Exhibit 10.1


 








AMENDMEN OF  SOLICITATION/MODIFICATION  OF CONTRACT 1 1 .  CONTRACT  ID CODE OF  PAGES I I : 2 2.  AMENDMENT  MODIFICATION NO . 0010 3.  EFFECTIVE DATE 03/19/2018 4 .  REQUISITION/PURCHASE  REQ. NO . , 5 .  PROJECT  NO .  (If app/iible) 6. ISSUED  BY CODE ASPR - BA RDA ASPR - BAR b A 200  In d e oend e nce  Ave .,  S.W. Room  640 G W ash in gt  pn  DC 20201 7.  ADMINISTERED BY  (lfothertlian  Item 6) COD E SP R - B ARtj A O l ASPR - BARDA 33 0  I nd ep end e nce  Av e ,  SW,  Rm G644 Wash in g to n  DC  20201 8.  NAME  AND  ADDRESS  OF  CONTRACTOR  /No.,  street,  county,  State  and 2/PCodeJ BIOCRYST  PHARM AC EUTICALS,  INC.  7 2 6 6 13   BIOCRYST  PHARMACEUTICALS, I NC. 4505  EM P I  ROR  BLVD  STE 200 DURHAM  N< 2770 38 457 (X)  9A  AMENDMENT  OF  SOLICITATION NO . " - ' -- CODE 721 n 6 13 FACILITY CODE 98  .  DATED  (SEE  ITEM 11) X  10A .  MODIFICATION  OF  CONTRACT/ORDER NO . HHSO100201500007C 108  .  DATED  (SEE  ITEM 13) 03 / 27 /2015 11.  THIS  ITEM  ONLY  APPLIE  l  TO  AMENDMENTS  OF SOLICITATIONS The  above n   mbered  solicitat ion  is  amended  as  set  forth in  Item  14.  The  h our  and  dat,  ,s pecified     for  receipt of Offers i s extended . is  n ot  extended   Offers  m us t  ,  cknowledge receipt  of  this  amendment  prior  to the  hour  and  date  specified  l 1  the  solicitation  or  as  amended  .  by  ore  of  the  following  methods:  (a)  By  completing   Items  8  and    5 , and returning copies  of the  amendment ;  (b)  By  acl  i , owledging  receipt  of  this  amendment on  each  copy  of the  offer  submitted  ,  or  (c) By separate  let!  r  or  telegram  which  includes  a reference to  the solicitation  and  amendmen  numbers. FAILURE  OF  YOUR  ACKNOWLEDGEMENT  TO BE RECEIVED  AT   THE  PLACE  D ES IGNATED  FOR  THE  RECEIPT  OF  OFFERS  PRIOR TO  THE  HOUR  I  Im  DATE  SPECIFIED  MAY  RESULT  IN  REJECTION  OF  YOUR  OFFER  I f by virtue  of this  am  e ndment  you  desim  to  change  an  offer  already  submitte  d  ,  such  change  may  be  made  by  telegram  or  letter,  provided  each  telegram or  letter  makes refe re nce,  to the  solicitation  and  this  amendme n t ,  an d  is  received  orior  to the  ooenina  hem  and  date soecified. Net D e cr ease: - $ 3 , 600 , 68 6 . 00 12  ACCOUNT  NG  AND  APPROPRIATION  DATA  / I  /  requi red) S ee S ch edule 13 .  THIS  ITEM  ONLY  APPLIES  TO  MODIFICATION  OF  CONTRACTS/I  / ROER  S .  IT  MODIFIES  THE CONTRACT/ORDER  N,O.  AS  DESCRIBED IN  ITEM 14. CHEC K ONE A.  THIS  C HANGE  ORDER  NO. IN ORDER IS   ITEM 10A ISSUED  PURSUANT TO : (Specify authorit i' THE CHANGES SET FORTH IN ITEM 14 ARE M AD E IN THE CONTRACT B .  THE  ABOVE  NUMBERED  CONTRACT/ORDER  IS  MODIFIED  TO RE  I - ECT  THE  ADMINISTRATIVE  CHANGl:S  (such  as  chang es  in paying  office , j appropriation  date,  etc.)  SET  FORTH  IN  ITEM  14,  PURSUANT  TO  Tr  I:  AUTHORITY  OF  FAR 43.103(b). C.  THIS  SUPPLEMENTAL  AGREEMENT  IS  ENTERED INTO PURSUAN  TO  AUTHORITY OF: X D .  OTHER  (Specify  type  of  modification  and authority) Mutu a l  Agr e ement  of the Parties and  FAR 52.217 - 7 ! I I E . IMPORlAN  : Contractor ! K is         not . is    required  to  sign  this  docurhent  and  return    _      _      _    _     _ . _ .  _  _ copies  to  the  issuing office . - 1 - _ . 4  D_E_S_CI  F_ ; - R - I  O_NO  F_A_M_E_N_ED_N M/TM _ O_DI_  F I C_A_TI  O_ - N - (  - 0 - rg_a_niz - _ed _ by  _ U  C_F_s_etci_onh - e - ac - +_   tgJ_s, - in_c/u_ - - d _ in g_s_o/ - ic - it  a - - lol . - n" - co_ - t  na, _ - ct  subje'CIm a  tter  where feasible.) Tax ID N umber: 62 - 1413 17 4 I DUNS Nutber : 618 19 4 609 Deliver y  Location Code  : HHS / OS/ASPR   HHS/OS/ SPR 200 CS S W WA S HIN G ON DC 2 0 20 1 US I   I FOB:  De tination P er iod bf Perform a nce: 0 3/31/2 01 5 to 1 0/ 31 / 2 018 ' Chang e i it em 3 to read as follows (amount s h o1; n is the obligated 2 , mount):   Contin ed ... Except as  pr pv ided  herein  ,  all  terms  and  conditions of  the  document  refer enced  i n  Item  .  A  or  1 DA ,  as  heretofore  changed ,  remains  unchan11ed  and  in  full  force  and  effec . t 1 5  A . NAM  E  fND  TITLE  OF  SIGNER  (Type  or print ) 16A.  NAME  AND  TITLE OF  CONTRACTING  OFFICER  (Type  or print) T HOMAS  P.  HASTING S 158. CONTfVICTOR/OFFEROR !  (Signature  of  person  authorized  to sign) 15C  .  DATE SIGNED 1 6C . DPIJ  S  GNL "3/'/1/zaljl NSN  754 0 - 0i - 152 - 8070 Prev io us  edi  io n unusable 16B .  UNITED  STATES  OF AMERICA '. . ,1/ -- . _ ,. _ 21; (Signature  of  Contracting Officer) STANDARD  FORM  30  ( R  V 10 - 83) Prescribed  b y  GSA   FAR  (4 8  C FR) 53 . 243



      


     


    



. 1 REFERENC E N O . OF DOCUMENT BEIN G CONT I l/ED CONTINUATION SHE  ET I  HH S0100201500007C/0010 OF I 2 NAME  OF  OFFEROR  OR CONTRACTOR B IOCRYST  PHARMACEUTICALS,  I NC. 726613 · ITEM NO (A) SUPPLIES/SERVICES (B) QUANTITY UNI T (C) (D) UNIT PRICE (E) AMOUNT (F) 3 Option  2  Non - linical  NOA - enabl  i ng  Tc  x icology IM Obligated  Amount: - $2,329,617.00 Accounting In fo: 2015 .1 990500.25103  Appr.  Yr .:  20 15  C  N:  1990500  O bo  ect  CJ  a  s  , : 25103 Funded :  - $2,329, 617.00 Cancel  Item  6  in  its entirety. - 2, 32 9, 617 . 00 NSN 7540 - 0·l - 152 - 8067 OPTIONAL  FORM  336 (4 - 86) Sponsored  by GSA FAR  (48  CFR \ 53 . 110