Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 23000 I DP Barcode 0415989 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

DATE: 8 November 2013 

SUBJECT: Kasugamycin. REVISED Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessment for the Section 3 Registration Action 

Associated with Food/Feed Use ofthe Fungicide on Fruiting Vegetables (Group 

8-10), Porne Fruits (Group 11-10), and Walnuts. 

PC Code: 230001 

Decision Number: 427886 

Petition Number: OF7689 

DP Barcode: D415989 

Registration Number: 66330-404 

Regulatory Action: Section 3 

Risk Assessment Type: Dietary Case Number: 7045 

TXR Number: NA CAS Number: 6980-18-3 (19408-46-9, HCl salt) 

MRID Number: NA 40CFR: §180.614 

FROM: 

THRU: 

TO: 

and 

Ri

William 

sk Assessment 

T. Drew, 

Branch 

Chemist 

II 

~ (RAB2) 

Health Effects Division (HED), 7509P 

Douglas Dotson, PhJ?, Che~~ A· ~;e-JQ1c.) Torn Bloem, Chern~~~ Dietary Exposure Science Advisory Council (DESAC) 

HED, 7509P 

William T. Drew, Chemist and Risk Assessor 

RAB2/HED, 7509P 

Shaunta Hill and Hope Johnson, RM Team 21 

Fungicide Branch (FB) 

Registration Division (RD), 7505P 

Page 1 of9 
Kasugamycin 

Executive Summary 

Dietary Exposure and Risk Assessment 

PC Code 23 000 I DP Barcode 0415989 

A revised unre·fined chronic aggregate dietary (food and drinking water) exposure and risk 

assessment was conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID), Version 3.16. This software uses 2003-2008 food 

consumption data from the US Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analysis 

was performed to support the Section 3 request for kasugamycin use on fruiting vegetables group 

8-10, pome fruits group 11-1 0, and walnuts. All current and proposed uses of kasugamycin, as 

of the date of this memorandum, are included in this assessment. This revised dietary 

assessment was conducted to support HED's decision to harmonize the recommended US 

tolerances with the maximum residue limits (MRLs) selected by Canada's Pest Management 

Regulatory Agency (PMRA), which differ from BED's previously recommended tolerances. 

This memorandum was reviewed by two peer reviewers ofthe DESAC, per DESAC SOP 2012.1. 

Tolerance-level residues, and 100% crop treated (CT) were assumed for all raw agricultural 

commodities (RACs). DEEM default processing factors were used for all processed 

commodities except apple juice, for which the empirical factor from the processing study was 

used. The analysis included direct incorporation of modeled estimated kasugamycin residues in 

drinking water. The estimated drinking water concentration (EDWC) in surface water is 

0.001178 ppm for chronic exposure. This EDWC in surface water (0.00 1178 ppm) was used for 

the chronic dietary analysis since it is higher than the groundwater EDWC. 

Based on these highly conservative assumptions, chronic dietary risk estimates are less than or 

equal to 3.1% of the chronic population-adjusted dose ( cP AD) for all population subgroups. 

Children 1-2 years of age is the most highly-exposed subgroup, utilizing 3.1% of the cPAD, 

while the general US population utilizes <1.0% of the cPAD. Generally, HED is concerned 

when risk estimates exceed 100% of the PAD; therefore, all chronic dietary risk estimates are not 

of concern. 

An acute dietary endpoint was not selected for kasugamycin. As a result, acute dietary risk is not 

of concern. Kasugamycin has been classified by the Cancer Assessment Review Committee 

(CARC) as "not likely to be carcinogenic"; therefore, cancer risk is not of concern. 

1. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(the dose which HED has concluded will result in no unreasonable adverse health effects). This 

dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of 

Page 2 of9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 230001 DP Barcode 0415989 

departure (POD), such as the no observed adverse effect level (NOAEL) or lowest observed 

adverse effect level (LOAEL), divided by the requisite uncertainty and/or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA pesticides web site, Available Information on Assessing 

Exposure from Pesticides, A User's Guide (21 June 2000), which can be accessed via the web 

link http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf (or see SOP 99.6, 

dated 20 August 1999). 

The most recent dietary risk assessment for kasugamycin was conducted by W.T. Drew 

(0390458; 13 July 2012). This current document incorporates changes in the tolerance levels 

resulting from HED's decision to harmonize the recommended US tolerances with the MRLs 

selected by PMRA, which differ from HED's previously recommended tolerances. 

2. Residue Information 

This revised dietary assessment includes residue estimates supporting the requested Section 3 

registration of kasugamycin for use on fruiting vegetables (crop group 8-1 0), pome fruits (crop 

group 11-1 0), and walnuts. The residue of concern, for both tolerance enforcement and risk 

assessment, is the parent compound, kasugamycin. Residues resulting from use of kasugamycin 

are assumed to be at the tolerance levels now being recommended by HED (0.1 0 ppm in fruiting 

vegetables group 8-10,0.20 ppm in pome fruits group 11-10, and 0.04 ppm in walnuts), in 

harmonization with PMRA's MRLs. 

Default processing factors from DEEM 7.81 were used in the analysis, except for apple juice, for 

which the empirical factor from the processing study ( 1.5X) was used. 

A complete listing of the residues and processing factors used in the chronic dietary analysis is 

included in Attachment 1. 

Tolerances (without registration) have been established for kasugamycin ( 40CFR § 180.614) 

inion imported fruiting vegetables (crop group 8) at 0.04 ppm. A time-limited (Section 18) 

tolerance has also been established at 0.05 ppm for kasugamycin inion apples grown in 

Michigan, with expiration date of 31 December 2015. These tolerances will be superseded by 

those listed above when the proposed new uses are registered. 

Page 3 of9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 23000 I 

3. Percent Crop Treated Information 

DP Barcode 0415989 

The chronic assessment is highly conservative, and assumes that all crops with existing or 

currently requested uses bear residues of kasugamycin (in other words, 1 OO%CT). 

4. Drinking Water Data 

The drinking water residues used in this dietary risk assessment were provided by EFED 

(D376600; T. Dowen; 28 April 2011), and incorporated directly into the dietary assessment via 

entry into the food categories "water, direct, all sources" and "water, indirect, all sources." The 

EDWCs in surface water are 0.011562 ppm and 0.001178 ppm for acute and chronic scenarios, 

respectively. The EDWC in groundwater is 0.000116 ppm for all durations (see Table 1, below). 

The chronic surface water EDWC (0.001178 ppm) was used in the chronic djetary analysis 

because it is the higher of the chrome residues in water. 

The surface water EDWCs were obtained via exposure modeling which utilized the PRZM 

(Pesticide Root Zone Model) and EXAMS (EXposure Analysis Modeling System) models. 

These models and their descriptions are available at the EPA internet website via the web link, 

http://www.epa.gov/oppefedl/models/water/. The PRZMIEXAMS modeling was based on 

application of kasugamycin to tomatoes in Florida. 

TABLE! EDWCs for Kasugamycin, Plus Degradates Kasugamycinic Acid and Kasuganobiosamine. 

Crop I Acute Exposure (ppm) I Chronic Exposure (ppm) I Cancer Exposure (ppm) 

Surface Water (via PRZM/EXAMS) 

Tomato J 0.011562 I 0.001178* I 0.000602 

Ground Water (via SCI-GROW) 

Walnut I 0.0001 16 I 0.0001 16 I 0.0001 16 

* EDWC used m the chrome d1etary assessment. 

5. DEEM-FCID Program and Consumption Information 

The kasugamycin chronic dietary exposure assessment was conducted using DEEM-FCID 

(Version 3 .16) which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (such as apple pie) are 

linked to EPA-defined food commodities (such as apples, peeled fruit- cooked, 

fresh/unspecified, or baked; or wheat flour - cooked, fresh/unspecified, or baked) using publicly 

available recipe translation files developed jointly by USDA/ ARS and EPA. For chronic 

Page 4 of9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 23000 I DP Barcode 0415989 

exposure assessment, consumption data are averaged for the entire US population, and within 

population subgroups. However, for acute exposure assessment, they are retained as individual 

consumption events. Based on analysis of the 2003-2008 WWEIA consumption data, which 

took into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general US population, all 

infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, 

females 13-49, and adults 50-99 years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (such as orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day, and as a percent of the cPAD. This procedure 

is performed for each population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate, and summed to obtain a total daily pesticide exposure for 

a deterministic exposure assessment, or "matched" in multiple random pairings with residue 

values, and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aP AD on both a user (those who reported eating relevant 

commodities/food forms) and a per-capita (those who reported eating the relevant commodities 

as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk 

are reported for all dietary analyses, regardless of the degree of refinement (unrefined through 

highly refined). However, for unrefined or slightly refined analyses, significant differences in 

user versus per capita exposure and risk are identified, and noted in the risk assessment. 

6. Toxicological Information 

For detailed information, please refer to the human health risk assessment conducted for 

kasugamycin's use on fruiting vegetables, pome fruit, and walnuts (D376608; W.T. Drew; 13 

July 2012). The available database is considered of high quality, and is adequate for assessment 

of risk for the proposed uses. 

The chronic reference dose (cRfD) is 0.11 mg/kg/day. The NOAEL of 11 mg/kg/day is from the 

rat chronic toxicity/carcinogenicity study. This NOAEL was selected for the cRfD because it 

was of the appropriate route and duration, and is protective of effects seen in other studies. 

Although the testicular findings were not statistically significant compared to controls, these 

effects were selected as the basis for the study LOAEL because the incidence and severity were 

increased, and similar degenerative testicular effects were seen across species. The selected 

Page 5 of9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 230001 DP Barcode D41 5989 

endpoint is also protective of maternal and developmental toxicity (weight loss, decreased food 

consumption during dosing, abortion in one female, and decreased fetal weight) that was seen in 

the rabbit developmental toxicity range-finding study. No developmental toxicity was seen in 

the rat, and maternal toxicity was seen at 1000 mg/kg/day (200 mg/kg/day). 

The risk assessment team has confirmed that the selected doses and endpoints are appropriate to 

assess the currently proposed uses on fruiting vegetables, pome fruit, and walnuts. These doses 

and endpoints are summarized in Table 2, below. 

TABLE2 Summary of Kasugamycin Toxicological Doses and Endpoints for Use in Dietary Human 

Health Risk Assessments. 

Exposure Scenario Point of Uncertainty RID, PAD for Risk Study and Toxicological Effects 

Departure and FQPA Assessment 

Safety Factors 

Acute dietary Not required. Appropriate endpoints for this risk assessment scenario were not identified, 

(all populations) based on a lack of single-dose effects in the database. 

Chronic dietary NOAEL = 11 UFA= lOX Chronic RID = 0.11 Combined chronic 

(all populations, mg/kg/day UFH= lOX mg/kg/day toxicity/carcinogenicity study in 

including infants and FQPA SF= IX the rat. LOAEL = 116 

children, and females cPAD = O.Il mg/kg/day, based on testicular 

age 13 to 49) mg/kg/day atrophy and softening. 

Cancer Classification: "Not likely to be carcinogenic to humans." No oncogenic potential was 

(oral, dermal, noted in either the mouse oncogenicity or in the rat combined chronic/carcinogenicity 

inhalation) studies. Additionally, no mutagenic potential was noted in any of the mutagenicity studies. 

Pomt of Departure (POD) = a data pomt or estimated pomt denved from observed dose-response data, wh1ch IS used 

to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. UF = Uncertainty Factor. UFA =extrapolation from animal to human (interspecies). UFH = potential 

variation in sensitivity among members of the human population (intraspecies). FQPA SF= FQPA Safety Factor. 

NOAEL = No Observed Adverse Effect Level. LOAEL = Lowest Observed Adverse Effect Level. PAD = 

Population Adjusted Dose (a = acute, c =chronic). RID = Reference Dose. 

7. Results/Discussion 

As previously stated, for chronic assessments, HED is concerned when dietary risk exceeds 

100% of the cPAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the US 

population and the various population subgroups. 

The results of the chronic analysis are summarized in Table 3, below. The exposure estimates 

are considered very conservative because tolerance-level residues, and 100% CT, were assumed. 

As indicated in Table 3, the chronic risk estimates are not of concern for any of the population 

subgroups. 

Children 1-2 years of age is the most highly-exposed subgroup, utilizing 3.1% of the cPAD, 

while the general US population utilizes <1.0% of the cPAD. 

Page 6 of9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 230001 DP Barcode 0415989 

TABLE3 Sum mary of Chronic Dietary Exposure and Risk Estimates for Kasugamvcio. 

Population Subgroup* cPAD (mg/kg/day) Dietary Exposure Estimate %cPAD 

(Years of Age] (mg/kg/day) 

General US Population 0.11 0.000526 <1.0 

All Infants [ < 1] 0.11 0.001899 1.7 

Children [1-2) 0.11 0.003385 3.1 

Children [3-5] 0.11 0.002015 1.8 

Children [6-12] 0.11 0.000840 < 1.0 

Youth [13-19] 0.11 0.000367 <1.0 

Adults (20-49) 0.11 0.000295 < 1.0 

Adults [50-99] 0.11 0.000264 <1.0 

Females (13-49] 0.11 0.000299 <1.0 

* Values for the populatton subgroup w1th the highest risk are in bold type. 

8. Characterization of Inputs/Outputs 

This chronic dietary exposure and risk assessment is based on tolerance-level residues, default 

processing factors (except for the l.SX apple juice empirical factor, which is greater than the 

default factor of 1.3X), and assumes that all crops with either current or proposed kasugamycin 

tolerances are treated (1 OO%CT). These assumptions result in highly conservative, healthprotective estimates of dietary exposure and risk. 

9. Conclusions 

An unrefined chronic dietary assessment was conducted for all current and proposed uses of 

kasugamycin. There are no dietary exposure considerations that would preclude the 

establishment of tolerances for residues of kasugamycin inion fruiting vegetables group 8-10, 

pome fruits group 11-1 0, and walnuts. All population subgroups have risk estimates that are 

below HED's level of concern. HED is confident that the assessment does not underestimate 

risk to the general US population or any population subgroup. 

10. List of Attachments 

Attachment 1. Kasugamycin Residues Used for Chronic Dietary Exposure Estimates. 

Attachment 2. Summary of the Chronic Dietary Exposure and Risk Estimates for Kasugamycin. 

Page 7 of9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 23000 I DP Barcode 0415989 

Attachment 1. Kasugamycin Residues Used for Chronic Dietary Exposure Estimates. 

Fi lename: C: \ Do cumen t s a nd Se t tin g s\wdrew\My Do cume n t s \Kas ugamyc inDEEM110S13 I nput .ROS 

Chemi cal : Kasugamyc i n 

RfD(Chronic) : . 11 mg/ kg bw/day NOEL(Chron i c ): 0 mg/ kg bw/day 

RfD(Acute): 0 mg/ kg bw/day NOEL(Acute ): 0 mg/ kg bw/ day 

Date c reated /last mod i fied: 11 - 0 S- 20 13/0S: 01:45 Program ver . 3.16, 03 - 0S - d 

EPA Crop 

Code Grp Commodity Name 

11000 090 00 11 

11000 090 01 11 

1100007000 11 

11000100 00 11 

1100010001 11 

11000 08000 11 

11000 0S00 1 11 

110001100 0 11 

1100011001 11 

1100 1 2900 0 11 

0 80 2 14S OO O SBC 

110017 3500 11 

1 1002 1000 0 11 

080223 400 0 SBC 

11002 6600 0 11 

1100 267000 11 

110026800 0 11 

110026 8001 11 

110 0266001 11 

080 22 70 000 8B 

080 2271000 SB 

080 2271 001 8B 

08022 70 001 8B 

0802272 000 8BC 

080 22 73 000 SBC 

080 22 7200 1 SBC 

11003 10 000 11 

08013 74 000 SA 

OS01 375000 SA 

OS01 3SOOOO SA 

OS01 37 80 00 SA 

OS01 37S001 SA 

OS 0 137 90 00 SA 

OS0 1376 000 SA 

0801376 00 1 SA 

0801377000 SA 

OS01 37700 1 SA 

OS 01 375 001 SA 

14003 9 1000 1 4 

86 0 1000000 S6A 

S602 00000 0 S6B 

Apple, d ried 

Apple , dried - babyfood 

Ap p l e , fru it wi th peel 

App l e, jui c e 

App le, jui ce- babyfood 

Apple , p eel e d frui t 

App l e , peel ed fruit-bab yfood 

Appl e, s auc e 

Apple, s auc e - bab yfood 

c rabapple 

Eggp l a n t 

Goj i berry 

Lo quat 

Ok r a 

Pear 

Pe a r , d r i e d 

Pear , j u i c e 

Pear, j u i ce- babyfood 

Pear- babyfood 

Pepp er, bell 

Peppe r, b e ll, dri ed 

Pepper, b e ll, dri e d - babyf ood 

Pepper, bell - b abyf ood 

Pepp er, nonbe 11 

Pepper, nonbe l l, d r i ed 

Pepper, nonbell - babyf ood 

Qu i n c e 

Tomat i l l o 

Toma t o 

Toma t o, Tr ee 

Toma t o, d r ied 

Toma t o, d r ied- baby f o od 

Toma t o, jui c e 

Tomato, pas t e 

Tomat o , pas t e - babyfood 

Tomat o, puree 

Toma t o, puree- babyfood 

Toma t o - b abyf o od 

Wa l nut 

Wa t er, d i rec t , a l l sources 

Wate r , indirec t , all sourc e s 

Page 8 of9 

Def Re s 

(ppm) 

0. 200 000 

0.200000 

0 . 20 0000 

0 .200 00 0 

0.200000 

0. 20 0000 

0 .200000 

0 .200000 

0. 20 0000 

0.20 0000 

0. 100000 

0 . 1000 00 

0.20 0000 

0 .100000 

0.200 000 

0.200000 

0 . 20 0000 

0.2000 00 

0. 20 00 00 

0. 1000 00 

0 . 100000 

0 . 100 000 

0. 100 000 

0 . 100000 

0.100000 

0 . 100000 

0 . 200 000 

0 . 100 000 

0 .100 00 0 

0 .10000 0 

0 .1000 00 

0 .1000 00 

0 .1000 00 

0 . 100000 

0 . 100000 

0 . 100000 

0 .100 000 

0 . 100 000 

0.040000 

0. 0011 7S 

0 . 00 1178 

Adj.Fact ors 

#1 # 2 

s. ooo 

8 .000 

1 . 000 

1 . 500 

1 . 500 

1. 000 

1 .000 

1. 000 

1 . 000 

1. 000 

1 . 000 

1. 000 

1. 000 

1.000 

1. 000 

6.250 

1 .000 

1 .000 

l. 000 

l. 000 

1 . 000 

l. 000 

1 . 000 

1. 000 

1 .000 

1 . 000 

1 . 00 0 

1 . 000 

1 . 000 

l. 0 00 

1 4 . 300 

14 . 300 

1 . 500 

5 . 4 00 

5 . 40 0 

3 . 300 

3 . 300 

1 .000 

1 . 000 

1 .000 

1. 000 

1 . 00 0 

1. 000 

1 . 00 0 

1 . 000 

l. 000 

1 .000 

1 . 00 0 

1 . 00 0 

1 . 000 

1 . 000 

1. 0 00 

1 .000 

1 .000 

1 . 0 00 

1 . 0 00 

1 . 0 00 

1 . 0 00 

l. 000 

l. 0 00 

1 . 0 00 

l. 0 00 

1 . 0 00 

l. 0 00 

l. 0 00 

l. 0 00 

l. 000 

1. 00 0 

1. 00 0 

l. 00 0 

l. 00 0 

1.000 

1.000 

l. 00 0 

l. 000 

1. 00 0 

1. 00 0 

1 . 00 0 

1. 00 0 

1. 000 

l. 000 

l. 000 

Comme n t 

OF768 9 

OF768 9 

OF76 S9 

OF76 89 

OF768 9 

OF76 89 

OF7689 

OF7689 

OF76S9 

OF768 9 

OF76S9 

OF76 S9 

OF76S9 

OF7689 

OF7689 

OF7689 

OF7689 

OF768 9 

OF768 9 

OF76S9 

OF7689 

OF7689 

OF7689 

OF76S9 

OF76S9 

OF768 9 

OF76 8 9 

OF76S9 

OF76S9 

OF76S9 

OF76S9 

OF7 6S9 

OF7 6S9 

OF7689 

OF7689 

OF76S9 

OF76S9 

OF76S9 

OF7 6S9 

OF768 9 

OF76 8 9 
Kasugamycin 

Dietary Exposure and Risk Assessment 

PC Code 23000 I DP Barcode D415989 

Attachment 2. Summary of the Chronic Dietary Exposure and Risk Estimates for 

Kasugamycin. 

US EPA 

DEEM- FCID Chroni c analysis f o r KASUGAMYCIN 

Residue f i le name : C: \Documents and Settings\wdrew\My 

Documents\Kas ugamycinDEEM1 10813Input.R08 

Ver. 3. 16 , 03 - 08 - d 

NHANES 2003 - 2008 2 - day 

Adjustment f a c t or #2 NOT u sed. 

Analysi s Date 11- 08 - 201 3/08:04 : 33 Residue file dated: 11 - 08 - 2013/08:01 :45 

Reference dose (RfD, Chronic) = . 11 mg/kg bw/day 

Total exposure b y population subgroup 

Total Exposure 

Population 

Subgroup 

Tot al us Population 

Hi spanic 

Non - Hi sp- White 

Non- Hisp-Black 

Non-Hisp- Other 

Nursing Infant s 

Non-Nursing I nfants 

Fema l e 13+ PREG 

Children 1- 6 

Children 7 - 12 

Male 1 3 - 19 

Femal e 13 - 19/NP 

Male 20 + 

Fe male 20+/NP 

Seni ors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Child ren 3 - 5 

Child ren 6 - 12 

Youth 1 3 - 19 

Adul t s 20 - 4 9 

Adults 50- 99 

Female 13 - 49 

mg/kg 

body wt /day 

0 .000 526 

0 .000733 

0 . 000475 

0.000557 

0.000592 

0. 001128 

0.002243 

0. 000446 

0. 0 02400 

0.000740 

0 . 000365 

0.000364 

0 .000285 

0 . 000274 

0.000264 

0.001899 

0.000299 

0 . 003385 

0.002015 

0. 000840 

0. 0 0036 7 

0 . 000295 

0 . 000264 

0 . 000299 

Page 9 of9 

Percent of 

Rfd 

0. 5% 

0 . 7% 

0 . 4 % 

0 .5% 

0 . 5% 

1 . 0% 

2 . 0% 

0 .4% 

2 .2% 

0.7% 

0.3% 

0 . 3% 

0.3% 

0.2% 

0 . 2% 

1. 7% 

0 . 3% 

3 . 1% 

1. 8% 

0.8% 

0.3% 

0.3% 

0.2% 

0.3%