Exhibit 10.101

NEITHER THIS WARRANT NOR ANY OF THE SECURITIES ISSUABLE HEREUNDER NOR ANY AMERICAN DEPOSITARY SHARES REPRESENTING THE SECURITIES ISSUABLE HEREUNDER HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE SECURITIES
ACT), AND NONE OF THEM MAY BE OFFERED, SOLD, TRANSFERRED, ASSIGNED NOR HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO SUCH SECURITIES UNDER THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAW OR AN OPINION
OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED.

WARRANT

to Purchase 2,700,000 Ordinary Shares of

SENETEK PLC

Issued:   March 30, 2006

Expires: March 4, 2011

Series E

NO. 1

This Warrant
certifies that Wallington Investment Holdings, Ltd. or its registered and permitted successors or assigns (Wallington or Holder), is entitled to, subject to the terms set forth below, purchase from SENETEK PLC, a corporation
organized under the laws of England (the Company), from time and time up to Two Million Seven Hundred Thousand (2,700,000) duly authorized, validly issued, fully paid and nonassessable Ordinary Shares (as such number may be adjusted
pursuant to Section 4(a) and Section 5 herein) which may be exchanged for American Depositary Shares (ADSSs) represented by American Depositary Receipts (ADRSs) (the Ordinary Shares of the Company, including any
shares into which they may be changed, reclassified, or converted, are herein referred to as the Ordinary Shares). This Warrant is one of the Series E Warrants (the Warrants) issued pursuant to that certain Agreement dated
March 30, 2006, by and between the Company, Silver Creek Investments, Ltd., Bomoseen Investments, Ltd., Elstree Holdings, Ltd., Dandelion Investments, Ltd., Pearl Waves Ltd., Alba Limited and Wallington (the Agreement). The Ordinary
Shares issuable upon exercise of the Warrants (and any other or additional shares, securities or property that may hereafter be issuable upon exercise of the Warrants) are sometimes referred to herein as the Warrant Shares, and the
maximum number of shares so issuable under this Warrant is sometimes referred to as the Aggregate Number (as such number may be increased or decreased as more fully set forth herein).

This Warrant is subject to the following provisions, terms and conditions:

1. Exercise of Warrant.

To exercise this Warrant in whole or in part, the Holder shall deliver to
the Company at its principal office located at 831 Latour Court, Napa, California 94558, (A) a written notice, in



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substantially the form of the Exercise Notice attached hereto as Exhibit 1, of the Holders election to exercise
this Warrant, which notice shall specify the number of Warrant Shares to be purchased, (B) cash, money order, certified check or wire transfer of immediately available funds payable to the Company, in an amount equal to the Exercise Price (as
defined below) multiplied by the number of Warrant Shares being purchased, and (C) this Warrant. The Company shall as promptly as practicable, and in any event within ten (10) Business Days thereafter, execute and deliver or cause to be
executed and delivered, in accordance with such notice, a certificate or certificates representing the aggregate number of Warrant Shares specified in such notice. The stock certificate or certificates so delivered shall be in such denominations as
may be specified in such notice and shall be issued in the name of the Holder or such other name as shall be designated in such notice. Such certificate or certificates shall be deemed to have been issued and the Holder or any other person so
designated to be named therein shall be deemed for all purposes to have become a Holder of record of such shares immediately prior to the close of business on the date such notice is received by the Company as aforesaid. If this Warrant shall have
been exercised only in part, the Company shall, at the time of delivery of said stock certificate or certificates, deliver to the Holder a new Warrant evidencing the rights of the Holder to purchase the remaining Ordinary Shares called for by this
Warrant, which new Warrant shall in all other respects be identical to this Warrant, or, at the request of the Holder, appropriate notation may be made on this Warrant and the same returned to the Holder. The Company shall pay all expenses, taxes
(except United Kingdom stamp tax duties) and other charges payable in connection with the preparation, issue and delivery of such certificates and new Warrants, except that in case such stock certificates or new Warrants shall be registered in a
name or names other than the name of the Holder, funds sufficient to pay all stock transfer taxes that are payable upon the issuance of such stock certificates or new Warrants shall be paid by the Holder at the time of delivering the notice of
exercise mentioned above.

All Ordinary Shares issued upon the exercise of this Warrant shall be validly issued, fully paid and
nonassessable and free from all preemptive rights of any stockholder, and from all taxes, liens and charges with respect to the issue thereof (other than United Kingdom stamp duty taxes and any other transfer taxes) and, if any Ordinary Shares are
then listed on a national securities exchange (as defined in the Securities Exchange Act of 1934, as amended) or quoted on an automated quotation system, shall be listed or quoted thereon, as the case may be, to the extent permissible under the
rules of such exchange and not prohibited by law, it being understood that such listing does not bear upon the transferability of such shares under the Act and the other provisions of this Agreement.

The Company shall not be required upon any exercise of this Warrant to issue a certificate representing any fraction of an Ordinary Share, but, in lieu
thereof, shall pay to the Holder cash in an amount equal to a corresponding fraction (calculated to the nearest 1/100 of a share) of the Fair Market Value (as defined below) of one Ordinary Share on the Business Day immediately prior to the date of
receipt by the Company of notice of exercise of this Warrant.

The Company shall pay all depositary fees payable to the depositary and all
stamp duty reserve taxes due to Inland Revenue in respect of the issuance of American Depositary Shares or American Depositary Receipts in respect of Ordinary Shares issued upon exercise of the Warrant.



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2. Terms and Conditions of Warrants.

Exercise. Warrants to purchase Two Million Seven Hundred Thousand (2,700,000) (as adjusted in accordance with the principles of
Section 4(a) or Section 5 hereof) Ordinary Shares shall be exercisable at the Exercise Price (as defined in Section 2(b) below) at any time, and from time to time, on or after the date hereof (the Exercise Date), and shall
expire at 11:50 p.m., New York City time, on March 4, 2011 (the Expiration Date).

Purchase Price. Subject to the
provisions of Sections 5 and 6 hereof, the purchase price per Ordinary Share shall be $0.25 (the Exercise Price).

c.
Restrictionson Transfer and Registration Rights.

Each certificate for any Warrant Shares issued upon the exercise
of this Warrant, and each certificate issued upon the transfer of any such Warrant Shares and each American Depositary Receipt representing American Depositary Shares (except as otherwise permitted by this Section 2(c)) shall be stamped or
otherwise imprinted with a legend in substantially the following form:

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ACT), AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO SUCH SECURITIES UNDER THE ACT AND
REGISTRATION OR QUALIFICATION UNDER APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION AND QUALIFICATION IS NOT REQUIRED.

The restrictions imposed by this Section 2(c) upon the transferability of Warrants and Warrant Shares and related American Depositary
Shares shall cease and terminate as to any particular Warrants, Warrant Shares or related American Depositary Shares, (a) when such securities shall have been effectively registered under the Securities Act and disposed of in accordance with
the registration statement covering such securities, or (b) when in the reasonable opinion of counsel for the Company such restrictions are no longer required in order to comply with the Securities Act of 1933, as amended (the Securities
Act). Whenever such restrictions shall terminate as to any Warrants, Warrant Shares or related American Depositary Shares, the Holder thereof shall be entitled to receive from the Company, without expense, new certificates of like tenor not
bearing the restrictive legend set forth in Section 2(c)(i).

d. Investment Representation. The Holder, by acceptance hereof,
represents as of the date hereof, as follows:

i. The Warrant Shares issuable upon exercise of the Warrants (collectively,
the Acquired Securities) will be acquired for investment for the Holders own account, not as a nominee or agent, and not with a view to the resale or distribution of any part of



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the Acquired Securities in contravention of applicable law, and that the Holder has no present intention
of selling, granting any participation in, or otherwise distributing the same. The Holder does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations to such person or to any third
person in or with respect to any of the Acquired Securities.

ii. The Holder is and upon the acquisition of Acquired
Securities upon exercise of the Warrants will be an accredited investor within the meaning of Rule 501 of Regulation D of the rules and regulations of the Securities and Exchange Commission under the Securities Act. The Holder has not
been organized for the purposes of acquiring the Acquired Securities.

iii. The Holder understands that the Acquired
Securities it may acquire as contemplated by this Warrant are restricted securities within the meaning of Rule 144 under the Securities Act (Rule 144) inasmuch as they will be acquired from the Company in a transaction not
involving a public offering and that under the federal securities laws and, applicable regulations such Acquired Securities may be resold without registration under the Securities Act only in certain limited circumstances. In this connection, the
Holder represents that it is familiar with Rule 144 and understands the resale limitations imposed thereby and by the Securities Act. The Holder acknowledges that its investment in the Acquired Securities may be an illiquid investment requiring the
Holder to bear the economic risk of the investment for an indefinite period; and

iv. Without in any way limiting the
representations set forth in this Section 2(d), the Holder agrees not to make any disposition of all or any portion of the Acquired Securities unless and until the transferee has agreed in writing for the benefit of the Company to be bound by
the terms of this Warrant (provided that such Holder is making such disposition in a transaction other than pursuant to Rule 144 or under an effective registration statement under the Securities Act and in accordance with any applicable state
securities laws), and (A) the Holder shall have notified the Company of the proposed disposition, and (B) if requested by the Company, the Holder shall have furnished the Company with an opinion of counsel, in form and substance reasonably
satisfactory to the Company, rendered by a law firm experienced in matters involving the sale of securities under federal and state securities laws, that such disposition will not require registration of the Acquired Securities under the Securities
Act or registration or qualification under any state securities or blue sky law.

In the event certificates for Ordinary Shares
are delivered upon the exercise of this Warrant, the Company may cause a legend or legends to be placed on such certificates to make appropriate reference to such foregoing representations and to restrict transfer in the absence of compliance with
applicable federal or state securities laws.

3. Transfer, Division and Combination.

The Company agrees to maintain at its offices in Napa, California, or such other place at which it may maintain its principal office in the continental
United States of America, books for the registration and transfer of this Warrant and, subject to the provisions of Section 2 hereof,



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this Warrant and all rights hereunder are transferable, in whole or in part, on such books at such office, upon surrender
of this Warrant at such office, together with a written assignment of this Warrant duly executed by the Holder or his agent or attorney and funds sufficient to pay any stock transfer taxes payable upon the making of such transfer. Upon such
surrender and payment, the Company shall execute and deliver a new Warrant or Warrants in the name of the assignee or assignees and in the denominations specified in such instrument of assignment, and this Warrant shall promptly be canceled.
Notwithstanding the foregoing, a Warrant may be exercised by a new Holder for the purchase of Ordinary Shares without having a new Warrant issued if Holder shall otherwise have complied with the foregoing provisions of this Section 3 and the
applicable provisions of Section 2 hereof. All of the provisions of this Section 3 are subject to the provisions of Sections 2 above. This Warrant may be divided or combined with other Warrants upon surrender hereof and of any Warrant or
Warrants with which this Warrant is to be combined, together with a written notice specifying the names and denominations in which the new Warrant or Warrants are to be issued, signed by the holders thereof or their respective duly authorized agents
or attorneys. The Company shall execute and deliver a new Warrant or Warrants exchangeable for the Warrant or Warrants to be divided or combined in accordance with such notice.

4. Successor; Taxes.

Successor
Company. The obligations of the Company under this Warrant shall be binding upon any successor company or organization resulting from the merger, consolidation or other reorganization of the Company, or upon any successor company or organization
succeeding to substantially all of the assets and business of the Company. The Company agrees that it will make appropriate provision for the preservation of Holders rights under this Warrant in any agreement or plan which it may enter into or
adopt to effect any such merger, consolidation, reorganization or transfer of assets.

Taxes on Conversion. The issuance of
certificates for Warrant Shares upon the exercise of this Warrant shall be made without charge to the Holder exercising this Warrant for any issue or stamp tax in respect of the issuance of such certificates, and such certificates shall be issued in
the respective names of, or in such names as may be directed by, the holder; provided, however, that the Company shall not be required to pay any tax that may be payable in respect of any transfer involved in the issuance and delivery of any such
certificate in a name other than that of the Holder, and the Company shall not be required to issue or deliver such certificates unless or until the person or persons requesting the issuance thereof shall have paid to the Company the amount of such
tax or shall have established to the satisfaction of the Company that such tax has been paid.

Withholding Taxes.

Except to the extent otherwise required by law, the Company will not withhold United States or United Kingdom withholding taxes from
payments to be made to holders of Warrants if such holders (a) are corporations organized under the laws of a jurisdiction outside the United States or United Kingdom or are otherwise persons not resident in the United States or United Kingdom
for U.S. federal income tax purposes or United Kingdom tax purposes, and (b) provide the Company, upon the Companys



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reasonable request, with one or more of Internal Revenue Service Form W-8, Form 4224 or other applicable
form, certificate or document prescribed by the Internal Revenue Service of the United States or Inland Revenue of the United Kingdom certifying as to such holders entitlement to an exemption from any such withholding requirements.

Except to the extent otherwise required by law, the Company will not withhold United States or United Kingdom withholding taxes from
payments to be made to holders of Warrants in excess of an applicable treaty rate if such holders (a) are corporations organized under the laws of a jurisdiction outside the United States or United Kingdom or are otherwise persons not resident
in the United States or United Kingdom for U.S. federal income tax purposes or United Kingdom tax purposes, and (b) provide the Company upon the Companys reasonable request, with one or more of certification of their residence address,
Internal Revenue Service Form 1001 or other applicable form, certificates or documents certifying as to such holders entitlement to a reduced rate of withholding under any such withholding requirements.

Except to the extent otherwise required by law, neither Section 4(c)(i) nor Section 4(c)(ii) hereof shall require the Company
to apply an exemption or reduced rate of withholding during any period when it shall have received notice or has knowledge that (a) the residence or other information previously provided on any applicable form, certificate or document is
incorrect and no corrected form, certificate or document as applicable has been provided to the Company, or (b) of any other information which would render such exemption or reduced rate inapplicable.

Notwithstanding the preceding Sections 4(c)(i) and 4(c)(ii), if the Company is required by law to withhold from amounts otherwise payable
to a holder of Warrants, whether by reason of a change in law or applicable treaty, or because the applicable treaty withholding rate is greater than zero or by reason of the failure of a holder of Warrants to provide a valid certification or form,
the Company shall withhold the amounts required to be withheld. Amounts so withheld with respect to a holder in accordance with this Section 4 shall be treated as distributed to such holder for all purposes of this Warrant.

5. Adjustments to Aggregate Number.

The Aggregate Number shall be subject to adjustment from time to time as follows and thereafter as adjusted shall be deemed to be the Aggregate Number hereunder.

Reorganization, Reclassification, Consolidation, Merger or Sale. If any capital reorganization or reclassification of the Company, or any consolidation or merger of the Company with another person, or the sale,
transfer or lease of all or substantially all of its assets to another person shall be effected in such a way that holders of Ordinary Shares shall be entitled to receive stock, securities or assets with respect to or in exchange for their shares,
then provision shall be made, in accordance with this Section 5, whereby the Holder hereof shall thereafter have the right to purchase and receive, upon the basis and upon the terms and conditions specified in this Warrant and in addition to or
in exchange for, as applicable, the Warrant Shares subject to this Warrant immediately theretofore purchasable and receivable upon the exercise of the rights



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represented hereby, such securities or assets as would have been issued or payable with respect to or in exchange for the
Aggregate Number immediately theretofore purchasable and receivable upon the exercise of the rights represented hereby if exercise of the Warrant has occurred immediately prior to such reorganization, reclassification, consolidation, merger or sale.
The Company will not effect any such consolidation, merger, sale, transfer or lease unless prior to the consummation thereof the successor entity (if other than the Company) resulting from such consolidation or merger or the entity purchasing or
leasing such assets shall assume by written instrument (1) the obligation to deliver to such Holder such securities or assets as, in accordance with the foregoing provisions, such Holder may be entitled to purchase, and (2) all other
obligations of the Company under this Warrant. The provisions of this Section 5(a) shall similarly apply to successive consolidations, mergers, exchanges, sales, transfers or leases.

Distributions. If at any time or from time to time the Company shall take a record of the holders of its Ordinary Shares for the purpose of
entitling them to receive or pays any dividend or other distribution to holders of Ordinary Shares (collectively, a Distribution) of:

cash,

any evidences of its indebtedness (other than securities convertible into Ordinary
Shares (Convertible Securities)), any shares of its capital stock (other than additional Ordinary Shares or Convertible Securities) or any other securities or property of any nature whatsoever (other than cash) , or

any options or warrants or other rights to subscribe for or purchase any of the following: any evidences of its indebtedness (other than
Convertible Securities), any shares of its capital stock (other than additional Ordinary Shares or Convertible Securities) or any other securities or property of any nature whatsoever,

then the holder of this Warrant shall be entitled to receive upon the exercise hereof at any time on or after the taking of such record the number of Ordinary Shares to be received upon exercise of such Warrant
determined as stated herein and, in addition and without further payment, the cash, stock, securities, other property, options, warrants and/or other rights to which such holder or holders would have been entitled by way of the Distribution and
subsequent dividends and distributions if such Holder (x) had exercised such Warrants immediately prior to such Distribution, and (y) had retained the Distribution in respect of the Ordinary Shares and all subsequent dividends and
distributions of any nature whatsoever in respect of any stock or securities paid as dividends and distributions and originating directly or indirectly from such Ordinary Shares. A reclassification of the Ordinary Shares into any other class of
stock shall be deemed a distribution by the Company to the holders of its Ordinary Shares or such shares of such other class of stock within the meaning of paragraph (c) of this Section 5 and, if the outstanding Ordinary Shares shall be
changed into a larger or smaller number of Ordinary Shares as a part of such reclassification, such event shall be deemed a subdivision or combination, as the case may be, of the outstanding Ordinary Shares within the meaning of paragraph
(c) of this Section 5. If the securities to be distributed by the Company involve rights, warrants, options or any other form of Convertible Securities and the right to exercise or convert such securities would expire in accordance with
its terms prior to the exercise of this Warrant, then the terms of such securities shall provide that such exercise or convertibility right shall remain in effect until 30 days after the date the Holder of this Warrant receives such securities
pursuant to the exercise hereof.



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In addition to those adjustments set forth in Sections 5(a) and 5(b), but without duplication of the
adjustments to be made under such Sections 5(a) and 5(b) and Section 6, if the Company:

takes a record of the holders
of its Ordinary Shares for the purpose of entitling them to receive or pays a dividend payable in, or other distribution of, Ordinary Shares;

subdivides its outstanding shares of Ordinary Shares into a greater number of Ordinary Shares;

combines its outstanding Ordinary Shares into a lesser number of shares of Ordinary Shares; and/or

makes a
distribution on its Ordinary Shares in shares of its capital stock other than Ordinary Shares,

then (A) the Aggregate Number in effect immediately
prior thereto shall be adjusted so that the holder or holders of this Warrant shall thereafter be entitled to receive, upon exercise hereof, the number of Ordinary Shares or other securities of the Company (such other securities thereafter enjoying
the rights of Warrant Shares under this Warrant) that such Holder would have owned or have been entitled to receive after the occurrence of such event had such Warrants been exercised immediately prior to the occurrence of such event or the record
date with respect thereto, and (B) the Exercise Price shall (until another such event) be adjusted to equal (calculated to the nearest full cent) the quotient derived by dividing (x) the Aggregate Number in effect immediately prior to such
adjustment multiplied by the Exercise Price in effect immediately prior to such adjustment, divided by (y) the Aggregate Number in effect after adjustment pursuant to this Section 5(c).

6. Adjustment to Exercise Price.

If
the Company shall issue or sell any Ordinary Shares at a price which is less than the Exercise Price, then the Exercise Price in effect immediately prior thereto shall be adjusted immediately so that the Exercise Price thereafter shall equal the
price per Ordinary Share at which such Ordinary Shares described in this Section 6(a) were issued. The provisions of this paragraph (a) shall not apply to any issuance of additional Ordinary Shares for which an adjustment is provided under
Sections 5(a), (b) or (c).

If the Company shall take a record of the holders of its Ordinary Shares for the purpose of
entitling them to receive a distribution of, or shall in any manner issue or sell, any warrants or other rights to subscribe for or purchase (x) any shares of Ordinary Shares or (y) any Convertible Securities, whether or not the rights to
subscribe, purchase, exchange or convert thereunder are immediately exercisable, at a purchase price per Ordinary Share which is less than the Exercise Price, then the Exercise Price in effect immediately prior thereto shall be adjusted immediately
so that the Exercise Price thereafter shall equal the consideration for which such Ordinary Shares



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or Ordinary Shares subject to Convertible Securities described in this Section 6(b) were issued. For purposes of
this Section 6(b), the consideration for any additional Ordinary Shares issuable pursuant to any warrants or other rights to subscribe for or purchase the same or for any additional Ordinary Shares issuable pursuant to Convertible Securities
subject to any warrants or other rights shall be the consideration received or receivable by the Company for issuing such warrants or other rights, plus the additional consideration payable to the Company upon the exercise of such warrants or other
rights and upon the exercise of the Convertible Securities, as the case may be.

If the Company shall take a record of the holders of its
Ordinary Shares for the purpose of entitling them to receive a distribution of or shall in any manner issue or sell .Convertible Securities, whether or not the rights to exchange or convert thereunder are immediately exercisable, at a purchase price
per Ordinary Share which is less than the Exercise Price, then the Exercise Price in effect immediately prior thereto shall be adjusted immediately so that the Exercise Price thereafter shall equal the purchase price per Ordinary Share issuable
pursuant to the terms of any Convertible Securities. For purposes of this Section 6(c), the purchase price per Ordinary Share issuable pursuant to the terms of any Convertible Security shall be the cash consideration received or receivable by
the Company for issuing the Convertible Security, plus the additional consideration, if any, payable to the Company upon the purchase of the Ordinary Share pursuant to the Convertible Security.

7. General Provisions Regarding Adjustments to Aggregate Number or Exercise Price.

The following provisions shall be applicable to the making of adjustments of (i) the Aggregate Number as provided in Section 5 or (ii) the
Exercise Price as provided in Section 6:

The sale or other disposition of any issued Ordinary Shares owned or held by
or for the account of the Company shall be deemed an issuance thereof for the purposes of Sections 5 and 6.

The adjustments
required by Sections 5 and 6 shall be made whenever and as often as any specified event requiring an adjustment shall occur, except as expressly provided herein. For the purpose of any adjustment, any specified event shall be deemed to have occurred
at the close of business on the date of its occurrence.

In computing adjustments under Sections 5 and 6, fractional
interests in Ordinary Shares shall be taken into account to the nearest one-thousandth (.001) of a share and shall be aggregated until they equal one whole share.

If the Company shall take a record of the holders of its Ordinary Shares for an action described in Sections 5 or 6 hereof, but abandons
its plan to take such action prior to effecting such action, then no adjustment shall be required by reason of the taking of such record.

Notwithstanding anything herein to the contrary, no adjustment shall be made to the Aggregate Number or Exercise Price as a result of adjustments to the Aggregate Number or Exercise Price as defined in any Warrants
issued to the Holder on the date hereof.



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Upon the expiration or termination of any of the warrants or other rights or options
referred to in Section 6(b) above or the Convertible Securities referred to in Section 6(b) or 6(c) above, the Exercise Price after the expiration or termination of any such warrants, rights, options or Convertible Securities without any
exercise or conversion thereof, the issuance of which caused an adjustment to the Exercise Price, shall be readjusted to such Exercise Price prior to the adjustment made upon the issuance of such warrants, rights, options or Convertible Securities.

In case of the issuance at any time of any additional Ordinary Shares or Convertible Securities in payment or satisfaction
of any dividend upon any class of stock other than Ordinary Shares, the Company shall be deemed to have received for such additional Ordinary Shares or Convertible Securities a consideration equal to the amount of such dividend so paid or satisfied.

No adjustment to the Aggregate Number or Exercise Price shall be made for issuances of (A) options to purchase up to
50,000 Ordinary Shares for any twelve month period after the date of this Warrant pursuant to any stock option plan or resolution of the Company, to the extent such issuances are approved by the Companys directors and made to , or for the
benefit of, employees, Directors or consultants of the Company who were not employees, Directors or consultants of the Company as of the date of this Warrant , and Ordinary Shares issuable or issued upon exercise of such options, (B) Ordinary
Shares issued or issuable upon (x) the exercise of options, warrants or rights to subscribe for or purchase Ordinary Shares, or (y) the conversion or exchange of securities convertible into or exchangeable for Ordinary Shares or options,
warrants or rights to subscribe for or purchase Ordinary Shares, in each case only to the extent outstanding on the date of issuance of this Warrant or (D) Ordinary Shares issued pursuant to a transaction described in Section 5(a) or
(b) hereof.

No adjustment of the Exercise Price shall be made in an amount less than one cent per share, provided that
any adjustments which are not required to be made by reason of this sentence shall be carried forward and shall be taken into account in any subsequent adjustment made.

If any event occurs as to which the provisions of Section 5 or Section 6 are not strictly applicable but the lack of any provision for the exercise of the rights of a holder or holders of Warrants would not
fairly protect the purchase rights of such holder or holders of Warrants in accordance with the essential intent and principles of such provisions, then the Company shall appoint a firm of independent certified public accountants in the United
States (which may be the regular outside auditors of the Company) of recognized national standing in the United States satisfactory to the Holder, which shall give its opinion as to the adjustments, if any, necessary to preserve, without dilution,
on a basis consistent with the essential intent and principles established in the provisions of Section 5 or Section 6, the exercise rights of the holders of Warrants. Upon receipt of such opinion, the Company shall forthwith make the
adjustments described therein.



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Within 45 days after the end of each fiscal quarter during which an event occurred that resulted in an
adjustment pursuant to Section 5 or Section 6, the Company shall cause to be promptly mailed to each holder of Warrants (and upon the exercise of any Warrants to the exercising holder) by first-class mail, postage prepaid, notice of each
adjustment or adjustments to the Aggregate Number or Exercise Price, as the case may be, effected since the date of the last such notice and a certificate of the Companys Chief Financial Officer or, in the case of any such notice delivered
within 45 days after the end of a fiscal year, a firm of independent public accountants in the United States selected by the Company and acceptable to a majority in interest of the holders of the Warrants (who may be the regular outside auditors
employed by the Company), in each case, setting forth the Aggregate Number or Exercise Price, as the case may be, after such adjustment, a brief statement of the facts requiring such adjustment and the computation by which such adjustment was made.
The fees and expenses of such accountants shall be paid by the Company.

8. Covenant to Reserve Shares of Ordinary Shares.

The Company covenants and agrees that it will at all times reserve and set apart and have, free from preemptive rights, a number of shares
of authorized but unissued Ordinary Shares sufficient to enable it at any time to fulfill all its obligations hereunder. The issuance of such shares has been duly and validly authorized, and when issued and sold in accordance with the Warrants, such
shares will be duly and validly issued, fully paid and nonassessable.

9. Notices. In the event that:

1. the Company proposes to pay any dividend payable in stock (of any class or classes) or any obligations or stock convertible into or
exchangeable for shares of Ordinary Shares upon its Ordinary Shares or make any distribution (other than ordinary cash dividends) to the holders of its Ordinary Shares;

2. the Company proposes to grant to the holders of its Ordinary Shares generally any rights or warrants;

3. the Company proposes to effect any capital reorganization or reclassification of capital stock of the Company;

4. the Company proposes to consolidate with, or merge into, any other Company or to transfer its property as an entirety or substantially
as an entirety;

5. the Company proposes to effect the liquidation, dissolution or winding up of the Company, or

6. the Company proposes to enter into any other issuance of securities or other transaction that would implicate any increase or
decrease in the number of Ordinary Shares ultimately issuable pursuant to this Warrant.

then the Company shall cause notice of any such intended action to
be given to the Holder of this Warrant not less than 30 days before the date on which the transfer books of the Company shall close or a record shall be taken for such stock dividend, distribution or granting of rights or Warrants, or the date when
such capital reorganization, reclassification, consolidation, merger, .transfer, liquidation, dissolution or winding up shall be effective, as the case may be.



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Any notice or other document required or permitted to be given or delivered to the Holder of this Warrant
shall be delivered in accordance with Section 15 herein.

10. Limitation of Liability; Not Shareholders.

No provision of this Warrant shall be construed as conferring upon the Holder the right to vote or to consent or to receive dividends or to receive notice
as a shareholder in respect of meetings of shareholders for the election of directors of the Company or any other matter whatsoever as shareholders of the Company. No provision hereof, in the absence of affirmative action by the Holder to purchase
shares of Ordinary Shares, and no mere enumeration herein of the rights or privileges of the Holder, shall give rise to any liability of Holder for the purchase price or as a shareholder of the Company, whether such liability is asserted by the
Company, creditors of the Company or others.

11. Loss, Destruction of Warrant.

Upon receipt of evidence satisfactory to the Company of the loss, theft, mutilation or destruction of this Warrant, and in the case of any such loss,
theft or destruction upon delivery of a bond of indemnity in such form and amount as shall be reasonably satisfactory to the Company (the original Warrant holders indemnity being satisfactory indemnity in the event of loss, theft or
destruction of any Warrant owned by such holder), or in the event of such mutilation upon surrender and cancellation of this Warrant, the Company will make and deliver a new Warrant, of like tenor and representing the right to purchase the same
Aggregate Number of Ordinary Shares, as adjusted in Section 5, as provided for in such lost, stolen, destroyed or mutilated Warrant, in lieu of such lost, stolen, destroyed or mutilated Warrant. Any Warrant issued under the provisions of this
Section 12 in lieu of any Warrant alleged to be lost, destroyed or stolen, or of any mutilated Warrant, shall constitute an original contractual obligation on the part of the Company.

12. Amendments.

Neither this Warrant
nor any term hereof may be changed, waived, discharged or terminated orally or in writing, provided that any term of this Warrant may be amended or the observance of such term may be waived (either generally or in a particular instance and either
retroactively or prospectively) with, but only with, the written consent of the Company and the Holders of the Warrants that are exercisable for a number of Ordinary Shares that represent in the aggregate at least a majority of the total number of
Ordinary Shares for which all of the Warrants are then exercisable (whether or not the Holder of this Warrant consents).

13.
Severability.

If in any jurisdiction, any provision of this Agreement or its application to any party or circumstance is restricted,
prohibited or unenforceable, such provision shall, as to such jurisdiction, be ineffective only to the extent of such restriction, prohibition or unenforceability without invalidating the remaining provisions hereof and without affecting the
validity or enforceability of such provision in any other jurisdiction or its application to other parties or circumstances.



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14. Notice.

Any notice or document required or permitted by this Agreement to be .given to a party hereto shall be in writing and is sufficiently given if delivered personally, or if sent by prepaid certified mail, return receipt
requested, to such party addressed as follows:



|     |  |                    |  |                                      
|---- |  | ------------------ |  | -------------------------------------
|(i)  |  | If to the Company: |  | Senetek Plc                          
|     |  |                   
|     |  |                    |  | 620 Airpark Road                     
|     |  |                    |  | Napa, California 94558               
|     |  |                    |  | Attention: President                 
|     |  |                   
|(ii) |  | If to the Holder:  |  | c/o Nomina Financial Services        
|     |  |                    |  | Augustinergasse 21                   
|     |  |                    |  | P.O. Box 6627                        
|     |  |                    |  | CH-8023 Zurich Switzerland           
|     |  |                   
|     |  | copies to:         |  | Robert J. Sutcliffe                  
|     |  |                    |  | 601 West Fifth Street                
|     |  |                    |  | Suite 1111                           
|     |  |                    |  | Los Angeles, California 90071        
|     |  |                   
|     |  |                    |  | And                                  
|     |  |                    |  | Michael Khoury                       
|     |  |                    |  | 7292 BerryHill Drive                 
|     |  |                    |  | Rancho Palos Verses, California 90275

Notice so mailed shall be deemed to have been given upon receipt if delivered personally or on the fifth business
day next following the date of the returned receipt. Any notice delivered to the party to whom it is addressed shall be deemed to have been given and received on the day it is delivered. Any party may from time to time notify the others in the
manner provided herein of any change of address which thereafter, until changed by like notice, shall be the address of such party for all purposes hereof.

15. Governing Law; Choice Of Forum; Certain Consents; Waiver Of Jury Trial, Counterclaim, Setoff.

THIS WARRANT SHALL BE DEEMED TO HAVE BEEN EXECUTED AND DELIVERED. AT AND SHALL BE DEEMED TO HAVE BEEN MADE IN NEW YORK, NEW YORK. THIS WARRANT, AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER SHALL BE CONSTRUED IN ACCORDANCE WITH
AND BE GOVERNED BY THE SUBSTANTIVE LAWS OF THE STATE OF NEW YORK (WITHOUT



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GIVING EFFECT TO ANY OF SUCH STATES CONFLICT OF LAWS RULES OR PRINCIPLES). ANY LEGAL ACTION OR PROCEEDING WITH
RESPECT HERETO AND THERETO SHALL ONLY BE BROUGHT IN ANY STATE OR FEDERAL COURT IN THE BOROUGH OF MANHATTAN, NEW YORK CITY, NEW YORK, AND, BY EXECUTION, ACCEPTANCE AND DELIVERY OF THIS WARRANT, THE COMPANY HEREBY IRREVOCABLY ACCEPTS FOR ITSELF AND IN
RESPECT OF ITS PROPERTY, GENERALLY AND UNCONDITIONALLY, THE JURISDICTION OF THE AFORESAID COURTS AND IRREVOCABLY WAIVES ANY OBJECTION, DEFENSE OR CLAIM TO SUCH JURISDICTION WHICH MAY BE BASED, DIRECTLY OR INDIRECTLY, ON THE GROUNDS OF FORUM NON
CONVENIENS THAT IT MAY NOW OR HEREAFTER HAVE TO THE BRINGING OF ANY ACTION OR PROCEEDING IN SUCH JURISDICTION IN RESPECT OF THIS WARRANT. IF ANY ACTION IS COMMENCED IN ANY OTHER JURISDICTION, THE PARTIES HERETO HEREBY CONSENT TO THE REMOVAL OF SUCH
ACTION TO THE AFOREMENTIONED COURTS. THE COMPANY FURTHER IRREVOCABLY CONSENTS TO THE SERVICE OF PROCESS OUT OF ANY OF THE AFOREMENTIONED COURTS IN ANY SUCH ACTION OR PROCEEDING BY THE MAILING OF COPIES THEREOF BY REGISTERED OR CERTIFIED MAIL,
POSTAGE PREPAID, TO THE COMPANY AT ITS ADDRESS, SUCH SERVICE TO BECOME EFFECTIVE 30 DAYS AFTER SUCH MAILING. NOTHING HEREIN SHALL AFFECT THE RIGHT OF THE HOLDERS OF ANY OF THE WARRANTS OR WARRANT SHARES TO SERVE PROCESS IN ANY OTHER MANNER PERMITTED
BY LAW OR COMMENCE LEGAL PROCEEDINGS OR OTHERWISE PROCEED AGAINST THE COMPANY IN ANY OTHER JURISDICTION. THE COMPANY WAIVES IN EACH SUCH ACTION AND OTHER LEGAL PROCEEDING THE RIGHT TO TRIAL BY JURY AND THE RIGHT TO ASSERT ANY COUNTERCLAIM OR SETOFF.

[signature page follows; remainder of page left intentionally blank]



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IN WITNESS WHEREOF, the Company has caused this Warrant to be signed in its name by its duly
authorized officer.

Dated: March 30, 2006



SENETEK PLCBy:

/s/ Frank J. MassinoName:

Frank J. MassinoTitle:

Chairman of the Board and Chief Executive Officer




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Exhibit 1

EXERCISE NOTICE

The undersigned Holder hereby elects to exercise purchase rights represented by such
Warrant for, and to purchase thereunder  Ordinary Shares covered by such Warrant and herewith makes payment in full therefore of
$ cash and/or by cancellation of $ of indebtedness of the Company to the Holder hereof and
requests that, subject to the terms and conditions of the Warrant, certificates for such shares (and any securities or property deliverable upon such exercise) be issued in the name of and delivered to
 whose address is
,
and whose social security or employer identification number is .

The undersigned agrees that, in the absence of an effective registration statement with respect to Ordinary Shares issued upon this exercise, the undersigned is acquiring such Ordinary Shares for the Holders own account and not as a
nominee for any other party, for investment and not with a view to distribution thereof and that the certificate or certificates representing such Ordinary Shares may bear a legend substantially as follows:

THESE SHARES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED IN
THE ABSENCE OF- A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO SUCH SECURITIES UNDER THE ACT AND APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED.

In addition, the undersigned agrees that, in the absence of an effective registration statement with respect to Ordinary Shares issued upon this
exercise, stop transfer instructions -will be entered on the Companys stock transfer records with respect to Ordinary Shares issued upon this exercise.



|Dated: | 
|------ | 

Signature
guaranteed:



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FORM OF ASSIGNMENT

FOR VALUE RECEIVED the undersigned registered Holder of the within Warrant hereby sells, assigns, and transfers unto the Assignee(s) named below (including the undersigned with respect to any Warrants constituting a
part of the Warrants evidenced by the within Warrant not being assigned hereby) all of the right of the undersigned under the within Warrant, with respect to the number of Warrants set forth below:



|                  |  |         |  |                                                        |  |                   
|----------------- |  | ------- |  | ------------------------------------------------------ |  | ------------------
|Name of Assignees |  | Address |  | Social security orother identifyingnumber of Assignees |  | Number of Warrants





and does hereby irrevocably constitute and appoint.  the undersigneds attorney to make such transfer on the books of
 maintained for that purpose, with full power of substitution in the premises.



|       |  |                          
|------ |  | -------------------------
|Dated: |  |                          
|       |  | (1)                      
|       |  | (Signature of Owner)     
|       | 
|       |  | (Street Address)         
|       | 
|       |  | (City) (State) (Zip Code)

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|(1) | The signature must correspond with the name as written upon the face of the within Warrant in every particular, without alteration or enlargement or any change whatsoever.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------