# Patent

## Title
Active ingredient combinations comprising pyridylethylbenzamides and other active ingredients

## Abstract

The present invention relates to novel active ingredient combinations which consist of fluopyram and other known active ingredients and are very well suited for the control of animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in the treatment of seeds, and are also suitable for increasing yields.

## Background
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a §371 National Stage Application of PCT/EP2011/071418, filed Nov. 30, 2011, which claims priority to European Application No. 10193335.6, filed Dec. 1, 2010; and U.S. Provisional Application No. 61/419,438, filed Dec. 3, 2010.


BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates to new active ingredient combinations which consist of fluopyram and other known active ingredients and which are very well suited to the control of animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in seed treatment, and also to the boosting of yields.
Description of Related Art
It is already known that certain pyridylethylbenzamides possess fungicidal, insecticidal, and acaricidal and nematicidal properties.
WO 2004/016088 describes pyridylethylbenzamides and their use as fungacides. The possibility of combining one or more of the disclosed pyridylethylbenzamide derivatives with other known fungicides, insecticides, nematicides or acaricides for the purpose of broadening the spectrum of activity is likewise described. The application, however, teaches neither which insecticidal mixing partners are suitable, nor the mixing ratio in which insecticides and pyridylethylbenzamide derivatives are combined with one another. WO 2005/077901 teaches fungicidal compositions comprising at least one pyridylethylbenzamide, a fungicide and an inhibitor of electron transport in the respiratory chain of fungi. The patent application, however, does not mention any mixtures of pyridylethylbenzamides with insecticides. WO 2008/003738 teaches fungicidal compositions comprising at least one pyridylethylbenzamide and an insecticide. A possible nematicidal action of the compositions is described in the application, but not explicitly for mixtures comprising N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide.
The activity of the active ingredients and active ingredient compositions described in the prior art is good, but is capable of improvement at low application rates in certain cases, especially in the context of nematode control.
SUMMARY
The object on which the present invention is based, therefore, is that of providing nematicidal, insecticidal and acaricidal active ingredient combinations having improved activity, especially with regard to nematodes.
It has now been found that active ingredient combinations comprising

    (1-1) N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide of formula (I)






(fluopyram)

    
    
        and also its N-oxides;

and

    
    
    (II) at least one further active ingredient selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (SerenadeTM) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (BioactTM) (II-6), azadirachtin (II-7), thymol (II-8), Metarhizium anisopliae (II-9), Rhizobium spp. (II-10), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Bacillus amyloliquefaciens strain FZB 42 (II-19), Myrothecium verrucaria strain AARC-0255 (II-20), pyrethrum (II-21), Cydia pomonella granulosis virus (CpGV) (II-22), Metarhizium anisopliae strain F52 (11-23), arbuscular mycorrhiza fungus (II-24), Beauveria bassiana strain ATCC 74040 (II-25), Beauveria brongniartii (II-26), Lecanicillium lecanii (also known as Verticillium lecanii) (II-27), Bacillus thuringiensis subsp. tenebrionis (II-28)

are very well suited to the control of phytopathogenic fungi and animal pests, more particularly nematodes, in foliar and soil application, particularly in the context of seed treatment, and also to the boosting of yields.



The insecticides or active nematicidal ingredients of group (II) are selected from the group consisting of the following:
fluensulfone (II-1) known from WO-A 2001/002378
and/or
imicyafos (II-2) known from EP-A 0464830
and/or
Bacillus subtilis (II-3)
and/or
Bacillus subtilis strain QST 713 (II-4)
and/or
Paecilomyces lilacinus (II-5)
and/or
Paecilomyces lilacinus strain 251 (II-6)
and/or
azadirachtin (Cas-No 11141-17-6) (II-7)
and/or
Thymol (II-8)
and/or
Metarhizium anisopliae (II-9),
and/or
Rhizobium spp. (II-10),
and/or
Beauveria spp. (II-11),
and/or
Verticillium spp (II-12)
and/or
Metschnikowia fructicola (II-13) known from Kurztman and Droby, System. Application Microbiol. (2001), 24, pp 395-399
and/or
Metschnikowia fructicola strain NRRL Y-30752, (II-14) known from U.S. Pat. No. 6,994,849
and/or
Bacillus subtilis strain GB03 (II-15) known under the name KodiakTM marketed by Gustafson LLC and/or
Bacillus pumilus strain GB34 known under the name YieldShieldTM marketed by Gustafson LLC
and/or
Bacillus pumilus strain QST2808 known under the name SonataTM marketed by Agraquest
and/or
Bacillus amyloliquefaciens strain IN937a
and/or
Myrothecium verrucaria strain AARC-0255 known under the name DiTeraTM marketed by Valent BioSciences
and/or
pyrethrum (II-21)
and/or
Cydia pomonella granulosis virus (CpGV) (II-22)
and/or
Metarhizium anisopliae strain F52 (II-23)
and/or
arbuscular mycorrhiza fungus (II-24)
and/or
Beauveria bassiana strain ATCC 74040 (known under the name Naturalis®) (II-25)
and/or
Beauveria brongniartii (II-26)
and/or
Lecanicillium lecanii (formerly known as Verticillium lecanii) (II-27)
and/or
Bacillus thuringiensis subsp. tenebrionis (11-28).


DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (SerenadeTM) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (BioactTM) (II-6), azadirachtin (II-7), thymol (II-8), Metarhizium anisopliae (II-9), Rhizobium spp. (II-10), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14).
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of bacteria consisting of Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (SerenadeTM) (II-4), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Rhizobium spp. (II-10), Bacillus thuringiensis subsp. tenebrionis (II-28).
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of Bacillus species consisting of Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (SerenadeTM) (II-4), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Bacillus thuringiensis subsp. tenebrionis (II-28).
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of fungal species consisting of Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (BioactTM) (II-6), Metarhizium anisopliae (II-9), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14), Myrothecium verrucaria strain AARC-0255 (II-19), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24), Beauveria bassiana, in particular strain ATCC 74040 (II-25), Beauveria brongniartii (II-26), Lecanicillium lecanii (formerly known as Verticillium lecanii) (II-27).
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (BioactTM) (II-6), Metarhizium anisopliae (II-9), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14), Bacillus subtilis strain GB03 (II-15), Bacillus amyloliquefaciens strain FZB 42 (II-19), Bacillus thuringiensis subsp. tenebrionis (II-28), pyrethrum (II-21), Cydia pomonella granulosis virus (CpGV) (II-22), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24).
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (SerenadeTM) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (BioactTM) (II-6) and also Metschnikowia fructicola (II-13).
In one particularly preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis strain QST 713 (SerenadeTM) (II-4), Paecilomyces lilacinus strain 251 (BioactTM) (II-6).
In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of the low molecular mass active ingredients fluensulfone (II-1), imicyafos (II-2), azadirachtin (II-7), thymol (II-8).
Surprisingly, the fungicidal, insecticidal and/or acaricidal and/or nematicidal action, more particularly the nematicidal action, of the active ingredient combinations of the invention, particularly after soil application, is substantially higher than the sum of the actions of the individual active ingredients. The effect is an unpredictable true synergistic effect, and not merely a supplementation of action. Moreover, the active ingredient combinations of the invention are suitable for effecting a boost to yield.
Preferred active ingredient combinations are those comprising the compounds of the formula (I-1) and at least one active ingredient of the formula (II).
Of particular interest are the following combinations:
(I-1)+(II-1), (I-1)+(II-2), (I-1)+(II-3), (I-1)+(II-4), (I-1)+(II-5), (I-1)+(II-6), (I-1)+(II-7), (I-1)+(II-8), (I-1)+(II-9), (I-1)+(II-10), (I-1)+(II-11), (I-1)+(II-12), (I-1)+(II-13), (I-1)+(II-14), (I-1)+(II-15), (I-1)+(II-16), (I-1)+(II-17), (I-1)+(II-18), (I-1)+(II-19), (I-1)+(II-20), (I-1)+(II-21), (1-1)+(II-22), (I-1)+(II-23), (I-1)+(II-24), (I-1)+(II-25), (I-1)+(II-26), (I-1)+(II-27), (I-1)+(II-28).
The active ingredient combinations may also, furthermore, comprise other, admix components with fungicidal, acaricidal, nematicidal or insecticidal activity.
If the active ingredients are present in particular weight ratios in the active ingredient combinations of the invention, the improved action is apparent with particular clarity. However, within the active ingredient combinations, the weight ratios of the active ingredients can be varied within a relatively wide range. In general the combinations of the invention comprise active ingredients of the formula (I-1) and the mixing partner in the preferred and particularly preferred mixing ratios indicated in the table below:














Preferred
Particularly 




mixing ratio
preferred mixing
Very particularly


Mixing
(I-1):Mixing
ratio (I-1):Mixing
preferred mixing ratio


partner
partner
partner
(I-1):Mixing partner







II-1
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-2
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-3
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-4
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-5
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-6
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-7
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-8
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-9
500:1 to 1:50000
125:1 to 1:12500
25:1 to 1:2500


II-10
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-11
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-12
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-13
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-14
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-15
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-16
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-17
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-18
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-19
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-20
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-21
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-22
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-23
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-24
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-25
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-26
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-27
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25


II-28
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25









Animal Pests

The active ingredient combinations combine good tolerance by plants with suitability for controlling animal pests, such as insects and/or arachnids, and more particularly nematodes, which are prevalent in viticulture, fruit growing, agriculture, horticulture, and forestry. They can be used with preference as crop protection compositions. They are active against normally sensitive species and resistant species, and also against all or individual development stages. The aforementioned pests include the following:
Insects
Examples from the order of the Anoplura (Phthiraptera): Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectes spp.
Examples from the class of the Arachnida: Acarus spp., Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Amphi tetranychus viennensis, Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Halotydeus destructor, Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Nuphersa spp., Oligonychus spp., Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates lycopersici. 
Examples from the class of the Bivalva: Dreissena spp.
Examples from the order of the Chilopoda: Geophilus spp., Scutigera spp.
Examples from the order of the Coleoptera: Acalymma vittatum, Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apion spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Cassida spp., Cerotoma trifurcata, Ceutorrhynchus spp., Chaetocnema spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Ctenicera spp., Curculio spp., Cryptorhynchus lapathi, Cylindrocopturus spp., Dermestes spp., Diabrotica spp., Dichocrocis spp., Diloboderus spp., Epilachna spp., Epitrix spp., Faustinus spp., Gibbium psylloides, Hellula undalis, Heteronychus arator, Heteronyx spp., Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Lema spp., Leptinotarsa decemlineata, Leucoptera spp., Lissorhoptrus oryzophilus, Lixus spp., Luperodes spp., Lyctus spp., Megascelis spp., Melanotus spp., Meligethes aeneus, Melolontha spp., Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Oryzaphagus oryzae, Otiorrhynchus spp., Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Phyllotreta spp., Popillia japonica, Premnotrypes spp., Psylliodes spp., Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp., Tanymecus spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.
Example from the order of the Collembola: Onychiurus armatus. 
Example from the order of the Diplopoda: Blaniulus guttulatus. 
Examples from the order of the Diptera: Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp., Asphondylia spp., Bactrocera spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chironomus spp., Chrysomyia spp., Cochliomyia spp., Contarinia spp., Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dasyneura spp., Delia spp., Dermatobia hominis, Drosophila spp., Echinocnemus spp., Fannia spp., Gastrophilus spp., Hydrellia spp., Hylemyia spp., Hyppobosca spp., Hypoderma spp., Liriomyza spp. Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia spp., Phorbia spp., Prodiplosis spp., Psila rosae, Rhagoletis spp., Stomoxys spp., Tabanus spp., Tannia spp., Tetanops spp., Tipula spp.
Examples from the class of the Gastropoda: Anion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Pomacea spp., Succinea spp.
Examples from the class of the helminths: Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp, Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancrofti. 
It is also possible for protozoa, such as Eimeria, to be controlled.
Examples from the order of the Heteroptera: Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Monalonion atratum, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus spp., Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.
Examples from the order of the Homoptera: Acyrthosipon spp., Acrogonia spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Diaphorina spp., Diaspis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Ferrisia spp., Geococcus coffeae, Hieroglyphus spp., Homalodisca coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva spp., Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides Manus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes spp., Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.
Examples from the order of the Hymenoptera: Athalia spp., Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.
Examples from the order of the Isopoda: Armadillidium vulgare, Oniscus asellus, Porcellio scaber. 
Examples from the order of the Isoptera: Acromyrmex spp., Atta spp., Cornitermes cumulans, Microtermes obesi, Odontotermes spp., Reticulitermes spp.
Examples from the order of the Lepidoptera: Acronicta major, Adoxophyes spp., Aedia leucomelas, Agrotis spp., Alabama spp., Amyelois transitella, Anarsia spp., Anticarsia spp., Argyroploce spp., Barathra brassicae, Borbo cinnara, Bucculatrix thurberiella, Bupalus piniarius, Busseola spp., Cacoecia spp., Caloptilia theivora, Capua reticulana, Carpocapsa pomonella, Carposina niponensis, Chematobia brumata, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocerus spp., Cnephasia spp., Conopomorpha spp., Conotrachelus spp., Copitarsia spp., Cydia spp., Dalaca noctuides, Diaphania spp., Diatraea saccharalis, Earias spp., Ecdytolopha aurantium, Elasmopalpus lignosellus, Eldana saccharina, Ephestia kuehniella, Epinotia spp., Epiphyas postvittana, Etiella spp., Eulia spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Feltia spp., Galleria mellonella, Gracillaria spp., Grapholitha spp., Hedylepta spp., Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homoeosoma spp., Homona spp., Hyponomeuta padella, Kakivoria flavofasciata, Laphygma spp., Laspeyresia molesta, Leucinodes orbonalis, Leucoptera spp., Lithocolletis spp., Lithophane antennata, Lobesia spp., Loxagrotis albicosta, Lymantriai spp., Lyonetia spp., Malacosoma neustria, Maruca testulalis, Mamestra brassicae, Mocis spp., Mythimna separata, Nymphula spp., Oiketicus spp., Oria spp., Orthaga spp., Ostrinia spp., Oulema oryzae, Panolis flammea, Parnara spp., Pectinophora spp., Perileucoptera spp., Phthorimaea spp., Phyllocnistis citrella, Phyllonorycter spp., Pieris spp., Platynota stultana, Plusia spp., Plutella xylostella, Prays spp., Prodenia spp., Protoparce spp., Pseudaletia spp., Pseudoplusia includens, Pyrausta nubilalis, Rachiplusia nu, Schoenobius spp., Scirpophaga spp., Scotia segetum, Sesamia spp., Sparganothis spp., Spodoptera spp., Stathmopoda spp., Stomopteryx subsecivella, Synanthedon spp., Tecia solanivora, Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix spp., Trichoplusia spp., Tuta absoluta, Virachola spp.
Examples from the order of the Orthoptera: Acheta domesticus, Blatta orientalis, Blattella germanica, Dichroplus spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana, Schistocerca gregaria. 
Examples from the order of Siphonaptera: Ceratophyllus spp., Xenopsylla cheopis. 
Example from the order of the Symphyla: Scutigerella spp.
Examples from the order of the Thysanoptera: Anaphothrips obscurus, Baliothrips biformis, Drepanothris reuteri, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips spp.
Example from the order of the Thysanura: Lepisma saccharina. 
Nematodes
All species of plant-parasitic nematodes may in principle be controlled using the active ingredient combinations of the invention. The active ingredient combinations of the invention prove particularly advantageous in the control of nematodes selected from the group consisting of the following: Aglenchus agricola, Anguina tritici, Aphelenchoides arachidis, Aphelenchoides fragariae, Belonolaimus gracilis, Belonolaimus longicaudatus, Belonolaimus nortoni, Cacopaurus pestis, Criconemella curvata, Criconemella onoensis, Criconemella ornata, Criconemella rusium, Criconemella xenoplax (=Mesocriconema xenoplax) and Criconemella spp. in general, Criconemoides ferniae, Criconemoides onoense, Criconemoides ornatum and Criconemoides spp. in general, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and Ditylenchus spp. in general, Dolichodorus heterocephalus, Globodera pallida (=Heterodera pallida), Globodera rostochiensis, Globodera solanacearum, Globodera tabacum, Globodera virginiae, Helicotylenchus digonicus, Helicotylenchus dihystera, Helicotylenchus erythrine, Helicotylenchus multicinctus, Helicotylenchus nannus, Helicotylenchus pseudorobustus and Helicotylenchus spp. in general, Hemicriconemoides, Hemicycliophora arenaria, Hemicycliophora nudata, Hemicycliophora parvana, Heterodera avenae, Heterodera cruciferae, Heterodera glycines, Heterodera oryzae, Heterodera schachtii, Heterodera zeae and Heterodera spp. in general, Hoplolaimus aegyptii, Hoplolaimus californicus, Hoplolaimus columbus, Hoplolaimus galeatus, Hoplolaimus indicus, Hoplolaimus magnistylus, Hoplolaimus pararobustus, Longidorus africanus, Longidorus breviannulatus, Longidorus elongatus, Longidorus laevicapitatus, Longidorus vineacola and Longidorus spp. in general, Meloidogyne acronea, Meloidogyne africana, Meloidogyne arenaria, Meloidogyne arenaria thamesi, Meloidogyne artiella, Meloidogyne chitwoodi, Meloidogyne coffeicola, Meloidogyne ethiopica, Meloidogyne exigua, Meloidogyne graminicola, Meloidogyne graminis, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne incognita acrita, Meloidogyne javanica, Meloidogyne kikuyensis, Meloidogyne naasi, Meloidogyne paranaensis, Meloidogyne thamesi and Meloidogyne spp. in general, Meloinema spp., Nacobbus aberrans, Neotylenchus vigissi, Paraphelenchus pseudoparietinus, Paratrichodorus allius, Paratrichodorus lobatus, Paratrichodorus minor, Paratrichodorus nanus, Paratrichodorus porosus, Paratrichodorus teres and Paratrichodorus spp. in general, Paratylenchus hamatus, Paratylenchus minutus, Paratylenchus projectus and Paratylenchus spp. in general, Pratylenchus agilis, Pratylenchus alleni, Pratylenchus andinus, Pratylenchus brachyurus, Pratylenchus cerealis, Pratylenchus coffeae, Pratylenchus crenatus, Pratylenchus delattrei, Pratylenchus giibbicaudatus, Pratylenchus goodeyi, Pratylenchus hamatus, Pratylenchus hexincisus, Pratylenchus loosi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus pratensis, Pratylenchus scribneri, Pratylenchus teres, Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus zeae and Pratylenchus spp. in general, Pseudohalenchus minutus, Psilenchus magnidens, Psilenchus tumidus, Punctodera chalcoensis, Quinisulcius acutus, Radopholus citrophilus, Radopholus similis, Rotylenchulus borealis, Rotylenchulus parvus, Rotylenchulus reniformis and Rotylenchulus spp. in general, Rotylenchus laurentinus, Rotylenchus macrodoratus, Rotylenchus robustus, Rotylenchus uniformis and Rotylenchus spp. in general, Scutellonema brachyurum, Scutellonema bradys, Scutellonema clathricaudatum and Scutellonema spp. in general, Subanguina radiciola, Tetylenchus nicotianae, Trichodorus cylindricus, Trichodorus minor, Trichodorus primitivus, Trichodorus proximus, Trichodorus similis, Trichodorus sparsus and Trichodorus spp. in general, Tylenchorhynchus agri, Tylenchorhynchus brassicae, Tylenchorhynchus clarus, Tylenchorhynchus claytoni, Tylenchorhynchus digitatus, Tylenchorhynchus ebriensis, Tylenchorhynchus maximus, Tylenchorhynchus nudus, Tylenchorhynchus vulgaris and Tylenchorhynchus spp. in general, Tylenchulus semipenetrans, Xiphinema americanum, Xiphinema brevicolle, Xiphinema dimorphicaudatum, Xiphinema index and Xiphinema spp. in general.
The active ingredient combinations of the invention prove especially advantageous in the control of nematodes selected from the group consisting of the following: Meloidogyne spp., such as Meloidogyne incognita, Meloidogyne javanica, Meloidogyne hapla, Meloidogyne arenaria; Ditylenchus ssp., such as Ditylenchus dipsaci, Ditylelenchus destructor; Pratylenchus ssp., such as Pratylenchus penetrans, Pratylenchus fallax, Pratylenchus coffeae, Pratylenchus loosi, Pratylenchus vulnus; Globodera spp., such as Globodera rostochiensis, Globodera pallida etc.; Heterodera spp., such as Heterodera glycines Heterodera shachtoii etc.; Aphelenchoides spp., such as Aphelenchoides besseyi, Aphelenchoides ritzemabosi, Aphelenchoides fragarieae; Aphelenchus ssp., such as Aphelenchus avenae; Radopholus ssp, such as Radopholus similis; Tylenchulus ssp., such as Tylenchulus semipenetrans; Rotylenchulus ssp., such as Rotylenchulus reniformis; 
Bursaphelenchus spp., such as Bursaphelenchus xylophilus, Aphelenchoides spp., Longidorus spp., Xiphinema spp., Trichodorus spp.
Furthermore, the active ingredient combinations of the invention prove active in the control of nematodes which infect humans or animals, such as round worm, pin worm, filaria, Wuchereri bancrofti, thread worms (convoluted filaria), Gnathostoma etc.
Animal Health
The active ingredient combinations of the invention do not act only against plant, hygiene and stored-product pests but also in the veterinary sector, against animal parasites (ecto- and endoparasites) such as hard ticks, soft ticks, mange mites, leaf mites, flies (biting and licking), parasitic fly larvae, lice, hair lice, feather lice, and fleas. These parasites including the following:
Examples from the order of the Anoplurida: Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp.
Examples from the order of the Mallophagida and the suborders Amblycerina and Ischnocerina: Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp.
Examples from the order Diptera and the suborders Nematocerina and Brachycerina: Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp., Melophagus spp.
Examples from the order of the Siphonapterida: Pulex spp., Ctenocephalides spp., Xenopsylla spp., Ceratophyllus spp.
Examples from the order of the Heteropterida: Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp.
Examples from the order of the Blattarida: Blatta orientalis, Periplaneta americana, Blattela germanica, Supella spp.
Examples from the subclass of the Acari (Acarina) and from the orders of the Meta- and Mesostigmata: Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp., Haemophysalis spp., Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp., Varroa spp.
Examples from the order of the Actinedida (Prostigmata) and Acaridida (Astigmata): Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp., Laminosioptes spp.
The active ingredient combinations of the invention are also suitable in the control of arthropods which infest agricultural livestock, such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffalos, rabbits, chickens, turkeys, ducks, geese and bees, for example, other domesticated animals such as dogs, cats, caged birds and aquarium fish, for example, and also so-called experimentation animals, such as hamsters, guinea pigs, rats and mice, for example. The aim of controlling these arthropods is to reduce fatalities and yield reductions (of meat, milk, wool, hides, eggs, honey, etc.), so that more economic and easier animal husbandry is possible through the use of the active ingredient combinations of the invention.
Application of the active ingredient combinations of the invention in the veterinary sector and in animal husbandry is, in a conventional way, through enteral administration in the form of, for example, tablets, capsules, potions, drenches, granules, pastes, boluses, the feed-through method, and suppositories, and by parenteral administration, as for example through injections (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.), implants, by nasal administration, by dermal application in the form, for example, of bathing or dipping, spraying, pour-on and spot-on, washing, and powdering, and also with the aid of molded articles containing active ingredient, such as collars, ear marks, tail marks, limb bands, halters, marking devices, etc.
In the context of application for livestock, poultry, domestic animals, etc., the active ingredient combinations may be applied as formulations (for example, powders, emulsions, flowable compositions) which comprise the active ingredients in an amount from 1 to 80 wt. %, directly or after 100- to 10 000-fold dilution, or may be used in the form of a chemical bath.
Crops
The crops to be protected, which have only been described in a general manner, are differentiated and specified below. Thus, with regard to use, vegetables are understood to mean, for example, fruit vegetables and flower-heads as vegetables, for example carrots, bell peppers, chilli peppers, tomatoes, aubergines, cucumbers, cucurbits, courgettes, broad beans, runner beans, bush beans, peas, artichokes, maize;
but also leafy vegetables, for example lettuce, chicory, endives, cress, rocket salad, field salad, iceberg lettuce, leek, spinach, swiss chard;
additionally tuber vegetables, root vegetables and stem vegetables, for example celeriac, beetroot, carrots, garden radish, horseradish, salsify, asparagus, table beet, palm shoots, bamboo shoots, and also bulb vegetables, for example onions, leek, fennel, garlic;

additionally brassica vegetables, such as cauliflower, broccoli, kohlrabi, red cabbage, white cabbage, green cabbage, savoy cabbage, brussels sprouts, chinese cabbage.

With regard to use, perennial crops are understood to mean citrus fruit, for example oranges, grapefruit, mandarins, lemons, limes, bitter oranges, kumquats, satsumas;
but also pome fruit, for example apples, pears and quince, and stone fruit, for example peaches, nectarines, cherries, plums, common plums, apricots;
additionally grapevine, hops, olives, tea, soya, oilseed rape, cotton, sugar cane, beet, potatoes, tobacco and tropical crops, for example mangoes, papayas, figs, pineapples, dates, bananas, durians, kakis, coconuts, cacao, coffee, avocados, lychees, maracujas, guavas,

and also almonds and nuts, for example hazelnuts, walnuts, pistachios, cashew nuts, brazil nuts, pecan nuts, butter nuts, chestnuts, hickory nuts, macadamia nuts, peanuts,

and additionally also soft fruit, for example blackcurrants, gooseberries, raspberries, blackberries, blueberries, strawberries, red bilberries, kiwis, cranberries.

With regard to use, ornamental plants are understood to mean annual and perennial plants, for example cut flowers, for example roses, carnations, gerbera, lilies, marguerites, chrysanthemums, tulips, daffodils, anemones, poppies, amaryllis, dahlias, azaleas, malves, but also, for example, bedding plants, potted plants and shrubs, for example roses, tagetes, pansies, geraniums, fuchsias, hibiscus, chrysanthemums, busy lizzies, cyclamen, african violets, sunflowers, begonias, in ornamental lawns, in golf lawns, but also in cereals such as barley, wheat, rye, triticale, oats, in rice, in millet, in maize, additionally, for example, bushes and conifers, for example fig trees, rhododendron, spruce trees, fir trees, pine trees, yew trees, juniper trees, stone pines, rose bays.
With regard to use, spices are understood to mean annual and perennial plants, for example aniseed, chilli pepper, bell pepper, pepper, vanilla, marjoram, thyme, cloves, juniper berries, cinnamon, tarragon, coriander, saffron, ginger.
The crops to be protected are highlighted in particular as follows: bell peppers, chilli peppers, tomatoes, aubergines, cucumbers, cucurbits, courgettes, artichokes, maize, celeriac, beetroot, carrots, garden radish, horseradish, salsifies, asparagus, table beet, palm shoots, bamboo shoots, onions, leek, oranges, grapefruit, mandarins, lemons, limes, bitter oranges, kumquats, satsumas, apples, pears, and quince, and stone fruit, such as, for example, peaches, nectarines, cherries, plums, common plums, apricots, grapevine, hops, soya, oilseed rape, cotton, sugar cane, beet, potatoes, tobacco, hazelnuts, walnuts, pistachios, cashew nuts, brazil nuts, pecan nuts, butter nuts, chestnuts, hickory nuts, macadamia nuts, peanuts, roses, carnations, gerbera, lilies, marguerites, chrysanthemums, tulips, daffodils, anemones, poppies, amaryllis, dahlias, azaleas, malves, barley, wheat, rye, triticale, oats, rice, millet, maize.
According to the invention, it is possible to treat all plants and plant parts. Plants are understood here to mean all plants and plant populations such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants may be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which can or cannot be protected by plant breeders' certificates.
GMOs
In a further preferred embodiment, transgenic plants and plant cultivars which have been obtained by genetic engineering methods, if appropriate in combination with conventional methods (Genetically Modified Organisms), and parts thereof are treated. The terms “parts” and “plant parts” have been explained above.
More preferably, plants of the plant cultivars which are in each case commercially available or in use are treated in accordance with the invention.
Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, nutrition), the treatment in accordance with the invention may also result in superadditive (“synergistic”) effects. For example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the substances and compositions which can be used in accordance with the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, better quality and/or higher nutritional value of the harvested products, better storage qualities and/or processability of the harvested products are possible which exceed the effects which were actually to be expected.
According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant varietal property or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering and genetic engineering methods. By plant parts are meant all above-ground and below-ground parts and organs of plants such as shoot, leaf, blossom and root, where for example leaves, needles, stems, branches, flowers, fruiting bodies, fruits and seed and also roots, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizones, runners and seeds, also belong to plant parts.
Among the plants that can be protected by the method according to the invention, mention may be made of major field crops such as maize, soya bean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugar beet, sugar cane, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pome fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, soft fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actimidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory—including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber—including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak Choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans—such as climbing beans and broad beans), Chenopodiaceae sp. (for instance Swiss chard, white cabbage spinach, beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; and also genetically modified homologs of these crops.
The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into the genome. The expression “heterologous gene” essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using, for example, antisense technology, cosuppression technology or RNA interference—RNAi—technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation event or transgenic event.
Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, nutrition), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage qualities and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.
At certain application rates, the active ingredient combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, also those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active ingredients.
Plants and plant cultivars which are preferably treated according to the invention include all plants which have genetic material which imparts particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).
Plants and plant cultivars which are also preferably treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.
For example, examples of nematode-resistant plants are described in U.S. patent application Ser. Nos. 11/765,491, 11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904, 11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947, 12/252,453, 12/209,354, 12/491,396 or 12/497,221.
Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, or shade avoidance.
Plants and plant cultivars which may also be treated according to the invention are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage qualities.
Examples of plants with the above-mentioned traits are non-exhaustively listed in table A.
Plants that may be treated according to the invention are hybrid plants that already express the characteristics of heterosis or hybrid vigor which results in generally higher yield and vigor, and improved health and resistance toward biotic and abiotic stresses. Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male-sterile plants and sold to growers. Male-sterile plants can sometimes (e.g. in maize) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or male flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seeds are the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have for example been described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male-sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation or by selection of plants containing a mutation imparting such herbicide tolerance.
Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), the genes encoding a petunia EPSPS (Shah et al., Science (1986), 233, 478-481), a tomato EPSPS (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289), or an eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described for example in EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Pat. Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/036782, WO 03/092360, WO 05/012515 and WO 07/024,782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer glyphosate tolerance are described in e.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610, 12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255, 11/943,801 or 12/362,774. Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g. U.S. patent application Ser. Nos. 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.
Other herbicide-resistant plants are for example plants that have been made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g. described in U.S. patent application Ser. No. 11/760,602. One such efficient detoxifying enzyme is for example an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.
Further herbicide-tolerant plants are also plants that have been made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). HPPD is an enzyme that catalyses the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585 and WO 99/24586. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate dehydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO 2007/103567 and WO 2008/150473.
Still further herbicide-resistant plants are plants that have been made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidine, pyrimidinyloxy(thio)benzoate and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxy acid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright, Weed Science (2002), 50, 700-712), but also, in U.S. Pat. Nos. 5,605,011, 5,378,824, 5,141,870 and 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO 2006/060634. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024,782 and U.S. patent application No. 61/288,958.
Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soya beans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599 or for sunflower in WO 01/065922.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.
An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

    1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, updated by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa or Cry3Bb or insecticidal portions thereof (e.g. EP-A 1999141 and WO 2007/107302), or such proteins encoded by synthetic genes as for example described in U.S. patent application Ser. No. 12/249,016; or
    2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environm. Microbiol. (2006), 71, 1765-1774) or the binary toxin made up of the Cry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
    3) a hybrid insecticidal protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g. the Cry1A.105 protein produced by corn event MON89034 (WO 2007/027777); or
    4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn events MON863 or MON88017, or the Cry3A protein in corn event MIR604; or
    5) an insecticidal secreted protein Bacillus thuringiensis or from Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at: http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or
    6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795) or
    7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
    8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT 102; or
    9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3 and Cry1A or Cry1F (U.S. patent application Nos 61/126,083 and 61/195,019), or the binary toxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
    10) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein).


Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.
An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described for example in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

    1) plants which contain a transgene capable of reducing the expression and/or the activity of the poly(ADP-ribose)polymerase (PARP) gene in the plant cells or plants as described in WO 00/04173, WO/2006/045633, EP 04077984.5 or EP 06009836.5;
    2) plants which contain a stress tolerance-enhancing transgene capable of reducing the expression and/or the activity of the PARG-encoding genes of the plants or plants cells, as described in e.g. WO 2004/090140;
    3) plants which contain a stress tolerance-enhancing transgene encoding a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphoribosyltransferase as described e.g. in EP 04077624.7, WO 2006/133827, PCT/EP07/002,433, EP 1999263 or WO 2007/107326.


Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage qualities of the harvested product and/or altered properties of specific constituents of the harvested product, such as:

    1) transgenic plants which synthesize a modified starch, which in its physical-chemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behavior, the gelling strength, the starch grain size and/or the starch grain morphology, is changed in comparison with the synthesized starch in wild type plant cells or plants, so that this modified starch is better suited for special applications. Such transgenic plants synthesizing a modified starch are disclosed, for example in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO 2005/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No. 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026 and WO 97/20936.
    2) Transgenic plants which synthesize non-starch carbohydrate polymers or which synthesize non-starch carbohydrate polymers with altered properties in comparison to wild type plants without genetic modification. Example are plants producing polyfructose, especially of the inulin and levan type, as disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460 and WO 99/24593, plants producing alpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, U.S. Pat. No. 6,284,479, U.S. Pat. No. 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422, and plants producing alternan, as disclosed in WO 00/47727, WO 00/73422, EP 06077301.7, U.S. Pat. No. 5,908,975 and EP 0728213.
    3) Transgenic plants which produce hyaluronan, as for example disclosed in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779 and WO 2005/012529.
    4) Transgenic plants or hybrid plants, such as onions with characteristics such as ‘high soluble solids content’, ‘low pungency’ (LP) and/or ‘long storage’ (LS), as described in U.S. patent application Ser. Nos. 12/020,360 and 61/054,026.


Plants or plant cultivars (that have been obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered fiber characteristics and include:

    a) plants, such as cotton plants, containing an altered form of cellulose synthase genes as described in WO 98/00549,
    b) plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO 2004/053219;
    c) plants, such as cotton plants, with increased expression of sucrose phosphate synthase as described in WO 01/17333;
    d) plants, such as cotton plants, with increased expression of sucrose synthase as described in WO 02/45485;
    e) plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, e.g. through downregulation of fiber-selective β-1,3-glucanase as described in WO 2005/017157, or as described in EP 08075514.3 or in U.S. patent application No. 61/128,938;
    f) plants, such as cotton plants, having fibers with altered reactivity, e.g. through the expression of N-acetylglucosamintransferase gene including nodC and chitin synthase genes as described in WO 2006/136351.


Plants or plant cultivars (that have been obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered oil characteristics and include:

    a) plants, such as oilseed rape plants, producing oil having a high oleic acid content as described e.g. in U.S. Pat. No. 5,969,169, U.S. Pat. No. 5,840,946 or U.S. Pat. No. 6,323,392 or U.S. Pat. No. 6,063,947;
    b) plants such as oilseed rape plants, producing oil having a low linolenic acid content as described in U.S. Pat. No. 6,270,828, U.S. Pat. No. 6,169,190 or U.S. Pat. No. 5,965,755.
    c) Plants such as oilseed rape plants, producing oil having a low level of saturated fatty acids as described e.g. in U.S. Pat. No. 5,434,283 or U.S. patent application Ser. No. 12/668,303.


Plants or plant cultivars (that have been obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in U.S. patent application No. 61/135,230, WO09/068,313 and WO10/006,732.
Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combinations of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA), whether such petitions are granted or are still pending. At any time this information is readily available from APHIS (4700 River Road, Riverdale, Md. 20737, USA), for instance on its interne site (URL http://www.aphis.usda.gov/brs/notreg.html). On the filing date of this application the petitions for non-regulated status that were pending with APHIS or granted by APHIS were those listed in table B which contains the following information:

    
    
        Petition: the identification number of the petition. Technical descriptions of the transformation events can be found in the individual petition documents which are obtainable from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are herein incorporated by reference.
        Extension of a petition: reference to a previous petition for which an extension is requested.
        Institution: the name of the entity submitting the petition.
        Regulated article: the plant species concerned.
        Transgenic phenotype: the trait conferred to the plants by the transformation event.
        Transformation event or line: the name of the event or events (sometimes also designated as line or lines) for which non-regulated status is requested.
        APHIS documents: various documents published by APHIS in relation to the petition and which can be requested from APHIS.
    
    


Additionally particularly useful plants containing single transformation events or a combination of transformation events are listed for example in the database from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://ceragmc.org/index.php?evidcode=&hstIDXCode=&gType=&AbbrCode=&atCode=&stCode=&coIDCode=&action=gm_crop_database&mode=Submit).
Further particular transgenic plants include plants containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in table C.
In one embodiment of the invention the plants A-1 to A-183 of table A, in total or in part, or propagation material of said plants, is treated or contacted with the active ingredient combinations of the invention, alone or in the form of compositions comprising an active ingredient combination.















Transgenic





No.
event
Company
Description
Crop







A-1
ASR368
Scotts Seeds
Glyphosate tolerance derived by inserting a modified 5-
Agrostis





enolpyruvylshikimate-3-phosphate synthase (EPSPS)
stolonifera





encoding gene from Agrobacterium tumefaciens, parent
Creeping





line B99061.
bentgrass


A-2
Asr-368

Glyphosate tolerance; US 2006-162007
bentgrass


A-3
H7-1
Monsanto
Glyphosate herbicide tolerant sugar beet produced by
Beta vulgaris




Company
inserting a gene encoding the enzyme 5-






enolypyruvylshikimate-3-phosphate synthase (EPSPS)






from the CP4 strain of Agrobacterium tumefaciens;






WO 2004-074492



A-4
T120-7
Bayer Crop-
Introduction of the PPT-acetyltransferase (PAT)
Beta vulgaris




Science
encoding gene from Streptomyces viridochromogenes,





(Aventis Crop-
an aerobic soil bacterium. PPT normally acts to inhibit





Science
glutamine synthetase, causing a fatal accumulation of





(AgrEvo))
ammonia. Acetylated PPT is inactive.



A-5
GTSB77
Novartis Seeds;
Glyphosate herbicide tolerant sugar beet produced by
Beta vulgaris




Monsanto
inserting a gene encoding the enzyme 5-
(sugar beet)




Company
enolypyruvylshikimate-3-phosphate synthase (EPSPS)






from the CP4 strain of Agrobacterium tumefaciens.



A-6
T227-1

Glyphosate tolerance; US 2004-117870
Beta vulgaris






sugar beet


A-7
23-18-17, 23- 
Monsanto
High laurate acid (12:0) and myristate acid (14:0) canola
Brassica



198
Company
produced by inserting a thioesterase encoding gene from
napus




(formerly
the California bay laurel (Umbellularia californica).
(Argentine




Calgene)

Canola)


A-8
45A37, 46A40
Pioneer Hi-Bred
High oleic acid and low linolenic acid canola produced
Brassica




International
through a combination of chemical mutagenesis to select
napus




Inc.
for a fatty acid desaturase mutant with elevated oleic
(Argentine





acid content, and traditional back-crossing to introduce
Canola)





the low linolenic acid trait.



A-9
46A12, 46A16
Pioneer Hi-Bred
Combination of chemical mutagenesis, to achieve the
Brassica




International
high oleic acid trait, and traditional breeding with
napus




Inc.
registered canola varieties.
(Argentine






Canola)


A-10
GT200
Monsanto
Glyphosate herbicide tolerant canola produced by
Brassica




Company
inserting genes encoding the enzymes 5-
napus





enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(Argentine





from the CP4 strain of Agrobacterium tumefaciens and
Canola)





glyphosate oxidase from Ochrobactrum anthropi.



A-11
GT73, RT73
Monsanto
Glyphosate herbicide tolerant canola produced by
Brassica




Company
inserting genes encoding the enzymes 5-
napus





enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(Argentine





from the CP4 strain of Agrobacterium tumefaciens and
Canola)





glyphosate oxidase from Ochrobactrum anthropi.



A-12
HCN10
Aventis
Introduction of the PPT-acetyltransferase (PAT)
Brassica




CropScience
encoding gene from Streptomyces viridochromogenes,
napus





an aerobic soil bacterium. PPT normally acts to inhibit
(Argentine





glutamine synthetase, causing a fatal accumulation of
Canola)





ammonia. Acetylated PPT is inactive.



A-13
HCN92
Bayer Crop-
Introduction of the PPT-acetyltransferase (PAT)
Brassica




Science
encoding gene from Streptomyces viridochromogenes,
napus




(Aventis Crop-
an aerobic soil bacterium. PPT normally acts to inhibit
(Argentine




Science
glutamine synthetase, causing a fatal accumulation of
Canola)




(AgrEvo))
ammonia. Acetylated PPT is inactive.



A-14
MS1, RF1 =>
Aventis
Male sterility, fertility restoration, pollination control
Brassica



PGS1
CropScience
system displaying glufosinate herbicide tolerance. MS
napus




(formerly Plant
lines contained the barnase gene from Bacillus
(Argentine




Genetic
amyloliquefaciens, RF lines contained the barstar gene
Canola)




Systems)
from the same bacterium, and both lines contained the






phosphinothricin N-acetyltransferase (PAT) encoding






gene from Streptomyces hygroscopicus.



A-15
MS1,
Aventis
Male sterility, fertility restoration, pollination control 
Brassica



RF2 => PGS2
CropScience
system displaying glufosinate herbicide tolerance. MS
napus




(formerly Plant
lines contained the barnase gene from Bacillus
(Argentine




Genetic
amyloliquefaciens, RF lines contained the barstar gene
Canola)




Systems)
from the same bacterium, and both lines contained the






phosphinothricin N-acetyltransferase (PAT) encoding






gene from Streptomyces hygroscopicus.



A-16
MS8 × RF3
Bayer
Male sterility, fertility restoration, pollination control
Brassica




CropScience
system displaying glufosinate herbicide tolerance. MS
napus




(Aventis
lines contained the barnase gene from Bacillus
(Argentine




CropScience
amyloliquefaciens, RF lines contained the barstar gene
Canola)




(AgrEvo))
from the same bacterium, and both lines contained the






phosphinothricin N-acetyltransferase (PAT) encoding






gene from Streptomyces hygroscopicus.



A-17
MS-B2

Male sterility, WO 01/31042
Brassica






napus






(Argentine






Canola)


A-18
MS-BN1/RF-

Male sterility/restoration; WO 01/41558
Brassica



BN1


napus






(Argentine






Canola)


A-19
NS738,
Pioneer Hi-Bred
Selection of somaclonal variants with altered
Brassica



NS1471,
International
acetolactate synthase (ALS) enzymes, following
napus



NS1473
Inc.
chemical mutagenesis. Two lines (P1, P2) were initially
(Argentine





selected with modifications at different unlinked loci.
Canola)





NS738 contains the P2 mutation only.



A-20
OXY-235
Aventis
Tolerance to the herbicides bromoxynil and ioxynil by
Brassica




CropScience
incorporation of the nitrilase gene from Klebsiella
napus




(formerly Rhône
pneumoniae.
(Argentine




Poulenc Inc.)

Canola)


A-21
PHY14,
Aventis
Male sterility was obtained via insertion of the barnase
Brassica



PHY35
CropScience
ribonuclease gene from Bacillus amyloliquefaciens;
napus




(formerly Plant
fertility restoration by insertion of the barstar RNase
(Argentine




Genetic
inhibitor; PPT resistance via PPT-acetyltransferase
Canola)




Systems)
(PAT) from Streptomyces hygroscopicus.



A-22
PHY36
Aventis
Male sterility was obtained via insertion of the barnase
Brassica




CropScience
ribonuclease gene from Bacillus amyloliquefaciens;
napus




(formerly Plant
fertility restoration by insertion of the barstar RNase
(Argentine




Genetic
inhibitor; PPT-acetyltransferase (PAT) from
Canola)




Systems)
Streptomyces hygroscopicus.



A-23
RT73

Glyphosate resistance; WO 02/36831
Brassica






napus






(Argentine






Canola)


A-24
T45 (HCN28)
Bayer Crop-
Introduction of the PPT-acetyltransferase (PAT)
Brassica




Science
encoding gene from Streptomyces viridochromogenes,
napus




(Aventis
an aerobic soil bacterium. PPT normally acts to inhibit
(Argentine




CropScience
glutamine synthetase, causing a fatal accumulation of
Canola)




(AgrEvo))
ammonia. Acetylated PPT is inactive.



A-25
HCR-1
Bayer Crop
Introduction of the glufosinate ammonium herbicide
Brassica




Science
tolerance trait from transgenic B. napus line T45. This
rapa




(Aventis
trait is imparted by the gene for phosphinothricin
(Polish




CropScience
acetyltransferase (PAT) from S. viridochromogenes.
Canola)




(AgrEvo))




A-26
ZSR500/502
Monsanto
Introduction of a modified 5-enol-pyruvylshikimate-3-
Brassica




Company
phosphate synthase (EPSPS) and a gene from
rapa





Achromobacter sp., that degrades glyphosate by
(Polish





conversion to aminomethylphosphonic acid (AMPA)
Canola)





and glyoxylate by interspecific crossing with GT73.



A-27
EE-1

Insect resistance (Cry1Ac); WO 2007/091277
aubergine


A-28
55-1/63-1
Cornell
Papaya ringspot virus (PRSV)-resistant papaya produced
Carica




University
by inserting the coat protein (CP)-encoding sequences
papaya





from this plant potyvirus.
(papaya)


A-29
RM3-3, RM3-
Bejo Zaden BV
Male sterility was obtained via insertion of the barnase
Cichorium



4, RM3-6

ribonuclease gene from Bacillus amyloliquefaciens; PPT
intybus





resistance was obtained via the bar gene from S.
(chicory)





hygroscopicus, which encodes the PAT enzyme.



A-30
A, B
Agritope Inc.
Reduced accumulation of 5-adenosylmethionine (SAM),
Cucumis





and consequently reduced ethylene synthesis, by
melo





introduction of the gene encoding 5-adenosylmethionine
(melon)





hydrolase.



A-31
CZW-3
Asgrow (USA);
Cucumber mosaic virus (CMV)-, zucchini yellows
Cucurbita




Seminis
mosaic virus (ZYMV)- and watermelon mosaic virus
pepo




Vegetable Inc.
(WMV) 2-resistant squash (Curcurbita pepo) produced
(squash)




(Canada)
by inserting the coat protein (CP)-encoding sequences






from each of these plant viruses into the host genome.



A-32
ZW20
Upjohn (USA);
Zucchini yellows mosaic (ZYMV)- and watermelon
Cucurbita




Seminis
mosaic virus (WMV) 2-resistant squash (Curcurbita
pepo




Vegetable Inc.
pepo) produced by inserting the coat protein
(squash)




(Canada)
(CP)-encoding sequences from each of these plant






potyviruses into the host genome.



A-33
66
Florigene Pty
Delayed senescence and sulfonylurea herbicide-tolerant
Dianthus




Ltd.
carnations produced by inserting a truncated copy of the 
caryo-





carnation aminocyclopropane cyclase (ACC) synthase
phyllus





encoding gene in order to suppress expression of the
(carnation)





endogenous unmodified gene, which is required for






normal ethylene biosynthesis. Tolerance to sulfonylurea






herbicides was obtained via the introduction of a






chlorosulfuron-tolerant version of the acetolactate






synthase (ALS)-encoding gene from tobacco.



A-34
4, 11, 15, 16
Florigene Pty
Modified color and sulfonylurea herbicide-tolerant
Dianthus




Ltd.
carnations produced by inserting two anthocyanin
caryo-





biosynthetic genes whose expression results in a
phyllus





violet/mauve coloration. Tolerance to sulfonylurea
(carnation)





herbicides was obtained via the introduction of a






chlorosulfuron-tolerant version of the acetolactate






synthase (ALS)-encoding gene from tobacco.



A-35
959A, 988A,
Florigene Pty
Introduction of two anthocyanin biosynthetic genes
Dianthus



1226A, 1351A,
Ltd.
which results in a violet/mauve coloration; introduction 
caryo-



1363A, 1400A

of a variant form of acetolactate synthase (ALS).
phyllus






(carnation)


A-36
3560.4.3.5

Glyphosate/ALS inhibitor-tolerance; WO 2008002872
Glycine max






L. (soya






bean)


A-37
A2704-12

Glufosinate tolerance; WO 2006/108674
Glycine max






L. (soya






bean)


A-38
A2704-12,
Aventis
Glufosinate ammonium herbicide-tolerant soya bean
Glycine max



A2704-21,
CropScience
produced by inserting a modified phosphinothricin
L.



A5547-35

acetyltransferase (PAT)-encoding gene from the soil
(soya bean)





bacterium Streptomyces viridochromogenes.



A-39
A5547-127
Bayer
Glufosinate ammonium herbicide-tolerant soya bean
Glycine max




CropScience
produced by inserting a modified phosphinothricin
L.




(Aventis
acetyltransferase (PAT)-encoding gene from the soil
(soya bean)




CropScience
bacterium Streptomyces viridochromogenes.





(AgrEvo))




A-40
A5547-35

Glufosinate tolerance; WO 2006/108675
Glycine max






L. (soya






bean)


A-41
DP-305423-1

High oleic acid content/ALS inhibitor tolerance;
Glycine max





WO 2008/054747
L. (soya






bean)


A-42
DP356043
Pioneer Hi-Bred
Soya bean event with two herbicide tolerance genes:
Glycine max




International
glyphosate N-acetyltransferase, which detoxifies
L.




Inc.
glyphosate, and a modified acetolactate synthase (A
(soya bean)


A-43
G94-1, G94-
DuPont Canada
High oleic acid soya bean produced by inserting a
Glycine max



19, G168
Agricultural
second copy of the fatty acid desaturase (GmFad2-1)
L.




Products
encoding gene from soya bean, which resulted in
(soya bean)





“silencing” of the endogenous host gene.



A-44
GTS 40-3-2
Monsanto
Glyphosate-tolerant soya bean variety produced by
Glycine max




Company
inserting a modified 5-enolpyruvylshikimate-3-
L.





phosphate synthase (EPSPS)-encoding gene from the
(soya bean)





soil bacterium Agrobacterium tumefaciens.



A-45
GU262
Bayer
Glufosinate ammonium herbicide-tolerant soya bean
Glycine max




CropScience
produced by inserting a modified phosphinothricin
L.




(Aventis
acetyltransferase (PAT)-encoding gene from the soil
(soya bean)




CropScience
bacterium Streptomyces viridochromogenes.





(AgrEvo))




A-46
MON87701

Insect resistance (Cry1Ac); WO 2009064652
Glycine max






L. (soya






bean)


A-47
MON87705

altered fatty acid levels (mid-oleic acid and low
Glycine max





saturated); WO 2010037016
L. (soya






bean)


A-48
MON87754

Increased oil content; WO 2010024976
Glycine max






L. (soya






bean)


A-49
MON87769

Stearidonic acid (SDA)-comprising oil;
Glycine max





WO 2009102873
L. (soya






bean)


A-50
MON89788
Monsanto
Glyphosate-tolerant soya bean variety produced by
Glycine max




Company
inserting a modified 5-enolpyruvylshikimate-3-
L.





phosphate synthase (EPSPS)-encoding aroA (epsps)
(soya bean)





gene from Agrobacterium tumefaciens CP4;






WO 2006130436



A-51
OT96-15
Agriculture &
Low linolenic acid soya bean produced through
Glycine max




Agri-Food
traditional cross-breeding to incorporate the novel trait
L.




Canada
from a naturally occurring fan1 gene mutant that was
(soya bean)





selected for low linolenic acid content.



A-52
W62, W98
Bayer
Glufosinate ammonium herbicide-tolerant soya bean
Glycine max




CropScience
produced by inserting a modified phosphinothricin
L.




(Aventis
acetyltransferase (PAT)-encoding gene from the soil
(soya bean)




CropScience
bacterium Streptomyces hygroscopicus.





(AgrEvo))




A-53
15985
Monsanto
Insect-resistant cotton derived by transformation of the
Gossypium




Company
DP50B parent variety, which contained event 531
hirsutum L.





(expressing Cry1Ac protein), with purified plasmid
(cotton)





DNA containing the cry2Ab- gene from B. thuringiensis






subsp. kurstaki.



A-54
1143-14A

Insect resistance (Cry1Ab); WO 2006/128569
Gossypium






hirsutum L.






(cotton)


A-55
1143-51B

Insect resistance (Cry1Ab); WO 2006/128570
Gossypium






hirsutum L.






(cotton)


A-56
19-51A
DuPont Canada
Introduction of a variant form of acetolactate synthase
Gossypium




Agricultural
(ALS).
hirsutum L.




Products

(cotton)


A-57
281-24-236
DOW
Insect-resistant cotton produced by inserting the cry1F
Gossypium




AgroSciences
gene from Bacillus thuringiensisvar. aizawai. The
hirsutum L.




LLC
PAT-encoding gene from Streptomyces
(cotton)





viridochromogenes was introduced as a selectable






marker.



A-58
3006-210-23
DOW
Insect-resistant cotton produced by inserting the cry1Ac
Gossypium




AgroSciences
gene from Bacillus thuringiensissubsp. kurstaki. The
hirsutum L.




LLC
PAT-encoding gene from Streptomyces
(cotton)





viridochromogenes was introduced as a selectable






marker.



A-59
31807/31808
Calgene Inc.
Insect-resistant bromoxynil herbicide-tolerant cotton
Gossypium





produced by inserting the cry1Ac gene from Bacillus
hirsutum L.





thuringiensis and a nitrilase-encoding gene from
(cotton)





Klebsiella pneumoniae.



A-60
BXN
Calgene Inc.
Bromoxynil herbicide-tolerant cotton produced by
Gossypium





inserting a nitrilase-encoding gene from Klebsiella
hirsutum L.





pneumoniae.
(cotton)


A-61
CE43-67B

Insect resistance (Cry1Ab); WO 2006/128573
Gossypium






hirsutum L.






(cotton)


A-62
CE44-69D

Insect resistance (Cry1Ab); WO 2006/128571
Gossypium






hirsutum L.






(cotton)


A-63
CE46-02A

Insect resistance (Cry1Ab); WO 2006/128572
Gossypium






hirsutum L.






(cotton)


A-64
Cot102

Insect resistance (Vip3A); US 2006-130175
Gossypium






hirsutum L.






(cotton)


A-65
COT102
Syngenta Seeds,
Insect-resistant cotton produced by inserting the
Gossypium




Inc.
vip3A(a) gene from Bacillus thuringiensis AB88. The
hirsutum L.





APH4-encoding gene from E. coli was introduced as a
(cotton)





selectable marker.



A-66
COT202

Insect resistance (VIP3A); US2009181399
Gossypium






hirsutum L.






(cotton)


A-67
Cot202

Insect resistance (VIP3); US 2007-067868
Gossypium






hirsutum L.






(cotton)


A-68
DAS-21Ø23-5 ×
DOW
WideStrike TM, a stacked insect-resistant cotton derived
Gossypium



DAS-24236-5
AgroSciences
from conventional cross-breeding of parental lines 3006-
hirsutum L.




LLC
210-23 (OECD identifier: DAS-21Ø23-5) and 281-24-
(cotton)





236 (OECD identifier: DAS-24236-5).



A-69
DAS-21Ø23-5 ×
DOW
Stacked insect-resistant and glyphosate-tolerant cotton
Gossypium



DAS-24236-
AgroSciences
derived from conventional cross-breeding of WideStrike
hirsutum L.



5 ×
LLC und
cotton (OECD identifier: DAS-21Ø23-5 x DAS-24236-
(cotton)



MON88913
Pioneer Hi-Bred
5) with MON88913, known as RoundupReady Flex





International
(OECD identifier: MON-88913-8).





Inc.




A-70
DAS-21Ø23-5 ×
DOW
WideStrike TM/Roundup Ready ® cotton, a stacked
Gossypium



DAS-24236-
AgroSciences
insect-resistant and glyphosate-tolerant cotton derived
hirsutum L.



5 × MON-
LLC
from conventional cross-breeding of WideStrike cotton
(cotton)



Ø1445-2

(OECD identifier: DAS-21Ø23-5 x DAS-24236-5) with






MON1445 (OECD identifier: MON-Ø1445-2).



A-71
EE-GH3

Glyphosate tolerance; WO 2007/017186
Gossypium






hirsutum L.






(cotton)


A-72
EE-GH5

Insect resistance (Cry1Ab); WO 2008/122406
Gossypium






hirsutum L.






(cotton)


A-73
EE-GH6

Insect resistance (cry2Ae); W02008151780
Gossypium






hirsutum L.





(cotton)



A-74
event
281-24-
Insect resistance (Cry1F); WO 2005/103266
Gossypium



236


hirsutum L.






(cotton)


A-75
event3006-

Insect resistance (Cry1Ac); WO 2005/103266
Gossypium



210-23


hirsutum L.






(cotton)


A-76
GBH614
Bayer
Glyphosate herbicide-tolerant cotton produced by
Gossypium




CropScience
inserting the 2MEPSPS gene into variety Coker312 by
hirsutum L.




(Aventis
Agrobacterium under the control of Ph4a748At and
(cotton)




CropScience
TpotpC.





(AgrEvo))




A-77
LLCotton25
Bayer
Glufosinate ammonium herbicide-tolerant cotton
Gossypium




CropScience
produced by inserting a modified phosphinothricin
hirsutum L.




(Aventis
acetyltransferase (PAT)-encoding gene from the soil
(cotton)




CropScience
bacterium Streptomyces hygroscopicus;





(AgrEvo))
WO 2003013224



A-78
LLCotton25 ×
Bayer
Stacked herbicide-tolerant and insect-resistant cotton
Gossypium



MON15985
CropScience
combining tolerance to glufosinate ammonium herbicide
hirsutum L.




(Aventis
from LLCotton25 (OECD identifier: ACS-GHØØ1-3)
(cotton)




CropScience
with resistance to insects from MON15985 (OECD





(AgrEvo))
identifier: MON-15985-7).



A-79
MON 15985

Insect resistance (Cry1A/Cry2Ab); US 2004-250317
Gossypium






hirsutum L.






(cotton)


A-80
MON1445/1698
Monsanto
Glyphosate herbicide-tolerant cotton produced by
Gossypium




Company
inserting a naturally glyphosate-tolerant form of the
hirsutum L.





enzyme 5-enolpyruvylshikimate-3-phosphate synthase
(cotton)





(EPSPS) from the CP4 strain of A. tumefaciens.



A-81
MON15985 ×
Monsanto
Stacked insect-resistant and glyphosate-tolerant cotton
Gossypium



MON88913
Company
produced by conventional cross-breeding of the parental
hirsutum L.





lines MON88913 (OECD identifier: MON-88913-8) and
(cotton)





15985 (OECD identifier: MON-15985-7). Glyphosate






tolerance is derived from line MON88913 which






contains two genes encoding the enzyme 5-






enolypyruvylshikimate-3-phosphate synthase (EPSPS)






from the CP4 strain of Agrobacterium tumefaciens.






Insect resistance is derived from the line MON15985






which was produced by transformation of the DP50B






parent variety, which contained event 531 (expressing






the Cry1Ac protein), with purified plasmid DNA






containing the cry2Ab gene from B. thuringiensis subsp.






kurstaki.



A-82
MON-15985-7 ×
Monsanto
Stacked insect-resistant and herbicide-tolerant cotton
Gossypium



MON-
Company
derived from conventional cross-breeding of the parental
hirsutum L.



Ø1445-2

lines 15985 (OECD identifier: MON-15985-7) and
(cotton)





MON-1445 (OECD identifier: MON-Ø1445-2).



A-83
MON531/757/
Monsanto
Insect-resistant cotton produced by inserting the cry1Ac
Gossypium



1076
Company
gene from Bacillus thuringiensis subsp. kurstaki HD-73
hirsutum L.





(B.t.k.).
(cotton)


A-84
MON88913
Monsanto
Glyphosate herbicide-tolerant cotton produced by
Gossypium




Company
inserting two genes encoding the enzyme 5-
hirsutum L.





enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(cotton)





from the CP4 strain of Agrobacterium tumefaciens; WO






2004/072235



A-85
MON-ØØ531-
Monsanto
Stacked insect-resistant and herbicide-tolerant cotton
Gossypium



6 × MON-
Company
derived from conventional cross-breeding of the parental 
hirsutum L.



Ø1445-2

lines MON531 (OECD identifier: MON-ØØ531-6) and
(cotton)





MON-1445 (OECD identifier: MON-Ø1445-2).



A-86
PV-GHGT07

Glyphosate tolerance; US 2004-148666
Gossypium



(1445)


hirsutum L.






(cotton)


A-87
T304-40

Insect resistance (Cry1Ab); WO2008/122406
Gossypium






hirsutum L.






(cotton)


A-88
T342-142

Insect resistance (Cry1Ab); WO 2006/128568
Gossypium






hirsutum L.






(cotton)


A-89
X81359
BASF Inc.
Tolerance to imidazolinone herbicides by selection of a
Helianthus





naturally occurring mutant.
annuus






(sunflower)


A-90
RH44
BASF Inc.
Selection for a mutagenized version of the enzyme
Lens





acetohydroxy acid synthase (AHAS), also known as
culinaris





acetolactate synthase (ALS) or acetolactate pyruvate
(lentil)





lyase.



A-91
FP967
University of
A variant form of acetolactate synthase (ALS) was
Linum




Saskatchewan,
obtained from a chlorosulfuron-tolerant line of A.
usitatis-




Crop Dev.
thaliana and used to transform flax.
simum




Centre

L. (flax,






linseed)


A-92
5345
Monsanto
Resistance to lepidopteran pests through the introduction
Lycoper-




Company
of the cry1Ac gene from Bacillus thuringiensis subsp.
sicon





kurstaki.
esculentum






(tomato)


A-93
8338
Monsanto
Introduction of a gene sequence encoding the enzyme 1-
Lycoper-




Company
aminocyclopropane-1-carboxylic acid deaminase
sicon





(ACCd) that metabolizes the precursor of the fruit
esculentum





ripening hormone ethylene.
(tomato)


A-94
1345-4
DNA Plant
Delayed ripening tomatoes produced by inserting an
Lycoper-




Technology
additional copy of a truncated gene encoding 1-
sicon




Corporation
aminocyclopropane-1-carboxylic acid (ACC) synthase,
esculentum





which resulted in downregulation of the endogenous
(tomato)





ACC synthase and reduced ethylene accumulation.



A-95
35 1 N
Agritope Inc.
Introduction of a gene sequence encoding the enzyme S-
Lycoper-





adenosylmethionine hydrolase that metabolizes the
sicon





precursor of the fruit ripening hormone ethylene.
esculentum






(tomato)


A-96
B, Da, F
Zeneca Seeds
Delayed softening tomatoes produced by inserting a
Lycoper-





truncated version of the polygalacturonase
sicon





(PG)-encoding gene in the sense or anti-sense
esculentum





orientation in order to reduce expression of the
(tomato)





endogenous PG gene, and thus reduce pectin






degradation.



A-97
FLAVR SAVR
Calgene Inc.
Delayed softening tomatoes produced by inserting an
Lycoper-





additional copy of the polygalacturonase (PG)-encoding
sicon





gene in the anti-sense orientation in order to reduce
esculentum





expression of the endogenous PG gene and thus reduce
(tomato)





pectin degradation.



A-98
J101, J163
Monsanto
Glyphosate herbicide-tolerant alfalfa (Lucerne) produced
Medicago




Company und
by inserting a gene encoding the enzyme 5-
sativa




Forage Genetics
enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(alfalfa)




International
from the CP4 strain of Agrobacterium tumefaciens.



A-99
C/F/93/08-02
Societe National
Tolerance to the herbicides bromoxynil and ioxynil by
Nicotiana




d'Exploitation
incorporation of the nitrilase gene from Klebsiella
tabacum L.




des Tabacs et
pneumoniae.
(tobacco)




Allumettes




A-
Vector 21-41
Vector Tobacco
Reduced nicotine content through introduction of a
Nicotiana


100

Inc.
second copy of the tobacco quinolinic acid
tabacum L.





phosphoribosyltransferase (QTPase) in the antisense
(tobacco)





orientation. The NPTII-encoding gene from E. coli was






introduced as a selectable marker to identify






transformants.



A-
CL121,
BASF Inc.
Tolerance to the imidazolinone herbicide imazethapyr,
Oryza sativa


101
CL141, CFX51

induced by chemical mutagenesis of the acetolactate
(rice)





synthase (ALS) enzyme using ethyl methanesulfonate






(EMS).



A-
GAT-OS2

Glufosinate tolerance; WO 01/83818
Oryza sativa


102



(rice)


A-
GAT-OS3

Glufosinate tolerance; US 2008-289060
Oryza sativa


103



(rice)


A-
IMINTA-1,
BASF Inc.
Tolerance to imidazolinone herbicides induced by
Oryza sativa


104
IMINTA-4

chemical mutagenesis of the acetolactate synthase (ALS)
(rice)





enzyme using sodium azide.



A-
LLRICE06,
Aventis
Glufosinate ammonium herbicide-tolerant rice produced
Oryza sativa


105
LLRICE62
CropScience
by inserting a modified phosphinothricin
(rice)





acetyltransferase (PAT)-encoding gene from the soil






bacterium Streptomyces hygroscopicus.



A-
LLRICE601
Bayer Crop-
Glufosinate ammonium herbicide-tolerant rice produced
Oryza sativa


106

Science
by inserting a modified phosphinothricin
(rice)




(Aventis
acetyltransferase (PAT)-encoding gene from the soil





CropScience
bacterium Streptomyces hygroscopicus.





(AgrEvo))




A-
PE-7

Insect resistance (Cry1Ac); WO 2008/114282
Oryza sativa


107



(rice)


A-
PWC16
BASF Inc.
Tolerance to the imidazolinon herbicide imazethapyr,
Oryza sativa


108


induced by chemical mutagenesis of the acetolactate
(rice)





synthase (ALS) enzyme using ethyl methanesulfonate






(EMS).



A-
TT51

Insect resistance (Cry1Ab/Cry1Ac); CN1840655
Oryza sativa


109



(rice)


A-
C5
United States
Plum pox virus (PPV)-resistant plum tree produced
Prunus


110

Department of
through Agrobacterium-mediated transformation with a
domestica




Agriculture-
coat protein (CP) gene from the virus.
(plum)




Agricultural






Research






Service





EH92-527
BASF Plant
Crop composition; Amflora; Unique EU identifier: BPS-





Science
25271-9



A-
ATBT04-6,
Monsanto
Colorado potato beetle-resistant potatoes produced by
Solanum


111
ATBT04-27,
Company
inserting the cry3A gene from Bacillus thuringiensis
tuberosum



ATBT04-30,

(subsp. tenebrionis).
L.



ATBT04-31,


(potato)



ATBT04-36,






SPBT02-5,






SPBT02-7





A-
BT6, BT10,
Monsanto
Colorado potato beetle-resistant potatoes produced by
Solanum


112
BT12, BT16,
Company
inserting the cry3A gene from Bacillus thuringiensis
tuberosum L.



BT17, BT18,

(subsp. tenebrionis).
(potato)



BT23





A-
RBMT15-101,
Monsanto
Colorado potato beetle- and potato Y-virus (PVY)-
Solanum


113
SEMT15-02,
Company
resistant potatoes produced by inserting the cry3A gene
tuberosum L.



SEMT15-15

from Bacillus thuringiensis (subsp. tenebrionis) and the (potato)






coat protein-encoding gene from PVY.



A-
RBMT21-129,
Monsanto
Colorado potato beetle- and potato leaf roll virus
Solanum


114
RBMT21-350,
Company
(PLRV)-resistant potatoes produced by inserting the
tuberosum



RBMT22-082

cry3A gene from Bacillus thuringiensis (subsp.
L.





tenebrionis) and the replicase-encoding gene from
(potato)





PLRV.



A-
AP205CL
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum


115


acetohydroxy acid synthase (AHAS), also known as
aestivum





acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)





lyase.



A-
AP602CL
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum


116


acetohydroxy acid synthase (AHAS), also known as
aestivum





acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)





lyase.



A-
BW255-2,
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum


117
BW238-3

acetohydroxy acid synthase (AHAS), also known as
aestivum





acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)





lyase.



A-
BW7
BASF Inc.
Tolerance to imidazolinone herbicides induced by
Triticum


118


chemical mutagenesis of the acetohydroxy acid synthase
aestivum





(AHAS) gene using sodium azide.
(wheat)


A-
Event 1

Fusarium resistance (trichothecene 3-0-
Triticum


119


cetyltransferase); CA 2561992
aestivum






(wheat)


A-
JOPLIN1

Disease (fungal) resistance (trichothecene 3-O-
Triticum


120


acetyltransferase); US 2008064032
aestivum






(wheat)


A-
MON71800
Monsanto
Glyphosate-tolerant wheat variety produced by inserting 
Triticum


121

Company
a modified 5-enolpyruvylshikimate-3-phosphate
aestivum





synthase (EPSPS)-encoding gene from the CP4 strain of
(wheat)





the soil bacterium Agrobacterium tumefaciens.



A-
SWP965001
Cyanamid Crop
Selection for a mutagenized version of the enzyme
Triticum


122

Protection
acetohydroxy acid synthase (AHAS), also known as
aestivum





acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)





lyase.



A-
Teal 11A
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum


123


acetohydroxy acid synthase (AHAS), also known as
aestivum





acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)





lyase.



A-
176
Syngenta Seeds,
Insect-resistant maize produced by inserting the cry1Ab
Zea mays


124

Inc.
gene from Bacillus thuringiensis subsp. kurstaki. The
L. (maize)





genetic modification affords resistance to attack by the






European Corn Borer (ECB).



A-
3272

Self-processing corn (alpha-amylase); US 2006-230473
Zea mays L.


125



(maize)


A-
3751IR
Pioneer Hi-Bred
Selection of somaclonal variants by culture of embryos
Zea mays


126

International
on imidazolinone-containing media.
L. (maize)




Inc.




A-
676, 678, 680
Pioneer Hi-Bred
Male-sterile and glufosinate ammonium herbicide-
Zea mays


127

International
tolerant maize produced by inserting genes encoding
L. (maize)




Inc.
DNA adenine methylase and phosphinothricin






acetyltransferase (PAT) from Escherichia coli and






Streptomyces viridochromogenes.



A-
ACS-ZMØØ3-
Bayer Crop-
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


128
2 × MON-
Science
hybrid derived from conventional cross-breeding of the
L. (maize)



ØØ81Ø-6
(Aventis
parental lines T25 (OECD identifier: ACS-ZMØØ3-2)





CropScience
and MON810 (OECD identifier: MON-ØØ81Ø-6).





(AgrEvo))




A-
B16

Glufosinate resistance; US 2003-126634
Zea mays L.


129



(maize)


A-
B16 (DLL25)
Dekalb Genetics
Glufosinate ammonium herbicide-tolerant maize
Zea mays


130

Corporation
produced by inserting the gene encoding
L. (maize)





phosphinothricin acetyltransferase (PAT) from






Streptomyces hygroscopicus.



A-
BT11
Syngenta Seeds,
Insect-resistant and herbicide-tolerant maize produced
Zea mays


131
(X4334CBR,
Inc.
by inserting the cry1Ab gene from Bacillus thuringiensis
L. (maize)



X4734CBR)

subsp. kurstaki, and the phosphinothricin N-






acetyltransferase (PAT)-encoding gene from S.






viridochromogenes.



A-
BT11 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


132
MIR604
Inc.
produced by conventional cross-breeding of parental
L. (maize)





lines BT11 (OECD unique identifier: SYN-BTØ11-1)






and MIR604 (OECD unique identifier: SYN-IR6Ø5-5).






Resistance to the European Corn Borer and tolerance to






the herbicide glufosinate ammonium (Liberty) is derived






from BT11, which contains the cry1Ab gene from






Bacillus thuringiensis subsp. kurstaki, and the






phosphinothricin N-acetyltransferase (PAT)-encoding






gene from S. viridochromogenes. Corn rootworm-






resistance is derived from MIR604 which contains the






mcry3A-gene from Bacillus thuringiensis.



A-
BT11 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


133
MIR604 ×
Inc.
produced by conventional cross-breeding of parental
L. (maize)



GA21

lines BT11 (OECD unique identifier: SYN-BTØ11-1),






MIR604 (OECD unique identifier: SYN-IR6Ø5-5) and






GA21 (OECD unique identifier: MON- Ø Ø Ø21-9).






Resistance to the European Corn Borer and tolerance to






the herbicide glufosinate ammonium (Liberty) is derived






from BT11, which contains the cry1Ab gene from






Bacillus thuringiensis subsp. kurstaki, and the






phosphinothricin N-acetyltransferase (PAT)-encoding






gene from S. viridochromogenes. Corn rootworm-






resistance is derived from MIR604 which contains the






mcry3A gene from Bacillus thuringiensis. Tolerance to






glyphosate herbicide is derived from GA21 which






contains a modified EPSPS gene from maize.



A-
CBH-351
Aventis
Insect-resistant and glufosinate ammonium herbicide-
Zea mays


134

CropScience
tolerant maize developed by inserting the genes
L. (maize)





encoding Cry9C protein from Bacillus thuringiensis






subsp. tolworthi and phosphinothricin acetyltransferase






(PAT) from Streptomyces hygroscopicus.



A-
DAS-06275-8
DOW
Lepidopteran insect-resistant and glufosinate ammonium
Zea mays


135

AgroSciences
herbicide-tolerant maize variety produced by inserting
L. (maize)




LLC
the cry1F gene from Bacillus thuringiensis var. aizawai






and the phosphinothricin acetyltransferase (PAT) from






Streptomyces hygroscopicus.



A-
DAS-59122-7
DOW
Corn rootworm-resistant maize produced by inserting
Zea mays


136

AgroSciences
the cry34Ab1 and cry35Ab1 genes from the PS149B1
L. (maize)




LLC and
strain of Bacillus thuringiensis. The PAT-encoding gene





Pioneer Hi-Bred
from Streptomyces viridochromogenes was introduced





International
as a selectable marker; US 2006-070139





Inc.




A-
DAS-59122-7 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


137
NK603
AgroSciences
produced by conventional cross-breeding of parental
L. (maize)




LLC and
lines DAS-59122-7 (OECD unique identifier: DAS-





Pioneer Hi-Bred
59122-7) with NK603 (OECD unique identifier: MON-





International
ØØ6Ø3-6). Corn rootworm-resistance is derived from





Inc.
line DAS-59122-7 which contains the cry34Ab1 and






cry35Ab1 genes from the PS149B1 strain of Bacillus






thuringiensis. Tolerance to glyphosate herbicide is






derived from NK603.



A-
DAS-59122-7 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


138
TC1507 ×
AgroSciences
produced by conventional cross-breeding of parental
L. (maize)



NK603
LLC and
lines DAS-59122-7 (OECD unique identifier: DAS-





Pioneer Hi-Bred
59122-7) and TC1507 (OECD unique identifier DAS-





International
Ø15Ø7-1) with NK603 (OECD unique identifier: MON-





Inc.
ØØ6Ø3-6). Corn rootworm-resistance is derived from






line DAS-59122-7, which contains the cry34Ab1 and






cry35Ab1 genes from the PS149B1 strain of Bacillus






thuringiensis. Lepidopteran resistance and tolerance to






glufosinate ammonium herbicide are derived from






TC1507. Tolerance to glyphosate herbicide is derived






from NK603.



A-
DAS-Ø15Ø7-1 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


139
MON-
AgroSciences
derived from conventional cross-breeding of the parental
L. (maize)



ØØ6Ø3-6
LLC
lines 1507 (OECD identifier: DAS-Ø15Ø7-1) and






NK603 (OECD identifier: MON-ØØ6Ø3-6).



A-
DBT418
Dekalb Genetics
Insect-resistant and glufosinate ammonium herbicide-
Zea mays


140

Corporation
tolerant maize developed by inserting genes encoding
L. (maize)





Cry1AC protein from Bacillus thuringiensis subsp






kurstaki and phosphinothricin acetyltransferase (PAT)






from Streptomyces hygroscopicus.



A-
DK404SR
BASF Inc.
Somaclonal variants with a modified acetyl-CoA-
Zea mays


141


carboxylase (ACCase) were selected by culture of
L. (maize)





embryos on sethoxydim-enriched medium.



A-
DP-098140-6

Glyphosate tolerance/ALS inhibitor tolerance;
Zea mays L. 


142


WO 2008/112019
(maize)


A-
DP-Ø9814Ø-6
Pioneer Hi-Bred
Maize line 98140 was genetically engineered to express
Zea mays


143
(Event 98140)
International
the GAT4621 (glyphosate acetyltransferase) and ZM-
L. (maize)




Inc.
HRA (modified maize version of a acetolactate synthase)






proteins. The GAT4621 protein, encoded by the gat4621






gene, confers tolerance to glyphosate-containing






herbicides by acetylating glyphosate and thereby






rendering it non-phytotoxic. The ZM-HRA protein,






encoded by the zm-hra gene, confers tolerance to the






ALS-inhibiting class of herbicides.



A-
Event 3272
Syngenta Seeds,
Maize line expressing a heat-stable alpha-amylase gene
Zea mays


144

Inc.
amy797E for use in the dry-grind ethanol production
L. (maize)





process. The phosphomannose isomerase gene from E.






coli was used as a selectable marker.



A-
EXP1910IT
Syngenta Seeds,
Tolerance to the imidazolinone herbicide imazethapyr,
Zea mays


145

Inc. (formerly
induced by chemical mutagenesis of the acetolactate
L. (maize)




Zeneca Seeds)
synthase (ALS) enzyme using ethyl methanesulfonate






(EMS).



A-
FI117

Glyphosate resistance; US 6,040,497
Zea mays L.


146



(maize)


A-
GA21
Monsanto
Induction, by gene-gun bombardment, of a modified 5-
Zea mays


147

Company
enolpyruvylshikimate-3-phosphate synthase (EPSPS), an
L. (maize)





enzyme involved in the shikimate biosynthesis pathway






for the production of the aromatic amino acids.



A-
GAT-ZM1

Glufosinate tolerance; WO 01/51654
Zea mays L.


148



(maize)


A-
GG25

Glyphosate resistance; US 6,040,497
Zea mays L.


149



(maize)


A-
GJ11

Glyphosate resistance; US 6,040,497
Zea mays L.


150



(maize)


A-
IT
Pioneer Hi-Bred
Tolerance to the imidazolinone herbicide imazethapyr,
Zea mays


151

International
was obtained by in vitro selection of somaclonal
L. (maize)




Inc.
variants.



A-
LY038
Monsanto
Altered amino acid composition, specifically elevated
Zea mays


152

Company
levels of lysine, through the introduction of the cordapA
L. (maize)





gene, derived from Corynebacterium glutamicum,






encoding the enzyme dihydrodipicolinate synthase






(cDHDPS); US 7,157,281



A-
MIR162

Insect resistance; WO 2007142840
Zea mays L.


153



(maize)


A-
MIR604
Syngenta Seeds,
Corn rootworm-resistant maize was produced by
Zea mays


154

Inc.
transformation with a modified cry3A gene. The
L. (maize)





phosphomannose isomerase gene from E. coli was used






as a selectable marker; (Cry3a055); EP 1 737 290



A-
MIR604 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


155
GA21
Inc.
produced by conventional cross-breeding of parental
L. (maize)





lines MIR604 (OECD unique identifier: SYN-IR6Ø5-5)






and GA21 (OECD unique identifier: MON-ØØØ21-9).






Corn rootworm-resistance is derived from MIR604






which contains the mcry3A gene from Bacillus






thuringiensis. Tolerance to glyphosate herbicide is






derived from GA21.



A-
MON80100
Monsanto
Insect-resistant maize produced by inserting the cry1Ab
Zea mays


156

Company
gene from Bacillus thuringiensis subsp. kurstaki. The
L. (maize)





genetic modification affords resistance to attack by the






European Corn Borer.



A-
MON802
Monsanto
Insect-resistant and glyphosate herbicide-tolerant maize
Zea mays


157

Company
produced by inserting the genes encoding the Cry1Ab
L. (maize)





protein from Bacillus thuringiensis and the 5-






enolpyruvylshikimate-3-posphate synthase (EPSPS)






from the CP4 strain of A. tumefaciens.



A-
MON809
Pioneer Hi-Bred
Resistance to European Corn Borer (Ostrinia nubilalis)
Zea mays


158

International
by introduction of a synthetic cry1Ab gene. Glyphosate
L. (maize)




Inc.
resistance via introduction of the bacterial version of a






plant enzyme, 5-enolpyruvylshikimat-3-phosphate






synthase (EPSPS).



A-
MON810
Monsanto
Insect-resistant maize produced by inserting a truncated
Zea mays


159

Company
form of the cry1Ab gene from Bacillus thuringiensis
L. (maize)





subsp. kurstaki HD-1. The genetic modification affords






resistance to attack by the European Corn Borer (ECB);






US 2004-180373



A-
MON810 ×
Monsanto
Stacked insect-resistant and glyphosate-tolerant maize
Zea mays


160
MON88017
Company
derived from conventional cross-breeding of the parental
L. (maize)





lines MON810 (OECD identifier: MON-ØØ81Ø-6) and






MON88017 (OECD identifier: MON-88Ø17-3).






European Corn Borer (ECB) resistance is derived from a






truncated form of the cry1Ab gene from Bacillus






thuringiensis subsp. kurstaki HD-1, present in MON810.






Corn rootworm-resistance is derived from the cry3Bb1






gene from the EG4691 strain of Bacillus thuringiensis






subspecies kumamotoensis present in MON88017.






Glyphosate tolerance is derived from a 5-






enolpyruvylshikimate-3-phosphate synthase (EPSPS)-






encoding gene from the CP4 strain of Agrobacterium






tumefaciens present in MON88017.



A-
MON832
Monsanto
Introduction, by gene-gun bombardment, of glyphosate
Zea mays


161

Company
oxidase (GOX) and a modified 5-enolpyruvylshikimate-
L. (maize)





3-phosphate synthase (EPSPS), an enzyme involved in






the shikimate biosynthesis pathway for the production of






the aromatic amino acids.



A-
MON863
Monsanto
Corn rootworm-resistant maize produced by inserting
Zea mays


162

Company
the cry3Bb1 gene from Bacillus thuringiensis subsp.
L. (maize)





kumamotoensis.



A-
MON87460

Drought tolerance; water deficit tolerance; WO
Zea mays L.


163


2009/111263
(maize)


A-
MON88017
Monsanto
Corn rootworm-resistant maize produced by inserting
Zea mays


164

Company
the cry3Bb1 gene from the EG4691 strain of Bacillus
L. (maize)





thuringiensis subsp. kumamotoensis. Glyphosate






tolerance was derived by inserting a 5-






enolpyruvylshikimate-3-phosphate synthase (EPSPS)-






encoding gene from the CP4 strain of Agrobacterium






tumefaciens; WO 2005059103



A-
MON89034
Monsanto
Maize event expressing two different insecticidal
Zea mays


165

Company
proteins from Bacillus thuringiensis providing resistance
L. (maize)





to a number of lepidopteran pests; insect resistance






(Lipidoptera-Cry1A.105-Cry2Ab); WO 2007140256



A-
MON89034 ×
Monsanto
Stacked insect-resistant and glyphosate-tolerant maize
Zea mays


166
MON88017
Company
derived from conventional cross-breeding of the parental
L. (maize)





lines MON89034 (OECD identifier: MON-89 Ø34-3)






and MON88017 (OECD identifier: MON-88Ø17-3).






Resistance to lepidopteran insects is derived from two






cry genes present in MON89043. Corn rootworm-






resistance is derived from a single cry gene and






glyphosate tolerance is derived from a 5-






enolpyruvylshikimate-3-phosphate synthase (EPSPS)-






encoding gene from Agrobacterium tumefaciens present






in MON88017.



A-
MON-ØØ6Ø3-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


167
6 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)



ØØ81Ø-6

parental lines NK603 (OECD identifier: MON-ØØ6Ø3-






6) and MON810 (OECD identifier: MON-ØØ81Ø-6).



A-
MON-ØØ81Ø-
Monsanto
Stacked insect-resistant and increased lysine-content
Zea mays


168
6 × LY038
Company
maize hybrid derived from conventional cross-breeding
L. (maize)





of the parental lines MON810 (OECD identifier: MON-






ØØ81Ø-6) and LY038 (OEC identifier: REN-ØØØ38-






3).



A-
MON-ØØ863-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


169
5 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)



ØØ6Ø3-6

parental lines MON863 (OECD identifier: MON-






ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-






6).



A-
MON-00863-
Monsanto
Stacked insect-resistant maize hybrid derived from
Zea mays


170
5 × MON-
Company
conventional cross-breeding of the parental lines
L. (maize)



00810-6

MON863 (OECD identifier: MON-ØØ863-5) and






MON810 (OECD identifier: MON-ØØ81Ø-6)



A-
MON-ØØ863-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


171
5 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)



ØØ81Ø-6 × 

stacked hybrids MON-ØØ863-5 × MON-ØØ81Ø-6 and




MON-ØØ6Ø3-

NK603 (OECD identifier: MON-ØØ6Ø3-6).




6





A-
MON-ØØØ21-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


172
9 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)



ØØ81Ø-6

parental lines GA21 (OECD identifier: MON-ØØØ21-9)






and MON810 (OECD identifier: MON-ØØ81Ø-6).



A-
MS3
Bayer Crop-
Male sterility caused by expression of the barnase
Zea mays


173

Science
ribonuclease gene from Bacillus amyloliquefaciens; PPT
L. (maize)




(Aventis
resistance was obtained via PPT acetyltransferase (PAT).





CropScience






(AgrEvo))




A-
MS6
Bayer Crop-
Male sterility caused by expression of the barnase
Zea mays


174

Science
ribonuclease gene from Bacillus amyloliquefaciens; PPT
L. (maize)




(Aventis
resistance was attained via PPT acetyltransferase (PAT).





CropScience






(AgrEvo))




A-
NK603
Monsanto
Introduction by gene-gun bombardment of a modified 5-
Zea mays


175

Company
enolpyruvylshikimate-3-phosphate synthase (EPSPS), an
L. (maize)





enzyme involved in the shikimate biosynthesis pathway






for the production of the aromatic amino acids.



A-
PV-ZMGT32

Glyphosate tolerance; US 2007-056056
Zea mays L.


176
(NK603)


(maize)


A-
PV-

Glyphosate tolerance; US 2007292854
Zea mays L.


177
ZMGT32(nk60


(maize)



3)





A-
PV-ZMIR13

Insect resistance (Cry3Bb); US 2006-095986
Zea mays L.


178
(MON863)


(maize)


A-
SYN-BTØ11-1 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


179
MON-
Inc.
produced by conventional cross-breeding of parental
L. (maize)



ØØØ21-9

lines BT11 (OECD unique identifier: SYN-BTØ11-1)






and GA21 (OECD unique identifier: MON-ØØØ21-9).



A-
T14, T25
Bayer
Glufosinate herbicide-tolerant maize produced by
Zea mays


180

CropScience
inserting the phosphinothricin N-acetyltranferase (PAT)-
L. (maize)




(Aventis
encoding gene from the aerobic actinomycete





CropScience
Streptomyces viridochromogenes.





(AgrEvo))




A-
TC1507
Mycogen (c/o
Insect-resistant and glufosinate ammonium
Zea mays


181

Dow
herbicide-tolerant maize produced by inserting the cry1F
L. (maize)




AgroSciences);
gene from Bacillus thuringiensis var. aizawai and the





Pioneer (c/o 
phosphinothricin N-acetyltransferase-encoding gene





Dupont)
from Streptomyces viridochromogenes.



A-
TC1507 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize
Zea mays


182
DAS-59122-7
AgroSciences
produced by conventional cross-breeding of parental
L. (maize)




LLC and
lines TC1507 (OECD unique identifier: DAS-Ø15Ø7-1)





Pioneer Hi-Bred
with DAS-59122-7 (OECD unique identifier: DAS-





International
59122-7). Resistance to lepidopteran insects is derived





Inc.
from TC1507 due to the presence of the cry1F gene from






Bacillus thuringiensis var. aizawai. Corn rootworm-






resistance is derived from line DAS-59122-7 which






contains the cry34Abl and cry35Ab1 genes from






Bacillus.






Thuringiensis strain PS149B1. Tolerance to glufosinate






ammonium herbicide is derived from TC1507 from the






phosphinothricin N-acetyltransferase-encoding gene






from Streptomyces viridochromogenes.



A-
VIP1034

Insect resistance; WO 03/052073
Zea mays L.


183



(maize)









In one embodiment of the invention the plants B-1 to B-129 of table B, in total or in part, or propagation material of said plants, is treated or contacted with the active ingredient combinations of the invention, alone or in the form of compositions comprising an active ingredient combination.







TABLE B







Non-exhaustive list of transgenic plants to carry out the invention from the APHIS database of the


United States Department of Agriculture (USDA). The database can be found on:


http://www.aphis.usda.gov/animal_welfare/efoia/index.shtml.



















EA final




Extension of


Transformation
conclusion &


No.
Petition
Petition***
Institution
Plant
Event or Line
determination





B-1
10-070-01p

Virginia Tech
Peanut
Sclerotinia
N70, P39 and







blight-resistant
W171


B-2
09-349-01p

Dow
Soya bean
2,4-D- and
DAS-68416-4





AgroSciences

glufosinate







tolerance


B-3
09-328-01p

Bayer Crop
Soya bean
glyphosate and
FG72





Science

isoxaflutole







tolerance


B-4
09-233-01p

Dow
Maize
2,4-D and ACCase-
DAS-40278-9







inhibitor tolerance


B-5
09-201-01p

Monsanto
Soya bean
improved fatty acid
MON-877Ø5-6







profile


B-6
09-183-01p

Monsanto
Soya bean
stearidonic acid
MON-87769







production


B-7
09-082-01p

Monsanto
Soya bean
Lepidopteran
MON 87701







resistance


B-8
09-063-01p

Stine Seed
Maize
Glyphosate
HCEM485







tolerance


B-9
09-055-01p

Monsanto
Maize
Drought tolerance
MON 87460


B-10
09-015-01p

BASF Plant
Soya bean
Imidazolinon
BPS-CV127-9





Science, LLC

tolerance
Soya bean


B-11
08-366-01p

ArborGen
Eucalyptus
Freeze tolerance,
ARB-FTE1-08







fertility altered


B-12
08-340-01p

Bayer
Cotton
Glufosinate
T304-40XGHB119







tolerance, insect







resistance


B-13
08-338-01p

Pioneer
Maize
Male sterility,
DP-32138-1







fertility restored,







visual marker


B-14
08-315-01p

Florigene
Rose
Altered flower
IFD-524Ø1-4 and







color
IFD-529Ø1-9


B-15
07-108-01p

Syngenta
Cotton
Lepidopteran
COT67B







resistance


B-16
06-354-01p

Pioneer
Soya bean
High oleic acid
DP-3Ø5423-1


B-17




content


B-18
05-280-01p

Syngenta
Maize
Thermostable
3272


B-19




alpha-amylase


B-20
04-110-01p

Monsanto &
Alfalfa
Glyphosate
J101, J163


B-21


Forage Genetics

tolerance


B-22


B-23


B-24
03-104-01p

Monsanto &
Creeping
Glyphosate
ASR368


B-25


Scotts
bentgrass
tolerance


B-26


B-27


B-28


B-29


B-30
07-253-01p

Syngenta
Maize
Lepidopteran
MIR-162 Maize


B-31




resistance


B-32
07-152-01p

Pioneer
Maize
Glyphosate &
DP-098140-6


B-33




imidazolinone







tolerance


B-34
04-337-01p

University of
Papaya
Papaya ringspot
X17-2


B-35


Florida

virus-resistant


B-36
06-332-01p

Bayer
Cotton
Glyphosate
GHB614


B-37


Crop Science

tolerance


B-38
06-298-01p

Monsanto
Maize
European Corn
MON 89034


B-39




Borer resistance


B-40
06-271-01p

Pioneer
Soya bean
Glyphosate &
356043


B-41




acetolactate
(DP-356Ø43-5)







synthase tolerance


B-42
06-234-01p
98-329-01p
Bayer
Rice
Phosphinothricin
LLRICE601


B-43


Crop Science

tolerance


B-44
06-178-01p

Monsanto
Soya bean
Glyphosate
MON 89788


B-45




tolerance


B-46
04-362-01p

Syngenta
Maize
Corn
MIR604


B-47




rootworm-protected


B-48


B-49
04-264-01p

ARS
Plum
Plum Pox
C5


B-50




virus-resistant


B-51
04-229-01p

Monsanto
Maize
High lysine content
LY038


B-52


B-53
04-125-01p

Monsanto
Maize
Corn rootworm-
88017


B-54




resistance


B-55
04-086-01p

Monsanto
Cotton
Glyphosate
MON 88913


B-56




tolerance


B-57


B-58
03-353-01p

Dow
Maize
Corn rootworm-
59122


B-59




resistance


B-60
03-323-01p

Monsanto
Sugar beet
Glyphosate
H7-1


B-61




tolerance


B-62
03-181-01p
00-136-01p
Dow
Maize
Lepidopteran
TC-6275


B-63




resistance &







phosphinothricin







tolerance


B-64
03-155-01p

Syngenta
Cotton
Lepidopteran
COT 102


B-65




resistance


B-66
03-036-01p

Mycogen/Dow
Cotton
Lepidopteran
281-24-236


B-67




resistance


B-68
03-036-02p

Mycogen/Dow
Cotton
Lepidopteran
3006-210-23


B-69




resistance


B-70
02-042-01p

Aventis
Cotton
Phosphinothricin
LLCotton25







tolerance


B-71
01-324-01p
98-216-01p
Monsanto
Oilseed
Glyphosate
RT200






rape
tolerance


B-72
01-206-01p
98-278-01p
Aventis
Oilseed
Phosphinothricin-
MS1 & RF1/RF2






rape
tolerance &







pollination control


B-73
01-206-02p
97-205-01p
Aventis
Oilseed
phosphinothricin
Topas 19/2






rape
tolerance


B-74
01-137-01p

Monsanto
Maize
Corn rootworm-
MON 863







resistance


B-75
01-121-01p

Vector
Tobacco
Reduced nicotine
Vector 21-41







content


B-76
00-342-01p

Monsanto
Cotton
Lepidopteran
Cotton Event







resistance
15985


B-77
00-136-01p

Mycogen c/o
Maize
Lepidopteran
Line 1507





Dow & Pioneer

resistance &







phosphinothricin







tolerance


B-78
00-011-01p
97-099-01p
Monsanto
Maize
Glyphosate
NK603







tolerance


B-79
99-173-01p
97-204-01p
Monsanto
Potato
PLRV & CPB
RBMT22-82







resistance


B-80
98-349-01p
95-228-01p
AgrEvo
Maize
Phosphinothricin
MS6







tolerance and male







sterility


B-81
98-335-01p

U. of
Flax
Tolerant to soil
CDC Triffid





Saskatchewan

residues of







sulfonylurea







herbicide


B-82
98-329-01p

AgrEvo
Rice
Phosphinothricin
LLRICE06,







tolerance
LLRICE62


B-83
98-278-01p

AgrEvo
Oilseed
Phosphinothricin
MS8 & RF3






rape
tolerance &







pollination control


B-84
98-238-01p

AgrEvo
Soya bean
phosphinothricin
GU262







tolerance


B-85
98-216-01p

Monsanto
Oilseed
Glyphosate
RT73






rape
tolerance


B-86
98-173-01p

Novartis Seeds
Beet
Glyphosate
GTSB77





& Monsanto

tolerance


B-87
98-014-01p
96-068-01p
AgrEvo
Soya bean
Phosphinothricin
A5547-127







tolerance


B-88
97-342-01p

Pioneer
Maize
Male sterility &
676, 678, 680







phosphinothricin







tolerance


B-89
97-339-01p

Monsanto
Potato
CPB & PVY
RBMT15-101,







resistance
SEMT15-02,








SEMT15-15


B-90
97-336-01p

AgrEvo
Beet
phosphinothricin
T-120-7







tolerance


B-91
97-287-01p

Monsanto
Tomato
Lepidopteran
5345







resistance


B-92
97-265-01p

AgrEvo
Maize
Phosphinothricin
CBH-351







tolerance &







Lepidopteran







resistance


B-93
97-205-01p

AgrEvo
Oilseed
Phosphinothricin
T45






rape
tolerance


B-94
97-204-01p

Monsanto
Potato
CPB & PLRV
RBMT21-129 &







resistance
RBMT21-350


B-95
97-148-01p

Bejo
Cichorium
Male sterility
RM3-3, RM3-4,






intybus

RM3-6


B-96
97-099-01p

Monsanto
Maize
Glyphosate
GA21







tolerance


B-97
97-013-01p

Calgene
Cotton
Bromoxynil
Events 31807 &







tolerance &
31808







Lepidopteran







resistance


B-98
97-008-01p

Du Pont
Soya bean
Oil profile altered
G94-1, G94-19, G-








168


B-99
96-317-01p

Monsanto
Maize
Glyphosate
MON802







tolerance & ECB







resistance


B-100
96-291-01p

DeKalb
Maize
European Corn
DBT418







Borer resistance


B-101
96-248-01p
92-196-01p
Calgene
Tomato
Fruit ripening
1 additional







altered
FLAVRSAVR line


B-102
96-068-01p

AgrEvo
Soya bean
Phosphinothricin
W62, W98,







tolerance
A2704-12, A2704-








21, A5547-35


B-103
96-051-01p

Cornell U
Papaya
PRSV resistance
55-1, 63-1


B-104
96-017-01p
95-093-01p
Monsanto
Maize
European Corn
MON809 &







Borer resistance
MON810


B-105
95-352-01p

Asgrow
Summer
CMV, ZYMV,
CZW-3






squash
WMV2 resistance


B-106
95-338-01p

Monsanto
Potato
CPB resistance
SBT02-5 & -7,








ATBT04-6 &-27, -








30, -31, -36


B-107
95-324-01p

Agritope
Tomato
Fruit ripening
35 1 N







altered


B-108
95-256-01p

Du Pont
Cotton
Sulfonylurea
19-51a







resistance


B-109
95-228-01p

Plant Genetic
Maize
Male sterile
MS3





Systems


B-110
95-195-01p

Northrup King
Maize
European Corn
Bt11







Borer resistance


B-111
95-179-01p
92-196-01p
Calgene
Tomato
Fruit ripening
2 additional







altered
FLAVRSAVR-








lines


B-112
95-145-01p

DeKalb
Maize
Phosphinothricin
B16







tolerance


B-113
95-093-01p

Monsanto
Maize
Lepidopteran
MON 80100







resistance


B-114
95-053-01p

Monsanto
Tomato
Fruit ripening
8338







altered


B-115
95-045-01p

Monsanto
Cotton
Glyphosate
1445, 1698







tolerance


B-116
95-030-01p
92-196-01p
Calgene
Tomato
Fruit ripening
20 additional







altered
FLAVRSAVR








lines


B-117
94-357-01p

AgrEvo
Maize
Phosphinothricin
T14, T25







tolerance


B-118
94-319-01p

Ciba Seeds
Maize
Lepidopteran
Event 176







resistance


B-119
94-308-01p

Monsanto
Cotton
Lepidopteran
531, 757, 1076







resistance


B-120
94-290-01p

Zeneca &
Tomato
Fruit
B, Da, F





Petoseed

polygalacturonase







level decreased


B-121
94-257-01p

Monsanto
Potato
Coleopteran
BT6, BT10, BT12,







resistance
BT16, BT17,








BT18, BT23


B-122
94-230-01p
92-196-01p
Calgene
Tomato
Fruit ripening
9 additional







altered
FLAVRSAVR








lines


B-123
94-228-01p

DNA Plant Tech
Tomato
Fruit ripening
1345-4







altered


B-124
94-227-01p
92-196-01p
Calgene
Tomato
Fruit ripening
Line N73 1436-







altered
111


B-125
94-090-01p

Calgene
Oilseed
Oil profile altered
pCGN3828-






rape

212/86-18 & 23


B-126
93-258-01p

Monsanto
Soya bean
Glyphosate
40-3-2







tolerance


B-127
93-196-01p

Calgene
Cotton
Bromoxynil
BXN







tolerance


B-128
92-204-01p

Upjohn
Summer
WMV2 & ZYMV
ZW-20






squash
resistance


B-129
92-196-01p

Calgene
Tomato
Fruit ripening
FLAVR SAVR







altered





Abbreviations used in this table:


CMV—cucumber mosaic virus,


CPB—Colorado potato beetle,


PLRV—potato leafroll virus,


PRSV—papaya ringspot virus,


PVY—potato virus Y,


WMV2—watermelon mosaic virus 2


ZYMV—zucchini yellow mosaic virus






In one embodiment the plants which comprise a transgenic event as per D-1 to D-48 of table D or express such a trait, in whole or in part, or propagation material of these plants, are or is contacted or treated with the active ingredient combinations of the invention, alone or in the form of compositions which comprise an active ingredient combination.







TABLE D







Non-exhaustive list of transgenic events and traits the invention can be worked on, 


with reference to patent applications.











No.
Plant species 
Transgenic event
Trait
Patent reference





D-1
Maize
PV-ZMGT32 (NK603)
Glyphosate tolerance
US 2007-056056


D-2
Maize
MIR604
Insect resistance (Cry3a055)
EP-A 1 737 290


D-3
Maize
LY038
High lysine content
U.S. Pat. No. 7,157,281


D-4
Maize
3272
Self-processing maize
US 2006-230473





(alpha-amylase)



D-5
Maize
PV-ZMIR13 (MON863)
Insect resistance (Cry3Bb)
US 2006-095986


D-6
Maize
DAS-59122-7
Insect resistance
US 2006-070139





(Cry34Ab1/Cry35Ab1)



D-7
Maize
TC1507
Insect resistance (Cry1F)
U.S. Pat. No. 7,435,807


D-8
Maize
MON810
Insect resistance (Cry1Ab)
US 2004-180373


D-9
Maize
VIP1034
Insect resistance
WO 03/052073


D-10
Maize
B16
Glufosinate resistance
US 2003-126634


D-11
Maize
GA21
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-12
Maize
GG25
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-13
Maize
GJ11
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-14
Maize
FI117
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-15
Maize
GAT-ZM1
Glufosinate tolerance
WO 01/51654


D-16
Maize
DP-098140-6
Glyphosate tolerance/ALS-
WO 2008/112019





inhibitor tolerance



D-17
Wheat
Event 1
Fusarium resistance
CA 2561992





(trichothecene 3-O-






acetyltransferase)



D-18
Sugar beet
T227-1
Glyphosate tolerance
US 2004-117870


D-19
Sugar beet
H7-1
Glyphosate tolerance
WO 2004-074492


D-20
Soya bean
MON89788
Glyphosate tolerance
US 2006-282915


D-21
Soya bean
A2704-12
Glufosinate tolerance
WO 2006/108674


D-22
Soya bean
A5547-35
Glufosinate tolerance
WO 2006/108675


D-23
Soya bean
DP-305423-1
High oleic acid/ALS-
WO 2008/054747





inhibitor tolerance



D-24
Rice
GAT-OS2
Glufosinate tolerance
WO 01/83818


D-25
Rice
GAT-OS3
Glufosinate tolerance
US 2008-289060


D-26
Rice
PE-7
Insect resistance (Cry1Ac)
WO 2008/114282


D-27
Oilseed rape
MS-B2
Male sterility
WO 01/31042


D-28
Oilseed rape
MS-BN1/RF-BN1
Male sterility/restoration
WO 01/41558


D-29
Oilseed rape
RT73
Glyphosate resistance
WO 02/36831


D-30
Cotton
CE43-67B
Insect resistance (Cry1Ab)
WO 2006/128573


D-31
Cotton
CE46-02A
Insect resistance (Cry1Ab)
WO 2006/128572


D-32
Cotton
CE44-69D
Insect resistance (Cry1Ab)
WO 2006/128571


D-33
Cotton
1143-14A
Insect resistance (Cry1Ab)
WO 2006/128569


D-34
Cotton
1143-51B
Insect resistance (Cry1Ab)
WO 2006/128570


D-35
Cotton
T342-142
Insect resistance (Cry1Ab)
WO 2006/128568


D-36
Cotton
event3006-210-23
Insect resistance (Cry1Ac)
WO 2005/103266


D-37
Cotton
PV-GHGT07 (1445)
Glyphosate tolerance
US 2004-148666


D-38
Cotton
MON88913
Glyphosate tolerance
WO 2004/072235


D-39
Cotton
EE-GH3
Glyphosate tolerance
WO 2007/017186


D-40
Cotton
T304-40
Insect resistance (Cry1Ab)
WO2008/122406


D-41
Cotton
Cot202
Insect resistance (VIP3)
US 2007-067868


D-42
Cotton
LLcotton25
Glufosinate resistance
WO 2007/017186


D-43
Cotton
EE-GH5
Insect resistance (Cry1Ab)
WO 2008/122406


D-44
Cotton
event 281-24-236
Insect resistance (Cry1F)
WO 2005/103266


D-45
Cotton
Cot102
Insect resistance (Vip3A)
US 2006-130175


D-46
Cotton
MON 15985
Insect resistance
US 2004-250317





(Cry1A/Cry2Ab)



D-47
Bentgrass
Asr-368
Glyphosate tolerance
US 2006-162007


D-48
Aubergine
EE-1
Insect resistance (Cry1Ac)
WO 2007/091277









In one embodiment the plants which comprise a transgenic event as per E-1 to E-50 of table E or express such a trait, in whole or in part, or propagation material of these plants, are or is contacted or treated with the active ingredient combinations of the invention, alone or in the form of compositions which comprise an active ingredient combination.







TABLE E







Non-exhaustive list oftransgenic events and traits and their trade names.












No.
Trade name
Plant
Company
Genetically modified properties
Additional information





E-1
Roundup
Beta vulgaris
Monsanto
Glyphosate tolerance




Ready ®
(sugar beet)
Company




E-2
InVigor ®
Brassica napus
Bayer
Canola rape was genetically modified with the following





(Argentine
CropScience
result:





canola rape)

Ø expression of a gene which confers tolerance to the







herbicide glyfosinate ammonium;







Ø introduction of a novel hybrid breeding system for







canola rape which is based on genetically modified male-







sterility (MS) and fertility-restorer (RF) lines;







Ø expression of a gene for resistance to antibiotics.



E-3
Liberty Link ®
Brassica napus
BayerCrop-
Phosphinotricin tolerance





(Argentine
Science






canola rape)





E-4
Roundup
Brassica
Monsanto
Glyphosate tolerance




Ready ®
napus (canola
Company






rape)





E-5
Clearfield ®
(Canola rape)
BASF
Non-GMO, imazamox tolerance






Corporation




E-6
Optimum TM
Glycine max
Pioneer Hi-
Glyphosate and ALS herbicide tolerance




GAT TM
L. (soya bean)
Bred







International,







Inc




E-7
Roundup
Glycine max
Monsanto
Glyphosate tolerance




Ready ®
L. (soya bean)
Company




E-8
Roundup
Glycine max
Monsanto
Glyphosate tolerance




RReady2Yiel TM
L. (soya bean)
Company




E-9
STS ®
Glycine max
DuPont
Sulfonylurea tolerance





L. (soya bean)





E-10
YIELD
Glycine max
Monsanto





GARD ®
L. (soya bean)
Company




E-11
AFD ®
Gossypium
Bayer
The lines include, for example, AFD5062LL, AFD5064F,





hirsutum
CropScience
AFD 5065B2F; AFD seed is available in a wide range of





L. (cotton)

varieties with integrated technology such as, for example,







the Bollgard ®, Bollgard II, Roundup Ready, Roundup







Ready Flex and LibertyLink ®technologies



E-12
Bollgard II ®
Gossypium
Monsanto
MON 15985 event: Cry2(A)b1; Cry1A(c)





hirsutum
Company






L. (cotton)





E-13
Bollgard ®
Gossypium
Monsanto
Cry1Ac





hirsutum
Company






L. (cotton)





E-14
FiberMax ®
Gossypium
Bayer






hirsutum
CropScience






L. (cotton)





E-15
Liberty Link ® 
Gossypium
Bayer
Phosphinotricin tolerance





hirsutum
CropScience






L. (cotton)





E-16
Nucotn 33B
Gossypium
Delta Pine and
Bt toxin in the lines from Delta Pine: Cry1Ac





hirsutum
Land






L. (cotton)





E-17
Nucotn 35B
Gossypium
Delta Pine and
Bt toxin in the lines from Delta Pine: Cry1Ac





hirsutum
Land






L. (cotton)





E-18
Nucotn ®
Gossypium
Delta Pine and
Bt toxin in the lines from Delta Pine





hirsutum
Land






L. (cotton)





E-19
PhytoGen TM
Gossypium
PhytoGen Seed
Comprises varieties which contain, for example,





hirsutum
Company,
Roundup Ready flex, Widestrike





L. (cotton)
Dow







AgroSciences







LLC




E-20
Roundup
Gossypium
Monsanto
Glyphosate tolerance




Ready Flex ®
hirsutum
Company






L. (cotton)





E-21
Roundup
Gossypium
Monsanto
Glyphosate tolerance




Ready ®
hirsutum
Company






L. (cotton)





E-22
Widestrike TM
Gossypium
Dow
Cry1F and Cry1Ac
Monsanto/Dow




hirsutum
AgroSciences






L. (cotton)
LLC




E-23
YIELD
Gossypium
Monsanto

http://www.garstseed.com/



GARD ®
hirsutum
Company

GarstClient/Technology/




L. (cotton)


agrisure.aspx


E-24
Roundup
Medicago
Monsanto
Glyphosate tolerance




Ready ®
sativa (alfalfa)
Company




E-25
Clearfield ®
Oryza sativa
BASF
Non-GMO, imazamox tolerance





(rice)
Corporation




E-26
NewLeaf ®
Solanum
Monsanto
Resistance to infection by potato leafroll virus (PLRV)





tuberosum
Company
and feeding damage by the Colorado beetle Leptinotarsa





L. (potato)

decemlineata



E-27
NewLeaf ®
Solanum
Monsanto
Resistance to infection by potato leafroll virus (PLRV)
http://www.dowagro.com/




plus tuberosum
Company
and feeding damage by the Colorado beetle Leptinotarsa
phytogen/index.htm




L. (potato)

decemlineata



E-28
Protecta ®
Solanum







tuberosum







L. (potato)





E-29
Clearfield ®
Sunflower
BASF
Non-GMO, imazamox tolerance






Corporation




E-30
Roundup
Triticum
Monsanto
Glyphosate tolerance, NK603




Ready ®
aestivum
Company






(wheat)





E -31 
Clearfield ®
Wheat
BASF
Non-GMO, imazamox tolerance






Corporation




E-32
Agrisure ®
Zea mays
Syngenta
These include Agrisure CB/LL (BT 11 event plus




(Family)
L. (maize)
Seeds, Inc.
phosphinotricin tolerance as the result of GA21 event);







Agrisure CB/LL/RW (Bt 11 event, modified synthetic







Cry3A gene, phosphinotricin tolerance as the result of







GA21 event); Agrisure GT (glyphosate tolerance);







Agrisure GT/CB/LL(glyphosate tolerance and







phosphinotricin tolerance as the result of GA21 event, Bt







11 event); Agrisure 3000GT (CB/LL/RW/GT: glyphosate







and phosphinotricin tolerance as the result of GA21







event; Bt 11 event, modified synthetic Cry3A gene);







Agrisure GT/RW (glyphosate tolerance, modified







synthetic Cry3A gene); Agrisure RW (modified synthetic







Cry3A gene); future traits



E-33
BiteGard ®
Zea mays
Novartis Seeds
cry1A(b) gene





L. (maize)





E-34
Bt-Xtra ®
Zea mays
DEKALB
cry1Ac gene





L. (maize)
Genetics







Corporation




E-35
Clearfield ®
Zea mays
BASF
Non-GMO, imazamox tolerance





L. (maize)
Corporation




E-36
Herculex ®
Zea mays
Dow





(Familie)
L. (maize)
Agro Sciences







LLC




E-37
IMI ®
Zea mays
DuPont
Imidazolinone tolerance





L. (maize)





E-38
KnockOut ®
Zea mays
Syngenta
SYN-EV176-9: cry1A(b) gene





L. (maize)
Seeds, Inc.




E-39
Mavera ®
Zea mays
Renessen LLC
High lysine
http://www.dowagro.com/




L. (maize)


widestrike/


E-40
NatureGard ®
Zea mays
Mycogen
cry1A(b) gene





L. (maize)





E-41
Roundup
Zea mays
Monsanto
Glyphosate tolerance
http://www.starlinkcom.com/



Ready ®
L. (maize)
Company

starlinkcorn.htm


E-42
Roundup
Zea mays
Monsanto
Glyphosate tolerance




Ready ® 2
L. (maize)
Company




E-43
SmartStax
Zea mays
Monsanto
Combination of eight genes





L. (maize)
Company




E-44
StarLink ®
Zea mays
Aventis
Cry9c gene





L. (maize)
CropScience ->







Bayer







CropScience




E-45
STS ®
Zea mays
DuPont
Sulfonylurea tolerance





L. (maize)





E-46
YIELD
Zea mays
Monsanto
Mon810, Cry1Ab1; resistance to the European Corn
http://www.dowagro.com/



GARD ®
L. (maize)
Company
Borer
herculex/about/herculexfamily/


E-47
YieldGard ®
Zea mays
Monsanto
Mon810 × Mon863, dual resistance to European Corn




Plus
L. (maize)
Company
Borer and corn rootworm



E-48
YieldGard ®
Zea mays
Monsanto
Mon863, Cry3Bb1, resistance to corn rootworm




Rootworm
L. (maize)
Company




E-49
YieldGard ®
Zea mays
Monsanto
Stacked traits




VT
L. (Maize)
Company




E-50
YieldMaker TM
Zea mays
DEKALB
Contains Roundup Ready 2 technology, YieldGard VT,





L. (Maize)
Genetics
YieldGard Corn Borer, YieldGard Rootworm and






Corporation
YieldGard Plus









Transgenic crop plants that can be treated in accordance with the invention are preferably plants which comprise transformation events (transformation-integration events) or a combination of transformation events (transformation-integration events) and which, for example, are listed in the databases for various national or regional registration authorities, including event 1143-14A (cotton, insect control, not filed, described in WO2006/128569); event 1143-51B (cotton, insect control, not filed, described in WO2006/128570); event 1445 (cotton, herbicide tolerance, not filed, described in US2002120964 or WO2002/034946); event 17053 (rice, herbicide tolerance, filed as PTA-9843, described in WO2010/117737); event 17314 (rice, herbicide tolerance, filed as PTA-9844, described in WO2010/117735); event 281-24-236 (cotton, insect control—herbicide tolerance, filed as PTA-6233, described in WO2005/103266 or US2005216969); event 3006-210-23 (cotton, insect control—herbicide tolerance, filed as PTA-6233, described in US2007143876 or WO2005/103266); event 3272 (maize, quality trait, filed as PTA-9972, described in WO2006098952 or US2006230473); event 40416 (maize, insect control—herbicide tolerance, filed as ATCC PTA-11508, described in WO2011/075593); event 43A47 (maize, insect control—herbicide tolerance, filed as ATCC PTA-11509, described in WO2011/075595); event 5307 (maize, insect control, filed as ATCC PTA-9561, described in WO2010/077816); event ASR-368 [bent grass, herbicide tolerance, filed as ATCC PTA-4816, described in US2006162007 or WO2004053062]; event B16 (maize, herbicide tolerance, not filed, described in US2003126634); event BPS-CV127-9 (soya bean, herbicide tolerance, filed as NCIMB No. 41603, described in WO2010/080829); event CE43-67B (cotton, insect control, filed as DSM ACC2724, described in US2009217423 or WO2006/128573); event CE44-69D (cotton, insect control, not filed, described in US20100024077); event CE44-69D (cotton, insect control, not filed, described in WO2006/128571); event CE46-02A (cotton, insect control, not filed, described in WO2006/128572); event COT102 (cotton, insect control, not filed, described in US2006130175 or WO2004039986); event COT202 (cotton, insect control, not filed, described in US2007067868 or WO2005054479); event COT203 (cotton, insect control, not filed, described in WO2005/054480); event DAS40278 (maize, herbicide tolerance, filed as ATCC PTA-10244, described in WO2011/022469); event DAS-59122-7 (maize, insect control—herbicide tolerance, filed as ATCC PTA 11384, described in US2006070139); event DAS-59132 (maize, insect control—herbicide tolerance, not filed, described in WO2009/100188); event DAS68416 (soya bean, herbicide tolerance, filed as ATCC PTA-10442, described in WO2011/066384 or WO2011/066360); event DP-098140-6 (maize, herbicide tolerance, filed as ATCC PTA-8296, described in US2009137395 or WO2008/112019); event DP-305423-1 (soya bean, quality trait, not filed, described in US2008312082 or WO2008/054747); event DP-32138-1 (maize, hybrid system, filed as ATCC PTA-9158, described in US20090210970 or WO2009/103049); event DP-356043-5 (soya bean, herbicide tolerance, filed as ATCC PTA-8287, described in US20100184079 or WO2008/002872); event EE-1 (aubergine, insect control, not filed, described in WO2007/091277); event FI117 (maize, herbicide tolerance, filed as ATCC 209031, described in US2006059581 or WO1998/044140); event GA21 (maize, herbicide tolerance, filed as ATCC 209033, described in US2005086719 or WO1998/044140); event GG25 (maize, herbicide tolerance, filed as ATCC 209032, described in US2005188434 or WO1998/044140); event GHB119 (cotton, insect control—herbicide tolerance, filed as ATCC PTA-8398, described in WO2008/151780); event GHB614 (cotton, herbicide tolerance, filed as ATCC PTA-6878, described in US2010050282 or WO2007/017186); event GJ11 (maize, herbicide tolerance, filed as ATCC 209030, described in US2005188434 or WO1998/044140); event GM RZ13 (sugar beet, virus resistance, filed as NCIMB-41601, described in WO2010/076212); event H7-1 (sugar beet, herbicide tolerance, filed as NCIMB 41158 or NCIMB 41159, described in US2004172669 or WO2004/074492); event JOPLIN1 (wheat, fungus resistance, not filed, described in US2008064032); event LL27 (soya bean, herbicide tolerance, filed as NCIMB41658, described in WO2006/108674 or US2008320616); event LL55 (soya bean, herbicide tolerance, filed as NCIMB 41660, described in WO2006/108675 or US2008196127); event LLcotton25 (cotton, herbicide tolerance, filed as ATCC PTA-3343, described in WO2003013224 or US2003097687); event LLRICE06 (rice, herbicide tolerance, filed as ATCC-23352, described in US6468747 or WO2000/026345); event LLRICE601 (rice, herbicide tolerance, filed as ATCC PTA-2600, described in US20082289060 or WO2000/026356); event LY038 (maize, quality trait, filed as ATCC PTA-5623, described in US2007028322 or WO2005061720); event MIR162 (maize, insect control, filed as PTA-8166, described in US2009300784 or WO2007/142840); event MIR604 (maize, insect control, not filed, described in US2008167456 or WO2005103301); event MON15985 (cotton, insect control, filed as ATCC PTA-2516, described in US2004-250317 or WO2002/100163); event MON810 (maize, insect control, not filed, described in US2002102582); event MON863 (maize, insect control, filed as ATCC PTA-2605, described in WO2004/011601 or US2006095986); event MON87427 (maize, pollination control, filed as ATCC PTA-7899, described in WO2011/062904); event MON87460 (maize, stress tolerance, filed as ATCC PTA-8910, described in WO2009/111263 or US20110138504); event MON87701 (soya bean, insect control, filed as ATCC PTA-8194, described in US2009130071 or WO2009/064652); event MON87705 (soya bean, quality trait—herbicide tolerance, filed as ATCC PTA-9241, described in US20100080887 or WO2010/037016); event MON87708 (soya bean, herbicide tolerance, filed as ATCC PTA9670, described in WO2011/034704); event MON87754 (soya bean, quality feature, filed as ATCC PTA-9385, described in WO2010/024976); event MON87769 (soya bean, quality trait, filed as ATCC PTA-8911, described in US20110067141 or WO2009/102873); event MON88017 (maize, insect control—herbicide tolerance, filed as ATCC PTA-5582, described in US2008028482 or WO2005/059103); event MON88913 (cotton, herbicide tolerance, filed as ATCC PTA-4854, described in WO2004/072235 or US2006059590); event MON89034 (maize, insect control, filed as ATCC PTA-7455, described in WO2007/140256 or US2008260932); event MON89788 (soya bean, herbicide tolerance, filed as ATCC PTA-6708, described in US2006282915 or WO2006/130436); event MS11 (oilseed rape, pollination control—herbicide tolerance, filed as ATCC PTA-850 or PTA-2485, described in WO2001/031042); event MS8 (oilseed rape, pollination control—herbicide tolerance, filed as ATCC PTA-730, described in WO2001/041558 or US2003188347); event NK603 (maize, herbicide tolerance, filed as ATCC PTA-2478, described in US2007-292854); event PE-7 (rice, insect control, not filed, described in WO2008/114282); event RF3 (oilseed rape, pollination control—herbicide tolerance, filed as ATCC PTA-730, described in WO2001/041558 or US2003188347); event RT73 (oilseed rape, herbicide tolerance, not filed, described in WO2002/036831 or US2008070260); event T227-1 (sugar beet, herbicide tolerance, not filed, described in WO2002/44407 or US2009265817); event T25 (maize, herbicide tolerance, not filed, described in US2001029014 or WO2001/051654); event T304-40 (cotton, insect control—herbicide tolerance, filed as ATCC PTA-8171, described in US2010077501 or WO2008/122406); event T342-142 (cotton, insect control, not filed, described in WO2006/128568); event TC1507 (maize, insect control—herbicide tolerance, not filed, described in US2005039226 or WO2004/099447); event VIP1034 (maize, insect control—herbicide tolerance, filed as ATCC PTA-3925, described in WO2003/052073); event 32316 (maize, insect control—herbicide tolerance, filed as PTA-11507, described in WO2011/084632); event 4114 (maize, insect control—herbicide tolerance, filed as PTA-11506, described in WO2011/084621).
The plants listed can be treated in accordance with the invention in a particularly advantageous manner with the inventive active ingredient mixture. The preferred ranges stated above for the mixtures also apply to the treatment of these plants. Particular emphasis is given to the treatment of plants with the mixtures specifically mentioned in the present text.
The control of animal pests, especially of nematodes, by treating the seed of plants has been known for a long time and is the subject of continual improvements. However, in the treatment of seed, a number of problems are encountered which cannot always be resolved in a satisfactory manner. Thus, it is desirable to develop methods for protecting the seed and the germinating plant which at least significantly reduce, or make superfluous, the additional application of crop protection agents after sowing or after the emergence of the plants. It is additionally desirable to optimize the amount of active ingredient employed in such a way as to provide maximum protection for the seed and the germinating plant from attack by animal pests, especially nematodes, but without damaging the plant itself by the active ingredient used. In particular, methods for the treatment of seed should also take into consideration the intrinsic insecticidal properties of transgenic plants in order to achieve optimum protection of the seed and the germinating plant with a minimum of crop protection agents being employed.
The present invention therefore also relates especially to a method for the protection of seed and germinating plants from attack by animal pests, especially by nematodes, and also to a method for increasing yields, by treating the seed with an inventive composition.
The invention likewise relates to the use of the inventive compositions for the treatment of seed for protecting the seed and the germinating plant from animal pests, especially from nematodes, and also for increasing yields.
The invention further relates to seed which has been treated with an inventive composition for protection from animal pests, especially nematodes.
One of the advantages of the present invention is that the particular systemic properties of the inventive compositions mean that treatment of the seed with these compositions not only protects the seed itself, but also the resulting plants after emergence, from animal pests, especially nematodes. In this manner, the immediate treatment of the crop at the time of sowing or shortly thereafter can be dispensed with.
It is also considered to be advantageous that the inventive mixtures can also be used for transgenic seed in particular.
Formulations
The active ingredient combinations can be converted to the customary formulations such as solutions, emulsions, wettable powders, suspensions, powders, dusts, pastes, soluble powders, granules, suspension-emulsion concentrates, natural and synthetic materials impregnated with active ingredient, and microencapsulations in polymeric materials, for the foliar and soil applications.
These formulations are produced in a known manner, for example by mixing the active ingredients with extenders, that is, liquid solvents and/or solid carriers, optionally with the use of surfactants, that is, emulsifiers and/or dispersants, and/or foam formers.
If the extender used comprises water, it is also possible, for example, to use organic solvents as cosolvents. The following are essentially suitable as liquid solvents: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example mineral oil fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulfoxide, and water.
Suitable solid carriers are:
for example ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals such as highly disperse silica, alumina and silicates; suitable solid carriers for granules are: for example crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, or else synthetic granules of inorganic and organic meals, and granules of organic material such as sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam formers are: for example nonionic and anionic emulsifiers such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulfonates, alkyl sulfates, arylsulfonates, or else protein hydrolysates; suitable dispersants are: for example lignosulfite waste liquors and methylcellulose.
Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, or else natural phospholipids such as cephalins and lecithins and synthetic phospholipids can be used in the formulations. Other possible additives are mineral and vegetable oils.
It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyes such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.
The formulations generally contain between 0.1 and 95 wt % of active ingredient, preferably between 0.5 and 90%.
The inventive active ingredient combinations may be present in commercially standard formulations and in the use forms, prepared from these formulations, as a mixture with other active ingredients, such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth-regulating substances or herbicides. The insecticides include, for example, phosphates, carbamates, carboxylates, chlorinated hydrocarbons, phenylureas and substances produced by microorganisms, etc.
Mixing with other known active ingredients such as herbicides or with fertilizers and growth regulators is also possible.
When used as insecticides, the inventive active ingredient combinations may additionally be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with synergists. Synergists are compounds which enhance the action of the active ingredients, without it being necessary for the synergist added to be active itself.
The active ingredient content of the use forms prepared from the commercially available formulations may vary within wide limits. The active ingredient concentration of the use forms may be from 0.0000001 to 95 wt % of active ingredient, preferably between 0.0001 and 50 wt %.
The compounds are employed in a customary manner appropriate for the use forms.
Use Forms
When the active ingredients of the invention are used for controlling animal pests, more particularly nematodes, the application rates may be varied within a relatively wide range, depending on the mode of application. The application rate of the active ingredients of the invention

    
    
        when treating parts of plants, such as leaves, is as follows: from 0.1 to 10 000 g/ha, preferably from 10 to 1000 g/ha, more preferably from 50 to 300 g/ha (if applied by watering or dripping, the application rate may even be reduced, especially if inert substrates such as rock wool or perlite are used);
        in the treatment of seed is as follows: from 2 to 200 g per 100 kg of seed, preferably from 3 to 150 g per 100 kg of seed, more preferably from 2.5 to 25 g per 100 kg of seed, very preferably from 2.5 to 12.5 g per 100 kg of seed;
        for soil treatment is as follows: from 0.1 to 10 000 g/ha, preferably from 1 to 5000 g/ha.
    
    


These application rates are given only by way of example and without limitation for the purposes of the invention.
The active ingredients and/or compositions of the invention can therefore be used to protect plants, within a certain period of time after treatment, against infestation by animal pests, more particularly nematodes. The period of time within which protection of the plant is brought about extends in general over 1 to 28 days, preferably over 1 to 14 days, more preferably over 1 to 10 days, very preferably over 1 to 7 days after the treatment of the plants with the active ingredients, or to up to 200 days after seed treatment.
Foliar Applications
Foliar application is understood to mean the inventive treatment of the plants and plant parts with the active ingredients directly or by action on the environment, habitat or storage space thereof by the customary treatment methods, for example by dipping, spraying, vaporizing, nebulizing, scattering, painting and injecting. Plant parts are understood to mean all above-ground and below-ground parts and organs of the plants, such as shoot, leaf, flower and root, examples including leaves, needles, stems, stalks, flowers, fruit-bodies, fruits and seeds, and also roots, tubers and rhizomes. The plant parts also include harvested plants and vegetative and generative propagation material, for example seedlings, tubers, rhizomes, runners and seeds.
Soil Application
Soil application is understood to mean the control of insects and/or spider mites and/or nematodes by drenching pesticides onto the soil, incorporating them into the soil and in irrigation systems as droplet application onto the soil. Alternatively, the inventive active ingredient combinations can be introduced into the site of the plants in solid form (for example in the form of granules). In the case of paddy rice crops, this may also be accomplished by metering the inventive active ingredient combinations in a solid application form (for example as a granule) into a flooded paddy field.
The invention relates to these application forms to natural (soil) or artificial substrates (for example rock wool, glass wool, quartz sand, pebbles, expanded clay, vermiculite), outdoors or in closed systems (e.g. greenhouses or under film cover) and in annual (e.g. vegetables, potatoes, cotton, beet, ornamental plants) or perennial crops (e.g. citrus plants, fruit, tropical crops, spices, nuts, vines, conifers and ornamental plants). It is additionally possible to deploy the active ingredients by the ultra-low-volume method or to inject the active ingredient formulation or the active ingredient itself into the soil.
Seed Treatment
The inventive active ingredient combinations are suitable especially for protection of seed of any plant variety which is used in agriculture, in greenhouses, in forests or in horticulture from the aforementioned animal pests, especially from nematodes. More particularly, the seed is that of cereals (such as wheat, barley, rye, millet and sorghum, and oats), maize, cotton, soya, rice, potatoes, sunflower, beans, coffee, beet (e.g. sugar beet and fodder beet), peanut, vegetables (such as tomato, cucumber, onions and lettuce), lawns and ornamental plants. Of particular significance is the treatment of the seed of cereals (such as wheat, barley, rye and oats), maize and rice, and the treatment of cotton and soya seed.
In the context of the present invention, the inventive composition is applied on its own or in a suitable formulation to the seed. Preferably, the seed is treated in a state in which it is sufficiently stable that the treatment does not cause any damage. In general, treatment of the seed may take place at any point in time between harvesting and sowing. Typically, the seed used has been separated from the plant and freed from cobs, shells, stalks, coats, hairs or the flesh of the fruits. For example, it is possible to use seed which has been harvested, cleaned and dried to a moisture content of less than 15 wt %. Alternatively, it is also possible to use seed which, after drying, has been treated, for example, with water and then dried again.
When treating the seed, it generally has to be ensured that the amount of the inventive composition applied to the seed and/or the amount of further additives is selected such that the germination of the seed is not adversely affected, and that the resulting plant is not damaged. This must be borne in mind in particular in the case of active ingredients which may exhibit phytotoxic effects at certain application rates.
The inventive active ingredient combinations/compositions can be applied directly, i.e. without comprising any further components and without having been diluted. In general, it is preferable to apply the compositions to the seed in the form of a suitable formulation. Suitable formulations and methods for the treatment of seed are known to the person skilled in the art and are described, for example, in the following documents: U.S. Pat. No. 4,272,417 A, U.S. Pat. No. 4,245,432 A, U.S. Pat. No. 4,808,430 A, U.S. Pat. No. 5,876,739 A, US 2003/0176428 A1, WO 2002/080675 A1, WO 2002/028186 A2.
The active ingredient combinations usable in accordance with the invention can be converted to the customary seed dressing product formulations such as solutions, emulsions, suspensions, powders, foams, slurries and other coating compositions for seed, and ULV formulations.
These formulations are prepared in the known manner by mixing the active ingredients or active ingredient combinations with customary additives, for example customary extenders and also solvents or diluents, dyes, wetters, dispersants, emulsifiers, antifoams, preservatives, secondary thickeners, adhesives, gibberellins, and also water.
The colorants which may be present in the seed dressing product formulations usable in accordance with the invention are all colorants which are customary for such purposes. Both pigments, which are sparingly soluble in water, and colorants, which are soluble in water, may be used. Examples of dyes include those known by the names Rhodamine B, C.I. Pigment Red 112 and C.I. Solvent Red 1.
The wetters which may be present in the seed dressing product formulations usable in accordance with the invention are all substances which are conventionally used for the formulation of active agrochemical ingredients and for promoting wetting. Alkylnaphthalenesulfonates, such as diisopropyl- or diisobutylnaphthalenesulfonates, can be used with preference.
Useful dispersants and/or emulsifiers which may be present in the seed dressing product formulations usable in accordance with the invention are all nonionic, anionic and cationic dispersants which are conventionally used for the formulation of active agrochemical ingredients. Nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants can be used with preference. Suitable nonionic dispersants include, in particular, ethylene oxide/propylene oxide block polymers, alkylphenol polyglycol ethers and tristryrylphenol polyglycol ethers, and their phosphated or sulfated derivatives. Suitable anionic dispersants are, in particular, lignosulfonates, polyacrylic acid salts and arylsulfonate/formaldehyde condensates.
The antifoams which may be present in the seed dressing product formulations usable in accordance with the invention are all foam-suppressing substances conventionally used for the formulation of active agrochemical ingredients. Silicone antifoams and magnesium stearate can be used with preference.
The preservatives which may be present in the seed dressing product formulations usable in accordance with the invention are all substances which can be employed in agrochemical compositions for such purposes. Examples include dichlorophen and benzyl alcohol hemiformal.
The secondary thickeners which may be present in the seed dressing product formulations usable in accordance with the invention are all substances which can be employed in agrochemical compositions for such purposes. Cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and finely divided silica are preferred.
The adhesives which may be present in the seed dressing product formulations usable in accordance with the invention are all customary binders which can be employed in seed dressing products. Preference is given to polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose.
The gibberellins which may be present in the seed dressing product formulations usable in accordance with the invention are preferably the gibberellins A1, A3 (=gibberellic acid), A4 and A7, particular preference being given to using gibberellic acid. The gibberellins are known (cf. R. Wegler “Chemie der Pflanzenschutz- and Schadlingsbekampfungsmittel” [Chemistry of Plant Protectants and Pesticides], Vol. 2, Springer Verlag, 1970, pp. 401-412).
The seed dressing product formulations usable in accordance with the invention can be employed either directly or after preceding dilution with water for the treatment of a wide range of seeds. For instance, the concentrates or the formulations obtainable therefrom by dilution with water can be used to dress the seed of cereals, such as wheat, barley, rye, oats and triticale, and the seed of maize, rice, rape, peas, beans, cotton, soya, sunflowers and beet, or else a wide variety of different vegetable seeds. The seed dressing product formulations usable in accordance with the invention or the dilute preparations thereof can also be used to dress seed of transgenic plants. In this context, additional synergistic effects may also occur as a consequence of the interaction with the substances formed by expression.
Useful apparatus which can be used to treat seed with the seed dressing product formulations usable in accordance with the invention, or with the preparations prepared therefrom by addition of water, is all mixing apparatus which can typically be used to dress seed. Specifically, the seed dressing procedure is to place the seed into a mixer, add the amount of seed dressing product formulation desired in each case, either as such or after preceding dilution with water, and mix until the formulation has been distributed homogeneously on the seed. If appropriate, this is followed by a drying process.
The application rate of the seed dressing product formulations usable in accordance with the invention can be varied within a relatively wide range. It is guided by the particular content of the active ingredients in the formulations and by the seed. The application rates of the active ingredient combinations are generally between 0.001 and 50 g per kilogram of seed, preferably between 0.01 and 25 g per kilogram of seed.
Calculation Formula for the Mortality of a Combination of Two Active Ingredients
The anticipated effect of a given combination of two active ingredients may be calculated (cf. Colby, S. R., “Calculating Synergistic and Antagonistic Responses of Herbicide Combinations”, Weeds 15, pages 20-22, 1967) as follows:

    
    
        if
        X is the mortality, expressed in % of the untreated control, when active ingredient A is used in an application rate of m ppm, or m g/ha
        Y is the mortality, expressed in % of the untreated control, when active ingredient B is used in an application rate of n ppm, or n g/ha
        E is the mortality, expressed in % of the untreated control, when active ingredients A and B are used at application rates of m and n ppm or of m and n g/ha,
        then
    
    






  E
  =
  
    X
    +
    Y
    -
    
      
        
          X
          ·
          Y
        
        100
      
      .
    
  




If the actual insecticide mortality is greater than calculated, then the combination is superadditive in its kill—that is, there is a synergistic effect. In this case the mortality actually observed must be greater than the value for the expected mortality (E) calculated on the basis of the formula given above.
Example 1
Myzus Test (Spray Treatment)
Solvent: 78 parts by weight of acetone


    
    
        1.5 parts by weight of dimethylformamide

Emulsifier: 0.5 part by weight of alkylaryl polyglycol ether

    
    


A suitable preparation of active ingredient is prepared by mixing one part by weight of active ingredient with the stated amounts of solvent and emulsifier and diluting the concentrate with emulsifier-containing water to the desired concentration. A suitable suspension of biological agent is prepared by dissolving the cells, spores or viruses in emulsifier-containing water in the desired concentration.
Chinese cabbage (Brassica pekinensis) leaf disks infested by all stages of the green peach aphid (Myzus persicae) are sprayed with an active ingredient and/or biological agent preparation in the desired concentration.
After the desired time, the effect in % is ascertained. Here, 100% means that all of the aphids have been killed; 0% means that no aphids have been killed. The mortality figures determined are used for calculation according to the Colby formula (see sheet 1).
In this test, the following combination of fluopyram with a further active ingredient or with a biological agent in accordance with the present specification gave a synergistically boosted activity in comparison to the substances employed individually:







TABLE 1







Myzus persicae test










Concentration



Active ingredient/biological agents
g ai/ha
Mortality in % after 1d












Fluopyram
1000
0



500
0


Imicyafos
67.5
0










Fluopyram + imicyafos

found*
calc.**



 1000 + 67.5 
100
0









Pyrethrum
100
80










Fluopyram + pyrethrum

found*
calc.**



1000 + 100 
100
80









Fluensulfone
2000
0










Fluopyram + fluensulfone

found*
calc.**



 500 + 2000
 90
0


Paecilomyces lilacinus strain 251
5000
0



Fluopyram + Paecilomyces lilacinus strain 251

found*
calc.**



1000 + 5000
 70
0









Bacillus amyloliquefaciens strain FZB 42
2000
0










Fluopyram + Bacillus amyloliquefaciens

found*
calc.**



1000 + 2000
 90
0









Cydia pomonella granulosis virus (CpGV)
1000
0










Fluopyram + Cydia pomonella granulosis virus (CpGV)

found*
calc.**



1000 + 1000
 70
0









Fluopyram
1000
0



500
0


Bacillus thuringiensis subsp. tenebrionis
1000
0










Fluopyram + Bacillus thuringiensis subsp. tenebrionis

found*
calc.**



1000 + 1000
 80
0


Azadirachtin

100
0


Fluopyram + azadirachtin

found*
calc.**



1000 + 100 
 70
0









Metschnikowia fructicola
1000
0










Fluopyram + Metschnikowia fructicola

found*
calc.**



 500 + 1000
 90
0





*found = insecticidal action found,


**calc. = action calculated by the Colby formula






Example 2
Spodoptera frugiperda Test (Spray Treatment)
Solvent: 78.0 parts by weight of acetone


    
    
        1.5 parts by weight of dimethylformamide

Emulsifier: 0.5 part by weight of alkylaryl polyglycol ether

    
    


A suitable preparation of active ingredient is prepared by mixing one part by weight of active ingredient with the stated amounts of solvent and emulsifier and diluting the concentrate with emulsifier-containing water to the desired concentration. Maize (Zea mays; corn) leaf disks are sprayed with an active ingredient preparation of the desired concentration and, after drying off, are populated with caterpillars of the army worm (Spodoptera frugiperda).
After the desired time, the effect in % is ascertained. Here, 100% means that all of the caterpillars have been killed, 0% means that no caterpillar has been killed. The mortality figures determined are used for calculation according to the Colby formula (see sheet 1).
In this test, the following combination of fluopyram and a further active ingredient in accordance with the present specification gave a synergistically boosted activity in comparison to the active ingredients employed individually:







TABLE 2







Spodoptera frugiperda test











Active ingredient/
Concentration
Mortality in %



biological agents
g ai/ha
after 2d







Fluopyram
1000
 0



Pyrethrum
 100
33












Fluopyram + pyrethrum

found*
calc.**




1000 + 100
50
33







*found = insecticidal action found,



**calc. = action calculated by the Colby formula






Example 3
Seed Treatment—Cotton Emergence Test
Seed of cotton (Gossypium hirsutum) is mixed with the desired amount of active ingredient and spores and also water. After drying, 25 seed grains in each case are sown in pots filled with sandy loam.
After 2 days, the effect in % is ascertained on the basis of the cotton plants that have emerged.
The following combinations of fluopyram and biological agents gave a better emergence rate in comparison to the substances employed individually and to the untreated control:







TABLE 3







Cotton emergence











Emergence in % 




in comparison 



Concentration
to untreated


Active ingredient/biological agents
g ai/kg seed
control












Control (untreated seed)

100


Fluopyram
1
133



0.5
100


Bacillus subtilis strain GB 03
0.078
158


Fluopyram + B. subtilis strain GB 03
 0.5 + 0.078
288


Bacillus amyloliquefaciens strain FZB 42
0.15
163



0.075
158


Fluopyram + B. amyloliquefaciens strain
 1.0 + 0.15
225


FZB 42
 0.5 + 0.075
221





*found = insecticidal action found,


**calc. = action calculated by the Colby formula






Example 4
Meloidogyne incognita Test
Solvent: 125.0 parts by weight of acetone
A suitable preparation of active ingredient is prepared by mixing one part by weight of active ingredient with the stated amounts of solvent and diluting the concentrate with water to the desired concentration. A spore suspension is prepared by diluting the spores with water to the desired concentration.
Vessels are filled with sand, active ingredient solution, Meloidogyne incognita egg-and-larvae suspension, and lettuce seeds. The lettuce seeds germinate and the seedlings develop. The galls develop on the roots.
After the desired time, the nematicidal effect is determined on the basis of gall formation in %. Here, 100% means that no galls have been found; 0% means that the number of galls on the treated plants corresponds to the untreated control. The figures ascertained are used for calculation according to the Colby formula (see sheet 1).
In this test, the following combination of fluopyram and biological agents in accordance with the present specification gave a synergistically boosted activity in comparison to the active ingredients employed individually:







TABLE 4







Meloidogyne incognita test










Concentration
Mortality in %


Active ingredient/biological agents
in ppm
after 21d












Fluopyram
0.0005
0


Metarhizium anisopliae strain F52
5
0










Fluopyram + M. anisopliae strain F52

found*
calc.**



0.0005 + 5
80
0





*found = insecticidal action found,


**calc. = action calculated by the Colby formula






Example 5
Glycine max—Growth Promotion in Combination with Mycorrhiza 
Seed of soya beans (Glycine max) is mixed with the desired amount of active ingredient in water. After drying, the seeds are sown in pots filled with sand and perlite (1:1). For inoculation with arbuscular mycorrhiza fungi, the sand-perlite mixture is mixed beforehand with the Mycorrhiza inoculum (AMykor GmbH; Germany) in a concentration of 25 ml/L. The seed is covered with 3 cm of Lecaton (expanded clay).
Over the following 44 days, the plants are cultivated in a greenhouse in good growth conditions. The pots are watered with a nutrient solution (Hoagland and Amon, 1950, half-concentrated solution) with a low phosphate concentration (20 μM).
The untreated control plants are cultured without arbuscular mycorrhiza fungi, but under the same conditions.
The growth-promoting effect on shoot and roots is ascertained via the weight of the fresh roots of the treated plant in comparison to the untreated control.
The following combination of active ingredient and biological agents gives increased root growth in comparison to the ingredients and agents applied individually, and to the control:







TABLE 5







Plant growth of soya bean











Root weight in % in


Active ingredient/
Concentration
comparison to untreated


biological agents
mg/seed grain
control












Control
—
100


Fluopyram
0.1
116.90


Arbuscular mycorrhiza fungus
—
133.21


Fluopyram + arbuscular 
0.1
137.91


mycorrhiza fungus

## Claims

1. An active ingredient combination comprising
synergistically effective amounts of:
(I-1) N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide of formula (I)




(fluopyram)
and/or an N-oxide thereof and
(II) Paecilomyces lilacinus strain 251,
wherein the sole active components in the combination are fluopyram and Paecilomyces lilacinus strain 251.

2. A method for controlling one of more animal pests, comprising causing an active ingredient combination as defined in claim 1, to act on leaves, flowers, stems and/or seed of a plant to be protected, on an animal pest and/or a habitat thereof, and/or on soil.

3. A process for preparing a nematicidal composition, comprising mixing an active ingredient combination as defined in claim 1, with at least one extender and/or surfactant.

4. A composition comprising an active ingredient combination of claim 1, for controlling one or more animal pests.

5. A seed comprising an active ingredient combination as defined in claim 1.

6. A method for treating seed comprising contacting said seed with a combination as claimed in claim 1.

7. A method for treating soil and/or an artificial substrate comprising contacting said soil and/or substrate with a combination as claimed in claim 1.

8. The active ingredient combination as defined in claim 1, wherein the weight ratio of (I-1) to said Paecilomyces lilacinus strain 251 is 500:1 to 1:500.

9. The active ingredient combination as defined in claim 1, wherein the weight ratio of (I-1) to said Paecilomyces lilacinus strain 251 is 125:1 to 1:125.

10. The active ingredient combination as defined in claim 1, wherein the weight ratio of (I-1) to said Paecilomyces lilacinus strain 251 is 25:1 to 1:25.

11. A method for controlling nematodes, comprising contacting soil with a combination as claimed in claim 1.