Exhibit 4.2


	
  

  	
  016570|
  003590|127C|RESTRICTED||4|057-423  THIS CERTIFIES THAT  is the owner of CUSIP DATED  COUNTERSIGNED AND REGISTERED:  COMPUTERSHARE
  TRUST COMPANY, N.A.  TRANSFER AGENT AND REGISTRAR,  FULLY-PAID AND NON-ASSESSABLE
  SHARES OF THE COMMON STOCK, $0.001 PAR VALUE PER SHARE, OF  ARYx Therapeutics, Inc. (hereinafter called the “Company”), transferable on the books of the Company in  person or by duly authorized
  attorney, upon surrender of this Certificate properly endorsed. This
  Certificate and  the shares represented hereby, are issued and shall be held
  subject to all of the provisions of the Certificate of  Incorporation, as amended, and
  the By-Laws, as amended, of the Company (copies of which are on file with the  Company and with the Transfer
  Agent), to all of which each holder, by acceptance hereof, assents. This  Certificate is not valid unless
  countersigned and registered by the Transfer Agent and Registrar.  Witness the facsimile
  seal of the Company and the facsimile signatures of its duly authorized
  officers.  COMMON STOCK  PAR VALUE $0.001  COMMON STOCK  THIS CERTIFICATE IS TRANSFERABLE IN  CANTON, MA AND JERSEY CITY, NJ  SEE REVERSE FOR CERTAIN
  DEFINITIONS  Certificate  Number  Shares  ARYx THERAPEUTICS, INC.  INCORPORATED UNDER THE LAWS OF THE
  STATE OF DELAWARE  Chairman of
  the Board  Secretary  By  AUTHORIZED SIGNATURE 043387 10 9 <<Month Day, Year>>  * s p e c i m e n * * * *  * * s p e c i m e n * * *  * * * s p e c i m e n * *  * * * * s p e c i m e n *  * * * * * s p e c i m e n  ****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen  **specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen**  **specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**  specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****  specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**sp  ecimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****sp  ecimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**spec  imen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****speci  men**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specim  en****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specim  en**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specime  ****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen  **specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen**  **specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**  specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****  specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**sp  ecimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****sp  ecimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**spec  imen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****speci  men**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specim  en****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specim  en**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specimen****specimen**specime  ***SPECIMEN***SPECIMEN  ***SPECIMEN***SPECIMEN  SPECIMEN * SPECIMEN * SPECIMEN  * SPECIMEN * SPECIMEN *  ZQ 000000

  














	
  

  	
  The following
  abbreviations, when used in the inscription on the face of this Certificate,
  shall be construed as though they were written out in full  according to applicable laws or
  regulations:  TEN
  COM - as tenants in common UNIF GIFT MIN ACT- . . . . . . . . . .Custodian .
  . . . . . . . . . . . . . .  TEN ENT - as tenants by the entireties under Uniform Gifts to
  Minors Act . . . . . . . . . . . . .  JT TEN - as joint tenants with right of survivorship UNIF TRF
  MIN ACT . . . . . . . . . . . . . . .Custodian (until age. . . ). . . . . . .
  . . . .  and
  not as tenants in common (Cust) (Minor)  under Uniform Transfers to Minors
  Act. . . . . . . . . .  (State)  Additional abbreviations may also be used though not in the
  above list.  For
  value received, ____________________________hereby sell, assign and transfer
  unto  __
  Shares  ____
  Attorney  Dated:
  ____________20__________________  Signature:
  ____________________________________________________________  Signature: ____________________________________________________________  Notice: The signature to this
  assignment must correspond with the name  as written upon the face of the
  Certificate, in every particular,  without alteration or enlargement, or any change whatever.  (Cust) (Minor)  (State)  PLEASE INSERT SOCIAL SECURITY OR
  OTHER IDENTIFYING NUMBER OF ASSIGNEE  (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL
  ZIP CODE, OF ASSIGNEE)  of the common stock represented by the within Certificate, and
  do hereby irrevocably constitute and appoint  to transfer the said stock on the
  books of the within-named Company with full power of substitution in the
  premises.  .  ARYx THERAPEUTICS, INC.  THE COMPANY WILL FURNISH WITHOUT
  CHARGE TO EACH STOCKHOLDER WHO SO REQUESTS, A SUMMARY OF THE POWERS,
  DESIGNATIONS,  PREFERENCES
  AND RELATIVE, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS
  OF STOCK OF THE COMPANY AND THE  QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES
  AND RIGHTS, AND THE VARIATIONS IN RIGHTS, PREFERENCES AND  LIMITATIONS DETERMINED FOR EACH
  SERIES, WHICH ARE FIXED BY THE CERTIFICATE OF INCORPORATION OF THE COMPANY,
  AS AMENDED, AND  THE
  RESOLUTIONS OF THE BOARD OF DIRECTORS OF THE COMPANY, AND THE AUTHORITY OF
  THE BOARD OF DIRECTORS TO DETERMINE  VARIATIONS FOR FUTURE SERIES. SUCH REQUEST MAY BE MADE TO THE
  OFFICE OF THE SECRETARY OF THE COMPANY OR TO THE TRANSFER  AGENT. THE BOARD OF DIRECTORS MAY
  REQUIRE THE OWNER OF A LOST OR DESTROYED STOCK CERTIFICATE, OR HIS LEGAL  REPRESENTATIVES, TO GIVE THE COMPANY
  A BOND TO INDEMNIFY IT AND ITS TRANSFER AGENTS AND REGISTRARS AGAINST ANY
  CLAIM THAT  MAY
  BE MADE AGAINST THEM ON ACCOUNT OF THE ALLEGED LOSS OR DESTRUCTION OF ANY
  SUCH CERTIFICATE.  Signature(s) Guaranteed: Medallion Guarantee Stamp  THE SIGNATURE(S) SHOULD BE
  GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (Banks,  Stockbrokers, Savings and Loan
  Associations and Credit Unions) WITH MEMBERSHIP IN AN APPROVED  SIGNATURE GUARANTEE MEDALLION
  PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15.