Exhibit 10.1  SUPPLY AGREEMENT  THIS AGREEMENT (the Agreement), entered into as of this
24th day of January 2006 (the Effective Date), by and among Cambrex Charles
City, Inc. (CCC), a corporation organized under the laws of Iowa with a place
of business at 1205 11th Street, Charles City, Iowa 50616-3466,
Genzyme Corporation, a Massachusetts corporation with a place of business at 500 Kendall Street, Cambridge,
Massachusetts 02142 (Genzyme or Purchaser).  W
I T N E S S E T H:  WHEREAS, on November 9, 1999, Salsbury Chemicals, Inc.
(nka Cambrex Charles City, Inc.) and GelTex Pharmaceuticals, Inc. entered into
a Supply Agreement governing the supply of Polyallylamine Hydrochloride (PAA)
to GelTex by CCC (the 1999 Agreement).  WHEREAS, Genzyme is the successor in interest to
GelTex Pharmaceuticals, Inc. under the 1999 Agreement.  WHEREAS, Genzyme sublicensed certain patent rights
(the Patent Rights) obtained from Nitto Boseki Co. Ltd. (Nittobo) to CCC
pursuant to the terms of a sublicense agreement dated July 10, 1997 (the Sublicense
Agreement) and CCC has experience in the production of PAA, as further
described in Exhibit A hereto (the Product);  WHEREAS, Cambrex Karlskoga, a corporation
organized under the laws of Sweden with a place of business at SE-691 85
Karlskoga, Sweden (Karlskoga) and Genzyme assigned the Patent Rights to
Karlskoga pursuant to the terms of the Sublicense Agreement;  WHEREAS, for purposes of this Agreement,
the term Affiliate shall mean any corporation or other entity that controls,
is controlled by, or is under common control with a party. A corporation or
other entity shall be regarded as in control of another corporation or entity
if it owns or directly or indirectly controls more than fifty percent (50%) of
the voting stock or other ownership interest of the other corporation or
entity, or if it possesses directly or indirectly, the power to direct or cause
the direction of the management and policies of the corporation or other entity
or the power to elect or appoint more than fifty percent (50%) of the members
of the governing body of the corporation or other entity;  WHEREAS, Genzyme requires the Product for the
production of certain non-absorbed phosphate binders (including Renagel® and
any other nonabsorbed phosphate binder produced by Genzyme) and a non-absorbed
cholesterol reducer (Cholestagel®) (hereinafter be referred to collectively as End
Products);  WHEREAS, the primary raw material for the manufacture
of Product is monoallylamine (MAA);  WHEREAS, the End Products may be manufactured by
certain third party manufacturers identified in writing to CCC (the Contract
Manufacturers) and will be marketed and sold by certain third party
collaborators identified in writing to CCC (the Collaborators);  WHEREAS, CCC is willing to sell to Genzyme and
Genzyme, either directly or through its Contract Manufacturers, is willing to
purchase from CCC, Product manufactured by CCC in accordance with the price and
other terms set forth herein;


WHEREAS, Genzyme and CCC desire to extend its supply
relationship and replace the 1999 Agreement with this Agreement, effective on
the Effective Date hereof.  NOW,
THEREFORE, the parties hereto agree as follows:  ARTICLE
I MANUFACTURE
AND SALE  1.01Supply.During the term of this Agreement
and subject to the terms and conditions set forth herein, CCC shall manufacture
and supply to Genzyme and Genzyme shall purchase [                              ]*
of its annual requirements of the Product from CCC. For purposes hereof, Genzymes
annual requirements shall include the annual requirements of the Collaborators
and Contract Manufacturers having an obligation to obtain Product through
Genzyme. Genzymes Maximum Purchase Volume (MPV) in any one calendar year shall
be [                              ]*.
Should Genzyme's MPV exceed such amount, the parties shall work in good faith
to increase the capacity.  1.02Safety Stock.  During the Term of this
Agreement, CCC shall maintain a [                              ]*
of Product as safety stock; provided that Genzymes total annual purchase
volume exceeds [                        ]*.
Such amount shall be determined based on monthly average of the annual forecast
for Product to be delivered to Haverhill, U.K.  1.03Quality of Product.  CCC
agrees to manufacture the Product to meet the specifications set forth in
Exhibit A hereto (the Specifications), and in accordance with all applicable
regulatory requirements relating to the manufacture of the Product and the
terms and conditions of the Technical Agreement, which is attached hereto as
Exhibit B (the Technical Agreement), and shall not deviate in any way
whatsoever therefrom without the written permission of a duly authorized
representative of the Purchasers.  1.04Secondary Source of Supply.  Genzyme has qualified
Product produced at Karlskoga for use at Genzyme in Haverhill UK, and may
qualify other CCC Affiliates, as a secondary supplier of Product. CCC may only
use such secondary suppliers of Product qualified by Genzyme to manufacture
such portion [                              ]*
as CCC shall determine. In [                     ]*,
Genzyme will use commercially reasonable efforts to arrange for Product
manufactured at [                              ]*.
Notwithstanding its use of a secondary source of supply, CCC shall remain
obligated to supply Genzyme with the quantities of Product described in Section
1.01, and CCC shall be solely responsible for ensuring that all Product
manufactured for Genzyme, whether by CCC or another Affiliate of CCC, satisfies
the quality requirements and meets the warranties sets forth in this Agreement.
If requested by Genzyme, CCC shall use commercially reasonable efforts to cause
the secondary source to enter into a Technical Agreement with Genzyme in a timely
manner.  ARTICLE
II TERM  2.01Term.The term of this Agreement shall
commence on the Effective Date and shall terminate [                              ]*
(the Initial Term), and is not subject to earlier cancellation by either
party except as otherwise specifically provided herein.  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


2.02Renewal Term.The Agreement shall automatically
renew after the Initial Term and continue in effect for [            ]*
periods (each such period being a Renewal Term).  2.03Cancellation.Should either party desire to cancel
the Agreement at the end of the Initial Term or at the end of any Renewal Term,
then such party must provide written notice of cancellation to the other party [                              ]*
prior to the termination date of the Initial Term or the relevant Renewal Term,
as the case may be.  2.04Extension.CCC or Genzyme has the option to
open negotiations on the extension of this Agreement [              ]*
prior to its expiration.  ARTICLE
III PRICE,
ORDERS AND TERMS OF PAYMENT  3.01Price.The Price for the Product is as set
forth in Schedule 3.01 hereof. The Price for Product purchased from [                              ]*
through [                              ]*
shall be adjusted as set forth in Schedules 3.01 and 3.01a, hereof. The Price
for Product purchased from [                              ]*
through [                              ]*
shall be adjusted as set forth in Section 3.02 and Schedule 3.01.  3.02Price Revision January 1, 2007 -
December 31, 2013 Purchases.   The Price, excluding the
contribution of [              ]*
(the Base Price) will be subject to an annual [                              ]*
over the actual price determined for the prior year commencing on January 1,
2007, considering [                              ]*
as set forth in Schedule 3.01. Further, the portion of the Price [                              ]*,
will also be adjusted based upon the [                              ]*
for the upcoming year and [                              ]*.
At the end of each contract year, the [                              ]*
will be determined and any difference in projected price will be invoiced to
Genzyme or credit made to its account. The contribution for [                              ]*
is forecast to be [                    ]*
for each kilogram of Product produced, based upon a price of [            ]*
(plus freight, insurance and applicable duty) 
per kilogram of [               ]*.
Genzyme has the option to independently negotiate the price and supply of [                                       ]*.
The parties also agree to negotiate in good faith [                              ]*
in the event of [                              ]*.  3.03Rebate.If this Agreement is executed by the
parties by [                              ]*
(unless a later date is mutually agreed to by the parties) and if Genzyme
orders and takes title to at least [                   ]* of Product between [                              ]* and [                              ]* then CCC shall provide Genzyme a rebate of [                  ]*,
paid through a credit to the Genzyme account for Product.  3.04Projections.Genzyme or its Contract
Manufacturers shall issue at quarterly intervals a twelve (12) month non
binding forecast estimating its total requirements of Product from CCC
(Forecast). CCC will use these forecasts for planning purposes only, unless and
until such time as Genzyme issues a firm purchase order for delivery of
Product. If during any quarter, the quantity set forth in firm purchase orders
requested by Genzyme exceeds the most recent forecast provided for such quarter
by more than [                              ]*,
CCC shall use its best efforts to accommodate any increases in the quantity of
Product which Genzyme shall request under new purchase orders.  3.05Purchase Orders.Quarterly, Genzyme or its Contract
Manufacturers shall submit purchase orders for firm orders of Product with each
rolling forecast issued pursuant to Section 3.04, above. Such purchase orders
shall be firm orders covering the first three months of the  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


Forecast and set forth the
quantities of Product to be purchased, the delivery dates and shipping
instructions and place of delivery, and shall allow at least [                         ]*
days for delivery. Each purchase order issued hereunder shall be governed by
the terms of this Agreement, and none of the terms or conditions of Genzymes
or CCCs forms shall be applicable, except for those specifying quantity
ordered, delivery dates, special supply and packing instructions, and invoice
instructions.  3.06Payment Terms.Payment for the Product shall be due
to CCC not later than [                          ]*
days from the date of invoice of Product by CCC. All payments and
communications regarding the Product shall be delivered to CCC at the address
designated in Section 9.06 hereof.  ARTICLE
IV DELIVERY
AND TITLE  4.01Terms of Delivery.    [                              ]*  4.02Manufacture of Product.  A.All Product delivered under this
Agreement shall be manufactured in compliance with the terms and conditions of
the Sublicense Agreement.  B.The Product shall be manufactured in
accordance with all applicable regulatory standards and the Technical Agreement.
CCC shall be responsible for maintaining or causing to be maintained, on behalf
of Genzyme, the retention samples of the Product required by applicable
regulatory standards.  C.CCC shall provide the current
Material Safety Data Sheet (MSDS) to Genzyme for all Product delivered
hereunder.  D.CCC will maintain, and will cause
any Affiliate to maintain, complete and accurate records relating to the
Product and the manufacture, packaging and testing thereof for the period
required by applicable regulatory standards. Without limiting the generality of
the foregoing, CCC shall or shall cause any Affiliate to:  1)perform quality assurance and
control tests on each lot of Product manufactured before delivery and shall
prepare and deliver to Genzyme a written report of the results of such tests,
with each report setting forth for each lot delivered the items tested, specifications
and results in a Certificate  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


of Analysis containing the types
of information required by applicable regulatory standards, and  2)prepare and maintain for a period of
not less than [                              ]*
and for so long as required under applicable regulatory standards for each lot
of Product manufactured a certificate of manufacturing compliance containing
the types of information required by applicable regulatory standards, which
will certify that the lot of Product was manufactured in accordance with
Specifications and cGMPs.  E.Each party shall promptly advise the
other of any safety or toxicity problem of which either party becomes aware
regarding the Product or intermediates used in the manufacture of the Product.  F.The parties shall make their best
efforts to facilitate the incorporation of process improvements approved by
Genzyme into the Product manufacturing scheme.  4.03Inspection.    Within a
reasonable time of arrival of the Product at Genzymes facility or the facility
of a Contract Manufacturer, as the case may be, the recipient of the Product
shall inspect and test the Product at its cost. If the party testing the Product
finds that the Product does not conform to the Specifications, Genzyme shall
within [                              ]*
after the date of such arrival, give CCC written notice of any claim setting
forth the details of such non-conformity and any payment for such
non-conforming Product shall be delayed until conforming Product has been
accepted. CCC shall replace, at its expense, any non-conforming Product within [                              ]*
after CCC receives the above mentioned written notice. This procedure shall
continue until such time as the recipient of the Product shall determine that
the Product conforms to the Specifications. Disputes between the parties as to
whether all or any part of a shipment rejected conforms to the Product
Specifications shall be resolved by a mutually acceptable third-party testing
laboratory.  4.04Plant Visits.    CCC shall,
and shall cause any Affiliate to permit representatives of Genzyme and / or its
Collaborators, to visit the facilities where the Product is manufactured for
the purpose of reviewing the manufacture and testing of the Product and related
batch records and of conducting compliance audits associated with cGMPs and
other regulatory requirements. Genzyme agrees to give CCC and any Affiliate, as
the case may be reasonable notice of any proposed visit to a Product facility
by a Genzyme representative or a Collaborator representative. Any such visits
shall be during normal business hours on work days and be subject to a standard
confidentiality agreement. In addition, CCC shall, and shall cause any
Affiliate to, permit governmental inspectors acting pursuant to statutory
authority to inspect the facilities where the Product is being manufactured,
and to review required documentation. CCC shall notify Genzyme in advance of
any planned visit by a governmental inspector and shall promptly notify Genzyme
following an unscheduled visit by a governmental inspector; provided such
visits are related to the manufacture of Product.  4.05Audit Rights.    CCC agrees
to provide Genzyme with such financial information as Genzyme may reasonably
request in order that Genzyme may verify that any revisions to the Base Price
permitted under Section 3.02 and Schedule 3.01 hereof have been accurately
calculated.  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


ARTICLE
V WARRANTIES,
INDEMNITIES AND INSURANCE  5.01Warranties.  A.CCC warrants that  1)Product delivered pursuant to this
Agreement (whether manufactured by CCC or another CCC Affiliate) shall (i)
conform with the Specifications, (ii) be manufactured in accordance with
applicable regulatory standards, (iii) be conveyed with good title, free from
any lawful security interests, lien or encumbrance, and (iv) if applicable
shall not be adulterated or misbranded within the meaning of the Federal Food,
Drug and Cosmetic Act for manufacturers of active pharmaceuticals ingredients;
provided, however, that CCC shall not be liable for misbranding or adulteration
which is due to any labelling, instructions or packaging provided to CCC by
Genzyme; and,  2)the facility used to manufacture the
Product is in substantial compliance with all applicable regulatory
requirements and there are no pending or uncorrected citations or adverse
conditions affecting the manufacture of Product noted in any inspection of the
facility.  CCC MAKES NO OTHER WARRANTIES,
EXPRESS OR IMPLIED, WITH RESPECT TO THE PRODUCT. ALL OTHER WARRANTIES, EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF
MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE HEREBY DISCLAIMED BY
CCC.  B.Genzyme warrants that it is
authorized to license the Patent Rights to CCC and Karlskoga and other CCC
Affiliates and that the Contract Manufacturers identified to CCC are authorized
and accepted by Nittobo.  C.It is understood and agreed that CCC
has no control over the ultimate use of the Product or use of products that
include or were manufactured with the Product, and CCC shall have no liability
in connection with any such use except as may be set forth below.  5.02Specifications.Genzyme shall deliver to CCC written
notice of any required changes to the Specifications, and CCC will use its best
efforts to accommodate such Specification changes. If any specification change
requested affects CCCs costs of producing the Product, the parties will
negotiate, in good faith, any increases to the pricing set forth in Sections
3.01 and 3.02 hereof.  5.03[                              ]*  A.Genzyme.   [                              ]*  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


B.CCC.[                              ]*  5.04[                              ]*  5.05Patent.  [                              ]*  5.06[                              ]*
Procedures.   [                              ]*  5.07.Minimum Insurance Coverage Limits:Without limiting the scope of its
aforementioned defense, hold harmless and indemnity duties, each partyshall maintain at
its sole cost and expense the following insurance; provided that the parties
may self insure all or any  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


portion of such insurance. The insurance required
hereunder should include at least the following terms and conditions:  A.Policies and Limits. [                              ]*  B.CGL Features:  Said commercial general
liability insurance shall provide primary level coverage for bodily injury, personal
injury, advertising injury, death or property damage (or loss of use thereof)
occurring on, in or about any of the parties premises and/or arising out of
the parties work, which insurance shall be a primary policy. Coverage shall
be afforded with endorsements where necessary to cover risks for
premises-operations, completed operations-products, independent contractors,
and any other activity contemplated by the work.  C.Additional Insured Requirements:  Except
for any portion of the insurance that is self-insured, each party will cause
the other to be named as an additional insured on each of the aforementioned
policies by specific endorsement (except Workers Compensation) unless the
insurer so designates the other party in writing under a blanket coverage
provision. A partys additional insured status shall be applicable as to any
occurrence, accident or condition allegedly arising from the work of the other
party (including any of its employees, agents or contractors).  D.Certificates of Insurance:  Before
commencing the work, each party shall furnish the other a true copy of a
certificate of coverage issued by the responsible insurance carrier or the
party referencing this Agreement, designating the other party as an additional
insured.  E.Cancellation of Insurance: 
Before cancelling or replacing any insurance required under this
Agreement, each party shall give the other at least thirty (30) days written  *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


notice, but only if such
replacement coverage diminishes the scope of the existing coverage. If a party
receives actual or constructive notice that insurance required under this
Agreement is to be terminated by an insurer, than that party shall give the
other party notice of such termination as soon as is commercially reasonable
after such party receives such notice, but in no case, more than two (2)
business days after receiving such notice.  F.Occurrence v. Claims-Made. Provided such coverage is
reasonably commercially available, all
coverages required under this Agreement will be provided upon an occurrence
basis. When only claims-made coverage is available, each party will use
commerically reasonable efforts to either renew and maintain such coverages or
provide an extended reporting endorsement (tail coverage), provided such
coverage is reasonably commercially available.  G.Carrier Rating. Except in the case of self-insurance, all
insurance required under this Agreement shall be placed with an insurer that
has an A.M. Best rating of A-(X) or better.  ARTICLE
VI CONFIDENTIALITY  6.01Confidential Information.Each Party shall maintain as confidential and
shall not disclose to a third party, copy, nor use for purposes other than the
performance of this Agreement, any information which relates to another Partys
or its Affiliates business affairs, financial data, pricing, customer lists,
projects, economic information, systems, plans, procedures, operations,
techniques, technology, patent applications, trade secrets, know-how,
inventions, technical data or specifications, testing methods, research and
development activities, clinical studies (including, without limitation,
information related to the participants of such studies), marketing strategies,
the terms of this Agreement or other confidential or proprietary information
(hereinafter Confidential Information), and each agrees to protect that
Confidential Information with the same degree of care it exercises to protect
its own Confidential Information (but in no event less than a reasonable
standard of care) and to prevent the unauthorized, negligent, or inadvertent
use, disclosure, or publication thereof. The Parties agree that all
Confidential Information relating to Genzyme rights or property described in
Section 7.01 below shall be Genzyme Confidential Information. Each Party may
disclose Confidential Information of another Party only to its own employees,
consultants or advisors having a need to know for the purposes of this Agreement
(which may include, without limitation, temporary and contract employees,
attorneys, technical experts and accountants), provided always that such
employees, consultants and advisors have signed a non-disclosure agreement with
similar and sufficient clauses protecting the disclosure of confidential
information as contained herein or are otherwise bound by such a duty of
confidentiality.  6.02Exceptions. The obligations set forth in
Section 6.01 hereof shall not apply to any Confidential Information which the
receiving Party (in each instance a Receiving Party) can demonstrate: (i) is
or becomes a matter of public knowledge through no fault of the Receiving
Party; (ii) was rightfully in the Receiving Partys possession in a complete
and tangible form before it was received from the disclosing Party (in each
instance, a Disclosing Party), (iii) is furnished to the Receiving Party on a
non-confidential basis from a third party, provided that such third party is
not bound by an obligation of confidentiality to the Disclosing Party with
respect to such Confidential Information; (iv) is independently developed by
the Receiving Party prior to receipt of


the Confidential Information; or (v) is
required to be disclosed to comply with applicable laws or regulations, or with
a valid order of a court or other governmental body of the United States or any
political subdivisions thereof, but only to the extent and for the purposes of
such required disclosure and provided that (a) the Disclosing Party is promptly
notified by the Receiving Party in order to provide the Disclosing Party an
opportunity to seek a protective order, and (b) the Receiving Party takes all
reasonable actions to obtain confidential treatment for such information and,
if possible, to minimize the extent of such disclosure.  6.03Publicity.Except as may be required by
applicable laws and regulations or a court of competent jurisdiction, as
required to meet credit or other financing arrangements, or as required or
appropriate in the reasonable judgment of either party to satisfy the
disclosure requirements of any applicable securities law or regulation, neither
party shall make any public release or other disclosure with respect to this
Agreement or the terms hereof without the prior consent of the other party.  ARTICLE
VII RIGHTS
TO PRODUCT  7.01Ownership.Any and all improvements,
discoveries and/or inventions, whether or not patentable, which may be made or
conceived by CCC or any of the other CCC Affiliates manufacturing Product
during the Initial Term or any Renewal Term of this Agreement and which is
based on the Patent Rights, the Product or products using the Product, shall be
the sole and exclusive property of Genzyme. CCC shall provide and shall cause
any such CCC Affiliate to provide, full disclosure to Genzyme of all such
improvements, discoveries, and/or inventions described above, and shall execute
or cause to be executed any and all applications, assignments, or other
instruments which Genzyme shall deem necessary or useful in order to apply for
and obtain Letters Patent of the United States and all foreign countries for
discoveries and improvements believed to be inventions, and shall assign and
conveyor caused to be assigned and conveyed to Genzyme sole and exclusive
right, title, and interest in and to the discoveries and improvements and to
all patent applications and patents thereon. Genzyme will bear the cost of
preparation of all such patent applications. Notwithstanding the above, Genzyme
grants CCC a limited, perpetual, royalty-free, world-wide license for any
improvements, inventions or discoveries (whether or not patentable) conceived
by CCC during the Initial Term or any Renewal Term related to, or useful in
connection with the Product manufacturing process (i) for CCCs use in the
manufacture of the Product and (ii) for CCCs use in connection with the
manufacture of another product that is not a polyallylamine-based
pharmaceutical product and does not compete with the End Products.  ARTICLE
VIII TERMINATION
FOR CAUSE  8.01 Early Termination.This Agreement may be terminated by
either party as follows:  A.By a party immediately upon written
notice by another party that it has filed or has had filed against it a
petition under the Bankruptcy Act, makes an assignment for the benefits of
creditors, has a receiver appointed for it or any of its assets.  B.By a party if another party fails to
perform or otherwise breaches any of its material obligations hereunder, by
giving notice of its intent to terminate and stating the grounds therefore. The
party receiving such notice shall have ninety (90) days from receipt thereof if
such breach or failure involves a non-monetary obligation and


fifteen (15) days if the breach
or failure is regarding a monetary obligation, to cure the failure or breach,
at which time this Agreement shall terminate if such failure or breach has not
been cured. In no event, however, shall such notice of termination be deemed to
waive any rights to damages or any other remedy which the party giving notice
of breach may have as a consequence of such failure or breach.  8.02Effect of Termination.Termination of this Agreement, for
whatever reason, shall not affect the obligations of specified in Section 8.02
or Articles V, VI, VII and IX hereunder.  ARTICLE IX GENERAL PROVISIONS  9.01Force Majeure.Any delay in the performance of any of the
duties or obligations of either party hereto (except the payment of money)
caused by an event outside the affected partys reasonable control shall not be
considered a breach of this Agreement and the time required for performance
shall be extended for a period equal to the period of such delay. Such events
shall include without limitation any delay of FDA approval for products
incorporating Product; government action or regulation, acts of God; acts of a
public enemy; insurrections; riots; injunctions; embargoes; fires; explosions;
floods; or other unforeseeable causes beyond the reasonable control and without
the fault or negligence of the party so affected. The party so affected shall
give prompt notice to the other party of such cause, and shall take whatever
reasonable steps are appropriate in that partys discretion to relieve the
effect of such cause as rapidly as possible. Notwithstanding the foregoing or
anything else in this Agreement to the contrary, should the force majeure event
result in inability of a party to fully perform hereunder for a period of more
than nine (9) months, the other party shall have the right to immediately
terminate this Agreement.  9.02Assignment.No party shall assign this Agreement
or any part thereof without the prior written consent of the other parties;
provided however, a party, without such consent, may assign or sell the same in
connection with the transfer, license or sale of all or substantially all its
entire business to which this Agreement pertains, in the event of its merger or
consolidation with another company or in the event of the transfer or sale to a
wholly-owned subsidiary.  9.03Successors In Interest.This Agreement shall be binding upon
and inure to the benefit of the parties hereto, their subsidiaries, affiliates,
successors and permitted assigns. Assignment to an Affiliate or subsidiary
shall not release the party making such assignment from responsibility for its
obligations under this Agreement.  9.04Entire Agreement.This Agreement and schedules and
exhibits thereto and the Technical Agreement, together shall constitute the
entire agreement between the parties hereto and shall supersede any other
agreements, whether oral or written, express or implied, as they pertain to the
Product. This Agreement may not be changed or modified except by written
instrument signed by both parties.  9.05Relationship.The relationship created by this
Agreement shall be strictly that of the buyer and seller. No party is hereby
constituted an employee, an agent or legal representative of the other party
for any purpose whatsoever, and is granted no right or authority hereunder to
assume or create any obligation, express or implied, or to make any
representation, warranties or guarantees, except as are expressly granted or
made in this Agreement.


9.06Notice.Any notice required hereunder may be served by
either party on the other by personal delivery, or by sending same, post-prepaid,
by registered or by certified mail, or sent by facsimile to the respective
partys address set forth below:  CCC:
  Cambrex Charles City, Inc.1205 11th StreetCharles City, Iowa 50616-3466Attention: Site Director(fax 641-228-4152)with a copy to:
  Cambrex CorporationOne Meadowlands PlazaEast Rutherford, NJ 07073Attention: General Counsel(fax 201-804-9852)Genzyme:
  Genzyme Corporation500 Kendall StreetCambridge, Massachusetts 02142Attention: Jim Shuman(fax                               )with a copy to:
  Legal departmentMetro West Place15 Pleasant Street ConnectorFramingham, MA 01701  or to such other address as one
party may notify the other as provided herein.  9.07Waiver.      A waiver by
any party for a breach of any of the terms of this Agreement by any other party
shall not be deemed a waiver of any subsequent breach of the terms of this
Agreement.  9.08Governing Law.      This
Agreement is to be governed by and construed in accordance with the laws of the
State of New York without reference to Choice of Law rules.  9.09Severability.If any provision of this Agreement
or the application of any of such provision to any person or circumstance shall
be held invalid, illegal or unenforceable in any respect by a court of
competent jurisdiction, such invalidity, illegality or unenforceability shall
not affect any other provisions thereof.  9.10Dispute Resolution.Any controversy or claim arising out
of or relating to this Agreement, or the breach thereof shall be settled by
arbitration in accordance with the Rules of the American Arbitration
Association and judgment upon award rendered by the Arbitrator(s) may be
entered in


any court having jurisdiction
thereof. Written notice of demand for arbitration shall be filed with the other
party to the Agreement and with the American Arbitration Association within a
reasonable time after the dispute has arisen. Any such arbitration shall be
held in Charles City, Iowa if the arbitration is demanded by Genzyme and in
Boston, Massachusetts if CCC demands the arbitration.  9.11Counterparts.This Agreement may be executed in
any number of counterparts, each of which once executed and delivered, shall be
deemed an original, but all of which constitute but one and the same Agreement.
All headings, captions, exhibits, schedules and tables are inserted by
convenience of reference only and shall not affect the meaning or
interpretation of any provision hereof.  IN
WITNESS WHEREOF, the parties by there authorized representatives have executed this
Agreement as of the date first above written.  Cambrex Charles City, Inc.  /s/ James A. MackBy: James A. MackTitle: President, CEO,
  ChairmanDate: 2-28-06Genzyme Corporation/s/ Michael S. WyzgaBy: Michael S. WyzgaTitle: CFODate: 2-4-06


Schedule 3.01  Price  [                              ]*       *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


Schedule 3.01a  [                              ]*       *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


Exhibit A
Specifications  [                              ]*       *Confidential information omitted and filed
separately with the Securities and Exchange Commission.


EXHIBIT B  TECHNICAL AGREEMENT  [                              ]*      *Confidential information omitted and filed
separately with the Securities and Exchange Commission.