Exhibit 10.105

LOAN AND SECURITY AGREEMENT

THIS LOAN AND SECURITY AGREEMENT (this
Agreement) dated as of the Effective Date between SILICON VALLEY BANK, a California corporation (Bank), and SENETEK PLC, an English corporation (Borrower), provides the terms on
which Bank shall lend to Borrower and Borrower shall repay Bank. The parties agree as follows:

1 ACCOUNTING AND OTHER TERMS

Accounting terms not defined in this Agreement shall be construed following GAAP. Calculations and determinations must be made
following GAAP. Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth in Section 13. All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to
the extent such terms are defined therein.

2 LOAN AND TERMS OF PAYMENT

2.1 Promise to Pay. Borrower hereby unconditionally promises to pay Bank the outstanding principal amount of all Credit Extensions and accrued and
unpaid interest thereon as and when due in accordance with this Agreement.

2.1.1 Revolving Advances.

(a) Availability. Subject to the terms and conditions of this Agreement, Bank shall make Advances not exceeding the Availability Amount. Amounts
borrowed under the Revolving Line may be repaid and, prior to the Revolving Line Maturity Date, reborrowed, subject to the applicable terms and conditions precedent herein.

(b) Termination; Repayment. The Revolving Line terminates on the Revolving Line Maturity Date, when the principal amount of all Advances, the
unpaid interest thereon, and all other Obligations relating to the Revolving Line shall be immediately due and payable.

(c) Early
Termination; Fee. The Revolving Line may be terminated prior to the Revolving Line Maturity Date as follows: (i) by Borrower, effective three Business Days after written notice of termination is given to Bank; or (ii) by Bank at any
time after the occurrence and during the continuance of an Event of Default, without notice, effective immediately. On the effective date of any termination of the Revolving Line under this Section 2.1.1(c), Borrower shall pay all outstanding
Obligations, and a termination fee in an amount equal to three percent per annum on the Revolving Line for the period from the effective date of termination to and including the Revolving Line Maturity Date. Said termination fee shall be due and
payable on the effective date of termination and thereafter shall bear interest at a rate equal to the highest rate applicable to any of the Obligations.

2.2 Overadvances. If, at any time, the Credit Extensions under Section 2.1.1 exceed the lesser of either (a) the Revolving Line or (b) the Borrowing Base, Borrower shall immediately pay to Bank
in cash such excess.

2.3 Payment of Interest on the Credit Extensions.

(a) Interest Rate.

(i)
Advances. Subject to Section 2.3(b), the principal amount outstanding under the Revolving Line shall accrue interest at a floating per annum rate equal to the greater of (i) one percentage point above the Prime Rate, or
(ii) 8.25% per annum, which interest shall be payable monthly in accordance with Section 2.3(f) below.

(b) Default
Rate. Immediately upon the occurrence and during the continuance of an Event of Default, Obligations shall bear interest at a rate per annum which is five percentage points above the rate effective immediately before the Event of Default (the
Default Rate). Payment or acceptance of the increased interest rate provided in this Section 2.3(b) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise
prejudice or limit any rights or remedies of Bank.



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(c) Adjustment to Interest Rate. Changes to the interest rate of any Credit Extension based on
changes to the Prime Rate shall be effective on the effective date of any change to the Prime Rate and to the extent of any such change.

(d) 360-Day Year. Interest shall be computed on the basis of a 360-day year for the actual number of days elapsed.

(e)
Debit of Accounts. Bank may debit any of Borrowers deposit accounts, including the Designated Deposit Account, for principal and interest payments or any other amounts Borrower owes Bank when due. These debits shall not constitute a
set-off.

(f) Payments. Unless otherwise provided, interest is payable monthly on the first calendar day of each month. Payments of
principal and/or interest received after 12:00 p.m. Pacific time are considered received at the opening of business on the next Business Day. When a payment is due on a day that is not a Business Day, the payment is due the next Business Day and
additional fees or interest, as applicable, shall continue to accrue.

2.4 Fees. Borrower shall pay to Bank:

(a) Commitment Fee. A fully earned, non-refundable commitment fee of $15,000, on the Effective Date;

(b) Unused Revolving Line Facility Fee. A fee (the Unused Revolving Line Facility Fee), payable quarterly, in arrears, on a
calendar year basis, in an amount equal to three percent per annum of the average unused portion of the Revolving Line, as determined by Bank. Borrower shall not be entitled to any credit, rebate or repayment of any Unused Revolving Line Facility
Fee previously earned by Bank pursuant to this Section notwithstanding any termination of the Agreement or the suspension or termination of Banks obligation to make loans and advances hereunder; and

(c) Bank Expenses. All Bank Expenses (including reasonable attorneys fees and expenses, plus expenses, for documentation and negotiation of
this Agreement) incurred through and after the Effective Date, when due.

3 CONDITIONS OF LOANS

3.1 Conditions Precedent to Initial Advance. Banks obligation to make the initial Advance is subject to the condition precedent that Bank
shall have received, in form and substance satisfactory to Bank, such documents, and completion of such other matters, as Bank may reasonably deem necessary or appropriate, including, without limitation:

(a) Borrower shall have delivered duly executed original signatures to the Loan Documents to which it is a party;

(b) [intentionally omitted];

(c) Borrower
shall have delivered its Operating Documents and a good standing certificate of Borrower certified by the Secretary of State of the State of California as of a date no earlier than thirty (30) days prior to the Effective Date;

(d) Borrower shall have delivered duly executed original signatures to the completed Borrowing Resolutions for Borrower;

(e) Bank shall have received certified copies, dated as of a recent date, of financing statement searches, as Bank shall request, accompanied by written
evidence (including any UCC termination statements) that the Liens indicated in any such financing statements either constitute Permitted Liens or have been terminated or released;



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(f) Borrower shall have delivered the Perfection Certificate executed by Borrower;

(g) Borrower shall have delivered evidence satisfactory to Bank that the insurance policies required by Section 6 hereof are in full force and
effect, together with appropriate evidence showing loss payable and/or additional insured clauses or endorsements in favor of Bank;

(h)
Borrower shall have paid the fees and Bank Expenses then due as specified in Section 2.4 hereof; and

(i) Valeant Pharmaceuticals
International, a Delaware corporation, shall have executed and delivered a Licensee Agreement to the Bank relating to the Valeant License, in the form of Exhibit A.

3.2 Conditions Precedent to all Credit Extensions. Banks obligations to make each Credit Extension, including the initial Credit Extension, is subject to the following:

(a) except as otherwise provided in Section 3.4(a), timely receipt of an executed Payment/Advance Form;

(b) the representations and warranties in Section 5 shall be true in all material respects on the date of the Payment/Advance Form and on the
Funding Date of each Credit Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further
that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date, and no Default or Event of Default shall have occurred and be continuing or result from
the Credit Extension. Each Credit Extension is Borrowers representation and warranty on that date that the representations and warranties in Section 5 remain true in all material respects; provided, however, that such materiality
qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date
shall be true, accurate and complete in all material respects as of such date; and

(c) in Banks sole discretion, there has not been
a Material Adverse Change.

3.3 Covenant to Deliver.

Borrower agrees to deliver to Bank each item required to be delivered to Bank under this Agreement as a condition to any Credit Extension. Borrower expressly agrees that the extension of a Credit Extension prior to
the receipt by Bank of any such item shall not constitute a waiver by Bank of Borrowers obligation to deliver such item, and any such extension in the absence of a required item shall be in Banks sole discretion.

3.4 Procedures for Borrowing.

(a)
Advances. Subject to the prior satisfaction of all other applicable conditions to the making of an Advance set forth in this Agreement, to obtain an Advance, Borrower shall notify Bank (which notice shall be irrevocable) by electronic mail,
facsimile, or telephone by 12:00 p.m. Pacific time on the Funding Date of the Advance. Together with any such electronic or facsimile notification, Borrower shall deliver to Bank by electronic mail or facsimile a completed Payment/Advance Form
executed by a Responsible Officer or his or her designee. Bank may rely on any telephone notice given by a person whom Bank believes is a Responsible Officer or designee. Bank shall credit Advances to the Designated Deposit Account. Bank may make
Advances under this Agreement based on instructions from a Responsible Officer or his or her designee or without instructions if the Advances are necessary to meet Obligations which have become due.

4 CREATION OF SECURITY INTEREST

4.1 Grant of Security Interest. Borrower hereby grants Bank, to secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to Bank, the Collateral, wherever located, whether
now owned or hereafter acquired or arising, and all proceeds and products thereof. Borrower represents, warrants, and covenants that the security interest granted herein is and shall at all times continue to be a first priority perfected security
interest in the Collateral (subject only to Permitted Liens that may



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have superior priority to Banks Lien under this Agreement). If Borrower shall acquire a commercial tort claim,
Borrower shall promptly notify Bank in a writing signed by Borrower of the general details thereof and grant to Bank in such writing a security interest therein and in the proceeds thereof, all upon the terms of this Agreement, with such writing to
be in form and substance reasonably satisfactory to Bank.

If this Agreement is terminated, Banks Lien in the Collateral shall
continue until the Obligations (other than inchoate indemnity obligations) are repaid in full in cash. Upon payment in full in cash of the Obligations and at such time as Banks obligation to make Credit Extensions has terminated, Bank shall,
at Borrowers sole cost and expense, release its Liens in the Collateral and all rights therein shall revert to Borrower.

4.2
Authorization to File Financing Statements. Borrower hereby authorizes Bank to file financing statements, without notice to Borrower, with all appropriate jurisdictions to perfect or protect Banks interest or rights hereunder, including a
notice that any disposition of the Collateral, by either Borrower or any other Person, shall be deemed to violate the rights of Bank under the Code.

5 REPRESENTATIONS AND WARRANTIES

Borrower represents and warrants as follows:

5.1 Due Organization and Authorization. Borrower and each of its Subsidiaries are duly existing and in good standing in their respective
jurisdictions of formation and are qualified and licensed to do business and are in good standing in any jurisdiction in which the conduct of their business or their ownership of property requires that they be qualified except where the failure to
do so could not reasonably be expected to have a material adverse effect on Borrowers business. In connection with this Agreement, Borrower has delivered to Bank a completed certificate substantially in the form attached hereto as Exhibit B
signed by Borrower, entitled Perfection Certificate. Borrower represents and warrants to Bank that (a) Borrowers exact legal name is that indicated on the Perfection Certificate and on the signature page hereof;
(b) Borrower is an organization of the type and is organized in the jurisdiction set forth in the Perfection Certificate; (c) the Perfection Certificate accurately sets forth Borrowers organizational identification number or
accurately states that Borrower has none; (d) the Perfection Certificate accurately sets forth Borrowers place of business, or, if more than one, its chief executive office as well as Borrowers mailing address (if different than its
chief executive office); (e) Borrower (and each of its predecessors) has not, in the past five (5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction;
and (f) all other information set forth on the Perfection Certificate pertaining to Borrower and each of its Subsidiaries is accurate and complete. If Borrower is not now a Registered Organization but later becomes one, Borrower shall promptly
notify Bank of such occurrence and provide Bank with Borrowers organizational identification number.

The execution, delivery and
performance of the Loan Documents have been duly authorized, and do not conflict with Borrowers organizational documents, nor constitute an event of default under any material agreement by which Borrower is bound. Borrower is not in default
under any agreement to which it is a party or by which it is bound in which the default could have a material adverse effect on Borrowers business.

Borrower does not have any Subsidiaries except for the four Subsidiaries listed in the Perfection Certificate, and the total assets of all Subsidiaries do not, and will not, during the term hereof, exceed $3,900,000
(which includes good will of $1,200,000).

5.2 Collateral. Borrower has good title to, has rights in, and the power to transfer each
item of the Collateral upon which it purports to grant a Lien hereunder, free and clear of any and all Liens except Permitted Liens. Borrower has no deposit accounts other than the deposit accounts with Bank, the deposit accounts, if any, described
in the Perfection Certificate delivered to Bank in connection herewith, or of which Borrower has given Bank notice and taken such actions as are necessary to give Bank a perfected security interest therein. The Accounts are bona fide, existing
obligations of the Account Debtors.

The Collateral is not in the possession of any third party bailee (such as a warehouse) except as
otherwise provided in the Perfection Certificate. None of the components of the Collateral shall be maintained at locations other than as provided in the Perfection Certificate or as Borrower has given Bank notice pursuant to Section 7.2. In
the event that Borrower, after the date hereof, intends to store or otherwise deliver any portion of the Collateral to a bailee, then Borrower will first receive the written consent of Bank and such bailee must execute and deliver a bailee agreement
in form and substance satisfactory to Bank in its sole discretion.



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Borrower is the sole owner of its intellectual property comprising Collateral, except for
(i) non-exclusive licenses granted to its customers in the ordinary course of business, (ii) exclusive licenses granted to its customers in the ordinary course of business, which are exclusive only as to specific channels of trade, and
(iii) the Valeant License. Each patent is valid and enforceable, and no part of the intellectual property has been judged invalid or unenforceable, in whole or in part, and to the best of Borrowers knowledge, no claim has been made that
any part of the intellectual property violates the rights of any third party except to the extent such claim could not reasonably be expected to have a material adverse effect on Borrowers business. Except as noted on the Perfection
Certificate, Borrower is not a party to, nor is bound by, any license or other agreement with respect to which Borrower is the licensee that prohibits or otherwise restricts Borrower from granting a security interest in Borrowers interest in
such license or agreement or any other property. Borrower shall provide written notice to Bank within ten days of entering or becoming bound by any such license or agreement which is reasonably likely to have a material impact on Borrowers
business or financial condition (other than over-the-counter software that is commercially available to the public). Borrower shall take such steps as Bank requests to obtain the consent of, or waiver by, any person whose consent or waiver is
necessary for all such licenses or contract rights to be deemed Collateral and for Bank to have a security interest in it that might otherwise be restricted or prohibited by law or by the terms of any such license or agreement (such
consent or authorization may include a licensors agreement to a contingent assignment of the license to Bank if Bank determines that is necessary in its good faith judgment), whether now existing or entered into in the future.

5.3 [intentionally omitted]

5.4
Litigation. There are no actions or proceedings pending or, to the knowledge of the Responsible Officers, threatened in writing by or against Borrower or any of its Subsidiaries involving more than $250,000.

5.5 No Material Deviation in Financial Statements. All consolidated financial statements for Borrower and any of its Subsidiaries delivered to
Bank fairly present in all material respects Borrowers consolidated financial condition and Borrowers consolidated results of operations, in accordance with GAAP. There has not been any material deterioration in Borrowers
consolidated financial condition since the date of the most recent financial statements submitted to Bank.

5.6 Solvency. The fair
salable value of Borrowers assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; Borrower is not left with unreasonably small capital after the transactions in this Agreement; and Borrower is able to
pay its debts (including trade debts) as they mature.

5.7 Regulatory Compliance. Borrower is not an investment company
or a company controlled by an investment company under the Investment Company Act. Borrower is not engaged as one of its important activities in extending credit for margin stock (under Regulations T and U of the Federal
Reserve Board of Governors). Borrower has complied in all material respects with the Federal Fair Labor Standards Act. Borrower has not violated any laws, ordinances or rules, the violation of which could reasonably be expected to have a material
adverse effect on its business. None of Borrowers or any of its Subsidiaries properties or assets has been used by Borrower or any Subsidiary or, to the best of Borrowers knowledge, by previous Persons, in disposing, producing,
storing, treating, or transporting any hazardous substance other than legally. Borrower and each of its Subsidiaries have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all
government authorities that are necessary to continue its business as currently conducted.

5.8 Subsidiaries; Investments. Borrower
does not own any stock, partnership interest or other equity securities except for Permitted Investments, and existing investments in existing Subsidiaries.

5.9 Tax Returns and Payments; Pension Contributions. Borrower has timely filed all required tax returns and reports, and Borrower has timely paid all foreign, federal, state and local taxes, assessments,
deposits and contributions owed by Borrower. Borrower may defer payment of any contested taxes, provided that Borrower (a) in good faith contests its obligation to pay the taxes by appropriate proceedings promptly and diligently instituted and
conducted, (b) notifies Bank in writing of the commencement of, and any material development in, the proceedings, (c) posts bonds or takes any other steps required to prevent the governmental authority levying such contested taxes from
obtaining a Lien upon any of the Collateral that is other than a Permitted Lien. Borrower is



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unaware of any claims or adjustments proposed for any of Borrowers prior tax years which could result in additional
taxes becoming due and payable by Borrower. Borrower does not and has not sponsored or contributed to any pension, profit sharing or deferred compensation plans, and Borrower has not withdrawn from participation in, and has not permitted partial or
complete termination of, or permitted the occurrence of any other event with respect to, any such plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or
its successors or any other governmental agency.

5.10 Use of Proceeds. Borrower shall use the proceeds of the Credit Extensions
solely as working capital, and to fund its general business requirements and not for personal, family, household or agricultural purposes.

5.11 Full Disclosure. No written representation, warranty or other statement of Borrower in any certificate or written statement given to Bank, as of the date such representations, warranties, or other statements were made, taken
together with all such written certificates and written statements given to Bank, contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements contained in the certificates or statements not
misleading (it being recognized by Bank that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not viewed as facts and that actual results during the period or periods covered by such
projections and forecasts may differ from the projected or forecasted results).

6 AFFIRMATIVE COVENANTS

Borrower shall do all of the following:

6.1 Government Compliance. Maintain its and all its Subsidiaries legal existence and good standing in their respective jurisdictions of formation and maintain qualification in each jurisdiction in which the failure to so
qualify would reasonably be expected to have a material adverse effect on Borrowers business or operations. Borrower shall comply, and have each Subsidiary comply, with all laws, ordinances and regulations to which it is subject, noncompliance
with which could have a material adverse effect on Borrowers business.

6.2 Financial Statements, Reports, Certificates.

(a) Deliver to Bank:



| | (i) | as soon as available, but no later than 30 days after the last day of each month, a company prepared consolidated balance sheet and income statement covering Borrowers
and each of its Subsidiaries operations during the period certified by a Responsible Officer and in a form acceptable to Bank;
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| | (ii) | as soon as available, but no later than 120days after the last day of Borrowers fiscal year, audited consolidated financial statements prepared under GAAP,
consistently applied, together with an unqualified opinion on the financial statements from an independent certified public accounting firm acceptable to Bank in its reasonable discretion;
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| | (iii) | within five (5) days of delivery, copies of all statements, reports and notices made available to Borrowers security holders or to any holders of Subordinated Debt;
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| | (iv) | within five (5) days of filing, all reports on Form 10-K, 10-Q and 8-K filed with the Securities and Exchange Commission or a link thereto on Borrowers or another website
on the Internet;
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| | (v) | a prompt report of any legal actions pending or threatened against Borrower or any of its Subsidiaries that could result in damages or costs to Borrower or any of its Subsidiaries
of $250,000 or more;
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| | (vi) | prompt notice of any event that materially and adversely affects the value of the intellectual property; and
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| | (vii) | budgets, sales projections, operating plans and other financial information reasonably requested by Bank.
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(b) Within 30 days after the last day of each month, deliver to Bank a duly completed Borrowing Base Certificate signed by a Responsible Officer, with an
aged listings of accounts receivable and accounts payable (by invoice date).

(c) Within 30 days after the last day of each month, deliver
to Bank with the monthly financial statements, a duly completed Compliance Certificate signed by a Responsible Officer, setting forth calculations showing compliance with the financial covenants set forth in this Agreement.

(d) Allow Bank to audit Borrowers Collateral at Borrowers expense.

6.3 [intentionally omitted]

6.4
Taxes; Pensions. Make, and cause each of its Subsidiaries to make, timely payment of all foreign, federal, state, and local taxes or assessments (other than taxes and assessments which Borrower is contesting pursuant to the terms of
Section 5 hereof) and shall deliver to Bank, on demand, appropriate certificates attesting to such payments, and pay all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with their
terms.

6.5 Insurance. Keep its business and the Collateral insured for risks and in amounts standard for companies in
Borrowers industry and location and as Bank may reasonably request. Insurance policies shall be in a form, with companies, and in amounts that are satisfactory to Bank. All property policies shall have a lenders loss payable endorsement
showing Bank as the sole lender loss payee and waive subrogation against Bank, and all liability policies shall show, or have endorsements showing, Bank as an additional insured. All policies (or the loss payable and additional insured endorsements)
shall provide that the insurer must give Bank at least twenty (20) days notice before canceling, amending, or declining to renew its policy. At Banks request, Borrower shall deliver certified copies of policies and evidence of all premium
payments. Proceeds payable under any policy shall, at Banks option, be payable to Bank on account of the Obligations. If Borrower fails to obtain insurance as required under this Section 6.5 or to pay any amount or furnish any required
proof of payment to third persons and Bank, Bank may make all or part of such payment or obtain such insurance policies required in this Section 6.5, and take any action under the policies Bank deems prudent.

6.6 Operating Accounts.

(a) Maintain
its and its Subsidiaries primary depository and operating accounts and securities accounts with Bank and Banks affiliates,which accounts shall represent at least 85% of the dollar value of Borrowers and such
Subsidiaries accounts at all financial institutions.

6.7 Financial Covenants.

Borrower shall maintain at all times, on a consolidated basis with respect to Borrower and its Subsidiaries:

(a) EBITDA. Maintain EBITDA of at least $1.00 for each rolling three-month period ending at the end of each month, commencing with the three month
period ending March 31, 2006, and continuing for the three month period ending April 30, 2006 and each rolling three-month period ending at the end of each month thereafter.

(b) Cash at Bank. Maintain, at all times, cash in Deposit Accounts at Bank of not less than $300,000.



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6.8 Protection and Registration of Intellectual Property Rights. Borrower shall: (a) protect,
defend and maintain the validity and enforceability of its intellectual property; (b) promptly advise Bank in writing of material infringements of its intellectual property; and (c) not allow any intellectual property material to
Borrowers business to be abandoned, forfeited or dedicated to the public without Banks written consent. If Borrower decides to register any copyrights or mask works related to any Collateral in the United States Copyright Office,
Borrower shall: (x) provide Bank with at least fifteen (15) days prior written notice of its intent to register such copyrights or mask works together with a copy of the application it intends to file with the United States Copyright
Office (excluding exhibits thereto); (y) execute an intellectual property security agreement or such other documents as Bank may reasonably request to maintain the perfection and priority of Banks security interest in the copyrights or
mask works intended to be registered with the United States Copyright Office; and (z) record such intellectual property security agreement with the United States Copyright Office contemporaneously with filing the copyright or mask work
application(s) with the United States Copyright Office. Borrower shall promptly provide to Bank a copy of the application(s) filed with the United States Copyright Office together with evidence of the recording of the intellectual property security
agreement necessary for Bank to maintain the perfection and priority of its security interest in such copyrights or mask works. Borrower shall provide written notice to Bank of any application filed by Borrower in the United States Patent and
Trademark Office for a patent or to register a trademark or service mark within 30 days after any such filing.

6.9 Litigation
Cooperation. From the date hereof and continuing through the termination of this Agreement, make available to Bank, without expense to Bank, Borrower and its officers, employees and agents and Borrowers books and records, to the extent
that Bank may deem them reasonably necessary to prosecute or defend any third-party suit or proceeding instituted by or against Bank with respect to any Collateral or relating to Borrower.

6.10 Valeant License. Borrower shall not modify or amend the Valeant License or waive any rights thereunder or agree to any modification or change
to any minimum royalties thereunder, without the prior written consent of the Bank, which shall be a matter of Banks good faith business judgment. Borrower shall not transfer the Valeant License or any rights thereunder or interest therein.
Borrower shall promptly provide Bank with copies of all material correspondence sent by or received by Borrower, relating to the Valeant License, including without limitation any notice of any default or claim asserted by Borrower or the licensee
under or relating to the Valeant License. Borrower represents and warrants that it has provided Bank with true and correct copies of the Valeant License (including all amendments thereto) and the same is presently in full force and effect.

6.11 Further Assurances. Borrower shall execute any further instruments and take further action as Bank reasonably requests to
perfect or continue Banks Lien in the Collateral or to effect the purposes of this Agreement.

7 NEGATIVE COVENANTS

Borrower shall not do any of the following without Banks prior written consent:

7.1 Dispositions. Convey, sell, lease, transfer or otherwise dispose of (collectively, Transfer), or permit any of its
Subsidiaries to Transfer, all or any part of its business, assets or property, except for Transfers (a) of Inventory in the ordinary course of business; (b) of worn-out or obsolete Equipment; and (c) in connection with Permitted Liens
and Permitted Investments. Without limiting the generality of the foregoing, Borrower will not, during the term of this Agreement, make any payments or transfers of money, property, rights or assets of any kind or nature, in any transaction of any
kind or nature (including without limitation sales, loans, repayment of loans, capital contributions, purchases, loans, compensation arrangements, consulting fees, management fees, licenses, or any other transaction of any kind or nature) to any of
its Subsidiaries, without the prior written consent of the Bank, except for intercompany loans in an amount necessary to fund the current operating expenses of the Subsidiaries, taking into account their revenue from other sources, in an aggregate
amount for all Subsidiaries not to exceed $250,000 in any fiscal year of Borrower.

7.2 Changes in Business, Management, Ownership,
Control, or Business Locations. (a) Engage in or permit any of its Subsidiaries to engage in any business other than the businesses currently engaged in by Borrower and such Subsidiary, as applicable, or reasonably related thereto;
(b) liquidate or dissolve; or (c) (i) if a Key Person ceases to hold such office with Borrower and replacements satisfactory to Bank are not made within 30 days after his departure from Borrower, or (ii) permit or suffer
any Change in Control. Borrower shall not, without



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at least thirty (30) days prior written notice to Bank: (1) add any new offices or business locations,
including warehouses (unless such new offices or business locations contain less than $10,000 in Borrowers assets or property), (2) change its jurisdiction of organization, (3) change its organizational structure or type,
(4) change its legal name, or (5) change any organizational number (if any) assigned by its jurisdiction of organization.

7.3
Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property
of another Person. A Subsidiary may merge or consolidate into another Subsidiary or into Borrower.

7.4 Indebtedness. Create, incur,
assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other than Permitted Indebtedness.

7.5 Encumbrance.
Create, incur, or allow any Lien on any of the Collateral, or assign or convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, permit any Collateral not to be
subject to the first priority security interest granted herein, except as is otherwise permitted in Section 7.1 hereof and the definition of Permitted Lien herein.

7.6 [intentionally omitted]

7.7
Investments; Distributions. (a) Directly or indirectly make any Investment other than Permitted Investments, or permit any of its Subsidiaries to do so; or (b) pay any dividends or make any distribution or payment or redeem, retire or
purchase any capital stock.

7.8 Transactions with Affiliates. Directly or indirectly enter into or permit to exist any material
transaction with any Affiliate of Borrower, except for transactions that are in the ordinary course of Borrowers business, upon fair and reasonable terms that are no less favorable to Borrower than would be obtained in an arms length
transaction with a non-affiliated Person.

7.9 Subordinated Debt. (a) Make or permit any payment on any Subordinated Debt,
except under the terms of the subordination, intercreditor, or other similar agreement to which such Subordinated Debt is subject, or (b) amend any provision in any document relating to the Subordinated Debt which would increase the amount
thereof or adversely affect the subordination thereof to Obligations owed to Bank.

7.10 Compliance. Become an investment
company or a company controlled by an investment company, under the Investment Company Act of 1940 or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of
the Board of Governors of the Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to
occur; fail to comply with the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation could reasonably be expected to have a material adverse effect on Borrowers business, or permit any of its Subsidiaries to
do so; withdraw or permit any Subsidiary to withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any present pension, profit sharing and deferred compensation plan
which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency.

8 EVENTS OF DEFAULT

Any one
of the following shall constitute an event of default (an Event of Default) under this Agreement:

8.1 Payment
Default. Borrower fails to (a) make any payment of principal or interest on any Credit Extension on its due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable. During
the cure period, the failure to cure the payment default is not an Event of Default (but no Credit Extension will be made during the cure period);



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8.2 Covenant Default.

(a) Borrower fails or neglects to perform any obligation in Sections 6.2, 6.6, or 6.7 or violates any covenant in Section 7; or

(b) Borrower fails or neglects to perform, keep, or observe any other term, provision, condition, covenant or agreement contained in this Agreement, any
Loan Documents, and as to any default (other than those specified in this Section 8) under such other term, provision, condition, covenant or agreement that can be cured, has failed to cure the default within ten (10) days after the
occurrence thereof; provided, however, that if the default cannot by its nature be cured within the ten (10) day period or cannot after diligent attempts by Borrower be cured within such ten (10) day period, and such default is likely to
be cured within a reasonable time, then Borrower shall have an additional period (which shall not in any case exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall
not be deemed an Event of Default (but no Credit Extensions shall be made during such cure period). Grace periods provided under this section shall not apply, among other things, to financial covenants or any other covenants set forth in subsection
(a) above;

8.3 Material Adverse Change. A Material Adverse Change occurs;

8.4 Attachment. (a) Any material portion of Borrowers assets is attached, seized, levied on, or comes into possession of a trustee or
receiver and the attachment, seizure or levy is not removed in ten (10) days; (b) the service of process upon Bank seeking to attach, by trustee or similar process, any funds of Borrower or of any entity under control of Borrower
(including a Subsidiary) on deposit with Bank; (c) Borrower is enjoined, restrained, or prevented by court order from conducting a material part of its business; (d) a judgment or other claim in excess of $10,000 becomes a Lien on any of
Borrowers assets; or (e) a notice of lien, levy, or assessment is filed against any of Borrowers assets by any government agency and not paid within ten (10) days after Borrower receives notice. These are not Events of Default
if stayed or if a bond is posted pending contest by Borrower (but no Credit Extensions shall be made during the cure period);

8.5
Insolvency. Borrower is unable to pay its debts (including trade debts) as they become due or otherwise becomes insolvent; (b) Borrower begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against Borrower and not
dismissed or stayed within thirty (30) days (but no Credit Extensions shall be made while of any of the conditions described in clause (a) exist and/or until any Insolvency Proceeding is dismissed);

8.6 Other Agreements. There is a default in any agreement to which Borrower or any Guarantor is a party with a third party or parties resulting in
a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of $50,000 or that could have a material adverse effect on Borrowers or any Guarantors business;

8.7 Judgments. A judgment or judgments for the payment of money in an amount, individually or in the aggregate, of at least $50,000
(not covered by independent third-party insurance) shall be rendered against Borrower and shall remain unsatisfied and unstayed for a period of ten (10) days after the entry thereof (provided that no Credit Extensions will be made prior to the
satisfaction or stay of such judgment);

8.8 Misrepresentations. Borrower or any Person acting for Borrower makes any
representation, warranty, or other statement now or later in this Agreement, any Loan Document or in any writing delivered to Bank or to induce Bank to enter this Agreement or any Loan Document, and such representation, warranty, or other statement
is incorrect in any material respect when made;

8.9 Subordinated Debt. A default or breach occurs under any agreement between
Borrower and any creditor of Borrower that signed a subordination, intercreditor, or other similar agreement with Bank, or any creditor that has signed such an agreement with Bank breaches any terms of such agreement; or

8.10 Valeant License.Any default or event of default occurs under the Valeant License, or any party thereto contests or denies any liability
thereunder, or asserts that a default or event of default has occurred, or the licensee under the Valeant License becomes subject to any Insolvency Proceeding or becomes insolvent or ceases to do business.



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9 BANKS RIGHTS AND REMEDIES

9.1 Rights and Remedies. While an Event of Default occurs and continues Bank may, without notice or demand, do any or all of the following:

(a) declare all Obligations immediately due and payable (but if an Event of Default described in Section 8.5 occurs all Obligations
are immediately due and payable without any action by Bank);

(b) stop advancing money or extending credit for Borrowers benefit
under this Agreement or under any other agreement between Borrower and Bank;

(c) demand that Borrower (i) deposits cash with Bank in
an amount equal to the aggregate amount of any Letters of Credit remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and Borrower shall forthwith deposit and pay such amounts, and
(ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the remaining term of any Letters of Credit;

(d)
settle or adjust disputes and claims directly with Account Debtors for amounts on terms and in any order that Bank considers advisable, notify any Person owing Borrower money of Banks security interest in such funds, and verify the amount of
such account;

(e) make any payments and do any acts it considers necessary or reasonable to protect the Collateral and/or its security
interest in the Collateral. Borrower shall assemble the Collateral if Bank requests and make it available as Bank designates. Bank may enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and
pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Borrower grants Bank a license to enter and occupy any of its premises, without charge, to exercise any of
Banks rights or remedies;

(f) apply to the Obligations any (i) balances and deposits of Borrower it holds, or (ii) any
amount held by Bank owing to or for the credit or the account of Borrower;

(g) ship, reclaim, recover, store, finish, maintain, repair,
prepare for sale, advertise for sale, and sell the Collateral. Bank is hereby granted a non-exclusive, royalty-free license or other right to use, without charge, Borrowers labels, patents, copyrights, mask works, rights of use of any name,
trade secrets, trade names, trademarks, service marks, and advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with
Banks exercise of its rights under this Section, Borrowers rights under all licenses and all franchise agreements inure to Banks benefit;

(h) place a hold on any account maintained with Bank and/or deliver a notice of exclusive control, any entitlement order, or other directions or instructions pursuant to any Control Agreement or similar
agreements providing control of any Collateral;

(i) demand and receive possession of Borrowers Books; and

(j) exercise all rights and remedies available to Bank under the Loan Documents or at law or equity, including all remedies provided under the Code
(including disposal of the Collateral pursuant to the terms thereof).

9.2 Power of Attorney. Borrower hereby irrevocably appoints
Bank as its lawful attorney-in-fact, exercisable upon the occurrence and during the continuance of an Event of Default, to: (a) endorse Borrowers name on any checks or other forms of payment or security; (b) sign Borrowers name
on any invoice or bill of lading for any Account or drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with Account Debtors, for amounts and on terms Bank determines reasonable; (d) make,
settle, and adjust all claims under Borrowers insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security interest, and adverse claim in or to the Collateral, or any judgment based thereon, or otherwise take any
action to terminate or discharge the same; and (f) transfer the Collateral into the name of Bank or a third party as the Code permits. Borrower hereby appoints Bank as its lawful attorney-in-fact to sign Borrowers name on any documents
necessary to perfect or continue the perfection of any security interest regardless of whether an Event of Default has



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occurred until all Obligations have been satisfied in full and Bank is under no further obligation to make Credit
Extensions hereunder. Banks foregoing appointment as Borrowers attorney in fact, and all of Banks rights and powers, coupled with an interest, are irrevocable until all Obligations have been fully repaid and performed and
Banks obligation to provide Credit Extensions terminates.

9.3 Accounts Verification; Collection. Whether or not an Event of
Default has occurred and is continuing, Bank may notify any Person owing Borrower money of Banks security interest in such funds and verify the amount of such account. After the occurrence of an Event of Default, any amounts received by
Borrower shall be held in trust by Borrower for Bank, and, if requested by Bank, Borrower shall immediately deliver such receipts to Bank in the form received from the Account Debtor, with proper endorsements for deposit.

9.4 Protective Payments. If Borrower fails to obtain the insurance called for by Section 6.5 or fails to pay any premium thereon or fails to
pay any other amount which Borrower is obligated to pay under this Agreement or any other Loan Document, Bank may obtain such insurance or make such payment, and all amounts so paid by Bank are Bank Expenses and immediately due and payable, bearing
interest at the then highest applicable rate, and secured by the Collateral. Bank will make reasonable efforts to provide Borrower with notice of Bank obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No
payments by Bank are deemed an agreement to make similar payments in the future or Banks waiver of any Event of Default.

9.5
Application of Payments and Proceeds. Unless an Event of Default has occurred and is continuing, Bank shall apply any funds in its possession, whether from Borrower account balances, payments, or proceeds realized as the result of any collection
of Accounts or other disposition of the Collateral, first, to Bank Expenses, including without limitation, the reasonable costs, expenses, liabilities, obligations and attorneys fees incurred by Bank in the exercise of its rights under this
Agreement; second, to the interest due upon any of the Obligations; and third, to the principal of the Obligations and any applicable fees and other charges, in such order as Bank shall determine in its sole discretion. Any surplus shall be paid to
Borrower or other Persons legally entitled thereto; Borrower shall remain liable to Bank for any deficiency. If an Event of Default has occurred and is continuing, Bank may apply any funds in its possession, whether from Borrower account balances,
payments, proceeds realized as the result of any collection of Accounts or other disposition of the Collateral, or otherwise, to the Obligations in such order as Bank shall determine in its sole discretion. Any surplus shall be paid to Borrower or
other Persons legally entitled thereto; Borrower shall remain liable to Bank for any deficiency. If Bank, in its good faith business judgment, directly or indirectly enters into a deferred payment or other credit transaction with any purchaser at
any sale of Collateral, Bank shall have the option, exercisable at any time, of either reducing the Obligations by the principal amount of the purchase price or deferring the reduction of the Obligations until the actual receipt by Bank of cash
therefor.

9.6 Banks Liability for Collateral. So long as Bank complies with reasonable banking practices regarding the
safekeeping of the Collateral in the possession or under the control of Bank, Bank shall not be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral; (c) any diminution in the
value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person. Borrower bears all risk of loss, damage or destruction of the Collateral.

9.7 No Waiver; Remedies Cumulative. Banks failure, at any time or times, to require strict performance by Borrower of any provision of this
Agreement or any other Loan Document shall not waive, affect, or diminish any right of Bank thereafter to demand strict performance and compliance herewith or therewith. No waiver hereunder shall be effective unless signed by Bank and then is only
effective for the specific instance and purpose for which it is given. Banks rights and remedies under this Agreement and the other Loan Documents are cumulative. Bank has all rights and remedies provided under the Code, by law, or in equity.
Banks exercise of one right or remedy is not an election, and Banks waiver of any Event of Default is not a continuing waiver. Banks delay in exercising any remedy is not a waiver, election, or acquiescence.

9.8 Demand Waiver. Borrower waives demand, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at
maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees held by Bank on which Borrower is liable.



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10 NOTICES

All notices, consents, requests, approvals, demands, or other communications (collectively, Communication) by any party to this Agreement or any other Loan Document must be in writing and shall be
deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first class, registered or certified mail return receipt requested, with proper
postage prepaid; (b) upon transmission, when sent by electronic mail or facsimile transmission; (c) one (1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if
hand-delivered by messenger, all of which shall be addressed to the party to be notified and sent to the address, facsimile number, or email address indicated below. Bank or Borrower may change its address or facsimile number by giving the other
party written notice thereof in accordance with the terms of this Section 10.



|                |  |                           
|--------------- |  | --------------------------
|If to Borrower: |  | Senetek PLC               
|                |  | 831 Latour Court, Suite A 
|                |  | Napa, California 94558    
|                |  | Attn: Mr. Frank J. Massino
|                |  | Fax: 707-259-6241         
|                |  | Email: frank@senetek.net  
|                | 
|If to Bank:     |  | Silicon Valley Bank       
|                |  | 185 Berry St.             
|                |  | San Francisco, CA 94107   
|                |  | Attn: Mr. Jason Hughes    
|                |  | Fax: 415-856-0810         
|                |  | Email: JHughes@svbank.com 

11 CHOICE OF LAW, VENUE, JURY TRIAL WAIVER, AND JUDICIAL REFERENCE

California law governs the Loan Documents without regard to principles of conflicts of law. Borrower and Bank each submit to the exclusive jurisdiction of
the State and Federal courts in Santa Clara County, California; provided, however, that nothing in this Agreement shall be deemed to operate to preclude Bank from bringing suit or taking other legal action in any other jurisdiction to realize on the
Collateral or any other security for the Obligations, or to enforce a judgment or other court order in favor of Bank. Borrower expressly submits and consents in advance to such jurisdiction in any action or suit commenced in any such court, and
Borrower hereby waives any objection that it may have based upon lack of personal jurisdiction, improper venue, or forum non conveniens and hereby consents to the granting of such legal or equitable relief as is deemed appropriate by such court.
Borrower hereby waives personal service of the summons, complaints, and other process issued in such action or suit and agrees that service of such summons, complaints, and other process may be made by registered or certified mail addressed to
Borrower at the address set forth in Section 10 of this Agreement and that service so made shall be deemed completed upon the earlier to occur of Borrowers actual receipt thereof or three (3) days after deposit in the U.S. mails,
proper postage prepaid.

TO THE EXTENT PERMITTED BY APPLICABLE LAW, BORROWER AND BANK EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY
CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER
INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL.

WITHOUT INTENDING IN ANY WAY TO LIMIT THE PARTIES
AGREEMENT TO WAIVE THEIR RESPECTIVE RIGHT TO A TRIAL BY JURY, if the above waiver of the right to a trial by jury is not enforceable, the parties hereto agree that any and all disputes or controversies of any nature between them arising at any time
shall be decided by a reference to a private judge, mutually selected by the parties (or, if they cannot agree, by the Presiding Judge of the Santa Clara County, California Superior Court) appointed in accordance with California Code of Civil
Procedure Section 638 (or pursuant to comparable provisions of federal law if the dispute falls within the exclusive jurisdiction of the federal courts), sitting without a jury, in Santa Clara County, California; and the parties hereby submit
to the jurisdiction of such court. The reference proceedings shall be conducted pursuant to and in



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accordance with the provisions of California Code of Civil Procedure §§ 638 through 645.1, inclusive. The
private judge shall have the power, among others, to grant provisional relief, including without limitation, entering temporary restraining orders, issuing preliminary and permanent injunctions and appointing receivers. All such proceedings shall be
closed to the public and confidential and all records relating thereto shall be permanently sealed. If during the course of any dispute, a party desires to seek provisional relief, but a judge has not been appointed at that point pursuant to the
judicial reference procedures, then such party may apply to the Santa Clara County, California Superior Court for such relief. The proceeding before the private judge shall be conducted in the same manner as it would be before a court under the
rules of evidence applicable to judicial proceedings. The parties shall be entitled to discovery which shall be conducted in the same manner as it would be before a court under the rules of discovery applicable to judicial proceedings. The private
judge shall oversee discovery and may enforce all discovery rules and order applicable to judicial proceedings in the same manner as a trial court judge. The parties agree that the selected or appointed private judge shall have the power to decide
all issues in the action or proceeding, whether of fact or of law, and shall report a statement of decision thereon pursuant to the California Code of Civil Procedure § 644(a). Nothing in this paragraph shall limit the right of any party at any
time to exercise self-help remedies, foreclose against collateral, or obtain provisional remedies. The private judge shall also determine all issues relating to the applicability, interpretation, and enforceability of this paragraph.

12 GENERAL PROVISIONS

12.1
Successors and Assigns. This Agreement binds and is for the benefit of the successors and permitted assigns of each party. Borrower may not assign this Agreement or any rights or obligations under it without Banks prior written consent
(which may be granted or withheld in Banks discretion). Bank has the right, without the consent of or notice to Borrower, to sell, transfer, negotiate, or grant participation in all or any part of, or any interest in, Banks obligations,
rights, and benefits under this Agreement and the other Loan Documents.

12.2 Indemnification. Borrower agrees to indemnify, defend
and hold Bank and its directors, officers, employees, agents, attorneys, or any other Person affiliated with or representing Bank harmless against: (a) all obligations, demands, claims, and liabilities (collectively, Claims)
asserted by any other party in connection with the transactions contemplated by the Loan Documents; and (b) all losses or Bank Expenses incurred, or paid by Bank from, following, or arising from transactions between Bank and Borrower (including
reasonable attorneys fees and expenses), except for Claims and/or losses directly caused by Banks gross negligence or willful misconduct.

12.3 Limitation of Actions.Any claim or cause of action by Borrower against Bank, its directors, officers, employees, agents, accountants, attorneys, or any other Person affiliated with or representing
Bank based upon, arising from, or relating to this Loan Agreement or any other Loan Document, or any other transaction contemplated hereby or thereby or relating hereto or thereto, or any other matter, cause or thing whatsoever, occurred, done,
omitted or suffered to be done by Bank, its directors, officers, employees, agents, accountants or attorneys, shall be barred unless asserted by Borrower by the commencement of an action or proceeding in a court of competent jurisdiction by
(a) the filing of a complaint within one year from the earlier of (i) the date any of Borrowers officers or directors had knowledge of the first act, the occurrence or omission upon which such claim or cause of action, or any part
thereof, is based, or (ii) the date this Agreement is terminated, and (b) the service of a summons and complaint on an officer of Bank, or on any other person authorized to accept service on behalf of Bank, within thirty (30) days
thereafter. Borrower agrees that such one-year period is a reasonable and sufficient time for Borrower to investigate and act upon any such claim or cause of action. The one-year period provided herein shall not be waived, tolled, or extended except
by the written consent of Bank in its sole discretion. This provision shall survive any termination of this Loan Agreement or any other Loan Document.

12.4 Time of Essence. Time is of the essence for the performance of all Obligations in this Agreement.

12.5 Severability of Provisions. Each provision of this Agreement is severable from every other provision in determining the enforceability of any provision.

12.6 Amendments in Writing; Integration. All amendments to this Agreement must be in writing signed by both Bank and Borrower. This Agreement and
the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject
matter of this Agreement and the Loan Documents merge into this Agreement and the Loan Documents.



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12.7 Counterparts. This Agreement may be executed in any number of counterparts and by different
parties on separate counterparts, each of which, when executed and delivered, are an original, and all taken together, constitute one Agreement.

12.8 Survival. All covenants, representations and warranties made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and
any other obligations which, by their terms, are to survive the termination of this Agreement) have been satisfied. The obligation of Borrower in Section 12.2 to indemnify Bank shall survive until the statute of limitations with respect to such
claim or cause of action shall have run.

12.9 Confidentiality. In handling any confidential information, Bank shall exercise the
same degree of care that it exercises for its own proprietary information, but disclosure of information may be made: (a) to Banks Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the Credit
Extensions (provided, however, Bank shall use commercially reasonable efforts to obtain such prospective transferees or purchasers agreement to the terms of this provision); (c) as required by law, regulation, subpoena, or other
order; (d) to Banks regulators or as otherwise required in connection with Banks examination or audit; and (e) as Bank considers appropriate in exercising remedies under this Agreement. Confidential information does not include
information that either: (i) is in the public domain or in Banks possession when disclosed to Bank, or becomes part of the public domain after disclosure to Bank; or (ii) is disclosed to Bank by a third party, if Bank does not know
that the third party is prohibited from disclosing the information.

12.10 Attorneys Fees, Costs and Expenses. In any action
or proceeding between Borrower and Bank arising out of or relating to the Loan Documents, the prevailing party shall be entitled to recover its reasonable attorneys fees and other costs and expenses incurred, in addition to any other relief to
which it may be entitled.

13 DEFINITIONS

13.1 Definitions. As used in this Agreement, the following terms have the following meanings:

Account is any account as defined in the Code with such additions to such term as may hereafter be made, and includes, without limitation, all accounts receivable and other sums owing to Borrower.

Account Debtor is any account debtor as defined in the Code with such additions to such term as may hereafter be made.

Advance or Advances means an advance (or advances) under the Revolving Line.

Affiliate of any Person is a Person that owns or controls directly or indirectly the Person, any Person that controls or is controlled
by or is under common control with the Person, and each of that Persons senior executive officers, directors, partners and, for any Person that is a limited liability company, that Persons managers and members.

Agreement is defined in the preamble hereof.

Availability Amount is (a) the lesser of (i) the Revolving Line or (ii) the Borrowing Base, minus (b) the outstanding principal balance of any Advances.

Bank is defined in the preamble hereof.

Bank Expenses are all audit fees and expenses, costs, and expenses (including reasonable attorneys fees and expenses) for preparing, negotiating, administering, defending and enforcing the
Loan Documents (including, without limitation, those incurred in connection with appeals or Insolvency Proceedings) or otherwise incurred with respect to Borrower.



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Bankruptcy-Related Defaults is defined in Section 9.1.

Borrower is defined in the preamble hereof

Borrowers Books are all Borrowers books and records including ledgers, federal and state tax returns, records regarding Borrowers assets or liabilities, the Collateral, business
operations or financial condition, and all computer programs or storage or any equipment containing such information.

Borrowing
Base is, at any date, 80% of the total minimum payments under the Valeant License coming due in the next four calendar quarters, as determined from time to time by the Bank; provided, however, that Bank may decrease the foregoing
percentage in its good faith business judgment based on events, conditions, contingencies, or risks which, as determined by Bank, may adversely affect the Valeant License or the other Collateral.

Borrowing Base Certificate is that certain certificate in the form attached hereto as Exhibit C.

Borrowing Resolutions are, with respect to any Person, those resolutions adopted by such Persons Board of Directors and
delivered by such Person to Bank approving the Loan Documents to which such Person is a party and the transactions contemplated thereby, together with a certificate executed by its secretary on behalf of such Person certifying that (a) such
Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that attached as Exhibit A to such certificate is a true, correct, and complete copy of the resolutions then
in full force and effect authorizing and ratifying the execution, delivery, and performance by such Person of the Loan Documents to which it is a party, (c) the name(s) of the Person(s) authorized to execute the Loan Documents on behalf of such
Person, together with a sample of the true signature(s) of such Person(s), and (d) that Bank may conclusively rely on such certificate unless and until such Person shall have delivered to Bank a further certificate canceling or amending such
prior certificate.

Business Day is any day that is not a Saturday, Sunday or a day on which Bank is closed.

Cash Equivalents means (a) marketable direct obligations issued or unconditionally guaranteed by the United States or any
agency or any State thereof having maturities of not more than one (1) year from the date of acquisition; (b) commercial paper maturing no more than one (1) year after its creation and having the highest rating from either
Standard & Poors Ratings Group or Moodys Investors Service, Inc., (c) Banks certificates of deposit issued maturing no more than one (1) year after issue; and (d) money market funds at least ninety-five
percent (95%) of the assets of which constitute Cash Equivalents of the kinds described in clauses (a) through (c) of this definition.

Change in Control means any event, transaction, or occurrence as a result of which (a) any person (as such term is defined in Sections 3(a)(9) and 13(d)(3) of the Securities
Exchange Act of 1934, as an amended (the Exchange Act)), other than a trustee or other fiduciary holding securities under an employee benefit plan of Borrower, is or becomes a beneficial owner (within the meaning Rule 13d-3
promulgated under the Exchange Act), directly or indirectly, of securities of Borrower, representing 25% or more of the combined voting power of Borrowers then outstanding securities; or (b) during any period of twelve consecutive
calendar months, individuals who at the beginning of such period constituted the Board of Directors of Borrower (together with any new directors whose election by the Board of Directors of Borrower was approved by a vote of at least two-thirds of
the directors then still in office who either were directions at the beginning of such period or whose election or nomination for election was previously so approved) cease for any reason other than death or disability to constitute a majority of
the directors then in office.

Code is the Uniform Commercial Code, as the same may, from time to time, be enacted and
in effect in the State of California; provided, that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such
term contained in Article or Division 9 shall govern; provided further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Banks Lien on any
Collateral is governed by the Uniform Commercial Code in effect in a jurisdiction other than the State of California, the term Code shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely
for purposes on the provisions thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions.



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Collateral is any and all properties, rights and assets of Borrower described on
Exhibit D.

Collateral Account is any Deposit Account, Securities Account, or Commodity Account.

Committed Availability means, as the date of determination, an amount equal to the Revolving Line minus all outstanding Credit
Extensions.

Commodity Account is any commodity account as defined in the Code with such additions to such
term as may hereafter be made.

Communication is defined in Section 10.

Compliance Certificate is that certain certificate in the form attached hereto as Exhibit E.

Contingent Obligation is, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any
indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or
indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all obligations from any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other
agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but Contingent Obligation does not include endorsements in the ordinary course of business. The
amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it determined by the Person in good
faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement.

Control
Agreement is any control agreement entered into among the depository institution at which Borrower maintains a Deposit Account or the securities intermediary or commodity intermediary at which Borrower maintains a Securities Account or a
Commodity account, Borrower, and Bank pursuant to which Bank obtains control (within the meaning of the Code) over such Deposit Account, Securities Account, or Commodity Account.

Credit Extension is any Advance, or any other extension of credit by Bank for Borrowers benefit.

Default means any event which with notice or passage of time or both, would constitute an Event of Default.

Default Rate is defined in Section 2.3(b).

Deferred Revenue is all amounts received or invoiced in advance of performance under contracts and not yet recognized as revenue.

Deposit Account is any deposit account as defined in the Code with such additions to such term as may hereafter be made.

Dollars,dollars and $ each mean lawful money of the United States.

EBITDA shall mean (a) Net Income, plus (b) Interest Expense, plus (c) to the extent deducted in the
calculation of Net Income, depreciation expense and amortization expense, plus (d) income tax expense.

Effective
Date is the date Bank executes this Agreement and as indicated on the signature page hereof.

Equipment is all
equipment as defined in the Code with such additions to such term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the
foregoing.

ERISA is the Employment Retirement Income Security Act of 1974, and its regulations.



-17-



---

Event of Default is defined in Section 8.

Funding Date is any date on which a Credit Extension is made to or on account of Borrower which shall be a Business Day.

GAAP is generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting
Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other Person as may be approved by a significant segment of
the accounting profession, which are applicable to the circumstances as of the date of determination, as applied by Borrower in its audited consolidated financial statements for the year ended December 31, 2004, consistently applied except as
may otherwise be disclosed in the notes to its subsequent consolidated financial statements which inconsistency, in the opinion of the Borrowers auditors, is preferable in order fairly to present such financial statements.

General Intangibles is all general intangibles as defined in the Code in effect on the date hereof with such additions to
such term as may hereafter be made, and includes without limitation, all copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished, any
patents, trademarks, service marks and, to the extent permitted under applicable law, any applications therefor, whether registered or not, any trade secret rights, including any rights to unpatented inventions, payment intangibles, royalties,
contract rights, goodwill, franchise agreements, purchase orders, customer lists, route lists, telephone numbers, domain names, claims, income and other tax refunds, security and other deposits, options to purchase or sell real or personal property,
rights in all litigation presently or hereafter pending (whether in contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of insurance and rights to
payment of any kind.

Guarantor is any present or future guarantor of the Obligations.

Indebtedness is (a) indebtedness for borrowed money or the deferred price of property or services, such as reimbursement and
other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations, and (d) Contingent Obligations.

Insolvency Proceeding is any proceeding by or against any Person under the United States Bankruptcy Code, or any other bankruptcy or
insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief.

Interest Expense means for any fiscal period, interest expense (whether cash or non-cash) determined in accordance with GAAP for the
relevant period ending on such date, including, in any event, interest expense with respect to any Credit Extension and other Indebtedness of Borrower and its Subsidiaries, including, without limitation or duplication, all commissions, discounts, or
related amortization and other fees and charges with respect to letters of credit and bankers acceptance financing and the net costs associated with interest rate swap, cap, and similar arrangements, and the interest portion of any deferred
payment obligation (including leases of all types).

Inventory is all inventory as defined in the Code in
effect on the date hereof with such additions to such term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including
without limitation such inventory as is temporarily out of Borrowers custody or possession or in transit and including any returned goods and any documents of title representing any of the above.

Investment is any beneficial ownership interest in any Person (including stock, partnership interest or other securities), and any
loan, advance or capital contribution to any Person.

IP Agreement is that certain Intellectual Property Security
Agreement executed and delivered by Borrower to Bank dated as of the date hereof.

Key Person is Borrowers Chief
Executive Officer, Frank J. Massino.

Lien is a mortgage, lien, deed of trust, charge, pledge, security interest or
other encumbrance.



-18-



---

Loan Documents are, collectively, this Agreement, the Perfection Certificate, the IP
Agreement, any note, or notes or guaranties executed by Borrower or any Guarantor, and any other present or future agreement between Borrower any Guarantor and/or for the benefit of Bank in connection with this Agreement, all as amended, restated,
or otherwise modified.

Material Adverse Change is (a) a material impairment in the perfection or priority of
Banks Lien in the Collateral or in the value of such Collateral; (b) a material adverse change in the business, operations, or condition (financial or otherwise) of Borrower; or (c) a material impairment of the prospect of repayment
of any portion of the Obligations or (d) Bank determines, based upon information available to it and in its reasonable judgment, that there is a reasonable likelihood that Borrower will fail to comply with one or more of the financial
covenants in Section 6 during the next succeeding financial reporting period.

Net Income means, as calculated on a
consolidated basis for Borrower and its Subsidiaries for any period as at any date of determination, the net profit (or loss), after provision for taxes, of Borrower and its Subsidiaries for such period taken as a single accounting period, in
accordance with GAAP.

Obligations are Borrowers obligation to pay when due any debts, principal, interest, Bank
Expenses and other amounts Borrower owes Bank now or later, whether under this Agreement, the Loan Documents, or otherwise, including, without limitation, all obligations relating to letters of credit, cash management services, and foreign exchange
contracts, if any, and including interest accruing after Insolvency Proceedings begin and debts, liabilities, or obligations of Borrower assigned to Bank, and the performance of Borrowers duties under the Loan Documents.

Operating Documents are, for any Person, such Persons formation documents, as certified by a responsible representative of
Company House (in the case of Borrower) or the Secretary of State of such Persons state of formation of any Person organized under the law of a State of the United States of America on a date that is no earlier than 30 days prior to the
Effective Date, and, (a) if such Person is a corporation, its bylaws in current form (or Memorandum and Articles of Association, in the case of Borrower), (b) if such Person is a limited liability company, its limited liability company
agreement (or similar agreement), and (c) if such Person is a partnership, its partnership agreement (or similar agreement), each of the foregoing with all current amendments or modifications thereto.

Other Equipment is leasehold improvements, intangible property such as computer software and software licenses, equipment specifically
designed or manufactured for Borrower, other intangible property, limited use property and other similar property and soft costs approved by Bank, including taxes, shipping, warranty charges, freight discounts and installation expenses.

Payment/Advance Form is that certain form attached hereto as Exhibit F.

Payment Date is defined in Section 2.1.8(b).

Perfection Certificate is defined in Section 5.1.

Permitted
Indebtedness is:

(a) Borrowers Indebtedness to Bank under this Agreement and the other Loan Documents;

(b) Indebtedness existing on the Effective Date and shown on the Perfection Certificate;

(c) Subordinated Debt;

(d) unsecured
Indebtedness to trade creditors incurred in the ordinary course of business;

(e) Indebtedness incurred as a result of endorsing negotiable
instruments received in the ordinary course of business;

(f) Indebtedness secured by Permitted Liens;



-19-



---

(g) extensions, refinancings, modifications, amendments and restatements of any items of Permitted
Indebtedness (a) through (f) above, provided that the principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be.

Permitted Investments are:

(a) Investments shown on the Perfection Certificate and existing on the Effective Date;

(b) Cash Equivalents;

(c) Investments consisting of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of
Borrower;

(d) Investments consisting of deposit accounts in which Bank has a perfected security interest;

(e) Investments accepted in connection with Transfers permitted by Section 7.1;

(f) Investments consisting of (i) travel advances and employee relocation loans and other employee loans and advances in the ordinary course of
business, and (ii) loans to employees, officers or directors relating to the purchase of equity securities of Borrower or its Subsidiaries pursuant to employee stock purchase plans or agreements approved by Borrowers Board of Directors;

(g) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in
settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business;

(h)
Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are not Affiliates, in the ordinary course of business; provided that this paragraph shall not apply to Investments of
Borrower in any Subsidiary;

Permitted Liens are:

(a) Liens existing on the Effective Date and shown on the Perfection Certificate or arising under this Agreement and the other Loan Documents;

(b) Liens for taxes, fees, assessments or other government charges or levies, either not delinquent or being contested in good faith and for which
Borrower maintains adequate reserves on its Books, if they have no priority over any of Banks Liens;

(c) purchase money Liens
(i) on Equipment acquired or held by Borrower incurred for financing the acquisition of the Equipment securing no more than $50,000 in the aggregate amount outstanding, or (ii) existing on Equipment when acquired, if the Lien is
confined to the property and improvements and the proceeds of the Equipment;

(d) statutory Liens securing claims or demands of
materialmen, mechanics, carriers, warehousemen, landlords and other Persons imposed without action of such parties, provided, they have no priority over any of Banks Lien and the aggregate amount of such Liens does not at any time exceed
$5,000;

(e) Liens to secure payment of workers compensation, employment insurance, old-age pensions, social security and other like
obligations incurred in the ordinary course of business, provided, they have no priority over any of Banks Liens and the aggregate amount of the Indebtedness secured by such Liens does not at any time exceed $10,000;

(f) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (c), but any
extension, renewal or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness may not increase;



-20-



---

(g) leases or subleases of real property granted in the ordinary course of business, and leases,
subleases, non-exclusive licenses or sublicenses of property (other than real property or intellectual property) granted in the ordinary course of Borrowers business, if the leases, subleases, licenses and sublicenses do not prohibit
granting Bank a security interest;

(h) non-exclusive license of intellectual property granted to third parties in the ordinary course of
business;

(i) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under
Section 8.4 or 8.7; and

(j) Liens in favor of other financial institutions arising in connection with Borrowers deposit and/or
securities accounts held at such institutions, provided that Bank has a perfected security interest in the amounts held in such deposit and/or securities accounts.

Person is any individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust, unincorporated organization, association, corporation, institution, public
benefit corporation, firm, joint stock company, estate, entity or government agency.

Prime Rate is Banks most
recently announced prime rate, even if it is not Banks lowest rate.

Registered Organization is any
registered organization as defined in the Code with such additions to such term as may hereafter be made

Responsible
Officer is any of the Chief Executive Officer, President, Chief Financial Officer and Controller of Borrower.

Revolving
Line is an Advance or Advances in an aggregate amount of up to $1,500,000. outstanding at any time.

Revolving Line
Maturity Dateis the second anniversary of the Effective Date.

Securities Account is any securities
account as defined in the Code with such additions to such term as may hereafter be made.

Subordinated Debt is
indebtedness incurred by Borrower subordinated to all of Borrowers now or hereafter indebtedness to Bank (pursuant to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to Bank entered into between
Bank and the other creditor), on terms acceptable to Bank.

Subsidiary means, with respect to any Person, any Person of
which more than 50% of the voting stock or other equity interests is owned or controlled, directly or indirectly, by such Person or one or more Affiliates of such Person.

Transfer is defined in Section 7.1.

Unused Revolving Line Facility
Fee is defined in Section 2.4(b).

Valeant Licenseis the License Agreement dated August 1, 2003 (as
amended by Amendments thereto dated as of December 1, 2003, May 4, 2004, October 31, 2004, and July 15, 2005, and as the same may be hereafter amended) between Valeant Pharmaceuticals International (formerly ICN
Pharmaceuticals, Inc.), a Delaware corporation and Borrower relating to the license of certain patents and other intellectual property of the Borrower.

[Signature page follows.]



-21-



---

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
Effective Date.

BORROWER:

SENETEK PLC



|                                 |  |  |  |           
|-------------------------------- |  |  |  | ----------
|                                
|Signed by                        |  |  |  | (Director)
|For and on behalf of Senetek Plc
|                                
|BANK:                           
|                                
|SILICON VALLEY BANK             
|                                 | 
|By                               |  | 
|Name:                            |  | 
|Title:                           |  | 

|                |  |  |  | 
|--------------- |  |  |  | 
|Effective Date: |  |  |  | 

[Signature page to Loan and Security Agreement]



---

EXHIBIT A

Valeant Licensee Agreement



---

EXHIBIT B

Perfection Certificate



1



---

EXHIBIT C

BORROWING BASE CERTIFICATE



Borrower:

Lender: Silicon Valley Bank

Commitment Amount: $1,500,000



|                                                                                                  |  |   |          
|------------------------------------------------------------------------------------------------- |  | - | ---------
|1. Total minimum payments under the Valeant License coming due in the next four calendar quarters |  | $ |          
|2. 80% of #1                                                                                      |  | $ |          
|3. Revolving Line                                                                                 |  | $ | 1,500,000
|4. Total Permitted Advances (lesser of #2 or #3)                                                  |  | $ |          
|5. Advances Outstanding                                                                           |  | $ |          
|6. Availability Amount (#4 minus #5)                                                              |  | $ |          

The undersigned represents and warrants that this is true, complete and correct, and that the information in
this Borrowing Base Certificate complies with the representations and warranties in the Loan and Security Agreement between the undersigned and Silicon Valley Bank.



|          |  |                   |  |               |  |                                             |  |                  
|--------- |  | ----------------- |  | ------------- |  | ------------------------------------------- |  | -----------------
|COMMENTS: |  |                   |  | BANK USE ONLY
|          |  |                   |  |              
|          |  |                   |  |               |  | Received by:                                |  |                  
|By:       |  |                   |  |               |  |                                             |  | AUTHORIZED SIGNER
|          |  | Authorized Signer |  |               |  | Date:                                       |  |                  
|Date:     |  |                   |  |               |  | Verified:                                   |  |                  
|          |  |                   |  |               |  |                                             |  | AUTHORIZED SIGNER
|          |  |                   |  |               |  | Date:                                       |  |                  
|          |  |                   |  |               |  | Compliance Status:                Yes    No



1



---

EXHIBIT D

The Collateral consists of all of Borrowers right, title and interest in and to the following personal property:

all goods, Accounts (including health-care receivables), Equipment, Inventory, contract rights or rights to payment of money, leases, license agreements,
franchise agreements, General Intangibles, commercial tort claims, documents, instruments (including any promissory notes), chattel paper (whether tangible or electronic), cash, deposit accounts, fixtures, letters of credit rights (whether or not
the letter of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and financial assets, whether now owned or hereafter acquired, wherever located; and

all Borrowers Books relating to the foregoing, and any and all claims, rights and interests in any of the above and all substitutions for,
additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or all of the foregoing;

PROVIDED THAT Collateral shall not include patents, copyrights, trademarks and licenses which are not related to (i) the Valeant License, or the (ii) patents, copyrights, licenses and other
intellectual property which are now or in the future the subject of, or related to the Valeant License, or any right of first offer or other rights under the Valeant License.



1



---

EXHIBIT E

COMPLIANCE CERTIFICATE



|                                  |  |  |  |       |  | 
|--------------------------------- |  |  |  | ----- |  | 
|TO:           SILICON VALLEY BANK |  |  |  | Date: |  | 
|FROM:    SENETEK PLC              |  |  |  |       |  | 

The undersigned authorized officer of SENETEK PLC (Borrower) certifies that under the
terms and conditions of the Loan and Security Agreement between Borrower and Bank (the Agreement), (1) Borrower is in complete compliance for the period ending
 with all required covenants except as noted below, (2) there are no Events of Default,
(3) all representations and warranties in the Agreement are true and correct in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material
respects as of such date, (4) Borrower, and each of its Subsidiaries, has timely filed all required tax returns and reports, and Borrower has timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions owed
by Borrower except as otherwise permitted pursuant to the terms of Section 5.9 of the Agreement, and (5) no Liens have been levied or claims made against Borrower or any of its Subsidiaries relating to unpaid employee payroll or benefits
of which Borrower has not previously provided written notification to Bank. Attached are the required documents supporting the certification. The undersigned certifies that these are prepared in accordance with generally GAAP consistently applied
from one period to the next except as explained in an accompanying letter or footnotes. The undersigned acknowledges that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with any of the terms of
the Agreement, and that compliance is determined not just at the date this certificate is delivered. Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Agreement.

Please indicate compliance status by circling Yes/No under Complies column.



|                                                         |  |                          |  |           
|-------------------------------------------------------- |  | ------------------------ |  | ----------
|Reporting Covenant                                       |  | Required                 |  | Complies  
|Monthly financial statements with Compliance Certificate |  | [Monthly] within 30 days |  | Yes     No
|Annual financial statement (CPA Audited) + CC            |  | FYE within 120 days      |  | Yes     No
|Borrowing Base Certificate A/R & A/P Agings              |  | Monthly within 30 days   |  | Yes     No

The following Intellectual Property was registered after the Effective Date (if no registrations, state
None)





|                                                                                                      |  |          |         |        |                           |          |          
|----------------------------------------------------------------------------------------------------- |  | -------- | ------- | ------ | ------------------------- | -------- | ---------
|Financial Covenant                                                                                    |  | Required |         | Actual |                           | Complies
|Maintain EBITDA of at least $1.00 for each rolling three-month period ending at the end of each month |  | $        | 1.00    |        |                           |          | Yes    No
|                                                                                                      |  |          |        
|Maintain cash in Deposit Accounts at Bank of not less than $300,000                                   |  | $        | 300,000 |        | Lowestbalance:on any day: |          | Yes    No
|                                                                                                      |  |          |         |        | $                         |          |          

The following financial covenant analysis and information set forth in Schedule 1 attached hereto
are true and accurate as of the date of this Certificate.

The following are the exceptions with respect to the certification above: (If no
exceptions exist, state No exceptions to note.)



1



---

______________________________________________________________________________________________________________________________________________

______________________________________________________________________________________________________________________________________________

______________________________________________________________________________________________________________________________________________



|            |  |  |  |               |  |                                     |  |                  
|----------- |  |  |  | ------------- |  | ----------------------------------- |  | -----------------
|SENETEK PLC |  |  |  | BANK USE ONLY
|            |  |  |  |              
|            |  |  |  |               |  | Received by:                        |  |                  
|By:         |  |  |  |               |  |                                     |  | AUTHORIZED SIGNER
|            |  |  |  |              
|Name:       |  |  |  |               |  | Date:                               |  |                  
|            |  |  |  |              
|Title:      |  |  |  |               |  | Verified:                           |  |                  
|            |  |  |  |               |  |                                     |  | AUTHORIZED SIGNER
|            |  |  |  |               |  | Date:                               |  |                  
|            |  |  |  |               |  | Compliance Status:        Yes    No



2



---

Schedule 1 to Compliance Certificate

Financial Covenants of Borrower



|       |  |                         
|------ |  | ------------------------
|Dated: |  | ________________________
|       | 
|       |  | EBITDA (Section 6.7(a)) 

Required:            See chart below



|                                                                    |  |        |     
|------------------------------------------------------------------- |  | ------ | ----
|Period                                                              |  | EBITDA
|For each rolling three-month period ending at the end of each month |  | $      | 1.00

Actual:



|   |  |                                                                     |  |  
|-- |  | ------------------------------------------------------------------- |  | -
|A. |  | Net Income                                                          |  | $
|   |  |                                                                    
|B. |  | To the extent included in the determination of Net Income           |  |  
|   |  |                                                                    
|   |  | 1.      The provision for income taxes                              |  | $
|   |  |                                                                    
|   |  | 2.      Depreciation expense                                        |  | $
|   |  |                                                                    
|   |  | 3.      Amortization expense                                        |  | $
|   |  |                                                                    
|   |  | 4.      Net Interest Expense                                        |  | $
|   |  |                                                                    
|   |  | 5.      All other charges which are both non-cash and non-recurring |  | $
|   |  |                                                                    
|   |  | 6.      All non-cash income                                         |  | $
|   |  |                                                                    
|   |  | 7.      The sum of lines 1 through 5 minus line 6                   |  | $
|   |  |                                                                    
|C. |  | EBITDA (line A plus line B.7)                                       |  |  

Is line C equal to or greater than $1.00?



|                      |  |                   
|--------------------- |  | ------------------
|No, not in compliance |  | Yes, in compliance



3



---

EXHIBIT F

Loan Payment/Advance Request Form

DEADLINE FOR
SAME DAY PROCESSING IS NOON P.S.T.*



|        |  |      
|------- |  | -----
|Fax To: |  | Date:

LOAN PAYMENT:

[Insert Borrower name]



|                      |  |                     |  |  |  |                   |  |                 
|--------------------- |  | ------------------- |  |  |  | ----------------- |  | ----------------
|From Account #        |  |                     |  |  |  | To Account #      |  |                 
|                      |  | (Deposit Account #) |  |  |  |                   |  | (Loan Account #)
|                      |  |                     |  | 
|Principal $           |  |                     |  |  |  | and/or Interest $ |  |                 
|                      |  |                     |  | 
|Authorized Signature: |  |                     |  |  |  | Phone Number:     |  |                 
|Print Name/Title:     |  |                     |  |  |  |                   |  |                 

LOAN ADVANCE:

Complete Outgoing Wire Request section below if all or a portion of the funds from this loan advance are for an outgoing wire.



|                    |  |                  |  |  |  |              |  |                    
|------------------- |  | ---------------- |  |  |  | ------------ |  | -------------------
|                    |  |                  |  | 
|From Account #      |  |                  |  |  |  | To Account # |  |                    
|                    |  | (Loan Account #) |  |  |  |              |  | (Deposit Account #)
|                    |  |                  |  | 
|Amount of Advance $ |  |                  |  |  |  |              |  |                    

All Borrowers representations and warranties in the Loan and Security Agreement are true, correct and
complete in all material respects on the date of the request for an advance; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in
the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date:



|                      |  |  |  |  |  |               |  | 
|--------------------- |  |  |  |  |  | ------------- |  | 
|Authorized Signature: |  |  |  |  |  | Phone Number: |  | 
|Print Name/Title:     |  |  |  |  |  |               |  | 

OUTGOING WIRE REQUEST:

Complete only if all or a portion of funds from the loan advance above is to be wired.

Deadline for same day processing is noon, P.S.T.



|                                                                                                                             |  |  |  |                                                  |  |                               |  | 
|---------------------------------------------------------------------------------------------------------------------------- |  |  |  | ------------------------------------------------ |  | ----------------------------- |  | 
|Beneficiary Name:                                                                                                            |  |  |  |                                                  |  | Amount of Wire: $             |  | 
|Beneficiary Bank:                                                                                                            |  |  |  |                                                  |  | Account Number:               |  | 
|City and State:                                                                                                              |  |  |  |                                                  |  |                               |  | 
|                                                                                                                             |  | 
|Beneficiary Bank Transit (ABA) #:                                                                                            |  |  |  | Beneficiary Bank Code (Swift, Sort, Chip, etc.):
|                                                                                                                             |  |  |  |                                                  |  | (For International Wire Only)
|                                                                                                                             |  |  |  |                                                 
|Intermediary Bank:                                                                                                           |  |  |  |                                                  |  | Transit (ABA) #:              |  | 
|For Further Credit to:     _________________________________________________________________________________________________
|                                                                                                                            
|Special Instruction:     ____________________________________________________________________________________________       



|* | Unless otherwise provided for an Advance bearing interest at LIBOR.
|- | -------------------------------------------------------------------



1



---

By signing below, I (we) acknowledge and agree that my (our) funds transfer request shall be processed in accordance
with and subject to the terms and conditions set forth in the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed by me (us).



|                      |  |  |  |  |  |                             |  |  |  |  |  | 
|--------------------- |  |  |  |  |  | --------------------------- |  |  |  |  |  | 
|Authorized Signature: |  |  |  |  |  | 2ndSignature (if required): |  | 
|Print Name/Title:     |  |  |  |  |  | Print Name/Title:           |  | 
|Telephone #:          |  |  |  |  |  | Telephone #:                |  | 



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