Exhibit 3.1
 AMENDED
AND RESTATED
CERTIFICATE OF INCORPORATION OF
CLOVIS ONCOLOGY, INC.
 Corporation
   DGCL
   ARTICLE I
 Corporation
 ARTICLE II
  ARTICLE III
  ARTICLE IV




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Series A-1 Preferred Stock Series A-2 Preferred Stock Series B Preferred Stock Series C Preferred
Stock
  ARTICLE V
  1. Definitions Article V
 (a) Conversion Price
 (b) Convertible Securities
 (c) Corporation
 (d) Distribution Section 2(d)
 (e) Dividend Rate
 (f) Liquidation Preference
 (g) Options
 -2-




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(h) Original Issue Price
 (i) Preferred Stock
 (j) Purchase Agreement
 (k) Recapitalization
 2. Dividends
 (a) Preferred Stock pro
rata, pari passu
 (b) Additional Dividends Section 3 Section 2(a) Section 4(a)
 (c) Non-Cash Distributions Section 2
 -3-




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(d) Consent to Certain Distributions
 (e) Waiver of Dividends
 3. Liquidation Rights
 (a) Liquidation Preference Section 3(b)(ii) Section
3(a) pro rata Section 3(a)
 (b) Remaining Assets
 (i) Section 3(b)(ii) Section 3(a) pro rata provided however
 -4-




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Section 3
 (ii) Section 3 Section 3(b)(ii) Sections 3(a) Section 3(b)(i) Section 3(b)(ii) Section 3(a) Section
3(b)(i)
 (c) Reorganization Section 3
 (d) Valuation of Non-Cash Consideration
 -5-




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(i)
 (ii)
  Section 3(d) trading day closing prices closing bid prices
 4. Conversion Conversion Rights
 (a) Right to Convert Conversion Rate Section 4
 (b) Automatic Conversion
 (i) Upon a Qualified IPO or Consent of Preferred Holders Securities Act provided
 -6-




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provided further Qualified IPO Automatic
Conversion Event
 (ii) Special Automatic Conversion
 (1) Section 4(b)(ii)
 Mandatory Pro Rata Share
 Participating Holder
 Non-Participating Holder
 Partially-Participating Holder
 Qualified Financing
 Series A-2 Qualified Financing
 -7-




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Series B Qualified Financing
 Series C Qualified Financing
 (2) Effect of Non-Participation
   (3) Assigning Holder Successor Holder provided however Successor Holder
 -8-




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Section 4(b)(ii)(2)
 (4) Section 4(b)(ii)(2)
 (5) Section 4(b)(ii) Special Conversion
Event
 (6)
 (c) Mechanics of Conversion
 -9-




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provided however provided further however
 provided however
 (d) Adjustments to Conversion Price for Diluting Issues
 -10-




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(i) Special Definition Section 4(d) Additional Shares of
Common Section 4(d)(iii)
 (1)
 (2)
 (3)
 (4) Sections 4(e) 4(f) (g)
 (5)
 (6) provided
 (7)
 (8)
 (9)
 -11-




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(10)
 (ii) No Adjustment of Conversion Price Section 4(d)(iv)
 (iii) Deemed Issue of Additional Shares of Common
 (1)
 (2) Section 4(d) Sections 4(e) 4(f) 4(g)
 (3)
 -12-




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(4)
  Section 4(d)(iv)
 (5) Section 4(d)(iii)
 (iv) Adjustment of Conversion Price Upon Issuance of Additional Shares of Common Section 4(d)(iii)
 -13-




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Section 4(d)(iv)
 (v) Determination of Consideration Section 4(d)
 (1) Cash and Property
    (2) Options and Convertible Securities Section
4(d)(iii)
   (e) Adjustments for Subdivisions or Combinations of Common Stock
 -14-




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(f) Adjustments for Subdivisions or Combinations of Preferred Stock
 (g) Adjustments for Reclassification, Exchange and Substitution Section 3 Section 3
 (h) Certificate as to Adjustments Section 4
 (i) Waiver of Adjustment of Conversion Price
 -15-




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(j) Notices of Record Date
 (i)
 (ii)
 (iii) Section 3(c)
    (k) Reservation of Stock Issuable Upon Conversion
 5. Voting
 (a) Restricted Class Voting
 -16-




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(b) No Series Voting
 (c) Preferred Stock
 (d) Election of Directors Preferred Directors
 (e) Common Stock
 (f) Change in Authorized Common Stock
 6. Amendments and Changes
 -17-




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(a)
 (b)
 (c)
 (d) Section 2(d)
 (e)
 (f) Section 3(c)
 (g)
 (h)
 (i)
 (j) provided
 -18-




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(k)
 7. Notices Article V
 8. No Reissuance of Preferred Stock
 ARTICLE VI
  ARTICLE VII
  ARTICLE VIII
  ARTICLE IX
  ARTICLE X
 DGCL Proceeding
 -19-




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ARTICLE XI
  ARTICLE XII
 Covered Person Specified Opportunity Fund
 -20-




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/s/ Patrick J. MahaffyPatrick J. Mahaffy,President and Chief Executive Officer -21-




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CERTIFICATE OF AMENDMENT
 TO THE
 AMENDED AND RESTATED
 CERTIFICATE OF INCORPORATION
 OF
 CLOVIS ONCOLOGY, INC.
  THE UNDERSIGNED Corporation DGCL
 FIRST
 SECOND
 THIRD
 FOURTH
 The total number of shares of stock that the Corporation shall have authority to
issue is 97,922,093 shares, consisting of 58,000,000 shares of Common Stock, $0.001
par value per share, and 39,922,093 shares of Preferred Stock, $0.001 par value per
share. The Preferred Stock will be issued in four series. The first Series of
Preferred Stock shall be designated Series A-1 Preferred Stock and shall consist of
5,044,828 shares. The second Series of Preferred Stock shall be designated Series A-2
Preferred Stock and shall consist of 5,044,828 shares. The third Series of Preferred
Stock shall be designated Series B Preferred Stock and shall consist of 10,919,540
shares. The fourth Series of Preferred Stock shall be designated Series C Preferred
Stock and shall consist of 18,912,897 shares.




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IN WITNESS WHEREOF
 /s/ Patrick J. MahaffyName:
    Patrick J. MahaffyTitle:
    President and Chief Executive Officer -2-