### Page **1** of **59 UNITED STA** **TES ENVIRONMENTA L PROTECTION A** **GENCY**

**WA SHINGTON, D.C. 20460**  **OFFICE OF CHEMICAL SAFETY**  **AND POLLUTION PREVENTION** 



### Date : December 1 8 , 201 5 **Subject: Fluopyram**  **.** Occupational and Residential Exposure Assessment for New Use s

on artichoke (globe), Brassica (cole) leafy vegetables, Brassica (cole) leafy vegetables head and stem subgroup, bulb vegetables, canola, carrot, cereal grains (except rice), citrus, corn (inc luding field, sweet, popcorn, and field corn grown for seed) cotton, cucurbit vegetables, fruiting vegetables, ginseng, grapes and small vines fruits (except fuzzy kiwifruit), herbs and spices (except black pepper), hops, leafy

vegetables, legume vegetables (including so ybean), peanut, pome fruits, potato and other root, tuberous and corm vegetables, small berries (caneberries and bushberries), stone fruit, strawberry and other low growing berries, sugar beet, sunflower subgroup, tree nuts ; use as a seed tre atment to peanuts ; turf grass (g olf c ourses, s od f arms, s ports f

ields, residential, i ndustrial, municipal, c ommercial, and other turf grass areas ), ornamentals ( in r esidential and c ommercial settings), and Christmas trees

. **PC Code:** 080302 **DP Barcode:** D 4 26622 **Decision No.:** 4 9 2321 **File Symbols and Registration No.**  **:** 432
- RLGI ; 432
- RLGT ; 432
- RLGA ; 432
- RLGL ; 432
- RLUG; 264
- 1078; 264
- 1084; 264
- 1085; 264
- 1090; 264
- 1091 **Petition No.:** 4F8284 **Regulatory Action:** Section 3 **Risk Assessment Type:** Occupational/Residential Exposure Assessment **Case No.:** NA **T XR No.:**  NA **CAS No.:** 658066
- 35
- 4 **MRID No.:** NA **40 CFR:** §180. 661 

### From: Barry

O’Keefe, Senior Biologist Risk Assessment Branch III Health Effects Division (7509P) **Through:** Christine Olinger, Branch Chief

Risk Assessment Branch III Health Effects Division (7509P) and Matthew L loyd, CIH , ExpoSAC Reviewer Cassi Walls, Ph.D. , ExpoSAC Reviewer Exposure Science Advisory Committee (ExpoSAC) / HED

### Page **2** of **59**

**To:** Barry

O’Keefe , Risk Assessor Risk Assessment Branch III Health Effects Division (750 9 P) and Tamue Gibson , Risk Management Team #20 Fungicide Herbicide Branch Registration Division (7505P) **Introduction** The Health Effects Division (HED) of the Office of Pesticide Programs (OPP) is charged with estimating the risk to human health from exposure to pesticides. The Registration Division (RD) of OPP has requested that HED evaluate the hazard and exposure data and conduct occupational and residential exposure assessments, as needed, to estimate the risk to human health that will result from the proposed uses of fluop yram ; the other active ingredients in the combination products have been addressed in separate a ssessments
. This memorandum serves as HED’s assessment of the occupational and residential exposure and risk from the se proposed uses . It is HED policy

to use the best available data to assess exposure. Several sources of generic data were used in thi s assessment as surrogate data in the absence of chemical

- specific data, including Pesticide Handlers Exposure Database Version 1.1 (PHED 1.1) ; the Agricultural Handler Exposure Task Force (AHETF) database; the Outdoor Residential Exposure Task Force (ORET F) database ; ExpoSAC Policy 14 , 15, and 15.1 (SOPs for Seed Treatment), The Reviewer’s Aid to Calculating Occupational Exposure from Activities Related to Agricultural Seed Treatment, the Agricultural Reentry Task Force (ARTF) database ; and the Residential SOPs (turf, gardens and trees)

. Some of these data are proprietary , and subject to the data protection provisions of the Federal Insecticide, Fungicide, and Rodenticide Act ( FIFRA). **Note:** This memorandum was reviewed by the Exposure Science Advisory Committee (ExpoSAC) on August 27 , 201 5
.

### Page **3** of **59 Table of Contents**  1.0 Executive Summary

................................ ................................ ................................ ............. 4 2.0 Risk Assessment Conclusions and Recommendations

................................ ........................ 7 2.1 Summary

of Risk Estimates

................................ ................................ ............................. 7 2.2 Data Deficiencies and Requirements

................................ ................................ ............... 7 2.3 Label Recommendations

................................ ................................ ................................ .. 7 3.0 Hazard Characterization

................................ ................................ ................................ ....... 7 4. 0 Use Profile

................................ ................................ ................................ ......................... 10 5.0 Residential Exposure and Risk Estimates

................................ ................................ .......... 28 5.1 Residential Handler Exposure/Risk Estimates

................................ ............................... 28 5.2 Residential Post

- application Exposure/Risk Estimates for Proposed Uses

................... 30 5.3 Combined Residential Risk Estimates (Multiple Exposure Scenarios)

......................... 32 5.4 Residential Risk Estimates for Use in Aggregate Assessment

................................ ...... 32 5.5 Spray

Drift

................................ ................................ ................................ ...................... 33 5.6 Residential By stander Post

- Application Inhalation Exposure

................................ ....... 33 6.0 Occupational Exposure and Risk Estimates

................................ ................................ ...... 34 6.1 Occupational Handler Exposure/Risk Estimates

................................ ............................ 34 6.2 Occupational Post

- application Exposure/Risk Estimates

................................ .............. 43 6.2.1 Occupational Post

- application Inhalation Exposure/Risk Estimates

...................... 44 6.2.2 Occupational Post

- application Dermal Exposure/Risk Estimates

.......................... 44 Appendix A. Summary

of Occupational and Residential Non
- cancer Algorithms

..................... 51

### Page **4** of **59**

**1.0 Executive Summary**  The active ingredient, f

luopy ram ( N
- [2
- [3
- chloro

- 5
- (trifluoromethyl )

- 2
- py ridinyl]ethyl]

- 2
- (trifluorometh yl )benzamide) is a py ridyl eth yl amide SDH (succinate

- dehydrogenase

- inhibitor, complex II) fungicide with broad spectrum of activity against fungal diseases in a wide range of crops . Use Profile The registrant, Baye r CropScience , is requesting num erous new uses on agricultural field crops and crop groups be added to the Luna ® 

### Privilege label (4.16 lb ai/gal) [ EPA Reg. No. 264
- 1078] that contains the sole active ingredient (ai) fluop yr am . Additionally , Bayer CropScience is requesting to add numerou s agricultural field crops and crop groups to the following multi

- active ingredient labels : 1) Propulse TM 

### (1.67 lb ai/gal) [EPA Reg. No. 264

- 1084] which contains fluopy ram and prothioconazole ; 2) Luna® 

### Tranquility (1.04 lb ai/gal) [EPA Reg. No. 264

- 1085] which contains fluop yram and pyrimethanil ; 3) Luna® 

### Sensation (2.1 lb ai/gal) [EPA Reg. No. 264
- 1090] which contains fluopy ram and trifloxy strobin ; and 4 ) Luna ® 

### Experience (1.67 lb ai/gal) [EPA Reg. No. 264

- 1091] which contains fluopy ram and tebuconazole. In addition, Bayer CropScience is requesting a new seed treatment use o n peanut seeds to be added to the Luna ® 

### Privilege label (4.16 lb ai/gal) [ EPA Reg. No. 264
- 1078]
. Baye r CropScience, is also requesting new non - food uses of fluop yram on several newl y proposed labels, including turf grass (g olf c ourses, s od f arms, s ports f

ields, residential, i ndustrial, municipal, c ommercial, and other turf grass areas ), ornamentals ( in r esidential and c ommercial l andscapes, i nteriorscapes, f ield grown and c ontainer o rnamentals, in nurseries, and greenhouses, l athhouses, s hadehouses, c ontainers and o ther enclosed s tructures ), fruit and nut trees (including citrus, grapes, pome fruits, stone fruits, and tree nuts), or namental sunflower, and Christmas trees. The proposed labels are as follows : 1) Fluopy ram 500 SC (4.16 lb ai/gal) [EPA File Sy mbol 432
- RL GI ] which contains fluopy ram ; 2) FLU+TFS SC 500 (2.1 lb ai/gal) [EPA File Sy mbol 432
- RL GT] which contains fluop yram and triflox ys trobin; 3) FLU+TFS SC 32.5 (0.10 4 lb ai/gal) [EPA File S ymbol 432
- RL GA] which contains fluopy ram and trifloxystrobin ; 4) FLU+TFS SC 25 (0.104 lb ai/gal) [EPA File S ymbol 432
- RL GL] which contains fluopy ram and trifloxystrobin ; and 5) 13ESP715 3.3 SC ( 3.34 lb ai/gal) [EPA File S ymbol 432
- RLU G] which contains fluopy

ram . Most of the proposed label s require occupational handlers to wear the following personal protective equipment (PPE): long sleeved shirts, long pants, shoes, socks, and chemical resistant gloves. However, the FLU+TFS SC 32.5 and FLU+TFS SC 25 labels do not require the use of gloves. Additionall y, for the Luna® 

### Privilege label requires water proof gloves for seed treatment activities and no gloves for baggers and bag sewers. On all registered and proposed labels the restricted entry interval (REI) is 12 hours. Fluopy ram is currentl y registered on a vari ety of agricultural food crops , including apple, cherry (sweet and tart), cotton, dried beans, peanut, potato , strawberry , sugar beets, tree nuts,

### Page **5** of **59**

watermelon, viniferous variety grapes , and for seed treatment to cotton and soy bean

. There are no existing residential uses of fluop yram. Exposure Profile There is a potential for short

- and intermediate

- term occupational dermal and inhalation exposure t o fluopy ram during handling tasks (m ixing, loading, and application) and during post

application activities . L ong - term occupational exposure is not expected for the proposed use patterns associated with fluopy ram . There is a potential for residential sho rt - term dermal and inhalation exposure to fluopy ram to adults during handling tasks. During residential post application activities there is a potential for short

- term dermal exposure to adults , youths, and children and incidental oral exposure to children 1 to <2 years old

. Hazard Concerns There have been no changes in the hazard characterization, toxicity endpoints, or points of departure (PODs) since the last risk assessment for fluopy ram. The toxicity

database is considered complete for risk assessment. The liver was the target organ across species and exposure duration s . Treatment
- related thyroid effects were also observed at dose levels cau sing adverse liver perturbations in rats and mice. Decreased body weight was a common clinical finding throughout the toxicology database. Liver tumors were observed in female rats and thy roid tumors were observed in male mice in chronic feeding studies. Short

- and intermediate

- term dermal endpoints were chosen from a dermal toxicity study in rats in which increased prothrombin time and altered cholesterol levels were seen at the limit dose (NOAEL = 300 mg/kg/day). Short

- and intermediate

- term inhalation and short

- term incidental oral risks are based on clinical chemistry and kidney

effects in the parental generation observed at the LOAEL of 82.8 mg/kg/day (NOAEL of 14
. 5 mg/kg/day) from a 2
- generation reproduction study in rats. The subchronic inhalation study data requirement was waived b y the Hazard and Science Policy Council (HASPOC , K. Rury , 1/30/13, TXR No. 0056523). Since the dermal and inhalation endpoints are not based on developmental effects, the average body weight of an adult ( 8 0 kg) was used in the exposure assessment s. S ince the toxicological effects for dermal and inhalation routes are not similar, the risk estimate s from both routes are not combined together

. Also, s ince the toxicological effects for dermal and in cidental oral routes are not similar, the risk estimate s from both routes are not combined together

. HED recommends that the Food Quality Protection Act (FQPA) safety factor be reduced to 1x because there are no residual uncertainties with regard to pre

- and postnatal susceptibility, the toxicology

database is complete, and there is no evidence of neurotoxicity

. Fluopy ram has low acute toxicity by the oral and dermal routes of exposure (Toxicity Category III) and also b y the inhalation route of exposure (Toxicity Cate gory IV). It is not a dermal or eye irritant and is not a dermal sensitizer. The cancer classification is “not like ly to be carcinogenic to humans. ” There is no mutagenic concern for fluop yr am.

### Page **6** of **59**

Occupational Exposure No chemical

- specific handler expo sure data were submitted in support of th e s e Section 3 registration s . To assess handler exposures for regulatory actions when chemical

- specific monitoring data are not available, HED used the most scientifically

- reliable surrogate data currentl y available from various sources such as the PHED and the AHETF

. Some of this data, such as the industry

task force data, is compensatory , subject to the data protection provisions of FIFRA. For occupational handlers for agricultural crops, turf , and Christmas trees, all short

- and intermediate

- term risk estimate s resulted in margins of exposure (MOEs) ≥100, and therefore, do not exceed HED’s level of concern at any l evel of protection . For dermal exposures at baseline personal protective equipment (PPE) , MOEs range from 410 to 1,500,000. For dermal exposures with gloves, MOEs range from 2,400 to 1,100,000. For inhalation exposures, MOEs range from 7,400 to 5,400,000. For the seed treatment use on peanut seed s, risk estimates for dermal and inhalation short

- term occupational handler exposures all resulted in MOE s ≥100, and therefore, do not exceed HED’s level of concern, with MOEs ranging from 1,4 0 0 to 9,2 00 for dermal exposures and from 1,7 0 0 t o 1 7 , 000 for inhalation exposures. Short

- and intermediate

- term d ermal post

- application exposures and risks to occupational workers were estimated using standard values established by HED , since no chemical

- specific data were submitted. For all occupational post

- application scenarios the dermal MOEs , at day zero following application, do not exceed HED’s level of concern (MOEs ≥100) , with dermal MOEs ranging from 270 to 23,000
. Additionally, several post

- application worker scenarios involved with the mechanical harvesting of cotton were assessed. The dermal exposures to these harvesters of cotton resulted in risk estimate MOEs ranging from 3,100,000 to 17,000,000, which also do not exceed HED’s level of concern (MOEs ≥100). Based on the Agency' s current practices, a quantitative occupational post

- application inhalation exposure assessment was not performed for fluop yram at this time. If new policies or procedures are put into place, the Agency may revisit the need for a quantitative occupational post

application inhalation exposure assessment for fluopy ram . Restricted Entry

Interval: The 12

- hour REI that appears on the registered and proposed label s is adequate to protect for worker exposure to fluopy ram . Residential Exposure All residential handler risk estimates are not of concern to HED (all MOEs ≥100), with MOEs ranging from 8,900 to 190,000 for dermal exposures and 260,000 for inhalation exposures. For treated lawns and turf , all residential post

- application risk estimate s are not of concern to HED (all MOEs ≥100), with dermal post

- application MOEs for all life stages rang ing from 1,000 to 97,000 and incidental oral post - application MOEs for children 1 to <2 ye ars old rang ing from 2,400 to 1,100,000. For treated gardens, ornamental trees and shrubs, and fruit trees, the dermal post - application MOEs for all life stages rang e from 2,100 to 33,000 and are not of concern to HED (MOEs ≥100).

### Page **7** of **59**

Human Studies Review This risk assessment relies in part on data from studies in which adult human subjects were intentionally

exposed to a pesticide or other chemical. These data, which include studies from PHED 1.1; the AHETF database; the ARTF database; the ORETF database , and ExpoSAC Polic ies 14 , 15, and 15.1 (SOPs for Seed Treatment), and The Reviewer’s Aid to Calculating Occupational Exposure from Activities Related to Agricultural Seed Treatment are (1) subject to ethics review pursuant to 40 CFR 26, (2) have received that review, and (3) are compliant with applicable ethics requirements. For certain studies, the ethics review may have included review by the Human Studies Review Board. Descriptions of data sources, as well as guidance on their use, can be found at the Agency website 1



### . **2.0 Risk Assessment Conclusions and R**  **ecommendations 2.1**  **Summary of Risk Estimates** There are no occupational or residential risk estimates of concern assoc iated with the proposed use s of fluo py

ram . **2. 2**  **Data Deficiencies and Requirements** There are no data deficiencies or requirements miss ing from the fluopy ram database at this time. **2. 3**  **Label Re**  **commendations** Some of the proposed products for fluop yr am are intended for use b y residential applicators on home lawns or residential areas , but require certain clothing and/or PPE to be worn. Generally , the Agency

does not consider PPE and clothing requirements to be enforceable on consumer lawn products. If products containing fluop yr am are meant to be marketed towards and applied by residential handlers on residential turf, ornamentals, frui t trees, or gardens , HED recommends that the label requirements for clothing and/or PPE be reevaluated or separate consumer

- specific labels be developed. **3 .0**  **Hazard Characterization**  Acute Toxicity The acute toxicity

for fluopy

ram is summarized in Table 3. 1
. Fluop yr am has low acute toxicity by the oral and dermal routes of exposure (Toxicity Category III) and b y the inhalation route of exposure (Toxicity

Category IV). It is not a dermal or eye irritant and is not a dermal sensitizer. **T able**  **3. 1.**  **Acute Toxicity Profile of**  **Fluopyram Technical**  **.**

1 http://www.epa.gov/pesticides/science/handler

- exposure - data.html and http://www.epa.gov/pesticides/science/post

- app - exposure - data.html

### Page **8** of **59**

Guideline No. Study T ype MRID(s) Results Toxicity Category 870.1100 Ac ute Oral 47372430 LD50 > 2000 mg/kg in females III
870.1200 Ac ute Dermal 47372432 LD50 > 2000 mg/kg in males &, females III
870.1300 Ac ute Inhalation (4 hr) 47372434 LC50 > 5.112 mg/L in males & females IV
870.2400 Primary Eye Irritation 47372436 No positive scores at 24 hr; not irritating IV 870.2500 Primary Skin Irritation 47723701 Not irritating IV 870.2600 Dermal Sensitization 47372440 Not sensitizing N/A 870.2600 Dermal Sensitization 47753403 Not sensitizing N/A 

### Toxicological PODs Used for Risk Assessment Short

- and intermediate

- term dermal endpoints were chosen from a dermal toxicity study in rats in which increased prothrombin time and altered cholesterol levels were seen at the limit dose (NOAEL = 300 mg/kg/day). Short

- and intermediate

- term inhalation and short

- term incidental oral risks are based on clinical chemistry and kidney

effects in the parental generation observed at the LOAEL of 82.8 mg/kg/day (NOAEL of 14
. 5 mg/kg/day) from a 2
- generation reproduction study in rats. The subchronic inhalation study data requirement was waived b y the HASPOC (K. Rury, 1/30/13, TXR No. 0056523). Since no inhalation absorption data are available, toxicity by the inhalation route is considered to be equivalent to the estimated toxicity by the oral route of exposure. Since the dermal and inhalation endpoints are not based on developmental effects, t he average body weight of an adult (80 kg) was used in the exposure assessment s. Further, s ince the toxicological effects for dermal and inhalation routes are no t similar, the risk estimate s from both routes are not combined together

. For small children (1 to <2 years old), the risk estimates from the incidental oral and dermal routes should not be combined. The common effects seen in the dermal tox study (use d for establish dermal endpoint) and the 2

- generation reproduction study (used to establish the incidental oral endpoint) appeared to be increases in liver weights and hepatocellular hy pertrophy , but these effects are adaptive effects. For the dermal toxi city study , the other endpoints at the LOAEL included increased prothrombin time (which is hematological effect). In contrast, the other endpoints for establishing the LOAEL were a host of effects including decreases in body weights with decreases in sple en and thy mus weights and slight delay in preputial separation in the offsprings. Therefore, the adverse effects at LOAELfor establishing the tox endpoints in these two studies are different.

### Page **9** of **59**

HED recommends that the Food Quality Protection Act (FQPA) sa fety factor be reduced to 1x because there are no residual uncertainties with regard to pre

- and postnatal susceptibility, the toxicology

database is complete, and there is no evidence of neurotoxicity

. There is no mutagenic concern for fluop yram . HED cl assified fluop yr am as “Not Likely to be Carcinogenic to Humans” at doses that do not induce cellular proliferation in the liver or thyroid glands ( TXR# 0056961, CARC Report, 05/0 8 /2014 )

. This classification was based on convincing evidence that non - genotoxic modes of action for liver tumors in rats and thy roid tumors in mice have been established and that the carcinogenic effects have been demonstrated as a result of a mode of action dependent on activation of the CAR/PXR receptors. HED has determined that quantification of risk is not required (TXR# 0056961, CARC Report, 05/08/2014)

. A summary

of the toxicological doses and endpoints for occupational and residential human health risk assessment is provided in Table 3. 2
. **Table 3.2. Summ ary of**  **Toxicological Doses and Endpoints for Fluopyram for Use in Occupational**  **and Residential**  **Hum an Health Risk Assessments.**  Exposure/ Scenario Point of

Departure Uncertainty

Factors Level of Concern

for Risk Assessment Study and Toxicological Effects

Incidental Oral Short

- Term

(1

- 30 days) and Intermediate

- Term (1

- 6 months) NOAEL=

14.5 mg/kg/day UF A= 10 X

UF H=10 X FQPA SF=1 X Residential LOC

for MOE = 100 2
- G eneration r eproduction study in rats

The LOAEL of 82.8 mg/kg/day is based clinical chemistry changes and increased kidney weight in parents, and decreased body weight and body weight gain with decreases in spleen and thymus weights in offspring

. Dermal Short

- Term (1

- 30 days) and Intermediate

- Term (1

- 6 months) NOAEL=

300 mg/kg/day UF A= 10 X

UF H=10 X FQPA SF=1 X Residential and

Occupational LOC for MOE = 100 A 28
- day dermal study in rats The LOAEL of 1000 mg/kg/day is based on increased cholesterol (F), increased prothrombin time (M).

Inhalation Short

Term (1

- 30 days) and Intermediate

Term (1

- 6 mo nths) NOAEL=

1 4 .5 mg/kg/day UF A= 10 X

UF H=10 X FQPA SF=1 X Residential and

Occupational LOC for MOE = 100 2
- G eneration r eproduction study in rats

The LOAEL of 82.8 mg/kg/day is based clinical chemistry changes and increased kidney weight in parents, and decreased body weight and body weight gain with decreases in spleen and thymus weights in offspring

. Cancer (oral, dermal, inhalation) **Classification:** The CARC classified fluopyram as “Not Likely to be Carcinogenic to Humans”

at doses that do not induce cellular proliferation in the liver or thyroid glands

. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). MOE = margin of exp osure. LOC = level of concern.

### Page **10** of **59**

**4 .0**  **Use Profile** Fluopy ram is currentl y registered on a vari ety of agricultural food crops , including apple, cherry (sw eet and tart), cotton, dried beans, peanut, potato , strawberry , sugar beets, tree nuts, watermelon, viniferous variety grapes , and for seed treatment to cotton and soy bean

. There are currentl y no existing residential uses of fluop yram . The registrant, Baye r CropScience, is requesting the addition of new uses of fluopy ram on registered liquid formulation product labels, as follows: 1) The Luna ® 

### Privilege label (4.16 lb ai/gal) [EPA Reg. No. 264

- 1078] contains only the active ingredient fluop yr am. New uses are proposed on artichoke (globe), Brassica (cole) leafy

vegetables, bulb vegetables, canola, carrot, cereal grains (except rice), citrus, cotton, cucurbit vegetables, fruiting vegetables, ginseng, grapes and small vines fruits (except fuzzy

kiwifruit), herbs and spices (except black pepper), hops, leafy vegetables, legume vegetables (including so ybean), peanut, pome fruits, potato and other root, tuberous and corm vegetables, small berries (caneberries and bushberries), stone fruit, strawberry

and oth er low growing berries (except cranberries) , sugar beet, sunflower subgroup, and tree nuts. Additionally , the Luna Privilege label is also proposed for use as a seed treatment to peanuts. 2) The Propulse TM 

### label (1.67 lb ai/gal) [EPA Reg. No. 264

- 1084] c ontains the active ingredients fluopy

ram and prothioconazole. New uses are proposed on barley , buckwheat, bushberry

subgroup, canola, corn, crambe, cucurbit vegetables, field mustard, Indian rapeseed, low growing berries (except strawberries and cranberri es ), millet (pearl and proso), oats, rapeseed, rye, soy bean, triticale, and wheat (spring, durum, and winter). 3) The Luna ® 

### Tranquility label (1.04 lb ai/gal) [EPA Reg. No. 264

- 1085] contains the active ingredients fluop yram and p yrimethanil. New uses are proposed on bulb vegetables, ginseng, lemons, pome fruit, tuberous and corm vegetables, small berries (caneberries and bushberries), stone fruit (except cherries), strawberries and other low

growing berries (except cranberries) , and tomato. 4) The Luna ® 

### Sensation label (2.1 lb ai/gal) [EPA Reg. No. 264

- 1090] contains the active ingredients fluopy

ram and trifloxystrobin. New uses are proposed on artichoke (globe), Brassica (head and stem subgroup), Brassica (leafy greens subgroup), carrot, citrus, cucurbit vegetables, fruiting vegetables, ginseng, grapes and small vines fruits (except fuzzy kiwifruit), herbs and spices (except black pepper), hops, leafy vegetables (leafy greens subgroup), leafy

vegetables (l eaf petioles subgroup), pome fruits, potato and other root, tuberous and corm vegetables, so ybean, stone fruit, strawberry and other low growing berries (except cranberries) , and wheat. 5) The Luna ® 

### Experience label (1.67 lb ai/gal) [EPA Reg. No. 264

- 1091] contains the active ingredients fluop yram and tebuconazole. New uses are proposed on barley , bean (fresh and dry , except succulent shelled), bulb vegetable, corn (sweet corn, field corn, field cor n grown for seed, and popcorn), cotton, cucurbit vegetables, fruiting vegetables,

### Page **11** of **59**

grapes and small vines fruits (except fuzzy kiwifruit), hops, leafy Brassica greens, okra , pome fruits, soy

bean, stone fruit, sunflower, and wheat. Baye r CropScience, is als o requesting the registration of several new end

- use products containing the following new non - food uses of fluopy ram : turf grass (g olf c ourses, s od f arms, s ports f ields, residential, i ndustrial, municipal, c ommercial, and other turf grass areas ), ornament als ( in r esidential and c ommercial l andscapes, i nteriorscapes, f ield grown and c ontainer o rnamentals, in nurseries, and greenhouses, l athhouses, s hadehouses, c ontainers and o ther enclosed s tructures ), and Christmas trees. These new end

- use product labels also include proposed uses on citrus, grapes and small vine fruits, pome fruits, stone fruits, sunflower, and tree nuts . All of these uses can be used by occupational, as well as residential , handler s . The proposed end

- use product labels are as fo llows : 1) Fluopy ram 500 SC (4.16 lb ai/gal) [EPA File Sy mbol 432
- RL GI ] which contains the active ingredient fluopy ram ; 2) FLU+TFS SC 500 (2.1 lb ai/gal) [EPA File S ymbol 432
- RL GT] which contains the active ingredients fluopy ram and trifloxystrobin; 3) FLU+ TFS SC 32.5 (0.104 lb ai/gal) [EPA File S ymbol 432
- RL GA] which contains the active ingredients fluopy ram and trifloxystrobin ; 4) FLU+TFS SC 25 (0.104 lb ai/gal) [EPA File S ymbol 432
- RL GL] which contains the active ingredients fluopy ram and trifloxystrobin ; and 5) 13ESP715 3.3 SC ( 3.34 lb ai/gal) [EPA File S ymbol 432
- RLU G] which contains the active ingredient fluopy ram . The proposed labels require occupational handlers to wear the following attire and PPE: long sleeved shirts, long pants, shoes, socks, and chemical resistant gloves. However, the FLU+TFS SC 32.5 and FLU+TFS SC 25 labels do not require the use of gloves. Additionally , for seed treatment of peanuts, the Luna ® 

### Privilege label requires water proof gloves for seed treatment activities and no gloves for baggers and bag sewers. On all registered and proposed labels the proposed REI for new uses is 12 hours. The proposed uses and application rates are described in detail in Table 4 .1.

### Page **12** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  **Agricultural Use Sites**
Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Artichok e (globe)**  0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 7 to 10 days. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.0660 to 0.125 (4.0 to 7.6 fl oz/A)

Gr ound, aerial or chemigation Luna Sensation

(2.1 lb ai/gal) [264

- 1090] **Brassica Leafy Vegetables Head and Stem Subgroup:**  Broccoli, Chinese broccoli (Gai Lon), Brussels sprouts, Cabbage, Chinese cabbage (Napa), Chinese cabbage (Bok choy), Chinese mustard cabbage (Gai choy), Cauliflower, Cavalo broccolo, Kohlrabbi. I ncluding all cultivars and/or hybrids of these. 0.0660 to 0 .125 (4.0 to 7.6 fl oz/A) NS 0.446 0 Retreatment interval of 7 to 10 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Brassica (cole) Leafy Vegetables**  : Broccoli, Broccoli raab (Rapini), Brussels sprouts, Cabbage, Cauliflower, Cavalo broccoli, Chinese broccoli (Gai Lon), Chinese cabbage (Bok choy), Chinese cabbage (Napa), Chinese mustard cabbage (Gai choy), Collards, Kale, Mizuna, Mustard greens, Mustard spinach, Rape greens, and Turnip greens. I ncluding all cultivars and/or hybrids of these. 0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 5 to 10 days.

Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Brassica Leafy Vegetables Leafy Greens Subgroup**  : Broccoli raab (Rapini), Chinese cabbage, Collards, Kale, Mizuna, Mustard greens, Mustard spinach, Rape greens, and Turnip greens. I

ncluding all cultivars and/or hybrids of these. 0.0660 to 0.125 (4.0 to 7.6 fl oz/A) NS 0.446 0 Retreatment interval of 7 to 14 days. Luna Experience (1.67 lb ai/gal) [264
- 1091] **Leafy Brassica**  **Greens (Crop Subgroup 5B)** : Broccoli raab (rapini), Chinese cabbage (bok choy), Collards, Kale, Mizuma, Mustard greens, Mustard spinach, Rape greens, and

Turnip greens, 0.0783 to 0.112 (6.0 to 8.6 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Bulb Vegetables** : Chive fresh leaves, Chive fresh leaves (Chinese), Daylily bulb, Elegans hosta, Fritillaria (bulb and leaves), Garlic bulb, Garli c bulb (Great headed and Serpent), Kurrant, Leek, Leek (Lady’s and Wild), Lily bulb, Onion (Beltsville bunching, Bulb, Chinese bulb, Fresh, Green, Macrostem, Pearl, Potato bulb, Tree tops, and Welsh), Shallot (bulb and fresh leaves). I ncluding all cultivar s and/or hybrids of these. 0.13 to 0.222 (4.0 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 5 to 7 days.

Luna Experience (1.67 lb ai/gal) [264
- 1091] **Bulb Vegetables** : Chive fresh leaves, Chive fresh leaves (Chinese), Daylily bulb, Elegans hosta, Fritillaria (bulb and leaves), Garlic bulb, Garlic bulb (Great headed and Serpent), Kurrant, Leek, Leek (Lady’s and Wild), Lily bulb, Onion (Beltsville bunching, Bulb, Chinese bulb, Fresh, Green, 0.104 to 0.167 (8.0 to 12.8 fl oz/A) NS 0.446 7 Retreatment interval of 10 to 14 days.

### Page **13** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  Macrostem, Pearl, Potato bulb, Tree tops, and Welsh), Shallot

(bulb and fresh leaves). Luna Tranquility (1.04 lb ai/gal) [264
- 1085] **Bulb Vegetables**  : Dry Bulb Onion, Eschalots, Green Onion,

Garlic, Leeks, Japanese Bunching Onion, Scallions, Shallot,

and Spring Onion. 0.130 to 0.219 (16.0 to 27.0 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 14 days.
Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Canola subgroup** : Borage, Crambe, Cuphea, Echium, Flax seed, Gold of pleasure, Hare’ ear mustard, Lesquerella, Lunaria, Meadowfoam, Milkweed, Mustard seed, Oil radish, Poppy seed, Rapeseed, Sesame, and Sweet rocket. I nc luding cultivars, varieties, and/or hybrids of these. 0.222 (6.84 fl oz/A) NS 0.446 14 Retreatment interval of 12 to 14 days.
Gr ound, aerial or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Canola Rapeseed, Indian Rapeseed, Field Mustard, Crambe**  0.177 (13.6 fl oz/A) NS 0.446 36 Retreatment interval of 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Carrot** 0.156 to 0.222 (4.8 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 5 to 7 days. Tops or greens from this crop may be utilized for food or feed. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.0660 to 0.125 (4.0 to 7.6 fl oz/A) 7 Retreatment interval of 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Cereal Grains (except Rice)** : Barley, Buckwheat, Corn (Sweet Corn, Field Corn, Field Corn Grown for Seed, and Popcorn), Millet, (Pearl and Proso), Oats, Rye, Sorghum, Sudan Grass, Teosinte, Triticale, and Wheat. 0.222 (6.84 fl oz/A) NS 0.446 14 Retreatment interval of 14 days. Do not allow livestock to graze treated area for 14 days and do harvest for food or feed within 14 days of application.

Gr ound, aerial or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Barley** 0.177 (13.6 fl oz/A) NS 0.446 32 Retreatment interval of 14 days.

Luna Experience (1.67 lb ai/gal) [264
- 1091] **Barley** 0.112 (8.6 fl oz/A) NS 0.446 30 Retreatment interval not specified. Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application. Gr ound or aerial Propulse

(1.67 lb ai/gal) [264
- 1084] **Buck wheat, Millet (Pearl and Proso), Oats, Rye**  0.177 (13.6 fl oz/A) NS 0.446 30 Gr ound, aerial or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Wheat** 0.177 (13.6 fl oz/A) NS 0.446 30 Retreatment interval of 14 days.

### Page **14** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations** 

Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Wheat** 0.112 (6.84 fl oz/A) NS 0.446 35 Retreatment interval of 14 to 21 days. If two applications or 0.224 lb ai/A/yr are applied, do not allow livestock to graze within the treated area and do not harvest the treated crop for forage or hay. If one application or 0.112 lb ai/A/yr are applied, do not allow livestock to graze within the treated area within 30 days after application, and do not harvest the treated crop for forag e within 30 days after application or for hay within 45 days after application.
Luna Experience (1.67 lb ai/gal) [264
- 1091] **Wheat** 0.112 (8.6 fl oz/A) NS 0.446 30 Retreatment interval not specified. Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed for 14 days of application.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Forage, Fodder or Straw from Cereal Grains:** Barley,

Buckwheat, Corn (Sweet Corn, Field Corn, Field Corn Grown for Seed, and Popcorn), Millet, (Pearl and Proso), Oats, Rye, Sorghum, Sudan Grass, Teosinte, Triticale, and Wheat. 0.222 (6.84 fl oz/A) NS 0.446 14 Retreatment interval of 14 days. Do not allow livestock to graze treated area for 14 days and do harvest for food or feed within 14 days of application.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Citrus** : Australian desert lime, Australian finger

- lime, Brown River finger lime, Calamondin, Citron, Citrus hybrids, Grapefruit, Japanese summer grapefruit, Kumquat, Lemon, Li me, Mediterranean mandarin, Mount white lime, New Guinea wild lime, Orange (sour and sweet), Pummelo, Russell River lime, Satsuma mandarin, Sweet lim e, Tachibana orange, Tahiti lime, Tangelo, Tangerine (Mandarin), Tangor, Trifoliate orange, Uniq fruit, White sapote (Casimiroa spp.) and cultivars, varieties, and/or

hybrids of these. 0.156 to 0.222 (4.8 to 6.84 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 21 days. Minimum 30 day interval between soil applications.

### Page **15** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations** 

Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Citrus** : Calamondin, Citrus Citron, Citrus hybrids ( Citrus spp., includes Chironja, Tangelo and Tangor), Grapefruit, Grapefruit, Kumquat, Lemon, Lime, Mandarin (Tangerine), Orange (Sweet and Sour), Pummelo, Tangelo, Satsuma Mandarin, White Sapote (Casimiroa spp.), and other cultivars

and/or hybrids of these. 0.12 5 (7.6 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 21 days. Fluopyram 500 SC (4.16 lb ai/gal) [264
- RLGI]

**C itrus**  0.156 to 0.221 lb ai/100 gal/A 4.8 to 6.8 fl oz/100 gal/A

NS 0.446 lb ai/A 13.7 fl oz/A

7 Retreatment interval of 7 to 21 days. Retreatment interval for nematode control is 30 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.125 lb ai/100 gal/A 7.6 fl oz/100 gal/A 0.44 6 lb ai/A 27. 3 fl oz/A FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.125 lb ai/100 gal/A 154 fl oz/100 gal/A 0.445 lb ai/A 548 fl oz/A 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.157 to 0.446 lb ai/100 gal/A 6.0 to 17.1 fl oz/100 gal/A 0.446 lb ai/A 17.1 fl oz/A Gr ound, aerial or chemigation Luna Tranquility

(1.04 lb ai/gal) [264
- 1085] **Lem on**  0.219 (27.0 fl oz/A) NS 0.446 7 Retreatment interval not specified. The use of adjuvants is prohibited.

Gr ound, aerial or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Corn (including Field Corn, Sweet Corn, Popcorn, and Field Corn grown for seed)**  0.177 (13.6 fl oz/A) NS 0.446 14 0 Retreatment interval of 7 to 14 days. For field corn, field corn grown for seed, and popcorn, do not apply within 14 days of harvest for grain or fodder. For sweet corn, do not apply within 14 days of harvest for fodder. Sweet corn ears and forage may be harvested the same day of application.

Luna Experience (1.67 lb ai/gal) [264
- 1091] **Corn (Sweet Corn, Field Corn, Field Corn Grown for Seed, and Popcorn)**  0.167 (12.8 fl oz/A) NS 0.446 See Li mits Retreatment interval of 14

days. For field corn, field corn grown for seed, and popcorn, may be applied up to 21 days before harvest of forage, and 36 days before the harvest of grain or fodder. For sweet corn, may be applied within 7 days before

### Page **16** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  harvest of ears or forage, and 49 days before the harvest of fodder. Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application.
Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1 078] **Cotton Subgroup (20C): Includes cultivars, varieties and other hybrids of these.**  0.156 to 0.222 (4.8 to 6.84 fl oz/A) NS 0.446 30 Retreatment interval not specified. Luna Experience (1.67 lb ai/gal) [264
- 1091] **Cotton** 0.222 (17.0 fl oz/A) NS 0.446 30 Retreatment interval of 7 to 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Cucurbit Vegetables:** Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin (edible, includes Hyotan, Cucuzza, Hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (hybrids and/or cultivars of Cucumis melo including True cantaloupe, Cantaloupe, Casaba, Crenshaw melon, Golden Pershaw melon, Honeydew melon, Honey balls, Mango melon, Persian melon, Pineapple melon, Santa Claus melon, Snake melon), Pumpkin, Squash (includes Summ er Squash types such as: Crookneck squash, Scallop squash, Straight neck squash, Vegetable marrow, Zucchini, and Winter squash types such as Acorn squash, Butternut squash, Calabaza, Hubbard squash, Spaghetti squash), and Watermelon (includes hybrids and/or varieties of Citrullus lanatus ). 0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 5 to 14 days; except for soil applications with minimum 5 day interval between soil applications.

Gr ound or chemigation Propulse

(1.67 lb ai/gal) [2 64
- 1084] **Cucurbit Vegetables:** Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin, Edible gourd (includes hyotan, cucuzza, hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (includes cantaloupe), Pumpkin, Squash (summer and winter, includes Butternut squash, Calabaza, Hubbard squash, Acorn squash, Spaghetti squash), and Watermelon

. 0.177 (13 .6 fl oz/A) NS 0.446 7 Retreatment interval of 5 to 10 days. Only 1 soil application allow; up to two foliar applications allowed.

Gr ound, aerial or chemigation Luna Sensation

(2.1 lb ai/gal) [264

- 1090] **Cucurbit Vegetables:** Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin (edible, includes Hyotan, Cucuzza, Hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (hybrids and/or cultivars of Cucumis melo including True 0.0660 to 0.125 (4.0 to 7.6 fl oz/A) 4 0.446 0 Retreatment interval of 7 to 14 days; except for soil applications with minimum 7 day interval between soil applications.

### Page **17** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  cantaloupe, Cantaloupe, Casaba, Crenshaw melon, Golden Pershaw melon, Honeydew melon, Honey balls, Mango melon, Persian melon, Pineapple melon, Santa Claus melon, Snake melon), Pumpkin, Squash (includes Summ er Squash types such as: Crookneck squash, Scallop squash, Straight neck squash, Vegetable marrow, Zucchini, and Winter squash types such as Acorn squash, Butternut squash, Calabaza, Hubbard squash, Spaghetti squash), and Watermelon (includes hybrids and/or varieties of Citrullus lanatus ).

Luna Experience (1.67 lb ai/gal) [264
- 1091] **Cucurbit Vegetables:** Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin (edible, includes Hyotan, Cucuzza, Hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (hybrids and/or cultivars of Cucumis melo including True cantaloupe, Cantaloupe, Casaba, Crenshaw melon, Golden Pershaw melon, Honeydew melon, Honey balls, Mango melon, Persian melon, Pineapple melon, Santa Claus melon, Snake melon), Pumpkin, Squash (includes Summer Squash types such as: Crookneck squash, Scallop squash, Straight neck squash, Vegetable marrow, Zucchini, and Winter squash types such as Acorn squash, Butternut squash, Calabaza, Hubbard squash, Spaghetti squash), and Watermelon (i ncludes hybrids and/or varieties of Citrullus lanatus ). 0.0783 to 0.222 (6.0 to 17.0 fl oz/A) NS 0.446 7 Retreatment interval of 10 to 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Fruiting Vegetables:** African eggplant, Bush Tomato,

Cocona, Currant tomato, Eggplant, Garden huckleberry, Goji berry, Martynia, Naranjilla, Okra, Pea eggplant, Pepino, Pepper ( Capsicum spp., including Bell, Chili, Cooking, Pimento and Sweet), Roselle, Scarlet eggplant, Sunber ry, Tomatillo, Tomato, Tree tomato, and cultivars, varieties,

and/or hybrids of these. 0.117 to 0.222 (3.60 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 7 days.

Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Fruiting Vegetables:** Eggplant, Groundcherry, Okra, Pepinos, Pepper ( Capsicum spp., including Bell, Chili, Cooking, Pimento and Sweet), Tomatillo, and Tomato. 0.0825 to 0.125 (5.0 to 7.6 fl oz/A) 5 0.446 3 Retreatment interval of 7 to 14 days.
Luna Experience (1.67 lb ai/gal) [264
- 1091] **Fruiting Vegetables:** African eggplant, Bush Tomato,

Cocona, Currant tomato, Eggplant, Garden huckleberry, Goji berry, Martynia, Naranjilla, Pea eggplant, Pepino, Non Bell Pepper, Roselle, Scarlet eggplant, Sunberry, Tomatillo, Tomato, Tree tomato, and cultivars, varieties, and/or hybrids of these. 0.0783 to 0.222 (6.0 to 17.0 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 14 days.

Gr ound, aerial or chemigation Luna Experience

(1.67 lb ai/gal) [264
- 1091] **Ok ra**  0.167 (12.8 fl oz/A) NS 0.446 3 Retreatment interval of 14 days.

### Page **18** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations** 

Gr ound, aerial or chemigation Luna Tranquility

(1.04 lb ai/gal) [264
- 1085] **Tom ato**  0.0910 (11.2 fl oz/A NS 0.446 1 Retreatment interval of 7 to 14 days. For greenhouse uses apply only in well

- ventilated plastic tunnel houses or glass houses. Ventilate for at least 2 hours after application.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Ginseng** 0.222 (6.84 fl oz/A) NS 0.446 7 Retreatment interval of 5 to 7 days. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.125 (7.6 fl oz/A) NS 0.446 7 Retreatment interval of 14 days. Luna Tranquility (1.04 lb ai/gal) [264
- 1085] 0.130 to 0.219 (16.0 to 27.0 fl oz/A) NS 0.446 30 Retreatment interval of 7 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Grapes and Small Vine Fruits (except fuzzy k**  **iwifruit)** : Amur River grape, Gooseberry, Grape , Kiwifruit, Hardy, Maypop, Schisandra berry, and cultivars, varieties, and/or

hybrids of these varieties. 0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 7 Retreatment interval of 12 to 21 days. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.0660 to 0.125 (4.0 to 7.6 fl oz/A) 6 0.446 14 Retreatment interval of 12 to 21 days. Luna Experience (1.67 lb ai/gal) [264
- 1091] 0.0783 to 0.112 (6.0 to 8.6 fl oz/A) NS 0.446 14 Retreatment interval of 12 to 21 days. Luna Tranquility (1.04 lb ai/gal) [264
- 1085] 0.130 to 0.219 (16.0 to 27.0 fl oz/A) NS 0.446 7 Retreatment interval of 12 to 14 days.

Gr ound, Drench or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI]
**Grapes and Small Vine Fruits**  0. 104 to 0.221 lb ai/100 gal/A 3.2 to 6.8 fl oz/100 gal/A NS 0.446 lb ai/A 13.7 fl oz/A 7 Retreatment interval of 12 to 21 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.0 656 to 0.125 lb ai/100 gal/A 4 .0 to 7.6 fl oz/100 gal/A 6 0.44 6 lb ai/A 27. 3 fl oz/A 14 Retreatment interval of 12 to 21 days. FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.0821 to 0.125 lb ai/100 gal/A 101 to 154 fl oz/100 gal/A 6 0.445 lb ai/A 548 fl oz/A 14 Retreatment interval of 12 to 21 days. 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0. 112 to 0.223 lb ai/100 gal/A 4.28 to 8.56 fl oz/100 gal/A NS 0.446 lb ai/A 17.1 fl oz/A 7 Retreatment interval of 12 to 21 days. Gr ound, aerial Luna Privilege **Herbs and Spices (except black pepper)**  : Allspice, 0.13 to 0.222 NS 0.446 0 Retreatment interval of 7

### Page **19** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  or chemigation (4.16 lb ai/gal)

[264
- 1078] Angelica, Anise (anise seed), Anise (star), Annatto, (seed),

Balm (lemon balm), Basil (fresh and dried), Borage, Bumet, Camomile, Caper buds, Caraway, Caraway (black), Cardamom, Cassia (bark and buds), Catnip, Celery seed, Chervil (dried), Chinese chive, Chive, Cinnamon, Clary, Clove (buds), Coriander (cilantro or Chinese parsley leaves), Corinader seed (cilantro seed), Costmary, Cilantro (leaf and seed), Cumin, Curry l eaf, Dill (seed), Dillweed, Fennel [common and Florence (seed)], Fenugreek, Grains of paradise, Horehound, Hyssop, Juniper berry, Lavender, Lemongrass, Lovage (leaf and seed), Mace, Marigold, Mustard (seed), Nasturtium, Nutmeg, Parsley (dried), Pennyroyal, Poppy (seed), Rosemary, Rue, Saffron, Sage, Savory (summer and winter), Sweet bay (bay leaf), Tansy, Tarragon, Thyme, Vanilla, Wintergreen, Woodruff, and

Wormwood. (4.0 to 6.84 fl oz/A) to 10 days.

Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.0660 to 0.125 (4.0 to 7.6 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 10 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078]

**Hops** 0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 7 Retreatment interval of 14 days.

NS Luna Sensation

(2.1 lb ai/gal) [264

- 1090] 0.0495 to 0.125 (3.0 to 7.6 fl oz/A) 4 0.446 14 Retreatment interval of 14 days. Do not replant areas within 30 days of the last application. Do not graze cover crops within the treated area. Do not harvest cover crops within the area treated for silage and hay. Do not apply using aerial application. Do not apply using low volume applicators. Do not apply through any type of irrigation system. Do not apply on hops in Cali fornia. Gr ound, aerial or chemigation Luna Experience

(1.67 lb ai/gal) [264
- 1091] 0.104 to 0.222 (8.0 to 17.0 fl oz/A) NS 0.446 14 Retreatment interval of 14 days.
Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Leafy Vegetables (except Watercress)**  : Amaranth (Leafy amaranth, Chinese spinach, Tampala), Arugula (Roquette), Cardoon, Celery, Celtuce, Chervil, Chinese celery, Chrysanthemum, (Edible

- leaved and Garland), Cilantro, Corn salad, Cress (Garden), Cress (Upland, Yellow rocket , Winter 0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 0 3 Retreatment interval of 7 to 10 days. For lettuce greenhouse uses the PHI is 3 days.

### Page **20** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  cress), Dandelion, Dock (Sorrel), Endive (Escarole), Florence fennel (Sweet anise, Sweet fennel, Finocchio), Lettuce (Head and Leaf), Orach, Parsley, Purslane (Garden and Winter), Radicchio (Red Chicory), Rhubarb, Spinach [including New Zealand an d vine (Malabar spinach, Indian spinach)], and

Swiss chard.

Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Leafy Greens Vegetables**  **(except Watercress)** : Amaranth (Leafy amaranth, Chinese spinach, Tampala), Arugula (Roquette), Chervil, Chrysanthemum, (Edible

- leaved and Garland), Cilantro, Corn salad, Cress (Garden), Cress (Upland, Yellow rocket, Winter cress), Dandelion, Dock (Sorrel), Endive (Escarole), Lettuce (Head and Leaf), Orach, Parsley, Purslane (Garden and Winter), Radicchio (Red Chicory), Rhubarb, and Spinach [including New Zealand and

vine (Mal abar spinach, I

ndian spinach)]. 0.125 (7.6 fl oz/A) NS 0.446 0 Retreatment interval of 14 days.

Gr ound, aerial or chemigation Luna Sensation

(2.1 lb ai/gal) [264

- 1090] **Leafy Petiole Vegetables:** Cardon, Celery, Chinese celery, Florence fennel (including Sweet anise, Sweet fennel, Finocchio), Rhubarb, Swiss chard. 0.0660 to 0.0957 (4.0 to 5.8 fl oz/A) NS 0.446 7 Retreatment interval of 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Legume Vegetables (including Soybean)** : Edible Podded

Legume Vegetables: Bean ( Phaseolus spp. ) ( includes Runner Bean, Snap Bean, Wax Bean); Bean (Vigna spp. ) (includes Asparagus Bean, Chinese Longbean, Moth Bean, Yardlong Bean); Jackbean; Pea (Pisum spp.) (includes Dwarf Pea, Edible

- pod Pea, Snow Pea, Sugar Snap Pea); Pigeon Pea; Soybean (immature se ed); Sword Bean. Succulent Shelled Pea and Bean : Bean (Phaseolus spp.) (includes Lima Bean (green); Broad Bean (succulent); Bean (Vigna spp.) ( except Cowpea, Southpea); Pea (Pisum spp.) (includes English Pea, Garden Pea, Green Pea); Pigeon Pea. Dried Sh elled Pea and Bean. Dried Cultivars of Bean (Lupinus spp.) (includes Grain Lupin, Sweet Lupin, White Lupin, White Sweet Lupin); (Phaseolus spp.) (includes Field Bean, Kidney Bean, Lime Bean Dry), Navy Bean, Pinto Bean; Tepary Bean; Bean (Vigna spp.) ( incl

udes Adzuki Bean, Blackeyed Pea, Catjang, Moth Bean, Mung Bean, Rice Bean, Southern Pea, Urd Bean; except Cowpea & Crowder Pea); Broad Bean (Dry); Chickpea; Guar; Lablab Bean; and Lentil. 0.156 to 0.222 (4.8 to 6.84 fl oz/A) NS 0.446 0 Do not apply to cult ivars that are to be grazed, cut for forage or hay, or used as livestock feed.

Gr ound, aerial or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Dried Beans:**  Bean ( Lupinus spp., includes Grain lupin, Sweet lupin, White lupin, and White sweet lupin), Bean ( Phaseolus spp., includes Field bean, Kidney bean, Lima bean, Navy bean, Pinto bean, and Tepary bean), Bean (Vigna spp., includes Adzuki bean, Blackeyed pea, Catjang, Crowd er pea, Moth bean, Mung bean, Rice bean, Southern pea, and 0.134 to 0.177 (10.3 to 13.6 fl oz/A) NS 0.446 14 Retreatment interval of 7 to 14 days. Allow 7 days from the last application until cutting or swathing the crop for harvest. Do not feed hay or threshings

### Page **21** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  Urd bean), Broad Bean (dry), Chickpea, Guar, Lablab Bean,

and Lentil. or allow livestock to graze in treated areas.

Gr ound, aerial or chemigation Luna Experience

(1.67 lb ai/gal) [264
- 1091] **Beans (Fresh and**  **Dry , except Succulent Shelled)**  0.104 to 0.167 (8.0 to 12.8 fl oz/A) NS 0.446 14 Retreatment interval of 10 to 14 days. Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application.

Gr ound, aerial or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084]

**Soybean** 0.133 (10.2 fl oz/A) NS 0.446 21 Retreatment interval of 10 to 14 days. Do not allow livestock to graze soybean and do not harvest soybean hay for food or feed. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.125 (7.6 fl oz/A) NS 0.446 21 Retreatment interval of 14 days. Do not allow livestock to graze soybean and do not harvest soybean hay for food or feed. Luna Experience (1.67 lb ai/gal) [264
- 1091] 0.112 (8.6 fl oz/A) NS 0.446 21 Retreatment interval of 10 to 14 days. Do not allow livestock to graze soybean and do not harvest soybean hay for food or feed.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Pom e Fruits**  : Apple , Azarole, Crabapple, Loquat, Mayhaw, Medlar, Pear, Pear (Asian), Quince, Quince (Chinese and Japanese), Tejocote, and cultivars, varieties, and/or hybrids of these. 0.078 to 0.222 (2.4 to 6.84 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 14 days. Luna Experience (1.67 lb ai/gal) [264
- 1091] 0.0652 to 0.130 (5.0 to 10.0 fl oz/A) NS 0.446 75 Retreatment interval of 7 to 14 days. Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Pom e Fruits**  : Apple , Crabapple, Loquat, Mayhaw, Pear, Oriental Pear, Quince. 0.0660 to 0.0957 (4.0 to 5.8 fl oz/A) 4 0.446 14 Retreatment interval of 7 to 14 days. Luna Tranquility (1.04 lb ai/gal) [264
- 1085] 0.0975 to 0.130 (12.0 to 16.0 fl oz/A) NS 0.446 72 Retreatment interval of 7 to 10 days. Gr ound, Drench or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI] **Pom e Fruits**  0.0780 to 0.221 lb ai/100 gal/A 2.4 to 6.8 fl oz/100 gal/A NS 0.446 lb ai/A 13.7 fl oz/A 7 Retreatment interval of 7 to 14 days. FLU+TFS SC 500 0.0656 to 0.0952 lb ai/100 gal/A 4 0.345 lb ai/A 14 Retreatment interval of 7

### Page **22** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  (2.10 lb ai/gal) [264
- RLGT] 4.0 to 5.8 fl oz/100 gal/A 21.0 fl oz/A to 14 days. FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.0650 to 0.0951 lb ai/100 gal/A 80 to117 fl oz/100 gal/A 4 0.345 lb ai/A 425 fl oz/A 14 Retreatment interval of 7 to 14 days. 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.0783 to 0.223 lb ai/100 gal/A 3.0 to 8.56 fl oz/100 gal/A NS 0.446 lb ai/A 17.1 fl oz/A 7 Retreatment interval of 7 to 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Potato and Other Root, Tuberous, and Corm Vegetables**  : Arracacha, Arrowroot, Artichoke (Chinese and Jerusalem), Beet (Garden), Burdock (Edible), Canna (Edible, Queensland arrowroot), Cassava (Bitter & Sweet), Celeriac (Celery root), Chayote (root), Chervil (Turnip - rooted), Chickory, Chufa, Dasheen (Taro), Ginger, Horseradish, Leren, Parsley (Turnip

rooted), Parsnip, Potato , Radish, Oriental radish (Daikon), Rutabaga, Salsify (Black), Salsify (Oyster plant), Salsify (Spanish), Skirret, Sweet potato, Tanier (Cocoyam), Turmeric, Turnip, Yam bean (Jicama, Manoic pea) and Yam (True). 0.13 to 0.222 (4.0 to 6.84 fl oz/A) NS 0.446 7 Retreatment interval of 5 to 7 days. The grazing of livestock in treated areas within 7 days of application is prohibited. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.0825 to 0.0957 (5.0 to 5.8 fl oz/A) 4 0.446 7 Retreatment interval of 14 days.

Luna Tranquility (1.04 lb ai/gal) [264
- 1085] **Potato and Other Root, Tuberous, and Corm Vegetables**  : Arracacha, Arrowroot, Artichoke (Chinese and Jerusalem), Canna (Edible), Cassava (Bitter & Sweet), Chayote (root), Chufa, Dasheen (Taro), Ginger, Leren, Potato , Sweet Potato, Tanier (Cocoyam), Turmeric, Yam bean, and Yam (True). 0.0650 to 0.0910 (8.0 to 11.2 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Sm all Berries (caneberries and bushberries):** 

**Black berry**  Rubus spp. (including Andean blackberry, Artic blackberry, Bingleberry, Black blackberry, Boysenberry, Brombeere, California blackberry, Chesterberry, Cherokee blackberry, Cheyenne blackberry, Common blackberry, Coryberry, Darrowberry, Dewberry, Dirksen thornle ss berry, Evergreen blackberry, Himalayaberry, Hullberry, Lavacaberry, Loganberry, Lowberry, Lucretiaberry, Mammoth blackberry, Marionberry, Mora, Mures deronce, Nectarberry, Northern dewberry, Olallieberry, Oregon evergreen berry, Phenomenalberry, Rangeberry, Ravenberry, Rossberry, Shawnee blackberry, Southern dewberry, Tayberry, Youngberry, Zarzamora, and cultivars, varieties,

and/or hybrids of these. **Raspberry** Rubus spp. (

Rubus occidentalis, Rubus strigosus, Rubus idaeus ) (including Bababery, Black raspb erry, Blackcap, Framboise, Frambueso, Himbeere, Keriberry, Mayberry, Purple raspberry, Red raspberry, Thimblberry, Tulameen, Wild raspberries, Yellow raspberry) and cultivars, 0.156 to 0.222 (4.8 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 7 to 10 days.

### Page **23** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  varieties, and/or hybrids of these. **Bushberry** (including Berry (Aronia), Blueber ry (Highbush and Lowbush), Currant (Buffalo), Guava (Chilean), Currant (Black and Red), Barberry (European), Elderberry, Gooseberry, Cranberry (Highbush), Honeysuckle, Huckleberry, Jostaberry, Juneberry, Currant (Native), Salal, Sea buckthorn, and cultivar s, varieties, and/or hybrids of these.

Gr ound, aerial or chemigation Luna Tranquility

(1.04 lb ai/gal) [264
- 1085] **Sm all Berries (caneberries and bushberries):** 

**Black berry**  Rubus spp. (including Andean blackberry, Artic blackberry, Bingleberry, Black Satin berry, Boysenberry, Brombeere, California blackberry, Chesterberry, Cherokee blackberry, Cheyenne blackberry, Common blackberry, Coryberry, Darrowberry, Dewberry , Dirksen thornless berry, Evergreen blackberry, Himalayaberry, Hullberry, Lavacaberry, Loganberry, Lowberry, Lucretiaberry, Mammoth blackberry, Marionberry, Mora, Mures deronce, Nectarberry, Northern dewberry, Olallieberry, Oregon evergreen berry, Phenomenalberry, Rangeberry, Ravenberry, Rossberry, Shawnee blackberry, Southern dewberry, Tayberry, Youngberry, Zarzamora, and cultivars, varieties,

and/or hybrids of these. **Raspberry** Rubus spp. (

Rubus occidentalis, Rubus strigosus, Rubus idaeus ) (including Baba bery, Black raspberry, Blackcap, Framboise, Frambueso, Himbeere, Keriberry, Mayberry, Purple raspberry, Red raspberry, Thimblberry, Tulameen, Wild raspberries, Yellow raspberry) and cultivars,

varieties, and/or hybrids of these. **Bushberry** (including Berry (A ronia), Blueberry (Highbush and Lowbush), Currant (Buffalo), Guava (Chilean), Currant (Black and Red), Barberry (European), Elderberry, Gooseberry, Cranberry (Highbush), Honeysuckle, Huckleberry, Jostaberry, Juneberry, Currant (Native), Salal, Sea buckth orn, and cultivars, varieties, and/or hybrids of these. 0.111 to 0.219 (13.6 to 27.0 fl oz/A) NS 0.446 0 Retreatment interval of 7 to 14 days.

Gr ound or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Bushberry subgroup:**  Aronia berry, Blueberry (Highbush

and Lowbush), Chilean Guava, Currant (Black, Buffalo, and Red), Highbush Cranberry, Elderberry, European Barberry, Gooseberry, Edible Honeysuckle, Huckleberry, Jostaberry, Juneberry (Saskatoon berry), Ligonberry, Native Currant, Salal, Sea buckthorn, and cultivars, varieties, and/or hybrids of these. 0.177 (13.6 fl oz/A) NS 0.446 7 Retreatment interval of 7 to 10 days.

Gr ound, aerial Luna Privilege **Stone Fruit:** Apricot, Apricot (Japanese), Capulin, Cherry 0.13 to 0.222 NS 0.446 0 Retreatment interval of 5

### Page **24** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  or chemigation (4.16 lb ai/gal)

[264
- 1078] (Black, Nanking, Canada, Sweet, Tart), Jujube (Chinese), Nectarine, Peach, Plum, Plum (American, Beach, Canada, Cherry, Chickasaw, Damson, Japanese, Klamath), Prune, Plumcot, Sloe, and cultivars, varieties, and/ or hybrids of these. (4.0 to 6.84 fl oz/A) to 7 days.

Luna Sensation (2.1 lb ai/gal) [264

- 1090] **Stone Fruit:** Apricot, Cherry (Sweet and Tart) , Nectarine, Peach, Plum (including Chickasaw, Damson, Japanese), Plumcot, and Prune (Fresh and Dried). 0.0825 to 0.125 (5.0 to 7.6 fl oz/A) 4 0.446 1 Retreatment interval of 7 to 14 days. Luna Experience (1.67 lb ai/gal) [264
- 1091] **Stone Fruit:** Apricot, Cherry (Sweet, Tart), Nectarine, Peach,

Plum (all varieties including Chickasaw, Damson, Japanese, and Stanley), Plumcot, and Prune (fresh and dried). 0.0783 to 0.130 (6.0 to 10.0 fl oz/A NS 0.446 0 Retreatment interval of 5 to 7 days.
Luna Tranquility (1.04 lb ai/gal) [264
- 1085] **Stone Fruit:** Apricot, Nectarine, Peach, Plum (all varieties including Chickasaw, Damson, Japanese, and Stanley), Plumcot, and Prune (fresh and dried). 0.0975 to 0.219 (12.0 to 27.0 fl oz/A NS 0.446 2 Retreatment interval of 7 to 14 days. Do not make more than two applications of a group 9 fungicide within 30 days of harvest.

Gr ound, Drench or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI]

**Stone Fruits** 0.130 to 0.221 lb ai/100 gal/A 4.0 to 6.8 fl oz/100 gal/A NS 0.446 lb ai/A 13.7 fl oz/A 0 Retreatment interval of 5 to 7 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.0820 to 0.125 lb ai/100 gal/A 5.0 to 7.6 fl oz/100 gal/A 4 0.251 lb ai/A 15.3 fl oz/A 1 Retreatment interval of 7 to 14 days. FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.0821 to 0.125 lb ai/100 gal/A 101 to 154 fl oz/100 gal/A 4 0.251 lb ai/A 309 fl oz/A 1 Retreatment interval of 7 to 14 days. 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.157 to 0.223 lb ai/100 gal/A 6.0 to 8.56 fl oz/100 gal/A NS 0.446 lb ai/A 17.1 fl oz/ 0 Retreatment interval of 5 to 7 days. Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Strawberry and Other Low**  **- Growing Berries**  **(except Cranberries)**  **:** Bearberry, Bilberry, Blueberry (Low

- bush), Cloudberry, Ligonberry, Muntries, Partridgeberry, and

Strawberry. 0.104 to 0.222 (3.2 to 6.84 fl oz/A) NS 0.446 0 Retreatment interval of 7 days.
Gr ound or chemigation Propulse

(1.67 lb ai/gal) [264
- 1084] **Low Growing Berry subgroup, except Strawberry**  **and Cranberries**  **:** Bearberry, Bilberry, Cloudberry, Muntries, Partridgeberry, and cultivars, varieties, and/or hybrids of these. 0.134 (10.3 fl oz/A) NS 0.446 45 Retreatment interval of 7 to 10 days.

Gr ound, aerial or chemigation Luna Sensation

(2.1 lb ai/gal) [264

- 1090] **Strawberry and Other Low**  **- Growing Berries**  **(except Cranberries)**  **:** Bearberry, Bilberry, Blueberry (Low

- bush), Cloudberry, Ligonberry, Muntries, Partridgeberry, and

Strawberry. 0.0660 to 0.125 (4.0 to 7.6 fl oz/A) NS 0.446 0 Retreatment interval of 7 to 14 days. Luna Tranquility **Strawberry and Other Low**  **- Growing Berries**  **(except** 0.130 to 0.219 NS 0.446 1 Retreatment interval of 7

### Page **25** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations**  (1.04 lb ai/gal) [264
- 1085] **Cranberries) :**  Bearberry, Bilberry, Blueberry (Low

- bush), Cloudberry, Ligonberry, Muntries, Partridgeberry, and

Strawberry. (16.0 to 27.0 fl oz/A) to 14 days.

Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Sugar beet**  0.222 (6.84 fl oz/A) NS 0.446 7 Retreatment interval of 5 to 7 days. Propulse (1.67 lb ai/gal) [264
- 1084] 0.177 (13.6 fl oz/A) NS 0.446 7 Retreatment interval of 14 days. Luna Sensation (2.1 lb ai/gal) [264

- 1090] 0.0924 to 0.125 (5.6 to 7.6 fl oz/A) NS 0.446 21 Retreatment interval of 10 to 14 days. Tops or greens from this crop may be utilized for food or feed. Gr ound, aerial or chemigation Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Sunflower Subgroup:** Calendula, Castor oil plant, Chinese

tallowtree, Euphorbia, Evening primrose, Jojoa, Niger seed, Rose hib, Safflower, Stokes aster, Sunflower, Tallowwood, Tea oil plant, Veronia, and cultivars, varieties and/or hybrids of these. 0.222 (6.84 fl oz/A) NS 0.446 14 Retre atment interval of 14 days.
Gr ound, aerial or chemigation Luna Experience

(1.67 lb ai/gal) [264
- 1091] **Sunflower** 0.117 to 0.167 (9.0 to 12.8 fl oz/A NS 0.446 50 Retreatment interval of 14 days. Gr ound, Drench or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI] **Sunflower** 0.221 lb ai/100 gal/A 6.8 fl oz/100 gal/A NS 0.446 lb ai/A 13.7 fl oz/A 14 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.223 lb ai/100 gal/A 8.56 fl oz/100 gal/A NS 0.446 lb ai/A 17.1 fl oz/ 14

Gr ound or Chemigation FLU+TFS SC 500

(2.10 lb ai/gal) [264
- RLGT] **Tree Nuts** 0.0820 to 0.125 lb ai/100 gal/A 5.0 to 7.6 fl oz/100 gal/A NS 0.251 lb ai/A 15.3 fl oz/A 60 Retreatment interval of 7 to 21 days. FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.0821 to 0.125 lb ai/100 gal/A 101 to 154 fl oz/100 gal/A NS 0.251 lb ai/A 309 fl oz/A 60 **Seed Treatment** Seed treatment with commercial slurry mixture equipment only. Luna Privilege

(4.16 lb ai/gal) [264
- 1078] **Peanut** 0.049725 to 0.124475 lb ai/100 lb seed (1.53 to 3.83 fl oz per 100 lb of peanut seeds) 1 0.446 (from all uses) NA Do not use treated seed for food, feed, or oil purposes. **Non Agricultural Use Sites**

### Page **26** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations** 

Gr ound or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI]

**Turf Grass** : Golf Courses, Sod Farms, Sports Fields, Industrial, Municipal, Commercial, and other Turf G rass areas. 0.0013 to 0.010 1 lb ai/1000 ft2 (0.04 to 0.31 fl oz/1000 ft2 ) (0.0566 to 0.43 9 lb ai/A)

NS 0.3145 fl oz/1000 ft2 13.7 fl oz/A 0.446 lb ai/A

NA Retreatm ent interval of 7 to 28 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.000820 to 0.00984 lb ai/1000 ft2 (0.05 to 0.6 fl oz/1000 ft 2 ) (0.0557 to 0.429 lb ai/A) 0. 6267 fl oz/1000 ft2 2 7.3 fl oz/A 0.446 lb ai/A FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.00121 to 0.0102 lb ai/1000 ft2 (1.5 to 12.6 fl oz/1000 ft 2 ) (0.0531 to 0.446 lb ai/A) 12.6 fl oz/1000 ft2 549 fl oz/A 0.446 lb ai/A FLU+TFS SC 32.5 (0.104 lb ai/gal) [264
- RLGA] 0.00121 to 0.0102 lb ai/1000 ft2 (1.5 to 12.6 fl oz/1000 ft 2 ) (0.0531 to 0.446 lb ai/A) 12.6 fl oz/1000 ft2 549 fl oz/A 0.446 lb ai/A 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.0013 to 0.010 2 lb ai/1000 ft2 (0.05 to 0.39 fl oz/1000 ft2 ) (0.0566 to 0.4 44 lb ai/A) 0.393 fl oz/1000 ft2 17.1 fl oz/A 0.446 lb ai/A

Gr ound Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI]

**Residential Turf Grass**  0.0013 to 0.0 0912 lb ai/1000 ft2 (0.04 to 0. 28 fl oz/1000 ft2 ) (0.0566 to 0. 396 lb ai/A)

NS 0. 2847 fl oz/1000 ft2 1 2.4 fl oz/A 0.4 03 lb ai/A

NA Retreatment interval of 7 to 28 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.000820 to 0.009 19 lb ai/1000 ft2 (0.05 to 0. 5 6 fl oz/1000 ft2 ) (0.0557 to 0.4 00 lb ai/A) 0. 5647 fl oz/1000 ft2 24.6 fl oz/A 0.4 04 lb ai/A FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.00121 to 0.00 926 lb ai/1000 ft2 (1.5 to 1 1.4 fl oz/1000 ft2 ) (0.0531 to 0.4 04 lb ai/A) 11.4 fl oz/1000 ft2 497 fl oz/A2 0.4 04 lb ai/A FLU+TFS SC 32.5 (0.104 lb ai/gal) [264
- RLGA] 0.00121 to 0.00 926 lb ai/1000 ft2 (1.5 to 1 1.4 fl oz/1000 ft2 ) (0.0531 to 0.4 0 4 lb ai/A) 11.4 fl oz/1000 ft2 497 fl oz/A 0.4 0 4 lb ai/A 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.0013 to 0.0 09285 lb ai/1000 ft2 (0.05 to 0.3 558 fl oz/1000 ft2 ) (0.0566 to 0.4 04 lb ai/A) 0.3 558 fl oz/1000 ft2 15.5 fl oz/A 0.4 0 4 lb ai/A

Gr ound , Drench or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI] **Ornamentals:** in Residential and Commercial Landscapes, Interiorscapes, Field Grown and Container Ornamentals, in Nurseries, and Greenhouses, Lathhouses, Shadehouses, Containers and Other Enclosed Structures. 0.221 lb ai/100 gal/A 6.8 fl oz/100 gal/A

NS 13.7 fl oz/A 0. 446 lb ai/A

NA Retreatment interval of 7 to 21 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.0164 to 0.131 lb ai/100 gal/A 1.0 to 8.0 fl oz/100 gal/A 27.3 fl oz/A 0.446 lb ai/A Retreatment interval of 7 to 28 days. FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.0163 to 0.130 lb ai/100 gal/A 20 to 160 fl oz/100 gal/A 0.445 lb ai/A 548 fl oz/A Retreatment interval of 7 to 28 days. 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.223 lb ai/100 gal/A 8.56 fl oz/100 gal/A 0.446 lb ai/A 17.1 fl oz/A Retreatment interval of 7 to 21 days.

### Page **27** of **59 Table**  **4 .1. Summ**  **ary of Proposed Directions for Use of Fluopyram .**  **Application Tim** **ing, Type, and Equip.**  **Form ulation** 

**[EPA Reg. No.] Crops**  **Application Rate (lb ai/A)**  **Max. No.**  **Applic . per**  **Season Max. Seasonal** 

**Applic. Rate (lb**  **ai/A) PHI** 

**(days) Use Directions and** 

**Lim itations** 

Gr ound or Chemigation Fluopyram 500 SC

(4.16 lb ai/gal) [264
- RLGI]

**Christmas Trees** 0.221 lb ai/100 gal/A 6.8 fl oz/100 gal/A

NS 13.7 fl oz/A 0.446 lb ai/A

NA Retreatment interval of 7 to 21 days. FLU+TFS SC 500 (2.10 lb ai/gal) [264
- RLGT] 0.220 lb ai/100 gal/A 13.4 fl oz/100 gal/A 27.1 fl oz/A 0.445 lb ai/A FLU+TFS SC 25 (0.104 lb ai/gal) [264
- RLGL] 0.220 lb ai/100 gal/A 271 fl oz/100 gal/A N S 13ESP715 3.3 SC (3.34 lb ai/gal) [432
- RL UG] 0.223 lb ai/100 gal/A 8.56 fl oz/100 gal/A 0.446 lb ai/A 17.1 fl oz/A

### Page **28** of **59**

**5 .0**  **Residential Exposure and Risk Estimates**  Based on the proposed product labels, several products are intended for use by homeowners, or by occupational handlers in residential settings. Therefore, non

- occupational/residential risk assessments have been completed. **5 .1**  **Residential Handler Exposure/Risk Estimates** HED uses the term “handlers” to describe those individuals who are involved in the pesticide application process. HED believes that there are distinct tasks related to applications and that exposures can vary

depending on the specifics of each task. Residential handlers are addressed somewhat differentl y b y HED as homeowners are assumed to complete all elem ents of an application without use of any protective equipment. The quantitative exposure/risk assessment developed for residential handlers is based on the following residential handler scenarios : 1. Mixing/L oading/Applying liquids for manuall y pressuriz ed handwand for gardens, ornamentals , fruit trees, and turf; 2. Mixing/L oading/Applying liquids for hose

- end sprayers for gardens, ornamentals , fruit trees, and turf; 3. Mixing/L oading/Applying liquids for backpack for gardens, ornamentals , fruit trees, and turf ; and 4. Mixing/L oading/Applying liquids for sprinkler cans for gardens, ornamentals , fruit trees , and turf

. Residential Handler Exposure Data and Assumptions Short

- term dermal and inhalation exposures were assessed for residential handlers. A series of as sumptions and exposure factors served as the basis for completing the residential handler risk assessments. Each assumption and factor is detailed below. Application Rate: For flower gardens, ornamentals, and fruit trees , the proposed maximum single application rate is 0. 223 lb ai/A. Applications to residential turf have a proposed maximum single application rate of 0.446 lb ai/A for occupational handlers and 0.404 lb ai/A for residential handlers. Unit Exposures and Area Treated or Amount Handled: Unit exposure values and estimates for area treated or amount handled were taken from HED’s 2012 Residential SOPs 2



### .

2 Available: http://www.epa.gov/pesticides/science/residential

- exposure - sop.html

### Page **29** of **59**

Exposure Duration: Residential handler exposure is expected to be short

- term in duration. Intermediate

- term exposures are not likel y because of the intermittent nature of applications by homeowners. Residential Handler Exposure and Risk Estimate Equations The algorithms used to estimate exposure and dose for residential handlers can be found in Appendix A and/or the 2012 Residential SOPs 3



### . Summary of Residential Handler Non

- Cancer Exposure and Risk Estimates Dermal and inhalation exposures were not combined , since different endpoints and PODs are used for both routes of exposure. Table 5.1 summarizes the residential handler exposures and risk estimates for fluop yr am. All residential handler risk estimates are not of concern to HED (all MOEs ≥100), with MOEs ranging from 8,900 to 190,000 for dermal exposures and 260,000 for inhalation exposures. **Table 5.1**  **. Residential Handler Shor t**  **- term** **Exposure and Risk Estimates for Fluopyram**  **.**
**Use Site Equipment/** 

**Application Method Application**  **Rate 1**  **A rea** 

**Treated or**  **Am ount**  **Handled Daily**  **2 Exposure** 

**Route Unit** 

**Exposure (m** **g/lb ai) Daily Dose**  **3**

**(m g/k** **g/day) MOE**  **4**

Gardens / Trees Manually

- Pressurized

Handwand 0.00223 lb

ai/gal 5 gal Dermal 63 0.0088 34,000 Inhalation 0.018 0.0000025 5,800,000 Gardens / Trees Manually

- Pressurized

Handwand 0.000005119

lb ai/ft2 1200 ft2 Dermal 63 0.0048 62,000 Inhalation 0.018 0.0000014 10,000,000 Gardens / Trees Hose
- End Sprayer 0.00223 lb ai/gal 11 gal Dermal 58 0.018 17,000 Inhalation 0.0014 0.00000043 34,000,000 Gardens / Trees Hose
- End Sprayer 0.000005119 lb ai/ft2 1200 ft2 Dermal 58 0.0045 67,000 Inhalation 0.0014 0.00000011 130,000,000 Gardens / Trees Backpack 0.00223 lb ai/gal 5 gal Dermal 130 0.018 17,000 Inhalation 0.14 0.000020 740,000 Gardens / Trees Backpack 0.000005119 lb ai/ft2 1200 ft2 Dermal 130 0.010 30,000 Inhalation 0.14 0.000011 1,300,000 Gardens / Trees Sprinkler Can 0.00223 lb ai/gal 5 gal Dermal 58 0.0081 37,000 Inhalation 0.0014 0.00000020 74,000,000 Gardens / Trees Sprinkler Can 0.000005119 lb ai/ft2 1200 ft2 Dermal 58 0.0045 67,000 Inhalation 0.0014 0.00000011 130,000,000 Lawns / Turf Manually

- Pressurized

Handwand 0.00404 lb

ai/gal 5 gal Dermal 63 0.016 19,000 Inhalation 0.018 0.0000045 3,200,000 Lawns / Turf Hose
- End Sprayer 0.404 lb ai/A 0.5 A Dermal 13.4 0.034 8,900 Inhalation 0.022 0.000056 260,000

3 Available: http://www.epa.gov/pesticides/sc ience/residential

- exposure - sop.html

### Page **30** of **59**

**Table 5.1**  **. Residential Handler Shor t**  **- term** **Exposure and Risk Estimates for Fluopyram**  **.**
**Use Site Equipment/** 

**Application Method Application**  **Rate 1**  **A rea** 

**Treated or**  **Am ount**  **Handled Daily**  **2 Exposure** 

**Route Unit** 

**Exposure (m** **g/lb ai) Daily Dose**  **3**

**(m g/k** **g/day) MOE**  **4**

Lawns / Turf Backpack 0.00404 lb ai/gal 5 gal Dermal 130 0.033 9,100 Inhalation 0.14 0.000035 410,000 Lawns / Turf Sprinkler Can 0.000009285 lb ai / ft2 1000 ft2 Dermal 13.4 0.0016 190,000 Inhalation 0.022 0.0000026 5,700,000 1 Maximum Single Application Rate. 2 Units Treated taken from Science Advisory Council for Exposure, Standard Operating Procedure 9.1, Standard Values for Daily Acres Treated in Agriculture, Rev. 25 SEP 2001. 3 Daily Dose = Unit Exposure x Application Rate x Units Treated  Body Weight ( 80 k g). 4 Margin Of Exposure (MOE) = NOAEL (mg/kg/day)  D aily D ose (mg/kg/day); where the NOAEL = 300 mg/kg/day for dermal exposure & 14.5 mg/kg/day for inhalation exposure

. 

### 5 **.2 Residential Post** **- application Exposure/Risk Estimates**  **for Proposed Uses** There is the potential for post

- application exposure to fluopy ram for individuals exposed as a result of being in an environment that has been previously treated with fluop yr am. The quantitative exposure/risk assessment for residential post

- application exposure s includes the following scenarios:

 Adults and children (1 to <2 years old) dermal exposure to treated turf during high contact lawn activities,  Children (1 to <2 years old) incidental oral exposure as a result of contacting treated turf,  Adults and youths (11 to <16 y r old) dermal exposure to treated turf during mowing and golfing activities,  Children (6 to <11 years old) dermal exposure to treated turf during golfing activities, and  Adults and children (6 to <11 years old) dermal exposure to treated gardens. The exposure assessment for dermal exposure to treated gardens is protective of exposure to treated ornamental and fruit trees. The lifestages selected for each post

- application scenario are based on an analy sis provided as an Appendix in the 20 12 Residential SOPs 4 

### . These lifestages are not the onl y lifestages that could be potentially

exposed for these post

- application scenarios; however, the assessment of these lifestages is health protective for the exposures and risk estimates for any other potentially exposed lifestages. Residential Post

- application Exposure Data and Assumptions A series of assumptions and exposure factors served as the basis for completing the residential post - application risk assessment. Each assumption and factor is det ailed in the 2012 Residential

4 Available: http://www.epa.gov/pesticides/science/residential

- exposure - sop.html

### Page **31** of **59**

SOPs 4



### . The algorithms used to estimate exposure and dose for residential post

- application exposures can be found in Appendix A and/or the 2012 Residential SOPs 5



### . TTR data for F

lu o p yram Because turf transferable residue data were not available for fluop yr am , turf residues were estimated using default assumptions. A TTR study is not required for fluopyram at this time. Refer to Section 6.2.2 of this document for a detailed rationale. DFR data for F

luop yram Because dislodgeable foliar residue data were not available for fluop yram , f oliar residues were estimated using default assumptions. A DFR study is not required for fluopy ram at this time. Refer to Section 6.2.2 of this document for a detailed rationale. Exposure s are expected to be short

- term in duration. Short

- term dermal and incidental oral exposure and risk estimates have been assessed. Combining Exposure a nd Risk Estimates HED combines risk values resulting from separate routes of exposure when it is likely they can occur simultaneousl y based on the use pattern and the behavior associated with the exposed population, and if the hazard associated with the po ints of departure is similar across routes. Since dermal and incidental oral exposure routes do not share a common toxicological endpoint for fluop yram , risk estimates have not been combined for those routes. Table s 5 .2 .1 and 5.2.2 summarize the residential post

- application exposure and risk estimates for exposures to treated lawns and turf . The proposed liquid formulation s do not lead to post

application risk estimates of concern. Residential dermal post

- application MOEs for all life stages range from 1 ,00 0 to 97 ,000. Residential incidental oral post - application MOEs for children 1 to <2 ye ars old range from 2, 4 00 to 1,10 0,000. **Table 5. 2.**  **1. Residential Post**  **- Application Derm**  **al Short -**  **Term Exposure and Risk Estim ates from**  **Turf .**  **S cenario**  **Application**

**Rate (lb ai/A)**  **TTR 1** 

**(μg/cm 2**  **) Exposure** 

**Tim e (hr)**  **Population TC**  **(cm 2**  **/hr) Daily Dose**  **2**

**(m g/k** **g/day) MOE**  **3**
Golf Course Turf 0.446 0. 0496 4 Adults 5,300 0.0131 23,000 Youths 11 to <16 yr old 4,400 0.0153 20,000 Children 6 to <11 yr old 2,900 0.0180 17,000 High Contact Activities 0.4 0 4 0.04 49 1.5 Adults 180,000 0.1 52 2 , 0 00 Children 1 to <2 yr old 49,000 0.3 00 1 ,00 0 Mowing Turf 0.4 0 4 0.04 4 9 1 Adults 5,500 0.003 09 97 ,000 Youths 11 to <16 yr old 4,500 0.003 55 85 ,000 1 TTR derived as follows: 0

. 446 lb ai/A x 4.54E+8 μg/lb x 2.47E

- 8 A/cm2 x 0.01 (fraction of transferable ai) = 0. 0496 μg/cm2 or 0
. 404 lb ai/A x 4.54E+8 μg/lb x 2.47E

- 8 A/cm2 x 0.01 (fraction of transferable ai) = 0. 0449 μg/cm2

. 2 Daily Dose = [TTR (μg/cm2 ) x (0.001 mg/μg) x Dermal Transfer Coefficient x Exposure Time ] / [Body weight ( 80 kg for adults, 57 kg for youths 11 to <16 yr, 32 kg for children 6 to <11 yr , and 11 kg for children 1 to <2 yr old)]. 3 MOE = N OAEL/Daily Dose. Short

- Term N OAEL = 300 mg/kg/day. **Table 5.2.2. R** **esidential Post -**  **Application Incidental Oral Exposure to 1 to <2 Year Olds from Turf.** 

5 Available: http://www.epa.gov/pesticides/science/residential

- exposure - sop.html

### Page **32** of **59 Scenario**  **Application Rate (lb ai/A)**  **Daily Dose (m g/kg/day)**  **MOE** Hand

- to - Mouth 0.4 0 4 0.006 15 2, 4 00 Object

- to - Mouth 0.4 0 4 0.0001 87 7 8 ,000 Soil Ingestion 0.4 0 4 0.000 0 1 4 1,10 0,000 1 TTR derived as follows: 0

. 404 lb ai/A x 4.54E+8 μg/lb x 2.47E

- 8 A/cm2 x 0.01 (fraction of transferable ai) = 0. 0449 μg/cm2

. 2 Based on HED’s 201 2 Residential SOPs: Lawns/Turf (http://www.epa.gov/pesticides/science/residential

- exposure - sop.html ). 3 MOE = N OAEL/Daily Dose. Short

- Term N OAEL = 14
. 5 mg/kg/day. 

### Table 5.2 .3 summarize s the residential po st - application exposure and risk estimates for exposures to treated gardens, ornamental trees and shrubs, and fruit trees. The proposed liquid formulation s do not lead to post

- application risk estimates of concern (all MOEs ≥100)

. Residential dermal post

- application MOEs for all life stages range from 2, 1 00 to 33,000. **Table 5.2. 3.**  **Residential Post -**  **Application Derm al Short**  **- Term Exposure and Risk Estim**  **ates from Gardens,**  **Ornam entals and Fruit Trees**  **. Scenario**  **Application**

**Rate (lb ai/A)**  **DF R**  **1**

**(μg/cm 2**  **) Exposure** 

**Tim e (hr)**  **Population TC**  **(cm 2**  **/hr) Daily Dose**  **2**

**(m g/k** **g/day) MOE**  **3** G ardens 0. 223 0.6 2 5 2.2 Adults 8,400 0.143 2,100 1.1 Children 6 to <11 yr old 4,600 0.0980 3,100 Tre es 0. 223 0.6 2 5 1. 0 Adults 1,700 0.0132 23,000 0.5 Children 6 to < 11 yr old 930 0.0090 33,000 1 DF R derived as follows: 0

. 223 lb ai/A x 4.54E+8 μg/lb x 2.47E

- 8 A/cm2 x 0.25 (fraction of transferable ai) = 0. 625 μg/cm2

. 2 Daily Dose = [ DF R (μg/cm2 ) x (0.001 mg/μg) x Dermal Transfer Coefficient x Exposure Time] / [Body weight (80 kg for adults a nd 32 kg for children 6 to <11 yr)]. 3 MOE = N OAEL/Daily Dose. Short

- Term N OAEL = 300 mg/kg/day. 

### 5.3 **Combined Residential Risk Estimates (Multiple Exposure Scenarios)** Residential handler and post

- application scenarios should generall y not be combined. Although there is potential for the same individual (i.e., adult) to apply a pesticide in and around the home and be exposed b y reentering a treated area in the same day, this is unlikely to occur day after day for 3 0 day s. Combining both of these exposure scenarios would also be inappropriate because of the conservative nature of each individual assessment. Since the application rates are different for turf and ornamental plants/trees, and because of the conservative nature of the individual turf and gardens/trees assessments, these scenarios were not combined. **5.4 Residential Risk Estimates for Use in Aggregate Assessment**  Table 5.4 .1 reflects the residential risk estimates that are recommended for use i n the aggregate assessment for fluop yr am .
 The recommended residential exposure for use in the adult aggregate assessment reflects inhalation handler exposure from treating lawns from by hose

- end sprayer.  The recommended residential exposure for use in the children (1 to <2 years old) aggregate assessment reflects incidental oral hand

- to - mouth post

- application exposure to treated lawns

.

### Page **33** of **59**

**Table 5**  **. 4**  **.1. Recommendations for the Residential Exposures for the Fl uopyram** **Aggregate Assessment. Lifestage**  **Dose (m** **g/k g/day)**  **4 MOE**  **5** Adults [inhalation handler exposure from treating lawns by hose

- end sprayer] 0.000056 260,000 Child (1 to <2 years old) [incidental oral hand

- to - mouth post

- application exposure to treated lawns] 0.00615 2,400 

### 5 **. 5**  **Spray Drift** Spray drift is a potential source of exposure to those nearby pesticide applications. This is particularl y the case with aerial application, but, to a lesser extent, spray drift can also be a potential source of exposure from the ground application methods (e.g., groundboom and airblast) emplo yed for fluopyram **.** The agency has been working with the Spray Drift Task Force (a task force composed of various registrants which was developed as a result of a Data Call

- In issued by EPA), EPA Regional Offices and State Lead Agencies for pesticide regulation and other parties to develop the best spray drift management practices (see the agency ’s Spray Drift website for more information). 6 

### The agency has also developed a policy on how to appropriatel y consider spray drift as a potential source of exposure in risk assessm ents for pesticides. The potential for spray drift will be quantitatively evaluated for each pesticide during the Registration Review process which ensures that all uses for that pesticide will be considered concurrently . The approach is outlined in the revised (2012) Standard Operating Procedures For Residential Risk Assessment (SOPs)

- Residential Exposure Assessment Standard Operating Procedures Addenda 1: Consideration of Spray Drift. This document outlines the quantification of indirect non

- occupati onal exposure to drift. **5 .**  **6 Residential Bystander Post**  **- Application Inhalation Exposure**  Volatilization of pesticides may be a source of post

- application inhalation exposure to individuals nearb y pesticide applications. The agency sought expert advice a nd input on issues related to volatilization of pesticides from its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory

Panel (SAP) in December 2009, and received the SAP’s final report on March 2, 2010 (http://www.regulations.gov/#!doc umentDetail;D=EPA

- HQ
- OPP
- 2009
- 0687
- 0037 ). The agency

has evaluated the SAP report and has developed a Volatilization Screening Tool and a subsequent Volatilization Screening Analy sis (http://www.regulations.gov/#!docketDetail;D=EPA

- HQ
- OPP
- 2014
- 0219). During Registration Review, the Agency

will utilize this analy sis to determine if data (i.e., flux studies, route

- specific inhalation toxicological studies) or further anal ys is is required for fluopy ram. In addition to this screen, the Agency has developed a preliminary by stander volatilization inhalation exposure assessment for fluop yram utilizing the currently available inhalation toxicity and air monitoring data.

6 Available: http://www2.epa.gov/reducing

-pes ticide

- drift

### Page **34** of **59**

**6 .0**  **Occupational Exposure and Risk Estimates**  **6 .1**  **Occupational Handler Exposure/Risk Estimates**  HED uses the term handlers to describe those individuals who are involved in the pesticide application process. HED believes that there are distinct job functions or tasks related to applications and exposures can vary depending on the specifi cs of each task. Job requirements (amount of chemical used in each application), the kinds of equipment used, the target being treated, and the level of protection used b y a handler can cause exposure levels to differ in a manner specific to each application event. Based on the anticipated use patterns and proposed labeling, types of equipment and techniques that can potentially

be used, occupational handler exposure is expected from the proposed uses. The quantitative dermal and inhalation exposure/ri sk assessment developed for occupational handlers is based on the following scenarios: 1) Mixing/loading liquids for aerial and chemigation application , 2) Mixing/loading liquids for groundboom application, 3) Mixing/loading liquids for airblast application, 4) Applying spray s via aerial equipment, 5) Applying spray s via groundboom equipment , 6) Applying spray s via airblast equipment, 7) Flagging for aerial sprays, 8) Mixing, loading, and applying liquids with manually pressurized handwand, 9) Mixing, loading, and applying liquids with m echanically

- pressurized handgun, and 10) Mixing, loading, and applying liquids with a backpack

. Occupational Agricultural Handler Exposure Data and Assumptions A series of assumptions and exposure factors served as the basis for completing the occupational handler risk assessments. Each assumption and factor is detailed below on an individual basis. Application Rate : A summary of the m aximum application rates for each crop or use site are provided in Table 4.1. Unit Exposures: It is the po licy of HED to use the best available data to assess handler exposure. Sources of generic handler data, used as surrogate data in the absence of chemical

- specific data, include PHED 1.1, the AHETF database, or other registrant

- submitted occupational expos ure studies. Some of these data are proprietary (e.g., AHETF data), and subject to the data protection provisions of FIFRA. The standard values recommended for use in predicting handler exposure that are used in this assessment, known as “unit exposures” , are outlined in the “Occupational Pesticide Handler Unit Exposure Surrogate Reference Table 7 

### ”, which, along with

7 Available: http://www.epa.gov/opp00001/science/handler

- exposure - table.pdf

### Page **35** of **59**

additional information on HED policy on use of surrogate data, including descriptions of the various sources, can be found at the Agency webs ite 8



### . Area Treated or Amount Handled: The daily areas treated or amounts handled were defined for each handler scenario (in appropriate units) b y determining the amount that can be reasonably treated b y an individual in a single day . When possible, the assumptions for daily areas treated or amounts handled are taken from the HED’s ExpoSAC Policy 9 .1 : “Standard Values for Daily Acres Treated in Agriculture”. Exposure Duration: HED classifies exposures from 1 to 30 day s as short

- term and exposures 30 day s to six months as intermediate

- term. Exposure duration is determined by many things, including the exposed population, the use site, the pest pressure triggering the use of the pesticide, and the cultural practices surrounding that use site. For most agricultural uses, it is reasonable to believe that occupational handlers will not apply the same chemical every day for more than a one

- month time frame; however, there may be a large agribusiness and/or commercial applicators who may appl y a product over a period of weeks (e.g., completing multiple applications for multiple clients within a region). For fluop yr am , based on the existing labeled use patterns , short

- and intermediate

- term exposures are expected

. Long
- term exposure is not expected based on the proposed use patterns

. Mitigation/Personal Protective Equipment: Occupational handler exposure assessments are completed b y HED using different levels of risk mitigation. Typicall y, HED uses a tiered approach. The lowest tier is designed as the baseline exposure scenario (i.e., long

- sleeve shirt, long pants, shoes, socks, no respirator). If risk estimates are of concern at baseline attire, then increasing levels of PPE (i.e., gloves, respirators) are evaluated. This approach is used to ensure that the lowest level of risk mitigation that provides adequate protection is selected

. Estimates of dermal and inhalation exposure were calculated for “baseline,” defined as a single layer of clothing consisting of a long sleeved shirt, long pants, shoes plus socks, no protective gloves, and no respirator. The fluopy ram product label s direct mixers, loaders, applicators and other handlers to wear long

- sleeved shirt and long pants, and chemical resistant gloves

. Occupational Handler Non

- Cancer Expo sure and Risk Estimate Equations The algorithms used to estimate non - cancer exposure and dose for occupational handlers can be found in Appendix A
. Summary of Occupational Handler Non

- Cancer Exposure and Risk Estimates For all exposure scenarios the risk estimates do not exceed HED’s LOC ( i.e., MOEs ≥100) at baseline clothing (i.e. , long sleeved shirt, long pants, shoes plus socks , without gloves or a respirator). The MOEs ranged from 410 to 1,500,000 for dermal exposure with baseline clothing , 2,400 to 1,100,000 for dermal exposure with the addition of gloves, and 7,400 to 3 0,0 00,000 for inhalation exposure . See Table 6.1 .1 for the summary of occupational handler risk estimates.

8 Available: http://www.epa.gov/pesticides/science/handler

- exposure - data.html

### Page **36** of **59**

**Table 6.1**  **. 1.**  **Occupational Short -**  **and Intermediate -**  **Term Dermal and Inhalation Exposures and Risk**  **Estimates For Fluopyram**
Exposure Scenario Crop or Target Maximum Application Rate a (lb ai/A) Ar ea

Treated or Amount Handled Daily b (A/day) Unit Exposure d Daily Exposure e (mg/kg/day) MOE f

Baseline Dermal c (mg/lb ai) PPE
- G

Dermal c (mg/lb ai) Baseline

Inhalation c (μg/lb ai) Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation
**Mixer/Loader**

Mixing/Loading Li quid Concentrates for Aerial and Chemigation Applications Artichoke (globe); Brassica (cole)

Leafy Vegetables; Bulb Vegetables; Carrot; Citrus; Cucurbit Vegetables; Fruiting Vegetables; Ginseng; Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Herbs and Spices (except Black Pepper); Hops; Leafy Vegetables; Pome Fruit; Other Root, Tuberous and Corm Vegetables; Small Berries (Caneberries and Bushberries); Stone Fruit; Strawberry and Other Low
- Growing Berries 0.222 350

0.22 0.0376 0.219 0.214 0.0365 2.13E
- 4 1,400 8,200 68,000

Brassica Leafy Vegetables Head and

Stem Subgroup 0.125 350 0.120 0.0206 1.20E
- 4 2,500 15,000 120,000 Canola Subgroup; Cereal grains; Forage, Fodder, or Straw from Cereal Grains; Cotton; Legume Vegetables (including Soybean); Potato; Sugar Beet; Sunflower

subgroup 0.222 1200 0.733 0.125 7.29E
- 4 410 2,400 20,000 Nursery (ornamentals, vegetables, trees, container stock) 0.131 60 0.0216 0.00370 2.15E
- 5 14,000 81,000 670,000 Sod 0.446 350 0.429 0.0734 4.28E
- 4 700 4,100 34,000

Mixing/Loading Li quids Concentrates for Gr oundboom Applications Artichoke (globe); Brassica (cole)

Leafy Vegetables; Bulb Vegetables; Carrot; Citrus; Cucurbit Vegetables; Fruiting Vegetables; Ginseng; Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Herbs and Spice s (except Black Pepper); Hops; Leafy Vegetables; Pome Fruit; Other Root, Tuberous and Corm Vegetables; Small Berries (Caneberries and Bushberries); Stone Fruit; Strawberry and Other Low
- Growing Berries 0.222 80 0.22 0.0376 0.219 0.0489 0.00835 4.86E
- 5 6,00 36,000 300,000

Brassica Leafy Vegetables Head and

Stem Subgroup 0.125 80 0.0275 0.00470 2.74E
- 5 11,000 64,000 530,000

### Page **37** of **59**

**Table 6.1**  **. 1.**  **Occupational Short -**  **and Intermediate -**  **Term Dermal and Inhalation Exposures and Risk**  **Estimates For Fluopyram**
Exposure Scenario Crop or Target Maximum Application Rate a (lb ai/A) Ar ea

Treated or Amount Handled Daily b (A/day) Unit Exposure d Daily Exposure e (mg/kg/day) MOE f

Baseline Dermal c (mg/lb ai) PPE
- G

Dermal c (mg/lb ai) Baseline

Inhalation c (μg/lb ai) Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation Canola Subgroup; Cereal grains; Forage, Fodder, or Straw from Cereal Grains; Cotton; Legume Vegetables (including Soybean); Potato; Sugar Beet; Sunflower

subgroup 0.222 200 0.122 0.0209 1.22E
- 4 2,500 14,000 120,000

Field Grown Ornamentals 0.131 40 0.0144 0.00246 1.44E
- 5 21,000 120,000 1.0E+6 Nursery (ornamentals, vegetables, trees, container stock) 0.131 60 0.0216 0.0037 2.15E
- 5 14,000 81,000 670,000 Sod 0.446 80 0.0981 0.0168 9.76E
- 5 3,100 18,000 150,000 Turf 0.446 40 0.0490 0.00839 4.89E
- 5 6,100 36,000 300,000 Mixing/Loading Li quids Concentrates for Airblast Applications Nursery (ornamentals, vegetables, trees, container stock) 0.131 20 0.22 0.0376 0.219 0.00720 0.00123 7.18E
- 6 42,000 240,000 2.0E+6 Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Pome Fruit; Stone Fruit; 0.222 40 0.0244 0.00418 2.43E
- 5 12,000 72,000 600,000 **Applicator**

Applying Sprays via Aerial Equipment Artichoke (globe); Brassica (cole)

Leafy Vegetables; Bulb Vegetables; Carrot; Citrus; Cucurbit Vegetables; Fruiting Vegetables; Ginseng; Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Herbs and Spice s (except Black Pepper); Hops; Leafy Vegetables; Pome Fruit; Other Root, Tuberous and Corm Vegetables; Small Berries (Caneberries and Bushberries); Stone Fruit; Strawberry and Other Low
- Growing Berries 0.222 350

0.00208 g No Data 0.0049 g 0.00203 No Data 4.7 6E
- 6 150,000 No Data 3.0E+6

Brassica Leafy Vegetables Head and

Stem Subgroup 0.125 350 0.00114 No Data 2.68E
- 6 260,000 No Data 5.4E+6 Canola Subgroup; Cereal grains; Forage, Fodder, or Straw from Cereal Grains; Cotton; Legume Vegetables (including Soybean); Potato; Sugar Beet; Sunflower

subgroup 0.22 1200 0.00693 No Data 1.64E
- 5 43,000 No Data 880,000 Nursery (ornamentals, vegetables, trees, container stock) 0.131 60 0.00020 4 No Data 4.81E
- 7 1.5E+6 No Data 3.0E+7 Sod 0.446 350 0.00406 No Data 9.56E
- 6 74,000 No Data 1.5E+6

### Page **38** of **59**

**Table 6.1**  **. 1.**  **Occupational Short -**  **and Intermediate -**  **Term Dermal and Inhalation Exposures and Risk**  **Estimates For Fluopyram**
Exposure Scenario Crop or Target Maximum Application Rate a (lb ai/A) Ar ea

Treated or Amount Handled Daily b (A/day) Unit Exposure d Daily Exposure e (mg/kg/day) MOE f

Baseline Dermal c (mg/lb ai) PPE
- G

Dermal c (mg/lb ai) Baseline

Inhalation c (μg/lb ai) Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation

Applying Sprays via Gr oundboom Equipment Artichoke (globe); Brassica (cole)

Leafy Vegetables; Bulb Vegetables; Carrot; Citrus; Cucurbit Vegetables; Fruiting Vegetables; Ginseng; Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Herbs and Spices (except Black Pepper); Hops; Leafy Vegetables; Pome Fruit; Other Root, Tub erous and Corm Vegetables; Small Berries (Caneberries and Bushberries); Stone Fruit; Strawberry and Other Low
- Growing Berries 0.222 80

0.0786 0.0161 0.34 0.0175 0.00358 7.55E
- 5 17,000 84,000 190,000

Brassica Leafy Vegetables Head and

Stem Subgroup 0.125 80 0.00983 0.00201 4.25E
- 5 31,000 150,000 340,000 Canola Subgroup; Cereal grains; Forage, Fodder, or Straw from Cereal Grains; Cotton; Legume Vegetables (including Soybean); Potato; Sugar Beet; Sunflower

subgroup 0.222 200 0.0436 0.00894 1.89E
- 4 6,900 34,000 77,000

Field Grown Ornamentals 0.131 40 0.00515 0.00106 2.23E
- 5 58,000 280,000 650,000 Nursery (ornamentals, vegetables, trees, container stock) 0.131 60 0.00773 0.00159 3.34E
- 5 39,000 190,000 430,000 Sod 0.446 80 0.0175 0.00359 7.59E
- 5 17,000 84,000 190,000 Turf 0.446 40 0.0350 0.00718 1.51E
- 4 8,600 42,000 96,000 Applying Sprays via Airblast Equipment Nursery (ornamentals, vegetables,

trees, container stock) 0.222 20 1.77 1.59 4.71 0.0580 0.0521 1.54E
- 4 5,200 5,800 94,000 Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Pome Fruit; Stone Fruit 0.131 40 0.196 0.176 5.23E
- 4 1,500 1,700 28,000 **Flagger**

Flagging for Aerial Sprays Applications Artichoke (globe); Brassica (cole)

Leafy Vegetables; Bulb Vegetables; Carrot; Citrus; Cucurbit Vegetables; Fruiting Vegetables; Ginseng; Grapes and Small Vine Fruits (except Fuzzy Kiwifruit); Herbs and Spices (except Black Pepper); Hops; Leafy Vegetables; Pome Fruit; Other Root, Tub erous and Corm Vegetables; Small Berries 0.222 350 0.011 0.012 0.35 0.0107 0.0117 3.40E
- 4 28,000 26,000 43,000

### Page **39** of **59**

**Table 6.1**  **. 1.**  **Occupational Short -**  **and Intermediate -**  **Term Dermal and Inhalation Exposures and Risk**  **Estimates For Fluopyram**
Exposure Scenario Crop or Target Maximum Application Rate a (lb ai/A) Ar ea

Treated or Amount Handled Daily b (A/day) Unit Exposure d Daily Exposure e (mg/kg/day) MOE f

Baseline Dermal c (mg/lb ai) PPE
- G

Dermal c (mg/lb ai) Baseline

Inhalation c (μg/lb ai) Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation (Caneberries and Bushberries); Stone Fruit; Strawberry and Other Low
- Growing Berries Brassica Leafy Vegetables Head and

Stem Subgroup 0.125 350 0.00601 0.00656 1.91E
- 4 50,000 46,000 76,000 Canola Subgroup; Cereal grains; Forage, Fodder, or Straw from Cereal Grains; Cotton; Legume Vegetables (including Soybean); Potato; Sugar Beet; Sunflower

subgroup 0.22 1200 0.0366 0.040 0.00117 8,200 7,500 12,000 Nursery (ornamentals, vegetables, trees, container stock) 0.131 60 0.00108 0.00118 3.44E
- 5 280,000 250,000 420,000 Sod 0.446 350 0.0215 0.0234 6.83E
- 4 14,000 13,000 21,000 **Mixer/Loader/Applicator** Mixing/Loading /Applying Li quid Concentrates with Manually Pressurized Handwand Gr eenhouse Ornamentals 0.00131 lb ai/gal 40 gal 100 0.43 30 0.0655 2.81E
- 4 1.96E
- 5 4,600 1.1E+6 740,000 Nursery (ornamentals, vegetables, trees, container stock) 0.00131 lb ai/gal 0.0655 2.81E
- 4 1.96E
- 5 4,600 1.1E+6 740,000 Christmas Trees 0.00223 lb ai/gal 0.112 4.80E
- 4 3.35E
- 5 2,700 630,000 430,000 Turf 0.0026 lb ai/gal 0.130 5.59E
- 4 3.90E
- 5 2,300 540,000 370,000 Mixing/Loading /Applying Li quid Concentrates with Mechanically

Pressurized Handgun Gr eenhouse Ornamentals 0.00131 lb ai/gal 1000 gal 3.5 2.5 120 0.0574 0.0410 0.00196 5,200 7,300 7,400 Nursery (ornamentals, vegetables, trees, container stock) 0.00131 lb ai/gal 1000 gal 1.3 0.39 3.9 0.0213 0.00639 6.39E
- 5 14,000 47,000 230,000 Christmas Trees 0.00223 lb ai/gal 1000 gal 0.0363 0.0109 1.09E
- 4 8,300 28,000 130,000 Pome Fruit; Stone Fruit 0.0222 lb ai/gal 1000 gal 0.361 0.108 0.00108 830 2,800 13,000 Golf Course; Turf 0.446 5 1.14 0.88 1.9 0.0318 0.0245 5.30E
- 5 9,400 12,000 270,000 Mixing/Loading /Applying Li quid Concentrates with a Backpack Nursery (ornamentals, vegetables,

trees, container stock) 0.00131 lb ai/gal 40 gal 13.2 11.2 140 0.00865 0.00734 1.98E
- 5 35,000 41,000 160,000 Christmas Trees 0.00223 lb ai/gal 0.0148 0.0125 1.56E
- 4 20,000 24,000 93,000 Pome Fruit; Stone Fruit 0.0222 lb ai/gal 8.26 8.26 2.58 0.0916 0.0916 2.86E
- 5 3,300 3,300 510,000

### Page **40** of **59**

**Table 6.1**  **. 1.**  **Occupational Short -**  **and Intermediate -**  **Term Dermal and Inhalation Exposures and Risk**  **Estimates For Fluopyram**
Exposure Scenario Crop or Target Maximum Application Rate a (lb ai/A) Ar ea

Treated or Amount Handled Daily b (A/day) Unit Exposure d Daily Exposure e (mg/kg/day) MOE f

Baseline Dermal c (mg/lb ai) PPE
- G

Dermal c (mg/lb ai) Baseline

Inhalation c (μg/lb ai) Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation Baseline

Dermal PPE
- G

Dermal Baseline

Inhalation

Turf 0.0026 lb ai/gal 0.0107 0.0107 3.35E
- 6 28,000 28,000 4.3E+6 a. Application Rates are based on proposed uses from the proposed fluopyram labels. b. Science Advisory Council Policy No. 9.1. c. Baseline Dermal: Long

- sleeve shirt, long pants, and no gloves. PPE
- G Dermal: Baseline plus chemical

- resistant gloves. Baseline I nhalation: no respirator. d. U nit Exposures are based on “Occupational Pesticide Handler Unit Exposure Surrogate Reference Table”. e. Daily Exposure (mg/kg/day) = Application Rate (lb ai/A) * Unit Exposure (mg/lb ai) * Area Treated or Amount Applied (acre/day) / 80 kg. f. MOE = NOAEL (mg/kg/day) / Daily Exposure (mg/kg/day); where dermal NOAEL = 300 mg/kg/day and inhalation NOAEL = 14.5 mg/kg/day. g. Engineering c ontrol unit exposure for applying sprays via aerial equipment = enclosed cockpit.

### Page **41** of **59**

**Seed Treatment Use on Peanut**  **Seeds** Based on the anticipated use patterns and labeling, ty pes of equipment and techniques that can potentially

be used, occupational handler exposure is expected from the proposed seed treatment of peanuts . The quantitative exposure/risk assessm ent developed for occupational handlers is based on the following scenarios: 1. Mixing/loading liquids f or commercial seed treatment, 2. Bagging treated seed, 3. Sewing bags, 4. Multiple activities, and 5. Planting treated seed. Occupational seed treatment handlers may experience short

- and intermediate

- term exposure to fluopy ram while performing seed treatment activities in commercial settings. In addition, occupational secondary

handlers may

experience short

- and intermediate

- term exposure while planting fluop yr am - treated seeds. No chemical

- specific handler exposure data were submitted in support of this use pattern. For assessing commercial seed treatment and seed planting activities, unit exposure data were taken from HED ExpoSAC Policy 14: SOPs for Seed Treatm ent. The amount of ai handled depends on the application rate (lb ai/lb seed) and the pounds of seed treated in a day

(or the pounds of seed that can be planted in a day), all of which vary depending upon the seed type. Values for the amount of seed treated and planted per day were obtained from HED ExpoSAC Policy 15 and 15.1. Treating Seed (Primary

Handler) Potential occupational exposure scenarios from the use of fluop yr am as a commercial seed treatment include: mixing, loading, appl yi ng liquid formulations; bagging treated seed; sewing bags; and multiple activities. Ty pically , for large

- scale commercial seed treatments, workers perform onl y those specific individual tasks listed above; however, it is assumed that workers also may perform multiple activities throughout the day . As a result a “multiple activities” scenario (i.e. where one worker performs all seed treatment tasks such as loading/appl yi n g, sewing, bagging, cleaning, calibration, repair, forklift driver, etc.) was addressed. Planting Treated Seed (Secondary Handler) Potential occupational exposure scenarios from the use of fluo py ram as a commercial seed treatment include planting treated seed (secondary handler). Planting treated seed consists of the farmer purchasing bags of treated seed, placing the seed in the hopper and applying seed to fields (considered a secondary

handler exposure scenario). Occupational Handler Exposure Data and Assumptions A series of assumptions and exposure factors served as the basis for completing the occupational handler risk assessments. Each assumption and factor is detailed below on an individual basis. Application Rate : Refer to the proposed use patt ern table in Section 4.0 for a detailed description

.

### Page **42** of **59**

Unit Exposures: It is the policy of HED to use the best available data to assess handler exposure. Chemical

- specific data for assessing exposure during commercial seed treatment and seed planting were not submitted to the Agency in support of these applications. Unit exposures are from ExpoSAC Policy

14: SOPs for Seed Treatment (May 1, 2003) and are based on data for open mixing/loading/application sy stems. Amount Handled: HED is currently

in the process of revising ExpoSAC Policy 15: Amount of Seed Treated or Planted per Day

(March 2, 2004) in efforts to update the dail y amount of seed treated in commercial seed treatment facilities. With the increasing demand for hybridized treated seeds, there have been modifications not only in the seed treatment equipment, but in the market shares of new and currently

registered pesticide products. HED understands that due to the high cost of producing hybrid seeds, direct seeding is done in a precision manner which requires lower volumes of seed per acre. However, this does not provide a direct correlation to the amount of seed which is treated in the commercial seed treatment facilities. The amount of seed handled (for both primary /treater and secondary

/pl anter handlers) is based on HED ExpoSAC Policy 15, HED ExpoSAC Policy SOP 15.1, and the BEAD memo: “Acres Planted Per Day

and Seeding Rates of Crops Grown in the United States.”

 The amount of peanut seed treated per day at a commercial facility

for short

- term exposure durations is 339,500 lb.

 Amount of s eed p lanted per acre (ASP, lb seed/A) for peanut is 228 lb seed/A ( 105,000 seeds/A x lb peanut seeds/460 peanut seeds )

.
 The amount of seed planted per acre per day for peanut is 18,260 lb ( 228 lb seed/A × 8 0 A/day). Exposure Duration: HED classifies exposures from 1 to 30 day s as short

- term and exposures 30 day s to six months as intermediate

- term. Mitigation/Personal Protective Equipment: Results are presented for PPE (gloves); defined as a single layer of clothing consisting of a long sleeved shirt, long pants, shoes plus socks, protective gloves, and no respirator for all scenarios, except bagging and sewing, for which “baseline ” attire was evaluated

. Occupational Handler Non

- Cancer Expos ure and Risk Estimate Equations The algorithms used to estimate non

- cancer exposure and dose for occupational handlers can be found in Appendix A. Summary of Occupational Handler Non

- Cancer Exposure and Risk Estimates The results of the occupational handl er exposure and risk assessment indicate that short

- term dermal and inhalation risk estimate s do not exceed HED’s LOC (i.e. , an MOE < 100 for short

term exposures). Short

- term exposure risk estimates are protective of intermediate

- term exposure risk estim ates because the throughput (amount of seed treated) of short

- term exposure

### Page **43** of **59**

is greater than, or equal to, the throughput of intermediate

- term exposure. The dermal MOEs range from 1,4 00 to 9 , 2 00 for handlers (treaters and planters). The inhalation MOEs range from 1,7 00 to 15 ,000 for handlers (treaters and planters). Because the short

- and intermediate

- term dermal and inhalation PODs are the same, and the intermediate

- term exposure inputs are less conservative than the short

- term exposure inputs for seed treatment, short

- term exposure risk estimates are protective of intermediate

- term exposure risk estimates. **Table 6 .**  **1 .2**  **. Summary of Short**  **- and Interm**  **ediate -**  **Term Handler Exposures and Risk Estim ates for**  **Fluopyram Seed Treatment of**  **P eanut Seed**  **.** a Maximum Application Rate b lb ai/lb seed Amount of

Seed Treated or Planted Per Dayd lb seed/day Dermal

Unit Exposure c mg/lb Inhalation

Unit Exposure c mg/lb Dermal

Dose e mg/kg/day Inhalation

Dose f mg/kg/day Dermal

MOE f LOC = 100 Inhalation

MOE h LOC = 100 **Loader/Applicator** 0.001245 339,5 00 0.023 0.00034 0. 1215 0.00 1796 2,5 00 8,100 **Sewer** 0.001245 339,5 00 0.0062 0.00023 0.0 3276 0.00 1215 9,200 12,000 **Bagger** 0.001245 339,5 00 0.0091 0.00016 0.0 4808 0.00 08454 6,200 17,000 **Multiple Activities** 0.001245 339,5 00 0.042 0.0016 0. 2219 0.0 08454 1,400 1,700 **Planters** 0.001245 18,260 0.25 0.0034 0.0 7104 0.000 9662 4,200 15,000
a Seed treatment rate calculations are based on the following assumptions: Peanut : 460 seeds per lb; 228 lb of seed planted per acre, 80 acres planted per day. b Application Rate based on proposed label for fluopyram ( Luna Privilege , EPA Reg. No. 264
- 1078 ). c Unit Exposures from HED Exposure Science Advisory Council Policy 14: Standard Operating Procedures for Seed Treatment (baseline inhalation = no respirator ; dermal unit exposure includes PPE with gloves for loading/applicator, multiple activities and planter scenari os ). d HED default for lb seed treated/planted per day from HED Exposure Science Advisory Council I nterim Policy 15.1 and the BEAD memo “Acres Planted Per Day and Seeding Rates of Crops Grown in the United States” (J. Becker, March 2011). e Daily Dermal Dose (mg/kg/day) = daily dermal unit exposure (mg/lb ai) × application rate (lb ai/lb seed) × amount planted (lb seed/d ay) ÷ body weight (80 kg adult). f Daily I nhalation Dose (mg/kg/day) = daily inhalation unit exposure (mg/lb ai) × application rate (lb ai/lb seed) × amount planted (lb seed/day) ÷ body weight (80 kg adult). g Dermal MOE = NOAEL (300 mg/kg/day for short

- and intermediate

- term exposure) ÷ Dermal Dose (mg/kg/day). Level of concern = 100. h Inhalation MOE = NOAEL ( 14.5 mg/kg/day for short

- and intermediate

- term exposure) ÷ I nhalation Dose (mg/kg/day). L evel of concern = 100. 

### 6 **. 2**  **Occupational Post** **- application**  **Exposure/ Risk**  **Estimates** HED uses the term post

- application to describe exposures that occur when individuals are present in an environment that has been previously treated with a pesticide (also referred to as re

entry exposure). Such exposures may occur when workers enter previously treated areas to perform job functions, including activities related to crop production, such as scouting for pests or harvesting. Post

- application exposure levels vary over time and depend o n such things as the ty pe of activity , the nature of the crop or target that was treated, the ty pe of pesticide application,

### Page **44** of **59**

and the chemical’s degradation properties. In addition, the timing of pesticide applications, relative to harvest activities, can greatl y reduce the potential for post

- application exposure. **6 .**  **2 .1**  **Occupational Post** **- application**  **Inhalation Exposure/Risk Estimates**  There are multiple potential sources of post

- application inhalation exposure to individuals performing post

- application acti vities in previously treated fields. These potential sources include volatilization of pesticides and resuspension of dusts and/or particulates that contain pesticides. The agency

sought expert advice and input on issues related to volatilization of pesticides from its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (SAP) in December 2009, and received the SAP’s final report on March 2, 2010 (http://www.epa.gov/scipoly /SAP/meetings/2009/120109meeting.html ). The agency has ev aluated the SAP report and has developed a Volatilization Screening Tool and a subsequent Volatilization Screening Analy sis (http://www.regulations.gov/#!docketDetail;D=E PA
- HQ
OPP
- 2014
- 0219 ). During Registration Review, the agency will utilize this anal ys is to determine if data (i.e., flux studies, route

- specific inhalation toxicological studies) or further anal ys is is required for fluop yr am. In addition, the Agency

is c ontinuing to evaluate the available post

- application inhalation exposure data generated by the Agricultural Reentry Task Force. Given these two efforts, the Agency will continue to identify

the need for and, subsequently , the way to incorporate occupation al post

- application inhalation exposure into the agency's risk assessments. Although a quantitative occupational post

- application inhalation exposure assessment was not performed, an inhalation exposure assessment was performed for occupational/commercial handlers. Handler exposure resulting from application of pesticides outdoors is likely to result in higher exposure than post

- application exposure. Therefore, it is expected that these handler inhalation exposure estimates would be protective of most oc cupational post

- application inhalation exposure scenarios. **6 .**  **2 .2**  **Occupational Post -**  **application Dermal Exposure/Risk Estimates**  **Use on Agricultural Field Crops**  Occupational Post
- application Dermal Exposure Data and Assumptions In addition to the application rate and body weight values discussed above in the handler exposure section, the following assumptions were made in assessing short

- and intermediate

term dermal post

- application risks : Dislodgeable F oliar Residues: There were no chemical

- specific dislodgeable foliar residue data to assess post

- application risks to workers while performing tasks related to crops treated with fluop yr am . For agricultural crops, o ccupational post

- application exposures and risks were ass essed using HED’s default assumptions that 2 5 % of the initial application is available for transfer on day 0 (i.e., 12 hours after application) and that the residue dissipates at a rate of 10 % per day

.

### Page **45** of **59**

In accordance with 40 CFR § 158, DFR data are required for all occupational (e.g., crop, nursery , greenhouse use sites) or residential (e.g., ornamental and vegetable gardens, pick your own farms, retail tree farms) uses that could result in post

- application exposure to foliage. In the absence of chemical

- specific DFR data, EPA uses default values. The 2012 Standard Operating Procedures for Residential Pesticide Exposure Assessment includes an analy sis of a number of DFR studies, which resulted in the selection of a revised defa ult values for the fraction of the application rate available for transfer after a foliar application (F AR

### ). These values are based on an anal ys is of 19 DFR studies. Since that time, the Agricultural Re

- entry Task Force has submitted information (MRID 49 299201) that corrects an application rate error made in the original submission of “ARF039

– Determination of Dermal and Inhalation Exposure to Reentry Workers During Chry santhemum Pinching in a Greenhouse” (EPA MRID 45344501). As a result, the range of F AR 

### values was revised from 2%

- 89% to 2%
- 47%. In the data, a large range of transferability

is observed and this variability can potentiall y be attributable to many factors such as active ingredient; formulation; field conditions in the studies; weather conditions (e.g., humidity); or many other difficult to quantify factors. Although witnessed across multiple chemicals, this range in F AR 

### values is not expected when considering DFR data for a single chemical. At this time, the ARTF submission did not alter the selection of 25% as the reasonable, high

- end default value. Because DFR data are not available for fluopy ram , EPA is using the default value of 25%. Although there may be a small degree of uncertainty in the use of the default DFR value for flu opy ram (i.e., there is a small chance that the F AR 

### value may exceed the applicable default value ), it is likely that the health

- protective aspects of EPA’s occupational post

- application assessment methodology will more than compensate for this potential un certainty. For example, when assessing residential and occupational post application exposure to gardens and ornamentals, EPA assumes the following: exposures occur to zero - day

(i.e., day of application ) residues every day of the assessed exposure duration (i.e., EPA assumes that no dissipation or degradation occurs, it doesn’t rain, etc); individuals perform the same post - application activities performed in the transfer coefficient study day after day (e.g., weeding, harvesting, pruning, etc.); and individuals engage in these post

- application activities for a high

- end amount of time every day (represented by

data reflecting time spent gardening based on survey data). Given the conservatisms discussed above and the potential compounding nature of these conservatisms, EPA is able to rely upon the calculated exposure estimates with confidence that exposure is not being underestimated. Since the highest estimated residential and occupational post

- application exposure s using default DFR values for fluop yram are minimal in comparison to the level of concern (i.e., the calculated MOE is greater than 2 times higher than the level of concern, residential MOE = 2,100 and occupational MOE = 250 compared to the LOC of 100 ); EPA is waiving the 40 CFR § 158 D FR data requirement. In this instance, it is unlikely that chemical

- specific DFR data would be needed to further refine exposure assessments or would add appreciabl y to our overall understanding of the availability of dislodgeable foliar pesticide residue s for fluopy ram .

### Page **46** of **59**

Turf Transferrable Residues A turf transferrable residue study has not been submitted for fluopy ram. Therefore, HED’s standard operating procedures and assumptions were used to determine an estimate of day zero fluopy ram residues on treated turf

. In accordance with 40 CFR § 158, TTR data are required for all occupational (e.g., sod farms, golf courses, parks, and recreational areas) or residential turf uses that could result in post

application exposure to turf. In the absence of chemical

- specific TTR data, EPA uses default values. The 2012 Standard Operating Procedures for Residential Pesticide Exposure Assessment includes an analy sis of all TTR data, available at the time, which resulted in the selection of revised l iquid and granular default values for the fraction of the application rate available for transfer after a turf application (F AR

### ). These values are based on an anal ys is of 59 TTR studies performed with the Modified California Roller Method (36 studies usin g liquids, 11 studies using wettable powders/water dispersible granules, and 12 studies using granules). The liquid results (N=131) indicate a range of F AR 

### values from 0.0005% to 6.1% and the granular results (N=37) indicate a range of 0.00064% to 0.69%. In both the liquid and granular data, a large range of transferability is observed and this variability can potentially

be attributable to many factors such as active ingredient; formulation; field conditions in the studies; weather conditions (e.g., humi dity); or many other difficult to quantify factors. Although witnessed across multiple chemicals, this range in F AR 

### values is not expected when considering TTR data for a single chemical. HED selected 1% and 0.2% as high

- end default values for liquid and granular products, respectively

. Because TTR data are not available for fluopy ram , EPA is using the default value of 1%
. Although there may be a small degree of uncertainty in the use of the default TTR value for fluopy ram (i.e., there is a small chance that the F AR 

### value may exceed the applicable default value ), it is likely that the health

- protective aspects of EPA’s residential and occupational post - application turf assessment methodology will more than compensate for this potential uncertainty (i.e., the methodology is likely to overestimate exposure by a factor greater than the factor than the highest measured F AR 

### values exceed the defaults ). For example, when assessing residential post

- application turf exposure, EPA assumes the following: exposure s occur to zero - day

(i.e., day of application ) residues every day of the assessed exposure duration (i.e., EPA assumes that no dissipation or degradation occurs, it doesn’t rain, the grass is not mowed, etc

. ); individuals perform the same post

- application activities performed in the turf transfer coefficient study day after day (e.g., tumbling, playing on turf with toy s, etc.); and individuals engage in these post

- application activities for a high

- end amount of time every day that is represented b y data re flecting time children spend outdoors and not specificall y engaged in activities on turf, when in actuality children do not spend all of their outdoor time on turf and high

- end levels of activity will not occur every

day

. Given the conservatisms discussed above and the potential compounding nature of these conservatisms, EPA is able to rely upon the calculated exposure estimates with confidence that exposure is not being underestimated. Since the estimated residential turf post

- application exposure from h igh contact activities on lawns and the occupational post

- application activities on golf course turf using default TTR values for fluop yr am are minimal in comparison to the level of concern (i.e., the calculated

### Page **47** of **59**

MOE s are greater than 10 times higher than the level of concern, residential MOE = 1,000 and occupational MOE = 9,000, compared to the LOC of 100 ); EPA is waiving the 40 CFR § 158 TTR data requirement. In this instance, it is unlikely that chemical

- specific TTR data would be needed to further refine exposure assessments or would add appreciabl y to our general understanding of the availability of turf transferable pesticide residues. Transfer Coefficients: HED uses a concept known as the transfer coefficient to numerically represent the post

application exposures one would receive (generally presented as cm2 

### /hour). A transfer coefficient is a measure of the residue transferred from a treated surface to a person who is doing a task or activity

in a treated area. These values are the ratio of an exposure for a given task or activity to the amount of pesticide residue on treated surfaces available for transfer. HED has developed a series of standard transfer coefficients that are unique for variety of job tasks or activities that are used in li eu of chemical

- and scenario

- specific data. No post
- application data were submitted in support of this registration action; therefore, dermal exposures during post

- application activities were estimated for the various tasks that post

application workers might perform on each crop grouping using dermal transfer coefficients from the Science Advisory Council for Exposure Policy Number 3 (http://www.epa.gov/pesticides/science/exposac_policy3.pdf). This policy reflects adoption of all ARTF data. Use of the data in this policy requires compensation to the ARTF under FIFRA. The transfer coefficients used in this assessment were taken from the Agency’s revised Agricultural Transfer Coefficient SOP. Many of the transfer coefficient s in this SOP are based on w ork of the ARTF. Workday : HED assumes an 8 hour workday for post

- application workers

. Equations and Calculations: Daily Dermal Exposure and default DFR calculations are presented below. The algorithms used to estimate dermal post

- application exposure and dose can be found in Appendix A. The post

- application dermal exposure and risk estimates associated with agricultural crops , Christmas trees, and nursery ornamentals are summarized in Table 6.2.2
. For each crop or crop group the post

- application activities with the highest transfer coefficient and highest exposure contact are presented. The occupational post

- application MOEs for all crops and crop groups and scenarios shown below do not exceed HED’ s level of concern (MOEs ≥100) on day 0 (i.e., 12 hours following application) with dermal MOEs ranging from 250 to 23,000. All other scenarios involving l ess er contact activities would have higher MOEs and are also not of concern.

### Page **48** of **59**

**Table 6**  **. 2.2.**  **Summary of Occupational Non**  **- Cancer Post**  **- application Risks (Short**  **- and Intermediate**  **- Term)**  **with HED Default Assumptions.** Crop s or Crop Groups Application

Rate (lb ai/acre) Default DFR on 0

days (12 hr) after application a ( μ g/cm

2 ) Work Activity &

Maximum Transfer Coefficient

b (cm 2/hr) Daily Dose c

(mg/kg/day) MOE d

(LOC = 100) Artichoke 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Brassica Leafy Vegetables Head & Stem Subgroup 0.125 0.350 4200 Hand Harvesting, Hand Weeding, Scouting, Topping, Tying/Training 0.147 2,000 Brassica Leafy Vegetables 0.222 0.622 4200 Hand Weeding 0.261 1,100 Bulb Vegetables 0.222 0.622 4200 Hand Weeding 0.261 1,100 Canola Subgroup 0.222 0.622 1100 Scouting 0.0684 4,400 Carrot 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Sweet Corn 0.222 0.622 17,600 Hand Detasseling, Hand Harvesting 1.09 270 Cereal Grains 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Forage, Fodder or Straw from Cereal Grains 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Citrus 0.222 0.622 1400 Hand Harvesting 0.0871 3,400 Cotton 0.222 0.622 210 Scouting 0.0131 23,000 Cucurbits 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Fruiting Vegetables 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Okra 0.167 0.468 1900 Irrigation (Hand Set) 0.0889 3,400 Ginseng 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Small Vine Fruits 0.222 0.622 10,100 Hand Harvesting 0.628 480 Herbs & Spices 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Hops 0.222 0.622 19,300 Harvesting, Mechanically Assisted 1.20 250 Leafy Vegetables 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Legume Vegetables 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Soybean 0.222 0.622 1100 Scouting 0.0684 4,400 Pome Fruit 0.222 0.622 3600 Thinning Fruit 0.224 1,300 Root, Tuberous & Corm Vegetables 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Small Berries 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Stone Fruit 0.222 0.622 3600 Thinning Fruit 0.224 1,300 Low Growing Berries 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Sugar Beet 0.222 0.622 1100 Hand Harvesting 0.0684 4,400 Sunflower 0.222 0.622 1900 Irrigation (Hand Set) 0.118 2,500 Christmas Tree s 0.223 0.625 1900 Irrigation (Hand Set) 0.119 2,500 Nursery Ornamentals 0.131 0.367 1900 Irrigation (Hand Set) 0.0697 4,300
a. Default DFR (μg/cm2 ) = application rate (lb ai/A) x (1

- daily dissipation rate) t x 4.54E+8 μg/lb x 24.7E

- 9 A/c m 2 x 2 5 % DFR after initial treatment. b. Crops were assessed using the highest transfer coefficient (TC) available. c. Daily Dose = DFR x TC x (1 mg/1000 μg) x ET (8 hr/day) / body weight ( 8 0 kg) d. MOE = NOAEL (300 mg/kg/day) / Daily Dose (mg/kg/day)

### Page **49** of **59**

For use on cotton, HED has also assessed the post - application dermal exposure and risk estimates for workers involved in harvesting cotton bolls. Although most of cotton harvesting is done mechanicall y, there are still some activities, with the potential for exposure, that are associated with the harvesting of cotton. The anticipated post

- applicatio n activities and dermal transfer coefficients for these activities are presented in Table 6.2. 3
. The recommended transfer coefficients are derived from EPA’s Science Advisory Council for Exposure (ExpoSAC) Policy 3 (http://www.epa.gov/pesticides/science/exposac

- policy3
- march2013.pdf ). No chemical specific data are available for the amount of residue available on the cotton bolls; i.e., dislodgeable boll residue (DBR) data. Such data are available from a study with the active ingredient tribufos; i.e., MRID 42701601. **Note to RD: These data may be proprietary, and**  **subject to the data protection provisions of FIFRA, and therefore, may tr**  **igger a data compensation issue between registrants.**  Since the proposed fluopy ram labels include a 30 day pre - harvest interval, the best fit residue data used from MRID 42701601 was chosen from 30 day s after harvest and then adjusted for the difference in application rates. All of the cotton harvesting activities resulted in MOEs ranging from 3,100,000 to 17,000,000, which do not exceed the LOC , and are therefore not of concern ; see Table 6.2.4. **Table 6.2.3. Anticipated Post -**  **Application Activities and T ransfer Coefficients for Cotton Harvesters**  **. Crop**  **Policy Crop**

**Group Category Crop** 

**Height Foliage** 

**Density Transfer Coefficients**  **Activities**

Cotton Field / row . crop,

low / medium High Min 900 g cotton boll/hr Mechanical Harvesting (Module Builder Operator) 2 , 400 g cotton boll/hr Mechanical Harvesting (Picker Operator and Raker) 5 , 050 g cotton boll/hr Mechanical Harvesting (Tramper) **Table 6.2.4. Occupational Post**  **- application**  **Exposure and Risk Estimates for Cotton Harvesting**  **Activities. Mechanical Harvesting**  **Activity Appl. Rate**  **(lb ai/A) D**  **B R** 

**( μ**  **g/ g**  **) 1**  **Transfer**

**Coefficient (**  **g /hr)**  **2 Derm**  **al Dose 3** 

**(m g/kg/day)**  **Derm al** 

**MOE 4**  Module Builder Operator 0. 222 0.00019 4 90 0 0.000 0 1 75 1 7,0 00,000 Picker Operator and Raker 2,400 0.0000466 6,400,000 Tram per 5,05 00 0.00 00981 3, 1 00 ,000 1. Cotton Harvesting Dislodgeable Boll Residue (DB R) = (Best fit D B R at 30 days MRID# 42701601 (0.082 μg/50g = 0.00164 μg/g) x Application Rate (0.222 lb ai/A)) / Study Application Rate (1.875 lb ai/A) = 0.000194 μg/g 2. From Non
- Foliar Transfer Coefficient Table: http://epa.gov/pesticides/science/exposac

- policy

- 3
- march2013.pdf 3. Daily Dose (mg/kg/day) = [D B R x Transfer Coefficient x Conv. Factor (0.001 mg/μg) x 8 hr/day] / Body Weight (80 kg). 4: Short

- & Intermediate

- term Margin of Exposure (MOE) = Short

- term Dermal NOAEL ( 30 0 mg/kg/day) / Daily Dose (mg/kg/day). 

### For use on turf, the exposure/risk assessment for the proposed use s results in a post

- application occupational MOE of 9,00 0 , which is above the dermal LOC ( MOE ≥1 00 ) ; and therefore is not of concern.

### Page **50** of **59**

**Table 6.2**  **. 5.**  **Exposure and Risk Assessment for Occupational Post -**  **Application Activities on Turf.**  **Application Rate (lb**  **ai/A) Dermal Transfer Coefficient** 

**(cm 2**  **/hr) & Activities 1**  **Post Application**  **Day (t) Turf** 

**Transferable Residue**  **(TTR) 2**  **(μg/cm 2**  **) Daily Dose**  **3**

**(m g/k** **g/day) Short**  **- &** 

**Intermediate**

**- Term**  **Dermal MOE**  **4** 0.446 6,700 (Maintenance,

Transplanting/Planting, & Harvesting Sod) 0 0. 0 5 0.03 35 9,000
1 The transfer coefficient is the arithmetic mean value taken from MRID 46734001. It should be noted that a previous study on golf course maintenance (MRID 45530101) had been submitted, but had been determined to be unacceptable. Data from MRID 46734001 are believed to be more appropriate. 2 TTR derived as follows: 0
. 446 lb ai/A x 4.5 4E+8 μg/lb x 2.47E

- 8 A/cm2 x 0.01 (fraction of transferable ai) = 0. 0 5 μg/cm2

. 3 Daily Dose = [TTR (μg/cm2 ) x (0.001 mg/μg) x Dermal Transfer Coefficient x Exposure Time (8 hr)] / [Body Weight ( 80 kg)] = 0.0335 mg/kg/day

. 4 MOE = LOAEL/Daily Dose. Short

- /Intermediate

- Term LOAEL = 300 mg/kg/day. 

### Restricted Entry

Interval Since post

- application risk estimate s were not a concern on day 0 (12 hours following application), the REI is based on the acute toxicity of fluopy ram technical material. Fluop yr am is classified as T oxicity C ategory III b y the acute dermal route of exposure and Toxicity Category IV for acute ey e irritation potential and skin irritation potential. Under the WPS for Agricultural Pesticides, active ingredients classified as acute toxi city categories III or IV for these routes are assigned a 12

- hour REI. Therefore, the 12

- hour REI that appears on the proposed label s is adequate to protect agricultural workers from post

- application exposures to fluopy ram . **Seed Treatment Use on Peanut**  **S eeds**  With regard to seed treatment, the potential for post

- application exposures following the planting of fluopy ram - treated seeds is unlikely because s ustained levels of contact with treated seed after it has been placed in the soil or other planting medi a would not be expected because no routine cultural practice required for the production of agricultural commodities involves such an activity , as defined in the no/low contact criteria in the Worker Protection Standard (WPS) in 40 CFR §170.112
. Therefore , no quantitative post - application assessment is required for exposure to treated seeds that have already been planted

.

### Page **51** of **59**

**Appendix A. Summary of Occupational and Residential**  **Non -**  **cancer Algorithms**  **Occupational Handler**  **Non -**  **Cancer Algorithms**  Potential daily

exposures for occupational handlers are calculated using the following formulas:

E=UE * AR * A * 0.001 mg/ug where: E = e xposure (mg ai/day), UE = unit e xposure (μ g ai/lb ai), AR = m aximum application rate according to proposed label (lb ai A or lb ai/gal ), and A = area treated or amount handled (e.g., A/day , gal/day)

. The daily doses are calculated using the following formula: ADD= E * AF BW where: ADD = average dail y dose a bsorbed in a given scenario (mg ai/kg/ day), E = e xposure (mg ai/day), AF = absorption factor (dermal and/or inhalation), and BW = body

weight (kg)

. Margin of Exposure: Non
- cancer risk estimates for each application handler scenario are calculated using a Margin of Exposure (MOE), which is a ratio of the toxicological endpoint to the daily dose of concern. The daily dermal and inhalation dose received by occupational h andlers are compared to the appropriate POD ( i.e. , NOAEL) to assess the risk to occupational handlers for each exposure route. All MOE values are calculated using the following formula: MOE= POD ADD where: MOE = m argin of e xposure: value used by HED to represent risk estimates (unitless), POD = p oint of d eparture (mg/kg/day) , and ADD = average dail y dose absorbed in a given scenario (mg ai/kg/day)

. **Occupational Post -**  **application Algorithms** Exposure resulting from contacting previousl y treated turf while working is calculated as follows:

### Page **52** of **59** E = TTRt * CF1 * TC * ET where : E = exposure (mg/day); TTRt 

### = turf transferable residue on day "t" (μg/cm2 

### ); CF1 = weight unit conversion factor (0.001 mg/μg); TC = transfer coefficient (cm2 

### /hr); and ET = exposure time (hr/day). and TTRt = AR * F * (1

-FD) t 

### * CF2 * CF3 where: TTRt = turf transferable residue on day t (μg/cm 2 

### ); AR = application rate (lbs ai/ft2 

### or lb ai/acre); F = fraction of ai as transferable residue following application (unitless); FD = fraction of residue that dissipates daily (unitless); t = post - application day

on which exposure is being assessed; CF2 = weight unit conversion factor (4.54 x 10 8 

### μg/lb); and CF3 = area unit conversion factor (1.08 x 10 - 3 

### ft2 

### / cm2 

### or 2.47 x 10 - 8 

### acre/c m 2 

### ). Absorbed dose, normalized to body weight, is calculated as:

BW AF E D *  

### where : D = dose (mg/kg

- day); E = exposure (mg/day); AF = absorption factor (dermal); and BW = body

weight (kg).
**Residential Post -**  **application Algorithms** Post
- application Dermal Exposure Algorithm

– Phy sical Activities on Turf Exposure resulting from contacting previousl y treated turf while performing phys ical activities is calculated as shown below. Residential post

- application exposure assessment must in clude calculation of exposure on the day of application. Therefore, though an assessment can present exposures for any day “t” following the application, it must include “day 0” exposure. E = TTRt * CF1 * TC * ET

### Page **53** of **59**

where: E = exposure (mg/day); TTRt = turf transferable residue on day t (μg/cm 2 

### ); CF1 = weight unit conversion factor (0.001 mg/μg); TC = transfer coefficient (cm2 

### /hr); and ET = exposure time (hr/day). If chemical

- specific TTR data are available, then surface residues from the day of applicati on should be used (assume that individuals could be exposed to residues immediatel y after application). However, if data are not available, then TTR t 

### can be calculated using the following formula: TTR t 

### = AR * F * (1

-FD) t 

### * CF2 * CF3 where: TTRt = turf transferable residue on day t (μg/cm 2 

### ); AR = application rate (lbs ai/ft2 

### or lb ai/acre); F = fraction of ai as transferable residue following application (unitless); FD = fraction of residue that dissipates daily (unitless); t = post - application day

on which exposure is being assessed; CF2 = weight unit conversion factor (4.54 x 10 8 

### μg/lb); and CF3 = area unit conversion factor (1.08 x 10 - 3 

### ft2 

### / cm2 

### or 2.47 x 10 - 8 

### acre/cm2 

### ). Dermal absorbed doses are calculated as:
BW AF E D *  

### where: D = dose (mg/kg

- day); E = exposure (mg/day); AF = absorption factor (dermal); and BW = body

weight (kg). **Table A -**  **1 : Turf (Physical Activities)**  **-- Inputs for Residential Post**  **- application Dermal Exposure**  **Algorithm Notation**  **Exposure Factor (units)**  **Point Estimate(s)**  AR Application rate (mass active ingredient per unit area) 0.446 or 0.404 lb/A
F Fraction of AR as TTR

following application (if chemical

- specific data is unavailable) L/WP/WDG 0.01 Granules 0.002
F D Daily residue dissipation

(if chemical

- specific data is unavailable) L/WP/WDG 0.1 Granules 0.1

### Page **54** of **59**

**Table A -**  **1 : Turf (Physical Activities)**  **-- Inputs for Residential Post**  **- application Dermal Exposure**  **Algorithm Notation**  **Exposure Factor (units)**  **Point Estimate(s)**  (fraction)
TC Transfer

Coefficient (cm 2/hr) L/WP/WDG Adults 180,000 Children 1 < 2 years old 49,000 Granules Adults 200,000

Children 1 < 2 years old 54,000 ET Exposure Time

(hours per day) Adults 1.5 Children 1 < 2 years old 1.5 BW Body Weight (kg) Adults 80

Children 1 < 2 years old 11 L/WP/WDG = Liquids/Wettable Powders/Water

- dispersible Granules 

### Post
- application Hand

- to - Mouth Exposure Algorithm

– Physical Activities on Turf Exposure from hand

- to - mouth activity is calculated as follows (based on the algorithm utilized in the SHEDS
- Multimedia model ):

E = [HR * (

F M 

### * SA H 

### ) * (ET * N_Replen) * (1

- (1

- SE ) (Freq_HtM/N

-Replen) 

### )] where: E = exposure (mg/day); HR = hand residue loading (mg/cm2 

### ); FM = fraction hand surface area mouthed / event (fraction/event); SAH = ty pical surface area of one hand (cm 2 

### ); ET = exposure time (hr/day); N_Replen = number of replenishment intervals per hour (intervals/hour); SE = saliv a extraction factor (i.e., mouthing removal efficiency); and Freq_HtM = number of hand

- to - mouth contacts events per hour (events/hour). and

2 * SA DE * Fai HR H

hands 

###  

### where: HR = hand residue loading (mg/cm2 

### ); Fai hands 

### = fraction ai on hands compared to total surface residue from dermal transfer coefficient study (unitless); DE = dermal exposure (mg); and SAH 

### = ty pical surface area of one hand (cm2 

### ). Dose, normalized to body weight, is calculated as:

### Page **55** of **59** BW E D  

### where: D = dose (mg/kg

- day); E = exposure (mg/day); and BW = body

weight (kg). **Table A -**  **2 : Turf (Physical Activities)** 

**– Inputs for Residential Post**  **- application Hand**  **- to**  **- Mouth Exposure**  **Algorithm Notation**  **Exposure Factor (units)**  **Point Estimate(s)**

Fai hands Fraction of ai on hands

from dermal transfer coefficient study (unitless) Liquid formulations 0.06

Granular formulations 0.027 DE Dermal exposure (mg) Calculated SAH Ty

pical surface area of one hand (cm 2 ), children 1 < 2 years old 150 AR Application rate

(mass active ingredient per unit area) 0.404 lb/A HR Residue available on the hands (mg/cm2 ) Calculated via (DE * Fai hands )/SAH F M Fraction hand surface area mouthed (fraction/event) 0.127 N_Replen Replenishment intervals per hour (intervals/hr) 4 ET Exposure time (hrs/day) 1.5 SE Saliva extraction factor (unitless) 0.48 Freq_HtM Hand

- to - mo uth events per hour (events/hr) 13.9 BW Body

Weight (kg) Children 1 < 2 years old 11 

### Post
- application Object

- to - Mouth Exposure Algorithm

– Physical Activities on Turf Exposure from object

- to - mouth activity is calculated as follows (based on the algorithm utilized in SHEDS

- Multimedia):

E = [OR* CF1 * SAM O 

### * (ET * N_Replen) * (1

- (1

- SEO 

### ) (Freq_OtM/N_Replen)



### )] where: E = exposure (mg/day); OR = chemical residue loading on the object on day “t” (ug/cm2 

### ); CF1 = weight unit conversion factor (0.001 mg/μg); SAM O 

### = area of the object surface that is mouthed (cm2 

### /event); ET = exposure time (hr/day); N_Replen = number of replenishment intervals pe r hour (intervals/hour); SE O 

### = saliva extraction factor (i.e., mouthing removal efficiency); and

### Page **56** of **59**

Freq_OtM = number of object

- to - mouth contact events per hour (events/hour). and OR = AR * F O 

### * CF2 * CF3 where: OR = chemical residue loading on the object (μg/cm 2 

### ); AR = application rate (lbs ai/ft2 

### or lb ai/acre); F O 

### = fraction of residue available on the object (unitless); CF2 = weight unit conversion factor (4.54 x 10 8 

### μg/lb); and CF3 = area unit conversion factor (1.08 x 10 - 3 

### ft2 

### /cm2 

### or 2.47 x 10 - 8 

### acre/cm2 

### ). Dose, normalized to body weight, is calculated as:
BW E D  

### where: D = dose (mg/kg

- day); E = exposure (mg/day); and BW = body weight (kg). **Table A -**  **3 : Turf (Physical Activities)** 

**– Inputs for Residential Post**  **- application Object** **- to**  **- Mouth Exposure**  **Algorithm Notation**  **Exposure Factor (units)**  **Point Estimate(s)** AR Application rate (to turf)

(mass active ingredient per unit area) 0.404 lb/A F O Fraction of AR as OR following application 1 0.01 SAM O Surface area of object mouthed (cm 2/event) 10 N_Replen Replenishment intervals per hour (intervals/hour) 4 SE O Saliva extraction factor (fraction) 0.48 ET Exposure time (hours per day) 1.5 Freq_OtM Object

- to - mo uth events per hour (events/hr) 8.8 BW Body

Weight (kg) Children 1 < 2 years old 11 1 This SOP assumes that all of the residue on the turf could be transferred to the object (e.g., object residue is equal to turf transferable residue). 

### Post
- application Incidental Soil Ingestion Exposure Algorithm

– Phy sical Activities on Turf Exposure from incidental soil ingestion is calculated as follows: E = SRt * SIgR * CF1 where:

### Page **57** of **59**

E = exposure (mg/day); SRt = soil residue on day "t" (μg/g); SI gR = ingestion rate of soil (mg/day); and CF1 = weight unit conversion factor (1 x 10 - 6 

### g/μg). and SRt = AR * FS * (1

-F D 

### ) t 

### * CF2 * CF3 * CF4 where: SRt 

### = soil residue on day "t" (μg/g); AR = application rate (lbs ai/ft2 

### or lb ai/acre); FS = fraction of ai available in uppermost cm of soil (fraction/cm); F D 

### = fraction of residue that dissipates daily (unitless); T = post
- application day

on which exposure is being assessed; CF2 = weight unit conversion factor (4.54 x 10 8 

### μg/lb); CF3 = area un it conversion factor (1.08 x 10 - 3 

### ft2 

### /cm2 

### or 2.47 x 10 - 8 

### acre/cm2 

### ); and CF4 = soil volume to weight unit conversion factor (0.67 cm 3 

### /g soil). Dose, normalized to body weight, are calculated as:
BW E D  

### where : D = dose (mg/kg

- day); E = exposure (mg/day); and BW = body

weight (kg). **Table A -**  **4 : Turf (Physical Activities)** 

**– Inputs for Residential Post**  **- application Incidental Soil Ingestion**  **Exposure Algorithm**  **Notation Exposure Factor**  **(units) Point Estimate(s)**  AR Application rate

(mass active ingredient per unit area) 0.404 lb/A FS Fraction of AR available in uppermost 1 cm of soil (unitless) 1 F D Daily residue dissipation (fraction) 0.1 SIgR Soil ingestion rate (mg/day) 50 BW Body

w eight (kg) Children 1 < 2 years old 11


### Post
- application Dermal Exposure Algorithm

– Mowing Exposure resulting from contacting previousl y treated turf while mowing is calculated as follows:

### Page **58** of **59** E = TTRt * CF1 * TC * ET where : E = exposure (mg/day); TTRt 

### = turf transferable residue on day "t" (μg/cm 2 

### ); CF1 = weight unit conversion factor (0.001 mg/μg); TC = transfer coefficient (cm2 

### /hr); and ET = exposure time (hr/day). and TTRt = AR * F AR 

### * (1

-F

D 

### ) t 

### * CF2 * CF3 where : TTRt 

### = turf transferable residue on day "t" (μg/cm2 

### ); AR = application rate (lbs ai/ft2 

### or lb ai/acre); F AR 

### = fraction of ai retained on turf (unitless); F D 

### = fraction of residue that dissipates daily (unitless); t = post - application day

on which exposure is being assessed; CF2= weight unit conversion factor (4.54 x 10 8 

### μg/lb); and CF3 = area unit conversion factor (1.08 x 10 - 3 

### ft2 

### /cm2 

### or 2.47 x 10 - 8 

### acre/cm2 

### ). Absorbed dose, normalized to body weight, are calculated as:

BW AF E D *  

### where : D = dose (mg/kg

- day); E = exposure (mg/day); AF = absorption factor (dermal); and BW = body

weight (kg). **Table A -**  **5 : Turf (Mowing)** 

**– Inputs for Residential Post**  **- application Dermal Exposure**  **Algorithm Notation**  **Exposure Factor (units)**  **Point Estimate(s)** AR Application rate mass active ingredient per unit area 0.446 lb/A
F AR Fraction of AR as TTR following application L/WP/WDG 0.01 Granules 0.002
F D Daily residue dissipation L/WP/WDG 0.1 Granules 0.1 TC Transfer Coefficient Adult 5,500

### Page **59** of **59**

**Table A -**  **5 : Turf (Mowing)** 

**– Inputs for Residential Post**  **- application Dermal Exposure**  (cm 2/hr) Children 11 < 16 years

old 4,500 ET Exposure time (hours per day) 1 BW Body Weight (kg) Adults 80

Children 11 < 16 years old 57 L/WP/WDG = liquid/wettable powder/water dispersible granule