIGWATR
25.58
687.87
1093.56
35


 


81
APIGWFIGWATR
25.58
687.87
1206.64
35


 


82
APLGWFIGWATHEER
24.69
590.63
742.35
34


 


83
APLGWFIGWATHEER
24.69
590.63
985.45
34


 


84
APLGWFIGWATHEER
24.69
590.63
1098.53
34


 


85
AQDEVQSMLFIEEK
20.15
833.9
996.51
42


 


86
AQDEVQSMLFIEEK
20.14
833.9
1124.57
42


 


87
AQDEVQSMLFIEEK
20.15
833.9
1223.63
42


 


88
AQGVIVLWNENK
18.95
685.87
902.47
35


 


89
AQGVIVLWNENK
18.95
685.87
1015.56
35


 


90
AQGVIVLWNENK
18.95
685.87
1171.65
35


 


91
ASAIAVYQDLAR
18.05
639.35
765.39
33


 


92
ASAIAVYQDLAR
18.05
639.35
864.46
33


 


93
ASAIAVYQDLAR
18.05
639.35
935.49
33


 


94
ASAILVYQDLAR
19.08
660.37
765.39
34


 


95
ASAILVYQDLAR
19.08
660.37
864.46
34


 


96
ASAILVYQDLAR
19.08
660.37
977.54
34


 


97
ASAIPVYQDLAR
17.45
652.35
765.39
34


 


98
ASAIPVYQDLAR
17.45
652.35
864.46
34


 


99
ASAIPVYQDLAR
17.45
652.35
961.51
34


 


100
ASAIPVYQDLPR
17.59
665.36
791.4
34


 


101
ASAIPVYQDLPR
17.59
665.36
890.47
34


 


102
ASAIPVYQDLPR
17.6
665.36
987.53
34


 


103
ASAIQVYQDLAR
18.37
667.86
765.39
34


 


104
ASAIQVYQDLAR
18.37
667.86
864.46
34


 


105
ASAIQVYQDLAR
18.37
667.86
992.52
34


 


106
ASAISVYQDLAR
17.93
647.34
765.39
33


 


107
ASAISVYQDLAR
17.93
647.34
864.46
33


 


108
ASAISVYQDLAR
17.93
647.34
951.49
33


 


109
ASALPVYQDLAR
17.77
652.35
864.46
34


 


110
ASALPVYQDLAR
17.77
652.35
961.51
34


 


111
ASALPVYQDLAR
17.77
652.35
1074.59
34


 


112
ASAMPVYQDLAR
16.64
661.33
765.39
34


 


113
ASAMPVYQDLAR
16.64
661.33
864.46
34


 


114
ASAMPVYQDLAR
16.64
661.33
961.51
34


 


115
ASAVPVYQDLAR
16.29
645.35
765.39
33


 


116
ASAVPVYQDLAR
16.29
645.35
864.46
33


 


117
ASAVPVYQDLAR
16.29
645.35
961.51
33


 


118
ASIEYVPASTFK
16.7
656.84
749.42
34


 


119
ASIEYVPASTFK
16.7
656.84
912.48
34


 


120
ASIEYVPASTFK
16.7
656.84
1041.53
34


 


121
ASNVPVYQELAR
18.48
673.86
779.4
35


 


122
ASNVPVYQELAR
18.48
673.86
878.47
35


 


123
ASNVPVYQELAR
18.48
673.86
975.53
35


 


124
ASPASTFK
10.29
404.71
553.3
23


 


125
ASPASTFK
10.29
404.71
650.35
23


 


126
ASPASTFK
10.28
404.71
737.38
23


 


127
ASTAYIPASTFK
15.69
628.83
763.43
33


 


128
ASTAYIPASTFK
15.69
628.83
926.5
33


 


129
ASTAYIPASTFK
15.69
628.83
997.54
33


 


130
ASTEYVPASTFK
14.59
650.82
749.42
34


 


131
ASTEYVPASTFK
14.59
650.82
912.48
34


 


132
ASTEYVPASTFK
14.6
650.82
1041.53
34


 


133
ASTTEVFK
11.78
441.73
623.34
24


 


134
ASTTEVFK
11.78
441.73
724.39
24


 


135
ASTTEVFK
11.78
441.73
811.42
24


 


136
ATSTEIFK
13.15
448.74
637.36
25


 


137
ATSTEIFK
13.15
448.74
724.39
25


 


138
ATSTEIFK
13.15
448.74
825.44
25


 


139
ATTNEIFK
13.21
462.25
650.35
25


 


140
ATTNEIFK
13.21
462.25
751.4
25


 


141
ATTNEIFK
13.21
462.25
852.45
25


 


142
ATTTAVFK
11.9
419.74
464.29
23


 


143
ATTTAVFK
11.9
419.74
565.33
23


 


144
ATTTAVFK
11.9
419.74
666.38
23


 


145
ATTTEIFK
13.64
455.75
637.36
25


 


146
ATTTEIFK
13.65
455.75
738.4
25


 


147
ATTTEIFK
13.65
455.75
839.45
25


 


148
ATTTEVFK
11.98
448.74
623.34
25


 


149
ATTTEVFK
11.98
448.74
724.39
25


 


150
ATTTEVFK
11.98
448.74
825.44
25


 


151
AVSDITILEQTDNYTLHGK
19.19
706.7
974.49
39


 


152
AVSDITILEQTDNYTLHGK
19.19
706.7
1048.51
39


 


153
AVSDITILEQTDNYTLHGK
19.18
706.7
1176.56
39


 


154
AVSDITILEQTYNYTLHGK
22.29
722.71
995.49
40


 


155
AVSDITILEQTYNYTLHGK
22.29
722.71
998.5
40


 


156
AVSDITILEQTYNYTLHGK
22.28
722.71
1224.6
40


 


157
AVVPHFEAGDWDVQGK
17.81
585.62
743.34
33


 


158
AVVPHFEAGDWDVQGK
17.81
585.62
792.88
33


 


159
AVVPHFEAGDWDVQGK
17.81
585.62
904.42
33


 


160
AWEHDMSLR
13.99
572.76
758.36
30


 


161
AWEHDMSLR
13.99
572.76
887.4
30


 


162
AWEHDMSLR
13.99
572.76
1073.48
30


 


163
AWIGSSLQISPLEQLEFLGK
26.98
739.4
963.51
41


 


164
AWIGSSLQISPLEQLEFLGK
26.99
739.4
1173.65
41


 


165
AWIGSSLQISPLEQLEFLGK
26.98
1108.6
1173.65
54


 


166
DAFLK
12.42
297.17
407.27
18


 


167
DAFLK
12.43
297.17
447.22
18


 


168
DAFLK
12.42
297.17
478.3
18


 


169
DDFILHGK
13.99
472.75
714.43
26


 


170
DDFILHGK
13.99
472.75
798.38
26


 


171
DDFILHGK
13.99
472.75
829.46
26


 


172
DDVLK
8.62
295.16
359.27
18


 


173
DDVLK
8.63
295.16
443.21
18


 


174
DDVLK
8.62
295.16
474.29
18


 


175
DEFHVFR
15.39
475.23
705.38
26


 


176
DEFHVFR
15.39
475.23
775.34
26


 


177
DEFHVFR
15.39
475.23
834.43
26


 


178
DEFQIFR
19.02
477.74
520.2
26


 


179
DEFQIFR
19.02
477.74
563.33
26


 


180
DEFQIFR
19.02
477.74
710.4
26


 


181
DEFQVFR
17.29
470.73
549.31
26


 


182
DEFQVFR
17.28
470.73
619.27
26


 


183
DEFQVFR
17.29
470.73
696.38
26


 


184
DELVR
9.33
316.17
387.27
19


 


185
DELVR
9.35
316.17
457.23
19


 


186
DELVR
9.33
316.17
516.31
19


 


187
DFDYGNQDFSGDK
14.72
754.3
967.41
38


 


188
DFDYGNQDFSGDK
14.72
754.3
1130.47
38


 


189
DFDYGNQDFSGDK
14.72
754.3
1245.5
38


 


190
DFTLGEAMQASTVPVYQELAR
24.19
776.05
975.53
43


 


191
DFTLGEAMQASTVPVYQELAR
24.19
776.05
1074.59
43


 


192
DFTLGEAMQASTVPVYQELAR
24.19
1163.57
1175.64
56


 


193
DHDLITAMK
14.23
522.26
563.32
28


 


194
DHDLITAMK
14.23
522.26
695.34
28


 


195
DHDLITAMK
14.23
522.26
791.43
28


 


196
DIAAWNR
13.63
423.22
546.28
24


 


197
DIAAWNR
13.63
423.22
617.32
24


 


198
DIAAWNR
13.62
423.22
730.4
24


 


199
DILYIQELAGGWK
24.49
753.4
888.46
38


 


200
DILYIQELAGGWK
24.48
753.4
1001.54
38


 


201
DILYIQELAGGWK
24.49
753.4
1164.6
38


 


202
DITILEK
15.9
416.24
603.37
23


 


203
DITILEK
15.91
416.24
685.38
23


 


204
DITILEK
15.91
416.24
716.46
23


 


205
DLLSAK
12.45
323.69
429.23
19


 


206
DLLSAK
12.44
323.69
500.27
19


 


207
DLLSAK
12.45
323.69
531.35
19


 


208
DLMITEAGR
15.07
503.26
533.27
27


 


209
DLMITEAGR
15.07
503.26
646.35
27


 


210
DLMITEAGR
15.07
503.26
777.39
27


 


211
DLMIVEAGR
16.68
502.27
531.29
27


 


212
DLMIVEAGR
16.68
502.27
644.37
27


 


213
DLMIVEAGR
16.68
502.27
775.41
27


 


214
DLMIVEAK
16.23
459.75
473.24
25


 


215
DLMIVEAK
16.23
459.75
559.34
25


 


216
DLMIVEAK
16.23
459.75
690.39
25


 


217
DLSGNPGK
6.69
394.2
472.25
22


 


218
DLSGNPGK
6.69
394.2
559.28
22


 


219
DLSGNPGK
6.7
394.2
672.37
22


 


220
DLSLR
12.37
302.18
375.24
18


 


221
DLSLR
12.35
302.18
429.23
18


 


222
DLSLR
12.36
302.18
488.32
18


 


223
DLTLR
12.48
309.18
389.25
19


 


224
DLTLR
12.47
309.18
443.25
19


 


225
DLTLR
12.47
309.18
502.33
19


 


226
DMTLGDAIK
15.97
482.24
503.28
26


 


227
DMTLGDAIK
15.97
482.24
616.37
26


 


228
DMTLGDAIK
15.97
482.24
717.41
26


 


229
DMTLGDAMALSAVPVYQELAR
25.76
751.04
975.53
42


 


230
DMTLGDAMALSAVPVYQELAR
25.76
1126.06
1145.63
55


 


231
DMTLGDAMALSAVPVYQELAR
25.75
1126.06
1232.66
55


 


232
DMTLGDAMK
14.46
491.22
634.32
27


 


233
DMTLGDAMK
14.46
491.22
735.37
27


 


234
DMTLGDAMK
14.46
491.22
866.41
27


 


235
DMTLGEAMALSAVPVYQDLAR
25.92
751.04
961.51
42


 


236
DMTLGEAMALSAVPVYQDLAR
25.92
1126.06
1131.62
55


 


237
DMTLGEAMALSAVPVYQDLAR
25.92
1126.06
1218.65
55


 


238
DMTLGEAMALSAVPVYQELAR
26.48
755.71
779.4
42


 


239
DMTLGEAMALSAVPVYQELAR
26.48
755.71
975.53
42


 


240
DMTLGEAMALSAVPVYQELAR
26.47
1133.07
1232.66
55


 


241
DMTLGEAMK
15.09
498.23
535.25
27


 


242
DMTLGEAMK
15.09
498.23
648.34
27


 


243
DMTLGEAMK
15.09
498.23
749.39
27


 


244
DMTLGQAMQASAVPVYQELAR
23.29
760.38
779.4
42


 


245
DMTLGQAMQASAVPVYQELAR
23.29
760.38
975.53
42


 


246
DMTLGQAMQASAVPVYQELAR
23.29
760.38
976.42
42


 


247
DQDLR
2.54
323.66
403.23
19


 


248
DQDLR
2.55
323.66
472.2
19


 


249
DQDLR
2.55
323.66
531.29
19


 


250
DQQIGWFVGWASKPGK
21.64
601.98
830.45
34


 


251
DQQIGWFVGWASKPGK
21.64
902.46
929.52
45


 


252
DQQIGWFVGWASKPGK
21.64
902.46
1076.59
45


 


253
DQQVQVYGNDLNR
13.59
774.87
851.4
39


 


254
DQQVQVYGNDLNR
13.58
774.87
950.47
39


 


255
DQQVQVYGNDLNR
13.59
774.87
1078.53
39


 


256
DQTLESAFK
15.21
519.76
581.29
28


 


257
DQTLESAFK
15.21
519.76
694.38
28


 


258
DQTLESAFK
15.21
519.76
795.42
28


 


259
DSIVWYSQELTR
19.61
748.87
896.45
38


 


260
DSIVWYSQELTR
19.61
748.87
1082.53
38


 


261
DSIVWYSQELTR
19.61
748.87
1181.59
38


 


262
DSIVWYSQQLTR
19.1
748.38
895.46
38


 


263
DSIVWYSQQLTR
19.11
748.38
1081.54
38


 


264
DSIVWYSQQLTR
19.1
748.38
1180.61
38


 


265
DSNLR
1.77
302.66
402.25
18


 


266
DSNLR
1.77
302.66
430.19
18


 


267
DSNLR
1.77
302.66
489.28
18


 


268
DSYIAWGGEAWK
19.67
691.82
833.39
35


 


269
DSYIAWGGEAWK
19.67
691.82
904.43
35


 


270
DSYIAWGGEAWK
19.66
691.82
1017.52
35


 


271
DTLNPEWPYK
17.3
631.81
819.4
33


 


272
DTLNPEWPYK
17.3
631.81
933.45
33


 


273
DTLNPEWPYK
17.3
631.81
1046.53
33


 


274
DVDEVFYK
15.62
507.74
685.36
27


 


275
DVDEVFYK
15.62
507.74
800.38
27


 


276
DVDEVFYK
15.62
507.74
899.45
27


 


277
DWILR
17.44
351.7
415.2
20


 


278
DWILR
17.44
351.7
528.28
20


 


279
DWILR
17.44
351.7
587.37
20


 


280
EAFLR
12.51
318.18
435.27
19


 


281
EAFLR
12.51
318.18
461.24
19


 


282
EAFLR
12.51
318.18
506.31
19


 


283
EAIVR
7.84
294.18
387.27
18


 


284
EAIVR
7.84
294.18
413.24
18


 


285
EAIVR
7.84
294.18
458.31
18


 


286
EAIVTEATPEYIVHSK
16.43
596.31
746.42
34


 


287
EAIVTEATPEYIVHSK
16.43
596.31
972.51
34


 


288
EAIVTEATPEYIVHSK
16.42
596.31
1073.56
34


 


289
EALVTEAAPEYLVHSK
17.3
586.31
875.46
33


 


290
EALVTEAAPEYLVHSK
17.3
586.31
972.51
33


 


291
EALVTEAAPEYLVHSK
17.3
586.31
1114.59
33


 


292
EALVTEAPEYLVHSK
17.58
562.63
637.32
32


 


293
EALVTEAPEYLVHSK
17.58
562.63
972.51
32


 


294
EALVTEAPEYLVHSK
17.58
562.63
1043.55
32


 


295
EEIVR
8.41
323.18
387.27
19


 


296
EEIVR
8.4
323.18
471.24
19


 


297
EEIVR
8.4
323.18
516.31
19


 


298
EEVLAALPAQLK
19.48
641.37
740.47
33


 


299
EEVLAALPAQLK
19.47
641.37
811.5
33


 


300
EEVLAALPAQLK
19.47
641.37
924.59
33


 


301
EFSAEAVNGVFVLC[CAM]K
21.1
835.42
936.5
42


 


302
EFSAEAVNGVFVLC[CAM]K
21.1
835.42
1106.6
42


 


303
EFSAEAVNGVFVLC[CAM]K
21.1
835.42
1235.65
42


 


304
EFSSESVHGVFVLC[CAM]K
18.26
575.62
666.36
33


 


305
EFSSESVHGVFVLC[CAM]K
18.26
575.62
822.45
33


 


306
EFSSESVHGVFVLC[CAM]K
18.26
575.62
959.51
33


 


307
EGMSGSIR
9.88
418.7
432.26
23


 


308
EGMSGSIR
9.88
418.7
519.29
23


 


309
EGMSGSIR
9.88
418.7
707.35
23


 


310
EGMTGSIR
10.63
425.71
432.26
24


 


311
EGMTGSIR
10.63
425.71
533.3
24


 


312
EGMTGSIR
10.63
425.71
664.34
24


 


313
EIAVWNR
14.78
444.24
475.24
25


 


314
EIAVWNR
14.77
444.24
574.31
25


 


315
EIAVWNR
14.77
444.24
645.35
25


 


316
EIAYK
8.46
312.17
381.21
19


 


317
EIAYK
8.46
312.17
477.23
19


 


318
EIAYK
8.46
312.17
494.3
19


 


319
EIFER
11.7
347.18
451.23
20


 


320
EIFER
11.7
347.18
519.24
20


 


321
EIFER
11.7
347.18
564.31
20


 


322
EIFYHYR
13.31
514.25
785.37
28


 


323
EIFYHYR
13.31
514.25
853.39
28


 


324
EIFYHYR
13.32
514.25
898.46
28


 


325
EIGDDK
1.99
338.66
434.19
20


 


326
EIGDDK
1.99
338.66
530.21
20


 


327
EIGDDK
1.99
338.66
547.27
20


 


328
EIGDGK
1.76
309.66
376.18
19


 


329
EIGDGK
1.75
309.66
472.2
19


 


330
EIGDGK
1.75
309.66
489.27
19


 


331
EIGEDK
2.32
345.67
448.2
20


 


332
EIGEDK
2.33
345.67
544.22
20


 


333
EIGEDK
2.33
345.67
561.29
20


 


334
EIGEDNAR
10.05
452.21
604.27
25


 


335
EIGEDNAR
10.05
452.21
661.29
25


 


336
EIGEDNAR
10.06
452.21
774.37
25


 


337
EIGENK
1.86
345.18
447.22
20


 


338
EIGENK
1.86
345.18
543.24
20


 


339
EIGENK
1.86
345.18
560.3
20


 


340
EIGSEIDK
11.04
445.73
591.3
25


 


341
EIGSEIDK
11.04
445.73
648.32
25


 


342
EIGSEIDK
11.04
445.73
761.4
25


 


343
EMIYLK
15.11
398.72
536.34
23


 


344
EMIYLK
15.11
398.72
650.32
23


 


345
EMIYLK
15.11
398.72
667.38
23


 


346
EMLYVER
14.12
470.23
566.29
26


 


347
EMLYVER
14.12
470.23
679.38
26


 


348
EMLYVER
14.12
470.23
810.42
26


 


349
ENIEK
11.07
316.67
389.24
19


 


350
ENIEK
11.07
316.67
486.22
19


 


351
ENIEK
11.07
316.67
503.28
19


 


352
ENQLIVK
12.15
422.25
472.35
24


 


353
ENQLIVK
12.15
422.25
600.41
24


 


354
ENQLIVK
12.15
422.25
714.45
24


 


355
EQAILLFR
19.88
495.29
548.36
27


 


356
EQAILLFR
19.88
495.29
661.44
27


 


357
EQAILLFR
19.88
495.29
732.48
27


 


358
EQIQFLLR
19.45
523.8
548.36
28


 


359
EQIQFLLR
19.45
523.8
676.41
28


 


360
EQIQFLLR
19.45
523.8
789.5
28


 


361
EQLAFDPQVQQQVK
16.43
829.43
954.54
41


 


362
EQLAFDPQVQQQVK
16.42
829.43
1069.56
41


 


363
EQLAFDPQVQQQVK
16.42
829.43
1216.63
41


 


364
EQVDFVQR
13.09
510.76
549.31
27


 


365
EQVDFVQR
13.09
510.76
664.34
27


 


366
EQVDFVQR
13.09
510.76
763.41
27


 


367
EVGEIR
9.35
351.69
474.27
20


 


368
EVGEIR
9.35
351.69
528.27
20


 


369
EVGEIR
9.35
351.69
573.34
20


 


370
EVGEVR
6.91
344.68
460.25
20


 


371
EVGEVR
6.91
344.68
514.25
20


 


372
EVGEVR
6.91
344.68
559.32
20


 


373
EYLPASTFK
15.41
528.27
553.3
28


 


374
EYLPASTFK
15.41
528.27
650.35
28


 


375
EYLPASTFK
15.41
528.27
763.43
28


 


376
EYLPVSTFK
17.16
542.29
581.33
29


 


377
EYLPVSTFK
17.16
542.29
678.38
29


 


378
EYLPVSTFK
17.16
542.29
791.47
29


 


379
EYNTSGTFVFYDGK
18.2
814.37
1033.5
41


 


380
EYNTSGTFVFYDGK
18.2
814.37
1120.53
41


 


381
EYNTSGTFVFYDGK
18.2
814.37
1221.58
41


 


382
EYVPASTFK
13.89
521.27
553.3
28


 


383
EYVPASTFK
13.89
521.27
650.35
28


 


384
EYVPASTFK
13.89
521.27
749.42
28


 


385
FAPESTFK
13.67
463.73
482.26
25


 


386
FAPESTFK
13.67
463.73
611.3
25


 


387
FAPESTFK
13.67
463.73
708.36
25


 


388
FAQYAK
9.39
364.19
509.27
21


 


389
FAQYAK
9.39
364.19
580.31
21


 


390
FAQYAK
9.39
364.19
581.27
21


 


391
FDYGNR
10.1
386.17
509.25
22


 


392
FDYGNR
10.1
386.17
597.23
22


 


393
FDYGNR
10.09
386.17
624.27
22


 


394
FEDLYK
13.52
407.7
423.26
23


 


395
FEDLYK
13.52
407.7
538.29
23


 


396
FEDLYK
13.52
407.7
667.33
23


 


397
FEDTFHISNQK
14.33
455.89
476.25
27


 


398
FEDTFHISNQK
14.33
455.89
589.33
27


 


399
FEDTFHISNQK
14.33
455.89
726.39
27


 


400
FEDTFHTSNQQHEK
10.66
583.26
870.41
33


 


401
FEDTFHTSNQQHEK
10.66
583.26
971.45
33


 


402
FEDTFHTSNQQHEK
10.66
583.26
1108.51
33


 


403
FEYGNQDVSGDSGK
11.95
751.82
764.34
38


 


404
FEYGNQDVSGDSGK
11.95
751.82
1063.47
38


 


405
FEYGNQDVSGDSGK
11.95
751.82
1226.53
38


 


406
FFSDFQAK
16
495.24
608.3
27


 


407
FFSDFQAK
16
495.24
695.34
27


 


408
FFSDFQAK
16
495.24
842.4
27


 


409
FFSDLQAEGAIVIADER
20.44
627.65
1143.6
35


 


410
FFSDLQAEGAIVIADER
20.43
940.97
1143.6
46


 


411
FFSDLQAEGAIVIADER
20.44
940.97
1179.57
46


 


412
FFSDLR
15.38
392.7
490.26
22


 


413
FFSDLR
15.38
392.7
610.29
22


 


414
FFSDLR
15.38
392.7
637.33
22


 


415
FFSEFQAK
16.13
502.25
622.32
27


 


416
FFSEFQAK
16.13
502.25
709.35
27


 


417
FFSEFQAK
16.13
502.25
856.42
27


 


418
FGLEGQLR
15.8
460.25
473.28
25


 


419
FGLEGQLR
15.8
460.25
602.33
25


 


420
FGLEGQLR
15.8
460.25
772.43
25


 


421
FLESLYLNNLPASK
20.75
804.94
856.49
40


 


422
FLESLYLNNLPASK
20.75
804.94
1019.55
40


 


423
FLESLYLNNLPASK
20.75
804.94
1219.67
40


 


424
FLLEGQLR
18.06
488.28
602.33
26


 


425
FLLEGQLR
18.06
488.28
715.41
26


 


426
FLLEGQLR
18.06
488.28
828.49
26


 


427
FQQYVDR
11.19
478.24
552.28
26


 


428
FQQYVDR
11.19
478.24
680.34
26


 


429
FQQYVDR
11.19
478.24
808.39
26


 


430
FSDYVQR
11.83
457.72
565.31
25


 


431
FSDYVQR
11.83
457.72
680.34
25


 


432
FSDYVQR
11.83
457.72
767.37
25


 


433
FSTASTFK
12.71
444.73
553.3
25


 


434
FSTASTFK
12.7
444.73
654.35
25


 


435
FSTASTFK
12.7
444.73
741.38
25


 


436
FSWDGK
14.32
370.17
505.24
21


 


437
FSWDGK
14.32
370.17
592.27
21


 


438
FSWDGK
14.32
370.17
593.24
21


 


439
FSYGNQNISGGIDK
14.61
750.36
803.43
38


 


440
FSYGNQNISGGIDK
14.61
750.36
1045.53
38


 


441
FSYGNQNISGGIDK
14.61
750.36
1102.55
38


 


442
FSYGNQNISGGTDK
12.74
744.34
791.39
38


 


443
FSYGNQNISGGTDK
12.74
744.34
1033.49
38


 


444
FSYGNQNISGGTDK
12.74
744.34
1090.51
38


 


445
FSYGSQNISGGIDK
14.74
736.85
803.43
37


 


446
FSYGSQNISGGIDK
14.74
736.85
1075.54
37


 


447
FSYGSQNISGGIDK
14.75
736.85
1238.6
37


 


448
FTEYVK
11.81
393.71
538.29
22


 


449
FTEYVK
11.81
393.71
639.33
22


 


450
FTEYVK
11.81
393.71
640.3
22


 


451
FVPASTYK
11.76
456.74
498.26
25


 


452
FVPASTYK
11.76
456.74
569.29
25


 


453
FVPASTYK
11.77
456.74
666.35
25


 


454
FVYDLAQGQLPFKPEVQQQVK
20.48
821.44
955.52
45


 


455
FVYDLAQGQLPFKPEVQQQVK
20.48
821.44
1108.59
45


 


456
FVYDLAQGQLPFKPEVQQQVK
20.49
821.44
1109.07
45


 


457
FWLEDQLR
20.39
553.79
660.33
29


 


458
FWLEDQLR
20.39
553.79
773.42
29


 


459
FWLEDQLR
20.38
553.79
959.49
29


 


460
FWLEGPLK
20.63
495.28
543.31
27


 


461
FWLEGPLK
20.63
495.28
656.4
27


 


462
FWLEGPLK
20.63
495.28
842.48
27


 


463
FWLEGQLR
19.49
524.78
602.33
28


 


464
FWLEGQLR
19.49
524.78
715.41
28


 


465
FWLEGQLR
19.48
524.78
901.49
28


 


466
FYPASSFK
14.74
473.74
636.34
26


 


467
FYPASSFK
14.74
473.74
799.4
26


 


468
FYPASSFK
14.74
473.74
800.36
26


 


469
FYPASTFK
14.98
480.74
553.3
26


 


470
FYPASTFK
14.99
480.74
650.35
26


 


471
FYPASTFK
14.98
480.74
813.41
26


 


472
GAIQVSAVPVFQQIAR
21.6
842.48
958.55
42


 


473
GAIQVSAVPVFQQIAR
21.6
842.48
1057.62
42


 


474
GAIQVSAVPVFQQIAR
21.59
842.48
1128.65
42


 


475
GAIQVSAVPVFQQITR
21.52
857.49
988.56
43


 


476
GAIQVSAVPVFQQITR
21.51
857.49
1087.63
43


 


477
GAIQVSAVPVFQQITR
21.52
857.49
1158.66
43


 


478
GELPVSEDALEMTK
18.1
759.87
936.43
38


 


479
GELPVSEDALEMTK
18.11
759.87
1023.47
38


 


480
GELPVSEDALEMTK
18.11
759.87
1122.53
38


 


481
GISSSVR
8.65
353.2
448.25
21


 


482
GISSSVR
8.65
353.2
535.28
21


 


483
GISSSVR
8.67
353.2
648.37
21


 


484
GNQTLVFAR
14.83
503.28
605.38
27


 


485
GNQTLVFAR
14.83
503.28
706.42
27


 


486
GNQTLVFAR
14.83
503.28
834.48
27


 


487
GPLEISAFEEAR
18.95
659.84
809.38
34


 


488
GPLEISAFEEAR
18.94
659.84
922.46
34


 


489
GPLEISAFEEAR
18.94
659.84
1051.51
34


 


490
GPLTITPIQEVK
18.14
648.38
814.47
34


 


491
GPLTITPIQEVK
18.15
648.38
927.55
34


 


492
GPLTITPIQEVK
18.14
648.38
1028.6
34


 


493
GSLLLWDQK
19.61
530.3
576.28
28


 


494
GSLLLWDQK
19.61
530.3
689.36
28


 


495
GSLLLWDQK
19.61
530.3
802.45
28


 


496
GTFVLYDVQR
17.93
599.32
680.34
31


 


497
GTFVLYDVQR
17.93
599.32
793.42
31


 


498
GTFVLYDVQR
17.93
599.32
892.49
31


 


499
GTIVVADER
11.82
480.26
490.23
26


 


500
GTIVVADER
11.82
480.26
589.29
26


 


501
GTIVVADER
11.82
480.26
688.36
26


 


502
GTIVVLDAR
15.77
472.28
573.34
26


 


503
GTIVVLDAR
15.77
472.28
672.4
26


 


504
GTIVVLDAR
15.77
472.28
785.49
26


 


505
GTIVVVDER
13.6
494.28
518.26
27


 


506
GTIVVVDER
13.6
494.28
617.33
27


 


507
GTIVVVDER
13.6
494.28
716.39
27


 


508
GTLPFSAR
14.96
424.73
577.31
24


 


509
GTLPFSAR
14.96
424.73
690.39
24


 


510
GTLPFSAR
14.97
424.73
791.44
24


 


511
HIADSK
11.91
335.68
420.21
20


 


512
HIADSK
11.9
335.68
524.25
20


 


513
HIADSK
11.91
335.68
533.29
20


 


514
HNGTDGAWIISSLR
19.36
509.6
575.35
29


 


515
HNGTDGAWIISSLR
19.35
509.6
653.26
29


 


516
HNGTDGAWIISSLR
19.36
509.6
688.44
29


 


517
HTLSVFDQER
14.25
411.21
432.22
25


 


518
HTLSVFDQER
14.25
411.21
547.25
25


 


519
HTLSVFDQER
14.25
411.21
694.32
25


 


520
HVTFASFR
14.36
322.17
338.18
20


 


521
HVTFASFR
14.36
322.17
409.22
20


 


522
HVTFASFR
14.36
322.17
485.25
20


 


523
IAISLMGYDAGFLR
23.93
763.91
898.44
39


 


524
IAISLMGYDAGFLR
23.93
763.91
1029.48
39


 


525
IAISLMGYDAGFLR
23.94
763.91
1229.6
39


 


526
IALSLMGFDSGILK
24.91
732.91
836.45
37


 


527
IALSLMGFDSGILK
24.91
732.91
967.49
37


 


528
IALSLMGFDSGILK
24.91
732.91
1167.61
37


 


529
IANALIGLENHK
15.95
431.58
697.36
26


 


530
IANALIGLENHK
15.95
646.87
697.36
33


 


531
IANALIGLENHK
15.95
646.87
810.45
33


 


532
IDTFWLDNSLK
21.79
676.35
689.38
35


 


533
IDTFWLDNSLK
21.79
676.35
875.46
35


 


534
IDTFWLDNSLK
21.79
676.35
1123.58
35


 


535
IDYYNLDR
14.85
536.26
680.34
29


 


536
IDYYNLDR
14.85
536.26
843.4
29


 


537
IDYYNLDR
14.85
536.26
958.43
29


 


538
IFNALIALDSGVIK
24.74
737.44
802.47
37


 


539
IFNALIALDSGVIK
24.74
737.44
915.55
37


 


540
IFNALIALDSGVIK
24.74
737.44
1028.64
37


 


541
IFNSLLALDSGALDNER
22.76
924.48
976.43
46


 


542
IFNSLLALDSGALDNER
22.77
924.48
1089.52
46


 


543
IFNSLLALDSGALDNER
22.76
924.48
1160.55
46


 


544
IFNTLIGLENGIVK
23.29
765.95
829.48
39


 


545
IFNTLIGLENGIVK
23.3
765.95
942.56
39


 


546
IFNTLIGLENGIVK
23.3
765.95
1055.65
39


 


547
IGLDLMQK
17.7
459.26
634.32
25


 


548
IGLDLMQK
17.7
459.26
747.41
25


 


549
IGLDLMQK
17.7
459.26
804.43
25


 


550
IGLEK
8.54
280.18
389.24
17


 


551
IGLEK
8.55
280.18
413.24
17


 


552
IGLEK
8.54
280.18
446.26
17


 


553
IGLELMQQEVQR
18.73
722.38
787.41
37


 


554
IGLELMQQEVQR
18.73
722.38
918.45
37


 


555
IGLELMQQEVQR
18.73
722.38
1031.53
37


 


556
IGLELMSK
17.52
445.75
478.27
25


 


557
IGLELMSK
17.52
445.75
720.4
25


 


558
IGLELMSK
17.52
445.75
777.42
25


 


559
IGLELMSNEVK
18.73
616.83
707.34
32


 


560
IGLELMSNEVK
18.73
616.83
820.42
32


 


561
IGLELMSNEVK
18.73
616.83
949.47
32


 


562
IGLER
10.96
294.18
304.16
18


 


563
IGLER
10.96
294.18
417.25
18


 


564
IGLER
10.96
294.18
474.27
18


 


565
IGLNK
9.59
272.68
374.24
17


 


566
IGLNK
9.59
272.68
398.24
17


 


567
IGLNK
9.59
272.68
431.26
17


 


568
IGLNLMQK
17.1
458.77
633.34
25


 


569
IGLNLMQK
17.09
458.77
746.42
25


 


570
IGLNLMQK
17.11
458.77
803.44
25


 


571
IGPSLMQSELQR
17.02
679.86
760.39
35


 


572
IGPSLMQSELQR
17.02
679.86
891.44
35


 


573
IGPSLMQSELQR
17.02
679.86
1188.6
35


 


574
IGYGNMQIGTEVDQFWLK
24.31
700.35
935.5
39


 


575
IGYGNMQIGTEVDQFWLK
24.32
1050.02
1164.54
51


 


576
IGYGNMQIGTEVDQFWLK
24.3
1050.02
1222.61
51


 


577
IINHNLPVK
11.88
349.88
456.32
21


 


578
IINHNLPVK
11.88
349.88
570.36
21


 


579
IINHNLPVK
11.88
349.88
592.32
21


 


580
IINHNLPVR
12.04
359.22
598.37
22


 


581
IINHNLPVR
12.04
538.32
598.37
29


 


582
IINHNLPVR
12.04
538.32
849.47
29


 


583
ILFQQGTQQAC[CAM]AER
14.51
550.61
606.27
32


 


584
ILFQQGTQQAC[CAM]AER
14.51
825.41
1020.45
41


 


585
ILFQQGTQQAC[CAM]AER
14.51
825.41
1148.51
41


 


586
ILNNWFK
18.98
467.76
594.3
26


 


587
ILNNWFK
18.98
467.76
708.35
26


 


588
ILNNWFK
18.97
467.76
821.43
26


 


589
ILNTLISLEEK
19.98
636.87
718.4
33


 


590
ILNTLISLEEK
19.98
636.87
1046.57
33


 


591
ILNTLISLEEK
19.98
636.87
1159.66
33


 


592
INIVK
11.43
293.7
359.27
18


 


593
INIVK
11.43
293.7
440.29
18


 


594
INIVK
11.43
293.7
473.31
18


 


595
INLYGNALSR
16.05
560.81
617.34
30


 


596
INLYGNALSR
16.05
560.81
780.4
30


 


597
INLYGNALSR
16.05
560.81
893.48
30


 


598
IPFSLNLEMK
21.68
596.33
834.44
31


 


599
IPFSLNLEMK
21.67
596.33
981.51
31


 


600
IPFSLNLEMK
21.67
596.33
1078.56
31


 


601
IPHTLFALDADAVR
20
513.62
531.29
30


 


602
IPHTLFALDADAVR
20
513.62
646.32
30


 


603
IPHTLFALDADAVR
20
769.92
1191.64
39


 


604
IPHTLFALDAGAAR
18.58
726.9
744.4
37


 


605
IPHTLFALDAGAAR
18.58
726.9
891.47
37


 


606
IPHTLFALDAGAAR
18.58
726.9
1004.55
37


 


607
IPHTLFALDAGAVR
19.72
494.28
588.31
29


 


608
IPHTLFALDAGAVR
19.71
494.28
780.44
29


 


609
IPHTLFALDAGAVR
19.72
740.92
1133.63
38


 


610
IPNAIIGLETGVIK
21.75
719.44
816.48
37


 


611
IPNAIIGLETGVIK
21.75
719.44
929.57
37


 


612
IPNAIIGLETGVIK
21.75
719.44
1227.73
37


 


613
IPNALIGLETGAIK
20.96
705.42
788.45
36


 


614
IPNALIGLETGAIK
20.96
705.42
901.54
36


 


615
IPNALIGLETGAIK
20.96
705.42
1014.62
36


 


616
IPNSLIAFDTGAVR
20.24
737.41
765.39
37


 


617
IPNSLIAFDTGAVR
20.24
737.41
836.43
37


 


618
IPNSLIAFDTGAVR
20.24
737.41
949.51
37


 


619
IPSAIIGLETGVIK
21.66
705.93
816.48
36


 


620
IPSAIIGLETGVIK
21.67
705.93
929.57
36


 


621
IPSAIIGLETGVIK
21.66
705.93
1200.72
36


 


622
ISAFNQVK
13.02
453.76
488.28
25


 


623
ISAFNQVK
13.02
453.76
706.39
25


 


624
ISAFNQVK
13.02
453.76
793.42
25


 


625
ISAHEQILFLR
18.28
442.92
548.36
26


 


626
ISAHEQILFLR
18.28
442.92
789.5
26


 


627
ISAHEQILFLR
18.28
663.88
918.54
34


 


628
ISAMEQTR
9.84
468.23
664.31
26


 


629
ISAMEQTR
9.84
468.23
735.35
26


 


630
ISAMEQTR
9.84
468.23
822.38
26


 


631
ISAMEQVK
11.65
453.24
634.32
25


 


632
ISAMEQVK
11.65
453.24
705.36
25


 


633
ISAMEQVK
11.65
453.24
792.39
25


 


634
ISATEQVAFLR
17.7
412.23
435.27
25


 


635
ISATEQVAFLR
17.71
412.23
506.31
25


 


636
ISATEQVAFLR
17.7
412.23
605.38
25


 


637
ISATQQIAFLR
18.58
624.36
747.45
32


 


638
ISATQQIAFLR
18.58
624.36
1047.59
32


 


639
ISATQQIAFLR
18.58
624.36
1134.63
32


 


640
ISAVNQVEFLESLFLNK
28.77
976.03
988.51
48


 


641
ISAVNQVEFLESLFLNK
28.77
976.03
1110.62
48


 


642
ISAVNQVEFLESLFLNK
28.77
976.03
1239.66
48


 


643
ISAVNQVK
10.32
429.76
488.28
24


 


644
ISAVNQVK
10.32
429.76
658.39
24


 


645
ISAVNQVK
10.32
429.76
745.42
24


 


646
ISPEEQIQFLR
18.87
680.37
933.52
35


 


647
ISPEEQIQFLR
18.87
680.37
1062.56
35


 


648
ISPEEQIQFLR
18.87
680.37
1159.61
35


 


649
ISPEEQVR
10.49
479.25
531.29
26


 


650
ISPEEQVR
10.49
479.25
660.33
26


 


651
ISPEEQVR
10.49
479.25
757.38
26


 


652
ISPEGQVR
9.86
443.24
459.27
25


 


653
ISPEGQVR
9.86
443.24
588.31
25


 


654
ISPEGQVR
9.86
443.24
685.36
25


 


655
ISPLEQLAFLR
24.02
643.88
876.49
33


 


656
ISPLEQLAFLR
24.01
643.88
989.58
33


 


657
ISPLEQLAFLR
24.02
643.88
1086.63
33


 


658
ITAFQQVDFLR
21.11
669.36
777.43
34


 


659
ITAFQQVDFLR
21.12
669.36
905.48
34


 


660
ITAFQQVDFLR
21.12
669.36
1123.59
34


 


661
ITPIQEVNFADDFANNR
21.25
655.32
736.34
37


 


662
ITPIQEVNFADDFANNR
21.25
655.32
851.36
37


 


663
ITPIQEVNFADDFANNR
21.25
655.32
922.4
37


 


664
ITPIQEVNFADDLANNR
20.95
643.99
817.38
36


 


665
ITPIQEVNFADDLANNR
20.95
965.49
1149.53
47


 


666
ITPIQEVNFADDLANNR
20.96
965.49
1248.6
47


 


667
ITPQQEAQFAYK
14.52
712.36
856.42
36


 


668
ITPQQEAQFAYK
14.52
712.36
984.48
36


 


669
ITPQQEAQFAYK
14.52
712.36
1209.59
36


 


670
ITPQQEAQFTYK
14.33
485.25
558.29
28


 


671
ITPQQEAQFTYK
14.33
727.37
1014.49
37


 


672
ITPQQEAQFTYK
14.33
727.37
1239.6
37


 


673
ITPVQEVNFADDLAHNR
18.98
646.99
840.4
36


 


674
ITPVQEVNFADDLAHNR
18.98
646.99
862.92
36


 


675
ITPVQEVNFADDLAHNR
18.98
646.99
911.43
36


 


676
IVAFALK
17.21
381.25
478.3
22


 


677
IVAFALK
17.22
381.25
549.34
22


 


678
IVAFALK
17.21
381.25
648.41
22


 


679
IVAFALNMEMR
17.95
647.84
864.41
34


 


680
IVAFALNMEMR
17.95
647.84
1011.48
34


 


681
IVAFALNMEMR
17.97
647.84
1082.51
34


 


682
IVESTTLADGTVVHGK
13.69
542.96
697.4
31


 


683
IVESTTLADGTVVHGK
13.69
542.96
812.43
31


 


684
IVESTTLADGTVVHGK
13.68
542.96
883.46
31


 


685
IYNSLIGLNEK
17.37
632.35
673.39
33


 


686
IYNSLIGLNEK
17.37
632.35
786.47
33


 


687
IYNSLIGLNEK
17.37
632.35
987.55
33


 


688
KPDIGWWVGWIER
24.47
547.96
660.35
31


 


689
KPDIGWWVGWIER
24.47
547.96
883.45
31


 


690
KPDIGWWVGWIER
24.46
821.43
1188.59
41


 


691
LAC[CAM]ATNNLAR
11.22
552.28
688.37
29


 


692
LAC[CAM]ATNNLAR
11.22
552.28
759.41
29


 


693
LAC[CAM]ATNNLAR
11.22
552.28
919.44
29


 


694
LAQGELPFPAPVQSTVR
19.84
905.5
954.54
45


 


695
LAQGELPFPAPVQSTVR
19.84
905.5
1101.61
45


 


696
LAQGELPFPAPVQSTVR
19.84
905.5
1198.66
45


 


697
LAQNELPYPIEIQK
19.09
828.45
929.47
41


 


698
LAQNELPYPIEIQK
19.09
828.45
987.55
41


 


699
LAQNELPYPIEIQK
19.08
828.45
1100.64
41


 


700
LAQNELQYPIEIQK
17.98
843.96
890.5
42


 


701
LAQNELQYPIEIQK
17.98
843.96
1018.56
42


 


702
LAQNELQYPIEIQK
17.98
843.96
1131.64
42


 


703
LDFGNK
11.75
347.18
465.25
20


 


704
LDFGNK
11.74
347.18
547.25
20


 


705
LDFGNK
11.75
347.18
580.27
20


 


706
LDGSLNR
9.48
387.71
402.25
22


 


707
LDGSLNR
9.48
387.71
546.3
22


 


708
LDGSLNR
9.48
387.71
661.33
22


 


709
LEILQQALAELGLYPK
29.81
900.02
1003.58
45


 


710
LEILQQALAELGLYPK
29.81
900.02
1074.62
45


 


711
LEILQQALAELGLYPK
29.81
900.02
1202.68
45


 


712
LENQEQVK
7.6
494.26
631.34
27


 


713
LENQEQVK
7.59
494.26
745.38
27


 


714
LENQEQVK
7.59
494.26
874.43
27


 


715
LETQEEVEK
9.88
552.77
633.31
29


 


716
LETQEEVEK
9.88
552.77
862.42
29


 


717
LETQEEVEK
9.88
552.77
991.46
29


 


718
LETQEEVK
9.5
488.25
504.27
26


 


719
LETQEEVK
9.49
488.25
733.37
26


 


720
LETQEEVK
9.49
488.25
862.42
26


 


721
LFAAEGVK
13.53
417.74
503.28
23


 


722
LFAAEGVK
13.53
417.74
574.32
23


 


723
LFAAEGVK
13.53
417.74
721.39
23


 


724
LFESAGVK
12.99
425.74
461.27
24


 


725
LFESAGVK
12.99
425.74
590.31
24


 


726
LFESAGVK
12.99
425.74
737.38
24


 


727
LFGAAGVK
13.94
381.73
445.28
22


 


728
LFGAAGVK
13.94
381.73
502.3
22


 


729
LFGAAGVK
13.94
381.73
649.37
22


 


730
LGVDR
8.51
280.16
290.15
17


 


731
LGVDR
8.51
280.16
389.21
17


 


732
LGVDR
8.5
280.16
446.24
17


 


733
LLNLLSQSK
17.97
508.31
562.32
27


 


734
LLNLLSQSK
17.97
508.31
789.45
27


 


735
LLNLLSQSK
17.97
508.31
902.53
27


 


736
LLQDER
9.34
387.21
547.25
22


 


737
LLQDER
9.31
387.21
599.3
22


 


738
LLQDER
9.34
387.21
660.33
22


 


739
LLVQDGDC[CAM]GR
11.92
566.77
679.25
30


 


740
LLVQDGDC[CAM]GR
11.92
566.77
807.3
30


 


741
LLVQDGDC[CAM]GR
11.92
566.77
906.37
30


 


742
LNEVGYGNR
10.74
511.26
566.27
27


 


743
LNEVGYGNR
10.74
511.26
665.34
27


 


744
LNEVGYGNR
10.73
511.26
794.38
27


 


745
LNYGNADPSTK
10.76
590.29
732.35
31


 


746
LNYGNADPSTK
10.76
590.29
789.37
31


 


747
LNYGNADPSTK
10.76
590.29
952.44
31


 


748
LNYGNK
7.21
354.69
481.24
21


 


749
LNYGNK
7.24
354.69
562.26
21


 


750
LNYGNK
7.22
354.69
595.28
21


 


751
LPASK
1.93
258.16
305.18
16


 


752
LPASK
1.93
258.16
369.21
16


 


753
LPASK
1.93
258.16
402.23
16


 


754
LPHTLFALDADAVR
19.98
769.92
977.51
39


 


755
LPHTLFALDADAVR
19.98
769.92
1090.59
39


 


756
LPHTLFALDADAVR
19.98
769.92
1191.64
39


 


757
LPHTLFALDAGAVR
19.7
740.92
919.5
38


 


758
LPHTLFALDAGAVR
19.67
740.92
1032.58
38


 


759
LPHTLFALDAGAVR
19.7
740.92
1133.63
38


 


760
LPLAIMGFDSGILQSPK
25.08
893.99
944.5
44


 


761
LPLAIMGFDSGILQSPK
25.08
893.99
1091.57
44


 


762
LPLAIMGFDSGILQSPK
25.08
893.99
1148.59
44


 


763
LPLAIMGYDADILLDATTPR
27.86
720.39
773.42
40


 


764
LPLAIMGYDADILLDATTPR
27.87
720.39
886.5
40


 


765
LPLAIMGYDADILLDATTPR
27.87
720.39
1160.57
40


 


766
LPSSLIALETGAVR
20.6
713.92
816.46
36


 


767
LPSSLIALETGAVR
20.6
713.92
929.54
36


 


768
LPSSLIALETGAVR
20.6
713.92
1216.69
36


 


769
LPVSAQTLQYTANILK
21.84
880.5
950.53
44


 


770
LPVSAQTLQYTANILK
21.84
880.5
1063.61
44


 


771
LPVSAQTLQYTANILK
21.85
880.5
1164.66
44


 


772
LPVSER
9.57
350.7
490.26
20


 


773
LPVSER
9.57
350.7
526.29
20


 


774
LPVSER
9.57
350.7
587.31
20


 


775
LPVSPTAVDMTER
16.21
708.36
1019.48
36


 


776
LPVSPTAVDMTER
16.21
708.36
1106.51
36


 


777
LPVSPTAVDMTER
16.21
708.36
1205.58
36


 


778
LSASK
10.72
253.15
305.18
16


 


779
LSASK
10.71
253.15
359.19
16


 


780
LSASK
10.71
253.15
392.21
16


 


781
LSAVPIYQEVAR
17.96
673.38
765.39
35


 


782
LSAVPIYQEVAR
17.96
673.38
975.53
35


 


783
LSAVPIYQEVAR
17.95
673.38
1074.59
35


 


784
LSAVPVYQELAR
18.45
449.25
616.34
26


 


785
LSAVPVYQELAR
18.44
673.38
779.4
35


 


786
LSAVPVYQELAR
18.44
673.38
975.53
35


 


787
LSC[CAM]TLVIDEASGDLLHR
20.38
633.66
797.43
36


 


788
LSC[CAM]TLVIDEASGDLLHR
20.38
633.66
868.46
36


 


789
LSC[CAM]TLVIDEASGDLLHR
20.38
633.66
1112.53
36


 


790
LSLQHGWFIGWIEK
23.95
571.98
632.34
33


 


791
LSLQHGWFIGWIEK
23.95
571.98
892.49
33


 


792
LSLQHGWFIGWIEK
23.95
571.98
969.49
33


 


793
LSQNSLPFSQEAMNSVK
18.64
627.31
1140.54
35


 


794
LSQNSLPFSQEAMNSVK
18.63
940.46
1140.54
46


 


795
LSQNSLPFSQEAMNSVK
18.64
940.46
1237.59
46


 


796
LSVNPK
9.8
329.2
457.28
19


 


797
LSVNPK
9.79
329.2
511.29
19


 


798
LSVNPK
9.8
329.2
544.31
19


 


799
LTVGAR
9.51
308.69
402.25
19


 


800
LTVGAR
9.51
308.69
442.27
19


 


801
LTVGAR
9.51
308.69
503.29
19


 


802
LYGFALNIDMPGGEADIGK
23.35
661
843.42
37


 


803
LYGFALNIDMPGGEADIGK
23.35
990.99
1089.49
49


 


804
LYGFALNIDMPGGEADIGK
23.35
990.99
1202.57
49


 


805
LYHNELPFR
15.29
396.88
414.21
24


 


806
LYHNELPFR
15.29
396.88
419.24
24


 


807
LYHNELPFR
15.29
396.88
657.3
24


 


808
LYHNK
8.54
337.68
414.21
20


 


809
LYHNK
8.53
337.68
528.26
20


 


810
LYHNK
8.53
337.68
561.28
20


 


811
LYQNDLPFR
17.2
583.3
761.39
31


 


812
LYQNDLPFR
17.2
583.3
889.45
31


 


813
LYQNDLPFR
17.2
583.3
1052.52
31


 


814
MDDLFK
15.5
384.68
522.29
22


 


815
MDDLFK
15.5
384.68
622.25
22


 


816
MDDLFK
15.5
384.68
637.32
22


 


817
MEDLHK
6.66
386.69
512.28
22


 


818
MEDLHK
6.65
386.69
626.26
22


 


819
MEDLHK
6.66
386.69
641.33
22


 


820
MLIALIGLENHK
21.33
451.26
527.26
27


 


821
MLIALIGLENHK
21.33
451.26
697.36
27


 


822
MLIALIGLENHK
21.33
451.26
810.45
27


 


823
MLLIK
15.81
309.21
373.28
19


 


824
MLLIK
15.81
309.21
471.3
19


 


825
MLLIK
15.81
309.21
486.36
19


 


826
MLNALIGLEHHK
16.89
459.26
550.27
27


 


827
MLNALIGLEHHK
16.89
459.26
720.38
27


 


828
MLNALIGLEHHK
16.89
459.26
833.46
27


 


829
MLNALIGLENHK
18.39
451.58
697.36
27


 


830
MLNALIGLENHK
18.38
676.87
697.36
35


 


831
MLNALIGLENHK
18.39
676.87
810.45
35


 


832
MLNALIGLENQK
19.71
672.37
688.36
35


 


833
MLNALIGLENQK
19.71
672.37
801.45
35


 


834
MLNALIGLENQK
19.71
672.37
914.53
35


 


835
MLNALIGLEYHK
19.6
701.38
746.38
36


 


836
MLNALIGLEYHK
19.6
701.38
859.47
36


 


837
MLNALIGLEYHK
19.6
701.38
1157.63
36


 


838
MLNALIGLQHGK
17.5
432.25
582.34
26


 


839
MLNALIGLQHGK
17.5
432.25
639.36
26


 


840
MLNALIGLQHGK
17.5
432.25
752.44
26


 


841
MLNALISLEHHK
17.2
352.2
359.17
21


 


842
MLNALISLEHHK
17.21
469.26
750.39
27


 


843
MLNALISLEHHK
17.2
469.26
863.47
27


 


844
MQAYVDAFDYGNR
17.56
775.34
957.41
39


 


845
MQAYVDAFDYGNR
17.56
775.34
1056.47
39


 


846
MQAYVDAFDYGNR
17.56
775.34
1219.54
39


 


847
MQEGLNK
8.68
410.21
560.3
23


 


848
MQEGLNK
8.66
410.21
673.3
23


 


849
MQEGLNK
8.68
410.21
688.36
23


 


850
MSPASTYK
9.49
442.71
569.29
24


 


851
MSPASTYK
9.49
442.71
666.35
24


 


852
MSPASTYK
9.49
442.71
753.38
24


 


853
NEHDPVLPYR
13.09
413.88
435.24
25


 


854
NEHDPVLPYR
13.09
620.31
744.44
32


 


855
NEHDPVLPYR
13.09
620.31
859.47
32


 


856
NEHQIFK
9.91
458.24
509.21
25


 


857
NEHQIFK
9.91
458.24
622.29
25


 


858
NEHQIFK
9.91
458.24
672.38
25


 


859
NEHQVFK
7.74
451.23
658.37
25


 


860
NEHQVFK
7.74
451.23
755.35
25


 


861
NEHQVFK
7.74
451.23
787.41
25


 


862
NEITYK
9.35
384.2
524.31
22


 


863
NEITYK
9.35
384.2
621.29
22


 


864
NEITYK
9.35
384.2
653.35
22


 


865
NELLMK
13.08
374.21
504.32
21


 


866
NELLMK
13.09
374.21
601.3
21


 


867
NELLMK
13.09
374.21
633.36
21


 


868
NELPFR
14.39
388.21
419.24
22


 


869
NELPFR
14.39
388.21
532.32
22


 


870
NELPFR
14.4
388.21
661.37
22


 


871
NISSYGNNLVR
14.36
618.82
835.44
32


 


872
NISSYGNNLVR
14.36
618.82
922.47
32


 


873
NISSYGNNLVR
14.36
618.82
1009.51
32


 


874
NISTYGNNLTR
13.1
626.82
674.36
33


 


875
NISTYGNNLTR
13.09
626.82
837.42
33


 


876
NISTYGNNLTR
13.1
626.82
1025.5
33


 


877
NLFNEVHTTGVLVIR
20.69
571.32
757.49
33


 


878
NLFNEVHTTGVLVIR
20.7
571.32
858.54
33


 


879
NLFNEVHTTGVLVIR
20.7
571.32
995.6
33


 


880
NLSTYGNALAR
14.34
590.31
764.4
31


 


881
NLSTYGNALAR
14.35
590.31
865.45
31


 


882
NLSTYGNALAR
14.35
590.31
952.48
31


 


883
NMENLELFGK
19.08
597.79
820.46
31


 


884
NMENLELFGK
19.08
597.79
949.5
31


 


885
NMENLELFGK
19.08
597.79
1080.54
31


 


886
NMLLLEENNGYK
16.71
719.36
853.37
37


 


887
NMLLLEENNGYK
16.69
719.36
966.45
37


 


888
NMLLLEENNGYK
16.68
719.36
1079.54
37


 


889
NMLLLEESNGYK
18.12
705.85
939.44
36


 


890
NMLLLEESNGYK
18.13
705.85
1052.53
36


 


891
NMLLLEESNGYK
18.11
705.85
1165.61
36


 


892
NMLLLEK
16.99
430.75
502.32
24


 


893
NMLLLEK
16.98
430.75
615.41
24


 


894
NMLLLEK
16.98
430.75
746.45
24


 


895
NMTLGDAMK
14.42
490.73
521.24
27


 


896
NMTLGDAMK
14.42
490.73
634.32
27


 


897
NMTLGDAMK
14.42
490.73
735.37
27


 


898
NNGLTEAWLESSLK
20.61
781.4
862.47
39


 


899
NNGLTEAWLESSLK
20.6
781.4
933.5
39


 


900
NNGLTEAWLESSLK
20.62
781.4
1163.59
39


 


901
NQLPFK
13.49
373.71
391.23
21


 


902
NQLPFK
13.49
373.71
504.32
21


 


903
NQLPFK
13.49
373.71
632.38
21


 


904
NQLPFQVEHQR
14.33
698.36
796.41
36


 


905
NQLPFQVEHQR
14.33
698.36
1040.53
36


 


906
NQLPFQVEHQR
14.33
698.36
1153.61
36


 


907
NSAIENTIDNMYLQDLENSTK
22.77
805.04
934.45
44


 


908
NSAIENTIDNMYLQDLENSTK
22.77
805.04
1047.53
44


 


909
NSAIENTIDNMYLQDLENSTK
22.77
805.04
1210.6
44


 


910
NSAIENTIENMYLQDLDNSTK
23.13
805.04
920.43
44


 


911
NSAIENTIENMYLQDLDNSTK
23.13
805.04
1033.52
44


 


912
NSAIENTIENMYLQDLDNSTK
23.14
805.04
1196.58
44


 


913
NSAIENTIENMYLQDLENSTK
23.7
809.72
934.45
44


 


914
NSAIENTIENMYLQDLENSTK
23.7
809.72
1047.53
44


 


915
NSAIENTIENMYLQDLENSTK
23.7
809.72
1217.55
44


 


916
NSAVWVYELFAK
24.66
713.87
869.48
36


 


917
NSAVWVYELFAK
24.66
713.87
1055.56
36


 


918
NSAVWVYELFAK
24.65
713.87
1154.62
36


 


919
NSQVPAYK
9.78
453.74
478.27
25


 


920
NSQVPAYK
9.78
453.74
577.33
25


 


921
NSQVPAYK
9.78
453.74
705.39
25


 


922
NSTVWIYELFAK
25.64
735.88
883.49
37


 


923
NSTVWIYELFAK
25.64
735.88
1069.57
37


 


924
NSTVWIYELFAK
25.64
735.88
1168.64
37


 


925
NSTVWVYELFAK
24.42
728.88
770.41
37


 


926
NSTVWVYELFAK
24.43
728.88
869.48
37


 


927
NSTVWVYELFAK
24.42
728.88
1055.56
37


 


928
NSTVWVYQLFAK
23.9
728.39
769.42
37


 


929
NSTVWVYQLFAK
23.91
728.39
1054.57
37


 


930
NSTVWVYQLFAK
23.91
728.39
1153.64
37


 


931
NTSGALVIQTDK
13.34
623.84
816.48
32


 


932
NTSGALVIQTDK
13.34
623.84
944.54
32


 


933
NTSGALVIQTDK
13.34
623.84
1031.57
32


 


934
NTSGVLVIQTDK
14.9
637.85
816.48
33


 


935
NTSGVLVIQTDK
14.9
637.85
972.57
33


 


936
NTSGVLVIQTDK
14.91
637.85
1059.6
33


 


937
NVDEMFYYYDGSK
18.86
815.84
895.38
41


 


938
NVDEMFYYYDGSK
18.86
815.84
1042.45
41


 


939
NVDEMFYYYDGSK
18.85
815.84
1173.49
41


 


940
NWILR
16.3
351.21
414.21
20


 


941
NWILR
16.29
351.21
527.3
20


 


942
NWILR
16.3
351.21
587.37
20


 


943
NWNAAMDLR
16.54
545.76
605.31
29


 


944
NWNAAMDLR
16.55
545.76
676.34
29


 


945
NWNAAMDLR
16.54
545.76
790.39
29


 


946
NYVDAFHYGNQDISGDK
15.76
648.29
933.43
36


 


947
NYVDAFHYGNQDISGDK
15.77
648.29
1096.49
36


 


948
NYVDAFHYGNQDISGDK
15.76
971.93
1233.55
48


 


949
QADHAILVFDQAR
16.58
495.26
523.23
29


 


950
QADHAILVFDQAR
16.61
495.26
636.31
29


 


951
QADHAILVFDQAR
16.58
495.26
735.38
29


 


952
QAEHALLVFGQER
16.86
499.93
636.31
29


 


953
QAEHALLVFGQER
16.85
499.93
735.38
29


 


954
QAEHALLVFGQER
16.87
499.93
763.41
29


 


955
QAITK
11
280.67
361.24
17


 


956
QAITK
11
280.67
414.23
17


 


957
QAITK
11.01
280.67
432.28
17


 


958
QAMLTEANSDYIIR
18.26
812.9
951.49
41


 


959
QAMLTEANSDYIIR
18.25
812.9
1080.53
41


 


960
QAMLTEANSDYIIR
18.26
812.9
1181.58
41


 


961
QEVQFVSALAR
17.69
624.34
763.45
32


 


962
QEVQFVSALAR
17.68
624.34
891.5
32


 


963
QEVQFVSALAR
17.68
624.34
990.57
32


 


964
QFASIK
11.66
347.2
434.2
20


 


965
QFASIK
11.66
347.2
547.29
20


 


966
QFASIK
11.68
347.2
565.33
20


 


967
QGMPGSIR
11.4
423.22
529.31
24


 


968
QGMPGSIR
11.43
423.22
660.35
24


 


969
QGMPGSIR
11.4
423.22
717.37
24


 


970
QGMSGSIR
9.44
418.21
519.29
23


 


971
QGMSGSIR
9.45
418.21
650.33
23


 


972
QGMSGSIR
9.44
418.21
707.35
23


 


973
QGQTQQSYGNDLAR
11.16
783.37
895.43
39


 


974
QGQTQQSYGNDLAR
11.17
783.37
1023.49
39


 


975
QGQTQQSYGNDLAR
11.16
783.37
1151.54
39


 


976
QIDYGNADPSTIK
13.41
711.35
845.44
36


 


977
QIDYGNADPSTIK
13.42
711.35
902.46
36


 


978
QIDYGNADPSTIK
13.42
711.35
1065.52
36


 


979
QIDYGNVDPSTIK
15.08
725.36
873.47
37


 


980
QIDYGNVDPSTIK
15.07
725.36
930.49
37


 


981
QIDYGNVDPSTIK
15.07
725.36
1093.55
37


 


982
QIGQAR
2.3
336.69
431.24
20


 


983
QIGQAR
2.33
336.69
498.27
20


 


984
QIGQAR
2.32
336.69
544.32
20


 


985
QIMLIEQTPAFTLR
24.42
830.96
933.52
42


 


986
QIMLIEQTPAFTLR
24.42
830.96
1062.56
42


 


987
QIMLIEQTPAFTLR
24.42
830.96
1175.64
42


 


988
QLGSAIDQFWLR
22.67
717.38
864.44
37


 


989
QLGSAIDQFWLR
22.68
717.38
977.52
37


 


990
QLGSAIDQFWLR
22.67
717.38
1192.61
37


 


991
QLPVK
9.57
292.69
343.23
18


 


992
QLPVK
9.58
292.69
438.27
18


 


993
QLPVK
9.57
292.69
456.32
18


 


994
QLSLDVLDK
18.63
515.79
589.32
28


 


995
QLSLDVLDK
18.62
515.79
789.44
28


 


996
QLSLDVLDK
18.63
515.79
902.52
28


 


997
QLVYAR
11.04
375.22
508.29
22


 


998
QLVYAR
11.04
375.22
575.32
22


 


999
QLVYAR
11.04
375.22
621.37
22


 


1000
QMMLTEASTDYIIR
19.82
836.41
867.46
42


 


1001
QMMLTEASTDYIIR
19.82
836.41
1067.54
42


 


1002
QMMLTEASTDYIIR
19.82
836.41
1168.58
42


 


1003
QMSIVEATPDYVLHGK
18.77
894.45
1029.54
44


 


1004
QMSIVEATPDYVLHGK
18.77
894.45
1100.57
44


 


1005
QMSIVEATPDYVLHGK
18.77
894.45
1229.62
44


 


1006
QTLVFAR
14.65
417.75
492.29
23


 


1007
QTLVFAR
14.65
417.75
605.38
23


 


1008
QTLVFAR
14.65
417.75
706.42
23


 


1009
QVVFAR
12.06
360.21
492.29
21


 


1010
QVVFAR
12.04
360.21
545.31
21


 


1011
QVVFAR
12.06
360.21
591.36
21


 


1012
SADEVLPYGGKPQR
12.96
506.26
642.37
29


 


1013
SADEVLPYGGKPQR
12.96
506.26
805.43
29


 


1014
SADEVLPYGGKPQR
12.96
506.26
902.48
29


 


1015
SC[CAM]ATNDLAR
9.37
504.23
689.36
27


 


1016
SC[CAM]ATNDLAR
9.37
504.23
760.39
27


 


1017
SC[CAM]ATNDLAR
9.37
504.23
920.43
27


 


1018
SC[CAM]ATNNLAR
8.66
503.74
688.37
27


 


1019
SC[CAM]ATNNLAR
8.66
503.74
759.41
27


 


1020
SC[CAM]ATNNLAR
8.67
503.74
919.44
27


 


1021
SDIPGGSK
7.63
380.7
558.32
22


 


1022
SDIPGGSK
7.63
380.7
614.28
22


 


1023
SDIPGGSK
7.63
380.7
673.35
22


 


1024
SDWGK
5.75
296.64
390.21
18


 


1025
SDWGK
5.75
296.64
446.17
18


 


1026
SDWGK
5.75
296.64
505.24
18


 


1027
SEDNFHISSQQHEK
10.36
422.19
541.27
24


 


1028
SEDNFHISSQQHEK
10.36
422.19
730.28
24


 


1029
SEDNFHISSQQHEK
10.36
422.19
756.36
24


 


1030
SEMPASIR
12.02
445.72
674.37
25


 


1031
SEMPASIR
12.02
445.72
716.33
25


 


1032
SEMPASIR
12.02
445.72
803.41
25


 


1033
SEMPASTR
8.2
439.71
662.33
24


 


1034
SEMPASTR
8.19
439.71
704.29
24


 


1035
SEMPASTR
8.19
439.71
791.37
24


 


1036
SFAAHNQDQDLR
10.35
467.89
531.29
27


 


1037
SFAAHNQDQDLR
10.35
467.89
871.37
27


 


1038
SFAAHNQDQDLR
10.35
467.89
888.42
27


 


1039
SFAGHNK
9.4
380.69
455.24
22


 


1040
SFAGHNK
9.4
380.69
526.27
22


 


1041
SFAGHNK
9.38
380.69
673.34
22


 


1042
SFAGHNQDQDLR
10.18
694.32
888.42
36


 


1043
SFAGHNQDQDLR
10.18
694.32
1025.48
36


 


1044
SFAGHNQDQDLR
10.18
694.32
1082.5
36


 


1045
SFAGHNQDQNLR
9.8
462.89
530.3
27


 


1046
SFAGHNQDQNLR
9.8
462.89
773.39
27


 


1047
SFAGHNQDQNLR
9.8
462.89
887.43
27


 


1048
SFLESWAK
18.27
484.25
491.26
26


 


1049
SFLESWAK
18.27
484.25
620.3
26


 


1050
SFLESWAK
18.27
484.25
733.39
26


 


1051
SFTAWEK
14.44
434.71
462.23
24


 


1052
SFTAWEK
14.44
434.71
533.27
24


 


1053
SFTAWEK
14.44
434.71
634.32
24


 


1054
SFTTWEK
14.1
449.72
462.23
25


 


1055
SFTTWEK
14.1
449.72
563.28
25


 


1056
SFTTWEK
14.1
449.72
664.33
25


 


1057
SGSGWLR
13.25
381.7
531.3
22


 


1058
SGSGWLR
13.25
381.7
618.34
22


 


1059
SGSGWLR
13.25
381.7
675.36
22


 


1060
SGWGMAVDPQVGWYVGFVEK
24.65
738.02
841.45
41


 


1061
SGWGMAVDPQVGWYVGFVEK
24.65
738.02
1029.45
41


 


1062
SGWGMAVDPQVGWYVGFVEK
24.68
1106.53
1128.51
54


 


1063
SGWGMDVSPQVGWLTGWVEK
26.32
1110.03
1144.51
54


 


1064
SGWGMDVSPQVGWLTGWVEK
26.32
1110.03
1174.63
54


 


1065
SGWGMDVSPQVGWLTGWVEK
26.32
1110.03
1201.53
54


 


1066
SGWGMDVTPQVGWLTGWVEK
26.61
745.03
832.46
41


 


1067
SGWGMDVTPQVGWLTGWVEK
26.61
745.03
1018.54
41


 


1068
SGWGMDVTPQVGWLTGWVEK
26.61
745.03
1075.56
41


 


1069
SIHPASTFK
10.74
494.27
650.35
27


 


1070
SIHPASTFK
10.73
494.27
787.41
27


 


1071
SIHPASTFK
10.73
494.27
900.49
27


 


1072
SISTK
10.41
268.16
335.19
17


 


1073
SISTK
10.42
268.16
389.2
17


 


1074
SISTK
10.42
268.16
448.28
17


 


1075
SLGLSNNLSR
14.23
530.79
690.35
28


 


1076
SLGLSNNLSR
14.23
530.79
803.44
28


 


1077
SLGLSNNLSR
14.23
530.79
860.46
28


 


1078
SLSMSGK
9.31
355.18
509.24
21


 


1079
SLSMSGK
9.32
355.18
563.25
21


 


1080
SLSMSGK
9.32
355.18
622.32
21


 


1081
SMLFIEEK
17.82
498.76
518.28
27


 


1082
SMLFIEEK
17.82
498.76
665.35
27


 


1083
SMLFIEEK
17.82
498.76
778.43
27


 


1084
SNGLTHSWLGSSLK
16.78
743.89
877.48
38


 


1085
SNGLTHSWLGSSLK
16.78
743.89
1014.54
38


 


1086
SNGLTHSWLGSSLK
16.78
743.89
1115.58
38


 


1087
SPTWELKPEYNPSPR
16.02
600.97
733.36
34


 


1088
SPTWELKPEYNPSPR
16.02
600.97
808.91
34


 


1089
SPTWELKPEYNPSPR
16.02
600.97
959.46
34


 


1090
SQDIVR
8.4
359.2
502.3
21


 


1091
SQDIVR
8.38
359.2
543.28
21


 


1092
SQDIVR
8.4
359.2
630.36
21


 


1093
SQQKPTDPTIWLK
16.6
514.62
660.41
30


 


1094
SQQKPTDPTIWLK
16.6
514.62
757.46
30


 


1095
SQQKPTDPTIWLK
16.6
514.62
785.38
30


 


1096
SQVGWLTGWVEQPDGK
22.27
893.94
1015.5
44


 


1097
SQVGWLTGWVEQPDGK
22.28
893.94
1116.53
44


 


1098
SQVGWLTGWVEQPDGK
22.28
893.94
1229.62
44


 


1099
SSSNSC[CAM]TTNNAAR
16.84
685.29
907.41
35


 


1100
SSSNSC[CAM]TTNNAAR
16.85
685.29
994.44
35


 


1101
SSSNSC[CAM]TTNNAAR
16.84
685.29
1108.48
35


 


1102
SVYGELR
12.65
412.22
417.25
23


 


1103
SVYGELR
12.65
412.22
474.27
23


 


1104
SVYGELR
12.65
412.22
637.33
23


 


1105
SWILR
16.33
337.7
401.29
20


 


1106
SWILR
16.32
337.7
500.29
20


 


1107
SWILR
16.33
337.7
587.37
20


 


1108
SYLEK
9.09
320.17
389.24
19


 


1109
SYLEK
9.09
320.17
493.23
19


 


1110
SYLEK
9.1
320.17
552.3
19


 


1111
TAYIPASTFK
15.43
549.8
650.35
29


 


1112
TAYIPASTFK
15.43
549.8
763.43
29


 


1113
TAYIPASTFK
15.43
549.8
926.5
29


 


1114
TDDLFK
13.48
369.69
407.27
21


 


1115
TDDLFK
13.48
369.69
522.29
21


 


1116
TDDLFK
13.48
369.69
637.32
21


 


1117
TDINEIFK
17.44
490.26
650.35
27


 


1118
TDINEIFK
17.44
490.26
763.43
27


 


1119
TDINEIFK
17.44
490.26
878.46
27


 


1120
TFIHNDPR
18.92
500.25
751.38
27


 


1121
TFIHNDPR
18.92
500.25
825.39
27


 


1122
TFIHNDPR
18.92
500.25
898.45
27


 


1123
TGAGFTANR
9.64
447.72
461.25
25


 


1124
TGAGFTANR
9.64
447.72
665.34
25


 


1125
TGAGFTANR
9.64
447.72
793.4
25


 


1126
TGFNDGQK
7.5
433.7
561.26
24


 


1127
TGFNDGQK
7.5
433.7
708.33
24


 


1128
TGFNDGQK
7.5
433.7
765.35
24


 


1129
TGLADSK
9.7
346.18
533.29
20


 


1130
TGLADSK
9.67
346.18
545.26
20


 


1131
TGLADSK
9.7
346.18
590.31
20


 


1132
TGLDLMQK
15.32
453.24
634.32
25


 


1133
TGLDLMQK
15.32
453.24
747.41
25


 


1134
TGLDLMQK
15.32
453.24
804.43
25


 


1135
TGLELMQK
15.03
460.25
648.34
25


 


1136
TGLELMQK
15.03
460.25
761.42
25


 


1137
TGLELMQK
15.03
460.25
818.44
25


 


1138
TGMGYPK
10.28
377.18
464.25
22


 


1139
TGMGYPK
10.28
377.18
595.29
22


 


1140
TGMGYPK
10.28
377.18
652.31
22


 


1141
TGNGR
0.8
252.63
330.14
16


 


1142
TGNGR
0.8
252.63
346.18
16


 


1143
TGNGR
0.81
252.63
403.2
16


 


1144
TGTGSFIDAR
13.35
512.76
708.37
28


 


1145
TGTGSFIDAR
13.35
512.76
765.39
28


 


1146
TGTGSFIDAR
13.35
512.76
866.44
28


 


1147
TGTGSLSDAK
8.32
468.74
620.32
26


 


1148
TGTGSLSDAK
8.32
468.74
677.35
26


 


1149
TGTGSLSDAK
8.32
468.74
778.39
26


 


1150
TGVATEYQPEIGWWAGWVER
25.49
779.04
903.45
43


 


1151
TGVATEYQPEIGWWAGWVER
25.5
779.04
1146.55
43


 


1152
TGVATEYQPEIGWWAGWVER
25.52
1168.06
1189.57
56


 


1153
TGVSYPLLADGTR
17.4
675.36
842.47
35


 


1154
TGVSYPLLADGTR
17.41
675.36
1005.54
35


 


1155
TGVSYPLLADGTR
17.4
675.36
1092.57
35


 


1156
TGWAMDIK
16.71
461.23
577.3
25


 


1157
TGWAMDIK
16.71
461.23
763.38
25


 


1158
TGWAMDIK
16.72
461.23
820.4
25


 


1159
TGWATR
9.71
346.18
517.24
20


 


1160
TGWATR
9.69
346.18
533.28
20


 


1161
TGWATR
9.69
346.18
590.3
20


 


1162
TGWC[CAM]FDC[CAM]TPELGWWVGWVK
28.39
795.36
960.51
44


 


1163
TGWC[CAM]FDC[CAM]TPELGWWVGWVK
28.39
795.36
1017.53
44


 


1164
TGWC[CAM]FDC[CAM]TPELGWWVGWVK
28.38
795.36
1028.36
44


 


1165
TGWEGR
9.1
353.17
531.22
21


 


1166
TGWEGR
9.09
353.17
547.26
21


 


1167
TGWEGR
9.09
353.17
604.28
21


 


1168
TGWFVDK
16.08
426.72
694.36
24


 


1169
TGWFVDK
16.1
426.72
706.32
24


 


1170
TGWFVDK
16.08
426.72
751.38
24


 


1171
TGYDTK
2.09
342.66
526.25
20


 


1172
TGYDTK
2.09
342.66
538.21
20


 


1173
TGYDTK
2.08
342.66
583.27
20


 


1174
TGYGVR
8.09
326.67
478.23
19


 


1175
TGYGVR
8.1
326.67
494.27
19


 


1176
TGYGVR
8.1
326.67
551.29
19


 


1177
TGYSAR
2.24
327.66
480.21
19


 


1178
TGYSAR
2.24
327.66
496.25
19


 


1179
TGYSAR
2.24
327.66
553.27
19


 


1180
TGYSTR
2.08
342.67
510.22
20


 


1181
TGYSTR
2.08
342.67
526.26
20


 


1182
TGYSTR
2.08
342.67
583.28
20


 


1183
THESSNWGK
5.36
523.24
678.32
28


 


1184
THESSNWGK
5.37
523.24
807.36
28


 


1185
THESSNWGK
5.37
523.24
944.42
28


 


1186
TIC[CAM]TAIADAGTGK
14.35
639.82
732.39
33


 


1187
TIC[CAM]TAIADAGTGK
14.35
639.82
904.47
33


 


1188
TIC[CAM]TAIADAGTGK
14.35
639.82
1064.5
33


 


1189
TIGGAPDAYWVDDSLQISAR
21.22
712.35
1004.5
40


 


1190
TIGGAPDAYWVDDSLQISAR
21.22
712.35
1103.57
40


 


1191
TIGGAPDAYWVDDSLQISAR
21.21
1068.02
1103.57
52


 


1192
TLPFSASSYETLR
18.73
736.37
855.42
37


 


1193
TLPFSASSYETLR
18.73
736.37
1013.49
37


 


1194
TLPFSASSYETLR
18.73
736.37
1160.56
37


 


1195
TLPFSPK
15
395.23
478.27
22


 


1196
TLPFSPK
15
395.23
575.32
22


 


1197
TLPFSPK
15
395.23
688.4
22


 


1198
TLPFSQEVQDEVQSILFIEEK
28.55
827.09
891.52
45


 


1199
TLPFSQEVQDEVQSILFIEEK
28.56
827.09
978.55
45


 


1200
TLPFSQEVQDEVQSILFIEEK
28.56
827.09
1106.61
45


 


1201
TLPFSQEVQDEVQSMLFIEEK
27.7
833.08
996.51
46


 


1202
TLPFSQEVQDEVQSMLFIEEK
27.69
833.08
1124.57
46


 


1203
TLPFSQEVQDEVQSMLFIEEK
27.7
833.08
1223.63
46


 


1204
TLQNGWFEGFIISK
24.12
820.43
940.51
41


 


1205
TLQNGWFEGFIISK
24.11
820.43
1126.59
41


 


1206
TLQNGWFEGFIISK
24.11
820.43
1183.61
41


 


1207
TMQEYLNK
12.6
513.75
666.35
28


 


1208
TMQEYLNK
12.6
513.75
794.4
28


 


1209
TMQEYLNK
12.6
513.75
925.44
28


 


1210
TQTYQAYDAAR
11.2
644.3
666.32
33


 


1211
TQTYQAYDAAR
11.2
644.3
957.44
33


 


1212
TQTYQAYDAAR
11.2
644.3
1058.49
33


 


1213
TTDPTIWEK
14.39
545.77
676.37
29


 


1214
TTDPTIWEK
14.39
545.77
773.42
29


 


1215
TTDPTIWEK
14.39
545.77
888.45
29


 


1216
TTTTEVFK
12.06
463.75
522.29
25


 


1217
TTTTEVFK
12.06
463.75
623.34
25


 


1218
TTTTEVFK
12.06
463.75
724.39
25


 


1219
TWASNDFSR
13.73
542.25
638.29
29


 


1220
TWASNDFSR
13.73
542.25
725.32
29


 


1221
TWASNDFSR
13.73
542.25
796.36
29


 


1222
TWDMVQR
14.28
468.22
648.31
26


 


1223
TWDMVQR
14.28
468.22
761.33
26


 


1224
TWDMVQR
14.28
468.22
834.39
26


 


1225
TYVVDPAR
12.15
460.75
557.3
25


 


1226
TYVVDPAR
12.14
460.75
656.37
25


 


1227
TYVVDPAR
12.15
460.75
819.44
25


 


1228
VAFSLNIEMK
20.65
576.31
747.41
30


 


1229
VAFSLNIEMK
20.65
576.31
834.44
30


 


1230
VAFSLNIEMK
20.65
576.31
981.51
30


 


1231
VANSLIGLSTGAVR
17.97
679.39
760.43
35


 


1232
VANSLIGLSTGAVR
17.97
679.39
873.52
35


 


1233
VANSLIGLSTGAVR
17.97
679.39
986.6
35


 


1234
VELGK
7.74
273.17
342.2
17


 


1235
VELGK
7.75
273.17
399.22
17


 


1236
VELGK
7.74
273.17
446.26
17


 


1237
VFLDSWAK
18.2
483.26
606.29
26


 


1238
VFLDSWAK
18.2
483.26
719.37
26


 


1239
VFLDSWAK
18.2
483.26
866.44
26


 


1240
VFLESWAK
18.11
490.27
620.3
27


 


1241
VFLESWAK
18.11
490.27
733.39
27


 


1242
VFLESWAK
18.11
490.27
880.46
27


 


1243
VFLSSWAQDMNLSSAIK
23.66
948.98
978.49
47


 


1244
VFLSSWAQDMNLSSAIK
23.66
948.98
1106.55
47


 


1245
VFLSSWAQDMNLSSAIK
23.66
948.98
1177.59
47


 


1246
VGFER
10.32
304.16
433.21
18


 


1247
VGFER
10.32
304.16
451.23
18


 


1248
VGFER
10.32
304.16
508.25
18


 


1249
VILVFDQVR
19.69
544.83
664.34
29


 


1250
VILVFDQVR
19.69
544.83
763.41
29


 


1251
VILVFDQVR
19.69
544.83
876.49
29


 


1252
VMAAMVR
12.3
389.21
476.26
22


 


1253
VMAAMVR
12.3
389.21
547.3
22


 


1254
VMAAMVR
12.3
389.21
678.34
22


 


1255
VPLAVMGYDAGILVDAHNPR
21.61
703.37
709.34
39


 


1256
VPLAVMGYDAGILVDAHNPR
21.61
703.37
808.41
39


 


1257
VPLAVMGYDAGILVDAHNPR
21.61
703.37
921.49
39


 


1258
VQDEVQSMLFIEEK
20.48
847.92
996.51
42


 


1259
VQDEVQSMLFIEEK
20.48
847.92
1124.57
42


 


1260
VQDEVQSMLFIEEK
20.47
847.92
1223.63
42


 


1261
VQDGVQSMLFIEEK
20.26
811.91
996.51
41


 


1262
VQDGVQSMLFIEEK
20.27
811.91
1124.57
41


 


1263
VQDGVQSMLFIEEK
20.25
811.91
1223.63
41


 


1264
VSC[CAM]LPC[CAM]YQVVSHK
14.32
526.26
569.34
30


 


1265
VSC[CAM]LPC[CAM]YQVVSHK
14.32
526.26
860.46
30


 


1266
VSC[CAM]LPC[CAM]YQVVSHK
14.31
526.26
1020.49
30


 


1267
VSC[CAM]VWC[CAM]YQALAR
18.41
756.86
881.43
38


 


1268
VSC[CAM]VWC[CAM]YQALAR
18.41
756.86
1067.51
38


 


1269
VSC[CAM]VWC[CAM]YQALAR
18.41
756.86
1166.58
38


 


1270
VSDVC[CAM]SEVTAEGWQEVR
17.33
650.97
774.39
37


 


1271
VSDVC[CAM]SEVTAEGWQEVR
17.34
975.95
1075.52
48


 


1272
VSDVC[CAM]SEVTAEGWQEVR
17.34
975.95
1174.59
48


 


1273
VSEVEGWQIHGK
13.92
456.9
582.34
27


 


1274
VSEVEGWQIHGK
13.92
456.9
768.42
27


 


1275
VSEVEGWQIHGK
13.92
456.9
825.44
27


 


1276
VSFSLNIEMK
20.65
584.31
834.44
31


 


1277
VSFSLNIEMK
20.64
584.31
981.51
31


 


1278
VSFSLNIEMK
20.65
584.31
1068.54
31


 


1279
VSPC[CAM]SSFK
11.04
456.22
468.25
25


 


1280
VSPC[CAM]SSFK
11.04
456.22
628.28
25


 


1281
VSPC[CAM]SSFK
11.04
456.22
725.33
25


 


1282
VSQVPAYK
10.68
446.25
478.27
25


 


1283
VSQVPAYK
10.68
446.25
577.33
25


 


1284
VSQVPAYK
10.68
446.25
705.39
25


 


1285
VVFAR
11.17
296.18
393.22
18


 


1286
VVFAR
11.17
296.18
417.25
18


 


1287
VVFAR
11.17
296.18
492.29
18


 


1288
WDGAK
4.9
288.64
302.11
18


 


1289
WDGAK
4.9
288.64
390.2
18


 


1290
WDGAK
4.9
288.64
430.17
18


 


1291
WDGHIYDFPDWNR
20.52
574.25
590.27
33


 


1292
WDGHIYDFPDWNR
20.52
574.25
687.32
33


 


1293
WDGHIYDFPDWNR
20.52
574.25
887.37
33


 


1294
WDGIK
12.03
309.67
359.13
19


 


1295
WDGIK
12.03
309.67
432.25
19


 


1296
WDGIK
12.03
309.67
472.22
19


 


1297
WDGKPR
6.36
379.7
457.29
22


 


1298
WDGKPR
6.35
379.7
572.32
22


 


1299
WDGKPR
6.36
379.7
584.28
22


 


1300
WDGQTR
7.41
381.68
461.25
22


 


1301
WDGQTR
7.41
381.68
576.27
22


 


1302
WDGQTR
7.41
381.68
588.24
22


 


1303
WDGVK
10.1
302.66
359.13
18


 


1304
WDGVK
10.1
302.66
418.23
18


 


1305
WDGVK
10.1
302.66
458.2
18


 


1306
WDGVNR
10.39
373.68
445.25
21


 


1307
WDGVNR
10.39
373.68
560.28
21


 


1308
WDGVNR
10.42
373.68
572.25
21


 


1309
YAQAK
12.58
290.66
363.17
18


 


1310
YAQAK
12.58
290.66
417.25
18


 


1311
YAQAK
12.58
290.66
434.2
18


 


1312
YFSDFNAK
14.21
496.23
681.32
27


 


1313
YFSDFNAK
14.21
496.23
828.39
27


 


1314
YFSDFNAK
14.21
496.23
828.39
27


 


1315
YGTHLDR
8.51
431.21
641.34
24


 


1316
YGTHLDR
8.52
431.21
687.31
24


 


1317
YGTHLDR
8.51
431.21
698.36
24


 


1318
YLDELVK
15.52
440.24
488.31
24


 


1319
YLDELVK
15.53
440.24
603.33
24


 


1320
YLDELVK
15.52
440.24
716.42
24


 


1321
YLMITEAGR
15.86
527.27
533.27
28


 


1322
YLMITEAGR
15.86
527.27
646.35
28


 


1323
YLMITEAGR
15.86
527.27
777.39
28


 


1324
YLNLFSYGNANIGGGIDK
22.16
639.32
773.42
36


 


1325
YLNLFSYGNANIGGGIDK
22.16
958.48
1015.52
47


 


1326
YLNLFSYGNANIGGGIDK
22.16
958.48
1178.58
47


 


1327
YPVVWYSQQVAHHLGAQR
18.11
535.53
544.32
30


 


1328
YPVVWYSQQVAHHLGAQR
18.11
535.53
681.38
30


 


1329
YPVVWYSQQVAHHLGAQR
18.11
535.53
889.48
30


 


1330
YSNVLAFK
16.44
471.26
478.3
26


 


1331
YSNVLAFK
16.44
471.26
691.41
26


 


1332
YSNVLAFK
16.44
471.26
778.45
26


 


1333
YSPASTFK
12.22
450.73
553.3
25


 


1334
YSPASTFK
12.22
450.73
650.35
25


 


1335
YSPASTFK
12.22
450.73
737.38
25


 


1336
YSVVPVYQQLAR
18.42
711.89
778.42
36


 


1337
YSVVPVYQQLAR
18.42
711.89
974.54
36


 


1338
YSVVPVYQQLAR
18.43
711.89
1073.61
36


 


1339
YSVVWYSQLTAK
19.75
722.88
810.44
37


 


1340
YSVVWYSQLTAK
19.76
722.88
996.51
37


 


1341
YSVVWYSQLTAK
19.76
722.88
1095.58
37


 


1342
YSVVWYSQQVAHHLGAQR
18.61
533.02
544.32
30


 


1343
YSVVWYSQQVAHHLGAQR
18.61
533.02
681.38
30


 


1344
YSVVWYSQQVAHHLGAQR
18.61
533.02
889.48
30


 


1345
YTPASTFK
11.95
305.49
553.3
19


 


1346
YTPASTFK
11.98
457.73
553.3
25


 


1347
YTPASTFK
11.98
457.73
650.35
25


 


1348
YTSAFGYGNADVSGEPGK
15.03
607.28
673.35
34


 


1349
YTSAFGYGNADVSGEPGK
15.02
607.28
788.38
34


 


1350
YTSAFGYGNADVSGEPGK
15.02
910.41
1030.48
45


 


1351
YVFVSALTGNLGSNLTSSIK
23.66
691.04
906.49
39


 


1352
YVFVSALTGNLGSNLTSSIK
23.66
1036.06
1165.63
51


 


1353
YVFVSALTGNLGSNLTSSIK
23.67
1036.06
1190.64
51


 


1354
YVFVSALTGSLGSNLTSSIK
24.04
682.04
906.49
38


 


1355
YVFVSALTGSLGSNLTSSIK
24.04
1022.55
1106.61
50


 


1356
YVFVSALTGSLGSNLTSSIK
24.04
1022.55
1163.63
50









The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the three transitions of the same peptide are greater than or equal to 2500, the detection of the peptide is considered to be positive and is labelled “1”. When at least one transition comprises an area less than 2500, the corresponding peptide is considered non-detected and is labelled “0”.
EXAMPLE 25
Identification of a Resistance to ACC Beta-Lactams
Samples Sam96 to Sam101 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 31.










TABLE 31







Names
Species









Sam96
K. oxytoca



Sam97
S. livingstone



Sam98
Salmonella spp



Sam99
S. enterica ssp enterica



Sam100
K. pneumoniae



Sam101
H. alvei










Samples Sam96 to Sam101 correspond to a species able to comprise an ACC resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 32 instead of the peptides from TABLE 3.















TABLE 32







Charge




Colli-





state of

Retention
(m/z)
(m/z)
sion


Transition

the

time
filtered
filtered
energy
Positivity


number
Peptide
precursor
Fragment ion
(minutes)
in Q1
in Q3
(eV)
threshold























1
ANIDESK
2
y4 monocharged
2.45
388.69
478.21
17.9
2500


 


2
ANIDESK
2
y5 monocharged
2.37
388.69
591.3
17.9
2500


 


3
ANIDESK
2
y6 monocharged
2.41
388.69
705.34
17.9
2500


 


4
AWKPADAAGTHR
3
y9 dicharged
10.61
427.56
448.22
20.3
2500


 


5
AWKPADAAGTHR
3
y4 monocharged
10.61
427.56
470.25
20.3
2500


 


6
AWKPADAAGTHR
3
y10 dicharged
10.61
427.56
512.27
20.3
2500


 


7
DEPVHVNMEILGNEAYGIK
3
y9 dicharged
20.81
710.02
482.76
29.1
2500


 


8
DEPVHVNMEILGNEAYGIK
3
y8 monocharged
20.81
710.02
851.43
29.1
2500


 


9
DEPVHVNMEILGNEAYGIK
3
y9 monocharged
20.81
710.02
964.51
29.1
2500


 


10
DTVDDLIQPLMQK
3
y5 monocharged
22.36
505.93
616.35
22.8
2500


 


11
DTVDDLIQPLMQK
2
y5 monocharged
22.36
758.39
616.35
39
2500


 


12
DTVDDLIQPLMQK
2
y10 monocharged
22.36
758.39
1200.63
39
2500


 


13
ILSSLEGNK
2
y6 monocharged
13.47
480.77
647.34
23.1
2500


 


14
ILSSLEGNK
2
y7 monocharged
13.47
480.77
734.37
23.1
2500


 


15
ILSSLEGNK
2
y8 monocharged
13.47
480.77
847.45
23.1
2500


 


16
LSLDQSVSHYVPELR
3
y12 dicharged
20.27
581.64
715.36
25.1
2500


 


17
LSLDQSVSHYVPELR
3
y13 dicharged
20.27
581.64
771.9
25.1
2500


 


18
LSLDQSVSHYVPELR
3
y14 dicharged
20.27
581.64
815.42
25.1
2500


 


19
MGIVMLANK
2
y5 monocharged
18.15
488.77
576.32
23.6
2500


 


20
MGIVMLANK
2
y6 monocharged
18.15
488.77
675.39
23.6
2500


 


21
MGIVMLANK
2
y8 monocharged
18.13
488.77
845.49
23.6
2500


 


22
MQQALTATHTGYFK
3
y9 dicharged
15.01
532.93
513.26
23.6
2500


 


23
MQQALTATHTGYFK
3
y11 dicharged
15.01
532.93
605.32
23.6
2500


 


24
MQQALTATHTGYFK
3
y12 dicharged
15.01
532.93
669.35
23.6
2500


 


25
NNIPGMSVAVTVNGK
2
y5 monocharged
17.45
750.9
518.29
38.5
2500


 


26
NNIPGMSVAVTVNGK
2
y12 dicharged
17.43
750.9
580.31
38.5
2500


 


27
NNIPGMSVAVTVNGK
2
y12 monocharged
17.43
750.9
1159.61
38.5
2500


 


28
NTTQLMAYLK
2
y5 monocharged
19.34
591.81
625.34
29.5
2500


 


29
NTTQLMAYLK
2
y6 monocharged
19.34
591.81
738.42
29.5
2500


 


30
NTTQLMAYLK
2
y8 monocharged
19.36
591.81
967.53
29.5
2500


 


31
NYIYNYGLAAK
2
y7 monocharged
16.98
645.33
736.4
32.5
2500


 


32
NYIYNYGLAAK
2
y8 monocharged
16.98
645.33
899.46
32.5
2500


 


33
NYIYNYGLAAK
2
y9 monocharged
16.98
645.33
1012.55
32.5
2500


 


34
NYSIDQR
2
y3 monocharged
10.93
448.22
418.2
21.3
2500


 


35
NYSIDQR
2
y4 monocharged
10.91
448.22
531.29
21.3
2500


 


36
NYSIDQR
2
y5 monocharged
10.91
448.22
618.32
21.3
2500


 


37
QPQQPVTENTLFEVGSLSK
3
y5 monocharged
20.77
701.36
491.28
28.8
2500


 


38
QPQQPVTENTLFEVGSLSK
3
y7 monocharged
20.77
701.36
719.39
28.8
2500


 


39
QPQQPVTENTLFEVGSLSK
3
y8 monocharged
20.79
701.36
866.46
28.8
2500


 


40
SLGVSYEDAIEK
2
y6 monocharged
16.42
655.83
704.35
33.1
2500


 


41
SLGVSYEDAIEK
2
y8 monocharged
16.42
655.83
954.44
33.1
2500


 


42
SLGVSYEDAIEK
2
y10 monocharged
16.42
655.83
1110.53
33.1
2500


 


43
SVATPIVPPLPPQENVWINK
3
y10 dicharged
22.31
733.74
612.82
29.8
2500


 


44
SVATPIVPPLPPQENVWINK
3
y13 dicharged
22.29
733.74
766.42
29.8
2500


 


45
SVATPIVPPLPPQENVWINK
3
y10 monocharged
22.35
733.74
1224.64
29.8
2500


 


46
TFAATLASYAQVSGK
3
y6 monocharged
19.93
505.6
589.33
22.8
2500


 


47
TFAATLASYAQVSGK
2
y8 monocharged
19.93
757.9
839.43
38.9
2500


 


48
TFAATLASYAQVSGK
2
y9 monocharged
19.93
757.9
910.46
38.9
2500


 


49
TGSTNGFGAYIAFVPAK
3
y3 monocharged
21.68
567.63
315.2
24.7
2500


 


50
TGSTNGFGAYIAFVPAK
3
y6 monocharged
21.68
567.63
632.38
24.7
2500


 


51
TGSTNGFGAYIAFVPAK
2
y3 monocharged
21.68
850.94
315.2
44.2
2500


 


52
TLLPQLGMHHSYLK
3
y11 dicharged
17.99
546.63
655.84
24
2500


 


53
TLLPQLGMHHSYLK
3
y12 dicharged
17.95
546.63
712.38
24
2500


 


54
TLLPQLGMHHSYLK
2
y11 dicharged
17.97
819.45
655.84
42.4
2500


 


55
TTSSDLLR
2
y4 monocharged
13
446.74
516.31
21.2
2500


 


56
TTSSDLLR
2
y5 monocharged
13
446.74
603.35
21.2
2500


 


57
TTSSDLLR
2
y6 monocharged
13
446.74
690.38
21.2
2500


 


58
VPADQMENYAWGYNK
3
y4 monocharged
17.53
595.94
481.24
25.6
2500


 


59
VPADQMENYAWGYNK
3
y5 monocharged
17.53
595.94
667.32
25.6
2500


 


60
VPADQMENYAWGYNK
3
y6 monocharged
17.53
595.94
738.36
25.6
2500


 


61
VYSNIGTGLLGMIAAK
3
y6 monocharged
24.59
536.63
590.33
23.7
2500


 


62
VYSNIGTGLLGMIAAK
3
y7 monocharged
24.59
536.63
703.42
23.7
2500


 


63
VYSNIGTGLLGMIAAK
2
y11 monocharged
24.59
804.45
1031.59
41.6
2500


 


64
YVQANMGQLK
2
y4 monocharged
13.88
576.3
445.28
28.6
2500


 


65
YVQANMGQLK
2
y7 monocharged
13.88
576.3
761.4
28.6
2500


 


66
YVQANMGQLK
2
y8 monocharged
13.88
576.3
889.46
28.6
2500









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
no



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00
msec



Scanning speed:
10
Da/s



Curtain gas:
50.00
psi



Cone voltage:
5500.00
V



Source temperature:
500.00°
C.



Nebulising gas:
50.00
psi



Heating gas:
50.00
psi



Collision gas which 
9.00 
psi



induces dissociation:












Dynamic filling:
activated











Declustering potential 
100.00
V



(DP):





Entry potential before 
6.00
V



Q0 (EP):





Collision cell exit 
15
V



potential (CXP):





Total cycle time:
1.32
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 32, the detection of the transition is considered to be positive and is labelled “1” in TABLE 33. When a transition has an area less than the positivity threshold described in TABLE 32, the transition is considered non-detected and is labelled “0” in TABLE 33.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.













TABLE 33





Transition 








number
Sam96
Sam97
Sam98
Sam99
Sam100
Sam101





















1
0
1
1
1
1
0


2
0
1
1
1
1
0


3
0
1
1
1
1
0


4
1
1
1
1
1
1


5
1
1
1
1
1
1


6
1
1
1
1
1
1


7
1
1
1
1
1
0


8
1
1
1
1
1
0


9
1
1
1
1
1
0


10
1
1
1
1
1
0


11
1
1
1
1
1
0


12
1
1
1
1
1
0


13
1
1
1
1
1
0


14
1
1
1
1
1
0


15
1
1
1
1
1
0


16
1
1
1
1
1
1


17
1
1
1
1
1
1


18
1
1
1
1
1
1


19
1
1
1
1
1
0


20
1
1
1
1
1
0


21
1
1
1
1
1
0


22
1
1
1
1
1
1


23
1
1
1
1
1
1


24
1
1
1
1
1
1


25
1
1
1
1
1
1


26
1
1
1
1
1
1


27
1
1
1
1
1
1


28
1
1
1
1
1
0


29
1
1
1
1
1
0


30
1
1
1
1
1
0


31
1
1
1
1
1
0


32
1
1
1
1
1
0


33
1
1
1
1
1
0


34
1
1
1
1
1
0


35
1
1
1
1
1
0


36
1
1
1
1
1
0


37
1
1
1
1
1
0


38
1
1
1
1
1
0


39
1
1
1
1
1
0


40
1
1
1
1
1
1


41
1
1
1
1
1
1


42
1
1
1
1
1
1


43
1
1
1
1
1
1


44
1
1
1
1
1
1


45
1
1
1
1
1
1


46
1
1
1
1
1
0


47
1
1
1
1
1
0


48
1
1
1
1
1
0


49
1
1
1
1
1
1


50
1
1
1
1
1
1


51
1
1
1
1
1
1


52
1
1
1
1
1
0


53
1
1
1
1
1
0


54
1
1
1
1
1
0


55
1
1
1
1
1
1


56
1
1
1
1
1
1


57
1
1
1
1
1
1


58
1
0
0
0
1
0


59
1
0
0
0
1
0


60
1
0
0
0
1
0


61
1
1
1
1
1
1


62
1
1
1
1
1
1


63
1
1
1
1
1
1


64
1
1
1
1
1
1


65
1
1
1
1
1
1


66
1
1
1
1
1
1









Samples Sam96 to Sam101 comprise at least one peptide which is characteristic of the ACC proteins. The bacteria present in samples Sam96 to Sam101 therefore express a beta-lactamase which confers on them a resistance to penicillins and to cephalosporins, with the exception of fourth-generation cephalosporins.
EXAMPLE 26
Identification of a Resistance to CMY Beta-Lactams
Samples Sam102 to Sam108 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 34.










TABLE 34







Names
Species









Sam102
P. mirabilis



Sam103
S. senftenberg



Sam104
P. mirabilis



Sam105
K. oxytoca



Sam106
E. coli



Sam107
S. enterica ssp enterica



Sam108
P. mirabilis










Samples Sam102 to Sam108 correspond to a species able to comprise a CMY resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 35 instead of the peptides from TABLE 3.













TABLE 35







Retention
(m/z)
(m/z)
Collision



Transition

time
filtered in
filtered in
energy
Positivity


number
Peptide
(minutes)
Q1
Q3
(eV)
threshold





















1
AALLHFYQNWQPQWTPGAK
22.2
752.72
372.22
30.4
2500


 


2
AALLHFYQNWQPQWTPGAK
22.1
752.72
442.74
30.4
2500


 


3
AALLHFYQNWQPQWTPGAK
22.2
752.72
884.46
30.4
2500


 


4
ADIANNHPVTQQTLFELGSVSK
19.9
790.41
427.27
31.6
2500


 


5
ADIANNHPVTQQTLFELGSVSK
19.9
790.41
719.39
31.6
2500


 


6
ADIANNHPVTQQTLFELGSVSK
19.9
790.41
866.46
31.6
2500


 


7
ADSIINGSDSK
11.3
553.77
493.23
27.3
2500


 


8
ADSIINGSDSK
11.3
553.77
607.27
27.3
2500


 


9
ADSIINGSDSK
11.3
553.77
720.35
27.3
2500


 


10
ANIGGVDDK
10
444.73
533.26
21.1
2500


 


11
ANIGGVDDK
10
444.73
590.28
21.1
2500


 


12
ANIGGVDDK
10.1
444.73
703.36
21.1
2500


 


13
ASWVHK
9.3
364.2
383.24
16.5
2500


 


14
ASWVHK
9.3
364.2
569.32
16.5
2500


 


15
ASWVHK
9.3
364.2
656.35
16.5
2500


 


16
DYAWGYR
15.6
465.71
395.2
22.3
2500


 


17
DYAWGYR
15.6
465.71
581.28
22.3
2500


 


18
DYAWGYR
15.6
465.71
652.32
22.3
2500


 


19
ESGSQVLFNK
14.5
554.79
408.22
27.4
2500


 


20
ESGSQVLFNK
14.5
554.79
521.31
27.4
2500


 


21
ESGSQVLFNK
14.5
554.79
620.38
27.4
2500


 


22
GAMQLDDK
11.4
439.21
490.25
20.8
2500


 


23
GAMQLDDK
11.4
439.21
618.31
20.8
2500


 


24
GAMQLDDK
11.4
439.21
749.35
20.8
2500


 


25
GIGIVMLANR
19.9
522.31
604.32
25.5
2500


 


26
GIGIVMLANR
19.9
522.31
703.39
25.5
2500


 


27
GIGIVMLANR
19.9
522.31
873.5
25.5
2500


 


28
IGDMYQGLGWEMLNWPLK
27.9
717.69
357.25
29.3
2500


 


29
IGDMYQGLGWEMLNWPLK
27.9
717.69
657.37
29.3
2500


 


30
IGDMYQGLGWEMLNWPLK
27.9
717.69
901.5
29.3
2500


 


31
IPGMAVAVLK
19.3
499.81
600.41
24.2
2500


 


32
IPGMAVAVLK
19.3
499.81
788.47
24.2
2500


 


33
IPGMAVAVLK
19.3
499.81
885.52
24.2
2500


 


34
LAHTWITVPQNEQK
16.5
832.94
743.37
43.2
2500


 


35
LAHTWITVPQNEQK
16.5
832.94
943.48
43.2
2500


 


36
LAHTWITVPQNEQK
16.5
832.94
1242.65
43.2
2500


 


37
LLHLATYTAGGLPLQIPDDVR
22.8
755.09
526.79
30.5
2500


 


38
LLHLATYTAGGLPLQIPDDVR
23
755.09
601.29
30.5
2500


 


39
LLHLATYTAGGLPLQIPDDVR
23
755.09
1052.57
30.5
2500


 


40
LSDPVTK
11.1
380.22
444.28
17.4
2500


 


41
LSDPVTK
11.1
380.22
559.31
17.4
2500


 


42
LSDPVTK
11.1
380.22
646.34
17.4
2500


 


43
NLGIVMLANK
19.6
536.81
576.32
26.3
2500


 


44
NLGIVMLANK
19.6
536.81
675.39
26.3
2500


 


45
NLGIVMLANK
19.6
536.81
845.49
26.3
2500


 


46
QAMASYAYGYSK
14.1
670.3
454.23
33.9
2500


 


47
QAMASYAYGYSK
14.2
670.3
617.29
33.9
2500


 


48
QAMASYAYGYSK
14.1
670.3
688.33
33.9
2500


 


49
QWAPVYSPGSHR
14.7
692.84
553.28
35.2
2500


 


50
QWAPVYSPGSHR
14.8
692.84
640.32
35.2
2500


 


51
QWAPVYSPGSHR
14.8
692.84
999.5
35.2
2500


 


52
QWQGIR
13.1
394.21
345.22
18.2
2500


 


53
QWQGIR
13.1
394.21
473.28
18.2
2500


 


54
QWQGIR
13.1
394.21
659.36
18.2
2500


 


55
SSVIDMAR
14.3
439.72
492.22
20.8
2500


 


56
SSVIDMAR
14.3
439.72
605.31
20.8
2500


 


57
SSVIDMAR
14.3
439.72
704.38
20.8
2500


 


58
SYPNPVR
11.6
416.72
371.24
19.5
2500


 


59
SYPNPVR
11.6
416.72
485.28
19.5
2500


 


60
SYPNPVR
11.6
416.72
582.34
19.5
2500


 


61
TEQQIADIVNR
15.8
643.84
616.34
32.4
2500


 


62
TEQQIADIVNR
15.8
643.84
687.38
32.4
2500


 


63
TEQQIADIVNR
15.8
643.84
800.46
32.4
2500


 


64
TFNGVLGGDAIAR
17.9
645.84
602.33
32.5
2500


 


65
TFNGVLGGDAIAR
17.9
645.84
659.35
32.5
2500


 


66
TFNGVLGGDAIAR
17.9
645.84
772.43
32.5
2500


 


67
TITPLMQEQAIPGMAVAVIYQGK
24.9
820.44
617.34
32.5
2500


 


68
TITPLMQEQAIPGMAVAVIYQGK
25
820.44
778.45
32.5
2500


 


69
TITPLMQEQAIPGMAVAVIYQGK
24.9
820.44
1233.67
32.5
2500


 


70
TLQQGIALAQSR
15.5
643.37
574.33
32.4
2500


 


71
TLQQGIALAQSR
15.5
643.37
645.37
32.4
2500


 


72
TLQQGIALAQSR
15.5
643.37
815.47
32.4
2500


 


73
TLTATLGAYAVVK
19.7
654.38
707.41
33
2500


 


74
TLTATLGAYAVVK
19.7
654.38
820.49
33
2500


 


75
TLTATLGAYAVVK
19.7
654.38
921.54
33
2500


 


76
VALAALPAVEVNPPAPAVK
21.1
609.7
644.87
26
2500


 


77
VALAALPAVEVNPPAPAVK
21
609.7
679.41
26
2500


 


78
VALAALPAVEVNPPAPAVK
21
609.7
793.46
26
2500


 


79
VEAAWR
12
366.2
432.24
16.6
2500


 


80
VEAAWR
12
366.2
503.27
16.6
2500


 


81
VEAAWR
12
366.2
632.32
16.6
2500


 


82
VLQPLK
13.1
349.23
357.25
15.6
2500


 


83
VLQPLK
13.1
349.23
485.31
15.6
2500


 


84
VLQPLK
13
349.23
598.39
15.6
2500


 


85
VNPGMLADEAYGIK
18.8
739.37
632.82
37.9
2500


 


86
VNPGMLADEAYGIK
18.9
739.37
795.39
37.9
2500


 


87
VNPGMLADEAYGIK
18.9
739.37
866.43
37.9
2500


 


88
WVQANMDASHVQEK
13.4
548.26
615.28
24.1
2500


 


89
WVQANMDASHVQEK
13.4
548.26
679.31
24.1
2500


 


90
WVQANMDASHVQEK
13.4
548.26
728.85
24.1
2500


 


91
YWPELTGK
17.8
497.26
305.18
24.1
2500


 


92
YWPELTGK
17.8
497.26
418.27
24.1
2500


 


93
YWPELTGK
17.8
497.26
644.36
24.1
2500









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
yes



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00
msec



Scanning speed:
10
Da/s



Curtain gas:
50.00
psi



Cone voltage:
5500.00
V



Source temperature:
500.00°
C.



Nebulising gas:
50.00
psi



Heating gas:
50.00
psi



Collision gas which 
9.00
psi










induces dissociation: 




Dynamic filling:
activated











Declustering potential 
100.00
V



(DP):





Entry potential before 
6.00
V



Q0 (EP):





Collision cell exit 
15
V



potential (CXP):





Total cycle time:
0.04
sec



Detection window:
120
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 35, the detection of the transition is considered to be positive and is labelled “1” in TABLE 36. When a transition has an area less than the positivity threshold described in TABLE 35, the transition is considered non-detected and is labelled “0” in TABLE 36.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.














TABLE 36





Tran-









sition









num-









ber
Sam102
Sam103
Sam104
Sam105
Sam106
Sam107
Sam108






















1
0
0
0
1
0
0
1


2
0
0
0
1
0
0
1


3
0
0
0
1
0
0
1


4
0
0
0
0
1
0
0


5
0
0
0
0
1
0
0


6
0
0
0
0
1
0
0


7
1
1
1
1
1
1
1


8
1
1
1
1
1
1
1


9
1
1
1
1
1
1
1


10
0
0
0
0
0
0
0


11
0
0
0
0
0
0
0


12
0
0
0
0
0
0
0


13
1
1
1
1
1
1
1


14
1
1
1
1
1
1
1


15
1
1
1
1
1
1
1


16
0
1
0
1
1
1
0


17
0
1
0
1
1
1
0


18
0
1
0
1
1
1
0


19
0
0
0
1
0
0
0


20
0
0
0
1
0
0
0


21
0
0
0
1
0
0
0


22
0
0
0
0
0
0
1


23
0
0
0
0
0
0
1


24
0
0
0
0
0
0
1


25
0
0
0
0
0
0
0


26
0
0
0
0
0
0
0


27
0
0
0
0
0
0
0


28
0
0
0
1
0
0
0


29
0
0
0
1
0
0
0


30
0
0
0
1
0
0
0


31
0
0
0
0
0
0
0


32
0
0
0
0
0
0
0


33
0
0
0
0
0
0
0


34
1
1
1
1
1
1
1


35
1
1
1
1
1
1
1


36
1
1
1
1
1
1
1


37
0
0
0
0
0
0
0


38
0
0
0
0
0
0
0


39
0
0
0
0
0
0
0


40
1
1
1
1
0
1
1


41
1
1
1
1
0
1
1


42
1
1
1
1
0
1
1


43
1
1
1
1
1
1
1


44
1
1
1
1
1
1
1


45
1
1
1
1
1
1
1


46
0
0
0
0
0
0
0


47
0
0
0
0
0
0
0


48
0
0
0
0
0
0
0


49
0
0
0
0
0
0
0


50
0
0
0
0
0
0
0


51
0
0
0
0
0
0
0


52
1
1
1
1
1
1
1


53
1
1
1
1
1
1
1


54
1
1
1
1
1
1
1


55
1
1
1
1
1
1
1


56
1
1
1
1
1
1
1


57
1
1
1
1
1
1
1


58
0
1
1
1
1
0
1


59
0
1
1
1
1
0
1


60
0
1
1
1
1
0
1


61
1
1
1
1
1
1
1


62
1
1
1
1
1
1
1


63
1
1
1
1
1
1
1


64
1
1
1
1
1
1
1


65
1
1
1
1
1
1
1


66
1
1
1
1
1
1
1


67
1
0
0
0
0
1
0


68
1
0
0
0
0
1
0


69
1
0
0
0
0
1
0


70
1
1
1
1
1
1
1


71
1
1
1
1
1
1
1


72
1
1
1
1
1
1
1


73
0
0
0
0
0
0
0


74
0
0
0
0
0
0
0


75
0
0
0
0
0
0
0


76
1
1
1
1
1
1
1


77
1
1
1
1
1
1
1


78
1
1
1
1
1
1
1


79
1
1
1
1
1
1
1


80
1
1
1
1
1
1
1


81
1
1
1
1
1
1
1


82
1
1
1
1
1
1
1


83
1
1
1
1
1
1
1


84
1
1
1
1
1
1
1


85
0
0
1
0
1
1
1


86
0
0
1
0
1
1
1


87
0
0
1
0
1
1
1


88
1
1
1
1
1
1
1


89
1
1
1
1
1
1
1


90
1
1
1
1
1
1
1


91
1
1
1
1
0
1
1


92
1
1
1
1
0
1
1


93
1
1
1
1
0
1
1









Samples Sam102 to Sam108 comprise at least one peptide which is characteristic of the CMY proteins. The bacteria present in samples Sam102 to Sam108 therefore express a beta-lactamase which confers on them a resistance to penicillins and to cephalosporins, with the exception of fourth-generation cephalosporins.
EXAMPLE 27
Identification of a Resistance to CTX-M Beta-Lactams
Samples Sam109 to Sam118 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 37.










TABLE 37







Names
Species









Sam109
E. aerogenes



Sam110
E. coli



Sam111
E. coli



Sam112
E. coli



Sam113
E. coli



Sam114
K. pneumoniae



Sam115
K. pneumoniae



Sam116
P. mirabilis



Sam117
Salmonella spp



Sam118
Salmonella spp










Samples Sam109 to Sam118 correspond to a species able to comprise a CTX-M resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 38 instead of the peptides from TABLE 3.
















TABLE 38







Charge
Charge



(m/z)




Tran-

state
state of

Retention
(m/z)
filtered
Collision


sition

of the
the
Fragment
time
filtered
in
energy
Positivity


number
Peptide
precursor
fragment
ion
(minutes)
in Q1
Q3
(eV)
threshold
























1
AGLPK
2
1
y4
8.4
243.16
414.27
9.6
3000


 


2
AGLPK
2
1
y3
8.4
243.16
357.25
9.6
3000


 


3
AGLPK
2
2
y3
8.4
243.16
179.13
9.6
3000


 


4
AGLPTSWTVGDK
2
1
y9
18
616.32
990.49
30.9
2000


 


5
AGLPTSWTVGDK
2
1
y7
18
616.32
792.39
30.9
2000


 


6
AGLPTSWTVGDK
2
2
y9
17.9
616.32
495.75
30.9
2000


 


7
AIGDETFR
2
1
y6
13.5
454.73
724.33
21.7
2000


 


8
AIGDETFR
2
1
y5
13.5
454.73
667.31
21.7
2000


 


9
AIGDETFR
2
1
y4
13.5
454.73
552.28
21.7
2000


 


10
ALAETQR
2
1
y5
7.5
394.72
604.31
18.2
2000


 


11
ALAETQR
2
1
y4
7.5
394.72
533.27
18.2
2000


 


12
ALAETQR
2
2
y6
7.5
394.72
359.2
18.2
2000


 


13
ALGDSQR
2
1
y5
3.5
373.69
562.26
17
2000


 


14
ALGDSQR
2
1
y3
3.6
373.69
390.21
17
2000


 


15
ALGDSQR
2
2
y6
3.5
373.69
338.18
17
2000


 


16
AMAQTLR
2
1
y5
10.7
395.72
588.35
18.3
2000


 


17
AMAQTLR
2
1
y4
10.7
395.72
517.31
18.3
2000


 


18
AMAQTLR
2
1
y3
10.7
395.72
389.25
18.3
2000


 


19
APLILVTYFTQPQPK
2
1
y10
24.6
858.49
1208.63
44.7
2000


 


20
APLILVTYFTQPQPK
3
1
y6
24.6
572.66
698.38
24.8
2000


 


21
APLILVTYFTQPQPK
3
1
y4
24.6
572.66
469.28
24.8
2000


 


22
APLVLVTYFTQPQQNAESR
3
1
y8
23.6
721.38
929.44
29.4
2000


 


23
APLVLVTYFTQPQQNAESR
3
1
y6
23.6
721.38
704.33
29.4
2000


 


24
APLVLVTYFTQPQQNAESR
3
2
y8
23.6
721.38
465.23
29.4
2000


 


25
AQLVTWLK
2
1
y6
20
479.79
759.48
23.1
2000


 


26
AQLVTWLK
2
1
y5
20
479.79
646.39
23.1
2000


 


27
AQLVTWLK
2
1
y4
20
479.79
547.32
23.1
2000


 


28
AQLVTWMK
2
1
y6
18.5
488.77
777.43
23.6
2000


 


29
AQLVTWMK
2
1
y5
18.6
488.77
664.35
23.6
2000


 


30
AQLVTWMK
2
1
y4
18.5
488.77
565.28
23.6
2000


 


31
DILAAAAK
2
1
y6
14.1
386.73
544.35
17.8
2000


 


32
DILAAAAK
2
1
y5
14.1
386.73
431.26
17.8
2000


 


33
DILAAAAK
2
1
y4
14.1
386.73
360.22
17.8
2000


 


34
DTTSPR
2
1
y5
1
338.67
561.3
15
2000


 


35
DTTSPR
2
1
y4
1
338.67
460.25
15
2000


 


36
DTTSPR
2
1
y3
1
338.67
359.2
15
2000


 


37
DTTTPLAMAQTLK
2
1
y9
19.4
695.87
972.56
35.4
2000


 


38
DTTTPLAMAQTLK
2
1
y7
19.4
695.87
762.42
35.4
2000


 


39
DTTTPLAMAQTLK
2
2
y9
19.4
695.87
486.78
35.4
2000


 


40
DTTTPR
2
1
y5
1
345.67
575.32
15.4
2000


 


41
DTTTPR
2
1
y4
1
345.67
474.27
15.4
2000


 


42
DTTTPR
2
1
y3
1
345.67
373.22
15.4
2000


 


43
DVLAAAAK
2
1
y6
12.2
379.72
544.35
17.4
2000


 


44
DVLAAAAK
2
1
y5
12.2
379.72
431.26
17.4
2000


 


45
DVLAAAAK
2
1
y4
12.2
379.72
360.22
17.4
2000


 


46
DVLASAAK
2
1
y6
11.4
387.72
560.34
17.8
2000


 


47
DVLASAAK
2
1
y5
11.4
387.72
447.26
17.8
2000


 


48
DVLASAAK
2
1
y4
11.4
387.72
376.22
17.8
2000


 


49
DVLASAAR
2
1
y6
11.9
401.73
588.35
18.6
2000


 


50
DVLASAAR
2
1
y5
11.9
401.73
475.26
18.6
2000


 


51
DVLASAAR
2
1
y4
11.9
401.73
404.23
18.6
2000


 


52
FAMCSTSK
2
1
y7
11.6
466.2
784.33
22.3
2000


 


53
FAMCSTSK
2
1
y6
11.6
466.2
713.3
22.3
2000


 


54
FAMCSTSK
2
1
y5
11.6
466.2
582.26
22.3
2000


 


55
FPMCSTSK
2
1
y7
12.3
479.21
810.35
23.1
2000


 


56
FPMCSTSK
2
1
y6
12.3
479.21
713.3
23.1
2000


 


57
FPMCSTSK
2
2
y7
12.3
479.21
405.68
23.1
2000


 


58
GNTTGAASIQAGLPASWVVGDK
3
1
y9
21.1
700.7
958.5
29.1
2000


 


59
GNTTGAASIQAGLPASWVVGDK
3
1
y7
21.1
700.7
790.41
29.1
2000


 


60
GNTTGAASIQAGLPASWVVGDK
3
2
y9
21.2
700.7
479.75
29.1
2000


 


61
GNTTGAASIQAGLPTSWVVGDK
3
1
y9
21.3
710.7
988.51
29.1
8500


 


62
GNTTGAASIQAGLPTSWVVGDK
3
2
y9
21.3
710.7
494.76
29.1
8500


 


63
GNTTGAASIQAGLPTSWVVGDK
3
1
y3
21.3
710.7
319.16
29.1
8500


 


64
GNTTGAASIR
2
1
y7
9.3
474.25
675.38
22.8
2000


 


65
GNTTGAASIR
2
1
y6
9.3
474.25
574.33
22.8
2000


 


66
GNTTGAASIR
2
1
y4
9.3
474.25
446.27
22.8
2000


 


67
GNTTGSASIR
2
1
y8
8
482.25
792.42
23.2
2000


 


68
GNTTGSASIR
2
1
y7
8
482.25
691.37
23.2
2000


 


69
GNTTGSASIR
2
1
y6
8
482.25
590.33
23.2
2000


 


70
HLLNQR
2
1
y5
8.1
390.73
643.39
18
2000


 


71
HLLNQR
2
1
y4
8.1
390.73
530.31
18
2000


 


72
HLLNQR
2
1
y3
8.1
390.73
417.22
18
2000


 


73
LAALEK
2
1
y5
11.3
322.7
531.31
14.1
2000


 


74
LAALEK
2
1
y4
11.3
322.7
460.28
14.1
2000


 


75
LAALEK
2
1
y3
11.3
322.7
389.24
14.1
2000


 


76
LAELER
2
1
y5
11.7
365.71
617.33
16.6
2000


 


77
LAELER
2
1
y4
11.7
365.71
546.29
16.6
2000


 


78
LAELER
2
1
y3
11.7
365.71
417.25
16.6
2000


 


79
LGVALIDTADNTQVLYR
3
1
y6
21.5
621.34
779.44
26.3
2000


 


80
LGVALIDTADNTQVLYR
3
1
y5
21.5
621.34
678.39
26.3
2000


 


81
LGVALIDTADNTQVLYR
3
1
y4
21.5
621.34
550.34
26.3
2000


 


82
LGVALIDTADNTQVLYR
3
1
y3
21.4
621.34
451.27
26.3
2000


 


83
LGVALINTADNSQILYR
3
1
y6
21.4
621.01
779.44
26.3
2000


 


84
LGVALINTADNSQILYR
3
1
y5
21.4
621.01
692.41
26.3
2000


 


85
LGVALINTADNSQILYR
3
1
y4
21.4
621.01
564.35
26.3
2000


 


86
LGVALINTADNSQILYR
3
1
y3
21.4
621.01
451.27
26.3
2000


 


87
LIAHLGGPDK
3
1
y6
13.2
340.87
586.32
17.6
2000


 


88
LIAHLGGPDK
3
2
y9
13.2
340.87
454.25
17.6
2000


 


89
LIAHLGGPDK
3
2
y8
13.2
340.87
397.71
17.6
2000


 


90
LIAHVGGPASVTAFAR
3
1
y5
17.7
522.96
565.31
23.3
2000


 


91
LIAHVGGPASVTAFAR
3
1
y4
17.7
522.96
464.26
23.3
2000


 


92
LIAHVGGPASVTAFAR
3
1
y3
17.7
522.96
393.22
23.3
2000


 


93
LIAQLGGPGGVTAFAR
2
1
y11
20.3
764.44
989.52
39.3
2000


 


94
LIAQLGGPGGVTAFAR
2
1
y9
20.3
764.44
875.47
39.3
2000


 


95
LIAQLGGPGGVTAFAR
3
1
y5
20.3
509.96
565.31
22.9
2000


 


96
NLTLGK
2
1
y5
12.3
323.2
531.35
14.2
2000


 


97
NLTLGK
2
1
y4
12.3
323.2
418.27
14.2
2000


 


98
NLTLGK
2
1
y3
12.3
323.2
317.22
14.2
2000


 


99
QLGDETFR
2
1
y6
13.6
483.24
724.33
23.3
2000


 


100
QLGDETFR
2
1
y4
13.6
483.24
552.28
23.3
2000


 


101
QLGDETFR
2
1
y3
13.6
483.24
423.24
23.3
2000


 


102
QLTLGHALGETQR
3
2
y11
15.6
475.26
591.82
21.8
2000


 


103
QLTLGHALGETQR
3
1
y5
15.6
475.26
590.29
21.8
2000


 


104
QLTLGHALGETQR
3
2
y10
15.6
475.26
541.29
21.8
2000


 


105
QSESDK
2
1
y5
0.8
347.16
565.25
15.5
2000


 


106
QSESDK
2
1
y4
0.8
347.16
478.21
15.5
2000


 


107
QSESDK
2
1
y3
0.8
347.16
349.17
15.5
2000


 


108
QSETQK
2
1
y5
0.8
360.68
592.29
16.3
2000


 


109
QSETQK
2
1
y4
0.8
360.68
505.26
16.3
2000


 


110
QSETQK
2
1
y3
0.8
360.68
376.22
16.3
2000


 


111
QSGGR
2
1
y4
0.7
252.63
376.19
10.1
2000


 


112
QSGGR
2
1
y3
0.7
252.63
289.16
10.1
2000


 


113
QSGGR
2
2
y4
0.7
252.63
188.6
10.1
2000


 


114
SDLVNYNPIAEK
2
1
y8
17.3
681.85
948.48
34.6
2000


 


115
SDLVNYNPIAEK
2
1
y6
17.4
681.85
671.37
34.6
2000


 


116
SDLVNYNPIAEK
2
1
y5
17.4
681.85
557.33
34.6
2000


 


117
SESEPNLLNQR
2
1
y7
14.6
643.82
854.48
32.4
2000


 


118
SESEPNLLNQR
2
2
y7
14.6
643.82
427.75
32.4
2000


 


119
SESEPNLLNQR
3
1
y3
14.6
429.55
417.22
20.4
2000


 


120
SLGDETFR
2
1
y6
13.9
462.73
724.33
22.1
2000


 


121
SLGDETFR
2
1
y5
13.8
462.73
667.31
22.1
2000


 


122
SLGDETFR
2
1
y4
13.9
462.73
552.28
22.1
2000


 


123
SSGGR
2
1
y4
0.7
232.12
376.19
9
2000


 


124
SSGGR
2
1
y3
0.7
232.12
289.16
9
2000


 


125
SSGGR
2
2
y4
0.7
232.12
188.6
9
2000


 


126
SWVVGDK
2
1
y5
13.9
395.71
517.3
18.3
2000


 


127
SWVVGDK
2
1
y4
13.9
395.71
418.23
18.3
2000


 


128
SWVVGDK
2
1
y3
13.9
395.71
319.16
18.3
2000


 


129
TEPTLNTAIPGDPR
2
2
y12
16.3
741.38
626.34
38
2000


 


130
TEPTLNTAIPGDPR
2
1
y5
16.3
741.38
541.27
38
2000


 


131
TEPTLNTAIPGDPR
3
1
y5
16.3
494.59
541.27
22.4
2000


 


132
TGSGDYGTTNDIAVIWPK
2
1
y8
20.9
947.96
941.55
49.8
2000


 


133
TGSGDYGTTNDIAVIWPK
3
2
y6
21
632.31
357.22
26.7
2000


 


134
TGSGDYGTTNDIAVIWPK
3
2
y5
20.9
632.31
321.7
26.7
2000


 


135
TGSGDYGTTNDIAVIWPQGR
3
1
y6
20.5
703.34
756.42
28.9
2000


 


136
TGSGDYGTTNDIAVIWPQGR
3
1
y5
20.5
703.34
643.33
28.9
2000


 


137
TGSGDYGTTNDIAVIWPQGR
3
1
y4
20.5
703.34
457.25
28.9
2000


 


138
TGSGGYGTTNDIAVIWPK
2
1
y3
20.9
918.96
430.25
48.1
2000


 


139
TGSGGYGTTNDIAVIWPK
3
1
y6
20.9
612.98
713.43
26.1
2000


 


140
TGSGGYGTTNDIAVIWPK
3
1
y5
20.9
612.98
642.4
26.1
2000


 


141
VMAAAAVLK
2
1
y8
15.7
437.27
774.45
20.7
2000


 


142
VMAAAAVLK
2
1
y7
15.7
437.27
643.41
20.7
2000


 


143
VMAAAAVLK
2
1
y6
15.7
437.27
572.38
20.7
2000


 


144
VMAVAAVLK
2
1
y7
18.2
451.28
671.45
21.5
2000


 


145
VMAVAAVLK
2
1
y6
18.2
451.28
600.41
21.5
2000


 


146
VMAVAAVLK
2
1
y5
18.2
451.28
501.34
21.5
2000


 


147
VTAFAR
2
1
y5
11
332.69
565.31
14.7
2000


 


148
VTAFAR
2
1
y4
11
332.69
464.26
14.7
2000


 


149
VTAFAR
2
1
y3
11
332.69
393.22
14.7
2000









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
yes



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00
msec



Scanning speed:
10
Da/s



Curtain gas:
50.00 
psi



Cone voltage:
5500.00
V



Source temperature:
500.00°
C.



Nebulising gas:
50.00
psi



Heating gas:
50.00
psi



Collision gas which 
9.00
psi










induces dissociation:




Dynamic filling:
activated











Declustering potential 
100.00
V



(DP):





Entry potential before 
6.00
V



Q0 (EP):





Collision cell exit 
15
V



potential (CXP):





Total cycle time:
0.04 
sec



Detection window:
120
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 38, the detection of the transition is considered to be positive and is labelled “1” in TABLE 39. When a transition has an area less than the positivity threshold described in TABLE 38, the transition is considered non-detected and is labelled “0” in TABLE 39.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.

















TABLE 39





Transition












number 
Sam109
Sam110
Sam111
Sam112
Sam113
Sam114
Sam115
Sam116
Sam117
Sam118

























1
0
0
0
0
0
0
0
0
1
0


2
1
1
0
0
1
0
0
0
1
1


3
1
1
0
0
1
0
0
0
1
1


4
0
0
0
0
0
0
0
1
0
0


5
0
0
0
0
0
0
0
0
0
0


6
0
0
0
0
0
0
0
1
0
0


7
0
1
0
0
1
0
0
0
0
0


8
0
0
0
0
0
0
0
0
0
0


9
0
0
0
0
0
0
0
0
0
0


10
0
0
0
0
0
0
0
0
0
0


11
0
0
0
0
0
0
0
0
0
0


12
0
0
0
0
0
0
0
0
0
0


13
0
0
0
0
0
0
0
0
0
0


14
0
0
0
0
0
0
0
0
0
0


15
0
0
0
0
0
0
0
0
0
0


16
1
1
1
1
1
0
1
1
0
1


17
1
1
1
1
1
0
1
1
0
1


18
1
1
1
1
1
0
1
1
0
1


19
0
0
0
0
0
0
0
0
0
0


20
0
0
0
0
0
0
0
0
0
0


21
0
0
0
0
0
0
0
0
0
0


22
0
0
0
0
0
0
0
0
0
0


23
0
0
0
0
0
0
0
0
0
0


24
0
0
0
0
0
0
0
0
0
0


25
1
1
0
0
1
0
1
0
1
0


26
1
1
1
0
1
1
1
1
1
0


27
1
1
0
0
1
0
1
0
1
0


28
0
0
0
0
0
0
0
0
0
0


29
0
0
0
0
0
0
0
0
0
0


30
1
1
0
0
1
0
1
0
0
0


31
0
1
1
0
1
0
0
0
1
1


32
0
0
0
0
0
0
0
0
0
0


33
0
0
0
0
0
0
0
0
0
0


34
0
0
0
0
0
0
0
0
0
0


35
0
0
0
0
0
0
0
0
0
0


36
0
0
0
0
0
0
0
0
0
0


37
0
0
0
0
0
0
0
1
1
0


38
0
0
0
0
0
0
0
1
1
0


39
0
0
0
0
0
0
0
0
1
0


40
0
0
0
0
1
0
0
0
0
0


41
0
0
0
0
1
0
1
0
0
1


42
0
0
0
0
0
0
0
0
0
1


43
1
0
0
0
0
0
0
0
1
0


44
1
0
0
0
0
0
0
0
1
0


45
1
0
0
0
0
0
0
0
1
0


46
1
0
0
0
0
0
0
0
0
1


47
1
0
0
0
0
0
0
0
0
1


48
0
0
0
0
1
0
0
0
0
1


49
0
1
0
0
1
0
1
0
0
0


50
0
1
0
0
1
0
1
0
0
0


51
0
1
0
0
1
0
1
0
0
0


52
1
0
1
1
0
1
0
1
1
1


53
1
0
1
1
0
1
0
1
1
1


54
1
0
1
1
1
1
1
1
1
1


55
0
0
0
0
1
0
0
0
0
0


56
0
0
0
0
1
0
0
0
0
0


57
0
0
0
0
1
0
0
0
0
0


58
0
0
0
0
0
0
0
0
0
1


59
0
0
0
0
0
0
0
0
0
0


60
0
0
0
0
0
0
0
0
0
1


61
1
0
0
0
0
0
0
0
0
0


62
1
0
0
0
0
0
0
0
0
0


63
1
0
0
0
0
0
0
0
0
0


64
0
1
0
0
1
1
1
0
0
0


65
0
1
0
0
1
1
1
0
0
0


66
0
1
0
0
1
1
1
0
0
0


67
0
0
0
0
0
0
0
0
1
0


68
0
0
0
0
0
0
0
0
1
0


69
0
0
0
0
0
0
0
0
1
0


70
0
0
0
0
0
0
0
0
0
0


71
0
0
0
0
0
1
0
0
1
0


72
0
0
0
0
0
0
0
0
1
0


73
1
1
0
0
1
1
0
0
0
1


74
1
1
0
1
1
1
1
0
0
0


75
1
1
0
0
1
1
1
0
0
1


76
0
0
1
1
0
0
0
1
0
1


77
0
0
1
1
0
0
0
1
0
1


78
0
0
1
1
0
0
0
1
0
1


79
0
0
0
0
0
0
0
0
0
0


80
0
0
0
0
0
0
0
0
0
0


81
0
0
0
0
0
0
0
0
0
0


82
0
0
0
0
0
0
0
0
0
0


83
0
0
0
0
0
0
0
0
0
0


84
0
0
0
0
0
0
0
0
0
0


85
0
0
0
0
0
0
0
0
0
0


86
0
0
0
0
0
0
0
0
0
0


87
1
0
0
0
0
1
0
0
1
0


88
1
0
0
0
0
1
0
0
1
0


89
1
0
0
0
0
1
1
0
1
0


90
0
0
0
0
0
1
0
0
0
0


91
0
0
0
0
0
1
1
0
0
0


92
0
0
0
0
0
1
1
0
0
0


93
0
0
0
0
0
0
0
0
0
0


94
0
0
0
0
0
0
0
1
0
0


95
0
0
0
0
0
0
0
0
0
0


96
0
0
0
0
0
0
0
0
0
0


97
0
0
0
0
0
0
0
0
0
0


98
0
0
0
0
0
0
0
0
0
0


99
0
0
0
0
0
0
0
0
0
0


100
0
0
0
0
0
0
0
0
1
0


101
0
0
0
0
0
0
0
0
0
0


102
0
1
0
0
1
0
1
0
0
0


103
0
1
0
0
1
1
1
1
0
1


104
0
1
0
0
1
1
1
0
0
0


105
0
0
0
0
0
0
0
0
0
0


106
0
0
0
0
0
0
0
0
0
0


107
0
0
0
0
0
0
0
0
0
0


108
0
0
0
0
0
0
0
0
0
0


109
0
0
0
0
0
0
0
0
0
0


110
0
0
0
0
0
0
0
0
0
0


111
0
0
0
0
0
0
0
0
0
0


112
0
0
0
0
0
0
0
0
0
0


113
0
0
0
0
0
0
0
0
0
0


114
0
0
1
1
0
0
0
1
1
1


115
0
1
1
1
0
0
0
1
1
1


116
0
0
1
1
0
0
0
1
1
1


117
0
0
0
0
0
0
0
0
0
1


118
0
0
0
0
0
0
0
0
0
1


119
0
0
0
1
0
0
0
0
0
1


120
0
0
0
0
0
0
0
0
0
0


121
0
0
0
0
0
0
0
0
0
0


122
0
0
0
0
0
0
0
0
0
0


123
0
0
0
0
0
0
0
0
0
0


124
0
0
0
0
0
0
0
0
0
0


125
0
0
0
0
0
0
0
0
0
0


126
0
0
0
0
0
0
0
0
0
0


127
0
0
0
0
0
0
0
0
0
0


128
0
0
0
0
0
0
0
0
0
0


129
1
1
0
1
1
1
1
1
1
1


130
1
1
0
1
1
1
1
1
1
1


131
1
1
0
1
1
1
1
1
1
1


132
0
0
0
0
0
0
0
0
0
0


133
0
0
0
0
0
0
0
0
0
0


134
0
0
0
0
0
0
0
0
0
0


135
1
1
0
0
1
0
1
0
0
0


136
1
1
1
0
1
0
1
0
0
0


137
0
1
0
0
1
0
1
0
0
0


138
0
0
0
1
0
0
0
0
0
1


139
1
0
0
1
0
0
0
0
0
1


140
1
0
0
0
0
0
0
0
0
1


141
1
1
0
1
1
1
1
1
1
1


142
1
1
0
1
1
1
1
1
1
1


143
1
1
0
1
1
1
1
1
1
1


144
0
0
1
0
0
0
0
0
0
0


145
0
0
1
0
0
0
0
0
0
0


146
0
0
1
0
0
0
0
0
0
0


147
0
0
0
0
0
0
0
0
0
0


148
0
0
0
0
0
0
0
0
0
0


149
0
0
0
0
0
0
0
0
0
0









Samples Sam109 to Sam118 comprise at least one peptide which is characteristic of the CTX-M proteins. The bacteria present in samples Sam109 to Sam118 therefore express a beta-lactamase which confers on them a resistance to penicillins, to cephalosporins and to monobactams.
EXAMPLE 28
Identification of a Resistance to DHA Beta-Lactams
Samples Sam119 to Sam124 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 40.










TABLE 40







Names
Species









Sam119
E. coli



Sam120
K. oxytoca



Sam121
K. pneumoniae



Sam122
K. pneumoniae



Sam123
K. pneumoniae



Sam124
K. pneumoniae










Samples Sam119 to Sam124 correspond to a species able to comprise a DHA resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 41 instead of the peptides from TABLE 3.















TABLE 41







Charge










state

Retention
(m/z)
(m/z)
Collision


Transition

of the

time
filtered
filtered
energy
Positivity


number
Peptide
precursor
Fragment ion
(minutes)
in Q1
in Q3
(eV)
threshold























1
AAQAILSALEMK
2
y8 monocharged
21.45
623.35
904.52
31.3
2500


 


2
AAQAILSALEMK
2
y7 monocharged
21.45
623.35
791.43
31.3
2500


 


3
AAQAILSALEMK
2
y6 monocharged
21.45
623.35
678.35
31.3
2500


 


4
ADLLNFYQQWQPSR
2
y3 monocharged
22.92
883.44
359.2
46.1
2500


 


5
ADLLNFYQQWQPSR
3
y5 monocharged
22.92
589.29
673.34
25.4
2500


 


6
ADLLNFYQQWQPSR
3
y3 monocharged
22.92
589.29
359.2
25.4
2500


 


7
AGNADLEMAMYLAQTR
3
y6 monocharged
21.53
585.61
751.41
25.2
2500


 


8
AGNADLEMAMYLAQTR
3
y5 monocharged
21.53
585.61
588.35
25.2
2500


 


9
AGNADLEMAMYLAQTR
3
y4 monocharged
21.53
585.61
475.26
25.2
2500


 


10
EMALNDPAAK
2
y8 monocharged
13.12
530.26
799.43
26
2500


 


11
EMALNDPAAK
2
y6 monocharged
13.12
530.26
615.31
26
2500


 


12
EMALNDPAAK
2
y4 monocharged
13.12
530.26
386.24
26
2500


 


13
GKPYYFNYGFADIQAK
3
y8 monocharged
19.85
627.98
849.45
26.5
2500


 


14
GKPYYFNYGFADIQAK
3
y6 monocharged
19.85
627.98
645.36
26.5
2500


 


15
GKPYYFNYGFADIQAK
3
y5 monocharged
19.85
627.98
574.32
26.5
2500


 


16
NYPNTER
2
y5 monocharged
7.63
447.21
616.31
21.2
2500


 


17
NYPNTER
2
y3 monocharged
7.63
447.21
405.21
21.2
2500


 


18
NYPNTER
2
y5 dicharged
7.63
447.21
308.66
21.2
2500


 


19
QPVTENTLFELGSVSK
2
y8 monocharged
20.9
874.96
866.46
45.6
2500


 


20
QPVTENTLFELGSVSK
3
y8 monocharged
20.9
583.64
866.46
25.2
2500


 


21
QPVTENTLFELGSVSK
3
y5 monocharged
20.9
583.64
477.27
25.2
2500


 


22
QVAIVILANK
2
y8 monocharged
18.75
534.84
841.55
26.2
2500


 


23
QVAIVILANK
2
y6 monocharged
18.75
534.84
657.43
26.2
2500


 


24
QVAIVILANK
2
y5 monocharged
18.75
534.84
558.36
26.2
2500


 


25
TFTGVLGAVSVAK
2
y11 monocharged
20.03
625.36
1001.6
31.4
2500


 


26
TFTGVLGAVSVAK
2
y8 monocharged
20.03
625.36
744.46
31.4
2500


 


27
TFTGVLGAVSVAK
2
y7 monocharged
20.03
625.36
631.38
31.4
2500


 


28
TGATTGFGAYVAFIPEK
2
y3 monocharged
22.12
865.44
373.21
45.1
2500


 


29
TGATTGFGAYVAFIPEK
3
y6 monocharged
22.12
577.3
704.4
25
2500


 


30
TGATTGFGAYVAFIPEK
3
y3 monocharged
22.12
577.3
373.21
25
2500


 


31
VSPGQLDAESYGVK
2
y8 monocharged
15.43
725.37
868.41
37.1
2500


 


32
VSPGQLDAESYGVK
2
y13 dicharged
15.43
725.37
675.83
37.1
2500


 


33
VSPGQLDAESYGVK
2
y12 dicharged
15.43
725.37
632.31
37.1
2500


 


34
WAEMNMEPSR
2
y8 monocharged
15.78
625.77
993.41
31.4
2500


 


35
WAEMNMEPSR
2
y6 monocharged
15.78
625.77
733.33
31.4
2500


 


36
WAEMNMEPSR
2
y3 monocharged
15.78
625.77
359.2
31.4
2500


 


37
YQPELALPQWK
2
y4 monocharged
20.97
686.87
558.3
34.9
2500


 


38
YQPELALPQWK
2
y9 dicharged
20.97
686.87
541.31
34.9
2500


 


39
YQPELALPQWK
3
y4 monocharged
20.97
458.25
558.3
21.3
2500









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
no



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00
msec



Scanning speed:
10
Da/s



Curtain gas:
50.00
psi



Cone voltage:
5500.00
V



Source temperature:
500.00°
C.



Nebulising gas:
50.00
psi



Heating gas:
50.00
psi



Collision gas which 
9.00
psi










induces dissociation:




Dynamic filling:
activated











Declustering potential 
100.00 
V



(DP):





Entry potential before 
6.00
V



Q0 (EP):





Collision cell exit 
15
V



potential (CXP):





Total cycle time:
1.17
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 41, the detection of the transition is considered to be positive and is labelled “1” in TABLE 42. When a transition has an area less than the positivity threshold described in TABLE 41, the transition is considered non-detected and is labelled “0” in TABLE 42.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.













TABLE 42





Transition








number
Sam119
Sam120
Sam121
Sam122
Sam123
Sam124





















1
1
0
1
1
0
0


2
0
0
0
0
0
0


3
0
0
0
0
0
0


4
0
0
1
0
1
0


5
0
1
1
0
0
0


6
0
1
1
0
0
0


7
0
0
0
1
0
0


8
0
0
0
1
0
0


9
0
0
0
1
0
0


10
1
1
1
1
1
1


11
1
1
1
1
1
1


12
1
1
1
0
1
1


13
1
1
1
0
1
0


14
1
1
1
0
1
0


15
1
0
1
0
0
0


16
0
0
1
1
0
1


17
0
0
1
1
0
1


18
0
0
1
1
1
1


19
1
1
1
1
1
1


20
1
0
1
1
1
1


21
1
1
1
1
1
1


22
0
1
1
1
1
1


23
0
0
1
1
1
1


24
1
1
1
1
1
1


25
1
1
1
1
1
1


26
1
1
1
1
1
1


27
1
1
1
1
1
1


28
0
0
1
1
0
0


29
0
0
1
1
1
0


30
0
0
1
1
0
0


31
1
1
1
1
1
1


32
0
1
1
1
1
1


33
0
1
1
1
1
1


34
1
1
1
1
1
1


35
0
1
1
1
1
1


36
1
0
1
1
1
1


37
1
0
1
1
0
1


38
1
1
1
1
1
1


39
1
1
1
1
1
1









Samples 119 to Sam124 comprise at least one peptide which is characteristic of the DHA proteins. The bacteria present in samples Sam119 to Sam124 therefore express a beta-lactamase which confers on them a resistance to penicillins and to cephalosporins, with the exception of fourth-generation cephalosporins.
EXAMPLE 29
Identification of a Resistance to FOX Beta-Lactams
Samples Sam125 to Sam130 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 43.










TABLE 43







Names
Species









Sam125
E. coli



Sam126
E. coli



Sam127
K. oxytoca



Sam128
K. oxytoca



Sam129
K. pneumoniae



Sam13
K. pneumoniae










Samples Sam125 to Sam130 correspond to a species able to comprise a FOX resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 44 instead of the peptides from TABLE 3.















TABLE 44







Charge










state

Retention
(m/z)
(m/z)
Collision


Transition

of the

time
filtered
filtered
energy
Positivity


number
Peptide
precursor
Fragment ion
(minutes)
in Q1
in Q3
(eV)
threshold























1
AHYFNYGVANR
3
y3 monocharged
14.08
437.88
360.2
20.7
2500


 


2
AHYFNYGVANR
3
y4 monocharged
14.08
437.88
459.27
20.7
2500


 


3
AHYFNYGVANR
3
y5 monocharged
14.08
437.88
516.29
20.7
2500


 


4
AMGEQR
2
y5 dicharged
1.08
346.16
310.65
15.5
2500


 


5
AMGEQR
2
y4 monocharged
1.08
346.16
489.24
15.5
2500


 


6
AMGEQR
2
y5 monocharged
1.08
346.16
620.28
15.5
2500


 


7
ESGQR
2
y3 dicharged
0.8
288.64
180.6
12.2
2500


 


8
ESGQR
2
y3 monocharged
0.76
288.64
360.2
12.2
2500


 


9
ESGQR
2
y4 monocharged
0.82
288.64
447.23
12.2
2500


 


10
FAVPK
3
y4 monocharged
12.95
187.79
414.27
12.9
2500


 


11
FAVPK
2
y3 monocharged
12.95
281.17
343.23
11.8
2500


 


12
FAVPK
2
y4 monocharged
12.93
281.17
414.27
11.8
2500


 


13
GGFELDDK
2
y6 dicharged
14.31
440.71
383.69
20.9
2500


 


14
GGFELDDK
2
y4 monocharged
14.34
440.71
490.25
20.9
2500


 


15
GGFELDDK
2
y5 monocharged
14.31
440.71
619.29
20.9
2500


 


16
GIAIVMLANR
2
y4 monocharged
20.15
529.31
473.28
25.9
2500


 


17
GIAIVMLANR
2
y5 monocharged
20.13
529.31
604.32
25.9
2500


 


18
GIAIVMLANR
2
y6 monocharged
20.13
529.31
703.39
25.9
2500


 


19
IPGMAVAVLK
2
y9 dicharged
19.17
499.81
443.27
24.2
2500


 


20
IPGMAVAVLK
2
y8 monocharged
19.17
499.81
788.47
24.2
2500


 


21
IPGMAVAVLK
2
y9 monocharged
19.15
499.81
885.52
24.2
2500


 


22
NYPIEAR
2
y3 monocharged
12.04
431.73
375.2
20.3
2500


 


23
NYPIEAR
2
y4 monocharged
12.04
431.73
488.28
20.3
2500


 


24
NYPIEAR
2
y5 monocharged
12.06
431.73
585.34
20.3
2500


 


25
SWSPVYPAGTHR
3
y9 dicharged
14.97
453.23
499.26
21.1
2500


 


26
SWSPVYPAGTHR
3
y10 dicharged
14.97
453.23
542.78
21.1
2500


 


27
SWSPVYPAGTHR
3
y6 monocharged
14.97
453.23
638.34
21.1
2500


 


28
TGSADLLK
2
y5 monocharged
12.97
402.73
559.35
18.7
2500


 


29
TGSADLLK
2
y6 monocharged
12.95
402.73
646.38
18.7
2500


 


30
TGSADLLK
2
y7 monocharged
12.97
402.73
703.4
18.7
2500


 


31
TGSTGGFGAYVAFVPAR
3
y5 monocharged
21.03
553.28
589.35
24.2
2500


 


32
TGSTGGFGAYVAFVPAR
3
y6 monocharged
21.03
553.28
660.38
24.2
2500


 


33
TGSTGGFGAYVAFVPAR
2
y3 monocharged
21.03
829.42
343.21
43
2500


 


34
TGSTGGFGAYVAFVPAR
2
y6 monocharged
21.03
829.42
660.38
43
2500


 


35
TLTATLGAYAAVK
2
y7 monocharged
18.68
640.37
679.38
32.2
2500


 


36
TLTATLGAYAAVK
2
y8 monocharged
18.68
640.37
792.46
32.2
2500


 


37
TLTATLGAYAAVK
2
y9 monocharged
18.66
640.37
893.51
32.2
2500


 


38
VSEQTLFEIGSVSK
2
y5 monocharged
20.34
762.4
477.27
39.2
2500


 


39
VSEQTLFEIGSVSK
2
y7 monocharged
20.34
762.4
719.39
39.2
2500


 


40
VSEQTLFEIGSVSK
2
y8 monocharged
20.34
762.4
866.46
39.2
2500


 


41
VSQHAPWLK
3
y6 dicharged
14.1
355.87
376.22
18.1
2500


 


42
VSQHAPWLK
3
y8 dicharged
14.1
355.87
483.76
18.1
2500


 


43
VSQHAPWLK
3
y4 monocharged
14.1
355.87
543.33
18.1
2500


 


44
VTPGVLAAEAYGIK
2
y12 dicharged
19.37
694.89
594.84
35.3
2500


 


45
VTPGVLAAEAYGIK
2
y7 monocharged
19.37
694.89
751.4
35.3
2500


 


46
VTPGVLAAEAYGIK
2
y8 monocharged
19.37
694.89
822.44
35.3
2500









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
no



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00
msec



Scanning speed:
10
Da/s



Curtain gas:
50.00 
psi



Cone voltage:
5500.00
V



Source temperature:
500.00° 
C.



Nebulising gas:
50.00
psi



Heating gas:
50.00
psi



Collision gas which 
9.00
psi



induces dissociation:












Dynamic filling:
activated











Declustering potential
100.00 
V



(DP):





Entry potential before 
6.00
V



Q0 (EP):





Collision cell exit 
15
V



potential (CXP):





Total cycle time:
1.38
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 44, the detection of the transition is considered to be positive and is labelled “1” in TABLE 45. When a transition has an area less than the positivity threshold described in TABLE 44, the transition is considered non-detected and is labelled “0” in TABLE 45.
For a given peptide, when at least 2 transitions are labelled “1”, the peptide is considered as being detected.













TABLE 45





transition








number
Sam125
Sam126
Sam127
Sam128
Sam129
Sam130





















1
0
0
1
1
0
0


2
1
0
1
1
0
0


3
1
1
1
1
0
1


4
1
1
0
1
1
1


5
1
1
0
1
1
1


6
1
1
1
1
1
1


7
0
0
0
0
0
0


8
0
0
1
0
0
0


9
0
0
0
0
0
0


10
0
0
0
0
0
0


11
0
0
0
0
0
0


12
0
0
0
0
0
0


13
1
1
1
1
1
1


14
1
0
0
1
0
1


15
1
0
0
1
0
1


16
1
0
1
1
1
1


17
1
1
1
1
1
1


18
1
1
1
1
1
1


19
1
1
1
1
1
1


20
1
1
1
1
1
1


21
1
1
1
1
1
1


22
1
1
1
1
1
1


23
1
1
1
1
1
1


24
1
1
1
1
1
1


25
1
1
1
1
1
1


26
1
1
1
1
1
1


27
1
1
1
1
1
1


28
1
1
1
1
1
1


29
1
1
1
1
1
1


30
1
1
1
1
1
1


31
1
0
1
1
1
1


32
0
1
1
1
1
1


33
0
1
1
0
1
1


34
0
1
1
1
1
1


35
0
0
0
0
0
1


36
1
1
1
0
1
1


37
1
0
1
0
1
1


38
1
1
1
1
1
1


39
1
1
1
1
1
1


40
1
1
1
1
1
1


41
1
1
1
1
1
1


42
1
1
0
0
1
1


43
1
1
1
1
1
1


44
0
0
0
0
0
0


45
0
0
0
0
0
0


46
0
0
0
0
0
0









Samples Sam125 to Sam130 comprise at least one peptide which is characteristic of the FOX proteins. The bacteria present in samples Sam125 to Sam130 therefore express a beta-lactamase which confers on them a resistance to penicillins and to cephalosporins, with the exception of fourth-generation cephalosporins.
EXAMPLE 30
Identification of a Resistance to SHV Beta-Lactams
Samples Sam131 to Sam144 are identified according to one of the methods described in examples 1, 3 or 4. The identification of the species is set out in TABLE 46.










TABLE 46







Names
Species









Sam131
E. aerogenes



Sam132
E. coli



Sam133
E. coli



Sam134
E. coli



Sam135
E. coli



Sam136
K. pneumoniae



Sam137
K. pneumoniae



Sam138
K. pneumoniae



Sam139
K. pneumoniae



Sam140
K. pneumoniae



Sam141
K. pneumoniae



Sam142
K. pneumoniae



Sam143
K. pneumoniae



Sam144
K. pneumoniae










Samples Sam131 to Sam144 correspond to a species able to comprise an SHV resistance mechanism. Each sample is treated according to example 5, then analysed according to example 6 by detecting the peptides from TABLE 47 instead of the peptides from TABLE 3.















TABLE 47







Charge




Colli-



Tran-

state

Retention
(m/z)
(m/z)
sion


sition

of the

time
filtered
filtered
energy
Positivity


number
Peptide
precursor
Fragment ion
(minutes)
in Q1
in Q3
(eV)
threshold























1
AGAGER
2
y3 monocharged
0.9
280.64
361.18
11.7
2000


 


2
AGAGER
2
y4 monocharged
0.9
280.64
432.22
11.7
2000


 


3
AGAGER
2
y5 monocharged
0.9
280.64
489.24
11.7
2000


 


4
ATTTPASMAATLR
3
y5 monocharged
16.2
431.23
531.33
20.5
2000


 


5
ATTTPASMAATLR
2
y9 dicharged
16.2
646.34
459.25
32.6
2000


 


6
ATTTPASMAATLR
2
y9 monocharged
16.2
646.34
917.49
32.6
2000


 


7
CIISLLATLPLAVHASPQPLEQIK
3
y18 dicharged
27.4
871.5
957.05
34.1
2000


 


8
CIISLLATLPLAVHASPQPLEQIK
3
y21 dicharged
27.4
871.5
1113.65
34.1
2000


 


9
CIISLLATLPLAVHASPQPLEQIK
3
y22 dicharged
27.3
871.5
1170.19
34.1
2000


 


10
DMPASMAER
2
y7 dicharged
12.4
504.22
381.18
24.5
2000


 


11
DMPASMAER
2
y5 monocharged
12.4
504.22
593.27
24.5
2000


 


12
DMPASMAER
2
y7 monocharged
12.4
504.22
761.36
24.5
2000


 


13
DSPASMAER
2
y7 dicharged
10.5
482.21
381.18
23.2
2000


 


14
DSPASMAER
2
y5 monocharged
10.5
482.21
593.27
23.2
2000


 


15
DSPASMAER
2
y6 monocharged
10.5
482.21
664.31
23.2
2000


 


16
DTLASMAER
2
y5 monocharged
14
497.24
593.27
24.1
2000


 


17
DTLASMAER
2
y6 monocharged
14
497.24
664.31
24.1
2000


 


18
DTLASMAER
2
y7 monocharged
14
497.24
777.39
24.1
2000


 


19
DTPASMAER
2
y7 dicharged
10.5
489.22
381.18
23.6
2000


 


20
DTPASMAER
2
y5 monocharged
10.5
489.22
593.27
23.6
2000


 


21
DTPASMAER
2
y7 monocharged
10.5
489.22
761.36
23.6
2000


 


22
DTPASMAK
2
y6 dicharged
9.1
410.7
302.66
19.1
2000


 


23
DTPASMAK
2
y5 monocharged
9.1
410.7
507.26
19.1
2000


 


24
DTPASMAK
2
y6 monocharged
9.1
410.7
604.31
19.1
2000


 


25
DTTTPASMAATLR
3
y5 monocharged
16.5
445.89
531.33
20.9
2000


 


26
DTTTPASMAATLR
2
y9 dicharged
16.5
668.33
459.25
33.8
2000


 


27
DTTTPASMAATLR
2
y9 monocharged
16.5
668.33
917.49
33.8
2000


 


28
DTTTPASMAGTLR
3
y4 monocharged
15.3
441.22
446.27
20.8
2000


 


29
DTTTPASMAGTLR
2
y9 dicharged
15.3
661.32
452.24
33.4
2000


 


30
DTTTPASMAGTLR
2
y9 monocharged
15.3
661.32
903.47
33.4
2000


 


31
DTTTPASMTATLR
2
y9 dicharged
15.9
683.34
474.25
34.7
2000


 


32
DTTTPASMTATLR
2
y7 monocharged
15.9
683.34
779.41
34.7
2000


 


33
DTTTPASMTATLR
2
y9 monocharged
15.9
683.34
947.5
34.7
2000


 


34
FPMISTFK
2
y7 dicharged
20.2
485.76
412.22
23.4
2000


 


35
FPMISTFK
2
y5 monocharged
20.2
485.76
595.35
23.4
2000


 


36
FPMISTFK
2
y6 monocharged
20.2
485.76
726.39
23.4
2000


 


37
FPMMSTFK
2
y7 dicharged
19.3
494.74
421.2
23.9
2000


 


38
FPMMSTFK
2
y5 monocharged
19.3
494.74
613.3
23.9
2000


 


39
FPMMSTFK
2
y6 monocharged
19.3
494.74
744.34
23.9
2000


 


40
GIVALLGGNIK
2
y5 monocharged
21.1
527.84
488.28
25.8
2000


 


41
GIVALLGGNIK
2
y6 monocharged
21.1
527.84
601.37
25.8
2000


 


42
GIVALLGGNIK
2
y8 monocharged
21.1
527.84
785.49
25.8
2000


 


43
GIVALLGPDNK
2
y5 monocharged
18.9
548.82
530.26
27
2000


 


44
GIVALLGPDNK
2
y6 monocharged
19
548.82
643.34
27
2000


 


45
GIVALLGPDNK
2
y8 monocharged
18.9
548.82
827.46
27
2000


 


46
GIVALLGPNHK
3
y9 dicharged
17.6
373.56
474.79
18.7
2000


 


47
GIVALLGPNHK
3
y5 monocharged
17.6
373.56
552.29
18.7
2000


 


48
GIVALLGPNHK
3
y6 monocharged
17.6
373.56
665.37
18.7
2000


 


49
GIVALLGPNNK
2
y5 monocharged
18.6
548.33
529.27
27
2000


 


50
GIVALLGPNNK
2
y6 monocharged
18.6
548.33
642.36
27
2000


 


51
GIVALLGPNNK
2
y7 monocharged
18.6
548.33
755.44
27
2000


 


52
GIVALLGPNNNAER
3
y8 dicharged
18.8
479.93
436.2
22
2000


 


53
GIVALLGPNNNAER
2
y7 monocharged
18.8
719.39
814.38
36.7
2000


 


54
GIVALLGPNNNAER
2
y8 monocharged
18.7
719.39
871.4
36.7
2000


 


55
GIVALR
2
y4 dicharged
14.1
314.71
229.66
13.7
2000


 


56
GIVALR
2
y3 monocharged
14.1
314.71
359.24
13.7
2000


 


57
GIVALR
2
y4 monocharged
14.1
314.71
458.31
13.7
2000


 


58
GPNNK
2
y4 dicharged
0.8
265.14
236.63
10.8
2000


 


59
GPNNK
2
y3 monocharged
0.8
265.14
375.2
10.8
2000


 


60
GPNNK
2
y4 monocharged
0.8
265.14
472.25
10.8
2000


 


61
GTTTPASMAATLR
2
y9 dicharged
16
639.33
459.25
32.2
2000


 


62
GTTTPASMAATLR
2
y7 monocharged
16
639.33
749.4
32.2
2000


 


63
GTTTPASMAATLR
2
y9 monocharged
16
639.33
917.49
32.2
2000


 


64
HLADGMTVGELCAAAITMSDNSAAK
3
y6 monocharged
21.3
845.39
605.29
33.3
2000


 


65
HLADGMTVGELCAAAITMSDNSAAK
3
y7 monocharged
21.3
845.39
692.32
33.3
2000


 


66
HLADGMTVGELCAAAITMSDNSAAK
3
y9 monocharged
21.3
845.39
924.41
33.3
2000


 


67
HLLQWMVDDR
3
y3 monocharged
19.6
438.22
405.17
20.7
2000


 


68
HLLQWMVDDR
3
y4 monocharged
19.6
438.22
504.24
20.7
2000


 


69
HLLQWMVDDR
3
y5 monocharged
19.6
438.22
635.28
20.7
2000


 


70
IHYLQQDLVDYSPVSEK
3
y6 monocharged
19
678.68
646.34
28.1
2000


 


71
IHYLQQDLVDYSPVSEK
3
y7 monocharged
19
678.68
809.4
28.1
2000


 


72
IHYLQQDLVDYSPVSEK
3
y8 monocharged
18.9
678.68
924.43
28.1
2000


 


73
IVVIYLR
2
y3 monocharged
19.3
438.29
451.27
20.7
2000


 


74
IVVIYLR
2
y4 monocharged
19.3
438.29
564.35
20.7
2000


 


75
IVVIYLR
2
y5 monocharged
19.3
438.29
663.42
20.7
2000


 


76
LCIISLLAALPLAVHASPQPLEQIK
3
y17 dicharged
30.7
899.19
906.52
35
2000


 


77
LCIISLLAALPLAVHASPQPLEQIK
3
y18 dicharged
30.7
899.19
942.04
35
2000


 


78
LCIISLLAALPLAVHASPQPLEQIK
3
y22 dicharged
30.7
899.19
1155.18
35
2000


 


79
LCIISLLATLPLAVHASPQPLDQIK
3
y19 dicharged
30.2
904.52
1006.58
35.1
2000


 


80
LCIISLLATLPLAVHASPQPLDQIK
3
y22 dicharged
30.2
904.52
1163.18
35.1
2000


 


81
LCIISLLATLPLAVHASPQPLDQIK
3
y23 dicharged
30.3
904.52
1219.72
35.1
2000


 


82
LCIISLLATLPLAVHASPQPLEQIK
3
y15 dicharged
30.2
909.19
814.46
35.3
2000


 


83
LCIISLLATLPLAVHASPQPLEQIK
3
y17 dicharged
30.2
909.19
921.53
35.3
2000


 


84
LCIISLLATLPLAVHASPQPLEQIK
3
y19 dicharged
30.2
909.19
1013.59
35.3
2000


 


85
LCIISLLATLPLAVHSSPQPLEQIK
3
y15 dicharged
29.3
914.53
822.46
35.4
2000


 


86
LCIISLLATLPLAVHSSPQPLEQIK
3
y18 dicharged
29.3
914.53
965.04
35.4
2000


 


87
LCIISLLATLPLAVHSSPQPLEQIK
3
y21 dicharged
29.3
914.53
1121.64
35.4
2000


 


88
LCIISLLATLPLAVHTSPQPLEQIK
3
y15 dicharged
29.4
919.2
829.47
35.6
2000


 


89
LCIISLLATLPLAVHTSPQPLEQIK
3
y21 dicharged
29.5
919.2
1128.65
35.6
2000


 


90
LCIISLLATLPLAVHTSPQPLEQIK
3
y23 dicharged
29.4
919.2
1241.74
35.6
2000


 


91
LCIISLLATLPLTVHASPQPLEQIK
3
y15 dicharged
29.8
919.2
829.47
35.6
2000


 


92
LCIISLLATLPLTVHASPQPLEQIK
3
y17 dicharged
29.8
919.2
936.53
35.6
2000


 


93
LCIISLLATLPLTVHASPQPLEQIK
3
y22 dicharged
29.8
919.2
1185.19
35.6
2000


 


94
LCIISLLATLPLVVHASPQPLEQIK
3
y19 dicharged
31.3
918.54
1027.6
35.6
2000


 


95
LCIISLLATLPLVVHASPQPLEQIK
3
y21 dicharged
31.3
918.54
1127.66
35.6
2000


 


96
LCIISLLATLPLVVHASPQPLEQIK
3
y23 dicharged
31.3
918.54
1240.75
35.6
2000


 


97
LCIISLLATLSLAVHASPQPLEQIK
3
y18 dicharged
31.2
905.85
952.04
35.2
2000


 


98
LCIISLLATLSLAVHASPQPLEQIK
3
y22 dicharged
31.3
905.85
1165.18
35.2
2000


 


99
LCIISLLATLSLAVHASPQPLEQIK
3
y23 dicharged
31.2
905.85
1221.72
35.2
2000


 


100
LCIISLLATMPLAVHASPQPLEQIK
3
y18 dicharged
28.9
915.18
966.03
35.5
2000


 


101
LCIISLLATMPLAVHASPQPLEQIK
3
y19 dicharged
28.9
915.18
1022.57
35.5
2000


 


102
LCIISLLATMPLAVHASPQPLEQIK
3
y23 dicharged
28.9
915.18
1235.71
35.5
2000


 


103
LCIISLLAVLPLAVHASPQPLEQIK
3
y17 dicharged
31
908.54
920.54
35.2
2000


 


104
LCIISLLAVLPLAVHASPQPLEQIK
3
y22 dicharged
31.1
908.54
1169.2
35.2
2000


 


105
LCIISLLAVLPLAVHASPQPLEQIK
3
y23 dicharged
31.1
908.54
1225.74
35.2
2000


 


106
LLISQR
2
y3 monocharged
13.4
365.24
390.21
16.6
2000


 


107
LLISQR
2
y4 monocharged
13.4
365.24
503.29
16.6
2000


 


108
LLISQR
2
y5 monocharged
13.4
365.24
616.38
16.6
2000


 


109
LLLATVGGPAGLTAFLR
3
y4 monocharged
26.9
557.34
506.31
24.4
2000


 


110
LLLATVGGPAGLTAFLR
3
y5 monocharged
26.9
557.34
607.36
24.4
2000


 


111
LLLATVGGPAGLTAFLR
2
y11 monocharged
26.9
835.5
1059.6
43.4
2000


 


112
LLNSQR
2
y3 monocharged
8.4
365.71
390.21
16.6
2000


 


113
LLNSQR
2
y4 monocharged
8.4
365.71
504.25
16.6
2000


 


114
LLNSQR
2
y5 monocharged
8.4
365.71
617.34
16.6
2000


 


115
LLTNQR
2
y3 monocharged
9.3
372.72
417.22
17
2000


 


116
LLTNQR
2
y4 monocharged
9.3
372.72
518.27
17
2000


 


117
LLTNQR
2
y5 monocharged
9.3
372.72
631.35
17
2000


 


118
LLTSQR
2
y3 monocharged
9.5
359.22
390.21
16.2
2000


 


119
LLTSQR
2
y4 monocharged
9.5
359.22
491.26
16.2
2000


 


120
LLTSQR
2
y5 monocharged
9.5
359.22
604.34
16.2
2000


 


121
LNIISLLATLPLAVHASPQPLEQIK
3
y17 dicharged
30.8
893.87
921.53
34.8
2000


 


122
LNIISLLATLPLAVHASPQPLEQIK
3
y18 dicharged
30.7
893.87
957.05
34.8
2000


 


123
LNIISLLATLPLAVHASPQPLEQIK
3
y21 dicharged
30.8
893.87
1113.65
34.8
2000


 


124
LSASSQR
2
y4 monocharged
1.2
374.7
477.24
17.1
2000


 


125
LSASSQR
2
y5 monocharged
1.2
374.7
548.28
17.1
2000


 


126
LSASSQR
2
y6 monocharged
1.2
374.7
635.31
17.1
2000


 


127
LSESQLSGR
2
y8 dicharged
11.6
488.76
432.22
23.6
2000


 


128
LSESQLSGR
2
y6 monocharged
11.6
488.76
647.35
23.6
2000


 


129
LSESQLSGR
2
y7 monocharged
11.6
488.76
776.39
23.6
2000


 


130
LSESQLSGSVGMIEMDLASGR
3
y3 monocharged
23.7
723.02
319.17
29.5
2000


 


131
LSESQLSGSVGMIEMDLASGR
3
y4 monocharged
23.7
723.02
390.21
29.5
2000


 


132
LSESQLSGSVGMIEMDLASGR
3
y6 monocharged
23.7
723.02
618.32
29.5
3000


 


133
MVVIYLR
2
y3 monocharged
19.5
447.27
451.27
21.2
3000


 


134
MVVIYLR
2
y4 monocharged
19.5
447.27
564.35
21.2
3000


 


135
MVVIYLR
2
y5 monocharged
19.5
447.27
663.42
21.2
2000


 


136
NEALPGDAR
2
y5 monocharged
10.9
471.74
515.26
22.6
2000


 


137
NEALPGDAR
2
y6 monocharged
10.9
471.74
628.34
22.6
2000


 


138
NEALPGDAR
2
y7 monocharged
10.9
471.74
699.38
22.6
2000


 


139
NQHIAGIGAALIEHWQR
3
y13 dicharged
20.1
638.68
711.39
26.9
2000


 


140
NQHIAGIGAALIEHWQR
3
y14 dicharged
20.1
638.68
767.93
26.9
2000


 


141
NQHIAGIGAALIEHWQR
3
y15 dicharged
20.1
638.68
836.46
26.9
2000


 


142
NQQIAGIGAALIEHWQR
3
y13 dicharged
22.3
635.67
711.39
26.8
2000


 


143
NQQIAGIGAALIEHWQR
3
y14 dicharged
22.3
635.67
767.93
26.8
2000


 


144
NQQIAGIGAALIEHWQR
3
y15 dicharged
22.3
635.67
831.96
26.8
2000


 


145
NQQIAGLGAALIEHWQR
3
y13 dicharged
22.7
635.67
711.39
26.8
2000


 


146
NQQIAGLGAALIEHWQR
3
y14 dicharged
22.7
635.67
767.93
26.8
2000


 


147
NQQIAGLGAALIEHWQR
3
y15 dicharged
22.6
635.67
831.96
26.8
2000


 


148
NTTTPASMAATLR
3
y4 monocharged
16
445.56
460.29
20.9
2000


 


149
NTTTPASMAATLR
3
y5 monocharged
16
445.56
531.33
20.9
2000


 


150
NTTTPASMAATLR
2
y9 monocharged
16
667.84
917.49
33.8
2000


 


151
NVLTSQR
2
y3 monocharged
10.2
409.23
390.21
19.1
2000


 


152
NVLTSQR
2
y4 monocharged
10.2
409.23
491.26
19.1
2000


 


153
NVLTSQR
2
y5 monocharged
10.2
409.23
604.34
19.1
2000


 


154
QIDDNVTR
2
y4 monocharged
10
480.74
489.28
23.1
2000


 


155
QIDDNVTR
2
y5 monocharged
10
480.74
604.31
23.1
2000


 


156
QIDDNVTR
2
y6 monocharged
10
480.74
719.33
23.1
2000


 


157
QIGDK
3
y4 monocharged
1.1
187.44
432.25
12.9
2000


 


158
QIGDK
2
y3 monocharged
1.1
280.66
319.16
11.7
2000


 


159
QIGDK
2
y4 monocharged
1.1
280.66
432.25
11.7
2000


 


160
QIGDNVTR
2
y3 monocharged
10.2
451.74
375.24
21.5
2000


 


161
QIGDNVTR
2
y4 monocharged
10.2
451.74
489.28
21.5
2000


 


162
QIGDNVTR
2
y6 monocharged
10.2
451.74
661.33
21.5
2000


 


163
QIGENVTR
2
y3 monocharged
10.3
458.75
375.24
21.9
2000


 


164
QIGENVTR
2
y4 monocharged
10.3
458.75
489.28
21.9
2000


 


165
QIGENVTR
2
y6 monocharged
10.3
458.75
675.34
21.9
2000


 


166
QLLQWMVDAR
2
y5 monocharged
22.1
630.33
591.29
31.7
2000


 


167
QLLQWMVDAR
2
y6 monocharged
22.1
630.33
777.37
31.7
2000


 


168
QLLQWMVDAR
2
y7 monocharged
22.1
630.33
905.43
31.7
2000


 


169
QLLQWMVDDGVAGPLIR
3
y4 monocharged
25.7
637.68
498.34
26.8
2000


 


170
QLLQWMVDDGVAGPLIR
3
y5 monocharged
25.8
637.68
555.36
26.8
2000


 


171
QLLQWMVDDGVAGPLIR
3
y6 monocharged
25.7
637.68
626.4
26.8
2000


 


172
QLLQWMVDDR
2
y4 monocharged
21.7
652.33
504.24
32.9
2000


 


173
QLLQWMVDDR
2
y5 monocharged
21.7
652.33
635.28
32.9
2000


 


174
QLLQWMVDDR
2
y6 monocharged
21.7
652.33
821.36
32.9
2000


 


175
QLLQWMVDGR
2
y4 monocharged
21.4
623.32
446.24
31.3
2000


 


176
QLLQWMVDGR
2
y5 monocharged
21.4
623.32
577.28
31.3
2000


 


177
QLLQWMVDGR
2
y6 monocharged
21.4
623.32
763.36
31.3
2000


 


178
QLLQWMVEDR
3
y4 monocharged
21.7
439.89
518.26
20.7
2000


 


179
QLLQWMVEDR
2
y5 monocharged
21.7
659.34
649.3
33.3
2000


 


180
QLLQWMVEDR
2
y6 monocharged
21.7
659.34
835.38
33.3
2000


 


181
QQDLVDYSPVSEK
3
y5 monocharged
16
503.25
559.31
22.7
2000


 


182
QQDLVDYSPVSEK
2
y5 monocharged
16
754.37
559.31
38.7
2000


 


183
QQDLVDYSPVSEK
2
y8 monocharged
16
754.37
924.43
38.7
2000


 


184
QQHLVDYSPVSEK
3
y6 dicharged
14.2
510.59
323.67
22.9
2000


 


185
QQHLVDYSPVSEK
3
y5 monocharged
14.2
510.59
559.31
22.9
2000


 


186
QQHLVDYSPVSEK
3
y6 monocharged
14.3
510.59
646.34
22.9
2000


 


187
QSESQLSGR
2
y3 monocharged
7.2
496.24
319.17
24
2000


 


188
QSESQLSGR
2
y8 dicharged
7.2
496.24
432.22
24
2000


 


189
QSESQLSGR
2
y4 monocharged
7.2
496.24
432.26
24
2000


 


190
QSESQLSGSVGMIEMDLASGR
3
y3 monocharged
22.3
728.01
319.17
29.7
2000


 


191
QSESQLSGSVGMIEMDLASGR
3
y6 monocharged
22.3
728.01
618.32
29.7
2000


 


192
QSESQLSGSVGMIEMDLASGR
3
y8 monocharged
22.3
728.01
878.4
29.7
2000


 


193
SQLQLLQWMVDDR
3
y4 monocharged
24.9
544.61
504.24
24
2000


 


194
SQLQLLQWMVDDR
3
y5 monocharged
24.9
544.61
635.28
24
2000


 


195
SQLQLLQWMVDDR
3
y6 monocharged
24.9
544.61
821.36
24
2000


 


196
SVLPAGWFIADK
2
y9 dicharged
23.1
652.36
502.76
32.9
2000


 


197
SVLPAGWFIADK
2
y10 dicharged
23.1
652.36
559.31
32.9
2000


 


198
SVLPAGWFIADK
2
y9 monocharged
23.1
652.36
1004.52
32.9
2000


 


199
SVLPAGWFIADR
2
y9 dicharged
23.4
666.36
516.77
33.7
2000


 


200
SVLPAGWFIADR
2
y10 dicharged
23.4
666.36
573.31
33.7
2000


 


201
SVLPAGWFIADR
2
y9 monocharged
23.4
666.36
1032.53
33.7
2000


 


202
SVLSAGWFIADK
2
y7 monocharged
22.3
647.35
836.43
32.6
2000


 


203
SVLSAGWFIADK
2
y8 monocharged
22.3
647.35
907.47
32.6
2000


 


204
SVLSAGWFIADK
2
y9 monocharged
22.3
647.35
994.5
32.6
2000


 


205
TGAAER
2
y3 monocharged
1
302.66
375.2
13
2000


 


206
TGAAER
2
y4 monocharged
1
302.66
446.24
13
2000


 


207
TGAAER
2
y5 monocharged
1
302.66
503.26
13
2000


 


208
TGAAK
2
y4 dicharged
0.8
224.13
173.61
8.5
2000


 


209
TGAAK
2
y3 monocharged
0.8
224.13
289.19
8.5
2000


 


210
TGAAK
2
y4 monocharged
0.8
224.13
346.21
8.5
2000


 


211
TGAGER
2
y3 monocharged
1
295.65
361.18
12.6
2000


 


212
TGAGER
2
y4 monocharged
1
295.65
432.22
12.6
2000


 


213
TGAGER
2
y5 monocharged
1
295.65
489.24
12.6
2000


 


214
TGAGK
3
y4 monocharged
0.7
145.09
332.19
11.6
2000


 


215
TGAGK
2
y3 monocharged
0.7
217.12
275.17
8.1
2000


 


216
TGAGK
2
y4 monocharged
0.7
217.12
332.19
8.1
2000


 


217
TGASER
2
y3 monocharged
1
310.65
391.19
13.4
2000


 


218
TGASER
2
y4 monocharged
1
310.65
462.23
13.4
2000


 


219
TGASER
2
y5 monocharged
1
310.65
519.25
13.4
2000


 


220
TGASK
2
y4 dicharged
0.8
232.13
181.61
9
2000


 


221
TGASK
2
y3 monocharged
0.8
232.13
305.18
9
2000


 


222
TGASK
2
y4 monocharged
0.8
232.13
362.2
9
2000


 


223
TGASR
3
y4 monocharged
0.8
164.42
390.21
12.2
2000


 


224
TGASR
2
y3 monocharged
0.8
246.13
333.19
9.8
2000


 


225
TGASR
2
y4 monocharged
0.8
246.13
390.21
9.8
2000


 


226
TLTAWCADER
2
y5 monocharged
15.5
611.78
650.26
30.6
5200


 


227
TLTAWCADER
2
y6 monocharged
15.5
611.78
836.34
30.6
5200


 


228
TLTAWCADER
2
y8 monocharged
15.5
611.78
1008.42
30.6
5200


 


229
TLTAWHADER
3
y6 dicharged
13.1
400.53
407.19
19.5
2000


 


230
TLTAWHADER
3
y8 dicharged
13.1
400.53
493.23
19.5
2000


 


231
TLTAWHADER
3
y5 monocharged
13.1
400.53
627.28
19.5
2000


 


232
TLTAWR
2
y3 monocharged
14.6
374.21
432.24
17.1
2000


 


233
TLTAWR
2
y4 monocharged
14.6
374.21
533.28
17.1
2000


 


234
TLTAWR
2
y5 monocharged
14.6
374.21
646.37
17.1
2000


 


235
TVGGPAGLTAFLR
2
y5 monocharged
22
630.36
607.36
31.7
2000


 


236
TVGGPAGLTAFLR
2
y7 monocharged
22
630.36
777.46
31.7
2000


 


237
TVGGPAGLTAFLR
2
y11 monocharged
22
630.36
1059.6
31.7
2000


 


238
TVVIYLR
2
y3 monocharged
17.5
432.27
451.27
20.4
2000


 


239
TVVIYLR
2
y4 monocharged
17.5
432.27
564.35
20.4
2000


 


240
TVVIYLR
2
y5 monocharged
17.4
432.27
663.42
20.4
2000


 


241
VAGPLIR
2
y4 monocharged
13.8
363.24
498.34
16.4
2000


 


242
VAGPLIR
2
y5 monocharged
13.8
363.24
555.36
16.4
2000


 


243
VAGPLIR
2
y6 monocharged
13.8
363.24
626.4
16.4
2000


 


244
VALCGAVLAR
2
y8 dicharged
16.4
515.3
430.25
25.1
2000


 


245
VALCGAVLAR
2
y6 monocharged
16.4
515.3
586.37
25.1
2000


 


246
VALCGAVLAR
2
y7 monocharged
16.4
515.3
746.4
25.1
2000


 


247
VDAGDEQLER
2
y5 monocharged
11
566.27
674.35
28
2000


 


248
VDAGDEQLER
2
y7 monocharged
11
566.27
846.4
28
2000


 


249
VDAGDEQLER
2
y8 monocharged
11
566.27
917.43
28
2000


 


250
VDAGDK
2
y3 monocharged
1
302.65
319.16
13
2000


 


251
VDAGDK
2
y4 monocharged
1
302.65
390.2
13
2000


 


252
VDAGDK
2
y5 monocharged
1
302.65
505.23
13
2000


 


253
VGMIEMDLASGR
2
y6 monocharged
19.3
639.81
618.32
32.2
2000


 


254
VGMIEMDLASGR
2
y7 monocharged
19.3
639.81
749.36
32.2
2000


 


255
VGMIEMDLASGR
2
y8 monocharged
19.3
639.81
878.4
32.2
2000


 


256
VGMIEMDLASR
2
y6 monocharged
19.2
611.3
692.34
30.6
2000


 


257
VGMIEMDLASR
2
y7 monocharged
19.2
611.3
821.38
30.6
2000


 


258
VGMIEMDLASR
2
y8 monocharged
19.2
611.3
934.47
30.6
2000


 


259
VGMIEMDLASSR
2
y6 monocharged
18.8
654.82
648.33
33.1
2000


 


260
VGMIEMDLASSR
2
y7 monocharged
18.8
654.82
779.37
33.1
2000


 


261
VGMIEMDLASSR
2
y8 monocharged
18.8
654.82
908.41
33.1
2000


 


262
VLLCGAVLAR
2
y6 monocharged
18.2
536.32
586.37
26.3
5400


 


263
VLLCGAVLAR
2
y7 monocharged
18.3
536.32
746.4
26.3
5400


 


264
VLLCGAVLAR
2
y8 monocharged
18.3
536.32
859.48
26.3
5400


 


265
VVLCGAMLAR
2
y6 monocharged
17.7
545.3
618.34
26.8
2000


 


266
VVLCGAMLAR
2
y7 monocharged
17.7
545.3
778.37
26.8
2000


 


267
VVLCGAMLAR
2
y8 monocharged
17.7
545.3
891.45
26.8
2000


 


268
VVLCGAVLAR
2
y6 monocharged
17.2
529.31
586.37
25.9
2000


 


269
VVLCGAVLAR
2
y7 monocharged
17.2
529.31
746.4
25.9
2000


 


270
VVLCGAVLAR
2
y8 monocharged
17.2
529.31
859.48
25.9
2000


 


271
VVLCGTVLAR
2
y6 monocharged
16.9
544.32
616.38
26.8
2000


 


272
VVLCGTVLAR
2
y7 monocharged
16.9
544.32
776.41
26.8
2000


 


273
VVLCGTVLAR
2
y8 monocharged
16.9
544.32
889.49
26.8
2000


 


274
WETDR
3
y4 monocharged
8.2
236.11
520.24
14.4
2000


 


275
WETDR
2
y3 monocharged
8.2
353.66
391.19
15.9
2000


 


276
WETDR
2
y4 monocharged
8.2
353.66
520.24
15.9
2000


 


277
WETELNEAFPGDAR
3
y5 monocharged
19.1
545.59
515.26
24
2000


 


278
WETELNEAFPGDAR
3
y6 monocharged
19.1
545.59
662.33
24
2000


 


279
WETELNEAFPGDAR
2
y5 monocharged
19.1
817.88
515.26
42.4
2000


 


280
WETELNEALPADAR
3
y5 monocharged
18.5
538.93
529.27
23.8
2000


 


281
WETELNEALPADAR
2
y5 monocharged
18.5
807.89
529.27
41.8
2000


 


282
WETELNEALPADAR
2
y7 monocharged
18.5
807.89
713.39
41.8
2000


 


283
WETELNEALPGDAR
3
y5 monocharged
18.2
534.26
515.26
23.6
2000


 


284
WETELNEALPGDAR
2
y5 monocharged
18.2
800.88
515.26
41.4
2000


 


285
WETELNEALPGDAR
2
y7 monocharged
18.2
800.88
699.38
41.4
2000


 


286
WETELNEALSGDAR
3
y5 monocharged
18.9
530.92
505.24
23.5
2000


 


287
WETELNEALSGDAR
3
y6 monocharged
18.9
530.92
618.32
23.5
2000


 


288
WETELNEALSGDAR
2
y5 monocharged
18.9
795.87
505.24
41.1
2000


 


289
WETELNEVLPGDAR
3
y5 monocharged
20.1
543.6
515.26
23.9
2000


 


290
WETELNEVLPGDAR
2
y5 monocharged
20.1
814.9
515.26
42.2
2000


 


291
WETELNEVLPGDAR
2
y6 monocharged
20.1
814.9
628.34
42.2
2000


 


292
WETER
3
y4 monocharged
9
240.78
534.25
14.5
2000


 


293
WETER
2
y3 monocharged
8.9
360.67
405.21
16.3
2000


 


294
WETER
2
y4 monocharged
8.9
360.67
534.25
16.3
2000









The other machine parameters used are as follows:
















Scan type:
MRM



MRM planned:
yes



Polarity:
Positive



Ionising source:
Turbo V TM  (Applied BioSystems)



Q1 setting:
Filtering with unit resolution



Q3 setting:
Filtering with unit resolution











Inter-scan pause:
5.00
msec



Scanning speed:
10
Da/s



Curtain gas:
50.00 
psi



Cone voltage:
5500.00
V



Source temperature:
500.00° 
C.



Nebulising gas:
50.00
psi



Heating gas:
50.00
psi



Collision gas which 
9.00
psi



induces dissociation:












Dynamic filling:
activated











Declustering potential 
100.00
V



(DP):





Entry potential before 
6.00
V



Q0 (EP):





Collision cell exit 
15
V



potential (CXP):





Total cycle time:
1
sec



Detection window:
120
sec










The areas obtained for each of the transitions and for each of the microorganisms studied were measured. When the areas of the transitions are greater than or equal to the positivity threshold described in TABLE 47, the detection of the transition is considered to be positive and is labelled “1” in TABLE 48. When a transition has an area less than the positivity threshold described in TABLE 47, the transition is considered non-detected and is labelled “0” in TABLE 48.
For a given peptide, when at least 3 transitions are labelled “1”, the peptide is considered as being detected.





















TABLE 48





transition
















number
Sam131
Sam132
Sam133
Sam134
Sam135
Sam136
Sam137
Sam138
Sam139
Sam140
Sam141
Sam142
Sam143
Sam144





























1
0
0
0
0
0
0
0
0
0
0
0
0
0
0


2
0
0
0
0
0
0
0
0
1
0
0
0
1
0


3
0
0
0
0
0
0
0
0
0
0
0
0
1
0


4
0
0
0
0
0
0
0
0
0
0
0
0
0
0


5
0
0
0
0
0
0
0
0
0
0
0
0
0
0


6
0
0
0
0
0
0
0
0
0
0
0
0
0
0


7
0
0
0
0
0
0
0
0
0
0
0
0
0
0


8
0
0
0
0
0
0
0
0
0
0
0
0
0
0


9
0
0
0
0
0
0
0
0
0
0
0
0
0
0


10
0
0
0
0
0
0
0
0
0
0
0
0
0
0


11
0
0
0
0
1
0
0
0
0
0
0
0
0
0


12
0
0
0
0
1
0
0
0
0
0
0
0
0
0


13
0
0
0
0
0
0
0
0
0
0
0
0
0
0


14
0
0
0
0
0
0
0
1
0
0
0
0
1
0


15
0
0
0
0
0
0
0
0
0
0
0
0
0
0


16
0
0
0
0
0
0
0
0
0
0
0
0
0
0


17
1
0
0
0
0
1
1
1
1
1
1
1
1
1


18
0
0
0
0
0
0
0
0
0
0
0
0
0
0


19
1
0
0
0
1
1
1
1
1
0
0
1
1
1


20
1
0
0
0
1
1
1
0
1
0
0
1
1
1


21
1
0
1
0
1
1
1
0
1
0
0
1
1
0


22
0
0
0
0
0
0
0
0
0
0
0
0
0
0


23
0
0
0
0
0
0
0
0
0
0
0
0
0
0


24
0
0
0
0
0
0
0
0
0
0
0
0
0
0


25
1
1
1
0
1
1
1
0
1
0
1
1
1
0


26
1
1
1
0
1
1
1
0
1
1
1
1
1
0


27
0
1
1
0
1
1
1
0
1
0
1
1
1
0


28
0
0
0
0
0
0
0
0
0
0
0
0
0
0


29
0
0
0
0
0
0
0
0
0
0
0
0
0
0


30
0
0
0
0
0
0
0
0
0
0
0
0
0
0


31
0
0
0
0
0
1
0
0
0
0
0
0
0
0


32
0
0
0
0
0
0
0
0
0
0
0
0
0
0


33
0
0
0
0
0
0
0
0
0
0
0
0
0
0


34
0
0
0
0
0
0
0
0
0
0
0
0
0
0


35
0
0
0
0
0
0
0
0
0
0
0
0
0
0


36
0
0
0
0
0
0
0
0
0
0
0
0
0
0


37
0
0
0
0
0
0
0
0
0
0
0
0
0
0


38
0
0
0
0
1
0
0
1
0
0
0
0
1
0


39
0
0
0
0
0
0
0
0
0
0
0
0
0
0


40
0
0
0
0
0
0
0
0
0
0
0
0
0
0


41
0
0
0
0
0
0
0
0
0
0
0
0
0
0


42
0
0
0
0
0
0
0
0
0
0
0
0
0
0


43
0
0
0
0
1
1
1
0
1
0
0
1
1
0


44
0
0
0
0
1
1
1
0
1
0
0
1
1
0


45
0
0
1
1
1
1
1
0
0
0
0
1
1
0


46
0
0
0
0
0
0
0
0
0
0
0
0
0
0


47
0
0
0
0
0
0
0
0
0
0
0
0
0
0


48
0
0
0
0
0
0
0
0
0
0
0
0
0
0


49
1
1
1
1
1
1
1
1
1
1
1
1
1
1


50
1
1
1
1
1
1
1
1
1
1
1
1
1
1


51
1
1
1
1
1
1
1
1
1
1
1
1
1
1


52
1
0
0
0
0
0
0
0
0
0
0
0
0
0


53
0
0
0
0
0
0
0
0
0
0
0
0
0
0


54
1
0
0
0
0
0
0
0
0
0
0
0
0
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0
0
0
0
0


237
0
0
0
0
0
0
0
0
0
0
0
0
0
0


238
0
0
0
0
0
0
0
0
0
0
0
0
0
0


239
0
0
0
0
0
0
0
0
0
0
0
0
0
0


240
0
0
0
0
0
0
0
0
0
0
0
0
0
0


241
1
1
1
1
1
1
1
1
1
1
1
1
1
1


242
1
1
1
1
1
1
1
0
1
0
1
1
1
1


243
1
1
1
1
1
1
1
0
1
0
1
1
1
1


244
0
0
0
0
0
0
0
0
1
0
0
0
0
0


245
0
0
0
0
1
0
0
0
0
0
0
0
0
0


246
0
0
0
0
0
0
0
0
0
0
0
0
0
0


247
1
0
1
0
1
1
1
0
1
0
1
1
1
0


248
1
1
1
1
1
1
1
1
1
1
1
1
1
1


249
1
1
1
1
1
1
1
0
1
1
1
1
1
1


250
0
0
0
0
0
0
0
0
0
0
0
0
0
0


251
0
1
1
1
0
0
0
0
0
0
0
0
0
0


252
0
0
0
0
0
0
0
0
0
0
0
0
0
0


253
0
0
0
0
1
0
1
0
1
0
0
1
1
0


254
0
0
0
0
1
0
1
0
1
0
0
1
1
0


255
0
0
0
0
1
0
1
0
1
0
0
1
1
0


256
0
0
0
0
0
0
0
0
0
0
0
0
0
0


257
0
0
0
0
0
0
0
0
0
0
0
0
0
0


258
0
0
0
0
0
0
0
0
0
0
0
0
0
0


259
0
0
0
0
0
0
0
0
0
0
0
0
0
0


260
0
0
0
0
0
0
0
0
0
0
0
0
0
0


261
0
0
0
0
0
0
0
0
0
0
0
0
0
0


262
0
0
0
0
0
0
0
0
0
0
0
1
1
0


263
0
0
0
0
0
0
0
0
0
0
1
0
1
0


264
0
0
0
0
0
0
0
0
0
0
0
1

0


265
0
0
0
0
0
0
0
0
0
0
0
0
0
0


266
0
0
0
0
0
0
0
0
0
0
0
0
0
0


267
0
0
0
0
0
1
0
0
0
0
0
0
0
0


268
0
0
0
0
0
0
0
0
0
0
0
0
0
0


269
0
0
0
0
0
0
0
0
0
0
0
0
0
0


270
0
0
0
0
0
0
0
0
0
0
0
0
0
0


271
0
0
0
0
0
0
0
0
0
0
0
0
0
0


272
0
0
0
0
0
0
0
0
0
1
0
0
0
0


273
0
0
0
0
0
0
0
0
0
1
0
0
0
0


274
0
0
0
0
0
0
0
0
0
0
0
0
0
0


275
0
0
0
0
0
0
0
0
0
0
0
0
0
0


276
0
0
0
0
0
0
0
0
0
0
0
0
0
0


277
0
0
0
0
0
0
0
0
0
0
0
0
0
0


278
0
0
0
0
0
0
0
0
0
0
0
0
0
0


279
0
0
0
0
0
0
0
0
0
0
0
0
0
0


280
0
0
0
0
1
0
0
0
0
0
0
0
0
0


281
0
0
0
0
0
0
0
0
0
0
0
0
0
0


282
0
0
0
0
1
0
0
0
0
0
0
0
0
0


283
0
0
0
0
1
1
1
0
0
0
0
1
1
0


284
0
1
1
0
0
1
1
0
0
0
0
1
1
0


285
0
0
0
0
0
1
1
0
0
0
0
1
1
0


286
0
0
0
0
0
0
0
0
0
0
0
0
0
0


287
0
0
0
0
0
0
0
0
0
0
0
0
0
0


288
0
0
0
0
0
0
0
0
0
0
0
0
0
0


289
0
0
0
0
0
0
0
0
0
0
0
0
0
0


290
0
0
0
0
0
0
0
0
0
0
0
0
0
0


291
0
0
0
0
0
0
0
0
0
0
0
0
0
0


292
0
0
0
0
0
0
0
0
0
0
0
0
0
0


293
0
0
0
0
0
0
0
0
0
0
0
0
0
0


294
0
0
0
0
0
0
0
0
0
0
0
0
0
0









Samples Sam131 to Sam144 comprise at least one peptide which is characteristic of the SHV proteins. The bacteria present in samples Sam131 to Sam144 therefore express a beta-lactamase which confers on them a resistance to penicillins.
Sample Sam142 comprises a peptide specific to phenotype 2be. Therefore sample Sam142 is resistant to penicillins, to cephalosporins and to monobactams.
No peptide specific to phenotypes 2b and 2br is observed, no sample tested is identified as belonging only to these phenotypes.
The detection methods described in examples 6 to 30 are particularly advantageous because they make it possible to assay a large number of peptides and at the same time to detect the presence of one or more resistance mechanisms induced by one or more beta-lactamases.
Furthermore, the detection is performed in a short time, less than one hour. In fact, only the part of the gradient between 3 and 34 minutes is useful to the analysis. Furthermore, the retention times of the assayed peptides are all below 34 minutes.
In addition, the detection methods described in examples 6 to 30 are more advantageous than the molecular biology methods because they detect the product of the expression of the genes, and not the genes themselves. The detection of a resistance may not have any clinical meaning if this gene is not expressed, or it if is expressed too weakly to lead to an effective resistance. The detection of a peptide characterising a protein characteristic of a resistance mechanism does not have this disadvantage.
Surprisingly, the above examples show that it is possible to attain by mass spectrometry the sensitivity necessary for the specific detection of the existence of a mechanism of resistance to at least one antimicrobial of a microorganism contained in a sample, without employing an amplification method as is usually the case when molecular biology methods are used.
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## Claims

1. A method of detecting a TEM protein in a sample, comprising:
subjecting the sample to MS/MS spectrometry in MRM mode and detecting whether one or more TEM fragments selected from the group consisting of SEQ ID NOS: 166-230, 232-257, 259-261, 1923, 1927, and 1928 is present, wherein detection of any of the TEM fragments by the MRM mass spectrometry indicates the presence of TEM protein in the sample.

2. The detection method according to claim 1, further comprising, before performing MS/MS spectrometry in MRM mode, digesting proteins to produce peptides in the sample.

3. The detection method according to claim 2, wherein the digestion is performed by an enzyme.

4. The detection method according to claim 3, wherein the enzyme is trypsin.

5. The detection method according to claim 1, wherein the one or more TEM fragments is selected from the group consisting of SEQ ID NOS: 166-174, 180, 181, 186-203, 212-217, 219, 220, 223-230, 241-243, 250-255, 259-261, 1927, and 1928.