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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549


Form 10-Q

|    |  |                                                                                         
|--- |  | ----------------------------------------------------------------------------------------
|[X] |  | Quarterly report pursuant to Section 13 or 15 (d) of the Securities Exchange Act of 1934

For the quarterly period ended June 30, 2003

or

|     |  |                                                                                          
|---- |  | -----------------------------------------------------------------------------------------
|[  ] |  | Transition report pursuant to Section 13 or 15 (d) of the Securities Exchange Act of 1934

For the transition period
from               to

Commission File Number 0-29993

INTRABIOTICS PHARMACEUTICALS, INC.

(Exact name of Registrant as specified in its charter)


|                                                                        |  |                                                   
|----------------------------------------------------------------------- |  | --------------------------------------------------
|DELAWARE
(State or other jurisdiction of incorporation or
organization) |  | 94-3200380
(I.R.S. Employer Identification Number)

2483 East Bayshore Road, Suite 100
Palo Alto, CA 94303

(Address of principal executive offices)

(650) 526-6800

(Registrants telephone number including area code)

Indicate by check mark whether the Registrant: (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
Registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. Yes [X]    No [  ]

Indicate by checkmark whether registrant is an accelerated filer (as defined in
Rule 12b-2 of Securities Exchange Act of 1934).
Yes [  ]    No [X]

There were 3,282,768 shares of the Companys Common Stock, par value $.001,
outstanding as of July 31, 2003.





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TABLE OF CONTENTS



|                              |                                                                                               |                                         |  |  |  |  |  | 
|----------------------------- | --------------------------------------------------------------------------------------------- | --------------------------------------- |  |  |  |  |  | 
|PART I. FINANCIAL INFORMATION
|                              | ITEM I. CONDENSED FINANCIAL STATEMENTS                                                       
|                              |                                                                                               | CONDENSED BALANCE SHEETS               
|                              |                                                                                               | CONDENSED STATEMENTS OF OPERATIONS     
|                              |                                                                                               | CONDENSED STATEMENTS OF CASH FLOWS     
|                              |                                                                                               | NOTES TO CONDENSED FINANCIAL STATEMENTS
|                              | ITEM 2. MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|                              | ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK                            
|                              | ITEM 4. CONTROLS AND PROCEDURES                                                              
|PART II. OTHER INFORMATION   
|                              | ITEM 2. CHANGES IN SECURITIES AND USE OF PROCEEDS                                            
|                              | ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS                                  
|                              | ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K                                                     
|SIGNATURES                   
|EXHIBIT INDEX                
|EXHIBIT 31.1                 
|EXHIBIT 31.2                 
|EXHIBIT 32.1                 



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INTRABIOTICS PHARMACEUTICALS, INC.

FORM 10-Q
QUARTER ENDED June 30, 2003

TABLE OF CONTENTS

|           |  |                                                                                       |  |                                                                                                      |    |  |   |  | 
|---------- |  | ------------------------------------------------------------------------------------- |  | ---------------------------------------------------------------------------------------------------- | -- |  | - |  | 
|PART I.    |  | FINANCIAL INFORMATION                                                                 |  |                                                                                                      |    | 
|Item 1.    |  | Condensed Financial Statements (unaudited)                                            |  |                                                                                                      |    | 
|           |  |                                                                                       |  | Condensed Balance Sheets as of June 30, 2003 and December 31, 2002                                   |    |  | 3 | 
|           |  |                                                                                       |  | Condensed Statements of Operations for the Three- and Six-Month Periods Ended
June 30, 2003 and 2002 |    |  | 4 | 
|           |  |                                                                                       |  | Condensed Statements of Cash Flows for the Six-Month Periods Ended June 30, 2003
and 2002            |    |  | 5 | 
|           |  |                                                                                       |  | Notes to Condensed Financial Statements                                                              |    |  | 6 | 
|Item 2.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations |  |                                                                                                      | 10 | 
|Item 3.    |  | Quantitative and Qualitative Disclosure About Market Risk                             |  |                                                                                                      | 22 | 
|Item 4.    |  | Controls and Procedures                                                               |  |                                                                                                      | 22 | 
|PART II.   |  | OTHER INFORMATION                                                                     |  |                                                                                                      |    | 
|Item 2.    |  | Changes in Securities and Use of Proceeds                                             |  |                                                                                                      | 23 | 
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                   |  |                                                                                                      | 23 | 
|Item 6.    |  | Exhibits and Reports on Form 8-K                                                      |  |                                                                                                      | 24 | 
|SIGNATURES |  |                                                                                       |  | 25                                                                                                   |   

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PART I. FINANCIAL INFORMATION




ITEM I. CONDENSED FINANCIAL STATEMENTS




INTRABIOTICS PHARMACEUTICALS, INC.
CONDENSED BALANCE SHEETS
(IN THOUSANDS)

|                                     |                               |                                            |          |             |        |              |          |        |        | 
|------------------------------------ | ----------------------------- | ------------------------------------------ | -------- | ----------- | ------ | ------------ | -------- | ------ | ------ | 
|                                     |                               |                                            |          | JUNE 30,    |        | DECEMBER 31,
|                                     |                               |                                            |          | 2003        |        | 2002        
|                                     |                               |                                            |          |             |        |             
|                                     |                               |                                            |          | (Unaudited) |        | (Note 1)    
|Assets                               |                               |                                            |          |             |        |              |          |       
|Current assets:                      |                               |                                            |          |             |        |              |          |       
|                                     | Cash and cash equivalents     |                                            | $        | 11,495      |        |              | $        | 10,170 |       
|                                     | Restricted cash               |                                            |          | 250         |        |              |          | 250    |       
|                                     | Short-term investments        |                                            |          | 196         |        |              |          | 2,895  |       
|                                     | Prepaid drug substance        |                                            |          | 2,375       |        |              |          | 2,375  |       
|                                     | Prepaid expenses              |                                            |          | 630         |        |              |          | 247    |       
|                                     |                               |                                            |          |             |        |              |          |        |       
|                                     |                               | Total current assets                       |          |             | 14,946 |              |          |        | 15,937 | 
|Property and equipment, net          |                               |                                            | 60       |             |        |              | 112      |       
|Other assets                         |                               |                                            | 184      |             |        |              | 177      |       
|                                     |                               |                                            |          |             |        |              |          |        |       
|                                     |                               | Total assets                               |          | $           | 15,190 |              |          | $      | 16,226 | 
|                                     |                               |                                            |          |             |        |              |          |        |       
|Liabilities and Stockholders Equity |                               |                                            |          |             |        |              |          |       
|Current liabilities:                 |                               |                                            |          |             |        |              |          |       
|                                     | Accounts payable              |                                            | $        | 238         |        |              | $        | 345    |       
|                                     | Accrued clinical liabilities  |                                            |          | 57          |        |              |          |       |       
|                                     | Accrued employee liabilities  |                                            |          | 155         |        |              |          | 135    |       
|                                     | Accrued restructuring charges |                                            |          |            |        |              |          | 64     |       
|                                     | Other accrued liabilities     |                                            |          | 212         |        |              |          | 202    |       
|                                     |                               |                                            |          |             |        |              |          |        |       
|                                     |                               | Total current liabilities                  |          |             | 662    |              |          |        | 746    | 
|                                     |                               |                                            |          |             |        |              |          |        |       
|Stockholders equity                 |                               |                                            |          |             |        |              |          |       
|Preferred stock                      |                               |                                            | 1,886    |             |        |              |         |       
|Common stock                         |                               |                                            | 3        |             |        |              | 3        |       
|Additional paid-in capital           |                               |                                            | 218,825  |             |        |              | 216,466  |       
|Deferred stock compensation          |                               |                                            | (195     | )           |        |              | (720     | )     
|Accumulated deficit                  |                               |                                            | (205,991 | )           |        |              | (200,269 | )     
|                                     |                               |                                            |          |             |        |              |          |        |       
|                                     |                               | Total stockholders equity                 |          |             | 14,528 |              |          |        | 15,480 | 
|                                     |                               |                                            |          |             |        |              |          |        |       
|                                     |                               | Total liabilities and stockholders equity |          | $           | 15,190 |              |          | $      | 16,226 | 
|                                     |                               |                                            |          |             |        |              |          |        |       

See accompanying notes.

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INTRABIOTICS PHARMACEUTICALS, INC.
CONDENSED STATEMENTS OF OPERATIONS
(IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)

(UNAUDITED)

|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |         |  
|--------------------------------------------------------------------------------------------- | --------------------------------------------------------- | ------------------------------- | ------------------------------------------ | ------ | ------------------ | ------ | ---------------- | - | ----- | ------ | ------ | ------ | ----- | ------ | ------- | - | ------ | ------- | -
|                                                                                              |                                                           |                                 |                                            |        | THREE MONTHS ENDED |        | SIX MONTHS ENDED
|                                                                                              |                                                           |                                 |                                            |        | JUNE 30,           |        | JUNE 30,        
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                 
|                                                                                              |                                                           |                                 |                                            |        | 2003               |        | 2002             |   | 2003  |        | 2002  
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |       
|Operating expenses:                                                                           |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |  
|                                                                                              |                                                           | Research and development        |                                            | $      | 1,352              |        |                  | $ | 6,411 |        |        | $      | 1,620 |        |         | $ | 13,452 |        
|                                                                                              |                                                           | General and administrative      |                                            |        | 1,043              |        |                  |   | 2,447 |        |        |        | 2,708 |        |         |   | 3,907  |        
|                                                                                              |                                                           | Arbitration settlement          |                                            |        |                   |        |                  |   |      |        |        |        |      |        |         |   | (3,600 | )      
|                                                                                              |                                                           | Restructuring and other charges |                                            |        |                   |        |                  |   |      |        |        |        |      |        |         |   | 91     |        
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|                                                                                              |                                                           |                                 | Total operating expenses                   |        |                    | 2,395  |                  |   |       | 8,858  |        |        |       | 4,328  |         |   |        | 13,850  |  
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|                                                                                              |                                                           |                                 | Operating loss                             |        |                    | (2,395 | )                |   |       | (8,858 | )      |        |       | (4,328 | )       |   |        | (13,850 | )
|                                                                                              |                                                           |                                 | Interest income                            |        |                    | 45     |                  |   |       | 215    |        |        |       | 71     |         |   |        | 480     |  
|                                                                                              |                                                           |                                 | Interest expense                           |        |                    |       |                  |   |       | (113   | )      |        |       |       |         |   |        | (266    | )
|                                                                                              |                                                           |                                 | Other income                               |        |                    |       |                  |   |       | 784    |        |        |       |       |         |   |        | 784     |  
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|Net loss                                                                                      |                                                           |                                 | (2,350                                     | )      |                    |        | (7,972           | ) |       |        | (4,257 | )      |       |        | (12,852 | )
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|                                                                                              | Non-cash deemed dividend related to
beneficial conversion
|                                                                                              |                                                           |                                 | feature of Series A
preferred stock        | (1,418 | )                  |        |                  |  |       |        |        | (1,418 | )     |        |         |  |       
|                                                                                              | Dividends on Series A preferred stock                     |                                 |                                            | (47    | )                  |        |                  |  |       |        |        | (47    | )     |        |         |  |       
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|                                                                                              |                                                           |                                 | Net loss applicable to common stockholders |        | $                  | (3,815 | )                |   | $     | (7,972 | )      |        | $     | (5,722 | )       |   | $      | (12,852 | )
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|Basic and diluted net loss per share applicable
to common stockholders                        |                                                           | $                               | (1.17                                      | )      |                    | $      | (2.58            | ) |       | $      | (1.75  | )      |       | $      | (4.31   | )
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        
|Shares used to compute basic and diluted net
loss per share applicable to common
stockholders |                                                           |                                 | 3,270                                      |        |                    |        | 3,095            |   |       |        | 3,269  |        |       |        | 2,955   |  
|                                                                                              |                                                           |                                 |                                            |        |                    |        |                  |   |       |        |        |        |       |        |         |   |        |        

See accompanying notes.

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INTRABIOTICS PHARMACEUTICALS, INC.
CONDENSED STATEMENTS OF CASH FLOWS
(IN THOUSANDS)
(UNAUDITED)

|                                                                            |                                                                            |                               |        |                           |      |      |         |        |        |  
|--------------------------------------------------------------------------- | -------------------------------------------------------------------------- | ----------------------------- | ------ | ------------------------- | ---- | ---- | ------- | ------ | ------ | -
|                                                                            |                                                                            |                               |        | SIX MONTHS ENDED JUNE 30,
|                                                                            |                                                                            |                               |        |                          
|                                                                            |                                                                            |                               |        | 2003                      |      | 2002
|                                                                            |                                                                            |                               |        |                           |      |     
|Operating activities                                                        |                                                                            |                               |        |                           |      |      |         |       
|Net loss                                                                    |                                                                            | $                             | (4,257 | )                         |      | $    | (12,852 | )     
|Adjustments to reconcile net loss to net cash used in operating activities: |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Amortization of deferred stock compensation                                |                               |        | 95                        |      |      |         | 687    |       
|                                                                            | Depreciation and amortization                                              |                               |        | 52                        |      |      |         | 390    |       
|                                                                            | Acquired workforce amortization                                            |                               |        |                          |      |      |         | 93     |       
|                                                                            | Stock compensation expense                                                 |                               |        | 44                        |      |      |         | 604    |       
|                                                                            | Gain on sale of pre-clinical programs                                      |                               |        |                          |      |      |         | (775   | )     
|                                                                            | Change in assets and liabilities:                                          |                               |        |                           |      |      |         |        |       
|                                                                            |                                                                            | Prepaid expenses              |        |                           | (383 | )    |         |        | 993    |  
|                                                                            |                                                                            | Other assets                  |        |                           | (7   | )    |         |        | (1     | )
|                                                                            |                                                                            | Accounts payable              |        |                           | (107 | )    |         |        | (299   | )
|                                                                            |                                                                            | Accrued clinical liabilities  |        |                           | 57   |      |         |        | 1,811  |  
|                                                                            |                                                                            | Accrued employee liabilities  |        |                           | 20   |      |         |        | (335   | )
|                                                                            |                                                                            | Accrued restructuring charges |        |                           | (64  | )    |         |        | (1,507 | )
|                                                                            |                                                                            | Deferred rent                 |        |                           |     |      |         |        | 144    |  
|                                                                            |                                                                            | Other accrued liabilities     |        |                           | (37  | )    |         |        | (329   | )
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Net cash used in operating activities                                       |                                                                            |                               | (4,587 | )                         |      |      | (11,376 | )     
|Investing activities                                                        |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Proceeds from sale of pre-clinical programs                                |                               |        |                          |      |      |         | 400    |       
|                                                                            | Maturities of short-term investments                                       |                               |        | 2,699                     |      |      |         |       |       
|                                                                            | Cash received in acquisition of subsidiary                                 |                               |        |                          |      |      |         | 58     |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Net cash provided by investing activities                                   |                                                                            |                               | 2,699  |                           |      |      | 458     |       
|Financing activities                                                        |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Proceeds from issuance of common stock, net                                |                               |        | 1                         |      |      |         | 19,438 |       
|                                                                            | Proceeds from issuance of Series A preferred stock and warrants, net       |                               |        | 3,212                     |      |      |         |       |       
|                                                                            | Payments on financing obligations                                          |                               |        |                          |      |      |         | (937   | )     
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Net cash provided by financing activities                                   |                                                                            |                               | 3,213  |                           |      |      | 18,501  |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Net increase in cash and cash equivalents                                   |                                                                            |                               | 1,325  |                           |      |      | 7,583   |       
|Cash and cash equivalents at beginning of period                            |                                                                            |                               | 10,170 |                           |      |      | 27,982  |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Cash and cash equivalents at end of period                                  |                                                                            | $                             | 11,495 |                           |      | $    | 35,565  |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Supplemental disclosure of cash flow information:                           |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Interest paid                                                              |                               | $      |                          |      |      | $       | 266    |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Supplemental disclosure of non-cash information:                            |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Net deferred stock compensation (cancelations due to employee termination) |                               | $      | (430                      | )    |      | $       | (518   | )     
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Other assets received from sale of pre-clinical programs                   |                               | $      |                          |      |      | $       | 375    |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Beneficial conversion feature on Series A preferred stock                  |                               | $      | (1,418                    | )    |      | $       |       |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Accrual for issuance of common stock dividend on Series A preferred stock  |                               | $      | (47                       | )    |      | $       |       |       
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|Cash flow for acquisition of subsidiary:                                    |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Acquired workforce                                                         |                               | $      |                          |      |      | $       | 1,676  |       
|                                                                            | Other current assets acquired                                              |                               |        |                          |      |      |         | 297    |       
|                                                                            | Property and equipment acquired                                            |                               |        |                          |      |      |         | 56     |       
|                                                                            | Liabilities assumed                                                        |                               |        |                          |      |      |         | (75    | )     
|                                                                            | Acquisition costs incurred                                                 |                               |        |                          |      |      |         | (88    | )     
|                                                                            | Common stock issued                                                        |                               |        |                          |      |      |         | (1,924 | )     
|                                                                            |                                                                            |                               |        |                           |      |      |         |       
|                                                                            | Cash received in acquisition                                               |                               | $      |                          |      |      | $       | (58    | )     
|                                                                            |                                                                            |                               |        |                           |      |      |         |       

See accompanying notes.

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INTRABIOTICS PHARMACEUTICALS, INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
(Unaudited)

Note 1. Basis of Presentation and Summary of Significant Accounting Policies

The accompanying condensed financial statements are unaudited and have
been prepared by IntraBiotics Pharmaceuticals, Inc. (the Company) in
accordance with the rules and regulations of the Securities and Exchange
Commission for interim financial information, and in accordance with the
instructions to Form 10-Q and Article 10 of Regulation S-X.

Certain information and footnote disclosures normally included in the
Companys annual audited financial statements (as required by accounting
principles generally accepted in the United States) have been condensed or
omitted. The interim condensed financial statements, in the opinion of
management, reflect all adjustments (consisting of normal recurring
adjustments) necessary for a fair presentation of the Companys financial
position as of June 30, 2003, the results of its operations for the three- and
six-month periods ended June 30, 2003 and 2002 and cash flows for the six-month
periods ended June 30, 2003 and 2002.

The results of operations of the interim periods are not necessarily
indicative of the results of operations to be expected for the fiscal year.
These interim condensed financial statements should be read in conjunction with the
audited financial statements for the year ended December 31, 2002, which are
contained in the Companys Annual Report on Form 10-K, as amended, and filed
with the Securities and Exchange Commission. The condensed balance sheet as of December
31, 2002 is derived from such audited financial statements.

Use of estimates

The preparation of financial statements in conformity with generally
accepted accounting principles in the United States requires management to make
estimates and assumptions that affect the amounts reported in the financial
statements and accompanying notes. Actual results could differ from those
estimates.

Recent Accounting Pronouncements

In August 2002, the Financial Accounting Standards Board issued Statement
No. 146 (SFAS No. 146), Accounting for Costs Associated with Exit or
Disposal Activities.SFAS No. 146 supersedes Emerging Issues Task Force Issue
No. 94-3, Liability Recognition for Certain Employee Termination Benefits and
Other Costs To Exit an Activity (Including Certain Costs Associated with a
Restructuring)and requires that a liability for a cost associated with an
exit or disposal activity be recognized when the liability is incurred, as
opposed to when management is committed to an exit plan. SFAS No. 146 also
establishes that the liability should initially be measured and recorded at
fair value. This Statement is effective for exit or disposal activities
initiated after December 31, 2002. The provisions of SFAS No. 146 are required
to be applied prospectively after the adoption date to newly initiated exit
activities, and may affect the timing of recognizing future restructuring
costs, as well as the amounts recognized. The adoption of the statement on
January 1, 2003 did not have a material impact on the Companys financial
position, results of operations or disclosure.

In November 2002, the FASB issued Interpretation No. 45 (FIN 45),
Guarantors Accounting and Disclosure Requirements for Guarantees, Including
Indirect Guarantees of Indebtedness of Others.FIN 45 requires that a
liability be recorded in the guarantors balance sheet upon issuance of a
guarantee. In addition, FIN 45 requires disclosures about the guarantees that
an entity has issued. FIN 45 is effective on a prospective basis to guarantees
issued or modified after December 31, 2002. The disclosure requirements of FIN
45 are effective for financial statements for interim and annual periods ending
after December 31, 2002. The adoption of FIN 45 did not have any impact on the
Companys financial position, results of operations or disclosure.

In December 2002, the FASB issued SFAS No. 148, Accounting for
Stock-Based Compensation, Transition and Disclosure.SFAS No. 148 provides
alternative methods of transition for a voluntary change to the fair value
based method of accounting for stock-based employee compensation. SFAS No. 148
also requires that disclosures of the pro forma effect of using the fair value
method of accounting for stock-based employee compensation be displayed more
prominently and in a tabular format. Additionally, SFAS No. 148 requires
disclosure of the pro forma effect in interim financial statements. The
transition and annual disclosure requirements of SFAS No. 148 became effective
in the Companys fiscal year 2002. The Company has elected to follow the
intrinsic value method of accounting as prescribed by Accounting Principles
Board Opinion No. 25 (APB 25), Accounting for Stock Issued to Employees to
account for employee and director stock options. See Stock-Based
Compensation (Note 2) for disclosures required by SFAS No. 148.

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In January 2003, the FASB issued FASB Interpretation No. 46 (FIN 46),
Consolidation of Variable Interest Entities, an Interpretation of ARB No. 51.
FIN 46 requires certain variable interest entities to be consolidated by the
primary beneficiary of the entity if the equity investors in the entity do not
have the characteristics of a controlling financial interest or do not have
sufficient equity at risk for the entity to finance its activities without
additional subordinated financial support from other parties. FIN 46 is
effective for all new variable interest entities created or acquired after
January 31, 2003. For variable interest entities created or acquired prior to
February 1, 2003, the provisions of FIN 46 must be applied for the first
interim or annual period beginning after June 15, 2003. The adoption of FIN 46
did not have any effect on the Companys financial position, results of
operations or disclosure.

In May 2003, the FASB issued SFAS No. 150, Accounting for Certain
Financial Instruments with Characteristics of both Liabilities and Equity.
SFAS No. 150 requires that certain financial instruments, which under previous
guidance were accounted for as equity, must now be accounted for as
liabilities. The financial instruments affected include stock with mandatory
redemption, certain financial instruments that require or may require the
issuer to buy back some of its shares in exchange for cash or other assets and
certain obligations that can be settled with shares of stock. SFAS No. 150 is
effective for all financial instruments entered into or modified after May 31,
2003 and must be applied to the Companys existing financial instruments
effective July 1, 2003, the beginning of the first fiscal period after June 15,
2003. The Company does not expect the adoption of SFAS No. 150 to have a
material effect on its financial position, results of operations or disclosure.

Note 2. Stock-Based Compensation

As permitted by Statement of Financial Accounting Standards No. 123 (SFAS
123), Accounting for Stock-Based Compensation, as amended by Statement of
Financial Standards No. 148, Accounting for Stock-Based Compensation -
Transition and Disclosure,the Company has elected to follow APB 25 and
related Interpretations in accounting for stock-based employee compensation.
Under APB 25, if the exercise price of the Companys employee and director
stock options equals or exceeds the fair market value of the underlying stock
on the date of grant, no compensation expense is recognized. When the exercise
price of the employee or director stock options is less than the fair
market value of the underlying stock on the grant date, the Company records deferred
compensation for the difference. Deferred compensation is being amortized on a
straight-line basis over the vesting period of the original award, ranging from
four to six years.

Options or stock awards issued to non-employees are recorded at their fair
value as determined in accordance with SFAS 123, and are recognized over the
related service period and are periodically re-measured as the underlying
options vest.

The following table illustrates the effect on net loss and net loss per
share applicable to common stockholders if the Company had applied the fair value recognition provisions of SFAS
123 to stock-based employee compensation (in thousands, except per share
amounts):

|                                                                                                                |                                 |   |                    |       |                  |   |        |       |      |   |        |       |   |   |         |       |  
|--------------------------------------------------------------------------------------------------------------- | ------------------------------- | - | ------------------ | ----- | ---------------- | - | ------ | ----- | ---- | - | ------ | ----- | - | - | ------- | ----- | -
|                                                                                                                |                                 |   | Three Months Ended |       | Six Months Ended
|                                                                                                                |                                 |   | June 30,           |       | June 30,        
|                                                                                                                |                                 |   |                    |       |                 
|                                                                                                                |                                 |   | 2003               |       | 2002             |   | 2003   |       | 2002
|                                                                                                                |                                 |   |                    |       |                  |   |        |       |     
|Net loss applicable to common stockholders, as reported                                                         |                                 | $ | (3,815             | )     |                  | $ | (7,972 | )     |      | $ | (5,722 | )     |   | $ | (12,852 | )    
|Add: Stock-based employee compensation expense included in
reported net loss                                    |                                 |   | 57                 |       |                  |   | 199    |       |      |   | 119    |       |   |   | 687     |      
|Deduct: Total stock-based employee compensation expense
determined under fair value based method for all awards |                                 |   | (387               | )     |                  |   | (620   | )     |      |   | (810   | )     |   |   | (1,079  | )    
|                                                                                                                |                                 |   |                    |       |                  |   |        |       |      |   |        |       |   |   |         |      
|Pro forma net loss applicable to common stockholders                                                            |                                 | $ | (4,145             | )     |                  | $ | (8,393 | )     |      | $ | (6,413 | )     |   | $ | (13,244 | )    
|                                                                                                                |                                 |   |                    |       |                  |   |        |       |      |   |        |       |   |   |         |      
|Net loss per share applicable to common stockholders:                                                           |                                 |   |                    |       |                  |   |        |       |      |   |        |       |   |   |         |      
|                                                                                                                | Basic and diluted  as reported |   | $                  | (1.17 | )                |   | $      | (2.58 | )    |   | $      | (1.75 | ) |   | $       | (4.31 | )
|                                                                                                                |                                 |   |                    |       |                  |   |        |       |      |   |        |       |   |   |         |      
|                                                                                                                | Basic and diluted  pro forma   |   | $                  | (1.27 | )                |   | $      | (2.71 | )    |   | $      | (1.96 | ) |   | $       | (4.43 | )
|                                                                                                                |                                 |   |                    |       |                  |   |        |       |      |   |        |       |   |   |         |      

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The fair value for the Companys options was estimated at the date of the grant
using the Black-Scholes option pricing model for the three- and six-month
periods ended June 30, 2003 and 2002 with the following weighted-average
assumptions:

|                         |  |                    |      |                  |  |         |      |         |  |  |      |   |  |  |      |  
|------------------------ |  | ------------------ | ---- | ---------------- |  | ------- | ---- | ------- |  |  | ---- | - |  |  | ---- | -
|                         |  | Three Months Ended |      | Six Months Ended
|                         |  | June 30,           |      | June 30,        
|                         |  |                    |      |                 
|                         |  | 2003               |      | 2002             |  | 2003    |      | 2002   
|                         |  |                    |      |                  |  |         |      |        
|Risk-free interest rates |  |                    | 2.32 | %                |  |         | 4.44 | %       |  |  | 2.62 | % |  |  | 4.45 | %
|Volatility               |  |                    | 1.00 |                  |  |         | 1.00 |         |  |  | 1.00 |   |  |  | 1.00 |  
|Dividend yield           |  |                    |     |                  |  |         |     |         |  |  |     |   |  |  |     |  
|Expected life of option  |  | 5 years            |      | 5 years          |  | 5 years |      | 5 years

Note 3. Comprehensive Loss

Comprehensive loss is solely comprised of the net loss in each period
presented.

Note 4. Contractual Commitments

In February 2003, the Company entered into an operating lease agreement
for a facility in Palo Alto, California, which expires in June 2004. Under the
terms of the lease, the Company is committed to pay an aggregate of
approximately $84,000 in 2003 and $43,000 in 2004.

Note 5. Stock Options Cancellation and Regrant

In February 2003, the Board of Directors approved a cancellation and
re-grant of 321,335 unexercised stock options held by the existing employees
and directors of the Company. Upon election by the participants, the
unexercised stock options were all cancelled and new stock options were granted
in a one-for-one exchange. The re-granted options have an exercise price equal
to the closing price of the Companys common stock on the Nasdaq National
Market as of February 5, 2003, or $2.76 per share, post-split (see Note 8). The
options vest over a four-year period and will expire in February 2008 if not
exercised. Variable accounting is being applied to the re-granted options,
starting from the date of re-grant, and the related compensation expense may
have a significant impact on the Companys future results of operations.
Compensation expense recorded for these options during both the three- and
six-month periods ended June 30, 2003 was $24,000.

Note 6. Net Loss Per Share

Basic and diluted net loss per share applicable to common stockholders is
presented in accordance with Financial Accounting Standards Board Statement No.
128, Earnings Per Share,and is calculated using the weighted-average number
of shares of common stock outstanding during the period, less shares subject to
repurchase. Diluted net loss per share applicable to common stockholders
includes the impact of potentially dilutive securities (stock options, warrants
and convertible preferred stock). As the Companys potentially dilutive
securities were anti-dilutive for all periods, they are not included in the
calculations of diluted net loss per share applicable to common stockholders.
The total number of shares excluded from the calculations for stock options,
warrants and convertible preferred stock were 2,724,878 and 402,414
for the three-month periods ended June 30, 2003 and 2002,
respectively, and 2,668,892 and 330,680 for the six-month periods
ended June 30, 2003 and 2002, respectively.

Note 7. Restructuring and Other Charges

In October 2002, the Company announced a restructuring plan as a result of
the failure of its then recently completed phase III clinical trial for the
prevention of oral mucositis in cancer patients. This restructuring plan
reduced headcount by 26 employees in research and development and general and
administrative, or 70% of the Companys workforce. In accordance with
provisions of EITF 94-3 and related interpretations, the Company recorded
restructuring charges of $848,000 for severance costs of which $784,000 were
paid as of December 31, 2002. No other charges were expensed as a result of the
restructuring plan. The remaining severance accrual as of December 31, 2002 of
$64,000 was paid in January 2003 to employees who left the company in December
2002. No other charges were expensed in 2003 as a result of the restructuring
plan.

Note 8. Reverse Stock Split

On April 3, 2003, the Companys stockholders authorized a 1-for-12 reverse
stock split of all outstanding shares of the Companys

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common stock. The Company effected the split on April 10, 2003. All share and
per share amounts have been retroactively adjusted to reflect the stock split for all periods
presented.

Note 9. Stockholders Equity

On May 1, 2003, in a private placement transaction, the Company sold 350
shares of a newly created Series A convertible preferred stock (the Preferred
Stock) of $0.001 par value, and issued warrants to purchase 920,699 shares of
common stock, resulting in net cash proceeds of $3.2 million. The primary
purpose of completing the private placement was to provide funds for the
clinical trial of iseganan HCl for the prevention of ventilator-associated
pneumonia (VAP), as well as for other general corporate purposes and working
capital.

The Preferred Stock is convertible into 1,841,404 shares of common stock
at any time, at a conversion price of $1.90 per share, subject to anti-dilution
adjustments upon the occurrence of certain events, such as stock splits,
payment of dividends to common stockholders, reorganizations, mergers or
consolidations. Each share of Preferred Stock automatically converts into
shares of common stock on the tenth day after the day that the closing sale
price of the Companys common stock on the Nasdaq National Market has reached
at least $8.28 and has remained at such level for 20 consecutive trading days,
but only after the earlier to occur of (1) the unblinding and the public
announcement of the results of the Companys phase II/III clinical trial of
iseganan HCl for the prevention of VAP, or (2) the second anniversary of the
date the Preferred Stock was first issued. The holders of Preferred Stock are
also entitled to receive, but only out of funds legally available for
dividends, cumulative dividends payable quarterly, at the annual rate of eight
percent of the original issue price of $10,000 on each outstanding share of
Preferred Stock. The dividend shall be paid in common stock based on the
average of the closing sales prices of the common stock on the Nasdaq National
Market for the five trading days immediately preceding and ending on the last
trading day prior to the date the dividends are payable. The dividends are
paid in preference to any other declared dividends. Upon any liquidation,
dissolution or winding up (as such terms are defined in the Companys
Certificate of Designation) of the Company, before any distribution or payment
can be made to the holders of the Companys common stock, each holder of
Preferred Stock is entitled to receive an amount equal to $10,000 plus all
accrued or declared and unpaid dividends. Each share of Preferred Stock is
entitled to a number of votes equal to the number of shares of common stock
issuable based upon a conversion price equal to the closing bid price of the
common stock on the Nasdaq National Market on the date the Preferred Stock and
Warrant Purchase Agreement was signed. The number of votes is not adjustable
except upon a stock split, a reverse stock split, or other similar event
affecting the rights of the Preferred Stock. Holders of Preferred Stock are
also entitled to elect two members of the Board of Directors, and a majority of
the holders of the Preferred Stock must consent to certain actions prior to the
Company taking them.

In
connection with the sale of the Preferred Stock, the Company issued
immediately exercisable warrants to purchase 920,699 shares of the Companys
common stock to the purchasers of the Preferred Stock, at an exercise price of $2.07 per share, subject to anti-dilution
adjustments upon the occurrence of certain events, such as stock splits,
payment of dividends to common stockholders, reorganizations, mergers or
consolidations. Additionally, the exercise price of the warrants is reduced by
50% if the Companys common stock is delisted from the Nasdaq National Market.
The warrants will expire in five years, if not exercised. The warrants issued
to the holders of Preferred Stock were assigned a value of $1,326,000, which
decreased the carrying value of the Preferred Stock. The warrants were valued
using the Black-Scholes method with the following assumptions: a risk-free
interest rate of 2.52%; an expiration date of April 30, 2008; volatility of
100% and a dividend yield of 0%. In connection with the issuance of the
Preferred Stock and warrants, the Company recorded $1,418,000 related to the
beneficial conversion feature on the Preferred Stock as a deemed dividend,
which increased the loss applicable to common stockholders in the calculation
of basic and diluted net loss per common share. A beneficial conversion feature
is present because the effective conversion price of the Preferred Stock was
less than the fair value of the common stock on the commitment date. Pursuant
to the terms of the Preferred Stock and Warrant Purchase Agreement, the Company
is subject to certain negative and restrictive covenants, such as limitations
on indebtedness and the issuance of additional equity securities without
specific Board approvals. The Company is currently in compliance with each of
the covenants.

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ITEM 2. MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following Managements Discussion and Analysis of Financial Condition
and Results of Operations contains forward-looking statements, which involve
risks, uncertainties and assumptions. Our actual results could differ
materially from those anticipated in these forward-looking statements as a
result of many factors, including those set forth below under RISKS RELATED TO
OUR BUSINESS. The following discussion should be read in conjunction with the
financial statements and notes included elsewhere herein and in our 2002
audited financial statements and notes thereto included in our 2002 Annual
Report on Form 10-K, as amended. All forward-looking statements included in
this document are based on information available to us on the date of this
document, and except as required by law, we assume no obligation to update any
of the forward-looking statements contained in this report to reflect any
future events or developments.

Overview

IntraBiotics Pharmaceuticals, Inc. is a biopharmaceutical company
currently focused on developing an oral solution of iseganan hydrochloride, or
iseganan HCl, for the prevention of ventilator-associated pneumonia, or VAP.
Iseganan HCl is an antimicrobial drug, or a drug capable of destroying
microorganisms, including bacteria and fungi, that cause disease, and is
effective against many drug-resistant, disease-causing bacteria and fungi. VAP
is a bacterial pneumonia that can develop in patients receiving mechanical
(artificial) ventilation and is the most common infection occurring in
mechanically-ventilated patients.

In 2002, we were primarily developing iseganan HCl for the prevention of
ulcerative oral mucositis, a complication that develops in cancer patients
receiving chemotherapy or radiation that results in painful ulcer-like sores in
the mouth and throat. We were evaluating whether an infectious component of
oral mucositis could be prevented or reduced by this drug candidate. We
concluded two large studies, one in patients receiving radiation therapy to the
head and neck, and a second in patients undergoing aggressive chemotherapy. In
the radiation therapy study, there was no difference between iseganan HCl and
placebo, and in the chemotherapy study, differences in favor of iseganan HCl
were insufficient to achieve statistical significance. Iseganan HCl appears to
be safe when applied to the oral cavity. We are not pursuing further
development of iseganan HCl to prevent oral mucositis, and instead we are now
developing iseganan HCl to prevent VAP.

An original Investigational New Drug Application, or IND, was submitted in
December 1999 to support a phase I/IIa trial of iseganan HCl to evaluate safety
and antimicrobial activity in mechanically-ventilated patients who are at risk
of developing VAP. This study was completed in February 2001. A phase I/IIa
trial attempts to obtain preliminary indicators of safety and efficacy of a
drug candidate in a smaller patient population. The phase I/IIa study
demonstrated that single doses of iseganan HCl reduced the level of bacteria in
the oral cavity by more than 100-fold compared to pre-treatment baseline levels
in patients who required mechanical ventilation, and that administration of
iseganan HCl every four hours progressively reduced the level of bacteria in
the oral cavity.

We have met with members of our Steering Committee and Data Monitoring
Committee, which are comprised of doctors and statisticians who are experienced
in the care of mechanically-ventilated patients and/or the design of clinical
trials. Together, we designed a phase II/III study to test the effectiveness of
iseganan HCl in preventing VAP. A phase II/III study attempts to establish the
safety and efficacy of a drug candidate in an expanded patient population. In
April 2003, we amended our IND to formally submit the phase II/III clinical
study protocol for FDA review and comment, and the requirements for
registration are currently being discussed with the FDA. The aggregate costs incurred for the development of
iseganan HCl for the prevention of VAP during 2000, 2001, 2002 and the first
six months of 2003, were approximately $4.0 million. We cannot be certain that
iseganan HCl oral solution will prove to be safe or effective in the prevention
of VAP, or will receive regulatory approvals.

The Company has in the past ordered and received, and may in the future
receive, significant quantities of iseganan HCl drug substance. The Companys
policy is to record any prepayments of such orders as Prepaid drug substance.
When title to the drug substance is accepted by the Company, the purchase
price, including prepaid amounts, is accounted for as a research and
development expense. As a result, the Company may at times hold a significant
amount of iseganan HCl inventory, with the value of this drug substance not
reflected on the Companys balance sheet.

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At June 30, 2003, the Company held over seven kg of finished iseganan HCl
and a significant amount of partially completed iseganan HCl drug product. Also
at June 30, 2003, the Company has prepaid drug substance of $2.4 million
relating to a previously placed order of an additional seven kg of iseganan HCl
expected to be delivered in the second half of 2003. When title to this seven
kg order is accepted, the Company will record a research and development
expense for this $2.4 million, plus $250,000 for an additional amount payable
upon transfer of title. The Company is currently discussing the release and
acceptance of this order with its manufacturing partner, as one manufacturing
step in the production of the related lot, Lot I, was performed outside of set
specifications.

Since commencing operations in 1994, we have not generated any revenue
from product sales, and we have funded our operations primarily through the
private sale of equity securities, funds received from a terminated
collaboration agreement, the proceeds of equipment financing arrangements and
our initial public offering of common stock in March 2000. On May 1, 2003, in a
private placement transaction, we sold shares of a newly created Series A
convertible preferred stock and warrants to purchase common stock resulting in
aggregate net cash proceeds of $3.2 million. The primary purpose of completing
the private placement was to provide funds for our Phase II/III clinical trial
of iseganan HCl for the prevention of VAP as well as for other general
corporate purposes and working capital. We will need to raise additional
funds in the future to continue our operations.

In February 2003, the Board of Directors approved a cancellation and
re-grant of 321,335 unexercised stock options held by the existing employees
and directors of the Company. Upon election by the participants, the
unexercised stock options were all cancelled and new stock options were granted
in a one-for-one exchange. The re-granted options have an exercise price equal
to the closing price of the Companys common stock on the Nasdaq National
Market as of February 5, 2003, or $2.76 per share, post-split (see Note 8). The
options vest over a four-year period and will expire in February 2008 if not
exercised. Variable accounting is being applied to the re-granted options,
starting from the date of re-grant, and the related compensation expense may
have a significant impact on the Companys future results of operations.
Compensation expense recorded for these options during both the three- and
six-month periods ended June 30, 2003 was $24,000.

On April 3, 2003, the Companys stockholders authorized a 1-for-12 reverse
stock split of all outstanding shares of the Companys common stock. The split
became effective on April 10, 2003. All share and per share
amounts have been retroactively
adjusted to reflect the stock split for all periods presented.

Critical Accounting Policies

There have been no material changes to the Companys critical accounting
policies, which are included and described in our Form 10-K, as amended, for
the year ended December 31, 2002 filed with the Securities and Exchange
Commission.

Results of Operations

Three- and six-month Periods Ended June 30, 2003 and 2002

Research and Development

Research and development expenses in 2003 primarily consist of costs
related to the preparation for a new phase II/III clinical trial of iseganan
HCl for the prevention of VAP, and in 2002 consisted primarily of costs
related to phase III clinical trials of iseganan HCl for the prevention of oral
mucositis. Research and development expenses decreased to $1.4 million in the
three-month period ended June 30, 2003, from $6.4 million for the same period
in 2002, and decreased to $1.6 million in the six-month period ended June 30,
2003, from $13.5 million for the same period in 2002. The decrease reflects the
higher cost of enrolling patients for the phase III oral mucositis trial in
2002, as compared to the cost of preparations for the new phase II/III VAP
trial in 2003. We expect research and development expenses to increase
significantly as patients are enrolled for the new phase II/III VAP trial. Our
research and development headcount has decreased to four at June 30, 2003, from
23 at June 30, 2002, primarily as a result of a reduction in workforce in
October 2002 due to negative results from the oral mucositis trial. We believe
our current staff is sufficient to conduct the planned phase II/III trial for
the prevention of VAP. Research and development costs primarily include
salaries for research and development personnel, clinical trial expenses from
clinical trial service providers, drug substance, consulting expenses,
supplies, administrative and patent-related expenses and allocated facilities
costs. Approximately 83% and 74%, of research and development expenses for the
three-month periods ended June 30, 2003 and 2002, respectively, and 73% and 77%
for the six-month periods ended June 30, 2003 and 2002, respectively, were
related to clinical trial activities performed by the clinical trial service
providers. Included in research and development expenses are non-cash stock
compensation charges of $3,000 and $314,000 for the three-month periods

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ended June 30, 2003 and 2002, respectively, and $3,000 and $595,000 for
the six-month periods ended June 30, 2003 and 2002, respectively. The decrease
between periods is primarily due to the cancellation of options for terminated
employees.

General and Administrative

General and administrative expenses decreased to $1.0 million in the
three-month period ended June 30, 2003, from $2.4 million for the same period
in 2002, and decreased to $2.7 million in the six-month period ended June 30,
2003, from $3.9 million for the same period in 2002. The decreases in general
and administrative expense in both periods are a result of reduced headcount,
decreased outside service costs, decreased facility-related costs such as
depreciation and rent, and an overall decrease in other general operating
expenses. General and administrative costs primarily include salaries for
administrative personnel, outside contractors, legal and accounting fees,
insurance, deferred compensation, facilities, supplies and general
administrative expenses. Included in general and administrative expenses are
non-cash stock compensation charges of $71,000 and $349,000 for the three-month
periods ended June 30, 2003 and 2002, respectively, and $136,000 and $696,000
for the six-month periods ended June 30, 2003 and 2002, respectively. The
decrease between periods is primarily due to the cancellation of options for
terminated employees.

Arbitration Settlement

During the six-month period ended June 30, 2002, we received $3.6 million
from a contract vendor as a result of an arbitration settlement relating to a
drug dispensing error in iseganan HCI oral solution phase III clinical trials.
We had no comparable item for the three- and six-month periods ended June 30,
2003.

Restructuring and Other Charges

There were no expenses recorded for restructuring during the three- and
six-month periods ended June 30, 2003, compared to $0 and $91,000 for the same
periods in 2002, respectively. The decrease in restructuring and other charges
was due to the fact that no new restructuring actions occurred during the first
six-months of 2003 as compared to the same period in 2002.

Interest Income and Expense

Interest income decreased to $45,000 and $71,000 in the three- and
six-month periods ended June 30, 2003, respectively, from $215,000 and $480,000
for the same periods in 2002, respectively. The decrease in interest income
resulted from the decrease in average interest earning investment balances as
well as lower interest rates in 2003 relative to the comparable prior year
periods. Interest expense decreased to zero for the three- and six-month
periods ended June 30, 2003, from $113,000 and $266,000 for the same periods in
2002, respectively. The decrease in interest expense is attributed to the
repayment of our line of credit and bank loan in October 2002.

Other Income

In May 2002, we completed the sale of two pre-clinical anti-infective
programs to Micrologix Biotech Inc., a Canadian company, for cash and 750,000
shares of Series A preferred stock of Micrologix, and recognized other income
of $775,000 in the three-month period ended June 30, 2002. We had no comparable
item for the three- and six-month periods ended June 30, 2003. The Micrologix
Series A preferred shares are redeemable at $1 per share or convertible into
common stock at the election of Micrologix upon the occurrence of certain time
and achievement milestones as follows: (1) shares converted into common stock
with a value of $400,000 upon the four month anniversary of the effective date
of the agreement; (2) shares will convert into common stock with a value of
$100,000 upon commencement of certain toxicology studies; and (3) shares will
convert into common stock with a value of $250,000 upon filing for marketing
approval for certain drugs in certain countries. During the quarter ended
September 30, 2002, $200,000 of other income was recognized in connection with
the redemption of 400,000 shares of Series A preferred stock of Micrologix at
$1 per share, which was triggered by the first milestone set forth above.

Net Loss and Net Loss Applicable to Common Stockholders

For the three- and six-month periods ended June 30, 2003, we incurred net
losses of $2.4 million and $4.3 million, respectively, as compared to net
losses of $8.0 million and $12.9 million for the same periods in 2002, a
decrease of $5.6 million and $8.6 million, respectively. Net losses applicable
to common stockholders were $3.8 million and $5.7 million for the three- and
six-month periods ended June 30, 2003, respectively, and included the impact of
a non-cash deemed dividend related to a beneficial conversion feature on our
Series A preferred stock of $1.4 million and Series A preferred stock dividends
of $47,000. A beneficial conversion feature is

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present because the effective conversion price of the preferred stock was
less than the fair value of the common stock on the commitment date. Preferred
stock dividends represent the accrual of the 8% annual dividends payable
quarterly to the holders of our Series A preferred stock in the form of our
common stock. Net losses applicable to common stockholders were the same as net
losses for the three- and six-month periods ended June 30, 2002.

Liquidity and Capital Resources

Cash, cash equivalents, short-term investments and restricted cash were
$11.9 million as of June 30, 2003, compared to $13.3 million as of December 31,
2002. At June 30, 2003, we had restricted cash deposits of $250,000 in
connection with a standby letter of credit issued to PolyPeptide Laboratories
A/S for a drug substance. We had no debt outstanding as of June 30, 2003. We
invest excess funds in short-term money market funds.

Net cash used in operating activities for the six-month periods ended June
30, 2003 and 2002 was $4.6 million and $11.4 million, respectively. Our cash
used for operating activities in each period consisted primarily of the net
loss for each period, excluding non-cash items consisting primarily of
stock-related compensation expenses, and in 2002, non-cash income of $775,000
related to the gain on the sale of the two pre-clinical programs to Micrologix.

Net cash provided by investing activities for the six-month periods ended
June 30, 2003 and 2002 was $2.7 million and $458,000, respectively. The cash
provided in 2003 related to the maturity of short-term investments, and in 2002
primarily related to the proceeds from the sale of the two pre-clinical
programs to Micrologix.

Net cash provided by financing activities for the six-month periods ended
June 30, 2003 and 2002 was $3.2 million and $18.5 million, respectively. The
cash provided in 2003 related to the private placement transaction in May 2003,
in which the Company sold 350 shares of a newly created Series A convertible
preferred stock and issued warrants to purchase 920,699 shares of common stock,
resulting in net cash proceeds of $3.2 million.

The Preferred Stock is convertible into 1,841,404 shares of common stock
at any time, at a conversion price of $1.90 per share, subject to anti-dilution
adjustments upon the occurrence of certain events, such as stock splits,
payment of dividends to common stockholders, reorganizations, mergers or
consolidations. The shares of Preferred Stock carry with them certain rights
and privileges as set forth in the Companys Certificate of Designation and the
Preferred Stock and Warrant Purchase Agreements governing the sale of the
Preferred Stock and the issuance of the warrants. Each share of Preferred Stock
automatically converts into shares of common stock on the tenth day after the
day that the closing sale price of the Companys common stock on the Nasdaq
National Market has reached at least $8.28 and has remained at such level for
20 consecutive trading days, but only after the earlier to occur of (1) the
unblinding and the public announcement of the results of the Companys phase
II/III clinical trial of iseganan HCl for the prevention of VAP, or (2) the
second anniversary of the date the Preferred Stock was first issued. The
holders of Preferred Stock are also entitled to receive, but only out of funds
legally available for dividends, cumulative dividends payable quarterly, at the
annual rate of eight percent of the original issue price of $10,000 on each
outstanding share of Preferred Stock. The dividend shall be paid in common
stock based on the average of the closing sales prices of the common stock on
the Nasdaq National Market for the five trading days immediately preceding and
ending on the last trading day prior to the date the dividends are payable.
The dividends are paid in preference to any other declared dividends. Upon any
liquidation, dissolution or winding up (as such terms are defined in the
Companys Certificate of Designation) of the Company, before any distribution
or payment can be made to the holders of the Companys common stock, each
holder of Preferred Stock is entitled to receive an amount equal to $10,000
plus all accrued or declared and unpaid dividends. Each share of Preferred
Stock is entitled to a number of votes equal to the number of shares of common
stock issuable based upon a conversion price equal to the closing bid price of
the common stock on the Nasdaq National Market on the date the Preferred Stock
and Warrant Purchase Agreement was signed. The number of votes is not
adjustable except upon a stock split, a reverse stock split, or other similar
event affecting the rights of the Preferred Stock. Holders of Preferred Stock
are also entitled to elect two members of the Board of Directors, and a
majority of the holders of the Preferred Stock must consent to certain actions
prior to the Company taking them.

In
connection with the sale of the Preferred Stock, the Company issued
immediately exercisable warrants to purchase 920,699 shares of the Companys
common stock to the purchasers of the Preferred Stock, at an exercise price of $2.07 per share, subject to anti-dilution
adjustments upon the occurrence of certain events, such as stock splits,
payment of dividends to common stockholders, reorganizations, mergers or
consolidations. Additionally, the exercise price of the warrants is reduced by
50% if the Companys common stock is delisted from the Nasdaq National Market.
The warrants will expire in five years, if not exercised. Pursuant to the
terms of the Preferred Stock and Warrant Purchase Agreement, the Company is
subject to certain negative and restrictive covenants, such as limitations on
indebtedness and the

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issuance of additional equity securities without specific Board approvals. The
Company is currently in compliance with each of the covenants.

Cash provided by financing activities for the six-month period ended June
30, 2002 was primarily from net proceeds of $13.9 million and $5.0 million from
two private placements of common stock, partially offset by $937,000 in
payments on financing obligations to a bank.

The following are future contractual commitments at June 30, 2003, (in
thousands):

|                              |  |                        |     |      |  |      |     |      |  |            |    |  |  |   |    |  |  |   |     | 
|----------------------------- |  | ---------------------- | --- | ---- |  | ---- | --- | ---- |  | ---------- | -- |  |  | - | -- |  |  | - | --- | 
|                              |  | Payments Due by Period
|                              |  |                       
|Contractual Commitments       |  | Total                  |     | 2003 |  | 2004 |     | 2005 |  | Thereafter
|                              |  |                        |     |      |  |      |     |      |  |           
|Drug substance                |  | $                      | 475 |      |  | $    | 275 |      |  | $          | 50 |  |  | $ | 50 |  |  | $ | 100 | 
|Operating leases              |  |                        | 93  |      |  |      | 50  |      |  |            | 43 |  |  |   |   |  |  |   |    | 
|Severance payments            |  |                        | 40  |      |  |      | 40  |      |  |            |   |  |  |   |   |  |  |   |    | 
|Consulting payments           |  |                        | 83  |      |  |      | 83  |      |  |            |   |  |  |   |   |  |  |   |    | 
|                              |  |                        |     |      |  |      |     |      |  |            |    |  |  |   |    |  |  |   |     | 
|Total contractual commitments |  | $                      | 691 |      |  | $    | 448 |      |  | $          | 93 |  |  | $ | 50 |  |  | $ | 100 | 
|                              |  |                        |     |      |  |      |     |      |  |            |    |  |  |   |    |  |  |   |     | 

The $475,000 drug substance commitment represents a commitment to
PolyPeptide Laboratories A/S. In 2003 the commitment represents the payment of
$250,000 upon acceptance of a drug substance and a $25,000 fee for storage of
drug substance. The remaining $200,000 represents storage fees for our drug
substance in future periods.

Operating leases relate to the lease for our facility in Palo Alto,
California, which expires in June 2004. Under the terms of the lease we have
committed to pay a total of $84,000 and $43,000 in 2003 and 2004, respectively.

Severance payments relate to the reduction of general and administrative
staff during the six-month period ended June 30, 2003.

Consulting payments relate to an obligation to pay ongoing consulting
payments to Mr. Ken Kelley, a former officer, through September 30, 2003. The
aggregate payments for the duration of the agreement will total $550,000.

We expect to continue to incur substantial operating losses. We currently
anticipate our capital will be sufficient to fund operations
for the next 12 months, although this is dependent upon the rate of enrollment and other factors impacting the timing
and cost of the Phase II/III trial of iseganan HCl oral solution for the
prevention of VAP. We will need to raise additional funds in the
future to continue our operations.

This forecast is a forward-looking statement that involves risks and
uncertainties, and actual results could vary. Our future capital requirements
will depend on many factors, including:



| |  |  | the timing, delay, cost, extent and results of clinical trials;              
| | - |  | -----------------------------------------------------------------------------
|
| |  |  | future opportunities for raising capital;                                    
|
| |  |  | payments to third parties for manufacturing scale up;                        
|
| |  |  | the costs and timing of regulatory approvals;                                
|
| |  |  | the costs of establishing sales, marketing and distribution capabilities; and
|
| |  |  | the progress of our development activities.                                  

Until we can generate sufficient cash from our operations, which we do not
expect for the foreseeable future, we expect to finance future cash needs
through private and public financings, including equity financings. We cannot
be certain that additional funding will be available when needed or on
favorable terms. If additional funding is not available, we may need to delay
or curtail our development and clinical trial activities to a significant
extent, or we may be forced to cease operations.

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Risks Related to Our Business

Our business faces significant risks. In evaluating our business you
should carefully consider the risks described below. Additional risks that we
do not know of or that we currently believe are immaterial may also impair our
business operations. If any of the events or circumstances described in the
following risks actually occurs, our business, financial condition, or results
of operations could be materially adversely affected and the trading price of
our common stock could decline.

We expect to continue to incur future operating losses and may never achieve
profitability.

We have never generated revenue from product sales, and we have incurred
significant net losses in each year since inception. We incurred net losses
applicable to common stockholders of $34.5 million in 2002 and $5.7 million in
the six-month period ended June 30, 2003. As of June 30, 2003, our accumulated
deficit was approximately $206.0 million. We expect to continue to incur
substantial additional losses for the foreseeable future, and we may never
become profitable. To date, we have financed our operations primarily through
the private sale of equity securities, funds received from a terminated
collaboration agreement, the proceeds of equipment financing arrangements, and
our initial public offering of common stock in March 2000.

In the first quarter of 2003, we commenced preparations for a new phase
II/III trial of iseganan HCl oral solution for the prevention of VAP. We may
also develop iseganan HCl for other indications in the future or acquire or
license other products. We will receive product revenues only if we complete
clinical trials with respect to one or more products, receive regulatory
approvals and successfully commercialize such products. We do not know whether
we will be successful in developing iseganan HCl for our currently planned VAP
indication or other indications, or in acquiring or licensing other products.

We depend on the outcome of our clinical trial for the prevention of VAP and
any future clinical trials for other indications for iseganan HCl or for
products that we may license or acquire, and if they are unsuccessful, we will
not be able to commercialize any products and may be forced to cease
operations.

We had only one late stage lead product, iseganan HCl for the treatment of
ulcerative oral mucositis, which failed in the phase III trial conducted on
patients with head and neck cancer receiving radiotherapy and the phase III
trial conducted on patients with cancer receiving aggressive chemotherapy. Our
other indications for iseganan HCl are in earlier stages of clinical
development. In the first quarter of 2003, we commenced preparations for a new
phase II/III trial of iseganan HCl oral solution for the prevention of VAP, and
we are focusing our resources on this trial. The requirements for
registration are currently being discussed with the FDA. It is
possible that the
final design will call for an enrollment of significantly greater than the 500 patients indicated in the originally submitted study
protocol, followed by a confirmatory Phase III trial of a similar
size. An increase in planned enrollment would increase the cost of the Phase II/III trial
and the time it takes to complete, and we would need to raise additional funds
to complete this trial. If this phase II/III trial fails to meet its primary
endpoint, and we do not acquire or license any additional product candidates,
we may not be able to commercialize any products and we may be forced to cease
operations. In addition, as a result of our focus on the VAP trial and the
delay in clinical development of any other drug candidates, our ability to
generate product revenue will be delayed, and we do not expect to generate
product revenue in the near term.

We must raise capital to continue our operations, and if we fail to obtain the
capital necessary to fund our operations, we will be unable to develop our drug
candidates and may have to cease operations.

For the year ended December 31, 2002 and the six-month period ended June
30, 2003, net cash used for operating activities was $26.3 million and $4.6
million, respectively. At June 30, 2003, our cash and cash equivalents,
including short-term investments, were $11.9 million, which included restricted
cash of $250,000. We currently anticipate this capital will be
sufficient to fund operations for the
next 12 months, although this is dependent upon the rate of enrollment and
other factors impacting the timing and cost of the Phase II/III trial of
iseganan HCl oral solution for the prevention of VAP. We will need to raise
additional funds in the future to continue our operations.

Our future liquidity and capital requirements will depend on many factors,
including the final design, timing, cost, and progress of our current VAP
trial, our evaluation of, and decisions with respect to, our strategic
alternatives, costs associated with the regulatory approvals, securing
in-licensing opportunities, purchasing additional products or drug candidates
and conducting pre-clinical research and clinical development of those drug
candidates.

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We believe that additional financing will be required in the future to
fund our operations, conduct any other possible trials of iseganan HCl, or
commercialize our current and any future product candidates. We do not know
whether additional financing will be available when needed or on acceptable
terms, if at all. If we are unable to raise additional financing when
necessary, we may have to delay our product development efforts or any product
acquisitions or be forced to cease operations.

If we raise additional capital by issuing securities or through collaboration
and licensing arrangements, our existing stockholders may experience dilution
or we may be required to relinquish rights to our technologies or product
candidates.

We may raise additional financing through public or private equity
offerings, debt financings or additional corporate collaboration and licensing
arrangements. To the extent we raise additional capital by issuing equity
securities, our stockholders may experience dilution. To the extent that we
raise additional funds through collaboration and licensing arrangements, it may
be necessary to relinquish some rights to our technologies or product
candidates, or grant licenses on terms that are not favorable to us.

If our contract research organizations assisting in our clinical trials fail to
appropriately manage our clinical trial, the trial could be delayed or could
fail.

We rely on contract research organizations to assist us in managing and
monitoring our clinical trial. We have entered into agreements with Amarex,
LLC, Orion Clinical Services, Ltd., Icon Laboratories, Inc., Patheon Inc.,
Fisher Scientific International Inc. and Advanced Clinical Trials, Inc. to
provide clinical research services. The FDA may inspect some of our clinical
investigational sites, our contract research organizations records and our
facility and files to determine if the clinical trial is conducted according to
good clinical practices. If the FDA determines that the trial is not in
compliance with good clinical practices, we may be required to repeat the
clinical trial. If our contract research organizations fail to perform under
our agreements with them, we may face delays in completing our clinical trial
or failure of our clinical program.

If we fail to obtain FDA approvals for any future products that we develop,
acquire or license, we will be unable to commercialize our drug candidates.

We do not have a drug approved for sale in the U.S. or any foreign market.
We must obtain approval from the FDA in order to sell our drug candidate in the
U.S. and from foreign regulatory authorities in order to sell our drug
candidate in other countries. We must successfully complete pivotal clinical
trials and demonstrate manufacturing capability before we can file with the FDA
for approval to sell our products. The FDA could require us to repeat clinical
trials as part of the regulatory review process. Delays in obtaining or failure
to obtain regulatory approvals may:



| |  |  | delay or prevent the successful commercialization of our drug candidate;
| | - |  | ------------------------------------------------------------------------
|
| |  |  | diminish our competitive advantage; and                                 
|
| |  |  | defer or decrease our receipt of revenues or royalties.                 

The regulatory review and approval process is lengthy, expensive and
uncertain. Extensive pre-clinical and clinical data and supporting information
must be submitted to the FDA for each indication to establish safety and
effectiveness in order to secure FDA approval. A number of new drugs for
certain indications, iseganan HCl for the prevention of oral mucositis
included, have shown promising results in early clinical trials, but
subsequently failed to establish sufficient safety and efficacy data to obtain
necessary regulatory approvals. A number of companies have suffered significant
setbacks in advanced clinical trials, even after promising results in earlier
trials. We have limited experience in obtaining such approvals, and cannot be
certain when, if ever, we will receive these regulatory approvals. If we are
unable to demonstrate the safety and efficacy of our drug candidate, we will be
unable to obtain the required regulatory approvals and we will be unable to
commercialize the drug candidate and generate product revenue.

In addition to initial regulatory approval, our drug candidate will be
subject to extensive and rigorous ongoing domestic and foreign government
regulation. Any approvals, once obtained, may be withdrawn if compliance with
regulatory requirements is not maintained or safety problems are identified.
Failure to comply with these requirements may subject us to stringent
penalties.

Development and commercialization of competitive products could reduce or
prevent sales of any future products that we develop, acquire or license.

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We may be unable to compete successfully if other companies develop and
commercialize competitive products that are less expensive, more effective,
have fewer side effects or are easier to administer than drug candidates which
we develop, acquire or license. If we are unable to compete successfully with
any future drug candidate, physicians may not recommend and patients may not
buy our drug.

We are not aware of any products that compete with iseganan HCl for the
prevention of VAP. However, pharmaceutical companies and biotechnology
companies may develop products in the future that compete with iseganan HCl for
the prevention of VAP. Many of these companies have substantially greater
experience, financial resources and larger research and development staffs than
we do. In addition, many of these companies, either alone or together with
their collaborative partners, have significantly greater experience than we do
in developing drugs, obtaining regulatory approvals and manufacturing and
marketing products. We also compete with these organizations and other
companies for in-licensing opportunities for future drug candidates, and for
attracting scientific and management personnel.

If we are unable to adequately protect our intellectual property, we may be
unable to sell our products or to compete effectively.

We rely on a combination of patents, trade secrets and contractual
provisions to protect our intellectual property. If we fail to adequately
protect our intellectual property, other companies or individuals may prevent
us from selling our products or may develop competing products based on our
technology. Our success depends in part on our ability to:



| |  |  | obtain patents;                                                      
| | - |  | ---------------------------------------------------------------------
|
| |  |  | protect trade secrets;                                               
|
| |  |  | operate without infringing upon the proprietary rights of others; and
|
| |  |  | prevent others from infringing on our proprietary rights.            

We will be able to protect our proprietary rights from unauthorized use by
third parties only to the extent that our proprietary rights are covered by
valid and enforceable patents or are effectively maintained as trade secrets.

We expect to protect our proprietary position by filing U.S. and foreign
patent applications related to our proprietary technology, inventions and
improvements that are important to the development of our business. For
example, we own or have rights to nine patents and six pending patent
applications in the U.S. However, the patent position of biopharmaceutical
companies involves complex legal and factual questions. We cannot predict the
enforceability or scope of any issued patents or those that may issue in the
future. Patents, if issued, may be challenged, invalidated or circumvented.
Consequently, if any patents that we own or license from third parties do not
provide sufficient protection, our competitive position would be weakened.
Furthermore, others may independently develop similar technologies or duplicate
any technology that we have developed. In addition, we may not be issued
patents for our pending patent applications, those we may file in the future or
those we may license from third parties.

In addition to patents, we rely on trade secrets and proprietary know-how.
Our contract manufacturers perform the manufacturing processes covered by these
trade secrets. Accordingly, our contract manufacturers and we must maintain
confidentiality. We have confidentiality and proprietary information agreements
with our contract manufacturers and with our employees. These agreements may
not provide meaningful protection or adequate remedies for our technology in
the event of unauthorized use or disclosure of confidential and proprietary
information.

We may be subject to intellectual property litigation that could be costly and
time-consuming.

The biotechnology and pharmaceutical industries have been characterized by
extensive litigation regarding patents and other intellectual property rights.
Although we are not currently a party to any lawsuits, third parties may assert
infringement or other intellectual property claims against us. We may have to
pay substantial damages, including treble damages for past infringement if it
is ultimately determined that our products infringe a third partys proprietary
rights. The defense and prosecution of intellectual property suits, U.S. Patent
and Trademark Office interference proceedings and related legal and
administrative proceedings in the U.S and internationally are costly and
time-consuming to pursue and their outcome is uncertain. If we become involved
in any of these proceedings, we will incur substantial expense, and the efforts
of our technical and management personnel will be significantly diverted. An
adverse determination may result in the invalidation of our patents, subject us
to significant liabilities or require us to

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seek licenses that may not be available from third parties on satisfactory
terms, or at all. Our stock price could decline because of litigation or
interference proceedings initiated or threatened against us.

If physicians and patients do not accept our products, we may be unable to
generate significant revenue, if any.

Any future drug candidate that we develop, acquire or license may not gain
market acceptance among physicians, patients and the medical community. If any
future drug candidate fails to achieve market acceptance, we may be unable to
successfully market and sell the product, which would limit our ability to
generate revenue. The degree of market acceptance of any drug candidate depends
on a number of factors, including:



| |  |  | demonstration of clinical efficacy and safety;             
| | - |  | -----------------------------------------------------------
|
| |  |  | cost-effectiveness;                                        
|
| |  |  | convenience and ease of administration;                    
|
| |  |  | potential advantage over alternative treatment methods; and
|
| |  |  | marketing and distribution support.                        

Physicians will not recommend our products until such time as clinical
data or other factors demonstrate the safety and efficacy of our drugs as
compared to other treatments. In practice, competitors may be more effective in
marketing their drugs. Even if the clinical safety and efficacy of our product
is established, physicians may elect not to recommend its use. For example,
physicians may be reluctant to prescribe widespread use of our product because
of concern about developing bacterial strains that are resistant to our drugs,
or because of the cost of our drug.

The failure to recruit and retain key personnel may delay our ability to
execute our business plan.

We are highly dependent on our management and technical staff. Competition
for personnel is intense. If we lose the services of any of our senior
management or technical staff, we may be unable to successfully complete our
planned clinical trial for VAP. In particular, the loss of the services of
Henry J. Fuchs, our President and Chief Executive Officer, or Steven Ketchum,
our Vice President, Regulatory Affairs, could significantly impede our research
and development efforts, our relations with potential collaborators and
completion of our planned clinical trial for VAP. We do not have employment
agreements with Mr. Fuchs or Mr. Ketchum. We do not maintain key person life
insurance and do not have employment agreements with our other members of
management and technical staff. In October 2002, we completed a restructuring
that included a reduction in force of approximately 70% of our workforce. Since
then we have further reduced our staff, and as of June 30, 2003, we had nine
full-time employees. In order to pursue any future product development,
marketing and commercialization, we will need to hire additional qualified
scientific personnel to perform research and development and personnel with
expertise in clinical testing, government regulation, manufacturing, marketing
and finance. We may not be able to attract and retain personnel on acceptable
terms given the competition for such personnel among biotechnology,
pharmaceutical and other companies.

In addition, we rely on consultants to assist us in formulating our
research and clinical development strategy. All of these consultants are
employed by other entities. They may have commitments to, or relationships
with, other entities that may limit their availability to us. The loss of the
services of these personnel may delay our research and development efforts.

Directors, executive officers, principal stockholders and affiliated entities
beneficially own approximately 58% of our capital stock and may be able to
exert control over our activities.

As of June 30, 2003, our directors, executive officers, principal
stockholders and affiliated entities beneficially own, in the aggregate,
approximately 58% of our outstanding common stock. These stockholders, if
acting together, will be able to control the outcome of any matter requiring
approval by our stockholders, including the election of directors and the
approval of mergers or other business combination transactions.

Anti-takeover provisions in our charter documents and under Delaware law may
make an acquisition of us more difficult.

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Provisions of our certificate of incorporation and bylaws could make it
more difficult for a third party to acquire us, even if doing so would be
beneficial to our stockholders.

These provisions:



| |  |  | provide for a classified board of directors of which approximately one third of the directors will be elected each year;                          
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------
|
| |  |  | allow the authorized number of directors to be changed only by resolution of the board of directors;                                              
|
| |  |  | require that stockholder actions must be effected at a duly called
stockholder meeting and prohibit stockholder action by written consent;        
|
| |  |  | establish advance notice requirements for nominations to the board of
directors or for proposals that can be acted on at stockholder meetings;
and
|
| |  |  | limit who may call stockholder meetings.                                                                                                          

In addition, because we are incorporated in Delaware, we are governed by
the provisions of Section 203 of the Delaware General Corporation Law, which
may prohibit large stockholders from consummating a merger with, or acquisition
of us. These provisions may prevent a merger or acquisition that would be
attractive to stockholders and could limit the price that investors would be
willing to pay in the future for our common stock.

If we are unable to maintain our Nasdaq National Market listing, the liquidity
of our common stock would be seriously impaired and we would become subject to
various statutory requirements and contractual provisions, which would likely
harm our business.

On November 12, 2002, we received a letter from Nasdaq advising us that
our common stock had not met Nasdaqs minimum bid price requirement for 30
consecutive trading days and that, if we were unable to demonstrate compliance
with this requirement during the 90 calendar days ending on February 10, 2003,
our common stock may be subject to delisting from the Nasdaq National Market.
On March 19, 2003, we received an additional letter from Nasdaq advising us
that our grace period for regaining compliance had been extended in accordance
with Nasdaqs new rules, until May 12, 2003. On April 10, 2003, we effected a
1-for-12 reverse stock split to regain compliance with this listing requirement
and, on May 16, 2003 we received a letter from Nasdaq stating that we had
regained compliance and the matter was closed. However, we cannot assure that
the stock split will be sufficient to maintain our stock price on a sustainable
basis.

The Nasdaq National Market further requires maintenance of a minimum
market value of publicly held shares of $5 million. Publicly held shares are
defined as total shares outstanding less any shares held by officers, directors
or beneficial owners of 10% or more of our outstanding shares of common stock.
We cannot assure that we will be able to comply with these requirements.

The Nasdaq National Market also requires maintenance of minimum
stockholders equity of $10 million. On May 1, 2003, we raised an additional
$3.5 million in equity financing before issuance costs. However, as we expend
capital resources on our clinical trial, it is likely that our stockholders
equity will fall below the $10 million minimum during 2003 if we do not raise
additional funding.

If we are unable to meet the Nasdaq National Market requirements, at the
discretion of Nasdaq, our common stock may be transferred to the Nasdaq
SmallCap Market. Transferring to the Nasdaq SmallCap Market would provide us
with an additional grace period to satisfy the minimum bid price requirement
provided that we meet the Nasdaq SmallCap Markets other listing requirements,
including the maintenance of stockholders equity of at least $5 million. In
such event we would still be required to satisfy various listing maintenance
standards for our common stock to be quoted on the Nasdaq SmallCap Market,
including the minimum bid price requirement after expiration of any grace
periods. If we fail to meet such standards, our common stock would likely be
delisted from the Nasdaq SmallCap Market and it would trade on the
over-the-counter bulletin board, commonly referred to as the pink sheets.
Such alternatives are generally considered as less efficient markets and would
seriously impair the liquidity of our common stock and limit our potential to
raise future capital through the sale of our common stock, which could
materially harm our business.

If we are delisted from the Nasdaq National Market, we will face a variety
of legal and other consequences that will likely negatively affect our business
including, without limitation, the following:

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| |  |  | we may lose our exemption from the provisions of Section 2115 of the
California Corporations Code, which imposes aspects of California
corporate law on certain non-California corporations operating within
California. As a result, (i) our board of directors would no longer be
classified and our stockholders would elect all of our directors at each
annual meeting, (ii) our stockholders would be entitled to cumulative
voting, and (iii) we would be subject to more stringent stockholder
approval requirements and more stockholder-favorable dissenters rights
in connection with certain strategic transactions;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| |  |  | the state securities law exemptions available to us would be more
limited and, as a result, future issuances of our securities may require
time-consuming and costly registration statements and qualifications;                                                                                                                                                                                                                                                                                                                                                                                                                 
|
| |  |  | due to the application of different securities law exemptions and
provisions, we may be required to amend our stock option and stock
purchase plans and comply with time-consuming and costly administrative
procedures;                                                                                                                                                                                                                                                                                                                                                                                                         
|
| |  |  | the exercise price on the warrants issued in conjunction with the issuance of Series A Preferred Stock would be reduced by
50%, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|
| |  |  | we may lose current or potential investors.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

We may become subject to the SECs penny stock rules, which may decrease the
liquidity of our common stock and negatively impact the ability of purchasers
of our common stock to sell our common stock in the secondary market.

SEC rules place restrictions on the ability of brokers or dealers to sell
securities that are defined as penny stocks, which include securities priced
under five dollars, unless an exception to the penny stock rules applies. We
are not currently subject to the penny stock rules because our common stock
currently qualifies for two separate exceptions to the SECs penny stock rules.
The first exception for which we qualify renders the penny stock rules
inapplicable if our securities are traded on Nasdaq. As discussed in the
immediately preceding risk factor, our common stock is currently traded on the
Nasdaq, but we may be delisted from the Nasdaq if we do not continue to meet
the Nasdaqs listing requirements. In addition, the penny stock rules do not
apply to securities of companies that have been in continuous operation for at
least three years and have net tangible assets (total assets less intangible
assets minus liabilities, based on audited financial statements) in excess of
$2.0 million. We have been in continuous operation for more than three years,
and, based on audited financial statements as of December 31, 2002, we had net
tangible assets of approximately $15.5 million. Therefore, our common stock
also qualifies for this exception to the penny stock rules. However, as we
expend capital resources on our clinical trial, our net tangible assets will
continue to decrease and we may not be able to continue to qualify for this
exemption, unless we raise additional funding.

If we were to become subject to the SECs penny stock rules, brokers or
dealers would generally be required to provide a purchaser of our common stock
with a disclosure document stating, among other things:



| |  |  | that penny stocks are risky and informing the customer of his or her
right to pricing information relating to our common stock and to
information regarding the compensation to be received by the salesperson
and the brokerage firm for effecting a trade in our common stock;                                              
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| |  |  | that the broker must send its customer a written statement for the
customer to sign that accurately describes the customers financial
situation, investment experience, and investment goals, and that
contains a statement as to why the brokerage firm decided penny stocks
are a suitable investment for its customer; and
|
| |  |  | the purchasers possible legal remedies in the event our common stock
is sold to the purchaser in violation of the penny stock rules.                                                                                                                                                                                         

If we were to become subject to the SECs penny stock rules, the restrictions
noted above may make it less likely that brokers or dealers would effect
transactions in our common stock and therefore may decrease the liquidity of
our common stock and the ability of purchasers of our common stock to sell our
common stock in the secondary market.

Our stock price may be volatile, and the value of your investment may decline.

The market prices for securities of biotechnology companies in general
have been highly volatile and our stock may be subject to volatility. After
accounting for the effect of our 1-for-12 reverse stock split on April 10,
2003, during 2002 our closing stock prices

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ranged from a low of $3.24 to a high of $57.60, and ranged from a low of
$1.71 to a high of $5.73 during the six-month period ended June 30, 2003. The
following factors, in addition to the other risk factors described in this
section, may have a significant impact on the market price of our common stock:



| |  |  | announcements regarding strategic alternatives, including a merger or
sale of the company or acquisition or license of products or product
candidates;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------
|
| |  |  | publicity regarding actual or perceived adverse events in our
clinical trial or relating to products under development by us or our
competitors;      
|
| |  |  | announcements of technological innovations or new commercial products by our competitors or us;                                                       
|
| |  |  | developments concerning proprietary rights;                                                                                                           
|
| |  |  | regulatory developments in the United States or foreign countries;                                                                                    
|
| |  |  | litigation;                                                                                                                                           
|
| |  |  | significant short selling in our common stock;                                                                                                        
|
| |  |  | economic and other external factors; and                                                                                                              
|
| |  |  | period-to-period fluctuations in our financial results and changes
in analysts recommendations.                                                      

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ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK

The primary objective of our investment activities is to preserve our
capital until it is required to fund operations while at the same time
maximizing the income we receive from our investments without significantly
increasing risk. We currently have all of our funds in bank accounts and a
money market fund, which are sensitive to minimal market risk. Due to the
short-term nature of this investment, a 50 basis point movement in market
interest rates would not have a material impact on the fair value of our
investment as of June 30, 2003. We have no investments denominated in foreign
country currencies and therefore our investments are not subject to foreign
currency exchange risk.




ITEM 4. CONTROLS AND PROCEDURES

(a)  Evaluation of disclosure controls and procedures

Based on their evaluation as of the end of the period covered by this
report, our principal executive officer and principal financial officer have
concluded that IntraBiotics disclosure controls and procedures (as defined in
Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as
amended, were sufficiently effective to ensure that the information required to
be disclosed by IntraBiotics in this quarterly report on Form 10-Q was
adequately recorded, processed, summarized and reported within the time periods
specified in the Securities and Exchange Commissions rules and Form 10-Q.

(b)  Changes in internal controls

There have been no changes in our internal control over financial
reporting during the quarter ended June 30, 2003 that have materially affected,
or are reasonably likely to materially affect, our internal control over
financial reporting.

A control system, no matter how well conceived and operated, can provide
only reasonable, not absolute, assurance that the objectives of the control
system are met. Because of inherent limitations in all control systems, no
evaluation of controls can provide absolute assurance that all control issues,
if any, within a company have been detected.

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PART II. OTHER INFORMATION




ITEM 2. CHANGES IN SECURITIES AND USE OF PROCEEDS

On May 1, 2003, in a private placement transaction, the Company sold 350
shares of a newly created Series A convertible preferred stock and issued
warrants to purchase 920,699 shares of common stock for $3.5 million, resulting
in net cash proceeds after expenses of $3.2 million. The primary purpose of
completing the private placement was to provide funds for the clinical trial of
iseganan HCl for the prevention of VAP. For information relating to the terms
of conversion of the Series A preferred stock, the terms of exercise of the
warrants and the effect of the issuance of these securities on the holders of
our common stock, see Note 9 to the Condensed Financial Statements included
herein.

The securities were issued and sold pursuant to Section 4(2) of the
Securities Act of 1933, as amended. Specifically, we relied on Rule 506 of
Regulation D. All of the purchasers of the securities executed investor
questionnaires that represented that each investor was an accredited investor
as that term is defined in Rule 501 of Regulation D of the Securities Act of
1933, as amended. In addition, the requirements in Rule 502 of Regulation D
were also met. On May 15, 2003, we filed a registration statement on Form S-3
(No. 333-105288) with the Securities and Exchange Commission relating to the
resale of securities sold in the private placement transaction and on June 25,
2003 we amended that registration statement.




ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

On April 3, 2003, the Company held a special stockholder meeting to (i)
approve amendments to the Companys amended and restated certificate of
incorporation to effect a reverse split of the Companys common stock in a
range of 1:8 to 1:12 (Proposal 1), (ii) approve and ratify the sale and
issuance, in a private placement, of up to 350 shares of Series A Convertible
Preferred Stock, and warrants with proceeds of up to $3,500,000 (Proposal 2),
(iii) approve an amendment to the Companys 2000 Equity Incentive Plan to
increase the aggregate number of shares of common stock authorized for issuance
under this plan by 1,900,000 shares (Proposal 3), and (iv) approve an amendment
to the Companys certificate of incorporation to increase authorized shares of
common stock from 70,000,000 to 100,000,000 in the event the reverse stock
split in Proposal 1 was not approved by the stockholders (Proposal 4). With
respect to proposal 2, the Company adjourned the special meeting until April
23, 2003 and then adjourned special meeting again until April 30, 2003. The
voting results were as follows:

|           |  |           |            |               |  |             |           |                  |  |  |           |  |  |  |            | 
|---------- |  | --------- | ---------- | ------------- |  | ----------- | --------- | ---------------- |  |  | --------- |  |  |  | ---------- | 
|           |  | Votes for |            | Votes against |  | Abstentions |           | Broker Non-Votes
|           |  |           |            |               |  |             |           |                 
|Proposal 1 |  |           | 26,632,443 |               |  |             | 2,038,861 |                  |  |  | 23,346    |  |  |  |            | 
|Proposal 2 |  |           | 16,304,028 |               |  |             | 5,941,036 |                  |  |  | 1,300,830 |  |  |  | 15,685,457 | 
|Proposal 3 |  |           | 22,708,232 |               |  |             | 5,912,171 |                  |  |  | 74,247    |  |  |  |            | 
|Proposal 4 |  |           | 25,781,250 |               |  |             | 2,865,567 |                  |  |  | 21,347    |  |  |  | 26,486     | 

The Companys Annual Meeting of Stockholders was held on June 5, 2003. Of
the 3,269,168 shares outstanding and eligible to vote as of the record date,
2,198,243 were present or represented by proxy at the meeting. The results of
the voting on the matters submitted to the stockholders are as follows: (1) to
elect the following two directors to hold office until the 2006 Annual Meeting
of Stockholders:

|               |  |           |           |          |  |  |         | 
|-------------- |  | --------- | --------- | -------- |  |  | ------- | 
|Name           |  | Votes for |           | Withheld
|               |  |           |           |         
|Ernest Mario   |  |           | 2,057,460 |          |  |  | 140,783 | 
|Henry J. Fuchs |  |           | 2,057,460 |          |  |  | 140,783 | 

(2)  To ratify the selection by the Audit Committee of the Board of
Directors of Ernst & Young LLP as independent auditors of the Company for its
fiscal year ending December 31, 2003. The voting results were as follows:

|          |  |               |       |             |  |  |     | 
|--------- |  | ------------- | ----- | ----------- |  |  | --- | 
|Votes For |  | Votes Against |       | Abstentions
|          |  |               |       |            
|2,196,956 |  |               | 1,144 |             |  |  | 143 | 

23



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##### Table of Contents






ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

(a) List of Exhibits

|       |  |                                                                                                                                                                                                                                     
|------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Number |  | Exhibit Description                                                                                                                                                                                                                 
|       |  |                                                                                                                                                                                                                                     
|3.1    |  | Amended and Restated Certificate of Incorporation.(1)                                                                                                                                                                               
|       |  |                                                                                                                                                                                                                                     
|3.2    |  | Bylaws.(2)                                                                                                                                                                                                                          
|       |  |                                                                                                                                                                                                                                     
|4.1    |  | Amended and Restated Investor Rights Agreement dated October
15, 1999.(2)                                                                                                                                                           
|       |  |                                                                                                                                                                                                                                     
|4.2    |  | Form of Stock Purchase Agreement by and between the Company
and each selling stockholder, dated January 29, 2002.(3)                                                                                                                
|       |  |                                                                                                                                                                                                                                     
|4.3    |  | Form of Preferred Stock and Warrant Purchase Agreement,
dated February 5, 2003, as amended on February 11, 2003.(4)                                                                                                                 
|       |  |                                                                                                                                                                                                                                     
|4.4    |  | Form of Second Amendment to Preferred Stock and Warrant
Purchase Agreement of February 5, 2003, dated April 10, 2003.(5)                                                                                                            
|       |  |                                                                                                                                                                                                                                     
|4.5    |  | Form of Warrant issued by the Company pursuant to Preferred
Stock and Warrant Purchase Agreement of February 5, 2003, as
amended of February 11, 2003 and April 10, 2003.(5)                                                        
|       |  |                                                                                                                                                                                                                                     
|31.1   |  | Certification required by Rule 13a-14(a) or Rule 15d-14(a).                                                                                                                                                                         
|       |  |                                                                                                                                                                                                                                     
|31.2   |  | Certification required by Rule 13a-14(a) or Rule 15d-14(a).                                                                                                                                                                         
|       |  |                                                                                                                                                                                                                                     
|32.1   |  | Certification by the Chief Executive Officer and the Chief
Financial Officer of the Company, as required by Rule 13a14(b)
Or Rule 15d-14(b) and Section 1350 of Chapter 63 of Title 18 of
the United States. Code (18 U.S.C. 1350).



|(1) |  | Incorporated by reference to exhibit to our Form 10-K (File No.
000-29993) filed with the Securities and Exchange Commission on March 31,
2003.                                                              
|--- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|   
|(2) |  | Incorporated by reference to exhibit to our Registration Statement on
Form S-1 (File No. 333-95461) initially filed with the Securities and
Exchange Commission on January 27, 2000, as subsequently amended.
|   
|(3) |  | Incorporated by reference to exhibit to our Registration Statement on
Form S-3 (File No. 333-82934) filed with the Securities and Exchange
Commission on February 15, 2002.                                  
|   
|(4) |  | Incorporated by reference to Appendix B to the Definitive Proxy Statement
for the Special Meeting of Stockholders (File No. 000-29993) filed with
the Securities and Exchange Commission on March 3, 2003.   
|   
|(5) |  | Incorporated by reference to exhibit to our Form 10-Q (File No.
000-29993) filed with the Securities and Exchange Commission on May 14,
2003.                                                                



| | (b) |  | Reports on Form 8-K
| | --- |  | -------------------

We furnished a report on Form 8-K, dated April 29, 2003, announcing the
dissemination of a press release announcing certain financial results for the
quarter ended March 31, 2003.

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##### Table of Contents






SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

|                |  |                                      
|--------------- |  | -------------------------------------
|                |  | IntraBiotics Pharmaceuticals, Inc.   
|                |  |                                      
|                |  | /s/ Henry J. Fuchs                   
|                |  |                                      
|August 13, 2003 |  | Henry J. Fuchs, M.D.                 
|                |  | President and Chief Executive Officer
|                |  |                                      
|                |  | /s/ Eric H. Bjerkholt                
|                |  |                                      
|August 13, 2003 |  | Eric H. Bjerkholt                    
|                |  | Chief Financial Officer              

25



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##### Table of Contents






EXHIBIT INDEX

|       |  |                                                                                                                                                                                                                                     
|------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Number |  | Exhibit Description                                                                                                                                                                                                                 
|       |  |                                                                                                                                                                                                                                     
|3.1    |  | Amended and Restated Certificate of Incorporation.(1)                                                                                                                                                                               
|       |  |                                                                                                                                                                                                                                     
|3.2    |  | Bylaws.(2)                                                                                                                                                                                                                          
|       |  |                                                                                                                                                                                                                                     
|4.1    |  | Amended and Restated Investor Rights Agreement dated October
15, 1999.(2)                                                                                                                                                           
|       |  |                                                                                                                                                                                                                                     
|4.2    |  | Form of Stock Purchase Agreement by and between the Company
and each selling stockholder, dated January 29, 2002.(3)                                                                                                                
|       |  |                                                                                                                                                                                                                                     
|4.3    |  | Form of Preferred Stock and Warrant Purchase Agreement,
dated February 5, 2003, as amended on February 11, 2003.(4)                                                                                                                 
|       |  |                                                                                                                                                                                                                                     
|4.4    |  | Form of Second Amendment to Preferred Stock and Warrant
Purchase Agreement of February 5, 2003, dated April 10, 2003.(5)                                                                                                            
|       |  |                                                                                                                                                                                                                                     
|4.5    |  | Form of Warrant issued by the Company pursuant to Preferred
Stock and Warrant Purchase Agreement of February 5, 2003, as
amended of February 11, 2003 and April 10, 2003.(5)                                                        
|       |  |                                                                                                                                                                                                                                     
|31.1   |  | Certification required by Rule 13a-14(a) or Rule 15d-14(a).                                                                                                                                                                         
|       |  |                                                                                                                                                                                                                                     
|31.2   |  | Certification required by Rule 13a-14(a) or Rule 15d-14(a).                                                                                                                                                                         
|       |  |                                                                                                                                                                                                                                     
|32.1   |  | Certification by the Chief Executive Officer and the Chief
Financial Officer of the Company, as required by Rule 13a14(b)
Or Rule 15d-14(b) and Section 1350 of Chapter 63 of Title 18 of
the United States. Code (18 U.S.C. 1350).



|(1) |  | Incorporated by reference to exhibit to our Form 10-K (File No.
000-29993) filed with the Securities and Exchange Commission on March 31,
2003.                                                              
|--- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|   
|(2) |  | Incorporated by reference to exhibit to our Registration Statement on
Form S-1 (File No. 333-95461) initially filed with the Securities and
Exchange Commission on January 27, 2000, as subsequently amended.
|   
|(3) |  | Incorporated by reference to exhibit to our Registration Statement on
Form S-3 (File No. 333-82934) filed with the Securities and Exchange
Commission on February 15, 2002.                                  
|   
|(4) |  | Incorporated by reference to Appendix B to the Definitive Proxy Statement
for the Special Meeting of Stockholders (File No. 000-29993) filed with
the Securities and Exchange Commission on March 3, 2003.   
|   
|(5) |  | Incorporated by reference to our Form 10-Q (File No. 000-29993) filed
with the Securities and Exchange Commission on May 14, 2003.