2008 Stock Plan, as amended



 Exhibit 10.2 

PRONAI THERAPEUTICS, INC. 

2008 STOCK PLAN 

1. PURPOSES OF THE PLAN. The purposes of this Plan are to attract and
retain the best available personnel for positions of substantial responsibility, to provide additional incentive to Employees, Directors and Consultants and to promote the success of the Company’s business. Options granted under the Plan may be
Incentive Stock Options or Nonstatutory Stock Options, as determined by the Administrator at the time of grant. Stock Purchase Rights may also be granted under the Plan. 

2. DEFINITIONS. As used herein, the following definitions shall apply: 

(a) “Administrator” means the Board or any of its Committees as shall be
administering the Plan in accordance with Section 4 hereof. 
 (b)
“Applicable Laws” means the requirements relating to the administration of stock option plans under U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or
quotation system on which the Common Stock is listed or quoted and the applicable laws of any other country or jurisdiction where Options or Stock Purchase Rights are granted under the Plan. 

(c) “Board” means the Board of Directors of the Company. 

(d) “Change in Control” means the occurrence of any of the following events: 

(i) Any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “beneficial
owner” (as defined in Rule 13d-3 of the Exchange Act), directly or indirectly, of securities of the Company representing fifty percent (50%) or more of the total voting power represented by the Company’s then outstanding voting
securities; or 
 (ii) The consummation of the sale or disposition by the Company of all or substantially all of the
Company’s assets; or 
 (iii) The consummation of a merger or consolidation of the Company with any other corporation,
other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the
surviving entity or its parent) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such surviving entity or its parent outstanding immediately after such merger or consolidation.

 The Administrator may, in its sole discretion and without Service Provider consent, amend the definition of “Change in
Control” to conform to the definition of “Change in Control” under Section 409A of the Code. 

  
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 (e) “Code” means the Internal Revenue Code of 1986, as amended.

 (f) “Committee” means a committee of Directors or of other individuals satisfying Applicable Laws
appointed by the Board in accordance with Section 4 hereof. 
 (g) “Common Stock” means the Common Stock
of the Company. 
 (h) “Company” means ProNAi Therapeutics, Inc., a Delaware corporation. 

(i) “Consultant” means any person who is engaged by the Company or any Parent or Subsidiary to render
consulting or advisory services to such entity. 
 (j) “Director” means a member of the Board. 

(k) “Disability” means total and permanent disability as defined in Section 22(e)(3) of the Code. 

(l) “Employee” means any person, including officers and Directors, employed by the Company or any Parent or
Subsidiary of the Company. Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient to constitute “employment” by the Company. 

(m) “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(n) “Fair Market Value” means, as of any date, the value of Common Stock determined as follows: 

(i) If the Common Stock is listed on any established stock exchange or a national market system, including without limitation the
Nasdaq National Market or The Nasdaq SmallCap Market of The Nasdaq Stock Market, its Fair Market Value shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such exchange or system on the day of
determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; 
 (ii) If
the Common Stock is regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high bid and low asked prices for the Common Stock on the day of determination; or 

(iii) In the absence of an established market for the Common Stock, the Fair Market Value thereof shall be determined in good faith by
the Administrator. 
 (o) “Incentive Stock Option” means an Option intended to qualify as an incentive stock
option within the meaning of Section 422 of the Code. 
 (p) “Nonstatutory Stock Option” means an Option
not intended to qualify as an Incentive Stock Option. 
 (q) “Option” means a stock option granted pursuant
to the Plan. 

  
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 (r) “Option Agreement” means a written or electronic agreement
between the Company and an Optionee evidencing the terms and conditions of an individual Option grant. Each Option Agreement is subject to the terms and conditions of the Plan. 

(s) “Optioned Stock” means the Common Stock subject to an Option or a Stock Purchase Right. 

(t) “Optionee” means the holder of an outstanding Option or Stock Purchase Right granted under the Plan. 

(u) “Parent” means a “parent corporation,” whether now or hereafter existing, as defined in
Section 424(e) of the Code. 
 (v) “Plan” means this 2008 Stock Plan. 

(w) “Restricted Stock” means Shares issued pursuant to a Stock Purchase Right or Shares of restricted stock
issued pursuant to an Option. 
 (x) “Restricted Stock Purchase Agreement” means a written agreement between
the Company and the Optionee evidencing the terms and restrictions applying to Shares purchased under a Stock Purchase Right. Each Restricted Stock Purchase Agreement is subject to the terms and conditions of the Plan and the notice of grant. 

(y) “Securities Act” means the Securities Act of 1933, as amended. 

(z) “Service Provider” means an Employee, Director or Consultant. 

(aa) “Share” means a share of the Common Stock, as adjusted in accordance with Section 12 below. 

(bb) “Stock Purchase Right” means a right to purchase Common Stock pursuant to Section 11 below. 

(cc) “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing, as defined in
Section 424(f) of the Code. 
 3. STOCK SUBJECT TO THE
PLAN. 
 (a) Subject to the provisions of Section 13 of the Plan, the maximum aggregate number of Shares that
may be subject to option and sold under the Plan is 2,300,000 Shares. In no event shall the number of Shares issued pursuant to Incentive Stock Options exceed 2,300,000 Shares. The Shares may be authorized but unissued, or reacquired Common Stock.

 (b) If an Option or Stock Purchase Right expires or becomes unexercisable without having been exercised in full, the unpurchased
Shares that were subject thereto shall become available for future grant or sale under the Plan (unless the Plan has terminated). However, Shares that have actually been issued under the Plan, upon exercise of either an Option


  
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or Stock Purchase Right, shall not be returned to the Plan and shall not become available for future distribution under the Plan, except that if Shares of Restricted Stock are repurchased by the
Company at their original purchase price, such Shares shall become available for future grant under the Plan. 
 4.
ADMINISTRATION OF THE PLAN. 
 (a) Administrator. The Plan shall be
administered by the Board or a Committee appointed by the Board, which Committee shall be constituted to comply with Applicable Laws. 

(b) Powers of the Administrator. Subject to the provisions of the Plan and, in the case of a Committee, the specific duties delegated
by the Board to such Committee, and subject to the approval of any relevant authorities, the Administrator shall have the authority in its discretion: 

(i) to determine the Fair Market Value; 

(ii) to select the Service Providers to whom Options and Stock Purchase Rights may from time to time be granted hereunder; 

(iii) to determine the number of Shares to be covered by each such award granted hereunder; 

(iv) to approve forms of agreement for use under the Plan; 

(v) to determine the terms and conditions of any Option or Stock Purchase Right granted hereunder. Such terms and conditions include,
but are not limited to, the exercise price, the time or times when Options or Stock Purchase Rights may be exercised (which may be based on performance criteria), any vesting acceleration or waiver of forfeiture restrictions, and any restriction or
limitation regarding any Option or Stock Purchase Right or the Common Stock relating thereto, based in each case on such factors as the Administrator, in its sole discretion, shall determine; 

(vi) to prescribe, amend and rescind rules and regulations relating to the Plan, including rules and regulations relating to sub-plans
established for the purpose of satisfying applicable foreign laws; 
 (vii) to allow Optionees to satisfy withholding tax
obligations by electing to have the Company withhold from the Shares to be issued upon exercise of an Option or Stock Purchase Right that number of Shares having a Fair Market Value equal to the minimum amount required to be withheld. The Fair
Market Value of the Shares to be withheld shall be determined on the date that the amount of tax to be withheld is to be determined. All elections by Optionees to have Shares withheld for this purpose shall be made in such form and under such
conditions as the Administrator may deem necessary or advisable; 
 (viii) to amend the terms of any one or more Options or Stock
Purchase Rights without the affected Service Provider’s consent if necessary to maintain the qualified status of such Option as an Incentive Stock Option or to bring an Option or Stock Purchase Right into compliance with Code Section 409A
and the related guidance thereunder; and 
 (ix) to construe and interpret the terms of the Plan and Options granted pursuant to the
Plan. 

  
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 (c) Effect of Administrator’s Decision. All decisions, determinations and
interpretations of the Administrator shall be final and binding on all Optionees. 
 5. ELIGIBILITY.
Nonstatutory Stock Options and Stock Purchase Rights may be granted to Service Providers. Incentive Stock Options may be granted only to Employees. 

6. LIMITATIONS. 

(a) Incentive Stock Option Limit. Each Option shall be designated in the Option Agreement as either an Incentive Stock Option or a
Nonstatutory Stock Option. However, notwithstanding such designation, to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options are exercisable for the first time by the Optionee during any
calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds $100,000, such Options shall be treated as Nonstatutory Stock Options. For purposes of this Section 6(a), Incentive Stock Options shall be taken into account in
the order in which they were granted. The Fair Market Value of the Shares shall be determined as of the time the Option with respect to such Shares is granted. 

(b) At-Will Employment. Neither the Plan nor any Option or Stock Purchase Right shall confer upon any Optionee any right with respect
to continuing the Optionee’s relationship as a Service Provider with the Company, nor shall it interfere in any way with his or her or its right or the Company’s right to terminate such relationship at any time, with or without cause, and
with or without notice. 
 7. TERM OF PLAN. Subject to stockholder approval in
accordance with Section 19, the Plan shall become effective upon its adoption by the Board. Unless sooner terminated under Section 15, it shall continue in effect for a term of ten (10) years from the later of (i) the effective
date of the Plan, or (ii) the earlier of the most recent board or stockholder approval of an increase in the number of Shares reserved for issuance under the Plan. 

8. TERM OF OPTION. The term of each Option shall be stated in the Option Agreement;
provided, however, that the term shall be no more than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to an Optionee who, at the time the Option is granted, owns stock representing more than ten
percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Option shall be five (5) years from the date of grant or such shorter term as may be provided in the Option Agreement.


  
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 9. OPTION EXERCISE PRICE AND
CONSIDERATION. 
 (a) Exercise Price. The per share exercise price for the Shares to be issued upon exercise of an
Option shall be such price as is determined by the Administrator, but shall be subject to the following: 
 (i) In the case
of an Incentive Stock Option, 
 (1) granted to an Employee who, at the time of grant of such Option, owns stock representing more
than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than 110% of the Fair Market Value per Share on the date of grant. 

(2) granted to any other Employee, the per Share exercise price shall be no less than 100% of the Fair Market Value per Share on the
date of grant. 
 (ii) In the case of a Nonstatutory Stock Option, 

(1) granted to a Service Provider who, at the time of grant of such Option, owns stock representing more than ten percent
(10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than 110% of the Fair Market Value per Share on the date of grant. 

(2) granted to any other Service Provider, the per Share exercise price shall be no less than 85% of the Fair Market Value per Share
on the date of grant. 
 (iii) Notwithstanding the foregoing, Options may be granted with a per Share exercise price other
than as required above pursuant to a merger or other corporate transaction. 
 (b) Forms of Consideration. The consideration
to be paid for the Shares to be issued upon exercise of an Option, including the method of payment, shall be determined by the Administrator (and, in the case of an Incentive Stock Option, shall be determined at the time of grant). Such
consideration may consist of, without limitation, (1) cash, (2) check, (3) promissory note, (4) other Shares, provided Shares acquired directly from the Company (x) have been owned by the Optionee for more than six months on
the date of surrender, and (y) have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which such Option shall be exercised, (5) consideration received by the Company under a cashless
exercise program implemented by the Company in connection with the Plan, or (6) any combination of the foregoing methods of payment. In making its determination as to the type of consideration to accept, the Administrator shall consider if
acceptance of such consideration may be reasonably expected to benefit the Company. 

  
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 10. EXERCISE OF OPTION. 

(a) Procedure for Exercise; Rights as a Stockholder. 

(i) Any Option granted hereunder shall be exercisable according to the terms hereof at such times and under such conditions as
determined by the Administrator and set forth in the Option Agreement. An Option may not be exercised for a fraction of a Share. Except in the case of Options granted to officers, Directors and Consultants, Options shall become exercisable at a rate
of no less than 20% per year over five (5) years from the date the Options are granted. 
 (ii) An Option shall be
deemed exercised when the Company receives (i) written or electronic notice of exercise (in accordance with the Option Agreement) from the person entitled to exercise the Option, and (ii) full payment for the Shares with respect to which
the Option is exercised. Full payment may consist of any consideration and method of payment authorized by the Administrator and permitted by the Option Agreement and the Plan. Shares issued upon exercise of an Option shall be issued in the name of
the Optionee or, if requested by the Optionee, in the name of the Optionee and his or her spouse. Until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company),
no right to vote or receive dividends or any other rights as a stockholder shall exist with respect to the Shares, notwithstanding the exercise of the Option. The Company shall issue (or cause to be issued) such Shares promptly after the Option is
exercised. No adjustment will be made for a dividend or other right for which the record date is prior to the date the Shares are issued, except as provided in Section 13 of the Plan. 

(iii) Exercise of an Option in any manner shall result in a decrease in the number of Shares thereafter available, both for purposes
of the Plan and for sale under the Option, by the number of Shares as to which the Option is exercised. 
 (b) Termination of
Relationship as a Service Provider. If an Optionee ceases to be a Service Provider, such Optionee may exercise his or her or its Option within thirty (30) days of termination, or such longer period of time as specified in the Option
Agreement, to the extent that the Option is vested on the date of termination (but in no event later than the expiration of the term of the Option as set forth in the Option Agreement). If, on the date of termination, the Optionee is not vested as
to his or her or its entire Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified by the Administrator, the Option
shall terminate, and the Shares covered by such Option shall revert to the Plan. 
 (c) Disability of Optionee. If an Optionee
ceases to be a Service Provider as a result of the Optionee’s Disability, the Optionee may exercise his or her Option within six (6) months of termination, or such longer period of time as specified in the Option Agreement, to the extent
the Option is vested on the date of termination (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement). If, on the date of termination, the Optionee is not vested as to his or her or its entire
Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified herein, the Option shall terminate, and the Shares covered
by such Option shall revert to the Plan. 

  
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 (d) Death of Optionee. If an Optionee dies while a Service Provider, the Option may be
exercised within six (6) months following Optionee’s death, or such longer period of time as specified in the Option Agreement, to the extent that the Option is vested on the date of death (but in no event later than the expiration of the
term of such Option as set forth in the Option Agreement) by the Optionee’s designated beneficiary, provided such beneficiary has been designated prior to Optionee’s death in a form acceptable to the Administrator. If no such beneficiary
has been designated by the Optionee, then such Option may be exercised by the personal representative of the Optionee’s estate or by the person(s) to whom the Option is transferred pursuant to the Optionee’s will or in accordance with the
laws of descent and distribution. If, at the time of death, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall immediately revert to the Plan. If the Option is not so exercised
within the time specified herein, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 

(e) Leaves of Absence. 

(i) Unless the Administrator provides otherwise, vesting of Options granted hereunder to officers and Directors shall be suspended
during any unpaid leave of absence. 
 (ii) A Service Provider shall not cease to be an Employee in the case of (A) any
leave of absence approved by the Company or (B) transfers between locations of the Company or between the Company, its Parent, any Subsidiary, or any successor. 

(iii) For purposes of Incentive Stock Options, no such leave may exceed ninety (90) days, unless reemployment upon expiration of
such leave is guaranteed by statute or contract. If reemployment upon expiration of a leave of absence approved by the Company is not so guaranteed, then three (3) months following the 91st
day of such leave, any Incentive Stock Option held by the Optionee shall cease to be treated as an Incentive Stock Option and shall be treated for tax purposes as a Nonstatutory Stock Option. 

11. STOCK PURCHASE RIGHTS. 

(a) Rights to Purchase. Stock Purchase Rights may be issued either alone, in addition to, or in tandem with other awards granted under
the Plan and/or cash awards made outside of the Plan. After the Administrator determines that it will offer Stock Purchase Rights under the Plan, it shall advise the offeree in writing or electronically of the terms, conditions and restrictions
related to the offer, including the number of Shares that such person shall be entitled to purchase, the price to be paid, and the time within which such person must accept such offer. The offer shall be accepted by execution of a Restricted Stock
Purchase Agreement in the form determined by the Administrator. 
 (b) Repurchase Option. Unless the Administrator determines
otherwise, the Restricted Stock Purchase Agreement shall grant the Company a repurchase option exercisable within 90 days of the voluntary or involuntary termination of the purchaser’s service with the


  
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Company for any reason (including death or disability). The purchase price for Shares repurchased pursuant to the Restricted Stock Purchase Agreement shall be the original price paid by the
purchaser and may be paid by cancellation of any indebtedness of the purchaser to the Company. The repurchase option shall lapse at such rate as the Administrator may determine. 

(c) Other Provisions. The Restricted Stock Purchase Agreement shall contain such other terms, provisions and conditions not
inconsistent with the Plan as may be determined by the Administrator in its sole discretion. 
 (d) Rights as a Stockholder.
Once the Stock Purchase Right is exercised, the purchaser shall have rights equivalent to those of a stockholder and shall be a stockholder when his or her or its purchase is entered upon the records of the duly authorized transfer agent of the
Company. No adjustment shall be made for a dividend or other right for which the record date is prior to the date the Stock Purchase Right is exercised, except as provided in Section 13 of the Plan. 

12. LIMITED TRANSFERABILITY OF OPTIONS AND STOCK
PURCHASE RIGHTS. Unless determined otherwise by the Administrator, Options and Stock Purchase Rights may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by will or
the laws of descent and distribution, and may be exercised during the lifetime of the Optionee, only by the Optionee. If the Administrator in its sole discretion makes an Option or Stock Purchase Right transferable, such Option or Stock Purchase
Right may only be transferred (i) by will, (ii) by the laws of descent and distribution, or (iii) to family members (within the meaning of Rule 701 of the Securities Act) through gifts or domestic relations orders, as permitted by
Rule 701 of the Securities Act. 
 13. ADJUSTMENTS; DISSOLUTION OR
LIQUIDATION; MERGER OR CHANGE IN CONTROL. 

(a) Adjustments. In the event that any dividend or other distribution (whether in the form of cash, Shares, other securities, or other
property), recapitalization, stock split, reverse stock split, reorganization, merger, consolidation, split-up, spin-off, combination, repurchase, or exchange of Shares or other securities of the Company, or other change in the corporate structure
of the Company affecting the Shares occurs, the Administrator, in order to prevent diminution or enlargement of the benefits or potential benefits intended to be made available under the Plan, may (in its sole discretion) adjust the number and class
of Shares that may be delivered under the Plan and/or the number, class, and price of Shares covered by each outstanding Option or Stock Purchase Right. 

(b) Dissolution or Liquidation. In the event of the proposed dissolution or liquidation of the Company, the Administrator shall notify
each Optionee as soon as practicable prior to the effective date of such proposed transaction. To the extent it has not been previously exercised, an Option or Stock Purchase Right will terminate immediately prior to the consummation of such
proposed action. 
 (c) Merger or Change in Control. In the event of a merger of the Company with or into another corporation,
or a Change in Control, each outstanding Option and Stock 

  
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Purchase Right shall be assumed or an equivalent option substituted by the successor corporation or a Parent or Subsidiary of the successor corporation. In the event that the successor
corporation in a merger or Change in Control refuses to assume or substitute for the Option or Stock Purchase Right, then the Optionee shall fully vest in and have the right to exercise the Option or Stock Purchase Right as to all of the Optioned
Stock, including Shares as to which it would not otherwise be vested or exercisable. If an Option or Stock Purchase Right becomes fully vested and exercisable in lieu of assumption or substitution in the event of a merger or Change in Control, the
Administrator shall notify the Optionee in writing or electronically that this Option or Stock Purchase Right shall be fully exercisable for a period of fifteen (15) days from the date of such notice, and the Option or Stock Purchase Right
shall terminate upon expiration of such period. For the purposes of this paragraph, the Option or Stock Purchase Right shall be considered assumed if, following the merger or Change in Control, the option or right confers the right to purchase or
receive, for each Share of Optioned Stock subject to the Option or Stock Purchase Right immediately prior to the merger or Change in Control, the consideration (whether stock, cash, or other securities or property) received in the merger or Change
in Control by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were offered a choice of consideration, the type of consideration chosen by the holders of a majority of the outstanding Shares);
provided, however, that if such consideration received in the merger or Change in Control is not solely common stock of the successor corporation or its Parent, the Administrator may, with the consent of the successor corporation, provide for the
consideration to be received upon the exercise of the Option or Stock Purchase Right, for each Share of Optioned Stock subject to the Option or Stock Purchase Right, to be solely common stock of the successor corporation or its Parent equal in fair
market value to the per share consideration received by holders of common stock in the merger or Change in Control. 
 14.
TIME OF GRANTING OPTIONS AND STOCK PURCHASE RIGHTS. The date of grant of an Option or Stock Purchase Right shall, for all
purposes, be the date on which the Administrator makes the determination granting such Option or Stock Purchase Right, or such later date as is determined by the Administrator. Notice of the determination shall be given to each Service Provider to
whom an Option or Stock Purchase Right is so granted within a reasonable time after the date of such grant. 
 15.
AMENDMENT AND TERMINATION OF THE PLAN. 

(a) Amendment and Termination. The Board may at any time amend, alter, suspend or terminate the Plan. 

(b) Stockholder Approval. The Board shall obtain stockholder approval of any Plan amendment to the extent necessary and desirable to
comply with Applicable Laws. 
 (c) Effect of Amendment or Termination. No amendment, alteration, suspension or termination of
the Plan shall impair the rights of any Optionee, unless mutually agreed otherwise between the Optionee and the Administrator, which agreement must be in writing and signed by the Optionee and the Company. Termination of the Plan shall not affect
the Administrator’s ability to exercise the powers granted to it hereunder with respect to Options granted under the Plan prior to the date of such termination. 

  
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 (d) Section 409A of the Code. To the extent that the Board determines that any Option
or Stock Purchase Right granted under the Plan is subject to Section 409A of the Code, the corresponding Option Agreement or Restricted Stock Purchase Agreement evidencing such Option or Stock Purchase Right shall incorporate the terms and
conditions necessary to avoid the consequences described in Section 409A(a)(1) of the Code. To the extent applicable, the Plan and all Option Agreements and Restricted Stock Purchase Agreements shall be interpreted in accordance with
Section 409A of the Code and Department of Treasury regulations and other interpretive guidance issued thereunder, including without limitation any such regulations or other guidance that may be issued or amended after the effective date of the
Plan. Notwithstanding any provision of the Plan to the contrary, in the event that following the effective date of the Plan the Board determines that any Option or Stock Purchase Right may be subject to Section 409A of the Code and related
Department of Treasury guidance (including such Department of Treasury guidance as may be issued after the effective date of this Plan), the Board may adopt such amendments to the Plan and the applicable Option Agreements or Restricted Stock
Purchase Agreements or adopt other policies and procedures (including amendments, policies and procedures with retroactive effect), or take any other actions, that the Board determines are necessary or appropriate to (1) exempt such Options and
Stock Purchase Rights from Section 409A of the Code and/or preserve the intended tax treatment of the benefits provided with respect to each such Option and Stock Purchase Right, or (2) comply with the requirements of Section 409A of
the Code and related Department of Treasury guidance. 
 16. CONDITIONS UPON ISSUANCE
OF SHARES. 
 (a) Legal Compliance. Shares shall not be issued pursuant to the exercise of an
Option unless the exercise of such Option and the issuance and delivery of such Shares shall comply with Applicable Laws and shall be further subject to the approval of counsel for the Company with respect to such compliance. 

(b) Investment Representations. As a condition to the exercise of an Option, the Administrator may require the person exercising such
Option to represent and warrant at the time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares if, in the opinion of counsel for the Company, such a
representation is required. 
 17. INABILITY TO OBTAIN AUTHORITY.
The inability of the Company to obtain authority from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder, shall relieve the Company
of any liability in respect of the failure to issue or sell such Shares as to which such requisite authority shall not have been obtained. 

18. RESERVATION OF SHARES. The Company, during the term of the Plan, shall at all times
reserve and keep available such number of Shares as shall be sufficient to satisfy the requirements of the Plan. 
 19.
STOCKHOLDER APPROVAL. The Plan shall be subject to approval by the stockholders of the Company within twelve (12) months after the date the Plan is adopted. Such stockholder approval shall be obtained in the
degree and manner required under Applicable Laws. 

  
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 20. INFORMATION TO OPTIONEES. The Company
shall provide to each Optionee and to each individual who acquires Shares pursuant to the Plan, not less frequently than annually during the period such Optionee has one or more Options or Stock Purchase Rights outstanding, and, in the case of an
individual who acquires Shares pursuant to the Plan, during the period such individual owns such Shares, copies of annual financial statements. The Company shall not be required to provide such statements to key employees whose duties in connection
with the Company assure their access to equivalent information. 

  
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 PRONAI THERAPEUTICS, INC. 

FIRST AMENDMENT TO 2008 STOCK PLAN 

THIS FIRST AMENDMENT TO 2008 STOCK
PLAN (this “Amendment”) is made effective as of the 23rd day of June, 2011 (the “Effective
Date”). 
 BACKGROUND 

WHEREAS, the Board of Directors (the “Board”) and stockholders (the “Stockholders”) of
PRONAI THERAPEUTICS, INC., a Delaware corporation (the “Company”) have previously approved and adopted the 2008 Stock Plan (the “Plan”); and

 WHEREAS, the Board and the Stockholders have approved an amendment to the Plan, as provided herein. 

NOW, THEREFORE, the Plan is hereby amended as follows: 

TERMS AND CONDITIONS 

1. AMENDMENT TO SECTION 3(a). As of the Effective Date, Section 3(a) of the Plan
is hereby deleted in its entirety and replaced with the following: 
 “(a) Subject to the provisions of
Section 13 of the Plan, the maximum aggregate number of Shares that may be subject to option and sold under the Plan is 4,300,000 Shares. In no event shall the number of Shares issued pursuant to Incentive Stock Options exceed 4,300,000 Shares.
The Shares may be authorized but unissued, or reacquired Common Stock.” 
 2. CONSTRUCTION. Unless otherwise
defined herein, capitalized terms shall have the meanings set forth in the Plan. The terms of this Amendment amend and modify the Plan as if fully set forth therein. If there is any conflict between the terms, conditions and obligations of this
Amendment and the Plan, this Amendment’s terms, conditions and obligations shall control. All other provisions of the Plan not specifically modified by this Amendment are preserved. 

3. FACSIMILE SIGNATURE. This Amendment may be executed by facsimile signature. 

SIGNATURES ON THE FOLLOWING PAGE 

  
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 IN WITNESS WHEREOF, this First Amendment to 2008 Stock Plan is made effective as of the date
first set forth above. 
  

			
	THE COMPANY:
	
	PRONAI THERAPEUTICS, INC.
		
	By:		 /s/ Charles Bisgaier

	Name:		Charles Bisgaier
	Title:		President and Interim CEO
			

 SIGNATURE PAGE TO FIRST AMENDMENT
TO 2008 STOCK PLAN 







 PRONAI THERAPEUTICS, INC. 

SECOND AMENDMENT TO 2008 STOCK PLAN 

THIS FIRST AMENDMENT TO 2008 STOCK
PLAN (this “Amendment”) is made effective as of the 29th day of March, 2013 (the “Effective
Date”). 
 BACKGROUND 

WHEREAS, the Board of Directors (the “Board”) and stockholders (the “Stockholders”) of
PRONAI THERAPEUTICS, INC., a Delaware corporation (the “Company”) have previously approved and adopted the 2008 Stock Plan (the “Plan”); and

 WHEREAS, the Board has approved an amendment to the Plan, as provided herein. 

NOW, THEREFORE, the Plan is hereby amended as follows: 

TERMS AND CONDITIONS 

1. AMENDMENT TO SECTION 3(a). As of the Effective Date, Section 3(a) of the Plan
is hereby deleted in its entirety and replaced with the following: 
 “(a) Subject to the provisions of
Section 13 of the Plan, the maximum aggregate number of Shares that may be subject to option and sold under the Plan is 7,900,000 Shares. In no event shall the number of Shares issued pursuant to Incentive Stock Options exceed 7,900,000 Shares.
The Shares may be authorized but unissued, or reacquired Common Stock.” 
 2. CONSTRUCTION. Unless otherwise
defined herein, capitalized terms shall have the meanings set forth in the Plan. The terms of this Amendment amend and modify the Plan as if fully set forth therein. If there is any conflict between the terms, conditions and obligations of this
Amendment and the Plan, this Amendment’s terms, conditions and obligations shall control. All other provisions of the Plan not specifically modified by this Amendment are preserved. 

3. FACSIMILE SIGNATURE. This Amendment may be executed by facsimile signature. 

SIGNATURES ON THE FOLLOWING PAGE 

  
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 IN WITNESS WHEREOF, this Second Amendment to 2008 Stock Plan is made effective as of the date
first set forth above. 
  

			
	THE COMPANY:
	
	PRONAI THERAPEUTICS, INC.
		
	By:		 /s/ Mina Sooch

	Name:		Mina Sooch
	Title:		President and CEO

 SIGNATURE PAGE TO FIRST AMENDMENT
TO 2008 STOCK PLAN 







 PRONAI THERAPEUTICS, INC. 

THIRD AMENDMENT TO 2008 STOCK PLAN 

THIS THIRD AMENDMENT TO 2008 STOCK
PLAN (this “Amendment”) is made effective as of the 12th day of December 2013 (the “Effective
Date”). 
 BACKGROUND 

WHEREAS, the Board of Directors (the “Board”) and stockholders (the “Stockholders”) of
PRONAI THERAPEUTICS, INC., a Delaware corporation (the “Company”) have previously approved and adopted the 2008 Stock Plan (the “Plan”); and

 WHEREAS, the Board has approved an amendment to the Plan, as provided herein. 

NOW, THEREFORE, the Plan is hereby amended as follows: 

TERMS AND CONDITIONS 

1. AMENDMENT TO SECTION 3(a). As of the Effective Date, Section 3(a) of the Plan
is hereby deleted in its entirety and replaced with the following: 
 “(a) Subject to the provisions of
Section 13 of the Plan, the maximum aggregate number of Shares that may be subject to option and sold under the Plan is 11,775,000 Shares. In no event shall the number of Shares issued pursuant to Incentive Stock Options exceed 11,775,000
Shares. The Shares may be authorized but unissued, or reacquired Common Stock.” 
 2. CONSTRUCTION. Unless
otherwise defined herein, capitalized terms shall have the meanings set forth in the Plan. The terms of this Amendment amend and modify the Plan as if fully set forth therein. If there is any conflict between the terms, conditions and obligations of
this Amendment and the Plan, this Amendment’s terms, conditions and obligations shall control. All other provisions of the Plan not specifically modified by this Amendment are preserved. 

3. FACSIMILE SIGNATURE. This Amendment may be executed by facsimile signature. 

SIGNATURES ON THE FOLLOWING PAGE 

  
 1 








 IN WITNESS WHEREOF, this Third Amendment to 2008 Stock Plan is made effective as of the date
first set forth above. 
  

			
	THE COMPANY:
	
	PRONAI THERAPEUTICS, INC.
		
	By:		 /s/ Mina Sooch

	Name:		Mina Sooch
	Title:		President and CEO

 SIGNATURE PAGE TO THIRD AMENDMENT
TO 2008 STOCK PLAN 







 PRONAI THERAPEUTICS, INC. 

FOURTH AMENDMENT TO 2008 STOCK PLAN 

THIS FOURTH AMENDMENT TO 2008 STOCK
PLAN (this “Amendment”) is made effective as of the 10th day of April, 2014 (the “Effective
Date”). 
 BACKGROUND 

WHEREAS, the Board of Directors (the “Board”) and stockholders (the “Stockholders”) of
PRONAI THERAPEUTICS, INC., a Delaware corporation (the “Company”) have previously approved and adopted the 2008 Stock Plan (the “Plan”); and

 WHEREAS, the Board has approved an amendment to the Plan, as provided herein. 

NOW, THEREFORE, the Plan is hereby amended as follows: 

TERMS AND CONDITIONS 

1. AMENDMENT TO SECTION 3(a). As of the Effective Date, Section 3(a) of the Plan
is hereby deleted in its entirety and replaced with the following: 
 “(a) Subject to the provisions of
Section 13 of the Plan, the maximum aggregate number of Shares that may be subject to option and sold under the Plan is 20,775,000 Shares. In no event shall the number of Shares issued pursuant to Incentive Stock Options exceed 20,775,000
Shares. The Shares may be authorized but unissued, or reacquired Common Stock.” 
 2. CONSTRUCTION. Unless
otherwise defined herein, capitalized terms shall have the meanings set forth in the Plan. The terms of this Amendment amend and modify the Plan as if fully set forth therein. If there is any conflict between the terms, conditions and obligations of
this Amendment and the Plan, this Amendment’s terms, conditions and obligations shall control. All other provisions of the Plan not specifically modified by this Amendment are preserved. 

3. FACSIMILE SIGNATURE. This Amendment may be executed by facsimile signature. 

SIGNATURES ON THE FOLLOWING PAGE 

  
 1 








 IN WITNESS WHEREOF, this Fourth Amendment to 2008 Stock Plan is made effective as of the date
first set forth above. 
  

			
	THE COMPANY:
	
	PRONAI THERAPEUTICS, INC.
		
	By:		 /s/ Mina Sooch

	Name:		Mina Sooch
	Title:		President and CEO

 SIGNATURE PAGE TO FOURTH AMENDMENT
TO 2008 STOCK PLAN 







 PRONAI THERAPEUTICS, INC. 

FIFTH AMENDMENT TO 2008 STOCK PLAN 

THIS FIFTH AMENDMENT TO 2008 STOCK
PLAN (this “Amendment”) is made effective as of the 10th day of September, 2014 (the “Effective
Date”). 
 BACKGROUND 

WHEREAS, the Board of Directors (the “Board”) and stockholders (the “Stockholders”) of
PRONAI THERAPEUTICS, INC., a Delaware corporation (the “Company”) have previously approved and adopted the 2008 Stock Plan (the “Plan”); and

 WHEREAS, the Board and the Stockholders have approved an amendment to the Plan, as provided herein. 

NOW, THEREFORE, the Plan is hereby amended as follows: 

TERMS AND CONDITIONS 

1. AMENDMENT TO SECTION 3(a). As of the Effective Date, Section 3(a) of the Plan
is hereby deleted in its entirety and replaced with the following: 
 “(a) Subject to the provisions of
Section 13 of the Plan, the maximum aggregate number of Shares that may be subject to option and sold under the Plan is 35,775,000 Shares. In no event shall the number of Shares issued pursuant to Incentive Stock Options exceed 35,775,000
Shares. The Shares may be authorized but unissued, or reacquired Common Stock.” 
 2. CONSTRUCTION. Unless
otherwise defined herein, capitalized terms shall have the meanings set forth in the Plan. The terms of this Amendment amend and modify the Plan as if fully set forth therein. If there is any conflict between the terms, conditions and obligations of
this Amendment and the Plan, this Amendment’s terms, conditions and obligations shall control. All other provisions of the Plan not specifically modified by this Amendment are preserved. 

3. FACSIMILE SIGNATURE. This Amendment may be executed by facsimile signature. 

SIGNATURES ON THE FOLLOWING PAGE 

  
 1 








 IN WITNESS WHEREOF, this Fifth Amendment to 2008 Stock Plan is made effective as of the date
first set forth above. 
  

			
	THE COMPANY:
	
	PRONAI THERAPEUTICS, INC.
		
	By:		 /s/ Nick Glover

	Name:		Nick Glover, Ph.D.
	Title:		President and Chief Executive Officer

 SIGNATURE PAGE TO FIFTH AMENDMENT
TO 2008 STOCK PLAN 







 PRONAI THERAPEUTICS, INC. 

2008 STOCK PLAN 
 STOCK
OPTION AGREEMENT 
 Unless otherwise defined herein, the terms defined in the 2008 Stock Plan shall have the same defined
meanings in this Stock Option Agreement (this “Option Agreement”). 
  

	I.	NOTICE OF STOCK OPTION GRANT 

 «Name» 

The undersigned Optionee has been granted an Option to purchase Common Stock of the Company, subject to the terms and conditions of the Plan
and this Option Agreement, as follows: 
  

			
	Optionholder:		  

	Date of Grant:		  

	Vesting Commencement Date:		  

	Number of Shares Subject to Option:		  

	Exercise Price (Per Share):		  

	Total Exercise Price:		  

	Expiration Date:		  


  

					
	Type of Grant:		  ̈       Incentive Stock Option1
		  ̈       Nonstatutory Stock Option

			
	Exercise Schedule:		Same as Vesting Schedule		
		
	Vesting Schedule:		 [1/4 of the shares vest 1 year after the Vesting Commencement Date.

1/48 of the shares vest monthly thereafter over the next three years.]

		
	Payment:		 By one or a combination of the following methods of payment (described in the Stock Option Agreement):

 

 ̈       Cash or check

 

 ̈       Bank draft or money order
payable to the Company
  
  ̈       Pursuant to a Regulation T Program (cashless exercise) if the shares are publicly traded
  

 ̈       Delivery of already-owned
shares if shares are publicly traded
  
  ̈       Net exercise

		
	Termination Period:		This Option shall be exercisable for three months after Optionee ceases to be a Service Provider. Upon Optionee’s death or Disability, this Option may be exercised for one (1) year after Optionee ceases to be a
Service Provider. In no event may Optionee exercise this Option after the Term/Expiration Date as provided above.

  

	1 	If this is an Incentive Stock Option, it (plus other outstanding Incentive Stock Options) cannot be first exercisable for more than $100,000 in value (measured by exercise price) in any calendar year. Any
excess over $100,000 is a Nonstatutory Stock Option. 


  
 1 









	II.	AGREEMENT 

 1. GRANT OF OPTION. 

(a) The Plan Administrator of the Company hereby grants to the Optionee named in the Notice of Grant in
part I of this Option Agreement (“Optionee”), an option (this “Option”) to purchase the number of Shares set forth in the Notice of Grant, at the exercise price per Share set forth in the Notice of
Grant (the “Exercise Price”), and subject to the terms and conditions of the Plan, which is incorporated herein by reference. Subject to Section 15(c) of the Plan, in the event of a conflict between the terms and
conditions of the Plan and this Option Agreement, the terms and conditions of the Plan shall prevail. 
 (b) If
designated in the Notice of Grant as an Incentive Stock Option (“ISO”), this Option is intended to qualify as an Incentive Stock Option as defined in Section 422 of the Code. Nevertheless, to the extent
that it exceeds the $100,000 rule of Code Section 422(d), this Option shall be treated as a Nonstatutory Stock Option (“NSO”). 

2. EXERCISE OF OPTION. 

(a) Right to Exercise. This Option shall be exercisable during its term in accordance with the Vesting Schedule set out in the Notice
of Grant and with the applicable provisions of the Plan and this Option Agreement. 
 (b) Method of Exercise. 

(i) This Option shall be exercisable by delivery of an exercise notice in the form attached as
EXHIBIT A (the “Exercise Notice”) which shall state the election to exercise this Option, the number of Shares with respect to which this Option is being exercised, and
such other representations and agreements as may be required by the Company. The Exercise Notice shall be accompanied by payment of the aggregate Exercise Price as to all Exercised Shares. This Option shall be deemed to be exercised upon receipt by
the Company of such fully executed Exercise Notice accompanied by the aggregate Exercise Price. 
 (ii) No Shares
shall be issued pursuant to the exercise of this Option unless such issuance and such exercise complies with Applicable Laws. Assuming such compliance, for income tax purposes the Shares shall be considered transferred to Optionee on the date on
which this Option is exercised with respect to such Shares. 
 3. OPTIONEE’S
REPRESENTATIONS. In the event the Shares have not been registered under the Securities Act of 1933, as amended, at the time this Option is exercised, Optionee shall, if required by the Company, concurrently with the exercise of
all or any portion of this Option, deliver to the Company his or her or its Investment Representation Statement in the form attached hereto as EXHIBIT B. 

4. LOCK-UP PERIOD. 

(a) Optionee hereby agrees that Optionee shall not offer, pledge, sell, contract to sell, sell any option or contract to purchase,
purchase any option or contract to sell, grant any  

  
 2 








 
option, right or warrant to purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any Common Stock (or other securities) of the Company or enter into any swap, hedging or
other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of any Common Stock (or other securities) of the Company held by Optionee (other than those included in the registration) for a period
specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed one hundred eighty (180) days following the effective date of any registration statement of the Company filed under the
Securities Act. 
 (b) Optionee agrees to execute and deliver such other agreements as may be reasonably requested by the Company or
the underwriter which are consistent with the foregoing or which are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company,
Optionee shall provide, within ten (10) days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a
registration statement filed under the Securities Act. The obligations described in this Section shall not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms that may be promulgated in the
future, or a registration relating solely to a Commission Rule 145 transaction on Form S-4 or similar forms that may be promulgated in the future. The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other
securities) subject to the foregoing restriction until the end of said one hundred eighty (180) day period. Optionee agrees that any transferee of this Option or shares acquired pursuant to this Option shall be bound by this Section.

 5. METHOD OF PAYMENT. Payment of the aggregate Exercise Price shall be by any of
the following, or a combination thereof, at the election of Optionee: 
 (a) cash or check; 

(b) consideration received by the Company under a formal cashless exercise program adopted by the Company in connection with the Plan;
or 
 (c) surrender of other Shares which, (i) in the case of Shares acquired from the Company, either directly or
indirectly, have been owned by the Optionee for more than six (6) months on the date of surrender, and (ii) have a Fair Market Value on the date of surrender equal to the aggregate Exercise Price of the Exercised Shares. 

6. RESTRICTIONS ON EXERCISE. This Option may not be exercised until such time as the Plan
has been approved by the stockholders of the Company, or if the issuance of such Shares upon such exercise or the method of payment of consideration for such shares would constitute a violation of any Applicable Law. 

7. NON-TRANSFERABILITY OF OPTION. This Option may not be transferred in any
manner otherwise than by will or by the laws of descent or distribution and may be exercised during the lifetime of Optionee only by Optionee. The terms of the Plan and this Option Agreement shall be binding upon the executors, administrators,
heirs, successors and assigns of the Optionee. 

  
 3 








 8. TERM OF OPTION. This Option may be
exercised only within the term set out in the Notice of Grant, and may be exercised during such term only in accordance with the Plan and the terms of this Option. 

9. TAX OBLIGATIONS. 

(a) Withholding Taxes. Optionee agrees to make appropriate arrangements with the Company (or the Parent or Subsidiary employing or
retaining Optionee) for the satisfaction of all Federal, state, local and foreign income and employment tax withholding requirements applicable to the Option exercise. Optionee acknowledges and agrees that the Company may refuse to honor the
exercise and refuse to deliver Shares if such withholding amounts are not delivered at the time of exercise. 
 (b) Notice of
Disqualifying Disposition of ISO Shares. If the Option granted to Optionee herein is an ISO, and if Optionee sells or otherwise disposes of any of the Shares acquired pursuant to the ISO on or before the later of (1) the date two years
after the Date of Grant, or (2) the date one year after the date of exercise, Optionee shall immediately notify the Company in writing of such disposition. Optionee agrees that Optionee may be subject to income tax withholding by the Company on
the compensation income recognized by Optionee. 
 10. ENTIRE AGREEMENT; GOVERNING
LAW. The Plan is incorporated herein by reference. The Plan and this Option Agreement constitute the entire agreement of the parties with respect to the subject matter hereof and supersede in their entirety all prior undertakings
and agreements of the Company and Optionee with respect to the subject matter hereof, and may not be modified adversely to the Optionee’s interest except by means of a writing signed by the Company and Optionee. This Option is governed by the
internal substantive laws but not the choice of law rules of Michigan. 
 11. NO GUARANTEE
OF CONTINUED SERVICE. OPTIONEE ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES PURSUANT TO THE VESTING SCHEDULE HEREOF IS EARNED ONLY BY CONTINUING AS A SERVICE PROVIDER AT THE WILL OF THE COMPANY
(NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED THIS OPTION OR ACQUIRING SHARES HEREUNDER). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT THIS OPTION, THE TRANSACTIONS CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH HEREIN DO NOT
CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF CONTINUED ENGAGEMENT AS A SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD, OR AT ALL, AND SHALL NOT INTERFERE IN ANY WAY WITH OPTIONEE’S RIGHT OR THE COMPANY’S RIGHT TO TERMINATE
OPTIONEE’S RELATIONSHIP AS A SERVICE PROVIDER AT ANY TIME, WITH OR WITHOUT CAUSE. 

  
 4 








 12. ACKNOWLEDGEMENTS. 

(a) Optionee acknowledges receipt of a copy of the Plan and represents that he, she or it is familiar with the terms and provisions
thereof, and hereby accepts this Option subject to all of the terms and provisions thereof. Optionee has reviewed the Plan and this Option in their entirety, has had an opportunity to obtain the advice of counsel prior to executing this Option and
fully understands all provisions of the Option. Optionee hereby agrees to accept as binding, conclusive and final all decisions or interpretations of the Administrator upon any questions arising under the Plan or this Option. Optionee further agrees
to notify the Company upon any change in the residence address indicated below. 
 (b) Notwithstanding the Board of
Directors’ good faith determination of the fair market value of the Common Stock of the Company, the taxing authorities may assert that the fair market value of the Shares on the date of award was greater than the exercise price per share.

 (c) Optionee acknowledges that under Section 409A of the Code, if the exercise price per share of this Option is less
than the fair market value of the Common Stock of the Company on the date of this Option, this Option may be treated as a form of deferred compensation and Optionee may be subject to an additional 20% tax, plus interest and possible penalties.
Optionee is encouraged to consult a tax advisor regarding the potential impact of Section 409A of the Code. 
 (d)
Optionee acknowledges that the Administrator, in the exercise of its sole discretion and without Optionee’s consent, may amend or modify this Option in any manner and delay the payment of any amounts payable pursuant to this Option to the
minimum extent necessary to meet the requirements of Section 409A of the Code as amplified by any Internal Revenue Service or U.S. Treasury Department regulations or guidance as the Company deems appropriate or advisable. 

 

									
	OPTIONEE:						THE COMPANY:
				
							PRONAI THERAPEUTICS, INC.
				
	  
				By:		  

							Name:		
	Date:		  
				Title:		
					
	Resident Address:		  
				Date:		  

				
	  
						


  
 5 








 EXHIBIT A 

2008 STOCK PLAN 

EXERCISE NOTICE 

PRONAI THERAPEUTICS, INC. 

	
	  

	  


 Attention: Secretary 

1. EXERCISE OF OPTION. Effective as of today,
[            ], the undersigned (“Optionee”) hereby elects to exercise Optionee’s option to purchase
[            ] shares of the Common Stock (the “Shares”) of PRONAI THERAPEUTICS, INC., a Delaware
corporation (the “Company”) under and pursuant to the 2008 Stock Plan (the “Plan”) and the Stock Option Agreement dated             (the
“Option Agreement”). 
 2. DELIVERY OF PAYMENT. Purchaser
herewith delivers to the Company the full purchase price of the Shares, as set forth in the Option Agreement, and any and all withholding taxes due in connection with the exercise of the Option. 

3. REPRESENTATIONS OF OPTIONEE. Optionee acknowledges that Optionee has received, read and
understood the Plan and the Option Agreement and agrees to abide by and be bound by their terms and conditions. 
 4.
RIGHTS AS STOCKHOLDER. Until the issuance of the Shares (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or
receive dividends or any other rights as a stockholder shall exist with respect to the Optioned Stock, notwithstanding the exercise of the Option. The Shares shall be issued to the Optionee as soon as practicable after the Option is exercised in
accordance with the Option Agreement. No adjustment shall be made for a dividend or other right for which the record date is prior to the date of issuance except as provided in Section 13 of the Plan. 

5. COMPANY’S RIGHT OF FIRST REFUSAL.
Before any Shares held by Optionee or any transferee (either being sometimes referred to herein as the “Holder”) may be sold or otherwise transferred (including transfer by gift or operation of law), the Company or its
assignee(s) shall have a right of first refusal to purchase the Shares on the terms and conditions set forth in this Section (the “Right of First Refusal”). 

(a) Notice of Proposed Transfer. The Holder of the Shares shall deliver to the Company a written notice (the
“Notice”) stating: (i) the Holder’s bona fide intention to sell or otherwise transfer such Shares; (ii) the name of each proposed purchaser or other transferee (“Proposed Transferee”);
(iii) the number of Shares to be transferred to each Proposed Transferee; and (iv) the bona fide cash price or other consideration for which the Holder proposes to transfer the Shares (the “Offered Price”), and the
Holder shall offer the Shares at the Offered Price to the Company or its assignee(s). 

  
 1 








 (b) Exercise of Right of First Refusal. At any time within thirty (30) days after
receipt of the Notice, the Company and/or its assignee(s) may, by giving written notice to the Holder, elect to purchase all, but not less than all, of the Shares proposed to be transferred to any one or more of the Proposed Transferees, at the
purchase price determined in accordance with subsection (c) below. 
 (c) Purchase Price. The purchase price (the
“Purchase Price”) for the Shares purchased by the Company or its assignee(s) under this Section shall be the Offered Price. If the Offered Price includes consideration other than cash, the cash equivalent value
of the non-cash consideration shall be determined by the Board of Directors of the Company in good faith. 
 (d) Payment.
Payment of the Purchase Price shall be made, at the option of the Company or its assignee(s), in cash (by check), by cancellation of all or a portion of any outstanding indebtedness of the Holder to the Company (or, in the case of repurchase by an
assignee, to the assignee), or by any combination thereof within thirty (30) days after receipt of the Notice or in the manner and at the times set forth in the Notice. 

(e) Holder’s Right to Transfer. If all of the Shares proposed in the Notice to be transferred to a given Proposed Transferee are
not purchased by the Company and/or its assignee(s) as provided in this Section, then the Holder may sell or otherwise transfer such Shares to that Proposed Transferee at the Offered Price or at a higher price, provided that such sale or other
transfer is consummated within 120 days after the date of the Notice, that any such sale or other transfer is effected in accordance with any applicable securities laws and that the Proposed Transferee agrees in writing that the provisions of this
Section shall continue to apply to the Shares in the hands of such Proposed Transferee. If the Shares described in the Notice are not transferred to the Proposed Transferee within such period, a new Notice shall be given to the Company, and the
Company and/or its assignees shall again be offered the Right of First Refusal before any Shares held by the Holder may be sold or otherwise transferred. 

(f) Exception for Certain Family Transfers. Anything to the contrary contained in this Section notwithstanding, the transfer of any or
all of the Shares during Optionee’s lifetime or on Optionee’s death by will or intestacy to Optionee’s immediate family or a trust for the benefit of Optionee’s immediate family shall be exempt from the provisions of this
Section. “Immediate Family” as used herein shall mean spouse, lineal descendant or antecedent, father, mother, brother or sister. In such case, the transferee or other recipient shall receive and hold the Shares
so transferred subject to the provisions of this Section, and there shall be no further transfer of such Shares except in accordance with the terms of this Section. 

(g) Termination of Right of First Refusal. The Right of First Refusal shall terminate as to any Shares upon the earlier of (i) the
first sale of Common Stock of the Company to the general public, or (ii) a Change in Control in which the successor corporation has equity securities that are publicly traded. 

6. TAX CONSULTATION. Optionee understands that Optionee may suffer adverse tax consequences as a result
of Optionee’s purchase or disposition of the Shares. Optionee represents that Optionee has consulted with any tax consultants Optionee deems advisable in connection with the purchase or disposition of the Shares and that Optionee is not relying
on the Company for any tax advice. 

  
 2 








 7. RESTRICTIVE LEGENDS AND
STOP-TRANSFER ORDERS. 
 (a) Legends. Optionee understands and agrees that the
Company shall cause the legends set forth below or legends substantially equivalent thereto, to be placed upon any certificate(s) evidencing ownership of the Shares together with any other legends that may be required by the Company or by state or
federal securities laws: 
 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE
“ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR, IN THE OPINION OF COMPANY COUNSEL SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER,
SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS IN COMPLIANCE THEREWITH. 
 THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
RESTRICTIONS ON TRANSFER AND A RIGHT OF FIRST REFUSAL HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE EXERCISE NOTICE BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF
THE ISSUER. SUCH TRANSFER RESTRICTIONS AND RIGHT OF FIRST REFUSAL ARE BINDING ON TRANSFEREES OF THESE SHARES. 
 THE SHARES REPRESENTED BY
THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON TRANSFER FOR A PERIOD NOT TO EXCEED 180 DAYS FOLLOWING THE EFFECTIVE DATE OF THE UNDERWRITTEN PUBLIC OFFERING OF THE COMPANY’S SECURITIES AND MAY NOT BE SOLD OR OTHERWISE DISPOSED OF BY THE HOLDER
WITHOUT THE CONSENT OF THE COMPANY OR THE MANAGING UNDERWRITER. 
 (b) Stop-Transfer Notices. Optionee agrees that, in order to
ensure compliance with the restrictions referred to herein, the Company may issue appropriate “stop transfer” instructions to its transfer agent, if any, and that, if the Company transfers its own securities, it may make appropriate
notations to the same effect in its own records. 
 (c) Refusal to Transfer. The Company shall not be required (i) to
transfer on its books any Shares that have been sold or otherwise transferred in violation of any of the provisions of this Exercise Notice or (ii) to treat as owner of such Shares or to accord the right to vote or pay dividends to any
purchaser or other transferee to whom such Shares shall have been so transferred. 

  
 3 








 8. SUCCESSORS AND ASSIGNS. The Company may
assign any of its rights under this Exercise Notice to single or multiple assignees, and this Exercise Notice shall inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer herein set forth, this
Exercise Notice shall be binding upon Optionee and his or her heirs, executors, administrators, successors and assigns. 
 9.
INTERPRETATION. Any dispute regarding the interpretation of this Exercise Notice shall be submitted by Optionee or by the Company forthwith to the Administrator which shall review such dispute at its next regular meeting. The
resolution of such a dispute by the Administrator shall be final and binding on all parties. 
 10. GOVERNING
LAW; SEVERABILITY. This Exercise Notice is governed by the internal substantive laws but not the choice of law rules, of Michigan. In the event that any provision hereof becomes or is declared by a court of
competent jurisdiction to be illegal, unenforceable or void, this Exercise Notice will continue in full force and effect. 
 11.
ENTIRE AGREEMENT. The Plan and Option Agreement are incorporated herein by reference. This Exercise Notice, the Plan, the Option Agreement and the Investment Representation Statement constitute the entire agreement
of the parties with respect to the subject matter hereof and supersede in their entirety all prior undertakings and agreements of the Company and Optionee with respect to the subject matter hereof, and may not be modified adversely to the
Optionee’s interest except by means of a writing signed by the Company and Optionee. 
  

									
	Submitted By:						Accepted By:
				
	OPTIONEE:						THE COMPANY:
				
							PRONAI THERAPEUTICS, INC.
				
	  
				By:		  

							Name:		
	Date:		  
				Title:		
					
	Resident Address:		  
				Date:		  

				
	  
						


  
 4 








 EXHIBIT B 

INVESTMENT REPRESENTATION STATEMENT 
  

			
	OPTIONEE:		«NAME»
		
	COMPANY:		PRONAI THERAPEUTICS, INC.
		
	SECURITY:		COMMON STOCK
		
	AMOUNT:		
		
	DATE:		

 In connection with the purchase of the above-listed Securities, the undersigned Optionee represents to the
Company the following: 
 (a) Optionee is aware of the Company’s business affairs and financial
condition and has acquired sufficient information about the Company to reach an informed and knowledgeable decision to acquire the Securities. Optionee is acquiring these Securities for investment for Optionee’s own account only and not with a
view to, or for resale in connection with, any “distribution” thereof within the meaning of the Securities Act of 1933, as amended (the “Securities Act”). 

(b) Optionee acknowledges and understands that the Securities constitute “restricted securities” under the Securities Act and
have not been registered under the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Optionee’s investment intent as expressed herein. In this connection,
Optionee understands that, in the view of the Securities and Exchange Commission, the statutory basis for such exemption may be unavailable if Optionee’s representation was predicated solely upon a present intention to hold these Securities for
the minimum capital gains period specified under tax statutes, for a deferred sale, for or until an increase or decrease in the market price of the Securities, or for a period of one year or any other fixed period in the future. Optionee further
understands that the Securities must be held indefinitely unless they are subsequently registered under the Securities Act or an exemption from such registration is available. Optionee further acknowledges and understands that the Company is under
no obligation to register the Securities. Optionee understands that the certificate evidencing the Securities will be imprinted with any legend required under applicable state securities laws. 

(c) Optionee is familiar with the provisions of Rule 701 and Rule 144, each promulgated under the Securities Act, which, in substance,
permit limited public resale of “restricted securities” acquired, directly or indirectly from the issuer thereof, in a non-public offering subject to the satisfaction of certain conditions. Rule 701 provides that if the issuer qualifies
under Rule 701 at the time of the grant of the Option to the Optionee, the exercise will be exempt from registration under the Securities Act. In the event the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, ninety (90) days thereafter (or such longer period as any market stand-off agreement may 

  
 5 








 
require) the Securities exempt under Rule 701 may be resold, subject to the satisfaction of certain of the conditions specified by Rule 144, including: (1) the resale being made through a
broker in an unsolicited “broker’s transaction” or in transactions directly with a market maker (as said term is defined under the Securities Exchange Act of 1934); and, in the case of an affiliate, (2) the availability of
certain public information about the Company, (3) the amount of Securities being sold during any three month period not exceeding the limitations specified in Rule 144(e), and (4) the timely filing of a Form 144, if applicable. 

(d) In the event that the Company does not qualify under Rule 701 at the time of grant of the Option, then the Securities may be resold
in certain limited circumstances subject to the provisions of Rule 144, which requires the resale to occur not less than one year after the later of the date the Securities were sold by the Company or the date the Securities were sold by an
affiliate of the Company, within the meaning of Rule 144; and, in the case of acquisition of the Securities by an affiliate, or by a non-affiliate who subsequently holds the Securities less than two years, the satisfaction of the conditions set
forth in sections (1), (2), (3) and (4) of the paragraph immediately above. 
 (e) Optionee further understands that
in the event all of the applicable requirements of Rule 701 or 144 are not satisfied, registration under the Securities Act, compliance with Regulation A, or some other registration exemption will be required; and that, notwithstanding the fact that
Rules 144 and 701 are not exclusive, the Staff of the Securities and Exchange Commission has expressed its opinion that persons proposing to sell private placement securities other than in a registered offering and otherwise than pursuant to Rules
144 or 701 will have a substantial burden of proof in establishing that an exemption from registration is available for such offers or sales, and that such persons and their respective brokers who participate in such transactions do so at their own
risk. Optionee understands that no assurances can be given that any such other registration exemption will be available in such event. 
  

			
	Signature of Optionee
	
	OPTIONEE:
	
	  

		
	Date:		  




  
 6 








 PRONAI THERAPEUTICS, INC. 

2008 STOCK PLAN 
 STOCK
OPTION AGREEMENT—EARLY EXERCISE 
 Unless otherwise defined herein, the terms defined in the 2008 Stock Plan shall have the same
defined meanings in this Stock Option Agreement (this “Option Agreement”). 
  

	I.	NOTICE OF STOCK OPTION GRANT 

 «Name» 

The undersigned Optionee has been granted an Option to purchase Common Stock of the Company, subject to the terms and conditions of the Plan
and this Option Agreement, as follows: 
  

					
	Optionholder:		  
		
	Date of Grant:		  
		
	Vesting Commencement Date:		  
		
	Number of Shares Subject to Option:		  
		
	Exercise Price (Per Share):		  
		
	Total Exercise Price:		  
		
	Expiration Date:		  
		

  

					
	Type of Grant:		 ̈ Incentive Stock Option1		 ̈ Nonstatutory Stock Option
			
	Exercise Schedule:		Same as Vesting Schedule		
		
	Vesting Schedule:		 [1/4 of the shares vest 1 year after the Vesting Commencement Date.

1/48 of the shares vest monthly thereafter over the next three years.]

		
	Payment:		 By one or a combination of the following methods of payment (described in the Stock Option Agreement):

 

 ̈       Cash or check

 

 ̈       Bank draft or money order
payable to the Company
  
  ̈       Pursuant to a Regulation T Program (cashless exercise) if the shares are publicly traded
  

 ̈       Delivery of already-owned
shares if shares are publicly traded
  
  ̈       Net exercise

		
	Termination Period:		This Option shall be exercisable for three months after Optionee ceases to be a Service Provider. Upon Optionee’s death or Disability, this Option may be exercised for one (1) year after Optionee ceases to be a
Service Provider. In no event may Optionee exercise this Option after the Term/Expiration Date as provided above.

  

	1 	If this is an Incentive Stock Option, it (plus other outstanding Incentive Stock Options) cannot be first exercisable for more than $100,000 in value (measured by exercise price) in any calendar year. Any
excess over $100,000 is a Nonstatutory Stock Option. 


  
 1 









	II.	AGREEMENT 

 1. GRANT OF OPTION. 

(a) The Administrator of the Company hereby grants to the Optionee named in the Notice of Grant in Part I of this Option Agreement
(“Optionee”), an option (this “Option”) to purchase the number of Shares set forth in the Notice of Grant, at the exercise price per Share set forth in the Notice of Grant (the “Exercise
Price”), and subject to the terms and conditions of the Plan, which is incorporated herein by reference. Subject to Section 15(c) of the Plan, in the event of a conflict between the terms and conditions of the Plan and this Option
Agreement, the terms and conditions of the Plan shall prevail. 
 (b) If designated in the Notice of Grant as an Incentive Stock
Option (“ISO”), this Option is intended to qualify as an Incentive Stock Option as defined in Section 422 of the Code. Nevertheless, to the extent that it exceeds the $100,000 rule of Code Section 422(d), this
Option shall be treated as a Nonstatutory Stock Option (“NSO”). 
 2. EXERCISE OF
OPTION. This Option shall be exercisable during its term in accordance with the provisions of Section 10 of the Plan as follows: 
  

	 	(a)	Right to Exercise. 

 (i) Subject to subsections 2(a)(ii) and 2(a)(iii) below,
this Option shall be exercisable cumulatively according to the vesting schedule set forth in the Notice of Grant. Alternatively, at the election of the Optionee, this Option may be exercised in whole or in part at any time as to Shares that have not
yet vested. Vested Shares shall not be subject to the Company’s repurchase right (as set forth in the Restricted Stock Purchase Agreement, attached hereto as EXHIBIT C-1). 

(ii) As a condition to exercising this Option for unvested Shares, the Optionee shall execute the Restricted Stock Purchase Agreement.

 (iii) This Option may not be exercised for a fraction of a Share. 

 

	 	(b)	Method of Exercise. 

 (i) This Option shall be exercisable by delivery of an
exercise notice in the form attached as EXHIBIT A (the “Exercise Notice”), which shall state the election to exercise this Option, the number of Shares with respect to which this Option is being
exercised, and such other representations and agreements as may be required by the Company. The Exercise Notice shall be accompanied by payment of the aggregate Exercise Price as to all Exercised Shares. This Option shall be deemed to be exercised
upon receipt by the Company of such fully executed Exercise Notice accompanied by the aggregate Exercise Price. 
 (ii) No Shares
shall be issued pursuant to the exercise of this Option unless such issuance and such exercise comply with Applicable Laws. Assuming such compliance, for income tax purposes the Shares shall be considered transferred to Optionee on the date on which
this Option is exercised with respect to such Shares. 

  
 2 








 3. OPTIONEE’S REPRESENTATIONS. In the
event the Shares have not been registered under the Securities Act of 1933, as amended, at the time this Option is exercised, Optionee shall, if required by the Company, concurrently with the exercise of all or any portion of this Option, deliver to
the Company his or her or its Investment Representation Statement in the form attached hereto as EXHIBIT B. 

4. Lock-Up Period. 

(a) Optionee hereby agrees that Optionee shall not offer, pledge, sell, contract to sell, sell any option or contract to purchase,
purchase any option or contract to sell, grant any option, right or warrant to purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any Common Stock (or other securities) of the Company or enter into any swap, hedging or
other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of any Common Stock (or other securities) of the Company held by Optionee (other than those included in the registration) during the one
hundred eighty (180) day period (or such longer period as may be requested in writing by the representative of the underwriters of Common Stock (or other securities) of the Company in connection with NASD Rule 2711(f)(4)) following the
effective date of the first registration statement of the Company filed under the Securities Act (the “Lock-Up Period”). 

(b) Optionee agrees to execute and deliver such other agreements (including the underwriter’s standard form of “lock-up”
or “market standoff” agreement) as may be reasonably requested by the Company or the underwriter which are consistent with the foregoing or which are necessary to give further effect thereto. In the event Optionee refuses to execute any
such agreement, Optionee hereby agrees to comply with all of the transfer restrictions set forth above in this Section for an additional 60 days beyond the Lock-Up Period otherwise call for above. In addition, if requested by the Company or the
representative of the underwriters of Common Stock (or other securities) of the Company, Optionee shall provide, within ten (10) days of such request, such information as may be required by the Company or such representative in connection with
the completion of any public offering of the Company’s securities pursuant to a registration statement filed under the Securities Act. The obligations described in this Section shall not apply to a registration relating solely to employee
benefit plans on Form S-1 or Form S-8 or similar forms that may be promulgated in the future, or a registration relating solely to a Commission Rule 145 transaction on Form S-4 or similar forms that may be promulgated in the future. The Company may
impose stop-transfer instructions with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of the Lock-Up Period. Optionee agrees that any transferee of the Option or shares acquired
pursuant to the Option shall be bound by this Section. 
 5. METHOD OF PAYMENT. Payment
of the aggregate Exercise Price shall be by any of the following, or a combination thereof, at the election of Optionee: 
 (a) cash;

 (b) check; 

  
 3 








 (c) consideration received by the Company under a formal cashless exercise program adopted
by the Company in connection with the Plan; or 
 (d) surrender of other shares which, (i) in the case of shares acquired from
the Company, either directly or indirectly, have been owned by Optionee, and not subject to a substantial risk of forfeiture, for more than six (6) months on the date of surrender, and (ii) have a Fair Market Value on the date of surrender
equal to the aggregate Exercise Price of the Exercised Shares. 
 6. RESTRICTIONS ON
EXERCISE. This Option may not be exercised until such time as the Plan has been approved by the stockholders of the Company, or if the issuance of such Shares upon such exercise or the method of payment of consideration for such
shares would constitute a violation of any Applicable Law. 
 7. NON-TRANSFERABILITY OF
OPTION. This Option may not be transferred in any manner otherwise than by will or by the laws of descent or distribution and may be exercised during the lifetime of Optionee only by Optionee. The terms of the Plan and this Option
Agreement shall be binding upon the executors, administrators, heirs, successors and assigns of the Optionee. 
 8. TERM
OF OPTION. This Option may be exercised only within the term set out in the Notice of Grant, and may be exercised during such term only in accordance with the Plan and the terms of this Option. 

9. TAX OBLIGATIONS. 

(a) Withholding Taxes. Optionee agrees to make appropriate arrangements with the Company (or the Parent or Subsidiary employing or
retaining Optionee) for the satisfaction of all Federal, state, local and foreign income and employment tax withholding requirements applicable to the Option exercise. Optionee acknowledges and agrees that the Company may refuse to honor the
exercise and refuse to deliver the Shares if such withholding amounts are not delivered at the time of exercise. 
 (b) Notice of
Disqualifying Disposition of ISO Shares. If this Option granted to Optionee herein is an ISO, and if Optionee sells or otherwise disposes of any of the Shares acquired pursuant to the ISO on or before the later of (1) the date two years
after the Date of Grant, and (2) the date one year after the date of exercise, Optionee shall immediately notify the Company in writing of such disposition. Optionee agrees that Optionee may be subject to income tax withholding by the Company
on the compensation income recognized by Optionee. 
 10. ENTIRE AGREEMENT; GOVERNING
LAW. The Plan is incorporated herein by reference. The Plan and this Option Agreement constitute the entire agreement of the parties with respect to the subject matter hereof and supersede in their entirety all prior undertakings
and agreements of the Company and Optionee with respect to the subject matter hereof, and may not be modified adversely to Optionee’s interest except by means of a writing signed by the Company and Optionee. This Agreement is governed by the
internal substantive laws but not the choice of law rules of Michigan. 

  
 4 








 11. NO GUARANTEE OF CONTINUED
SERVICE. OPTIONEE AGREES THAT THE VESTING OF SHARES PURSUANT TO THE VESTING SCHEDULE HEREOF IS EARNED ONLY BY CONTINUING AS A SERVICE PROVIDER AT THE WILL OF THE COMPANY (NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED THIS
OPTION OR ACQUIRING SHARES HEREUNDER). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT THIS OPTION AGREEMENT, THE TRANSACTIONS CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH HEREIN DO NOT CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF
CONTINUED ENGAGEMENT AS A SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD, OR AT ALL, AND SHALL NOT INTERFERE IN ANY WAY WITH OPTIONEE’S RIGHT OR THE COMPANY’S RIGHT TO TERMINATE OPTIONEE’S RELATIONSHIP AS A SERVICE PROVIDER
AT ANY TIME, WITH OR WITHOUT CAUSE. 
 12. ACKNOWLEDGEMENTS. 

(e) Optionee acknowledges receipt of a copy of the Plan and represents that he, she or it is familiar with the terms and provisions
thereof, and hereby accepts this Option subject to all of the terms and provisions thereof. Optionee has reviewed the Plan and this Option in their entirety, has had an opportunity to obtain the advice of counsel prior to executing this Option and
fully understands all provisions of the Option. Optionee hereby agrees to accept as binding, conclusive and final all decisions or interpretations of the Administrator upon any questions arising under the Plan or this Option. Optionee further agrees
to notify the Company upon any change in the residence address indicated below. 
 (f) Notwithstanding the Board of Directors’
good faith determination of the fair market value of the Common Stock of the Company, the taxing authorities may assert that the fair market value of the Shares on the date of award was greater than the exercise price per share. 

(g) Optionee acknowledges that under Section 409A of the Code, if the exercise price per share of this Option is less than the
fair market value of the Common Stock of the Company on the date of this award, this Option may be treated as a form of deferred compensation and Optionee may be subject to an additional 20% tax, plus interest and possible penalties. Optionee is
encouraged to consult a tax advisor regarding the potential impact of Section 409A of the Code. 
 (h) Optionee acknowledges
that the Administrator, in the exercise of its sole discretion and without Optionee’s consent, may amend or modify this Option in any manner and delay the payment of any amounts payable pursuant to this Option to the minimum extent necessary to
meet the requirements of Section 409A of the Code as amplified by any Internal Revenue Service or U.S. Treasury Department regulations or guidance as the Company deems appropriate or advisable. 

  
 5 









									
	OPTIONEE:						THE COMPANY:
				
							PRONAI THERAPEUTICS, INC.
				
	  
				By:		  

							Name:		
	Date:		  
				Title:		
					
	Resident Address:		  
				Date:		  

				
	  
						


  
 6 








 EXHIBIT A 

2008 STOCK PLAN 

EXERCISE NOTICE 
  

	
	PRONAI THERAPEUTICS, INC.
	  

	  


 Attention: Secretary 

1. EXERCISE OF OPTION. Effective as of today,
[                    ], the undersigned (“Optionee”) hereby elects to exercise Optionee’s option to purchase
[                ] shares of the Common Stock (the “Shares”) of PRONAI THERAPEUTICS,
INC., a Delaware corporation (the “Company”) under and pursuant to the 2008 Stock Plan (the “Plan”) and the Stock Option Agreement dated
                    (the “Option Agreement”). 

2. DELIVERY OF PAYMENT. Optionee herewith delivers to the Company the full purchase price
of the Shares, as set forth in the Option Agreement, and any and all withholding taxes due in connection with the exercise of the Option. 

3. REPRESENTATIONS OF OPTIONEE. Optionee acknowledges that Optionee has received, read and
understood the Plan and the Option Agreement and agrees to abide by and be bound by their terms and conditions. 
 4.
RIGHTS AS STOCKHOLDER. Until the issuance of the Shares (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or
receive dividends or any other rights as a stockholder shall exist with respect to the Optioned Stock, notwithstanding the exercise of the Option. The Shares shall be issued to the Optionee as soon as practicable after the Option is exercised in
accordance with the Option Agreement. No adjustment shall be made for a dividend or other right for which the record date is prior to the date of issuance except as provided in Section 13 of the Plan. 

5. COMPANY’S RIGHT OF FIRST REFUSAL.
Before any Shares held by Optionee or any transferee (either being sometimes referred to herein as the “Holder”) may be sold or otherwise transferred (including transfer by gift or operation of law), the Company or its
assignee(s) shall have a right of first refusal to purchase the Shares on the terms and conditions set forth in this Section (the “Right of First Refusal”). 

(a) Notice of Proposed Transfer. The Holder of the Shares shall deliver to the Company a written notice (the
“Notice”) stating: (i) the Holder’s bona fide intention to sell or otherwise transfer such Shares; (ii) the name of each proposed purchaser or other transferee (each a “Proposed
Transferee”); (iii) the number of Shares to be transferred to each Proposed Transferee; and (iv) the bona fide cash price or other consideration for which the Holder proposes to transfer the Shares (the “Offered
Price”), and the Holder shall offer the Shares at the Offered Price to the Company or its assignee(s). 

  
 1 








 (b) Exercise of Right of First Refusal. At any time within thirty (30) days after
receipt of the Notice, the Company and/or its assignee(s) may, by giving written notice to the Holder, elect to purchase all, but not less than all, of the Shares proposed to be transferred to any one or more of the Proposed Transferees, at the
purchase price determined in accordance with subsection (c) below. 
 (c) Purchase Price. The purchase price (the
“Purchase Price”) for the Shares purchased by the Company or its assignee(s) under this Section shall be the Offered Price. If the Offered Price includes consideration other than cash, the cash equivalent value of the
non-cash consideration shall be determined by the Board of Directors of the Company in good faith. 
 (d) Payment. Payment of the
Purchase Price shall be made, at the option of the Company or its assignee(s), in cash (by check), by cancellation of all or a portion of any outstanding indebtedness of the Holder to the Company (or, in the case of repurchase by an assignee, to the
assignee), or by any combination thereof within 30 days after receipt of the Notice or in the manner and at the times set forth in the Notice. 

(e) Holder’s Right to Transfer. If all of the Shares proposed in the Notice to be transferred to a given Proposed Transferee are
not purchased by the Company and/or its assignee(s) as provided in this Section, then the Holder may sell or otherwise transfer such Shares to that Proposed Transferee at the Offered Price or at a higher price, provided that such sale or other
transfer is consummated within 120 days after the date of the Notice, that any such sale or other transfer is effected in accordance with any applicable securities laws and that the Proposed Transferee agrees in writing that the provisions of this
Section shall continue to apply to the Shares in the hands of such Proposed Transferee. If the Shares described in the Notice are not transferred to the Proposed Transferee within such period, a new Notice shall be given to the Company, and the
Company and/or its assignees shall again be offered the Right of First Refusal before any Shares held by the Holder may be sold or otherwise transferred. 

(f) Exception for Certain Family Transfers. Anything to the contrary contained in this Section notwithstanding, the transfer of any or
all of the Shares during Optionee’s lifetime or on Optionee’s death by will or intestacy to Optionee’s immediate family or a trust for the benefit of the Optionee’s immediate family shall be exempt from the provisions of this
Section. “Immediate Family” as used herein shall mean spouse, lineal descendant or antecedent, father, mother, brother or sister. In such case, the transferee or other recipient shall receive and hold the Shares so
transferred subject to the provisions of this Section, and there shall be no further transfer of such Shares except in accordance with the terms of this Section. 

(g) Termination of Right of First Refusal. The Right of First Refusal shall terminate as to any Shares upon the earlier of
(i) first sale of Common Stock of the Company to the general public, or (ii) a Change in Control in which the successor corporation has equity securities that are publicly traded. 

6. TAX CONSULTATION. Optionee understands that Optionee may suffer adverse tax consequences as a result
of Optionee’s purchase or disposition of the Shares. Optionee represents that Optionee has consulted with any tax consultants Optionee deems advisable in connection with the purchase or disposition of the Shares and that Optionee is not relying
on the Company for any tax advice. 

  
 2 








 7. RESTRICTIVE LEGENDS AND
STOP-TRANSFER ORDERS. 
 (a) Legends. Optionee understands and agrees that the
Company shall cause the legends set forth below or legends substantially equivalent thereto, to be placed upon any certificate(s) evidencing ownership of the Shares together with any other legends that may be required by the Company or by state or
federal securities laws: 
 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE
“ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR, IN THE OPINION OF COUNSEL SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR
TRANSFER, PLEDGE OR HYPOTHECATION IS IN COMPLIANCE THEREWITH. 
 THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
RESTRICTIONS ON TRANSFER AND A RIGHT OF FIRST REFUSAL HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE EXERCISE NOTICE BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF
THE ISSUER. SUCH TRANSFER RESTRICTIONS AND RIGHT OF FIRST REFUSAL ARE BINDING ON TRANSFEREES OF THESE SHARES. 
 THE SHARES REPRESENTED BY
THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON TRANSFER FOR A PERIOD OF 180 DAYS FOLLOWING THE EFFECTIVE DATE OF THE UNDERWRITTEN PUBLIC OFFERING OF THE COMPANY’S SECURITIES (OR FOR SUCH LONGER PERIOD AS PREVIOUSLY AGREED TO BY THE HOLDER OF
THE SHARES) AND MAY NOT BE SOLD OR OTHERWISE DISPOSED OF BY THE HOLDER WITHOUT THE CONSENT OF THE COMPANY. 
 (b) Stop-Transfer
Notices. Optionee agrees that, in order to ensure compliance with the restrictions referred to herein, the Company may issue appropriate “stop transfer” instructions to its transfer agent, if any, and that, if the Company transfers its
own securities, it may make appropriate notations to the same effect in its own records. 
 (c) Refusal to Transfer. The Company
shall not be required (i) to transfer on its books any unvested Shares or Shares that have been sold or otherwise transferred in violation of any of the provisions of this Exercise Notice or (ii) to treat as owner of such Shares or to
accord the right to vote or pay dividends to any purchaser or other transferee to whom such Shares shall have been so transferred. 

  
 3 








 8. SUCCESSORS AND ASSIGNS. The Company may
assign any of its rights under this Exercise Notice to single or multiple assignees, and this Exercise Notice shall inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer herein set forth, this
Exercise Notice shall be binding upon Optionee and his or her heirs, executors, administrators, successors and assigns. 
 9.
INTERPRETATION. Any dispute regarding the interpretation of this Exercise Notice shall be submitted by Optionee or by the Company forthwith to the Administrator, which shall review such dispute at its next regular meeting. The
resolution of such a dispute by the Administrator shall be final and binding on all parties. 
 10. GOVERNING
LAW; SEVERABILITY. This Exercise Notice is governed by the internal substantive laws, but not the choice of law rules, of Michigan. 

11. ENTIRE AGREEMENT. The Plan and Option Agreement are incorporated herein by reference. This Exercise
Notice, the Plan, the Restricted Stock Purchase Agreement, the Option Agreement and the Investment Representation Statement constitute the entire agreement of the parties with respect to the subject matter hereof and supersede in their entirety all
prior undertakings and agreements of the Company and Optionee with respect to the subject matter hereof, and may not be modified adversely to the Optionee’s interest except by means of a writing signed by the Company and Optionee. 

 

									
	Submitted By:				Accepted By:
			
	OPTIONEE:				THE COMPANY:
				
							PRONAI THERAPEUTICS, INC.
				
	  
				By:		  

							Name:		
	Date:		  
				Title:		
					
	Resident Address:		  
				Date:		  

				
	  
						


  
 4 








 EXHIBIT B 

INVESTMENT REPRESENTATION STATEMENT 
  

			
	OPTIONEE:		«NAME»
		
	COMPANY:		PRONAI THERAPEUTICS, INC.
		
	SECURITY:		COMMON STOCK
		
	AMOUNT:		
		
	DATE:		

 In connection with the purchase of the above-listed Securities, the undersigned Optionee represents to the
Company the following: 
 (a) Optionee is aware of the Company’s business affairs and financial condition and has acquired
sufficient information about the Company to reach an informed and knowledgeable decision to acquire the Securities. Optionee is acquiring these Securities for investment for Optionee’s own account only and not with a view to, or for resale in
connection with, any “distribution” thereof within the meaning of the Securities Act of 1933, as amended (the “Securities Act”). 

(b) Optionee acknowledges and understands that the Securities constitute “restricted securities” under the Securities Act and
have not been registered under the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Optionee’s investment intent as expressed herein. In this connection,
Optionee understands that, in the view of the Securities and Exchange Commission, the statutory basis for such exemption may be unavailable if Optionee’s representation was predicated solely upon a present intention to hold these Securities for
the minimum capital gains period specified under tax statutes, for a deferred sale, for or until an increase or decrease in the market price of the Securities, or for a period of one year or any other fixed period in the future. Optionee further
understands that the Securities must be held indefinitely unless they are subsequently registered under the Securities Act or an exemption from such registration is available. Optionee further acknowledges and understands that the Company is under
no obligation to register the Securities. Optionee understands that the certificate evidencing the Securities will be imprinted with any legend required under applicable state securities laws. 

(c) Optionee is familiar with the provisions of Rule 701 and Rule 144, each promulgated under the Securities Act, which, in substance,
permit limited public resale of “restricted securities” acquired, directly or indirectly from the issuer thereof, in a non-public offering subject to the satisfaction of certain conditions. Rule 701 provides that if the issuer qualifies
under Rule 701 at the time of the grant of the Option to the Optionee, the exercise will be exempt from registration under the Securities Act. In the event the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, ninety (90) days thereafter (or such longer period as any market stand-off agreement may require) the Securities exempt under Rule 701 may be resold, subject to the satisfaction of certain


  
 1 








 
of the conditions specified by Rule 144, including: (1) the resale being made through a broker in an unsolicited “broker’s transaction” or in transactions directly with a
market maker (as said term is defined under the Securities Exchange Act of 1934); and, in the case of an affiliate, (2) the availability of certain public information about the Company, (3) the amount of Securities being sold during any
three month period not exceeding the limitations specified in Rule 144(e), and (4) the timely filing of a Form 144, if applicable. 

(d) In the event that the Company does not qualify under Rule 701 at the time of grant of the Option, then the Securities may be resold
in certain limited circumstances subject to the provisions of Rule 144, which requires the resale to occur not less than one year after the later of the date the Securities were sold by the Company or the date the Securities were sold by an
affiliate of the Company, within the meaning of Rule 144; and, in the case of acquisition of the Securities by an affiliate, or by a non-affiliate who subsequently holds the Securities less than two years, the satisfaction of the conditions set
forth in sections (1), (2), (3) and (4) of the paragraph immediately above. 
 (e) Optionee further understands that in the
event all of the applicable requirements of Rule 701 or 144 are not satisfied, registration under the Securities Act, compliance with Regulation A, or some other registration exemption will be required; and that, notwithstanding the fact that Rules
144 and 701 are not exclusive, the Staff of the Securities and Exchange Commission has expressed its opinion that persons proposing to sell private placement securities other than in a registered offering and otherwise than pursuant to Rules 144 or
701 will have a substantial burden of proof in establishing that an exemption from registration is available for such offers or sales, and that such persons and their respective brokers who participate in such transactions do so at their own risk.
Optionee understands that no assurances can be given that any such other registration exemption will be available in such event. 
  

			
	Signature of Optionee
	
	OPTIONEE:
	
	  

		
	Date:		  




  
 2 








 EXHIBIT C-1 

PRONAI THERAPEUTICS, INC. 

2008 STOCK PLAN 

RESTRICTED STOCK PURCHASE AGREEMENT 

THIS RESTRICTED STOCK PURCHASE AGREEMENT (this “Agreement”) is made between «NAME»
(“Purchaser”) and PRONAI THERAPEUTICS, INC., a Delaware corporation (the “Company”) or its assignees of rights hereunder as of
«DATE». Unless otherwise defined herein, the terms defined in the 2008 Stock Plan (the “Plan”) shall have the same defined meanings in this Agreement. 

BACKGROUND 

Pursuant to the exercise of the option granted to Purchaser under the Plan and pursuant to the Option Agreement dated
«DATE» by and between the Company and Purchaser with respect to such grant (the “Option”), which Plan and Option Agreement are hereby incorporated by reference, Purchaser has elected to purchase
«NUMBER» of those shares of Common Stock which have not become vested under the vesting schedule set forth in the Option Agreement (the “Unvested Shares”). The Unvested Shares and the shares subject to the Option
Agreement, which have become vested are sometimes collectively referred to herein as the “Shares.” 

As required by the Option Agreement, as a condition to Purchaser’s election to exercise the option, Purchaser must execute this
Agreement, which sets forth the rights and obligations of the parties with respect to Shares acquired upon exercise of the Option. 

NOW, THEREFORE, in consideration of the foregoing and the terms and conditions set forth herein, the parties
hereby agree as follows: 
 TERMS AND CONDITIONS 

1. REPURCHASE OPTION. 

(a) If Purchaser’s status as a Service Provider is terminated for any reason, including for death and Disability, the Company
shall, upon the date of such termination (as reasonably fixed by the Company), have an irrevocable, exclusive option to repurchase (the “Repurchase Option”) any Unvested Shares at the price paid by Purchaser for such Shares
(the “Repurchase Price”). The Company may exercise its Repurchase Option as to any or all of the Unvested Shares at any time following Purchaser’s termination; provided, however, that without requirement of
further action on the part of either party hereto, the Company’s Repurchase Option shall be deemed to have been automatically exercised as to all Unvested Shares at 5:00 p.m. EST on the date that is 60 days following the date of
Purchaser’s termination, unless the Company declines in writing to exercise its Repurchase Option prior to such time; provided, further, notwithstanding the above, the Company’s Repurchase Option shall not be deemed to have
been automatically exercised, and shall instead be deemed to become temporarily unexercisable as of such time and date, in any case where such automatic exercise would result 

  
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in a violation of applicable law by reason of the Company having insufficient assets to meet its obligations or otherwise, including, without limitation, a violation of any provision of
Section 160 of the Delaware General Corporation Law. The Repurchase Option shall once again be deemed exercisable (or, as provided above, exercised) as soon as a violation of applicable law would not result from its exercise. 

(b) If the Company decides not to exercise its Repurchase Option, it shall notify Purchaser in writing within 60 days of
Purchaser’s termination. If the Company decides to exercise its Repurchase Option, within 90 days from Purchaser’s termination as a Service Provider, the Company shall deliver payment to Purchaser, with a copy to the Escrow Agent (as
defined in Section 2 hereof), by any of the following methods, in the Company’s sole discretion: (i) delivering to Purchaser or Purchaser’s executor a check in the amount of the aggregate Repurchase Price, (ii) canceling an
amount of Purchaser’s indebtedness to the Company equal to the aggregate Repurchase Price, or (iii) any combination of (i) and (ii) such that the combined payment and cancellation of indebtedness equals such aggregate Repurchase
Price. Upon delivery of the payment of the aggregate Repurchase Price in any of the ways described above, the Company shall become the legal and beneficial owner of the Unvested Shares being repurchased and all related rights and interests therein,
and the Company shall have the right to retain and transfer to its own name the number of Unvested Shares being repurchased by the Company. In the event that Purchaser’s continuous status as a Service Provider terminates, and the Company
neither notifies Purchaser within 60 days thereafter of the Company’s decision not to exercise its Repurchase Option, nor delivers payment of the Repurchase Price to Purchaser within 90 days thereafter, then the sole remedy of Purchaser
thereafter shall be to receive the Repurchase Price from the Company in the manner set forth above, and in no case shall Purchaser have any claim of ownership as to any of the Unvested Shares. 

(c) Whenever the Company shall have the right to repurchase Unvested Shares hereunder, the Company may designate and assign one or more
employees, officers, directors or stockholders of the Company or other persons or organizations to exercise all or a part of the Company’s Repurchase Option under this Agreement and purchase all or a part of such Unvested Shares. 

(d) The Company or its assignee must notify Purchaser that it does not elect to exercise the Repurchase Option conferred above by
giving the requisite written notice within 60 days following Purchaser’s termination as a Service Provider to the Company. If the Company or its assignee gives such requisite notice, the Repurchase Option shall terminate. 

(e) The Repurchase Option shall terminate in accordance with the vesting schedule contained in Purchaser’s Option Agreement. 

(f) In the event that the Company’s Repurchase Option is exercised, whether automatically in the manner provided for above or
pursuant to written notice, then upon and following such exercise, the only remaining right of Purchaser under this Agreement shall be the right to receive the Repurchase Price, and Purchaser shall have no right whatsoever to receive the Unvested
Shares. In the event that the Company’s Repurchase Option is terminated, whether by written notice from the Company to Purchaser within 60 days following the termination of Purchaser’s service to the Company; or by reason of the automatic
termination to avoid a 

  
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violation of applicable law described above, then upon and following such termination, the only remaining right of Purchaser under this Agreement shall be the right to receive the Unvested
Shares, and Purchaser have no right whatsoever to receive the Repurchase Price. 
 2. TRANSFERABILITY OF
THE SHARES; ESCROW. 
 (a) Purchaser hereby authorizes and directs the Secretary of
the Company, or such other person designated by the Company, to transfer the Unvested Shares as to which the Repurchase Option has been exercised from Purchaser to the Company. 

(b) To insure the availability for delivery of Purchaser’s Unvested Shares upon repurchase by the
Company pursuant to the Repurchase Option under Section 1, Purchaser hereby appoints the Secretary, or any other person designated by the Company as escrow agent (the “Escrow Agent”), as its attorney-in-fact to sell,
assign and transfer unto the Company, such Unvested Shares, if any, repurchased by the Company pursuant to the Repurchase Option and shall, upon execution of this Agreement, deliver and deposit with the Escrow Agent, the share certificates
representing the Unvested Shares, together with the stock assignment duly endorsed in blank, attached hereto as EXHIBIT C-2. The Unvested Shares and stock assignment shall be held by the Escrow
Agent in escrow, pursuant to the Joint Escrow Instructions of the Company and Purchaser attached as EXHIBIT C-3 hereto, until the Company exercises its Repurchase Option, until such Unvested
Shares are vested, or until such time as this Agreement no longer is in effect. Upon vesting of the Unvested Shares, the Escrow Agent shall promptly deliver to Purchaser the certificate or certificates representing such Shares in the Escrow
Agent’s possession belonging to Purchaser, and the Escrow Agent shall be discharged of all further obligations hereunder; provided, however, that the Escrow Agent shall nevertheless retain such certificate or certificates as Escrow Agent if so
required pursuant to other restrictions imposed pursuant to this Agreement. 
 (c) The Escrow Agent shall be liable for
any act it may do or omit to do with respect to holding the Shares in escrow and while acting in good faith and in the exercise of its judgment. 

(d) Transfer or sale of the Shares is subject to restrictions on transfer imposed by any applicable state and federal securities laws.
Any transferee shall hold such Shares subject to all the provisions hereof and the Exercise Notice executed by Purchaser with respect to any Unvested Shares purchased by Purchaser and shall acknowledge the same by signing a copy of this Agreement.

 3. OWNERSHIP, VOTING RIGHTS, DUTIES. This Agreement shall not affect
in any way the ownership, voting rights or other rights or duties of Purchaser, except as specifically provided herein. 
 4.
LEGENDS. The share certificate evidencing the Shares issued hereunder shall be endorsed with the following legend (in addition to any legend required under applicable federal and state securities laws): 

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN RESTRICTIONS UPON TRANSFER AND RIGHTS OF


  
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REPURCHASE AS SET FORTH IN AN AGREEMENT BETWEEN THE COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY. 

5. ADJUSTMENT FOR STOCK SPLIT. All references to the number of Shares and
the purchase price of the Shares in this Agreement shall be appropriately adjusted to reflect any stock split, stock dividend or other change in the Shares, which may be made by the Company pursuant to Section 13 of the Plan after the date of
this Agreement. 
 6. NOTICES. Notices required hereunder shall be given in person or by registered mail to the
address of Purchaser shown on the records of the Company, and to the Company at their respective principal executive offices. 
 7.
SURVIVAL OF TERMS. This Agreement shall apply to and bind Purchaser and the Company and their respective permitted assignees and transferees, heirs, legatees, executors, administrators and legal
successors. 
 8. SECTION 83(B) ELECTION. 

(a) Purchaser hereby acknowledges that Purchaser has been informed that, with respect to the exercise of an Option for Unvested Shares,
an election (the “Election”) may be filed by Purchaser with the Internal Revenue Service, within thirty (30) days of the purchase of the exercised Shares, electing pursuant to Section 83(b) of the Code to be taxed
currently on any difference between the purchase price of the exercised Shares and their Fair Market Value on the date of purchase. In the case of a Nonstatutory Stock Option, this will result in a recognition of taxable income to Purchaser on the
date of exercise, measured by the excess, if any, of the Fair Market Value of the exercised Shares, at the time the Option is exercised over the purchase price for the exercised Shares. Absent such an Election, taxable income will be measured and
recognized by Purchaser at the time or times on which the Company’s Repurchase Option lapses. In the case of an Incentive Stock Option, such an Election will result in a recognition of income to Purchaser for alternative minimum tax purposes on
the date of exercise, measured by the excess, if any, of the Fair Market Value of the exercised Shares, at the time the option is exercised, over the purchase price for the exercised Shares. Absent such an Election, alternative minimum taxable
income will be measured and recognized by Purchaser at the time or times on which the Company’s Repurchase Option lapses. Purchaser is strongly encouraged to seek the advice of his or her or its own tax consultants in connection with the
purchase of the Shares and the advisability of filing of the Election under Section 83(b) of the Code. A form of Election under Section 83(b) is attached hereto as EXHIBIT C-4 for reference. 

(b) PURCHASER ACKNOWLEDGES THAT IT IS PURCHASER’S SOLE RESPONSIBILITY AND NOT THE COMPANY’S TO FILE TIMELY THE ELECTION UNDER
SECTION 83(b) OF THE CODE, EVEN IF PURCHASER REQUESTS THE COMPANY OR ITS REPRESENTATIVE TO MAKE THIS FILING ON PURCHASER’S BEHALF. 

9. REPRESENTATIONS. Purchaser has reviewed with Purchaser’s own tax advisors the federal, state, local and foreign
tax consequences of this investment and the transactions 

  
 4 








 
contemplated by this Agreement. Purchaser is relying solely on such advisors and not on any statements or representations of the Company or any of its agents. Purchaser understands that he (and
not the Company) shall be responsible for his own tax liability that may arise as a result of this investment or the transactions contemplated by this Agreement. 

10. GOVERNING LAW. This Agreement shall be governed by the internal substantive laws, but not the choice
of law rules, of Michigan. 
 11. REPRESENTATION. Purchaser represents that Purchaser has read this Agreement and is
familiar with its terms and provisions. Purchaser hereby agrees to accept as binding, conclusive and final all decisions or interpretations of the Board upon any questions arising under this Agreement. 

IN WITNESS WHEREOF, this Agreement is deemed made as of the date first set forth above. 

 

									
	PURCHASER:				THE COMPANY:
				
							PRONAI THERAPEUTICS, INC.
				
	  
				By:		  

							Name:		
	Date:		  
				Title:		
					
	Resident Address:		  
				Date:		  

				
	  
						


  
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 EXHIBIT C-2 

ASSIGNMENT SEPARATE FROM CERTIFICATE 

FOR VALUE RECEIVED I, «Name», hereby sell, assign and transfer unto PRONAI
THERAPEUTICS, INC., a Delaware corporation (the “Company”) «Number» («Number») shares of the Common Stock of the Company standing in my name of the books of the Company
represented by Certificate No.    herewith and do hereby irrevocably constitute and appoint the Company’s Secretary to transfer the such stock on the books of the within named corporation with full power of substitution in
the premises. 
 This Stock Assignment may be used only in accordance with the Restricted Stock Purchase Agreement between the
Company and the undersigned dated                     (the “Agreement”). 

 

							
	  
				Dated:		  


 INSTRUCTIONS: Please do not fill in any blanks other than the signature line. The purpose of this assignment
is to enable the Company to exercise its “repurchase option,” as set forth in the Agreement, without requiring additional signatures on the part of Purchaser. 

  
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 EXHIBIT C-3 

JOINT ESCROW INSTRUCTIONS 
  

	
	PRONAI THERAPEUTICS, INC.
	  

	  


 Dear Corporate Secretary: 

As Escrow Agent for both PRONAI THERAPEUTICS, INC., a Delaware corporation (the
“Company”), and the undersigned purchaser of stock of the Company (“Purchaser”), you are hereby authorized and directed to hold the documents delivered to you pursuant to the terms of that certain
Restricted Stock Purchase Agreement (the “Agreement”) between the Company and the undersigned, in accordance with the following instructions: 

1. In the event the Company and/or any assignee of the Company (referred to collectively for convenience
herein as the “Company”) exercises the Company’s repurchase option set forth in the Agreement, the Company shall give to Purchaser and you a written notice specifying the number of shares of stock to be purchased, the
purchase price, and the time for a closing hereunder at the principal office of the Company. Purchaser and the Company hereby irrevocably authorize and direct you to close the transaction contemplated by such notice in accordance with the terms of
said notice. 
 2. At the closing, you are directed (a) to date the stock assignments necessary for the transfer
in question, (b) to fill in the number of shares being transferred, and (c) to deliver the stock assignments, together with the certificate evidencing the shares of stock to be transferred, to the Company or its assignee, against the
simultaneous delivery to you of the purchase price (by cash, a check, or some combination thereof) for the number of shares of stock being purchased pursuant to the exercise of the Company’s repurchase option. 

3. Purchaser irrevocably authorizes the Company to deposit with you any certificates evidencing shares of stock to be held by you
hereunder and any additions and substitutions to said shares as defined in the Agreement. Purchaser does hereby irrevocably constitute and appoint you as Purchaser’s attorney-in-fact and agent for the term of this escrow to execute with respect
to such securities all documents necessary or appropriate to make such securities negotiable and to complete any transaction herein contemplated, including but not limited to the filing with any applicable state blue sky authority of any required
applications for consent to, or notice of transfer of, the securities. Subject to the provisions of this paragraph 3, Purchaser shall exercise all rights and privileges of a stockholder of the Company while the stock is held by you. 

4. Upon written request of Purchaser, but no more than once per calendar year, unless the Company’s repurchase option has been
exercised, you will deliver to Purchaser a certificate or certificates representing so many shares of stock as are not then subject to the Company’s repurchase option. Within 120 days after cessation of Purchaser’s continuous employment by
or services to the Company, or any parent or subsidiary of the Company, you will deliver to Purchaser a certificate or certificates representing the aggregate number of shares held or issued pursuant to the Agreement and not purchased by the Company
or its assignees pursuant to exercise of the Company’s repurchase option. 

  
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 5. If at the time of termination of this escrow you should have in your possession any
documents, securities, or other property belonging to Purchaser, you shall deliver all of the same to Purchaser and shall be discharged of all further obligations hereunder. 

6. Your duties hereunder may be altered, amended, modified or revoked only by a writing signed by all of the parties hereto.

 7. You shall be obligated only for the performance of such duties as are specifically set forth herein and may rely and shall
be protected in relying or refraining from acting on any instrument reasonably believed by you to be genuine and to have been signed or presented by the proper party or parties. You shall not be personally liable for any act you may do or omit to do
hereunder as Escrow Agent or as attorney-in-fact for Purchaser while acting in good faith, and any act done or omitted by you pursuant to the advice of your own attorneys shall be conclusive evidence of such good faith. 

8. You are hereby expressly authorized to disregard any and all warnings given by any of the parties hereto or by any other person or
corporation, excepting only orders or process of courts of law and are hereby expressly authorized to comply with and obey orders, judgments or decrees of any court. In case you obey or comply with any such order, judgment or decree, you shall not
be liable to any of the parties hereto or to any other person, firm or corporation by reason of such compliance, notwithstanding any such order, judgment or decree being subsequently reversed, modified, annulled, set aside, vacated or found to have
been entered without jurisdiction. 
 9. You shall not be liable in any respect on account of the identity, authorities or
rights of the parties executing or delivering or purporting to execute or deliver the Agreement or any documents or papers deposited or called for hereunder. 

10. You shall not be liable for the outlawing of any rights under the Statute of Limitations with respect to these Joint Escrow
Instructions or any documents deposited with you. 
 11. You shall be entitled to employ such legal counsel and other experts
as you may deem necessary properly to advise you in connection with your obligations hereunder, may rely upon the advice of such counsel, and may pay such counsel reasonable compensation therefor. 

12. Your responsibilities as Escrow Agent hereunder shall terminate if you shall cease to be an officer or agent of the Company or if
you shall resign by written notice to each party. In the event of any such termination, the Company shall appoint a successor Escrow Agent. 

13. If you reasonably require other or further instruments in connection with these Joint Escrow Instructions or obligations in respect
hereto, the necessary parties hereto shall join in furnishing such instruments. 
 14. It is understood and agreed that should
any dispute arise with respect to the delivery and/or ownership or right of possession of the securities held by you hereunder, you are 

  
 2 








 
authorized and directed to retain in your possession without liability to anyone all or any part of said securities until such disputes shall have been settled either by mutual written agreement
of the parties concerned or by a final order, decree or judgment of a court of competent jurisdiction after the time for appeal has expired and no appeal has been perfected, but you shall be under no duty whatsoever to institute or defend any such
proceedings. 
 15. Any notice required or permitted hereunder shall be given in writing and shall be deemed effectively given upon
personal delivery or upon deposit in the United States Post Office, by registered or certified mail with postage and fees prepaid, addressed to each of the other parties thereunto entitled at the following addresses or at such other addresses as a
party may designate by ten days’ advance written notice to each of the other parties hereto. 
 16. By signing these Joint
Escrow Instructions, you become a party hereto only for the purpose of said Joint Escrow Instructions; you do not become a party to the Agreement. 

17. This instrument shall be binding upon and inure to the benefit of the parties hereto, and their respective successors and permitted
assigns. 
 18. These Joint Escrow Instructions shall be governed by the internal substantive laws, but not the choice of law rules,
of Michigan. 
  

			
	Very truly yours,
	
	PRONAI THERAPEUTICS, INC.
		
	By:		  

	  

		
	Title:		  

	  

	
	PURCHASER:
	
	(Signature)
	
	(Typed or Printed Name)



  
 3 








 ESCROW AGENT: 

[Corporate Secretary] 

  
 4 








 EXHIBIT C-4 

ELECTION UNDER SECTION 83(b) 

OF THE INTERNAL REVENUE CODE OF 1986 

The undersigned taxpayer hereby elects, pursuant to Sections 55 and 83(b) of the Internal Revenue Code of 1986, as amended, to include in
taxpayer’s gross income or alternative minimum taxable income, as the case may be, for the current taxable year the amount of any compensation taxable to taxpayer in connection with taxpayer’s receipt of the property described below 

1. The name, address, taxpayer identification number and taxable year of the undersigned are as follows: 

 

			
	NAME OF TAXPAYER: «Name»		SPOUSE:
		
	  ADDRESS:		
		
	  IDENTIFICATION NO. OF TAXPAYER:		SPOUSE:
		
	  TAXABLE YEAR:		

 2. The property with respect to which the election is made is described as follows:
                 shares (the “Shares”) of the Common Stock of PRONAI THERAPEUTICS,
INC. (the “Company”). 
 3. The date on which the property was transferred is:
                    . 
 4. The
property is subject to the following restrictions: 
 The Shares may not be transferred and are subject to forfeiture under the terms of an
agreement between the taxpayer and the Company. These restrictions lapse upon the satisfaction of certain conditions contained in such agreement. 

5. The fair market value at the time of transfer, determined without regard to any restriction other than a restriction which by its
terms will never lapse, of such property is: $        . 
 6. The amount (if any) paid for
such property is: $        . 
 The undersigned has submitted a copy of this statement to the person
for whom the services were performed in connection with the undersigned’s receipt of the above-described property. The transferee of such property is the person performing the services in connection with the transfer of said property. 

  
 1 








 The undersigned understands that the foregoing election may not be revoked except with the
consent of the Commissioner. 
  

							
	Dated:                     ,         						
					  
		
					                    , Taxpayer		
	The undersigned spouse of taxpayer joins in this election.						
				
	Dated:                     ,         						
				
					Spouse of Taxpayer		


  
 2 








 PRONAI THERAPEUTICS, INC. 

2008 STOCK PLAN 

RESTRICTED STOCK PURCHASE AGREEMENT 

Unless otherwise defined herein, the terms defined in the 2008 Stock Plan (the “Plan”) will have the
same defined meanings in this Restricted Stock Purchase Agreement (this “Agreement”). 
  

	I.	NOTICE OF GRANT OF STOCK PURCHASE RIGHT 

 Name: 

The undersigned Purchaser has been granted a right to purchase Common Stock of the Company, subject to the terms and conditions of the Plan and
this Agreement, as follows: 
  

			
	Date of Grant:		
		
	Vesting Commencement Date:		
		
	Exercise Price Per Share:		$
		
	Total Number of Shares:		
		
	Expiration Date:		

 YOU MUST EXERCISE THIS STOCK PURCHASE RIGHT BEFORE THE EXPIRATION DATE OR IT WILL TERMINATE AND YOU WILL HAVE
NO FURTHER RIGHT TO PURCHASE THE SHARES. 
 Non-Transferability of Stock Purchase Right. 

The Stock Purchase Right evidenced by this Agreement may not be transferred in any manner otherwise than by will or by the laws of descent or
distribution and may be exercised during the lifetime of Purchaser only by Purchaser. The terms of the Plan and this Agreement will be binding upon the executors, administrators, heirs, successors and assigns of Purchaser. 

 

	II.	AGREEMENT 

 1. SALE OF STOCK. The
Company hereby agrees to sell to the individual named in the Notice of Grant of Stock Purchase Right (“Purchaser”), and Purchaser hereby agrees to purchase the number of Shares set forth in the Notice of Grant of Stock
Purchase Right, at the exercise price per share set forth in the Notice of Grant of Stock Purchase Right (the “Exercise Price”), and subject to the terms and conditions of the Plan, which is incorporated herein by reference.
Subject to Section 15(c) of the Plan, in the event of a conflict between the terms and conditions of the Plan and this Agreement, the terms and conditions of the Plan will prevail. 

  
 1 








 2. PAYMENT OF PURCHASE PRICE.
Purchaser herewith delivers to the Company the aggregate Exercise Price for the Shares by cash or check, together with any and all withholding taxes due in connection with the purchase of the Shares. 

3. PURCHASER’S REPRESENTATIONS. In the event the Shares have not been registered
under the Securities Act of 1933, as amended, at the time the Stock Purchase Right evidenced by this Agreement is exercised, Purchaser will, if required by the Company, concurrently with the exercise of all or any portion of this Stock Purchase
Right, deliver to the Company his or her Investment Representation Statement in the form attached hereto as EXHIBIT B. 

4. REPURCHASE OPTION. 

(a) In the event Purchaser’s continuous status as a Service Provider terminates for any or no reason (including death or
Disability), the Company will, upon the date of such termination (as reasonably fixed and determined by the Company), have an irrevocable, exclusive option for a period of ninety (90) days from such date to repurchase up to that number of
Shares which constitute the Unreleased Shares (as defined in Section 5) at the Exercise Price per share (the “Repurchase Price”) (the “Repurchase Option”). 

(b) The Repurchase Option will be exercised by the Company by delivering written notice to Purchaser or Purchaser’s executor (with
a copy to the Escrow Holder (as defined in Section 7)) AND, at the Company’s option, (i) by delivering to Purchaser or Purchaser’s executor a check in the amount of the aggregate Repurchase Price, or (ii) by the Company
canceling an amount of Purchaser’s indebtedness to the Company equal to the aggregate Repurchase Price, or (iii) by a combination of (i) and (ii) so that the combined payment and cancellation of indebtedness equals such aggregate
Repurchase Price. Upon delivery of such notice and the payment of the aggregate Repurchase Price in any of the ways described above, the Company will become the legal and beneficial owner of the Unreleased Shares being repurchased and all rights and
interests therein or relating thereto, and the Company will have the right to retain and transfer to its own name the number of Unreleased Shares being repurchased by the Company. 

(c) Whenever the Company will have the right to repurchase the Unreleased Shares hereunder, the Company may
designate and assign one or more employees, officers, directors or shareholders of the Company or other persons or organizations to exercise all or a part of the Company’s Repurchase Option to purchase all or a part of the Unreleased Shares. If
the Fair Market Value of the Unreleased Shares to be repurchased on the date of such designation or assignment (the “Repurchase FMV”) exceeds the aggregate Repurchase Price of the Unreleased Shares, then each such designee or
assignee will pay the Company cash equal to the difference between the Repurchase FMV and the aggregate Repurchase Price of Unreleased Shares to be purchased. 

  
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 (d) If the Company or its assignee does not elect to exercise the Repurchase Option
conferred above by giving the requisite notice within ninety (90) days following Purchaser’s termination as a Service Provider, the Repurchase Option will terminate. 

5. RELEASE OF SHARES FROM REPURCHASE OPTION.

 (a) Subject to any accelerated vesting provisions in the Plan, [1/4th of
the Shares subject to the Repurchase Option will be released on the first anniversary of the Vesting Commencement Date and 1/48 of the Shares subject to the Repurchase Option will be released monthly thereafter] (as set forth in the Notice of Grant
of Stock Purchase Right), subject to Purchaser continuing to be a Service Provider through each such date. 
 (b) Any of the Shares
which have not yet been released from the Company’s Repurchase Option are referred to herein as “Unreleased Shares.” 

(c) The Shares which have been released from the Company’s Repurchase Option will be delivered to Purchaser at Purchaser’s
request (see Section 7). 
 6. RESTRICTION ON TRANSFER. Except for the escrow described
in Section 7 or transfer of the Shares to the Company or its assignees contemplated by this Agreement, none of the Shares or any beneficial interest therein will be transferred, encumbered or otherwise disposed of in any way until the release
of such Shares from the Company’s Repurchase Option in accordance with the provisions of this Agreement, other than by will or the laws of descent and distribution. 

7. ESCROW OF SHARES. 

(a) To ensure the availability for delivery of Purchaser’s Unreleased Shares upon exercise of the Repurchase Option by the
Company, Purchaser will, upon execution of this Agreement, deliver and deposit with an escrow agent designated by the Company (the “Escrow Agent”) the share certificates representing the Unreleased Shares, together with the
Assignment Separate from Certificate (the “Stock Assignment”) duly endorsed in blank, attached hereto as EXHIBIT A-1. The Unreleased Shares and Stock Assignment will be held by the Escrow Agent,
pursuant to the Joint Escrow Instructions of the Company and Purchaser attached as EXHIBIT A-2 hereto, until such time as the Company’s Repurchase Option expires. 

(b) The Escrow Agent will not be liable for any act it may do or omit to do with respect to holding the Unreleased Shares in escrow and
while acting in good faith and in the exercise of its judgment. 
 (c) If the Company or any assignee exercises its Repurchase Option
hereunder, the Escrow Agent, upon receipt of written notice of such option exercise from the proposed transferee, will take all steps necessary to accomplish such transfer. 

(d) When the Repurchase Option has been exercised or expires unexercised or a portion of the Shares has been released from such
Repurchase Option, upon Purchaser’s request the Escrow Agent will promptly cause a new certificate to be issued for such released Shares and will deliver such certificate to the Company or Purchaser, as the case may be. 

  
 3 








 (e) Subject to the terms hereof, Purchaser will have all the rights of a shareholder with
respect to such Shares while they are held in escrow, including without limitation, the right to vote the Shares and receive any cash dividends declared thereon. If, from time to time during the term of the Company’s Repurchase Option, there is
(i) any stock dividend, stock split or other change in the Shares, or (ii) any merger or sale of all or substantially all of the assets or other acquisition of the Company, any and all new, substituted or additional securities to which
Purchaser is entitled by reason of Purchaser’s ownership of the Shares will be immediately subject to this escrow, deposited with the Escrow Agent and included thereafter as “Shares” for purposes of this Agreement and the
Company’s Repurchase Option. 
 8. COMPANY’S RIGHT OF
FIRST REFUSAL. Subject to Section 6, before any Shares held by Purchaser or any transferee (either being sometimes referred to herein as the “Holder”) may be sold or otherwise
transferred (including transfer by gift or operation of law), the Company or its assignee(s) will have a right of first refusal to purchase the Shares on the terms and conditions set forth in this Section (the “Right of First
Refusal”). 
 (a) Notice of Proposed Transfer. The Holder of the Shares will deliver to the Company a written
notice (the “Notice”) stating: (i) the Holder’s bona fide intention to sell or otherwise transfer such Shares; (ii) the name of each proposed purchaser or other transferee (“Proposed
Transferee”); (iii) the number of Shares to be transferred to each Proposed Transferee; and (iv) the bona fide cash price or other consideration for which the Holder proposes to transfer the Shares (the “Offered
Price”), and the Holder will offer the Shares at the Offered Price to the Company or its assignee(s). 
 (b) Exercise
of Right of First Refusal. At any time within thirty (30) days after receipt of the Notice, the Company and/or its assignee(s) may, by giving written notice to the Holder, elect to purchase all, but not less than all, of the Shares proposed
to be transferred to any one or more of the Proposed Transferees, at the purchase price determined in accordance with subsection (c) below. 

(c) Purchase Price. The purchase price (the “Purchase Price”) for the Shares purchased by the Company or
its assignee(s) under this Section will be the Offered Price. If the Offered Price includes consideration other than cash, the cash equivalent value of the non-cash consideration will be determined by the Board of Directors of the Company in good
faith. 
 (d) Payment. Payment of the Purchase Price will be made, at the option of the Company or its assignee(s),
(i) by cash or check, (ii) by cancellation of all or a portion of any outstanding indebtedness of the Holder to the Company (or, in the case of repurchase by an assignee, to the assignee), or (iii) by any combination thereof within
thirty (30) days after receipt of the Notice or in the manner and at the times set forth in the Notice. 
 (e) Holder’s
Right to Transfer. If all of the Shares proposed in the Notice to be transferred to a given Proposed Transferee are not purchased by the Company and/or its assignee(s) as provided in this Section, then the Holder may sell or otherwise transfer
such Shares to that Proposed Transferee at the Offered Price or at a higher price, provided that such sale or other transfer is consummated within ninety (90) days after the date of the Notice and provided further that any such sale or other
transfer is effected in accordance with any applicable 

  
 4 








 
securities laws and the Proposed Transferee agrees in writing that the provisions of this Section will continue to apply to the Shares in the hands of such Proposed Transferee. If the Shares
described in the Notice are not transferred to the Proposed Transferee within such period, a new Notice will be given to the Company, and the Company and/or its assignees will again be offered the Right of First Refusal before any Shares held by the
Holder may be sold or otherwise transferred. 
 (f) Exception for Certain Family Transfers. Anything to the contrary contained in
this Section notwithstanding, the transfer of any or all of the Shares during Purchaser’s lifetime or on Purchaser’s death by will or intestacy to Purchaser’s immediate family or a trust for the benefit of Purchaser’s immediate
family will be exempt from the provisions of this Section, provided that Purchaser notifies the Company in writing within thirty (30) days of said transfer. “Immediate Family” as used herein will mean spouse, lineal descendant or
antecedent, father, mother, brother or sister. In such case, the transferee or other recipient will receive and hold the Shares so transferred subject to the provisions of this Agreement, including but not limited to this Section 8 and
Section 4, and there will be no further transfer of such Shares except in accordance with the terms of this Section. 
 (g)
Termination of Right of First Refusal. The Right of First Refusal will terminate as to any Shares upon the earlier of (i) the first sale of Common Stock of the Company to the general public, or (ii) a Change in Control in which the
successor corporation has equity securities that are publicly traded. 
 9. RESTRICTIVE LEGENDS;
STOP-TRANSFER ORDERS; REFUSAL TO TRANSFER. 

(a) Purchaser understands and agrees that the Company will cause the legends set forth below or legends substantially equivalent
thereto, to be placed upon any certificate(s) evidencing ownership of the Shares together with any other legends that may be required by the Company or by applicable state or federal securities laws: 

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD
OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR, IN THE OPINION OF COUNSEL SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS IN COMPLIANCE
THEREWITH. 
 THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN RESTRICTIONS ON TRANSFER, A RIGHT OF FIRST REFUSAL, AND A
REPURCHASE OPTION HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE RESTRICTED STOCK PURCHASE AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE ISSUER. SUCH
TRANSFER RESTRICTIONS, RIGHT OF FIRST REFUSAL AND REPURCHASE OPTION ARE BINDING ON TRANSFEREES OF THESE SHARES. 

  
 5 








 THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO RESTRICTION ON TRANSFER FOR A PERIOD OF
180 DAYS FOLLOWING THE EFFECTIVE DATE OF THE COMPANY’S INITIAL UNDERWRITTEN PUBLIC OFFERING AND MAY NOT BE SOLD OR OTHERWISE DISPOSED OF BY THE HOLDER WITHOUT THE CONSENT OF THE COMPANY OR THE MANAGING UNDERWRITER. 

(b) Stop-Transfer Notices. Purchaser agrees that, in order to ensure compliance with the restrictions referred to herein, the Company
may issue appropriate “stop transfer” instructions to its transfer agent, if any, and that, if the Company transfers its own securities, it may make appropriate notations to the same effect in its own records. 

(c) Refusal to Transfer. The Company will not be required (i) to transfer on its books any Shares that have been sold or otherwise
transferred in violation of any of the provisions of this Agreement or (ii) to treat as owner of such Shares or to accord the right to vote or pay dividends to any purchaser or other transferee to whom such Shares will have been so transferred.

 10. LOCK-UP PERIOD. 

(a) Purchaser hereby agrees that Purchaser will not offer, pledge, sell, contract to sell, sell any option or contract to purchase,
purchase any option or contract to sell, grant any option, right or warrant to purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any Common Stock (or other securities, including, without limitation, the Shares) of the
Company or enter into any swap, hedging or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of any Common Stock (or other securities) of the Company held by Purchaser (other than those
included in the registration) for a period specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed one hundred eighty (180) days following the effective date of a registration
statement of the Company filed under the Securities Act. 
 (b) Purchaser agrees to execute and deliver such other agreements as may
be reasonably requested by the Company or the underwriter which are consistent with the foregoing or which are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of Common
Stock (or other securities) of the Company, Purchaser will provide, within ten (10) days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the
Company’s securities pursuant to a registration statement filed under the Securities Act. The obligations described in this Section will not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar
forms that may be promulgated in the future, or a registration relating solely to a Commission Rule 145 transaction on Form S-4 or similar forms that may be promulgated in the future. The Company may impose stop-transfer instructions with respect to
the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of said one hundred eighty (180) day period. Purchaser agrees that any transferee of any Option will be bound by this Section. 

  
 6 








 11. TAX CONSEQUENCES. 

(a) Set forth below is a brief summary as of the date of grant of the Stock Purchase Right evidenced by this Agreement of some of the
federal tax consequences of exercise of this Stock Purchase Right and disposition of the Shares. THIS SUMMARY IS NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE. 

(b) Generally, no income will be recognized by Purchaser in connection with the exercise of the stock purchase right for shares subject
to the Repurchase Option, if an election under Section 83(b) of the Code is filed with the Internal Revenue Service within thirty (30) days of the date of exercise of the right to purchase stock. The form for making this election is
attached as EXHIBIT A-3 hereto. Otherwise, as the Company’s repurchase right lapses, Purchaser will recognize compensation income in an amount equal to the difference between the Fair Market Value of the stock at the
time the Company’s repurchase right lapses and the amount paid for the stock, if any (the “Spread”). If Purchaser is an Employee or former Employee, the Spread will be subject to tax withholding by the Company, and the
Company will be entitled to a tax deduction in the amount at the time Purchaser recognizes ordinary income with respect to a Stock Purchase Right. Purchaser agrees to make appropriate arrangements with the Company (or the Parent or Subsidiary
employing or retaining Purchaser) for the satisfaction of all Federal, state, and local income and employment tax withholding requirements applicable to the purchase of Shares hereunder. Purchaser acknowledges and agrees that the Company may refuse
to honor the exercise and refuse to deliver Shares if such withholding amounts are not delivered at the time of purchase. 
 (c) The
Administrator, in its sole discretion and pursuant to such procedures as it may specify from time to time, may permit Purchaser to satisfy such tax withholding obligation, in whole or in part by one or more of the following (without limitation):
(i) paying cash, (ii) electing to have the Company withhold otherwise deliverable Shares having a Fair Market Value equal to the minimum amount required to be withheld, (iii) delivering to the Company already vested and owned Shares
having a Fair Market Value equal to the amount required to be withheld, or (iv) selling a sufficient number of such Shares otherwise deliverable to Purchaser such means as the Company may determine in its sole discretion (whether through a
broker or otherwise) equal to the amount required to be withheld. 
 (d) PURCHASER ACKNOWLEDGES THAT IT IS PURCHASER’S SOLE
RESPONSIBILITY AND NOT THE COMPANY’S TO FILE TIMELY THE ELECTION UNDER SECTION 83(b), EVEN IF PURCHASER REQUESTS THE COMPANY OR ITS REPRESENTATIVES TO MAKE THIS FILING ON THE PURCHASER’S BEHALF. 

12. NO GUARANTEE OF CONTINUED SERVICE. PURCHASER
ACKNOWLEDGES AND AGREES THAT THE RELEASE OF SHARES FROM THE REPURCHASE OPTION OF THE COMPANY PURSUANT TO SECTION 5 HEREOF IS EARNED ONLY BY CONTINUING SERVICE AS SERVICE PROVIDER AT THE WILL OF THE COMPANY


  
 7 








 
(NOT THROUGH THE ACT OF BEING HIRED OR PURCHASING SHARES HEREUNDER). PURCHASER FURTHER ACKNOWLEDGES AND AGREES THAT THIS AGREEMENT, THE TRANSACTIONS CONTEMPLATED HEREUNDER AND THE VESTING
SCHEDULE SET FORTH HEREIN DO NOT CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF CONTINUED ENGAGEMENT AS A SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD, OR AT ALL, AND WILL NOT INTERFERE WITH PURCHASER’S RIGHT OR THE COMPANY’S RIGHT
TO TERMINATE PURCHASER’S RELATIONSHIP AS A SERVICE PROVIDER AT ANY TIME, WITH OR WITHOUT CAUSE. 
 13. NOTICES.
Any notice, demand or request required or permitted to be given by either the Company or Purchaser pursuant to the terms of this Agreement will be in writing and will be deemed given when delivered personally or deposited in the U.S. mail, First
Class with postage prepaid, and addressed to the parties at the addresses of the parties set forth at the end of this Agreement or such other address as a party may request by notifying the other in writing. Any notice to the Escrow Holder will be
sent to the Company’s address with a copy to the other party not sending the notice. 
 14. NO
WAIVER. Either party’s failure to enforce any provision or provisions of this Agreement will not in any way be construed as a waiver of any such provision or provisions, nor prevent that party from thereafter enforcing each
and every other provision of this Agreement. The rights granted both parties herein are cumulative and will not constitute a waiver of either party’s right to assert all other legal remedies available to it under the circumstances. 

15. SUCCESSORS AND ASSIGNS. The Company may assign any of its rights under this Agreement
to single or multiple assignees, and this Agreement will inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer herein set forth, this Agreement will be binding upon Purchaser and Purchaser’s
heirs, executors, administrators, successors and assigns. 
 16. INTERPRETATION. Any dispute regarding the
interpretation of this Agreement will be submitted by Purchaser or by the Company forthwith to the Administrator which will review such dispute at its next regular meeting. The resolution of such a dispute by the Administrator will be final and
binding on all parties. 
 17. GOVERNING LAW; SEVERABILITY. This Agreement is governed
by the internal substantive laws but not the choice of law rules, of Michigan. 
 18. ENTIRE AGREEMENT.
The Plan is incorporated herein by reference. This Agreement (including the exhibits referenced herein), the Plan, and the Investment Representation Statement constitute the entire agreement of the parties with respect to the subject matter hereof
and supersede in their entirety all prior undertakings and agreements of the Company and Purchaser with respect to the subject matter hereof, and may not be modified adversely to Purchaser’s interest except by means of a writing signed by the
Company and Purchaser. 

  
 8 








 19. REPRESENTATIONS. By Purchaser’s signature below, Purchaser
represents that Purchaser is familiar with the terms and provisions of the Plan, and hereby accepts this Agreement subject to all of the terms and provisions thereof. Purchaser has reviewed the Plan and this Agreement in their entirety, has had an
opportunity to obtain the advice of counsel prior to executing this Agreement and fully understands all provisions of this Agreement. Purchaser agrees to accept as binding, conclusive and final all decisions or interpretations of the Administrator
upon any questions arising under the Plan or this Agreement. Purchaser further agrees to notify the Company upon any change in the residence indicated in the Notice of Grant of Stock Purchase Right. 

IN WITNESS WHEREOF, this Agreement is deemed made as of the date first set forth above. 

 

									
	PURCHASER:						THE COMPANY:
				
							PRONAI THERAPEUTICS, INC.
				
	  
				By:		  

							Name:		Robert Forgey
	Date:		  
				Title:		President
					
	Resident Address:		  
				Date:		  

				
	  
						


  
 9 








 EXHIBIT A-1 

ASSIGNMENT SEPARATE FROM CERTIFICATE 

FOR VALUE RECEIVED I, «Name», hereby sell, assign and transfer unto ProNAi THERAPEUTICS, INC., a
Delaware corporation (the “Company”) «Number» («Number») shares of the Common Stock of the Company standing in my name of the books of the Company represented by Certificate No.
     herewith and do hereby irrevocably constitute and appoint the Company’s Secretary to transfer the such stock on the books of the within named corporation with full power of substitution in the premises. 

This Stock Assignment may be used only in accordance with the Restricted Stock Purchase Agreement between the Company and the
undersigned dated                      (the “Agreement”). 

 

							
	  
				Dated:		  


 INSTRUCTIONS: Please do not fill in any blanks other than the signature line. The purpose of this assignment
is to enable the Company to exercise its “repurchase option,” as set forth in the Agreement, without requiring additional signatures on the part of Purchaser. 

  
 1 








 EXHIBIT A-2 

JOINT ESCROW INSTRUCTIONS 
  

	
	                    ,         
	
	PRONAI THERAPEUTICS, INC.
	  

	  

	 Attention: [Corporate Secretary]


 Dear [Corporate Secretary]: 

As Escrow Agent for both ProNAi Therapeutics, Inc., a Delaware corporation (the “Company”) and the
undersigned purchaser of stock of the Company (“Purchaser”), you are hereby authorized and directed to hold the documents delivered to you pursuant to the terms of that certain Restricted Stock Purchase Agreement (the
“Agreement”) between the Company and the undersigned, in accordance with the following instructions: 

1. In the event the Company and/or any assignee of the Company (referred to collectively for convenience
herein as the “Company”) exercises the Company’s repurchase option set forth in the Agreement (the “Repurchase Option”), the Company will give to Purchaser and you a written notice specifying the
number of shares of stock to be purchased, the purchase price, and the time for a closing hereunder at the principal office of the Company. Purchaser and the Company hereby irrevocably authorize and direct you to close the transaction contemplated
by such notice in accordance with the terms of said notice. 
 2. At the closing, you are directed (a) to date the
stock assignments necessary for the transfer in question, (b) to fill in the number of shares being transferred, and (c) to deliver same, together with the certificate evidencing the shares of stock to be transferred, to the Company or its
assignee, against the simultaneous delivery to you of the purchase price (by cash, a check, or some combination thereof) for the number of shares of stock being purchased pursuant to the exercise of the Company’s Repurchase Option. 

3. Purchaser irrevocably authorizes the Company to deposit with you any certificates evidencing shares of stock to be held by you
hereunder and any additions and substitutions to said shares as defined in the Agreement. Purchaser does hereby irrevocably constitute and appoint you as Purchaser’s attorney-in-fact and agent for the term of this escrow to execute with respect
to such securities all documents necessary or appropriate to make such securities negotiable and to complete any transaction herein contemplated, including but not limited to the filing with any applicable state blue sky authority of any required
applications for consent to, or notice of transfer of, the securities. Subject to the provisions of this paragraph 3, Purchaser will exercise all rights and privileges of a shareholder of the Company while the stock is held by you. 

4. Upon written request of Purchaser, but no more than once per calendar year, unless the Company’s Repurchase Option has been
exercised, you will deliver to Purchaser a certificate or certificates representing so many shares of stock as are not then subject to the  

  
 1 








 
Company’s Repurchase Option. Within ninety (90) days after cessation of Purchaser’s continuous employment by or services to the Company, or any parent or subsidiary of the Company,
you will deliver to Purchaser a certificate or certificates representing the aggregate number of shares held or issued pursuant to the Agreement and not purchased by the Company or its assignees pursuant to exercise of the Company’s Repurchase
Option. 
 5. If at the time of termination of this escrow you should have in your possession any documents, securities, or other
property belonging to Purchaser, you will deliver all of the same to Purchaser and will be discharged of all further obligations hereunder. 

6. Your duties hereunder may be altered, amended, modified or revoked only by a writing signed by all of the parties hereto.

 7. You will be obligated only for the performance of such duties as are specifically set forth herein and may rely and will be
protected in relying or refraining from acting on any instrument reasonably believed by you to be genuine and to have been signed or presented by the proper party or parties. You will not be personally liable for any act you may do or omit to do
hereunder as Escrow Agent or as attorney-in-fact for Purchaser while acting in good faith, and any act done or omitted by you pursuant to the advice of your own attorneys will be conclusive evidence of such good faith. 

8. You are hereby expressly authorized to disregard any and all warnings given by any of the parties hereto or by any other person or
corporation, excepting only orders or process of courts of law and are hereby expressly authorized to comply with and obey orders, judgments or decrees of any court. In case you obey or comply with any such order, judgment or decree, you will not be
liable to any of the parties hereto or to any other person, firm or corporation by reason of such compliance, notwithstanding any such order, judgment or decree being subsequently reversed, modified, annulled, set aside, vacated or found to have
been entered without jurisdiction. 
 9. You will not be liable in any respect on account of the identity, authorities or
rights of the parties executing or delivering or purporting to execute or deliver the Agreement or any documents or papers deposited or called for hereunder. 

10. You will not be liable for the outlawing of any rights under the Statute of Limitations with respect to these Joint Escrow
Instructions or any documents deposited with you. 
 11. You will be entitled to employ such legal counsel and other experts
as you may deem necessary properly to advise you in connection with your obligations hereunder, may rely upon the advice of such counsel, and may pay such counsel reasonable compensation therefor. 

12. Your responsibilities as Escrow Agent hereunder will terminate if you will cease to be an officer or agent of the Company or if you
will resign by written notice to each party. In the event of any such termination, the Company will appoint a successor Escrow Agent. 

13. If you reasonably require other or further instruments in connection with these Joint Escrow Instructions or obligations in respect
hereto, the necessary parties hereto will join in furnishing such instruments. 

  
 2 








 14. It is understood and agreed that should any dispute arise with respect to the delivery
and/or ownership or right of possession of the securities held by you hereunder, you are authorized and directed to retain in your possession without liability to anyone all or any part of said securities until such disputes will have been settled
either by mutual written agreement of the parties concerned or by a final order, decree or judgment of a court of competent jurisdiction after the time for appeal has expired and no appeal has been perfected, but you will be under no duty whatsoever
to institute or defend any such proceedings. 
 15. Any notice required or permitted hereunder will be given in writing and
will be deemed effectively given upon personal delivery or upon deposit in the United States Post Office, by registered or certified mail with postage and fees prepaid, addressed to each of the other parties thereunto entitled at the following
addresses or at such other addresses as a party may designate by ten (10) days advance written notice to each of the other parties hereto. 
  

					
	THE COMPANY:		PRONAI THERAPEUTICS, INC.		
			  
		
			  
		
			Attention: [Corporate Secretary]		
			
	PURCHASER:				
			
			Address		
			
	ESCROW		PRONAI THERAPEUTICS, INC.		
	AGENT:		  
		
			  
		
			Attention: [Corporate Secretary]		

 16. By signing these Joint Escrow Instructions, you become a party hereto only for the purpose of said
Joint Escrow Instructions; you do not become a party to the Agreement. 
 17. This instrument will be binding upon and inure
to the benefit of the parties hereto, and their respective successors and permitted assigns. 
 18. The Restricted Stock
Purchase Agreement is incorporated herein by reference. These Joint Escrow Instructions, the 2008 Stock Plan, and the Restricted Stock Purchase Agreement (including the exhibits referenced therein) constitute the entire agreement of the parties with
respect to the subject matter hereof and supersede in their entirety all prior undertakings and agreements of the Escrow Agent, Purchaser and the Company with respect to the subject matter hereof, and may not be modified except by means of a writing
signed by the Escrow Agent, Purchaser and the Company. 

  
 3 








 19. These Joint Escrow Instructions will be governed by, and construed and enforced in
accordance with, the laws of the State of Michigan. 
  

			
	Very truly yours,
	
	PRONAI THERAPEUTICS, INC.
		
	By:		  

	  

		
	Title:		  

	  

	
	PURCHASER:
	
	(Signature)
	
	(Typed or Printed Name)


  

	
	ESCROW AGENT:
	
	[Corporate Secretary]


  
 4 








 EXHIBIT A-3 

ELECTION UNDER SECTION 83(b) 

OF THE INTERNAL REVENUE CODE OF 1986 

The undersigned taxpayer hereby elects, pursuant to Sections 55 and 83(b) of the Internal Revenue Code of 1986, as amended, to include in
taxpayer’s gross income or alternative minimum taxable income, as the case may be, for the current taxable year the amount of any compensation taxable to taxpayer in connection with taxpayer’s receipt of the property described below 

1. The name, address, taxpayer identification number and taxable year of the undersigned are as follows: 

 

			
	NAME OF TAXPAYER: «Name»		SPOUSE:
	  ADDRESS:		
	  IDENTIFICATION NO. OF TAXPAYER:		SPOUSE:
	  TAXABLE YEAR:		

 2. The property with respect to which the election is made is described as follows:
                 shares (the “Shares”) of the Common Stock of PRONAI THERAPEUTICS,
INC. (the “Company”). 
 3. The date on which the property was transferred is:
                    . 
 4. The
property is subject to the following restrictions: 
 The Shares may not be transferred and are subject to forfeiture under the terms of an
agreement between the taxpayer and the Company. These restrictions lapse upon the satisfaction of certain conditions contained in such agreement. 

5. The fair market value at the time of transfer, determined without regard to any restriction other than a restriction which by its
terms will never lapse, of such property is: $        . 
 6. The amount (if any) paid
for such property is: $        . 
 The undersigned has submitted a copy of this statement to the
person for whom the services were performed in connection with the undersigned’s receipt of the above-described property. The transferee of such property is the person performing the services in connection with the transfer of said property.


  
 1 








 The undersigned understands that the foregoing election may not be revoked except with the
consent of the Commissioner. 
  

					
	Dated:                     ,         				
			
					  

	The undersigned spouse of taxpayer joins in this election.				                    ,Taxpayer
			
	Dated:                     ,         				
					Spouse of Taxpayer


  
 2 








 EXHIBIT B 

INVESTMENT REPRESENTATION STATEMENT 
  

			
	PURCHASER:		«NAME»
	COMPANY:		PRONAI THERAPEUTICS, INC.
	SECURITY:		COMMON STOCK
	AMOUNT		:
	DATE		:

 In connection with the purchase of the above-listed Securities, the undersigned Purchaser represents to the
Company the following: 
 (a) Purchaser is aware of the Company’s business affairs and financial condition and has acquired
sufficient information about the Company to reach an informed and knowledgeable decision to acquire the Securities. Purchaser is acquiring these Securities for investment for Purchaser’s own account only and not with a view to, or for resale in
connection with, any “distribution” thereof within the meaning of the Securities Act of 1933, as amended (the “Securities Act”). 

(b) Purchaser acknowledges and understands that the Securities constitute “restricted securities” under the Securities Act
and have not been registered under the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Purchaser’s investment intent as expressed herein. In this
connection, Purchaser understands that, in the view of the Securities and Exchange Commission, the statutory basis for such exemption may be unavailable if Purchaser’s representation was predicated solely upon a present intention to hold these
Securities for the minimum capital gains period specified under tax statutes, for a deferred sale, for or until an increase or decrease in the market price of the Securities, or for a period of one (1) year or any other fixed period in the
future. Purchaser further understands that the Securities must be held indefinitely unless they are subsequently registered under the Securities Act or an exemption from such registration is available. Purchaser further acknowledges and understands
that the Company is under no obligation to register the Securities. Purchaser understands that the certificate evidencing the Securities will be imprinted with a legend which prohibits the transfer of the Securities unless they are registered or
such registration is not required in the opinion of counsel satisfactory to the Company. Purchaser understands that the certificate evidencing the Securities will be imprinted with any legend required under applicable state securities laws. 

(c) Purchaser is familiar with the provisions of Rule 701 and Rule 144, each promulgated under the Securities Act, which, in substance,
permit limited public resale of “restricted securities” acquired, directly or indirectly from the issuer thereof, in a non-public offering subject to the satisfaction of certain conditions. Rule 701 provides that if the issuer qualifies
under Rule 701 at the time of the grant of the Stock Purchase Right to Purchaser, the 

  
 1 








 
exercise will be exempt from registration under the Securities Act. In the event the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the Securities Exchange
Act of 1934, ninety (90) days thereafter (or such longer period as any market stand-off agreement may require) the Securities exempt under Rule 701 may be resold, subject to the satisfaction of certain of the conditions specified by Rule 144,
including: (1) the resale being made through a broker in an unsolicited “broker’s transaction” or in transactions directly with a market maker (as said term is defined under the Securities Exchange Act of 1934); and, in the case
of an affiliate, (2) the availability of certain public information about the Company, (3) the amount of Securities being sold during any three (3) month period not exceeding the limitations specified in Rule 144(e), and (4) the
timely filing of a Form 144, if applicable. 
 (d) In the event that the Company does not qualify under Rule 701 at the time of grant
of the Stock Purchase Right, then the Securities may be resold in certain limited circumstances subject to the provisions of Rule 144, which requires the resale to occur not less than one (1) year after the later of the date the Securities were
sold by the Company or the date the Securities were sold by an affiliate of the Company, within the meaning of Rule 144; and, in the case of acquisition of the Securities by an affiliate, or by a non-affiliate who subsequently holds the Securities
less than two (2) years, the satisfaction of the conditions set forth in sections (1), (2), (3) and (4) of the paragraph immediately above. 

(e) Purchaser further understands that in the event all of the applicable requirements of Rule 701 or 144 are not satisfied,
registration under the Securities Act, compliance with Regulation A, or some other registration exemption will be required; and that, notwithstanding the fact that Rules 144 and 701 are not exclusive, the Staff of the Securities and Exchange
Commission has expressed its opinion that persons proposing to sell private placement securities other than in a registered offering and otherwise than pursuant to Rules 144 or 701 will have a substantial burden of proof in establishing that an
exemption from registration is available for such offers or sales, and that such persons and their respective brokers who participate in such transactions do so at their own risk. Purchaser understands that no assurances can be given that any such
other registration exemption will be available in such event. 
  

			
	Signature of Purchaser
	
	PURCHASER:
	
	  

		
	Date:		  




  
 2