EX-10.1




 Exhibit 10.1 
  





 
 September 28, 2018 

Maximo F. Nougues 
 via
E-mail 
  

	Re:	 EMPLOYMENT OFFER LETTER 



Dear Maximo: 
 Puma Biotechnology, Inc., a Delaware corporation
(the “Company”) is pleased to offer you the Full-Time, Exempt position of Chief Financial Officer of the Company, with terms as noted below. Please confirm your acceptance of this offer by signing and returning a copy of this
letter on or before September 28, 2018: 
 1. EFFECTIVE DATE,
POSITION, DUTIES AND RESPONSIBILITIES. The terms will become effective on the date you start your employment (the “Effective Date”), which shall be no
later than November 5, 2018. As of the Effective Date, the Company will employ you as its Chief Financial Officer. In such capacity, you will have such duties and responsibilities as are normally associated with such
position. Your duties may be changed from time to time by the Company in its discretion. You will report to the President and CEO or such other individual as the Company may designate, and will work at the Company’s offices located in
Los Angeles, California, or such other location as the Company may designate, except for travel to other locations as may be necessary to fulfill your responsibilities. Although your initial title and duties are described above, the Company
may assign you additional or different duties and/or titles from time-to-time. 

2. BASE COMPENSATION. During your employment with the Company, the Company will pay you a
base salary of $445,000 per year (the “Base Salary”), less payroll deductions and all required withholdings, payable in installments in accordance with the Company’s normal payroll practices (but in no event less often
than monthly) and prorated for any partial pay period of employment. Your Base Salary may be subject to adjustment pursuant to the Company’s policies as in effect from time to time. 

3. ANNUAL BONUS. In addition to the Base Salary set forth above, you will be eligible to
receive an annual discretionary cash bonus (pro-rated for any partial year of service), based on the attainment of performance metrics and/or individual performance objectives, in each case, established and
evaluated by the Company in its sole discretion (the “Annual Bonus”). Your target Annual Bonus shall be 40% of your Base Salary, but the actual amount of your Annual Bonus may be more or less (and may equal zero), depending
on the attainment of applicable performance criteria. Payment of any Annual Bonus(es), to the extent any Annual Bonus(es) become payable, will be contingent upon your continued employment through the applicable payment date. 

  
 10880 Wilshire Blvd.
Suite 2150 Los Angeles, CA 90024 
 424.248.6500 Phone 424.248.6501 Fax 












 4. STOCK OPTIONS. In connection with
entering into this offer letter, following the commencement of your employment with the Company and provided that you are employed by the Company on the date of award, (“Award Date”), the Company will award you 90,000 stock
options representing the right to receive shares of the Company’s common stock (the “option”) (as determined in accordance with the Company’s 2017 Inducement Plan). If the options are granted then, subject to your continued
employment with Company through the applicable vesting date, 1/3rd of the shares underlying the option will vest on the first anniversary of the vesting date and 1/36th of the shares underlying the option will vest on each month anniversary of the vesting date thereafter. Subject to the foregoing, the terms and conditions of the option must be approved by the
Compensation Committee or the Board of Directors, or a subcommittee thereof, and will be set forth in a separate award agreement in such form as is prescribed by the Company, to be entered into by the Company and you. 

5. Signing Bonus. In connection with entering into this offer letter, you will be paid a signing bonus of $550,000 (the “Signing
Bonus”) within twenty days after the Effective Date. You and the Company acknowledge and agree that the Signing Bonus will not be earned unless and until you are continuously, actively employed by the Company through the fourth anniversary of
the Effective Date, subject to the provisions below of this section concerning the effect of termination on or before the fourth anniversary of the Effective Date. If your employment is terminated by the Company with Cause at any time prior to or on
the first anniversary of the Effective Date, or by you without cause or without Good Reason (as defined in Section 7 below) prior to or on the first anniversary of the Effective Date, you will not be entitled to retain any portion of the
Signing Bonus and you will be obligated to immediately repay to the Company the Signing Bonus, in full, on the date of termination. In the event that your employment is terminated by the Company with Cause or by you without cause or without Good
Reason: (a) after the first anniversary of the Effective Date, but prior to or on the second anniversary of the Effective Date, the Company will allow you to retain 25% of the unearned bonus, and you hereby agree to repay to the Company, on the
date of termination, 75% of the bonus; or (b) after the second anniversary of the Effective Date, but prior to or on the third anniversary of the Effective Date, the Company will allow you to retain 50% of the unearned bonus, and you hereby
agree to repay to the Company, on the date of termination, 50% of the bonus; or (c) after the third anniversary of the Effective Date, but prior to or on the fourth anniversary of the Effective Date, the Company will allow you to retain 75% of
the unearned bonus, and you hereby agree to repay to the Company, on the date of termination, 25% of the bonus. In the event that your employment is terminated by the Company or by you for any reason after the fourth anniversary of the Effective
Date, you will be entitled to retain 100% of the bonus. For sake of clarity, if your employment terminates due to your disability or death at any time, such termination shall not be subject to the above provisions and you or your estate will be
entitled to retain 100% of the bonus. For purposes of this Section 5 only, Cause shall mean (1) your conviction or plea of nolo contender to a misdemeanor involving moral turpitude or any felony, (2) your commission of any act
of theft, embezzlement or misappropriation of Company assets, (3) your material breach of any agreement with the Company, (4) your failure to follow the reasonable and lawful written direction of any superior, provided that you are given
five days notice and opportunity to cure such failure, if curable, prior to termination, (5) your willful failure to perform the essential duties of your position, or (6) your commission of any act of unlawful discrimination, harassment or
retaliation. This does not alter the at-will nature of your employment. 

  
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 5. BENEFITS AND VACATION.
You will be eligible to participate in all health, welfare, savings and retirement plans, practices, policies and programs maintained or sponsored by the Company from time to time for the benefit of its similarly situated employees, subject to the
terms and conditions thereof. To the extent that you properly elect to participate in the Company’s applicable medical, dental and/or prescription benefit plans, the Company will pay the premiums for you and your dependents under such plans
while you remain employed by the Company, provided, however, that the Company shall have no obligation to pay any such premiums if doing so would result in a violation of law and/or the imposition of penalty or excise taxes on the Company. In
addition, you will be eligible for other standard benefits, such as sick leave, 5 weeks vacations and holidays, in each case, to the extent available under, and in accordance with, Company policy applicable generally to other similarly situated
employees of the Company. Notwithstanding the foregoing, nothing contained in this Section 6 shall, or shall be construed so as to, obligate the Company or its affiliates to adopt, sponsor, maintain or continue any benefit plans or programs at
any time. 
 6. TERMINATION. 

(a) If your employment with the Company is terminated by the Company without Cause or by you for Good Reason (each, a “Qualifying
Termination”), and you execute and fail to revoke during any applicable revocation period a general release of all claims against the Company and its affiliates in a form reasonably acceptable to the Company (the “Release”)
within 60 days following such termination of employment, then you shall be entitled to receive (i) an amount (the “Severance”) equal to your Base Salary at the rate in effect immediately prior to your date of termination during
the period of time commencing on the termination date and ending on the 12-month anniversary of your termination date, (ii) if you timely elect to receive continued healthcare coverage pursuant to the
provisions of the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”), the Company shall directly pay, or reimburse you for, the premium for you and your covered dependents through the earlier of
(A) the 12-month anniversary of your termination date and (B) the date you and your covered dependents, if any, become eligible for healthcare coverage under another employer’s plan(s) and
(iii) if the Qualifying Termination occurs on or within 18 months following a Change in Control (as defined in the Plan), all outstanding Company equity awards held by you on your date of termination shall immediately become fully vested and,
to the extent applicable, exercisable. For the avoidance of doubt, all such equity awards will remain outstanding and eligible to vest following your date of termination shall actually vest and become exercisable (if applicable) and non-forfeitable upon the effectiveness of the Release. The Severance shall be made in substantially equal installments in accordance with the Company’s standard payroll policies, less applicable withholdings,
with such installments to commence on the first payroll date following the 60th day following your date of termination, with the first installment to include any amount(s) that would have otherwise been paid prior to such first payroll date. In
addition, (A) if any plan pursuant to which the benefits in subsection (ii) are provided is not, or ceases prior to the expiration of the 

  
 3 












 
period of continuation coverage to be, exempt from the application of Section 409A (as defined below) under Treasury Regulation
Section 1.409A-1(a)(5), or (B) the Company is otherwise unable to continue to cover you under its group health plans without incurring penalties (including without limitation, pursuant to
Section 2716 of the Public Health Service Act), then, in either case, an amount equal to each remaining Company subsidy shall thereafter be paid to you in substantially equal monthly installments over the continuation coverage period (or the
remaining portion thereof). 
 (b) For purposes of this offer letter, “Cause” shall have the meaning set forth in the Plan.

 (c) For purposes of this offer letter, “Good Reason” shall mean the occurrence of any one or more of the following events
without your prior written consent, unless the Company corrects in all material respects the circumstances constituting Good Reason (provided such circumstances are capable of correction) in accordance with the correction provisions described below:

 (i) a material diminution in your Base Salary, excluding any reduction applicable equally to all executive officers of the Company
following a material decline in the Company’s earnings, public image, or performance; 
 (ii) a material diminution in your authority,
duties or responsibilities; or 
 (iii) a change in the geographic location at which you must perform services to a location that is greater
than 50 miles from the Company’s principal place of business as of the Effective Date; 
 provided, however, that no termination shall be
deemed a termination by you for Good Reason unless and until (x) you provide the Board with written notice of the circumstances constituting Good Reason within 90 days after the date that you first become aware of the existence of such
circumstances; (y) the Company fails to correct the circumstance so identified within 30 days after the receipt of such notice (if capable of correction); and (z) the effective date of your termination of employment occurs no later than 90
days after the date that you first become aware of the event or circumstances constituting Good Reason. 
 (d) No amount that is deferred
compensation subject to Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) shall be payable pursuant to this offer letter unless your termination of employment constitutes a “separation from
service” from the Company within the meaning of Section 409A of the Code and the Department of Treasury regulations and other guidance promulgated thereunder (“Section 409A”). For purposes of
Section 409A, your right to receive any installment payments under this offer letter shall be treated as a right to receive a series of separate payments and, accordingly, each such installment payment shall at all times be considered a
separate and distinct payment. 

  
 4 












 (e) Notwithstanding the foregoing, no compensation or benefits, including without limitation
any severance payments or benefits described above, shall be paid to you during the 6-month period following your “separation from service” from the Company if the Company determines that paying such
amounts at the time or times indicated in this letter would be a prohibited distribution under Section 409A(a)(2)(B)(i) of the Code. If the payment of any such amounts is delayed as a result of the previous sentence, then on the first business
day following the end of such 6-month period (or such earlier date upon which such amount can be paid under Section 409A without resulting in a prohibited distribution, including as a result of your
death), the Company shall pay you a lump-sum amount equal to the cumulative amount that would have otherwise been payable to you during such period. 

7. CONFIDENTIAL AND PROPRIETARY INFORMATION. This offer of
employment is contingent upon your execution of the Proprietary Information and Inventions Agreement, attached hereto as Exhibit A. 

8. NON-SOLICITATION. You further agree that during
the term of such employment and for one (1) year after your employment is terminated, you will not directly or indirectly solicit, induce, or encourage any employee, consultant, agent, customer, vendor, or other parties doing business with the
Company to terminate their employment, agency, or other relationship with the Company or to render services for or transfer their business from the Company and you will not initiate discussion with any such person for any such purpose or authorize
or knowingly cooperate with the taking of any such actions by any other individual or entity. 
 9. AT-WILL EMPLOYMENT; AMENDMENT. Your employment with the Company is “at-will,” and either you or the
Company may terminate your employment for any reason whatsoever (or for no reason) upon written notice of such termination to the other party. This at-will employment relationship cannot be changed except in a
writing signed by you and an authorized representative of the Company. This agreement may not be amended except by a signed writing executed by the parties hereto. 

10. COMPANY RULES AND REGULATIONS. As an employee of the
Company, you agree to abide by all Company rules, regulations and policies as set forth in the Company’s employee handbook or as otherwise promulgated. 

11. WITHHOLDING. The Company may withhold from any amounts payable under this offer letter such
Federal, state, local or foreign taxes as shall be required to be withheld pursuant to any applicable law or regulation. 
 12.
ENTIRE AGREEMENT. As of the Effective Date, this offer letter, together with the Stock Option Agreement and Proprietary Information and Inventions Agreement, comprises the final, complete and
exclusive agreement between you and the Company with respect to the subject matter hereof and replaces and supersedes any and all other agreements, offers or promises, whether oral or written, made to you by any representative of the Company. You
agree that any such agreement, offer or promise between you and any representative of the Company is hereby terminated and will be of no further force or effect, and you acknowledge and agree that upon your execution of this offer letter, you will
have no right or interest in or with respect to any such agreement, offer or promise. 
 13. CHOICE OF
LAW. This offer letter shall be interpreted and construed in accordance with California law without regard to any conflicts of laws principles.  

  
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 14. PROOF OF RIGHT TO
WORK. As required by law, this offer of employment is subject to satisfactory proof of your right to work in the United States. 

15. BACKGROUND CHECK AND DRUG
SCREENING. This offer of employment is expressly contingent upon your completion of a pre-employment background check conducted by an outside service bureau
and a drug screening test, in each case with results that are satisfactory to the Company in its sole discretion. Refusal to submit to the background check or drug screening test will result in your disqualification from further employment
consideration. In addition, failure to successfully complete the background check or drug screening test will cause this offer of employment to be withdrawn, or your employment to be terminated if you already have started work. 

[SIGNATURE PAGE FOLLOWS] 
  

  
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 Please confirm your agreement to the foregoing by signing and dating the enclosed duplicate original of
this offer letter in the space provided below for your signature and returning it to the Company’s President and Chief Executive Officer. Please retain one fully-executed original for your files. 

 

			
	Sincerely,
	
	Puma Biotechnology, Inc.
	a Delaware corporation
		
	By:	 	 /s/ Alan H. Auerbach

	Name: Alan H. Auerbach
	Title: President and Chief Executive Officer


  

			
	Accepted and Agreed,
	this 2nd day of October, 2018
		
	By:	 	 /s/ Maximo F. Nougues

		 	Maximo F. Nougues












 EXHIBIT A 

PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 











 PUMA BIOTECHNOLOGY, INC. 

PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 

In consideration of my employment by Puma Biotechnology, Inc. (the “Company”) (the definition of “Company”
for the purposes of this Agreement shall include Puma Biotechnology, Inc., its affiliates, and subsidiaries) and access to Proprietary Information (defined below) being given to me by the Company, I hereby agree to this Proprietary Information and
Inventions Agreement as of 10/15/2018 (the “Agreement”), as follows: 
 1. Proprietary Information. The
term “Proprietary Information” shall mean all information received by me in the course of my employment by the Company, including without limitation all trade secrets, inventions, confidential knowledge, data or any other
information or materials that the Company treats or considers as proprietary, whether or not such Proprietary Information is patentable or copyrightable, however it is embodied and irrespective of whether it is labeled as “proprietary” or
“confidential”. By way of illustration but not limitation, “Proprietary Information” includes (a) inventions, trade secrets, know-how, ideas, confidential knowledge,
improvements, discoveries, developments, processes, designs, techniques, formulas, formulations, source and object codes, data, programs, trademarks and works of authorship; organisms, plasmids, cosmids, bacteriophages, expression vectors,
cells, cell lines, tissues, materials, substrates, media, delivery methods or transfection methods and other biological materials and the progeny and clones of the foregoing biological materials, assays, compounds, peptides, proteins, DNA, RNA, and
their constructs, and sequence, amino acid, genomic, and structural information relating thereto; crystals, optically active materials, ceramics, metals, metal oxides and organic and inorganic chemical and other physical materials and derivatives
and salt forms of the foregoing (hereinafter the Proprietary Information described in clause (a) shall collectively be referred to as “Inventions”); (b) information regarding the Company’s plans for research, regulatory,
development, manufacturing, engineering, marketing and selling efforts, the Company’s business plans and plans for new products, budgets and unpublished financial statements, licenses, contractual arrangements, prices and costs, suppliers,
distributors and customers; and information regarding the skills, background and compensation of other employees of the Company and (c) all Third Party Information (as defined in Section 3). 

2. Recognition of Company’s Rights; Nondisclosure. I acknowledge that as a result of my responsibilities at the Company, I
am likely to be exposed and given access to the Proprietary Information of the Company. I understand and agree that my access to the Proprietary Information is for the sole and exclusive purpose of producing technology and performing other work for
the benefit of the Company and that the Company has a substantial ongoing investment in the development and acquisition of such Proprietary Information, which investment would be irreparably and adversely affected if this Agreement were breached. At
all times during the term of my employment and thereafter, I will hold the Company’s Proprietary Information in the strictest confidence and will not, except with the written permission of the Chief Executive Officer of the Company, disclose
(which term throughout this Agreement includes, but is not limited to, lecturing upon or publishing) any such Proprietary Information to anyone other than Company personnel who need to know such information in connection with their work for the
Company or use such Proprietary Information except in connection with any work for the Company. 











 I further acknowledge that Proprietary Information is solely the property of the Company and
I agree that at no time either during the period of my employment nor thereafter will I challenge or engage in any other acts which question or impugn the validity or ownership of the Company’s rights in any Proprietary Information. I further
acknowledge that any and all improvements or modifications to Proprietary Information that I generate, make, conceive, develop or reduce to practice or to specific form, whether alone or in conjunction with others, either during or after the period
of my employment with the Company shall constitute Proprietary Information. 
 3. Third Party Information. I
understand that the Company has received and in the future will receive from third parties confidential or proprietary information (“Third Party Information”) that is subject to a duty on the Company’s part to maintain the
confidentiality of such information and to use it only for certain limited purposes. During the term of my employment and thereafter, I will treat all Third Party Information as Proprietary Information for purposes of this Agreement. 

4. Assignment of Inventions.  

(a) Except as provided below in Section 4(b) of this Agreement, I hereby assign to the Company all my right,
title and interest in and to any and all Inventions, whether or not patentable or registrable under copyright or similar statutes, that I make, conceive or reduce to practice, reduce to specific form or learn, either alone or jointly with others, in
the course of my employment by the Company, whether developed in whole or in part using the Company’s equipment, supplies, facilities, trade secret information or Proprietary Information; or relating at the time of conception or reduction to
practice to the Company’s business, or actual or demonstrably anticipated research or development of the Company; or resulting from any work performed by me for the Company (collectively, the “Employment Inventions”). I
recognize that this Agreement does not require assignment of any invention which qualifies fully for protection under Section 2870 of the California Labor Code (hereinafter “Section 2870”), which provides as
follows: 
 (i) Any provision in an employment agreement which provides that an employee shall assign, or offer to assign, any of his or her
rights in an invention to his or her employer shall not apply to an invention that the employee developed entirely on his or her own time without using the employer’s equipment, supplies, facilities, or trade secret information, except for
those inventions that either: 
 (1) relate at the time of conception or reduction to practice of the invention to the employer’s
business, or actual or demonstrably anticipated research or development of the employer; or 
 (2) result from any work performed by the
employee for the employer. 
 (ii) To the extent a provision in an employment agreement purports to require an employee to assign an
invention otherwise excluded from being required to be assigned under subdivision (a), the provision is against the public policy of California and is unenforceable. 

(b) I have set forth on Exhibit A attached hereto, a complete list of all restrictions, express or implied, which would prevent me from
complying with all of the requirements of Section 4(a) of this Agreement in whole or in part. If full disclosure of such restrictions, express or implied, in Exhibit A would cause me to violate any prior
confidentiality agreement, I understand that I am to describe such restrictions in Exhibit A at the most specific level possible without violating any such restrictions. Exhibit A is incorporated into this Agreement by reference as if
fully set forth herein. I will promptly inform the Company in writing of any such restrictions that arise between the time I sign this Agreement and the time my employment with the Company commences. 











 (c) I also assign to or assign as directed by the Company all my right, title and interest
in and to all Employment Inventions, full title to which is required to be in the United States by a contract between the Company and the United States or any of its agencies. 

(d) I acknowledge that all original works of authorship which are made by me (solely or jointly with others) within the scope of my employment
and which are protectable by copyright are “works made for hire,” as that term is defined in the United States Copyright Act (17 U.S.C., Section 101). 

5. Enforcement of Proprietary Rights. To assist the Company in exercising its ownership rights to all Proprietary
Information or Employment Inventions that I generate, make, conceive, reduce to practice or to specific form, alter or modify, I will, if requested by the Company, execute, verify and deliver assignments of all rights in the United States and
elsewhere, including but not limited to patent and copyright rights, in such Proprietary Information or Employment Inventions to the Company or its designees. I will also assist the Company in every proper way to obtain and from time to time enforce
its United States and foreign rights relating to Proprietary Information or Employment Inventions in any and all countries, irrespective of whether I had any role in the development or modification of such Proprietary Information or Employment
Inventions. To that end, I will execute, verify and deliver such documents and perform such other acts (including appearances as a witness) as the Company may reasonably request for use in applying for, obtaining, perfecting, evidencing, sustaining
and enforcing such proprietary rights and the assignment thereof to the Company. My obligation to assist the Company with respect to all its rights in Proprietary Information or Employment Inventions in any and all countries shall continue beyond
the termination of my employment, but the Company shall compensate me at a reasonable rate after my termination for the time actually spent by me at the Company’s request on such assistance. 

In the event the Company is unable for any reason, after good faith and all reasonable effort, to secure my signature on any document needed
in connection with the actions specified in this Section 5, I hereby irrevocably designate and appoint the Company and its duly authorized officers and agents as my agent and attorney in fact, which appointment is coupled
with an interest, to act for and in my behalf to execute, verify and file any such documents and to do all other lawfully permitted acts to further the purposes of the preceding paragraph thereon with the same legal force and effect as if executed
by me. I hereby waive and quitclaim to the Company any and all claims, of any nature whatsoever, which I now or may hereafter have for infringement of any proprietary rights assigned hereunder to the Company. 

6. Obligation to Keep Company Informed. I will promptly disclose to the Company fully and in writing and will hold in
trust for the sole right and benefit of the Company any and all Employment Inventions that I make, conceive, develop or reduce to practice or to specific form, whether alone or in conjunction with others, during or after the period of my employment
with the Company. In addition, after any termination of my employment, I will promptly disclose to the Company fully and in writing, the full particulars of all patent applications filed by me which disclose or claim Proprietary Information or
Employment Inventions. 











 I will also promptly disclose to the Company fully and in writing any inventions containing
or disclosing Proprietary Information that I believe fully qualify for protection under Section 2870; and I will at that time provide to the Company in writing all evidence necessary to substantiate that belief. I understand that the Company
will keep in confidence and will not disclose to third parties without my consent any proprietary information disclosed in writing to the Company pursuant to this Agreement relating to Inventions that qualify fully for protection under the
provisions of Section 2870. I will preserve the confidentiality of any Employment Invention that does not fully qualify for protection under Section 2870. 

7. Prior Inventions. The term “Prior Inventions” shall mean any and all inventions, trade secrets, know-how, know-how, ideas, confidential knowledge, improvements, discoveries, developments, processes, designs, techniques, formulas, formulations, source and object codes,
data, programs, trademarks and works of authorship; organisms, plasmids, cosmids, bacteriophages, expression vectors, cells, cell lines, tissues, materials, substrates, media, delivery methods or transfection methods and other biological materials
and the progeny and clones of the foregoing biological materials, assays, compounds, peptides, proteins, DNA, RNA, and their constructs, and sequence, amino acid, genomic, and structural information relating thereto; crystals, optically active
materials, ceramics, metals, metal oxides and organic and inorganic chemical and other physical materials and derivatives and salt forms of the foregoing, which I have, alone or jointly with others, conceived, developed or reduced to practice or
caused to be conceived, developed or reduced to practice prior to the commencement of my employment with the Company. To preclude any possible uncertainty over what is a Prior Invention, I have set forth on Exhibit B
attached hereto a complete list of all Prior Inventions that I consider to be in whole or part my property or the property of third parties, and that I wish to have excluded from the scope of this Agreement. If full disclosure of any such Prior
Invention on Exhibit B would cause me to violate any prior confidentiality agreement, I understand that I am to describe such Prior Inventions in Exhibit B at the most specific level possible without violating any
such prior confidentiality agreements. Exhibit B is incorporated into this Agreement as if fully set forth herein. I will promptly inform the Company in writing of any Prior Inventions that occur between the time I sign this Agreement and the
time my employment with the Company commences. 
 8. Unauthorized Use or Disclosure. I shall immediately notify my
supervisor or any officer of the Company if I learn of any possible unauthorized use or disclosure of Proprietary Information and shall cooperate fully with the Company to enforce the provisions of this Agreement. 

9. Authorized Disclosure. Should I be subject to any governmental, administrative or court order or action purporting to require
or authorize the disclosure of any Proprietary Information, in whole or in part, I will immediately notify the Company’s legal department and will immediately provide the Company with all documents and other pertinent information in my
possession or control to permit the Company to take such steps as it deems necessary in its sole discretion to block or pursue the confidentiality of such disclosure. 

10. Additional Activities. I agree that during the period of my employment by the Company I will not, without the Company’s
express written consent, engage in any employment or business activity other than for the Company, except as may be provided in any written agreement between me and an authorized officer of the Company with the Company executed as of the same date,
and for the period of my employment by the Company and for one (1) year after the date of termination of my employment by the Company, I will not use any Proprietary Information in order to (i) induce any employee of the Company to leave
the employ of the Company or (ii) solicit the business of any client or customer of the Company (other than on behalf of the Company) with whom I had contact during the course of my employment with the Company. 











 11. No Improper Use of Materials. I acknowledge that the Company forbids me to
use or disclose any information that is proprietary to any competitor of the Company or to any other third party. Therefore, during my employment by the Company, I will not use or disclose any confidential information or trade secrets, if any, of
any former employer or any other person to whom I have an obligation of confidentiality and I will not bring onto the premises of the Company any unpublished documents or any property belonging to any former employer or any other person to whom I
have an obligation of confidentiality unless consented to in writing by that former employer or person. To preclude any possible uncertainty, I have set forth on Exhibit C attached hereto, a complete list of all devices, materials, and
documents of a former employer or other person or institution to whom I have an obligation of confidentiality that may be used in providing services to the Company pursuant to the express written authorization of my former employer or such other
person. I will promptly notify the Company in writing of any devices, materials, and documents that are required to be set forth in Exhibit C that arise between the time I sign this Agreement and the time my employment with the Company
commences. Exhibit C is incorporated into this Agreement by reference as if fully set forth herein. In addition, I will not seek nor knowingly use any information from job applicants, Company employees or other third parties, including but
not limited to vendors, that is confidential to the present or former employers of such applicants or former employers of the employees or to such third parties. 

12. No Conflicting Obligation. I represent that my performance of all the terms of this Agreement and my position as an employee
of the Company does not and will not breach any agreement to keep in confidence information acquired by me in confidence or in trust prior to my employment by the Company. I have not entered into, and I agree I will not enter into, any agreement
either written or oral in conflict herewith. 
 13. Return of Company Materials. When I leave the employ of the Company, I will
deliver to the Company any and all copies and originals of drawings, notes, memoranda, lab notebooks, specifications, correspondence (including email and quickmail messages), devices, equipment, formulas, documents, molecules, cells, organisms,
plasmids, cosmids, bacteriophages, expression vectors, cell lines, peptides, proteins, DNA, RNA, and their constructs and other biological materials, and the progeny and clones of the foregoing biological materials and sequence, amino acid, genomic,
and structural information relating thereto; crystals, optically active materials, ceramics, metals, metal oxides and organic and inorganic chemical and other physical materials and derivatives and salt forms of the foregoing, and any other material
containing or disclosing any Inventions, Employment Inventions or Proprietary Information. I further agree that any property situated on the Company’s premises and owned by the Company, including disks and other storage media, quickmail, email,
voicemail, filing cabinets or other work areas, is subject to inspection by Company personnel at any time with or without notice. Prior to leaving, I will reasonably cooperate with the Company in completing and signing the Company’s
documentation for separating staff members. 
 14. Name and License. I hereby grant to the Company a non-exclusive worldwide license to use my name and likeness on or in connection with any advertising and promotional materials distributed by or on behalf of the Company in any medium while serving as an employee or
director of the Company or thereafter, if such materials describe my prior role as employee or director of the Company. 











 15. Potential Liability. I have been informed and acknowledge that the
unauthorized taking of the Company’s trade secrets (a) could result in civil liability under California Civil Code Section 3426, and that, if willful, could result in an award for triple the amount of the Company’s damages and
attorneys’ fees; and (b) is a crime under California Penal Code Section 499c(c), punishable by imprisonment for a time not exceeding one year, or by a fine not exceeding five thousand dollars ($5,000), or by both. 

16. Legal and Equitable Remedies. Because my services are personal and unique and because I may have access to and become
acquainted with the Proprietary Information of the Company, and due to the irreparable injury which would be suffered by the Company as a result of a breach of this Agreement, the Company shall have the right to enforce this Agreement and any of its
provisions by injunction, specific performance or other equitable relief, without bond and without prejudice to any other rights and remedies that the Company may have for a breach of this Agreement. 

17. Notices. Any notices required or permitted hereunder shall be given to the appropriate party at the address specified below
or at such other address as the party shall specify in writing. Such notice shall be deemed given upon personal delivery to the appropriate address or if sent by certified or registered mail, three (3) days after the date of mailing. 

18. Employment at Will. I understand and agree that my employment with the Company is
at-will. Therefore, my employment can terminate, with or without cause, and with or without notice, at any time, at my option or the Company’s option, and that the Company can terminate or change all
other terms and conditions of my employment, with or without cause, and with or without notice, at any time. I understand that the nature of my employment relationship with the Company will be governed by this Section 18
and that this Section 18 constitutes the entire agreement, arrangement and understanding between me and the Company on this subject matter and supersedes any prior or contemporaneous agreement, arrangement, and
understanding on this subject matter. This at-will relationship will remain in effect throughout my employment with the Company or any of its subsidiaries or affiliates, unless it is modified by a written
agreement signed by both the Company’s President and me which expressly alters it. This at-will relationship may not be modified by any oral or implied agreement, or by any Company policies, practices or
patterns or conduct. 
 19. General Provisions. 

(a) Governing Law and Forum. This Agreement will be governed by and construed according to the substantive laws of
the State of California without resort to conflict of law principles and I hereby consent to the jurisdiction of the courts of California, both state and federal, for any claim sounding in tort or contract or created by state or federal law related
in any way to my or the Company’s rights and obligations under the Agreement. 
 (b) Entire Agreement. This
Agreement, including all exhibits hereto, is the final, complete and exclusive agreement of the parties with respect to the subject matter hereof and supersedes and merges all prior discussions between us. No modification of or amendment to this
Agreement, nor any waiver of any rights under this Agreement, will be effective unless in writing signed by the party to be charged. Any subsequent change or changes in my duties, salary or compensation will not affect the validity or scope of this
Agreement. As used in this Agreement, the period of my employment includes any time during which I may be retained by the Company as a consultant. 











 (c) Severability. Whenever possible, each provision of this Agreement
will be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be prohibited by or invalid under applicable law, such provision will be ineffective only to the extent of such
prohibition or invalidity, without invalidating the remainder of this Agreement. 
 (d) Assignment. This Agreement may
not be assigned by me but is fully assignable by the Company. 
 (e) Successors and Assigns. This Agreement will be
binding upon my heirs, executors, administrators and other legal representatives and will be for the benefit of the Company, its successors, and its assigns. 

(f) Survival. The provisions of this Agreement shall survive the termination of my employment and the assignment of this
Agreement by the Company to any successor in interest or other assignee. 
 (g) Waiver. No waiver by the Company of any
breach of this Agreement shall be a waiver of any preceding or succeeding breach. No waiver by the Company of any right under this Agreement shall be construed as a waiver of any other right. The Company shall not be required to give notice to
enforce strict adherence to all terms of this Agreement. 
 (h) Effective Date. Agreement shall be effective as of the
earliest of (1) the first day of my employment by the Company; or (2) the first day of my use of the facilities, technology, expertise, data or Proprietary Information of the Company; or (3) the day I sign this Agreement. 

(i) Descriptive Headings. The descriptive headings of this Agreement are for convenience only, and shall be of no force or
effect in construing or interpreting any of the provisions of this Agreement. 
 [Signature Page Follows] 











 



 
 I UNDERSTAND THAT THIS AGREEMENT AFFECTS MY RIGHTS TO INVENTIONS I MIGHT HAVE MADE DURING MY PAST
EMPLOYMENT, AND MAKE DURING MY EMPLOYMENT, AND RESTRICTS MY RIGHT TO DISCLOSE OR USE THE COMPANY’S PROPRIETARY INFORMATION DURING OR SUBSEQUENT TO MY EMPLOYMENT. 

I HAVE READ THIS AGREEMENT CAREFULLY AND UNDERSTAND ITS TERMS. I HAVE COMPLETELY FILLED OUT AND SIGNED EXHIBITS A, B, AND C TO THIS AGREEMENT
AS APPROPRIATE. 
 IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the day and year first set forth above.

  

									
	COMPANY:	 		 		 	
	 PUMA BIOTECHNOLOGY, INC.

a Delaware corporation
	 		 		 	
					
	By:	 	 /s/ Alan H. Auerbach
	 		 		 	 /s/ Maximo F. Nougues

	Name:	 	Alan Auerbach	 		 	        	 	Name: Maximo F. Nougues
	Title:	 	CEO and President	 		 		 	
					
	Address:	 	 10880 Wilshire Blvd, Suite 2150
 Los Angeles, CA
90024
	 		 		 	Address: Maximo F. Nougues

 [Signature Page to Puma Biotechnology, Inc. Proprietary Information and Inventions Agreement] 

 











 



 
 EXHIBIT A 

Puma Biotechnology, Inc. 
 10880 Wilshire Blvd, Suite 2150 

Los Angeles, CA 90024 
 Attention: Board of Directors 

Directors: 
 The following is a complete list of all restrictions
which would prevent me, in whole or in part, from assigning to or as directed by the Company (as defined in the attached Agreement) all my right, title and interest in and to any and all Employment Inventions (as required by
Section 4 of the Agreement): 
  

							
	                        	 	      X      	 		  	No restrictions.
				
		 	               	 	    	  	Restrictions:
		 		 		  	  

		 		 		  	  

				
		 	               	 		  	Number of additional sheets attached.

 Date: October 2, 2018 

 

	
	Very truly yours,
	
	 /s/ Maximo F. Nougues

	Maximo F. Nougues


 Puma Biotechnology, Inc. Proprietary Information and Inventions Agreement 











 



 
 EXHIBIT B 

Puma Biotechnology, Inc. 
 10880 Wilshire Blvd, Suite 2150 

Los Angeles, CA 90024 
 Attention: Board of Directors 

Directors: 
 The following is a complete list of all Prior
Inventions (as defined in the attached Agreement): 
  

							
	                        	 	      X      	 		  	 No Prior Inventions

				
		 	               	 	    	  	 Prior Inventions:

		 		 		  	  

		 		 		  	  

				
		 	               	 		  	Number of additional sheets attached.

 Date: October 2, 2018 

 

	
	Very truly yours,
	
	 /s/ Maximo F. Nougues

	Maximo F. Nougues


 Puma Biotechnology, Inc. Proprietary Information and Inventions Agreement 











 EXHIBIT C 

Puma Biotechnology, Inc. 
 10880 Wilshire Blvd, Suite 2150 

Los Angeles, CA 90024 
 Attention: Board of Directors 

Directors: 
 I propose to bring or have already brought to my
employment with the Company (as defined in the attached Agreement) the following devices, materials and documents of my former employer(s) or other person(s) or institution(s) to whom I have an obligation of confidentiality that are not generally
available to the public, which materials and documents may be used in providing services to the Company pursuant to the express written authorization of my former employer(s) or such other person(s) or institution(s) (copies of all such
authorizations are attached hereto): 
  

							
	                        	 	      X      	 		  	 No materials.

				
		 	               	 	    	  	 Materials:

		 		 		  	  

		 		 		  	  

				
		 	               	 		  	Number of additional sheets attached.
				
		 	               	 		  	 Number of pages of authorizations attached.


 Date: October 2, 2018 
  

	
	Very truly yours,
	
	 /s/ Maximo F. Nougues

	Maximo F. Nougues


 Puma Biotechnology, Inc. Proprietary Information and Inventions Agreement