UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 

## JUL 20 

## 2011

MEMORANDUM OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### SUBJECT: BEAD Chemical Profile for Registration Review: Dinotefuran (044312)


### FROM: David Brassard, Senior Entomologist

### ~~**~** Biological Analysis Branch



### THRU:

TO: Jihad Alsadek, Ph.D., Economist

# ~**~** Science Information and Analysis Branch

### Michell~**Ranville~** Economist 

# l.f1--W Econottnc AnalYSIS Branch Biological and Economic Analysis Division (7503P} Arnet Jones, Chief Biological Analysis Br Diann Sims, Chief 

# Jtl**~'"-1..~~~';<** Science Information and Analysis Branch Timothy Kieiy, Chief
.

# y 1 ••

# ~ Economic Analysis Branch 

# \J

. ) II\J\. Biological and**Econo~c** 

### Analysis Division (7503 Steven Snyderman, Chemical Review Manager Risk Management and Implementation, Branch 3 Pesticide**Re-~valuation** 

### Division (7508P)


### Product Review Panel date: July 6, 2011 INTRODUCTION The purpose ofthis document is to convey usage information and a broad overview ofthe pest management roles ofpesticides that are beginning to undergo registration review. The**anti~ipated** 

### audience consists ofthe team ofEPA staffcurrently evaluating the registration status ofDinotefuran, and eventually the general public. This document builds upon the data already 

### 1provided in the "Usage and Label Use DataPackages" that are also provided to Registration Reviewteams by BEAD. The document is based on information and data available to BEAD as ofJune 29,2011. Dinotefuran is a broad-spectrum neonicotinoid insecticide in the nitroguanidine sub-class. Dinotefuran acts onthe central nervous system by binding to the postsynaptic nicotinic acetylcholine receptor. Dinotefuran is highly water soluble and is readily translocated inplant tissue giving it good systemic activity. Dinotefuran was first registered in the U.S. in 2004. Dinotefuran has stomach and contact activity and is effective against a wide variety ofinsects including aphids, whiteflies, thrips, leafhoppers, leafminer, sawflies, mole crickets, white grubs,**lacebugs~** billbugs, beetles, mealybugs, stinkbugs, weevils, and cockroaches (U.S. EPA, 2004). 

### USE SITES Agricultural Use Sites Cucutbits, grapes, pineapple, nuttrees, fruiting vegetables, brassicavegetables, and leafy vegetables. Non-Agricultural Use Sites Forest trees, Ornamental plants (flowering and foliage plants, woody shrubs, vines, andtrees), Ornamental lawns andturf, pets andpetpremises, animal premises, domestic dwellings, picnic areas, transportation vehicles, food handling establishments, hospitals, and commercial/ institutional/industrial buildings 

### COMMON FORMULATIONS AND APPLICATION METHODS Dinotefuran is formulated as granules, emulsifiable concentrate, ready-to use solution and as a pressurized liquid. 

### USAGE Agricultural Based onprivate marketpesticide usage data from 2006-2010, the annual total agricultural usage averaged approximately 4,000 pounds active ingredient for-30,000 acres for an overall average ofO.1lbs. a.i. application rate per acre. In comparison, the average aj. application rate in lbs. a.i. per acre is 0.1 for wine grapes, 0.2 for cantaloupes, 0.1 for rice, and 0.2 for bothwatermelons and tomatoes. From 2006-2010, the largest markets interms oftotal pounds a.i. applied are wine grapes (35%), cantaloupes (17%), rice (12%), and watermelons andtomatoes (10% each). The highesttotal areatreated (TAT) are wine grapes (41%), rice (19%), cantaloupes (11%), watermelons (7%), and tomatoes (6%). On average, the states with the most agricultural usage interms ofpounds a.i. applied are California (43%), Arizona (20%), Texas (18%), and Florida (13%). (proprietary Data, 2006- 2010).
2Non-Agricultural Non-agricultural usage data are not available from our current data sources. 

### USE TRENDS Figurel provides usage trends, interms ofpounds**applied ~**  for dinotefuran's largest agricultural markets. Dinotefuran was first registered in 2004 and no usage showed up until 2006. Although there was no use ofdinotefuran on cantaloupes in 2007, use increased from 2008 to 2010. The use on wine grapes increased from 2006 to 2008 and declined thereafter
. There was no use in 2006 and 2007 onrice and tomatoes and the use increased afterwards. Among the other crops, the use on squash increased from 2006 to 2010
. 

### Figure 1. 

### DinotefuranAgricultural Usage Data 20,000 ...--------- ---

• Other Crops PoundsA.f. • Watermelons • Tomatoes
• Rice 

### o • Grapes, Wine 2006 2007 2008 2009 2010 • Cantaloupes Years

Source: Proprietary Data, 2006-2010 "Other crops" with significant usage ofdinotefuran includes potatoes and lettuce (4% each), squash (3%), and cabbage/cucumbers/pumpkins/broccoli (1% each). 

### BIOLOGICAL ASPECTS RELEVANT TO DINOTEFURAN Inthe future, dinotefuran could beimportant for the control ofrice water weevil, Research indicates that dinotefuran is nearly as effective as carbofuran at controlling the rice weevil and that ithas a long treatment windowmaking mistakes in applicationtiming less likely. (Brassard and Smearman, 2005) 

### HISTORY OFBEAD ASSESSMENTS, FORDINOTEFURAN There have been at least 11Section 18 emergency exemptionrequests for'Dinotefuran. BEAD conducted assessments for ofthese requests. Table 1 summarizes those requests and BEAD's recommendations.



### 3Table 1. Section 18 Emergency Exemption Requests for Dinotefuran DP Year State Site Pest BEAD recommendation Barcode (common name) 

### 332830 2006 TX Brassica Whiteflies Non-routine: SEL likely LeafyVeg 

### 354338 2008 TX Rice Rice Stink Bug Routine; insufficient data for econ analysis 

### 362186 2008 TX Rice Rice Stink Bug Non-routine; SEL likely 

## * 374523 2010 TX Rice Rice Stink Bug Non-routine; SEL likely 388990 VA 389143 DE 389435 PA Pomeand brown 391460 

### 2011 NC stone marmorated Non-routine; SEL likely 391458 MD fruits stinkbug 391459 NJ 391461 WV Sources: Year, state, site, and pest name from EPA Section 

### 18 Database; BEAD recommendations from BEAD Official Records 

## *This was a change to an earlier decision 

### (354338)
Two BEAD assessments have also indicated that Dinotefuran is important to the control ofrice stink bug inthatthe insect has developed resistance to pyrethroids. (Cook and Faulkner, 2010; Chiri and Faulkner, 2009) DATA NEEDS RELEVANT TO BEAD'S FUTUREWORK ON DINOTEFURAN Obtaining additional information on the following items would improve future BEAD assessments ofthe importance ofDinotefuran and may be required as part ofthe registration review ofthis pesticide: • Warehouses, commercial/industrial machinery, bathrooms, and garbage areas.

REFERENCES Brassard, D. and**Smearm~,** S. 2005. BEAD's Review ofDocumentation Submitted in Support ofEmergency Exemption for the Use ofCarbofuranonRice to Control the Rice Water Weevil (05LA01; DP#312323). Brassard, D. and Lee, A. 2006. BEAD Review ofTexas Emergency Exemption Requestfor Dinotefuran to Control Whiteflies onBrassica Leafy Vegetables (06TX38; DP#332830) Brassard, D. and Lee, A. 2011. BEAD Review ofa Regional Emergency Exemption Request for the Use ofDinotefuran to Control Brown Marmorated StinkBugs onPome and Stone Fruits in 7 Mid-Atlantic States (llVA02; llDE02, llPA01, llNC01, llMD01, llNJ01, llWV02 (DP # 388990, 389143, 389435, 391460, 391458, 391459, 391461).

4Chiri, A. and Faulkner, 

### J. 2009. Review ofAddendum to Section 18 Request for Dinotefuranto Control Rice Stink Bug on Rice (08TXll; DP#362186). Cook, C. and Smearman, S. 2008. Review ofan Emergency Exemption for Dinotefuran forUse to Manage Rice Stink Bug on Rice inTexas (08TXll; DP#354338). Cook. C. and Faulkner, 

### J. 2010. Review ofSection 18 Request for Dinotefuranto Control Rice Stink Bug on Rice (10TX03; DP# 374523). Leskey, T.C. 2011. The Challenges Posed bythe Invasive BrownMarmorated Stink Bug, Halyomorpha halys**(S~),** to U.S. Agriculture. InsecfBehavior and Chemical Ecology Laboratory, USDA-ARS, Appalachian Fruit Research Station, Kearneysville, WV 25430, 61 pp. Available at www.frederick.umd.edulfiles/Stinkbug-BMSBUSDA-EPA2-16.pdf
. Leskey, T.C. et al. 2010. Appendix 1. BMSB Lethality (Dry Residue, Glass). Unpublished data. USDA-ARS, Insect Behavior and Chemical Ecology Laboratory, Appalachian Fruit Research Station, Kearneysville, WV 25430. Proprietary Data, 2006-2010 U.S. EPA. 2004. Dinotefuran Fact Sheet. http://www.epa.gov/opprdOO1 /factsheets/dunotefuran.pdf



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